PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
11237252-2	2001	We herein report the isolation and full characterization of a Co(I)-TDHC species and X-ray crystal structures and full characterization of related Co(II) and Co(III) corrins as models for vitamin B12 complexes.	Vitamin B 12	188-199	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-153
11227912-10	2001	ACh and SP increased COX 2 mRNA in the three groups.	Acetylcholine	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-26
11275626-2	2001	NSAIDs act by reducing prostaglandin biosynthesis through inhibition of cyclooxygenase (COX) which exists as two isoforms (COX-1 and COX-2).	Prostaglandins	23-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	133-138
11275626-5	2001	Recent studies have demonstrated that COX-2 is constitutively expressed in renal tissues of all species; this isoform may, therefore, be intimately involved in prostaglandin-dependent renal homeostatic processes.	Prostaglandins	160-173	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-43
11275626-7	2001	This assertion is borne out by recent clinical studies showing that the COX-2 inhibitors rofecoxib and celecoxib procedure qualitative changes in urinary prostaglandin excretion, glomerular filtration rate, sodium retention, and their consequences similar to nonselective NSAIDs.	rofecoxib	89-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
11275626-7	2001	This assertion is borne out by recent clinical studies showing that the COX-2 inhibitors rofecoxib and celecoxib procedure qualitative changes in urinary prostaglandin excretion, glomerular filtration rate, sodium retention, and their consequences similar to nonselective NSAIDs.	Celecoxib	103-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
11275626-7	2001	This assertion is borne out by recent clinical studies showing that the COX-2 inhibitors rofecoxib and celecoxib procedure qualitative changes in urinary prostaglandin excretion, glomerular filtration rate, sodium retention, and their consequences similar to nonselective NSAIDs.	Prostaglandins	154-167	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
11275626-7	2001	This assertion is borne out by recent clinical studies showing that the COX-2 inhibitors rofecoxib and celecoxib procedure qualitative changes in urinary prostaglandin excretion, glomerular filtration rate, sodium retention, and their consequences similar to nonselective NSAIDs.	Sodium	207-213	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
11152649-2	2001	Human airway smooth muscle (HASM) cells release granulocyte macrophage-colony stimulating factor (GM-CSF) and express cyclooxygenase (COX)-2 (resulting in the release of prostaglandin [PG] E2) after stimulation with cytokines.	Dinoprostone	170-191	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-140
11152649-5	2001	Indomethacin and other COX-1/COX-2 inhibitors caused concentration-dependent inhibitions of PGE2 concomitantly with increases in GM-CSF formation.	Dinoprostone	92-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34
11304658-4	2001	Both isozymes form prostaglandins that support physiologic functions; however, the formation of proinflammatory prostaglandins is catalyzed by COX-2.	Prostaglandins	19-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	143-148
11304658-4	2001	Both isozymes form prostaglandins that support physiologic functions; however, the formation of proinflammatory prostaglandins is catalyzed by COX-2.	Prostaglandins	112-126	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	143-148
11205498-0	2001	Determination of Co(II) by chemiluminescence after in situ electrochemical pre-separation on a flow-through mercury film electrode.	Mercury	108-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-23
11205498-2	2001	The Co(II) ions were selectively pre-separated on a mercury film electrode (MFE) by on-line reduction, then the accumulated metal was oxidised and selectively stripped back into the flowing solution as Co(II).	Mercury	52-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
11205498-2	2001	The Co(II) ions were selectively pre-separated on a mercury film electrode (MFE) by on-line reduction, then the accumulated metal was oxidised and selectively stripped back into the flowing solution as Co(II).	Metals	124-129	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
11205498-2	2001	The Co(II) ions were selectively pre-separated on a mercury film electrode (MFE) by on-line reduction, then the accumulated metal was oxidised and selectively stripped back into the flowing solution as Co(II).	Metals	124-129	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	202-208
11437671-4	2001	The development of novel "super aspirins" with high selectivity towards the inhibition of COX-2 showed that this hypothesis was well-founded and that high levels of these drugs could be tolerated without these serious adverse effects.	Aspirin	32-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-95
11437671-10	2001	The suggestion has now been made that, in these situations, COX-2 may help resolve the pathology, perhaps by generating alternative series of prostaglandins such as the cyclopentenone prostaglandins.	Prostaglandins	142-156	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-65
11437671-10	2001	The suggestion has now been made that, in these situations, COX-2 may help resolve the pathology, perhaps by generating alternative series of prostaglandins such as the cyclopentenone prostaglandins.	cyclopentenone	169-183	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-65
11437671-10	2001	The suggestion has now been made that, in these situations, COX-2 may help resolve the pathology, perhaps by generating alternative series of prostaglandins such as the cyclopentenone prostaglandins.	Prostaglandins	184-198	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-65
11580300-7	2001	However, by decreasing prostacyclin production, COX-2 inhibitors may lead to increased prothrombotic activity and increase the risk of cardiovascular events.	Epoprostenol	23-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-53
11156583-10	2001	The COX2 inhibitor L-745,337 (1--10 microM) contracted the isolated ductus at term, the response being almost as high as that to indomethacin (dual COX1/COX2 inhibitor) over the same dose-range.	l-745	19-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-8
11159736-10	2001	Overexpression of COX-2 in SW480 cells protected them against induction of apoptosis by sulindac sulfide.	sulindac sulfide	88-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-23
11195058-6	2001	Whereas COX1 expression does not exhibit dynamic regulation, COX2 expression is subject to regulation by several environmental conditions, including salt intake, water intake, medullary tonicity, growth factors, cytokines, and adrenal steroids.	Salts	149-153	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-65
11296542-0	2001	Introduction to "nimesulide: beyond COX-2".	nimesulide	17-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-41
11196178-1	2001	Cyclooxygenase (COX)-2 is an inducible enzyme involved in production of prostaglandins in inflammatory processes.	Prostaglandins	72-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-22
11196178-9	2001	Treatment with NS-398 (50 microM), a specific inhibitor of COX-2, suppressed PGE2 production of all melanoma cell lines by 50-96%.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	15-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-64
11196178-9	2001	Treatment with NS-398 (50 microM), a specific inhibitor of COX-2, suppressed PGE2 production of all melanoma cell lines by 50-96%.	Dinoprostone	77-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-64
11196178-10	2001	The IC50 for inhibition of PGE2 production by NS-398 was determined as 4 microM, indicating that NS-398 acts via inhibition of the COX-2 isoenzyme.	Dinoprostone	27-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-136
11196178-10	2001	The IC50 for inhibition of PGE2 production by NS-398 was determined as 4 microM, indicating that NS-398 acts via inhibition of the COX-2 isoenzyme.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	46-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-136
11196178-10	2001	The IC50 for inhibition of PGE2 production by NS-398 was determined as 4 microM, indicating that NS-398 acts via inhibition of the COX-2 isoenzyme.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	97-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-136
11296546-2	2001	Nimesulide or NS-398 inhibited IL-1 beta-induced PGE2 production at all concentrations tested, and in addition they suppressed IL-1 beta-induced COX-2 mRNA expression and protein synthesis.	nimesulide	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-150
11296546-2	2001	Nimesulide or NS-398 inhibited IL-1 beta-induced PGE2 production at all concentrations tested, and in addition they suppressed IL-1 beta-induced COX-2 mRNA expression and protein synthesis.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	14-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-150
11296546-4	2001	Mechanistic studies revealed that the drug-induced inhibition of COX-2 expression and synthesis was not promoter-based, but may be associated with the blockade of IL-1 beta-dependent calcium flux and increased cellular calcium levels.	Calcium	183-190	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-70
11296546-4	2001	Mechanistic studies revealed that the drug-induced inhibition of COX-2 expression and synthesis was not promoter-based, but may be associated with the blockade of IL-1 beta-dependent calcium flux and increased cellular calcium levels.	Calcium	219-226	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-70
11296547-4	2001	Pre-treatment of the cultures with nimesulide, a preferential cyclooxygenase (COX)-2 inhibitor, or with ibuprofen, a non-selective COX-1/COX-2 inhibitor, protected the chondrocytes against the staurosporine-mediated nuclear damage and cell death in a concentration-dependent manner (10(-12) to 10(-6) M).	nimesulide	35-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-84
11296547-4	2001	Pre-treatment of the cultures with nimesulide, a preferential cyclooxygenase (COX)-2 inhibitor, or with ibuprofen, a non-selective COX-1/COX-2 inhibitor, protected the chondrocytes against the staurosporine-mediated nuclear damage and cell death in a concentration-dependent manner (10(-12) to 10(-6) M).	Ibuprofen	104-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-142
11900314-1	2001	BACKGROUND: The selective COX-2 inhibitor celecoxib has a sulfonamide structure and is contraindicated for patients with known sulfa allergy.	Celecoxib	42-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-31
11900314-1	2001	BACKGROUND: The selective COX-2 inhibitor celecoxib has a sulfonamide structure and is contraindicated for patients with known sulfa allergy.	Sulfonamides	58-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-31
11900314-1	2001	BACKGROUND: The selective COX-2 inhibitor celecoxib has a sulfonamide structure and is contraindicated for patients with known sulfa allergy.	dimethyl trisulfide	127-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-31
11195058-6	2001	Whereas COX1 expression does not exhibit dynamic regulation, COX2 expression is subject to regulation by several environmental conditions, including salt intake, water intake, medullary tonicity, growth factors, cytokines, and adrenal steroids.	Water	162-167	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-65
11590304-0	2001	Rofecoxib: a new selective COX-2 inhibitor.	rofecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-32
11398914-1	2001	Rofecoxib is a selective cyclo-oxygenase (COX)-2 inhibitor which has little or no effect on the COX-1 isoenzyme at doses up to 1000 mg/day.	rofecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-48
11398914-2	2001	Rofecoxib has greater selectivity for COX-2 than celecoxib, meloxicam, diclofenac and indomethacin.	rofecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-43
11478355-1	2001	The discovery of two cyclooxygenase isozymes, constitutive COX-1 and inducible COX-2, has resulted in the rapid development of selective inhibitors of COX-2, such as celecoxib and rofecoxib.	rofecoxib	180-189	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-84
11478355-1	2001	The discovery of two cyclooxygenase isozymes, constitutive COX-1 and inducible COX-2, has resulted in the rapid development of selective inhibitors of COX-2, such as celecoxib and rofecoxib.	rofecoxib	180-189	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-156
11478355-4	2001	Futhermore, selective COX-2 inhibitors may have other consequences as a result of the change in the eicosanoid profile.	Eicosanoids	100-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-27
11076710-1	2001	Prostaglandins (PGs) derived from inducible cyclooxygenase (COX)-2 are important proinflammatory mediators of the host-immune response to infection.	Prostaglandins	0-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-66
11076710-1	2001	Prostaglandins (PGs) derived from inducible cyclooxygenase (COX)-2 are important proinflammatory mediators of the host-immune response to infection.	Prostaglandins	16-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-66
11076710-5	2001	Investigation of COX-2 regulatory cytokines revealed an inverse correlation (P<.001) between plasma levels of bicyclo-PGE2 and interleukin (IL)-10, a cytokine that suppresses COX-2 expression.	bicyclo-PGE2	113-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22
11076710-5	2001	Investigation of COX-2 regulatory cytokines revealed an inverse correlation (P<.001) between plasma levels of bicyclo-PGE2 and interleukin (IL)-10, a cytokine that suppresses COX-2 expression.	bicyclo-PGE2	113-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	178-183
11140899-5	2001	NS-398, a selective COX-2 inhibitor, inhibited proliferation of NA cells, a squamous cell caricinoma cell line that constitutively expresses COX-2 mRNA.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	0-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-25
11140899-5	2001	NS-398, a selective COX-2 inhibitor, inhibited proliferation of NA cells, a squamous cell caricinoma cell line that constitutively expresses COX-2 mRNA.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	0-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	141-146
11140899-7	2001	Similar results were obtained from experiments using COX-2 antisense oligonucleotide.	Oligonucleotides	69-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-58
11140899-8	2001	These results suggest that specific inhibition of COX-2 inhibits proliferation of cancer cells expressing COX-2 mRNA via suppression of PGE2 production.	Dinoprostone	136-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-55
11140899-8	2001	These results suggest that specific inhibition of COX-2 inhibits proliferation of cancer cells expressing COX-2 mRNA via suppression of PGE2 production.	Dinoprostone	136-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-111
11595463-5	2001	This study aimed to determine whether indomethacin (IND) and/or the selective COX-2 inhibitor, NS-398, interfere with egr-1 gene expression in human microvascular endothelial cells (HMVEC) in response to vascular endothelial growth factor (VEGF) stimulation.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	95-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-83
11195395-0	2001	[CoII(4-terpyridone)2]X2: a novel cobalt(II) spin crossover system [4-terpyridone = 2,6-bis(2-pyridyl)-4(1H)-pyridone].	Cobalt(2+)	34-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	1-5
11195395-0	2001	[CoII(4-terpyridone)2]X2: a novel cobalt(II) spin crossover system [4-terpyridone = 2,6-bis(2-pyridyl)-4(1H)-pyridone].	2,6-Bis(2-pyridyl)-4(1H)-pyridone	6-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	1-5
11195395-0	2001	[CoII(4-terpyridone)2]X2: a novel cobalt(II) spin crossover system [4-terpyridone = 2,6-bis(2-pyridyl)-4(1H)-pyridone].	2,6-Bis(2-pyridyl)-4(1H)-pyridone	84-117	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	1-5
11595413-5	2001	Moreover, concerns have been recently expressed that as COX-2 is important in ulcer healing, control of prostacyclin production and renal function that they may have adverse reactions from these effects.	Epoprostenol	104-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-61
18475995-0	2001	Synthesis, Characterization and Antiproliferative Activity of the Co(II), Ni(II), Cu(II), Pd(II) and Pt(II) Complexes of 2-(4-Thiazolyl)Benzimidazole (Thiabendazole).	Polydioxanone	90-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-72
11315341-4	2001	Both non-selective Cox-inhibitors and selective Cox-2 inhibitors induce renal side effects including sodium retention and reduction of the glomerular filtration rate.	Sodium	101-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-53
18475995-0	2001	Synthesis, Characterization and Antiproliferative Activity of the Co(II), Ni(II), Cu(II), Pd(II) and Pt(II) Complexes of 2-(4-Thiazolyl)Benzimidazole (Thiabendazole).	pt(ii)	101-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-72
21336918-2	2001	After activation of cellular phospholipases and release of free arachidonic acid, catalyzed insertion of oxygen occurs enzymatically via action of one of the two known cyclooxygenase isoenzymes (COX-1 and COX-2).	Arachidonic Acid	64-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	205-210
21336918-2	2001	After activation of cellular phospholipases and release of free arachidonic acid, catalyzed insertion of oxygen occurs enzymatically via action of one of the two known cyclooxygenase isoenzymes (COX-1 and COX-2).	Oxygen	105-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	205-210
21336918-11	2001	It is undergoing dioxygenation catalyzed by cyclooxygenase (either COX-1 or COX-2 isoforms) to form the unstable endoperoxide intermediate PGH2.	endoperoxide	113-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-81
21336918-11	2001	It is undergoing dioxygenation catalyzed by cyclooxygenase (either COX-1 or COX-2 isoforms) to form the unstable endoperoxide intermediate PGH2.	Prostaglandin H2	139-143	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-81
18475995-0	2001	Synthesis, Characterization and Antiproliferative Activity of the Co(II), Ni(II), Cu(II), Pd(II) and Pt(II) Complexes of 2-(4-Thiazolyl)Benzimidazole (Thiabendazole).	Thiabendazole	121-149	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-72
18475995-0	2001	Synthesis, Characterization and Antiproliferative Activity of the Co(II), Ni(II), Cu(II), Pd(II) and Pt(II) Complexes of 2-(4-Thiazolyl)Benzimidazole (Thiabendazole).	Thiabendazole	151-164	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-72
18475995-1	2001	Complexes of 2-(4-thiazolyi)benzimidazole (thiabendazole, THBD) with Co(II), Ni(II), Cu(ll) of general formula ML(2)(NO(3))(2) H(2)O and complexes of Pd(II) and Pt(II) of general formula ML2Cl(2) H(2)O have been obtained and characterized by elemental analyses, IR and far IR spectroscopy and magnetic measurements.	2-(4-thiazolyi)benzimidazole	13-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-75
18475995-1	2001	Complexes of 2-(4-thiazolyi)benzimidazole (thiabendazole, THBD) with Co(II), Ni(II), Cu(ll) of general formula ML(2)(NO(3))(2) H(2)O and complexes of Pd(II) and Pt(II) of general formula ML2Cl(2) H(2)O have been obtained and characterized by elemental analyses, IR and far IR spectroscopy and magnetic measurements.	Thiabendazole	43-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-75
11552047-3	2001	These enzymes (Cox-1 and Cox-2) catalyze the synthesis of eicosanoids, which play an important part in platelet-vessel wall interactions.	Eicosanoids	58-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-30
11326316-9	2001	Indomethacin and celecoxib reversed the EGF- and LPS-dependent COX-2, VEGF, and PGE2 increases.	Indomethacin	0-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-68
11326316-9	2001	Indomethacin and celecoxib reversed the EGF- and LPS-dependent COX-2, VEGF, and PGE2 increases.	Celecoxib	17-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-68
11552047-6	2001	Conversely, Cox-2 controls the synthesis of prostacyclin (PGI2), a local platelet regulator with an effect opposite to that of Tx-A2.	Epoprostenol	44-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-17
11552047-6	2001	Conversely, Cox-2 controls the synthesis of prostacyclin (PGI2), a local platelet regulator with an effect opposite to that of Tx-A2.	Epoprostenol	58-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-17
11552047-8	2001	Aspirin is a more potent inhibitor of Cox-1 than of Cox-2, unlike other non-steroidal anti-inflammatory drugs (NSAIDs), which have limited selectivity.	Aspirin	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-57
11268132-6	2001	Other transition metal ions, such as NiII, ZnII, CoII and CuII, also show distinctive metal-assisted reactions.	Metals	17-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-53
17986975-4	2001	The basic mechanism of their action is based on the inhibition of the enzyme cascade in the metabolism of arachidonid acid - cyclooxygenase 1 (COX-1) and cyclooxygenase 2 (COX-2) - and as a result inhibition of prostaglandin production.	Prostaglandins	211-224	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	172-177
11273789-5	2001	Eight adult subjects with stable asthma underwent spirometry, bronchoprovocation challenge with methacholine, and cough challenge testing with capsaicin, before and after a 7 day course of the COX-2 inhibitor celecoxib (200 mg orally, twice daily) and placebo, in a randomized, double-blind, crossover fashion.	Celecoxib	209-218	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	193-198
11268132-6	2001	Other transition metal ions, such as NiII, ZnII, CoII and CuII, also show distinctive metal-assisted reactions.	Metals	86-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-53
11256140-3	2001	Celecoxib (Celebrex, Pharmacia) is a potent and selective inhibitor of the COX-2 isoform of cyclooxygenase which is used as nonsteroidal anti-inflammatory drug (NSAID).	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
11226025-4	2001	The NFkappaB pathway is important in the control of cytokine synthesis and can modulate production of chemokines, matrix metalloproteinases and the inducible prostaglandin synthesis enzyme COX-2.	Prostaglandins	158-171	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	189-194
11256140-3	2001	Celecoxib (Celebrex, Pharmacia) is a potent and selective inhibitor of the COX-2 isoform of cyclooxygenase which is used as nonsteroidal anti-inflammatory drug (NSAID).	Celecoxib	11-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
11118975-1	2000	The Co(II) ion lies on an inversion centre and is octahedrally coordinated to two trimesate anions and four water molecules.	trimesate anions	82-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
11252686-1	2001	OBJECTIVE: A clinical trial was conducted in 600 patients with OA of the knee to test the hypothesis that the specific COX-2 inhibitor, celecoxib, has equivalent efficacy and a superior tolerability/safety profile when compared to diclofenac, the current worldwide standard of care.	Celecoxib	136-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-124
11106490-9	2000	The only other metal ion to cause slight activation of the enzyme was Co(II), with Ca(II), Cu(II), Mg(II), Ni(II), and Zn(II) all being inhibitory.	Metals	15-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-76
11106490-9	2000	The only other metal ion to cause slight activation of the enzyme was Co(II), with Ca(II), Cu(II), Mg(II), Ni(II), and Zn(II) all being inhibitory.	ca(ii)	83-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-76
11106490-9	2000	The only other metal ion to cause slight activation of the enzyme was Co(II), with Ca(II), Cu(II), Mg(II), Ni(II), and Zn(II) all being inhibitory.	cu(ii)	91-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-76
11106490-9	2000	The only other metal ion to cause slight activation of the enzyme was Co(II), with Ca(II), Cu(II), Mg(II), Ni(II), and Zn(II) all being inhibitory.	mg(ii)	99-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-76
11106490-9	2000	The only other metal ion to cause slight activation of the enzyme was Co(II), with Ca(II), Cu(II), Mg(II), Ni(II), and Zn(II) all being inhibitory.	Nickel(2+)	107-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-76
11106490-9	2000	The only other metal ion to cause slight activation of the enzyme was Co(II), with Ca(II), Cu(II), Mg(II), Ni(II), and Zn(II) all being inhibitory.	Zinc	119-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-76
12120179-1	2001	One hundred years after the introduction of aspirin, greater understanding of the mechanism of action of NSAIDs has led to the development of selective COX-2 inhibitors.	Aspirin	44-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-157
11090967-0	2000	Inhibitory effects of 9-cis-retinoic acid and pyrrolidinedithiocarbamate on cyclooxygenase (COX)-2 expression and cell growth in human skin squamous carcinoma cells.	Alitretinoin	22-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-98
11090967-0	2000	Inhibitory effects of 9-cis-retinoic acid and pyrrolidinedithiocarbamate on cyclooxygenase (COX)-2 expression and cell growth in human skin squamous carcinoma cells.	pyrrolidine dithiocarbamic acid	46-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-98
11090967-1	2000	We recently demonstrated that the constitutive expression of cyclooxygenase (COX)-2 protein and prostaglandin E(2) (PGE(2)) biosynthesis were significantly enhanced in human skin epidermal cancer cells and that cancer cell growth was effectively inhibited by the suppression of COX-2 expression by transfection with COX-2 antisense oligonucleotide.	Oligonucleotides	332-347	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-83
11090967-4	2000	Treatment with a retinoid (9-cis-retinoic acid (9-cis-RA)) or an antioxidant (pyrrolidinedithiocarbamate (PDTC)) suppressed COX-2 expression and PGE(2) biosynthesis in a concentration-dependent manner.	Retinoids	17-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	124-129
11090967-4	2000	Treatment with a retinoid (9-cis-retinoic acid (9-cis-RA)) or an antioxidant (pyrrolidinedithiocarbamate (PDTC)) suppressed COX-2 expression and PGE(2) biosynthesis in a concentration-dependent manner.	Alitretinoin	27-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	124-129
11090967-4	2000	Treatment with a retinoid (9-cis-retinoic acid (9-cis-RA)) or an antioxidant (pyrrolidinedithiocarbamate (PDTC)) suppressed COX-2 expression and PGE(2) biosynthesis in a concentration-dependent manner.	Alitretinoin	48-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	124-129
11090967-4	2000	Treatment with a retinoid (9-cis-retinoic acid (9-cis-RA)) or an antioxidant (pyrrolidinedithiocarbamate (PDTC)) suppressed COX-2 expression and PGE(2) biosynthesis in a concentration-dependent manner.	pyrrolidine dithiocarbamic acid	78-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	124-129
11090967-4	2000	Treatment with a retinoid (9-cis-retinoic acid (9-cis-RA)) or an antioxidant (pyrrolidinedithiocarbamate (PDTC)) suppressed COX-2 expression and PGE(2) biosynthesis in a concentration-dependent manner.	pyrrolidine dithiocarbamic acid	106-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	124-129
11128651-1	2000	Metabolites of the COX-2 inhibitor rofecoxib (MK-0966, Vioxx) were prepared by synthetic or biosynthetic methods.	rofecoxib	35-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-24
11128651-1	2000	Metabolites of the COX-2 inhibitor rofecoxib (MK-0966, Vioxx) were prepared by synthetic or biosynthetic methods.	rofecoxib	46-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-24
11128651-1	2000	Metabolites of the COX-2 inhibitor rofecoxib (MK-0966, Vioxx) were prepared by synthetic or biosynthetic methods.	rofecoxib	55-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-24
11118975-1	2000	The Co(II) ion lies on an inversion centre and is octahedrally coordinated to two trimesate anions and four water molecules.	Water	108-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
11201045-11	2000	Analysis of these data suggests that COX-2-derived PGE2 down-regulates ICAM-1 expression via EP2/EP4 receptors in IL-1beta-stimulated HGF.	Dinoprostone	51-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-42
11211927-7	2000	Using the mean of the results for PGE2 and TXB2 inhibition, the COX-1/COX-2 ratios of the IC50 values for aspirin and NS-398 are < 0.1 and > 130, respectively.	Aspirin	106-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-75
11211927-7	2000	Using the mean of the results for PGE2 and TXB2 inhibition, the COX-1/COX-2 ratios of the IC50 values for aspirin and NS-398 are < 0.1 and > 130, respectively.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	118-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-75
11211927-9	2000	Dose responses to aspirin and NS-398 which are COX- and COX-2 selective inhibitors respectively, confirmed the utility of this system.	Aspirin	18-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-61
11211927-9	2000	Dose responses to aspirin and NS-398 which are COX- and COX-2 selective inhibitors respectively, confirmed the utility of this system.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	30-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-61
11201045-1	2000	Prostaglandin E2 (PGE2), which exerts its actions via EP receptors (EP1, EP2, EP3, and EP4), is a bioactive metabolite of arachidonic acid produced by cyclooxygenase (COX)-1 and/or COX-2.	Dinoprostone	0-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	181-186
11112151-2	2000	Treatment with exogenous PGE(2) resulted in enhanced expression of IL-1 beta-induced COX-2 protein and messenger RNA (mRNA) as compared with the effect of the cytokine per se.	Prostaglandins E	25-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-90
11112151-3	2000	Inhibition of PGE(2) production with a nonselective COX inhibitor (flurbiprofen, 10 microM) resulted in a significant reduction in IL-1 beta- induced COX-2 expression, supporting a role of endogenous COX metabolites in the modulation of COX-2 expression.	Dinoprostone	14-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	150-155
11112151-3	2000	Inhibition of PGE(2) production with a nonselective COX inhibitor (flurbiprofen, 10 microM) resulted in a significant reduction in IL-1 beta- induced COX-2 expression, supporting a role of endogenous COX metabolites in the modulation of COX-2 expression.	Dinoprostone	14-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	237-242
11112151-3	2000	Inhibition of PGE(2) production with a nonselective COX inhibitor (flurbiprofen, 10 microM) resulted in a significant reduction in IL-1 beta- induced COX-2 expression, supporting a role of endogenous COX metabolites in the modulation of COX-2 expression.	Flurbiprofen	67-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	150-155
11112151-3	2000	Inhibition of PGE(2) production with a nonselective COX inhibitor (flurbiprofen, 10 microM) resulted in a significant reduction in IL-1 beta- induced COX-2 expression, supporting a role of endogenous COX metabolites in the modulation of COX-2 expression.	Flurbiprofen	67-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	237-242
11112151-5	2000	Treatment with cycloheximide to inhibit translation, and with dexamethasone or actinomycin D to inhibit transcription, linked the effect of PGE(2) to the transcriptional level of COX-2 mRNA rather than to a potential effect on protein and/or mRNA stabilization.	Cycloheximide	15-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	179-184
11112151-5	2000	Treatment with cycloheximide to inhibit translation, and with dexamethasone or actinomycin D to inhibit transcription, linked the effect of PGE(2) to the transcriptional level of COX-2 mRNA rather than to a potential effect on protein and/or mRNA stabilization.	Prostaglandins E	140-143	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	179-184
11112151-6	2000	PGE(2) increased adenylate cyclase activity in a concentration dependent manner, and forskolin, a direct activator of adenylate cyclase, caused a marked increase in IL-1 beta-dependent COX-2, suggesting the existence of a causal relationship between the two events.	Prostaglandins E	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	185-190
11112151-6	2000	PGE(2) increased adenylate cyclase activity in a concentration dependent manner, and forskolin, a direct activator of adenylate cyclase, caused a marked increase in IL-1 beta-dependent COX-2, suggesting the existence of a causal relationship between the two events.	Colforsin	85-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	185-190
11112151-8	2000	The effect of PGE(2) on COX-2 expression may contribute to the hypothesized antiinflammatory role of PGE(2) in human airways, providing a self-amplifying loop leading to increased biosynthesis of PGE(2) during an inflammatory event.	Prostaglandins E	14-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
11112151-8	2000	The effect of PGE(2) on COX-2 expression may contribute to the hypothesized antiinflammatory role of PGE(2) in human airways, providing a self-amplifying loop leading to increased biosynthesis of PGE(2) during an inflammatory event.	Prostaglandins E	101-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
11112151-8	2000	The effect of PGE(2) on COX-2 expression may contribute to the hypothesized antiinflammatory role of PGE(2) in human airways, providing a self-amplifying loop leading to increased biosynthesis of PGE(2) during an inflammatory event.	Prostaglandins E	101-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
11118042-7	2000	Sulindac sulfone inhibited COX-2 protein expression, which resulted in a decrease in prostaglandin synthase E2 production.	sulindac sulfone	0-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-32
11201045-1	2000	Prostaglandin E2 (PGE2), which exerts its actions via EP receptors (EP1, EP2, EP3, and EP4), is a bioactive metabolite of arachidonic acid produced by cyclooxygenase (COX)-1 and/or COX-2.	Dinoprostone	18-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	181-186
11201045-1	2000	Prostaglandin E2 (PGE2), which exerts its actions via EP receptors (EP1, EP2, EP3, and EP4), is a bioactive metabolite of arachidonic acid produced by cyclooxygenase (COX)-1 and/or COX-2.	Arachidonic Acid	122-138	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	181-186
11201045-4	2000	NS-398, a specific COX-2 inhibitor, completely inhibited PGE2 production by IL-1beta-stimulated HGF, as did indomethacin, a COX-1/COX-2 inhibitor.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	0-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-24
11201045-4	2000	NS-398, a specific COX-2 inhibitor, completely inhibited PGE2 production by IL-1beta-stimulated HGF, as did indomethacin, a COX-1/COX-2 inhibitor.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	0-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	130-135
11201045-4	2000	NS-398, a specific COX-2 inhibitor, completely inhibited PGE2 production by IL-1beta-stimulated HGF, as did indomethacin, a COX-1/COX-2 inhibitor.	Dinoprostone	57-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-24
11201045-4	2000	NS-398, a specific COX-2 inhibitor, completely inhibited PGE2 production by IL-1beta-stimulated HGF, as did indomethacin, a COX-1/COX-2 inhibitor.	Indomethacin	108-120	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	130-135
11133013-5	2000	NO and PGE2 reduction was the consequence of the inhibition on iNOS and COX-2 expression because it did not affect inducible nitric oxide synthase and cyclooxygenase-2 activities in intact cells.	Dinoprostone	7-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
11095494-0	2000	Kainic acid rapidly induces cyclooxygenase (COX)-2 in piglet cerebral cortex.	Kainic Acid	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-50
11062012-0	2000	Ceramide induction of COX-2 and PGE(2) in pulmonary A549 cells does not involve activation of NF-kappaB.	Ceramides	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-27
11062012-3	2000	Ceramide and SMase both induced cyclooxygenase (COX)-2 protein expression and stimulated PGE(2) release.	Ceramides	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-54
11276798-1	2000	Celecoxib is the first COX-2-specific inhibitor approved for relief of the signs and symptoms of osteoarthritis (OA) and rheumatoid arthritis (RA), as well as for treatment of familial adenomatous polyposis.	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-28
11103814-0	2000	Differential effects of theaflavin monogallates on cell growth, apoptosis, and Cox-2 gene expression in cancerous versus normal cells.	theaflavin	24-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-84
11103814-8	2000	Among the tea polyphenols tested, TF-2 and, to a lesser degree, (-)-epigallocatechin gallate inhibited cyclooxygenase (Cox)-2 gene expression.	Polyphenols	14-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-125
11103814-8	2000	Among the tea polyphenols tested, TF-2 and, to a lesser degree, (-)-epigallocatechin gallate inhibited cyclooxygenase (Cox)-2 gene expression.	epigallocatechin gallate	64-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-125
11053030-4	2000	The p38 inhibitor SB-203580 (3 microM) decreased IL-1 beta-induced COX-2 by 70 +/- 7% (P < 0.01).	SB 203580	18-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-72
11062174-8	2000	Simultaneous treatment with Zn(II) prevented largely the inhibition induced by Cd(II), Co(II), and Ni(II), but only slightly in the case of Cu(II).	Zinc	28-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-92
11151817-6	2000	Whereas many of the side effects of NSAIDs (e.g. gastrointestinal ulceration and bleeding, platelet dysfunctions) are due to a suppression of COX-1 activity, inhibition of COX-2-derived prostanoids facilitates the anti-inflammatory, analgesic and antipyretic effects of NSAIDs.	Prostaglandins	186-197	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	172-177
11151817-10	2000	The present review assesses concept and molecular mechanism underlying specific COX-2 inhibition as well as indications, pharmakokinetics and unwanted side effects of the recently approved specific COX-2 inhibitors celecoxib and rofecoxib.	Celecoxib	215-224	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	198-203
11151817-10	2000	The present review assesses concept and molecular mechanism underlying specific COX-2 inhibition as well as indications, pharmakokinetics and unwanted side effects of the recently approved specific COX-2 inhibitors celecoxib and rofecoxib.	rofecoxib	229-238	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	198-203
11058524-7	2000	Levels of mRNA encoding COX-2 were undetectable in corpora lutea collected on Day 13 of the estrous cycle but were 11 +/- 4 and 44 +/- 28 amol/microgram poly(A)(+) RNA in corpora lutea collected on Day 4 of the estrous cycle and Day 13 of pregnancy, respectively.	Poly A	153-160	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
11138599-4	2000	[symbol: see text]Rofecoxib (Vioxx--MSD) and [symbol: see text]celecoxib (Celebrex--Searle) have been developed as selective inhibitors of COX-2.	rofecoxib	18-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-144
11085526-6	2000	The cytotoxic effects of high-dose celecoxib were independent of COX-2 inhibition because similar effects were observed in cox-2 (+/+), cox-2 (+/-) and cox-2 (-/-) fibroblasts.	Celecoxib	35-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-128
11085526-6	2000	The cytotoxic effects of high-dose celecoxib were independent of COX-2 inhibition because similar effects were observed in cox-2 (+/+), cox-2 (+/-) and cox-2 (-/-) fibroblasts.	Celecoxib	35-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	136-141
11085526-6	2000	The cytotoxic effects of high-dose celecoxib were independent of COX-2 inhibition because similar effects were observed in cox-2 (+/+), cox-2 (+/-) and cox-2 (-/-) fibroblasts.	Celecoxib	35-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	136-141
11102559-6	2000	COX-1 generates prostaglandins with physiological functions, COX-2 is induced by inflammation and its physiologic functions are unclear at present.	Prostaglandins	16-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-66
11102560-3	2000	The recognition that the inducible isoform COX-2 was associated with inflammation and arthritis led to the hypothesis that PGs produced by a COX-2-dependent pathway were responsible for the inflammation, pain, and tissue destruction.	Phosphatidylglycerols	123-126	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
11102560-3	2000	The recognition that the inducible isoform COX-2 was associated with inflammation and arthritis led to the hypothesis that PGs produced by a COX-2-dependent pathway were responsible for the inflammation, pain, and tissue destruction.	Phosphatidylglycerols	123-126	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	141-146
11102561-3	2000	The discovery of two COX-isoenzymes, a constitutive COX-1, serving homeostatic prostanoid synthesis, and an inducible COX-2, responsible for proinflammatory prosta noid production, led to the development of new NSAIDs: Preferential and specific COX-2 inhibitors, promising minimal NSAID-typical toxicity with equivalent efficacy.	Prostaglandins	79-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	245-250
11102561-6	2000	Animal experiments and clinical trials with preferential and specific COX-2 inhibitors revealed that COX-2 is the critical enzyme for sodium excretion, renin release and likely antagonism of antidiuretic hormone.	Sodium	134-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-75
11102561-6	2000	Animal experiments and clinical trials with preferential and specific COX-2 inhibitors revealed that COX-2 is the critical enzyme for sodium excretion, renin release and likely antagonism of antidiuretic hormone.	Sodium	134-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-106
11102561-9	2000	In summary, the gain of renal safety by use of preferential or specific COX-2 inhibitors is small or negligible with respect to sodium retention, hyperkalemia and probably water intoxication.	Sodium	128-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
10942778-9	2000	Production of cAMP by S1P was abolished by NS-398, a selective inhibitor of COX-2.	Cyclic AMP	14-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-81
10942778-9	2000	Production of cAMP by S1P was abolished by NS-398, a selective inhibitor of COX-2.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	43-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-81
10942778-11	2000	Blocking COX-2 by NS-398 blunted the antiproliferative effect of S1P.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	18-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	9-14
10942778-12	2000	We conclude that S1P inhibits proliferation of hMF, probably via an intracellular mechanism, through early COX-2-dependent release of prostaglandin E(2) and cAMP, and delayed COX-2 induction.	Prostaglandins E	134-149	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-112
10942778-12	2000	We conclude that S1P inhibits proliferation of hMF, probably via an intracellular mechanism, through early COX-2-dependent release of prostaglandin E(2) and cAMP, and delayed COX-2 induction.	Cyclic AMP	157-161	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-112
11032962-3	2000	The discovery of two COX isoenzymes, COX-1 and COX-2, and the detection of their separate function and regulation, has initiated the search for new and putatively more selective inhibitors of prostaglandin biosynthesis.	Prostaglandins	192-205	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
11032962-5	2000	Available experimental and clinical data of selective COX-2 inhibitors, including flosulide, celecoxib or rofecoxib, suggest improved gastric tolerance as compared to conventional, non-selective NSAIDs.	flosulide	82-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-59
11032962-5	2000	Available experimental and clinical data of selective COX-2 inhibitors, including flosulide, celecoxib or rofecoxib, suggest improved gastric tolerance as compared to conventional, non-selective NSAIDs.	Celecoxib	93-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-59
11032962-5	2000	Available experimental and clinical data of selective COX-2 inhibitors, including flosulide, celecoxib or rofecoxib, suggest improved gastric tolerance as compared to conventional, non-selective NSAIDs.	rofecoxib	106-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-59
11032962-7	2000	COX-2-selective compounds at anti-inflammatory doses might have other side-effects, and for example reduce vascular prostacyclin production.	Epoprostenol	116-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
11060833-1	2000	Parecoxib is a prodrug of valdecoxib, which is a potent and selective inhibitor of COX-2.	parecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
11060833-1	2000	Parecoxib is a prodrug of valdecoxib, which is a potent and selective inhibitor of COX-2.	valdecoxib	26-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
11138599-4	2000	[symbol: see text]Rofecoxib (Vioxx--MSD) and [symbol: see text]celecoxib (Celebrex--Searle) have been developed as selective inhibitors of COX-2.	rofecoxib	29-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-144
11138599-4	2000	[symbol: see text]Rofecoxib (Vioxx--MSD) and [symbol: see text]celecoxib (Celebrex--Searle) have been developed as selective inhibitors of COX-2.	Celecoxib	63-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-144
11138599-4	2000	[symbol: see text]Rofecoxib (Vioxx--MSD) and [symbol: see text]celecoxib (Celebrex--Searle) have been developed as selective inhibitors of COX-2.	Celecoxib	74-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-144
11138599-6	2000	The manufacturer claims that "in clinical studies rofecoxib inhibits COX-2 but not COX-1", has "the power of high-dose NSAIDs--diclofenac and ibuprofen" and "superior GI safety profile compared to conventional NSAIDs".	rofecoxib	50-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-74
17018963-13	2000	New aspirinlike drugs with selective COX 2 blocking effect are apparently not any better on classical indications than the older drugs with mixed COX 1 and COX 2 blocking effect and their use might moreover be limited by some severe side effects.	aspirinlike	4-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-42
11074321-1	2000	We initially observed a phenomenon of reduced in vitro binding of exogenous cobalt [Co(II)] to the N-terminus of human serum albumin (HSA) in emergency chest pain patients with early onset unstable angina and myocardial infarction.	Cobalt	76-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-90
11079466-3	2000	The inhibition of COX-2 expression could help prevent prostaglandin E2 secretion, followed by osteoclast activation for bone destruction and resorption.	Dinoprostone	54-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-23
11079466-4	2000	We examined whether the antioxidant N-acetylcysteine (NAC) inhibited COX-2 expression induced in the human osteoblastic cell line MG63 by interleukin-1beta (IL-1beta).	Acetylcysteine	36-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-74
11079466-4	2000	We examined whether the antioxidant N-acetylcysteine (NAC) inhibited COX-2 expression induced in the human osteoblastic cell line MG63 by interleukin-1beta (IL-1beta).	Acetylcysteine	54-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-74
11079466-5	2000	According to Western blot and reverse transcription-polymerase chain reaction (RT-PCR) test results, NAC inhibited IL-1beta-induced COX-2 expression in protein and messenger RNA.	Acetylcysteine	101-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-137
11079466-7	2000	These results suggested that NAC inhibited both COX-2 expression and NFkappaB nuclear translocation in MG63, which in turn indicated that NAC could inhibit the inflammatory process involved in bone resorption by regulating COX-2 expression at the level of transcription.	Acetylcysteine	29-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-53
11079466-7	2000	These results suggested that NAC inhibited both COX-2 expression and NFkappaB nuclear translocation in MG63, which in turn indicated that NAC could inhibit the inflammatory process involved in bone resorption by regulating COX-2 expression at the level of transcription.	Acetylcysteine	29-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	223-228
11079466-7	2000	These results suggested that NAC inhibited both COX-2 expression and NFkappaB nuclear translocation in MG63, which in turn indicated that NAC could inhibit the inflammatory process involved in bone resorption by regulating COX-2 expression at the level of transcription.	mg63	103-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-53
11079466-7	2000	These results suggested that NAC inhibited both COX-2 expression and NFkappaB nuclear translocation in MG63, which in turn indicated that NAC could inhibit the inflammatory process involved in bone resorption by regulating COX-2 expression at the level of transcription.	mg63	103-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	223-228
11079466-7	2000	These results suggested that NAC inhibited both COX-2 expression and NFkappaB nuclear translocation in MG63, which in turn indicated that NAC could inhibit the inflammatory process involved in bone resorption by regulating COX-2 expression at the level of transcription.	Acetylcysteine	138-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-53
11079466-7	2000	These results suggested that NAC inhibited both COX-2 expression and NFkappaB nuclear translocation in MG63, which in turn indicated that NAC could inhibit the inflammatory process involved in bone resorption by regulating COX-2 expression at the level of transcription.	Acetylcysteine	138-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	223-228
11395328-0	2000	Evaluation of scavenging activity assessed by Co(II)/EDTA-induced luminol chemiluminescence and DPPH* (2,2-diphenyl-1-picrylhydrazyl) free radical assay.	Luminol	66-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-52
11395328-1	2000	The scavenging activities of three standard antioxidants, quercetin, ascorbic acid, and trolox, were evaluated by Co(II)/ethylenediamine-tetraacetic acid (EDTA)-induced luminol chemiluminescence and the 2,2-diphenyl-1-picrylhydrazyl (DPPH*) free radical assay.	6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid	88-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-120
11395328-1	2000	The scavenging activities of three standard antioxidants, quercetin, ascorbic acid, and trolox, were evaluated by Co(II)/ethylenediamine-tetraacetic acid (EDTA)-induced luminol chemiluminescence and the 2,2-diphenyl-1-picrylhydrazyl (DPPH*) free radical assay.	Luminol	169-176	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-120
11395328-2	2000	Therefore, the aim of this study was to characterise an enzyme-free and time-independent chemiluminescence method for the assessment of the scavenging profile of compounds in a cell-free system using the Co(II)/EDTA-luminol-peroxide system.	Edetic Acid	211-215	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	204-210
11395328-2	2000	Therefore, the aim of this study was to characterise an enzyme-free and time-independent chemiluminescence method for the assessment of the scavenging profile of compounds in a cell-free system using the Co(II)/EDTA-luminol-peroxide system.	Luminol	216-223	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	204-210
11395328-2	2000	Therefore, the aim of this study was to characterise an enzyme-free and time-independent chemiluminescence method for the assessment of the scavenging profile of compounds in a cell-free system using the Co(II)/EDTA-luminol-peroxide system.	Peroxides	224-232	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	204-210
11395328-3	2000	These results showed that the three standards were efficient and effective in inhibiting both Co(II)/EDTA-induced luminol chemiluminescence and the free radical DPPH*.	Edetic Acid	101-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-100
11395328-3	2000	These results showed that the three standards were efficient and effective in inhibiting both Co(II)/EDTA-induced luminol chemiluminescence and the free radical DPPH*.	Luminol	114-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-100
11395328-3	2000	These results showed that the three standards were efficient and effective in inhibiting both Co(II)/EDTA-induced luminol chemiluminescence and the free radical DPPH*.	1,1-diphenyl-2-picrylhydrazyl	161-165	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-100
11395328-5	2000	The present study has applied a simple and precise procedure for the study of hydroxyl radical scavenging activity by Co(II)/EDTA-induced luminol chemiluminescence, and this was assessed by DPPH* free radical scavenging.	Hydroxyl Radical	78-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-124
11395328-5	2000	The present study has applied a simple and precise procedure for the study of hydroxyl radical scavenging activity by Co(II)/EDTA-induced luminol chemiluminescence, and this was assessed by DPPH* free radical scavenging.	Edetic Acid	125-129	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-124
11395328-5	2000	The present study has applied a simple and precise procedure for the study of hydroxyl radical scavenging activity by Co(II)/EDTA-induced luminol chemiluminescence, and this was assessed by DPPH* free radical scavenging.	Luminol	138-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-124
17018963-12	2000	All aspirinlike drugs have until quite recently been mixed blockers of cyclooxigenases (COX 1 and COX 2) with aspirin itself being the most outstanding COX 1 blocker.	aspirinlike	4-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-103
17018963-12	2000	All aspirinlike drugs have until quite recently been mixed blockers of cyclooxigenases (COX 1 and COX 2) with aspirin itself being the most outstanding COX 1 blocker.	Aspirin	4-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-103
10931854-4	2000	Here we report that 2-AG is a substrate for COX-2 and that it is metabolized as effectively as arachidonic acid.	glyceryl 2-arachidonate	20-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-49
11228540-2	2000	Cyclooxygenase (COX), the rate-limiting enzyme in PG biosynthesis, exists in two isoforms, COX-1 and COX-2.	Prostaglandins	50-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-106
11228540-4	2000	We have previously shown that COX-2-derived prostacyclin participates in blastocyst implantation through activation of peroxisome proliferator activated receptor delta (PPARdelta), a member of the nuclear hormone receptor family.	Epoprostenol	44-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-35
11109595-3	2000	Because the prostanoids produced by COX-1 appear to play a physiological role (protection of the gastric mucosa, platelet aggregation, vascular homeostasis, maintenance of renal sodium-water balance) while those produced by COX-2 seem mainly to intervene in the inflammatory response and in certain processes associated with cell proliferation, the hypothesis has been put forward that the NSAIDs that are selective COX-2 inhibitors should theoretically be capable of maintaining NSAID therapeutic properties but also have fewer adverse side effects due to the maintenance of prostaglandin production at normal physiological levels.	Prostaglandins	576-589	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	224-229
11090259-7	2000	However, immunoreactivity of COX-2/nitrotyrosine was observed in all cases with intestinal metaplasia even after the cure of H. pylori infection.Thus, cure of H. pylori infection may decrease the risk of gastric carcinogenesis due to COX-2 and NO-related compounds in gastric mucosa but not in those patients with intestinal metaplasia.	3-nitrotyrosine	35-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34
11090259-7	2000	However, immunoreactivity of COX-2/nitrotyrosine was observed in all cases with intestinal metaplasia even after the cure of H. pylori infection.Thus, cure of H. pylori infection may decrease the risk of gastric carcinogenesis due to COX-2 and NO-related compounds in gastric mucosa but not in those patients with intestinal metaplasia.	3-nitrotyrosine	35-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	234-239
11080685-1	2000	Arachidonic acid (AA) released by cPLA(2) and sPLA(2)s is supplied to both COX-1 and COX-2 in the immediate, and predominantly to COX-2 in the delayed, PG-biosynthetic responses.	Arachidonic Acid	0-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-90
11080685-1	2000	Arachidonic acid (AA) released by cPLA(2) and sPLA(2)s is supplied to both COX-1 and COX-2 in the immediate, and predominantly to COX-2 in the delayed, PG-biosynthetic responses.	Arachidonic Acid	0-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	130-135
10931854-5	2000	COX-2-mediated 2-AG oxygenation provides the novel lipid, prostaglandin H(2) glycerol ester (PGH(2)-G), in vitro and in cultured macrophages.	prostaglandin h(2) glycerol ester	58-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
10931854-5	2000	COX-2-mediated 2-AG oxygenation provides the novel lipid, prostaglandin H(2) glycerol ester (PGH(2)-G), in vitro and in cultured macrophages.	pgh(2)-g	93-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
10931854-7	2000	Pharmacological studies reveal that macrophage production of PGD(2)-G from endogenous sources of 2-AG is calcium-dependent and mediated by diacylglycerol lipase and COX-2.	pgd(2)-g	61-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	165-170
10931854-7	2000	Pharmacological studies reveal that macrophage production of PGD(2)-G from endogenous sources of 2-AG is calcium-dependent and mediated by diacylglycerol lipase and COX-2.	glyceryl 2-arachidonate	97-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	165-170
10931854-7	2000	Pharmacological studies reveal that macrophage production of PGD(2)-G from endogenous sources of 2-AG is calcium-dependent and mediated by diacylglycerol lipase and COX-2.	Calcium	105-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	165-170
10931854-8	2000	These results identify a distinct function for COX-2 in endocannabinoid metabolism and in the generation of a new family of prostaglandins derived from diacylglycerol and 2-AG.	Prostaglandins	124-138	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
10931854-8	2000	These results identify a distinct function for COX-2 in endocannabinoid metabolism and in the generation of a new family of prostaglandins derived from diacylglycerol and 2-AG.	Diglycerides	152-166	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
10931854-8	2000	These results identify a distinct function for COX-2 in endocannabinoid metabolism and in the generation of a new family of prostaglandins derived from diacylglycerol and 2-AG.	glyceryl 2-arachidonate	171-175	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
10869354-4	2000	mPGES expression was markedly induced by proinflammatory stimuli in various tissues and cells and was down-regulated by dexamethasone, accompanied by changes in COX-2 expression and delayed PGE(2) generation.	Prostaglandins E	1-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	161-166
11059772-5	2000	Esophageal adenocarcinoma cell lines were treated with various concentrations of NS-398 (selective for COX-2 inhibition) and flurbiprofen (selective for COX-1 inhibition).	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	81-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-108
10869354-6	2000	mPGES was functionally coupled with COX-2 in marked preference to COX-1, particularly when the supply of arachidonic acid was limited.	Arachidonic Acid	105-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-41
10869354-10	2000	Thus, COX-2 and mPGES are essential components for delayed PGE(2) biosynthesis, which may be linked to inflammation, fever, osteogenesis, and even cancer.	Dinoprostone	59-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	6-11
11059772-9	2000	In contrast, treatment with COX-2-selective concentrations of NS-398 significantly suppressed cell growth and increased apoptosis in the cell lines that expressed COX-2 (SEG-1 and FLO), but not in the cell line that did not express COX-2 (BIC-1).	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	62-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
11059772-9	2000	In contrast, treatment with COX-2-selective concentrations of NS-398 significantly suppressed cell growth and increased apoptosis in the cell lines that expressed COX-2 (SEG-1 and FLO), but not in the cell line that did not express COX-2 (BIC-1).	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	62-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	163-168
11059772-9	2000	In contrast, treatment with COX-2-selective concentrations of NS-398 significantly suppressed cell growth and increased apoptosis in the cell lines that expressed COX-2 (SEG-1 and FLO), but not in the cell line that did not express COX-2 (BIC-1).	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	62-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	163-168
11196960-9	2000	The selection of 2,2-diphenyl-2-mercaptoacetic acid as ligand with reductive properties has afforded the first mononuclear complex containing a CoIIS2O2 core and thus an unprecedented model for Co(II)-substituted metalloproteins containing tetrahedral MS2O2 active sites.	2,2-diphenyl-2-mercaptoacetic acid	17-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	194-200
11196960-9	2000	The selection of 2,2-diphenyl-2-mercaptoacetic acid as ligand with reductive properties has afforded the first mononuclear complex containing a CoIIS2O2 core and thus an unprecedented model for Co(II)-substituted metalloproteins containing tetrahedral MS2O2 active sites.	coiis2o2	144-152	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	194-200
11196960-9	2000	The selection of 2,2-diphenyl-2-mercaptoacetic acid as ligand with reductive properties has afforded the first mononuclear complex containing a CoIIS2O2 core and thus an unprecedented model for Co(II)-substituted metalloproteins containing tetrahedral MS2O2 active sites.	ms2o2	252-257	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	194-200
11035064-5	2000	COX-2 is functional in MDC as a specific inhibitor, NS-398, significantly reduces PGE(2) production.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	52-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
11035064-5	2000	COX-2 is functional in MDC as a specific inhibitor, NS-398, significantly reduces PGE(2) production.	Dinoprostone	82-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
11035064-7	2000	However, with IFN-gamma present, sCD40L-stimulated PG metabolism is redirected to COX-2, and PGE(2) synthesis increases severalfold.	Prostaglandins	51-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
11035064-9	2000	PG produced through COX-2 also autoregulate IL-12, but the effects are dependent on the MDC maturation state.	Prostaglandins	0-2	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-25
11035064-11	2000	COX-2-mediated PG production impacts MDC function as maturing these cells in the presence of NS-398 yields MDC that stimulate significantly more IFN-gamma in an allogeneic mixed lymphocyte response than MDC matured without this inhibitor.	Prostaglandins	15-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
11035064-11	2000	COX-2-mediated PG production impacts MDC function as maturing these cells in the presence of NS-398 yields MDC that stimulate significantly more IFN-gamma in an allogeneic mixed lymphocyte response than MDC matured without this inhibitor.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	93-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
11078056-10	2000	NS-398 induces apoptosis in COX-2 expressing LNCaP prostate cancer cells and, surprisingly, in colon cancer S/KS cells that does not express COX-2.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	0-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
11004044-11	2000	These results suggest that LPS augmented halothane-induced cerebrocortical hyperemia by induction of iNOS and COX-2.	Halothane	41-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-115
11113024-3	2000	Because acetaminophen is a weak inhibitor in vitro of both cyclooxygenase (COX)-1 and COX-2, the possibility exists that it inhibits a so far unidentified form of COX, perhaps COX-3.	Acetaminophen	8-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-91
11113024-6	2000	Recently, a variant of COX-2 induced with high concentrations of nonsteroidal anti-inflammatory drugs was shown to be highly sensitive to inhibition by acetaminophen.	Acetaminophen	152-165	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-28
11078056-2	2000	COX-2 produces prostaglandins that inhibit apoptosis and stimulate angiogenesis and invasiveness.	Prostaglandins	15-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
11040187-9	2000	RESULTS: LTD(4) and LTB(4), but not LTC(4), caused a time- and dose-dependent increase in expression and/or membrane accumulation of COX-2, beta-catenin, and Bcl-2, as well as PGE(2) production.	Prostaglandins E	176-179	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	133-138
11078056-3	2000	Selective COX-2 inhibitors reduce prostaglandin synthesis, restore apoptosis, and inhibit cancer cell proliferation.	Prostaglandins	34-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
11078056-5	2000	In contrast, aspirin-like nonselective NSAIDs such as sulindac and indomethacin inhibit not only the enzymatic action of the highly inducible, proinflammatory COX-2 but the constitutively expressed, cytoprotective COX-1 as well.	Aspirin	13-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	159-164
11078056-5	2000	In contrast, aspirin-like nonselective NSAIDs such as sulindac and indomethacin inhibit not only the enzymatic action of the highly inducible, proinflammatory COX-2 but the constitutively expressed, cytoprotective COX-1 as well.	Sulindac	54-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	159-164
11078056-5	2000	In contrast, aspirin-like nonselective NSAIDs such as sulindac and indomethacin inhibit not only the enzymatic action of the highly inducible, proinflammatory COX-2 but the constitutively expressed, cytoprotective COX-1 as well.	Indomethacin	67-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	159-164
11078056-8	2000	Selective COX-2 inhibitors, such as meloxicam, celecoxib (SC-58635), and rofecoxib (MK-0966), are NSAIDs that have been modified chemically to preferentially inhibit COX-2 but not COX-1.	Meloxicam	36-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
11078056-8	2000	Selective COX-2 inhibitors, such as meloxicam, celecoxib (SC-58635), and rofecoxib (MK-0966), are NSAIDs that have been modified chemically to preferentially inhibit COX-2 but not COX-1.	Meloxicam	36-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	166-171
11078056-8	2000	Selective COX-2 inhibitors, such as meloxicam, celecoxib (SC-58635), and rofecoxib (MK-0966), are NSAIDs that have been modified chemically to preferentially inhibit COX-2 but not COX-1.	Celecoxib	47-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
11078056-8	2000	Selective COX-2 inhibitors, such as meloxicam, celecoxib (SC-58635), and rofecoxib (MK-0966), are NSAIDs that have been modified chemically to preferentially inhibit COX-2 but not COX-1.	Celecoxib	47-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	166-171
11078056-8	2000	Selective COX-2 inhibitors, such as meloxicam, celecoxib (SC-58635), and rofecoxib (MK-0966), are NSAIDs that have been modified chemically to preferentially inhibit COX-2 but not COX-1.	Celecoxib	58-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
11078056-8	2000	Selective COX-2 inhibitors, such as meloxicam, celecoxib (SC-58635), and rofecoxib (MK-0966), are NSAIDs that have been modified chemically to preferentially inhibit COX-2 but not COX-1.	Celecoxib	58-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	166-171
11078056-8	2000	Selective COX-2 inhibitors, such as meloxicam, celecoxib (SC-58635), and rofecoxib (MK-0966), are NSAIDs that have been modified chemically to preferentially inhibit COX-2 but not COX-1.	rofecoxib	73-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
11078056-8	2000	Selective COX-2 inhibitors, such as meloxicam, celecoxib (SC-58635), and rofecoxib (MK-0966), are NSAIDs that have been modified chemically to preferentially inhibit COX-2 but not COX-1.	rofecoxib	73-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	166-171
11078056-8	2000	Selective COX-2 inhibitors, such as meloxicam, celecoxib (SC-58635), and rofecoxib (MK-0966), are NSAIDs that have been modified chemically to preferentially inhibit COX-2 but not COX-1.	rofecoxib	84-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
11078056-8	2000	Selective COX-2 inhibitors, such as meloxicam, celecoxib (SC-58635), and rofecoxib (MK-0966), are NSAIDs that have been modified chemically to preferentially inhibit COX-2 but not COX-1.	rofecoxib	84-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	166-171
11078056-9	2000	For instance, meloxicam inhibits the growth of cultured colon cancer cells (HCA-7 and Moser-S) that express COX-2 but has no effect on HCT-116 tumor cells that do not express COX-2.	Meloxicam	14-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-113
11028250-8	2000	These data support the contention that rofecoxib is the only drug of the regimens tested that uniquely inhibits COX-2 without affecting COX-1.	rofecoxib	39-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-117
11063390-3	2000	The purpose of the present study was to investigate the contribution of COX-1 and COX-2 to PGE2 production by human peripheral blood monocytes that are stimulated with lipopolysaccharides (LPS) from periodontopathogenic bacteria.	Dinoprostone	91-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
11028250-0	2000	Comparative inhibitory activity of rofecoxib, meloxicam, diclofenac, ibuprofen, and naproxen on COX-2 versus COX-1 in healthy volunteers.	rofecoxib	35-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-101
11028250-0	2000	Comparative inhibitory activity of rofecoxib, meloxicam, diclofenac, ibuprofen, and naproxen on COX-2 versus COX-1 in healthy volunteers.	Diclofenac	57-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-101
11028250-0	2000	Comparative inhibitory activity of rofecoxib, meloxicam, diclofenac, ibuprofen, and naproxen on COX-2 versus COX-1 in healthy volunteers.	Ibuprofen	69-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-101
11028250-0	2000	Comparative inhibitory activity of rofecoxib, meloxicam, diclofenac, ibuprofen, and naproxen on COX-2 versus COX-1 in healthy volunteers.	Naproxen	84-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-101
11028250-1	2000	Steady-state inhibitory activity of rofecoxib (Vioxx) on COX-2 versus COX-1 was compared with that of commonly used nonsteroidal anti-inflammatory drugs (NSAIDs) in 76 healthy volunteers randomized to placebo, rofecoxib 12.5 mg qd, rofecoxib 25 mg qd, diclofenac 50 mg tid, ibuprofen 800 mg tid, sodium naproxen 550 mg bid, or meloxicam 15 mg qd.	rofecoxib	36-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-62
11028250-1	2000	Steady-state inhibitory activity of rofecoxib (Vioxx) on COX-2 versus COX-1 was compared with that of commonly used nonsteroidal anti-inflammatory drugs (NSAIDs) in 76 healthy volunteers randomized to placebo, rofecoxib 12.5 mg qd, rofecoxib 25 mg qd, diclofenac 50 mg tid, ibuprofen 800 mg tid, sodium naproxen 550 mg bid, or meloxicam 15 mg qd.	rofecoxib	47-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-62
10998305-2	2000	The tetrakis(1-methyl-4-pyridyl) porphyrin ion, H(2)TmPyP(4+), was immobilized on the matrix surface by an ion exchange reaction and then metallated in situ with Co(II), resulting in SiO(2)/TiO(2)/phosphate/CoTmPyP material.	tetrakis(1-methyl-4-pyridyl) porphyrin	4-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	162-168
10998305-2	2000	The tetrakis(1-methyl-4-pyridyl) porphyrin ion, H(2)TmPyP(4+), was immobilized on the matrix surface by an ion exchange reaction and then metallated in situ with Co(II), resulting in SiO(2)/TiO(2)/phosphate/CoTmPyP material.	h(2)tmpyp(4+)	48-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	162-168
11032097-1	2000	Arachidonic acid metabolism is governed by 2 isoforms of cyclooxygenase (COX), the constitutively expressed COX-1 and the inducible COX-2.	Arachidonic Acid	0-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-137
11032099-4	2000	It is now known that the constitutively expressed isoenzyme cyclooxygenase (COX)-1 catalyzes the synthesis of prostanoids that help to regulate normal physiologic processes, including GI mucosa protection, whereas the inducible isoenzyme COX-2 leads to the generation of prostaglandins that mediate inflammation, pain, and fever.	Prostaglandins	110-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	238-243
11032099-6	2000	The first COX-2 targeted agent approved by the US Food and Drug Administration (FDA) was celecoxib.	Celecoxib	89-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
11032099-7	2000	This article reviews the risks of GI complications associated with conventional NSAID use and compares these risks with that of the new COX-2 specific inhibitor celecoxib.	Celecoxib	161-170	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	136-141
11063390-8	2000	Indomethacin, a non-selective COX-1/COX-2 inhibitor, and NS-398, a specific COX-2 inhibitor, completely inhibited PGE2 production.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	57-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-81
11063390-8	2000	Indomethacin, a non-selective COX-1/COX-2 inhibitor, and NS-398, a specific COX-2 inhibitor, completely inhibited PGE2 production.	Dinoprostone	114-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-81
11063390-12	2000	CONCLUSIONS: These results suggest that COX-2 is induced in monocytes stimulated with LPS derived from A. actinomycetemcomitans and P. gingivalis and that the COX-2 is primarily responsible for PGE2 production.	Dinoprostone	194-198	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
11063390-12	2000	CONCLUSIONS: These results suggest that COX-2 is induced in monocytes stimulated with LPS derived from A. actinomycetemcomitans and P. gingivalis and that the COX-2 is primarily responsible for PGE2 production.	Dinoprostone	194-198	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	159-164
11063390-13	2000	COX-2 may be pivotal in PGE2 production in periodontal lesions and may be involved in inflammatory responses.	Dinoprostone	24-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
10979111-4	2000	OBJECTIVE: To determine whether celecoxib, a COX-2-specific inhibitor, is associated with a lower incidence of significant upper GI toxic effects and other adverse effects compared with conventional NSAIDs.	Celecoxib	32-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-50
11043057-0	2000	[Rofecoxib, a new NSAID preparation with selective COX-2 inhibition].	rofecoxib	1-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-56
11043057-6	2000	A new NSAID, rofecoxib, has selective COX-2 inhibition defined as inhibition of COX-2, but not COX-1 in the therapeutic dose range.	rofecoxib	13-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-43
11043057-6	2000	A new NSAID, rofecoxib, has selective COX-2 inhibition defined as inhibition of COX-2, but not COX-1 in the therapeutic dose range.	rofecoxib	13-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-85
10975859-6	2000	Furthermore, the selective inhibition of cyclooxygenase (COX)-2 by NS-398 or the inhibition of COX-1/COX-2 by indomethacin blocked the SNP-induced cell death.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	67-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-63
10975859-6	2000	Furthermore, the selective inhibition of cyclooxygenase (COX)-2 by NS-398 or the inhibition of COX-1/COX-2 by indomethacin blocked the SNP-induced cell death.	Indomethacin	110-122	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-106
10992560-0	2000	The importance of COX-2 inhibition for aspirin induced asthma.	Aspirin	39-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-23
10996026-1	2000	T614 (3-formylamino-7-methylsulfonylamino-6-phenoxy-4H-1-benzopyran-4-o ne) is a member of the family of methanesulfonanilide non-steroidal anti-inflammatory drugs (mNSAIDs), most of which act as cyclooxygenase (COX)-2 inhibitors.	T 614	0-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	196-218
10866999-3	2000	Here, we report that flufenamic acid shows two opposing effects on COX-2 expression; it induces COX-2 expression in the colon cancer cell line (HT-29) and macrophage cell line (RAW 264.7); conversely, it inhibits tumor necrosis factor alpha (TNFalpha)- or lipopolysaccharide (LPS)-induced COX-2 expression.	Flufenamic Acid	21-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-72
10866999-3	2000	Here, we report that flufenamic acid shows two opposing effects on COX-2 expression; it induces COX-2 expression in the colon cancer cell line (HT-29) and macrophage cell line (RAW 264.7); conversely, it inhibits tumor necrosis factor alpha (TNFalpha)- or lipopolysaccharide (LPS)-induced COX-2 expression.	Flufenamic Acid	21-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-101
10866999-3	2000	Here, we report that flufenamic acid shows two opposing effects on COX-2 expression; it induces COX-2 expression in the colon cancer cell line (HT-29) and macrophage cell line (RAW 264.7); conversely, it inhibits tumor necrosis factor alpha (TNFalpha)- or lipopolysaccharide (LPS)-induced COX-2 expression.	Flufenamic Acid	21-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-101
10866999-7	2000	An activator of peroxisome proliferator-activated receptor gamma, 15-deoxy-Delta(12,14)-prostaglandin J(2), also induces COX-2 expression and inhibits TNFalpha-induced NFkappaB activation and COX-2 expression.	15-deoxy-delta(12,14)-prostaglandin j	66-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-126
10866999-7	2000	An activator of peroxisome proliferator-activated receptor gamma, 15-deoxy-Delta(12,14)-prostaglandin J(2), also induces COX-2 expression and inhibits TNFalpha-induced NFkappaB activation and COX-2 expression.	15-deoxy-delta(12,14)-prostaglandin j	66-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	192-197
10866999-10	2000	Furthermore, the results suggest that the anti-inflammatory effects of flufenamic acid and some other NSAIDs are due to their inhibitory action on the mitogen-induced expression of COX-2 and downstream markers of inflammation in addition to their inhibitory effect on COX enzyme activity.	Flufenamic Acid	71-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	181-186
11062695-2	2000	Meloxicam (preferential COX-2 inhibitor) inhibits the growth of COX-2 positive and COX-1 negative colorectal cancer cells.	Meloxicam	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
11062695-2	2000	Meloxicam (preferential COX-2 inhibitor) inhibits the growth of COX-2 positive and COX-1 negative colorectal cancer cells.	Meloxicam	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-69
10971474-8	2000	The mechanisms which regulate COX-2 mRNA expression were studied using inhibitors of translation (Actinomycin D) and transcription (Cicloheximide).	Dactinomycin	98-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-35
10971474-8	2000	The mechanisms which regulate COX-2 mRNA expression were studied using inhibitors of translation (Actinomycin D) and transcription (Cicloheximide).	Cycloheximide	132-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-35
10971474-13	2000	Dexamethasone and IL-10 abrogated cytokine-induced COX-2 mRNA and protein expression.	Dexamethasone	0-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-56
10996026-1	2000	T614 (3-formylamino-7-methylsulfonylamino-6-phenoxy-4H-1-benzopyran-4-o ne) is a member of the family of methanesulfonanilide non-steroidal anti-inflammatory drugs (mNSAIDs), most of which act as cyclooxygenase (COX)-2 inhibitors.	3-formylamino-7-methylsulfonylamino-6-phenoxy-4h-1-benzopyran-4-o	6-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	196-218
10996026-1	2000	T614 (3-formylamino-7-methylsulfonylamino-6-phenoxy-4H-1-benzopyran-4-o ne) is a member of the family of methanesulfonanilide non-steroidal anti-inflammatory drugs (mNSAIDs), most of which act as cyclooxygenase (COX)-2 inhibitors.	N-Phenylmethanesulfonamide	105-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	196-218
11071120-6	2000	Interestingly, only COX-2 protein, but not COX-1 protein, was induced in 17beta-estradiol treated HUVEC and was also inhibited by staurosporine.	Estradiol	73-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-25
11071120-6	2000	Interestingly, only COX-2 protein, but not COX-1 protein, was induced in 17beta-estradiol treated HUVEC and was also inhibited by staurosporine.	Staurosporine	130-143	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-25
11071120-7	2000	CONCLUSION: Our data showed that 17beta-estradiol increased the release of PGI2 from HUVEC via the induction of COX-2 which was mediated through protein kinase C. The results suggested that COX-2 might have a role in the cardiovascular protective effect of estrogen.	Estradiol	33-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-117
11071120-7	2000	CONCLUSION: Our data showed that 17beta-estradiol increased the release of PGI2 from HUVEC via the induction of COX-2 which was mediated through protein kinase C. The results suggested that COX-2 might have a role in the cardiovascular protective effect of estrogen.	Estradiol	33-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	190-195
10946311-4	2000	Enhancement of TNF-alpha-stimulated PGE2 production in synovial cells was accompanied by increased expression of cyclooxygenase (COX)-2 and cytosolic phospholipase A2 (cPLA2)-alpha.	Dinoprostone	36-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-135
11071120-7	2000	CONCLUSION: Our data showed that 17beta-estradiol increased the release of PGI2 from HUVEC via the induction of COX-2 which was mediated through protein kinase C. The results suggested that COX-2 might have a role in the cardiovascular protective effect of estrogen.	Epoprostenol	75-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-117
11071120-7	2000	CONCLUSION: Our data showed that 17beta-estradiol increased the release of PGI2 from HUVEC via the induction of COX-2 which was mediated through protein kinase C. The results suggested that COX-2 might have a role in the cardiovascular protective effect of estrogen.	Epoprostenol	75-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	190-195
10999846-9	2000	The Cox-2 staining intensity in the fetal ejaculatory ducts during various times of gestation correlated with previously reported testosterone production rates by the fetal testis.	Testosterone	130-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
10999846-11	2000	The distinct cell type-specific expression patterns of Cox-2 in the prostate (smooth muscle) vs. the seminal vesicles and ejaculatory ducts (epithelium) may reflect the different roles of PGs in these tissues.	Phosphatidylglycerols	188-191	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-60
10946311-5	2000	Blockade of COX-2 enzyme activity with the selective inhibitor NS-398 prevented both TNF-alpha-stimulated and sPLA2-IIA-amplified PGE2 production without affecting COX-2 protein induction.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	63-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-17
10946311-5	2000	Blockade of COX-2 enzyme activity with the selective inhibitor NS-398 prevented both TNF-alpha-stimulated and sPLA2-IIA-amplified PGE2 production without affecting COX-2 protein induction.	Dinoprostone	130-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-17
10946311-6	2000	However, both sPLA2-IIA-amplified PGE2 production and enhanced COX-2 expression were blocked by the sPLA2 inhibitor LY311727.	LY 311727	116-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-68
10946311-8	2000	Based on these findings, we propose a model whereby the enhanced expression of sPLA2-IIA by RA synovial cells up-regulates TNF-alpha-mediated PG production via superinduction of COX-2.	Prostaglandins	142-144	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	178-183
10956225-1	2000	A series of heteroaryl modified 1,2-diarylimidazoles has been synthesized and found to be potent and highly selective (1000-9000-fold) inhibitors of the human COX-2.	1,2-diarylimidazoles	32-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	159-164
11005360-3	2000	Two NSAIDs (celecoxib and rofecoxib) with very high specificity for COX-2 and virtually no activity against COX-1 at therapeutic doses have been approved for clinical use.	rofecoxib	26-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-73
10969817-7	2000	Invasion through Matrigel was inhibited by the PLA2 inhibitor 4-bromophenacyl bromide (4-BPB), the general COX inhibitor ibuprofen (IB), and the highly selective COX-2 inhibitor NS398.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	178-183	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	162-167
10937738-2	2000	The results show that some of the 1,3,4-triaryl-3-pyrrolin-2-ones 1 are more potent as COX-2 inhibitors than celecoxib, and that lactam Id has the same selectivity.	1,3,4-triaryl-3-pyrrolin-2-ones	34-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-92
10917546-2	2000	COX is a key enzyme in prostaglandin biosynthesis, and two isoforms of COX, COX-1 and COX-2, have been identified.	Prostaglandins	23-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-91
10942685-1	2000	OBJECTIVES: the preventive effect of acetylsalicylic acid in cardiovascular disease may be due to inhibition of platelet aggregation mediated by COX-1, but may in addition be due to anti-inflammatory effects by inhibition of COX-2.	Aspirin	37-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	225-230
10968618-4	2000	In an effort to unravel the aqueous chemistry of cobalt in the presence of a physiologically relevant ligand, citrate, the first aqueous, soluble, mononuclear complex has been synthesized and isolated from reaction mixtures containing Co(II) and citrate in a 1:2 molar ratio at pH approximately 8.	Cobalt	49-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	235-241
10968618-4	2000	In an effort to unravel the aqueous chemistry of cobalt in the presence of a physiologically relevant ligand, citrate, the first aqueous, soluble, mononuclear complex has been synthesized and isolated from reaction mixtures containing Co(II) and citrate in a 1:2 molar ratio at pH approximately 8.	Citric Acid	110-117	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	235-241
10968618-6	2000	Its X-ray structure consists of a distorted octahedral anion with two citrate ligands fulfilling the coordination requirements of the Co(II) ion.	Citric Acid	70-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-140
10977131-8	2000	The selectivity of S(+) flurbiprofen for inhibition of COX-1 was expressed as the ratio of IC50 for COX-2/COX-1.	Flurbiprofen	20-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-105
10977131-10	2000	After incubation with LPS plus acetylsalicylic acid, positive staining was observed for both COX-1-ir and COX-2-ir.	Aspirin	31-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-111
10977131-12	2000	S(+) flurbiprofen inhibited PGE2 production of untreated tissue homogenates at an IC50 of 8 x 10(-10) M whereas, in the stimulated tissue, IC50 was found to be 3 x 10(-6) M. The selectivity of S(+) flurbiprofen for inhibition of constitutively present COX-1, relative to the inhibition of induced COX-2, was 3,600.	Flurbiprofen	1-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	297-302
10955327-0	2000	Upper gastrointestinal tolerability of celecoxib, a COX-2 specific inhibitor, compared to naproxen and placebo.	Celecoxib	39-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-57
10922992-8	2000	The inhibition of p38 with SB202190 abrogated the osmotic and LPS-induced COX-2 expression and PGI(2) production.	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	27-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
10922992-11	2000	Because COX is the rate-limiting enzyme in prostaglandin synthesis, it is likely that the increase in PGI(2) production is due to, at least in part, the increased COX-2 expression.	Prostaglandins	43-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	163-168
10922992-11	2000	Because COX is the rate-limiting enzyme in prostaglandin synthesis, it is likely that the increase in PGI(2) production is due to, at least in part, the increased COX-2 expression.	Epoprostenol	102-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	163-168
10947155-11	2000	Also, the serine/threonine phosphatase inhibitor okadaic acid augmented Cox-2 and TNFalpha mRNA expression in the LPS-tolerant cells.	Okadaic Acid	49-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
11005360-2	2000	In inflammation, COX-2 is induced, causing synthesis of the prostaglandins in conditions such as osteoarthritis and rheumatoid arthritis.	Prostaglandins	60-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22
11005360-3	2000	Two NSAIDs (celecoxib and rofecoxib) with very high specificity for COX-2 and virtually no activity against COX-1 at therapeutic doses have been approved for clinical use.	Celecoxib	12-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-73
18968050-1	2000	1-Nitroso-2-naphthol, an excellent color-forming chelating agent, combines to Fe(III), Co(II), Ni(II), Cu(II) and so on to form slightly soluble complexes in aqueous solution.	1-nitroso-2-naphthol	0-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-93
18968050-5	2000	It was shown that the sensitivities of Fe(III) and Co(II) in Tween 80 medium were higher than in chloroform, but that of Cu(II) was lower.	Polysorbates	61-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-57
18968050-6	2000	The interfering effects among analytes ions, Fe(III), Co(II), Ni(II) and Cu(II) were more serious than by other ions, but the interfering effects could be removed by adjusting pH or adding the masking agents such as NH(3) or oxalate.	Oxalates	225-232	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-60
10985721-5	2000	In addition, LiR can be used for reaction with a variety of metal complexes (best with NiII, but also with ZnII, CuII, and CoII) and most useful with free base porphyrins.	Metals	60-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-127
10985731-1	2000	The coordination chemistry of cis-3,5-diaminopiperidine and substituted derivatives An efficient and convenient method for the preparation of cis-3,5-diaminopiperidine (dapi) has been established and the coordination chemistry of this ligand with CoII, CoIII, NiII, CuII, ZnII, and CdII has been investigated in the solid state and in aqueous solution.	DAPI	169-173	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	247-251
10985731-4	2000	[Co(dapi)2]3+ was prepared by aerial oxidation of the corresponding CoII precursor.	co(dapi)2	1-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-72
10924071-2	2000	The prostaglandin endoperoxide H synthase isoform 2 (cyclooxygenase-2, COX-2) has been associated with enhanced growth and/or proliferation of several types of cells.	Prostaglandins	4-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-76
10924071-4	2000	In addition, we examined whether PMA affects interleukin-1beta (IL-1beta) stimulation of COX-2 and PGE(2) production.	Tetradecanoylphorbol Acetate	33-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-94
10924071-6	2000	PMA increased COX-2 protein levels 2.	Tetradecanoylphorbol Acetate	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
10924071-8	2000	Inhibition of either p38 kinase or protein kinase C (PKC) prevented PMA-stimulated COX-2.	Tetradecanoylphorbol Acetate	68-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
10924071-9	2000	Inhibition of COX-2 with either indomethacin or NS-398 had no effect on PMA-stimulated [(3)H]leucine incorporation.	Indomethacin	32-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
10924071-13	2000	These findings indicate that: 1) PMA, acting through PKC and p38 kinase, enhances COX-2 expression, but chronic treatment with PMA partially inhibits IL-1beta stimulation of COX-2; and 2) exogenous PGF(2alpha) is involved in neonatal ventricular myocyte growth but endogenous COX-2 products are not.	Tetradecanoylphorbol Acetate	33-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
10945606-7	2000	Detailed methylation mapping using bisulfite genomic sequencing revealed that loss of expression of COX2 mRNA was closely correlated with methylation of a region upstream of exon 1, and expression could be restored by demethylation using the DNA methyltransferase inhibitor 5-aza-deoxycytidine.	Decitabine	274-293	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-104
11009046-5	2000	Etodolac is a relative selective inhibitor of COX-2, while ibuprofen has a higher potency against COX-1 than COX-2.	Etodolac	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
11009046-5	2000	Etodolac is a relative selective inhibitor of COX-2, while ibuprofen has a higher potency against COX-1 than COX-2.	Ibuprofen	59-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-114
10903770-2	2000	In monocytes, cyclooxygenase type 1 (COX-1) activity appears to favor TXA2 production and COX-2 activity appears to favor PGE2 production.	Dinoprostone	122-126	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-95
10903770-8	2000	This pattern was observed irrespective of whether PGH2 was produced by COX-1 or COX-2 or whether it was added directly.	Prostaglandin H2	50-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-85
10903770-9	2000	Furthermore, the inhibition of eicosanoid production by the action of nonsteroidal anti-inflammatory drugs or by the prevention of COX-2 induction with the p38 mitogen-activated protein kinase inhibitor SKF86002 was greater for PGE2 than for TXA2.	Eicosanoids	31-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-136
10903770-9	2000	Furthermore, the inhibition of eicosanoid production by the action of nonsteroidal anti-inflammatory drugs or by the prevention of COX-2 induction with the p38 mitogen-activated protein kinase inhibitor SKF86002 was greater for PGE2 than for TXA2.	Dinoprostone	228-232	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-136
10899936-1	2000	Prostaglandin (PG) formation by the inducible (type 2) cyclooxygenase (COX-2) and reactive oxygen species (ROS) have been proposed to play important roles in cerebrovascular pathological processes.	Prostaglandins	0-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-76
10899936-1	2000	Prostaglandin (PG) formation by the inducible (type 2) cyclooxygenase (COX-2) and reactive oxygen species (ROS) have been proposed to play important roles in cerebrovascular pathological processes.	Prostaglandins	15-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-76
10899936-4	2000	The expression of COX-2 mRNA and protein in cell lysates was up-regulated, and the amount of PGE(2) formed from exogenous arachidonic acid increased following AdCAT: infection in a dose-dependent manner, paralleling the expression of COX-2 protein.	Arachidonic Acid	122-138	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	234-239
10899936-5	2000	The AdCAT:-induced increase in PGE(2) formation was inhibited by NS-398, a selective inhibitor of COX-2 enzymatic activity.	Prostaglandins E	31-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-103
10899936-5	2000	The AdCAT:-induced increase in PGE(2) formation was inhibited by NS-398, a selective inhibitor of COX-2 enzymatic activity.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	65-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-103
10899936-11	2000	Therefore, peroxide may have regulatory effect on COX-2 function in the cerebral microcirculation.	Peroxides	11-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-55
10977130-1	2000	The purpose of this study was to assess the selectivity and potency of the nonsteroidal anti-inflammatory drug (NSAID), flurbiprofen, and its enantiomers in their inhibition of cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2).	Flurbiprofen	120-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	224-229
10977130-3	2000	Incubation with E. coli lipopolysaccharide (LPS) during 24 hr produced prostaglandin E2 (PGE2) by induction of COX-2 in monocytes, suppressing any possible contribution of COX-1 activity by the addition of acetylsalicylic acid.	Dinoprostone	71-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	111-116
10977130-3	2000	Incubation with E. coli lipopolysaccharide (LPS) during 24 hr produced prostaglandin E2 (PGE2) by induction of COX-2 in monocytes, suppressing any possible contribution of COX-1 activity by the addition of acetylsalicylic acid.	Dinoprostone	89-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	111-116
10977130-5	2000	The selectivity for COX-1 vs. COX-2, expressed as the reciprocal ratio of the IC50, was 32 for racemic, 16 for S(+), and 5.3 for R(-) flurbiprofen.	Flurbiprofen	129-146	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-35
10977130-6	2000	Meloxicam in the same assay showed COX-2 selectivity with a ratio of 0.19.	Meloxicam	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40
10985084-4	2000	The compound isolated from this extract, 7-hydroxy-3,4-dihydrocadalin, showed anti-inflammatory effect on the same experimental model (ED50 of 0.9 mumol/ear), as well as on COX-1 and COX-2 catalysed prostaglandin biosynthesis assays, with IC50 values of 22 microM and 526 microM, respectively.	7-hydroxy-3,4-dihydrocadalin	41-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	183-188
10947155-5	2000	Cycloheximide (10 microM) prevented the transcriptional down-regulation of Cox-2 mRNA and to a lesser extent, TNFalpha mRNA, in LPS-tolerant cells.	Cycloheximide	0-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
10947155-6	2000	Transcriptional arrest with actinomycin D stabilized steady-state expression of Cox-2 mRNA in naive and tolerant cells but destabilized TNFalpha mRNA expression in LPS-tolerant cells.	Dactinomycin	28-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-85
10947155-10	2000	However, cycloheximide augmented both Cox-2 and TNFalpha mRNA expression in this group.	Cycloheximide	9-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-43
10956225-2	2000	3-Pyridyl derived COX-2 selective inhibitor (25) exhibited excellent activity in acute (carrageenan induced paw edema, ED(50) = 5.4 mg/kg) and chronic (adjuvant induced arthritis, ED(50) = 0.25 mg/kg) models of inflammation.	Carrageenan	88-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-23
10930278-3	2000	The reaction was applied to the preparation of the COX-2 specific inhibitor 5-chloro-3-(4-methylsulfonyl)phenyl-2-(2-methyl-5-pyridinyl)pyridine (1), as well as a series of analogues.	5-chloro-3-(4-methylsulfonyl)phenyl-2-(2-methyl-5-pyridinyl)pyridine	76-144	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-56
10873632-4	2000	The role of prostaglandins (PGs) produced by COX-2-expressing macrophages in colon carcinogenesis is still unclear.	Prostaglandins	12-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-50
10961400-5	2000	Specifically, oxacorrole 4 binds to Nil(II), Cu(II), and Co(II) with the participation of all heteroatoms in the coordination.	oxacorrole 4	14-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-63
10873632-4	2000	The role of prostaglandins (PGs) produced by COX-2-expressing macrophages in colon carcinogenesis is still unclear.	Prostaglandins	28-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-50
10877734-4	2000	OBJECTIVE: To determine the effect of rofecoxib, a member of the coxib class of drugs and a specific inhibitor of the COX-2 enzyme, on renal function in elderly patients.	rofecoxib	38-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-123
11014111-3	2000	Rofecoxib (Vioxx, Merck Sharp & Dohme) is a potent and selective inhibitor of the COX-2 isoform of cyclooxygenase which is used as a nonsteroidal anti-inflammatory drug (NSAID).	rofecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-91
10893219-4	2000	Maximal IL-8 release was achieved with 10 ng/ml of TGF-beta1 after 16 h of incubation, which was inhibited by the transcription inhibitor actinomycin D and the corticosteroid dexamethasone but was not affected by the nonselective COX inhibitor indomethacin and the selective COX-2 inhibitor NS-398 despite their inhibition on TGF-beta1-induced PGE(2) release.	Dactinomycin	138-151	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	275-280
10903976-8	2000	Small or partial effects at the relevant doses were observed on induction of cyclo-oxygenase (COX) activity or COX-2 protein suggesting that the primary effects were at the level of arachidonate availability.	Arachidonic Acid	182-194	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	111-116
10903976-11	2000	We therefore speculate that the MEK1/ERK and p38 kinase cascades play a role in the functional coupling of arachidonate release to COX-2.	Arachidonic Acid	107-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-136
10907634-0	2000	Is the COX-2 effect on accelerated hematopoiesis mediated by prostaglandin E2?	Dinoprostone	61-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	7-12
11020910-2	2000	BACKGROUND/AIMS: In this study, it was aimed to examine the effect of nimesulide, a selective inhibitor of cox-2 enzyme, to the gastric mucosa and to correlate its effect with aspirin.	nimesulide	70-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-112
11005569-0	2000	Indomethacin-induced apoptosis in esophageal adenocarcinoma cells involves upregulation of Bax and translocation of mitochondrial cytochrome C independent of COX-2 expression.	Indomethacin	0-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	158-163
11005569-7	2000	In Flo-1 cells, which expressed almost undetectable levels of COX-1 and COX-2, and in Seg-1, which expressed significant levels of COX-1 and COX-2, indomethacin caused upregulation of the pro-apoptotic protein Bax.	Indomethacin	148-160	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
12024624-2	2000	Clinical studies thus far have established that the selective COX-2 inhibitors, celecoxib (Celebrex) and rofecoxib (Vioxx) are effective in the treatment of OA and RA, as are conventional NSAIDs.	Celecoxib	80-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
12024624-2	2000	Clinical studies thus far have established that the selective COX-2 inhibitors, celecoxib (Celebrex) and rofecoxib (Vioxx) are effective in the treatment of OA and RA, as are conventional NSAIDs.	Celecoxib	91-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
12024624-2	2000	Clinical studies thus far have established that the selective COX-2 inhibitors, celecoxib (Celebrex) and rofecoxib (Vioxx) are effective in the treatment of OA and RA, as are conventional NSAIDs.	rofecoxib	105-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
12024624-2	2000	Clinical studies thus far have established that the selective COX-2 inhibitors, celecoxib (Celebrex) and rofecoxib (Vioxx) are effective in the treatment of OA and RA, as are conventional NSAIDs.	rofecoxib	116-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
10925968-0	2000	Reduced risk of upper gastrointestinal ulcer complications with celecoxib, a novel COX-2 inhibitor.	Celecoxib	64-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
10925968-1	2000	OBJECTIVE: The aim of this study was to assess the rate of upper gastrointestinal (UGI) ulcer complications (bleeding, perforation, or gastric outlet obstruction) associated with celecoxib, a specific COX-2 inhibitor, compared with the rate associated with nonspecific, nonsteroidal anti-inflammatory drugs (NSAIDs).	Celecoxib	179-188	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	201-206
10953335-1	2000	Cyclooxygenase (COX), also referred to as prostaglandin endoperoxide synthase, is a key enzyme in the conversion of arachidonic acid to prostaglandins and other eicosanoids.	Arachidonic Acid	116-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-19
10953335-1	2000	Cyclooxygenase (COX), also referred to as prostaglandin endoperoxide synthase, is a key enzyme in the conversion of arachidonic acid to prostaglandins and other eicosanoids.	Prostaglandins	136-150	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-19
10953335-1	2000	Cyclooxygenase (COX), also referred to as prostaglandin endoperoxide synthase, is a key enzyme in the conversion of arachidonic acid to prostaglandins and other eicosanoids.	Eicosanoids	161-172	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-19
10953335-10	2000	Furthermore, indomethacin and NS398 were equipotent for growth inhibition and induction of apoptosis, indicating that eicosanoid synthesis via COX-2 is involved in pancreatic cancer cell proliferation and survival.	Indomethacin	13-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	143-148
10953335-10	2000	Furthermore, indomethacin and NS398 were equipotent for growth inhibition and induction of apoptosis, indicating that eicosanoid synthesis via COX-2 is involved in pancreatic cancer cell proliferation and survival.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	30-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	143-148
10953335-10	2000	Furthermore, indomethacin and NS398 were equipotent for growth inhibition and induction of apoptosis, indicating that eicosanoid synthesis via COX-2 is involved in pancreatic cancer cell proliferation and survival.	Eicosanoids	118-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	143-148
10874020-9	2000	The inhibition of mitogenesis and the increased apoptosis produced by the COX-2 inhibitor was associated with decreased PGE(2) production.	Dinoprostone	120-126	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
10874020-10	2000	The inhibition of replication of gall bladder cancer cells and the increase in apoptosis produced by the selective COX-2 inhibitor suggests that the COX enzymes and the prostanoids may play a role in the development of gall bladder cancer and that the COX-2 inhibitors may have a therapeutic role in the prevention of gall bladder neoplasms.	Prostaglandins	169-180	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-120
10861445-2	2000	Reactive intermediates formed during the arachidonic acid cascade, notably by COX-2, which is upregulated in polyps of FAP patients, may promote various stages of the polyp --> adenoma --> carcinoma sequence.	Arachidonic Acid	41-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-83
10857564-1	2000	A new reversed-phase, isocratic LC method was developed for the quantitative determination of COX-2 inhibitor celecoxib in bulk drugs and in pharmaceutical dosages.	Celecoxib	110-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-99
11005569-7	2000	In Flo-1 cells, which expressed almost undetectable levels of COX-1 and COX-2, and in Seg-1, which expressed significant levels of COX-1 and COX-2, indomethacin caused upregulation of the pro-apoptotic protein Bax.	Indomethacin	148-160	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	141-146
10914695-7	2000	However, COX-2 activity is induced by proinflammatory cytokines and produces prostaglandins that mediate the inflammatory response and pain signaling transmission.	Prostaglandins	77-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	9-14
10914695-11	2000	Two medications that predominantly inhibit only COX-2, rofecoxib and celecoxib, are currently available by prescription in the United States.	rofecoxib	55-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-53
10914695-11	2000	Two medications that predominantly inhibit only COX-2, rofecoxib and celecoxib, are currently available by prescription in the United States.	Celecoxib	69-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-53
11014111-3	2000	Rofecoxib (Vioxx, Merck Sharp & Dohme) is a potent and selective inhibitor of the COX-2 isoform of cyclooxygenase which is used as a nonsteroidal anti-inflammatory drug (NSAID).	rofecoxib	11-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-91
11014111-3	2000	Rofecoxib (Vioxx, Merck Sharp & Dohme) is a potent and selective inhibitor of the COX-2 isoform of cyclooxygenase which is used as a nonsteroidal anti-inflammatory drug (NSAID).	Adenosine Monophosphate	31-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-91
18967999-1	2000	A differential pulse anodic stripping voltammetry was developed for the sensitive and selective determination of Co(II) at 2,4,6-tri(3,5-dimethylpyrazoyl)-1,3,5-triazine modified carbon paste electrode in 0.1 mol l(-1) NH(4)Cl solution (pH 4.95).	2,4,6-tri(3,5-dimethylpyrazoyl)-1,3,5-triazine	123-169	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-119
10871971-0	2000	A randomized trial of the efficacy and tolerability of the COX-2 inhibitor rofecoxib vs ibuprofen in patients with osteoarthritis.	rofecoxib	75-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-64
18967999-1	2000	A differential pulse anodic stripping voltammetry was developed for the sensitive and selective determination of Co(II) at 2,4,6-tri(3,5-dimethylpyrazoyl)-1,3,5-triazine modified carbon paste electrode in 0.1 mol l(-1) NH(4)Cl solution (pH 4.95).	Carbon	179-185	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-119
18967999-1	2000	A differential pulse anodic stripping voltammetry was developed for the sensitive and selective determination of Co(II) at 2,4,6-tri(3,5-dimethylpyrazoyl)-1,3,5-triazine modified carbon paste electrode in 0.1 mol l(-1) NH(4)Cl solution (pH 4.95).	(4)cl	221-226	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-119
18967999-5	2000	The current was proportional to the concentration of the Co(II) ion in a range of 1x10(-8)-1x10(-6) mol l(-1) for 3 min accumulation and in the range of 1x10(-9)-1x10(-8) mol l(-1) for 5 min accumulation; most of metal ions do not interfere with the determination.	Metals	213-218	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-63
18967999-6	2000	The developed method was applied to Co(II) determination in potable water.	Water	68-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-42
18968002-1	2000	This paper reports the use of an adsorptive voltammetric technique for the simultaneous detection of Cd(II), Ni(II) and Co(II) using ammonium 2-amino-cyclopente dithiocarboxylate as a selective complexing agent.	ammonium 2-amino-cyclopente dithiocarboxylate	133-178	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-126
10843703-5	2000	This down-regulation of PGE2 formation involved the inhibition of the inducible COX-2 isoform expression both at the transcriptional and translational levels, whereas expression of the constitutive COX-1 isoform was unaltered.	Dinoprostone	24-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-85
10848664-7	2000	In the whole blood assays, the COX-2/COX-1 ratio for meloxicam was 0.2 compared to 0.9 for indomethacin confirming meloxicam"s COX-2 selectivity.	Meloxicam	115-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-36
10848664-7	2000	In the whole blood assays, the COX-2/COX-1 ratio for meloxicam was 0.2 compared to 0.9 for indomethacin confirming meloxicam"s COX-2 selectivity.	Meloxicam	115-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	127-132
10848516-5	2000	Both selective COX-2 inhibitors decreased PGE(2) and 6ketoPGF(1alpha) production in vitro; both inhibitors constricted the isolated ductus in vitro.	Prostaglandins E	42-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-20
10848516-6	2000	The nonselective COX-1/COX-2 inhibitor indomethacin produced a further reduction in PG release and an additional increase in ductus tension in vitro.	Indomethacin	39-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-28
10858308-8	2000	Both inhibitors perturb the d-d transitions of CoCPD in the 500-600 nm region within milliseconds of mixing but only the CoCPD.D-Cys complex displays a strong S --> Co(II) charge-transfer band at 340 nm indicative of a metal-sulfur bond.	D-cysteine	127-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	168-174
10858308-8	2000	Both inhibitors perturb the d-d transitions of CoCPD in the 500-600 nm region within milliseconds of mixing but only the CoCPD.D-Cys complex displays a strong S --> Co(II) charge-transfer band at 340 nm indicative of a metal-sulfur bond.	Metals	222-227	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	168-174
10858308-8	2000	Both inhibitors perturb the d-d transitions of CoCPD in the 500-600 nm region within milliseconds of mixing but only the CoCPD.D-Cys complex displays a strong S --> Co(II) charge-transfer band at 340 nm indicative of a metal-sulfur bond.	Sulfur	228-234	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	168-174
10851109-0	2000	Treatment of acute low back pain with the COX-2-selective anti-inflammatory drug nimesulide: results of a randomized, double-blind comparative trial versus ibuprofen.	nimesulide	81-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47
10851109-16	2000	CONCLUSIONS: The results confirmed that the COX-2-selective inhibitor nimesulide is an effective and well-tolerated agent for use in general practices to treat acute low back pain.	nimesulide	70-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-49
10848664-2	2000	In contrast COX-2, an inducible enzyme, forms prostanoids involved in pain and inflammation.	Prostaglandins	46-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-17
10848664-3	2000	AIM: To compare prostaglandin synthesis inhibition by meloxicam, a selective COX-2 NSAID reported to have better gastric tolerability, with indomethacin and NS-398 in human gastric mucosa and in whole blood assays.	Meloxicam	54-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-82
10848664-7	2000	In the whole blood assays, the COX-2/COX-1 ratio for meloxicam was 0.2 compared to 0.9 for indomethacin confirming meloxicam"s COX-2 selectivity.	Meloxicam	53-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-36
10848516-6	2000	The nonselective COX-1/COX-2 inhibitor indomethacin produced a further reduction in PG release and an additional increase in ductus tension in vitro.	pg	84-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-28
10871971-4	2000	Therefore, we compared the efficacy and safety of the rofecoxib, which specifically inhibits COX-2, with those of the NSAID ibuprofen in patients with OA.	rofecoxib	54-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-98
10868686-6	2000	Bile acids could induce COX-2 expression in six of eight cell lines tested, which was correlated with prostaglandin E2 production, and aspirin could inhibit COX-2 enzymatic activity even after bile acid stimulation but was unable to change the COX-2 protein level in these cell lines.	Bile Acids and Salts	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
10789972-3	2000	The color reactions of Cu(II), Co(II), and Ni(II) with dithiooxamide, were realised on filter paper.	rubeanic acid	55-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-36
10868686-6	2000	Bile acids could induce COX-2 expression in six of eight cell lines tested, which was correlated with prostaglandin E2 production, and aspirin could inhibit COX-2 enzymatic activity even after bile acid stimulation but was unable to change the COX-2 protein level in these cell lines.	Aspirin	135-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	157-162
10868686-6	2000	Bile acids could induce COX-2 expression in six of eight cell lines tested, which was correlated with prostaglandin E2 production, and aspirin could inhibit COX-2 enzymatic activity even after bile acid stimulation but was unable to change the COX-2 protein level in these cell lines.	Dinoprostone	102-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
10868686-6	2000	Bile acids could induce COX-2 expression in six of eight cell lines tested, which was correlated with prostaglandin E2 production, and aspirin could inhibit COX-2 enzymatic activity even after bile acid stimulation but was unable to change the COX-2 protein level in these cell lines.	Aspirin	135-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	157-162
10843735-5	2000	A COX-2 inhibitor and cPLA(2)inhibitor markedly suppressed the IL-1beta-induced delayed PGE(2)generation, while a type IIA sPLA(2)inhibitor failed to affect it.	Prostaglandins E	88-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	2-7
10873107-1	2000	The antitumor effects of the selective cyclooxygenase (COX)-2 inhibitor SC-236 alone and in combination with radiation were investigated using the human glioma cell line U251 grown in monolayer culture and as tumor xenografts.	4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide	72-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-61
10843735-7	2000	These results indicate that IL-1beta-induced delayed PGE(2)generation in these human fibroblasts mainly depends on de novo induction of COX-2 and cPLA(2), irrespective of the constitutive presence of COX-1, and that IFN-gamma and IL-4 inhibit IL-1beta-induced delayed PGE(2)generation by suppressing, predominantly, COX-2 expression.	Prostaglandins E	53-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	136-141
10794682-0	2000	N-[[(5-methyl-3-phenylisoxazol-4-yl)-phenyl]sulfonyl]propanamide, sodium salt, parecoxib sodium: A potent and selective inhibitor of COX-2 for parenteral administration.	parecoxib	0-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	133-138
10882157-7	2000	Two drugs that are claimed to be highly selective or specific in their ability to inhibit COX-2, rofecoxib and celecoxib, are now available on prescription in the US and rofecoxib is available in Europe.	rofecoxib	97-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-95
10882157-7	2000	Two drugs that are claimed to be highly selective or specific in their ability to inhibit COX-2, rofecoxib and celecoxib, are now available on prescription in the US and rofecoxib is available in Europe.	Celecoxib	111-120	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-95
10882157-7	2000	Two drugs that are claimed to be highly selective or specific in their ability to inhibit COX-2, rofecoxib and celecoxib, are now available on prescription in the US and rofecoxib is available in Europe.	rofecoxib	170-179	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-95
10797288-1	2000	Cyclooxygenase (COX)-2 is one of the rate-limiting enzymes in the conversion of arachidonic acid to prostaglandins and other eicosanoids.	Arachidonic Acid	80-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-22
10797288-1	2000	Cyclooxygenase (COX)-2 is one of the rate-limiting enzymes in the conversion of arachidonic acid to prostaglandins and other eicosanoids.	Prostaglandins	100-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-22
10797288-1	2000	Cyclooxygenase (COX)-2 is one of the rate-limiting enzymes in the conversion of arachidonic acid to prostaglandins and other eicosanoids.	Eicosanoids	125-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-22
10797288-6	2000	Transfection with the antisense oligonucleotide suppressed COX-2 protein expression and significantly inhibited cell growth.	Oligonucleotides	32-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-64
10797288-7	2000	The effect of a selective inhibitor of COX-2, NS398, was compared with the effect of the antisense oligonucleotide in order to see whether COX-2 expression and prostaglandins have selective effects on cell growth.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	46-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-44
10868317-1	2000	The objective of this study was to determine the effects of celecoxib, an anti-inflammatory/analgesic agent that primarily inhibits COX-2 and not COX-1 at therapeutic doses, on the steady-state pharmacokinetic profile and hypoprothrombinemic effect of racemic warfarin in healthy volunteers.	Celecoxib	60-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-137
10909271-1	2000	Inhibitory effect of naproxene and its 7-methoxy isomer on constitutive COX-1 and inducible COX-2.	Naproxen	21-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-97
10909271-3	2000	We evaluated the ability of naproxene and its 7-methoxy isomer to abrogate constitutive COX-1 and inducible COX-2 activity in human A549 cells.	Naproxen	28-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-113
10909271-4	2000	Naproxene inhibited COX-1 (IC50 = 3.42 microM) and COX-2 (IC50 = 1.53 microM), whereas the 7-methoxy isomer had no appreciable effect on COX-1 (IC50 >> 100 microM) but also abrogated the activity of COX-2 enzyme (IC50 = 14.42 microM).	Naproxen	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-56
10909271-4	2000	Naproxene inhibited COX-1 (IC50 = 3.42 microM) and COX-2 (IC50 = 1.53 microM), whereas the 7-methoxy isomer had no appreciable effect on COX-1 (IC50 >> 100 microM) but also abrogated the activity of COX-2 enzyme (IC50 = 14.42 microM).	Naproxen	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	205-210
10821716-2	2000	Some compounds, which have a lower alkyl group at the 2-position of the gamma-sultam skeleton, showed potent inhibitory effects on both cyclooxygenase (COX)-2 and 5-lipoxygenase (5-LO), as well as production of interleukin (IL)-1 in in vitro assays.	gamma-sultam	72-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	136-158
10833474-2	2000	We evaluated the effect of cyclooxygenase (COX) inhibitors (NSAIDs) on human colon carcinoma cells (HCA-7) and identified several genes that are regulated after treatment with NS-398, a selective COX-2 inhibitor.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	176-182	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	196-201
12958939-3	2000	As a result, part of the metal ions in metalloenzyme were replaced and the corresponding metalloenzyme derivatives (Co(II)-substituted derivatives of SOD) were produced and the catalytic activity of enzyme were affected.	Metals	25-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-121
10828079-6	2000	In primary keratinocytes transiently transfected with a full-length COX-2 promoter linked to a luciferase reporter gene, we observed enhanced transcription by AA, PGE(2), and the other prostaglandins.	Prostaglandins E	163-166	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-73
10828079-6	2000	In primary keratinocytes transiently transfected with a full-length COX-2 promoter linked to a luciferase reporter gene, we observed enhanced transcription by AA, PGE(2), and the other prostaglandins.	Prostaglandins	185-199	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-73
10828079-7	2000	Forskolin, a known activator of adenylate cyclase, and dibutryl-cAMP, a cAMP analog, induced COX-1 and COX-2 mRNA, suggesting that cAMP is a second messenger for COX expression.	Colforsin	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-108
10828079-7	2000	Forskolin, a known activator of adenylate cyclase, and dibutryl-cAMP, a cAMP analog, induced COX-1 and COX-2 mRNA, suggesting that cAMP is a second messenger for COX expression.	dibutryl-camp	55-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-108
10828079-7	2000	Forskolin, a known activator of adenylate cyclase, and dibutryl-cAMP, a cAMP analog, induced COX-1 and COX-2 mRNA, suggesting that cAMP is a second messenger for COX expression.	Cyclic AMP	64-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-108
10828079-7	2000	Forskolin, a known activator of adenylate cyclase, and dibutryl-cAMP, a cAMP analog, induced COX-1 and COX-2 mRNA, suggesting that cAMP is a second messenger for COX expression.	Cyclic AMP	72-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-108
10828079-8	2000	SQ 22536, an adenylate cyclase inhibitor, inhibited COX-2 mRNA induction by PGE(2) in a dose-dependent manner suggesting that PGE(2)-induced expression may be through one of the cAMP-linked PGE(2) receptors.	Prostaglandins E	76-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-57
10828079-8	2000	SQ 22536, an adenylate cyclase inhibitor, inhibited COX-2 mRNA induction by PGE(2) in a dose-dependent manner suggesting that PGE(2)-induced expression may be through one of the cAMP-linked PGE(2) receptors.	Prostaglandins E	126-129	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-57
10828079-8	2000	SQ 22536, an adenylate cyclase inhibitor, inhibited COX-2 mRNA induction by PGE(2) in a dose-dependent manner suggesting that PGE(2)-induced expression may be through one of the cAMP-linked PGE(2) receptors.	Cyclic AMP	178-182	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-57
10828079-8	2000	SQ 22536, an adenylate cyclase inhibitor, inhibited COX-2 mRNA induction by PGE(2) in a dose-dependent manner suggesting that PGE(2)-induced expression may be through one of the cAMP-linked PGE(2) receptors.	Prostaglandins E	126-129	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-57
10821698-1	2000	Cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) are the enzymes responsible for the biosynthesis of the precursor to the biologically active prostaglandins, prostacyclin, and thromboxane and are the molecular targets for nonsteroidal antiinflammatory drugs (NSAIDs).	Prostaglandins	147-161	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
10821698-1	2000	Cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) are the enzymes responsible for the biosynthesis of the precursor to the biologically active prostaglandins, prostacyclin, and thromboxane and are the molecular targets for nonsteroidal antiinflammatory drugs (NSAIDs).	Epoprostenol	163-175	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
10821698-1	2000	Cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) are the enzymes responsible for the biosynthesis of the precursor to the biologically active prostaglandins, prostacyclin, and thromboxane and are the molecular targets for nonsteroidal antiinflammatory drugs (NSAIDs).	Thromboxanes	181-192	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
10821698-8	2000	The selectivity of SC299 as a COX-2 inhibitor correlates to its relative rates of dissociation from the two COX isoforms.	SC 299	19-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-35
11324434-7	2000	Accordingly, NSAIDs may exhibit anti-carcinogenic property through the inhibition of prostaglandin production by COX-2 expressing interstitial cells.	Prostaglandins	85-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-118
10794682-0	2000	N-[[(5-methyl-3-phenylisoxazol-4-yl)-phenyl]sulfonyl]propanamide, sodium salt, parecoxib sodium: A potent and selective inhibitor of COX-2 for parenteral administration.	sodium salt	66-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	133-138
10794682-0	2000	N-[[(5-methyl-3-phenylisoxazol-4-yl)-phenyl]sulfonyl]propanamide, sodium salt, parecoxib sodium: A potent and selective inhibitor of COX-2 for parenteral administration.	parecoxib	79-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	133-138
10889329-0	2000	The pyrrole moiety as a template for COX-1/COX-2 inhibitors.	Pyrroles	4-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
10780998-8	2000	COX-2 protein was weakly induced by SPNO in basal conditions and in the presence of LPS a synergy for HO-1 and COX-2 protein expression was observed.	spermine nitric oxide complex	36-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
10780998-8	2000	COX-2 protein was weakly induced by SPNO in basal conditions and in the presence of LPS a synergy for HO-1 and COX-2 protein expression was observed.	spermine nitric oxide complex	36-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	111-116
10780998-10	2000	Our results indicate that reactive oxygen species participate in the inductive effect of NO donors or LPS on HO-1 expression, whereas endogenous NO production may play a role in the mechanism of the synergy exhibited by SPNO and LPS on HO-1 and COX-2 expression.	spermine nitric oxide complex	220-224	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	245-250
10780998-13	2000	The selective COX-2 inhibitors SC58125 and NS398 as well as the non-selective COX inhibitor, indomethacin, strongly reduced PGE(2) synthesis and showed a synergy with NO donors in HO-1 and COX-2 induction.	1-((4-methylsulfonyl)phenyl)-3-trifluoromethyl-5-(4-fluorophenyl)pyrazole	31-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
10780998-13	2000	The selective COX-2 inhibitors SC58125 and NS398 as well as the non-selective COX inhibitor, indomethacin, strongly reduced PGE(2) synthesis and showed a synergy with NO donors in HO-1 and COX-2 induction.	1-((4-methylsulfonyl)phenyl)-3-trifluoromethyl-5-(4-fluorophenyl)pyrazole	31-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	189-194
10780998-13	2000	The selective COX-2 inhibitors SC58125 and NS398 as well as the non-selective COX inhibitor, indomethacin, strongly reduced PGE(2) synthesis and showed a synergy with NO donors in HO-1 and COX-2 induction.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	43-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
10780998-13	2000	The selective COX-2 inhibitors SC58125 and NS398 as well as the non-selective COX inhibitor, indomethacin, strongly reduced PGE(2) synthesis and showed a synergy with NO donors in HO-1 and COX-2 induction.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	43-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	189-194
10780998-13	2000	The selective COX-2 inhibitors SC58125 and NS398 as well as the non-selective COX inhibitor, indomethacin, strongly reduced PGE(2) synthesis and showed a synergy with NO donors in HO-1 and COX-2 induction.	Indomethacin	93-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	189-194
10780998-13	2000	The selective COX-2 inhibitors SC58125 and NS398 as well as the non-selective COX inhibitor, indomethacin, strongly reduced PGE(2) synthesis and showed a synergy with NO donors in HO-1 and COX-2 induction.	Dinoprostone	124-130	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
10877012-1	2000	OBJECTIVE: Prostaglandin synthesis is catalyzed by a constitutive cyclo-oxygenase isoform (COX-1) and an inducible isoform (COX-2).	Prostaglandins	11-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	124-129
10877012-2	2000	It is hypothesized that the analgesic and anti-inflammatory effects of nonsteroidal anti-inflammatory drugs (nonspecific COX-1/COX-2 inhibitors) such as ibuprofen principally derive from COX-2 inhibition.	Ibuprofen	153-162	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	127-132
10877012-2	2000	It is hypothesized that the analgesic and anti-inflammatory effects of nonsteroidal anti-inflammatory drugs (nonspecific COX-1/COX-2 inhibitors) such as ibuprofen principally derive from COX-2 inhibition.	Ibuprofen	153-162	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	187-192
10877012-3	2000	The purpose of this study was to evaluate steady-state pharmacokinetics, biochemical selectivity and tolerability of rofecoxib (Vioxx), characterized in vitro as a COX-2 inhibitor.	rofecoxib	117-126	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	164-169
10877012-3	2000	The purpose of this study was to evaluate steady-state pharmacokinetics, biochemical selectivity and tolerability of rofecoxib (Vioxx), characterized in vitro as a COX-2 inhibitor.	rofecoxib	128-133	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	164-169
10877012-8	2000	COX-2 inhibitory activity as assessed by average inhibition of whole blood lipopolysaccharide-stimulated prostaglandin E2 over the 8-h post-dose period on day 14 was 0.3, 67, 96, 92 and 96% for the placebo and the 25-, 100-, 250- and 375-mg treatment groups, respectively.	Dinoprostone	105-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
10877012-11	2000	CONCLUSION: The results indicate that rofecoxib is a potent and specific inhibitor of COX-2 in humans even at doses more than tenfold higher than those associated with efficacy in patients with osteoarthritis.	rofecoxib	38-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-91
11317164-1	2000	Celecoxib is a cyclooxygenase- (COX)-1-sparing inhibitor of COX-2 that is indicated for the treatment of osteoarthritis and rheumatoid arthritis.	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-65
11317165-1	2000	The novel cyclooxygenase- (COX)-2 inhibitor celecoxib is an effective treatment for the signs and symptoms of osteoarthritis and rheumatoid arthritis.	Celecoxib	44-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-33
11317165-4	2000	As celecoxib inhibits COX-2 and spares COX-1 at therapeutic doses, we hypothesized that it may offer an improved renal safety profile in patients at risk for NSAID-induced renal toxicity.	Celecoxib	3-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-27
10815926-2	2000	Our study shows that a cyclooxygenase (COX)-2 inhibitor, nimesulide, can inhibit proliferation of non-small cell lung cancer cell lines in vitro in a dose-dependent manner, in part by inducing apoptosis even at clinically achievable low concentrations.	nimesulide	57-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-45
10889329-3	2000	The determination of the concentration of arachidonic acid metabolites was performed by HPLC for COX-1 and RIA for COX-2.	Arachidonic Acid	42-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-120
10889329-1	2000	Aroyl- and thiophene-substituted pyrrole derivatives have been synthesized as a new class of COX-1/COX-2 inhibitors.	aroyl- and thiophene	0-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-104
10889329-1	2000	Aroyl- and thiophene-substituted pyrrole derivatives have been synthesized as a new class of COX-1/COX-2 inhibitors.	substituted pyrrole	21-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-104
10811000-5	2000	Exposure to GBS caused monocytes to express COX-2 mRNA and protein in both a time- and concentration-dependent manner that correlated with eicosanoid production.	gbs	12-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-49
10811855-5	2000	Both celecoxib, a selective COX-2 inhibitor, and ibuprofen attenuated the pyrexial, but not the chronotropic, response to LPS.	Celecoxib	5-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
11227428-1	2000	Cadmium (along with Fe(II), Co(II), Zn(II), and Pb(II) ions) decreases the rate of oxidation of 3,3",5,5"-tetramethylbenzidine (TMB) with KIO4 conducted either without or with Mn(II) as a catalyst.	3,3',5,5'-tetramethylbenzidine	96-126	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-34
11227428-1	2000	Cadmium (along with Fe(II), Co(II), Zn(II), and Pb(II) ions) decreases the rate of oxidation of 3,3",5,5"-tetramethylbenzidine (TMB) with KIO4 conducted either without or with Mn(II) as a catalyst.	3,3',5,5'-tetramethylbenzidine	128-131	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-34
11227428-1	2000	Cadmium (along with Fe(II), Co(II), Zn(II), and Pb(II) ions) decreases the rate of oxidation of 3,3",5,5"-tetramethylbenzidine (TMB) with KIO4 conducted either without or with Mn(II) as a catalyst.	kio4	138-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-34
11227428-1	2000	Cadmium (along with Fe(II), Co(II), Zn(II), and Pb(II) ions) decreases the rate of oxidation of 3,3",5,5"-tetramethylbenzidine (TMB) with KIO4 conducted either without or with Mn(II) as a catalyst.	Manganese(2+)	176-182	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-34
10811000-5	2000	Exposure to GBS caused monocytes to express COX-2 mRNA and protein in both a time- and concentration-dependent manner that correlated with eicosanoid production.	Eicosanoids	139-149	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-49
10811000-7	2000	Addition of the anti-inflammatory cytokines interleukin (IL)-4 or IL-10 markedly attenuated GBS-induced COX-2 protein accumulation after GBS exposure, as did inhibition of p38 MAPK.	gbs	92-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
10811000-7	2000	Addition of the anti-inflammatory cytokines interleukin (IL)-4 or IL-10 markedly attenuated GBS-induced COX-2 protein accumulation after GBS exposure, as did inhibition of p38 MAPK.	gbs	137-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
10797536-6	2000	The steady-state levels of CO subunit II (CO II; mitochondrial-encoded) and IV (CO IV; nuclear-encoded) mRNAs were up-regulated in response to 5 hr of 20 mM KCl treatment.	Potassium Chloride	157-160	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-40
10811000-8	2000	Our experiments are the first to show that exposure of monocytes to a gram-positive bacterium (GBS) results in induction of functional COX-2, suggesting that eicosanoids may play important roles in the pathogenesis of GBS infections.	gbs	95-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-140
10797536-6	2000	The steady-state levels of CO subunit II (CO II; mitochondrial-encoded) and IV (CO IV; nuclear-encoded) mRNAs were up-regulated in response to 5 hr of 20 mM KCl treatment.	Potassium Chloride	157-160	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47
10797536-7	2000	By using gene-specific probes, the relative rates of synthesis of CO II and IV mRNA were elevated significantly after KCl treatment (P < 0.05).	Potassium Chloride	118-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-71
10811000-8	2000	Our experiments are the first to show that exposure of monocytes to a gram-positive bacterium (GBS) results in induction of functional COX-2, suggesting that eicosanoids may play important roles in the pathogenesis of GBS infections.	Eicosanoids	158-169	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-140
10797536-8	2000	The degradation of CO II and IV mRNAs was monitored by (3)H-uridine pulse-chase labeling, which revealed half-lives of 84 min for CO II mRNA and 50 min for CO IV mRNA.	Uridine	60-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-24
10766797-2	2000	The cyclooxygenase (COX)-2 enzyme is responsible for increased prostaglandin formation in inflammatory states and is the major target of nonsteroidal anti-inflammatory drugs.	Prostaglandins	63-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-26
10797536-8	2000	The degradation of CO II and IV mRNAs was monitored by (3)H-uridine pulse-chase labeling, which revealed half-lives of 84 min for CO II mRNA and 50 min for CO IV mRNA.	Uridine	60-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	130-135
11257482-1	2000	We have investigated the chemiluminescence signal of luminol and hydrogen peroxide in the presence of a transition metal (Co(II), Cu(I), Fe(II), Fe(III)) and of a chelator (EDTA, citric acid) in pH 8.5, 9 and 10 borate buffer solutions.	Luminol	53-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-128
11257482-1	2000	We have investigated the chemiluminescence signal of luminol and hydrogen peroxide in the presence of a transition metal (Co(II), Cu(I), Fe(II), Fe(III)) and of a chelator (EDTA, citric acid) in pH 8.5, 9 and 10 borate buffer solutions.	Metals	115-120	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-128
10852985-1	2000	OBJECTIVE: To investigate the regulation of whole-blood cyclooxygenase-1 and -2 (COX-2 and COX-1) activities by methotrexate (MTX) in rheumatoid arthritis (RA) patients.	Methotrexate	112-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-86
10852985-9	2000	Assays performed with blood from RA/MTX patients showed preferential inhibition of COX-2 activity (PGE(2) = 10.11 +/- 2.42 ng/ml) when compared with blood of normal donors (PGE(2) = 37.7 +/- 4.36 ng/ml; P = 0.001).	Prostaglandins E	99-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
12526463-0	2000	Kinetics of manganese(III) acetate in acetic acid: generation of Mn(III) with Co(III), Ce(IV), and dibromide radicals; reactions of Mn(III) with Mn(II), Co(II), hydrogen bromide, and alkali bromides.	Acetic Acid	38-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	153-159
10747776-3	2000	The first coordination sphere of Co(II) in Co(II)BLM has been investigated in the present study through the use of NMR and molecular dynamics calculations.	Cobalt(2+)	43-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-39
10747776-8	2000	The analysis of the structures previously derived for HOO-Co(III)-bleomycin and HOO-Co(III)-pepleomycin led us to propose the six-coordinate structure with only endogenous ligands, as the one held in solution by the Co(II) derivative of bleomycin.	hoo-co(iii)-	54-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	216-222
10747776-8	2000	The analysis of the structures previously derived for HOO-Co(III)-bleomycin and HOO-Co(III)-pepleomycin led us to propose the six-coordinate structure with only endogenous ligands, as the one held in solution by the Co(II) derivative of bleomycin.	Bleomycin	66-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	216-222
10747776-8	2000	The analysis of the structures previously derived for HOO-Co(III)-bleomycin and HOO-Co(III)-pepleomycin led us to propose the six-coordinate structure with only endogenous ligands, as the one held in solution by the Co(II) derivative of bleomycin.	hoo-co(iii)-pepleomycin	80-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	216-222
10747776-8	2000	The analysis of the structures previously derived for HOO-Co(III)-bleomycin and HOO-Co(III)-pepleomycin led us to propose the six-coordinate structure with only endogenous ligands, as the one held in solution by the Co(II) derivative of bleomycin.	Bleomycin	237-246	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	216-222
18967894-1	2000	The fluorescence intensities of the reaction systems of Co(II) with two new 8-sulfonamidoquinoline derivatives, 5-(4-Chlorophenylazo)-8-(benzenesulfonamido)-quinoline (CPBSQ), which was firstly synthesized and characterized, and 5-(3-fluo-4-chlorophenylazo)-8-(benzenesulfonamido)quinoline (FCPBSQ), could be enhanced by H(2)O(2).	quinoline-8-sulfonamide	76-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-62
18967894-1	2000	The fluorescence intensities of the reaction systems of Co(II) with two new 8-sulfonamidoquinoline derivatives, 5-(4-Chlorophenylazo)-8-(benzenesulfonamido)-quinoline (CPBSQ), which was firstly synthesized and characterized, and 5-(3-fluo-4-chlorophenylazo)-8-(benzenesulfonamido)quinoline (FCPBSQ), could be enhanced by H(2)O(2).	5-(4-chlorophenylazo)-8-(benzenesulfonamido)-quinoline	112-166	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-62
18967894-1	2000	The fluorescence intensities of the reaction systems of Co(II) with two new 8-sulfonamidoquinoline derivatives, 5-(4-Chlorophenylazo)-8-(benzenesulfonamido)-quinoline (CPBSQ), which was firstly synthesized and characterized, and 5-(3-fluo-4-chlorophenylazo)-8-(benzenesulfonamido)quinoline (FCPBSQ), could be enhanced by H(2)O(2).	cpbsq	168-173	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-62
18967894-1	2000	The fluorescence intensities of the reaction systems of Co(II) with two new 8-sulfonamidoquinoline derivatives, 5-(4-Chlorophenylazo)-8-(benzenesulfonamido)-quinoline (CPBSQ), which was firstly synthesized and characterized, and 5-(3-fluo-4-chlorophenylazo)-8-(benzenesulfonamido)quinoline (FCPBSQ), could be enhanced by H(2)O(2).	5-(3-fluo-4-chlorophenylazo)-8-(benzenesulfonamido)quinoline	229-289	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-62
12526463-6	2000	Oxidation of Co(II) by HBr2.	hbr2	23-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-19
18967894-1	2000	The fluorescence intensities of the reaction systems of Co(II) with two new 8-sulfonamidoquinoline derivatives, 5-(4-Chlorophenylazo)-8-(benzenesulfonamido)-quinoline (CPBSQ), which was firstly synthesized and characterized, and 5-(3-fluo-4-chlorophenylazo)-8-(benzenesulfonamido)quinoline (FCPBSQ), could be enhanced by H(2)O(2).	fcpbsq	291-297	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-62
18967894-1	2000	The fluorescence intensities of the reaction systems of Co(II) with two new 8-sulfonamidoquinoline derivatives, 5-(4-Chlorophenylazo)-8-(benzenesulfonamido)-quinoline (CPBSQ), which was firstly synthesized and characterized, and 5-(3-fluo-4-chlorophenylazo)-8-(benzenesulfonamido)quinoline (FCPBSQ), could be enhanced by H(2)O(2).	Hydrogen Peroxide	321-329	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-62
18967894-3	2000	CPBSQ and FCPBSQ reacted with Co(II) in the presence of H(2)O(2) and in the basic medium forming a chelate, which exhibited an intensive fluorescence in ultraviolet region.	cpbsq	0-5	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-36
18967894-3	2000	CPBSQ and FCPBSQ reacted with Co(II) in the presence of H(2)O(2) and in the basic medium forming a chelate, which exhibited an intensive fluorescence in ultraviolet region.	fcpbsq	10-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-36
10744623-1	2000	The cyclooxygenases (COX)-1 and COX-2 are key enzymes in the conversion of arachidonic acid to prostaglandins and other eicosanoids.	Arachidonic Acid	75-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-37
18967894-3	2000	CPBSQ and FCPBSQ reacted with Co(II) in the presence of H(2)O(2) and in the basic medium forming a chelate, which exhibited an intensive fluorescence in ultraviolet region.	Hydrogen Peroxide	56-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-36
18967894-4	2000	The fluorescence intensities were proportional to the concentration of Co(II) over the range of 0.1-100 and 0.5-200 mug/l with the detection limits of 0.05 and 0.10 mug/l for the CPBSQ and FCPBSQ systems, respectively.	cpbsq	179-184	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-77
18967894-4	2000	The fluorescence intensities were proportional to the concentration of Co(II) over the range of 0.1-100 and 0.5-200 mug/l with the detection limits of 0.05 and 0.10 mug/l for the CPBSQ and FCPBSQ systems, respectively.	fcpbsq	189-195	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-77
10751330-8	2000	Thus the coordinate expression of sPLA(2) and COX-2 may be responsible for the increased prostaglandin synthesis in activated keratinocytes during wound repair.	Prostaglandins	89-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
10804043-1	2000	UNLABELLED: Celecoxib is a cyclo-oxygenase (COX) inhibitor that exhibits relative in vitro and ex vivo selectivity for COX-2 over COX-1.	Celecoxib	12-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-124
10744623-1	2000	The cyclooxygenases (COX)-1 and COX-2 are key enzymes in the conversion of arachidonic acid to prostaglandins and other eicosanoids.	Prostaglandins	95-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-37
10804043-15	2000	CONCLUSIONS: Celecoxib is the first COX-2 specific inhibitor approved for use in osteoarthritis and rheumatoid arthritis.	Celecoxib	13-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-41
10744623-1	2000	The cyclooxygenases (COX)-1 and COX-2 are key enzymes in the conversion of arachidonic acid to prostaglandins and other eicosanoids.	Eicosanoids	120-131	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-37
10819461-13	2000	The reduction from Co(III) to Co(II) produces the most significant structural changes: the cobalt coordination number decreases from six to five, and the edge position shifts by 2.4 +/- 0.3 eV.	Cobalt	91-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-36
10780769-10	2000	The COX 2:COX 1 selectivity ratio (COX 2 IC50/COX I IC50) was <0.0001 for nimesulide, 0.001 for NS398, 0.03 for flurbiprofen and 1.9 for indomethacin.	Indomethacin	140-152	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40
10858012-6	2000	The inhibition of the induced COX enzyme activity by the selective COX-2 inhibitor NS-398 demonstrated the presence of COX-2 pharmacologically.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	83-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-72
10858012-6	2000	The inhibition of the induced COX enzyme activity by the selective COX-2 inhibitor NS-398 demonstrated the presence of COX-2 pharmacologically.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	83-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-124
10780769-10	2000	The COX 2:COX 1 selectivity ratio (COX 2 IC50/COX I IC50) was <0.0001 for nimesulide, 0.001 for NS398, 0.03 for flurbiprofen and 1.9 for indomethacin.	nimesulide	77-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
10780769-10	2000	The COX 2:COX 1 selectivity ratio (COX 2 IC50/COX I IC50) was <0.0001 for nimesulide, 0.001 for NS398, 0.03 for flurbiprofen and 1.9 for indomethacin.	nimesulide	77-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40
10780769-10	2000	The COX 2:COX 1 selectivity ratio (COX 2 IC50/COX I IC50) was <0.0001 for nimesulide, 0.001 for NS398, 0.03 for flurbiprofen and 1.9 for indomethacin.	Flurbiprofen	115-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
10780769-10	2000	The COX 2:COX 1 selectivity ratio (COX 2 IC50/COX I IC50) was <0.0001 for nimesulide, 0.001 for NS398, 0.03 for flurbiprofen and 1.9 for indomethacin.	Flurbiprofen	115-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40
10780769-10	2000	The COX 2:COX 1 selectivity ratio (COX 2 IC50/COX I IC50) was <0.0001 for nimesulide, 0.001 for NS398, 0.03 for flurbiprofen and 1.9 for indomethacin.	Indomethacin	140-152	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
10699967-9	2000	We also showed the expression of cyclooxygenase (COX)-2 and its partial involvement using a potent selective COX-2 inhibitor, L-745337.	L 745337	126-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-55
10699967-9	2000	We also showed the expression of cyclooxygenase (COX)-2 and its partial involvement using a potent selective COX-2 inhibitor, L-745337.	L 745337	126-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-114
10734173-7	2000	Experiments with purified COX-1 and COX-2 also showed 9-fold increase of 3-nitrotyrosine levels, which correlated with decreased (93-98%) production of prostaglandin H(2) when ONOO(-) (50 microM) was added 1 min before arachidonic acid.	3-nitrotyrosine	73-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-41
10734173-7	2000	Experiments with purified COX-1 and COX-2 also showed 9-fold increase of 3-nitrotyrosine levels, which correlated with decreased (93-98%) production of prostaglandin H(2) when ONOO(-) (50 microM) was added 1 min before arachidonic acid.	Prostaglandins H	152-167	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-41
10734173-7	2000	Experiments with purified COX-1 and COX-2 also showed 9-fold increase of 3-nitrotyrosine levels, which correlated with decreased (93-98%) production of prostaglandin H(2) when ONOO(-) (50 microM) was added 1 min before arachidonic acid.	onoo(-)	176-183	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-41
10734173-7	2000	Experiments with purified COX-1 and COX-2 also showed 9-fold increase of 3-nitrotyrosine levels, which correlated with decreased (93-98%) production of prostaglandin H(2) when ONOO(-) (50 microM) was added 1 min before arachidonic acid.	Arachidonic Acid	219-235	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-41
11193500-6	2000	COX-2 has been focused as a key enzyme to regulate PGE2 synthesis and plays an important role in inflammation, because COX-2 was induced in many types of cells by the stimulation of inflammatory cytokines such as interleukin-1 beta (IL-1 beta) and tumor necrosis factor alpha (TNF alpha).	Dinoprostone	51-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
10785540-3	2000	These involve mediation by various lipoxygenases and COX-2 and lead to ethanolamide analogs of the prostaglandins and HETES.	ethanolamide	71-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-58
11193500-6	2000	COX-2 has been focused as a key enzyme to regulate PGE2 synthesis and plays an important role in inflammation, because COX-2 was induced in many types of cells by the stimulation of inflammatory cytokines such as interleukin-1 beta (IL-1 beta) and tumor necrosis factor alpha (TNF alpha).	Dinoprostone	51-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-124
11193500-11	2000	The disc-derived cells also produced much PGE2 by stimulating of inflammatory cytokines at the same time and this PGE2 production was distinctly suppressed by a selective inhibitor of COX-2, 6-methoxy-2-naphtyl acetic acids (6MNA).	Dinoprostone	114-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	184-189
11193500-11	2000	The disc-derived cells also produced much PGE2 by stimulating of inflammatory cytokines at the same time and this PGE2 production was distinctly suppressed by a selective inhibitor of COX-2, 6-methoxy-2-naphtyl acetic acids (6MNA).	6-methoxy-2-naphtyl acetic acids	191-223	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	184-189
11193500-11	2000	The disc-derived cells also produced much PGE2 by stimulating of inflammatory cytokines at the same time and this PGE2 production was distinctly suppressed by a selective inhibitor of COX-2, 6-methoxy-2-naphtyl acetic acids (6MNA).	6mna	225-229	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	184-189
11193500-12	2000	These results suggest that COX-2 and inflammatory cytokines might play a causative role in the radiculopathy of LDH through upregulating PGE2 synthesis.	Dinoprostone	137-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-32
10763850-1	2000	HN-56249 (3-(2,4-dichlorothiophenoxy)-4-methylsulfonylamino-benzenesu lfonamide), a highly selective cyclooxygenase (COX)-2 inhibitor, is the prototype of a novel series of COX inhibitors comprising bicyclic arylethersulfonamides; of this series HN-56249 is the most potent and selective human COX-2 inhibitor.	SCHEMBL4575696	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-123
10763850-1	2000	HN-56249 (3-(2,4-dichlorothiophenoxy)-4-methylsulfonylamino-benzenesu lfonamide), a highly selective cyclooxygenase (COX)-2 inhibitor, is the prototype of a novel series of COX inhibitors comprising bicyclic arylethersulfonamides; of this series HN-56249 is the most potent and selective human COX-2 inhibitor.	SCHEMBL4575696	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	294-299
10763850-1	2000	HN-56249 (3-(2,4-dichlorothiophenoxy)-4-methylsulfonylamino-benzenesu lfonamide), a highly selective cyclooxygenase (COX)-2 inhibitor, is the prototype of a novel series of COX inhibitors comprising bicyclic arylethersulfonamides; of this series HN-56249 is the most potent and selective human COX-2 inhibitor.	3-(2,4-dichlorothiophenoxy)	10-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-123
10763850-1	2000	HN-56249 (3-(2,4-dichlorothiophenoxy)-4-methylsulfonylamino-benzenesu lfonamide), a highly selective cyclooxygenase (COX)-2 inhibitor, is the prototype of a novel series of COX inhibitors comprising bicyclic arylethersulfonamides; of this series HN-56249 is the most potent and selective human COX-2 inhibitor.	3-(2,4-dichlorothiophenoxy)	10-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	294-299
10763850-1	2000	HN-56249 (3-(2,4-dichlorothiophenoxy)-4-methylsulfonylamino-benzenesu lfonamide), a highly selective cyclooxygenase (COX)-2 inhibitor, is the prototype of a novel series of COX inhibitors comprising bicyclic arylethersulfonamides; of this series HN-56249 is the most potent and selective human COX-2 inhibitor.	-methylsulfonylamino-benzenesu lfonamide	39-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-123
10763850-3	2000	In LPS-stimulated monocytic cells the release of prostaglandin (PG) F1alpha as a measure of COX-2 was markedly inhibited (IC50 0.027+/-0.001 microM).	prostaglandin F1	49-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-97
10763850-8	2000	HN-56249 surpassed the COX-2 selectivities of the COX-2 selective inhibitors 3-cyclohexyloxy-4-methylsulfonylamino-nitrobenzene (NS-398) and 6-(2,4-difluorophenoxy)-5-methyl-sulfonylamino-1-indanone (flosulide) in the intact cell assays by eight- and threefold, respectively, and in the whole blood assays by approximately 40-fold.	3-cyclohexyloxy-4-methylsulfonylamino-nitrobenzene	77-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-28
10763850-8	2000	HN-56249 surpassed the COX-2 selectivities of the COX-2 selective inhibitors 3-cyclohexyloxy-4-methylsulfonylamino-nitrobenzene (NS-398) and 6-(2,4-difluorophenoxy)-5-methyl-sulfonylamino-1-indanone (flosulide) in the intact cell assays by eight- and threefold, respectively, and in the whole blood assays by approximately 40-fold.	3-cyclohexyloxy-4-methylsulfonylamino-nitrobenzene	77-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-55
10763850-8	2000	HN-56249 surpassed the COX-2 selectivities of the COX-2 selective inhibitors 3-cyclohexyloxy-4-methylsulfonylamino-nitrobenzene (NS-398) and 6-(2,4-difluorophenoxy)-5-methyl-sulfonylamino-1-indanone (flosulide) in the intact cell assays by eight- and threefold, respectively, and in the whole blood assays by approximately 40-fold.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	129-135	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-55
10763850-8	2000	HN-56249 surpassed the COX-2 selectivities of the COX-2 selective inhibitors 3-cyclohexyloxy-4-methylsulfonylamino-nitrobenzene (NS-398) and 6-(2,4-difluorophenoxy)-5-methyl-sulfonylamino-1-indanone (flosulide) in the intact cell assays by eight- and threefold, respectively, and in the whole blood assays by approximately 40-fold.	flosulide	141-198	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-28
10763850-8	2000	HN-56249 surpassed the COX-2 selectivities of the COX-2 selective inhibitors 3-cyclohexyloxy-4-methylsulfonylamino-nitrobenzene (NS-398) and 6-(2,4-difluorophenoxy)-5-methyl-sulfonylamino-1-indanone (flosulide) in the intact cell assays by eight- and threefold, respectively, and in the whole blood assays by approximately 40-fold.	flosulide	141-198	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-55
10763850-8	2000	HN-56249 surpassed the COX-2 selectivities of the COX-2 selective inhibitors 3-cyclohexyloxy-4-methylsulfonylamino-nitrobenzene (NS-398) and 6-(2,4-difluorophenoxy)-5-methyl-sulfonylamino-1-indanone (flosulide) in the intact cell assays by eight- and threefold, respectively, and in the whole blood assays by approximately 40-fold.	flosulide	200-209	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-55
10763850-13	2000	Similar effects were observed with other COX-2-selective arylethersulfonamides.	arylethersulfonamides	57-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-46
10763850-14	2000	In contrast, non-COX-2-selective arylethersulfonamides, including a highly selective COX-1 inhibitor, inhibited human and murine COX-2 approximately equipotently.	arylethersulfonamides	33-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22
10785540-3	2000	These involve mediation by various lipoxygenases and COX-2 and lead to ethanolamide analogs of the prostaglandins and HETES.	Prostaglandins	99-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-58
10715145-0	2000	4-[5-Methyl-3-phenylisoxazol-4-yl]- benzenesulfonamide, valdecoxib: a potent and selective inhibitor of COX-2.	valdecoxib	56-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
10741562-2	2000	The 1,3-diaryl substitution pattern of the pyrazole ring in 1 differentiates these compounds from most of the known selective COX-2 inhibitors that contain two aryl rings at the adjacent positions on a heterocyclic or a phenyl ring.	pyrazole	43-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-131
10715145-0	2000	4-[5-Methyl-3-phenylisoxazol-4-yl]- benzenesulfonamide, valdecoxib: a potent and selective inhibitor of COX-2.	valdecoxib	0-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
10694510-1	2000	This study investigated the effects of shear stress on gene expression of prostacyclin synthesis-related enzymes cyclooxygenases (COX-1 and COX-2), prostacyclin synthase (PGS), and thromboxane synthase (TXS) and their metabolites prostaglandin (PGI(2)) and thromboxane A(2) (TXA(2)) in endothelium of intact conduit vessels.	Epoprostenol	74-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-145
10728691-4	2000	The contribution of COX-2 to human tumor growth was indicated by the ability of celecoxib, an agent that inhibits the COX-2 enzyme, to suppress growth of lung and colon tumors implanted into recipient mice.	Celecoxib	80-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-25
10728691-4	2000	The contribution of COX-2 to human tumor growth was indicated by the ability of celecoxib, an agent that inhibits the COX-2 enzyme, to suppress growth of lung and colon tumors implanted into recipient mice.	Celecoxib	80-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-123
10728691-7	2000	These and other data indicate that COX-2 and COX-2-derived prostaglandins may play a major role in development of cancer through numerous biochemical mechanisms, including stimulation of tumor cell growth and neovascularization.	Prostaglandins	59-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-50
10767759-6	2000	Also, certain Co(II) and Fe(II) ion pair complexes undergo oxidation reactions in which species such as dioxygen and nitric oxide from the counterions ClO4- and NO3- are transferred to the Co(II) and Fe(II) complexes, showing the inherent affinity of these metals for these molecules.	punky blue	161-164	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	189-195
10702199-8	2000	In response to pulses of acid or bile salts in an ex vivo organ culture system, COX-2 expression increased significantly in BE tissues, and this effect was attenuated by the selective COX-2 inhibitor NS-398.	Bile Acids and Salts	33-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-85
10702199-8	2000	In response to pulses of acid or bile salts in an ex vivo organ culture system, COX-2 expression increased significantly in BE tissues, and this effect was attenuated by the selective COX-2 inhibitor NS-398.	Bile Acids and Salts	33-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	184-189
10702199-8	2000	In response to pulses of acid or bile salts in an ex vivo organ culture system, COX-2 expression increased significantly in BE tissues, and this effect was attenuated by the selective COX-2 inhibitor NS-398.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	200-206	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-85
10702199-8	2000	In response to pulses of acid or bile salts in an ex vivo organ culture system, COX-2 expression increased significantly in BE tissues, and this effect was attenuated by the selective COX-2 inhibitor NS-398.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	200-206	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	184-189
10702199-10	2000	COX-2 is regulated ex vivo by exposure to acid or bile salts.	Bile Acids and Salts	50-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
10767759-6	2000	Also, certain Co(II) and Fe(II) ion pair complexes undergo oxidation reactions in which species such as dioxygen and nitric oxide from the counterions ClO4- and NO3- are transferred to the Co(II) and Fe(II) complexes, showing the inherent affinity of these metals for these molecules.	ammonium ferrous sulfate	25-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	189-195
10767759-6	2000	Also, certain Co(II) and Fe(II) ion pair complexes undergo oxidation reactions in which species such as dioxygen and nitric oxide from the counterions ClO4- and NO3- are transferred to the Co(II) and Fe(II) complexes, showing the inherent affinity of these metals for these molecules.	Oxygen	104-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-20
10767759-6	2000	Also, certain Co(II) and Fe(II) ion pair complexes undergo oxidation reactions in which species such as dioxygen and nitric oxide from the counterions ClO4- and NO3- are transferred to the Co(II) and Fe(II) complexes, showing the inherent affinity of these metals for these molecules.	Oxygen	104-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	189-195
10767759-6	2000	Also, certain Co(II) and Fe(II) ion pair complexes undergo oxidation reactions in which species such as dioxygen and nitric oxide from the counterions ClO4- and NO3- are transferred to the Co(II) and Fe(II) complexes, showing the inherent affinity of these metals for these molecules.	Nitric Oxide	117-129	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-20
10767759-6	2000	Also, certain Co(II) and Fe(II) ion pair complexes undergo oxidation reactions in which species such as dioxygen and nitric oxide from the counterions ClO4- and NO3- are transferred to the Co(II) and Fe(II) complexes, showing the inherent affinity of these metals for these molecules.	ammonium ferrous sulfate	200-206	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-20
10767759-6	2000	Also, certain Co(II) and Fe(II) ion pair complexes undergo oxidation reactions in which species such as dioxygen and nitric oxide from the counterions ClO4- and NO3- are transferred to the Co(II) and Fe(II) complexes, showing the inherent affinity of these metals for these molecules.	Nitric Oxide	117-129	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	189-195
10767759-6	2000	Also, certain Co(II) and Fe(II) ion pair complexes undergo oxidation reactions in which species such as dioxygen and nitric oxide from the counterions ClO4- and NO3- are transferred to the Co(II) and Fe(II) complexes, showing the inherent affinity of these metals for these molecules.	perchlorate	151-155	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-20
10814343-1	2000	[reaction: see text] Reactions of chalcones 3a-f with bis(1H-1,2,4-triazolyl) sulfoxide 4 formed the thiazolo[3,2-b]1,2,4-triazoles 5a-f, which resemble closely some previously prepared COX-2 inhibitors.	Chalcones	34-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	186-191
10767759-6	2000	Also, certain Co(II) and Fe(II) ion pair complexes undergo oxidation reactions in which species such as dioxygen and nitric oxide from the counterions ClO4- and NO3- are transferred to the Co(II) and Fe(II) complexes, showing the inherent affinity of these metals for these molecules.	perchlorate	151-155	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	189-195
10767759-6	2000	Also, certain Co(II) and Fe(II) ion pair complexes undergo oxidation reactions in which species such as dioxygen and nitric oxide from the counterions ClO4- and NO3- are transferred to the Co(II) and Fe(II) complexes, showing the inherent affinity of these metals for these molecules.	punky blue	161-164	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-20
10679307-0	2000	Induction of COX-2 expression by nitric oxide in rheumatoid synovial cells.	Nitric Oxide	33-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
10679307-3	2000	In this study, we evaluated the contribution of nitric oxide (NO) to COX-2 expression in rheumatoid synovial cells.	Nitric Oxide	48-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-74
10679307-6	2000	Dexamethasone at therapeutic concentrations markedly inhibited this NO-mediated COX-2 expression in synovial cells.	Dexamethasone	0-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-85
10814343-1	2000	[reaction: see text] Reactions of chalcones 3a-f with bis(1H-1,2,4-triazolyl) sulfoxide 4 formed the thiazolo[3,2-b]1,2,4-triazoles 5a-f, which resemble closely some previously prepared COX-2 inhibitors.	bis(1h-1,2,4-triazolyl) sulfoxide	54-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	186-191
10814343-1	2000	[reaction: see text] Reactions of chalcones 3a-f with bis(1H-1,2,4-triazolyl) sulfoxide 4 formed the thiazolo[3,2-b]1,2,4-triazoles 5a-f, which resemble closely some previously prepared COX-2 inhibitors.	thiazolo[3,2-b]1,2,4-triazoles	101-131	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	186-191
10671506-6	2000	To understand the changes that lead to 15R-HETE synthesis in aspirin-treated COX-2, we employed pro-R- and pro-S-labeled [13-(3)H]arachidonic acids to investigate the selectivity of the initial hydrogen abstraction.	Aspirin	61-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-82
10671506-7	2000	Remarkably, aspirin-treated COX-2 formed 15R-HETE with removal of the pro-S hydrogen at C-13 (3-9% retention of pro-S tritium label), the same stereoselectivity as in the formation of prostaglandins by native cyclooxygenase.	Aspirin	12-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
10671506-7	2000	Remarkably, aspirin-treated COX-2 formed 15R-HETE with removal of the pro-S hydrogen at C-13 (3-9% retention of pro-S tritium label), the same stereoselectivity as in the formation of prostaglandins by native cyclooxygenase.	Proline	70-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
10671506-7	2000	Remarkably, aspirin-treated COX-2 formed 15R-HETE with removal of the pro-S hydrogen at C-13 (3-9% retention of pro-S tritium label), the same stereoselectivity as in the formation of prostaglandins by native cyclooxygenase.	Hydrogen	76-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
10671506-7	2000	Remarkably, aspirin-treated COX-2 formed 15R-HETE with removal of the pro-S hydrogen at C-13 (3-9% retention of pro-S tritium label), the same stereoselectivity as in the formation of prostaglandins by native cyclooxygenase.	Tritium	118-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
10671506-7	2000	Remarkably, aspirin-treated COX-2 formed 15R-HETE with removal of the pro-S hydrogen at C-13 (3-9% retention of pro-S tritium label), the same stereoselectivity as in the formation of prostaglandins by native cyclooxygenase.	Prostaglandins	184-198	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
10814343-1	2000	[reaction: see text] Reactions of chalcones 3a-f with bis(1H-1,2,4-triazolyl) sulfoxide 4 formed the thiazolo[3,2-b]1,2,4-triazoles 5a-f, which resemble closely some previously prepared COX-2 inhibitors.	Fluorine	46-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	186-191
10706474-6	2000	Irradiation with Ga-Al-As diode low-level laser significantly inhibited PGE2 production in a dose-dependent manner, which led to a reduction of COX-2 mRNA levels.	ga-al	17-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	144-149
10666314-5	2000	Under these conditions, mRNA and protein levels of the inducible form of cyclooxygenase (COX-2) were upregulated together with its product, PGE(2), a proinflammatory prostaglandin.	Prostaglandins E	140-143	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-94
10666314-5	2000	Under these conditions, mRNA and protein levels of the inducible form of cyclooxygenase (COX-2) were upregulated together with its product, PGE(2), a proinflammatory prostaglandin.	Prostaglandins	166-179	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-94
10701410-5	2000	BEFORE PRESCRIBING: COX-2 may have an ambivalent functionality in the brain since the basal production of prostaglandins through COX-2 may participate in neuronal homeostasis whereas the expression of COX-2 is associated with brain development.	Prostaglandins	106-120	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-25
10701410-5	2000	BEFORE PRESCRIBING: COX-2 may have an ambivalent functionality in the brain since the basal production of prostaglandins through COX-2 may participate in neuronal homeostasis whereas the expression of COX-2 is associated with brain development.	Prostaglandins	106-120	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-134
10701410-5	2000	BEFORE PRESCRIBING: COX-2 may have an ambivalent functionality in the brain since the basal production of prostaglandins through COX-2 may participate in neuronal homeostasis whereas the expression of COX-2 is associated with brain development.	Prostaglandins	106-120	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-134
10701410-8	2000	CURRENT TRIALS: Clinical studies focusing on both the prevention and the slowing down of early AD are under way with two recently launched selective COX-2 inhibitors, celecoxib and rofecoxib.	Celecoxib	167-176	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	149-154
10701410-8	2000	CURRENT TRIALS: Clinical studies focusing on both the prevention and the slowing down of early AD are under way with two recently launched selective COX-2 inhibitors, celecoxib and rofecoxib.	rofecoxib	181-190	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	149-154
10718662-1	2000	A simple, HPLC method was developed to estimate meloxicam (COX-2 inhibitor) using piroxicam as the internal standard.	Meloxicam	48-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-64
10718662-1	2000	A simple, HPLC method was developed to estimate meloxicam (COX-2 inhibitor) using piroxicam as the internal standard.	Piroxicam	82-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-64
10666384-5	2000	Forty of 52 (77%) formalin-fixed adenomas expressed immunoreactive COX-2.	Formaldehyde	18-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-72
10690533-3	2000	COX-2, one isoform of the COX enzyme, is the rate-limiting enzyme in prostaglandin synthesis, and the function of this enzyme is thought to relate to inflammatory processes and carcinogenesis.	Prostaglandins	69-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
10706474-6	2000	Irradiation with Ga-Al-As diode low-level laser significantly inhibited PGE2 production in a dose-dependent manner, which led to a reduction of COX-2 mRNA levels.	Dinoprostone	72-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	144-149
10706474-7	2000	In conclusion, low-level laser irradiation inhibited PGE2 by LPS in hGF cells through a reduction of COX-2 mRNA level.	Dinoprostone	53-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-106
10664917-2	2000	Celecoxib, an antiarthritic agent that inhibits COX-2 but spares COX-1 at therapeutic doses, is expected to have minimal effects on platelet function.	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-53
10766441-4	2000	All Co(II)-substituted peptide complexes adopt tetrahedral ligand geometries and have S- -->Co(II) ligand-to-metal charge-transfer (LMCT) transition intensities consistent with three Co(II)-S bonds for F1-SC and F1-CS.	Cesium	218-220	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
10766441-6	2000	Like the Co(II) derivative, the absorption spectrum of Ni(II)-substituted NCP 21-80 is most consistent with tetrahedral Ni(II) complexes with multiple thiolate donors.	Nickel(2+)	55-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	9-15
10766441-10	2000	Co(II) and Cd(II) complexes of non-native F1-CS peptides are more sensitive to oxidation by O2, relative to F1-SC, suggestive of a higher lability in the non-native chelate.	Oxygen	92-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
10877525-4	2000	However, such drugs may also trigger unwanted effects; for example, the COX-2 inhibitors, which reduce the production of one type of eicosanoids, the prostaglandins, may increase the production of other eicosanoids; i.e., the leukotriene B4 (LTB4), which is one of the most potent endogenous chemotactic/inflammatory factors.	Eicosanoids	133-144	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
10647695-1	2000	PURPOSE: To quantitate the effects of a selective cyclooxygenase (COX)-2 inhibitor, NS-398, on porcine and human ureteral contractility in vitro.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	84-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-72
10647695-27	2000	CONCLUSION: A selective COX-2 inhibitor (NS-398) reduces ureteral contractility as effectively as indomethacin (a nonselective COX inhibitor) in both porcine and human ureteral segments in vitro (p <0.05).	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	41-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
10877525-4	2000	However, such drugs may also trigger unwanted effects; for example, the COX-2 inhibitors, which reduce the production of one type of eicosanoids, the prostaglandins, may increase the production of other eicosanoids; i.e., the leukotriene B4 (LTB4), which is one of the most potent endogenous chemotactic/inflammatory factors.	Prostaglandins	150-164	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
10877525-4	2000	However, such drugs may also trigger unwanted effects; for example, the COX-2 inhibitors, which reduce the production of one type of eicosanoids, the prostaglandins, may increase the production of other eicosanoids; i.e., the leukotriene B4 (LTB4), which is one of the most potent endogenous chemotactic/inflammatory factors.	Eicosanoids	203-214	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
10877525-4	2000	However, such drugs may also trigger unwanted effects; for example, the COX-2 inhibitors, which reduce the production of one type of eicosanoids, the prostaglandins, may increase the production of other eicosanoids; i.e., the leukotriene B4 (LTB4), which is one of the most potent endogenous chemotactic/inflammatory factors.	Leukotriene B4	226-240	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
10877525-4	2000	However, such drugs may also trigger unwanted effects; for example, the COX-2 inhibitors, which reduce the production of one type of eicosanoids, the prostaglandins, may increase the production of other eicosanoids; i.e., the leukotriene B4 (LTB4), which is one of the most potent endogenous chemotactic/inflammatory factors.	Leukotriene B4	242-246	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
11193162-5	2000	We now show that neuroimmunophilin ligands (like cyclosporin A or FK-506) and nonsteroidal antiinflammatory agents (NSAIDs), including cyclooxygenase (COX)-2 inhibitors, can also prevent APP overexpression and the overproduction of amyloidogenic peptides.	Tacrolimus	66-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-157
10701683-3	2000	We examined the regulation of COX-2 mRNA and protein expression in response to both glucocorticoids (GC) and FK506 using rheumatoid synovial fibroblasts.	Tacrolimus	109-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-35
10701683-4	2000	Combined treatment of FK506 and a low concentration of dexamethasone (DEX) (10(-9) M) down-regulated synovial COX-2 mRNA and protein expression.	Tacrolimus	22-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-115
10701683-4	2000	Combined treatment of FK506 and a low concentration of dexamethasone (DEX) (10(-9) M) down-regulated synovial COX-2 mRNA and protein expression.	Dexamethasone	55-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-115
10701683-4	2000	Combined treatment of FK506 and a low concentration of dexamethasone (DEX) (10(-9) M) down-regulated synovial COX-2 mRNA and protein expression.	Dexamethasone	70-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-115
10701683-10	2000	Our results indicated that FK506-induced potentiation of GR-mediated repression of synovial COX-2 gene transcription is the result of increased translocation of GR to the nucleus and subsequent repression of NF-kappaB transactivation.	Tacrolimus	27-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-97
10721503-0	2000	Automated docking and molecular dynamics simulations of nimesulide in the cyclooxygenase active site of human prostaglandin-endoperoxide synthase-2 (COX-2).	nimesulide	56-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	149-154
10721503-1	2000	Molecular models of the complex between the selective COX-2 inhibitor nimesulide and the cyclooxygenase active site of human prostaglandin-endoperoxide synthase-2 have been built using a combination of homology modelling, conformational searching and automated docking techniques.	nimesulide	70-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-59
10721503-3	2000	It is found that nimesulide exploits the extra space made available by the replacement at position 523 of an isoleucine residue in COX-1 by a valine in COX-2 and establishes electrostatic interactions with both Arg-106 and Arg-499 (Arg-120 and Arg-513 in PGHS-1 numbering).	nimesulide	17-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-157
10678579-2	2000	Nonselective nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit both the COX-1 and COX-2 protein, the two enzymes that convert arachidonic acids to prostaglandins.	Arachidonic Acids	130-147	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-91
10678579-2	2000	Nonselective nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit both the COX-1 and COX-2 protein, the two enzymes that convert arachidonic acids to prostaglandins.	Prostaglandins	151-165	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-91
10678579-7	2000	COX-2 is inducible by oncogenes ras and scr, interleukin-1, hypoxia, benzo[a]pyrene, ultraviolet light, epidermal growth factor, transforming growth factor beta, and tumor necrosis factor alpha.	Benzo(a)pyrene	69-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
10678579-8	2000	Dexamethasone, antioxidants, and tumor-suppressor protein p53 suppress COX-2 expression.	Dexamethasone	0-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-76
11153163-10	2000	COX-1 was more inhibited by indomethacin and piroxicam and COX-2 by 6-MNA (active metabolite of nabumetone), diclofenac and ibuprofen.	6-methoxy-2-naphthylacetic acid	68-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-64
10678579-9	2000	COX-2 synthesizes prostaglandin E2 (PGE2) which stimulates bcl-2 and inhibits apoptosis, and induces interleukin-6 (IL-6) which enhances haptoglobin synthesis.	Dinoprostone	18-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
10678579-9	2000	COX-2 synthesizes prostaglandin E2 (PGE2) which stimulates bcl-2 and inhibits apoptosis, and induces interleukin-6 (IL-6) which enhances haptoglobin synthesis.	Dinoprostone	36-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
10966456-1	2000	The prostaglandin endoperoxide H synthases-1 and 2 (PGHS-1 and PGHS-2; also cyclooxygenases-1 and 2, COX-1 and COX-2) catalyze the committed step in prostaglandin synthesis.	Prostaglandins	4-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	111-116
10966456-1	2000	The prostaglandin endoperoxide H synthases-1 and 2 (PGHS-1 and PGHS-2; also cyclooxygenases-1 and 2, COX-1 and COX-2) catalyze the committed step in prostaglandin synthesis.	Prostaglandins	149-162	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	111-116
10643694-1	2000	In summary, COX-2 is a highly regulated gene product that catalyzes the local production of PGs in pathologic and physiologic situations (Figure 1).	Phosphatidylglycerols	92-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-17
10643694-2	2000	It is clear that COX-2 is the isoform responsible for production of the PGs that mediate inflammation, pain, and fever.	Phosphatidylglycerols	72-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22
12718676-7	2000	Mechanisms of Action: NSAIDs appear to act via depression of prostaglandin synthesis through inhibiting COX-2, often overexpressed in cancers, and the resultant suppression of proliferation, possibly through enhancement of apoptosis.	Prostaglandins	61-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
11153163-10	2000	COX-1 was more inhibited by indomethacin and piroxicam and COX-2 by 6-MNA (active metabolite of nabumetone), diclofenac and ibuprofen.	Nabumetone	96-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-64
11153163-10	2000	COX-1 was more inhibited by indomethacin and piroxicam and COX-2 by 6-MNA (active metabolite of nabumetone), diclofenac and ibuprofen.	Diclofenac	109-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-64
11153163-10	2000	COX-1 was more inhibited by indomethacin and piroxicam and COX-2 by 6-MNA (active metabolite of nabumetone), diclofenac and ibuprofen.	Ibuprofen	124-133	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-64
11153163-11	2000	Nimesulide and meloxicam selectively block COX-2 and are recommended to patients at risk or treated with diuretics.	nimesulide	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
11153163-11	2000	Nimesulide and meloxicam selectively block COX-2 and are recommended to patients at risk or treated with diuretics.	Meloxicam	15-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
11035430-4	2000	Both non-selective Cox inhibitors and selective Cox-2 inhibitors induce renal side effects, including sodium retention and reduction of the glomerular filtration rate.	Sodium	102-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-53
11199547-0	2000	The new COX-2 inhibitors: rofecoxib (Vioxx) and celecoxib (Celebrex).	rofecoxib	26-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	8-13
11199547-0	2000	The new COX-2 inhibitors: rofecoxib (Vioxx) and celecoxib (Celebrex).	rofecoxib	37-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	8-13
11199547-0	2000	The new COX-2 inhibitors: rofecoxib (Vioxx) and celecoxib (Celebrex).	Celecoxib	48-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	8-13
11199547-0	2000	The new COX-2 inhibitors: rofecoxib (Vioxx) and celecoxib (Celebrex).	Celecoxib	59-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	8-13
10954195-3	2000	Sco1/2 proteins have been isolated as high-copy number suppressors of a deletion of copper chaperone Cox 17, implicating Sco1/2 in copper transport to COX subunits I or II.	Copper	84-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-171
10954195-3	2000	Sco1/2 proteins have been isolated as high-copy number suppressors of a deletion of copper chaperone Cox 17, implicating Sco1/2 in copper transport to COX subunits I or II.	Copper	131-137	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-171
10656441-5	2000	The COX-2 overexpressed cases showed significantly elevated levels of prostaglandin E2 (PGE2) in cancer tissues in comparison with the normal gastric mucosa by an immunoassay (201 +/- 90 versus 161 +/- 57 ng/mg protein; P < 0.05).	Dinoprostone	70-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
10656441-5	2000	The COX-2 overexpressed cases showed significantly elevated levels of prostaglandin E2 (PGE2) in cancer tissues in comparison with the normal gastric mucosa by an immunoassay (201 +/- 90 versus 161 +/- 57 ng/mg protein; P < 0.05).	Dinoprostone	88-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
10656441-8	2000	Our data thus suggested COX-2 overexpression to be associated with increased PGE2 biosynthesis and angiogenesis in gastric cancer, which indicates that COX-2 may play a role in the development of gastric cancer.	Dinoprostone	77-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
10656441-8	2000	Our data thus suggested COX-2 overexpression to be associated with increased PGE2 biosynthesis and angiogenesis in gastric cancer, which indicates that COX-2 may play a role in the development of gastric cancer.	Dinoprostone	77-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-157
11055820-1	2000	The prostaglandin series of bioactive compounds is formed by the interaction of two distinct but related enzymes, cyclo-oxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2).	Prostaglandins	4-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	162-167
11055820-4	2000	Both isoforms contribute to the inflammatory process, but COX-2 is of considerable therapeutic interest as it is induced, resulting in an enhanced formation of prostaglandins, during acute as well as chronic inflammation.	Prostaglandins	160-174	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
11055820-6	2000	The two recently developed and clinically available selective COX-2 inhibitors, celecoxib and rofecoxib, are about 100-1000 times more selective on the COX-2 than on the COX-1 isoform.	Celecoxib	80-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
11055820-6	2000	The two recently developed and clinically available selective COX-2 inhibitors, celecoxib and rofecoxib, are about 100-1000 times more selective on the COX-2 than on the COX-1 isoform.	Celecoxib	80-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-157
11055820-6	2000	The two recently developed and clinically available selective COX-2 inhibitors, celecoxib and rofecoxib, are about 100-1000 times more selective on the COX-2 than on the COX-1 isoform.	rofecoxib	94-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
11055820-6	2000	The two recently developed and clinically available selective COX-2 inhibitors, celecoxib and rofecoxib, are about 100-1000 times more selective on the COX-2 than on the COX-1 isoform.	rofecoxib	94-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-157
11055820-10	2000	However, the well known contraindications for NSAIDs, such as late pregnancy, aspirin-induced asthma, congestive heart failure and renal dysfunction, will so far apply also to the COX-2 inhibitors.	Aspirin	78-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	180-185
10841069-15	2000	Furthermore, the active metabolite [6-methoxy-2-naphthylacetic acid (6-MNA)] may be gastro-sparing as a result of its property of COX-2 preferential inhibition.	6-methoxy-2-naphthylacetic acid	36-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	130-135
10841069-15	2000	Furthermore, the active metabolite [6-methoxy-2-naphthylacetic acid (6-MNA)] may be gastro-sparing as a result of its property of COX-2 preferential inhibition.	6-methoxy-2-naphthylacetic acid	69-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	130-135
10841071-3	2000	This nonacidic prodrug with an active 6-methoxy-2-naphthylacetic acid (6-MNA) metabolite has COX-2 preferential features and is also devoid of enterohepatic recirculation.	6-methoxy-2-naphthylacetic acid	38-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-98
10841071-3	2000	This nonacidic prodrug with an active 6-methoxy-2-naphthylacetic acid (6-MNA) metabolite has COX-2 preferential features and is also devoid of enterohepatic recirculation.	6-methoxy-2-naphthylacetic acid	71-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-98
11249549-0	2000	Nimesulide: an NSAID that preferentially inhibits COX-2, and has various unique pharmacological activities.	nimesulide	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-55
11249549-4	2000	The main novel pharmacological actions obtained using nimesulide in vivo at therapeutic doses, or in vitro at concentrations within the therapeutic range of free (unbound) drug, include: a preferential inhibition of prostaglandin synthesis via COX-2, and reductions in cytokine action/release, histamine release, the release of enzymes that degrade cartilage, and the release of superoxide anions and other toxic substances from neutrophils.	nimesulide	54-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	244-249
10609518-3	2000	In addition, mRNA expression of the inducible form of cyclooxygenase (COX-2), but not the constitutive form (COX-1), the major enzymes in prostaglandin production, was increased by PFF.	Prostaglandins	138-151	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-75
18475936-0	2000	Synthesis, Characterization and Biological Properties of Anions of Bivalent Transition Metal [Co(II) and Ni(II)] Complexes With Acylhydrazine Derived ONO Donor Schiff Bases.	Metals	87-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-100
18475936-0	2000	Synthesis, Characterization and Biological Properties of Anions of Bivalent Transition Metal [Co(II) and Ni(II)] Complexes With Acylhydrazine Derived ONO Donor Schiff Bases.	acylhydrazine	128-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-100
18475936-0	2000	Synthesis, Characterization and Biological Properties of Anions of Bivalent Transition Metal [Co(II) and Ni(II)] Complexes With Acylhydrazine Derived ONO Donor Schiff Bases.	Nitrogen Dioxide	150-153	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-100
11213386-5	2000	Recently, highly selective COX-2 inhibitors have been developed such as celecoxib (Celebrex) and rofecoxib (Vioxx).	Celecoxib	72-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-32
18475936-0	2000	Synthesis, Characterization and Biological Properties of Anions of Bivalent Transition Metal [Co(II) and Ni(II)] Complexes With Acylhydrazine Derived ONO Donor Schiff Bases.	Schiff Bases	160-172	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-100
18475936-1	2000	Some acylhydrazine derived ONO donor Schiff bases and their Co(II) and Ni(II) complexes have been prepared having the same metal ion (cation) but different anions.	acylhydrazine	5-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-66
18475936-1	2000	Some acylhydrazine derived ONO donor Schiff bases and their Co(II) and Ni(II) complexes have been prepared having the same metal ion (cation) but different anions.	Nitrogen Dioxide	27-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-66
18475936-1	2000	Some acylhydrazine derived ONO donor Schiff bases and their Co(II) and Ni(II) complexes have been prepared having the same metal ion (cation) but different anions.	Metals	123-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-66
18475943-0	2000	Symmetric 1,1"-Dimethylferrocene-Derived Amino Acids: Their Synthesis, Characterization, Ligational and Biological Properties With Cu(II), Co(II) and Ni(II) Ions.	1,1'-dimethylferrocene	10-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-145
11213386-5	2000	Recently, highly selective COX-2 inhibitors have been developed such as celecoxib (Celebrex) and rofecoxib (Vioxx).	Celecoxib	83-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-32
11213386-5	2000	Recently, highly selective COX-2 inhibitors have been developed such as celecoxib (Celebrex) and rofecoxib (Vioxx).	rofecoxib	97-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-32
11213386-5	2000	Recently, highly selective COX-2 inhibitors have been developed such as celecoxib (Celebrex) and rofecoxib (Vioxx).	rofecoxib	108-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-32
10859997-2	2000	Selective COX-2 inhibitors (i.e. celecoxib, rofecoxib) have demonstrated in clinical trials better gastrointestinal tolerability but their safety in patients with active ulcer, cardiovascular or renal disease has still to be further investigated.	Celecoxib	33-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
10692251-6	2000	The COX-2 selective inhibitor, SC-236, significantly reduced prostaglandin synthesis, both in its COX-2 specific and higher, non-specific concentration ranges.	4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide	31-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
10692251-6	2000	The COX-2 selective inhibitor, SC-236, significantly reduced prostaglandin synthesis, both in its COX-2 specific and higher, non-specific concentration ranges.	4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide	31-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-103
10692251-6	2000	The COX-2 selective inhibitor, SC-236, significantly reduced prostaglandin synthesis, both in its COX-2 specific and higher, non-specific concentration ranges.	Prostaglandins	61-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
10692251-6	2000	The COX-2 selective inhibitor, SC-236, significantly reduced prostaglandin synthesis, both in its COX-2 specific and higher, non-specific concentration ranges.	Prostaglandins	61-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-103
10692251-8	2000	CONCLUSIONS: Fetal membranes contain both COX-1 and COX-2 at term, but only COX-2 contributes towards prostaglandin synthesis.	Prostaglandins	102-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-81
10692251-9	2000	COX-2 selective NSAI drugs will be as effective as non-selective agents in inhibition of fetal membrane prostaglandin synthesis and may represent a new strategy for tocolysis.	Prostaglandins	104-117	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
11552612-2	2000	The advantages of VOLTAREN are: efficacy in all NSAID indications, good tolerability, favourable COX-2/COX-1 ratio, the wide range of drug forms, long treatment experience and extremely acceptable cost-benefit ratio.	Diclofenac	18-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
10859997-2	2000	Selective COX-2 inhibitors (i.e. celecoxib, rofecoxib) have demonstrated in clinical trials better gastrointestinal tolerability but their safety in patients with active ulcer, cardiovascular or renal disease has still to be further investigated.	rofecoxib	44-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
10609815-3	1999	We compared the efficacy, safety, and tolerability of long-term therapy with celecoxib, a COX-1 sparing inhibitor of COX-2, with diclofenac, a non-specific COX inhibitor.	Celecoxib	77-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-122
10628591-2	1999	Although recognition of the differential activities of new and established NSAIDs on the activities of the cyclooxygenases (COXs) affecting production of inflammatory prostaglandins (from COX-2) and those that are physiologically important (from COX-1) may have significance for the prostaglandin components of the underlying inflammatory and physiologic processes, there are important features of their chemical structures that determine the various cellular and biochemical actions of these agents.	Prostaglandins	167-181	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	188-193
10628591-2	1999	Although recognition of the differential activities of new and established NSAIDs on the activities of the cyclooxygenases (COXs) affecting production of inflammatory prostaglandins (from COX-2) and those that are physiologically important (from COX-1) may have significance for the prostaglandin components of the underlying inflammatory and physiologic processes, there are important features of their chemical structures that determine the various cellular and biochemical actions of these agents.	Prostaglandins	167-180	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	188-193
15822301-3	1999	It has found that in aqueous solution, there exists a direct interaction of the metal ions of the active center in the metalloenzyme (Cu2Zn2SOD) with external added Co(His)n. As a result, part of the metal ions in metalloenzyme were replaced and the corresponding metalloenzyme derivatives (Co (II)-substituted derivatives of SOD) were produced and the catalytic activity of enzyme were affected.	Metals	80-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	291-297
10628593-8	1999	Patients using meloxicam experienced less dyspepsia (odds ratio = 0.73; 95% CI, 0.64-0.84), fewer PUBs (odds ratio = 0.52; 95% CI, 0.28-0.96), and less frequent discontinuation of NSAID because of adverse GI events (odds ratio = 0.59; 95% CI, 0.52-0.67) compared with non-COX-2 selective NSAIDs.	Meloxicam	15-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	272-277
10628593-9	1999	Meloxicam, a COX-2-selective NSAID, appears to cause fewer adverse GI events than standard, non-COX-2-selective NSAIDs.	Meloxicam	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
10645754-1	1999	Celecoxib is primarily an inhibitor of cyclooxygenase (COX) 2 and, at therapeutic concentrations in humans, does not inhibit the COX-1 isoenzyme.	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-61
15822301-3	1999	It has found that in aqueous solution, there exists a direct interaction of the metal ions of the active center in the metalloenzyme (Cu2Zn2SOD) with external added Co(His)n. As a result, part of the metal ions in metalloenzyme were replaced and the corresponding metalloenzyme derivatives (Co (II)-substituted derivatives of SOD) were produced and the catalytic activity of enzyme were affected.	cu2zn2sod	134-143	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	291-297
15822301-3	1999	It has found that in aqueous solution, there exists a direct interaction of the metal ions of the active center in the metalloenzyme (Cu2Zn2SOD) with external added Co(His)n. As a result, part of the metal ions in metalloenzyme were replaced and the corresponding metalloenzyme derivatives (Co (II)-substituted derivatives of SOD) were produced and the catalytic activity of enzyme were affected.	co(his	165-171	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	291-297
15822301-3	1999	It has found that in aqueous solution, there exists a direct interaction of the metal ions of the active center in the metalloenzyme (Cu2Zn2SOD) with external added Co(His)n. As a result, part of the metal ions in metalloenzyme were replaced and the corresponding metalloenzyme derivatives (Co (II)-substituted derivatives of SOD) were produced and the catalytic activity of enzyme were affected.	Metals	119-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	291-297
10569809-12	1999	Furthermore, the observed inhibitory effects of silymarin on COX-2 and IL-1alpha should be further explored to develop preventive strategies against those cancers in which these molecular targets play one of the causative roles, such as non-melanoma skin, colon, and breast cancers in humans.	Silymarin	48-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-66
10669112-12	1999	However, rutaecarpine inhibited neither PLA2 and COX-1 activity nor COX-2 protein and mRNA expression up to the concentration of 30 microM in BMMC, indicating that rutaecarpine directly inhibited COX-2 activity.	rutecarpine	164-176	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	196-201
10669112-0	1999	A new class of COX-2 inhibitor, rutaecarpine from Evodia rutaecarpa.	rutecarpine	32-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-20
10669112-1	1999	OBJECTIVE AND DESIGN: We investigated the effect of a new class of COX-2 inhibitor, rutaecarpine, on the production of PGD2 in bone marrow derived mast cells (BMMC) and PGE2 in COX-2 transfected HEK293 cells.	rutecarpine	84-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-72
10669112-1	1999	OBJECTIVE AND DESIGN: We investigated the effect of a new class of COX-2 inhibitor, rutaecarpine, on the production of PGD2 in bone marrow derived mast cells (BMMC) and PGE2 in COX-2 transfected HEK293 cells.	rutecarpine	84-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	177-182
10669112-7	1999	COX-1 and COX-2 protein and mRNA expression was determined by BMMC in the presence of KL, LPS and IL-10.	Kraft lignin	86-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
10669112-10	1999	RESULTS: Rutaecarpine inhibited COX-2 and COX-1 dependent phases of PGD2 generation in BMMC in a concentration-dependent manner with an IC50 of 0.28 microM and 8.7 microM, respectively.	rutecarpine	9-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-37
10669112-11	1999	It inhibited COX-2-dependent conversion of exogenous arachidonic acid to PGE2 in a dose-dependent manner by the COX-2-transfected HEK293 cells.	Arachidonic Acid	53-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
10669112-11	1999	It inhibited COX-2-dependent conversion of exogenous arachidonic acid to PGE2 in a dose-dependent manner by the COX-2-transfected HEK293 cells.	Arachidonic Acid	53-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-117
10669112-11	1999	It inhibited COX-2-dependent conversion of exogenous arachidonic acid to PGE2 in a dose-dependent manner by the COX-2-transfected HEK293 cells.	Dinoprostone	73-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
10669112-11	1999	It inhibited COX-2-dependent conversion of exogenous arachidonic acid to PGE2 in a dose-dependent manner by the COX-2-transfected HEK293 cells.	Dinoprostone	73-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-117
10639016-2	1999	Since aspirin is a weak inhibitor of the inducible isoform of prostaglandin H synthase (COX-2), it was suggested that COX-2 may play a role in aspirin resistance.	Aspirin	6-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-93
10639016-2	1999	Since aspirin is a weak inhibitor of the inducible isoform of prostaglandin H synthase (COX-2), it was suggested that COX-2 may play a role in aspirin resistance.	Aspirin	6-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-123
10639016-2	1999	Since aspirin is a weak inhibitor of the inducible isoform of prostaglandin H synthase (COX-2), it was suggested that COX-2 may play a role in aspirin resistance.	Aspirin	143-150	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-93
10639016-2	1999	Since aspirin is a weak inhibitor of the inducible isoform of prostaglandin H synthase (COX-2), it was suggested that COX-2 may play a role in aspirin resistance.	Aspirin	143-150	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-123
10639016-3	1999	However the cellular source(s) of COX-2 possibly responsible for aspirin resistance remains unknown.	Aspirin	65-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-39
10639016-6	1999	NS-398 was 180-fold more potent in inhibiting monocyte COX-2 activity than platelet TXB2 production.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	0-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-60
10639016-9	1999	Our results argue against the involvement of COX-2 in TX biosynthesis by activated platelets and consequently dispute platelet COX-2 expression as an important mechanism of aspirin resistance.	Aspirin	173-180	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	127-132
10581086-3	1999	However, NSAIDs produce gastroduodenal ulcers in about 25% of users (often with bleeding and/or perforations) and delay ulcer healing, presumably by blocking prostaglandin synthesis from cyclooxygenase (COX)-1 and COX-2 (ref.	Prostaglandins	158-171	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	214-219
10581086-6	1999	11), prompted the development of NSAIDs that selectively inhibit only COX-2 (such as celecoxib and rofecoxib).	Celecoxib	85-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-75
10576684-1	1999	By inserting an oxygen link between the 3-fluorophenyl and the lactone ring of 5,5-dimethyl-3-(3fluorophenyl)-4-(4-methanesulfonylphenyl)-2 (5H)-furanone 1 (DFU), analogs with enhanced in vitro COX-2 inhibitory potency as well as in vivo potency in models of inflammation were obtained.	Oxygen	16-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	194-199
10580458-2	1999	Rofecoxib specifically inhibits COX-2 and has demonstrated a low potential for causing upper GI injury.	rofecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-37
10576684-1	1999	By inserting an oxygen link between the 3-fluorophenyl and the lactone ring of 5,5-dimethyl-3-(3fluorophenyl)-4-(4-methanesulfonylphenyl)-2 (5H)-furanone 1 (DFU), analogs with enhanced in vitro COX-2 inhibitory potency as well as in vivo potency in models of inflammation were obtained.	Lactones	63-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	194-199
10576684-1	1999	By inserting an oxygen link between the 3-fluorophenyl and the lactone ring of 5,5-dimethyl-3-(3fluorophenyl)-4-(4-methanesulfonylphenyl)-2 (5H)-furanone 1 (DFU), analogs with enhanced in vitro COX-2 inhibitory potency as well as in vivo potency in models of inflammation were obtained.	5,5-dimethyl-3-(3fluorophenyl)-4-(4-methanesulfonylphenyl)-2 (5h)-furanone	79-153	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	194-199
10576685-0	1999	Synthesis and biological evaluation of 3-heteroaryloxy-4-phenyl-2(5H)-furanones as selective COX-2 inhibitors.	3-heteroaryloxy-4-phenyl-2(5h)-furanones	39-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-98
10576685-1	1999	A series of 3-heteroaryloxy4-phenyl-2-5H)-furanones were prepared and evaluated for their potency and selectivity as COX-2 inhibitors.	3-heteroaryloxy4-phenyl-2-5h)-furanones	12-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-122
10576685-2	1999	This led to the identification of L-778,736 as a potent, orally active and selective inhibitor of the COX-2 enzyme.	l-778	34-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-107
10564233-5	1999	In contrast, the specific COX-2 inhibitor NS-398 (50 microM) in lumen and bath abolished the stimulating effect of low luminal NaCl (12.8 +/- 3.9 nGU/min at high NaCl, and 10.7 +/- 3.1 nGU/min at low NaCl; NS, n = 15).	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	42-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-31
10567324-0	1999	Serotonin-induced coronary contraction increases after blood cardioplegia-reperfusion: role of COX-2 expression.	Serotonin	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-100
10567324-7	1999	Serotonin caused a minimal dilation under baseline conditions but after CP-Rep elicited a potent contractile response that was inhibited in the presence of the selective inducible cyclooxygenase (COX-2) inhibitor NS398.	Serotonin	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	196-201
10567324-7	1999	Serotonin caused a minimal dilation under baseline conditions but after CP-Rep elicited a potent contractile response that was inhibited in the presence of the selective inducible cyclooxygenase (COX-2) inhibitor NS398.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	213-218	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	196-201
10567324-10	1999	Expression and protein level of COX-2 were significantly increased after CP-Rep.	cp-rep	73-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-37
10567324-12	1999	CONCLUSIONS: CP-Rep increases serotonin-induced contraction of human microvessels caused by the release of products of COX-2 and the impaired release of nitric oxide.	cp-rep	13-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-124
10567324-12	1999	CONCLUSIONS: CP-Rep increases serotonin-induced contraction of human microvessels caused by the release of products of COX-2 and the impaired release of nitric oxide.	Serotonin	30-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-124
10564233-5	1999	In contrast, the specific COX-2 inhibitor NS-398 (50 microM) in lumen and bath abolished the stimulating effect of low luminal NaCl (12.8 +/- 3.9 nGU/min at high NaCl, and 10.7 +/- 3.1 nGU/min at low NaCl; NS, n = 15).	Sodium Chloride	127-131	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-31
10564233-5	1999	In contrast, the specific COX-2 inhibitor NS-398 (50 microM) in lumen and bath abolished the stimulating effect of low luminal NaCl (12.8 +/- 3.9 nGU/min at high NaCl, and 10.7 +/- 3.1 nGU/min at low NaCl; NS, n = 15).	Sodium Chloride	162-166	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-31
10564233-5	1999	In contrast, the specific COX-2 inhibitor NS-398 (50 microM) in lumen and bath abolished the stimulating effect of low luminal NaCl (12.8 +/- 3.9 nGU/min at high NaCl, and 10.7 +/- 3.1 nGU/min at low NaCl; NS, n = 15).	Sodium Chloride	162-166	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-31
10564233-6	1999	The finding that COX-2 is critically involved in macula densa control of renin secretion indicates that the COX-2-expressing epithelial cells in the tubuloglomerular contact area are a likely source of prostaglandins participating in the signaling pathway between the macula densa and renin-producing granular cells.	Prostaglandins	202-216	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22
10564233-6	1999	The finding that COX-2 is critically involved in macula densa control of renin secretion indicates that the COX-2-expressing epithelial cells in the tubuloglomerular contact area are a likely source of prostaglandins participating in the signaling pathway between the macula densa and renin-producing granular cells.	Prostaglandins	202-216	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-113
11671255-5	1999	Electrochemical studies indicate that the adsorbed Co(II) complex on the surface of mercury is the active catalyst for the reduction of protons to dihydrogen.	Mercury	84-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-57
16113982-3	1999	From these we have selected excitability blockers acting on sodium and calcium channels, progress in drugs acting at glutamate receptors, cannabinoid receptors, capsaicin analogs, novel opioids acting at receptors other than the mu receptor for morphine, substance P antagonists and cyclooxygenase (COX)-2 inhibitors as being of particular interest.	Morphine	245-253	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	283-305
10598013-4	1999	RESULTS: GTW inhibited prostaglandin E2 production by IL-1beta-stimulated synovial cells in a concentration-dependent manner, and also inhibited COX-2 protein and mRNA expression in a similar fashion to dexamethasone.	GTW	9-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-150
10598013-7	1999	CONCLUSION: The anti-rheumatic effect of GTW or TWHF may be partly mediated through the inhibition of prostaglandin E2 production in human synovial cells due to suppression of COX-2 mRNA, possibly via inhibition of nuclear factor-kappaB activity.	GTW	41-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	176-181
10692773-2	1999	One truly selective COX-2 agent--celecoxib--is now being marketed in an ever increasing number of countries.	Celecoxib	33-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-25
11062611-5	1999	New NSAIDs that block only prostaglandins at sites of inflammation (COX-2 selective NSAIDs) may be significantly safer than traditional NSAIDs.	Prostaglandins	27-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-73
10593169-0	1999	Biochemical changes in prostanoids and cerebral expression of cyclooxygenase (COX)-1 and COX-2 during morphine sulfate infusion in the newborn piglet .	Morphine	102-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-94
10531345-5	1999	Both types IIA and V sPLA(2), the AA released by which was efficiently converted to prostaglandin E(2), markedly augmented IL-1-induced expression of cyclooxygenase (COX)-2 in a heparin-sensitive fashion, whereas type X sPLA(2) lacked the ability to augment COX-2 expression, thereby exhibiting the poor prostaglandin E(2)-biosynthetic response unless either of the COX isozymes was forcibly introduced into type X sPLA(2)-expressing cells.	Prostaglandins E	84-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	150-172
10531345-5	1999	Both types IIA and V sPLA(2), the AA released by which was efficiently converted to prostaglandin E(2), markedly augmented IL-1-induced expression of cyclooxygenase (COX)-2 in a heparin-sensitive fashion, whereas type X sPLA(2) lacked the ability to augment COX-2 expression, thereby exhibiting the poor prostaglandin E(2)-biosynthetic response unless either of the COX isozymes was forcibly introduced into type X sPLA(2)-expressing cells.	Heparin	178-185	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	150-172
10531345-5	1999	Both types IIA and V sPLA(2), the AA released by which was efficiently converted to prostaglandin E(2), markedly augmented IL-1-induced expression of cyclooxygenase (COX)-2 in a heparin-sensitive fashion, whereas type X sPLA(2) lacked the ability to augment COX-2 expression, thereby exhibiting the poor prostaglandin E(2)-biosynthetic response unless either of the COX isozymes was forcibly introduced into type X sPLA(2)-expressing cells.	Dinoprostone	84-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	150-172
10531345-5	1999	Both types IIA and V sPLA(2), the AA released by which was efficiently converted to prostaglandin E(2), markedly augmented IL-1-induced expression of cyclooxygenase (COX)-2 in a heparin-sensitive fashion, whereas type X sPLA(2) lacked the ability to augment COX-2 expression, thereby exhibiting the poor prostaglandin E(2)-biosynthetic response unless either of the COX isozymes was forcibly introduced into type X sPLA(2)-expressing cells.	Dinoprostone	84-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	258-263
10514475-8	1999	We therefore propose that a GPI-anchored HSPG glypican facilitates the trafficking of sPLA(2)-IIA into particular subcellular compartments, and arachidonic acid thus released from the compartments may link efficiently to the downstream COX-2-mediated PG biosynthesis.	Arachidonic Acid	144-160	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	236-241
10514475-8	1999	We therefore propose that a GPI-anchored HSPG glypican facilitates the trafficking of sPLA(2)-IIA into particular subcellular compartments, and arachidonic acid thus released from the compartments may link efficiently to the downstream COX-2-mediated PG biosynthesis.	Prostaglandins	43-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	236-241
10486321-6	1999	This mutation changes a methionine to a lysine residue in the middle of the first N-terminal membrane-spanning region of COX II.	Methionine	24-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-127
10486321-6	1999	This mutation changes a methionine to a lysine residue in the middle of the first N-terminal membrane-spanning region of COX II.	Lysine	40-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-127
10486321-9	1999	These observations suggest that, in the COX protein, a structural association of COX II with COX I is necessary to stabilize the binding of heme a3 to COX I.	Heme	140-144	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-87
10643175-3	1999	Prostaglandins (PGs) formed by the enzymatic activity of COX-1 are primarily involved in the regulation of homeostatic functions throughout the body, whereas PGs formed by COX-2 primarily mediate pain and inflammation.	Prostaglandins	158-161	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	172-177
10643175-5	1999	By preserving the synthesis of homeostatic PGs, these specific inhibitors of COX-2 provide the clinical benefits of nonsteroidal anti-inflammatory drugs and minimize the consequences of nonspecific inhibition of PG synthesis.	Prostaglandins	43-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-82
10643175-5	1999	By preserving the synthesis of homeostatic PGs, these specific inhibitors of COX-2 provide the clinical benefits of nonsteroidal anti-inflammatory drugs and minimize the consequences of nonspecific inhibition of PG synthesis.	Prostaglandins	43-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-82
26981701-3	1999	Prostaglandins (PGs) formed by the enzymatic activity of COX-l are primarily involved in the regulation of homeostatic functions throughout the body, whereas PGs formed by COX-2 primarily mediate pain and inflammation.	Prostaglandins	158-161	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	172-177
26981701-5	1999	By preserving the synthesis of homeostatic PGs, these specific inhibitors of COX-2 provide the clinical benefits of nonsteroidal anti-inflammatory drugs and minimize the consequences of nonspecific inhibition of PG synthesis.	Prostaglandins	43-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-82
26981701-5	1999	By preserving the synthesis of homeostatic PGs, these specific inhibitors of COX-2 provide the clinical benefits of nonsteroidal anti-inflammatory drugs and minimize the consequences of nonspecific inhibition of PG synthesis.	Prostaglandins	43-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-82
10595652-1	1999	Our previous study showed that vanadate, an inhibitor of protein tyrosine phosphatases, induced the expression of cyclo-oxygenase (COX)-2 in a protein-tyrosine-kinase (PTK)-dependent manner in human umbilical vein endothelial cells (HUVEC).	Vanadates	31-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-137
10595652-2	1999	Here, we further compared the actions of vanadate and phorbol 12-myristate 13-acetate (PMA), an activator of protein kinase C (PKC), on induction of COX-2 with special reference to mitogen-activated protein kinases (MAPKs) in HUVEC.	Vanadates	41-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	149-154
10595652-2	1999	Here, we further compared the actions of vanadate and phorbol 12-myristate 13-acetate (PMA), an activator of protein kinase C (PKC), on induction of COX-2 with special reference to mitogen-activated protein kinases (MAPKs) in HUVEC.	Tetradecanoylphorbol Acetate	54-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	149-154
10595652-2	1999	Here, we further compared the actions of vanadate and phorbol 12-myristate 13-acetate (PMA), an activator of protein kinase C (PKC), on induction of COX-2 with special reference to mitogen-activated protein kinases (MAPKs) in HUVEC.	Tetradecanoylphorbol Acetate	87-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	149-154
10595652-5	1999	Either tyrphostin-47, PD98059, a specific inhibitor of the upstream kinase toward ERK1/2, or SB203580, a specific inhibitor of p38, completely suppressed vanadate-induction of COX-2 mRNA and protein.	tyrphostin 47	7-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	176-181
10595652-5	1999	Either tyrphostin-47, PD98059, a specific inhibitor of the upstream kinase toward ERK1/2, or SB203580, a specific inhibitor of p38, completely suppressed vanadate-induction of COX-2 mRNA and protein.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	22-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	176-181
10595652-5	1999	Either tyrphostin-47, PD98059, a specific inhibitor of the upstream kinase toward ERK1/2, or SB203580, a specific inhibitor of p38, completely suppressed vanadate-induction of COX-2 mRNA and protein.	SB 203580	93-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	176-181
10595652-5	1999	Either tyrphostin-47, PD98059, a specific inhibitor of the upstream kinase toward ERK1/2, or SB203580, a specific inhibitor of p38, completely suppressed vanadate-induction of COX-2 mRNA and protein.	Vanadates	154-162	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	176-181
10595652-7	1999	These data indicate that PMA-induced and PKC-dependent expression of COX-2 requires mainly activation of ERK 1/2 among MAPKs, while activation of both ERK1/2 and p38 or possibly of all three families of MAPKs is necessary for vanadate-induced and PTK-dependent expression of COX-2.	Tetradecanoylphorbol Acetate	25-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-74
10595652-7	1999	These data indicate that PMA-induced and PKC-dependent expression of COX-2 requires mainly activation of ERK 1/2 among MAPKs, while activation of both ERK1/2 and p38 or possibly of all three families of MAPKs is necessary for vanadate-induced and PTK-dependent expression of COX-2.	Tetradecanoylphorbol Acetate	25-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	275-280
10595652-7	1999	These data indicate that PMA-induced and PKC-dependent expression of COX-2 requires mainly activation of ERK 1/2 among MAPKs, while activation of both ERK1/2 and p38 or possibly of all three families of MAPKs is necessary for vanadate-induced and PTK-dependent expression of COX-2.	Vanadates	226-234	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-74
11671162-2	1999	The isotropically shifted (1)H NMR signals of the Co(II) complexes of two 2,6-diamidopyridine-containing dendrimers have been fully assigned by means of 1D and 2D NMR techniques, including NOE difference, EXSY, COSY, and TOCSY.	2,6-diamidopyridine	74-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-56
10514410-1	1999	Cyclooxygenase-1 (Cox-1) and Cox-2 convert arachidonic acid to prostaglandin H(2), the precursor of other prostaglandins and thromboxanes, eicosanoids important in vascular pathophysiology.	Arachidonic Acid	43-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34
10514410-1	1999	Cyclooxygenase-1 (Cox-1) and Cox-2 convert arachidonic acid to prostaglandin H(2), the precursor of other prostaglandins and thromboxanes, eicosanoids important in vascular pathophysiology.	Prostaglandin H2	63-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34
10514410-1	1999	Cyclooxygenase-1 (Cox-1) and Cox-2 convert arachidonic acid to prostaglandin H(2), the precursor of other prostaglandins and thromboxanes, eicosanoids important in vascular pathophysiology.	Prostaglandins	106-120	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34
10692773-7	1999	Another COX-2 agent--rofecoxib--is on the brink of being released.	rofecoxib	21-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	8-13
10514410-1	1999	Cyclooxygenase-1 (Cox-1) and Cox-2 convert arachidonic acid to prostaglandin H(2), the precursor of other prostaglandins and thromboxanes, eicosanoids important in vascular pathophysiology.	Thromboxanes	125-137	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34
10514410-1	1999	Cyclooxygenase-1 (Cox-1) and Cox-2 convert arachidonic acid to prostaglandin H(2), the precursor of other prostaglandins and thromboxanes, eicosanoids important in vascular pathophysiology.	Eicosanoids	139-150	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34
10486360-9	1999	Prostaglandin E(2) production and tubular structure formation by HuGE cells on basement membrane matrix was significantly inhibited by a selective COX-2 inhibitor (NS-398).	Dinoprostone	0-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-152
10566565-4	1999	This 8-week, double-masked, placebo-controlled trial was undertaken to assess the safety profile, tolerability, and effective dose range of once-daily rofecoxib, a COX-2-specific inhibitor, in the treatment of rheumatoid arthritis (RA).	rofecoxib	151-160	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	164-169
10506108-12	1999	The results show that the orally administered selective COX-2 inhibitor celecoxib prevents new tumor formation after the onset of photocarcinogenesis and suggest that treatment with celecoxib may be very useful in preventing UV-induced skin tumors in humans.	Celecoxib	72-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-61
10506108-12	1999	The results show that the orally administered selective COX-2 inhibitor celecoxib prevents new tumor formation after the onset of photocarcinogenesis and suggest that treatment with celecoxib may be very useful in preventing UV-induced skin tumors in humans.	Celecoxib	182-191	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-61
10500058-2	1999	BACKGROUND & AIMS: Prostaglandin production in the normal gastrointestinal tract, believed to be critical for mucosal integrity, is mediated by cyclooxygenase (COX)-1, whereas prostaglandin production at inflammatory sites seems to occur via induction of COX-2.	Prostaglandins	23-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	259-264
11139815-1	1999	Increased prostaglandin (PG) production is associated with many inflammatory pathophysiological conditions; it is derived from arachidonic acid by either of two enzymes: cyclooxygenase-1 or -2 (COX-1 or COX-2).	Prostaglandins	10-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	203-208
10486360-9	1999	Prostaglandin E(2) production and tubular structure formation by HuGE cells on basement membrane matrix was significantly inhibited by a selective COX-2 inhibitor (NS-398).	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	164-170	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-152
11139815-1	1999	Increased prostaglandin (PG) production is associated with many inflammatory pathophysiological conditions; it is derived from arachidonic acid by either of two enzymes: cyclooxygenase-1 or -2 (COX-1 or COX-2).	Prostaglandins	25-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	203-208
10500058-3	1999	We hypothesized that COX-2-specific inhibition with rofecoxib (25 mg once daily) in the treatment of patients with osteoarthritis would cause fewer gastroduodenal ulcers than an equally effective dose of ibuprofen (800 mg 3 times a day), a nonspecific COX inhibitor.	rofecoxib	52-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-26
10500058-3	1999	We hypothesized that COX-2-specific inhibition with rofecoxib (25 mg once daily) in the treatment of patients with osteoarthritis would cause fewer gastroduodenal ulcers than an equally effective dose of ibuprofen (800 mg 3 times a day), a nonspecific COX inhibitor.	Ibuprofen	204-213	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-26
11139815-2	1999	In addition to its role in inflammation, recent work suggests COX-2 derived prostaglandins may play a pivotal part in the maintenance of tumour viability, growth and metastasis.	Prostaglandins	76-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
10508225-3	1999	Cyclo-oxygenase (COX) is the rate-limiting enzyme in the synthesis of PGs and exists in two isoforms, COX-1 and COX-2.	Phosphatidylglycerols	70-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-117
10595745-1	1999	The anti-tumor effect of a selective cyclooxygenase (COX)-2 inhibitor, JTE-522, was examined with the human head and neck squamous cell carcinoma cell line KB.	4-(4-cyclohexyl-2-methyloxazol-5-yl)-2-fluorobenzenesulfonamide	71-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-59
10523372-4	1999	Recently, 2 isoforms of the enzyme responsible for prostaglandin synthesis, cyclooxygenase, have been described as cyclooxygenase-1 (COX-1), a constitutive isoform, and cyclooxygenase-2 (COX-2), an inducible isoform.	Prostaglandins	51-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	187-192
10523372-5	1999	In the present study, we investigated whether COX-2-dependent prostaglandins participate in the evolution of renal functional changes after renal ablation.	Prostaglandins	62-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
10523372-10	1999	These data suggest that COX-2-dependent prostaglandins participate in the renal mechanisms associated with the development of renal functional changes after renal ablation.	Prostaglandins	40-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
10508225-11	1999	After treatment with mifepristone, expression of COX-1 in glandular epithelium and COX-2 in luminal epithelium significantly decreased whilst the immunostaining for COX-2 in the perivascular cells remained strong.	Mifepristone	21-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
10508225-11	1999	After treatment with mifepristone, expression of COX-1 in glandular epithelium and COX-2 in luminal epithelium significantly decreased whilst the immunostaining for COX-2 in the perivascular cells remained strong.	Mifepristone	21-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	165-170
10508225-12	1999	This study shows the expression of both COX-1 and COX-2 during the implantation period and also indicates that treatment with mifepristone in early luteal phase impairs glandular epithelial function and endometrial receptivity.	Mifepristone	126-138	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-55
10504238-8	1999	The results identify the coenzyme"s on-board dimethylbenzimidazole moiety as the alpha-axial ligand to cob(II)alamin in ethanolamine deaminase in the substrate radical-Co(II) biradical catalytic intermediate state.	5,6-dimethylbenzimidazole	45-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	168-174
10504238-11	1999	A 14% increase in the isotropic hyperfine coupling of the remote dimethylbenzimidazole (14)N nucleus in enzyme-bound versus free base-on cob(II)alamin shows an enhanced delocalization of unpaired spin density from Co(II) onto the axial ligand, which would contribute to the acceleration of the cobalt-carbon bond cleavage rate in situ.	5,6-dimethylbenzimidazole	65-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	214-220
10504238-11	1999	A 14% increase in the isotropic hyperfine coupling of the remote dimethylbenzimidazole (14)N nucleus in enzyme-bound versus free base-on cob(II)alamin shows an enhanced delocalization of unpaired spin density from Co(II) onto the axial ligand, which would contribute to the acceleration of the cobalt-carbon bond cleavage rate in situ.	Cobalt	294-300	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	214-220
10504238-11	1999	A 14% increase in the isotropic hyperfine coupling of the remote dimethylbenzimidazole (14)N nucleus in enzyme-bound versus free base-on cob(II)alamin shows an enhanced delocalization of unpaired spin density from Co(II) onto the axial ligand, which would contribute to the acceleration of the cobalt-carbon bond cleavage rate in situ.	Carbon	301-307	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	214-220
10477618-0	1999	A novel mechanism of action of chemically modified tetracyclines: inhibition of COX-2-mediated prostaglandin E2 production.	Tetracyclines	51-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-85
10469538-0	1999	Sorption of Co(II) on Metal Oxide Surfaces.	metal oxide	22-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-18
10469549-1	1999	Adsorption of Pb(II), Cu(II), Zn(II), Co(II), and Mn(II) to kaolinite was measured at 25 degrees C in the presence of 5 mM KNO(3).	Kaolin	60-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-43
10477618-0	1999	A novel mechanism of action of chemically modified tetracyclines: inhibition of COX-2-mediated prostaglandin E2 production.	Dinoprostone	95-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-85
10469539-0	1999	Sorption of Co(II) on Metal Oxide Surfaces.	metal oxide	22-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-18
10477618-1	1999	Tetracyclines (doxycycline and minocycline) inhibit inducible NO synthase expression and augment cyclooxygenase (COX)-2 expression and PGE2 production.	Tetracyclines	0-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-119
10469539-4	1999	Based on EXAFS results and bond valence analysis, plausible surface complexation reactions for Co(II) sorption on these two surfaces can be written as represent surface water molecules, hydroxyl groups, and oxygens bonded to one, two, and three Al cations, respectively.	Water	169-174	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-101
10477618-1	1999	Tetracyclines (doxycycline and minocycline) inhibit inducible NO synthase expression and augment cyclooxygenase (COX)-2 expression and PGE2 production.	Doxycycline	15-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-119
10469539-4	1999	Based on EXAFS results and bond valence analysis, plausible surface complexation reactions for Co(II) sorption on these two surfaces can be written as represent surface water molecules, hydroxyl groups, and oxygens bonded to one, two, and three Al cations, respectively.	Oxygen	207-214	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-101
10469539-4	1999	Based on EXAFS results and bond valence analysis, plausible surface complexation reactions for Co(II) sorption on these two surfaces can be written as represent surface water molecules, hydroxyl groups, and oxygens bonded to one, two, and three Al cations, respectively.	Aluminum	245-247	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-101
10477618-1	1999	Tetracyclines (doxycycline and minocycline) inhibit inducible NO synthase expression and augment cyclooxygenase (COX)-2 expression and PGE2 production.	Minocycline	31-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-119
10484518-5	1999	Transduction with a COX2 antisense adenovirus reduced MIC COX2 protein expression and also decreased PGE2 production.	Dinoprostone	101-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-24
10484518-7	1999	Similarly, the COX2-selective inhibitor SC-58236 (30 microM) and several nonselective COX-inhibiting nonsteroidal anti-inflammatory drugs (NSAIDs), including sulindac, ibuprofen, and indomethacin, all caused MIC death.	4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide	40-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-19
10484519-8	1999	These data suggest that TNF-mediated induction of COX-2 protein expression accounted for the lag-time required for this cytokine to inhibit 86Rb uptake in MTAL cells.	Rubidium-86	140-144	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-55
10484519-2	1999	In the present study, we demonstrated that the COX-2-selective inhibitor, NS-398, prevented tumor necrosis factor-alpha (TNF)- and phorbol myristate acetate (PMA)-mediated increases in PGE(2) production by cultured MTAL cells.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	74-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
10487857-2	1999	We report that overexpression of neuronal hCOX-2 potentiates the intensity and lethality of kainic acid excitotoxicity in coincidence with potentiation of expression of the immediate early genes c-fos and zif-268.	Kainic Acid	92-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-48
10484519-2	1999	In the present study, we demonstrated that the COX-2-selective inhibitor, NS-398, prevented tumor necrosis factor-alpha (TNF)- and phorbol myristate acetate (PMA)-mediated increases in PGE(2) production by cultured MTAL cells.	Tetradecanoylphorbol Acetate	131-156	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
10487857-3	1999	In vitro studies extended the in vivo findings and revealed that glutamate excitotoxicity is potentiated in primary cortico-hippocampal neurons derived from hCOX-2 transgenic mice, possibly through potentiation of mitochondrial impairment.	Glutamic Acid	65-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	157-163
10484519-2	1999	In the present study, we demonstrated that the COX-2-selective inhibitor, NS-398, prevented tumor necrosis factor-alpha (TNF)- and phorbol myristate acetate (PMA)-mediated increases in PGE(2) production by cultured MTAL cells.	Tetradecanoylphorbol Acetate	158-161	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
10484519-2	1999	In the present study, we demonstrated that the COX-2-selective inhibitor, NS-398, prevented tumor necrosis factor-alpha (TNF)- and phorbol myristate acetate (PMA)-mediated increases in PGE(2) production by cultured MTAL cells.	Prostaglandins E	185-189	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
10484519-5	1999	Moreover, a posttranscriptional mechanism(s) appears to contribute significantly to COX-2 mRNA accumulation as pretreatment for 15 min with cycloheximide (CHX, 1 microM) caused a superinduction of COX-2 mRNA accumulation in unstimulated cells as well as in cells challenged with either TNF or PMA.	Cycloheximide	140-153	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-89
10484519-5	1999	Moreover, a posttranscriptional mechanism(s) appears to contribute significantly to COX-2 mRNA accumulation as pretreatment for 15 min with cycloheximide (CHX, 1 microM) caused a superinduction of COX-2 mRNA accumulation in unstimulated cells as well as in cells challenged with either TNF or PMA.	Cycloheximide	140-153	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	197-202
10484519-5	1999	Moreover, a posttranscriptional mechanism(s) appears to contribute significantly to COX-2 mRNA accumulation as pretreatment for 15 min with cycloheximide (CHX, 1 microM) caused a superinduction of COX-2 mRNA accumulation in unstimulated cells as well as in cells challenged with either TNF or PMA.	Cycloheximide	155-158	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-89
10484519-5	1999	Moreover, a posttranscriptional mechanism(s) appears to contribute significantly to COX-2 mRNA accumulation as pretreatment for 15 min with cycloheximide (CHX, 1 microM) caused a superinduction of COX-2 mRNA accumulation in unstimulated cells as well as in cells challenged with either TNF or PMA.	Cycloheximide	155-158	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	197-202
10484519-6	1999	Expression of COX-2 protein in unstimulated MTAL cells was attenuated by preincubation for 2 h with dexamethasone (Dex, 2 microM); however, Dex had little or no effect on COX-2 expression in cells challenged with either PMA or TNF.	Dexamethasone	100-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
10484519-6	1999	Expression of COX-2 protein in unstimulated MTAL cells was attenuated by preincubation for 2 h with dexamethasone (Dex, 2 microM); however, Dex had little or no effect on COX-2 expression in cells challenged with either PMA or TNF.	Dexamethasone	115-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
10484519-6	1999	Expression of COX-2 protein in unstimulated MTAL cells was attenuated by preincubation for 2 h with dexamethasone (Dex, 2 microM); however, Dex had little or no effect on COX-2 expression in cells challenged with either PMA or TNF.	Dexamethasone	140-143	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
10485483-9	1999	Treatment of BxPC-3 cells with sulindac sulfide and NS398 resulted in an induction of COX-2 expression.	sulindac sulfide	31-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-91
10485483-9	1999	Treatment of BxPC-3 cells with sulindac sulfide and NS398 resulted in an induction of COX-2 expression.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	52-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-91
10460228-2	1999	The aim of this study was to examine the expression of the two isoforms of the central prostaglandin synthetic enzyme, cyclo-oxygenase (COX-1 and COX-2) in human myometrium throughout pregnancy and to test the hypothesis that COX in the myometrium may play a role in labour onset.	Prostaglandins	87-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	146-151
10509845-3	1999	COX-1 is continuously expressed in almost all tissues, where it converts arachidonate to the prostaglandins (PGs) important in homeostatic function; COX-2 is present in immune cells, blood vessel endothelial cells, and synovial fibroblasts.	Prostaglandins	93-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	149-154
10509845-3	1999	COX-1 is continuously expressed in almost all tissues, where it converts arachidonate to the prostaglandins (PGs) important in homeostatic function; COX-2 is present in immune cells, blood vessel endothelial cells, and synovial fibroblasts.	Prostaglandins	109-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	149-154
10509845-5	1999	In theory, a drug such as celecoxib that selectively inhibited COX-2 might block inflammation, pain, and fever while reducing the side effects (gastric erosions and ulcers) associated with inhibition of COX-1.	Celecoxib	26-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-68
10509845-6	1999	In animal models of inflammation and pain, celecoxib has shown marked suppression of PG production and inflammation compared with indomethacin, the standard COX-1/COX-2 inhibitor.	Celecoxib	43-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	163-168
10460228-6	1999	These data would suggest that up-regulation of COX-2, rather than COX-1, mediates increased prostaglandin synthesis in human myometrium at term.	Prostaglandins	92-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
10460160-5	1999	This demonstrates that fluorophthalate binds to PDO with a handedness, i.e., with the fluorine label facing to the "right" or to the "left", relative to the hyperfine tensor of the Co(II).	fluorophthalate	23-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	181-187
10438452-0	1999	Arachidonic acid oxygenation by COX-1 and COX-2.	Arachidonic Acid	0-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47
10455314-9	1999	In A549 cells treated for 24 h with interleukin-1beta, to induce COX-2, A771726 potently inhibited PGE2 synthesis (IC50 0.13 microg ml-1).	Dinoprostone	99-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-70
10465547-0	1999	SAR in the alkoxy lactone series: the discovery of DFP, a potent and orally active COX-2 inhibitor.	Lactones	18-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
10465547-1	1999	Extensive SAR has been established in the alkoxy lactone series and this has lead to the discovery of DFP (5,5-dimethyl-3-(2-propoxy)-4-methanesulfonylphenyl)-2(5H)-furanon e), a potent COX-2 inhibitor exhibiting in vivo efficacy in all models studied.	alkoxy lactone	42-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	186-191
10465547-1	1999	Extensive SAR has been established in the alkoxy lactone series and this has lead to the discovery of DFP (5,5-dimethyl-3-(2-propoxy)-4-methanesulfonylphenyl)-2(5H)-furanon e), a potent COX-2 inhibitor exhibiting in vivo efficacy in all models studied.	Isoflurophate	102-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	186-191
10465547-1	1999	Extensive SAR has been established in the alkoxy lactone series and this has lead to the discovery of DFP (5,5-dimethyl-3-(2-propoxy)-4-methanesulfonylphenyl)-2(5H)-furanon e), a potent COX-2 inhibitor exhibiting in vivo efficacy in all models studied.	5,5-dimethyl-3-(2-propoxy)-4-methanesulfonylphenyl)-2(5h)-furanon e	107-174	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	186-191
10483516-9	1999	The underlying mechanism is suggested as feedback regulatory induction of COX-2 by a prostaglandin driven cAMP-mediated process.	Prostaglandins	85-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
10483516-9	1999	The underlying mechanism is suggested as feedback regulatory induction of COX-2 by a prostaglandin driven cAMP-mediated process.	Cyclic AMP	106-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
10455314-19	1999	Only at much higher drug levels does leflunomide and/or A771726 inhibit the induction of COX-2 or iNOS proteins.	a771726	56-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-94
10455314-19	1999	Only at much higher drug levels does leflunomide and/or A771726 inhibit the induction of COX-2 or iNOS proteins.	Leflunomide	37-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-94
10457118-9	1999	In contrast, in the cell-free homogenate of cultured human mast cells, EPA inhibited both COX-1 and COX-2 activities.	Eicosapentaenoic Acid	71-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-105
10457118-10	1999	CONCLUSION: Pre-incubation with EPA primarily affects the COX-2 pathway in cultured human mast cells and reduces PGD2 generation in response to IgE-anti-IgE challenge incubation.	Eicosapentaenoic Acid	32-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
10469147-5	1999	Cotransfection of sPLA2-V with cyclooxygenase (COX)-2, but not with COX-1, into human embryonic kidney 293 cells dramatically increased the interleukin-1-dependent PGE2 generation occurring over a 24 h of culture period.	Dinoprostone	164-168	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-53
10421661-5	1999	We found that, in the hepatoma cell lines, CCL13/Chang and HepG2, indomethacin, a selective cyclo-oxygenase 1 and 2 (COX-1 and COX-2) inhibitor, increases IFN-alpha stimulation of interferon-stimulated response element (ISRE)-dependent transcription in a dose-dependent manner.	Indomethacin	66-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	127-132
10489876-0	1999	Synthesis and biological acitivity of annulated pyrazoles as selective COX-2 inhibitors.	Pyrazoles	48-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-76
10489876-2	1999	A series of disubstituted 4,5-polymethylenepyrazoles were synthesized and evaluated their inhibitory activities against COX-2.	4,5-polymethylenepyrazoles	26-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-125
10411562-4	1999	Rofecoxib is a potent inhibitor of the COX-2-dependent production of PGE(2) in human osteosarcoma cells (IC(50) = 26 +/- 10 nM) and Chinese hamster ovary cells expressing human COX-2 (IC(50) = 18 +/- 7 nM) with a 1000-fold selectivity for the inhibition of COX-2 compared with the inhibition of COX-1 activity (IC(50) > 50 microM in U937 cells and IC(50) > 15 microM in Chinese hamster ovary cells expressing human COX-1).	Dinoprostone	69-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-44
10411562-2	1999	The discoveries that cyclooxygenase (COX)-2 is an inducible form of COX involved in inflammation and that COX-1 is the major isoform responsible for the production of prostaglandins (PGs) in the gastrointestinal tract have provided a rationale for the development of specific COX-2 inhibitors as a new class of anti-inflammatory agents with improved gastrointestinal tolerability.	Prostaglandins	183-186	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-43
10476899-3	1999	The purpose of the present study was to investigate the involvement of cyclooxygenase (COX)-1 and COX-2 in PGE2 production by PDL cells stimulated with a proinflammatory cytokine, interleukin-1alpha (IL-1alpha), and to examine the regulation of PGE2 production by cell-cell interaction of human gingival keratinocytes and PDL cells.	Dinoprostone	107-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-103
10476899-7	1999	Indomethacin, a non-selective COX-1/COX-2 inhibitor, and NS-398, a selective COX-2 inhibitor, completely inhibited PGE2 production by the IL-1alpha-stimulated cells.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	57-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-82
10476899-7	1999	Indomethacin, a non-selective COX-1/COX-2 inhibitor, and NS-398, a selective COX-2 inhibitor, completely inhibited PGE2 production by the IL-1alpha-stimulated cells.	Dinoprostone	115-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-82
10476899-11	1999	Treatment of IL-1alpha-stimulated PDL cells with dexamethasone, known to inhibit COX-2 expression, prevented PGE2 production and COX-2 mRNA expression.	Dexamethasone	49-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-86
10476899-11	1999	Treatment of IL-1alpha-stimulated PDL cells with dexamethasone, known to inhibit COX-2 expression, prevented PGE2 production and COX-2 mRNA expression.	Dexamethasone	49-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-134
10476899-11	1999	Treatment of IL-1alpha-stimulated PDL cells with dexamethasone, known to inhibit COX-2 expression, prevented PGE2 production and COX-2 mRNA expression.	Dinoprostone	109-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-86
10476899-15	1999	CONCLUSIONS: We suggest that PDL cells stimulated with IL-1alpha produce PGE2 through de novo synthesis of COX-2 and that the cell interaction of gingival keratinocytes and PDL cells controls COX-2 expression and PGE2 production via IL-1alpha or 1alpha IL-la-like factor(s).	Dinoprostone	73-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-112
10449029-9	1999	The dramatic protective effects of celecoxib suggests that specific COX-2 inhibitors may offer a way to safely reduce the risk of skin cancer in humans.	Celecoxib	35-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-73
10411562-2	1999	The discoveries that cyclooxygenase (COX)-2 is an inducible form of COX involved in inflammation and that COX-1 is the major isoform responsible for the production of prostaglandins (PGs) in the gastrointestinal tract have provided a rationale for the development of specific COX-2 inhibitors as a new class of anti-inflammatory agents with improved gastrointestinal tolerability.	Prostaglandins	183-186	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	276-281
10411562-3	1999	In the present study, the preclinical pharmacological and biochemical profiles of rofecoxib [Vioxx, also known as MK-0966, 4-(4"-methylsulfonylphenyl)-3-phenyl-2-(5H)-furanone], an orally active COX-2 inhibitor, are described.	rofecoxib	93-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	195-200
10411562-4	1999	Rofecoxib is a potent inhibitor of the COX-2-dependent production of PGE(2) in human osteosarcoma cells (IC(50) = 26 +/- 10 nM) and Chinese hamster ovary cells expressing human COX-2 (IC(50) = 18 +/- 7 nM) with a 1000-fold selectivity for the inhibition of COX-2 compared with the inhibition of COX-1 activity (IC(50) > 50 microM in U937 cells and IC(50) > 15 microM in Chinese hamster ovary cells expressing human COX-1).	rofecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-44
10411562-4	1999	Rofecoxib is a potent inhibitor of the COX-2-dependent production of PGE(2) in human osteosarcoma cells (IC(50) = 26 +/- 10 nM) and Chinese hamster ovary cells expressing human COX-2 (IC(50) = 18 +/- 7 nM) with a 1000-fold selectivity for the inhibition of COX-2 compared with the inhibition of COX-1 activity (IC(50) > 50 microM in U937 cells and IC(50) > 15 microM in Chinese hamster ovary cells expressing human COX-1).	rofecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	177-182
10411562-4	1999	Rofecoxib is a potent inhibitor of the COX-2-dependent production of PGE(2) in human osteosarcoma cells (IC(50) = 26 +/- 10 nM) and Chinese hamster ovary cells expressing human COX-2 (IC(50) = 18 +/- 7 nM) with a 1000-fold selectivity for the inhibition of COX-2 compared with the inhibition of COX-1 activity (IC(50) > 50 microM in U937 cells and IC(50) > 15 microM in Chinese hamster ovary cells expressing human COX-1).	rofecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	177-182
10411562-5	1999	Rofecoxib is a time-dependent inhibitor of purified human recombinant COX-2 (IC(50) = 0.34 microM) but caused inhibition of purified human COX-1 in a non-time-dependent manner that could only be observed at a very low substrate concentration (IC(50) = 26 microM at 0.1 microM arachidonic acid concentration).	rofecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-75
10411562-6	1999	In an in vitro human whole blood assay, rofecoxib selectively inhibited lipopolysaccharide-induced, COX-2-derived PGE(2) synthesis with an IC(50) value of 0.53 +/- 0.02 microM compared with an IC(50) value of 18.8 +/- 0.9 microM for the inhibition of COX-1-derived thromboxane B(2) synthesis after blood coagulation.	rofecoxib	40-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-105
10411562-6	1999	In an in vitro human whole blood assay, rofecoxib selectively inhibited lipopolysaccharide-induced, COX-2-derived PGE(2) synthesis with an IC(50) value of 0.53 +/- 0.02 microM compared with an IC(50) value of 18.8 +/- 0.9 microM for the inhibition of COX-1-derived thromboxane B(2) synthesis after blood coagulation.	Prostaglandins E	114-117	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-105
10411562-6	1999	In an in vitro human whole blood assay, rofecoxib selectively inhibited lipopolysaccharide-induced, COX-2-derived PGE(2) synthesis with an IC(50) value of 0.53 +/- 0.02 microM compared with an IC(50) value of 18.8 +/- 0.9 microM for the inhibition of COX-1-derived thromboxane B(2) synthesis after blood coagulation.	thromboxane b	265-278	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-105
10411562-11	1999	Rofecoxib is a novel COX-2 inhibitor with a biochemical and pharmacological profile clearly distinct from that of current nonsteroidal anti-inflammatory drugs and represents a new therapeutic class of anti-inflammatory agents for the treatment of the symptoms of osteoarthritis and rheumatoid arthritis with improved gastrointestinal tolerability.	rofecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-26
10395693-5	1999	Macrophages exposed to LPS showed a rapid and sustained expression of COX-2 mRNA and protein for up to 48 h, whereas PGE2 production was notably enhanced only after 12 h. LPS increased COX-2 gene transcription and activation of the transcription factor NF-kappa B in a transient manner.	Dinoprostone	117-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	185-190
10480184-6	1999	It was hypothesized that the constitutively expressed COX-1 isoenzyme leads to the synthesis of prostaglandins with homeostatic functions whereas COX-2 is merely responsible for the production of prostaglandins mediating pain, fever and inflammation.	Prostaglandins	196-210	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	146-151
10480184-9	1999	There is some evidence that both COX-1 and COX-2 isoforms are involved in the production of prostaglandins associated with inflammation and homeostatic functions.	Prostaglandins	92-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
10395693-9	1999	Only when LPS or IL-1 beta was removed did COX-2 mRNA decay with a t1/2 of >/=5 h. In contrast, dexamethasone promoted a faster decay of the LPS-induced COX-2 transcripts (t1/2 = 2.5 h).	Dexamethasone	99-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	156-161
10406640-1	1999	The development of a COX-2 inhibitor rofecoxib (MK 966, Vioxx) is described.	rofecoxib	37-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-26
18967665-5	1999	It was shown that ligand substitution kinetic methods coupled to three-way chemometric analytical methods can be used for the development of robust sensors for the analysis of binary [Zn(II)+Ni(II), Pb(II)+Cd(II), Zn(II)+Pb(II)] or ternary [Zn(II)+Pb(II)+Co(II)] mixtures of metal ions in the micromolar concentration range.	Zinc	184-190	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	255-261
18967665-5	1999	It was shown that ligand substitution kinetic methods coupled to three-way chemometric analytical methods can be used for the development of robust sensors for the analysis of binary [Zn(II)+Ni(II), Pb(II)+Cd(II), Zn(II)+Pb(II)] or ternary [Zn(II)+Pb(II)+Co(II)] mixtures of metal ions in the micromolar concentration range.	Nickel(2+)	191-197	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	255-261
18967665-5	1999	It was shown that ligand substitution kinetic methods coupled to three-way chemometric analytical methods can be used for the development of robust sensors for the analysis of binary [Zn(II)+Ni(II), Pb(II)+Cd(II), Zn(II)+Pb(II)] or ternary [Zn(II)+Pb(II)+Co(II)] mixtures of metal ions in the micromolar concentration range.	zn(ii)+pb(ii)	214-227	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	255-261
10406640-1	1999	The development of a COX-2 inhibitor rofecoxib (MK 966, Vioxx) is described.	rofecoxib	48-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-26
10406640-1	1999	The development of a COX-2 inhibitor rofecoxib (MK 966, Vioxx) is described.	rofecoxib	56-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-26
16127636-2	1999	The introduction of celecoxib (Celebrex, Figure 1; GD Searle and Co) as the first cyclooxygenase (COX)2 selective inhibitor in the US and the expected introduction of rofecoxib (Vioxx; Merck and Co Inc) as the first COX2 inhibitor with an acute pain indication, has prompted interest in this class of drugs as a possible therapeutic improvement on dual COX1/COX2 inhibitor NSAIDs, currently on the market.	Celecoxib	20-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-103
10383598-8	1999	Pretreatment with dexamethasone abolished IL-1beta- and BK-stimulated COX-2 induction in all cells studied.	Dexamethasone	18-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-75
10383598-10	1999	Both IL-1beta and BK induced COX-2 expression in all cells studied and this induction was blocked by dexamethasone.	Dexamethasone	101-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34
10390414-3	1999	To increase the production of the potentially protective endogenous PGE2, COX-2 should be upregulated.	Dinoprostone	68-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
10390414-4	1999	We hypothesize that an abnormal regulation of COX-2 will predispose patients with asthma to develop aspirin-intolerant asthma/rhinitis (AIAR).	Aspirin	100-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
10397690-10	1999	Lysophosphatidylcholine, 7beta-hydroxycholesterol, and 7-oxocholesterol failed to mimic the inhibition, but oxidized arachidonic acid-containing phospholipids, produced by autoxidation of 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine, markedly inhibited Cox-2.	Phospholipids	145-158	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	263-268
10463513-5	1999	Preliminary data suggest that celecoxib, a highly selective COX-2 inhibitor, is superior to placebo and similar to traditional NSAIDs in the short-term treatment of pain due to osteoarthritis, although it has been associated with adverse effects such as headache, change in bowel habits, abdominal discomfort, and dizziness.	Celecoxib	30-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-65
16127636-2	1999	The introduction of celecoxib (Celebrex, Figure 1; GD Searle and Co) as the first cyclooxygenase (COX)2 selective inhibitor in the US and the expected introduction of rofecoxib (Vioxx; Merck and Co Inc) as the first COX2 inhibitor with an acute pain indication, has prompted interest in this class of drugs as a possible therapeutic improvement on dual COX1/COX2 inhibitor NSAIDs, currently on the market.	Celecoxib	20-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	216-220
10450786-1	1999	OBJECTIVE: To investigate anti-inflammatory effects of lornoxicam in vitro on COX-1/COX-2, on NO formation from iNOS and on the formation of the pro-inflammatory cytokines TNF-alpha, IL-1beta, IL-6, and IL-8.	lornoxicam	55-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-89
16127636-2	1999	The introduction of celecoxib (Celebrex, Figure 1; GD Searle and Co) as the first cyclooxygenase (COX)2 selective inhibitor in the US and the expected introduction of rofecoxib (Vioxx; Merck and Co Inc) as the first COX2 inhibitor with an acute pain indication, has prompted interest in this class of drugs as a possible therapeutic improvement on dual COX1/COX2 inhibitor NSAIDs, currently on the market.	Celecoxib	20-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	358-362
16127636-2	1999	The introduction of celecoxib (Celebrex, Figure 1; GD Searle and Co) as the first cyclooxygenase (COX)2 selective inhibitor in the US and the expected introduction of rofecoxib (Vioxx; Merck and Co Inc) as the first COX2 inhibitor with an acute pain indication, has prompted interest in this class of drugs as a possible therapeutic improvement on dual COX1/COX2 inhibitor NSAIDs, currently on the market.	Celecoxib	31-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-103
10414247-5	1999	CLINICAL RESULTS: Celecoxib and rofecoxib are two COX-2 specific inhibitors.	Celecoxib	18-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-55
10384106-1	1999	Cyclooxygenase (COX), known to exist in two isoforms, COX-1 and COX-2, is a key enzyme in prostaglandin synthesis and the target for most nonsteroidal anti-inflammatory drugs.	Prostaglandins	90-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-69
10384106-4	1999	COX-2 mRNA was induced very early after activation and superinduced by protein synthesis inhibitors, whereas it was inhibited by the immunosuppressive drug cyclosporin A, identifying it as an early T cell activation gene.	Cyclosporine	156-169	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
10384106-5	1999	Interestingly, treatment with COX-2-specific inhibitors such as NS398 or Celecoxib severely diminished early and late events of T cell activation, including CD25 and CD71 cell surface expression, IL-2, TNF-alpha, and IFN-gamma production and cell proliferation, but not the expression of CD69, an immediate early gene.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	64-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-35
10384106-5	1999	Interestingly, treatment with COX-2-specific inhibitors such as NS398 or Celecoxib severely diminished early and late events of T cell activation, including CD25 and CD71 cell surface expression, IL-2, TNF-alpha, and IFN-gamma production and cell proliferation, but not the expression of CD69, an immediate early gene.	Celecoxib	73-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-35
10381787-1	1999	We evaluated whether therapeutic blood levels of meloxicam are associated with selective inhibition of monocyte cyclooxygenase (COX)-2 in vitro and ex vivo.	Meloxicam	49-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-134
10381787-2	1999	Concentration-response curves for the inhibition of monocyte COX-2 and platelet COX-1 were obtained in vitro after the incubation of meloxicam with whole blood samples.	Meloxicam	133-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-66
10419782-8	1999	In-vitro, COX-2 expression in synovial cells is dramatically increased by proinflammatory cytokines, phorbol ester, and stimulation of certain cell surface receptors.	Phorbol Esters	101-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
10419782-11	1999	Taken together, these data suggest that COX-2 is likely to be responsible for increased local PG production during inflammation of synovial tissues.	Prostaglandins	94-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
10419786-4	1999	Endogenous PGs in bone are produced largely by induction of COX-2, which is highly regulated by hormones and local factors.	Prostaglandins	11-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-65
10419786-5	1999	The development of specific agonists and antagonists for PG receptors and for COX-2 should allow us to define the physiologic and pathophysiologic roles of PGs more precisely and develop new therapeutic approaches to metabolic and inflammatory disorders of the skeleton.	Prostaglandins	156-159	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-83
10419787-5	1999	There is a later phase of indomethacin-sensitivity associated with COX-2 expression in bone at 6h.	Indomethacin	26-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-72
18967634-1	1999	The partial least squares modeling based on singular value decomposition was applied for the simultaneous spectrophotometric determination of Co(II), Ni(II) and Cu(II) as their ammonium 2-amino-1-cyclohexan-1-dithiocarbamate complexes.	cu(ii)	161-167	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	142-148
18967634-1	1999	The partial least squares modeling based on singular value decomposition was applied for the simultaneous spectrophotometric determination of Co(II), Ni(II) and Cu(II) as their ammonium 2-amino-1-cyclohexan-1-dithiocarbamate complexes.	ammonium 2-amino-1-cyclohexan-1-dithiocarbamate	177-224	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	142-148
10381787-8	1999	In contrast, the administration of 7.5 and 15 mg of meloxicam caused dose-dependent reductions in monocyte COX-2 activity by 51% and 70%, respectively, and in platelet COX-1 activity by 25% and 35%, respectively.	Meloxicam	52-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-112
10419773-1	1999	The development of selective COX-2 inhibitors has renewed interest in the treatment of osteoarthritis with prostaglandin synthesis inhibitors.	Prostaglandins	107-120	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34
10377455-5	1999	These comparisons of the actions of >40 NSAIDs and novel COX-2-selective agents, including celecoxib, rofecoxib and diisopropyl fluorophosphate, demonstrate a distribution of compound selectivities toward COX-1 that aligns with the risk of serious gastrointestinal complications.	Celecoxib	94-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-65
10377455-5	1999	These comparisons of the actions of >40 NSAIDs and novel COX-2-selective agents, including celecoxib, rofecoxib and diisopropyl fluorophosphate, demonstrate a distribution of compound selectivities toward COX-1 that aligns with the risk of serious gastrointestinal complications.	rofecoxib	105-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-65
10377455-5	1999	These comparisons of the actions of >40 NSAIDs and novel COX-2-selective agents, including celecoxib, rofecoxib and diisopropyl fluorophosphate, demonstrate a distribution of compound selectivities toward COX-1 that aligns with the risk of serious gastrointestinal complications.	Isoflurophate	119-146	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-65
10414247-5	1999	CLINICAL RESULTS: Celecoxib and rofecoxib are two COX-2 specific inhibitors.	rofecoxib	32-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-55
10383505-1	1999	BACKGROUND: Compared with currently available NSAIDs (which inhibit COX-1 and COX-2 isoforms of cyclooxygenase), MK-0966 (a specific COX-2 inhibitor) is expected to cause less gastrointestinal toxicity.	rofecoxib	113-120	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	133-138
10391671-2	1999	Nonsteroidal antiinflammatory drugs (NSAIDs) such as ibuprofen and diclofenac inhibit both COX-1 and COX-2.	Ibuprofen	53-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-106
10391671-2	1999	Nonsteroidal antiinflammatory drugs (NSAIDs) such as ibuprofen and diclofenac inhibit both COX-1 and COX-2.	Diclofenac	67-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-106
10391671-3	1999	The role of COX-2 in the genesis of fever in monkeys and humans was examined with use of the specific COX-2 inhibitor rofecoxib.	rofecoxib	118-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-107
10391671-10	1999	Specific inhibition of COX-2 by rofecoxib results in antipyretic activity in monkeys and humans comparable to dual COX-1/COX-2 inhibitors such as diclofenac or ibuprofen.	rofecoxib	32-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-28
10390126-6	1999	In contrast, COX-2, the inducible form, is expressed in response to inflammatory and other physiologic stimuli and growth factors and is involved in the production of those prostaglandins that mediate pain and support the inflammatory process.	Prostaglandins	173-187	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
10440619-7	1999	We concluded that rofecoxib was efficacious in the treatment of postoperative dental pain and that COX-2-derived prostanoids play a role in treatment of the pain associated with dental surgery.	Prostaglandins	113-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-104
15819041-1	1999	Direct interaction of Cu2Zn2SOD with inorganic metal compound (CoCl2) and organic metal compound [Co(II)(His)n] was studied by ICP, VIS, NMR and measurement of enzyme activity.	cu2zn2sod	22-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-104
15819041-1	1999	Direct interaction of Cu2Zn2SOD with inorganic metal compound (CoCl2) and organic metal compound [Co(II)(His)n] was studied by ICP, VIS, NMR and measurement of enzyme activity.	Metals	82-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-104
15819041-4	1999	Moreover, the interaction of Co(II)(His)n with Cu2Zn2SOD is stronger and quicker, than that of CoCl2 with this enzyme, as well as the Co(II) from Co(II)(His)n is easier to enter the active center of enzyme.	his)n	36-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-35
15819041-4	1999	Moreover, the interaction of Co(II)(His)n with Cu2Zn2SOD is stronger and quicker, than that of CoCl2 with this enzyme, as well as the Co(II) from Co(II)(His)n is easier to enter the active center of enzyme.	his)n	36-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-140
15819041-4	1999	Moreover, the interaction of Co(II)(His)n with Cu2Zn2SOD is stronger and quicker, than that of CoCl2 with this enzyme, as well as the Co(II) from Co(II)(His)n is easier to enter the active center of enzyme.	his)n	36-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-140
15819041-4	1999	Moreover, the interaction of Co(II)(His)n with Cu2Zn2SOD is stronger and quicker, than that of CoCl2 with this enzyme, as well as the Co(II) from Co(II)(His)n is easier to enter the active center of enzyme.	cu2zn2sod	47-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-35
15819041-4	1999	Moreover, the interaction of Co(II)(His)n with Cu2Zn2SOD is stronger and quicker, than that of CoCl2 with this enzyme, as well as the Co(II) from Co(II)(His)n is easier to enter the active center of enzyme.	cu2zn2sod	47-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-140
15819041-4	1999	Moreover, the interaction of Co(II)(His)n with Cu2Zn2SOD is stronger and quicker, than that of CoCl2 with this enzyme, as well as the Co(II) from Co(II)(His)n is easier to enter the active center of enzyme.	cu2zn2sod	47-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-140
15819041-4	1999	Moreover, the interaction of Co(II)(His)n with Cu2Zn2SOD is stronger and quicker, than that of CoCl2 with this enzyme, as well as the Co(II) from Co(II)(His)n is easier to enter the active center of enzyme.	cobaltous chloride	95-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-35
15819041-4	1999	Moreover, the interaction of Co(II)(His)n with Cu2Zn2SOD is stronger and quicker, than that of CoCl2 with this enzyme, as well as the Co(II) from Co(II)(His)n is easier to enter the active center of enzyme.	cobaltous chloride	95-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-140
15819041-4	1999	Moreover, the interaction of Co(II)(His)n with Cu2Zn2SOD is stronger and quicker, than that of CoCl2 with this enzyme, as well as the Co(II) from Co(II)(His)n is easier to enter the active center of enzyme.	cobaltous chloride	95-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-140
15819047-1	1999	Three new solid complexes of transition metal Co(II), Ni(II) and Cu(II) with quinoxaline-2,3-dicarboxamide were synthesized, and the composition of the complexes was confirmed to be M(Qxda)2Cl2 [M = Co(II), Ni(II), Cu(II)] by elemental analysis, molar conductance and thermal analysis.	Metals	40-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-52
15819047-1	1999	Three new solid complexes of transition metal Co(II), Ni(II) and Cu(II) with quinoxaline-2,3-dicarboxamide were synthesized, and the composition of the complexes was confirmed to be M(Qxda)2Cl2 [M = Co(II), Ni(II), Cu(II)] by elemental analysis, molar conductance and thermal analysis.	cu(ii)	65-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	199-205
15819047-1	1999	Three new solid complexes of transition metal Co(II), Ni(II) and Cu(II) with quinoxaline-2,3-dicarboxamide were synthesized, and the composition of the complexes was confirmed to be M(Qxda)2Cl2 [M = Co(II), Ni(II), Cu(II)] by elemental analysis, molar conductance and thermal analysis.	quinoxaline-2,3-dicarboxamide	77-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-52
15819047-1	1999	Three new solid complexes of transition metal Co(II), Ni(II) and Cu(II) with quinoxaline-2,3-dicarboxamide were synthesized, and the composition of the complexes was confirmed to be M(Qxda)2Cl2 [M = Co(II), Ni(II), Cu(II)] by elemental analysis, molar conductance and thermal analysis.	(qxda)2cl2	183-193	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-52
10381057-8	1999	Dexamethasone inhibited COX-2 mRNA expression induced by IL-1.	Dexamethasone	0-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
10381057-10	1999	Dexamethasone was the strongest drug inhibitor of COX-2 (IC50 = 0.0073 microM).	Dexamethasone	0-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-55
10381057-13	1999	Indomethacin and diclofenac were the most potent inhibitors of COX-1 (IC50 = 0.063 microM and 0.611 microM, respectively) and COX-2 isoforms (IC50 = 0.48 microM and IC50 = 0.63 microM, respectively).	Indomethacin	0-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-131
10381057-13	1999	Indomethacin and diclofenac were the most potent inhibitors of COX-1 (IC50 = 0.063 microM and 0.611 microM, respectively) and COX-2 isoforms (IC50 = 0.48 microM and IC50 = 0.63 microM, respectively).	Diclofenac	17-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-131
10381057-14	1999	Meloxicam was a more potent inhibitor of COX-2 (IC50 = 4.7 microM) than aspirin (IC50 = 29.3 microM) and similar to piroxicam (IC50 = 4.4 microM).	Meloxicam	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-46
10381057-15	1999	Among all drugs tested dexamethasone showed the greatest selectivity for COX-2 and meloxicam was the NSAID with the best COX-2/COX-1 ratio (r = 0.12).	Dexamethasone	23-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-78
10381057-15	1999	Among all drugs tested dexamethasone showed the greatest selectivity for COX-2 and meloxicam was the NSAID with the best COX-2/COX-1 ratio (r = 0.12).	Dexamethasone	23-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-126
10381057-15	1999	Among all drugs tested dexamethasone showed the greatest selectivity for COX-2 and meloxicam was the NSAID with the best COX-2/COX-1 ratio (r = 0.12).	Meloxicam	83-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-126
10381057-16	1999	Aspirin and piroxicam were about 8 times more active against COX-1 than COX-2, indomethacin was 7 times more active, and diclofenac was an equipotent inhibitor of COX-1 and COX-2.	Aspirin	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
10381057-16	1999	Aspirin and piroxicam were about 8 times more active against COX-1 than COX-2, indomethacin was 7 times more active, and diclofenac was an equipotent inhibitor of COX-1 and COX-2.	Aspirin	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	173-178
10381057-16	1999	Aspirin and piroxicam were about 8 times more active against COX-1 than COX-2, indomethacin was 7 times more active, and diclofenac was an equipotent inhibitor of COX-1 and COX-2.	Piroxicam	12-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
10381057-16	1999	Aspirin and piroxicam were about 8 times more active against COX-1 than COX-2, indomethacin was 7 times more active, and diclofenac was an equipotent inhibitor of COX-1 and COX-2.	Piroxicam	12-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	173-178
10381057-16	1999	Aspirin and piroxicam were about 8 times more active against COX-1 than COX-2, indomethacin was 7 times more active, and diclofenac was an equipotent inhibitor of COX-1 and COX-2.	Diclofenac	121-131	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	173-178
10390127-4	1999	The recent development of COX-2-specific inhibitors, such as celecoxib, raises the possibility of relieving pain and inflammation with reduced risk of gastrointestinal complications.	Celecoxib	61-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-31
10229670-4	1999	PGE generation by goldfish macrophages was similarly inhibited by the glucocorticoid, dexamethasone, and an inhibitor of protein synthesis, cycloheximide, suggesting that this stimulation may be due to an inducible enzyme equivalent to mammalian COX-2.	Prostaglandins E	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	246-251
10229670-4	1999	PGE generation by goldfish macrophages was similarly inhibited by the glucocorticoid, dexamethasone, and an inhibitor of protein synthesis, cycloheximide, suggesting that this stimulation may be due to an inducible enzyme equivalent to mammalian COX-2.	Dexamethasone	86-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	246-251
10229670-4	1999	PGE generation by goldfish macrophages was similarly inhibited by the glucocorticoid, dexamethasone, and an inhibitor of protein synthesis, cycloheximide, suggesting that this stimulation may be due to an inducible enzyme equivalent to mammalian COX-2.	Cycloheximide	140-153	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	246-251
10215599-2	1999	The discovery of a second COX isoform (COX-2) associated with inflammation led to agents that selectively inhibit COX-2, e.g. celecoxib.	Celecoxib	126-135	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-44
10344742-4	1999	CAPE nonselectively inhibited the activities of baculovirus-expressed hCOX-1 and hCOX-2 enzymes.	caffeic acid phenethyl ester	0-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-87
10344742-6	1999	Higher concentrations of CAPE (10-20 microg/ml) suppressed the induction of COX-2 mRNA and protein mediated by TPA.	caffeic acid phenethyl ester	25-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-81
10344742-6	1999	Higher concentrations of CAPE (10-20 microg/ml) suppressed the induction of COX-2 mRNA and protein mediated by TPA.	Tetradecanoylphorbol Acetate	111-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-81
10344742-7	1999	Transient transfections using human COX-2 promoter deletion constructs were performed; the effects of TPA and CAPE were localized to a 124-bp region of the COX-2 promoter.	caffeic acid phenethyl ester	110-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	156-161
10344742-9	1999	Amounts of COX-2 in the pouch were markedly suppressed by 100 mg/kg CAPE but were unaffected by indomethacin.	caffeic acid phenethyl ester	68-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-16
10215599-2	1999	The discovery of a second COX isoform (COX-2) associated with inflammation led to agents that selectively inhibit COX-2, e.g. celecoxib.	Celecoxib	126-135	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-119
10215599-5	1999	An initial competitive interaction with COX-2 can also be discerned with celecoxib (Ki=11-15 microM), followed by a time-dependent interaction leading to potent inhibition, characterized as inactivation (Kinact=0.03-0.5 s-1).	Celecoxib	73-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
10215647-2	1999	The present study was undertaken to assess the renal effects of the specific Cox-2 inhibitor, MK-966.	rofecoxib	94-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-82
10391112-4	1999	Finally, the latest published clinical data of new selective and highly selective inhibitors of COX-2 (meloxicam, nimesulide, etodolac, celecoxib and MK966) are discussed.	Meloxicam	103-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-101
10391112-4	1999	Finally, the latest published clinical data of new selective and highly selective inhibitors of COX-2 (meloxicam, nimesulide, etodolac, celecoxib and MK966) are discussed.	nimesulide	114-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-101
10391112-4	1999	Finally, the latest published clinical data of new selective and highly selective inhibitors of COX-2 (meloxicam, nimesulide, etodolac, celecoxib and MK966) are discussed.	Etodolac	126-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-101
10391112-4	1999	Finally, the latest published clinical data of new selective and highly selective inhibitors of COX-2 (meloxicam, nimesulide, etodolac, celecoxib and MK966) are discussed.	Celecoxib	136-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-101
10391112-4	1999	Finally, the latest published clinical data of new selective and highly selective inhibitors of COX-2 (meloxicam, nimesulide, etodolac, celecoxib and MK966) are discussed.	rofecoxib	150-155	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-101
10198120-6	1999	The gene arrangement, COII-tRNALys-ATP8-ATP6, is observed in many Eumetazoan phyla and is apparently ancestral in the metazoa.	eumetazoan	66-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-26
10340919-1	1999	OBJECTIVE: To evaluate the extent of human cyclooxygenase-1 (COX-1) inhibition by meloxicam, which has been reported to preferentially inhibit cyclooxygenase-2 (COX-2).	Meloxicam	82-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	161-166
10215647-11	1999	Cox-2 may play a role in the systemic biosynthesis of prostacyclin in healthy humans.	Epoprostenol	54-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
10215647-12	1999	Selective inhibition of Cox-2 by MK-966 caused a clinically insignificant and transient retention of sodium, but no depression of GFR.	rofecoxib	33-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
10215647-12	1999	Selective inhibition of Cox-2 by MK-966 caused a clinically insignificant and transient retention of sodium, but no depression of GFR.	Sodium	101-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
10215647-14	1999	Our data suggest that acute sodium retention by nonsteroidal anti-inflammatory drugs in healthy elderly subjects is mediated by the inhibition of Cox-2, whereas depression of GFR is due to inhibition of Cox-1.	Sodium	28-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	146-151
10338371-6	1999	These data indicate that the increased fetal membrane prostaglandin production in response to CRH or PAF may involve the induction of COX-2.	Prostaglandins	54-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-139
10431478-0	1999	Effects of nimesulide and indometacin on COX-1 and COX-2: a comparative study.	nimesulide	11-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-56
10431478-0	1999	Effects of nimesulide and indometacin on COX-1 and COX-2: a comparative study.	Indomethacin	26-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-56
11670936-4	1999	2.5 A, Co-N(imidazole) axial bond, at least in the enzyme"s crystallographically characterized Co(II)/Co(III) state and conformation.	co-n(imidazole)	7-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-101
10356423-3	1999	The preliminary in vivo experience with COX-2-selective inhibitors has provided evidence for proof of concept for the COX-1 and COX-2 hypothesis, namely that the selective inhibition of COX-2-derived prostaglandins is sufficient to inhibit inflammation and is nonulcerogenic.	Prostaglandins	200-214	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
10356423-3	1999	The preliminary in vivo experience with COX-2-selective inhibitors has provided evidence for proof of concept for the COX-1 and COX-2 hypothesis, namely that the selective inhibition of COX-2-derived prostaglandins is sufficient to inhibit inflammation and is nonulcerogenic.	Prostaglandins	200-214	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	128-133
10356423-3	1999	The preliminary in vivo experience with COX-2-selective inhibitors has provided evidence for proof of concept for the COX-1 and COX-2 hypothesis, namely that the selective inhibition of COX-2-derived prostaglandins is sufficient to inhibit inflammation and is nonulcerogenic.	Prostaglandins	200-214	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	128-133
10220459-2	1999	In this report, the effects of aspirin and sodium salicylate on COX-2 expressions in human umbilical vein endothelial cells and foreskin fibroblasts were evaluated.	Aspirin	31-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-69
10216286-11	1999	A COX inhibitor, indomethacin, suppressed the stimulated growth, increased DNA synthesis and induction of epidermal growth factor receptor in COX-1- and COX-2-transfected cells.	Indomethacin	17-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	153-158
10328306-1	1999	A series of novel sulfone substituted 4,5-diarylthiazoles have been synthesized and evaluated for their inhibition of the two isoforms of human cyclooxygenase (COX-1 and COX-2).	Sulfones	18-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	170-175
10328306-1	1999	A series of novel sulfone substituted 4,5-diarylthiazoles have been synthesized and evaluated for their inhibition of the two isoforms of human cyclooxygenase (COX-1 and COX-2).	4,5-diarylthiazoles	38-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	170-175
10328307-1	1999	A series of sulfonamide-substituted 4,5-diarylthiazoles was prepared via three synthetic routes as selective COX-2 inhibitors.	sulfonamide-substituted 4,5-diarylthiazoles	12-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-114
10328307-2	1999	Recently in the synthesis of selective COX-2 inhibitors we have discovered that the sulfonamide moiety is a suitable replacement for the methylsulfonyl moiety yielding compounds with activity both in vitro and in vivo.	Sulfonamides	84-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-44
10369404-2	1999	The abilities of nimesulide to inhibit COX-2 preferentially and to exert other novel anti-inflammatory actions are consistent with good efficacy and safety.	nimesulide	17-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-44
10220459-2	1999	In this report, the effects of aspirin and sodium salicylate on COX-2 expressions in human umbilical vein endothelial cells and foreskin fibroblasts were evaluated.	Sodium Salicylate	43-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-69
10220459-3	1999	Aspirin and sodium salicylate at therapeutic concentrations equipotently blocked COX-2 mRNA and protein levels induced by interleukin-1beta and phorbol 12-myristate 13-acetate.	Sodium Salicylate	12-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-86
10220459-3	1999	Aspirin and sodium salicylate at therapeutic concentrations equipotently blocked COX-2 mRNA and protein levels induced by interleukin-1beta and phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	144-175	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-86
10220459-5	1999	Salicylate inhibited nascent COX-2 transcript synthesis but had no effect on COX-2 mRNA stability.	Salicylates	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34
10220459-8	1999	These findings suggest that salicylate exerts its antiinflammatory action in part by suppressing COX-2 induction, thereby reducing the synthesis of proinflammatory prostaglandins.	Salicylates	28-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
10328307-2	1999	Recently in the synthesis of selective COX-2 inhibitors we have discovered that the sulfonamide moiety is a suitable replacement for the methylsulfonyl moiety yielding compounds with activity both in vitro and in vivo.	methylsulfonyl	137-151	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-44
10198245-6	1999	Furthermore, the COX-2 specific inhibitor, NS-398, abolished the PGE2 production induced by IL-1beta, EGF, or the combination.	Dinoprostone	65-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22
10198245-5	1999	The tyrosine kinase inhibitors, Herbimycin A and PD 153035 hydrochloride, reduced COX-2 mRNA levels as well as PGE2 production induced by IL-1beta or the combination of IL-1beta and EGF whereas COX-1 mRNA levels were not affected.	herbimycin	32-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
10198245-7	1999	These results indicate that the synergy between IL-1beta and EGF on PGE2 production is due to an enhanced gene expression of COX-2 and that tyrosine kinase(s) are involved in the signal transduction of COX-2 in gingival fibroblasts.	Dinoprostone	68-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-130
10198245-6	1999	Furthermore, the COX-2 specific inhibitor, NS-398, abolished the PGE2 production induced by IL-1beta, EGF, or the combination.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	43-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22
10198245-7	1999	These results indicate that the synergy between IL-1beta and EGF on PGE2 production is due to an enhanced gene expression of COX-2 and that tyrosine kinase(s) are involved in the signal transduction of COX-2 in gingival fibroblasts.	Dinoprostone	68-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	202-207
10197960-5	1999	Initial mass screening and subsequent SAR studies have identified 6b (PD164387) as a potent, selective, and orally active COX-2 inhibitor.	PD 164387	70-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-127
10364907-1	1999	OBJECTIVE: To test the hypothesis that nabumetone (a partially selective cyclooxygenase-(COX)-2 inhibitor) has less effect on platelet aggregation than naproxen (a non-selective COX-inhibitor) in patients with rheumatoid arthritis (RA).	Nabumetone	39-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-95
10387389-0	1999	Celecoxib: a COX-2 inhibitor.	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
10199864-0	1999	COX-2 and cytosolic PLA2 mediate IL-1beta-induced cAMP production in human vascular smooth muscle cells.	Cyclic AMP	50-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
10199864-8	1999	A selective COX-2 inhibitor, NS-398, reversed IL-1-induced PGI2 and cAMP production, supporting a role of COX-2 in mediating increased PG synthesis.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	29-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-17
10199864-8	1999	A selective COX-2 inhibitor, NS-398, reversed IL-1-induced PGI2 and cAMP production, supporting a role of COX-2 in mediating increased PG synthesis.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	29-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-111
10199864-8	1999	A selective COX-2 inhibitor, NS-398, reversed IL-1-induced PGI2 and cAMP production, supporting a role of COX-2 in mediating increased PG synthesis.	Epoprostenol	59-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-17
10194515-2	1999	We have studied the expression of the two isoforms of the central prostaglandin synthetic enzyme, cyclo-oxygenase (COX-1 and COX-2), in human fetal membranes throughout pregnancy, at mRNA, protein and activity levels.	Prostaglandins	66-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-130
10199864-8	1999	A selective COX-2 inhibitor, NS-398, reversed IL-1-induced PGI2 and cAMP production, supporting a role of COX-2 in mediating increased PG synthesis.	Cyclic AMP	68-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-17
10199864-8	1999	A selective COX-2 inhibitor, NS-398, reversed IL-1-induced PGI2 and cAMP production, supporting a role of COX-2 in mediating increased PG synthesis.	pg	59-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-17
10199864-10	1999	The delayed induction of cPLA2 mRNA was also attenuated by NS-398, suggesting that it was secondary to the initial COX-2-induced PG synthesis.	pg	129-131	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-120
10199864-11	1999	Together, the results support the hypothesis that IL-1 induces intracellular PG synthesis in HVSMC via rapid upregulation of COX-2, which utilizes cPLA2-derived arachidonic acid to generate PG metabolites that regulate adenylate cyclase.	pg	77-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-130
10199864-11	1999	Together, the results support the hypothesis that IL-1 induces intracellular PG synthesis in HVSMC via rapid upregulation of COX-2, which utilizes cPLA2-derived arachidonic acid to generate PG metabolites that regulate adenylate cyclase.	pg	190-192	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-130
10194515-7	1999	These data suggest that it is up-regulation of COX-2, rather than of COX-1, which mediates increased prostaglandin synthesis within the fetal membranes at term.	Prostaglandins	101-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
12973428-5	1999	The reason for this was resolved by the discovery that prostaglandins at sites of tissue damage were synthesized by an inducible COX (COX-2) formed by a gene distinct from that producing the constitutive enzyme (COX-1), responsible for the formation of prostaglandins that serve an essential physiological function.	Prostaglandins	55-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-139
12973428-5	1999	The reason for this was resolved by the discovery that prostaglandins at sites of tissue damage were synthesized by an inducible COX (COX-2) formed by a gene distinct from that producing the constitutive enzyme (COX-1), responsible for the formation of prostaglandins that serve an essential physiological function.	Prostaglandins	253-267	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-139
12973428-7	1999	The focus on COX-2 has also expanded our knowledge of the pathophysiological significance of prostanoids and raised the possibility of new uses for selective COX-2 inhibitors, for example, in colon cancer, premature labor and possibly Alzheimer"s disease.	Prostaglandins	93-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
12973429-10	1999	This difference is therapeutically significant and selective inhibitors of COX-2 exhibit antiinflammatory potency without the gastric and renal toxicities of the aspirin-like drugs.	Aspirin	162-169	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
12973431-4	1999	There are two isoforms of COX, the constitutive enzyme COX-1, which is responsible for the production of PGs with general housekeeping functions such as maintenance of renal perfusion and a protective effect on the gastric mucosa against ulceration; and the inducible enzyme COX-2, which is responsible for the production of proinflammatory PGs.	Prostaglandins	105-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	275-280
10225537-3	1999	In contrast, COX-2 is the inducible form responsible for the production of prostanoids in response to a variety of evoking stimuli in different tissues and for mediation of inflammation and pain in certain diseases.	Prostaglandins	75-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
10225537-6	1999	Besides its induction in cells at inflammatory sites, COX-2 is known to be induced in the kidney in response to sodium depletion or in hyperfiltration states; in postsynaptic excitatory neurons in the brain after electroconvulsive stimulation, in the ovary and uterus during ovulation and implantation; in intestinal epithelium after bacterial infection; as well as in colon adenoma and carcinoma cells.	Sodium	112-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-59
10225538-0	1999	Update on clinical developments with celecoxib, a new specific COX-2 inhibitor: what can we expect?	Celecoxib	37-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-68
10225538-4	1999	Compelling evidence suggests that COX-1 synthesizes prostaglandins that are involved in the regulation of normal cell activity (including G1 cytoprotection), whereas COX-2 appears to produce prostaglandins mainly at sites of inflammation.	Prostaglandins	191-205	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	166-171
10225538-13	1999	These preliminary trials show that celecoxib achieves analgesic and antiinflammatory efficacy in arthritis through specific COX-2 inhibition without showing evidence of two of the toxic effects of COX-1 inhibition associated with NSAID.	Celecoxib	35-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	124-129
10049544-1	1999	The adsorption of Cd(II) and Co(II) onto goethite was measured at five temperatures between 10 and 70 degrees C. For both cations the amount adsorbed at any given pH increased as the temperature was increased.	goethite	41-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-35
10075740-2	1999	COX-2 is the highly inducible isozyme of COX which is responsible for much of the prostaglandin production in inflammation and is a key factor in colon carcinogenesis.	Prostaglandins	82-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
10075740-3	1999	Because COX-2 activity can be rate-limiting in prostaglandin formation, COX-2 expression must be regulated tightly.	Prostaglandins	47-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	8-13
10075740-3	1999	Because COX-2 activity can be rate-limiting in prostaglandin formation, COX-2 expression must be regulated tightly.	Prostaglandins	47-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
10070155-6	1999	The relative contribution of COX-1 and COX-2 to PGE2 synthesis was consistent with the immunohistochemical results: in the intact ductus, PGE2 formation was catalyzed by both COX-1 and COX-2 in equivalent proportions; in the endothelium-denuded ductus, COX-2 no longer played a significant role in PGE2 synthesis.	Dinoprostone	48-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	185-190
10066822-13	1999	Rather than acting directly via nuclear receptors, MP AA activates COX-2-dependent prostaglandin production by a PKC/p42/p44 MAPK/p38 kinase-sensitive pathway in which PI 3-kinase plays a significant role.	Prostaglandins	83-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-72
10070155-6	1999	The relative contribution of COX-1 and COX-2 to PGE2 synthesis was consistent with the immunohistochemical results: in the intact ductus, PGE2 formation was catalyzed by both COX-1 and COX-2 in equivalent proportions; in the endothelium-denuded ductus, COX-2 no longer played a significant role in PGE2 synthesis.	Dinoprostone	48-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	185-190
10070155-6	1999	The relative contribution of COX-1 and COX-2 to PGE2 synthesis was consistent with the immunohistochemical results: in the intact ductus, PGE2 formation was catalyzed by both COX-1 and COX-2 in equivalent proportions; in the endothelium-denuded ductus, COX-2 no longer played a significant role in PGE2 synthesis.	Dinoprostone	138-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-44
10070155-6	1999	The relative contribution of COX-1 and COX-2 to PGE2 synthesis was consistent with the immunohistochemical results: in the intact ductus, PGE2 formation was catalyzed by both COX-1 and COX-2 in equivalent proportions; in the endothelium-denuded ductus, COX-2 no longer played a significant role in PGE2 synthesis.	Dinoprostone	138-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	185-190
10193997-3	1999	Unlike conventional nonsteroidal anti-inflammatory drugs, which inhibit both forms of the COX enzyme, celecoxib inhibits COX-2 preferentially to COX-1 in vitro.	Celecoxib	102-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-126
10070155-6	1999	The relative contribution of COX-1 and COX-2 to PGE2 synthesis was consistent with the immunohistochemical results: in the intact ductus, PGE2 formation was catalyzed by both COX-1 and COX-2 in equivalent proportions; in the endothelium-denuded ductus, COX-2 no longer played a significant role in PGE2 synthesis.	Dinoprostone	138-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	185-190
10070155-6	1999	The relative contribution of COX-1 and COX-2 to PGE2 synthesis was consistent with the immunohistochemical results: in the intact ductus, PGE2 formation was catalyzed by both COX-1 and COX-2 in equivalent proportions; in the endothelium-denuded ductus, COX-2 no longer played a significant role in PGE2 synthesis.	Dinoprostone	138-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-44
10070155-6	1999	The relative contribution of COX-1 and COX-2 to PGE2 synthesis was consistent with the immunohistochemical results: in the intact ductus, PGE2 formation was catalyzed by both COX-1 and COX-2 in equivalent proportions; in the endothelium-denuded ductus, COX-2 no longer played a significant role in PGE2 synthesis.	Dinoprostone	138-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	185-190
10070155-6	1999	The relative contribution of COX-1 and COX-2 to PGE2 synthesis was consistent with the immunohistochemical results: in the intact ductus, PGE2 formation was catalyzed by both COX-1 and COX-2 in equivalent proportions; in the endothelium-denuded ductus, COX-2 no longer played a significant role in PGE2 synthesis.	Dinoprostone	138-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	185-190
10070155-7	1999	NS-398, a selective inhibitor of COX-2, was 66% as effective as the selective COX-1 inhibitor valeryl salicylate and the nonselective COX inhibitor indomethacin in causing contraction of the ductus in vitro.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	0-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-38
18967505-0	1999	Design of Schiff base complexes of Co(II) for the preparation of iodide-selective polymeric membrane electrodes.	Schiff Bases	10-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-41
10217524-15	1999	Dexamethasone (100 nM), the non-selective cyclo-oxygenase (COX) inhibitor indomethacin (3 microM) or the selective COX-2 inhibitor L-745,337 (0.3 microM) completely inhibited synthesis of PGE2.	l-745	131-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-120
10217524-21	1999	The induction of COX-2 protein by the cytokine mixture was attenuated by dexamethasone (100 nM), whereas the level of COX-1 protein was unaffected by either the cytokines or by dexamethasone.	Dexamethasone	73-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22
10217524-23	1999	Cytokine-induced, COX-2-dependent eicosanoid production inhibits DNA synthesis.	Eicosanoids	34-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-23
10096266-6	1999	RESULTS: Rofecoxib showed a >800-fold COX-2 selectivity with use of CHO cells that express human COX-1 and COX-2.	rofecoxib	9-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-115
18967505-0	1999	Design of Schiff base complexes of Co(II) for the preparation of iodide-selective polymeric membrane electrodes.	Iodides	65-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-41
10091674-1	1999	Comparative computer modeling of the X-ray crystal structures of cyclooxygenase isoforms COX-1 and COX-2 has led to the design of COX-2 selectivity into the nonselective inhibitor flurbiprofen.	Flurbiprofen	180-192	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-104
10091674-1	1999	Comparative computer modeling of the X-ray crystal structures of cyclooxygenase isoforms COX-1 and COX-2 has led to the design of COX-2 selectivity into the nonselective inhibitor flurbiprofen.	Flurbiprofen	180-192	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	130-135
10091674-0	1999	Structure-based design of COX-2 selectivity into flurbiprofen.	Flurbiprofen	49-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-31
10091674-2	1999	The COX-2 modeling was based on a postulated binding mode for flurbiprofen and took advantage of a small alcove in the COX-2 active site created by different positions of the Leu384 sidechain between COX-1 and COX-2.	Flurbiprofen	62-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
10091674-3	1999	The design hypothesis was tested by synthesis and biological assay of a series of flurbiprofen analogs, culminating in the discovery of several inhibitors having up to 78-fold selectivity for COX-2 over COX-1.	Flurbiprofen	82-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	192-197
10093892-4	1999	Meanwhile, the specific COX-2 inhibitors celecoxib and rofecoxib are being tested worldwide in phase III clinical trials on patients with rheumatoid arthritis and osteoarthritis.	Celecoxib	41-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
10093892-4	1999	Meanwhile, the specific COX-2 inhibitors celecoxib and rofecoxib are being tested worldwide in phase III clinical trials on patients with rheumatoid arthritis and osteoarthritis.	rofecoxib	55-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
18967489-2	1999	During the cathodic scan, the last one is reduced to a transient Co(0) species that catalyses the reduction of hydrogen ion to the hydrogen molecule by a mechanism alike to that emphasized for the Co(II)-sulfide ion system (F.G. Banica, N. Spataru, T. Spataru, Electroanalysis 9 (1997) 1341).	co(0)	65-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	197-202
10091607-5	1999	Increases in PGE2 correlated with the induction of COX-2 protein expression.	Dinoprostone	13-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-56
10091607-6	1999	The accumulation of PGE2 elicited by a combination of IL-1 beta/TNF-alpha correlated closely with the temporal pattern of COX-2 protein expression, which reflected the induction of COX-2 mRNA.	Dinoprostone	20-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-127
10091607-6	1999	The accumulation of PGE2 elicited by a combination of IL-1 beta/TNF-alpha correlated closely with the temporal pattern of COX-2 protein expression, which reflected the induction of COX-2 mRNA.	Dinoprostone	20-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	181-186
10091607-10	1999	Our results suggest that COX-2 expression is a major target for IL-13-mediated abrogation of prostaglandin release by HMC and support that this process takes place by transcriptional inhibition of the COX-2 gene.	Prostaglandins	93-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-30
10065757-3	1999	Indomethacin, a non-selective COX-1/COX-2 inhibitor, and NS-398, a selective COX-2 inhibitor, completely inhibited PGE2 production by IL-1beta-stimulated cells.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	57-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-82
10065757-3	1999	Indomethacin, a non-selective COX-1/COX-2 inhibitor, and NS-398, a selective COX-2 inhibitor, completely inhibited PGE2 production by IL-1beta-stimulated cells.	Dinoprostone	115-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-82
10065757-5	1999	Dexamethasone inhibited COX-2 mRNA expression, COX activity and PGE2 production in IL-1beta-stimulated cells.	Dexamethasone	0-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
10065757-9	1999	These data suggest that COX-2 is primarily responsible for PGE2 production by IL-1beta-stimulated human PDL fibroblasts and that IL-4 inhibited PGE2 production by IL-1beta-stimulated PDL fibroblasts through down-regulation of COX-2 expression, while IFN-gamma suppressed the PGE2 production with no effect on COX-2 expression.	Dinoprostone	59-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
9918670-2	1999	Cu(II), Zn(II), Cd(II), Co(II), and Ni(II) may be determined by changes they induce in the fluorescence lifetime and intensity of site-specifically labeled fluorescent variants of apocarbonic anhydrase II.	cu(ii)	0-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
10217458-1	1999	We have applied computer simulation technique to study interaction of two anti-inflammatory drugs (NSAIDs) indoprofen and NS398 with cyclooxygenase (COX-1 and COX-2) enzymes.	Indoprofen	107-117	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	159-164
10217458-1	1999	We have applied computer simulation technique to study interaction of two anti-inflammatory drugs (NSAIDs) indoprofen and NS398 with cyclooxygenase (COX-1 and COX-2) enzymes.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	122-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	159-164
10217458-9	1999	We have observed perturbative changes in COX-1 and COX-2 structures due to indoprofen and NS398.	Indoprofen	75-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-56
10217458-9	1999	We have observed perturbative changes in COX-1 and COX-2 structures due to indoprofen and NS398.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	90-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-56
10217458-10	1999	In case of indoprofen specific changes between COX-1 and COX-2 were noted in helix D, H6, S6 and helix H8 in the cyclooxygenase cavity.	Indoprofen	11-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-62
10087724-3	1999	Thus, COX-2 is expressed in HUVEC from preeclampsia but not in normal pregnancy and affects the release of prostacyclin suggesting the involvement of COX-2 in the pathogenesis of preeclampsia.	Epoprostenol	107-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	6-11
10087724-3	1999	Thus, COX-2 is expressed in HUVEC from preeclampsia but not in normal pregnancy and affects the release of prostacyclin suggesting the involvement of COX-2 in the pathogenesis of preeclampsia.	Epoprostenol	107-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	150-155
10328326-2	1999	Recent information indicates that prostanoids are produced by two cyclooxygenase (COX) enzymes, COX-1 and COX-2.	Prostaglandins	34-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-111
10328326-8	1999	While not detected in unstimulated normal mucosal cells and cancer cells, COX-2 protein was induced by both lipopolysaccharide (LPS) and LPC.	Lysophosphatidylcholines	137-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
10328326-10	1999	In freshly isolated normal gallbladder mucosal cells, continuously produced 6 keto PGF1alpha was inhibited by both COX-1 and COX-2 inhibitors while PGE2 levels were not affected.	keto pgf1alpha	78-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-130
10328326-11	1999	Both LPS and LPC stimulated PGE2 and 6 keto PGF1alpha formation were blocked by COX-2 inhibitors in freshly isolated, normal human gallbladder mucosal cells and in the gallbladder cancer cells.	Dinoprostone	28-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-85
10328326-12	1999	The prostanoid response of gallbladder cells stimulated by proinflammatory agents is inhibited by COX-2 inhibitors suggesting that these agents may be effective in treating the pain and inflammation of gallbladder disease.	Prostaglandins	4-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-103
18967489-2	1999	During the cathodic scan, the last one is reduced to a transient Co(0) species that catalyses the reduction of hydrogen ion to the hydrogen molecule by a mechanism alike to that emphasized for the Co(II)-sulfide ion system (F.G. Banica, N. Spataru, T. Spataru, Electroanalysis 9 (1997) 1341).	Hydrogen	111-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	197-202
18967489-2	1999	During the cathodic scan, the last one is reduced to a transient Co(0) species that catalyses the reduction of hydrogen ion to the hydrogen molecule by a mechanism alike to that emphasized for the Co(II)-sulfide ion system (F.G. Banica, N. Spataru, T. Spataru, Electroanalysis 9 (1997) 1341).	Hydrogen	131-139	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	197-202
18967489-2	1999	During the cathodic scan, the last one is reduced to a transient Co(0) species that catalyses the reduction of hydrogen ion to the hydrogen molecule by a mechanism alike to that emphasized for the Co(II)-sulfide ion system (F.G. Banica, N. Spataru, T. Spataru, Electroanalysis 9 (1997) 1341).	Sulfides	204-211	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	197-202
9915849-3	1999	Experiments on cells transfected with either COX alone revealed subtle differences between the PG-biosynthetic properties of the two isozymes in that COX-1 and COX-2 were favored over the other in the presence of high and low exogenous AA concentrations, respectively.	Prostaglandins	95-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	160-165
9920782-7	1999	In addition, several NSAIDs which are also PPARgamma activators, such as indomethacin, inhibited COX-2 expression in glial cells.	Indomethacin	73-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
9915849-5	1999	When PLA2 and COX were coexpressed, AA released by cPLA2, sPLA2-IIA and sPLA2-V was converted to PGE2 by both COX-1 and COX-2 during the immediate response and predominantly by COX-2 during the delayed response.	Dinoprostone	97-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-125
10021918-0	1999	Substituted heterocyclic analogs as selective COX-2 inhibitors in the flosulide class.	flosulide	70-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
9915849-5	1999	When PLA2 and COX were coexpressed, AA released by cPLA2, sPLA2-IIA and sPLA2-V was converted to PGE2 by both COX-1 and COX-2 during the immediate response and predominantly by COX-2 during the delayed response.	Dinoprostone	97-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	177-182
10919714-4	1999	We examined the relationship between COX-2 expression and VEGF induction in response to cobalt chloride (CoCl2)-simulated hypoxia in three human prostate cancer cell lines with differing biological phenotypes.	cobaltous chloride	88-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-42
9874808-0	1999	Systemic biosynthesis of prostacyclin by cyclooxygenase (COX)-2: the human pharmacology of a selective inhibitor of COX-2.	Epoprostenol	25-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-63
9874808-0	1999	Systemic biosynthesis of prostacyclin by cyclooxygenase (COX)-2: the human pharmacology of a selective inhibitor of COX-2.	Epoprostenol	25-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-121
9874808-9	1999	By contrast, both ibuprofen and celecoxib suppressed a biochemical index of COX-2 activity (endotoxin induced PGE2 in whole blood ex vivo) to a comparable degree (-93.3 +/- 2% vs. -83 +/- 6.1%).	Ibuprofen	18-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-81
9874808-9	1999	By contrast, both ibuprofen and celecoxib suppressed a biochemical index of COX-2 activity (endotoxin induced PGE2 in whole blood ex vivo) to a comparable degree (-93.3 +/- 2% vs. -83 +/- 6.1%).	Celecoxib	32-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-81
9874808-9	1999	By contrast, both ibuprofen and celecoxib suppressed a biochemical index of COX-2 activity (endotoxin induced PGE2 in whole blood ex vivo) to a comparable degree (-93.3 +/- 2% vs. -83 +/- 6.1%).	Dinoprostone	110-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-81
10668483-4	1999	In this study, we determined whether (1) COX-2 was overexpressed in squamous cell carcinoma of the head and neck (HNSCC) and whether (2) retinoids, a class of chemopreventive agents, blocked epidermal growth factor (EGF)-mediated activation of COX-2 expression.	Retinoids	137-146	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	244-249
10668483-8	1999	Because retinoids protect against oral cavity cancer, we investigated whether retinoids could suppress EGF-mediated induction of COX-2 in cultured oral squamous carcinoma cells.	Retinoids	78-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-134
10668483-12	1999	Moreover, the anticancer properties of retinoids may be due, in part, to inhibition of COX-2 expression.	Retinoids	39-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-92
10668483-13	1999	Combining a retinoid with a selective COX-2 inhibitor may be more effective than either agent alone in preventing cancer of the upper aerodigestive tract.	Retinoids	12-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-43
10919714-4	1999	We examined the relationship between COX-2 expression and VEGF induction in response to cobalt chloride (CoCl2)-simulated hypoxia in three human prostate cancer cell lines with differing biological phenotypes.	cobaltous chloride	105-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-42
10223523-6	1999	A brief review of the molecular biology, pharmacology, and primary actions of COX-2 outside of the nervous system provides a context for understanding potential neurobiological roles for COX-2 and prostanoid production.	Prostaglandins	197-207	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-83
10223523-2	1999	Two isoforms of cyclooxygenase (COX), the enzyme that catalyzes the conversion of arachidonic acid to prostanoids, are now recognized: a constitutively expressed COX-1 and a highly regulated COX-2.	Arachidonic Acid	82-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	191-196
10919714-11	1999	Moreover, the increases in VEGF mRNA and protein secretion induced by CoCl2 in PC-3ML cells were significantly suppressed following exposure to NS398, a selective COX-2 inhibitor.	cobaltous chloride	70-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	163-168
10223523-2	1999	Two isoforms of cyclooxygenase (COX), the enzyme that catalyzes the conversion of arachidonic acid to prostanoids, are now recognized: a constitutively expressed COX-1 and a highly regulated COX-2.	Prostaglandins	102-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	191-196
10919714-11	1999	Moreover, the increases in VEGF mRNA and protein secretion induced by CoCl2 in PC-3ML cells were significantly suppressed following exposure to NS398, a selective COX-2 inhibitor.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	144-149	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	163-168
10919714-12	1999	Finally, the effect of COX-2 inhibition on CoCl2-induced VEGF production was reversed by the treatment with exogenous PGE2.	cobaltous chloride	43-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-28
10919714-12	1999	Finally, the effect of COX-2 inhibition on CoCl2-induced VEGF production was reversed by the treatment with exogenous PGE2.	Dinoprostone	118-122	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-28
10919714-13	1999	Our data demonstrate that VEGF induction by cobalt chloride-simulated hypoxia is maintained by a concomitant, persistent induction of COX-2 expression and sustained elevation of PGE2 synthesis in a human metastatic prostate cancer cell line, and suggest that COX-2 activity, reflected by PGE2 production, is involved in hypoxia-induced VEGF expression, and thus, modulates prostatic tumor angiogenesis.	cobaltous chloride	44-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-139
10919714-13	1999	Our data demonstrate that VEGF induction by cobalt chloride-simulated hypoxia is maintained by a concomitant, persistent induction of COX-2 expression and sustained elevation of PGE2 synthesis in a human metastatic prostate cancer cell line, and suggest that COX-2 activity, reflected by PGE2 production, is involved in hypoxia-induced VEGF expression, and thus, modulates prostatic tumor angiogenesis.	cobaltous chloride	44-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	259-264
10815617-14	1999	The results suggested that (i) PGE2 can initiate negative feedback regulation in the induction of COX-2 elicited by IL-1beta in endothelial cells, (ii) the inhibition of PGE2 on COX-2 protein and activity in IL-1beta treated HUVEC is mediated by cAMP and (iii) the therapeutic use of PGE2 in the condition which COX-2 has been involved may have different roles.	Dinoprostone	31-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-103
17638098-0	1999	Etodolac: an overview of a selective COX-2 inhibitor.	Etodolac	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-42
17638098-1	1999	Etodolac is a non-steroidal anti-inflammatory drug (NSAID) which has been shown to be effective in the treatment of rheumatoid arthritis and osteoarthritis and a selective COX-2 inhibitor in a wide range of clinically relevant assays in direct comparisons with other NSAIDs.	Etodolac	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	172-177
17638098-5	1999	In summary, etodolac is a well established selective COX-2 inhibitor that has been shown not to suppress gastric or duodenal prostaglandins, to have minimal hepatic or renal effects and to have favourable GI tolerability in comparison with ibuprofen.	Etodolac	12-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-58
10815617-2	1999	Cyclooxygenase (COX), which exists as COX-1 and COX-2 isoforms, is the first enzyme in the pathway in which arachidonic acid is converted to PGs.	Arachidonic Acid	108-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-53
10815617-2	1999	Cyclooxygenase (COX), which exists as COX-1 and COX-2 isoforms, is the first enzyme in the pathway in which arachidonic acid is converted to PGs.	Prostaglandins	141-144	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-53
10815617-5	1999	Here, we have investigated the effects of PGE2 on the induction of COX-2 in human umbilical vein endothelial cells (HUVEC) treated with interleukin-1beta (IL-1beta 1 ng/ml).	Dinoprostone	42-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-72
10815617-10	1999	Interestingly, PGE2 (3 microM for 24h) can inhibit COX-2 protein, but not COX-1 protein, expressed in HUVEC treated with IL-1beta.	Dinoprostone	15-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-56
9864384-1	1999	Two isoforms of cyclo-oxygenase (COX) have been identified; a constitutive isoform (COX-1), found in abundance in platelets and the vascular endothelium, considered important for the roles of prostanoids and a cytokine/mitogen inducible isoform (COX-2), which is thought responsible for the majority of the inflammatory prostanoid production.	Prostaglandins	192-203	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	246-251
9864384-1	1999	Two isoforms of cyclo-oxygenase (COX) have been identified; a constitutive isoform (COX-1), found in abundance in platelets and the vascular endothelium, considered important for the roles of prostanoids and a cytokine/mitogen inducible isoform (COX-2), which is thought responsible for the majority of the inflammatory prostanoid production.	Prostaglandins	192-202	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	246-251
10815617-14	1999	The results suggested that (i) PGE2 can initiate negative feedback regulation in the induction of COX-2 elicited by IL-1beta in endothelial cells, (ii) the inhibition of PGE2 on COX-2 protein and activity in IL-1beta treated HUVEC is mediated by cAMP and (iii) the therapeutic use of PGE2 in the condition which COX-2 has been involved may have different roles.	Dinoprostone	31-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	178-183
10815617-14	1999	The results suggested that (i) PGE2 can initiate negative feedback regulation in the induction of COX-2 elicited by IL-1beta in endothelial cells, (ii) the inhibition of PGE2 on COX-2 protein and activity in IL-1beta treated HUVEC is mediated by cAMP and (iii) the therapeutic use of PGE2 in the condition which COX-2 has been involved may have different roles.	Dinoprostone	31-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	178-183
10815617-14	1999	The results suggested that (i) PGE2 can initiate negative feedback regulation in the induction of COX-2 elicited by IL-1beta in endothelial cells, (ii) the inhibition of PGE2 on COX-2 protein and activity in IL-1beta treated HUVEC is mediated by cAMP and (iii) the therapeutic use of PGE2 in the condition which COX-2 has been involved may have different roles.	Dinoprostone	170-174	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-103
10815617-14	1999	The results suggested that (i) PGE2 can initiate negative feedback regulation in the induction of COX-2 elicited by IL-1beta in endothelial cells, (ii) the inhibition of PGE2 on COX-2 protein and activity in IL-1beta treated HUVEC is mediated by cAMP and (iii) the therapeutic use of PGE2 in the condition which COX-2 has been involved may have different roles.	Dinoprostone	170-174	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	178-183
10815617-14	1999	The results suggested that (i) PGE2 can initiate negative feedback regulation in the induction of COX-2 elicited by IL-1beta in endothelial cells, (ii) the inhibition of PGE2 on COX-2 protein and activity in IL-1beta treated HUVEC is mediated by cAMP and (iii) the therapeutic use of PGE2 in the condition which COX-2 has been involved may have different roles.	Dinoprostone	170-174	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	178-183
10815617-14	1999	The results suggested that (i) PGE2 can initiate negative feedback regulation in the induction of COX-2 elicited by IL-1beta in endothelial cells, (ii) the inhibition of PGE2 on COX-2 protein and activity in IL-1beta treated HUVEC is mediated by cAMP and (iii) the therapeutic use of PGE2 in the condition which COX-2 has been involved may have different roles.	Cyclic AMP	246-250	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-103
10815617-14	1999	The results suggested that (i) PGE2 can initiate negative feedback regulation in the induction of COX-2 elicited by IL-1beta in endothelial cells, (ii) the inhibition of PGE2 on COX-2 protein and activity in IL-1beta treated HUVEC is mediated by cAMP and (iii) the therapeutic use of PGE2 in the condition which COX-2 has been involved may have different roles.	Cyclic AMP	246-250	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	178-183
10815617-14	1999	The results suggested that (i) PGE2 can initiate negative feedback regulation in the induction of COX-2 elicited by IL-1beta in endothelial cells, (ii) the inhibition of PGE2 on COX-2 protein and activity in IL-1beta treated HUVEC is mediated by cAMP and (iii) the therapeutic use of PGE2 in the condition which COX-2 has been involved may have different roles.	Cyclic AMP	246-250	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	178-183
10815617-14	1999	The results suggested that (i) PGE2 can initiate negative feedback regulation in the induction of COX-2 elicited by IL-1beta in endothelial cells, (ii) the inhibition of PGE2 on COX-2 protein and activity in IL-1beta treated HUVEC is mediated by cAMP and (iii) the therapeutic use of PGE2 in the condition which COX-2 has been involved may have different roles.	Dinoprostone	170-174	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-103
10815617-14	1999	The results suggested that (i) PGE2 can initiate negative feedback regulation in the induction of COX-2 elicited by IL-1beta in endothelial cells, (ii) the inhibition of PGE2 on COX-2 protein and activity in IL-1beta treated HUVEC is mediated by cAMP and (iii) the therapeutic use of PGE2 in the condition which COX-2 has been involved may have different roles.	Dinoprostone	170-174	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	178-183
10815617-14	1999	The results suggested that (i) PGE2 can initiate negative feedback regulation in the induction of COX-2 elicited by IL-1beta in endothelial cells, (ii) the inhibition of PGE2 on COX-2 protein and activity in IL-1beta treated HUVEC is mediated by cAMP and (iii) the therapeutic use of PGE2 in the condition which COX-2 has been involved may have different roles.	Dinoprostone	170-174	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	178-183
10637962-5	1999	CSI firstly inhibit COX-1/COX-2 to a different extent and in a different manner.	csi	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-31
10101953-0	1999	Selective COX-2 inhibitors: is the water becoming muddy?	Water	35-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
9822711-2	1998	Up-regulation of COX-2 is responsible for increased PG production in inflammation and is antagonized by corticosteriods such as dexamethasone.	Prostaglandins	52-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22
9893042-9	1998	Selective inhibition of COX-2 expression with the NF-kappaB super-repressor may be useful in distinguishing the role of inducible versus constitutive prostaglandins in intestinal function and provides greater specificity than pharmacological inhibitors.	Prostaglandins	150-164	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
18967436-4	1998	The method proposed was applied in the analysis of a new type electroless copper plating solutions containing Co(II)-ethylenediamine complex compounds as reducing agents.	Copper	74-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-116
10422544-0	1999	Update on clinical developments with celecoxib, a new specific COX-2 inhibitor: what can we expect?	Celecoxib	37-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-68
10422544-4	1999	Compelling evidence suggests that COX-1 synthesizes prostaglandins that are involved in the regulation of normal cell activity (including GI cytoprotection), whereas COX-2 appears to produce prostaglandins mainly at sites of inflammation.	Prostaglandins	191-205	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	166-171
10422544-13	1999	These preliminary trials show that celecoxib achieves analgesic and anti-inflammatory efficacy in arthritis through specific COX-2 inhibition without showing evidence of two of the toxic effects of COX-1 inhibition associated with NSAIDs.	Celecoxib	35-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-130
9990216-5	1998	The increased production of prostaglandin E2 by upregulation of COX-2 increases IL-6 production.	Dinoprostone	28-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-69
9990216-6	1998	By utilizing a COX-2 blocker, it is possible to decrease IL-6 production via reduction of prostanoid production, thereby attenuating the systemic inflammatory response.	Prostaglandins	90-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-20
9875720-0	1998	COX-2 inhibitor prevents the development of hyperalgesia induced by intrathecal NMDA or AMPA.	N-Methylaspartate	80-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
9875720-0	1998	COX-2 inhibitor prevents the development of hyperalgesia induced by intrathecal NMDA or AMPA.	alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid	88-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
9875720-4	1998	These data suggest that COX-2 plays an important role in spinal thermal nociceptive transmission when neurons in the spinal cord are facilitated by NMDA or AMPA.	N-Methylaspartate	148-152	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
18967436-1	1998	A potentiometric titration for cobalt(II) determination in the presence of Co(III) based on the oxidation of Co(II) with Na(2)CrO(4) in ethylenediamine medium and back-titration of the oxidant excess with (NH(4))(2)Fe(SO(4))(2) in acid medium is described.	Cobalt(2+)	31-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-115
18967436-1	1998	A potentiometric titration for cobalt(II) determination in the presence of Co(III) based on the oxidation of Co(II) with Na(2)CrO(4) in ethylenediamine medium and back-titration of the oxidant excess with (NH(4))(2)Fe(SO(4))(2) in acid medium is described.	na(2)cro(4)	121-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-115
18967436-1	1998	A potentiometric titration for cobalt(II) determination in the presence of Co(III) based on the oxidation of Co(II) with Na(2)CrO(4) in ethylenediamine medium and back-titration of the oxidant excess with (NH(4))(2)Fe(SO(4))(2) in acid medium is described.	ethylenediamine	136-151	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-115
9822711-2	1998	Up-regulation of COX-2 is responsible for increased PG production in inflammation and is antagonized by corticosteriods such as dexamethasone.	Dexamethasone	128-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22
9822711-3	1998	In human pulmonary A549 cells, interleukin-1beta (IL-1beta) increases prostaglandin E2 (PGE2) synthesis via dexamethasone-sensitive induction of COX-2.	Dinoprostone	70-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-150
9822711-3	1998	In human pulmonary A549 cells, interleukin-1beta (IL-1beta) increases prostaglandin E2 (PGE2) synthesis via dexamethasone-sensitive induction of COX-2.	Dinoprostone	88-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-150
9822711-3	1998	In human pulmonary A549 cells, interleukin-1beta (IL-1beta) increases prostaglandin E2 (PGE2) synthesis via dexamethasone-sensitive induction of COX-2.	Dexamethasone	108-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-150
9822711-4	1998	Nuclear run-off assays showed that COX-2 transcription rate was repressed 25-40% by dexamethasone, while PGE2 release, COX activity, and COX-2 protein were totally repressed.	Dexamethasone	84-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40
9822711-6	1998	Preinduced COX-2 mRNA was also potently repressed by dexamethasone, yet suppression of transcription by actinomycin D showed little effect.	Dexamethasone	53-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-16
9822711-7	1998	This dexamethasone-dependent repression involved a reduced COX-2 mRNA half-life, was blocked by actinomycin D or cycloheximide, and was antagonized by the steroid antagonist RU38486.	Dexamethasone	5-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-64
9822711-7	1998	This dexamethasone-dependent repression involved a reduced COX-2 mRNA half-life, was blocked by actinomycin D or cycloheximide, and was antagonized by the steroid antagonist RU38486.	Dactinomycin	96-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-64
9822711-7	1998	This dexamethasone-dependent repression involved a reduced COX-2 mRNA half-life, was blocked by actinomycin D or cycloheximide, and was antagonized by the steroid antagonist RU38486.	Cycloheximide	113-126	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-64
9822711-7	1998	This dexamethasone-dependent repression involved a reduced COX-2 mRNA half-life, was blocked by actinomycin D or cycloheximide, and was antagonized by the steroid antagonist RU38486.	Steroids	155-162	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-64
9822711-7	1998	This dexamethasone-dependent repression involved a reduced COX-2 mRNA half-life, was blocked by actinomycin D or cycloheximide, and was antagonized by the steroid antagonist RU38486.	Mifepristone	174-181	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-64
9822711-8	1998	Repression of IL-1beta-induced PGE2 release, COX activity, and COX-2 protein by actinomycin D was only effective within the first hour following IL-1beta treatment, while dexamethasone was effective when added up to 10 h later, suggesting a functional role for post-transcriptional mechanisms of repression.	Dactinomycin	80-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-68
9822711-9	1998	Following dexamethasone treatment, shortening of the average length of COX-2 mRNA poly(A) tails was observed.	Dexamethasone	10-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-76
9822711-11	1998	In conclusion, these data indicate a major role for post-transcriptional mechanisms in the dexamethasone-dependent repression of COX-2 that require de novo glucocorticoid receptor-dependent transcription and translation.	Dexamethasone	91-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-134
9824673-5	1998	We show here that PBN decreases steady state COX2 mRNA level and COX2 catalytic activity in macrophage cell culture at supra-pharmacological concentrations.	phenyl-N-tert-butylnitrone	18-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-49
9824673-5	1998	We show here that PBN decreases steady state COX2 mRNA level and COX2 catalytic activity in macrophage cell culture at supra-pharmacological concentrations.	phenyl-N-tert-butylnitrone	18-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-69
9824673-10	1998	Furthermore, we show that PBN inhibits COX2 catalytic activity, suggesting that PBN has an NSAID-like function.	phenyl-N-tert-butylnitrone	26-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-43
9824673-10	1998	Furthermore, we show that PBN inhibits COX2 catalytic activity, suggesting that PBN has an NSAID-like function.	phenyl-N-tert-butylnitrone	80-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-43
9866686-2	1998	Accordingly, we have exploited the heme-catalyzed hydroperoxidase activity of recombinant hCOX-2 to generate luminescence in the presence of luminol, or a cyclic naphthalene hydrazide, and the substrate arachidonic acid.	Heme	35-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-96
9866686-2	1998	Accordingly, we have exploited the heme-catalyzed hydroperoxidase activity of recombinant hCOX-2 to generate luminescence in the presence of luminol, or a cyclic naphthalene hydrazide, and the substrate arachidonic acid.	Luminol	141-148	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-96
9866686-2	1998	Accordingly, we have exploited the heme-catalyzed hydroperoxidase activity of recombinant hCOX-2 to generate luminescence in the presence of luminol, or a cyclic naphthalene hydrazide, and the substrate arachidonic acid.	cyclic naphthalene hydrazide	155-183	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-96
9866686-2	1998	Accordingly, we have exploited the heme-catalyzed hydroperoxidase activity of recombinant hCOX-2 to generate luminescence in the presence of luminol, or a cyclic naphthalene hydrazide, and the substrate arachidonic acid.	Arachidonic Acid	203-219	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-96
9866686-4	1998	Luminol luminescence was proportional to hCOX-2 concentration and gave accurate Km determinations for arachidonate.	Luminol	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-47
9849881-2	1998	SB 203580, an inhibitor of p38 MAPK, in the range 0.1-1 microM inhibited IL-1-stimulated PGE2 (but not arachidonic acid) release and this was associated with inhibition of induction of COX-2 protein and mRNA.	SB 203580	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	185-190
9808683-1	1998	Prostaglandins are generated through two isoforms of the enzyme cyclooxygenase, the constitutively expressed cyclooxygenase (Cox)-1 and Cox-2, which is induced at sites of inflammation.	Prostaglandins	0-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	136-141
9863649-1	1998	The non-steroidal anti-inflammatory drug (NSAID) indomethacin inhibits both constitutive and inducible forms of cyclo-oxygenase (COX-1 and COX-2, respectively), while nimesulide is a selective COX-2 inhibitor.	Indomethacin	49-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-144
9863649-1	1998	The non-steroidal anti-inflammatory drug (NSAID) indomethacin inhibits both constitutive and inducible forms of cyclo-oxygenase (COX-1 and COX-2, respectively), while nimesulide is a selective COX-2 inhibitor.	Indomethacin	49-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	193-198
28976651-3	1998	We have compared nimesulide and acemetacin, two NSAID that cause relatively little gastric damage, with indomethacin for effects on purified COX-1 and COX-2.	acemetacin	32-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-156
28976651-3	1998	We have compared nimesulide and acemetacin, two NSAID that cause relatively little gastric damage, with indomethacin for effects on purified COX-1 and COX-2.	Indomethacin	104-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-156
28976651-6	1998	Inhibition of purified COX-2 occurred with nimesulide and indomethacin (IC50 values 90 and 4.1 mmol/L, respectively) but not acemetacin.	nimesulide	43-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-28
28976651-6	1998	Inhibition of purified COX-2 occurred with nimesulide and indomethacin (IC50 values 90 and 4.1 mmol/L, respectively) but not acemetacin.	Indomethacin	58-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-28
28976651-7	1998	All results with nimesulide are consistent with a preferential block of COX-2 that contributes to relatively little gastric damage in patients.	nimesulide	17-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
28976651-10	1998	Our previous leucocyte (COX-2) experiments required 24 h incubation, and hydrolysis of acemetacin to indomethacin presumably accounted for the COX-2 inhibition.	acemetacin	87-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
28976651-10	1998	Our previous leucocyte (COX-2) experiments required 24 h incubation, and hydrolysis of acemetacin to indomethacin presumably accounted for the COX-2 inhibition.	acemetacin	87-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	143-148
28976651-10	1998	Our previous leucocyte (COX-2) experiments required 24 h incubation, and hydrolysis of acemetacin to indomethacin presumably accounted for the COX-2 inhibition.	Indomethacin	101-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	143-148
9808683-4	1998	We examined the activity of nimesulide, a Cox-2 selective nonsteroidal antiinflammatory drug, in vitro against purified enzymes and in vivo in man.	nimesulide	28-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47
9808683-8	1998	Nimesulide was highly selective against ovine Cox-2, so that at concentrations attained in vivo, it had no effect on Cox-1 but completely suppressed Cox-2.	nimesulide	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	149-154
9808683-15	1998	Moreover, Cox-2 is expressed in man and generates prostaglandin I2.	Epoprostenol	50-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
9765255-7	1998	Both early and delayed production of PGE2 counteract the mitogenic effect of PDGF-BB and thrombin because: (i) pretreatment with the COX inhibitor ibuprofen markedly enhances the mitogenic effect of both peptides; (ii) blocking early synthesis of PGE2 greatly enhances extracellular signal-regulated kinase (ERK) activation by both growth factors; (iii) enhancement of DNA synthesis by ibuprofen is only lost when the inhibitor is added after COX-2 induction has occurred.	Dinoprostone	37-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	443-448
9795252-12	1998	Our results indicate that HA fragment, rather than physiologic native HA polymer, induces amnion cell-derived prostanoid production via increased COX-2 expression.	Prostaglandins	110-120	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	146-151
9795252-13	1998	COX-2-mediated prostanoid production is likely a key physiologic event in HA fragment-mediated cervical ripening and the labor onset.	Prostaglandins	15-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
9765255-7	1998	Both early and delayed production of PGE2 counteract the mitogenic effect of PDGF-BB and thrombin because: (i) pretreatment with the COX inhibitor ibuprofen markedly enhances the mitogenic effect of both peptides; (ii) blocking early synthesis of PGE2 greatly enhances extracellular signal-regulated kinase (ERK) activation by both growth factors; (iii) enhancement of DNA synthesis by ibuprofen is only lost when the inhibitor is added after COX-2 induction has occurred.	Ibuprofen	147-156	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	443-448
9893946-8	1998	These results suggest that the expression of mitochondrial encoded subunits (CO-I, CO-II and F0F1-ATPase 6) is up-regulated in response to oxygen and NO reactive species.	Oxygen	139-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
9873621-1	1998	A series of novel 2-pyridinyl-3-(4-methylsulfonyl)phenylpyridines has been synthesized and evaluated with respect to their ability to inhibit the isozymes of cyclooxygenase, COX-1, and COX-2.	2-pyridinyl-3-(4-methylsulfonyl)phenylpyridines	18-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	185-190
9873621-2	1998	Optimum COX-2 activity is observed by introduction of a substituent at C5 of the central pyridine.	pyridine	89-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	8-13
9869271-1	1998	Inhibitory activity and the mechanism of action of JTE-522 (4-(4-cyclohexyl-2-methyloxazol-5-yl)-2-fluorobenzenesulfonamid e), a novel selective cyclooxygenase (COX)-2 inhibitor, on human COX-1 and COX-2 were investigated and compared with those of reference compounds.	4-(4-cyclohexyl-2-methyloxazol-5-yl)-2-fluorobenzenesulfonamide	51-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	161-167
9869271-1	1998	Inhibitory activity and the mechanism of action of JTE-522 (4-(4-cyclohexyl-2-methyloxazol-5-yl)-2-fluorobenzenesulfonamid e), a novel selective cyclooxygenase (COX)-2 inhibitor, on human COX-1 and COX-2 were investigated and compared with those of reference compounds.	4-(4-cyclohexyl-2-methyloxazol-5-yl)-2-fluorobenzenesulfonamide	51-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	198-203
9869271-2	1998	In an enzyme assay, JTE-522 inhibited yeast-expressed human recombinant COX-2 with an IC50 value of 0.085 microM.	4-(4-cyclohexyl-2-methyloxazol-5-yl)-2-fluorobenzenesulfonamide	20-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
9869271-4	1998	In a cell-based assay, JTE-522 diminished lipopolysaccharide-induced prostaglandin E2 production in human peripheral blood mononuclear cells (COX-2) (IC50 value = 15.1 nM).	(2~{R})-2-[4-(3,5-dimethylphenyl)-3-fluoranyl-phenyl]propanoic acid	23-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	142-147
9869271-4	1998	In a cell-based assay, JTE-522 diminished lipopolysaccharide-induced prostaglandin E2 production in human peripheral blood mononuclear cells (COX-2) (IC50 value = 15.1 nM).	Dinoprostone	69-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	142-147
9869271-6	1998	JTE-522 showed highly selective inhibition of human COX-2, and its activity was more selective than that of other COX-2 inhibitors (NS-398 and SC-58635).	4-(4-cyclohexyl-2-methyloxazol-5-yl)-2-fluorobenzenesulfonamide	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-57
9869271-10	1998	These results indicate that JTE-522 is a highly selective, time-dependent and irreversible inhibitor of human COX-2.	4-(4-cyclohexyl-2-methyloxazol-5-yl)-2-fluorobenzenesulfonamide	28-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-115
9763540-5	1998	In addition, the induced release of PGE2 was inhibited by the COX-2-selective inhibitor, L-745,337.	Dinoprostone	36-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
9763540-5	1998	In addition, the induced release of PGE2 was inhibited by the COX-2-selective inhibitor, L-745,337.	l-745	89-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
9763540-10	1998	The ability of COX-2 activity to limit COX-2 expression in some cells but not others may contribute to the highly developed mechanisms involved in prostanoid release.	Prostaglandins	147-157	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-20
9763540-10	1998	The ability of COX-2 activity to limit COX-2 expression in some cells but not others may contribute to the highly developed mechanisms involved in prostanoid release.	Prostaglandins	147-157	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-44
9831331-4	1998	Zaltoprofen, loxoprofen-SRS (active metabolite of loxoprofen), 6-MNA (active metabolite of nabumetone) and ibuprofen showed intermediate COX-2 selectivity.	Ibuprofen	107-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-142
9766645-1	1998	Cyclooxygenase (COX)-2, an inducible enzyme that catalyzes the formation of prostaglandins and other eicosanoids from arachidonic acid, is constitutively expressed in LNCaP human prostate cancer cell line.	Prostaglandins	76-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-22
9766645-1	1998	Cyclooxygenase (COX)-2, an inducible enzyme that catalyzes the formation of prostaglandins and other eicosanoids from arachidonic acid, is constitutively expressed in LNCaP human prostate cancer cell line.	Eicosanoids	101-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-22
9766645-1	1998	Cyclooxygenase (COX)-2, an inducible enzyme that catalyzes the formation of prostaglandins and other eicosanoids from arachidonic acid, is constitutively expressed in LNCaP human prostate cancer cell line.	Arachidonic Acid	118-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-22
9812177-1	1998	Nimesulide is a selective COX-2 inhibitor used in a variety of inflammatory, pain and fever states.	nimesulide	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-31
9831331-5	1998	The lowest COX-2 selectivities, which means the highest COX-1 selectivities, were observed in indomethacin, aspirin, and oxaprozin.	Indomethacin	94-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-16
9831331-5	1998	The lowest COX-2 selectivities, which means the highest COX-1 selectivities, were observed in indomethacin, aspirin, and oxaprozin.	Aspirin	108-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-16
9831331-5	1998	The lowest COX-2 selectivities, which means the highest COX-1 selectivities, were observed in indomethacin, aspirin, and oxaprozin.	Oxaprozin	121-130	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-16
9831328-9	1998	In addition, the well-known protective action of aspirin on colon cancer may be through an action on COX-2, which is expressed in this disease.	Aspirin	49-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-106
9831329-1	1998	Cyclooxygenase (COX)-2 is the predominant COX isoform present at sites of inflammation, and produces prostaglandins (PG) that cause swelling and pain.	Prostaglandins	101-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-22
9831329-1	1998	Cyclooxygenase (COX)-2 is the predominant COX isoform present at sites of inflammation, and produces prostaglandins (PG) that cause swelling and pain.	Prostaglandins	117-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-22
19078321-1	1998	Numerous in vitro assay systems have been developed for testing and comparing the relative inhibitory activities of nonsteroidal anti-inflammatory drugs (NSAIDs) against cyclooxygenase (COX)- 1 and COX-2, the two COX isoforms responsible for prostaglandin biosynthesis.	Prostaglandins	242-255	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	198-203
9831329-2	1998	However, in situations where the release of protective PGs by COX-1 has been lost, the induction of COX-2 may compensate and reduce inflammatory responses.	Phosphatidylglycerols	55-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-105
9831330-3	1998	Standard non-steroidal anti-inflammatory drugs can be considered nonselective; compounds such as meloxicam and nimesulide can be classified as COX-2 preferential; and compounds such as SC 58125 and L-754,337 are selective for COX-2.	Meloxicam	97-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	143-148
9831330-3	1998	Standard non-steroidal anti-inflammatory drugs can be considered nonselective; compounds such as meloxicam and nimesulide can be classified as COX-2 preferential; and compounds such as SC 58125 and L-754,337 are selective for COX-2.	nimesulide	111-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	143-148
9831330-7	1998	Human pharmacology studies concentrating on the inhibition of prostanoid synthesis in target tissues are of paramount importance in determining the clinical relevance of COX-2 selectivity.	Prostaglandins	62-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	170-175
9831331-2	1998	We measured COX selectivity by using an intact cell assay system, and found that NS-398 is a highly COX-2-selective inhibitor.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	81-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-105
9831331-3	1998	Meloxicam, etodolac and diclofenac also showed high COX-2 selectivity.	Meloxicam	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-57
9831331-3	1998	Meloxicam, etodolac and diclofenac also showed high COX-2 selectivity.	Etodolac	11-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-57
9831331-3	1998	Meloxicam, etodolac and diclofenac also showed high COX-2 selectivity.	Diclofenac	24-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-57
9831331-4	1998	Zaltoprofen, loxoprofen-SRS (active metabolite of loxoprofen), 6-MNA (active metabolite of nabumetone) and ibuprofen showed intermediate COX-2 selectivity.	pyranoprofen	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-142
9831331-4	1998	Zaltoprofen, loxoprofen-SRS (active metabolite of loxoprofen), 6-MNA (active metabolite of nabumetone) and ibuprofen showed intermediate COX-2 selectivity.	loxoprofen active metabolite	13-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-142
9831331-4	1998	Zaltoprofen, loxoprofen-SRS (active metabolite of loxoprofen), 6-MNA (active metabolite of nabumetone) and ibuprofen showed intermediate COX-2 selectivity.	loxoprofen	13-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-142
9831331-4	1998	Zaltoprofen, loxoprofen-SRS (active metabolite of loxoprofen), 6-MNA (active metabolite of nabumetone) and ibuprofen showed intermediate COX-2 selectivity.	6-methoxy-2-naphthylacetic acid	63-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-142
9831331-4	1998	Zaltoprofen, loxoprofen-SRS (active metabolite of loxoprofen), 6-MNA (active metabolite of nabumetone) and ibuprofen showed intermediate COX-2 selectivity.	Nabumetone	91-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-142
19078322-4	1998	Meloxicam was investigated in several in vitro test systems in which it consistently demonstrated preferential COX-2 inhibition.	Meloxicam	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	111-116
9764845-5	1998	Calphostin C, a potent protein kinase C inhibitor, significantly reduced cholecalciferol-induced PGE2 production by inhibiting cholecalciferol-enhanced COX-2 mRNA and protein expression.	calphostin C	0-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-157
19078323-3	1998	Newer inhibitors such as meloxicam, which have been shown to inhibit COX-2 preferentially in vitro, are expected to retain their efficacy while exhibiting decrease toxicity.	Meloxicam	25-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-74
9764845-5	1998	Calphostin C, a potent protein kinase C inhibitor, significantly reduced cholecalciferol-induced PGE2 production by inhibiting cholecalciferol-enhanced COX-2 mRNA and protein expression.	Cholecalciferol	73-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-157
9764845-5	1998	Calphostin C, a potent protein kinase C inhibitor, significantly reduced cholecalciferol-induced PGE2 production by inhibiting cholecalciferol-enhanced COX-2 mRNA and protein expression.	Dinoprostone	97-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-157
9773924-1	1998	In this review, COX-1 and COX-2 proteins have been shown to be homologous in protein structure and ability to synthesize PG, but they have been also shown to be induced differently.	pg	121-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-31
9773924-7	1998	Thus, COX-2-derived PG presumably plays a role in the repair process of gastritis, ulcers, and colitis.	pg	20-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	6-11
9764845-5	1998	Calphostin C, a potent protein kinase C inhibitor, significantly reduced cholecalciferol-induced PGE2 production by inhibiting cholecalciferol-enhanced COX-2 mRNA and protein expression.	Cholecalciferol	127-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-157
19078323-8	1998	These data confirm that preferential COX-2 inhibitors such as meloxicam provide a significant advantage over standard NSAIDs in the treatment of rheumatic diseases.	Meloxicam	62-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-42
9764845-6	1998	These results indicate that (i) 1alpha,25(OH)2D3 does not induce PGE2 biosynthesis in keratinocytes, (ii) cholecalciferol-induced PGE2 production is primarily COX-2 dependent, and (iii) cholecalciferol enhances both COX-2 mRNA and protein expression, via a protein kinase C-dependent mechanism in human keratinocytes.	Cholecalciferol	106-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	159-164
9764845-6	1998	These results indicate that (i) 1alpha,25(OH)2D3 does not induce PGE2 biosynthesis in keratinocytes, (ii) cholecalciferol-induced PGE2 production is primarily COX-2 dependent, and (iii) cholecalciferol enhances both COX-2 mRNA and protein expression, via a protein kinase C-dependent mechanism in human keratinocytes.	Cholecalciferol	106-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	216-221
9764845-6	1998	These results indicate that (i) 1alpha,25(OH)2D3 does not induce PGE2 biosynthesis in keratinocytes, (ii) cholecalciferol-induced PGE2 production is primarily COX-2 dependent, and (iii) cholecalciferol enhances both COX-2 mRNA and protein expression, via a protein kinase C-dependent mechanism in human keratinocytes.	Dinoprostone	130-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	159-164
19078324-2	1998	However, the complex physiologic responses to inflammation and disease suggest that COX-2 inhibition by NSAIDs is an action on only one several interrelated components of the inflammatory response, such as oxygen radical production, nitric oxide synthesis, and heme oxygenase activity, that may affect resolution of inflammation.	Reactive Oxygen Species	206-220	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-89
19078324-2	1998	However, the complex physiologic responses to inflammation and disease suggest that COX-2 inhibition by NSAIDs is an action on only one several interrelated components of the inflammatory response, such as oxygen radical production, nitric oxide synthesis, and heme oxygenase activity, that may affect resolution of inflammation.	Nitric Oxide	233-245	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-89
9722548-7	1998	In addition to cyclooxygenase-1 (COX-1), COX-2 is also constitutively expressed in human HSC, and the use of dexamethasone and of SC-58125, a selective COX-2 inhibitor, revealed that COX-2 accounts for basal COX activity.	1-((4-methylsulfonyl)phenyl)-3-trifluoromethyl-5-(4-fluorophenyl)pyrazole	130-138	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-157
9864833-4	1998	Inhibition of PLA 2- and COX-2-derived pathways of mediators of inflammation (prostanoids and leukotrienes) decreases signs and symptoms of inflammatory synovitis such as joint swelling, tenderness and pain.	Prostaglandins	78-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-30
9864833-4	1998	Inhibition of PLA 2- and COX-2-derived pathways of mediators of inflammation (prostanoids and leukotrienes) decreases signs and symptoms of inflammatory synovitis such as joint swelling, tenderness and pain.	Leukotrienes	94-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-30
11670592-4	1998	The zinc(II) complex Zn(II)(OEBOMe), where OEBOMe is the dianion of octaethylmethoxybiliverdin, is sufficiently stable to be isolated in crystalline form, but the cobalt(II) analogue, Co(II)(OEBOMe), is less stable and has been characterized primarily by (1)H NMR spectroscopy in solution.	Zinc	4-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	184-198
11670592-4	1998	The zinc(II) complex Zn(II)(OEBOMe), where OEBOMe is the dianion of octaethylmethoxybiliverdin, is sufficiently stable to be isolated in crystalline form, but the cobalt(II) analogue, Co(II)(OEBOMe), is less stable and has been characterized primarily by (1)H NMR spectroscopy in solution.	Zinc	21-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	184-198
9722548-7	1998	In addition to cyclooxygenase-1 (COX-1), COX-2 is also constitutively expressed in human HSC, and the use of dexamethasone and of SC-58125, a selective COX-2 inhibitor, revealed that COX-2 accounts for basal COX activity.	1-((4-methylsulfonyl)phenyl)-3-trifluoromethyl-5-(4-fluorophenyl)pyrazole	130-138	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-157
9722548-9	1998	Induction of COX-2 and stimulation of COX activity by ET-1 and TNF-alpha were prevented by sodium salicylate and MG-132, suggesting that activation of NF-kappaB by either factor is needed for stimulation of COX-2.	Sodium Salicylate	91-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
9722548-9	1998	Induction of COX-2 and stimulation of COX activity by ET-1 and TNF-alpha were prevented by sodium salicylate and MG-132, suggesting that activation of NF-kappaB by either factor is needed for stimulation of COX-2.	Sodium Salicylate	91-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	207-212
9722548-9	1998	Induction of COX-2 and stimulation of COX activity by ET-1 and TNF-alpha were prevented by sodium salicylate and MG-132, suggesting that activation of NF-kappaB by either factor is needed for stimulation of COX-2.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	113-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
9722548-9	1998	Induction of COX-2 and stimulation of COX activity by ET-1 and TNF-alpha were prevented by sodium salicylate and MG-132, suggesting that activation of NF-kappaB by either factor is needed for stimulation of COX-2.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	113-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	207-212
9722548-10	1998	Finally, SC-58125 and dexamethasone reduced the growth inhibitory effect of ET-1 and TNF-alpha, indicating that activation of COX-2 is required for inhibition of HSC proliferation.	1-((4-methylsulfonyl)phenyl)-3-trifluoromethyl-5-(4-fluorophenyl)pyrazole	9-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-131
9722548-10	1998	Finally, SC-58125 and dexamethasone reduced the growth inhibitory effect of ET-1 and TNF-alpha, indicating that activation of COX-2 is required for inhibition of HSC proliferation.	Dexamethasone	22-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-131
9783757-6	1998	The Meloxicam Large-scale International Study Safety Assessment (MELISSA) trial reported here was therefore set up to investigate the tolerability of meloxicam, a preferential inhibitor of COX-2, compared to diclofenac.	Meloxicam	150-159	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	189-194
9783757-24	1998	These results may in part reflect the preferential COX-2 selectivity of meloxicam, although the dose and other aspects of tolerability may be important.	Meloxicam	72-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-56
9783758-0	1998	Improvement in gastrointestinal tolerability of the selective cyclooxygenase (COX)-2 inhibitor, meloxicam, compared with piroxicam: results of the Safety and Efficacy Large-scale Evaluation of COX-inhibiting Therapies (SELECT) trial in osteoarthritis.	Meloxicam	96-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-84
9725250-9	1998	The nonselective COX inhibitor indomethacin and the selective COX-2 inhibitor NS-398 strongly inhibited BK-stimulated PGE2 and IL-8 production.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	78-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
9737714-2	1998	A number of agents, including PMA, opsonized bacteria and zymosan, LPS, GM-CSF, TNF-alpha, and fMLP, induced COX-2 protein expression through signaling pathways involving transcription and protein synthesis events.	Tetradecanoylphorbol Acetate	30-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-114
9737714-2	1998	A number of agents, including PMA, opsonized bacteria and zymosan, LPS, GM-CSF, TNF-alpha, and fMLP, induced COX-2 protein expression through signaling pathways involving transcription and protein synthesis events.	Zymosan	58-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-114
9737714-7	1998	Depending on the agonist present, ethanol differentially blocked the stimulated expression of COX-2, raising the possibility that phospholipase D activation might take part in the process of COX-2 induction.	Ethanol	34-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-99
9737714-7	1998	Depending on the agonist present, ethanol differentially blocked the stimulated expression of COX-2, raising the possibility that phospholipase D activation might take part in the process of COX-2 induction.	Ethanol	34-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	191-196
9737714-8	1998	Major COX-2-derived prostanoids synthesized by inflammatory neutrophils were identified by liquid-chromatography and tandem mass-spectrometry as TXA2 and PGE2.	Prostaglandins	20-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	6-11
9737714-8	1998	Major COX-2-derived prostanoids synthesized by inflammatory neutrophils were identified by liquid-chromatography and tandem mass-spectrometry as TXA2 and PGE2.	Dinoprostone	154-158	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	6-11
9737714-9	1998	The agonist-induced synthesis of TXA2 and PGE2 was effectively blocked by cycloheximide and by the specific COX-2 inhibitor NS-398.	Dinoprostone	42-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-113
9737714-9	1998	The agonist-induced synthesis of TXA2 and PGE2 was effectively blocked by cycloheximide and by the specific COX-2 inhibitor NS-398.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	124-130	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-113
9737714-11	1998	They support the concept that, in these cells, the COX-2 isoform is preeminent over COX-1 for the stimulated-production of prostanoids, and also suggest that neutrophil COX-2 displays a distinct profile of expression among circulatory cells.	Prostaglandins	123-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-56
9737714-11	1998	They support the concept that, in these cells, the COX-2 isoform is preeminent over COX-1 for the stimulated-production of prostanoids, and also suggest that neutrophil COX-2 displays a distinct profile of expression among circulatory cells.	Prostaglandins	123-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	169-174
9722671-3	1998	The higher-field doublet and the lower-field broad signals derived from an organic radical and low-spin Co(II) of cob(II)alamin, respectively, were observed.	cob(II)alamin	114-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-110
9722671-7	1998	Upon suicide inactivation with a [15N2]imidazolyl analog, the octet signals due to Co(II) showed superhyperfine splitting into doublets, indicating axial coordination of 5,6-dimethylbenzimidazole to the cobalamin bound to diol dehydratase.	imidazolyl	39-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-89
9722671-7	1998	Upon suicide inactivation with a [15N2]imidazolyl analog, the octet signals due to Co(II) showed superhyperfine splitting into doublets, indicating axial coordination of 5,6-dimethylbenzimidazole to the cobalamin bound to diol dehydratase.	octet	62-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-89
9722671-7	1998	Upon suicide inactivation with a [15N2]imidazolyl analog, the octet signals due to Co(II) showed superhyperfine splitting into doublets, indicating axial coordination of 5,6-dimethylbenzimidazole to the cobalamin bound to diol dehydratase.	5,6-dimethylbenzimidazole	170-195	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-89
9722671-7	1998	Upon suicide inactivation with a [15N2]imidazolyl analog, the octet signals due to Co(II) showed superhyperfine splitting into doublets, indicating axial coordination of 5,6-dimethylbenzimidazole to the cobalamin bound to diol dehydratase.	Vitamin B 12	203-212	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-89
9725250-14	1998	These results suggest that human ASM can be a source of IL-8 and also that endogenous prostanoids, involving both COX-1 and COX-2, have a novel role in mediating BK-induced IL-8 production.	Prostaglandins	86-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	124-129
9725250-9	1998	The nonselective COX inhibitor indomethacin and the selective COX-2 inhibitor NS-398 strongly inhibited BK-stimulated PGE2 and IL-8 production.	Dinoprostone	118-122	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
9736253-1	1998	Cyclooxygenase (COX)-2 mRNA and immunoreactive protein localize to the macula densa and adjacent cortical thick ascending limb in renal cortex, and chronic NaCl restriction increases expression of this enzyme.	Sodium Chloride	156-160	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-22
9825305-2	1998	By a quantitative structure-activity relationship (QSAR) study, the inhibitory activity of a novel series of sulfones and sulfonamides of 1,2-diaryl-4,5-difluorobenzene, against the inducible form of cyclooxygenase (COX-2) was shown to be significantly correlated with the electronic constant (sigma) and some suitable indicator parameters.	Sulfones	109-117	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	216-221
9825305-2	1998	By a quantitative structure-activity relationship (QSAR) study, the inhibitory activity of a novel series of sulfones and sulfonamides of 1,2-diaryl-4,5-difluorobenzene, against the inducible form of cyclooxygenase (COX-2) was shown to be significantly correlated with the electronic constant (sigma) and some suitable indicator parameters.	Sulfonamides	122-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	216-221
9825305-2	1998	By a quantitative structure-activity relationship (QSAR) study, the inhibitory activity of a novel series of sulfones and sulfonamides of 1,2-diaryl-4,5-difluorobenzene, against the inducible form of cyclooxygenase (COX-2) was shown to be significantly correlated with the electronic constant (sigma) and some suitable indicator parameters.	1,2-diaryl-4,5-difluorobenzene	138-168	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	216-221
9736253-2	1998	These findings suggest an integral role for eicosanoids generated by macula densa-associated COX-2 in mediating renin release.	Eicosanoids	44-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-98
9721692-7	1998	PGF2alpha released into the medium during treatment with IL-1beta and the biosynthesis of PGE2 and PGD2 in response to exogenous AA or histamine increased with COX-2 expression, whereas this did not occur in the case of PGI2.	Epoprostenol	220-224	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	160-165
9721692-7	1998	PGF2alpha released into the medium during treatment with IL-1beta and the biosynthesis of PGE2 and PGD2 in response to exogenous AA or histamine increased with COX-2 expression, whereas this did not occur in the case of PGI2.	Dinoprost	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	160-165
9730912-4	1998	This basal expression of COX-2 protein in human gastric mucosa was increased by lipopolysaccharide and phorbol ester, indicating its up-regulation in response to appropriate stimuli.	Phorbol Esters	103-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-30
9730912-8	1998	The data suggest an important role for COX-2-dependent PG production in apparently healthy gastric mucosa and raise the issue of whether selective COX-2 inhibitors might also interfere with physiological PG formation and actions in the stomach.	Prostaglandins	55-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-44
9705326-1	1998	We determined whether resveratrol, a phenolic antioxidant found in grapes and other food products, inhibited phorbol ester (PMA)-mediated induction of COX-2 in human mammary and oral epithelial cells.	Resveratrol	22-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-156
9705326-1	1998	We determined whether resveratrol, a phenolic antioxidant found in grapes and other food products, inhibited phorbol ester (PMA)-mediated induction of COX-2 in human mammary and oral epithelial cells.	Phorbol Esters	109-122	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-156
9705326-1	1998	We determined whether resveratrol, a phenolic antioxidant found in grapes and other food products, inhibited phorbol ester (PMA)-mediated induction of COX-2 in human mammary and oral epithelial cells.	Tetradecanoylphorbol Acetate	124-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-156
9705326-4	1998	Resveratrol suppressed PMA-mediated increases in COX-2 mRNA and protein.	Resveratrol	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-54
9705326-5	1998	Nuclear run-offs revealed increased rates of COX-2 transcription after treatment with PMA, an effect that was inhibited by resveratrol.	Resveratrol	123-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-50
9705326-6	1998	PMA caused about a 6-fold increase in COX-2 promoter activity, which was suppressed by resveratrol.	Tetradecanoylphorbol Acetate	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-43
9705326-6	1998	PMA caused about a 6-fold increase in COX-2 promoter activity, which was suppressed by resveratrol.	Resveratrol	87-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-43
9705326-7	1998	Transient transfections utilizing COX-2 promoter deletion constructs and COX-2 promoter constructs, in which specific enhancer elements were mutagenized, indicated that the effects of PMA and resveratrol were mediated via a cyclic AMP response element.	Tetradecanoylphorbol Acetate	184-187	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-78
9705326-7	1998	Transient transfections utilizing COX-2 promoter deletion constructs and COX-2 promoter constructs, in which specific enhancer elements were mutagenized, indicated that the effects of PMA and resveratrol were mediated via a cyclic AMP response element.	Resveratrol	192-203	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-78
9705326-7	1998	Transient transfections utilizing COX-2 promoter deletion constructs and COX-2 promoter constructs, in which specific enhancer elements were mutagenized, indicated that the effects of PMA and resveratrol were mediated via a cyclic AMP response element.	Cyclic AMP	224-234	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-78
9705326-8	1998	Resveratrol inhibited PMA-mediated activation of protein kinase C. Overexpressing protein kinase C-alpha, ERK1, and c-Jun led to 4.7-, 5.1-, and 4-fold increases in COX-2 promoter activity, respectively.	Resveratrol	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	165-170
9705326-8	1998	Resveratrol inhibited PMA-mediated activation of protein kinase C. Overexpressing protein kinase C-alpha, ERK1, and c-Jun led to 4.7-, 5.1-, and 4-fold increases in COX-2 promoter activity, respectively.	Tetradecanoylphorbol Acetate	22-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	165-170
9705326-11	1998	In addition to the above effects on gene expression, we found that resveratrol also directly inhibited the activity of COX-2.	Resveratrol	67-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-124
9721692-7	1998	PGF2alpha released into the medium during treatment with IL-1beta and the biosynthesis of PGE2 and PGD2 in response to exogenous AA or histamine increased with COX-2 expression, whereas this did not occur in the case of PGI2.	Dinoprostone	90-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	160-165
9721692-7	1998	PGF2alpha released into the medium during treatment with IL-1beta and the biosynthesis of PGE2 and PGD2 in response to exogenous AA or histamine increased with COX-2 expression, whereas this did not occur in the case of PGI2.	Prostaglandin D2	99-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	160-165
9721692-7	1998	PGF2alpha released into the medium during treatment with IL-1beta and the biosynthesis of PGE2 and PGD2 in response to exogenous AA or histamine increased with COX-2 expression, whereas this did not occur in the case of PGI2.	Histamine	135-144	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	160-165
9721692-12	1998	The IL-1beta-induced increase in the release of PGH2 by HUVECs was suppressed by the COX-2-selective inhibitor SC-58125 and correlated with both COX-2 expression and PGIS inactivation.	Prostaglandin H2	48-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-90
9721692-12	1998	The IL-1beta-induced increase in the release of PGH2 by HUVECs was suppressed by the COX-2-selective inhibitor SC-58125 and correlated with both COX-2 expression and PGIS inactivation.	Prostaglandin H2	48-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-150
9721692-12	1998	The IL-1beta-induced increase in the release of PGH2 by HUVECs was suppressed by the COX-2-selective inhibitor SC-58125 and correlated with both COX-2 expression and PGIS inactivation.	1-((4-methylsulfonyl)phenyl)-3-trifluoromethyl-5-(4-fluorophenyl)pyrazole	111-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-90
9721692-12	1998	The IL-1beta-induced increase in the release of PGH2 by HUVECs was suppressed by the COX-2-selective inhibitor SC-58125 and correlated with both COX-2 expression and PGIS inactivation.	1-((4-methylsulfonyl)phenyl)-3-trifluoromethyl-5-(4-fluorophenyl)pyrazole	111-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-150
9705287-11	1998	However, indomethacin treatment decreased the expression of Cox-2 in NaBT-treated cells and significantly increased the expression of 15-LO during NaBT treatment.	Indomethacin	9-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-65
9705287-7	1998	Expression of 15-LO mRNA was dependent on the duration of NaBT treatment, with the highest expression observed between 10 and 24 h. Results from expression and metabolism studies with arachidonic and linoleic acid cells indicated Cox-2 was responsible for the lipid metabolism in control cells, whereas 15-LO was the major enzyme responsible after NaBT induction of apoptosis and cell differentiation.	NABT	58-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	230-235
11670571-4	1998	Germano- and silicotungstates with the alpha-Keggin structure do form complexes with CO(2) when substituted with Co(II), Ni(II), and Mn(II).	Carbon Dioxide	85-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-118
11670571-7	1998	On the other hand, the alpha(1) isomer of the Co(II)-substituted Wells-Dawson anion does not react with CO(2), and neither does the Weakley and Finke cobaltotungstate.	wells-dawson anion	65-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
9705287-11	1998	However, indomethacin treatment decreased the expression of Cox-2 in NaBT-treated cells and significantly increased the expression of 15-LO during NaBT treatment.	NABT	69-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-65
9705287-7	1998	Expression of 15-LO mRNA was dependent on the duration of NaBT treatment, with the highest expression observed between 10 and 24 h. Results from expression and metabolism studies with arachidonic and linoleic acid cells indicated Cox-2 was responsible for the lipid metabolism in control cells, whereas 15-LO was the major enzyme responsible after NaBT induction of apoptosis and cell differentiation.	arachidonic	184-195	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	230-235
9705287-7	1998	Expression of 15-LO mRNA was dependent on the duration of NaBT treatment, with the highest expression observed between 10 and 24 h. Results from expression and metabolism studies with arachidonic and linoleic acid cells indicated Cox-2 was responsible for the lipid metabolism in control cells, whereas 15-LO was the major enzyme responsible after NaBT induction of apoptosis and cell differentiation.	Linoleic Acid	200-213	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	230-235
9705828-6	1998	Inhibition of IL-1 beta induced COX-2 and elevated ICAM-1 expression, an effect reversed by exogenous PGE2.	Dinoprostone	102-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-37
9705287-7	1998	Expression of 15-LO mRNA was dependent on the duration of NaBT treatment, with the highest expression observed between 10 and 24 h. Results from expression and metabolism studies with arachidonic and linoleic acid cells indicated Cox-2 was responsible for the lipid metabolism in control cells, whereas 15-LO was the major enzyme responsible after NaBT induction of apoptosis and cell differentiation.	NABT	348-352	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	230-235
9735147-4	1998	This isoprostane is also produced by the cyclooxygenase enzymes COX1 and COX2.	Isoprostanes	5-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-77
9705828-1	1998	Prostaglandins are well characterised inflammatory mediators, whose formation is regulated by constitutive (COX-1) or inducible (COX-2) isoforms of cyclo-oxygenase.	Prostaglandins	0-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-134
10071386-5	1998	Interference caused by NiII, CoII, CuII, AgI, SeIV, SbIII and HgII could be controlled with a masking solution of thiourea (0.2%)-KI (10%).	Thiourea	114-122	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-33
9692986-3	1998	The d-d electronic transitions of the Co(II)-substituted hexamer give optical signatures of the T to R transition which can be quantified, but the "spectroscopically silent" character of Zn(II) has made previous attempts to describe the Zn(II) species difficult.	Zinc	187-189	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-43
9692986-3	1998	The d-d electronic transitions of the Co(II)-substituted hexamer give optical signatures of the T to R transition which can be quantified, but the "spectroscopically silent" character of Zn(II) has made previous attempts to describe the Zn(II) species difficult.	Zinc	237-239	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-43
9692986-7	1998	Using 4H3N as an indicator, these studies show that both LoA and LoB are made less favorable by the substitution of Co(II) for Zn(II); LoA is increased by 10-fold while LoB by 35-fold, whereas the ligand affinities of the phenolic pockets are unchanged.	4h3n	6-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-122
9692986-7	1998	Using 4H3N as an indicator, these studies show that both LoA and LoB are made less favorable by the substitution of Co(II) for Zn(II); LoA is increased by 10-fold while LoB by 35-fold, whereas the ligand affinities of the phenolic pockets are unchanged.	Zinc	127-133	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-122
9700093-5	1998	The COX inhibitor indomethacin completely prevented the impairment, whereas the selective COX-2 inhibitors NS-398 and nimesulide, protein synthesis inhibitors cycloheximide and actinomycin D, and steroid dexamethasone were all partially effective.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	107-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-95
9698603-3	1998	The LPS-dependent increase in COX activity in AM was attributable to COX-2 because it was inhibited by NS-398 (a COX-2-specific inhibitor).	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	103-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-74
9698603-3	1998	The LPS-dependent increase in COX activity in AM was attributable to COX-2 because it was inhibited by NS-398 (a COX-2-specific inhibitor).	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	103-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-118
9783167-3	1998	Nitrile hydratases are metalloenzymes, incorporating FeIII or CoII ions in thiolate ligand networks where they function as Lewis acids.	thiolate	75-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-66
9783167-3	1998	Nitrile hydratases are metalloenzymes, incorporating FeIII or CoII ions in thiolate ligand networks where they function as Lewis acids.	Lewis Acids	123-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-66
9737091-13	1998	CONCLUSION: Meloxicam inhibited furosemide stimulated renin release, suggesting that in man COX-2 is responsible for prostaglandin synthesis mediating renin release.	Meloxicam	12-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-97
9665771-1	1998	The adsorption of Cd(II) and Co(II) onto kaolinite was investigated at five temperatures between 10 and 70 degreesC.	Kaolin	41-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-35
9665771-2	1998	Adsorption edges showed that both Cd(II) and Co(II) adsorbed onto kaolinite in two stages, separated by a plateau between pH 4 and 7.	Kaolin	66-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-51
9737091-13	1998	CONCLUSION: Meloxicam inhibited furosemide stimulated renin release, suggesting that in man COX-2 is responsible for prostaglandin synthesis mediating renin release.	Furosemide	32-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-97
9737091-13	1998	CONCLUSION: Meloxicam inhibited furosemide stimulated renin release, suggesting that in man COX-2 is responsible for prostaglandin synthesis mediating renin release.	Prostaglandins	117-130	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-97
9856140-2	1998	There are two isoenzymes: COX-1, mostly involved in the production of prostaglandins that are important for the normal function of the organism, such as protection of the stomach, vascular homeostasis and kidney function, and COX-2 which is induced by proinflammatory stimuli and is mostly present in inflammatory cells.	Prostaglandins	70-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	226-231
9990676-10	1998	Ca Ion-stimulated prostanoid formation was uniformly inhibited by COX-2, but not COX-1, inhibitors.	Prostaglandins	18-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-71
9990676-11	1998	IL-1 beta-stimulated PGE2 and PGE2 alpha formation was significantly decreased by both COX-1 and COX-2 inhibitors.	Dinoprostone	21-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
9990676-11	1998	IL-1 beta-stimulated PGE2 and PGE2 alpha formation was significantly decreased by both COX-1 and COX-2 inhibitors.	Dinoprostone	30-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
9715829-8	1998	Nonsteroidal drugs with selective inhibitory activity on the COX-2 isoform should theoretically decrease inflammation while maintaining normal physiologic prostaglandin levels.	Prostaglandins	155-168	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-66
9990676-14	1998	The stimulation of intestinal epithelial cells by Ca Ion seemed to uniformly produce prostanoids through COX-2 activity.	Prostaglandins	85-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-110
18967239-9	1998	The selectivity of the method was demonstrated for the analysis of high purity iron; the accuracy for the determination of Ni(II) and Co(II) was 11 and 3%, respectively while the coefficient of variation was 10 and 8%, respectively.	Iron	79-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-140
18967289-1	1998	A simple, rapid, sensitive and selective method for the microgram detection and spectrophotometric determination of EDTA in water, human urine and detergents, based on its reaction with Co(II) and phosphomolybdic acid at pH 0.5-2.0 is reported.	Edetic Acid	116-120	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	186-192
18967289-2	1998	Absorbance is measured against Co(II)-phosphomolybdic acid reference solution at 750 nm.	phosphomolybdic acid	38-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-36
9722719-11	1998	Cyclic tension force to HPLF also stimulated phenotypic and gene expression of IL-1 beta, PGE2 (COX-2 gene) and tPA.	Dinoprostone	90-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-101
9711054-5	1998	In contrast, the inducible cyclooxygenase (COX-2) produces large amounts of prostanoids, mainly contributing to the pathophysiological process of inflammation.	Prostaglandins	76-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
9711054-6	1998	COX-2 SELECTIVE NSAID: The discovery of the cyclooxgenase-isoenzymes ushered in a new generation of NSAID: A drug with selectivity for COX-2 would inhibit proinflammatory prostanoid synthesis while sparing physiologic prostanoid synthesis.	Prostaglandins	171-181	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
9711054-6	1998	COX-2 SELECTIVE NSAID: The discovery of the cyclooxgenase-isoenzymes ushered in a new generation of NSAID: A drug with selectivity for COX-2 would inhibit proinflammatory prostanoid synthesis while sparing physiologic prostanoid synthesis.	Prostaglandins	171-181	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-140
9711054-6	1998	COX-2 SELECTIVE NSAID: The discovery of the cyclooxgenase-isoenzymes ushered in a new generation of NSAID: A drug with selectivity for COX-2 would inhibit proinflammatory prostanoid synthesis while sparing physiologic prostanoid synthesis.	Prostaglandins	218-228	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
9711054-6	1998	COX-2 SELECTIVE NSAID: The discovery of the cyclooxgenase-isoenzymes ushered in a new generation of NSAID: A drug with selectivity for COX-2 would inhibit proinflammatory prostanoid synthesis while sparing physiologic prostanoid synthesis.	Prostaglandins	218-228	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-140
9711054-8	1998	The experiences with currently used NSAID, which show an increasing incidence of side effects as COX-1 inhibition increases, and studies with the COX-2 selective NSAID salsalate and meloxicam, which have less adverse effects than nonselective COX inhibitors in equivalent antiphlogistic dosage, prove the concept of selective COX-2 inhibition to avoid the NSAID typical side effects.	salicylsalicylic acid	168-177	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	146-151
9688983-2	1998	Cyclooxygenase, the rate-limiting enzyme in prostaglandin synthesis, occurs in two isoforms distinguished on the basis of constitutive (COX-1) or inducible (COX-2) expression patterns in mammalian tissues.	Prostaglandins	44-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	157-162
9758208-3	1998	Recent studies have shown the existence of two isoforms of cyclooxygenase: COX-1, now often referred to as the constitutive form, and COX-2, an inducible form which is the major isoenzyme involved in prostaglandin synthesis in inflammation and other pathological situations.	Prostaglandins	200-213	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-139
9692415-8	1998	COX-2 selective anti-prostaglandins should therefore be as effective as nonselective drugs in inhibition of fetal membrane prostaglandin synthesis.	Prostaglandins	21-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
9692415-8	1998	COX-2 selective anti-prostaglandins should therefore be as effective as nonselective drugs in inhibition of fetal membrane prostaglandin synthesis.	Prostaglandins	21-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
9651867-3	1998	The extractabilities of Cu(II), Ni(II), Co(II) and Ag(I) into the Alg-MC were examined and the highest uptake was found for Cu(II).	alg-mc	66-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-56
9651867-3	1998	The extractabilities of Cu(II), Ni(II), Co(II) and Ag(I) into the Alg-MC were examined and the highest uptake was found for Cu(II).	cu(ii)	124-130	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-56
9680006-3	1998	The purpose of this study was to determine the role of cyclooxygenase II (COX-2) in PGE2 production by Mphi and to investigate the cellular mechanism of COX-2 gene activation.	Dinoprostone	84-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
9680006-9	1998	Both ibuprofen and NS398 inhibited COX-2 mRNA as well as PGE2 production by LPS-stimulated Mphi.	Ibuprofen	5-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40
9680006-9	1998	Both ibuprofen and NS398 inhibited COX-2 mRNA as well as PGE2 production by LPS-stimulated Mphi.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	19-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40
9680006-13	1998	Cyclooxygenase inhibitors reduced PGE2 production by inhibiting both COX-2 mRNA expression and preventing NFkappaB activation.	Dinoprostone	34-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-74
9720310-6	1998	UV and O2 consumption measurements showed that the reaction of Co with water consumed molecular oxygen and generated Co(II).	Oxygen	7-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-123
9720310-6	1998	UV and O2 consumption measurements showed that the reaction of Co with water consumed molecular oxygen and generated Co(II).	Water	71-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-123
9720310-7	1998	Since reaction of Co(II) with H2O2 did not generate any significant amount of .OH radicals, a Co(I) mediated Fenton-like reaction [Co(I) + H2O2-->Co(II) + .OH + OH-] seems responsible for .OH generation.	Hydrogen Peroxide	30-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-24
9720310-7	1998	Since reaction of Co(II) with H2O2 did not generate any significant amount of .OH radicals, a Co(I) mediated Fenton-like reaction [Co(I) + H2O2-->Co(II) + .OH + OH-] seems responsible for .OH generation.	Hydrogen Peroxide	30-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	149-155
9720310-7	1998	Since reaction of Co(II) with H2O2 did not generate any significant amount of .OH radicals, a Co(I) mediated Fenton-like reaction [Co(I) + H2O2-->Co(II) + .OH + OH-] seems responsible for .OH generation.	co(i)	94-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-24
9720310-7	1998	Since reaction of Co(II) with H2O2 did not generate any significant amount of .OH radicals, a Co(I) mediated Fenton-like reaction [Co(I) + H2O2-->Co(II) + .OH + OH-] seems responsible for .OH generation.	co(i)	94-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	149-155
9720310-7	1998	Since reaction of Co(II) with H2O2 did not generate any significant amount of .OH radicals, a Co(I) mediated Fenton-like reaction [Co(I) + H2O2-->Co(II) + .OH + OH-] seems responsible for .OH generation.	co(i)	131-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-24
9720310-7	1998	Since reaction of Co(II) with H2O2 did not generate any significant amount of .OH radicals, a Co(I) mediated Fenton-like reaction [Co(I) + H2O2-->Co(II) + .OH + OH-] seems responsible for .OH generation.	co(i)	131-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	149-155
9720310-7	1998	Since reaction of Co(II) with H2O2 did not generate any significant amount of .OH radicals, a Co(I) mediated Fenton-like reaction [Co(I) + H2O2-->Co(II) + .OH + OH-] seems responsible for .OH generation.	Hydrogen Peroxide	139-143	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-24
9720310-7	1998	Since reaction of Co(II) with H2O2 did not generate any significant amount of .OH radicals, a Co(I) mediated Fenton-like reaction [Co(I) + H2O2-->Co(II) + .OH + OH-] seems responsible for .OH generation.	Hydrogen Peroxide	139-143	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	149-155
9758208-4	1998	Since inhibition of prostaglandin production in tissues where they play a physiological role leads to important side effects, a COX-2 preferential inhibitor would present therapeutical advantages.	Prostaglandins	20-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	128-133
9806002-16	1998	The inducible isoforms of cyclo-oxygenase (COX-2) and nitric oxide synthase (iNOS) play an important role in inflammatory reactions via the production respectively of prostaglandins and nitric oxide.	Prostaglandins	167-181	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
9690866-9	1998	The inhibition elicited by L-NAME on PGE2-release by cytokine-treated astroglial cells was reversed by adding AA (40 microM), showing that the effect of NO on cytokine-dependent PGE2 release occurred at the cyclo-oxygenase (COX) level.	NG-Nitroarginine Methyl Ester	27-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	224-227
9684291-5	1998	Polymerase chain reaction amplification across the COII-tRNA(Lys) intergenic region of these individuals gives different ratios of the three product lengths that are dependent on the concentration of the DNA-binding dye crystal violet.	Gentian Violet	220-234	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-55
9629843-4	1998	We speculate that early induction of COX-2 may fuel tissue damage through prostanoids and free radicals, and delayed induction in remote brain areas may promote reconstitutive processes in the face of tissue scarring and remodeling of the surviving neural networks.	Prostaglandins	74-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-42
9690866-10	1998	Furthermore, the release of PGE2 in cytokine-treated astroglial cells was inhibited by indomethacin (10 microM), a COX inhibitor as well as by preincubating cells with dexamethasone (20 microM), an inhibitor of inducible enzymes, showing that the inducible isoform of COX (COX-2) was involved.	Dexamethasone	168-181	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-118
9690866-10	1998	Furthermore, the release of PGE2 in cytokine-treated astroglial cells was inhibited by indomethacin (10 microM), a COX inhibitor as well as by preincubating cells with dexamethasone (20 microM), an inhibitor of inducible enzymes, showing that the inducible isoform of COX (COX-2) was involved.	Dexamethasone	168-181	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	268-271
9690866-10	1998	Furthermore, the release of PGE2 in cytokine-treated astroglial cells was inhibited by indomethacin (10 microM), a COX inhibitor as well as by preincubating cells with dexamethasone (20 microM), an inhibitor of inducible enzymes, showing that the inducible isoform of COX (COX-2) was involved.	Dinoprostone	28-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-118
9690866-10	1998	Furthermore, the release of PGE2 in cytokine-treated astroglial cells was inhibited by indomethacin (10 microM), a COX inhibitor as well as by preincubating cells with dexamethasone (20 microM), an inhibitor of inducible enzymes, showing that the inducible isoform of COX (COX-2) was involved.	Dexamethasone	168-181	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	273-278
9690866-14	1998	The present experiments demonstrated that the release of PGE2 by astroglial cells pretreated with IL-1beta and TNF-alpha is due to enhanced COX-2 activity via activation of the L-arginine-NO pathway, and this may be relevant to the understanding of the pathophysiological mechanisms underlying neuroimmune disorders.	Dinoprostone	57-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-145
9622066-2	1998	Recent observations suggest that reactive oxygen intermediates play a role in tumor cell growth regulation and expression of the inducible COX, COX-2.	Oxygen	42-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	144-149
9622066-6	1998	Unlike the selective COX inhibitors 1-[(4-methylsulfonyl)phenyl]-3-trifluoromethyl-5-[(4-fluoro)phenyl]pyraz ole (SC 58125) and (2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide (NS 398) that inhibit COX-2 catalytic activity, these antioxidants decreased COX-2 expression at the transcriptional level.	1-((4-methylsulfonyl)phenyl)-3-trifluoromethyl-5-(4-fluorophenyl)pyrazole	36-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	200-205
9690866-10	1998	Furthermore, the release of PGE2 in cytokine-treated astroglial cells was inhibited by indomethacin (10 microM), a COX inhibitor as well as by preincubating cells with dexamethasone (20 microM), an inhibitor of inducible enzymes, showing that the inducible isoform of COX (COX-2) was involved.	Dinoprostone	28-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	268-271
9690866-14	1998	The present experiments demonstrated that the release of PGE2 by astroglial cells pretreated with IL-1beta and TNF-alpha is due to enhanced COX-2 activity via activation of the L-arginine-NO pathway, and this may be relevant to the understanding of the pathophysiological mechanisms underlying neuroimmune disorders.	Arginine	177-187	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-145
9690866-10	1998	Furthermore, the release of PGE2 in cytokine-treated astroglial cells was inhibited by indomethacin (10 microM), a COX inhibitor as well as by preincubating cells with dexamethasone (20 microM), an inhibitor of inducible enzymes, showing that the inducible isoform of COX (COX-2) was involved.	Dinoprostone	28-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	273-278
9690866-10	1998	Furthermore, the release of PGE2 in cytokine-treated astroglial cells was inhibited by indomethacin (10 microM), a COX inhibitor as well as by preincubating cells with dexamethasone (20 microM), an inhibitor of inducible enzymes, showing that the inducible isoform of COX (COX-2) was involved.	Indomethacin	87-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-118
9660336-3	1998	Recently, two isozymes of cyclooxygenase, COX-1 and COX-2, which are key enzymes in prostaglandin (PG) biosynthesis, were identified and COX-2 was induced following the activation of cells by a variety of proinflammatory agents.	Prostaglandins	84-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-57
15810290-1	1998	In PEG-Eriochrome cyanine R-(NH4)2SO4 system the liquid-liquid extraction behaviour of Co(II) and Ni(II) without organic solvents was investigated.	Polyethylene Glycols	3-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-93
15810290-1	1998	In PEG-Eriochrome cyanine R-(NH4)2SO4 system the liquid-liquid extraction behaviour of Co(II) and Ni(II) without organic solvents was investigated.	eriochrome cyanine r-(nh4)2so4	7-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-93
9660336-3	1998	Recently, two isozymes of cyclooxygenase, COX-1 and COX-2, which are key enzymes in prostaglandin (PG) biosynthesis, were identified and COX-2 was induced following the activation of cells by a variety of proinflammatory agents.	Prostaglandins	84-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-142
9660336-3	1998	Recently, two isozymes of cyclooxygenase, COX-1 and COX-2, which are key enzymes in prostaglandin (PG) biosynthesis, were identified and COX-2 was induced following the activation of cells by a variety of proinflammatory agents.	Prostaglandins	99-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-57
9660336-3	1998	Recently, two isozymes of cyclooxygenase, COX-1 and COX-2, which are key enzymes in prostaglandin (PG) biosynthesis, were identified and COX-2 was induced following the activation of cells by a variety of proinflammatory agents.	Prostaglandins	99-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-142
9660336-9	1998	When NS-398, a selective COX-2 inhibitor, was added to the medium, PGE2 synthesis increased by tension force was completely inhibited.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	5-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-30
9660336-9	1998	When NS-398, a selective COX-2 inhibitor, was added to the medium, PGE2 synthesis increased by tension force was completely inhibited.	Dinoprostone	67-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-30
9660336-10	1998	These results indicate that tension force induces COX-2 in human PDL cells and that this induction is responsible for the augmentation of PGE2 production stimulated by tension force.	Dinoprostone	138-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-55
9582321-3	1998	Our experiments demonstrate that overexpression of DeltaMEKK1 (a constitutively active truncation mutant of MEKK1 containing the C-terminal 324 amino acids) increases Cox-2 expression and PGE2 production which is completely blocked by SC68376, a pharmacologic inhibitor of p38 MAPK.	2-methyl-4-phenyl-(4-pyridyl)oxazole	235-242	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	167-172
9630216-2	1998	COX-2-overexpressing cells produce prostaglandins, proangiogenic factors, and stimulate both endothelial migration and tube formation, while control cells have little activity.	Prostaglandins	35-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
9630216-3	1998	The effect is inhibited by antibodies to combinations of angiogenic factors, by NS-398 (a selective COX-2 inhibitor), and by aspirin.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	80-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-105
9582321-9	1998	Together, this data suggests a potential role for the MEKK1 --> SEK1/MKK4 --> p38 MAPK -->--> Cox-2 cascade linking members of the MAPK pathway with prostaglandin biosynthesis.	Prostaglandins	161-174	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-111
9615719-5	1998	By Northern analysis, COX-2 mRNA was induced by EGF and phorbol ester.	Phorbol Esters	56-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-27
9633531-9	1998	In summary, we demonstrate that the potentiation of PGE2 production by TGF-beta 1 in IL-1 beta and TNF-alpha-treated fibroblasts is the result of transcriptional stimulation of the Cox-2 gene by IL-1 beta and TNF-alpha and the stabilization of the resulting transcripts by TGF-beta 1.	Dinoprostone	52-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	181-186
29711243-1	1998	The templating effect of the tetrafluoroborate ion leads to assembly of four CoII ions and six bridging ligands around this anion to give a tetrahedral complex with a bridging ligand along each edge and the anion trapped in the central cavity (shown below).	fluoroboric acid	29-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-81
11670380-4	1998	These organometallic Co(III) complexes underwent facile oxidative migration of the Co-bound vinyl group to a porphyrin pyrrole nitrogen when treated with Fe(III) salts or HClO(4) to provide moderate to good yields of Co(II) vinylene-N,N"-linked multi(porphyrin) complexes.	porphyrin pyrrole	109-126	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	217-223
11670380-4	1998	These organometallic Co(III) complexes underwent facile oxidative migration of the Co-bound vinyl group to a porphyrin pyrrole nitrogen when treated with Fe(III) salts or HClO(4) to provide moderate to good yields of Co(II) vinylene-N,N"-linked multi(porphyrin) complexes.	Nitrogen	127-135	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	217-223
11670380-4	1998	These organometallic Co(III) complexes underwent facile oxidative migration of the Co-bound vinyl group to a porphyrin pyrrole nitrogen when treated with Fe(III) salts or HClO(4) to provide moderate to good yields of Co(II) vinylene-N,N"-linked multi(porphyrin) complexes.	Porphyrins	251-261	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	217-223
11672104-0	1998	Formal Synthesis of 3-Deoxy-D-manno-2-Octulosonic Acid (KDO) via a Highly Double-Stereoselective Hetero Diels-Alder Reaction Directed by a (Salen)Co(II) Catalyst and Chiral Diene.	3-deoxy-manno-oct-2-ulopyranosonic acid	20-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	146-151
11672104-0	1998	Formal Synthesis of 3-Deoxy-D-manno-2-Octulosonic Acid (KDO) via a Highly Double-Stereoselective Hetero Diels-Alder Reaction Directed by a (Salen)Co(II) Catalyst and Chiral Diene.	2-keto-3-deoxyoctonate	56-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	146-151
11672104-0	1998	Formal Synthesis of 3-Deoxy-D-manno-2-Octulosonic Acid (KDO) via a Highly Double-Stereoselective Hetero Diels-Alder Reaction Directed by a (Salen)Co(II) Catalyst and Chiral Diene.	diene	173-178	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	146-151
11672104-1	1998	This paper presents a formal total synthesis of 3-deoxy-D-manno-2-octulosonic acid (KDO) based on a highly double-stereoselective hetero Diels-Alder reaction between an electron-rich diene and ethyl glyoxylate catalyzed by (Salen)Co(II) complex, a new catalyst for Diels-Alder reactions.	3-deoxy-manno-oct-2-ulopyranosonic acid	48-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	230-235
11672104-1	1998	This paper presents a formal total synthesis of 3-deoxy-D-manno-2-octulosonic acid (KDO) based on a highly double-stereoselective hetero Diels-Alder reaction between an electron-rich diene and ethyl glyoxylate catalyzed by (Salen)Co(II) complex, a new catalyst for Diels-Alder reactions.	2-keto-3-deoxyoctonate	84-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	230-235
9536016-7	1998	Pretreatment with NS398 (COX-2 inhibitor) significantly decreased ROS generation indicating the involvement of COX-2 in KCN-induced oxidant generation.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	18-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-30
9536016-7	1998	Pretreatment with NS398 (COX-2 inhibitor) significantly decreased ROS generation indicating the involvement of COX-2 in KCN-induced oxidant generation.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	18-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	111-116
9536016-7	1998	Pretreatment with NS398 (COX-2 inhibitor) significantly decreased ROS generation indicating the involvement of COX-2 in KCN-induced oxidant generation.	Reactive Oxygen Species	66-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-30
9536016-7	1998	Pretreatment with NS398 (COX-2 inhibitor) significantly decreased ROS generation indicating the involvement of COX-2 in KCN-induced oxidant generation.	Potassium Cyanide	120-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-30
9536016-7	1998	Pretreatment with NS398 (COX-2 inhibitor) significantly decreased ROS generation indicating the involvement of COX-2 in KCN-induced oxidant generation.	Potassium Cyanide	120-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	111-116
9536016-11	1998	Pretreatment with inhibitors of protein kinase C, phospholipase A2 or COX, LOX, COX-2 partially blocked KCN-induced formation of thiobarbituric acid reactive substance, whereas coincubation of L-NAME with the inhibitors decreased lipid peroxidation by 60 to 90%.	Potassium Cyanide	104-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-85
9536016-11	1998	Pretreatment with inhibitors of protein kinase C, phospholipase A2 or COX, LOX, COX-2 partially blocked KCN-induced formation of thiobarbituric acid reactive substance, whereas coincubation of L-NAME with the inhibitors decreased lipid peroxidation by 60 to 90%.	thiobarbituric acid	129-148	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-85
9536016-13	1998	These findings show that activation of phospholipase A2 and subsequent metabolism of arachidonic acid by the COX-2 and LOX pathways and NOS contribute to cyanide-induced ROS production.	Arachidonic Acid	85-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-114
9536016-13	1998	These findings show that activation of phospholipase A2 and subsequent metabolism of arachidonic acid by the COX-2 and LOX pathways and NOS contribute to cyanide-induced ROS production.	Cyanides	154-161	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-114
9536016-13	1998	These findings show that activation of phospholipase A2 and subsequent metabolism of arachidonic acid by the COX-2 and LOX pathways and NOS contribute to cyanide-induced ROS production.	Reactive Oxygen Species	170-173	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-114
9562240-10	1998	These observations indicate that, (1) while either ceramide or IL-1 rapidly induced COX-2 mRNA, COX-2 protein only accumulated in IL-1 treated cells after a delay of 6-7 h, (2) IL-1-induced PGE2 synthesis required both COX-2 and cPLA2 protein synthesis and, (3) ceramide enhanced (temporally and quantitatively) IL-1-induced COX-2 protein	Ceramides	51-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-89
11670322-13	1998	The ability of the Fe(II) and Co(II) analogues of 19 to bind ligands such as O(2)(-) or S(2)(-) and O(2), respectively, in the "pocket" of the complex is described, and the products have been characterized.	o(2)(-)	77-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-36
11670322-13	1998	The ability of the Fe(II) and Co(II) analogues of 19 to bind ligands such as O(2)(-) or S(2)(-) and O(2), respectively, in the "pocket" of the complex is described, and the products have been characterized.	o(2)	77-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-36
9515807-11	1998	This is the first description of functional COX-2 expression by NSCLC cells and the definition of a pathway whereby tumor COX-2 expression and a high level of PGE2 production mediate profound alteration in cytokine balance in the lung cancer microenvironment.	Dinoprostone	159-163	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-49
9524553-3	1998	Cyclic voltammetry of the complexes in MeCN reveals quasi-reversible behaviour for the Co(III)/Co(II) couple, with E1/2 increasing in the order DCE < DEE approximately BCE < BEE.	acetonitrile	39-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-101
9524553-3	1998	Cyclic voltammetry of the complexes in MeCN reveals quasi-reversible behaviour for the Co(III)/Co(II) couple, with E1/2 increasing in the order DCE < DEE approximately BCE < BEE.	ethylene dichloride	144-147	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-101
9524553-4	1998	In MeCN/H2O electrochemical reduction is irreversible, indicating rapid substitution of H2O into the coordination sphere of the Co(II) intermediate.	acetonitrile	3-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	128-134
9524553-4	1998	In MeCN/H2O electrochemical reduction is irreversible, indicating rapid substitution of H2O into the coordination sphere of the Co(II) intermediate.	Water	8-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	128-134
9524553-4	1998	In MeCN/H2O electrochemical reduction is irreversible, indicating rapid substitution of H2O into the coordination sphere of the Co(II) intermediate.	Water	88-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	128-134
9524553-8	1998	This reaction is not inhibited by O2, indicating that reoxidation of the Co(II) intermediate by O2 is not rapid enough to compete with ligand dissociation.	Oxygen	96-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-79
9610372-6	1998	A sequence that the calcium influx activates PkA which, in turn, activates c-fos and COX-2 transcription resulting in the production of proteins such as IGF-I and osteocalcin.	Calcium	20-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-90
9626023-9	1998	Inhibitory effects of NSAIDs on gastric prostaglandin E2 synthesis correlated with COX-1 inhibitory potency in blood (P < 0.001) and with COX-1 selectivity (P < 0.01), but not with COX-2 inhibitory potency.	Dinoprostone	40-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	187-192
9626023-10	1998	Even COX-2 "selective" NSAIDs still had sufficient COX-1 activity to cause potent inhibitory effects on gastric prostaglandin E2 synthesis at concentrations achieved in vivo.	Dinoprostone	112-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	5-10
9568691-9	1998	In human islets, the proteasome inhibitor MG 132 also inhibited the formation of the products of iNOS and COX-2 enzyme activity, nitrite, and PGE2, respectively.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	42-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-111
9562240-3	1998	The present study was undertaken to determine the mechanism(s) by which ceramide and IL-1 interact to enhance PGE2 production by examining their respective effects on the rate-limiting enzymes in PGE2 synthesis, cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2), and cytosolic phospholipase A2 (cPLA2).	Ceramides	72-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	256-261
9562240-5	1998	Conversely, COX-2 mRNA was barely detectable in untreated cells but within 2 h, ceramide or IL-1 alone induced a 5 and 20 fold increase in COX-2 mRNA, respectively.	Ceramides	80-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-17
9562240-5	1998	Conversely, COX-2 mRNA was barely detectable in untreated cells but within 2 h, ceramide or IL-1 alone induced a 5 and 20 fold increase in COX-2 mRNA, respectively.	Ceramides	80-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-144
9562240-7	1998	Ceramide however, reduced the length of time required for IL-1 to induce COX-2 protein accumulation and increased COX-2 protein accumulation.	Ceramides	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-78
9562240-7	1998	Ceramide however, reduced the length of time required for IL-1 to induce COX-2 protein accumulation and increased COX-2 protein accumulation.	Ceramides	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-119
9572320-8	1998	It has been reported that the selective COX-2 inhibitor L-745,337 has a reduced liability for gastrointestinal ulceration.	l-745	56-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
9515807-2	1998	We hypothesized that a high level of PGE2 production by lung tumor cells is dependent on tumor cyclooxygenase (COX)-2 expression.	Dinoprostone	37-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-117
9515807-4	1998	Reversal of IL-1beta-induced PGE2 production in A549 cells was achieved by specific pharmacological or antisense oligonucleotide inhibition of COX-2 activity or expression.	Dinoprostone	29-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	143-148
9515807-4	1998	Reversal of IL-1beta-induced PGE2 production in A549 cells was achieved by specific pharmacological or antisense oligonucleotide inhibition of COX-2 activity or expression.	Oligonucleotides	113-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	143-148
9515807-8	1998	Furthermore, specific inhibition of A549 COX-2 reversed the tumor-derived PGE2-dependent inhibition of macrophage IL-12 production when whole blood was cultured in tumor supernatants.	Dinoprostone	74-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-46
9515564-1	1998	Aspirin and conventional nonsteroidal anti-inflammatory drugs are nonselective inhibitors of cyclooxygenase-1 (COX-1) and COX-2 enzymes.	Aspirin	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-127
9515564-2	1998	Two classes of selective COX-2 inhibitors: (1) sulfonamides, such as L-745,337, and (2) tricyclic methyl sulfone derivatives, such as SC58125, have been developed.	Sulfonamides	47-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-30
9515564-2	1998	Two classes of selective COX-2 inhibitors: (1) sulfonamides, such as L-745,337, and (2) tricyclic methyl sulfone derivatives, such as SC58125, have been developed.	l-745	69-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-30
9515564-2	1998	Two classes of selective COX-2 inhibitors: (1) sulfonamides, such as L-745,337, and (2) tricyclic methyl sulfone derivatives, such as SC58125, have been developed.	tricyclic methyl sulfone	88-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-30
9515564-2	1998	Two classes of selective COX-2 inhibitors: (1) sulfonamides, such as L-745,337, and (2) tricyclic methyl sulfone derivatives, such as SC58125, have been developed.	1-((4-methylsulfonyl)phenyl)-3-trifluoromethyl-5-(4-fluorophenyl)pyrazole	134-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-30
9543076-1	1998	BACKGROUND: Cyclo-oxygenases 1 (Cox-1) and 2 (Cox-2) catalyse the conversion of arachidonic acid to prostaglandin endoperoxides, leading to the formation of prostaglandin and thromboxane mediators of inflammation.	Arachidonic Acid	80-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
9473245-4	1998	We found that MSU crystals, but not calcium pyrophosphate dihydrate (CPPD) crystals, induced COX-2, which correlated with the synthesis of prostaglandin E2 (PGE2) and thromboxane A2 (TXA2).	Uric Acid	14-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-98
9473245-6	1998	Inhibition of tyrosine phosphorylation, by herbimycin A, blocked crystal-induced COX-2.	Tyrosine	14-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-86
9473245-6	1998	Inhibition of tyrosine phosphorylation, by herbimycin A, blocked crystal-induced COX-2.	herbimycin	43-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-86
9473245-7	1998	Similarly, an inhibitor of the p38 mitogen-activated protein kinase, SB 203580, inhibited the stimulation of COX-2.	SB 203580	69-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-114
9473245-8	1998	Colchicine inhibited crystal-induced COX-2.	Colchicine	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-42
9473245-10	1998	Taken together, these results implicate COX-2 in the development of MSU-induced inflammation.	Uric Acid	68-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
9543076-1	1998	BACKGROUND: Cyclo-oxygenases 1 (Cox-1) and 2 (Cox-2) catalyse the conversion of arachidonic acid to prostaglandin endoperoxides, leading to the formation of prostaglandin and thromboxane mediators of inflammation.	Prostaglandin Endoperoxides	100-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
9543076-1	1998	BACKGROUND: Cyclo-oxygenases 1 (Cox-1) and 2 (Cox-2) catalyse the conversion of arachidonic acid to prostaglandin endoperoxides, leading to the formation of prostaglandin and thromboxane mediators of inflammation.	Prostaglandins	100-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
9543076-1	1998	BACKGROUND: Cyclo-oxygenases 1 (Cox-1) and 2 (Cox-2) catalyse the conversion of arachidonic acid to prostaglandin endoperoxides, leading to the formation of prostaglandin and thromboxane mediators of inflammation.	Thromboxanes	175-186	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
9467571-5	1998	COX-2 activity was induced by IL-1 beta (1 ng/mL); conversion of exogenous arachidonic acid to PGF2 alpha increased from 2.6 +/- 0.6 ng/well (mean +/- SEM; n = 6) to 22.2 +/- 5.6 ng, but was completely blocked (2.8 +/- 0.7 ng/well) by NS-398, a specific COX-2 inhibitor.	Dinoprost	95-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
18967073-0	1998	Sulphuric acid influence on liquid-liquid extraction of Co(II) and Zn(II) by MIBK from NH(4)SCN medium.	sulfuric acid	0-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-62
18967073-0	1998	Sulphuric acid influence on liquid-liquid extraction of Co(II) and Zn(II) by MIBK from NH(4)SCN medium.	scn medium	92-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-62
18967073-1	1998	Liquid-liquid extraction of Co(II) and Zn(II) by methylisobutylcetone (MIBK) has been studied systematically from NH(4)SCN/H(2)SO(4) media.	methyl isobutyl ketone	49-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-34
18967073-2	1998	The influence of sulphuric acid concentration on the percentage of extraction of Co(II) and Zn(II) has been discussed.	sulfuric acid	17-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-87
18967073-4	1998	Thus, it is possible to have a separation of Zn(II) of Co(II) when [NH(4)SCN] is 0.5 mol l(-1) and [H(2)SO(4)] is about 2 mol l(-1).	Zinc	45-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-61
9467571-5	1998	COX-2 activity was induced by IL-1 beta (1 ng/mL); conversion of exogenous arachidonic acid to PGF2 alpha increased from 2.6 +/- 0.6 ng/well (mean +/- SEM; n = 6) to 22.2 +/- 5.6 ng, but was completely blocked (2.8 +/- 0.7 ng/well) by NS-398, a specific COX-2 inhibitor.	Dinoprost	95-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	254-259
9467571-5	1998	COX-2 activity was induced by IL-1 beta (1 ng/mL); conversion of exogenous arachidonic acid to PGF2 alpha increased from 2.6 +/- 0.6 ng/well (mean +/- SEM; n = 6) to 22.2 +/- 5.6 ng, but was completely blocked (2.8 +/- 0.7 ng/well) by NS-398, a specific COX-2 inhibitor.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	235-241	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
9467571-6	1998	Undetectable in quiescent stromal cells, messenger ribonucleic acid for COX-2 was induced 30 min after IL-1 beta treatment, reached a maximum at 4 h, and decreased after 15 h. Protein synthesis was not required for induction of the COX-2 gene, as it was blocked by actinomycin D but not by cycloheximide.	Dactinomycin	265-278	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
9467571-6	1998	Undetectable in quiescent stromal cells, messenger ribonucleic acid for COX-2 was induced 30 min after IL-1 beta treatment, reached a maximum at 4 h, and decreased after 15 h. Protein synthesis was not required for induction of the COX-2 gene, as it was blocked by actinomycin D but not by cycloheximide.	Cycloheximide	290-303	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
9553452-2	1998	Meloxicam is a new oxicam which has a low COX-2/COX-1 ratio, i.e. it has an inhibitory effect focused on the inflammatory proteins (COX-2) with relative saving of the homeostatic proteins (COX-1).	Meloxicam	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47
9570560-6	1998	Expression of COX-2 in stimulated PMNs was paralleled by secretion of PGE2.	Dinoprostone	70-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
9570560-7	1998	The release of PGE2 was blocked by a selective nonsteroidal inhibitor of COX-2, indicating that the enzyme is responsible for the prostanoids produced, and was inhibited by dexamethasone.	Dinoprostone	15-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-78
9570560-7	1998	The release of PGE2 was blocked by a selective nonsteroidal inhibitor of COX-2, indicating that the enzyme is responsible for the prostanoids produced, and was inhibited by dexamethasone.	Prostaglandins	130-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-78
9570560-7	1998	The release of PGE2 was blocked by a selective nonsteroidal inhibitor of COX-2, indicating that the enzyme is responsible for the prostanoids produced, and was inhibited by dexamethasone.	Dexamethasone	173-186	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-78
9553452-2	1998	Meloxicam is a new oxicam which has a low COX-2/COX-1 ratio, i.e. it has an inhibitory effect focused on the inflammatory proteins (COX-2) with relative saving of the homeostatic proteins (COX-1).	Meloxicam	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-137
9553452-2	1998	Meloxicam is a new oxicam which has a low COX-2/COX-1 ratio, i.e. it has an inhibitory effect focused on the inflammatory proteins (COX-2) with relative saving of the homeostatic proteins (COX-1).	oxicam	3-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47
9553452-2	1998	Meloxicam is a new oxicam which has a low COX-2/COX-1 ratio, i.e. it has an inhibitory effect focused on the inflammatory proteins (COX-2) with relative saving of the homeostatic proteins (COX-1).	oxicam	3-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-137
9417062-8	1998	At high pH the NMR spectrum of the Co(II)-M121H azurin experiences an additional transition, which is not observed in the case of the Cu(II) protein.	cu(ii)	134-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40
9443907-1	1998	Cyclooxygenase catalyses a key step in prostaglandin biosynthesis, and recent work suggests that one isoenzyme, COX-2, has important roles in early stages of pregnancy; it also appears to be involved in the somewhat analogous process of colon tumor formation and spread.	Prostaglandins	39-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-117
9443418-3	1998	To explore the biochemical mechanisms involved in these effects, we have evaluated the role of COX-2-derived eicosanoid products on programmed cell death in human colon cancer cells.	Eicosanoids	109-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-100
9443418-5	1998	Treatment with a highly selective COX-2 inhibitor (SC-58125) decreases colony formation in monolayer culture and this growth inhibition was reversed by treatment with PGE2.	1-((4-methylsulfonyl)phenyl)-3-trifluoromethyl-5-(4-fluorophenyl)pyrazole	51-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-39
9443418-5	1998	Treatment with a highly selective COX-2 inhibitor (SC-58125) decreases colony formation in monolayer culture and this growth inhibition was reversed by treatment with PGE2.	Dinoprostone	167-171	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-39
9417062-0	1998	The dynamic properties of the M121H azurin metal site as studied by NMR of the paramagnetic Cu(II) and Co(II) metalloderivatives.	Metals	43-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-109
9417062-1	1998	The M121H azurin mutant in solution presents various species in equilibrium that can be detected and studied by 1H NMR of the Cu(II) and Co(II) paramagnetic metalloderivatives.	Hydrogen	7-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-143
11670255-7	1998	The formation and the structure of a novel chelating amido(thiolato) complex (PPh(4))(2)[Co(II){S-2,6-(CF(3)CONH)(2)C(6)H(3)}(2)(S-2-CF(3)CONH-6-CF(3)CONC(6)H(3))].Et(2)O (9) are also described.	amido(thiolato)	53-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-95
9461646-1	1998	A radiochemical enzyme assay for studying cyclooxygenase (COX)-catalyzed prostaglandin biosynthesis in vitro was optimized with respect to both COX-1 and COX-2 activity.	Prostaglandins	73-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	154-159
9433878-6	1998	RESULTS: Both the T2 and EA extracts inhibited PGE2 synthesis in the LPS-stimulated HM, RASF, and HFF cells, which was reflected by a marked suppression in the levels of mRNA for COX-2.	Dinoprostone	47-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	179-184
9433878-8	1998	Triptolide also inhibited LPS-stimulated induction of COX-2 mRNA and synthesis of PGE2, at the same inhibitory concentration as seen with the EA extract.	triptolide	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-59
9433878-10	1998	CONCLUSION: The data indicate that both the T2 and EA extracts of TWHF, as well as the triptolide component, inhibit PGE2 production in a variety of human cells by blocking the up-regulation of COX-2.	triptolide	87-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	194-199
9433878-10	1998	CONCLUSION: The data indicate that both the T2 and EA extracts of TWHF, as well as the triptolide component, inhibit PGE2 production in a variety of human cells by blocking the up-regulation of COX-2.	Dinoprostone	117-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	194-199
9561441-10	1998	Other roles for COX-2 inhibitors will surely be found in the next few years, for prostaglandin formation is under strong control in organs such as the kidney, lungs and uterus.	Prostaglandins	81-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-21
9872495-6	1998	Furthermore, in situations in which there is inflammation or ulceration in the GI tract, COX-2 produces prostaglandins that are essential for repair.	Prostaglandins	104-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-94
9461646-9	1998	The optimization procedure resulted in a considerable reduction of the amount of enzyme required for adequate prostglandin biosynthesis and a reliable method suited to evaluate natural products on inhibition of COX-2-catalyzed prostaglandin biosynthesis, as well as on COX-1.	Prostaglandins	227-240	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	211-216
9932449-4	1998	PAF also couples synaptic events with gene expression by stimulating a FOS/JUN/AP-1 transcriptional signaling system, as well as transcription of COX-2 (inducible prostaglandin synthase).	Prostaglandins	163-176	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	146-151
9820127-0	1998	Dual effects of nimesulide, a COX-2 inhibitor, in human platelets.	nimesulide	16-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-35
9820127-2	1998	Since nimesulide is considered to be a selective inhibitor of COX-2, it has not been studied in detail in relation to its mechanistic effects on platelets, which express COX-1.	nimesulide	6-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
9927229-2	1998	Cyclooxygenase (COX), which catalyzes the conversion of arachidonic acid to prostanoids exists in two isoforms, COX-1 and COX-2.	Arachidonic Acid	56-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-127
9927229-2	1998	Cyclooxygenase (COX), which catalyzes the conversion of arachidonic acid to prostanoids exists in two isoforms, COX-1 and COX-2.	Prostaglandins	76-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-127
9927229-3	1998	The purpose of this study was to determine the relative contributions of COX-1 and COX-2 in the production of prostanoids by human intestinal smooth muscle (HISM) cells when stimulated by interleukin-1beta (IL-1beta) and lipopolysaccharide (LPS).	Prostaglandins	110-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
9927229-15	1998	The COX-1 and COX-2 inhibitors decreased both basal and IL-1beta and LPS stimulated prostanoid release.	Prostaglandins	84-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
9927229-17	1998	3H-thymidine incorporation, stimulated by serum, was inhibited by both COX-1 and COX-2 inhibitors.	3h-thymidine	0-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-86
9927229-18	1998	This study suggests that the prostanoid response stimulated by proinflammatory agents of gut-derived smooth muscle cells appears to be mediated by both COX-1 and COX-2 enzymes.	Prostaglandins	29-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	162-167
9932449-11	1998	BN 50730, a potent intracellular PAF antagonist, blocks COX-2 induction.	BN 50730	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-61
9932449-12	1998	COX-2 transcription and protein expression are upregulated in the hippocampus in kainic acid induced epileptogenesis.	Kainic Acid	81-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
9932449-13	1998	There is a selectively elevated induction of COX-2 (72-fold) by kainic acid preceding neuronal cell death.	Kainic Acid	64-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-50
9469643-3	1997	Either M-5011 or ketoprofen potently inhibited prostaglandin (PG) E2 production by cyclooxygenase (COX)-2 from exogenous AA in interleukin-1beta (IL-1beta)-stimulated cells.	2-(4-(3-methyl-2-thienyl)phenyl)propionic acid	7-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-105
9435567-11	1997	Conversion of increased arachidonic acid release to PGE2 by COX-1 is mainly involved in the short-term effect, whereas B2 receptor-related COX-2 induction is important in the long-term PGE2 release.	Dinoprostone	185-189	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-144
9469643-3	1997	Either M-5011 or ketoprofen potently inhibited prostaglandin (PG) E2 production by cyclooxygenase (COX)-2 from exogenous AA in interleukin-1beta (IL-1beta)-stimulated cells.	Ketoprofen	17-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-105
9469643-3	1997	Either M-5011 or ketoprofen potently inhibited prostaglandin (PG) E2 production by cyclooxygenase (COX)-2 from exogenous AA in interleukin-1beta (IL-1beta)-stimulated cells.	Dinoprostone	47-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-105
9427063-1	1997	Most available nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit both the constitutive cyclooxygenase-1 (COX-1) and the inducible cyclooxygenase-2 (COX-2), resulting in inhibition of prostaglandin (PG) and thromboxane (TX) biosynthesis.	Prostaglandins	187-200	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-157
9427063-1	1997	Most available nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit both the constitutive cyclooxygenase-1 (COX-1) and the inducible cyclooxygenase-2 (COX-2), resulting in inhibition of prostaglandin (PG) and thromboxane (TX) biosynthesis.	Prostaglandins	202-204	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-157
9427063-1	1997	Most available nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit both the constitutive cyclooxygenase-1 (COX-1) and the inducible cyclooxygenase-2 (COX-2), resulting in inhibition of prostaglandin (PG) and thromboxane (TX) biosynthesis.	Thromboxanes	210-221	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-157
9427063-4	1997	Its pharmacological profile (better inhibition of PG synthesis in inflammatory areas than in gastric mucosa), suggested that it might be a selective inhibitor of COX-2.	Prostaglandins	50-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	162-167
9427063-5	1997	In several in vitro assays using either purified COX-2 and COX-1 preparations or cell preparations (both from animal and human origins) expressing COX-1 or COX-2, ten out of eleven different groups have demonstrated that nimesulide selectively inhibits COX-2.	nimesulide	221-231	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-54
9427063-5	1997	In several in vitro assays using either purified COX-2 and COX-1 preparations or cell preparations (both from animal and human origins) expressing COX-1 or COX-2, ten out of eleven different groups have demonstrated that nimesulide selectively inhibits COX-2.	nimesulide	221-231	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	156-161
9427063-5	1997	In several in vitro assays using either purified COX-2 and COX-1 preparations or cell preparations (both from animal and human origins) expressing COX-1 or COX-2, ten out of eleven different groups have demonstrated that nimesulide selectively inhibits COX-2.	nimesulide	221-231	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	156-161
9427063-7	1997	Moreover, an in vivo whole blood assay performed on healthy volunteers demonstrated a significant fall in COX-2 PGE2 production without any effect on COX-1 TXB2 production in subjects treated with nimesulide (100 mg b.i.d.	Dinoprostone	112-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-111
9427063-7	1997	Moreover, an in vivo whole blood assay performed on healthy volunteers demonstrated a significant fall in COX-2 PGE2 production without any effect on COX-1 TXB2 production in subjects treated with nimesulide (100 mg b.i.d.	nimesulide	197-207	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-111
9427063-10	1997	Nimesulide can thus be considered a relatively selective COX-2 inhibitor.	nimesulide	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-62
9325293-3	1997	There are two cyclooxygenase (Cox) enzymes, Cox-1 and Cox-2, that are responsible for initiating PGE2 synthesis.	Dinoprostone	97-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-59
9441619-0	1997	The Co2+ Adsorption Properties of Al2O3, Fe2O3, Fe3O4, TiO2, and MnO2 Evaluated by Modeling with the Frumkin Isotherm Adsorption of Co(II) ions on metal oxides is related to radioactive 60Co(II) (de)contamination of nuclear power plants, Co(II) ion retention in soils as a plant nutrient, concentration of Co(II) in deep-sea manganese nodules, and other applications.	Manganese	325-334	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-138
9441619-1	1997	Here, the amount of adsorbed Co(II) on metal oxides was measured as a function of the pH and concentration of Co(II) ions, and the adsorption properties of metal oxides were evaluated with a model that considers simultaneous (1:1) and (1:2) exchange reactions between Co2+ aqua ions and surface hydroxyl protons obeying the Frumkin isotherm.	metal oxides	39-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-35
9441619-0	1997	The Co2+ Adsorption Properties of Al2O3, Fe2O3, Fe3O4, TiO2, and MnO2 Evaluated by Modeling with the Frumkin Isotherm Adsorption of Co(II) ions on metal oxides is related to radioactive 60Co(II) (de)contamination of nuclear power plants, Co(II) ion retention in soils as a plant nutrient, concentration of Co(II) in deep-sea manganese nodules, and other applications.	Cobalt(2+)	4-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-138
9441619-0	1997	The Co2+ Adsorption Properties of Al2O3, Fe2O3, Fe3O4, TiO2, and MnO2 Evaluated by Modeling with the Frumkin Isotherm Adsorption of Co(II) ions on metal oxides is related to radioactive 60Co(II) (de)contamination of nuclear power plants, Co(II) ion retention in soils as a plant nutrient, concentration of Co(II) in deep-sea manganese nodules, and other applications.	Cobalt(2+)	4-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	188-194
9441619-0	1997	The Co2+ Adsorption Properties of Al2O3, Fe2O3, Fe3O4, TiO2, and MnO2 Evaluated by Modeling with the Frumkin Isotherm Adsorption of Co(II) ions on metal oxides is related to radioactive 60Co(II) (de)contamination of nuclear power plants, Co(II) ion retention in soils as a plant nutrient, concentration of Co(II) in deep-sea manganese nodules, and other applications.	Cobalt(2+)	4-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	188-194
9441619-0	1997	The Co2+ Adsorption Properties of Al2O3, Fe2O3, Fe3O4, TiO2, and MnO2 Evaluated by Modeling with the Frumkin Isotherm Adsorption of Co(II) ions on metal oxides is related to radioactive 60Co(II) (de)contamination of nuclear power plants, Co(II) ion retention in soils as a plant nutrient, concentration of Co(II) in deep-sea manganese nodules, and other applications.	Aluminum Oxide	34-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-138
9441619-0	1997	The Co2+ Adsorption Properties of Al2O3, Fe2O3, Fe3O4, TiO2, and MnO2 Evaluated by Modeling with the Frumkin Isotherm Adsorption of Co(II) ions on metal oxides is related to radioactive 60Co(II) (de)contamination of nuclear power plants, Co(II) ion retention in soils as a plant nutrient, concentration of Co(II) in deep-sea manganese nodules, and other applications.	Iron(III) oxide	41-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-138
9441619-0	1997	The Co2+ Adsorption Properties of Al2O3, Fe2O3, Fe3O4, TiO2, and MnO2 Evaluated by Modeling with the Frumkin Isotherm Adsorption of Co(II) ions on metal oxides is related to radioactive 60Co(II) (de)contamination of nuclear power plants, Co(II) ion retention in soils as a plant nutrient, concentration of Co(II) in deep-sea manganese nodules, and other applications.	ferryl iron	48-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-138
9441619-0	1997	The Co2+ Adsorption Properties of Al2O3, Fe2O3, Fe3O4, TiO2, and MnO2 Evaluated by Modeling with the Frumkin Isotherm Adsorption of Co(II) ions on metal oxides is related to radioactive 60Co(II) (de)contamination of nuclear power plants, Co(II) ion retention in soils as a plant nutrient, concentration of Co(II) in deep-sea manganese nodules, and other applications.	titanium dioxide	55-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-138
9441619-0	1997	The Co2+ Adsorption Properties of Al2O3, Fe2O3, Fe3O4, TiO2, and MnO2 Evaluated by Modeling with the Frumkin Isotherm Adsorption of Co(II) ions on metal oxides is related to radioactive 60Co(II) (de)contamination of nuclear power plants, Co(II) ion retention in soils as a plant nutrient, concentration of Co(II) in deep-sea manganese nodules, and other applications.	manganese dioxide	65-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-138
9441619-0	1997	The Co2+ Adsorption Properties of Al2O3, Fe2O3, Fe3O4, TiO2, and MnO2 Evaluated by Modeling with the Frumkin Isotherm Adsorption of Co(II) ions on metal oxides is related to radioactive 60Co(II) (de)contamination of nuclear power plants, Co(II) ion retention in soils as a plant nutrient, concentration of Co(II) in deep-sea manganese nodules, and other applications.	metal oxides	147-159	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-138
9441619-0	1997	The Co2+ Adsorption Properties of Al2O3, Fe2O3, Fe3O4, TiO2, and MnO2 Evaluated by Modeling with the Frumkin Isotherm Adsorption of Co(II) ions on metal oxides is related to radioactive 60Co(II) (de)contamination of nuclear power plants, Co(II) ion retention in soils as a plant nutrient, concentration of Co(II) in deep-sea manganese nodules, and other applications.	60co(ii)	186-194	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-138
15810359-3	1997	It was found that the Co(II) of CoCl2 makes an exchanging interaction with Zn(II) in Cu2Zn2SOD and thus the partial Cu2Co2SOD is formed.	cobaltous chloride	32-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-28
11670166-1	1997	3,5-Di-tert-butyl-1,2-semiquinonate (3,5-DBSQ) complexes of Co(II), Cu(II), and Zn(II) have been prepared that contain the hydrotris(cumenylmethyl-pyrazolyl)borate (Tp(Cum,Me)) coligand.	3,5-di-tert-butyl-1,2-semiquinonate	0-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-66
11670166-1	1997	3,5-Di-tert-butyl-1,2-semiquinonate (3,5-DBSQ) complexes of Co(II), Cu(II), and Zn(II) have been prepared that contain the hydrotris(cumenylmethyl-pyrazolyl)borate (Tp(Cum,Me)) coligand.	3,5-dbsq	37-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-66
11670166-1	1997	3,5-Di-tert-butyl-1,2-semiquinonate (3,5-DBSQ) complexes of Co(II), Cu(II), and Zn(II) have been prepared that contain the hydrotris(cumenylmethyl-pyrazolyl)borate (Tp(Cum,Me)) coligand.	hydrotris(cumenylmethyl-pyrazolyl)borate	123-163	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-66
11670166-5	1997	Intersecting cumenyl substituents of the pyrazolylborate ligand encapsulate the Co(II) ion.	pyrazolylborate	41-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-86
11670166-11	1997	The charge distribution in Tp(Cum,Me)Co(3,5-DBSQ) is Co(II)-SQ, rather than the more common Co(III)-Cat, due to surprisingly weak donation by the Tp(Cum,Me) nitrogens.	co(3,5-dbsq)	37-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-59
11670166-11	1997	The charge distribution in Tp(Cum,Me)Co(3,5-DBSQ) is Co(II)-SQ, rather than the more common Co(III)-Cat, due to surprisingly weak donation by the Tp(Cum,Me) nitrogens.	Nitrogen	157-166	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-59
15810359-3	1997	It was found that the Co(II) of CoCl2 makes an exchanging interaction with Zn(II) in Cu2Zn2SOD and thus the partial Cu2Co2SOD is formed.	Zinc	75-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-28
9475035-14	1997	Older nonsteroidal antiinflammatory drugs like aspirin and indomethacin are non selective inhibitors of COX activity and therefore, in addition to inhibiting COX-2 activity, inhibit the formation of eicosanoids by COX-1.	Aspirin	47-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	158-163
9475035-14	1997	Older nonsteroidal antiinflammatory drugs like aspirin and indomethacin are non selective inhibitors of COX activity and therefore, in addition to inhibiting COX-2 activity, inhibit the formation of eicosanoids by COX-1.	Indomethacin	59-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	158-163
9475035-14	1997	Older nonsteroidal antiinflammatory drugs like aspirin and indomethacin are non selective inhibitors of COX activity and therefore, in addition to inhibiting COX-2 activity, inhibit the formation of eicosanoids by COX-1.	Eicosanoids	199-210	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	158-163
9367578-0	1997	Sorption of Metal Ions on Alumina Precipitation and adsorption of metal ions (Co(II), Ni(II), Cu(II), and Cr(III)) on gamma-alumina were investigated experimentally.	Aluminum Oxide	118-131	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-84
9475035-17	1997	Recently drugs such as nimesulide and meloxicam with selective action on COX-2 have been discovered and introduced into medicine.	nimesulide	23-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-78
9475035-17	1997	Recently drugs such as nimesulide and meloxicam with selective action on COX-2 have been discovered and introduced into medicine.	Meloxicam	38-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-78
9367578-2	1997	In the case of Co(II) the pH dependence of rest concentrations with and without alumina is equal; adsorption may be disregarded.	Aluminum Oxide	80-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-21
9330943-5	1997	The TNF-R55 was found to be the major receptor species responsible for ligand binding activity, such as COX-2 induction and PGE2 synthesis, since a specific antireceptor TNF-R55 blocking antibody inhibited about 76% of TNF-alpha binding and TNF-alpha stimulated COX-2 induction and PGE2 production.	Dinoprostone	282-286	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
9327757-6	1997	COX-2 metabolites, measured by radioimmunoassay, were released by both the internal mammary artery and saphenous vein in the following rank order: prostaglandin E2 > or = prostacyclin thromboxane A2.	prostaglandin e2 &gt	147-167	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
9440135-6	1997	Treatment of WISH cells with TNF-alpha (0.1 ng/mL-100 ng/mL) caused a dose-dependent increase in COX-2 expression and the subsequent biosynthesis of PGE2 that persisted for at least 48 hrs.	Dinoprostone	149-153	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
9440135-8	1997	TNF-alpha-stimulated COX-2 expression and the subsequent formation of PGE2 were inhibited by dexamethasone (0.1 microM).	Dinoprostone	70-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-26
9440135-8	1997	TNF-alpha-stimulated COX-2 expression and the subsequent formation of PGE2 were inhibited by dexamethasone (0.1 microM).	Dexamethasone	93-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-26
9440135-9	1997	In addition, indomethacin (1 microM) and the novel COX-2-selective inhibitor, NS-398 (IC50 approximately 1.1 x 10(-9) M), attenuated TNF-alpha-elicited PGE2 production.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	78-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-56
9440135-9	1997	In addition, indomethacin (1 microM) and the novel COX-2-selective inhibitor, NS-398 (IC50 approximately 1.1 x 10(-9) M), attenuated TNF-alpha-elicited PGE2 production.	Dinoprostone	152-156	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-56
9291137-8	1997	In addition, endogenous PGE2 down-regulated the expression of Cox-2 by the two inducers, as stimulation of the cells in the presence of different Cox inhibitors increased the expression of the protein.	Dinoprostone	24-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
9291137-9	1997	Overall, these results suggest that exogenous and endogenous PGE2 exert negative inhibitory effects on Cox-2 expression mediated by stimulation of protein kinase A.	Dinoprostone	61-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-108
9640560-4	1997	(S)-Flurbiprofen, a nonselective COX inhibitor, and SC-558, a COX-2-selective ligand, were docked at the cyclooxygenase binding site in both isozymes, evidencing the role of different residues in the ligand-protein interaction.	SC 558	52-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
9291137-1	1997	U46619, a thromboxane A2 analogue, and basic fibroblast growth factor (FGF-2) both induced the expression of the inducible cyclo-oxygenase (Cox)-2 in porcine aortic smooth-muscle cells.	Thromboxane A2	10-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-146
9291137-3	1997	PD98059, an inhibitor of the ERK pathway, inhibited the expression of Cox-2.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-75
9291137-5	1997	Cox-2 expression induced by U46619 or FGF-2 was similarly reduced by prostaglandin (PGE2), forskolin or dibutyryl-cAMP, suggesting a regulatory effect of adenylate cyclase on Cox-2 expression.	Prostaglandins	69-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
9291137-5	1997	Cox-2 expression induced by U46619 or FGF-2 was similarly reduced by prostaglandin (PGE2), forskolin or dibutyryl-cAMP, suggesting a regulatory effect of adenylate cyclase on Cox-2 expression.	Dinoprostone	84-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
9291137-5	1997	Cox-2 expression induced by U46619 or FGF-2 was similarly reduced by prostaglandin (PGE2), forskolin or dibutyryl-cAMP, suggesting a regulatory effect of adenylate cyclase on Cox-2 expression.	Colforsin	91-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
9291137-5	1997	Cox-2 expression induced by U46619 or FGF-2 was similarly reduced by prostaglandin (PGE2), forskolin or dibutyryl-cAMP, suggesting a regulatory effect of adenylate cyclase on Cox-2 expression.	Bucladesine	104-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
9327757-6	1997	COX-2 metabolites, measured by radioimmunoassay, were released by both the internal mammary artery and saphenous vein in the following rank order: prostaglandin E2 > or = prostacyclin thromboxane A2.	prostacyclin thromboxane a2	174-201	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
9291137-6	1997	However, activation of ERK2 by FGF-2 was not affected by PGE2 whereas that of JNK1 by U46619 was inhibited, suggesting that inhibition of COX-2 expression by cAMP may be downstream of ERK2.	Cyclic AMP	158-162	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	138-143
9291137-7	1997	The effects of PGE2 and forskolin on Cox-2 and phosphorylation of JNK1 were reversed with the protein kinase A inhibitor H89.	Dinoprostone	15-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-42
9327757-8	1997	However, the selective COX-2 inhibitor NS-398 significantly attenuated prostacyclin release from both tissues.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	39-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-28
9291137-7	1997	The effects of PGE2 and forskolin on Cox-2 and phosphorylation of JNK1 were reversed with the protein kinase A inhibitor H89.	Colforsin	24-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-42
9327757-8	1997	However, the selective COX-2 inhibitor NS-398 significantly attenuated prostacyclin release from both tissues.	Epoprostenol	71-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-28
9291137-7	1997	The effects of PGE2 and forskolin on Cox-2 and phosphorylation of JNK1 were reversed with the protein kinase A inhibitor H89.	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	121-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-42
9275047-6	1997	Interleukin-1beta (IL-1beta) elevated Cox-2 mRNA steady state levels in a concentration-dependent manner, and kinetic studies showed that Cox-2 mRNA levels were already induced at the 2 h point and returned to the basal level after incubation for 24 h. The protein synthesis inhibitor, cycloheximide, induced Cox-2 mRNA expression and potentiated the effect of IL-1beta.	Cycloheximide	286-299	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	138-143
9328176-1	1997	The toxicity of Ni(II), Co(II) and Cu(II) in animals, and that of Cd(II) in cultured cells, has been associated with generation of the promutagenic lesion 8-oxo-7,8-dihydroguanine (8-oxoguanine) in DNA, among other effects.	8-hydroxyguanine	155-179	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-30
9328176-1	1997	The toxicity of Ni(II), Co(II) and Cu(II) in animals, and that of Cd(II) in cultured cells, has been associated with generation of the promutagenic lesion 8-oxo-7,8-dihydroguanine (8-oxoguanine) in DNA, among other effects.	8-hydroxyguanine	181-193	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-30
9328176-9	1997	Interestingly, in the absence of Mg(II), the activity of the enzymes could be restored by Co(II) to 73% of that with Mg(II) alone for MutT, and 34% for MTH1, the other metals being much less or non-effective.	mg(ii)	117-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-96
9275047-6	1997	Interleukin-1beta (IL-1beta) elevated Cox-2 mRNA steady state levels in a concentration-dependent manner, and kinetic studies showed that Cox-2 mRNA levels were already induced at the 2 h point and returned to the basal level after incubation for 24 h. The protein synthesis inhibitor, cycloheximide, induced Cox-2 mRNA expression and potentiated the effect of IL-1beta.	Cycloheximide	286-299	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	138-143
9275047-9	1997	Further, IL-1beta-induced synthesis of prostanoids was blocked by a Cox-2-specific inhibitor, NS-398.	Prostaglandins	39-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-73
9275047-9	1997	Further, IL-1beta-induced synthesis of prostanoids was blocked by a Cox-2-specific inhibitor, NS-398.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	94-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-73
9259587-6	1997	Inhibition of either MAPK kinase signaling or of COX-2 in these cells releases them from the influence of the growth-inhibitory PGs and results in the subsequent cell cycle traverse and proliferation.	Phosphatidylglycerols	128-131	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-54
9284101-8	1997	The enhanced production of PGE2 in fibroblasts upon culturing with keratinocytes was due to the induction of COX-2 mRNA mediated by proIL-1alpha released from keratinocytes.	Dinoprostone	27-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-114
9284101-9	1997	These results suggest that cell-cell interactions of keratinocytes and fibroblasts augment the production of PGE2 by a mechanism in which the activity of COX-2 in fibroblasts is increased by the keratinocyte-derived proIL-1alpha in a paracrine manner.	Dinoprostone	109-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	154-159
9276732-6	1997	This alteration in eicosanoid metabolism was associated with induction of cyclooxygenase (Cox)-2 and thromboxane synthase, but not Cox-1.	Eicosanoids	19-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-96
9276732-7	1997	Unlike results seen in other systems, the upregulation of Cox-2 and the subsequent release of eicosanoids by endothelial cells was not directly induced by complement but rather required production of IL-1alpha, which acted on endothelial cells as an autocrine factor.	Eicosanoids	94-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
9261124-2	1997	Here the ability of recombinant human cyclooxygenase-1 (hCOX-1) and cyclooxygenase-2 (hCOX-2) to metabolize anandamide was studied.	anandamide	108-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-92
9261124-3	1997	Baculovirus-expressed and -purified hCOX-2, but not hCOX-1, effectively oxygenated anandamide.	anandamide	83-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-42
9261124-6	1997	Incubation of anandamide with lysates and the intact cell line expressing COX-2 but not that of COX-1 produced prostaglandin E2 ethanolamide.	anandamide	14-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
9261124-6	1997	Incubation of anandamide with lysates and the intact cell line expressing COX-2 but not that of COX-1 produced prostaglandin E2 ethanolamide.	prostaglandin E2 ethanolamide	111-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
9261124-7	1997	These results demonstrate the existence of a COX-2-mediated pathway for anandamide metabolism, and the metabolites formed represent a novel class of prostaglandins.	anandamide	72-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-50
9261124-7	1997	These results demonstrate the existence of a COX-2-mediated pathway for anandamide metabolism, and the metabolites formed represent a novel class of prostaglandins.	Prostaglandins	149-163	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-50
9219792-3	1997	Whereas COX-1 is a constitutive enzyme present at all times and is thought to produce the cytoprotective prostaglandins, COX-2 represents the inducible form of cyclooxygenase leading to production of proinflammatory prostaglandins.	Prostaglandins	216-230	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-126
9266823-1	1997	The cyclooxygenase (COX) isoforms COX-1 and COX-2 convert arachidonic acid to prostaglandin (PG) precursors and are a limiting step in PG production.	Arachidonic Acid	58-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-49
9266823-1	1997	The cyclooxygenase (COX) isoforms COX-1 and COX-2 convert arachidonic acid to prostaglandin (PG) precursors and are a limiting step in PG production.	Prostaglandins	78-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-49
9266823-1	1997	The cyclooxygenase (COX) isoforms COX-1 and COX-2 convert arachidonic acid to prostaglandin (PG) precursors and are a limiting step in PG production.	Prostaglandins	93-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-49
9266823-1	1997	The cyclooxygenase (COX) isoforms COX-1 and COX-2 convert arachidonic acid to prostaglandin (PG) precursors and are a limiting step in PG production.	Prostaglandins	135-137	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-49
9266823-2	1997	Interleukin-1beta (IL-1beta) treatment of type II A549 cells increases PGE2 synthesis via transcription- and translation-dependent induction of COX-2.	Dinoprostone	71-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	144-149
9266823-4	1997	The protein-tyrosine phosphatase inhibitor phenylarsine oxide (PAO) prevented both NF-kappaB activation and induction of COX-2 mRNA.	oxophenylarsine	43-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-126
9266823-4	1997	The protein-tyrosine phosphatase inhibitor phenylarsine oxide (PAO) prevented both NF-kappaB activation and induction of COX-2 mRNA.	oxophenylarsine	63-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-126
9266823-7	1997	We conclude that IL-1beta stimulates PG production via transcriptional activation of COX-2 and provide evidence that this may involve NF-kappaB.	Prostaglandins	37-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-90
9283716-3	1997	Both cyclo-oxygenase isoforms (COX-1 and COX-2) may also form free 8-epi-PGF2 alpha as a minor product.	8-epi-prostaglandin F2alpha	67-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-46
9337697-6	1997	However, substantial amounts of COX-2 were found in the tumours but not in the mucosa, which may explain why many gastric tumours form increased amounts of PGs.	Prostaglandins	156-159	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-37
11669965-4	1997	On the other hand, Co(II)(TPP) and Cr(TPP)(Cl) did not react with hydroxylamine under anaerobic conditions.	tetraphenylporphine sulfonate	26-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-25
11669965-5	1997	With trace amounts of oxygen, the reaction of Co(II)(TPP) with hydroxylamine led to the formation of a stable cobalt(III)-bis(hydroxylamine) complex.	Oxygen	22-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-52
9257931-4	1997	Cyclo-oxygenase (COX) is the rate limiting enzyme in the production of prostanoids and since inflammatory pathways enhance the expression of an inducible COX (COX-2), both COX-2 and iNOS may be co-expressed in response to an inflammatory stimulus.	Prostaglandins	71-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	172-177
9257931-8	1997	Activity of the COX-2 pathway was assessed by PGE2 EIA, and iNOS pathway activity by nitrite assay.	Dinoprostone	46-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-21
9257931-10	1997	IL-1beta alone (1-50 u ml(-1) induced PGE2 formation without significant nitrite formation, a response which was inhibited by the COX-2 specific inhibitor nimesulide.	Dinoprostone	38-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	130-135
9257931-10	1997	IL-1beta alone (1-50 u ml(-1) induced PGE2 formation without significant nitrite formation, a response which was inhibited by the COX-2 specific inhibitor nimesulide.	nimesulide	155-165	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	130-135
11669965-5	1997	With trace amounts of oxygen, the reaction of Co(II)(TPP) with hydroxylamine led to the formation of a stable cobalt(III)-bis(hydroxylamine) complex.	tetraphenylporphine sulfonate	53-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-52
11669965-5	1997	With trace amounts of oxygen, the reaction of Co(II)(TPP) with hydroxylamine led to the formation of a stable cobalt(III)-bis(hydroxylamine) complex.	Hydroxylamine	63-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-52
11669965-8	1997	The one-electron reduction of Co(III)(TPP)(NH(2)OH)(2)(+) formed Co(II)(TPP), for which there was no evidence for the coordination of hydroxylamine.	tetraphenylporphine sulfonate	38-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-71
11669965-8	1997	The one-electron reduction of Co(III)(TPP)(NH(2)OH)(2)(+) formed Co(II)(TPP), for which there was no evidence for the coordination of hydroxylamine.	tetraphenylporphine sulfonate	72-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-71
9249645-6	1997	At the doses employed, celecoxib inhibited only COX-2 and not COX-1.	Celecoxib	23-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-53
9249645-7	1997	Specific COX-2 inhibition with celecoxib causes significant improvement in the signs and symptoms of RA.	Celecoxib	31-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	9-14
9249646-7	1997	In animal models of inflammatory arthritis, COX-2 increases in parallel with PG production and clinical inflammation.	Prostaglandins	77-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-49
9249646-12	1997	Upregulated COX-2 expression undoubtedly plays a role in pathologic processes characterized by increased local PG production.	Prostaglandins	111-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-17
9279772-3	1997	While COX-1 is thought to account for homeostatic amounts of eicosanoids, COX-2 is induced during inflammation leading to pathologic amounts of eicosanoids.	Eicosanoids	144-155	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
9256170-1	1997	We investigated the effects of tranilast on inducible cyclooxygenase (COX2)-mediated prostaglandin E2 (PGE2) production and enzyme induction in interleukin-lbeta (IL-1beta)-stimulated cultured dermal fibroblasts.	Dinoprostone	85-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-74
9256170-1	1997	We investigated the effects of tranilast on inducible cyclooxygenase (COX2)-mediated prostaglandin E2 (PGE2) production and enzyme induction in interleukin-lbeta (IL-1beta)-stimulated cultured dermal fibroblasts.	Dinoprostone	103-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-74
9256170-6	1997	Thus, it is possible for tranilast to regulate PGE2 production by inhibiting COX2 induction.	Dinoprostone	47-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-81
9179403-14	1997	Pretreatment with the conventional non-steroidal anti-inflammatory drugs (NSAIDs), indomethacin and ibuprofen, and the selective COX-2 inhibitors, NS-398 and nimesulide, completely blocked IL-1 beta-induced PGE2 release and COX activity.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	147-153	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-134
9179403-14	1997	Pretreatment with the conventional non-steroidal anti-inflammatory drugs (NSAIDs), indomethacin and ibuprofen, and the selective COX-2 inhibitors, NS-398 and nimesulide, completely blocked IL-1 beta-induced PGE2 release and COX activity.	nimesulide	158-168	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-134
9179403-14	1997	Pretreatment with the conventional non-steroidal anti-inflammatory drugs (NSAIDs), indomethacin and ibuprofen, and the selective COX-2 inhibitors, NS-398 and nimesulide, completely blocked IL-1 beta-induced PGE2 release and COX activity.	Dinoprostone	207-211	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-134
9179403-15	1997	The glucocorticosteroid dexamethasone and protein synthesis inhibitors, cycloheximide and actinomycin D, not only markedly inhibited IL-1 beta-stimulated PGE2 release and COX activity but also suppressed IL-1 beta-induced COX-2 induction.	glucocorticosteroid	4-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	222-227
9179403-15	1997	The glucocorticosteroid dexamethasone and protein synthesis inhibitors, cycloheximide and actinomycin D, not only markedly inhibited IL-1 beta-stimulated PGE2 release and COX activity but also suppressed IL-1 beta-induced COX-2 induction.	Dexamethasone	24-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	222-227
9179403-15	1997	The glucocorticosteroid dexamethasone and protein synthesis inhibitors, cycloheximide and actinomycin D, not only markedly inhibited IL-1 beta-stimulated PGE2 release and COX activity but also suppressed IL-1 beta-induced COX-2 induction.	Cycloheximide	72-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	222-227
9179403-15	1997	The glucocorticosteroid dexamethasone and protein synthesis inhibitors, cycloheximide and actinomycin D, not only markedly inhibited IL-1 beta-stimulated PGE2 release and COX activity but also suppressed IL-1 beta-induced COX-2 induction.	Dactinomycin	90-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	222-227
9138096-10	1997	Dexamethasone, an inhibitor of cyclooxygenase (COX-2) expression and PGE2 synthesis, down-regulated control, constitutive levels of IGFBP-4 mRNA and protein, eliminating the previously demonstrated possibility of cross-talk between glucocorticoid receptor (GR) and PGE2-receptor signalling pathways.	Dexamethasone	0-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
9201258-7	1997	Our data demonstrate that the increase in prostanoid synthesis in coculture essentially depends on rapid induction of COX2 mRNA within 2 h.	Prostaglandins	42-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-122
9253772-9	1997	Development of selective COX-2 inhibitors, such as NS-398, opened a new era in which the side effects of gastric and renal lesions by NSAIDs could be ignored.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	51-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-30
9187256-5	1997	Recently, the identification of a cytokine-inducible isoform of COX, COX-2, has led to the suggestion that salicylate produces its anti-inflammatory actions by inhibiting COX-2 induction through actions on nuclear factor kappaB (NF-kappaB).	Salicylates	107-117	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-74
9187256-5	1997	Recently, the identification of a cytokine-inducible isoform of COX, COX-2, has led to the suggestion that salicylate produces its anti-inflammatory actions by inhibiting COX-2 induction through actions on nuclear factor kappaB (NF-kappaB).	Salicylates	107-117	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	171-176
9187256-6	1997	We have used interleukin 1beta-induced COX-2 in human A549 cells to investigate the mechanism of action of salicylate on COX-2 activity.	Salicylates	107-117	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-126
9171873-1	1997	Series of 1,2-diarylimidazoles has been synthesized and found to contain highly potent and selective inhibitors of the human COX-2 enzyme.	1,2-diarylimidazoles	10-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-130
9187256-7	1997	Sodium salicylate inhibited prostaglandin E2 release when added together with interleukin 1beta for 24 hr with an IC50 value of 5 microg/ml, an effect that was independent of NF-kappaB activation or COX-2 transcription or translation.	Sodium Salicylate	0-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	199-204
9187256-8	1997	Sodium salicylate acutely (30 min) also caused a concentration-dependent inhibition of COX-2 activity measured in the presence of 0, 1, or 10 microM exogenous arachidonic acid.	Sodium Salicylate	0-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-92
9187256-8	1997	Sodium salicylate acutely (30 min) also caused a concentration-dependent inhibition of COX-2 activity measured in the presence of 0, 1, or 10 microM exogenous arachidonic acid.	Arachidonic Acid	159-175	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-92
9187256-9	1997	In contrast, when exogenous arachidonic acid was increased to 30 microM, sodium salicylate was a very weak inhibitor of COX-2 activity with an IC50 of >100 microg/ml.	Arachidonic Acid	28-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-125
9187256-9	1997	In contrast, when exogenous arachidonic acid was increased to 30 microM, sodium salicylate was a very weak inhibitor of COX-2 activity with an IC50 of >100 microg/ml.	Sodium Salicylate	73-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-125
9187256-10	1997	Thus, sodium salicylate is an effective inhibitor of COX-2 activity at concentrations far below those required to inhibit NF-kappaB (20 mg/ml) activation and is easily displaced by arachidonic acid.	Sodium Salicylate	6-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-58
9187256-10	1997	Thus, sodium salicylate is an effective inhibitor of COX-2 activity at concentrations far below those required to inhibit NF-kappaB (20 mg/ml) activation and is easily displaced by arachidonic acid.	Arachidonic Acid	181-197	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-58
9219313-7	1997	NSAIDs that are selective towards COX-2, such as meloxicam, may have an improved side-effect profile over current NSAIDs.	Meloxicam	49-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-39
9219314-7	1997	Clinical studies with meloxican, a selective COX-2 inhibitor, support this view.	meloxican	22-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-50
9219316-0	1997	Meloxicam: selective COX-2 inhibition in clinical practice.	Meloxicam	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-26
9219316-3	1997	A relatively selective COX-2 inhibitor, such as meloxicam, may combine antiinflammatory efficacy with improved tolerability.	Meloxicam	48-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-28
9219316-10	1997	In conclusion, relatively selective COX-2 inhibition exemplified by meloxicam may offer effective symptom relief with an improved GI tolerability profile.	Meloxicam	68-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-41
9219317-4	1997	Of the drugs investigated in the human whole blood assay, only meloxicam showed selectivity for COX-2 at therapeutically relevant concentrations.	Meloxicam	63-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-101
11669815-0	1997	Complexes of the Trioxodinitrate Anion: Synthesis and Characterization of [Zn(II)(bipy)(H(2)O)(N(2)O(3))] and [Co(II)(bipy)(2)(N(2)O(3))].	trioxodinitrate anion	17-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	111-116
9146894-33	1997	These results provide further evidence that prostanoids derived from COX-1 activity are not important in acute inflammatory responses and that a high therapeutic index of anti-inflammatory effect to gastropathy can be achieved with a selective COX-2 inhibitor.	Prostaglandins	44-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	244-249
9146894-0	1997	Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor.	tetrasubstituted furanone	45-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-98
9154324-2	1997	Cyclo-oxygenase (COX), the enzyme responsible for the conversion of arachidonic acid (AA) to prostaglandin H2 (PGH2), exists in two forms, termed COX-1 and COX-2 which are encoded by different genes.	Arachidonic Acid	68-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	156-161
9146894-2	1997	DFU (5,5-dimethyl-3-(3-fluorophenyl)-4-(4-methylsulphonyl)phenyl-2(5H)-furan one) was identified as a novel orally active and highly selective cyclo-oxygenase-2 (COX-2) inhibitor.	5,5-dimethyl-3-(3-fluorophenyl)-4-(4-methylsulfonyl)phenyl-2(5H)-furanone	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	162-167
9146894-2	1997	DFU (5,5-dimethyl-3-(3-fluorophenyl)-4-(4-methylsulphonyl)phenyl-2(5H)-furan one) was identified as a novel orally active and highly selective cyclo-oxygenase-2 (COX-2) inhibitor.	5,5-dimethyl-3-(3-fluorophenyl)-4-(4-methylsulphonyl)phenyl-2(5h)-furan one	5-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	162-167
9146894-4	1997	In CHO cells stably transfected with human COX isozymes, DFU inhibited the arachidonic acid-dependent production of prostaglandin E2 (PGE2) with at least a 1,000 fold selectivity for COX-2 (IC50 = 41 +/- 14 nM) over COX-1 (IC50 > 50 microM).	Arachidonic Acid	75-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	183-188
9146894-4	1997	In CHO cells stably transfected with human COX isozymes, DFU inhibited the arachidonic acid-dependent production of prostaglandin E2 (PGE2) with at least a 1,000 fold selectivity for COX-2 (IC50 = 41 +/- 14 nM) over COX-1 (IC50 > 50 microM).	Dinoprostone	134-138	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	183-188
9154324-2	1997	Cyclo-oxygenase (COX), the enzyme responsible for the conversion of arachidonic acid (AA) to prostaglandin H2 (PGH2), exists in two forms, termed COX-1 and COX-2 which are encoded by different genes.	Prostaglandin H2	93-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	156-161
9146894-5	1997	Indomethacin was a potent inhibitor of both COX-1 (IC50 = 18 +/- 3 nM) and COX-2 (IC50 = 26 +/- 6 nM) under the same assay conditions.	Indomethacin	0-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
9146894-17	1997	DFU inhibited lipopolysaccharide (LPS)-induced PGE2 production (COX-2) in a human whole blood assay with a potency (IC50 = 0.28 +/- 0.04 microM) similar to indomethacin (IC50 = 0.68 +/- 0.17 microM).	Dinoprostone	47-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-69
9154324-2	1997	Cyclo-oxygenase (COX), the enzyme responsible for the conversion of arachidonic acid (AA) to prostaglandin H2 (PGH2), exists in two forms, termed COX-1 and COX-2 which are encoded by different genes.	Prostaglandin H2	111-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	156-161
9154324-16	1997	Treatment of the cells with PMA induced a time-dependent increase in the expression of both COX-1 and COX-2 mRNAs.	Tetradecanoylphorbol Acetate	28-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-107
9154324-20	1997	Classical non-steroidal anti-inflammatory drugs (NSAIDs) inhibited both enzymes with varying potencies but only the three compounds previously shown to be selective COX-2 inhibitors (SC-58125, NS-398 and nimesulide) showed higher potency towards the COX of PMA-treated HUV-EC-C. 8.	1-((4-methylsulfonyl)phenyl)-3-trifluoromethyl-5-(4-fluorophenyl)pyrazole	183-191	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	165-170
9154324-20	1997	Classical non-steroidal anti-inflammatory drugs (NSAIDs) inhibited both enzymes with varying potencies but only the three compounds previously shown to be selective COX-2 inhibitors (SC-58125, NS-398 and nimesulide) showed higher potency towards the COX of PMA-treated HUV-EC-C. 8.	nimesulide	204-214	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	165-170
9154324-21	1997	Overall, it appears that the stimulation of the HUV-EC-C line with PMA selectively induces the COX-2 isoenzyme.	Tetradecanoylphorbol Acetate	67-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-100
15989624-1	1997	Since the discovery of a second isozyme of cyclooxygenase, COX-2, the field of prostaglandin and inflammation research has rapidly developed.	Prostaglandins	79-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-64
21639304-1	1997	Reductive coulometric stripping potentiometry, a technique not hitherto described, has been used to establish that the reduction of Ni(II) and Co(II) dimethylglyoximates, adsorbed on a mercury film electrode, is a 10-electron process.	Mercury	185-192	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	143-149
21639304-2	1997	Exhaustive adsorption of Ni(II) or Co(II) complexes, in the 0-4 mug L(-)(1) concentration range, was achieved by vibrationally promoted electrolysis for 3 min of ~25 muL volume samples, hanging under the working electrode in a nitrogen atmosphere.	Nitrogen	227-235	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-41
9175172-4	1997	Tenoxicam had the lowest IC50hCOX-2/IC50hCOX-1 ratio (1.34), followed by aspirin (1.53) and indomethacin (10.82).	tenoxicam	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-35
9151784-14	1997	Expression of COX-2 is again induced by the microparticle arachidonate fraction, which it may then use to synthesize PGI2.	Arachidonic Acid	58-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
9151784-14	1997	Expression of COX-2 is again induced by the microparticle arachidonate fraction, which it may then use to synthesize PGI2.	Epoprostenol	117-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
9151784-15	1997	Both PGE2 and iloprost, a stable PGI2 analog, evoke human umbilical vein endothelial cell COX-2 expression, albeit with kinetics that differ from the response to platelet microparticles.	Dinoprostone	5-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-95
9151784-15	1997	Both PGE2 and iloprost, a stable PGI2 analog, evoke human umbilical vein endothelial cell COX-2 expression, albeit with kinetics that differ from the response to platelet microparticles.	Iloprost	14-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-95
9247974-6	1997	These results suggest that EGF augments the production of PGE2 by increasing not only the activity of cPLA2 but also the production of COX-2 in A431 cells.	Dinoprostone	58-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-140
18966803-5	1997	These data give important support to understand the importance of Mn(II) and Mn(III) synergistic effect on the analytical method of S(IV) determination based on the Co(II) autoxidation.	manganese(III) acetate dihydrate	77-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	165-171
11669790-3	1997	The active species in oxygen uptake is the CoL(2) complex already suggested in the Co(II)-histamine-O(2) system; however, in the case of pseudopeptides, both CoLH(-)(1) and CoL(2)H(-)(1) complexes can take up oxygen.	Oxygen	22-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
11669790-3	1997	The active species in oxygen uptake is the CoL(2) complex already suggested in the Co(II)-histamine-O(2) system; however, in the case of pseudopeptides, both CoLH(-)(1) and CoL(2)H(-)(1) complexes can take up oxygen.	Oxygen	209-215	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
9126611-1	1997	Human cyclooxygenase-2 (hCox-2) is a key enzyme in the biosynthesis of prostaglandins and the target of nonsteroidal anti-inflammatory drugs.	Prostaglandins	71-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-30
11669742-9	1997	Metathesis reactions with carboxylates yield mononuclear complexes [(Tp(Ph))M(O(2)CR)]; M = Zn(II), Co(II); RCO(2)(-) = acetate, benzoate, 4-fluorobenzoate, and 4-nitrobenzoate.	carboxylates	26-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-106
11669742-13	1997	The 2-aminobenzoate (anthranilate) complexes [(Th(Ph))M(anthranilate)], M = Zn(II), Co(II), have been prepared.	ortho-Aminobenzoates	4-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-90
11669742-13	1997	The 2-aminobenzoate (anthranilate) complexes [(Th(Ph))M(anthranilate)], M = Zn(II), Co(II), have been prepared.	anthranilic acid	21-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-90
11669742-13	1997	The 2-aminobenzoate (anthranilate) complexes [(Th(Ph))M(anthranilate)], M = Zn(II), Co(II), have been prepared.	anthranilic acid	21-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-90
9083004-2	1997	This activity, monitored by the formation of Mn(III)-malate or -malonate, is inhibited by Co(II) but not by superoxide dismutase.	mn(iii)-malate	45-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-96
9083004-2	1997	This activity, monitored by the formation of Mn(III)-malate or -malonate, is inhibited by Co(II) but not by superoxide dismutase.	malonic acid	63-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-96
9126611-2	1997	Recombinant hCox-2 overexpressed in a vaccinia virus (VV)-COS-7 system comprises two glycoforms.	carbonyl sulfide	58-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-18
9126611-5	1997	Results of the expression of WT and N580Q hCox-2 in a Drosophila S2 cell system were also consistent with the N-glycosylation at this site, but low levels of activity were obtained.	Nitrogen	36-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-48
9126611-6	1997	High levels of N-glycosylation heterogeneity are observed in hCox-2 expressed using recombinant baculovirus (BV) in Sf9 cells.	Nitrogen	15-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-67
9126611-8	1997	N-linked oligosaccharide profiling of purified VV and BV WT and S582A mutant hCox-2 showed the presence of high mannose structures, (Man)n (GlcNAc)2, n = 9, 8, 7, 6.	n-linked oligosaccharide	0-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-83
9126611-8	1997	N-linked oligosaccharide profiling of purified VV and BV WT and S582A mutant hCox-2 showed the presence of high mannose structures, (Man)n (GlcNAc)2, n = 9, 8, 7, 6.	Mannose	112-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-83
9126611-8	1997	N-linked oligosaccharide profiling of purified VV and BV WT and S582A mutant hCox-2 showed the presence of high mannose structures, (Man)n (GlcNAc)2, n = 9, 8, 7, 6.	Nitrogen	4-5	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-83
9126611-8	1997	N-linked oligosaccharide profiling of purified VV and BV WT and S582A mutant hCox-2 showed the presence of high mannose structures, (Man)n (GlcNAc)2, n = 9, 8, 7, 6.	2-acetamido-2-deoxy-4-O-(beta-2-acetamid-2-deoxyglucopyranosyl)glucopyranose	140-146	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-83
9083488-0	1997	Effect of structural modification of enol-carboxamide-type nonsteroidal antiinflammatory drugs on COX-2/COX-1 selectivity.	enol-carboxamide	37-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-103
9083488-2	1997	In subsequent screening in microsomal assays using human COX-1 and COX-2, we discovered that it possessed a selectivity profile for COX-2 superior to piroxicam and other marketed NSAIDs.	Piroxicam	150-159	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-72
9083488-3	1997	We therefore embarked on a study of enol-carboxamide type compounds to determine if COX-2 selectivity and potency could be dramatically improved by structural modification.	enol-carboxamide	36-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-89
21639224-5	1997	According to the proposed reaction mechanism, dissolved Co(II) is oxidized to Co(III) upon addition of nioxime and high concentrations of ammonia and nitrite; a mixed Co(III)-ammonia-nitrite complex is adsorbed on the electrode surface; the Co(III) is reduced to Co(II) (complexed by nioxime) during the voltammetric scan, followed by its chemical reoxidation by the nitrite, initiating a catalytically enhanced current.	(1Z,2Z)-Cyclohexane-1,2-dione dioxime	103-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-62
21639224-5	1997	According to the proposed reaction mechanism, dissolved Co(II) is oxidized to Co(III) upon addition of nioxime and high concentrations of ammonia and nitrite; a mixed Co(III)-ammonia-nitrite complex is adsorbed on the electrode surface; the Co(III) is reduced to Co(II) (complexed by nioxime) during the voltammetric scan, followed by its chemical reoxidation by the nitrite, initiating a catalytically enhanced current.	Ammonia	138-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-62
21639224-5	1997	According to the proposed reaction mechanism, dissolved Co(II) is oxidized to Co(III) upon addition of nioxime and high concentrations of ammonia and nitrite; a mixed Co(III)-ammonia-nitrite complex is adsorbed on the electrode surface; the Co(III) is reduced to Co(II) (complexed by nioxime) during the voltammetric scan, followed by its chemical reoxidation by the nitrite, initiating a catalytically enhanced current.	Nitrites	150-157	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-62
21639224-5	1997	According to the proposed reaction mechanism, dissolved Co(II) is oxidized to Co(III) upon addition of nioxime and high concentrations of ammonia and nitrite; a mixed Co(III)-ammonia-nitrite complex is adsorbed on the electrode surface; the Co(III) is reduced to Co(II) (complexed by nioxime) during the voltammetric scan, followed by its chemical reoxidation by the nitrite, initiating a catalytically enhanced current.	ammonia nitrite	175-190	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-62
21639224-5	1997	According to the proposed reaction mechanism, dissolved Co(II) is oxidized to Co(III) upon addition of nioxime and high concentrations of ammonia and nitrite; a mixed Co(III)-ammonia-nitrite complex is adsorbed on the electrode surface; the Co(III) is reduced to Co(II) (complexed by nioxime) during the voltammetric scan, followed by its chemical reoxidation by the nitrite, initiating a catalytically enhanced current.	ammonia nitrite	175-190	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	263-269
21639224-5	1997	According to the proposed reaction mechanism, dissolved Co(II) is oxidized to Co(III) upon addition of nioxime and high concentrations of ammonia and nitrite; a mixed Co(III)-ammonia-nitrite complex is adsorbed on the electrode surface; the Co(III) is reduced to Co(II) (complexed by nioxime) during the voltammetric scan, followed by its chemical reoxidation by the nitrite, initiating a catalytically enhanced current.	(1Z,2Z)-Cyclohexane-1,2-dione dioxime	284-291	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-62
21639224-5	1997	According to the proposed reaction mechanism, dissolved Co(II) is oxidized to Co(III) upon addition of nioxime and high concentrations of ammonia and nitrite; a mixed Co(III)-ammonia-nitrite complex is adsorbed on the electrode surface; the Co(III) is reduced to Co(II) (complexed by nioxime) during the voltammetric scan, followed by its chemical reoxidation by the nitrite, initiating a catalytically enhanced current.	Nitrites	183-190	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-62
21639224-5	1997	According to the proposed reaction mechanism, dissolved Co(II) is oxidized to Co(III) upon addition of nioxime and high concentrations of ammonia and nitrite; a mixed Co(III)-ammonia-nitrite complex is adsorbed on the electrode surface; the Co(III) is reduced to Co(II) (complexed by nioxime) during the voltammetric scan, followed by its chemical reoxidation by the nitrite, initiating a catalytically enhanced current.	Nitrites	183-190	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	263-269
9137753-2	1997	The method utilized the phenomenon that the lophine-Co(II)-H2O2 chemiluminescence (CL) reaction is enhanced in alkaline media by the addition of hydroxylammonium chloride.	lophine	44-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-58
9100897-2	1997	LPS seems to increase the PGE2 level in the entire brain via the induction of COX-2.	Dinoprostone	26-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-83
9100898-2	1997	These results imply that circulating IL-1 beta acts on its receptor on the endothelial cells of the brain vasculature to induce COX-2 mRNA, which is possibly responsible for the elevated level of PGE2 seen during fever.	Dinoprostone	196-200	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	128-133
9065752-3	1997	Vanadate also stimulated an increase in COX-2 protein levels, but did not affect significantly the levels of constitutively expressed COX-1 protein.	Vanadates	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
9138698-13	1997	However, a mixture of cytokines (interleukin-1 beta (IL-1 beta), tumour necrosis factor alpha (TNF alpha) and interferon gamma (IFN gamma) each at 10 ng ml-1) induced COX-2 mRNA expression, which was maximal at 12 h and inhibited by dexamethasone (1 microM; added 30 min before the cytokines).	Dexamethasone	233-246	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	167-172
9138698-14	1997	Furthermore, COX-2 protein was detected 24 h after the cytokine treatment and the expression of this protein was also inhibited by dexamethasone (1 microM) and cyclohexamide (10 micrograms ml-1; added 30 min before the cytokines).	Dexamethasone	131-144	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
9138698-14	1997	Furthermore, COX-2 protein was detected 24 h after the cytokine treatment and the expression of this protein was also inhibited by dexamethasone (1 microM) and cyclohexamide (10 micrograms ml-1; added 30 min before the cytokines).	4-[2-(3,5-dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]piperidine-2,6-dione	160-173	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
9138698-19	1997	In experiments where COX-2 metabolized endogenous stores of arachidonic acid, treatment of HASM cells with IL-1 beta in combination with TNF alpha caused a similar release of PGE2 to that when the three cytokines were given in combination.	Arachidonic Acid	60-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-26
9137753-2	1997	The method utilized the phenomenon that the lophine-Co(II)-H2O2 chemiluminescence (CL) reaction is enhanced in alkaline media by the addition of hydroxylammonium chloride.	Hydrogen Peroxide	59-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-58
9138698-24	1997	These findings suggest that the increased expression of COX-2 is intimately involved in the exaggerated release of prostanoids from HASM cells exposed to pro-inflammatory cytokines.	Prostaglandins	115-126	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-61
9137753-2	1997	The method utilized the phenomenon that the lophine-Co(II)-H2O2 chemiluminescence (CL) reaction is enhanced in alkaline media by the addition of hydroxylammonium chloride.	Hydroxylamine	145-170	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-58
15989631-0	1997	Meloxicam: a selective COX-2 inhibitor non-steroidal anti-inflammatory drug.	Meloxicam	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-28
15989631-1	1997	Meloxicam is a new non-steroidal anti-inflammatory drug (NSAID) that selectively inhibits the inducible isoform of the cyclo-oxygenase (COX)-2 enzyme.	Meloxicam	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-142
15989631-4	1997	Only meloxicam and (albeit to a lesser extent) nimesulide could be described as selective for COX-2.	Meloxicam	5-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-99
15989631-4	1997	Only meloxicam and (albeit to a lesser extent) nimesulide could be described as selective for COX-2.	nimesulide	47-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-99
9245316-0	1997	Surface Precipitation of Co(II)(aq) on Al2O3 Surface precipitation is an important process in many areas of science and technology, including modeling contaminant segregation from groundwater to solid phases and dispersion of active phases on catalyst supports.	aq	32-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-31
21533404-1	1997	Expression of the inducible isoform of the cyclooxygenase gene (PGHS-2, COX-2) which codes for the enzyme that catalyzes formation of prostaglandins, was detected in 13/13 human breast tumors of high grade but not in samples of normal breast tissue.	Prostaglandins	134-148	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
9117018-3	1997	IL-1 beta enhanced PGE2 formation in a concentration- and time-dependent manner, reaching its peak at 6 to 8 h and fading at 18 to 24 h. Immunoblot analysis showed that the inducible cyclooxygenase enzyme (COX-2) was expressed only in IL-1 beta treated cells, whereas the constitutive isoform of cyclooxygenase (COX-1) remained unaltered.	Dinoprostone	19-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	206-211
9117018-4	1997	COX-2 expression and PGE2 formation were inhibited by dexamethasone (2 microM), cycloheximide (10 microM), and IL-1-receptor antagonist (IL-1 ra) (250 ng/ml), independently.	Dexamethasone	54-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
9117018-4	1997	COX-2 expression and PGE2 formation were inhibited by dexamethasone (2 microM), cycloheximide (10 microM), and IL-1-receptor antagonist (IL-1 ra) (250 ng/ml), independently.	Cycloheximide	80-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
9117018-5	1997	PGE2 synthesis was significantly reduced by compound SC-58125, a specific COX-2 inhibitor.	Dinoprostone	0-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
9117018-5	1997	PGE2 synthesis was significantly reduced by compound SC-58125, a specific COX-2 inhibitor.	1-((4-methylsulfonyl)phenyl)-3-trifluoromethyl-5-(4-fluorophenyl)pyrazole	53-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
9117018-6	1997	The close parallelism between the kinetics of COX-2 protein expression and PGE2 accumulation, as well as the constitutive nature of COX-1 isoform, indicate that IL-1 beta-driven PGE2 formation in human bronchial smooth-muscle cells is mediated by de novo expression of COX-2 enzyme.	Dinoprostone	178-182	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
9117018-6	1997	The close parallelism between the kinetics of COX-2 protein expression and PGE2 accumulation, as well as the constitutive nature of COX-1 isoform, indicate that IL-1 beta-driven PGE2 formation in human bronchial smooth-muscle cells is mediated by de novo expression of COX-2 enzyme.	Dinoprostone	178-182	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	269-274
9245316-0	1997	Surface Precipitation of Co(II)(aq) on Al2O3 Surface precipitation is an important process in many areas of science and technology, including modeling contaminant segregation from groundwater to solid phases and dispersion of active phases on catalyst supports.	Aluminum Oxide	39-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-31
9245316-1	1997	XAFS, TEM, and XPS measurements of Co(II) sorbed on Al2O3 demonstrate that surface precipitates have formed from solutions that are undersaturated with respect to any known bulk solid phase.	Aluminum Oxide	52-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-41
9245316-3	1997	The data plus thermodynamic reasoning have been used to analyze the plausibility of various models for surface precipitation and to show that for Co(II)/Al2O3 it occurs by forming a double-hydroxide phase containing substrate-derived Al(III) ions.	Aluminum Oxide	153-158	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	146-152
9245316-3	1997	The data plus thermodynamic reasoning have been used to analyze the plausibility of various models for surface precipitation and to show that for Co(II)/Al2O3 it occurs by forming a double-hydroxide phase containing substrate-derived Al(III) ions.	al(iii)	234-241	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	146-152
9245316-4	1997	This idea was corroborated by mixing aqueous solutions of Al(III) and Co(II) at the pH and concentration of the sorption samples, forming a stable colloidal precipitate that is less soluble than either Al(OH)3 or Co(OH)2.	Aluminum Hydroxide	202-209	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-76
9245316-4	1997	This idea was corroborated by mixing aqueous solutions of Al(III) and Co(II) at the pH and concentration of the sorption samples, forming a stable colloidal precipitate that is less soluble than either Al(OH)3 or Co(OH)2.	Carbonic Acid	213-220	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-76
9056314-15	1997	It has been shown that similar mixed-cation hydroxide compounds can be synthesized when Mg(II), Ni(II), Co(II), Zn(II), or Mn(II) is added to suspensions containing Al(III), Fe(III), and Cr(III).	Cations	37-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-110
9032453-3	1997	In many systems, COX-1 is a constitutively expressed isoform that is responsible for normal physiological production of PGs, whereas COX-2 is an inducible isoform that responds to cytokines, endotoxin and growth factors by producing high levels of PGs.	Phosphatidylglycerols	248-251	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	133-138
9032453-8	1997	Preincubation of cells with the novel COX-2 enzymic inhibitor NS-398 (10(-5)-10(-10) M) completely prevented PGE2 formation in a dose-dependent manner.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	62-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-43
9032453-8	1997	Preincubation of cells with the novel COX-2 enzymic inhibitor NS-398 (10(-5)-10(-10) M) completely prevented PGE2 formation in a dose-dependent manner.	Dinoprostone	109-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-43
9032453-10	1997	In addition, Dex (0.1 microM) was only partly effective at preventing EGF-induced COX-2 mRNA and protein expression de novo, whereas Dex completely inhibited TNF-alpha-promoted COX-2 mRNA and protein expression.	Dexamethasone	13-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
9032453-10	1997	In addition, Dex (0.1 microM) was only partly effective at preventing EGF-induced COX-2 mRNA and protein expression de novo, whereas Dex completely inhibited TNF-alpha-promoted COX-2 mRNA and protein expression.	Dexamethasone	133-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	177-182
9056314-15	1997	It has been shown that similar mixed-cation hydroxide compounds can be synthesized when Mg(II), Ni(II), Co(II), Zn(II), or Mn(II) is added to suspensions containing Al(III), Fe(III), and Cr(III).	hydroxide ion	44-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-110
9056314-15	1997	It has been shown that similar mixed-cation hydroxide compounds can be synthesized when Mg(II), Ni(II), Co(II), Zn(II), or Mn(II) is added to suspensions containing Al(III), Fe(III), and Cr(III).	al(iii)	165-172	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-110
9084574-1	1997	BACKGROUND: Meloxicam is a new NSAID with selectivity for the inducible cyclooxygenase (COX-2) in vitro.	Meloxicam	12-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-93
9056314-15	1997	It has been shown that similar mixed-cation hydroxide compounds can be synthesized when Mg(II), Ni(II), Co(II), Zn(II), or Mn(II) is added to suspensions containing Al(III), Fe(III), and Cr(III).	ferric sulfate	174-181	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-110
9056314-15	1997	It has been shown that similar mixed-cation hydroxide compounds can be synthesized when Mg(II), Ni(II), Co(II), Zn(II), or Mn(II) is added to suspensions containing Al(III), Fe(III), and Cr(III).	tris(1,10-phenanthroline)chromium(III) chloride	187-194	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-110
9012840-5	1997	The increase in COX-2 protein is associated with a dose- and time-dependent increase in PG levels in the basolateral, but not apical, medium.	Prostaglandins	88-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-21
9035018-5	1997	New research has revealed that PG are synthesized by 2 forms of the enzyme cyclooxygenase, COX-1 and COX-2.	Prostaglandins	31-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-106
9035018-6	1997	Since COX-1 generally produces PG responsible for cytoprotective functions and COX-2 produces PG in inflammatory reactions, it is a reasonable hypothesis that drugs that are selective inhibitors of COX-2 should be effective antiinflammatory agents with few toxic side effects.	Prostaglandins	94-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-84
9035018-6	1997	Since COX-1 generally produces PG responsible for cytoprotective functions and COX-2 produces PG in inflammatory reactions, it is a reasonable hypothesis that drugs that are selective inhibitors of COX-2 should be effective antiinflammatory agents with few toxic side effects.	Prostaglandins	94-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	198-203
9035019-10	1997	Results show that etodolac has 10-fold selectivity for COX-2 and indicate that etodolac"s pharmacotherapeutic efficacy can be explained by its demonstrably selective inhibition of COX-2, amplified by its favorable tissular pharmacokinetics.	Etodolac	18-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-60
9035019-10	1997	Results show that etodolac has 10-fold selectivity for COX-2 and indicate that etodolac"s pharmacotherapeutic efficacy can be explained by its demonstrably selective inhibition of COX-2, amplified by its favorable tissular pharmacokinetics.	Etodolac	18-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	180-185
9035019-10	1997	Results show that etodolac has 10-fold selectivity for COX-2 and indicate that etodolac"s pharmacotherapeutic efficacy can be explained by its demonstrably selective inhibition of COX-2, amplified by its favorable tissular pharmacokinetics.	Etodolac	79-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	180-185
9154274-5	1997	Inhibition of COX-2 leads to the therapeutically desired inhibition of the synthesis of pro-inflammatory PGs, but at the same time produces side effects associated with inhibition of COX-1 and the consequent suppression of the production of PGs necessary for normal cellular functions.	Prostaglandins	105-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
9154274-5	1997	Inhibition of COX-2 leads to the therapeutically desired inhibition of the synthesis of pro-inflammatory PGs, but at the same time produces side effects associated with inhibition of COX-1 and the consequent suppression of the production of PGs necessary for normal cellular functions.	Prostaglandins	241-244	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
9020770-4	1997	In an effort to understand the origin of the stability of the metal complex, we have employed an anaerobic optical spectroscopic, competitive metal binding assay to determine the coordination geometry and association constants (Ka) for the binding of Co(II) to wild-type gp32 and a series of zinc ligand substitution mutants.	Metals	62-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	251-257
9020770-4	1997	In an effort to understand the origin of the stability of the metal complex, we have employed an anaerobic optical spectroscopic, competitive metal binding assay to determine the coordination geometry and association constants (Ka) for the binding of Co(II) to wild-type gp32 and a series of zinc ligand substitution mutants.	Metals	142-147	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	251-257
9020770-8	1997	Co(II) binding isotherms obtained for three His64 substitution mutants, H64C, H64D, and H64N gp32s, suggest that each mutant forms a dimeric Cys4 tetrathiolate intermediate complex at limiting [Co(II)]f, each then rearranges at high [Co(II)]f to form a monomolecular site of the expected geometry and Ka approximately 1 x 10(4) M-1.	cys4 tetrathiolate	141-159	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
9020770-8	1997	Co(II) binding isotherms obtained for three His64 substitution mutants, H64C, H64D, and H64N gp32s, suggest that each mutant forms a dimeric Cys4 tetrathiolate intermediate complex at limiting [Co(II)]f, each then rearranges at high [Co(II)]f to form a monomolecular site of the expected geometry and Ka approximately 1 x 10(4) M-1.	cys4 tetrathiolate	141-159	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	194-200
9020770-8	1997	Co(II) binding isotherms obtained for three His64 substitution mutants, H64C, H64D, and H64N gp32s, suggest that each mutant forms a dimeric Cys4 tetrathiolate intermediate complex at limiting [Co(II)]f, each then rearranges at high [Co(II)]f to form a monomolecular site of the expected geometry and Ka approximately 1 x 10(4) M-1.	cys4 tetrathiolate	141-159	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	194-200
9012840-8	1997	Two specific COX-2 inhibitors, SC-58125 and NS 398, also, in a dose-dependent manner, attenuate baseline and type alpha transforming growth factor-stimulated mitogenesis, although PG levels are decreased > 90% at all concentrations of inhibitor tested.	1-((4-methylsulfonyl)phenyl)-3-trifluoromethyl-5-(4-fluorophenyl)pyrazole	31-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
9012840-8	1997	Two specific COX-2 inhibitors, SC-58125 and NS 398, also, in a dose-dependent manner, attenuate baseline and type alpha transforming growth factor-stimulated mitogenesis, although PG levels are decreased > 90% at all concentrations of inhibitor tested.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	44-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
9012840-8	1997	Two specific COX-2 inhibitors, SC-58125 and NS 398, also, in a dose-dependent manner, attenuate baseline and type alpha transforming growth factor-stimulated mitogenesis, although PG levels are decreased > 90% at all concentrations of inhibitor tested.	Prostaglandins	180-182	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
8995407-0	1997	Ligand perturbation effects on a pseudotetrahedral Co(II)(His)3-ligand site.	Histidine	58-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-57
9028903-0	1997	XAFS and Bond-Valence Determination of the Structures and Compositions of Surface Functional Groups and Pb(II) and Co(II) Sorption Products on Single-Crystal alpha-Al2O3 The structures and compositions of Pb(II) adsorption complexes and surface binding sites on alpha-Al2O3 (0001) and (1&1macr;02) surfaces were investigated in the presence of water using grazing-incidence X-ray absorption fine structure (GI-XAFS) spectroscopy.	alpha-al2o3	158-169	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-121
9028903-4	1997	The EXAFS and modeling results suggest that Pb(II) and Co(II) ions bond to [AlAlAl-->O-1/2--> and [Al-OH+1/22] surface functional groups.	al-oh	105-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-61
8995407-3	1997	The His-B10 residues in this hexamer form tris imidazole chelates in which pseudotetrahedral Co(II) centers are completed by an exogenous fourth ligand.	Histidine	4-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-99
8995407-3	1997	The His-B10 residues in this hexamer form tris imidazole chelates in which pseudotetrahedral Co(II) centers are completed by an exogenous fourth ligand.	tris imidazole	42-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-99
8995407-5	1997	The spectra obtained for the adducts formed with halides, pseudohalides, trichloroacetate, nitrate, imidazole, and 1-methylimidazole appear to be representative of near tetrahedral Co(II) geometries.	halides	49-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	181-187
8995407-5	1997	The spectra obtained for the adducts formed with halides, pseudohalides, trichloroacetate, nitrate, imidazole, and 1-methylimidazole appear to be representative of near tetrahedral Co(II) geometries.	pseudohalides	58-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	181-187
8995407-5	1997	The spectra obtained for the adducts formed with halides, pseudohalides, trichloroacetate, nitrate, imidazole, and 1-methylimidazole appear to be representative of near tetrahedral Co(II) geometries.	Trichloroacetic Acid	73-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	181-187
8995407-5	1997	The spectra obtained for the adducts formed with halides, pseudohalides, trichloroacetate, nitrate, imidazole, and 1-methylimidazole appear to be representative of near tetrahedral Co(II) geometries.	Nitrates	91-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	181-187
8995407-5	1997	The spectra obtained for the adducts formed with halides, pseudohalides, trichloroacetate, nitrate, imidazole, and 1-methylimidazole appear to be representative of near tetrahedral Co(II) geometries.	imidazole	100-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	181-187
8995407-5	1997	The spectra obtained for the adducts formed with halides, pseudohalides, trichloroacetate, nitrate, imidazole, and 1-methylimidazole appear to be representative of near tetrahedral Co(II) geometries.	1-methylimidazole	115-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	181-187
9003432-3	1997	After short time of incubation, broad signals assigned to low-spin Co(II) of cob(II)alamin and doublet signals assigned to an organic radical intermediate derived from each substrate were observed with 1,2-propanediol, 1,2-ethanediol, glycerol and meso-2,3-butanediol with the magnitude of their exchange interaction (J-value) decreasing in this order.	cob(II)alamin	77-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-73
8995407-7	1997	The MCD spectrum of the phenolate adduct is very similar to those of Co(II)-carbonic anhydrase (alkaline form) and Co(II)-beta-lactamase.	phenoxy radical	24-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-75
8995407-7	1997	The MCD spectrum of the phenolate adduct is very similar to those of Co(II)-carbonic anhydrase (alkaline form) and Co(II)-beta-lactamase.	phenoxy radical	24-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-121
9003432-3	1997	After short time of incubation, broad signals assigned to low-spin Co(II) of cob(II)alamin and doublet signals assigned to an organic radical intermediate derived from each substrate were observed with 1,2-propanediol, 1,2-ethanediol, glycerol and meso-2,3-butanediol with the magnitude of their exchange interaction (J-value) decreasing in this order.	Propylene Glycol	202-217	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-73
8995407-9	1997	The close similarity of the Co(II)-R6-pentafluorophenolate and Co(II)-R6-phenolate spectra demonstrates that the Co(II)-carbonic anhydrase-like spectral profile is preserved despite a substantial perturbation in the electron withdrawing nature of the coordinated phenolate oxygen atom.	phenoxy radical	49-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-34
9003432-3	1997	After short time of incubation, broad signals assigned to low-spin Co(II) of cob(II)alamin and doublet signals assigned to an organic radical intermediate derived from each substrate were observed with 1,2-propanediol, 1,2-ethanediol, glycerol and meso-2,3-butanediol with the magnitude of their exchange interaction (J-value) decreasing in this order.	Ethylene Glycol	219-233	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-73
8995407-9	1997	The close similarity of the Co(II)-R6-pentafluorophenolate and Co(II)-R6-phenolate spectra demonstrates that the Co(II)-carbonic anhydrase-like spectral profile is preserved despite a substantial perturbation in the electron withdrawing nature of the coordinated phenolate oxygen atom.	Oxygen	273-279	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-34
8995407-9	1997	The close similarity of the Co(II)-R6-pentafluorophenolate and Co(II)-R6-phenolate spectra demonstrates that the Co(II)-carbonic anhydrase-like spectral profile is preserved despite a substantial perturbation in the electron withdrawing nature of the coordinated phenolate oxygen atom.	Oxygen	273-279	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-69
8995407-9	1997	The close similarity of the Co(II)-R6-pentafluorophenolate and Co(II)-R6-phenolate spectra demonstrates that the Co(II)-carbonic anhydrase-like spectral profile is preserved despite a substantial perturbation in the electron withdrawing nature of the coordinated phenolate oxygen atom.	Oxygen	273-279	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-69
8995407-10	1997	We conclude that this type of spectrum must arise from a specific Co(II) coordination geometry common to each of the Co(II) sites in the Co(II)-R6-phenolate, Co(II)-R6-pentafluorophenolate, Co(II)-beta-lactamase, and the alkaline Co(II)-carbonic anhydrase species.	r6-phenolate	144-156	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-72
8995407-10	1997	We conclude that this type of spectrum must arise from a specific Co(II) coordination geometry common to each of the Co(II) sites in the Co(II)-R6-phenolate, Co(II)-R6-pentafluorophenolate, Co(II)-beta-lactamase, and the alkaline Co(II)-carbonic anhydrase species.	r6-phenolate	144-156	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-123
8995407-10	1997	We conclude that this type of spectrum must arise from a specific Co(II) coordination geometry common to each of the Co(II) sites in the Co(II)-R6-phenolate, Co(II)-R6-pentafluorophenolate, Co(II)-beta-lactamase, and the alkaline Co(II)-carbonic anhydrase species.	r6-phenolate	144-156	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-123
8995407-10	1997	We conclude that this type of spectrum must arise from a specific Co(II) coordination geometry common to each of the Co(II) sites in the Co(II)-R6-phenolate, Co(II)-R6-pentafluorophenolate, Co(II)-beta-lactamase, and the alkaline Co(II)-carbonic anhydrase species.	r6-phenolate	144-156	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-123
8995407-10	1997	We conclude that this type of spectrum must arise from a specific Co(II) coordination geometry common to each of the Co(II) sites in the Co(II)-R6-phenolate, Co(II)-R6-pentafluorophenolate, Co(II)-beta-lactamase, and the alkaline Co(II)-carbonic anhydrase species.	r6-phenolate	144-156	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-123
8995407-10	1997	We conclude that this type of spectrum must arise from a specific Co(II) coordination geometry common to each of the Co(II) sites in the Co(II)-R6-phenolate, Co(II)-R6-pentafluorophenolate, Co(II)-beta-lactamase, and the alkaline Co(II)-carbonic anhydrase species.	r6-phenolate	144-156	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-123
8995407-11	1997	These spectroscopic results are consistent with a trigonally distorted tetrahedral Co(II) geometry (C3v), an interpretation supported by the pseudotetrahedral Zn(II)(His)3(phenolate) center identified in a Zn(II)-R6 crystal structure (Smith, G. D., and Dodson, G. G. (1992) Biopolymers 32, 441-445).	Zinc	159-165	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-89
9177101-7	1997	Due to the activation of the gene for COX-2, the actual synthesis of PGI2 as well as the conversion rate to 6-oxo-PGF1 alpha are increased in activated smooth muscle cells, an effect being abolished by the PG"s administered.	Epoprostenol	69-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-43
9321934-0	1997	From indomethacin to a selective COX-2 inhibitor.	Indomethacin	5-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-38
9547553-5	1997	Potent anti-inflammatory agents like the glucocorticoids are known to inhibit specifically the expression of COX-2 while commercially available NSAIDs like indomethacin inhibit both COX-1 and COX-2.	Indomethacin	156-168	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	192-197
9177100-5	1997	It is possible that enhanced endogenous prostacyclin biosynthesis, subsequent to induction of COX-2 and/or in relation to the formation of a neointima from media smooth muscle cells, might have a similar effect.	Epoprostenol	40-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-99
9177101-7	1997	Due to the activation of the gene for COX-2, the actual synthesis of PGI2 as well as the conversion rate to 6-oxo-PGF1 alpha are increased in activated smooth muscle cells, an effect being abolished by the PG"s administered.	androst-4-ene-3,6,17-trione	108-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-43
9177101-7	1997	Due to the activation of the gene for COX-2, the actual synthesis of PGI2 as well as the conversion rate to 6-oxo-PGF1 alpha are increased in activated smooth muscle cells, an effect being abolished by the PG"s administered.	prostaglandin F1	114-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-43
15989563-3	1997	Meloxicam, with some selectivity for COX-2, is already marketed, and at least two companies are carrying out clinical studies with selective inhibitors.	Meloxicam	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-42
9597082-3	1997	Recent data indicate that eicosanoids, primarily the products of the inducible form of cyclooxygenase (COX-2), are involved in the regulation of cytokine production.	Eicosanoids	26-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-108
9099957-6	1997	DmPGE2 also increased the steady-state mRNA levels of its own inducible synthesizing enzyme, COX-2, as well as cellular growth to levels similar to those seen with fetal calf serum and phorbol ester.	16,16-Dimethylprostaglandin E2	0-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-98
9099957-8	1997	In PC-3 cells, the dmPGE2 regulation of the COX-2 mRNA levels was both time dependent, with maximum stimulation seen 2 h after addition, and dose dependent on dmPGE2 concentration, with maximum stimulation seen at 5 microg ml(-1).	16,16-Dimethylprostaglandin E2	19-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-49
9099957-8	1997	In PC-3 cells, the dmPGE2 regulation of the COX-2 mRNA levels was both time dependent, with maximum stimulation seen 2 h after addition, and dose dependent on dmPGE2 concentration, with maximum stimulation seen at 5 microg ml(-1).	16,16-Dimethylprostaglandin E2	159-165	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-49
9099957-9	1997	The non-steroidal anti-inflammatory drug flurbiprofen (5 microM), in the presence of exogenous dmPGE2, inhibited the up-regulation of COX-2 mRNA and PC-3 cell growth.	Flurbiprofen	41-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-139
9099957-9	1997	The non-steroidal anti-inflammatory drug flurbiprofen (5 microM), in the presence of exogenous dmPGE2, inhibited the up-regulation of COX-2 mRNA and PC-3 cell growth.	16,16-Dimethylprostaglandin E2	95-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-139
9099957-10	1997	Taken together, these data suggest that PGE2 has a specific role in the maintenance of human cancer cell growth and that the activation of COX-2 expression depends primarily upon newly synthesized PGE2, perhaps resulting from changes in local cellular PGE2 concentrations.	Dinoprostone	197-201	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-144
9099957-10	1997	Taken together, these data suggest that PGE2 has a specific role in the maintenance of human cancer cell growth and that the activation of COX-2 expression depends primarily upon newly synthesized PGE2, perhaps resulting from changes in local cellular PGE2 concentrations.	Dinoprostone	197-201	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-144
9011588-3	1997	Slot-blot analysis of cyclooxygenase-1 (Cox-1) and Cox-2 demonstrated a decrease in both Cox-1 (29%) and, to a greater extent, Cox-2 (65%) protein expression after BFS stimulation.	benzo(b)fluoranthene	164-167	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-56
9011588-3	1997	Slot-blot analysis of cyclooxygenase-1 (Cox-1) and Cox-2 demonstrated a decrease in both Cox-1 (29%) and, to a greater extent, Cox-2 (65%) protein expression after BFS stimulation.	benzo(b)fluoranthene	164-167	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	127-132
9011588-5	1997	After exposure of samples to BFS for 30 minutes, the level of Cox-2 mRNA was reduced to 0.59+/-0.449 pmol/L (16-fold reduction, p < 0.05), and the level of Cox-1 mRNA was reduced to 0.02+/-0.002 pmol/L (15-fold reduction, p < 0.05).	benzo(b)fluoranthene	29-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
9011588-7	1997	These results indicate that prostaglandin production in PMOs is regulated by alterations in both immunoreactive Cox-1 and Cox-2.	Prostaglandins	28-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-127
8995534-7	1997	We show a coordinate induction of both cPLA2 and COX-2 mRNA by pro-inflammatory cytokines which correlated with increased PGE2 release.	Dinoprostone	122-126	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-54
9055202-2	1997	The fluorescence of pyrene-monophosphatase is enhanced upon addition of the activating metal ions Co(II) and Mg(II).	Metals	87-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-104
9055202-5	1997	The phosphorescence emitted by eosin covalently linked to the protein is quenched by the addition of the activating cations Co(II) and Mg(II).	Eosine Yellowish-(YS)	31-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	124-130
8995534-3	1997	These enzymes catalyse the release of arachidonic acid which is then converted to prostaglandins by the cyclooxygenases (COX-1 and COX-2).	Arachidonic Acid	38-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-136
8995534-9	1997	In addition dexamethasone pretreatment significantly reduced both cPLA2 and COX-2 mRNA levels as well as PGE2 release following cytokine stimulation.	Dexamethasone	12-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-81
8995534-3	1997	These enzymes catalyse the release of arachidonic acid which is then converted to prostaglandins by the cyclooxygenases (COX-1 and COX-2).	Prostaglandins	82-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-136
8995534-11	1997	Furthermore we show that a major mechanism of glucocorticoid action in preventing prostaglandin release occurs by suppression of cPLA2 and COX-2 mRNA levels.	Prostaglandins	82-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-144
8912844-4	1996	Estrogen-dependent MCF-7 cells exhibited a relatively high expression of COX-1; COX-2 was barely detectable but was transiently induced by treatment with TPA (10 nM).	Tetradecanoylphorbol Acetate	154-157	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-85
18475763-2	1997	Anti-HSV effect of complexes of Co(II) with aminoacids Lys and Ser was also found.	Lysine	55-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-37
18475763-2	1997	Anti-HSV effect of complexes of Co(II) with aminoacids Lys and Ser was also found.	Serine	63-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-37
9034217-3	1997	The kinetics of R6 hexamer disruption were studied by extraction of Co(II) with EDTA.	Edetic Acid	80-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-74
9034217-7	1997	The extraction of Co(II) from both hexameric complexes by EDTA chelation is slow at pH 8.0 and highly dependent on ligand concentration.	Edetic Acid	58-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-24
9263351-3	1997	Aspirin is an approximately 150- to 200-fold more potent inhibitor of the (constitutive) isoform of the platelet enzyme (COX-1) than the (inducible) isoform (COX-2) which is expressed by cytokines, inflammatory stimuli, and some growth factors.	Aspirin	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	158-163
9263351-4	1997	This explains the different dosage requirements of aspirin as an antithrombotic (COX-1) and an anti-inflammatory drug (COX-2), respectively.	Aspirin	51-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-124
9032578-3	1996	In contrast, the induced COX 2 enzyme appears mainly after cell injury and inflammation and is responsible for generating the prostaglandins which mediate inflammatory episodes.	Prostaglandins	126-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-30
9032579-2	1996	Expression of COX-2 can be induced locally by inflammatory stimuli and appears coincident with local prostaglandin (PG) production.	Prostaglandins	101-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
9032579-2	1996	Expression of COX-2 can be induced locally by inflammatory stimuli and appears coincident with local prostaglandin (PG) production.	Prostaglandins	116-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
9032579-4	1996	Inhibitors of COX-2 are as active as non-selective NSAIDs and inhibit PG synthesis in inflammatory cells.	Prostaglandins	70-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
9032580-11	1996	The selective COX-2 inhibitor, flosulide, is significantly better tolerated and causes less gastric mucosal damage than naproxen when given for two weeks.	flosulide	31-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
8939949-3	1996	While COX-1 expression is largely constitutive, COX-2 is highly regulated by cytokines, growth factors, and tumor promoters, such as the protein kinase C (PKC) activator, phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	171-202	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-53
8939949-6	1996	Similarly, phosphorylation of the corresponding COX-2 peptides was not observed using either the phosphocellulose paper absorption method or electrospray mass spectrometry.	phosphocellulose	97-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-53
8912844-6	1996	This high COX-2 expression applied to both the protein and mRNA and increased further over a relatively long period of time in the presence of TPA.	Tetradecanoylphorbol Acetate	143-146	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
8912844-7	1996	The extent of PGE2 production by the two cell lines correlated well with the level of COX-2 protein, suggesting that this isoform is required for both their constitutive and mitogen-induced PGE2 synthesis.	Dinoprostone	14-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-91
8912844-7	1996	The extent of PGE2 production by the two cell lines correlated well with the level of COX-2 protein, suggesting that this isoform is required for both their constitutive and mitogen-induced PGE2 synthesis.	Dinoprostone	190-194	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-91
8781445-7	1996	The transfer was accompanied by a reduction of the Co(III) to Co(II), indicating that NO+ (nitrosonium) was the leaving group.	nitrosonium)	91-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-68
18966651-2	1996	The BTAC reacts with Co(II) in the presence of Triton-X100 surfactant forming a green complex with maximum absorption at 615 nm.	2-(2-benzothiazolylazo)-p-cresol	4-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-27
18966651-2	1996	The BTAC reacts with Co(II) in the presence of Triton-X100 surfactant forming a green complex with maximum absorption at 615 nm.	Octoxynol	47-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-27
11666780-9	1996	However, decomposition of CoCrV takes place through partial depolymerization of decavanadate species and formation of Co(II)Cr(2)O(4) and Co(II)(2)V(2)O(7), without intermediate formation of Cr(VI) species.	cocrv	26-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-124
11666780-9	1996	However, decomposition of CoCrV takes place through partial depolymerization of decavanadate species and formation of Co(II)Cr(2)O(4) and Co(II)(2)V(2)O(7), without intermediate formation of Cr(VI) species.	hippuric acid	127-130	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-124
11666780-9	1996	However, decomposition of CoCrV takes place through partial depolymerization of decavanadate species and formation of Co(II)Cr(2)O(4) and Co(II)(2)V(2)O(7), without intermediate formation of Cr(VI) species.	Chromium	28-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-124
8905250-4	1996	The inducible enzyme COX-2 is responsible for the generation of prostaglandins at sites of tissue inflammation and its inhibition is associated with an anti-inflammatory action.	Prostaglandins	64-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-26
8757337-3	1996	An inducible form of cyclo-oxygenase (COX 2) was demonstrated in astrocytes and microglia after IL-1 beta plus IFN-gamma stimulation; since 1) large amounts of PGF2 alpha were released; 2) PGF2 alpha secretion required protein synthesis and was blocked by indomethacin; and 3) the response was delayed and persistent.	Dinoprost	160-164	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-43
9372101-2	1996	Recent studies suggest that aspirin"s anti-inflammatory effects are mediated via inhibition of an inducible isoform of cyclooxygenase in inflammatory cells (COX-2) and through blockade of the nuclear transcription factor, NF-kappa B.	Aspirin	28-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	157-162
8757337-3	1996	An inducible form of cyclo-oxygenase (COX 2) was demonstrated in astrocytes and microglia after IL-1 beta plus IFN-gamma stimulation; since 1) large amounts of PGF2 alpha were released; 2) PGF2 alpha secretion required protein synthesis and was blocked by indomethacin; and 3) the response was delayed and persistent.	Dinoprost	189-193	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-43
8757337-3	1996	An inducible form of cyclo-oxygenase (COX 2) was demonstrated in astrocytes and microglia after IL-1 beta plus IFN-gamma stimulation; since 1) large amounts of PGF2 alpha were released; 2) PGF2 alpha secretion required protein synthesis and was blocked by indomethacin; and 3) the response was delayed and persistent.	Indomethacin	256-268	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-43
8718891-1	1996	The steady state tryptophan fluorescence of apo-human cyclooxygenase-2 (hCox-2) is quenched approximately 40%-50% by the slow binding inhibitors diclofenac, indomethacin, ketoprofen, NS-398, and DuP-697.	Tryptophan	17-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-78
8918053-6	1996	Constitutive and upregulated constitutive COX (COX-1) expression and inducible COX (COX-2) expression are important in PGI2 production required for the physiologic and pathologic defense of blood vessels and blood fluidity.	Epoprostenol	119-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-89
8718891-1	1996	The steady state tryptophan fluorescence of apo-human cyclooxygenase-2 (hCox-2) is quenched approximately 40%-50% by the slow binding inhibitors diclofenac, indomethacin, ketoprofen, NS-398, and DuP-697.	Diclofenac	145-155	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-78
8718891-1	1996	The steady state tryptophan fluorescence of apo-human cyclooxygenase-2 (hCox-2) is quenched approximately 40%-50% by the slow binding inhibitors diclofenac, indomethacin, ketoprofen, NS-398, and DuP-697.	Indomethacin	157-169	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-78
8780708-4	1996	Macrophages pre-treated with acetylsalicylic acid, indomethacin, naproxen or NS-398 and stimulated with LPS showed a marked inhibition on PGE2 production but not on COX-1 or COX-2 mRNA and protein expression.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	77-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	174-179
8718891-1	1996	The steady state tryptophan fluorescence of apo-human cyclooxygenase-2 (hCox-2) is quenched approximately 40%-50% by the slow binding inhibitors diclofenac, indomethacin, ketoprofen, NS-398, and DuP-697.	Ketoprofen	171-181	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-78
8780726-8	1996	Acetylsalicylic acid (aspirin) and NS-398 (potent COX-2 inhibitor) also inhibited PGD2 release by 85 and 45% respectively.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	35-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-55
8718891-1	1996	The steady state tryptophan fluorescence of apo-human cyclooxygenase-2 (hCox-2) is quenched approximately 40%-50% by the slow binding inhibitors diclofenac, indomethacin, ketoprofen, NS-398, and DuP-697.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	183-189	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-78
8780726-8	1996	Acetylsalicylic acid (aspirin) and NS-398 (potent COX-2 inhibitor) also inhibited PGD2 release by 85 and 45% respectively.	Prostaglandin D2	82-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-55
8718891-10	1996	ASA-acetylated apo-hCox-2 shows the same fluorescence-quenching behavior in the presence of most of the above inhibitors.	Aspirin	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-25
8832430-5	1996	The conversion of digoxigenin, digitoxigenin and their digitoxosides is accelerated by Cu(II) acetate or Co(II) nitrate in H2SO4.	Digoxigenin	18-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-111
8870111-3	1996	The emerging picture is that COX1 is responsible for maintaining prostaglandin synthesis in the gastric mucosa, platelets, and kidney, whereas COX2 is responsible for prostaglandin production in inflamed tissues, including rheumatoid arthritis (RA) synovium.	Prostaglandins	167-180	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	143-147
11667375-7	1996	A key intermediate in this oxidation is believed to be the phthalimide N-oxyl radical generated from NHPI and molecular oxygen using a Co(II) species.	phthalimide n-oxyl radical	59-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-141
11667375-7	1996	A key intermediate in this oxidation is believed to be the phthalimide N-oxyl radical generated from NHPI and molecular oxygen using a Co(II) species.	Oxygen	120-126	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-141
8763845-4	1996	Neither of these subsequent processes are inhibited by the addition of O2 up to a concentration of 0.5 mmol l-1 suggesting that the HSC action of SN 24771 most likely arises from a mechanism other than simple redox cycling between the Co(III) and Co(II) forms by O2.	Tin	146-148	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	247-253
8663121-2	1996	This suggests that clinically useful NSAIDs inhibit pro-inflammatory prostaglandins (PGs) derived from the activity of COX-2, as well as PGs in tissues like the stomach and kidney (via COX-1).	Prostaglandins	69-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-124
8663121-2	1996	This suggests that clinically useful NSAIDs inhibit pro-inflammatory prostaglandins (PGs) derived from the activity of COX-2, as well as PGs in tissues like the stomach and kidney (via COX-1).	Prostaglandins	85-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-124
8663121-3	1996	A new class of compounds has recently been developed (SC-58125) that have a high degree of selectivity for the inducible form of cyxlooxygenase (COX-2) over the constitutive form (COX-1).	1-((4-methylsulfonyl)phenyl)-3-trifluoromethyl-5-(4-fluorophenyl)pyrazole	54-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-150
8663121-8	1996	The single amino acid change of valine 509 to isoleucine confers selectivity of COX-2 inhibitors in the class of SC-58125 and others of the same class (SC-236, NS-398), while commonly used NSAIDs such as indomethacin showed no change in selectivity.	1-((4-methylsulfonyl)phenyl)-3-trifluoromethyl-5-(4-fluorophenyl)pyrazole	113-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-85
8663121-8	1996	The single amino acid change of valine 509 to isoleucine confers selectivity of COX-2 inhibitors in the class of SC-58125 and others of the same class (SC-236, NS-398), while commonly used NSAIDs such as indomethacin showed no change in selectivity.	4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide	152-158	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-85
8663121-8	1996	The single amino acid change of valine 509 to isoleucine confers selectivity of COX-2 inhibitors in the class of SC-58125 and others of the same class (SC-236, NS-398), while commonly used NSAIDs such as indomethacin showed no change in selectivity.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	160-166	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-85
8663121-8	1996	The single amino acid change of valine 509 to isoleucine confers selectivity of COX-2 inhibitors in the class of SC-58125 and others of the same class (SC-236, NS-398), while commonly used NSAIDs such as indomethacin showed no change in selectivity.	Indomethacin	204-216	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-85
8832430-5	1996	The conversion of digoxigenin, digitoxigenin and their digitoxosides is accelerated by Cu(II) acetate or Co(II) nitrate in H2SO4.	Digitoxigenin	31-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-111
8832430-5	1996	The conversion of digoxigenin, digitoxigenin and their digitoxosides is accelerated by Cu(II) acetate or Co(II) nitrate in H2SO4.	Digitoxin	55-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-111
8832430-5	1996	The conversion of digoxigenin, digitoxigenin and their digitoxosides is accelerated by Cu(II) acetate or Co(II) nitrate in H2SO4.	sulfuric acid	123-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-111
11666569-4	1996	A Co(II)-induced isomerization and the S(H)2 mechanism are ruled out on the basis of the known reactivity of RCbi(+) and product analysis.	rcbi	109-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	2-9
15045339-2	1996	Co(II) is selectively recovered from an acidified sample with 8-quinolinol immobilized on silica gel.	Oxyquinoline	62-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
8764139-8	1996	We further show that the tyrosine kinase inhibitors genistein and herbimycin A prevent IL-1 beta plus IFN-gamma-induced expression of COX-2 and iNOS and the production of PGE2 and nitric oxide by human islets.	Genistein	52-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-139
8764139-8	1996	We further show that the tyrosine kinase inhibitors genistein and herbimycin A prevent IL-1 beta plus IFN-gamma-induced expression of COX-2 and iNOS and the production of PGE2 and nitric oxide by human islets.	herbimycin	66-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-139
15045339-2	1996	Co(II) is selectively recovered from an acidified sample with 8-quinolinol immobilized on silica gel.	Silica Gel	90-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
8612694-1	1996	Epidermal expression of the two isoforms of the prostaglandin H-generating cyclooxygenase (COX-1 and COX-2) was evaluated both by immunohistochemistry performed on human and mouse skin biopsy sections and by Western blotting of protein extracts from cultured human neonatal foreskin keratinocytes.	Prostaglandins H	48-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-106
8653697-3	1996	Overexpression of Cox-2 is associated with both human colon cancers and suppression of apoptosis in cultured epithelia] cells, an activity that is reversed by the nonsteroidal anti-inflammatory drug, sulindac sulfide.	sulindac sulfide	200-216	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-23
8818017-2	1996	In this work the influence of the presence of certain metallic elements (Ca(II), Fe(III), Mn(II), Zn(II), Cd(II), Ni(II) and Co(II)) in trace amounts on the polymorphism of tolbutamide is described.	ferric sulfate	81-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-131
8818017-2	1996	In this work the influence of the presence of certain metallic elements (Ca(II), Fe(III), Mn(II), Zn(II), Cd(II), Ni(II) and Co(II)) in trace amounts on the polymorphism of tolbutamide is described.	Tolbutamide	173-184	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-131
8612694-7	1996	However, following acetone treatment, there is a marked increase in COX-1 expression as well as the appearance of significant COX-2 immunostaining in the basal layer.	Acetone	19-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-131
8809635-1	1996	The stereoselective inhibition of inducible cyclooxygenase (COX-2) by chiral nonsteroidal antiinflammatory drugs (NSAIDs)--ketoprofen, flurbiprofen, and ketorolac--has been investigated.	Ketoprofen	123-133	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-65
8809635-1	1996	The stereoselective inhibition of inducible cyclooxygenase (COX-2) by chiral nonsteroidal antiinflammatory drugs (NSAIDs)--ketoprofen, flurbiprofen, and ketorolac--has been investigated.	Flurbiprofen	135-147	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-65
8809635-1	1996	The stereoselective inhibition of inducible cyclooxygenase (COX-2) by chiral nonsteroidal antiinflammatory drugs (NSAIDs)--ketoprofen, flurbiprofen, and ketorolac--has been investigated.	Ketorolac	153-162	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-65
8809635-4	1996	In the whole blood model, both isoenzymes were inhibited by S-enantiomers with equal potency but S-ketoprofen was the most active on COX-2 (IC50 = 0.024 mumol/L).	Ketoprofen	97-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	133-138
8612694-4	1996	In human keratinocyte cultures, raising the extracellular calcium concentration, a recognized stimulus for keratinocyte differentiation, leads to an increased expression of both COX-2 protein and mRNA; expression of COX-1 protein, however, shows no significant alteration in response to calcium.	Calcium	58-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	178-183
8602840-4	1996	The activity of COX-2 was assessed by measuring the accumulation of PGE2 by radioimmunoassay.	Dinoprostone	68-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-21
8785352-3	1996	The transition metal cations that effectively bind DNA to mica are Ni(II), Co(II), and Zn(II), which have ionic radii from 0.69 to 0.74 A.	Metals	15-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-81
8785352-3	1996	The transition metal cations that effectively bind DNA to mica are Ni(II), Co(II), and Zn(II), which have ionic radii from 0.69 to 0.74 A.	mica	58-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-81
8785352-10	1996	Ni(II), Co(II), and Zn(II) have anomalously high enthalpies of hydration that may relate to their ability to bind DNA to mica.	mica	121-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	8-14
8602840-8	1996	The increased COX-2 protein and activity in response to IL-1beta (10 ng/ml) was inhibited by the tyrosine kinase inhibitors tyrphostin (AG126; 0.015 to 15 microM) or erbstatin (0.004 to 4 microM).	Tyrphostins	124-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
8602840-8	1996	The increased COX-2 protein and activity in response to IL-1beta (10 ng/ml) was inhibited by the tyrosine kinase inhibitors tyrphostin (AG126; 0.015 to 15 microM) or erbstatin (0.004 to 4 microM).	AG 127	136-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
8602840-8	1996	The increased COX-2 protein and activity in response to IL-1beta (10 ng/ml) was inhibited by the tyrosine kinase inhibitors tyrphostin (AG126; 0.015 to 15 microM) or erbstatin (0.004 to 4 microM).	erbstatin	166-175	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
8852524-5	1996	In particular, nimesulide is selective for COX-2 and displays additional properties in terms of its effects on inflammatory mediator synthesis and release.	nimesulide	15-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
8882591-4	1996	The exaggerated release of PGE2 was attenuated by cycloheximide, an inhibitor of protein synthesis or by dexamethasone, a steroid known to inhibit the induction of cyclo-oxygenase (COX-2).	Dinoprostone	27-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	181-186
8882591-4	1996	The exaggerated release of PGE2 was attenuated by cycloheximide, an inhibitor of protein synthesis or by dexamethasone, a steroid known to inhibit the induction of cyclo-oxygenase (COX-2).	Cycloheximide	50-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	181-186
8882591-4	1996	The exaggerated release of PGE2 was attenuated by cycloheximide, an inhibitor of protein synthesis or by dexamethasone, a steroid known to inhibit the induction of cyclo-oxygenase (COX-2).	Dexamethasone	105-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	181-186
8882591-4	1996	The exaggerated release of PGE2 was attenuated by cycloheximide, an inhibitor of protein synthesis or by dexamethasone, a steroid known to inhibit the induction of cyclo-oxygenase (COX-2).	Steroids	122-129	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	181-186
8882591-14	1996	Indomethacin (1 microM), a non-selective COX-1 and COX-2 inhibitor, completely inhibited PGE2 release in the normal contralateral as well as in the hydronephrotic kidney.	Indomethacin	0-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-56
8882591-16	1996	We suggest that renal prostaglandin production in the normal kidney is driven by the activity of constitutive COX-1 while at sites of inflammation, such as the hydronephrotic kidney, there is induction of COX-2 that can be blocked selectively by anti-inflammatory glucocorticoids or selective COX-2 inhibitors.	Prostaglandins	22-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	205-210
8882591-16	1996	We suggest that renal prostaglandin production in the normal kidney is driven by the activity of constitutive COX-1 while at sites of inflammation, such as the hydronephrotic kidney, there is induction of COX-2 that can be blocked selectively by anti-inflammatory glucocorticoids or selective COX-2 inhibitors.	Prostaglandins	22-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	293-298
10479422-5	1996	The EDTA complexes of the divalent metals Ca, Zn, Ni, Cu, Co(II), and Pb, which are quinquedentate in solution (free donor atoms bound to the metal ion), all showed the same ligand-like adsorption behavior.	Edetic Acid	4-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
8907587-6	1996	Five experimental compounds CGP-28238, Dup-697, NS-398, SC-58125 and L-745,337, have a greater selectivity for Cox-2.	Nitrogen	48-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	111-116
8907587-7	1996	Indomethacin at a single oral dose (25 mg) inhibited approximately 90% the whole blood Cox-2 and Cox-1 activities ex vivo in healthy subjects.	Indomethacin	0-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-92
11666222-8	1996	The following stability sequence has been obtained: In(III) > Ga(III) >> Ni(II) > Zn(II) > Cd(II) > Pb(II) > Co(II).	Nickel(2+)	82-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	130-136
11666222-8	1996	The following stability sequence has been obtained: In(III) > Ga(III) >> Ni(II) > Zn(II) > Cd(II) > Pb(II) > Co(II).	Zinc	94-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	130-136
11666222-8	1996	The following stability sequence has been obtained: In(III) > Ga(III) >> Ni(II) > Zn(II) > Cd(II) > Pb(II) > Co(II).	cd(ii)	106-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	130-136
10479422-5	1996	The EDTA complexes of the divalent metals Ca, Zn, Ni, Cu, Co(II), and Pb, which are quinquedentate in solution (free donor atoms bound to the metal ion), all showed the same ligand-like adsorption behavior.	Metals	35-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
18475756-3	1996	Together with the arsonolipids previously investigated, the active compounds of this series - the "lipothioarsenites"- constitute a novel class of CA inhibitors that bind to the metal ion within the enzyme active site, as proved by changes in the electronic spectra of adducts of such inhibitors with Co(II)CA.	lipothioarsenites	99-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	301-306
8568912-2	1996	Incubation of Co(II) with beta-alanyl-3-methyl-L-histidine (anserine) and H2O2 generated .OH radicals.	Anserine	26-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-20
8568912-2	1996	Incubation of Co(II) with beta-alanyl-3-methyl-L-histidine (anserine) and H2O2 generated .OH radicals.	Anserine	60-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-20
8568912-2	1996	Incubation of Co(II) with beta-alanyl-3-methyl-L-histidine (anserine) and H2O2 generated .OH radicals.	Hydrogen Peroxide	74-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-20
8568912-2	1996	Incubation of Co(II) with beta-alanyl-3-methyl-L-histidine (anserine) and H2O2 generated .OH radicals.	.oh radicals	89-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-20
8568912-3	1996	Omission of any one component sharply reduced the amount of .OH radicals generated, indicating that anserine modulated the oxidation potential of Co(II) to enhance its capability to generate .OH radicals from H2O2.	.oh radicals	60-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	146-152
8568912-3	1996	Omission of any one component sharply reduced the amount of .OH radicals generated, indicating that anserine modulated the oxidation potential of Co(II) to enhance its capability to generate .OH radicals from H2O2.	Anserine	100-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	146-152
8568912-3	1996	Omission of any one component sharply reduced the amount of .OH radicals generated, indicating that anserine modulated the oxidation potential of Co(II) to enhance its capability to generate .OH radicals from H2O2.	.oh radicals	191-203	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	146-152
8568912-3	1996	Omission of any one component sharply reduced the amount of .OH radicals generated, indicating that anserine modulated the oxidation potential of Co(II) to enhance its capability to generate .OH radicals from H2O2.	Hydrogen Peroxide	209-213	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	146-152
8568912-6	1996	Electrophoretic assays using both lambda Hind III linear DNA and PM2 supercoiled DNA showed that .OH radicals generated from a mixture of Co(II), H2O2, and anserine caused DNA strand breaks.	.oh radicals	97-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	138-144
8568912-7	1996	A mixture of Co(II), H2O2, and 1,10-phenanthroline also caused DNA strand breaks, which were inhibited by sodium azide, indicating that 1O2 was involved in DNA damage.	Sodium Azide	106-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-19
8568912-7	1996	A mixture of Co(II), H2O2, and 1,10-phenanthroline also caused DNA strand breaks, which were inhibited by sodium azide, indicating that 1O2 was involved in DNA damage.	CHEBI:63768	136-139	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-19
8568912-8	1996	HPLC measurements showed that .OH radicals and 1O2 generated by Co(II) reactions caused 2"-deoxyguanosine hydroxylation to form 8-hydroxy-2"-deoxyguanosine.	oh radicals	31-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-70
8568912-8	1996	HPLC measurements showed that .OH radicals and 1O2 generated by Co(II) reactions caused 2"-deoxyguanosine hydroxylation to form 8-hydroxy-2"-deoxyguanosine.	CHEBI:63768	47-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-70
8568912-8	1996	HPLC measurements showed that .OH radicals and 1O2 generated by Co(II) reactions caused 2"-deoxyguanosine hydroxylation to form 8-hydroxy-2"-deoxyguanosine.	Deoxyguanosine	88-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-70
8568912-8	1996	HPLC measurements showed that .OH radicals and 1O2 generated by Co(II) reactions caused 2"-deoxyguanosine hydroxylation to form 8-hydroxy-2"-deoxyguanosine.	8-ohdg	128-155	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-70
8568912-9	1996	ESR spin trapping measurements provided evidence for 1O2 generation by Co(II) from H2O2 in the presence of 1,10-phenanthroline.	Hydrogen Peroxide	83-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-77
8568912-9	1996	ESR spin trapping measurements provided evidence for 1O2 generation by Co(II) from H2O2 in the presence of 1,10-phenanthroline.	1,10-phenanthroline	107-126	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-77
8568912-10	1996	The results indicate that the oxidation potential of Co(II) can be modulated by chelators to facilitate its generation of reactive oxygen species from H2O2.	Reactive Oxygen Species	122-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-59
8568912-10	1996	The results indicate that the oxidation potential of Co(II) can be modulated by chelators to facilitate its generation of reactive oxygen species from H2O2.	Hydrogen Peroxide	151-155	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-59
8582034-7	1996	Of the two isoforms of cyclooxygenase (COX-1 and COX-2), COX-1 activity was inhibited by oxime-2 and 4"-piperidinoacetophenone oxime (oxime-3) with IC50 values of 50 and 130 microM, respectively, while COX-2 activity was not inhibited.	Oximes	89-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-54
8582034-7	1996	Of the two isoforms of cyclooxygenase (COX-1 and COX-2), COX-1 activity was inhibited by oxime-2 and 4"-piperidinoacetophenone oxime (oxime-3) with IC50 values of 50 and 130 microM, respectively, while COX-2 activity was not inhibited.	Oximes	89-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	202-207
8582034-7	1996	Of the two isoforms of cyclooxygenase (COX-1 and COX-2), COX-1 activity was inhibited by oxime-2 and 4"-piperidinoacetophenone oxime (oxime-3) with IC50 values of 50 and 130 microM, respectively, while COX-2 activity was not inhibited.	2 and	95-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-54
8582034-7	1996	Of the two isoforms of cyclooxygenase (COX-1 and COX-2), COX-1 activity was inhibited by oxime-2 and 4"-piperidinoacetophenone oxime (oxime-3) with IC50 values of 50 and 130 microM, respectively, while COX-2 activity was not inhibited.	2 and	95-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	202-207
8582034-7	1996	Of the two isoforms of cyclooxygenase (COX-1 and COX-2), COX-1 activity was inhibited by oxime-2 and 4"-piperidinoacetophenone oxime (oxime-3) with IC50 values of 50 and 130 microM, respectively, while COX-2 activity was not inhibited.	4"-piperidinoacetophenone oxime	101-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-54
8582034-7	1996	Of the two isoforms of cyclooxygenase (COX-1 and COX-2), COX-1 activity was inhibited by oxime-2 and 4"-piperidinoacetophenone oxime (oxime-3) with IC50 values of 50 and 130 microM, respectively, while COX-2 activity was not inhibited.	4"-piperidinoacetophenone oxime	101-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	202-207
8582034-7	1996	Of the two isoforms of cyclooxygenase (COX-1 and COX-2), COX-1 activity was inhibited by oxime-2 and 4"-piperidinoacetophenone oxime (oxime-3) with IC50 values of 50 and 130 microM, respectively, while COX-2 activity was not inhibited.	Oximes	127-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-54
8582034-7	1996	Of the two isoforms of cyclooxygenase (COX-1 and COX-2), COX-1 activity was inhibited by oxime-2 and 4"-piperidinoacetophenone oxime (oxime-3) with IC50 values of 50 and 130 microM, respectively, while COX-2 activity was not inhibited.	Oximes	127-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	202-207
8568912-0	1996	Generation of reactive oxygen species by Co(II) from H2O2 in the presence of chelators in relation to DNA damage and 2"-deoxyguanosine hydroxylation.	Reactive Oxygen Species	14-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-47
8568912-0	1996	Generation of reactive oxygen species by Co(II) from H2O2 in the presence of chelators in relation to DNA damage and 2"-deoxyguanosine hydroxylation.	Hydrogen Peroxide	53-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-47
8568912-0	1996	Generation of reactive oxygen species by Co(II) from H2O2 in the presence of chelators in relation to DNA damage and 2"-deoxyguanosine hydroxylation.	Deoxyguanosine	117-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-47
8568912-1	1996	The generation of reactive oxygen species by Co(II) from H2O2 in the presence of chelators and related DNA damage was investigated by electron spin resonance (ESR), electrophoretic assays, and high-performance liquid chromatography (HPLC).	Reactive Oxygen Species	18-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-51
8568912-1	1996	The generation of reactive oxygen species by Co(II) from H2O2 in the presence of chelators and related DNA damage was investigated by electron spin resonance (ESR), electrophoretic assays, and high-performance liquid chromatography (HPLC).	Hydrogen Peroxide	57-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-51
18475756-3	1996	Together with the arsonolipids previously investigated, the active compounds of this series - the "lipothioarsenites"- constitute a novel class of CA inhibitors that bind to the metal ion within the enzyme active site, as proved by changes in the electronic spectra of adducts of such inhibitors with Co(II)CA.	Metals	178-183	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	301-306
8628981-8	1996	The most clinically advanced is meloxicam, which consistently demonstrates higher activity against COX-2 than COX-1 in several test systems.	Meloxicam	32-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-104
8594615-6	1996	The expression of COX-2 results in the overproduction of the proinflammatory prostaglandins and thromboxanes.	Prostaglandins	77-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-23
8594615-6	1996	The expression of COX-2 results in the overproduction of the proinflammatory prostaglandins and thromboxanes.	Thromboxanes	96-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-23
8595067-3	1995	Nimesulide (CAS 51803-78-2) has been shown to inhibit with high selectivity COX-2 without affecting COX-1 activity, so explaining the previous observations about the selectivity of the anti-prostaglandin effect of the drug.	nimesulide	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-81
8595066-12	1995	With the in vitro assay, nimesulide (0.01 to 100 mumol/l) did not inhibit PGE formation by COX-1 but caused a concentration-related inhibition of PGE formation by COX-2 (4-60%).	nimesulide	25-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	163-168
8595066-12	1995	With the in vitro assay, nimesulide (0.01 to 100 mumol/l) did not inhibit PGE formation by COX-1 but caused a concentration-related inhibition of PGE formation by COX-2 (4-60%).	Prostaglandins E	146-149	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	163-168
8628979-6	1996	This improved safety profile is likely to be due to meloxicam"s selective inhibition of COX-2 relative to COX-1.	Meloxicam	52-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-93
8633785-9	1995	The ANN method was also used to resolve mixtures of Fe(III), Co(II), and Zn(II) by displacement from their EGTA complexes with 4-(2-pyridylazo)resorcinol (PAR) using a stopped-flow injection assembly including a diode array detector.	Egtazic Acid	107-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-66
8633785-9	1995	The ANN method was also used to resolve mixtures of Fe(III), Co(II), and Zn(II) by displacement from their EGTA complexes with 4-(2-pyridylazo)resorcinol (PAR) using a stopped-flow injection assembly including a diode array detector.	4-(2-pyridylazo)resorcinol	127-153	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-66
8633785-9	1995	The ANN method was also used to resolve mixtures of Fe(III), Co(II), and Zn(II) by displacement from their EGTA complexes with 4-(2-pyridylazo)resorcinol (PAR) using a stopped-flow injection assembly including a diode array detector.	4-(2-pyridylazo)resorcinol	155-158	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-66
8526850-1	1995	In addition to a constitutive cyclo-oxygenase (Cox-1), human endothelial cells also possess an inducible cyclo-oxygenase (Cox-2) which plays an important role in the regulation of the synthesis of prostacyclin (prostaglandin I2).	Epoprostenol	197-209	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-127
8526850-1	1995	In addition to a constitutive cyclo-oxygenase (Cox-1), human endothelial cells also possess an inducible cyclo-oxygenase (Cox-2) which plays an important role in the regulation of the synthesis of prostacyclin (prostaglandin I2).	Epoprostenol	211-227	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-127
8526850-2	1995	Cox-2 is regulated and expressed in large quantities upon activation of the cells by inducers such as phorbol myristate acetate (PMA), an activator of protein kinase C (PKC), or interleukin-1 alpha.	Tetradecanoylphorbol Acetate	102-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
8526850-2	1995	Cox-2 is regulated and expressed in large quantities upon activation of the cells by inducers such as phorbol myristate acetate (PMA), an activator of protein kinase C (PKC), or interleukin-1 alpha.	Tetradecanoylphorbol Acetate	129-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
8526850-5	1995	This stimulation was accompanied by the induction of Cox-2 protein, detectable after stimulation for 1 h, which is consistent with an increase in activity reflected by prostacyclin synthesis; no variation in the expression of Cox-1 could be observed.	Epoprostenol	168-180	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-58
8595067-3	1995	Nimesulide (CAS 51803-78-2) has been shown to inhibit with high selectivity COX-2 without affecting COX-1 activity, so explaining the previous observations about the selectivity of the anti-prostaglandin effect of the drug.	Calcium	12-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-81
8595067-5	1995	The time dependence of COX-2 inhibitors might afford some clues to a better understanding of the mechanism of COX-2 selective inhibition, on the discrepancy between some authors about the potency of the drug and on the relationship between COX-2 inhibition and inhibition of superoxide anion production, an event also characterized by a time dependence.	Superoxides	275-291	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-28
8595067-5	1995	The time dependence of COX-2 inhibitors might afford some clues to a better understanding of the mechanism of COX-2 selective inhibition, on the discrepancy between some authors about the potency of the drug and on the relationship between COX-2 inhibition and inhibition of superoxide anion production, an event also characterized by a time dependence.	Superoxides	275-291	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-115
8595067-5	1995	The time dependence of COX-2 inhibitors might afford some clues to a better understanding of the mechanism of COX-2 selective inhibition, on the discrepancy between some authors about the potency of the drug and on the relationship between COX-2 inhibition and inhibition of superoxide anion production, an event also characterized by a time dependence.	Superoxides	275-291	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-115
8595067-6	1995	So we evaluated the time dependency of the effect of nimesulide on COX-1 and COX-2.	nimesulide	53-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-82
8595067-8	1995	Nimesulide inhibited COX-2 activity in a concentration-dependent manner.	nimesulide	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-26
8595067-11	1995	In conclusion nimesulide"s selective inhibitory effect on COX-2 is time-dependent whereas its weak effect on COX-1 is not time-dependent.	nimesulide	14-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
8595067-12	1995	This observation agrees with the time dependence effect of COX-2 reported by other workers with NS-398 (N-(2-cyclohexyl-oxy-4-nitrophenyl)methane sulphonamide) and with flosulide and explains the different values of IC50 reported by other workers.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	96-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-64
8595067-12	1995	This observation agrees with the time dependence effect of COX-2 reported by other workers with NS-398 (N-(2-cyclohexyl-oxy-4-nitrophenyl)methane sulphonamide) and with flosulide and explains the different values of IC50 reported by other workers.	n-(2-cyclohexyl-oxy-4-nitrophenyl)methane sulphonamide	104-158	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-64
8543370-3	1995	The increased COX-2 mRNA levels were accompanied by enhanced PGE2 formation.	Dinoprostone	61-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
8543370-4	1995	The phorbol, 12-myristate 13-acetate (PMA), known to stimulate protein kinase C (PKC), also induced expression of COX-2 mRNA.	phorbol	4-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-119
8595067-12	1995	This observation agrees with the time dependence effect of COX-2 reported by other workers with NS-398 (N-(2-cyclohexyl-oxy-4-nitrophenyl)methane sulphonamide) and with flosulide and explains the different values of IC50 reported by other workers.	flosulide	169-178	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-64
8595067-13	1995	Nimesulide shares with other sulfanilide-like drugs the time dependence of its selective effect on COX-2.	nimesulide	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-104
8543370-4	1995	The phorbol, 12-myristate 13-acetate (PMA), known to stimulate protein kinase C (PKC), also induced expression of COX-2 mRNA.	12-myristate 13-acetate	13-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-119
8595067-13	1995	Nimesulide shares with other sulfanilide-like drugs the time dependence of its selective effect on COX-2.	sulfanilide	29-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-104
8543370-4	1995	The phorbol, 12-myristate 13-acetate (PMA), known to stimulate protein kinase C (PKC), also induced expression of COX-2 mRNA.	Tetradecanoylphorbol Acetate	38-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-119
8526991-1	1995	PROBLEM: The purpose of this study was to examine the hypothesis that interleukin-1 beta (IL-1 beta)-elicited increases in decidual prostaglandin E2 and F2 alpha (PGE2 and PGF2 alpha) biosynthesis are due to the de novo expression of the inducible isoform of cyclooxygenase (i.e., COX-2).	Dinoprostone	132-148	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	281-286
8543370-6	1995	The anti-inflammatory steroid, dexamethasone (DEX) abolished the enhanced expression of COX-2 mRNA as well as PGE2 formation induced by IL-1 beta, PMA or the combination of IL-1 beta and PMA.	Steroids	22-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-93
8543370-6	1995	The anti-inflammatory steroid, dexamethasone (DEX) abolished the enhanced expression of COX-2 mRNA as well as PGE2 formation induced by IL-1 beta, PMA or the combination of IL-1 beta and PMA.	Dexamethasone	31-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-93
8543370-6	1995	The anti-inflammatory steroid, dexamethasone (DEX) abolished the enhanced expression of COX-2 mRNA as well as PGE2 formation induced by IL-1 beta, PMA or the combination of IL-1 beta and PMA.	Dexamethasone	46-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-93
8543370-6	1995	The anti-inflammatory steroid, dexamethasone (DEX) abolished the enhanced expression of COX-2 mRNA as well as PGE2 formation induced by IL-1 beta, PMA or the combination of IL-1 beta and PMA.	Tetradecanoylphorbol Acetate	147-150	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-93
8543370-7	1995	The study indicates that the IL-1 beta induced PGE2 formation is mediated by an enhanced gene expression of COX-2 in gingival fibroblasts suggesting that the enzyme COX-2 may play an important role in the regulation of prostanoid formation at inflammatory lesions in gingival tissue.	Dinoprostone	47-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-113
8543370-7	1995	The study indicates that the IL-1 beta induced PGE2 formation is mediated by an enhanced gene expression of COX-2 in gingival fibroblasts suggesting that the enzyme COX-2 may play an important role in the regulation of prostanoid formation at inflammatory lesions in gingival tissue.	Dinoprostone	47-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	165-170
8543370-7	1995	The study indicates that the IL-1 beta induced PGE2 formation is mediated by an enhanced gene expression of COX-2 in gingival fibroblasts suggesting that the enzyme COX-2 may play an important role in the regulation of prostanoid formation at inflammatory lesions in gingival tissue.	Prostaglandins	219-229	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-113
8543370-7	1995	The study indicates that the IL-1 beta induced PGE2 formation is mediated by an enhanced gene expression of COX-2 in gingival fibroblasts suggesting that the enzyme COX-2 may play an important role in the regulation of prostanoid formation at inflammatory lesions in gingival tissue.	Prostaglandins	219-229	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	165-170
22280290-0	1995	Nonreversible Adsorption of Divalent Metal Ions (MnII, CoII, NiII, CuII, and PbII) onto Goethite: Effects of Acidification, FeII Addition, and Picolinic Acid Addition.	goethite	88-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-59
11854834-3	1995	In inflammatory states, the newly discovered COX-2 is rapidly induced, and its activity accounts for the large amounts of PGs seen in inflammation.	Prostaglandins	122-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-50
11854834-5	1995	Selective inhibition of COX-2 expression explains at least in part the potent anti-inflammatory activity of steroids.	Steroids	108-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
11854834-6	1995	Anti-inflammatory activity of newly developed COX-2 inhibitors, such as NS-398 or SC-58125, suggest a new approach of inflammatory diseases with more efficacious NSAIDs essentially devoid of side effects such as stomach ulcers.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	72-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
11854834-6	1995	Anti-inflammatory activity of newly developed COX-2 inhibitors, such as NS-398 or SC-58125, suggest a new approach of inflammatory diseases with more efficacious NSAIDs essentially devoid of side effects such as stomach ulcers.	1-((4-methylsulfonyl)phenyl)-3-trifluoromethyl-5-(4-fluorophenyl)pyrazole	82-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
7641194-9	1995	These data suggest that the enhanced expression of the COX-2 gene in colon cancer tissues may contribute to the enhanced synthesis of prostaglandin E2 by the colon cancer tissues.	Dinoprostone	134-150	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-60
8526991-6	1995	When Northern blots of IL-1 beta-treated and control cells were probed with cDNAs encoding either COX-1 or COX-2 isoforms or an oligonucleotide probe encoding a portion of the human beta-actin, we detected a time- and dose-dependent increase in the steady-state levels of COX-2, but not COX-1 or beta-actin mRNA transcripts.	Oligonucleotides	128-143	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	272-277
8526991-7	1995	Moreover, the expression of COX-2 mRNA in IL-1 beta-stimulated cells was superinduced by preincubation with cycloheximide, but completely abolished by actinomycin D.	Cycloheximide	108-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
8526991-7	1995	Moreover, the expression of COX-2 mRNA in IL-1 beta-stimulated cells was superinduced by preincubation with cycloheximide, but completely abolished by actinomycin D.	Dactinomycin	151-164	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
8526991-8	1995	CONCLUSIONS: Taken together, the data suggest that COX-2 mRNA expression is largely responsible for the robust increase in PG formation seen in IL-1 beta-treated decidual cells.	pg	123-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-56
7706493-4	1995	In F-nl, incubation with the agonists PMA, LPS, or IL-1 increased COX activity and protein expression of the inducible form of COX, COX-2, and these responses were inhibited by coincubation with dexamethasone.	Tetradecanoylphorbol Acetate	38-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-137
7615528-6	1995	The formation of octadecanoids was inhibited in a dose-dependent manner by several COX inhibitors in both controls and IL-1 beta-treated cells, COX2 selective inhibitors being more effective on IL-1 beta-treated cells than on controls.	octadecanoids	17-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	144-148
7675826-5	1995	These results indicate that longer periods than 4 h are necessary to increase COX2 protein, suggesting that proteins other than COX2 are involved in early IL-1 alpha-induced PG synthesis.	Prostaglandins	174-176	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-82
7780157-7	1995	Moreover, the addition of cycloheximide (CHX) to LPS-stimulated monocytes resulted in a superinduction of COX-2 mRNA, whereas CHX almost abrogated the abilities of IL-10 and IL-4 to inhibit this gene expression.	Cycloheximide	26-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-111
7780157-7	1995	Moreover, the addition of cycloheximide (CHX) to LPS-stimulated monocytes resulted in a superinduction of COX-2 mRNA, whereas CHX almost abrogated the abilities of IL-10 and IL-4 to inhibit this gene expression.	Cycloheximide	41-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-111
7780157-8	1995	Experiments with actinomycin D showed that both cytokines accelerated the degradation of COX-2 mRNA.	Dactinomycin	17-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-94
22176402-2	1995	Complexation of Co(II) by Leonardite Humic Acid as a Function of pH and NaClO4 Concentration.	Humic Substances	37-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-21
22176402-2	1995	Complexation of Co(II) by Leonardite Humic Acid as a Function of pH and NaClO4 Concentration.	sodium perchlorate	72-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-21
7608556-4	1995	Dexamethasone completely inhibited IL-1-induced COX-2 mRNA expression.	Dexamethasone	0-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-53
7608556-5	1995	Analysis of signaling pathways showed that PMA and calcium ionophore A23187, but not dibutyryl cAMP, induced COX-2 mRNA.	Tetradecanoylphorbol Acetate	43-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-114
7608556-5	1995	Analysis of signaling pathways showed that PMA and calcium ionophore A23187, but not dibutyryl cAMP, induced COX-2 mRNA.	Calcium	51-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-114
7608556-5	1995	Analysis of signaling pathways showed that PMA and calcium ionophore A23187, but not dibutyryl cAMP, induced COX-2 mRNA.	Calcimycin	69-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-114
7608556-8	1995	COX-2 protein was detected at 71 kDa by Western blotting in IL-1-stimulated, and to almost similar levels in A23187-treated, cells.	Calcimycin	109-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
18966309-3	1995	The results show that most platinum metal ions, Co(II) and Cu(II) can form ternary mixed ligand complexes with MBTAE and salicylic acid.	Platinum	27-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-54
18966309-3	1995	The results show that most platinum metal ions, Co(II) and Cu(II) can form ternary mixed ligand complexes with MBTAE and salicylic acid.	Metals	36-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-54
18966309-3	1995	The results show that most platinum metal ions, Co(II) and Cu(II) can form ternary mixed ligand complexes with MBTAE and salicylic acid.	mbtae	111-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-54
18966309-3	1995	The results show that most platinum metal ions, Co(II) and Cu(II) can form ternary mixed ligand complexes with MBTAE and salicylic acid.	Salicylic Acid	121-135	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-54
7706493-4	1995	In F-nl, incubation with the agonists PMA, LPS, or IL-1 increased COX activity and protein expression of the inducible form of COX, COX-2, and these responses were inhibited by coincubation with dexamethasone.	Dexamethasone	195-208	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-137
7650864-1	1995	To elucidate the mechanism for the selective inhibition of prostaglandin E2 (PGE2) production in inflammatory tissue by T-614 (3-formylamino-7-methylsulfonylamino-6-phenoxy-4H-1-benzopyran-4-o ne), its effects on both the activity and the induction of cyclooxygenase (COX)-2 were investigated in vitro.	T 614	120-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	252-274
18966220-4	1995	The polymer used in this study was Polymin Water-Free and its complexation with Hg(II), Cd(II), Pb(II), Co(II) and Ni(II) was successfully modelled.	Polymers	4-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-110
7880828-2	1995	In 1 mM GSH, the constitutive (COX-1) and the mitogen inducible (COX-2) isoforms metabolized arachidonate to 12-hydroxyheptadecatrienoic acid (12-HHT) (88% and 78% of total products, respectively).	Glutathione	8-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-70
7880828-2	1995	In 1 mM GSH, the constitutive (COX-1) and the mitogen inducible (COX-2) isoforms metabolized arachidonate to 12-hydroxyheptadecatrienoic acid (12-HHT) (88% and 78% of total products, respectively).	Arachidonic Acid	93-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-70
7880828-2	1995	In 1 mM GSH, the constitutive (COX-1) and the mitogen inducible (COX-2) isoforms metabolized arachidonate to 12-hydroxyheptadecatrienoic acid (12-HHT) (88% and 78% of total products, respectively).	12-hydroxyheptadecatrienoic acid	109-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-70
7880828-2	1995	In 1 mM GSH, the constitutive (COX-1) and the mitogen inducible (COX-2) isoforms metabolized arachidonate to 12-hydroxyheptadecatrienoic acid (12-HHT) (88% and 78% of total products, respectively).	12-hydroxy-5,8,10-heptadecatrienoic acid	143-149	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-70
7880828-3	1995	Prostanoid formation was consequently reduced to only 12% (COX-1) and 19% (COX-2) of the total metabolites.	Prostaglandins	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
7864817-4	1995	We have characterized the kinetic mechanisms of the interactions of purified recombinant human cyclooxygenase-1 and -2 (hCox-1, hCox-2) with the selective Cox-2 inhibitor N-(2-cyclohexyloxy-4-nitrophenyl)methanesulphonamide (NS-398) and some classical non-selective NSAIDs.	n-(2-cyclohexyloxy-4-nitrophenyl)methanesulphonamide	171-223	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	128-134
7864817-4	1995	We have characterized the kinetic mechanisms of the interactions of purified recombinant human cyclooxygenase-1 and -2 (hCox-1, hCox-2) with the selective Cox-2 inhibitor N-(2-cyclohexyloxy-4-nitrophenyl)methanesulphonamide (NS-398) and some classical non-selective NSAIDs.	n-(2-cyclohexyloxy-4-nitrophenyl)methanesulphonamide	171-223	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-134
7864817-4	1995	We have characterized the kinetic mechanisms of the interactions of purified recombinant human cyclooxygenase-1 and -2 (hCox-1, hCox-2) with the selective Cox-2 inhibitor N-(2-cyclohexyloxy-4-nitrophenyl)methanesulphonamide (NS-398) and some classical non-selective NSAIDs.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	225-231	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	128-134
7864817-5	1995	NS-398, flurbiprofen, meclofenamic acid and indomethacin are time-dependent, irreversible inhibitors of hCox-2.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	0-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-110
7864817-5	1995	NS-398, flurbiprofen, meclofenamic acid and indomethacin are time-dependent, irreversible inhibitors of hCox-2.	Flurbiprofen	8-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-110
7864817-5	1995	NS-398, flurbiprofen, meclofenamic acid and indomethacin are time-dependent, irreversible inhibitors of hCox-2.	Meclofenamic Acid	22-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-110
7864817-5	1995	NS-398, flurbiprofen, meclofenamic acid and indomethacin are time-dependent, irreversible inhibitors of hCox-2.	Indomethacin	44-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-110
7864817-10	1995	The high degree of selectivity of NS-398 towards Cox-2 results therefore from the difference in the nature of the time-dependency of inhibition of the two isoforms.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	34-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-54
18966220-4	1995	The polymer used in this study was Polymin Water-Free and its complexation with Hg(II), Cd(II), Pb(II), Co(II) and Ni(II) was successfully modelled.	Water	43-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-110
7610990-5	1995	Commercially available NSAIDs like indomethacin inhibit both COX-1 and COX-2 suggesting the hypothesis that toxicities associated with NSAID therapy are due to inhibition of the non-regulated or constitutive form of COX (COX-1) in normal tissues, whereas therapeutic benefit derives from inhibition of the inducible enzyme, COX-2, at the site of inflammation.	Indomethacin	35-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-76
7832763-5	1995	of 1500 nmol of O2/nmol of enzyme, whereas hCOX-2 had a specific activity of 12.2 mumol of O2/mg with a Km of 8.7 microM for arachidonate and a Vmax.	Oxygen	91-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-49
7832763-5	1995	of 1500 nmol of O2/nmol of enzyme, whereas hCOX-2 had a specific activity of 12.2 mumol of O2/mg with a Km of 8.7 microM for arachidonate and a Vmax.	Arachidonic Acid	125-137	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-49
7832763-7	1995	Indomethacin inhibited both hCOX-1 and hCOX-2, whereas NS-398 and Dup-697 selectively inhibited hCOX-2.	Indomethacin	0-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-45
7832763-8	1995	Both NS-398 and Dup-697 exhibited time-dependent inactivation of hCOX-2, as did indomethacin on both enzymes.	Nitrogen	5-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-71
7832763-9	1995	The competitive inhibitor of hCOX-1, mefenamic acid, also displayed competitive inhibition of hCOX-2.	Mefenamic Acid	37-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-100
7610990-5	1995	Commercially available NSAIDs like indomethacin inhibit both COX-1 and COX-2 suggesting the hypothesis that toxicities associated with NSAID therapy are due to inhibition of the non-regulated or constitutive form of COX (COX-1) in normal tissues, whereas therapeutic benefit derives from inhibition of the inducible enzyme, COX-2, at the site of inflammation.	Indomethacin	35-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	324-329
7892511-8	1994	The close parallel between the kinetics of COX-2 mRNA and protein expression and PGE2 accumulation in the medium, as well as the constitutive, unregulated nature of the COX-1 isoform, indicates that cytokine-driven PGE2 formation in WISH cells may be mediated by de novo expression of the novel COX-2 enzyme.	Dinoprostone	215-219	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
7664022-6	1995	Several non steroid anti-inflammatory drugs which have more than 1,000 fold selectivity for COX-2 over COX-1 are in the early stages of drug development.	Steroids	12-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-97
7792388-5	1995	Progesterone (10(-7)-10(-6) M) and dexamethasone (10(-7)-10(-6) M) inhibited basal and interleukin-1 beta-stimulated prostaglandin production, and decreased the numbers of COX-2 positive cells.	Progesterone	0-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	172-177
7792388-5	1995	Progesterone (10(-7)-10(-6) M) and dexamethasone (10(-7)-10(-6) M) inhibited basal and interleukin-1 beta-stimulated prostaglandin production, and decreased the numbers of COX-2 positive cells.	Dexamethasone	35-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	172-177
7792388-7	1995	COX-2 seems to be the main enzyme controlling the synthesis of PGE2 by human decidual cells, and may be negatively regulated by progesterone.	Dinoprostone	63-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
7792388-7	1995	COX-2 seems to be the main enzyme controlling the synthesis of PGE2 by human decidual cells, and may be negatively regulated by progesterone.	Progesterone	128-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
18966206-0	1995	Reversed-phase HPLC determination of Co(II), Ni(II) and Fe(III) as their 2-(2-thiazolylazo)-5-dimethylaminophenol chelates.	ferric sulfate	56-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-43
18966206-0	1995	Reversed-phase HPLC determination of Co(II), Ni(II) and Fe(III) as their 2-(2-thiazolylazo)-5-dimethylaminophenol chelates.	5-dimethylamino-2-(2-thiazolylazo)phenol	73-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-43
18966206-1	1995	The optimum chromatographic separation conditions for Co(II), Ni(II), and Fe(III) chelates with 2-(2-thiazolylazo)-5-dimethylaminophenol (TAM) were investigated.	5-dimethylamino-2-(2-thiazolylazo)phenol	96-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-60
18966206-1	1995	The optimum chromatographic separation conditions for Co(II), Ni(II), and Fe(III) chelates with 2-(2-thiazolylazo)-5-dimethylaminophenol (TAM) were investigated.	tam	138-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-60
7991575-4	1994	In an animal model of acute inflammation (injection of carrageenan into the footpad), edema was produced that was associated with marked accumulation of COX-2 mRNA and thromboxane.	Carrageenan	55-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	153-158
7991575-5	1994	A selective inhibitor of COX-2 (SC-58125) inhibited edema at the inflammatory site and was analgesic but had no effect on PG production in the stomach and did not cause gastric toxicity.	1-((4-methylsulfonyl)phenyl)-3-trifluoromethyl-5-(4-fluorophenyl)pyrazole	32-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-30
7892511-8	1994	The close parallel between the kinetics of COX-2 mRNA and protein expression and PGE2 accumulation in the medium, as well as the constitutive, unregulated nature of the COX-1 isoform, indicates that cytokine-driven PGE2 formation in WISH cells may be mediated by de novo expression of the novel COX-2 enzyme.	Dinoprostone	215-219	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	295-300
7858842-16	1994	The glucocorticosteroid, dexamethasone (1 micro M; 30 min prior to cytokines) completely suppressed the cytokine-induced expression of COX-2 protein and activity in both primary cells and A549 cells.6.	glucocorticosteroid	4-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-140
7979387-5	1994	The Km values of arachidonic acid for hCox-2 and ovine Cox-1 are 0.9 and 2.7 microM, respectively.	Arachidonic Acid	17-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-44
7979387-6	1994	Six other C-18 and C-20 fatty acids containing at least one 1,4-cis,cis-pentadiene moiety were also identified as substrates for hCox-2.	Fatty Acids	24-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-135
7979387-6	1994	Six other C-18 and C-20 fatty acids containing at least one 1,4-cis,cis-pentadiene moiety were also identified as substrates for hCox-2.	-cis,cis-pentadiene	63-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-135
7979387-8	1994	hCox-2 binds heme such that maximal activity is observed at a stoichiometry of 1.0 heme per enzyme subunit.	Heme	13-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
7979387-8	1994	hCox-2 binds heme such that maximal activity is observed at a stoichiometry of 1.0 heme per enzyme subunit.	Heme	83-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
7979387-9	1994	The apparent molecular mass of hCox-2, determined by gel filtration chromatography in the presence of 2.0% beta-octylglucoside, is consistent with a dimeric structure.	octyl-beta-D-glucoside	107-126	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-37
7957953-0	1994	A 1H NMR NOE study on Co(II) stellacyanin: some clues about the structure of the metal site.	Hydrogen	2-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-28
7957953-0	1994	A 1H NMR NOE study on Co(II) stellacyanin: some clues about the structure of the metal site.	noe	9-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-28
7957953-0	1994	A 1H NMR NOE study on Co(II) stellacyanin: some clues about the structure of the metal site.	Metals	81-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-28
7957953-1	1994	The 1H NMR spectrum of Co(II) stellacyanin is reported, in which four signals not previously observed have been detected.	Hydrogen	4-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-29
7966148-0	1994	Selective cyclooxygenase inhibitors: novel 1,2-diarylcyclopentenes are potent and orally active COX-2 inhibitors.	1,2-diarylcyclopentenes	43-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-101
7972034-1	1994	Selective inhibition of the inducible isoform of prostaglandin G/H synthase (cyclooxygenase-2; COX2; EC 1.14.99.1) can be achieved with compounds of the general form of aryl methyl sulfonyls and aryl methyl sulfonamides.	Prostaglandins	49-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-99
7972034-1	1994	Selective inhibition of the inducible isoform of prostaglandin G/H synthase (cyclooxygenase-2; COX2; EC 1.14.99.1) can be achieved with compounds of the general form of aryl methyl sulfonyls and aryl methyl sulfonamides.	aryl methyl sulfonyls	169-190	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-99
7972034-1	1994	Selective inhibition of the inducible isoform of prostaglandin G/H synthase (cyclooxygenase-2; COX2; EC 1.14.99.1) can be achieved with compounds of the general form of aryl methyl sulfonyls and aryl methyl sulfonamides.	aryl methyl sulfonamides	195-219	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-99
7858842-16	1994	The glucocorticosteroid, dexamethasone (1 micro M; 30 min prior to cytokines) completely suppressed the cytokine-induced expression of COX-2 protein and activity in both primary cells and A549 cells.6.	Dexamethasone	25-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-140
7858842-17	1994	In experiments where COX-2 activity was supported by endogenous stores of arachidonic acid,treatment of A549 cells with interleukin-l beta but not tumour necrosis factor a or interferon-gamma alone caused a similar release of PGE 2 to that seen when the cytokines were given in combination.	Arachidonic Acid	74-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-26
7858842-17	1994	In experiments where COX-2 activity was supported by endogenous stores of arachidonic acid,treatment of A549 cells with interleukin-l beta but not tumour necrosis factor a or interferon-gamma alone caused a similar release of PGE 2 to that seen when the cytokines were given in combination.	Dinoprostone	226-231	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-26
7858842-18	1994	However, both interleukin-l beta and necrosis factor- alone produced similar increases in COX-2 activity (measured in the presence of exogenous arachidonic acid) as seen when the mixture of interleukin-l beta, tumour necrosis factor- alpha and interferon-gamma were used to stimulate the cells.7.	Arachidonic Acid	144-160	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-95
7858842-19	1994	These findings show that COX-2 expression correlates with the exaggerated release of prostaglandins from cytokine-activated human pulmonary epithelial cells and that the induction of the enzyme is suppressed by a glucocorticosteroid.	Prostaglandins	85-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-30
7858842-19	1994	These findings show that COX-2 expression correlates with the exaggerated release of prostaglandins from cytokine-activated human pulmonary epithelial cells and that the induction of the enzyme is suppressed by a glucocorticosteroid.	glucocorticosteroid	213-232	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-30
7980626-1	1994	Cyclooxygenase (COX), a key enzyme in the formation of prostanoids, is known to exist in two isoforms: an inducible enzyme (COX 2) and a constitutive from (COX 1).	Prostaglandins	55-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	124-129
7620513-2	1994	Prostacyclin formation by endothelial cells in atherosclerosis and diabetes is reviewed and the synthesis of prostacyclin by cyclooxygenase 1 and 2 (COX-1 and COX-2) is discussed.	Epoprostenol	109-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	159-164
7980626-3	1994	In this study, we report on a novel selective inhibitor of COX 2, CGP 28238 (6-(2,4-difluorophenoxy)-5-methyl-sulfonylamino-1-indanon e).	cgp	66-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-64
7980626-3	1994	In this study, we report on a novel selective inhibitor of COX 2, CGP 28238 (6-(2,4-difluorophenoxy)-5-methyl-sulfonylamino-1-indanon e).	flosulide	77-135	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-64
7980626-10	1994	Thus, on the basis of our findings, CGP 28238 is a novel, highly potent and selective inhibitor of COX 2 and may be a lead compound for a new generation of potent anti-inflammatory drugs with an improved side-effect profile.	cgp	36-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-104
8163473-5	1994	We have studied the effect of interleukin-1 alpha (IL-1 alpha), a proinflammatory cytokine that facilitates its actions in part by inducing the synthesis of prostanoids, on the expression of Cox-2 in a human cell line (ECV304) and demonstrated that IL-1 alpha induces a sustained increase in the expression of the Cox-2 mRNA as well as the functional enzyme.	Prostaglandins	157-168	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	191-196
7996812-8	1994	Exposure of HPMC to cytokines or PMo-S.epiCM resulted in the time dependent increase in the levels of both Cox-1 and Cox-2 mRNA as assessed by RT/PCR analysis with the greatest increase being seen for Cox-2.	hydroxypropylmethylcellulose-lactose matrix	12-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-122
7996812-8	1994	Exposure of HPMC to cytokines or PMo-S.epiCM resulted in the time dependent increase in the levels of both Cox-1 and Cox-2 mRNA as assessed by RT/PCR analysis with the greatest increase being seen for Cox-2.	hydroxypropylmethylcellulose-lactose matrix	12-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	201-206
7996812-8	1994	Exposure of HPMC to cytokines or PMo-S.epiCM resulted in the time dependent increase in the levels of both Cox-1 and Cox-2 mRNA as assessed by RT/PCR analysis with the greatest increase being seen for Cox-2.	pmo-s	33-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-122
7996812-8	1994	Exposure of HPMC to cytokines or PMo-S.epiCM resulted in the time dependent increase in the levels of both Cox-1 and Cox-2 mRNA as assessed by RT/PCR analysis with the greatest increase being seen for Cox-2.	pmo-s	33-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	201-206
7954922-0	1994	Synthesis of a novel bis(2,4"-bithiazole) derivative as a Co(II)-activated DNA cleaving agent.	bis(2,4"-bithiazole)	21-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
18966075-1	1994	Cyanex-272 forms a blue-colored complex with Co(II) in the organic phase.	Cyanex 272	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-51
7945196-1	1994	Cyclo-oxygenase (Cox), a rate-limiting enzyme in the synthesis of prostanoids, is encoded by two genes, Cox-1 and Cox-2, which are differentially expressed and regulated.	Prostaglandins	66-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-119
7942324-5	1994	In order to get information about the cyclooxygenase (COX-2) which is inducible in human PMNL by inflammatory mediators via de novo protein biosynthesis, we activated the cells with LPS for 18 h. A 77 1726 and indomethacin had no influence on the enzyme activity of the newly induced COX-2.	Indomethacin	210-222	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-59
8157637-6	1994	Metal coordination by the mutant proteins was evaluated by atomic absorption spectroscopy, Co(II) electronic spectroscopy, and 113Cd NMR spectroscopy.	Metals	0-5	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-97
8038702-5	1994	In support of this hypothesis, expression of the inducible COX-2 enzyme is selectively blocked by the potent anti-inflammatory drug dexamethasone.	Dexamethasone	132-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-64
8038703-3	1994	However, within the context of the inflammatory response, phospholipase A2 as well as cyclooxygenase-2 (COX-2) are induced, resulting in an exacerbated production of prostaglandins.	Prostaglandins	166-180	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
8038703-4	1994	The antiinflammatory steroids will reduce inflammation-induced prostaglandin synthesis by inhibiting the expression of these two key enzymes, PLA2 and COX-2.	Steroids	21-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-156
8038703-4	1994	The antiinflammatory steroids will reduce inflammation-induced prostaglandin synthesis by inhibiting the expression of these two key enzymes, PLA2 and COX-2.	Prostaglandins	63-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-156
8257435-0	1993	A comparison of Zn(II) and Co(II) in the kinetics of inactivation of aminoacylase by 1,10-phenanthroline and reconstitution of the apoenzyme.	1,10-phenanthroline	85-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-33
8132748-6	1994	De novo synthesis of Cox-2 polypeptide was enhanced by IL-1 beta or PMA, and dramatically suppressed by dexamethasone (dex).	Dexamethasone	104-117	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-26
8132748-6	1994	De novo synthesis of Cox-2 polypeptide was enhanced by IL-1 beta or PMA, and dramatically suppressed by dexamethasone (dex).	Dexamethasone	104-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-26
8132748-10	1994	dex markedly suppressed the induction of Cox-2 mRNA.	Dexamethasone	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-46
8292034-6	1994	These data point to the importance of Cox-2 in the increased prostaglandin synthesis associated with labor.	Prostaglandins	61-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-43
8257696-12	1993	Recovery of PGI2 biosynthesis in untreated cells exposed to serum following the inactivation of COX occurred within 12 h, while the recovery of COX activity in lipid-enriched cells did not return to levels observed in untreated cells even after up to 48 h, suggesting that the induction of COX-2 (inducible form of cyclooxygenase) synthesis by growth factors or cytokines is impaired.	Epoprostenol	12-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	290-295
8257696-13	1993	Indeed, cholesterol enrichment attenuated IL-1 beta-, PDGF-, and TNF alpha-induced PGI2 synthesis relative to controls and was consistent with the results of in vitro labeling experiments demonstrating that cholesterol enrichment reduced the incorporation of [35S]methionine into immunoprecipitable COX-1 and COX-2 following induction by PDGF.	Cholesterol	8-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	309-314
8257696-13	1993	Indeed, cholesterol enrichment attenuated IL-1 beta-, PDGF-, and TNF alpha-induced PGI2 synthesis relative to controls and was consistent with the results of in vitro labeling experiments demonstrating that cholesterol enrichment reduced the incorporation of [35S]methionine into immunoprecipitable COX-1 and COX-2 following induction by PDGF.	Cholesterol	207-218	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	309-314
8257696-14	1993	Cholesterol enrichment also reduced the induction of COX-2 mRNA steady-state levels following exposure to PDGF.	Cholesterol	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-58
8257696-15	1993	Taken together, these data demonstrate that reduced eicosanoid synthesis in smooth muscle-derived foam cells is due, in part, to impaired transcription of mRNA for COX-1 and COX-2 as well as fatty acid remodeling in membrane phospholipids.	Eicosanoids	52-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	174-179
8257696-16	1993	These findings support the hypothesis that cholesterol enrichment alters posttranscriptional processing of COX-1 expression, as well as altering COX-2 gene expression.	Cholesterol	43-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-150
7956977-3	1994	The affinity of both metal binding sites for Co(II) is also altered.	Metals	21-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-51
8257435-2	1993	Although the native Zn(II)-containing and the Co(II)-reconstituted enzymes have closely similar Michaelis constants and maximal velocities, the kinetics for both the inactivation by OP and the reconstitution of the apoenzyme with the metal ions differs considerably.	Zinc	20-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-52
8257435-2	1993	Although the native Zn(II)-containing and the Co(II)-reconstituted enzymes have closely similar Michaelis constants and maximal velocities, the kinetics for both the inactivation by OP and the reconstitution of the apoenzyme with the metal ions differs considerably.	Metals	234-239	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-52
8257435-6	1993	Both the native and the Co(II)-reconstituted enzymes are inhibited by excess of Zn(II), but not by Co(II).	Zinc	80-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
8257435-6	1993	Both the native and the Co(II)-reconstituted enzymes are inhibited by excess of Zn(II), but not by Co(II).	Zinc	80-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-30
8492290-0	1993	Polarographic and potentiometric investigation of Co(II) complexes with 5-hydroxytryptophan.	5-Hydroxytryptophan	72-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-56
8226870-7	1993	Both immunoprecipitated Cox-1 and Cox-2 possessed cyclooxygenase activity that was inhibited by flurbiprofen.	Flurbiprofen	96-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-39
8501465-0	1993	Binding of the ferric uptake regulation repressor protein (Fur) to Mn(II), Fe(II), Co(II), and Cu(II) ions as co-repressors: electronic absorption, equilibrium, and 57Fe Mossbauer studies.	Ferric enterobactin ion	15-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
8501465-0	1993	Binding of the ferric uptake regulation repressor protein (Fur) to Mn(II), Fe(II), Co(II), and Cu(II) ions as co-repressors: electronic absorption, equilibrium, and 57Fe Mossbauer studies.	fur	59-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
8501465-3	1993	From the equilibrium studies Kd values of 55, 85, 36, and 10 microM were obtained for the Fur complex with Fe(II), Mn(II), Co(II), and Cu(II), respectively.	fur	90-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-128
8501465-6	1993	Electronic absorption spectra of the Co(II) Fur complex gave evidence of a distorted tetrahedral Co(II) site bound to sulfur.	fur	44-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-42
8501465-6	1993	Electronic absorption spectra of the Co(II) Fur complex gave evidence of a distorted tetrahedral Co(II) site bound to sulfur.	fur	44-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
8501465-6	1993	Electronic absorption spectra of the Co(II) Fur complex gave evidence of a distorted tetrahedral Co(II) site bound to sulfur.	Sulfur	118-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-42
8501465-6	1993	Electronic absorption spectra of the Co(II) Fur complex gave evidence of a distorted tetrahedral Co(II) site bound to sulfur.	Sulfur	118-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
8318649-0	1993	Generation of free radicals from model lipid hydroperoxides and H2O2 by Co(II) in the presence of cysteinyl and histidyl chelators.	Free Radicals	14-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-78
8318649-0	1993	Generation of free radicals from model lipid hydroperoxides and H2O2 by Co(II) in the presence of cysteinyl and histidyl chelators.	Lipid Peroxides	39-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-78
8318649-0	1993	Generation of free radicals from model lipid hydroperoxides and H2O2 by Co(II) in the presence of cysteinyl and histidyl chelators.	Hydrogen Peroxide	64-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-78
8318649-0	1993	Generation of free radicals from model lipid hydroperoxides and H2O2 by Co(II) in the presence of cysteinyl and histidyl chelators.	lysyl-cysteinyl-cysteinyl-arginyl-cysteinyl-lysine	98-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-78
8318649-1	1993	Electron spin resonance spin trapping was utilized to investigate the generation of free radicals from cumene hydroperoxide (cumene-OOH), tert-butyl hydroperoxide (tert-butyl-OOH), and H2O2 at pH 7.2 by Co(II) in the presence of cysteinyl and histidyl chelating agents.	Free Radicals	84-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	203-209
8318649-1	1993	Electron spin resonance spin trapping was utilized to investigate the generation of free radicals from cumene hydroperoxide (cumene-OOH), tert-butyl hydroperoxide (tert-butyl-OOH), and H2O2 at pH 7.2 by Co(II) in the presence of cysteinyl and histidyl chelating agents.	tert-Butylhydroperoxide	138-162	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	203-209
8318649-3	1993	Incubation of Co(II) with cumene-OOH or tert-butyl-OOH did not generate any detectable amounts of free radicals.	cumene	26-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-20
8318649-3	1993	Incubation of Co(II) with cumene-OOH or tert-butyl-OOH did not generate any detectable amounts of free radicals.	OOH	33-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-20
8318649-3	1993	Incubation of Co(II) with cumene-OOH or tert-butyl-OOH did not generate any detectable amounts of free radicals.	tert-butyl-ooh	40-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-20
8318649-4	1993	However, in the presence of glutathione, cysteine, penicillamine, or N-acetylcysteine, Co(II) generated cumene-OOH-derived carbon-centered radicals, cumene alkoxyl radicals, and hydroxyl (.OH) radicals.	Glutathione	28-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-93
8318649-4	1993	However, in the presence of glutathione, cysteine, penicillamine, or N-acetylcysteine, Co(II) generated cumene-OOH-derived carbon-centered radicals, cumene alkoxyl radicals, and hydroxyl (.OH) radicals.	Cysteine	41-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-93
8318649-4	1993	However, in the presence of glutathione, cysteine, penicillamine, or N-acetylcysteine, Co(II) generated cumene-OOH-derived carbon-centered radicals, cumene alkoxyl radicals, and hydroxyl (.OH) radicals.	Penicillamine	51-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-93
8318649-4	1993	However, in the presence of glutathione, cysteine, penicillamine, or N-acetylcysteine, Co(II) generated cumene-OOH-derived carbon-centered radicals, cumene alkoxyl radicals, and hydroxyl (.OH) radicals.	Acetylcysteine	69-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-93
8318649-4	1993	However, in the presence of glutathione, cysteine, penicillamine, or N-acetylcysteine, Co(II) generated cumene-OOH-derived carbon-centered radicals, cumene alkoxyl radicals, and hydroxyl (.OH) radicals.	cumene	104-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-93
8318649-4	1993	However, in the presence of glutathione, cysteine, penicillamine, or N-acetylcysteine, Co(II) generated cumene-OOH-derived carbon-centered radicals, cumene alkoxyl radicals, and hydroxyl (.OH) radicals.	OOH	111-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-93
8318649-4	1993	However, in the presence of glutathione, cysteine, penicillamine, or N-acetylcysteine, Co(II) generated cumene-OOH-derived carbon-centered radicals, cumene alkoxyl radicals, and hydroxyl (.OH) radicals.	cumene alkoxyl radicals	149-172	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-93
8318649-4	1993	However, in the presence of glutathione, cysteine, penicillamine, or N-acetylcysteine, Co(II) generated cumene-OOH-derived carbon-centered radicals, cumene alkoxyl radicals, and hydroxyl (.OH) radicals.	hydroxyl (.oh) radicals	178-201	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-93
8318649-9	1993	Incubation of Co(II) with cumene-OOH ort-butyl-OOH in the presence of the histidyl oligopeptide Gly-Gly-His also generated lipid hydroperoxide-derived free radicals, with the yield being comparable to that obtained using thiols.	cumene	26-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-20
8318649-9	1993	Incubation of Co(II) with cumene-OOH ort-butyl-OOH in the presence of the histidyl oligopeptide Gly-Gly-His also generated lipid hydroperoxide-derived free radicals, with the yield being comparable to that obtained using thiols.	OOH	33-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-20
8318649-9	1993	Incubation of Co(II) with cumene-OOH ort-butyl-OOH in the presence of the histidyl oligopeptide Gly-Gly-His also generated lipid hydroperoxide-derived free radicals, with the yield being comparable to that obtained using thiols.	-butyl-ooh	40-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-20
8318649-9	1993	Incubation of Co(II) with cumene-OOH ort-butyl-OOH in the presence of the histidyl oligopeptide Gly-Gly-His also generated lipid hydroperoxide-derived free radicals, with the yield being comparable to that obtained using thiols.	diglycyl-histidine	96-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-20
8318649-9	1993	Incubation of Co(II) with cumene-OOH ort-butyl-OOH in the presence of the histidyl oligopeptide Gly-Gly-His also generated lipid hydroperoxide-derived free radicals, with the yield being comparable to that obtained using thiols.	Lipid Peroxides	123-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-20
8318649-9	1993	Incubation of Co(II) with cumene-OOH ort-butyl-OOH in the presence of the histidyl oligopeptide Gly-Gly-His also generated lipid hydroperoxide-derived free radicals, with the yield being comparable to that obtained using thiols.	Sulfhydryl Compounds	221-227	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-20
8318649-11	1993	Incubation of Co(II) with H2)2 produced only a small amount of .OH radicals.	h2)2	26-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-20
8318649-11	1993	Incubation of Co(II) with H2)2 produced only a small amount of .OH radicals.	.oh radicals	63-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-20
8450416-4	1993	The hydrogen discharge is favored by the basic centers of the molecule in Co(II)/ammonia-buffered media.	Hydrogen	4-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-80
8450416-4	1993	The hydrogen discharge is favored by the basic centers of the molecule in Co(II)/ammonia-buffered media.	Ammonia	81-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-80
8226870-3	1993	Cyclooxygenase activity of HUVEC challenged with interleukin 1 alpha or a phorbol ester increased in parallel with the mass of a protein doublet analyzed by Western blot using antibodies directed against the Cox-2 peptide; a monoclonal antibody directed against Cox-1 showed a small change in protein mass.	Phorbol Esters	74-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	208-213
8226870-4	1993	A 35S-labeled protein doublet with a molecular mass of approximately 70,000 daltons was immunoprecipitated with the anti-Cox-2 antiserum in L-[35S] methionine-labeled cells stimulated with interleukin 1 alpha.	l-[35s] methionine	140-158	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-126
8371984-3	1993	We carried out X-ray diffraction analyses of the interactions of the two transition metal ions Co(II) and Cu(II) and an alkaline earth metal ion Ba(II), with DNA of different conformations.	Metals	84-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-101
8371984-4	1993	In crystals, Co(II) ion binds exclusively at the N7 position of guanine bases by direct coordination.	Guanine	64-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-19
8371984-8	1993	Model building of Co(II) binding to guanine N7 in B-DNA indicates that the coordinated waters in the axial positions would have a van der Waals clash with the neighboring base on the 5" side.	guanine n7	36-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-24
8371984-8	1993	Model building of Co(II) binding to guanine N7 in B-DNA indicates that the coordinated waters in the axial positions would have a van der Waals clash with the neighboring base on the 5" side.	Water	87-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-24
8492290-1	1993	The formation of the complexes between Co(II) and 5-hydroxytryptophan has been studied by means of polarographic and potentiometric methods.	5-Hydroxytryptophan	50-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-45
24198081-1	1993	The oxidation of elemental sulphur in the catalytic presence of selected metal ions [Cr(III), Ce(III), Cu(II), Hg(II), Ni(II), Co(II), Mo(VI), Cd(II), Zn(II), Ti(IV), and V(V)], and hydrocarbons (benzene, gasoline, and kerosene) was studied in an alkaline medium buffered by marble powder.	elemental sulphur	17-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	127-133
8492290-2	1993	The real stability constants of mono and bis-chelato complexes of Co(II) with 5-hydroxytryptophan, obtained by polarographic method, in Britton-Robinson buffer were found to be, log beta 1 = 4.98 and log beta 2 = 8.45.	mono and bis-chelato	32-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-72
24198081-3	1993	The oxidation process was inhibited in the presence of other ions, and the inhibitive effect was in the following order: Co(II) < Mo(VI) < Cd(II) < Zn(II) < Ti(IV) < V(V).	Cadmium	145-147	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-127
24198081-3	1993	The oxidation process was inhibited in the presence of other ions, and the inhibitive effect was in the following order: Co(II) < Mo(VI) < Cd(II) < Zn(II) < Ti(IV) < V(V).	Zinc	157-159	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-127
8492290-2	1993	The real stability constants of mono and bis-chelato complexes of Co(II) with 5-hydroxytryptophan, obtained by polarographic method, in Britton-Robinson buffer were found to be, log beta 1 = 4.98 and log beta 2 = 8.45.	5-Hydroxytryptophan	78-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-72
8144313-9	1993	The finding that acemetacin is equipotent to indomethacin on leucocyte cyclo-oxygenase (inducible enzyme, COX-2) but less active on the gastric mucosa (COX-1) is consistent with an effective analgesic and anti-inflammatory activity of acemetacin coupled with better gastric tolerance than that to indomethacin.	acemetacin	17-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-111
1359966-5	1992	Other divalent metal ions [Zn(II), Co(II), Mn(II), Cu(II) and Ni(II)] also reduced the fluorescence intensity of the human enzyme by 12-30% when added in stoichiometric amounts.	Metals	15-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-41
1359966-6	1992	The binding of Co(II) at pH 7.2 was also found to affect its 1H-NMR spectrum and this effect was reversed by lowering the pH to 6.1.	Hydrogen	61-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-21
18965533-0	1992	Extraction of Fe(III), Cu(II), Co(II), Ni(II) and Pb(II) with thenoyltrifluoroacetone using the ternary solvent system water/ethanol/methylisobutylketone.	Thenoyltrifluoroacetone	62-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-37
18965533-1	1992	Single-phase solutions (1.72 x 10(-2)M in TTA) of water/ethanol/MIBK, when added to an excess of water, break down into two immiscible liquid layers and TTA complexes of Fe(III), Co(II), Ni(II), Cu(II) and PB(II) are extracted into the organic layer.	Water	50-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	179-185
18965533-1	1992	Single-phase solutions (1.72 x 10(-2)M in TTA) of water/ethanol/MIBK, when added to an excess of water, break down into two immiscible liquid layers and TTA complexes of Fe(III), Co(II), Ni(II), Cu(II) and PB(II) are extracted into the organic layer.	Ethanol	56-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	179-185
18965391-8	1992	Potential interferents, such as Ni(II), Co(II), Zn(II) and Fe(III) could, at a Sn level of 10 microg/l., be tolerated at an excess of 1000 times without impairing the assay, while a 100-1000-fold excess of Cu(II) decreased the signal by 10-15%.	cu(ii)	206-212	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-46
18965533-1	1992	Single-phase solutions (1.72 x 10(-2)M in TTA) of water/ethanol/MIBK, when added to an excess of water, break down into two immiscible liquid layers and TTA complexes of Fe(III), Co(II), Ni(II), Cu(II) and PB(II) are extracted into the organic layer.	1-(carboxymethylthio)tetradecane	153-156	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	179-185
1416035-3	1992	For such sensors, potentiometric oxygen response is attributed to a mixed potential originating from the underlying platinum electrode surface as well as a change in redox potential of the Co(II)-tetren-doped film as the complex binds oxygen reversibly.	Oxygen	33-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	189-195
1416035-3	1992	For such sensors, potentiometric oxygen response is attributed to a mixed potential originating from the underlying platinum electrode surface as well as a change in redox potential of the Co(II)-tetren-doped film as the complex binds oxygen reversibly.	Oxygen	235-241	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	189-195
1416035-4	1992	The response due to the platinum surface is prolonged by the presence of the Co(II)-tetren/PVC film.	Platinum	24-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-83
1327111-1	1992	A binuclear cobalt derivative of arthropod hemocyanin (Hc) has been prepared by the reaction of apo-Hc with Co(II) in the presence of thiocyanate.	Cobalt	12-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-114
1327111-1	1992	A binuclear cobalt derivative of arthropod hemocyanin (Hc) has been prepared by the reaction of apo-Hc with Co(II) in the presence of thiocyanate.	arthropod hemocyanin	33-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-114
1327111-3	1992	The specifically bound Co(II) constitutes a binuclear metal center that exhibits optical and CD spectra typical in their absorption maxima and extinction coefficients of Co(II) complexes with near-tetrahedral geometry.	Cadmium	93-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-29
1327111-3	1992	The specifically bound Co(II) constitutes a binuclear metal center that exhibits optical and CD spectra typical in their absorption maxima and extinction coefficients of Co(II) complexes with near-tetrahedral geometry.	Cadmium	93-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	170-176
1327111-4	1992	The EPR spectrum of the binuclear Co(II) derivative contains a resonance at g approximately 13, which is characteristic of integer spin systems and indicates coupled metal ions; the excess Co(II) bound to crude products exhibits an EPR signal at g approximately 4.	Metals	166-171	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-40
1327111-6	1992	The intensity of the optical absorption in the visible region due to Co(II) increases with increasing stoichiometry of specifically bound metal [up to 2 Co(II) per protein monomer], but the intensity of the Co(II) EPR signal increases only during the formation of a mononuclear derivative.	Metals	138-143	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-75
1327111-8	1992	The binuclear cobalt derivative cannot be reconstituted to native Hc with Cu(I), indicating the stable loading of Co(II) in the active site.	Cobalt	14-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-120
1380156-9	1992	Cox-2 mRNA was preferentially induced by phorbol 12-myristate 13-acetate and lipopolysaccharide in human endothelial cells and monocytes.	Tetradecanoylphorbol Acetate	41-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
1496001-1	1992	A general method is described for substitution of Mn(II) and Co(II) into the diiron sites of hemerythrin and myohemerythrin.	diiron	77-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-67
1631889-11	1992	Regarding direct genotoxic mechanisms, Co(II) induces the formation of reactive oxygen species when combined with hydrogen peroxide in cell-free systems.	Reactive Oxygen Species	71-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-45
1631889-11	1992	Regarding direct genotoxic mechanisms, Co(II) induces the formation of reactive oxygen species when combined with hydrogen peroxide in cell-free systems.	Hydrogen Peroxide	114-131	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-45
1402876-1	1992	Complexes of CuII, NiII, CoII, ZnII, FeIII, CrIII, CdII, and MnII with the natural product 5-hydroxy-7,4"-dimethoxyflavone have been synthesized and the probable structures of these complexes have been proposed on the basis of elemental analyses, molecular weight determination, magnetic moments, and electronic and IR spectral data.	apigenin dimethylether	91-122	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-29
1316186-10	1992	An experiment using 17O-enriched water revealed that the Co(II)-ethylenediamine complex caused the DMPO to react with solvent water to form the DMPO/.OH adduct.	Water	33-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-63
1370470-0	1992	Reaction of Co(II)bleomycin with dioxygen.	Oxygen	33-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-17
1370470-1	1992	The reaction of Co(II)bleomycin with dioxygen has been investigated.	Oxygen	37-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-21
1370470-2	1992	Dioxygen binds to the Co(II) complex within the time of mixing according to electron spin resonance and uv-visible spectroscopy and dioxygen analysis.	Oxygen	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-28
1370470-2	1992	Dioxygen binds to the Co(II) complex within the time of mixing according to electron spin resonance and uv-visible spectroscopy and dioxygen analysis.	Oxygen	132-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-28
1370470-10	1992	In contrast, hydrogen peroxide is readily detected during the reaction of Co(II)Blm with O2.	Hydrogen Peroxide	13-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
1370470-10	1992	In contrast, hydrogen peroxide is readily detected during the reaction of Co(II)Blm with O2.	Oxygen	89-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
1736988-6	1992	In this study, using rapid-scannig stopped-flow (RSSF) UV-visible spectroscopic studies, we demonstrate that a transient chemical intermediate is formed during the phenol-induced conversion of Co(II)-substituted hexamer from the T-state to the R-state.	Phenol	164-170	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	193-198
1316186-1	1992	The electron paramagnetic resonance (EPR) spin trapping technique was used to study the generation of oxygen free radicals from the reaction of hydrogen peroxide with various Co(II) complexes in pH 7.4 phosphate buffer.	Oxygen	102-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	175-181
1316186-1	1992	The electron paramagnetic resonance (EPR) spin trapping technique was used to study the generation of oxygen free radicals from the reaction of hydrogen peroxide with various Co(II) complexes in pH 7.4 phosphate buffer.	Hydrogen Peroxide	144-161	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	175-181
1316186-1	1992	The electron paramagnetic resonance (EPR) spin trapping technique was used to study the generation of oxygen free radicals from the reaction of hydrogen peroxide with various Co(II) complexes in pH 7.4 phosphate buffer.	Phosphates	202-211	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	175-181
1316186-3	1992	Superoxide radical was generated from the reaction of H2O2 with Co(II), but was inhibited when Co(II) was chelated with adenosine 5"-diphosphate or citrate.	Superoxides	0-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-70
1316186-3	1992	Superoxide radical was generated from the reaction of H2O2 with Co(II), but was inhibited when Co(II) was chelated with adenosine 5"-diphosphate or citrate.	Superoxides	0-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-101
1316186-3	1992	Superoxide radical was generated from the reaction of H2O2 with Co(II), but was inhibited when Co(II) was chelated with adenosine 5"-diphosphate or citrate.	Hydrogen Peroxide	54-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-70
1316186-3	1992	Superoxide radical was generated from the reaction of H2O2 with Co(II), but was inhibited when Co(II) was chelated with adenosine 5"-diphosphate or citrate.	Hydrogen Peroxide	54-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-101
1316186-3	1992	Superoxide radical was generated from the reaction of H2O2 with Co(II), but was inhibited when Co(II) was chelated with adenosine 5"-diphosphate or citrate.	Adenosine Diphosphate	120-144	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-70
1316186-3	1992	Superoxide radical was generated from the reaction of H2O2 with Co(II), but was inhibited when Co(II) was chelated with adenosine 5"-diphosphate or citrate.	Adenosine Diphosphate	120-144	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-101
1316186-3	1992	Superoxide radical was generated from the reaction of H2O2 with Co(II), but was inhibited when Co(II) was chelated with adenosine 5"-diphosphate or citrate.	Citric Acid	148-155	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-70
1316186-3	1992	Superoxide radical was generated from the reaction of H2O2 with Co(II), but was inhibited when Co(II) was chelated with adenosine 5"-diphosphate or citrate.	Citric Acid	148-155	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-101
1316186-5	1992	The EDTA complex also prevented detectable free-radical formation when H2O2 was added, but visible absorbance data indicated oxidation of the Co(II) to Co(III) in this case.	Edetic Acid	4-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	142-148
1316186-6	1992	The amount of DMPO/.OOH adduct detected by EPR was greatly enhanced when H2O2 reacted with the nitrilotriacetate complex relative to Co(II) alone, and in addition, concurrent formation of the DMPO/.OH adduct due to slow oxidation of Co(II) was observed.	5,5-dimethyl-1-pyrroline-1-oxide	14-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	133-139
1316186-6	1992	The amount of DMPO/.OOH adduct detected by EPR was greatly enhanced when H2O2 reacted with the nitrilotriacetate complex relative to Co(II) alone, and in addition, concurrent formation of the DMPO/.OH adduct due to slow oxidation of Co(II) was observed.	5,5-dimethyl-1-pyrroline-1-oxide	14-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	233-239
1316186-10	1992	An experiment using 17O-enriched water revealed that the Co(II)-ethylenediamine complex caused the DMPO to react with solvent water to form the DMPO/.OH adduct.	ethylenediamine	64-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-63
1316186-6	1992	The amount of DMPO/.OOH adduct detected by EPR was greatly enhanced when H2O2 reacted with the nitrilotriacetate complex relative to Co(II) alone, and in addition, concurrent formation of the DMPO/.OH adduct due to slow oxidation of Co(II) was observed.	OOH	20-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	133-139
1316186-6	1992	The amount of DMPO/.OOH adduct detected by EPR was greatly enhanced when H2O2 reacted with the nitrilotriacetate complex relative to Co(II) alone, and in addition, concurrent formation of the DMPO/.OH adduct due to slow oxidation of Co(II) was observed.	OOH	20-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	233-239
1316186-6	1992	The amount of DMPO/.OOH adduct detected by EPR was greatly enhanced when H2O2 reacted with the nitrilotriacetate complex relative to Co(II) alone, and in addition, concurrent formation of the DMPO/.OH adduct due to slow oxidation of Co(II) was observed.	Hydrogen Peroxide	73-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	133-139
1316186-10	1992	An experiment using 17O-enriched water revealed that the Co(II)-ethylenediamine complex caused the DMPO to react with solvent water to form the DMPO/.OH adduct.	5,5-dimethyl-1-pyrroline-1-oxide	99-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-63
1316186-6	1992	The amount of DMPO/.OOH adduct detected by EPR was greatly enhanced when H2O2 reacted with the nitrilotriacetate complex relative to Co(II) alone, and in addition, concurrent formation of the DMPO/.OH adduct due to slow oxidation of Co(II) was observed.	Hydrogen Peroxide	73-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	233-239
1316186-10	1992	An experiment using 17O-enriched water revealed that the Co(II)-ethylenediamine complex caused the DMPO to react with solvent water to form the DMPO/.OH adduct.	Water	126-131	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-63
1316186-10	1992	An experiment using 17O-enriched water revealed that the Co(II)-ethylenediamine complex caused the DMPO to react with solvent water to form the DMPO/.OH adduct.	5,5-dimethyl-1-pyrroline-1-oxide	144-148	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-63
1316186-6	1992	The amount of DMPO/.OOH adduct detected by EPR was greatly enhanced when H2O2 reacted with the nitrilotriacetate complex relative to Co(II) alone, and in addition, concurrent formation of the DMPO/.OH adduct due to slow oxidation of Co(II) was observed.	Nitrilotriacetic Acid	95-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	133-139
1316186-6	1992	The amount of DMPO/.OOH adduct detected by EPR was greatly enhanced when H2O2 reacted with the nitrilotriacetate complex relative to Co(II) alone, and in addition, concurrent formation of the DMPO/.OH adduct due to slow oxidation of Co(II) was observed.	Nitrilotriacetic Acid	95-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	233-239
1676967-6	1991	All three isozymes were rapidly activated (13-40-fold) by incubation with Fe(II) salts (concentration of iron at half-maximal activation = 6-14 microM), and were inhibited by other divalent metal ions, e.g. Zn(II), Co(II) and Ni(II).	ammonium ferrous sulfate	74-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	215-221
1316186-6	1992	The amount of DMPO/.OOH adduct detected by EPR was greatly enhanced when H2O2 reacted with the nitrilotriacetate complex relative to Co(II) alone, and in addition, concurrent formation of the DMPO/.OH adduct due to slow oxidation of Co(II) was observed.	5,5-dimethyl-1-pyrroline-1-oxide	192-196	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	133-139
1316186-6	1992	The amount of DMPO/.OOH adduct detected by EPR was greatly enhanced when H2O2 reacted with the nitrilotriacetate complex relative to Co(II) alone, and in addition, concurrent formation of the DMPO/.OH adduct due to slow oxidation of Co(II) was observed.	5,5-dimethyl-1-pyrroline-1-oxide	192-196	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	233-239
1316186-8	1992	The deferoxamine nitroxide radical was exclusively formed when H2O2 was added to the Co(II) complex of this ligand, most probably in a site-specific manner.	deferoxamine nitroxide radical	4-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-91
1316186-8	1992	The deferoxamine nitroxide radical was exclusively formed when H2O2 was added to the Co(II) complex of this ligand, most probably in a site-specific manner.	Hydrogen Peroxide	63-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-91
1316186-9	1992	In the presence of ethylenediamine, Co(II) bound molecular O2 and directly oxidized DMPO to its DMPO/.OH adduct without first forming free superoxide, hydroxyl radical, or hydrogen peroxide.	ethylenediamine	19-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-42
1316186-9	1992	In the presence of ethylenediamine, Co(II) bound molecular O2 and directly oxidized DMPO to its DMPO/.OH adduct without first forming free superoxide, hydroxyl radical, or hydrogen peroxide.	Oxygen	59-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-42
1316186-9	1992	In the presence of ethylenediamine, Co(II) bound molecular O2 and directly oxidized DMPO to its DMPO/.OH adduct without first forming free superoxide, hydroxyl radical, or hydrogen peroxide.	5,5-dimethyl-1-pyrroline-1-oxide	84-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-42
1316186-9	1992	In the presence of ethylenediamine, Co(II) bound molecular O2 and directly oxidized DMPO to its DMPO/.OH adduct without first forming free superoxide, hydroxyl radical, or hydrogen peroxide.	5,5-dimethyl-1-pyrroline-1-oxide	96-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-42
1316186-9	1992	In the presence of ethylenediamine, Co(II) bound molecular O2 and directly oxidized DMPO to its DMPO/.OH adduct without first forming free superoxide, hydroxyl radical, or hydrogen peroxide.	Superoxides	139-149	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-42
1316186-9	1992	In the presence of ethylenediamine, Co(II) bound molecular O2 and directly oxidized DMPO to its DMPO/.OH adduct without first forming free superoxide, hydroxyl radical, or hydrogen peroxide.	Hydroxyl Radical	151-167	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-42
1316186-9	1992	In the presence of ethylenediamine, Co(II) bound molecular O2 and directly oxidized DMPO to its DMPO/.OH adduct without first forming free superoxide, hydroxyl radical, or hydrogen peroxide.	Hydrogen Peroxide	172-189	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-42
1316186-10	1992	An experiment using 17O-enriched water revealed that the Co(II)-ethylenediamine complex caused the DMPO to react with solvent water to form the DMPO/.OH adduct.	17o	20-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-63
1346260-8	1992	The divergence times of both the Amerind and Nadene branches of the COII-tRNA(Lys) deletion lineage were intermediate between the Amerind and Nadene specific lineages, raising the possibility of a third source of mtDNA in American Indians.	nadene	45-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-72
1933852-4	1991	In the present work, we have investigated the ability of Ni(II) and Co(II) ions in the presence of H2O2 to cause chemical changes in DNA bases in chromatin extracted from cultured cells of human origin.	Hydrogen Peroxide	99-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-74
1933852-9	1991	Partial inhibition of product formation indicated a possible "site-specific" formation of hydroxyl radical by unchelated Ni(II) and Co(II) ions bound to chromatin.	Hydroxyl Radical	90-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-138
1933852-10	1991	Although treatment of chromatin for 1 h with Co(II)/H2O2 caused formation of significant amounts of products, treatment with Ni(II)/H2O2 required incubation times of more than 5 h and an increase in Ni(II) concentration before increases in product amounts above background levels became detectable.	Nickel(2+)	199-205	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-51
1933852-14	1991	Chelation of Ni(II) and Co(II) ions with EDTA almost completely inhibited product formation.	Edetic Acid	41-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-30
1933852-16	1991	DNA damage in chromatin caused by Ni(II) and Co(II) ions in the presence of H2O2 may contribute to the established genotoxicity and carcinogenicity of these metal ions.	Hydrogen Peroxide	76-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-51
1933852-16	1991	DNA damage in chromatin caused by Ni(II) and Co(II) ions in the presence of H2O2 may contribute to the established genotoxicity and carcinogenicity of these metal ions.	Metals	157-162	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-51
1676967-6	1991	All three isozymes were rapidly activated (13-40-fold) by incubation with Fe(II) salts (concentration of iron at half-maximal activation = 6-14 microM), and were inhibited by other divalent metal ions, e.g. Zn(II), Co(II) and Ni(II).	Iron	105-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	215-221
1676967-6	1991	All three isozymes were rapidly activated (13-40-fold) by incubation with Fe(II) salts (concentration of iron at half-maximal activation = 6-14 microM), and were inhibited by other divalent metal ions, e.g. Zn(II), Co(II) and Ni(II).	Metals	190-195	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	215-221
1676967-6	1991	All three isozymes were rapidly activated (13-40-fold) by incubation with Fe(II) salts (concentration of iron at half-maximal activation = 6-14 microM), and were inhibited by other divalent metal ions, e.g. Zn(II), Co(II) and Ni(II).	Zinc	207-213	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	215-221
1645541-1	1991	Exposure of albumin to sulfite in the presence of Co(II) or peroxidase/H2O2 caused site-specific fragmentation, which was not due to cleavage of methionyl nor tryptophanyl peptide bonds.	Sulfites	23-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-56
2065051-11	1991	The HCO3- and pyridine-2-thiolate ions form Co(II)-R6 adducts that are proposed to possess pentacoordinate Co(II) geometries.	Bicarbonates	4-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-50
2065051-11	1991	The HCO3- and pyridine-2-thiolate ions form Co(II)-R6 adducts that are proposed to possess pentacoordinate Co(II) geometries.	Bicarbonates	4-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-113
2065051-11	1991	The HCO3- and pyridine-2-thiolate ions form Co(II)-R6 adducts that are proposed to possess pentacoordinate Co(II) geometries.	pyridine-2-thiolate	14-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-50
2065051-11	1991	The HCO3- and pyridine-2-thiolate ions form Co(II)-R6 adducts that are proposed to possess pentacoordinate Co(II) geometries.	pyridine-2-thiolate	14-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-113
1645541-2	1991	The reaction of GlyPro with sulfite in the presence of Co(II) or peroxidase/H2O2 led to Gly liberation, suggesting the oxidative cleavage of protein at Pro residues.	glycylproline	16-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-61
1645541-2	1991	The reaction of GlyPro with sulfite in the presence of Co(II) or peroxidase/H2O2 led to Gly liberation, suggesting the oxidative cleavage of protein at Pro residues.	Sulfites	28-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-61
1645541-2	1991	The reaction of GlyPro with sulfite in the presence of Co(II) or peroxidase/H2O2 led to Gly liberation, suggesting the oxidative cleavage of protein at Pro residues.	Glycine	16-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-61
1645541-3	1991	Sulfite plus Co(II) induced bityrosine production, Trp loss and a new Trp-derived fluorescence.	dityrosine	28-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
1645541-3	1991	Sulfite plus Co(II) induced bityrosine production, Trp loss and a new Trp-derived fluorescence.	Tryptophan	51-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
1645541-3	1991	Sulfite plus Co(II) induced bityrosine production, Trp loss and a new Trp-derived fluorescence.	Tryptophan	70-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
1645541-4	1991	ESR-spin trapping method provided evidence for the formation of sulfate radical (SO4.-) during Co(II)-catalyzed autoxidation of sulfite.	sulfate radical	64-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-101
1645541-4	1991	ESR-spin trapping method provided evidence for the formation of sulfate radical (SO4.-) during Co(II)-catalyzed autoxidation of sulfite.	sulfuric acid	81-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-101
1645541-4	1991	ESR-spin trapping method provided evidence for the formation of sulfate radical (SO4.-) during Co(II)-catalyzed autoxidation of sulfite.	Sulfites	128-135	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-101
1848978-1	1991	Hydralazine caused site-specific DNA damage in the presence of Cu(II), Co(II), Fe(III), or peroxidase/H2O2.	Hydralazine	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-77
1848978-2	1991	The order of inducing effect of metal ions on hydralazine-dependent DNA damage [Cu(II) greater than Co(II) greater than Fe(III)] was related to that of accelerating effect on the O2 consumption rate of hydralazine autoxidation.	Metals	32-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-106
1848978-2	1991	The order of inducing effect of metal ions on hydralazine-dependent DNA damage [Cu(II) greater than Co(II) greater than Fe(III)] was related to that of accelerating effect on the O2 consumption rate of hydralazine autoxidation.	Hydralazine	46-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-106
1848978-2	1991	The order of inducing effect of metal ions on hydralazine-dependent DNA damage [Cu(II) greater than Co(II) greater than Fe(III)] was related to that of accelerating effect on the O2 consumption rate of hydralazine autoxidation.	ferric sulfate	120-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-106
1848978-2	1991	The order of inducing effect of metal ions on hydralazine-dependent DNA damage [Cu(II) greater than Co(II) greater than Fe(III)] was related to that of accelerating effect on the O2 consumption rate of hydralazine autoxidation.	Superoxides	179-181	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-106
1848978-2	1991	The order of inducing effect of metal ions on hydralazine-dependent DNA damage [Cu(II) greater than Co(II) greater than Fe(III)] was related to that of accelerating effect on the O2 consumption rate of hydralazine autoxidation.	Hydralazine	202-213	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-106
1846358-4	1991	The order of inducing effect on hydrazine-dependent DNA damage (Mn(III) greater than Mn(II) approximately Cu(II) much greater than Co(II) approximately Fe(III)) was related to that of the accelerating effect on the O2 consumption rate of hydrazine autoxidation.	fe(iii))	152-160	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-136
18965142-2	1991	The determination of Fe(III) and Co(II) based on displacement of Fe(III) and Co(II) from their EGTA complexes by PAR, was used as a model system.	ferric sulfate	21-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-83
18965142-2	1991	The determination of Fe(III) and Co(II) based on displacement of Fe(III) and Co(II) from their EGTA complexes by PAR, was used as a model system.	ferric sulfate	65-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-39
18965142-2	1991	The determination of Fe(III) and Co(II) based on displacement of Fe(III) and Co(II) from their EGTA complexes by PAR, was used as a model system.	Egtazic Acid	95-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-39
18965142-2	1991	The determination of Fe(III) and Co(II) based on displacement of Fe(III) and Co(II) from their EGTA complexes by PAR, was used as a model system.	Egtazic Acid	95-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-83
1846358-3	1991	Hydrazine caused DNA damage in the presence of Mn(III), Mn(II), Cu(II), Co(II), and Fe(III).	hydrazine	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
1846358-4	1991	The order of inducing effect on hydrazine-dependent DNA damage (Mn(III) greater than Mn(II) approximately Cu(II) much greater than Co(II) approximately Fe(III)) was related to that of the accelerating effect on the O2 consumption rate of hydrazine autoxidation.	hydrazine	32-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-136
1846358-4	1991	The order of inducing effect on hydrazine-dependent DNA damage (Mn(III) greater than Mn(II) approximately Cu(II) much greater than Co(II) approximately Fe(III)) was related to that of the accelerating effect on the O2 consumption rate of hydrazine autoxidation.	Oxygen	215-217	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-136
1846358-4	1991	The order of inducing effect on hydrazine-dependent DNA damage (Mn(III) greater than Mn(II) approximately Cu(II) much greater than Co(II) approximately Fe(III)) was related to that of the accelerating effect on the O2 consumption rate of hydrazine autoxidation.	hydrazine	238-247	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-136
2176890-15	1990	The divalent cation specificity has been investigated by studies on the symmetric chromomycin-d(A2G2C2T2) complex in the presence of diamagnetic Mg(II), Zn(II), and Cd(II) cations and paramagnetic Ni(II) and Co(II) cations.	chromomycin-d	82-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	208-214
2247162-3	1990	Here we describe an XAS study of divalent cobalt (Co(II)) complexes sorbed on three different solids, gamma-Al2O3, rutile (TiO2) and kaolinite (Al2Si2O5(OH)4).	Cobalt	42-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-56
2271687-7	1990	The characteristic absorption spectrum of the Co(II)-substituted protein fully supports the model of a tetrahedral binding site comprised of two Cys and two His ligands.	Cysteine	145-148	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-52
2271687-7	1990	The characteristic absorption spectrum of the Co(II)-substituted protein fully supports the model of a tetrahedral binding site comprised of two Cys and two His ligands.	Histidine	157-160	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-52
2247162-3	1990	Here we describe an XAS study of divalent cobalt (Co(II)) complexes sorbed on three different solids, gamma-Al2O3, rutile (TiO2) and kaolinite (Al2Si2O5(OH)4).	gamma-al2o3	102-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-56
2247162-3	1990	Here we describe an XAS study of divalent cobalt (Co(II)) complexes sorbed on three different solids, gamma-Al2O3, rutile (TiO2) and kaolinite (Al2Si2O5(OH)4).	titanium dioxide	123-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-56
2247162-3	1990	Here we describe an XAS study of divalent cobalt (Co(II)) complexes sorbed on three different solids, gamma-Al2O3, rutile (TiO2) and kaolinite (Al2Si2O5(OH)4).	Kaolin	133-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-56
2247162-3	1990	Here we describe an XAS study of divalent cobalt (Co(II)) complexes sorbed on three different solids, gamma-Al2O3, rutile (TiO2) and kaolinite (Al2Si2O5(OH)4).	al2si2o5	144-152	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-56
1976385-8	1990	Ni(II), Cu(II) and Co(II) accelerated chemical reactions from dopachrome but inhibited its decarboxylation.	dopachrome	62-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-25
18965065-6	1990	The flux of Zn(II) was about 40 times that of Cu(II) and 100 times that of Co(II) when their concentrations in the sample were equal.	Zinc	12-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-81
2118529-3	1990	In the absence of coordinating anions, the coordination spheres of the Co(II) ions in the proinsulin and insulin R6 hexamers comprise identical pseudotetrahedral arrangements of 3 histidine residues and 1 hydroxide ion.	Histidine	180-189	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-77
2118529-4	1990	At alkaline pH, the visible absorption spectrum of the phenol-induced R6 Co(II) center is strikingly similar to the distinctive spectrum of the alkaline form of Co(II)-carbonic anhydrase.	Phenol	55-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-79
1966712-7	1990	The substitution of the endogenous zinc with Co(II) Cu(II) produces a holoenzyme which is slightly activated in the case of Co(II), whereas, in the case of Cu(II) only 65% of the initial activity is recovered.	cu(ii)	52-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-51
2118529-4	1990	At alkaline pH, the visible absorption spectrum of the phenol-induced R6 Co(II) center is strikingly similar to the distinctive spectrum of the alkaline form of Co(II)-carbonic anhydrase.	Phenol	55-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	161-167
2118529-5	1990	Exogenous ligands may coordinate to the Co(II) ions of the R6 proinsulin and insulin hexamers via replacement of the hydroxide ion, forming pseudotetrahedral adducts possessing characteristic spectra.	hydroxide ion	117-126	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-46
2380707-2	1990	For [(CN)2CoIIITPPS]-, reduction occurs stepwise to the CoII, CoI, and finally to the phlorin anion.	phlorin anion	86-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-14
18964957-1	1990	The chemiluminescence of the reaction of tartaric acid with hydrogen peroxide in the presence of Co(II) in alkaline buffer media has been examined.	tartaric acid	41-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-103
18964957-1	1990	The chemiluminescence of the reaction of tartaric acid with hydrogen peroxide in the presence of Co(II) in alkaline buffer media has been examined.	Hydrogen Peroxide	60-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-103
18964957-4	1990	Foreign ions, such as Fe(II), Cr(III) and Mn(II), interfere when present in more than 10-fold ratio to Co(II), but several ions can be tolerated when present in higher ratios to Co(II).	ammonium ferrous sulfate	22-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-109
18964957-4	1990	Foreign ions, such as Fe(II), Cr(III) and Mn(II), interfere when present in more than 10-fold ratio to Co(II), but several ions can be tolerated when present in higher ratios to Co(II).	ammonium ferrous sulfate	22-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	178-184
18964957-4	1990	Foreign ions, such as Fe(II), Cr(III) and Mn(II), interfere when present in more than 10-fold ratio to Co(II), but several ions can be tolerated when present in higher ratios to Co(II).	tris(1,10-phenanthroline)chromium(III) chloride	30-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-109
18964957-4	1990	Foreign ions, such as Fe(II), Cr(III) and Mn(II), interfere when present in more than 10-fold ratio to Co(II), but several ions can be tolerated when present in higher ratios to Co(II).	Manganese(2+)	42-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-109
2158815-4	1990	When Mn(II) is present in combination with Zn(II), Ni(II), or Co(II), Mn(II) binds predominantly at the site defined by ligands from the protein, oxalate, and the gamma-phosphate of ATP.	Manganese(2+)	70-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-68
2158815-4	1990	When Mn(II) is present in combination with Zn(II), Ni(II), or Co(II), Mn(II) binds predominantly at the site defined by ligands from the protein, oxalate, and the gamma-phosphate of ATP.	Oxalates	146-153	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-68
2158815-4	1990	When Mn(II) is present in combination with Zn(II), Ni(II), or Co(II), Mn(II) binds predominantly at the site defined by ligands from the protein, oxalate, and the gamma-phosphate of ATP.	Phosphates	169-178	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-68
2158815-4	1990	When Mn(II) is present in combination with Zn(II), Ni(II), or Co(II), Mn(II) binds predominantly at the site defined by ligands from the protein, oxalate, and the gamma-phosphate of ATP.	Adenosine Triphosphate	182-185	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-68
1966712-7	1990	The substitution of the endogenous zinc with Co(II) Cu(II) produces a holoenzyme which is slightly activated in the case of Co(II), whereas, in the case of Cu(II) only 65% of the initial activity is recovered.	cu(ii)	52-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	124-130
33819782-8	2021	Co(II) Co(III) Co(II) redox reaction cycle was constructed due to the different redox potential of Co(II)/Co(III), HSO5-/SO4 -, and HSO5-/SO5 -.	Cobalt(2+)	0-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-21
33941107-0	2021	COXIBs and 2,5-dimethylcelecoxib counteract the hyperactivated Wnt/beta-catenin pathway and COX-2/PGE2/EP4 signaling in glioblastoma cells.	2,5-dimethylcelecoxib	11-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-97
33941107-15	2021	COXIBs and 2,5-DMC did not influence MGMT methylation status, but inhibited COX-2/PGE2/EP4 pathway.	2,5-dimethylcelecoxib	11-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-81
33773784-7	2021	Mechanistically, based on phospholipidomics analysis, we found that calcium-independent phospholipase A2 (iPLA2) played a key role with regard to the OOV-mediated arachidonic acid (AA)/COX-2/PG pathway, whereas secretory phospholipase A2 (sPLA2) and cytoplasmic phospholipase A2 (cPLA2) are responsible for the OEO-mediated AA/COX-2/PG pathway.	Arachidonic Acid	163-179	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	185-190
33773784-7	2021	Mechanistically, based on phospholipidomics analysis, we found that calcium-independent phospholipase A2 (iPLA2) played a key role with regard to the OOV-mediated arachidonic acid (AA)/COX-2/PG pathway, whereas secretory phospholipase A2 (sPLA2) and cytoplasmic phospholipase A2 (cPLA2) are responsible for the OEO-mediated AA/COX-2/PG pathway.	Arachidonic Acid	163-179	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	327-332
33941107-15	2021	COXIBs and 2,5-DMC did not influence MGMT methylation status, but inhibited COX-2/PGE2/EP4 pathway.	Dinoprostone	82-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-81
33813964-5	2021	Compounds 3c, 5c, 5h and Celecoxib were subjected to in vitro COX-1 and COX-2 inhibition assay, showed selectivity index 45.04, 102.04, 131.58 and 185.18, respectively.	5C	14-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
33813964-5	2021	Compounds 3c, 5c, 5h and Celecoxib were subjected to in vitro COX-1 and COX-2 inhibition assay, showed selectivity index 45.04, 102.04, 131.58 and 185.18, respectively.	5h	18-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
33813964-5	2021	Compounds 3c, 5c, 5h and Celecoxib were subjected to in vitro COX-1 and COX-2 inhibition assay, showed selectivity index 45.04, 102.04, 131.58 and 185.18, respectively.	Celecoxib	25-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
33813964-6	2021	The computational finding supported those of in vitro, where the pyrazolylpyrazolines interacted with the COX-2 enzyme in a similar orientation to that of Celecoxib, while chlacones were found to exhibit similar orientation to that of Diclofenac.	pyrazolylpyrazolines	65-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-111
33813964-6	2021	The computational finding supported those of in vitro, where the pyrazolylpyrazolines interacted with the COX-2 enzyme in a similar orientation to that of Celecoxib, while chlacones were found to exhibit similar orientation to that of Diclofenac.	Celecoxib	155-164	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-111
33813964-6	2021	The computational finding supported those of in vitro, where the pyrazolylpyrazolines interacted with the COX-2 enzyme in a similar orientation to that of Celecoxib, while chlacones were found to exhibit similar orientation to that of Diclofenac.	Diclofenac	235-245	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-111
33819782-8	2021	Co(II) Co(III) Co(II) redox reaction cycle was constructed due to the different redox potential of Co(II)/Co(III), HSO5-/SO4 -, and HSO5-/SO5 -.	Cobalt(2+)	0-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-21
33819782-8	2021	Co(II) Co(III) Co(II) redox reaction cycle was constructed due to the different redox potential of Co(II)/Co(III), HSO5-/SO4 -, and HSO5-/SO5 -.	co(iii)	7-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-21
33819782-8	2021	Co(II) Co(III) Co(II) redox reaction cycle was constructed due to the different redox potential of Co(II)/Co(III), HSO5-/SO4 -, and HSO5-/SO5 -.	co(iii)	7-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-21
33819782-8	2021	Co(II) Co(III) Co(II) redox reaction cycle was constructed due to the different redox potential of Co(II)/Co(III), HSO5-/SO4 -, and HSO5-/SO5 -.	co(iii)	106-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-21
33819782-8	2021	Co(II) Co(III) Co(II) redox reaction cycle was constructed due to the different redox potential of Co(II)/Co(III), HSO5-/SO4 -, and HSO5-/SO5 -.	co(iii)	106-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-21
33805849-0	2021	2,6-Bis((benzoyl-R)amino)pyridine (R = H, 4-Me, and 4-NMe2) Derivatives for the Removal of Cu(II), Ni(II), Co(II), and Zn(II) Ions from Aqueous Solutions in Classic Solvent Extraction and a Membrane Extraction.	2,6-bis((benzoyl-r)amino)pyridine	0-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-113
33805849-0	2021	2,6-Bis((benzoyl-R)amino)pyridine (R = H, 4-Me, and 4-NMe2) Derivatives for the Removal of Cu(II), Ni(II), Co(II), and Zn(II) Ions from Aqueous Solutions in Classic Solvent Extraction and a Membrane Extraction.	zn(ii)	119-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-113
33801036-3	2021	Acetates of three divalent first-transition metal cations, Co(II), Cu(II) and Zn(II), were used and several bases were tested, depending on the chosen substrates and reaction conditions, with a view to making the whole process more sustainable while ensuring its scalability.	Acetates	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
33815493-4	2021	On chelation with Co(II) and Ni(II), it behaved as mononegative and neutral tridentate via O, N1, and S donors, respectively, while it showed neutral bidentate mode via O and N1 atoms with Zn(II).	Sulfur	102-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-24
33815493-4	2021	On chelation with Co(II) and Ni(II), it behaved as mononegative and neutral tridentate via O, N1, and S donors, respectively, while it showed neutral bidentate mode via O and N1 atoms with Zn(II).	zn(ii)	189-195	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-24
33815493-7	2021	The XRD pattern of the metal complexes showed that both Co(II) and Ni(II) have amorphous nature, while Zn(II) complex has monoclinic crystallinity with an average size of 9.10 nm.	Metals	23-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-62
33815493-9	2021	The calculated HOMO-LUMO energy gap, DeltaEH-L, of the ligand complexes was 1.96-2.49 eV range where HAAT < Zn(II) < Ni(II) < Co(II).	zn(ii)	108-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-132
17973474-1	2007	The preparation of new CoII-mu-OH-CoII dimers with the binucleating ligands 3,5-bis{bis[(N"-R-ureaylato)-N-ethyl]aminomethyl}-1H-pyrazolate ([H4PRbuam]5-, R=tBu, iPr) is described.	3,5-bis{bis[(n"-r-ureaylato)-n-ethyl]aminomethyl}-1h-pyrazolate	76-139	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-27
33763287-0	2021	Graphene Oxide/Polyvinyl Alcohol/Fe3O4 Nanocomposite: An Efficient Adsorbent for Co(II) Ion Removal.	ferryl iron	33-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-87
33821020-2	2021	The dithiocarbamate acted as bidentate chelating ligands to afford a tetrahedral complexes with Co(II) ion and square planner with other transition metal ions.	Dithiocarbamate	4-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-102
31769666-6	2019	In particular, the central metal atom adopts a high-spin (S = 2) state in 2-Fe, while the cobalt complex 2-Co represents a rare example of a Co(II) species with a coordination number different from six displaying a low-spin to high-spin spin-crossover (SCO) behavior.	Cobalt	90-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	141-147
26335632-12	2015	DHA and EPA supplementation affected HMGECs in vitro and supported anti-inflammatory effects by influencing cytokine levels, decreasing COX-2 expression and increasing the production of RvD1.	Docosahexaenoic Acids	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	136-141
26335632-12	2015	DHA and EPA supplementation affected HMGECs in vitro and supported anti-inflammatory effects by influencing cytokine levels, decreasing COX-2 expression and increasing the production of RvD1.	Eicosapentaenoic Acid	8-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	136-141
33774361-2	2021	In this paper, the intercalation composite material of carbon nitride itanium dioxide (g-C3N4/TiO2) composite material which combined the advantages of the two materials was prepared and its actual effect of removing Co (II) from wastewater was evaluated.	carbon nitride itanium dioxide	55-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	217-224
33774361-2	2021	In this paper, the intercalation composite material of carbon nitride itanium dioxide (g-C3N4/TiO2) composite material which combined the advantages of the two materials was prepared and its actual effect of removing Co (II) from wastewater was evaluated.	titanium dioxide	94-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	217-224
33774361-8	2021	The experimental results proved that g-C3N4/TiO2 composite material had a good adsorption and removal effect on extremely low concentration of Co (II) and was a promising adsorbent for removal radioactive Co (II) from nuclear industrial wastewater.	titanium dioxide	44-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	143-150
33774361-8	2021	The experimental results proved that g-C3N4/TiO2 composite material had a good adsorption and removal effect on extremely low concentration of Co (II) and was a promising adsorbent for removal radioactive Co (II) from nuclear industrial wastewater.	titanium dioxide	44-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	205-212
33809724-5	2021	Inducible inflammatory key enzymatic pathways, as iNOS and COX-2/mPGES-1/PGE2, were upregulated by the cytokine mix while PBMT reverted their levels and activities.	Dinoprostone	73-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-64
33763287-0	2021	Graphene Oxide/Polyvinyl Alcohol/Fe3O4 Nanocomposite: An Efficient Adsorbent for Co(II) Ion Removal.	graphene oxide	0-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-87
33763287-0	2021	Graphene Oxide/Polyvinyl Alcohol/Fe3O4 Nanocomposite: An Efficient Adsorbent for Co(II) Ion Removal.	Polyvinyl Alcohol	15-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-87
33820460-2	2021	Ibuprofen acts as a potential inhibitor for cyclooxygenase enzymes (COX-1 and COX-2).	Ibuprofen	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-83
33237143-7	2020	Vinpocetine significantly decreased the generation of nitric oxide-inducible nitric oxide synthase (iNOS), cyclooxygenase- (COX-) 2 in a dose-dependent manner.	vinpocetine	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-131
33033709-1	2020	In inflammation-associated carcinogenesis, COX-2 is markedly overexpressed, resulting in accumulation of various prostaglandins.	Prostaglandins	113-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
33033709-2	2020	15-deoxy-Delta12,14-prostaglandin J2 (15d-PGJ2) is one of the terminal products of COX-2-catalyzed arachidonic acid catabolism with oncogenic potential.	15-deoxy-delta(12,14)-prostaglandin J2	38-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
33033709-2	2020	15-deoxy-Delta12,14-prostaglandin J2 (15d-PGJ2) is one of the terminal products of COX-2-catalyzed arachidonic acid catabolism with oncogenic potential.	Arachidonic Acid	99-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
27667548-5	2016	Furthermore, baicalein blocked the TNF-alpha-induced expression of NF-kappaB target genes involved in anti-apoptosis (cIAP-1, cIAP-2, FLIP and BCL-2), proliferation (COX-2, cyclin D1 and c-Myc), invasion (MMP-9), angiogenesis (VEGF) and major inflammatory cytokines (IL-8 and MCP1).	baicalein	13-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	166-171
26236964-2	2015	We applied ex situ quick X-ray absorption spectroscopy (QXAS) to determine the time evolution of Co(II) and Co(III) surface loadings and their respective average surface speciation in Mn(III)-rich delta-MnO2 samples at pH 6.5 and loadings of 0.01-0.20 mol Co mol(-1) Mn.	manganese dioxide	203-207	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-103
26236964-3	2015	In this Mn oxide, which contained few unoccupied vacancies but abundant Mn(III) at edge and interlayer sites, Co(II) sorption and oxidation started at the particle edges.	mn oxide	8-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-115
12907132-4	2003	The LPS-enhanced PGE2 synthesis and the expression of cPLA2 and COX-2 mRNAs were inhibited by clarithromycin, azithromycin and dexamethasone in PMNLs and MNLs.	Clarithromycin	94-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-69
12907132-4	2003	The LPS-enhanced PGE2 synthesis and the expression of cPLA2 and COX-2 mRNAs were inhibited by clarithromycin, azithromycin and dexamethasone in PMNLs and MNLs.	Azithromycin	110-122	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-69
12907132-6	2003	Macrolide antibiotics inhibited PGE2 synthesis in human leukocytes by suppressing cPLA2, COX-1, and COX-2 mRNA expression.	macrolide antibiotics	0-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-105
12907132-6	2003	Macrolide antibiotics inhibited PGE2 synthesis in human leukocytes by suppressing cPLA2, COX-1, and COX-2 mRNA expression.	Dinoprostone	32-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-105
12907132-4	2003	The LPS-enhanced PGE2 synthesis and the expression of cPLA2 and COX-2 mRNAs were inhibited by clarithromycin, azithromycin and dexamethasone in PMNLs and MNLs.	Dexamethasone	127-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-69
17973474-1	2007	The preparation of new CoII-mu-OH-CoII dimers with the binucleating ligands 3,5-bis{bis[(N"-R-ureaylato)-N-ethyl]aminomethyl}-1H-pyrazolate ([H4PRbuam]5-, R=tBu, iPr) is described.	3,5-bis{bis[(n"-r-ureaylato)-n-ethyl]aminomethyl}-1h-pyrazolate	76-139	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-38
17973474-1	2007	The preparation of new CoII-mu-OH-CoII dimers with the binucleating ligands 3,5-bis{bis[(N"-R-ureaylato)-N-ethyl]aminomethyl}-1H-pyrazolate ([H4PRbuam]5-, R=tBu, iPr) is described.	tert-Butyl Alcohol	157-160	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-27
17973474-1	2007	The preparation of new CoII-mu-OH-CoII dimers with the binucleating ligands 3,5-bis{bis[(N"-R-ureaylato)-N-ethyl]aminomethyl}-1H-pyrazolate ([H4PRbuam]5-, R=tBu, iPr) is described.	tert-Butyl Alcohol	157-160	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-38
17973474-3	2007	Structural and spectroscopic studies show that there are four hydrogen-bond (H-bond) donors near the CoII-micro-OH-CoII moiety; however, they are too far away to be form intramolecular H-bonds with the bridging hydroxo ligand.	Hydrogen	62-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-105
17973474-3	2007	Structural and spectroscopic studies show that there are four hydrogen-bond (H-bond) donors near the CoII-micro-OH-CoII moiety; however, they are too far away to be form intramolecular H-bonds with the bridging hydroxo ligand.	Hydrogen	62-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-119
17973474-4	2007	Treating [CoII2H4PRbuam(micro-OH)]2- with acetonitrile led to the formation of bridging acetamidato complexes, [CoII2H4PRbuam(micro-1,3-OC(NH)CH3)]2-; in addition, these CoII-micro-OH-CoII dimers hydrolyze ethyl acetate to form CoII complexes with bridging acetato ligands.	coii2h4prbuam	10-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-116
17973474-4	2007	Treating [CoII2H4PRbuam(micro-OH)]2- with acetonitrile led to the formation of bridging acetamidato complexes, [CoII2H4PRbuam(micro-1,3-OC(NH)CH3)]2-; in addition, these CoII-micro-OH-CoII dimers hydrolyze ethyl acetate to form CoII complexes with bridging acetato ligands.	coii2h4prbuam	10-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-116
17973474-4	2007	Treating [CoII2H4PRbuam(micro-OH)]2- with acetonitrile led to the formation of bridging acetamidato complexes, [CoII2H4PRbuam(micro-1,3-OC(NH)CH3)]2-; in addition, these CoII-micro-OH-CoII dimers hydrolyze ethyl acetate to form CoII complexes with bridging acetato ligands.	acetonitrile	42-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-14
17973474-4	2007	Treating [CoII2H4PRbuam(micro-OH)]2- with acetonitrile led to the formation of bridging acetamidato complexes, [CoII2H4PRbuam(micro-1,3-OC(NH)CH3)]2-; in addition, these CoII-micro-OH-CoII dimers hydrolyze ethyl acetate to form CoII complexes with bridging acetato ligands.	acetonitrile	42-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-116
17973474-4	2007	Treating [CoII2H4PRbuam(micro-OH)]2- with acetonitrile led to the formation of bridging acetamidato complexes, [CoII2H4PRbuam(micro-1,3-OC(NH)CH3)]2-; in addition, these CoII-micro-OH-CoII dimers hydrolyze ethyl acetate to form CoII complexes with bridging acetato ligands.	acetonitrile	42-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-116
17973474-4	2007	Treating [CoII2H4PRbuam(micro-OH)]2- with acetonitrile led to the formation of bridging acetamidato complexes, [CoII2H4PRbuam(micro-1,3-OC(NH)CH3)]2-; in addition, these CoII-micro-OH-CoII dimers hydrolyze ethyl acetate to form CoII complexes with bridging acetato ligands.	ethyl acetate	206-219	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-14
12512030-1	2003	BACKGROUND &amp; AIMS: The effects of leukotriene (LT) D(4) on intestinal epithelial cells govern events that are involved in cell survival and colon cancer, notably increased expression of cyclooxygenase (COX)-2 and enhanced production of prostaglandin E(2).	Leukotrienes	38-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	190-212
12512030-1	2003	BACKGROUND &amp; AIMS: The effects of leukotriene (LT) D(4) on intestinal epithelial cells govern events that are involved in cell survival and colon cancer, notably increased expression of cyclooxygenase (COX)-2 and enhanced production of prostaglandin E(2).	Prostaglandins E	240-255	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	190-212
17973474-4	2007	Treating [CoII2H4PRbuam(micro-OH)]2- with acetonitrile led to the formation of bridging acetamidato complexes, [CoII2H4PRbuam(micro-1,3-OC(NH)CH3)]2-; in addition, these CoII-micro-OH-CoII dimers hydrolyze ethyl acetate to form CoII complexes with bridging acetato ligands.	ethyl acetate	206-219	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-116
17973474-4	2007	Treating [CoII2H4PRbuam(micro-OH)]2- with acetonitrile led to the formation of bridging acetamidato complexes, [CoII2H4PRbuam(micro-1,3-OC(NH)CH3)]2-; in addition, these CoII-micro-OH-CoII dimers hydrolyze ethyl acetate to form CoII complexes with bridging acetato ligands.	ethyl acetate	206-219	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-116
17973474-7	2007	The tetradentate ligand 3-{bis[(N"-tert-butylureaylato)-N-ethyl]aminomethyl}-5-tert-butyl-1H-pyrazolato ([H2PtBuuam]3-) was also developed and its CoII-OH complex prepared.	3-{bis[(n"-tert-butylureaylato)-n-ethyl]aminomethyl}-5-tert-butyl-1h-pyrazolato	24-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-151
17973474-10	2007	In contrast, K2[CoIIH2PtBuuam(OH)] does react with ethyl acetate to produce KOAc; this enhanced reactivity is attributed to the presence of the K+ ions, which can possibly interact with the CoII-OH unit and ester substrate to assist in hydrolysis.	ethyl acetate	51-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-20
17973474-10	2007	In contrast, K2[CoIIH2PtBuuam(OH)] does react with ethyl acetate to produce KOAc; this enhanced reactivity is attributed to the presence of the K+ ions, which can possibly interact with the CoII-OH unit and ester substrate to assist in hydrolysis.	Potassium Acetate	76-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-20
17973474-10	2007	In contrast, K2[CoIIH2PtBuuam(OH)] does react with ethyl acetate to produce KOAc; this enhanced reactivity is attributed to the presence of the K+ ions, which can possibly interact with the CoII-OH unit and ester substrate to assist in hydrolysis.	Esters	207-212	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-20
34953459-3	2022	The voltammetry showed that the redox couple of Co(II)/Co(III) and Ni(II)/Ni(III) as the mediator catalytically transferred the electrons of NO2-/NO3-; the Ni site had a relatively high transfer coefficient and diffusive current, while the Co site was better in the capacitive removal of the nitrite and nitrate compounds.	co(iii)	55-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-54
10536875-3	1999	Metal complexes of some of these Schiff bases with divalent transition ions such as Zn(II), Cu(II), Co(II) and Ni(II) have also been obtained.	Metals	0-5	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-117
10536875-3	1999	Metal complexes of some of these Schiff bases with divalent transition ions such as Zn(II), Cu(II), Co(II) and Ni(II) have also been obtained.	Schiff Bases	33-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-117
34862103-5	2022	Meanwhile, cobalt doping promotes H2O2 decomposition by accelerated Fe(II)/Fe(III) cycle and Co(II)/Co(III) redox.	Cobalt	11-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-99
34862103-5	2022	Meanwhile, cobalt doping promotes H2O2 decomposition by accelerated Fe(II)/Fe(III) cycle and Co(II)/Co(III) redox.	Hydrogen Peroxide	34-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-99
34862103-5	2022	Meanwhile, cobalt doping promotes H2O2 decomposition by accelerated Fe(II)/Fe(III) cycle and Co(II)/Co(III) redox.	co(iii)	100-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-99
34863568-4	2022	The results from the characterizations of the prepared CoFe2O4 (CoFe2O4-LIBs) show that it possesses higher ratio of Co(II)/Co(III) and Fe(II)/Fe(III), larger surface specific area and more number of acid sites in comparison with pure CoFe2O4.	cobalt ferrite	55-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-123
34863568-4	2022	The results from the characterizations of the prepared CoFe2O4 (CoFe2O4-LIBs) show that it possesses higher ratio of Co(II)/Co(III) and Fe(II)/Fe(III), larger surface specific area and more number of acid sites in comparison with pure CoFe2O4.	cofe2o4-libs	64-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-123
34863568-4	2022	The results from the characterizations of the prepared CoFe2O4 (CoFe2O4-LIBs) show that it possesses higher ratio of Co(II)/Co(III) and Fe(II)/Fe(III), larger surface specific area and more number of acid sites in comparison with pure CoFe2O4.	cobalt ferrite	235-242	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-123
34953459-3	2022	The voltammetry showed that the redox couple of Co(II)/Co(III) and Ni(II)/Ni(III) as the mediator catalytically transferred the electrons of NO2-/NO3-; the Ni site had a relatively high transfer coefficient and diffusive current, while the Co site was better in the capacitive removal of the nitrite and nitrate compounds.	ni(iii)	74-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-54
34953459-3	2022	The voltammetry showed that the redox couple of Co(II)/Co(III) and Ni(II)/Ni(III) as the mediator catalytically transferred the electrons of NO2-/NO3-; the Ni site had a relatively high transfer coefficient and diffusive current, while the Co site was better in the capacitive removal of the nitrite and nitrate compounds.	Nitrogen Dioxide	141-144	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-54
34953459-3	2022	The voltammetry showed that the redox couple of Co(II)/Co(III) and Ni(II)/Ni(III) as the mediator catalytically transferred the electrons of NO2-/NO3-; the Ni site had a relatively high transfer coefficient and diffusive current, while the Co site was better in the capacitive removal of the nitrite and nitrate compounds.	Nitrates	146-150	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-54
34953459-3	2022	The voltammetry showed that the redox couple of Co(II)/Co(III) and Ni(II)/Ni(III) as the mediator catalytically transferred the electrons of NO2-/NO3-; the Ni site had a relatively high transfer coefficient and diffusive current, while the Co site was better in the capacitive removal of the nitrite and nitrate compounds.	Cobalt	240-242	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-54
34953459-3	2022	The voltammetry showed that the redox couple of Co(II)/Co(III) and Ni(II)/Ni(III) as the mediator catalytically transferred the electrons of NO2-/NO3-; the Ni site had a relatively high transfer coefficient and diffusive current, while the Co site was better in the capacitive removal of the nitrite and nitrate compounds.	Nitrites	292-299	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-54
34953459-3	2022	The voltammetry showed that the redox couple of Co(II)/Co(III) and Ni(II)/Ni(III) as the mediator catalytically transferred the electrons of NO2-/NO3-; the Ni site had a relatively high transfer coefficient and diffusive current, while the Co site was better in the capacitive removal of the nitrite and nitrate compounds.	Nitrates	304-311	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-54
34808298-12	2022	It was found that ZJP has a down-regulating effect on inflammatory reaction and could inhibit the relative mRNA and protein expression of JMJD2B/COX-2/VEGF axis and HMGB1/NF-kappaB signaling pathway in vivo and in vitro, including JMJD2B, COX-2, VEGF, VEGFR1, and VEGFR2, which in turn reduced the damage of gastric mucosal cells.	zjp	18-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-150
34774613-3	2022	The coexistence of Co and Ni in various valence states might accelerate the cyclic process of Co(II)/Co(III) and Ni(II)/Ni(III), thereby improving the catalytic activity.	Cobalt	19-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-100
34774613-3	2022	The coexistence of Co and Ni in various valence states might accelerate the cyclic process of Co(II)/Co(III) and Ni(II)/Ni(III), thereby improving the catalytic activity.	co(iii)	101-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-100
34774613-3	2022	The coexistence of Co and Ni in various valence states might accelerate the cyclic process of Co(II)/Co(III) and Ni(II)/Ni(III), thereby improving the catalytic activity.	Nickel(2+)	113-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-100
34774613-3	2022	The coexistence of Co and Ni in various valence states might accelerate the cyclic process of Co(II)/Co(III) and Ni(II)/Ni(III), thereby improving the catalytic activity.	ni(iii)	120-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-100
34808298-12	2022	It was found that ZJP has a down-regulating effect on inflammatory reaction and could inhibit the relative mRNA and protein expression of JMJD2B/COX-2/VEGF axis and HMGB1/NF-kappaB signaling pathway in vivo and in vitro, including JMJD2B, COX-2, VEGF, VEGFR1, and VEGFR2, which in turn reduced the damage of gastric mucosal cells.	zjp	18-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	239-244
34808298-13	2022	CONCLUSIONS: The results suggested that ZJP exerts therapeutic effects on H. pylori-induced CAG by inhibiting the JMJD2B/COX-2/VEGF axis and HMGB1/NF-kappaB signaling pathway.	zjp	40-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-126
34775318-4	2022	The improved catalytic phenol degradation by reactive-oxidative-species (ROS) from PMS was well correlated with the more active Co(II) and Mn(II) species, reactive active oxygen-vacancy and the interfacial engineering effect in the CMO catalyst.	Phenol	23-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	128-134
34743880-7	2022	Further reduction of emission intensity helps national HCEs reach the peak around 2025 in the high scenario at 1063 MtCO2.	hces	55-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-121
34741938-3	2022	The experimental results of the batch tests revealed that in single-metal systems, the removal efficiency of Cu(II), Co(II), Cr(VI) and As(III) could reach 98% at equilibrium.	Metals	68-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-123
34741938-5	2022	For the continuous tests, column filled with chitosan-zero valent iron-based composites, exhibited optimal removal efficiency and achieved average removal values of 98.84%, 88.28%, 95.65% and 87.10% for Cu(II), Co(II), Cr(VI) and As(III) during the whole 30-day operation, respectively.	Iron	66-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	211-217
34741938-8	2022	Moreover, the adsorbed Cu(II), Co(II) and Cr(VI) gradually transferred to the mobile phase when the operational periods were prolonged, while As(III) became more stable.	as(iii)	142-149	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-37
34523500-0	2022	Competitive kinetics of Ni(II)/Co(II) and Cr(VI)/P(V) adsorption and desorption on goethite: A unified thermodynamically based model.	Nickel(2+)	24-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-37
34523500-0	2022	Competitive kinetics of Ni(II)/Co(II) and Cr(VI)/P(V) adsorption and desorption on goethite: A unified thermodynamically based model.	goethite	83-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-37
34523500-2	2022	In this study, the thermodynamic and kinetic adsorption behaviors of Ni(II), Co(II), Cr(VI), and P(V) on goethite under various condition were investigated by batch and stirred-flow experiments, respectively.	goethite	105-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-83
34523500-4	2022	Ni(II) and Co(II) exhibit similar adsorption affinities, while the adsorption of P(V) was stronger and faster than that of Cr(VI).	Penicillin V	81-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-17
34523500-4	2022	Ni(II) and Co(II) exhibit similar adsorption affinities, while the adsorption of P(V) was stronger and faster than that of Cr(VI).	Chromium	123-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-17
34523500-6	2022	The kinetic model was successfully used to predict the binary competitive adsorption of Ni(II)-Co(II) and Cr(VI)-P(V), and especially the overshooting of Cr(VI) induced by P(V).	Nickel(2+)	88-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-101
34523500-6	2022	The kinetic model was successfully used to predict the binary competitive adsorption of Ni(II)-Co(II) and Cr(VI)-P(V), and especially the overshooting of Cr(VI) induced by P(V).	cr(vi)-p	106-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-101
34523500-6	2022	The kinetic model was successfully used to predict the binary competitive adsorption of Ni(II)-Co(II) and Cr(VI)-P(V), and especially the overshooting of Cr(VI) induced by P(V).	Chromium	154-156	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-101
34523500-6	2022	The kinetic model was successfully used to predict the binary competitive adsorption of Ni(II)-Co(II) and Cr(VI)-P(V), and especially the overshooting of Cr(VI) induced by P(V).	Phosphorus	172-173	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-101
34906776-3	2022	Flavocoxid is a mixed extract containing baicalin and catechin showing antioxidant effects and anti-inflammatory activity mainly due to a dual inhibition of inducible cyclooxygenase (COX-2), 5-lipoxygenase (5-LOX) and NLRP3 pathway.	flavocoxid	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	183-188
34893997-1	2022	Derivatives of the cytotoxic cyclooxygenase (COX) inhibitor ((prop-2-ynyl)-2-acetoxybenzoate)dicobalthexacarbonyl (Co-ASS) with a methyl group in the 3, 4, 5, or 6 position of the acetylsalicylic acid (ASS) scaffold were synthesized with the aim to achieve enhanced selectivity for COX-2.	((prop-2-ynyl)-2-acetoxybenzoate)dicobalthexacarbonyl	60-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	282-287
34893997-1	2022	Derivatives of the cytotoxic cyclooxygenase (COX) inhibitor ((prop-2-ynyl)-2-acetoxybenzoate)dicobalthexacarbonyl (Co-ASS) with a methyl group in the 3, 4, 5, or 6 position of the acetylsalicylic acid (ASS) scaffold were synthesized with the aim to achieve enhanced selectivity for COX-2.	co-ass	115-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	282-287
34893997-1	2022	Derivatives of the cytotoxic cyclooxygenase (COX) inhibitor ((prop-2-ynyl)-2-acetoxybenzoate)dicobalthexacarbonyl (Co-ASS) with a methyl group in the 3, 4, 5, or 6 position of the acetylsalicylic acid (ASS) scaffold were synthesized with the aim to achieve enhanced selectivity for COX-2.	Aspirin	180-200	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	282-287
34893997-6	2022	The reduced growth-inhibitory potency in T-24 cells, which express distinctly fewer COX enzymes (COX-1/COX-2 = 50/1) than HT-29 cells (COX-1/COX-2 = 50/50), and the only marginal activity in COX-negative MCF-7 breast cancer cells point to an interference in the arachidonic acid cascade through COX-2 inhibition as part of the mode of action, especially as the cellular uptake was even higher in MCF-7 cells than in T-24 cells.	Arachidonic Acid	262-278	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	295-300
34906776-3	2022	Flavocoxid is a mixed extract containing baicalin and catechin showing antioxidant effects and anti-inflammatory activity mainly due to a dual inhibition of inducible cyclooxygenase (COX-2), 5-lipoxygenase (5-LOX) and NLRP3 pathway.	Catechin	54-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	183-188
34959176-4	2022	A molecular docking study showed that the hybrids8-13(L13-L18) fitted similarly with celecoxib in the COX-2 active site.	Celecoxib	85-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-107
34959176-7	2022	Whereas the P-selectin is a promising target to the design of new anti-inflammatory drugs with antithrombotic properties, a distinct butterfly-like structure of 1,4-diaryl-1,2,3-triazole neolignan-celecoxib hybrids synthesized in this work may be a safer alternative to the traditional COX-2 inhibitors.	Celecoxib	197-206	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	286-291
34906776-6	2022	Flavocoxid increased Nrf2, prompted a marked reduction in malondialdehyde levels and reduced the expression of COX-2 and 5-LOX together with PGE2, and LTB4 levels.	flavocoxid	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	111-116
34959176-5	2022	According to this data, it is possible to infer that extra hydrophobic interactions and the hydrogen interactions with the triazole core may improve the selectivity towards the COX-2 active site.	Hydrogen	92-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	177-182
34959176-5	2022	According to this data, it is possible to infer that extra hydrophobic interactions and the hydrogen interactions with the triazole core may improve the selectivity towards the COX-2 active site.	Triazoles	123-131	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	177-182
34902542-6	2022	Using complementary approaches, we demonstrate that OT-induced COX-2 induction and the concomitant release of PGF2alpha into the media are primarily ERK5-dependent and to a much lesser extent ERK1/2-dependent.	Dinoprost	110-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-68
34818808-4	2022	To address this knowledge gap, pyrene was used as a model compound to investigate the biodegradation of polycyclic aromatic hydrocarbon on montmorillonite mineral saturated with metal ions (Na(I), Ni(II), Co(II), Cu(II) and Fe(III)) by Mycobacteria strain NJS-1.	pyrene	31-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	205-211
34929480-7	2022	Further, POH treatment has decreased the pro-inflammatory serum cytokine levels such as IL-6, IL-12/23, TNF-alpha and IL-1beta and also reduced the expression levels of various inflammatory proteins, COX-2, iNOS, IL-17A, IL-22, NF-kB and STAT3 evidenced by Immunoblotting studies from skin samples.	perillyl alcohol	9-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	200-205
34818808-6	2022	The results show that pyrene biodegradation on montmorillonite was markedly influenced by surface metal ions, with degradation efficiency following the order Fe(III) > Na(I)   Co(II) > Ni(II)   Cu(II).	pyrene	22-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	176-182
34818808-6	2022	The results show that pyrene biodegradation on montmorillonite was markedly influenced by surface metal ions, with degradation efficiency following the order Fe(III) > Na(I)   Co(II) > Ni(II)   Cu(II).	Metals	98-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	176-182
34427852-5	2022	Our results showed that GA significantly attenuated LPS-induced ALI and decreased the production of inflammatory factors, including IL-1beta, MCP-1, COX2, HMGB1, and adhesion molecules, such as E-selectin, VCAM-1, and modulated expression of angiotensin-converting enzyme 2 (ACE2).	Glycyrrhizic Acid	24-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	149-153
34780082-3	2022	The Co(II) centers in the (2)catenane exhibit slow relaxation of their magnetic moment, i.e. single-molecule magnet properties, dominated by quantum tunneling and Raman relaxation processes.	(2)catenane	26-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
34818808-4	2022	To address this knowledge gap, pyrene was used as a model compound to investigate the biodegradation of polycyclic aromatic hydrocarbon on montmorillonite mineral saturated with metal ions (Na(I), Ni(II), Co(II), Cu(II) and Fe(III)) by Mycobacteria strain NJS-1.	Polycyclic Aromatic Hydrocarbons	104-135	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	205-211
34818808-4	2022	To address this knowledge gap, pyrene was used as a model compound to investigate the biodegradation of polycyclic aromatic hydrocarbon on montmorillonite mineral saturated with metal ions (Na(I), Ni(II), Co(II), Cu(II) and Fe(III)) by Mycobacteria strain NJS-1.	Bentonite	139-154	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	205-211
34882407-1	2022	A series of beta-TCBD (1,1,4,4-tetracyano-buta-1,3-diene)-appended porphyrins, M-TCBD (M = 2H, Co(II), Ni(II), Cu(II), and Zn(II)), was synthesized from 2,3-diphenylethynyl-12-nitro-meso-tetraphenylporphyrin, H2-PE2, and characterized by various spectroscopic techniques and electrochemical studies.	beta-tcbd	12-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-101
34882407-1	2022	A series of beta-TCBD (1,1,4,4-tetracyano-buta-1,3-diene)-appended porphyrins, M-TCBD (M = 2H, Co(II), Ni(II), Cu(II), and Zn(II)), was synthesized from 2,3-diphenylethynyl-12-nitro-meso-tetraphenylporphyrin, H2-PE2, and characterized by various spectroscopic techniques and electrochemical studies.	1,1,4,4-tetracyano-buta-1,3-diene	23-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-101
34882407-1	2022	A series of beta-TCBD (1,1,4,4-tetracyano-buta-1,3-diene)-appended porphyrins, M-TCBD (M = 2H, Co(II), Ni(II), Cu(II), and Zn(II)), was synthesized from 2,3-diphenylethynyl-12-nitro-meso-tetraphenylporphyrin, H2-PE2, and characterized by various spectroscopic techniques and electrochemical studies.	Porphyrins	67-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-101
34882407-1	2022	A series of beta-TCBD (1,1,4,4-tetracyano-buta-1,3-diene)-appended porphyrins, M-TCBD (M = 2H, Co(II), Ni(II), Cu(II), and Zn(II)), was synthesized from 2,3-diphenylethynyl-12-nitro-meso-tetraphenylporphyrin, H2-PE2, and characterized by various spectroscopic techniques and electrochemical studies.	m-tcbd	79-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-101
34773856-5	2022	Oxalic acid concentration was a trade-off between the loading of matrix elements and the % sorption of Co(II).	Oxalic Acid	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-109
34736674-0	2022	The synergistic effects of coupling Au nanoparticles with an alkynyl Co(II) phthalocyanine on the detection of prostate specific antigen.	Gold	36-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-75
34918918-1	2022	To investigate the influence of the coordination geometry on the magnetization relaxation dynamics, two geometric isomers of a five-coordinate low-spin Co(II) complex with the general molecular formula (Co(DPPE)2Cl)SnCl3 (DPPE = diphenylphosphinoethane) were synthesized and structurally characterized.	(co(dppe)2cl)sncl3	202-220	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-158
34918918-1	2022	To investigate the influence of the coordination geometry on the magnetization relaxation dynamics, two geometric isomers of a five-coordinate low-spin Co(II) complex with the general molecular formula (Co(DPPE)2Cl)SnCl3 (DPPE = diphenylphosphinoethane) were synthesized and structurally characterized.	dppe	222-226	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-158
34918918-1	2022	To investigate the influence of the coordination geometry on the magnetization relaxation dynamics, two geometric isomers of a five-coordinate low-spin Co(II) complex with the general molecular formula (Co(DPPE)2Cl)SnCl3 (DPPE = diphenylphosphinoethane) were synthesized and structurally characterized.	Ethyldiphenylphosphine	229-252	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-158
34237915-1	2022	Objective: To investigate the effect of associating calcium butyrate with tannin extract, compared to an antimicrobial on the growth performance, incidence of diarrhea, intestinal histology, immune-expression of COX-2 and TNF-alpha of piglets.	CALCIUM BUTYRATE	52-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	212-217
34808482-7	2022	We found that the production of inflammatory factors, PGE2, and COX-2 was significantly elevated in IL-17A-treated mast cells, accompanied by the activation of the iNOS/NO axis and the elevated secretion of ROS.	ros	207-210	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-69
34688374-3	2022	We investigated the efficacy and safety of PD-1 blockade with toripalimab, with or without the COX-2 inhibitor celecoxib, as neoadjuvant treatment for mismatch repair-deficient or microsatellite instability-high, locally advanced, colorectal cancers.	Celecoxib	111-120	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-100
34808482-8	2022	After treatment with allopurinol, the elevated inflammation, activated COX-2/PGE2 and iNOS/NO axis, and oxidative stress were all dramatically alleviated.	Allopurinol	21-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-76
34798265-1	2022	Inflammation is closely linked to the abnormal phospholipid metabolism chain of cyclooxygenase-2/microsomal prostaglandin E2 synthase-1/prostaglandin E2 (COX-2/mPGES-1/PGE2).	Phospholipids	47-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	154-159
34798265-1	2022	Inflammation is closely linked to the abnormal phospholipid metabolism chain of cyclooxygenase-2/microsomal prostaglandin E2 synthase-1/prostaglandin E2 (COX-2/mPGES-1/PGE2).	Dinoprostone	108-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	154-159
34798265-1	2022	Inflammation is closely linked to the abnormal phospholipid metabolism chain of cyclooxygenase-2/microsomal prostaglandin E2 synthase-1/prostaglandin E2 (COX-2/mPGES-1/PGE2).	Dinoprostone	136-152	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	154-159
34798265-1	2022	Inflammation is closely linked to the abnormal phospholipid metabolism chain of cyclooxygenase-2/microsomal prostaglandin E2 synthase-1/prostaglandin E2 (COX-2/mPGES-1/PGE2).	Dinoprostone	168-172	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	154-159
34963412-7	2021	The molecular docking was used to predict the efficiency of binding of the metal complexes with COX- 2.Communicated by Ramaswamy H. Sarma.	Metals	75-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-102
34904615-0	2021	1D alignment of Co(II) metalated porphyrin-napthalimide based self-assembled nanowires for photocatalytic hydrogen evolution.	porphyrin-napthalimide	33-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-22
34904615-0	2021	1D alignment of Co(II) metalated porphyrin-napthalimide based self-assembled nanowires for photocatalytic hydrogen evolution.	Hydrogen	106-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-22
34904615-5	2021	Detailed studies suggest that the Co(II) substituent D-A system (PN2) displayed a well-aligned one-dimensional (1D) nanowire with high electrical conductivity promoting remarkable photocatalytic hydrogen production rate (18 mM g-1 h-1) when compared to that of porphyrin-based derivatives reported until now.	Hydrogen	195-203	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-40
34904615-5	2021	Detailed studies suggest that the Co(II) substituent D-A system (PN2) displayed a well-aligned one-dimensional (1D) nanowire with high electrical conductivity promoting remarkable photocatalytic hydrogen production rate (18 mM g-1 h-1) when compared to that of porphyrin-based derivatives reported until now.	Porphyrins	261-270	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-40
34847327-3	2021	Through an approach that relies on mechanistic insights and systematic examination of ligand and counterion effects, we developed an efficient cobalt-based catalytic system ((P~P)CoX2/Me3Al) (P~P = bisphosphine) to effect the first enantioselective heterodimerization of several types of 1,3-dienes with ethylene.	Cobalt	143-149	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	179-183
34847327-3	2021	Through an approach that relies on mechanistic insights and systematic examination of ligand and counterion effects, we developed an efficient cobalt-based catalytic system ((P~P)CoX2/Me3Al) (P~P = bisphosphine) to effect the first enantioselective heterodimerization of several types of 1,3-dienes with ethylene.	bisphosphine	198-210	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	179-183
34847327-3	2021	Through an approach that relies on mechanistic insights and systematic examination of ligand and counterion effects, we developed an efficient cobalt-based catalytic system ((P~P)CoX2/Me3Al) (P~P = bisphosphine) to effect the first enantioselective heterodimerization of several types of 1,3-dienes with ethylene.	ethylene	304-312	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	179-183
34847327-3	2021	Through an approach that relies on mechanistic insights and systematic examination of ligand and counterion effects, we developed an efficient cobalt-based catalytic system ((P~P)CoX2/Me3Al) (P~P = bisphosphine) to effect the first enantioselective heterodimerization of several types of 1,3-dienes with ethylene.	1,3-dienes	288-298	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	179-183
34419911-5	2021	The synergistic effect between ROS and RCS promoted by the enhanced oxygen vacancies and the efficient redox recycling of FeIII/FeII and CoIII/CoII.	ros	31-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	143-147
34823356-3	2021	In the structure of 1, the bpptz - radical ligand enwraps two Co(II) centers within quasi-TPR geometries, which are further bridged by the tetrazine radical in the trans mode.	bpptz - radical	27-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-68
34823356-3	2021	In the structure of 1, the bpptz - radical ligand enwraps two Co(II) centers within quasi-TPR geometries, which are further bridged by the tetrazine radical in the trans mode.	1,2,3,4-tetrazine	139-148	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-68
34419911-5	2021	The synergistic effect between ROS and RCS promoted by the enhanced oxygen vacancies and the efficient redox recycling of FeIII/FeII and CoIII/CoII.	Oxygen	68-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	143-147
34943044-6	2021	We found, in both RAW 264.7 cells and HaCaT cells, MAEO inhibited LPS-stimulated inflammatory mediators such as nitric oxide (NO) and prostaglandin E2 and proinflammatory cytokines, including IL-1beta and IL-6, due to the suppression of COX-2 and iNOS expression.	maeo	51-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	237-242
34802239-1	2021	The metallo-radical activation of ortho-allylcarbonyl-aryl N-arylsulfonylhydrazones with the paramagnetic cobalt(II) porphyrin catalyst (CoII(TPP)) (TPP = tetraphenylporphyrin) provides an efficient and powerful method for the synthesis of novel 8-membered heterocyclic enol ethers.	metallo-radical	4-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-141
34802239-1	2021	The metallo-radical activation of ortho-allylcarbonyl-aryl N-arylsulfonylhydrazones with the paramagnetic cobalt(II) porphyrin catalyst (CoII(TPP)) (TPP = tetraphenylporphyrin) provides an efficient and powerful method for the synthesis of novel 8-membered heterocyclic enol ethers.	ortho-allylcarbonyl-aryl n-arylsulfonylhydrazones	34-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-141
34802239-1	2021	The metallo-radical activation of ortho-allylcarbonyl-aryl N-arylsulfonylhydrazones with the paramagnetic cobalt(II) porphyrin catalyst (CoII(TPP)) (TPP = tetraphenylporphyrin) provides an efficient and powerful method for the synthesis of novel 8-membered heterocyclic enol ethers.	cobalt(ii) porphyrin	106-126	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-141
34802239-1	2021	The metallo-radical activation of ortho-allylcarbonyl-aryl N-arylsulfonylhydrazones with the paramagnetic cobalt(II) porphyrin catalyst (CoII(TPP)) (TPP = tetraphenylporphyrin) provides an efficient and powerful method for the synthesis of novel 8-membered heterocyclic enol ethers.	tetraphenylporphine sulfonate	149-152	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-141
34802239-1	2021	The metallo-radical activation of ortho-allylcarbonyl-aryl N-arylsulfonylhydrazones with the paramagnetic cobalt(II) porphyrin catalyst (CoII(TPP)) (TPP = tetraphenylporphyrin) provides an efficient and powerful method for the synthesis of novel 8-membered heterocyclic enol ethers.	tetraphenylporphyrin	155-175	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-141
34802239-1	2021	The metallo-radical activation of ortho-allylcarbonyl-aryl N-arylsulfonylhydrazones with the paramagnetic cobalt(II) porphyrin catalyst (CoII(TPP)) (TPP = tetraphenylporphyrin) provides an efficient and powerful method for the synthesis of novel 8-membered heterocyclic enol ethers.	8-membered heterocyclic enol ethers	246-281	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-141
34537445-3	2021	Given this desperate need and inspired by the encouraging results of a phase II trial via concomitant Topo I inhibitor plus COX-2 inhibitor, we designed a series of N-2-(phenylamino) benzamide derivatives as novel anti-glioblastoma agents based on structure modification on 1,5-naphthyridine derivatives (Topo I inhibitors).	n-2-(phenylamino) benzamide	165-192	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	124-129
34537445-4	2021	Notably, the target compounds I-1 (33.61 +- 1.15 muM) and I-8 (45.01 +- 2.37 muM) were confirmed to inhibit COX-2, while a previous reported compound (1,5-naphthyridine derivative) resulted nearly inactive towards COX-2 (IC50 > 150 muM).	1,5-Naphthyridine	151-168	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-113
34842870-5	2021	The Co in this Co(OH)2-x layer presents most of the CoII and a small part of the CoIII, and the interlayer nitrate anion balances the positive charge of the host layer.	co(oh)	15-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-56
34842870-6	2021	The redox function produced by the CoII and CoIII of alpha-Co(OH)2 together with the large layer spacing jointly promotes the electron and mass transfer.	-co(oh)2	58-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-39
34808047-3	2021	Theoretical calculations have described the electronic structure of (Co(ppq)DMF)-1 as a low-spin Co(II) center coupling with a triple-reduced ppq radical ligand.	co(ppq)dmf)-1	69-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-103
34808047-3	2021	Theoretical calculations have described the electronic structure of (Co(ppq)DMF)-1 as a low-spin Co(II) center coupling with a triple-reduced ppq radical ligand.	Glufosinate-P	142-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-103
34418511-12	2021	Investigation about the underlying mechanism revealed that Gaillardin exerts its action through inhibition of NF-kappaB activation and subsequently down-regulation of genes (COX-2, MMP-9, TWIST-1, and BCl-2) regulated by NF-kappaB.	gaillardin	59-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	174-179
34864969-7	2022	Current use of older COX-2 inhibitors was associated with the highest hazard ratio in patients with non-obstructive CAD, both when ascertained as pre-CCTA use (2.9-fold increase) and from time-varying use (1.8-fold increase).	ccta	150-154	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-26
34851565-12	2021	Auraptene effect the gene expression of important gene related to angiogenesis (VEGF, VEGFR2, COX2, IFNgamma).	aurapten	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-98
34862391-0	2021	Aiphanol, a native compound, suppresses angiogenesis via dual-targeting VEGFR2 and COX2.	aiphanol	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-87
34851565-14	2021	CONCLUSIONS: Overall, this study shows that Auraptene significantly suppressed angiogenesis via down-regulation of VEGF, VEGFR2, VCAM-1, TNFR-1, COX-2 and up-regulation of IFNgamma.	aurapten	44-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-150
34694468-0	2021	Correction to: Co(II) complexes of curcumin and a ferrocene-based curcuminoid: a study on photo-induced antitumor activity.	Curcumin	35-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-21
34180760-15	2021	This study provides a theoretical basis for elucidating the mechanism of mepivacaine-induced nerve cell damage, and overexpressed miR-183-5p likely become a novel strategy to combat mepivacaine-induced nerve damage.Abbreviations:miRNA: Micro RNA; PDCD4: Programmed Cell Death 4; MDA: Malondialdehyde; SOD: Superoxide Dismutase; ROS: Reactive Oxygen Species; WT: Wild Type; Mut: Mutant; UTR: Untranslated Region; IL-6: Interleukin-6; IL-1beta: Interleukin-1beta; TNF-alpha: Tumor Necrosis Factor-alpha; IL-8: Interleukin-8; COX-2: Cyclooxygenase-2; iNOS: inducible NOS; MEP: Mepivacaine.	mir-183-5p	130-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	523-528
34606846-3	2021	Preclinical studies have demonstrated that the COX-2-PGE2 pathway can promote gastrointestinal cancer development.	Dinoprostone	53-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
34463587-11	2021	Furthermore, PDTC decreased IL-1beta-induced chondrocyte apoptosis with the upregulated COL1A1, COL2A1, COL10A1 and ACAN, as well as the down-regulated MMP1, MMP13, COX2, iNOS, IL-6, TNF-alpha, NO and PGE2, which was reversed by A20 siRNA.	pyrrolidine dithiocarbamic acid	13-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	165-169
34775204-10	2021	Many of the synthesized agents show enhanced COX-1/2 properties than aspirin with better selectivity index towards COX-2 relative to COX-1.	Aspirin	69-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-120
34455232-6	2021	OA-DHZ also showed selective inhibition of COX-2 in vitro while showing gastroprotective effects when evaluated for ulcerogenic and antiulcer potential in vivo.	oa-dhz	0-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
34813026-7	2021	Celecoxib and roficoxib like selective COX-2 inhibitors also ameliorate neuroinflammation.	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-44
34813026-7	2021	Celecoxib and roficoxib like selective COX-2 inhibitors also ameliorate neuroinflammation.	roficoxib	14-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-44
34694468-0	2021	Correction to: Co(II) complexes of curcumin and a ferrocene-based curcuminoid: a study on photo-induced antitumor activity.	ferrocene	50-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-21
34694468-0	2021	Correction to: Co(II) complexes of curcumin and a ferrocene-based curcuminoid: a study on photo-induced antitumor activity.	Diarylheptanoids	66-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-21
33896320-4	2021	Molecular modelling suggested that Flu-AM4 optimally fits a hydrophobic pocket in the ACB region of FAAH, and binds to COX-2 similarly to flurbiprofen.	flu-am4	35-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-124
33896320-5	2021	In vivo studies indicated that at a dose of 10 mg/kg, Flu-AM4 was active in models of prolonged (formalin) and neuropathic (chronic constriction injury) pain and reduced the spinal expression of iNOS, COX-2, and NFkappaB in the neuropathic model.	flu-am4	54-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	201-206
33957835-0	2021	Utility of novel 2-furanones in synthesis of other heterocyclic compounds having anti-inflammatory activity with dual COX2/LOX inhibition.	butenolide	17-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-122
34338135-0	2021	Design and synthesis of novel quinazolinones conjugated ibuprofen, indole acetamide, or thioacetohydrazide as selective COX-2 inhibitors: anti-inflammatory, analgesic and anticancer activities.	Quinazolinones	30-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-125
34338135-0	2021	Design and synthesis of novel quinazolinones conjugated ibuprofen, indole acetamide, or thioacetohydrazide as selective COX-2 inhibitors: anti-inflammatory, analgesic and anticancer activities.	Ibuprofen	56-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-125
34669001-6	2021	Many authors highlighted the activity of carvacrol as a potent suppressor of COX-2 expression minimizing the acute inflammatory process, decreasing the release of some pro-inflammatory mediators such as IL-1beta, TNF-alpha, PGE2.	carvacrol	41-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-82
34338135-0	2021	Design and synthesis of novel quinazolinones conjugated ibuprofen, indole acetamide, or thioacetohydrazide as selective COX-2 inhibitors: anti-inflammatory, analgesic and anticancer activities.	indoleacetamide	67-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-125
34338135-0	2021	Design and synthesis of novel quinazolinones conjugated ibuprofen, indole acetamide, or thioacetohydrazide as selective COX-2 inhibitors: anti-inflammatory, analgesic and anticancer activities.	thioacetohydrazide	88-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-125
34338135-1	2021	Novel quinazolinones conjugated with indole acetamide (4a-c), ibuprofen (7a-e), or thioacetohydrazide (13a,b, and 14a-d) were designed to increase COX-2 selectivity.	Quinazolinones	6-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-152
34338135-1	2021	Novel quinazolinones conjugated with indole acetamide (4a-c), ibuprofen (7a-e), or thioacetohydrazide (13a,b, and 14a-d) were designed to increase COX-2 selectivity.	indoleacetamide	37-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-152
34338135-1	2021	Novel quinazolinones conjugated with indole acetamide (4a-c), ibuprofen (7a-e), or thioacetohydrazide (13a,b, and 14a-d) were designed to increase COX-2 selectivity.	Ibuprofen	62-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-152
34338135-1	2021	Novel quinazolinones conjugated with indole acetamide (4a-c), ibuprofen (7a-e), or thioacetohydrazide (13a,b, and 14a-d) were designed to increase COX-2 selectivity.	7a-e	73-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-152
34338135-1	2021	Novel quinazolinones conjugated with indole acetamide (4a-c), ibuprofen (7a-e), or thioacetohydrazide (13a,b, and 14a-d) were designed to increase COX-2 selectivity.	thioacetohydrazide	83-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-152
34338135-2	2021	The three synthesised series exhibited superior COX-2 selectivity compared with the previously reported quinazolinones and their NSAID analogue and had equipotent COX-2 selectivity as celecoxib.	Celecoxib	184-193	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	163-168
34486757-0	2021	Surfactin attenuates particulate matter-induced COX-2-dependent PGE2 production in human gingival fibroblasts by inhibiting TLR2 and TLR4/MyD88/NADPH oxidase/ROS/PI3K/Akt/NF-kappaB signaling pathway.	surfactin peptide	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-53
34486757-0	2021	Surfactin attenuates particulate matter-induced COX-2-dependent PGE2 production in human gingival fibroblasts by inhibiting TLR2 and TLR4/MyD88/NADPH oxidase/ROS/PI3K/Akt/NF-kappaB signaling pathway.	Dinoprostone	64-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-53
34486757-15	2021	PM-induced COX-2/PGE2 increase was effectively reversed by surfactin through the disruption of regulatory pathway.	Dinoprostone	17-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-16
34486757-15	2021	PM-induced COX-2/PGE2 increase was effectively reversed by surfactin through the disruption of regulatory pathway.	surfactin peptide	59-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-16
34734697-3	2021	Here we realized an enantioselective Michael reaction of silyl ketene imines to 1-acrylpyrazoles using a chiral N,N"-dioxide-Co(II) complex.	silyl ketene imines	57-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-131
34846656-0	2022	High-efficiency adsorption of Cd(II) and Co(II) by ethylenediaminetetraacetic dianhydride-modified orange peel as a novel synthesized adsorbent.	Ethylenediaminetetraacetic dianhydride	51-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-47
34846656-3	2022	In this study, a novel adsorbent based on orange peel was synthesized for the first time by introducing abundant -COO groups with ethylenediaminetetraacetic dianhydride (EDTAD) to eliminate Cd(II) and Co(II) of sewage solution.	Ethylenediaminetetraacetic dianhydride	130-168	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	201-207
34846656-3	2022	In this study, a novel adsorbent based on orange peel was synthesized for the first time by introducing abundant -COO groups with ethylenediaminetetraacetic dianhydride (EDTAD) to eliminate Cd(II) and Co(II) of sewage solution.	edtad	170-175	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	201-207
34822026-4	2022	Furthermore, we describe other potential benefits related to aspirin-triggered lipoxins and resolvins while illustrating how NSAIDs interfere with COX-1, COX-2, SARS-CoV-2/ SARS-CoV-2 ORF protein-dependent activation of caspases and their subsequent mitochondrial dysfunction, endoplasmic reticulum stress, apoptosis and necroptosis which were associated with COVID-19 complications.	Aspirin	61-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	154-159
34867421-6	2021	We observed that AM404 and acetaminophen significantly and concentration-dependent inhibited IL-1beta-induced release of PGE2, independent of cyclooxygenases (COX)-1 and COX-2 enzymatic activity as well as COX-2 mRNA and protein levels in SK-N-SH-cells.	N-(4-hydroxyphenyl)arachidonylamide	17-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	170-175
34867421-6	2021	We observed that AM404 and acetaminophen significantly and concentration-dependent inhibited IL-1beta-induced release of PGE2, independent of cyclooxygenases (COX)-1 and COX-2 enzymatic activity as well as COX-2 mRNA and protein levels in SK-N-SH-cells.	N-(4-hydroxyphenyl)arachidonylamide	17-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	206-211
34867421-6	2021	We observed that AM404 and acetaminophen significantly and concentration-dependent inhibited IL-1beta-induced release of PGE2, independent of cyclooxygenases (COX)-1 and COX-2 enzymatic activity as well as COX-2 mRNA and protein levels in SK-N-SH-cells.	Acetaminophen	27-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	170-175
34867421-6	2021	We observed that AM404 and acetaminophen significantly and concentration-dependent inhibited IL-1beta-induced release of PGE2, independent of cyclooxygenases (COX)-1 and COX-2 enzymatic activity as well as COX-2 mRNA and protein levels in SK-N-SH-cells.	Acetaminophen	27-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	206-211
34734697-3	2021	Here we realized an enantioselective Michael reaction of silyl ketene imines to 1-acrylpyrazoles using a chiral N,N"-dioxide-Co(II) complex.	1-acrylpyrazoles	80-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-131
34785631-2	2021	In this article, they found that astrocytes that were pretreated with paeonol significantly rescued MPP+-induced cell viability reduction, and inhibited up-regulation of cell apoptosis, caspase-1 activity, COX2, iNOS, and Bax/Bcl-2 ratio, as well as p-JNK and p-ERK.	paeonol	70-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	206-210
34734697-3	2021	Here we realized an enantioselective Michael reaction of silyl ketene imines to 1-acrylpyrazoles using a chiral N,N"-dioxide-Co(II) complex.	n,n"-dioxide	112-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-131
34869987-3	2021	The photocatalytic activity can be improved by modifying the framework by exchanging the Zn(II) ions (ZIF-8) and Co(II) ions (ZIF-67) with a more photocatalytically active metal(II) ion to form an efficient bimetallic ZIF photocatalyst.	metal(ii)	172-181	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-119
34824594-9	2021	ES suppressed the expression of PGE2 and 6-Keot-PGF1 alpha, and the ratio of IC50 (COX-1)/IC50 (COX-2) of ES was 3.15, which indicated that ES could selectively inhibit COX-2.	Einsteinium	0-2	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-101
34824594-9	2021	ES suppressed the expression of PGE2 and 6-Keot-PGF1 alpha, and the ratio of IC50 (COX-1)/IC50 (COX-2) of ES was 3.15, which indicated that ES could selectively inhibit COX-2.	Einsteinium	0-2	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	169-174
34824594-9	2021	ES suppressed the expression of PGE2 and 6-Keot-PGF1 alpha, and the ratio of IC50 (COX-1)/IC50 (COX-2) of ES was 3.15, which indicated that ES could selectively inhibit COX-2.	Dinoprostone	32-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	169-174
34824594-9	2021	ES suppressed the expression of PGE2 and 6-Keot-PGF1 alpha, and the ratio of IC50 (COX-1)/IC50 (COX-2) of ES was 3.15, which indicated that ES could selectively inhibit COX-2.	Einsteinium	106-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-101
34824594-9	2021	ES suppressed the expression of PGE2 and 6-Keot-PGF1 alpha, and the ratio of IC50 (COX-1)/IC50 (COX-2) of ES was 3.15, which indicated that ES could selectively inhibit COX-2.	Einsteinium	106-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	169-174
34824594-9	2021	ES suppressed the expression of PGE2 and 6-Keot-PGF1 alpha, and the ratio of IC50 (COX-1)/IC50 (COX-2) of ES was 3.15, which indicated that ES could selectively inhibit COX-2.	Einsteinium	140-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-101
34824594-9	2021	ES suppressed the expression of PGE2 and 6-Keot-PGF1 alpha, and the ratio of IC50 (COX-1)/IC50 (COX-2) of ES was 3.15, which indicated that ES could selectively inhibit COX-2.	Einsteinium	140-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	169-174
34824594-12	2021	Conclusion: The results suggested that ES could selectively inhibit the activity of COX-2, and the anti-inflammatory effect of ES was associated with the inhibition of IL-1beta, IL-6, and TNF-alpha via negative regulation of MAPK and NF-kappaB signaling pathways in LPS-induced THP-1 cells.	Einsteinium	39-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-89
34824594-12	2021	Conclusion: The results suggested that ES could selectively inhibit the activity of COX-2, and the anti-inflammatory effect of ES was associated with the inhibition of IL-1beta, IL-6, and TNF-alpha via negative regulation of MAPK and NF-kappaB signaling pathways in LPS-induced THP-1 cells.	Einsteinium	127-129	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-89
34188314-0	2021	Synthesis and characterization of new thiazole-based Co(II) and Cu(II) complexes; therapeutic function of thiazole towards COVID-19 in comparing to current antivirals in treatment protocol.	Thiazoles	38-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-59
34702033-2	2021	Herein, the electric active CoII ion is selected to coordinate with redox-active S-rich tetrathiafulvalene (TTF) derivatives to create two TTF-Co-MOFs, formulated as (Co2(py-TTF-py)2(BDC)2) 2DMF H2O (TTF-Co-MOF 1) and (Co2(py-TTF-py)2(BPDC)2) 3DMF 3H2O (TTF-Co-MOF 2), where py-TTF-py = 2,6-bis(4"-pyridyl)tetrathiafulvalene, H2BDC = terephthalic acid, H2BPDC = biphenyl-4,4"-dicarboxylic acid, and DMF = N,N-dimethylformamide.	Water	195-198	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-32
34188314-0	2021	Synthesis and characterization of new thiazole-based Co(II) and Cu(II) complexes; therapeutic function of thiazole towards COVID-19 in comparing to current antivirals in treatment protocol.	Thiazoles	106-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-59
34188314-1	2021	Two thiazole-based complexes were prepared from Co(II) and Cu(II) ions.	Thiazoles	4-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-54
34766335-8	2022	In contrast, COX-2 inhibition blocked the formation of both prostaglandins.	Prostaglandins	60-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
34782424-7	2021	Quantitative real-time PCR was performed with specific COX-2 oligonucleotides and the endogenous GAPDH gene.	Oligonucleotides	61-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-60
34743300-4	2021	Fe(II), Co(II), and Ni(II) metal complexes of the novel Schiff base ligand were synthesized and characterized.	Schiff Bases	56-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	8-14
34618449-2	2021	The approach relies on the in situ reduction of Co(II) by H-BPin in the presence of bisphosphine ligands generating catalytically active Co(I) hydride complexes.	h-bpin	58-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-54
34618449-2	2021	The approach relies on the in situ reduction of Co(II) by H-BPin in the presence of bisphosphine ligands generating catalytically active Co(I) hydride complexes.	bisphosphine	84-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-54
34618449-2	2021	The approach relies on the in situ reduction of Co(II) by H-BPin in the presence of bisphosphine ligands generating catalytically active Co(I) hydride complexes.	NAD	137-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-54
34670095-1	2021	A brief, efficient method has been developed for the removal of the allyl protecting group from allyl carboxylic esters using a Co(II)/TBHP/(Me2SiH)2O catalytic system.	carboxylic esters	102-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	128-134
34670095-1	2021	A brief, efficient method has been developed for the removal of the allyl protecting group from allyl carboxylic esters using a Co(II)/TBHP/(Me2SiH)2O catalytic system.	tert-Butylhydroperoxide	135-139	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	128-134
34670095-1	2021	A brief, efficient method has been developed for the removal of the allyl protecting group from allyl carboxylic esters using a Co(II)/TBHP/(Me2SiH)2O catalytic system.	(me2sih)2o	140-150	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	128-134
34726676-0	2021	Field-induced single-ion magnets exhibiting tri-axial anisotropy in a 1D Co(II) coordination polymer with a rigid ligand 4,4"-(buta-1,3-diyne-1,4-diyl)dibenzoate.	4,4"-(buta-1,3-diyne-1,4-diyl)dibenzoate	121-161	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-79
34643082-2	2021	Pyrazoline-pyrimidine hybrid (23g), (3-acetylcoumarin derivative of pyrrolidin-1-yl)benzenesulfonamide (27), and tacrine derivatives of (pyrrolidin-1-yl)benzenesulfonamide (31, 38) displayed excellent in vitro COX-2 inhibition having IC50 value in the nanomolar range.	pyrazoline-pyrimidine	0-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	210-215
34643082-2	2021	Pyrazoline-pyrimidine hybrid (23g), (3-acetylcoumarin derivative of pyrrolidin-1-yl)benzenesulfonamide (27), and tacrine derivatives of (pyrrolidin-1-yl)benzenesulfonamide (31, 38) displayed excellent in vitro COX-2 inhibition having IC50 value in the nanomolar range.	3-acetylcoumarin	36-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	210-215
34643082-2	2021	Pyrazoline-pyrimidine hybrid (23g), (3-acetylcoumarin derivative of pyrrolidin-1-yl)benzenesulfonamide (27), and tacrine derivatives of (pyrrolidin-1-yl)benzenesulfonamide (31, 38) displayed excellent in vitro COX-2 inhibition having IC50 value in the nanomolar range.	pyrrolidin-1-yl)benzenesulfonamide	68-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	210-215
34636819-3	2021	The reaction of 6,6"-bis(2-tbutyl-tetrazol-5-yl)-2,2"-bipyridine (L2) with hydrated FeII(ClO4)2 afforded a 8-coordinate Fe(II) compound, (FeII(L2)2)(ClO4)2 (3); however its reaction with hydrated CoII(ClO4)2 resulted in 6-coordinate (CoII(L2)2)(ClO4)2.	6,6"-bis(2-tbutyl-tetrazol-5-yl)-2,2"-bipyridine	16-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	196-200
34636819-3	2021	The reaction of 6,6"-bis(2-tbutyl-tetrazol-5-yl)-2,2"-bipyridine (L2) with hydrated FeII(ClO4)2 afforded a 8-coordinate Fe(II) compound, (FeII(L2)2)(ClO4)2 (3); however its reaction with hydrated CoII(ClO4)2 resulted in 6-coordinate (CoII(L2)2)(ClO4)2.	6,6"-bis(2-tbutyl-tetrazol-5-yl)-2,2"-bipyridine	16-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	234-238
34636819-3	2021	The reaction of 6,6"-bis(2-tbutyl-tetrazol-5-yl)-2,2"-bipyridine (L2) with hydrated FeII(ClO4)2 afforded a 8-coordinate Fe(II) compound, (FeII(L2)2)(ClO4)2 (3); however its reaction with hydrated CoII(ClO4)2 resulted in 6-coordinate (CoII(L2)2)(ClO4)2.	l2	66-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	196-200
34636819-3	2021	The reaction of 6,6"-bis(2-tbutyl-tetrazol-5-yl)-2,2"-bipyridine (L2) with hydrated FeII(ClO4)2 afforded a 8-coordinate Fe(II) compound, (FeII(L2)2)(ClO4)2 (3); however its reaction with hydrated CoII(ClO4)2 resulted in 6-coordinate (CoII(L2)2)(ClO4)2.	l2	66-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	234-238
34732120-0	2022	Celastrol inhibits the proliferation and induces apoptosis of colorectal cancer cells via downregulating NF-kappaB/COX-2 signaling pathways.	celastrol	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-120
34732120-9	2022	Mechanistic protein expression revealed that celastrol suppressed the expression of COX-2 by inhibiting the phosphorylation of NF-kappaB p65 and subsequently leading to cytoplasmic retention of p65 protein, thereby inhibiting its nuclear translocation and transcription activities.	celastrol	45-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-89
34732120-10	2022	CONCLUSION: These findings indicate that celastrol is an effective inhibitor for CRC, regulating the NF-kappaB/COX-2 pathway, leading to the inhibition of cell proliferation characterized by cell cycle arrest and caspase-dependent apoptosis, providing a potential alternative therapeutic agent for CRC patients.	celastrol	41-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	111-116
34636819-3	2021	The reaction of 6,6"-bis(2-tbutyl-tetrazol-5-yl)-2,2"-bipyridine (L2) with hydrated FeII(ClO4)2 afforded a 8-coordinate Fe(II) compound, (FeII(L2)2)(ClO4)2 (3); however its reaction with hydrated CoII(ClO4)2 resulted in 6-coordinate (CoII(L2)2)(ClO4)2.	(feii(l2)2)(clo4)2	137-155	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	196-200
34726676-1	2021	Herein a 1D Co(II) coordination polymer of formula (Co(eta1-L1)(eta2-L1)(py)2(H2O))n (CoCP) has been synthesised using the rigid H2L1 proligand, containing a long spacer bearing two triple bonds.	Polymers	32-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-18
34726676-1	2021	Herein a 1D Co(II) coordination polymer of formula (Co(eta1-L1)(eta2-L1)(py)2(H2O))n (CoCP) has been synthesised using the rigid H2L1 proligand, containing a long spacer bearing two triple bonds.	Water	78-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-18
34726676-1	2021	Herein a 1D Co(II) coordination polymer of formula (Co(eta1-L1)(eta2-L1)(py)2(H2O))n (CoCP) has been synthesised using the rigid H2L1 proligand, containing a long spacer bearing two triple bonds.	cocp	86-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-18
34119724-4	2021	Co3O4 NPs play as electron shuttles in the catalytic permanganate oxidation process involving one-electron transfer with the oxidation of  CoII to  CoIII by permanganate and the formation of colloidal manganese dioxide (MnO2), as well as the reduction of the newly formed  CoIII to  CoII by organics and the production of oxidized organic byproducts.	co3o4	0-5	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-143
34619468-4	2021	Compounds 6d and 11f showed excellent inhibitory activities against both COX-2 and sEH (COX-2 IC50 = 0.043 and 0.048 microM; sEH IC50 = 83.58 and 83.52 muM, respectively).	5-[(3s)-3-(2-Methoxybiphenyl-4-Yl)but-1-Yn-1-Yl]-6-Methylpyrimidine-2,4-Diamine	17-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-78
34619468-4	2021	Compounds 6d and 11f showed excellent inhibitory activities against both COX-2 and sEH (COX-2 IC50 = 0.043 and 0.048 microM; sEH IC50 = 83.58 and 83.52 muM, respectively).	5-[(3s)-3-(2-Methoxybiphenyl-4-Yl)but-1-Yn-1-Yl]-6-Methylpyrimidine-2,4-Diamine	17-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-93
34628222-4	2021	In particular, corniculatolide B significantly inhibited the protein expression of COX-2 and the mRNA expressions of TNF-alpha, IL-1beta and IL-6 by inhibiting of NF-kappaB signaling in intestinal epithelial cells induced by lipopolysaccharide treatment.	corniculatolide b	15-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
34464816-0	2021	Novel 1,5-diaryl pyrazole-3-carboxamides as selective COX-2/sEH inhibitors with analgesic, anti-inflammatory, and lower cardiotoxicity effects.	1,5-diaryl pyrazole-3-carboxamides	6-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-59
34464816-2	2021	As a result, a new series of 1,5-diaryl pyrazole carboxamides 19-31 was synthesized as selective COX-2/sEH inhibitors with analgesic, anti-inflammatory, and lower cardiotoxic properties.	1,5-diaryl pyrazole carboxamides	29-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
34464816-6	2021	Moreover, compounds 20, 22, and 29 were the most potent dual COX-2/sEH inhibitors, with IC50 values of 0.95, 0.80, and 0.85 nM against sEH, respectively, and were more potent than the standard AUDA (IC50 = 1.2 nM).	12-(3-adamantan-1-ylureido)dodecanoic acid	193-197	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-66
34182020-5	2021	Thus, the relative COX-2 selectivity of traditional NSAIDs correlates with their cardiovascular risk profile, being more favorable for non-selective NSAIDs, such as naproxen and low-dose ibuprofen, and less favorable for more COX-2 selective agents, such as diclofenac.	Naproxen	165-173	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-24
34182020-5	2021	Thus, the relative COX-2 selectivity of traditional NSAIDs correlates with their cardiovascular risk profile, being more favorable for non-selective NSAIDs, such as naproxen and low-dose ibuprofen, and less favorable for more COX-2 selective agents, such as diclofenac.	Ibuprofen	187-196	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-24
34182020-5	2021	Thus, the relative COX-2 selectivity of traditional NSAIDs correlates with their cardiovascular risk profile, being more favorable for non-selective NSAIDs, such as naproxen and low-dose ibuprofen, and less favorable for more COX-2 selective agents, such as diclofenac.	Diclofenac	258-268	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-24
34411436-8	2021	Accordingly, novel N -acyl hydrazone derivatives were synthesized as new COX-2 inhibitors in this study.	n -acyl hydrazone	19-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-78
34411436-10	2021	A methyl sulfonyl pharmacophore was added to the structure in order to increase the affinity for the polar side pocket present in the COX-2 enzyme.	methyl sulfonyl	2-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-139
34119724-4	2021	Co3O4 NPs play as electron shuttles in the catalytic permanganate oxidation process involving one-electron transfer with the oxidation of  CoII to  CoIII by permanganate and the formation of colloidal manganese dioxide (MnO2), as well as the reduction of the newly formed  CoIII to  CoII by organics and the production of oxidized organic byproducts.	co3o4	0-5	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	283-287
34600695-6	2021	Further, RT-PCR for inflammatory mediators (TRPA1, NF-kappaB, PPAR-gamma, COX-2, IL-6, TNF, FPR2, FAAH, MAGL, and IL-12A) induced by carrageenan, NLRP3 inflammasome activation, and the cell viability were then accessed.	Carrageenan	133-144	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
34402589-3	2021	Here, we reported that Cd (0-500 nM) significantly promoted the proliferation of HepG2 cells as demonstrated by elevated cell viability, more EdU-positive cells and increased gene expression of KI-67 and COX-2.	Cadmium	23-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	204-209
34688822-5	2021	The results of docking studies of the 3beta-palmitoyloxy esters of olean-12-ene with NF-kappaB and with COX-2 receptors were consistent with possible molecular mechanisms of the anti-inflammatory activity.	3beta-palmitoyloxy esters	38-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
34688822-5	2021	The results of docking studies of the 3beta-palmitoyloxy esters of olean-12-ene with NF-kappaB and with COX-2 receptors were consistent with possible molecular mechanisms of the anti-inflammatory activity.	Olean-12-ene	67-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
34549505-2	2021	Herein, the bottleneck is largely overcome by constructing a nitridation-induced compressively strained-interface N-doped palladium/amorphous cobalt (II) interface (N-Pd/A-Co(II)), which dramatically boosts HER performance in alkaline condition.	nitridation	61-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	172-178
34514729-9	2021	Further investigations revealed that crocetin treatment inhibited the expression of STAT3 regulated genes (Bcl-2, Bcl-xL, cyclin D1, survivin, VEGF, COX-2, and MMP-9).	crocetin	37-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	149-154
34486189-5	2021	We employed an immortalized endothelial cell line (bEnd.3) to mimic a BBB monolayer model in vitro and investigated the effect of harpagoside on BBB and found that harpagoside alleviated Ang II-induced BBB destruction, inhibited Ang II-associated cytotoxicity in a concentration-dependent manner and attenuated Ang II-induced reactive oxygen species (ROS) impair by downregulation of Nox2, Nox4, and COX-2.	harpagoside	164-175	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	400-405
34486189-5	2021	We employed an immortalized endothelial cell line (bEnd.3) to mimic a BBB monolayer model in vitro and investigated the effect of harpagoside on BBB and found that harpagoside alleviated Ang II-induced BBB destruction, inhibited Ang II-associated cytotoxicity in a concentration-dependent manner and attenuated Ang II-induced reactive oxygen species (ROS) impair by downregulation of Nox2, Nox4, and COX-2.	Reactive Oxygen Species	351-354	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	400-405
34548209-4	2021	HCbl is known to be a transient species where the oxidation state of the Co is variable; Co(I)-H+   Co(II)-H   Co(III)-H-.	NAD	89-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-106
34548209-4	2021	HCbl is known to be a transient species where the oxidation state of the Co is variable; Co(I)-H+   Co(II)-H   Co(III)-H-.	co(iii)	111-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-106
34549505-2	2021	Herein, the bottleneck is largely overcome by constructing a nitridation-induced compressively strained-interface N-doped palladium/amorphous cobalt (II) interface (N-Pd/A-Co(II)), which dramatically boosts HER performance in alkaline condition.	Palladium	122-131	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	172-178
34549505-2	2021	Herein, the bottleneck is largely overcome by constructing a nitridation-induced compressively strained-interface N-doped palladium/amorphous cobalt (II) interface (N-Pd/A-Co(II)), which dramatically boosts HER performance in alkaline condition.	Cobalt(2+)	142-153	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	172-178
34549505-6	2021	And the amorphous Co(II) component accelerates the water dissociation.	Water	51-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-24
34549505-7	2021	Consequently, the cooperative effect between the compressed N-doped Pd and amorphous Co(II) creates the impressive HER performance in alkaline condition, highlighting the importance of the functional interface to develop efficient electrocatalysts for HER and beyond.	n-doped	60-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-91
34549505-7	2021	Consequently, the cooperative effect between the compressed N-doped Pd and amorphous Co(II) creates the impressive HER performance in alkaline condition, highlighting the importance of the functional interface to develop efficient electrocatalysts for HER and beyond.	Palladium	68-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-91
34642705-2	2021	Pt2+-linked M6L3 nanoprisms with cobalt-porphyrin walls were prepared and their redox properties were evaluated electrochemically and chemically, leading to the first time that cobalt-porphyrin nanocages have been characterized in CoI, CoII, and CoIII states.	cobalt porphyrin	177-193	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	236-240
34450150-1	2021	Microcrystalline cellulose (MCC), magnesium sulfate hexahydrate, and trisodium citrate were reacted in ammonia bath in an aqueous solution to prepare a MCC-magnesium hydroxide (MH) composite adsorbent, which was used to adsorb heavy metal Co(II) ion.	microcrystalline cellulose	0-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	239-245
34770990-10	2021	Moreover, analysis of the binding modes of 8a,e,f into COX-2 revealed partial superposition with the co-crystallized ligand, SC-558 with the formation of essential hydrogen bonds, electrostatic, or hydrophobic interactions with the key amino acid His90 and Arg513.	SC 558	125-131	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-60
34770990-10	2021	Moreover, analysis of the binding modes of 8a,e,f into COX-2 revealed partial superposition with the co-crystallized ligand, SC-558 with the formation of essential hydrogen bonds, electrostatic, or hydrophobic interactions with the key amino acid His90 and Arg513.	Hydrogen	164-172	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-60
34450150-1	2021	Microcrystalline cellulose (MCC), magnesium sulfate hexahydrate, and trisodium citrate were reacted in ammonia bath in an aqueous solution to prepare a MCC-magnesium hydroxide (MH) composite adsorbent, which was used to adsorb heavy metal Co(II) ion.	microcrystalline cellulose	28-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	239-245
34450150-1	2021	Microcrystalline cellulose (MCC), magnesium sulfate hexahydrate, and trisodium citrate were reacted in ammonia bath in an aqueous solution to prepare a MCC-magnesium hydroxide (MH) composite adsorbent, which was used to adsorb heavy metal Co(II) ion.	Magnesium sulfate hexahydrate	34-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	239-245
34450150-1	2021	Microcrystalline cellulose (MCC), magnesium sulfate hexahydrate, and trisodium citrate were reacted in ammonia bath in an aqueous solution to prepare a MCC-magnesium hydroxide (MH) composite adsorbent, which was used to adsorb heavy metal Co(II) ion.	trisodium citrate	69-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	239-245
34450150-1	2021	Microcrystalline cellulose (MCC), magnesium sulfate hexahydrate, and trisodium citrate were reacted in ammonia bath in an aqueous solution to prepare a MCC-magnesium hydroxide (MH) composite adsorbent, which was used to adsorb heavy metal Co(II) ion.	Ammonia	103-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	239-245
34450150-1	2021	Microcrystalline cellulose (MCC), magnesium sulfate hexahydrate, and trisodium citrate were reacted in ammonia bath in an aqueous solution to prepare a MCC-magnesium hydroxide (MH) composite adsorbent, which was used to adsorb heavy metal Co(II) ion.	microcrystalline cellulose	152-155	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	239-245
34450150-1	2021	Microcrystalline cellulose (MCC), magnesium sulfate hexahydrate, and trisodium citrate were reacted in ammonia bath in an aqueous solution to prepare a MCC-magnesium hydroxide (MH) composite adsorbent, which was used to adsorb heavy metal Co(II) ion.	Magnesium Hydroxide	156-175	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	239-245
34450150-1	2021	Microcrystalline cellulose (MCC), magnesium sulfate hexahydrate, and trisodium citrate were reacted in ammonia bath in an aqueous solution to prepare a MCC-magnesium hydroxide (MH) composite adsorbent, which was used to adsorb heavy metal Co(II) ion.	mh	177-179	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	239-245
34450150-3	2021	The optimal process parameters include an MCC-MH dosage of 2.5 mg/mL, a contact reaction equilibrium time of 50 min, a Co(II) solution pH of 6.0-8.0, an initial Co(II) concentration of 300 mg/L, and a temperature of 303 K. The removal rate of Co(II) solution by MCC-MH was as high as 97.67%, and the maximum adsorption capacity of MCC-MH reached 153.84 mg/g under these optimal conditions.	mcc-mh	262-268	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-125
34450150-3	2021	The optimal process parameters include an MCC-MH dosage of 2.5 mg/mL, a contact reaction equilibrium time of 50 min, a Co(II) solution pH of 6.0-8.0, an initial Co(II) concentration of 300 mg/L, and a temperature of 303 K. The removal rate of Co(II) solution by MCC-MH was as high as 97.67%, and the maximum adsorption capacity of MCC-MH reached 153.84 mg/g under these optimal conditions.	mcc-mh	262-268	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	161-167
34450150-3	2021	The optimal process parameters include an MCC-MH dosage of 2.5 mg/mL, a contact reaction equilibrium time of 50 min, a Co(II) solution pH of 6.0-8.0, an initial Co(II) concentration of 300 mg/L, and a temperature of 303 K. The removal rate of Co(II) solution by MCC-MH was as high as 97.67%, and the maximum adsorption capacity of MCC-MH reached 153.84 mg/g under these optimal conditions.	mcc-mh	262-268	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	243-249
34450150-3	2021	The optimal process parameters include an MCC-MH dosage of 2.5 mg/mL, a contact reaction equilibrium time of 50 min, a Co(II) solution pH of 6.0-8.0, an initial Co(II) concentration of 300 mg/L, and a temperature of 303 K. The removal rate of Co(II) solution by MCC-MH was as high as 97.67%, and the maximum adsorption capacity of MCC-MH reached 153.84 mg/g under these optimal conditions.	microcrystalline cellulose	331-335	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-125
34450150-3	2021	The optimal process parameters include an MCC-MH dosage of 2.5 mg/mL, a contact reaction equilibrium time of 50 min, a Co(II) solution pH of 6.0-8.0, an initial Co(II) concentration of 300 mg/L, and a temperature of 303 K. The removal rate of Co(II) solution by MCC-MH was as high as 97.67%, and the maximum adsorption capacity of MCC-MH reached 153.84 mg/g under these optimal conditions.	microcrystalline cellulose	331-335	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	161-167
34450150-3	2021	The optimal process parameters include an MCC-MH dosage of 2.5 mg/mL, a contact reaction equilibrium time of 50 min, a Co(II) solution pH of 6.0-8.0, an initial Co(II) concentration of 300 mg/L, and a temperature of 303 K. The removal rate of Co(II) solution by MCC-MH was as high as 97.67%, and the maximum adsorption capacity of MCC-MH reached 153.84 mg/g under these optimal conditions.	microcrystalline cellulose	331-335	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	243-249
34450150-3	2021	The optimal process parameters include an MCC-MH dosage of 2.5 mg/mL, a contact reaction equilibrium time of 50 min, a Co(II) solution pH of 6.0-8.0, an initial Co(II) concentration of 300 mg/L, and a temperature of 303 K. The removal rate of Co(II) solution by MCC-MH was as high as 97.67%, and the maximum adsorption capacity of MCC-MH reached 153.84 mg/g under these optimal conditions.	mh	335-337	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-125
34450150-3	2021	The optimal process parameters include an MCC-MH dosage of 2.5 mg/mL, a contact reaction equilibrium time of 50 min, a Co(II) solution pH of 6.0-8.0, an initial Co(II) concentration of 300 mg/L, and a temperature of 303 K. The removal rate of Co(II) solution by MCC-MH was as high as 97.67%, and the maximum adsorption capacity of MCC-MH reached 153.84 mg/g under these optimal conditions.	mh	335-337	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	161-167
34450150-3	2021	The optimal process parameters include an MCC-MH dosage of 2.5 mg/mL, a contact reaction equilibrium time of 50 min, a Co(II) solution pH of 6.0-8.0, an initial Co(II) concentration of 300 mg/L, and a temperature of 303 K. The removal rate of Co(II) solution by MCC-MH was as high as 97.67%, and the maximum adsorption capacity of MCC-MH reached 153.84 mg/g under these optimal conditions.	mh	335-337	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	243-249
34450150-4	2021	The adsorption isotherm of Co(II) conformed to the Langmuir model, the kinetic data of Co(II) conformed to the pseudo-second-order kinetic model, and the adsorption of Co(II) by MCC-MH was a spontaneous endothermic reaction under the optimized conditions.	mcc-mh	178-184	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-33
34450150-4	2021	The adsorption isotherm of Co(II) conformed to the Langmuir model, the kinetic data of Co(II) conformed to the pseudo-second-order kinetic model, and the adsorption of Co(II) by MCC-MH was a spontaneous endothermic reaction under the optimized conditions.	mcc-mh	178-184	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-93
34450150-4	2021	The adsorption isotherm of Co(II) conformed to the Langmuir model, the kinetic data of Co(II) conformed to the pseudo-second-order kinetic model, and the adsorption of Co(II) by MCC-MH was a spontaneous endothermic reaction under the optimized conditions.	mcc-mh	178-184	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	168-174
34450150-5	2021	Analytical studies showed that Co(II) adsorption on MCC-MH composites is affected by chemical adsorption and involves the influence of intraparticle diffusion to a certain extent.	microcrystalline cellulose	52-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-37
34450150-5	2021	Analytical studies showed that Co(II) adsorption on MCC-MH composites is affected by chemical adsorption and involves the influence of intraparticle diffusion to a certain extent.	mh	56-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-37
34834697-9	2021	When RAW264.7 and HEK293T cells were treated with Hp-ME, NO production was decreased dose-dependently without cytotoxicity and the mRNA levels of iNOS, COX-2, and TNF-alpha were decreased.	hp-me	50-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-157
34759823-8	2021	Moreover, diphyllin exhibited good COX-2 inhibitory activity with the IC50 value at 1.29 +- 0.14 muM, whereas indomethacin was 1.22 +- 0.08 muM.	diphyllin	10-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40
34586126-2	2021	Treatment of the PtII2PdII2 tetranuclear complex (Pd2{Pt(NH3)2(D-pen)2}2) ((1); D-H2pen = D-penicillamine) with CoX2 (X = Cl, Br) provided (PtII2PdII2CoII2)n coordination polymers (Co2(H2O)6(1))X4 ((2)X4), in which the PtII2PdII2 units of (1) are linked by (Co2(mu-H2O)(H2O)5)4+ moieties in a 3D network structure.	Water	185-188	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-116
34586126-2	2021	Treatment of the PtII2PdII2 tetranuclear complex (Pd2{Pt(NH3)2(D-pen)2}2) ((1); D-H2pen = D-penicillamine) with CoX2 (X = Cl, Br) provided (PtII2PdII2CoII2)n coordination polymers (Co2(H2O)6(1))X4 ((2)X4), in which the PtII2PdII2 units of (1) are linked by (Co2(mu-H2O)(H2O)5)4+ moieties in a 3D network structure.	Water	265-268	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-116
34586126-2	2021	Treatment of the PtII2PdII2 tetranuclear complex (Pd2{Pt(NH3)2(D-pen)2}2) ((1); D-H2pen = D-penicillamine) with CoX2 (X = Cl, Br) provided (PtII2PdII2CoII2)n coordination polymers (Co2(H2O)6(1))X4 ((2)X4), in which the PtII2PdII2 units of (1) are linked by (Co2(mu-H2O)(H2O)5)4+ moieties in a 3D network structure.	Water	270-273	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-116
34586126-3	2021	(2)X4 showed a colour change from orange to dark green upon dehydration, reflecting the geometrical conversion of the CoII centres in (Co2(mu-H2O)(H2O)5)4+ from an octahedron to a tetrahedron by the removal of aqua ligands.	Water	142-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-122
34586126-3	2021	(2)X4 showed a colour change from orange to dark green upon dehydration, reflecting the geometrical conversion of the CoII centres in (Co2(mu-H2O)(H2O)5)4+ from an octahedron to a tetrahedron by the removal of aqua ligands.	Water	147-150	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-122
34586126-3	2021	(2)X4 showed a colour change from orange to dark green upon dehydration, reflecting the geometrical conversion of the CoII centres in (Co2(mu-H2O)(H2O)5)4+ from an octahedron to a tetrahedron by the removal of aqua ligands.	octahedron	164-174	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-122
34586126-4	2021	While both (2)Cl4 and (2)Br4 electrochemically catalysed water reduction to H2 in the solid state due to the presence of PdII active centres, water oxidation to O2 was catalysed only by (2)Br4, which is ascribed to the presence of Br- ions that mediate the catalytic reactions that occurred at CoII active centres.	(2)cl4	11-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	294-298
34586126-4	2021	While both (2)Cl4 and (2)Br4 electrochemically catalysed water reduction to H2 in the solid state due to the presence of PdII active centres, water oxidation to O2 was catalysed only by (2)Br4, which is ascribed to the presence of Br- ions that mediate the catalytic reactions that occurred at CoII active centres.	(2)br4	22-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	294-298
34586126-4	2021	While both (2)Cl4 and (2)Br4 electrochemically catalysed water reduction to H2 in the solid state due to the presence of PdII active centres, water oxidation to O2 was catalysed only by (2)Br4, which is ascribed to the presence of Br- ions that mediate the catalytic reactions that occurred at CoII active centres.	Water	57-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	294-298
34586126-4	2021	While both (2)Cl4 and (2)Br4 electrochemically catalysed water reduction to H2 in the solid state due to the presence of PdII active centres, water oxidation to O2 was catalysed only by (2)Br4, which is ascribed to the presence of Br- ions that mediate the catalytic reactions that occurred at CoII active centres.	Deuterium	76-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	294-298
34586126-4	2021	While both (2)Cl4 and (2)Br4 electrochemically catalysed water reduction to H2 in the solid state due to the presence of PdII active centres, water oxidation to O2 was catalysed only by (2)Br4, which is ascribed to the presence of Br- ions that mediate the catalytic reactions that occurred at CoII active centres.	Water	142-147	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	294-298
34586126-4	2021	While both (2)Cl4 and (2)Br4 electrochemically catalysed water reduction to H2 in the solid state due to the presence of PdII active centres, water oxidation to O2 was catalysed only by (2)Br4, which is ascribed to the presence of Br- ions that mediate the catalytic reactions that occurred at CoII active centres.	Oxygen	161-163	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	294-298
34586126-4	2021	While both (2)Cl4 and (2)Br4 electrochemically catalysed water reduction to H2 in the solid state due to the presence of PdII active centres, water oxidation to O2 was catalysed only by (2)Br4, which is ascribed to the presence of Br- ions that mediate the catalytic reactions that occurred at CoII active centres.	(2)br4	186-192	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	294-298
34586126-4	2021	While both (2)Cl4 and (2)Br4 electrochemically catalysed water reduction to H2 in the solid state due to the presence of PdII active centres, water oxidation to O2 was catalysed only by (2)Br4, which is ascribed to the presence of Br- ions that mediate the catalytic reactions that occurred at CoII active centres.	Bromine	231-233	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	294-298
34700376-7	2021	In HCAE cells, overexpressed genes included EFNA1 and LIF, two genes commonly upregulated in colorectal cancer and associated with poor patient outcomes, and PTGS2 (COX2), a gene associated with the protective effect of aspirin in the colorectal cancer setting.	Aspirin	220-227	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	165-169
34760889-0	2021	Iguratimod Alleviates Myocardial Ischemia/Reperfusion Injury Through Inhibiting Inflammatory Response Induced by Cardiac Fibroblast Pyroptosis via COX2/NLRP3 Signaling Pathway.	iguratimod	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-151
34759823-9	2021	In addition, those representative constituents with good affinity on Topo I, Topo II, COX-2, or ACE2, such as diphyllin, podophyllotoxin, and diphyllin O-glucoside, were further validated with molecular docking analysis.	diphyllin	110-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-91
34759823-9	2021	In addition, those representative constituents with good affinity on Topo I, Topo II, COX-2, or ACE2, such as diphyllin, podophyllotoxin, and diphyllin O-glucoside, were further validated with molecular docking analysis.	Podophyllotoxin	121-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-91
34759823-9	2021	In addition, those representative constituents with good affinity on Topo I, Topo II, COX-2, or ACE2, such as diphyllin, podophyllotoxin, and diphyllin O-glucoside, were further validated with molecular docking analysis.	Cleistanthin B	142-163	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-91
34725544-10	2021	The results demonstrated that overexpression of miR-139-5p effectively repressed HG-activated inflammation, as indicated by the upregulation of inflammation cytokines, including TNF-alpha, IL-6, and Cox-2, in ARPE-19 cells.	mir-139-5p	48-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	199-204
34685328-1	2021	In the current study, a variety of sulfonated polyethersulfone (SPES)-based ion-exchange membranes were prepared and utilized as efficient and selective solid adsorbents for the detection of Co(II) ions in aquatic solutions.	sulfonated polyethersulfone	35-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	191-197
34609879-2	2021	On the basis of the ligand and the structure of the Co(II) precursor, (CoII(12-TBC)(CF3SO3)2), one would assume that this species corresponds to a tetragonal Co(IV)-oxo complex, but the spectroscopic data do not support this notion.	coii(12-tbc)(cf3so3)2	71-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-58
34609879-2	2021	On the basis of the ligand and the structure of the Co(II) precursor, (CoII(12-TBC)(CF3SO3)2), one would assume that this species corresponds to a tetragonal Co(IV)-oxo complex, but the spectroscopic data do not support this notion.	co(iv)	158-164	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-58
34609879-2	2021	On the basis of the ligand and the structure of the Co(II) precursor, (CoII(12-TBC)(CF3SO3)2), one would assume that this species corresponds to a tetragonal Co(IV)-oxo complex, but the spectroscopic data do not support this notion.	potassium oxonate	165-168	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-58
34609879-3	2021	Co K-edge XAS data show that the treatment of the Co(II) precursor with iodosylbenzene (PhIO) as an oxidant at -40  C in the presence of a proton source leads to a distinct shift in the Co K-edge, in agreement with the formation of a Co(IV) intermediate.	iodosobenzene	72-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-56
34609879-3	2021	Co K-edge XAS data show that the treatment of the Co(II) precursor with iodosylbenzene (PhIO) as an oxidant at -40  C in the presence of a proton source leads to a distinct shift in the Co K-edge, in agreement with the formation of a Co(IV) intermediate.	phio	88-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-56
34822668-6	2021	In this study, the production of proinflammatory mediators, such as nitrogen oxide and prostaglandin E2, was induced by 1-NP in a concentration-dependent manner through the expression of iNOS and COX2.	Nitrogen	68-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	196-200
34822668-6	2021	In this study, the production of proinflammatory mediators, such as nitrogen oxide and prostaglandin E2, was induced by 1-NP in a concentration-dependent manner through the expression of iNOS and COX2.	Dinoprostone	87-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	196-200
34822668-6	2021	In this study, the production of proinflammatory mediators, such as nitrogen oxide and prostaglandin E2, was induced by 1-NP in a concentration-dependent manner through the expression of iNOS and COX2.	1-nitropyrene	120-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	196-200
34435722-1	2021	An unprecedented enantioselective synthesis of spiro-gamma-lactams via a sequential C-H olefination/asymmetric (4+1) spirocyclization under a simple Co(II)/chiral spiro phosphoric acid (SPA) binary system is reported.	spiro-gamma-lactams	47-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	149-155
34435722-1	2021	An unprecedented enantioselective synthesis of spiro-gamma-lactams via a sequential C-H olefination/asymmetric (4+1) spirocyclization under a simple Co(II)/chiral spiro phosphoric acid (SPA) binary system is reported.	spiro phosphoric acid	163-184	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	149-155
34435722-1	2021	An unprecedented enantioselective synthesis of spiro-gamma-lactams via a sequential C-H olefination/asymmetric (4+1) spirocyclization under a simple Co(II)/chiral spiro phosphoric acid (SPA) binary system is reported.	spa)	186-190	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	149-155
34685328-1	2021	In the current study, a variety of sulfonated polyethersulfone (SPES)-based ion-exchange membranes were prepared and utilized as efficient and selective solid adsorbents for the detection of Co(II) ions in aquatic solutions.	spes	64-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	191-197
34721382-8	2021	Further, blocking the skin inflammation with celecoxib reveals that the acquired fate of macrophages in the KO skin is dependent on its interaction with the epidermal compartment through COX2 dependent cytokine production.	Celecoxib	45-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	187-191
34329104-7	2021	Moreover, the damaged chemical structure of CoO during PMS activation could be healed by the photo-actuated Co(II) regeneration to allow for continuous and stable catalytic process.	carboxyl radical	44-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-114
34519734-0	2021	Field-induced single-ion magnet based on a quasi-octahedral Co(II) complex with mixed sulfur-oxygen coordination environment.	Sulfur	86-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-66
34519734-0	2021	Field-induced single-ion magnet based on a quasi-octahedral Co(II) complex with mixed sulfur-oxygen coordination environment.	Oxygen	93-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-66
34519734-2	2021	X-ray diffraction studies reveal the first coordination sphere of the Co(II) ion, consisting of two chelating tridentate TDA ligands with a mixed sulfur-oxygen strongly elongated octahedral coordination environment.	Sulfur	146-152	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-76
34519734-2	2021	X-ray diffraction studies reveal the first coordination sphere of the Co(II) ion, consisting of two chelating tridentate TDA ligands with a mixed sulfur-oxygen strongly elongated octahedral coordination environment.	Oxygen	153-159	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-76
34077833-0	2021	New nimesulide derivatives with amide/sulfonamide moieties: Selective COX-2 inhibition and antitumor effects.	nimesulide	4-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-75
34216690-8	2021	AGR2 knockdown enhances therapeutic effects of a COX-2 inhibitor, celecoxib, in CRC metastasis.	Celecoxib	66-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-54
34617230-5	2022	Results show that China"s industry could ideally reduce CO2 emissions by a further 22.01-33.27%, averaging 1645.96 MtCO2.	Carbon Dioxide	56-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-120
34077833-0	2021	New nimesulide derivatives with amide/sulfonamide moieties: Selective COX-2 inhibition and antitumor effects.	Amides	32-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-75
34077833-2	2021	Experimental analyses showed that among seventeen compounds, N8 and N10 have remarkable potency and selectivity for the COX-2 enzyme over COX-1 at very low doses as compared to nimesulide.	nimesulide	177-187	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-125
34077833-3	2021	Moreover, both N8 and N10 selectively reduced the Lipopolysaccharide (LPS)-stimulated COX-2 mRNA expression level while the COX-1 level remained stable.	Nonoxynol-8	15-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-91
34607550-0	2022	Antitumor activity of zinc nanoparticles synthesized with berberine on human epithelial colorectal adenocarcinoma (Caco-2) cells through acting on Cox-2/NF-kB and p53 pathways.	Berberine	58-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-152
34631154-1	2022	We describe the total flow synthesis of the widely prescribed anti-inflammatory COX-2 inhibitor Celecoxib from 2-bromo-3,3,3-trifluoropropene, as a convenient and available trifluoromethyl building block, to generate trifluoropropynyl lithium and to trap it immediately with an aldehyde.	Celecoxib	96-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-85
34631154-1	2022	We describe the total flow synthesis of the widely prescribed anti-inflammatory COX-2 inhibitor Celecoxib from 2-bromo-3,3,3-trifluoropropene, as a convenient and available trifluoromethyl building block, to generate trifluoropropynyl lithium and to trap it immediately with an aldehyde.	2-Bromo-3,3,3-trifluoropropene	111-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-85
34607550-12	2022	In addition, green synthesis of ZnNPs with BER showed notable induction of Cox2 and NF-kB in Caco-2 cells.	znnps	32-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-79
34631154-1	2022	We describe the total flow synthesis of the widely prescribed anti-inflammatory COX-2 inhibitor Celecoxib from 2-bromo-3,3,3-trifluoropropene, as a convenient and available trifluoromethyl building block, to generate trifluoropropynyl lithium and to trap it immediately with an aldehyde.	3-trifluoromethylpyridine	173-188	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-85
34639036-4	2021	To further validate the interactions of promising compound tomatidine, Molecular dynamics study of 100 ns was carried out towards 3CLpro, NSP15 and COX-2.	tomatidine	59-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	148-153
34631154-1	2022	We describe the total flow synthesis of the widely prescribed anti-inflammatory COX-2 inhibitor Celecoxib from 2-bromo-3,3,3-trifluoropropene, as a convenient and available trifluoromethyl building block, to generate trifluoropropynyl lithium and to trap it immediately with an aldehyde.	trifluoropropynyl lithium	217-242	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-85
34631154-1	2022	We describe the total flow synthesis of the widely prescribed anti-inflammatory COX-2 inhibitor Celecoxib from 2-bromo-3,3,3-trifluoropropene, as a convenient and available trifluoromethyl building block, to generate trifluoropropynyl lithium and to trap it immediately with an aldehyde.	Aldehydes	278-286	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-85
34641564-0	2021	Crystal Structure and Magnetic Properties of Trinuclear Transition Metal Complexes (MnII, CoII, NiII and CuII) with Bridging Sulfonate-Functionalized 1,2,4-Triazole Derivatives.	Metals	67-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-94
34641564-0	2021	Crystal Structure and Magnetic Properties of Trinuclear Transition Metal Complexes (MnII, CoII, NiII and CuII) with Bridging Sulfonate-Functionalized 1,2,4-Triazole Derivatives.	Alkanesulfonates	125-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-94
34641564-0	2021	Crystal Structure and Magnetic Properties of Trinuclear Transition Metal Complexes (MnII, CoII, NiII and CuII) with Bridging Sulfonate-Functionalized 1,2,4-Triazole Derivatives.	1,2,4-triazole	150-164	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-94
34641564-1	2021	Here we present the synthesis, structure and magnetic properties of complexes of general formula (Mn)(Me2NH2)4)(Mn3(mu-L)6(H2O)6) and (Me2NH2)6(M3(mu-L)6(H2O)6) (M = CoII, NiII and CuII); L-2 = 4-(1,2,4-triazol-4-yl) ethanedisulfonate).	mn)(me2nh2)	98-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	166-170
34641564-1	2021	Here we present the synthesis, structure and magnetic properties of complexes of general formula (Mn)(Me2NH2)4)(Mn3(mu-L)6(H2O)6) and (Me2NH2)6(M3(mu-L)6(H2O)6) (M = CoII, NiII and CuII); L-2 = 4-(1,2,4-triazol-4-yl) ethanedisulfonate).	(me2nh2)	134-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	166-170
34641564-1	2021	Here we present the synthesis, structure and magnetic properties of complexes of general formula (Mn)(Me2NH2)4)(Mn3(mu-L)6(H2O)6) and (Me2NH2)6(M3(mu-L)6(H2O)6) (M = CoII, NiII and CuII); L-2 = 4-(1,2,4-triazol-4-yl) ethanedisulfonate).	Water	154-157	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	166-170
34711017-7	2021	RESULTS: CCH caused concentration and time-dependent reduction in the viability of human HepG2 and MCF7 cells, pre-G1 apoptosis and cell cycle arrest at G2/M stage, significantly higher P53 and TNF-alpha mRNA and protein expression levels but significantly lower COX2 mRNA and protein expression levels.	1-acetyl-2-(coumariniminecarboxamide-3-yl)hydrazine	9-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	263-267
34303896-6	2021	Compounds 5a-d and 5g displayed inhibitory activity against COX-2 nearly equal to Celecoxib with high selectivity index (SI).	Celecoxib	82-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-65
34400127-4	2021	COX-2 is a neuronal enzyme that is intensively produced during activation of the synapse and glutamate (Glu) release.	Glutamic Acid	93-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
34400127-4	2021	COX-2 is a neuronal enzyme that is intensively produced during activation of the synapse and glutamate (Glu) release.	Glutamic Acid	104-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
34400127-5	2021	The end product of COX-2 action, prostaglandin E2 (PGE2), regulates Glu level in a retrograde manner.	Dinoprostone	33-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-24
34400127-5	2021	The end product of COX-2 action, prostaglandin E2 (PGE2), regulates Glu level in a retrograde manner.	Dinoprostone	51-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-24
34400127-5	2021	The end product of COX-2 action, prostaglandin E2 (PGE2), regulates Glu level in a retrograde manner.	Glutamic Acid	68-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-24
34400127-8	2021	So far, the interaction between ionotropic N-methyl-D-aspartate (NMDA) receptors or metabotropic glutamate (mGluRs) receptors and COX-2 was found.	N-Methylaspartate	43-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	130-135
34400127-8	2021	So far, the interaction between ionotropic N-methyl-D-aspartate (NMDA) receptors or metabotropic glutamate (mGluRs) receptors and COX-2 was found.	N-Methylaspartate	65-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	130-135
34400127-8	2021	So far, the interaction between ionotropic N-methyl-D-aspartate (NMDA) receptors or metabotropic glutamate (mGluRs) receptors and COX-2 was found.	Glutamic Acid	97-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	130-135
34303896-5	2021	Consequently, the aim of the present investigation was to combat CRC by synthesis and biological evaluation of new thymol - 4-thiazolidinone hybrids as multitarget anticancer agents that could inhibit the key COX-2, 5-LOX and PIM-1 kinase enzymes simultaneously.	thymol - 4-thiazolidinone	115-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	209-214
34302591-9	2021	Upon PCR analysis venlafaxine remarkably turndown the mRNA expression of TNF-alpha, IL-6, IL-1beta, and COX-2.	Venlafaxine Hydrochloride	18-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
34308732-7	2021	Quercetin decreased the production of IL-1beta, IL-6, IL-8, TNF-alpha, iNOS, and COX-2, as well as signal transduction via the Akt/AMPK/mTOR pathway.	Quercetin	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-86
34302591-0	2021	Venlafaxine demonstrated anti-arthritic activity possibly through down regulation of TNF-alpha, IL-6, IL-1beta, and COX-2.	Venlafaxine Hydrochloride	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-121
34465434-2	2021	They were applied to the flocculation removal of Cr(III), Co(II), and Pb(II).	tris(1,10-phenanthroline)chromium(III) chloride	49-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-64
34464118-0	2021	Novel Nonradical Oxidation of Sulfonamide Antibiotics with Co(II)-Doped g-C3N4-Activated Peracetic Acid: Role of High-Valent Cobalt-Oxo Species.	Sulfonamides	30-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
34681084-3	2021	We reported that both models are able to induce pro-tumoral M2-like macrophage polarization, through the activation of the COX2-PGE2 axis.	Dinoprostone	128-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-127
34572149-6	2021	In this study, palmitate markedly synergizes the IL-26-induced proinflammatory effects and matrix protease, including COX-2, IL-6, and MMP-1, in HACs via the toll-like receptor 4 (TLR4)-ERK1/2-c-Jun signal transduction pathway.	Palmitates	15-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-123
34572149-8	2021	In addition, metformin, a potential inhibitor of TLR4, also decreased expression of COX-2 and IL-6 induced by co-incubation with IL-26 and palmitate.	Metformin	13-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-89
34572149-8	2021	In addition, metformin, a potential inhibitor of TLR4, also decreased expression of COX-2 and IL-6 induced by co-incubation with IL-26 and palmitate.	Palmitates	139-148	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-89
34252545-3	2021	We demonstrated that diosgenin suppressed COX-2 in human non-small-cell lung carcinoma A549 cells via nuclear factor-kappa B (NF-kappaB) translocation and the effects were reversed by a glucocorticoid receptor antagonist, RU486.	Diosgenin	21-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47
34252545-3	2021	We demonstrated that diosgenin suppressed COX-2 in human non-small-cell lung carcinoma A549 cells via nuclear factor-kappa B (NF-kappaB) translocation and the effects were reversed by a glucocorticoid receptor antagonist, RU486.	Mifepristone	222-227	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47
34680642-4	2021	LPS increased the expression levels of iNOS, Cox-2, and 4-hydroxylnonenal; however, these levels were attenuated by AE-GBE treatment.	ae-gbe	116-122	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-50
34464118-0	2021	Novel Nonradical Oxidation of Sulfonamide Antibiotics with Co(II)-Doped g-C3N4-Activated Peracetic Acid: Role of High-Valent Cobalt-Oxo Species.	Peracetic Acid	89-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
34464118-0	2021	Novel Nonradical Oxidation of Sulfonamide Antibiotics with Co(II)-Doped g-C3N4-Activated Peracetic Acid: Role of High-Valent Cobalt-Oxo Species.	cobalt-oxo	125-135	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
34464118-1	2021	Herein, we report that Co(II)-doped g-C3N4 can efficiently trigger peracetic acid (PAA) oxidation of various sulfonamides (SAs) in a wide pH range.	Peracetic Acid	67-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-29
34464118-1	2021	Herein, we report that Co(II)-doped g-C3N4 can efficiently trigger peracetic acid (PAA) oxidation of various sulfonamides (SAs) in a wide pH range.	Peracetic Acid	83-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-29
34464118-1	2021	Herein, we report that Co(II)-doped g-C3N4 can efficiently trigger peracetic acid (PAA) oxidation of various sulfonamides (SAs) in a wide pH range.	Sulfonamides	109-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-29
34464118-1	2021	Herein, we report that Co(II)-doped g-C3N4 can efficiently trigger peracetic acid (PAA) oxidation of various sulfonamides (SAs) in a wide pH range.	Sulfonamides	123-126	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-29
34464118-3	2021	Our experiments and density functional theory calculations indicate that the Co atom fixated into the nitrogen pots of g-C3N4 serves as the main active site, enabling dissociation of the adsorbed PAA and conversion of the coordinated Co(II) to Co(IV) via a unique two-electron transfer mechanism.	Cobalt	77-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	234-240
34464118-3	2021	Our experiments and density functional theory calculations indicate that the Co atom fixated into the nitrogen pots of g-C3N4 serves as the main active site, enabling dissociation of the adsorbed PAA and conversion of the coordinated Co(II) to Co(IV) via a unique two-electron transfer mechanism.	Nitrogen	102-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	234-240
34464118-3	2021	Our experiments and density functional theory calculations indicate that the Co atom fixated into the nitrogen pots of g-C3N4 serves as the main active site, enabling dissociation of the adsorbed PAA and conversion of the coordinated Co(II) to Co(IV) via a unique two-electron transfer mechanism.	co(iv)	244-250	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	234-240
34535685-0	2021	Iminodibenzyl induced redirected COX-2 activity inhibits breast cancer progression.	dibenzylamine	0-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-38
34297556-4	2021	Using spectro-electrochemical studies in conjunction with quantum chemical calculations, we identified two precatalytic intermediates formed upon the addition of two electrons and one proton to (CoII(Mabiq)(THF))(PF6) (CoMbq).	combq	219-224	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	195-199
34494829-3	2021	Cobalt-dioxolene complexes can exhibit thermally induced valence tautomeric switching between low-spin CoIII-catecholate and high-spin CoII-semiquinonate forms, where the half-temperature (T1/2) is the temperature at which there are equal amounts of the two tautomers.	cobalt-dioxolene	0-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-139
34535685-8	2021	From in vitro and in vivo studies, we concluded that Iminodibenzyl could reprogram COX-2 induced DGLA peroxidation to produce anti-cancer activity.	dibenzylamine	53-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
34535685-8	2021	From in vitro and in vivo studies, we concluded that Iminodibenzyl could reprogram COX-2 induced DGLA peroxidation to produce anti-cancer activity.	8,11,14-Eicosatrienoic Acid	97-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
34514981-7	2022	To this end, of the generation of non-steroidal anti-inflammatory drugs from "coxibs", celecoxib is the only potent selective COX-2 inhibitor that is still commercially available.	Celecoxib	87-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-131
34577066-1	2021	New magnetic metal complexes with organic radical ligands, (M(hfac)2(PyBTM)2) (M = NiII, CoII; hfac = hexafluoroacetylacetonato, PyBTM = (3,5-dichloro-4-pyridyl)bis(2,4,6-trichlorophenyl)methyl radical), were prepared and their crystal structures, magnetic properties, and electronic structures were investigated.	Metals	13-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-93
34577066-1	2021	New magnetic metal complexes with organic radical ligands, (M(hfac)2(PyBTM)2) (M = NiII, CoII; hfac = hexafluoroacetylacetonato, PyBTM = (3,5-dichloro-4-pyridyl)bis(2,4,6-trichlorophenyl)methyl radical), were prepared and their crystal structures, magnetic properties, and electronic structures were investigated.	(m(hfac)2(pybtm)2	59-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-93
34265624-7	2021	In comparison, OEA and PEA attenuated the TLR3-induced hyperthermia, although only OEA attenuated the expression of hyperthermia-related genes (IL-1beta, iNOS, COX2 and m-PGES) in the hypothalamus.	oleoylethanolamide	83-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	160-164
34514981-8	2022	Thus, the compound celecoxib became a commercial prototype inhibitor for the development of anti-inflammatory agents for COX-2 enzyme.	Celecoxib	19-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-126
34423965-1	2021	Herein, a Co(II) heteroatom metal-organic framework was successfully post-modified via unsaturated coordinated S precisely capturing Ni2+ on the surface of the porous structure.	Nickel(2+)	133-137	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-16
34515013-7	2022	RESULTS: Artemisinin treatment significantly decreased the expression levels of COX2 and COX7A2 and increased that of COX14, YEM1l1, ALAS1, and OAT after 48h.	artemisinin	9-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-84
34566947-18	2021	Levels of inflammatory mediators, including GM-CSF, VEGF, COX-2, TSLP, and IL-33 were reduced by treatment of GB88 or SBTI.	GB88	110-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
34243072-0	2021	Enhancing the tumor cell selectivity of a rhodamine-decorated iridium(III) complex by conjugating with indomethacin for COX-2 targeted photodynamic therapy.	Rhodamines	42-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-125
34110482-8	2021	BEPS showed a promising COX-2 inhibitory effect in comparison with the reference drug celecoxib.	Celecoxib	86-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
34376046-1	2021	A Co(II)-catalyzed cycloaddition reaction of alkynyl ketones and 2-acetylpyridines using 2,2"-bipyridine as the ligand has been developed.	alkynyl ketones	45-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	2-8
34376046-1	2021	A Co(II)-catalyzed cycloaddition reaction of alkynyl ketones and 2-acetylpyridines using 2,2"-bipyridine as the ligand has been developed.	2-acetylpyridine	65-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	2-8
34376046-1	2021	A Co(II)-catalyzed cycloaddition reaction of alkynyl ketones and 2-acetylpyridines using 2,2"-bipyridine as the ligand has been developed.	2,2'-Dipyridyl	89-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	2-8
34410507-7	2021	Results showed that L-cys decreased levels of inflammatory markers, mast cells, levels of COX-2, iNOS and increased levels of antioxidants markers and H2S when compared to the group 5-FU (p < 0.005).	Cysteine	20-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-95
34198048-5	2021	Moreover, through modulation of a number of proteins such as NF-kB, PARP, STAT3, Bax, Bcl-2, COX2, and cytokines, quercetin has beneficial effects in neurodegenerative disorders, liver diseases and diabetes.	Quercetin	114-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-97
34217978-4	2021	The mechanism of cytotoxicity of Sonapatha was determined at the molecular level by estimation of caspase 8 and 3 activities and Western blot analysis of NF-kappaB, COX-2, Nrf2, and RASSF7 which are overexpressed in neoplastic cells.	sonapatha	33-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	165-170
34243072-0	2021	Enhancing the tumor cell selectivity of a rhodamine-decorated iridium(III) complex by conjugating with indomethacin for COX-2 targeted photodynamic therapy.	iridium(iii)	62-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-125
34217978-6	2021	Ethanol extract of Sonapatha (0, 20, 40, and 80 mug/mL) reduced clonogenicity, increased DNA fragmentation, apoptotic and necrotic indices, lactate dehydrogenase release, caspase 8 and 3 activities and inhibited the overexpression of NF-kappaB, COX-2, Nrf2, and RASSF7 in HeLa cells concentration-dependently.	Ethanol	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	245-250
34217978-6	2021	Ethanol extract of Sonapatha (0, 20, 40, and 80 mug/mL) reduced clonogenicity, increased DNA fragmentation, apoptotic and necrotic indices, lactate dehydrogenase release, caspase 8 and 3 activities and inhibited the overexpression of NF-kappaB, COX-2, Nrf2, and RASSF7 in HeLa cells concentration-dependently.	sonapatha	19-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	245-250
34243072-0	2021	Enhancing the tumor cell selectivity of a rhodamine-decorated iridium(III) complex by conjugating with indomethacin for COX-2 targeted photodynamic therapy.	Indomethacin	103-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-125
34243075-0	2021	Optimization of pyrazole-based compounds with 1,2,4-triazole-3-thiol moiety as selective COX-2 inhibitors cardioprotective drug candidates: Design, synthesis, cyclooxygenase inhibition, anti-inflammatory, ulcerogenicity, cardiovascular evaluation, and molecular modeling studies.	pyrazole	16-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-94
34243075-0	2021	Optimization of pyrazole-based compounds with 1,2,4-triazole-3-thiol moiety as selective COX-2 inhibitors cardioprotective drug candidates: Design, synthesis, cyclooxygenase inhibition, anti-inflammatory, ulcerogenicity, cardiovascular evaluation, and molecular modeling studies.	1H-1,2,4-Triazole-3-thiol	46-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-94
34243075-2	2021	Therefore, the design of new series of pyrazole (4a,b 5a,b, 7a,b, 9a,b, 10a-h, and 11a-f) substituted with a triazole moiety as selective COX-2 inhibitors with cardioprotective effect was aimed in this paper.	pyrazole	39-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	138-143
34243075-2	2021	Therefore, the design of new series of pyrazole (4a,b 5a,b, 7a,b, 9a,b, 10a-h, and 11a-f) substituted with a triazole moiety as selective COX-2 inhibitors with cardioprotective effect was aimed in this paper.	Triazoles	109-117	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	138-143
34076332-6	2021	Furthermore ELISA and real time PCR reaction determined that brucine were down regulated inflammatory (TNF-alpha, NF-kB, IL-6 & COX-2) cell proliferation (Cyclin D1) and apoptotic marker Bax, caspase-3, PI3K (phosphoinosital 3 kinase), AKT, mTOR (mammalian target of rapamycin) and over expression Bcl-2, associated death promoter.	brucine	61-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	128-133
34392440-0	2021	Ursodeoxycholic acid shows antineoplastic effects in bile duct cancer cells via apoptosis induction; p53 activation; and EGFR-ERK, COX-2, and PI3K-AKT pathway inhibition.	Ursodeoxycholic Acid	0-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-136
34584744-1	2021	In this work, the magnetic anisotropy in two iso-structural distorted tetrahedral Co(II) complexes, CoX 2tmtu2 (X = Cl(1) and Br(2), tmtu = tetra-methyl-thio-urea) is investigated, using a combination of polarized neutron diffraction (PND), very low-temperature high-resolution synchrotron X-ray diffraction and CASSCF/NEVPT2 ab initio calculations.	Bromine	126-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-88
34584744-1	2021	In this work, the magnetic anisotropy in two iso-structural distorted tetrahedral Co(II) complexes, CoX 2tmtu2 (X = Cl(1) and Br(2), tmtu = tetra-methyl-thio-urea) is investigated, using a combination of polarized neutron diffraction (PND), very low-temperature high-resolution synchrotron X-ray diffraction and CASSCF/NEVPT2 ab initio calculations.	Urea	158-162	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-88
34091174-1	2021	Our earlier studies show that the peroxidase activity of cyclooxygenase 1 and 2 (COX-1 and COX-2) can be reactivated in vitro and in vivo by the presence of certain naturally-occurring flavonoids such as quercetin and myricetin, which serve as reducing cosubstrates.	Flavonoids	185-195	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-96
34091174-1	2021	Our earlier studies show that the peroxidase activity of cyclooxygenase 1 and 2 (COX-1 and COX-2) can be reactivated in vitro and in vivo by the presence of certain naturally-occurring flavonoids such as quercetin and myricetin, which serve as reducing cosubstrates.	Quercetin	204-213	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-96
34091174-1	2021	Our earlier studies show that the peroxidase activity of cyclooxygenase 1 and 2 (COX-1 and COX-2) can be reactivated in vitro and in vivo by the presence of certain naturally-occurring flavonoids such as quercetin and myricetin, which serve as reducing cosubstrates.	myricetin	218-227	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-96
34091174-3	2021	In the present study, quercetin is used as a representative model compound to investigate the chemical mechanism by which the peroxidase activity of human COX-1 and COX-2 is reactivated after each catalytic cycle.	Quercetin	22-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	165-170
34900302-9	2021	Thermogravimetric analysis indicates thermo-stability of the adsorbent up to 300  C. Optimal conditions for adsorption were determined as pH = 6.5 and contact time = 1 h. The adsorption capacities of TEPA-MIL-101(Cr) for Pb(II), Cu(II), Cd(II), and Co(II) from aqueous samples were 227.5, 217.7, 221.4, and 215.6 mg/g respectively, which is on average more than 8 times that of MIL-101(Cr).	tetraethylenepentamine	200-204	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	249-255
34900302-9	2021	Thermogravimetric analysis indicates thermo-stability of the adsorbent up to 300  C. Optimal conditions for adsorption were determined as pH = 6.5 and contact time = 1 h. The adsorption capacities of TEPA-MIL-101(Cr) for Pb(II), Cu(II), Cd(II), and Co(II) from aqueous samples were 227.5, 217.7, 221.4, and 215.6 mg/g respectively, which is on average more than 8 times that of MIL-101(Cr).	MIL-101	378-385	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	249-255
34900302-9	2021	Thermogravimetric analysis indicates thermo-stability of the adsorbent up to 300  C. Optimal conditions for adsorption were determined as pH = 6.5 and contact time = 1 h. The adsorption capacities of TEPA-MIL-101(Cr) for Pb(II), Cu(II), Cd(II), and Co(II) from aqueous samples were 227.5, 217.7, 221.4, and 215.6 mg/g respectively, which is on average more than 8 times that of MIL-101(Cr).	Chromium	386-389	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	249-255
34392440-2	2021	Aim of this study was to demonstrate whether UDCA actually inhibits proliferation and induces apoptosis in bile duct cancer cells; the effect of UDCA on the expression of COX-2, PI3K/AKT, ERK, and EGFR; how UDCA affects cancer cell invasiveness and metastasis, since these effects are not established in bile duct cancer cells.	Ursodeoxycholic Acid	145-149	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	171-176
34392440-8	2021	In cultured bile duct cancer cells, UDCA suppressed cell proliferation in bile duct cancer cells by inducing apoptosis and p53 activation, blocking deoxycholic acid (DCA)-induced activated EGFR-ERK signaling and COX-2, inhibiting DCA-induced activated PI3K-AKT signaling, and suppressing the invasiveness of bile duct cancer cells.	Ursodeoxycholic Acid	36-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	212-217
34392440-8	2021	In cultured bile duct cancer cells, UDCA suppressed cell proliferation in bile duct cancer cells by inducing apoptosis and p53 activation, blocking deoxycholic acid (DCA)-induced activated EGFR-ERK signaling and COX-2, inhibiting DCA-induced activated PI3K-AKT signaling, and suppressing the invasiveness of bile duct cancer cells.	Deoxycholic Acid	148-164	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	212-217
34392440-8	2021	In cultured bile duct cancer cells, UDCA suppressed cell proliferation in bile duct cancer cells by inducing apoptosis and p53 activation, blocking deoxycholic acid (DCA)-induced activated EGFR-ERK signaling and COX-2, inhibiting DCA-induced activated PI3K-AKT signaling, and suppressing the invasiveness of bile duct cancer cells.	Deoxycholic Acid	166-169	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	212-217
34125438-12	2021	A reduction was observed in the frequency of PHH3 and Cox2 markers in the prostatic epithelium of TBCP in comparison with T. A decrease in F4/80 and CD163 positive macrophages were also observed in the prostatic stroma of the TBCP group in comparison with T. The results suggest that BCP had favorable effects on BPH, reducing the proliferation and frequency of some inflammatory cells.	tbcp	98-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-58
34288015-20	2021	By immunohistochemistry, COX1 was predominantly observed in the prostatic stroma while COX2 was present in scattered luminal cells of isolated prostatic glands in S-BPH.	Phenobarbital	117-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-91
34125438-12	2021	A reduction was observed in the frequency of PHH3 and Cox2 markers in the prostatic epithelium of TBCP in comparison with T. A decrease in F4/80 and CD163 positive macrophages were also observed in the prostatic stroma of the TBCP group in comparison with T. The results suggest that BCP had favorable effects on BPH, reducing the proliferation and frequency of some inflammatory cells.	tbcp	226-230	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-58
34125438-12	2021	A reduction was observed in the frequency of PHH3 and Cox2 markers in the prostatic epithelium of TBCP in comparison with T. A decrease in F4/80 and CD163 positive macrophages were also observed in the prostatic stroma of the TBCP group in comparison with T. The results suggest that BCP had favorable effects on BPH, reducing the proliferation and frequency of some inflammatory cells.	caryophyllene	284-287	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-58
34246991-3	2021	In this study, we systematically investigated the performance and mechanism of degradation of phosphonates in Co(II)-triggered peroxymonosulfate (PMS) activation process.	peroxymonosulfate	127-144	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-116
34466065-9	2021	Dieckol also regulated the proliferative (cyclin D1), inflammatory (COX-2, IL-6, TNF-alpha, and NF-kappaB), and apoptotic (caspase-3, Bax, Bcl-2) markers in the MG-63 cells.	dieckol	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-73
34246991-3	2021	In this study, we systematically investigated the performance and mechanism of degradation of phosphonates in Co(II)-triggered peroxymonosulfate (PMS) activation process.	peroxymonosulfate	146-149	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-116
34246991-0	2021	Degradation of phosphonates in Co(II)/peroxymonosulfate process: Performance and mechanism.	Organophosphonates	15-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-37
34246991-4	2021	The degradation efficiency of various phosphonates is highly dependent on their coordination with Co(II).	Organophosphonates	38-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-104
34246991-0	2021	Degradation of phosphonates in Co(II)/peroxymonosulfate process: Performance and mechanism.	peroxymonosulfate	38-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-37
34246991-5	2021	Using 1-hydroxyethane 1,1-diphosphonic acid (HEDP) as a target pollutant, the Co(II)/PMS process is effective in a broad solution pH range from 5.0 to 10.0.	Etidronic Acid	6-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-84
34246991-3	2021	In this study, we systematically investigated the performance and mechanism of degradation of phosphonates in Co(II)-triggered peroxymonosulfate (PMS) activation process.	Organophosphonates	94-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-116
34246991-5	2021	Using 1-hydroxyethane 1,1-diphosphonic acid (HEDP) as a target pollutant, the Co(II)/PMS process is effective in a broad solution pH range from 5.0 to 10.0.	Etidronic Acid	45-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-84
34246991-5	2021	Using 1-hydroxyethane 1,1-diphosphonic acid (HEDP) as a target pollutant, the Co(II)/PMS process is effective in a broad solution pH range from 5.0 to 10.0.	peroxymonosulfate	85-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-84
34465013-2	2022	Enzymes involved in the metabolism of PGE2 include cyclooxygenase (COX)-2, microsomal prostaglandin E synthase-1 (mPGES-1), and 15-prostaglandin dehydrogenase (15-PGDH).	Dinoprostone	38-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-73
34465013-11	2022	Conclusion: These results demonstrated that PGE2 can be induced by stimuli such as TNF-alpha, and suggest that activation of mPGES-1 is more closely related than that of COX-2 in the induction of PGE2 on colon cancer.	Dinoprostone	44-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	170-175
34465013-11	2022	Conclusion: These results demonstrated that PGE2 can be induced by stimuli such as TNF-alpha, and suggest that activation of mPGES-1 is more closely related than that of COX-2 in the induction of PGE2 on colon cancer.	Dinoprostone	196-200	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	170-175
34246991-6	2021	Multiple experimental results imply that Co(II)-PMS complex is the primary reactive species, while hydroxyl radicals (HO ), sulfate radicals (SO4 -), singlet oxygen (1O2) and Co(III) play as the secondary reactive species for the degradation of HEDP.	peroxymonosulfate	48-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-47
34246991-6	2021	Multiple experimental results imply that Co(II)-PMS complex is the primary reactive species, while hydroxyl radicals (HO ), sulfate radicals (SO4 -), singlet oxygen (1O2) and Co(III) play as the secondary reactive species for the degradation of HEDP.	Etidronic Acid	245-249	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-47
34246991-8	2021	However, in real water samples, the selectivity and efficiency for HEDP removal in the Co(II)/PMS process are higher than that in free radicals-mediated advanced oxidation processes.	Water	17-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-93
34246991-8	2021	However, in real water samples, the selectivity and efficiency for HEDP removal in the Co(II)/PMS process are higher than that in free radicals-mediated advanced oxidation processes.	Etidronic Acid	67-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-93
34246991-8	2021	However, in real water samples, the selectivity and efficiency for HEDP removal in the Co(II)/PMS process are higher than that in free radicals-mediated advanced oxidation processes.	peroxymonosulfate	94-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-93
34246991-9	2021	This study not only sheds new lights on the mechanism of Co(II)-triggered PMS activation process, but also provides feasible technology for the degradation of phosphonates in wastewater.	Organophosphonates	159-171	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-63
34575442-4	2021	In this study, nimesulide, a cyclooxygenase (COX)-2 selective inhibitor, was conjugated with hyaluronic acid (HA), and the HA-nimesulide conjugates were expected to increase the solubility and biocompatibility for alleviating the DES in the benzalkonium chloride (BAC)-induced goblet cell-loss dry eye model.	nimesulide	15-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-51
34575442-4	2021	In this study, nimesulide, a cyclooxygenase (COX)-2 selective inhibitor, was conjugated with hyaluronic acid (HA), and the HA-nimesulide conjugates were expected to increase the solubility and biocompatibility for alleviating the DES in the benzalkonium chloride (BAC)-induced goblet cell-loss dry eye model.	Hyaluronic Acid	93-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-51
34575442-4	2021	In this study, nimesulide, a cyclooxygenase (COX)-2 selective inhibitor, was conjugated with hyaluronic acid (HA), and the HA-nimesulide conjugates were expected to increase the solubility and biocompatibility for alleviating the DES in the benzalkonium chloride (BAC)-induced goblet cell-loss dry eye model.	Hyaluronic Acid	110-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-51
34428217-6	2021	In contrast, indomethacin did not exhibit this capacity, whereas cyclooxygenase (COX)-2 selective NSAID, celecoxib, induced a similar pattern like Acetylsalicylic acid, suggesting a possible relevance of COX-2.	Celecoxib	105-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-87
34324612-0	2021	A multifunctional magnetic material based on a solid solution of Fe(II)/Co(II) complexes with a macrocyclic cyclam-based ligand.	ammonium ferrous sulfate	65-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-78
34324612-0	2021	A multifunctional magnetic material based on a solid solution of Fe(II)/Co(II) complexes with a macrocyclic cyclam-based ligand.	cyclam	108-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-78
34454603-0	2021	Pimecrolimus interferes the therapeutic efficacy of human mesenchymal stem cells in atopic dermatitis by regulating NFAT-COX2 signaling.	pimecrolimus	0-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-125
34454603-12	2021	And we demonstrated that pimecrolimus downregulated COX2-PGE2 axis by inhibiting nuclear translocation of NFAT3.	pimecrolimus	25-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-56
34454603-12	2021	And we demonstrated that pimecrolimus downregulated COX2-PGE2 axis by inhibiting nuclear translocation of NFAT3.	Dinoprostone	57-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-56
34500969-3	2021	Based on the use of the optimized syntheses parameters, the preparation of layered triple and multiple hydroxides was also attempted using Ni(II), Co(II), Zn(II) and even Mg(II) ions.	Hydroxides	103-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-153
34324612-1	2021	In order to prepare a multifunctional magnetic material combining spin crossover together with single-molecular magnetism, co-crystallization of Fe(ii) and Co(ii) complexes of the pyridine derivative of cyclam (Py2-C = 1,8-bis(pyridin-2-ylmethyl)-1,4,8,11-tetraazacyclotetradecane) was performed.	pyridine	180-188	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	156-162
34324612-1	2021	In order to prepare a multifunctional magnetic material combining spin crossover together with single-molecular magnetism, co-crystallization of Fe(ii) and Co(ii) complexes of the pyridine derivative of cyclam (Py2-C = 1,8-bis(pyridin-2-ylmethyl)-1,4,8,11-tetraazacyclotetradecane) was performed.	cyclam	203-209	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	156-162
34324612-1	2021	In order to prepare a multifunctional magnetic material combining spin crossover together with single-molecular magnetism, co-crystallization of Fe(ii) and Co(ii) complexes of the pyridine derivative of cyclam (Py2-C = 1,8-bis(pyridin-2-ylmethyl)-1,4,8,11-tetraazacyclotetradecane) was performed.	py2-c	211-216	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	156-162
34428217-6	2021	In contrast, indomethacin did not exhibit this capacity, whereas cyclooxygenase (COX)-2 selective NSAID, celecoxib, induced a similar pattern like Acetylsalicylic acid, suggesting a possible relevance of COX-2.	Aspirin	147-167	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-87
34428217-6	2021	In contrast, indomethacin did not exhibit this capacity, whereas cyclooxygenase (COX)-2 selective NSAID, celecoxib, induced a similar pattern like Acetylsalicylic acid, suggesting a possible relevance of COX-2.	Aspirin	147-167	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	204-209
34269774-1	2021	Herein we report heteroleptic Co(ii) diimine complexes (Co(H2bip)2Cl2) (1), (Co(H2bip)2Br2) (2), (Co(H2bip)3)Br2 1MeOH (3) and (Co(H2bip)2(Me2bpy))Br2 (MeCN)0.5 (H2O)0.25 (4) (H2bip = 2,2"-bi-1,4,5,6-tetrahydropyrimidine, bpy = 2,2"-dipyridyl, Me2bpy = 4,4"-Me-2,2"-dipyridyl), purposefully prepared to enable a systematic study of magnetic property changes arising from the increase of overall ligand field from sigma/pi-donor chlorido (1) to pi-acceptor 4,4"Me-2,2"bpy (4).	Water	162-165	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-36
34142447-5	2021	Therefore, the Co-MOP@COF hybrid material achieves the enhanced lithium storage mechanism involving multi-electron redox reactions, related to the Co(II) center and organic groups (C=C groups of benzene rings and C=N groups), and further the improved electrochemical performance.	Lithium	64-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-153
34142447-5	2021	Therefore, the Co-MOP@COF hybrid material achieves the enhanced lithium storage mechanism involving multi-electron redox reactions, related to the Co(II) center and organic groups (C=C groups of benzene rings and C=N groups), and further the improved electrochemical performance.	Benzene	195-202	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-153
34423968-3	2021	Herein, we demonstrate a new preparation of uniformly structural substituted cobalt iron oxides via acidic redox-assisted precipitation (ARP) upon the interaction of CoII and K2FeO4.	cobalt iron oxides	77-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	166-170
34423968-3	2021	Herein, we demonstrate a new preparation of uniformly structural substituted cobalt iron oxides via acidic redox-assisted precipitation (ARP) upon the interaction of CoII and K2FeO4.	potassium ferrate	175-181	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	166-170
34445685-4	2021	Celecoxib and GS alone or co-incubated with IL-1beta significantly reduced expression and release of cyclooxygenase (COX)-2, prostaglandin (PG)E2, IL-1beta, IL-6, tumor necrosis factor (TNF)-alpha, and MMPs, while it increased Col2a1, compared to baseline or IL-1beta.	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-123
34447267-15	2021	Conclusion: Celecoxib oral solution is a safe, effective COX-2-selective nonsteroidal anti-inflammatory drug for the treatment of acute migraine.	Celecoxib	12-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-62
34314144-1	2021	We report a new class of four dimeric Co(II) complexes (Co2(bbpen)(X)2) (H2bbpen = N,N"-bis(2-hydroxybenzyl)-N,N"-bis(2-methylpyridyl)ethylenediamine) (X- = SCN (1), Cl (2), Br (3), and I (4)) with different coordination geometry of two Co(II) centers (trigonal-prismatic and pseudo-tetrahedral) and their magnetic study.	N,N'-bis(2-hydroxybenzyl)-N,N'-bis(2-methylpyridyl) ethylenediamine	83-150	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-44
34352174-2	2021	Herein an unprecedented cobalt-catalyzed highly site-, diastereo-, and enantioselective protocol for stereoselective formation of nucleophilic allyl-Co(II) complexes followed by addition to aldehydes is presented.	Cobalt	24-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	149-155
34352174-2	2021	Herein an unprecedented cobalt-catalyzed highly site-, diastereo-, and enantioselective protocol for stereoselective formation of nucleophilic allyl-Co(II) complexes followed by addition to aldehydes is presented.	Aldehydes	190-199	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	149-155
34584766-1	2021	The asymmetric unit of the polymeric title compound {(Co2(C12H7NO8)(H2O)2) 1.6H2O} n comprises two CoII ions, which are coordinated by fully deprotonated 2-aminodi-acetic terephthalic acid (adtp4-) and terminal water mol-ecules in distorted octa-hedral N1O5 and O6 coordination environments.	Water	68-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-103
34584766-1	2021	The asymmetric unit of the polymeric title compound {(Co2(C12H7NO8)(H2O)2) 1.6H2O} n comprises two CoII ions, which are coordinated by fully deprotonated 2-aminodi-acetic terephthalic acid (adtp4-) and terminal water mol-ecules in distorted octa-hedral N1O5 and O6 coordination environments.	2-aminodi-acetic terephthalic acid	154-188	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-103
34584766-1	2021	The asymmetric unit of the polymeric title compound {(Co2(C12H7NO8)(H2O)2) 1.6H2O} n comprises two CoII ions, which are coordinated by fully deprotonated 2-aminodi-acetic terephthalic acid (adtp4-) and terminal water mol-ecules in distorted octa-hedral N1O5 and O6 coordination environments.	adtp4-	190-196	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-103
34584766-1	2021	The asymmetric unit of the polymeric title compound {(Co2(C12H7NO8)(H2O)2) 1.6H2O} n comprises two CoII ions, which are coordinated by fully deprotonated 2-aminodi-acetic terephthalic acid (adtp4-) and terminal water mol-ecules in distorted octa-hedral N1O5 and O6 coordination environments.	Water	211-216	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-103
34584766-1	2021	The asymmetric unit of the polymeric title compound {(Co2(C12H7NO8)(H2O)2) 1.6H2O} n comprises two CoII ions, which are coordinated by fully deprotonated 2-aminodi-acetic terephthalic acid (adtp4-) and terminal water mol-ecules in distorted octa-hedral N1O5 and O6 coordination environments.	octa-hedral n1o5	241-257	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-103
34584766-2	2021	The title compound features tetra-nuclear CoII units bridged by kappa 3 O:O:O"- and kappa 3 O:O,O"-carboxyl-ate groups, which are joined into ribbons via syn-anti carboxyl-ate bridges.	o,o"-carboxyl-ate	94-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-46
34584766-2	2021	The title compound features tetra-nuclear CoII units bridged by kappa 3 O:O:O"- and kappa 3 O:O,O"-carboxyl-ate groups, which are joined into ribbons via syn-anti carboxyl-ate bridges.	carboxyl-ate	163-175	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-46
34584766-3	2021	The parallel adtp4- ligands with an alternately reversed arrangement further link adjacent CoII ribbons into (010) layers, which are assembled into a three-dimensional supra-molecular network via inter-molecular hydrogen bonds.	Hydrogen	212-220	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-95
34101917-2	2021	The redox-chemistry of octahedrally-coordinated high-spin Co II complexes (three unpaired electrons) with one redox-active bisguanidine ligand and two acetylacetonato (acac) co-ligands is completely changed by replacing the acac by hexafluoro-acetylacetonato (hfacac) co-ligands.	alexidine	123-135	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
34101917-2	2021	The redox-chemistry of octahedrally-coordinated high-spin Co II complexes (three unpaired electrons) with one redox-active bisguanidine ligand and two acetylacetonato (acac) co-ligands is completely changed by replacing the acac by hexafluoro-acetylacetonato (hfacac) co-ligands.	acetylacetonato	151-166	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
34376069-4	2022	Co-therapy with aspirin reduces the GI benefits of COX-2 selective agents, whereas ibuprofen and naproxen may neglect the antiplatelet effect of aspirin.	Aspirin	16-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-56
34376069-7	2022	Celecoxib, a COX-2 selective agent, seems safer for both the upper and the lower GI tract.	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
34314144-1	2021	We report a new class of four dimeric Co(II) complexes (Co2(bbpen)(X)2) (H2bbpen = N,N"-bis(2-hydroxybenzyl)-N,N"-bis(2-methylpyridyl)ethylenediamine) (X- = SCN (1), Cl (2), Br (3), and I (4)) with different coordination geometry of two Co(II) centers (trigonal-prismatic and pseudo-tetrahedral) and their magnetic study.	cl (2)	166-172	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-44
34101917-2	2021	The redox-chemistry of octahedrally-coordinated high-spin Co II complexes (three unpaired electrons) with one redox-active bisguanidine ligand and two acetylacetonato (acac) co-ligands is completely changed by replacing the acac by hexafluoro-acetylacetonato (hfacac) co-ligands.	acetylacetone	168-172	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
34101917-2	2021	The redox-chemistry of octahedrally-coordinated high-spin Co II complexes (three unpaired electrons) with one redox-active bisguanidine ligand and two acetylacetonato (acac) co-ligands is completely changed by replacing the acac by hexafluoro-acetylacetonato (hfacac) co-ligands.	acetylacetone	224-228	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
34101917-2	2021	The redox-chemistry of octahedrally-coordinated high-spin Co II complexes (three unpaired electrons) with one redox-active bisguanidine ligand and two acetylacetonato (acac) co-ligands is completely changed by replacing the acac by hexafluoro-acetylacetonato (hfacac) co-ligands.	hexafluoro-acetylacetonato	232-258	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
34314144-1	2021	We report a new class of four dimeric Co(II) complexes (Co2(bbpen)(X)2) (H2bbpen = N,N"-bis(2-hydroxybenzyl)-N,N"-bis(2-methylpyridyl)ethylenediamine) (X- = SCN (1), Cl (2), Br (3), and I (4)) with different coordination geometry of two Co(II) centers (trigonal-prismatic and pseudo-tetrahedral) and their magnetic study.	i (4)	186-191	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-44
34101917-2	2021	The redox-chemistry of octahedrally-coordinated high-spin Co II complexes (three unpaired electrons) with one redox-active bisguanidine ligand and two acetylacetonato (acac) co-ligands is completely changed by replacing the acac by hexafluoro-acetylacetonato (hfacac) co-ligands.	hfacac	260-266	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
34101917-4	2021	By contrast, in the case of the less Lewis-basic hfacac co-ligands, the first one-electron oxidation becomes ligand-centered, leading to high-spin Co II complexes with a radical monocationic guanidine ligand unit (four unpaired electrons).	Guanidine	191-200	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-152
34389796-2	2021	However, technical limitations of in-situ prostaglandin detection in tissue have led researchers to infer prostaglandin tissue distributions from localization of regulatory synthases, such as COX1 and COX2.	Prostaglandins	106-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	201-205
34101917-6	2021	Second one-electron oxidation leads to high-spin Co II complexes with dicationic guanidine ligand units (three unpaired electrons) in the presence of hfacac co-ligands, but to low-spin Co III complexes with radical monocationic, peralkylated guanidine ligand (one unpaired electron) in the presence of acac co-ligands.	Guanidine	81-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-54
34314144-0	2021	Modulation of Magnetic Anisotropy and Exchange Interaction in Phenoxide-Bridged Dinuclear Co(II) Complexes.	phenolate	62-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-96
34314144-1	2021	We report a new class of four dimeric Co(II) complexes (Co2(bbpen)(X)2) (H2bbpen = N,N"-bis(2-hydroxybenzyl)-N,N"-bis(2-methylpyridyl)ethylenediamine) (X- = SCN (1), Cl (2), Br (3), and I (4)) with different coordination geometry of two Co(II) centers (trigonal-prismatic and pseudo-tetrahedral) and their magnetic study.	(co2(bbpen)(x)2)	55-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-44
34314144-1	2021	We report a new class of four dimeric Co(II) complexes (Co2(bbpen)(X)2) (H2bbpen = N,N"-bis(2-hydroxybenzyl)-N,N"-bis(2-methylpyridyl)ethylenediamine) (X- = SCN (1), Cl (2), Br (3), and I (4)) with different coordination geometry of two Co(II) centers (trigonal-prismatic and pseudo-tetrahedral) and their magnetic study.	h2bbpen	73-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-44
34280124-5	2021	In contrast, celecoxib, a selective COX-2 inhibitor, significantly down-regulated the expression of CD82 in decidual stromal cells (DSCs).	Celecoxib	13-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-41
34443477-3	2021	Treatment of these disks and domes with metal ions such as Fe(II), Cu(II), Zn(II), Co(II), and Ru(III) triggered the formation of microcages, and micron-sized cup-like structures.	Metals	40-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-89
34456742-14	2021	The NOS-COX pathway was significantly affected under TNZ condition, since L-Cit supplementation downregulated the mRNA expression of iNOS-COX2 in the hypothalamus, and further reduced the serum PGE2 concentration.	6-chloranyl-2-methoxy-4-phenyl-quinazoline	53-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	138-142
34456742-14	2021	The NOS-COX pathway was significantly affected under TNZ condition, since L-Cit supplementation downregulated the mRNA expression of iNOS-COX2 in the hypothalamus, and further reduced the serum PGE2 concentration.	Citrulline	74-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	138-142
34280124-10	2021	This study suggests that CD82 should be a novel promotor for decidualization under a positive regulation of the COX-2/PGE2/IL-1beta positive feedback loop.	Dinoprostone	118-122	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-117
34370644-0	2022	Design and Synthesis of Novel Ibuprofen Derivatives as Selective COX-2 inhibitors and potential anti-inflammatory agents: Evaluation of PGE2, TNF-alpha, IL-6 and histopathological study.	Ibuprofen	30-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-70
34347801-4	2021	SARS-CoV-2 induces PGE2 generation and secretion in infected lung epithelial cells by upregulating cyclo-oxygenase (COX)-2 and reducing the PG-degrading enzyme 15-hydroxyprostaglandin-dehydrogenase.	Dinoprostone	19-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-122
34370644-1	2022	BACKGROUND: The reported binding mode of ibuprofen in the COX-2 binding site indicated that the carboxylic group binds with Arg-120 and Tyr-355 at the entrance of the cyclooxygenase channel and does not extend into the pocket.	Ibuprofen	41-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
34370644-1	2022	BACKGROUND: The reported binding mode of ibuprofen in the COX-2 binding site indicated that the carboxylic group binds with Arg-120 and Tyr-355 at the entrance of the cyclooxygenase channel and does not extend into the pocket.	Arginine	124-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
34370644-1	2022	BACKGROUND: The reported binding mode of ibuprofen in the COX-2 binding site indicated that the carboxylic group binds with Arg-120 and Tyr-355 at the entrance of the cyclooxygenase channel and does not extend into the pocket.	Tyrosine	136-139	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
34443321-3	2021	The effect of BBR on AA/LPS activated proinflammatory markers including TNF-alpha, MCP-1, IL-8 and COX-2 was measured by ELISA or quantitative real-time PCR.	Berberine	14-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-104
34443321-5	2021	AA/ LPS-induced TNF-alpha, MCP-1, IL-6, IL-8, and COX-2 markers were markedly attenuated by BBR treatment in THP-1 cells by inhibiting NF-kappaB translocation into the nucleus.	Berberine	92-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-55
34292709-4	2021	The key to success is the optimization of the Co(II)-based metalloradical catalyst through judicious modulation of D2-symmetric chiral amidoporphyrin ligand to adopt proper steric, electronic, and chiral environments that can utilize a network of noncovalent attractive interactions for effective activation of the substrate and subsequent radical intermediates.	amidoporphyrin	135-149	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-52
34292709-5	2021	Supported by an optimal chiral ligand, the Co(II)-based metalloradical system, which operates under mild conditions, is capable of 1,4-C-H alkylation of alpha-aryldiazoketones with varied electronic and steric properties to construct chiral alpha,beta-disubstituted cyclobutanones in good to high yields with high diastereoselectivities and enantioselectivities, generating dinitrogen as the only byproduct.	alpha-aryldiazoketones	153-175	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-49
34292709-5	2021	Supported by an optimal chiral ligand, the Co(II)-based metalloradical system, which operates under mild conditions, is capable of 1,4-C-H alkylation of alpha-aryldiazoketones with varied electronic and steric properties to construct chiral alpha,beta-disubstituted cyclobutanones in good to high yields with high diastereoselectivities and enantioselectivities, generating dinitrogen as the only byproduct.	alpha,beta-disubstituted cyclobutanones	241-280	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-49
34292709-5	2021	Supported by an optimal chiral ligand, the Co(II)-based metalloradical system, which operates under mild conditions, is capable of 1,4-C-H alkylation of alpha-aryldiazoketones with varied electronic and steric properties to construct chiral alpha,beta-disubstituted cyclobutanones in good to high yields with high diastereoselectivities and enantioselectivities, generating dinitrogen as the only byproduct.	Nitrogen	374-384	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-49
34281344-0	2021	Synthesis, Characterization, and Catalytic Study of Amine-Bridged Bis(phenolato) Co(II) and Co(II/III)-M(I) Complexes (M = K or Na).	Amines	52-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-87
34281344-1	2021	Co(II) complexes 1-3 bearing amine-bridged bis(phenolato) complexes have been synthesized through reactions of bis(phenols) with CoCl2 or Co(OAc)2.	Amines	29-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
34291934-3	2021	Suited templates are triflate or triflimide salts of ZnII, FeII, CoII, or MnII.	triflimide	33-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-69
34281344-1	2021	Co(II) complexes 1-3 bearing amine-bridged bis(phenolato) complexes have been synthesized through reactions of bis(phenols) with CoCl2 or Co(OAc)2.	bis(phenolato)	43-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
34281344-1	2021	Co(II) complexes 1-3 bearing amine-bridged bis(phenolato) complexes have been synthesized through reactions of bis(phenols) with CoCl2 or Co(OAc)2.	bis(4-hydroxyphenyl)sulfone	111-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
34281344-1	2021	Co(II) complexes 1-3 bearing amine-bridged bis(phenolato) complexes have been synthesized through reactions of bis(phenols) with CoCl2 or Co(OAc)2.	cobaltous chloride	129-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
34281344-1	2021	Co(II) complexes 1-3 bearing amine-bridged bis(phenolato) complexes have been synthesized through reactions of bis(phenols) with CoCl2 or Co(OAc)2.	co(oac)2	138-146	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
34281344-2	2021	Oxidation of the Co(II) complex with air resulted in partial oxidation, generating mixed valence Co(II/III) complexes 4 and 5.	co(ii	97-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-23
34382871-2	2021	In this study, the effects of CYJ-27 on the regulation of inducible nitric oxide synthase (iNOS), heme oxygenase (HO)-1, and cyclooxygenase (COX-)2 were characterized in lipopolysaccharide (LPS)-treated human umbilical vein endothelial cells (HUVECs).	cyj-27	30-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	141-147
34241683-4	2021	The effect of metal-ion substitution at the second metal-binding site of DapE on its substrate affinity and catalytic efficiency is investigated by QM/MM treatment of the enzyme-substrate complex, by modelling the enzyme with Mn(II), Co(II), Ni(II), or Cu(II) ion in place of Zn(II) at its second metal-binding site, while retaining Zn(II) ion at the first metal-binding site.	1,2-diarachidonoyl-glycero-3-phosphoethanolamine	73-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	234-240
34264123-4	2021	In this review, we provide an overview of the detailed mechanism and rationale of COX-2 inhibitors as anticancer agents and we highlight the most promising research efforts on nanotechnological approaches to enhance COX-2 inhibitors delivery with special focus on celecoxib as the most widely studied agent for chemoprevention or combined with chemotherapeutic and herbal drugs for combating various cancers.	Celecoxib	264-273	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	216-221
34355287-5	2021	METHODS: The effect of curcumin and BDMC-A on transcription factors (NF-kappaB, p65, c-Jun, c-Fos, STAT3, 5, PPAR-gamma, beta-catenin, COX-2, MMP-9, VEGF, TIMP-2) involved in signal transduction cascade, invasion, and angiogenesis in Hep-2 cells were quantified using Western blotting and RT-PCR technique.	Curcumin	23-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-140
34278737-11	2021	ACT is an effective antipyretic (COX2 preference for PG synthesis) and can reduce afebrile core temperature (likely COX1 preference for PG synthesis).	Prostaglandins	53-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-37
34257723-6	2021	Additionally, metformin inhibited cyclooxygenase (COX)-2 expression.	Metformin	14-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-56
34257723-8	2021	Thus, the current data suggested that metformin may have potential value as a synergistic therapy targeting both the COX-2 and mTOR signaling pathways.	Metformin	38-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-122
34310861-3	2021	Their mechanism of action is associated with the enzymes of the arachidonic acid cycle (cyclooxygenases: COX-1 and COX-2).	Arachidonic Acid	64-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-120
34310861-9	2021	It is suggested that both COX isoforms play opposing roles in renal function, with natriuresis increased by COX-1 inhibition followed by a drop in a blood pressure, whereas COX-2 inhibition increases blood pressure and promotes sodium retention.	Sodium	228-234	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	173-178
34354342-6	2021	Moreover, anti-inflammatory mechanisms of imidazole derivatives include inhibition of COX-2 enzyme, inhibit neutrophils degranulation, and generation of reactive oxygen species.	imidazole	42-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-91
34223706-7	2021	COX-2 protein can be reduced by 300 nM P4 but this did not equate to myometrial relaxation.	propiverine	39-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
34119969-0	2021	Insights into the oxidation of organic contaminants by Co(II) activated peracetic acid: The overlooked role of high-valent cobalt-oxo species.	Peracetic Acid	72-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-61
34119969-0	2021	Insights into the oxidation of organic contaminants by Co(II) activated peracetic acid: The overlooked role of high-valent cobalt-oxo species.	cobalt-oxo	123-133	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-61
34119969-1	2021	The combination of Co(II) and peracetic acid (PAA) is a promising advanced oxidation process for the abatement of refractory organic contaminants, and acetylperoxy (CH3CO3 ) and acetoxyl (CH3CO2 ) radicals are generally recognized as the dominant and selective intermediate oxidants.	Peracetic Acid	46-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-25
34119969-1	2021	The combination of Co(II) and peracetic acid (PAA) is a promising advanced oxidation process for the abatement of refractory organic contaminants, and acetylperoxy (CH3CO3 ) and acetoxyl (CH3CO2 ) radicals are generally recognized as the dominant and selective intermediate oxidants.	acetyldioxidanyl	151-163	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-25
34119969-1	2021	The combination of Co(II) and peracetic acid (PAA) is a promising advanced oxidation process for the abatement of refractory organic contaminants, and acetylperoxy (CH3CO3 ) and acetoxyl (CH3CO2 ) radicals are generally recognized as the dominant and selective intermediate oxidants.	ch3co3	165-171	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-25
34119969-1	2021	The combination of Co(II) and peracetic acid (PAA) is a promising advanced oxidation process for the abatement of refractory organic contaminants, and acetylperoxy (CH3CO3 ) and acetoxyl (CH3CO2 ) radicals are generally recognized as the dominant and selective intermediate oxidants.	Benzoyl Peroxide	178-186	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-25
34119969-1	2021	The combination of Co(II) and peracetic acid (PAA) is a promising advanced oxidation process for the abatement of refractory organic contaminants, and acetylperoxy (CH3CO3 ) and acetoxyl (CH3CO2 ) radicals are generally recognized as the dominant and selective intermediate oxidants.	ch3co2 )	188-196	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-25
34119969-3	2021	Herein, we confirmed that Co(II)/PAA reaction enables the generation of Co(IV) at acidic conditions based on multiple lines of evidences, including methyl phenyl sulfoxide (PMSO)-based probe experiments, 18O isotope-labeling technique, and in situ Raman spectroscopy.	co(iv)	72-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-32
34119969-3	2021	Herein, we confirmed that Co(II)/PAA reaction enables the generation of Co(IV) at acidic conditions based on multiple lines of evidences, including methyl phenyl sulfoxide (PMSO)-based probe experiments, 18O isotope-labeling technique, and in situ Raman spectroscopy.	methyl phenyl sulfoxide	148-171	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-32
34119969-3	2021	Herein, we confirmed that Co(II)/PAA reaction enables the generation of Co(IV) at acidic conditions based on multiple lines of evidences, including methyl phenyl sulfoxide (PMSO)-based probe experiments, 18O isotope-labeling technique, and in situ Raman spectroscopy.	pmso	173-177	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-32
34119969-6	2021	The presence of H2O2 competitively consumes both Co(IV) and reactive radicals generated from Co(II)/PAA process, and thus, leading to an undesirably decline in catalytic performance.	Hydrogen Peroxide	16-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-99
34119969-6	2021	The presence of H2O2 competitively consumes both Co(IV) and reactive radicals generated from Co(II)/PAA process, and thus, leading to an undesirably decline in catalytic performance.	co(iv)	49-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-99
34119969-6	2021	The presence of H2O2 competitively consumes both Co(IV) and reactive radicals generated from Co(II)/PAA process, and thus, leading to an undesirably decline in catalytic performance.	Peracetic Acid	100-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-99
34119969-8	2021	Our findings enrich the fundamental understanding of Co(II) and PAA reaction and will be useful for the application of Co(IV)-mediated processes.	co(iv)	119-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-59
34250993-1	2021	Herein, a Co(ii)-based metallo-polymer (Co-tpy-L) with a three armed non-conjugated terpyridine ligand is synthesized using solvent-solvent interfacial polymerization.	co-tpy-l	40-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-16
34250993-1	2021	Herein, a Co(ii)-based metallo-polymer (Co-tpy-L) with a three armed non-conjugated terpyridine ligand is synthesized using solvent-solvent interfacial polymerization.	2,2':6',2''-Terpyridine	84-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-16
34260202-5	2021	Combined computational and experimental studies have shed light on the underlying stepwise radical mechanism for this new Co(II)-based cascade bicyclization that involves the relay of several Co-supported C-centered radical intermediates, including alpha-, beta-, gamma-, and epsilon-metalloalkyl radicals.	-, beta-, gamma-, and epsilon-metalloalkyl radicals	254-305	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-128
34264072-4	2021	This approach has been validated in our study of CoII/CoI redox transformation for Co tetraphenylporphyrin (CoTPP) immobilized on carbon cloth and multiwalled carbon nanotubes (CNTs) - one of the most active heterogeneous molecular catalysts in carbon dioxide (CO2) electroreduction.	co tetraphenylporphyrin	83-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-53
34282613-1	2021	A highly efficient catalytic method has been developed for asymmetric radical cyclopropanation of alkenes with in situ-generated alpha-heteroaryldiazomethanes via Co(II)-based metalloradical catalysis (MRC).	Alkenes	98-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	163-169
34282613-1	2021	A highly efficient catalytic method has been developed for asymmetric radical cyclopropanation of alkenes with in situ-generated alpha-heteroaryldiazomethanes via Co(II)-based metalloradical catalysis (MRC).	alpha-heteroaryldiazomethanes	129-158	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	163-169
34282613-2	2021	Through fine-tuning the cavity-like environments of newly-synthesized D2-symmetric chiral amidoporphyrins as the supporting ligand, the optimized Co(II)-based metalloradical system is broadly applicable to alpha-pyridyl and other alpha-heteroaryldiazomethanes for asymmetric cyclopropanation of wide-ranging alkenes, including several types of challenging substrates.	amidoporphyrins	90-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	146-152
34282613-2	2021	Through fine-tuning the cavity-like environments of newly-synthesized D2-symmetric chiral amidoporphyrins as the supporting ligand, the optimized Co(II)-based metalloradical system is broadly applicable to alpha-pyridyl and other alpha-heteroaryldiazomethanes for asymmetric cyclopropanation of wide-ranging alkenes, including several types of challenging substrates.	alpha-pyridyl	206-219	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	146-152
34282613-2	2021	Through fine-tuning the cavity-like environments of newly-synthesized D2-symmetric chiral amidoporphyrins as the supporting ligand, the optimized Co(II)-based metalloradical system is broadly applicable to alpha-pyridyl and other alpha-heteroaryldiazomethanes for asymmetric cyclopropanation of wide-ranging alkenes, including several types of challenging substrates.	alpha-heteroaryldiazomethanes	230-259	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	146-152
34282613-2	2021	Through fine-tuning the cavity-like environments of newly-synthesized D2-symmetric chiral amidoporphyrins as the supporting ligand, the optimized Co(II)-based metalloradical system is broadly applicable to alpha-pyridyl and other alpha-heteroaryldiazomethanes for asymmetric cyclopropanation of wide-ranging alkenes, including several types of challenging substrates.	Alkenes	308-315	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	146-152
34282613-4	2021	Combined computational and experimental studies further support the underlying stepwise radical mechanism of the Co(II)-based olefin cyclopropanation involving alpha- and gamma-metalloalkyl radicals as the key intermediates.	Alkenes	126-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-119
34282613-4	2021	Combined computational and experimental studies further support the underlying stepwise radical mechanism of the Co(II)-based olefin cyclopropanation involving alpha- and gamma-metalloalkyl radicals as the key intermediates.	alpha- and gamma-metalloalkyl radicals	160-198	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-119
34260202-3	2021	As the first application of metalloradical catalysis (MRC) for controlling enantioselectivity as well as diastereoselectivity in radical cascade cyclization, we herein report the development of a Co(II)-based catalytic system for asymmetric radical bicyclization of 1,6-enynes with diazo compounds.	1,6-enynes	266-276	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	196-202
34260202-3	2021	As the first application of metalloradical catalysis (MRC) for controlling enantioselectivity as well as diastereoselectivity in radical cascade cyclization, we herein report the development of a Co(II)-based catalytic system for asymmetric radical bicyclization of 1,6-enynes with diazo compounds.	diazo compounds	282-297	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	196-202
34260202-4	2021	Through the fine-tuning of D2-symmetric chiral amidoporphyrins as the supporting ligands, the Co(II)-catalyzed radical cascade process, which proceeds in a single operation under mild conditions, enables asymmetric construction of multisubstituted cyclopropane-fused tetrahydrofurans bearing three contiguous stereogenic centers, including two all-carbon quaternary centers, in high yields with excellent stereoselectivities.	amidoporphyrins	47-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-100
34260202-4	2021	Through the fine-tuning of D2-symmetric chiral amidoporphyrins as the supporting ligands, the Co(II)-catalyzed radical cascade process, which proceeds in a single operation under mild conditions, enables asymmetric construction of multisubstituted cyclopropane-fused tetrahydrofurans bearing three contiguous stereogenic centers, including two all-carbon quaternary centers, in high yields with excellent stereoselectivities.	cyclopropane	248-260	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-100
34260202-4	2021	Through the fine-tuning of D2-symmetric chiral amidoporphyrins as the supporting ligands, the Co(II)-catalyzed radical cascade process, which proceeds in a single operation under mild conditions, enables asymmetric construction of multisubstituted cyclopropane-fused tetrahydrofurans bearing three contiguous stereogenic centers, including two all-carbon quaternary centers, in high yields with excellent stereoselectivities.	Furans	267-283	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-100
34260202-4	2021	Through the fine-tuning of D2-symmetric chiral amidoporphyrins as the supporting ligands, the Co(II)-catalyzed radical cascade process, which proceeds in a single operation under mild conditions, enables asymmetric construction of multisubstituted cyclopropane-fused tetrahydrofurans bearing three contiguous stereogenic centers, including two all-carbon quaternary centers, in high yields with excellent stereoselectivities.	Carbon	348-354	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-100
34264072-4	2021	This approach has been validated in our study of CoII/CoI redox transformation for Co tetraphenylporphyrin (CoTPP) immobilized on carbon cloth and multiwalled carbon nanotubes (CNTs) - one of the most active heterogeneous molecular catalysts in carbon dioxide (CO2) electroreduction.	Carbon Dioxide	261-264	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-53
34264072-4	2021	This approach has been validated in our study of CoII/CoI redox transformation for Co tetraphenylporphyrin (CoTPP) immobilized on carbon cloth and multiwalled carbon nanotubes (CNTs) - one of the most active heterogeneous molecular catalysts in carbon dioxide (CO2) electroreduction.	cotpp	108-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-53
34264072-4	2021	This approach has been validated in our study of CoII/CoI redox transformation for Co tetraphenylporphyrin (CoTPP) immobilized on carbon cloth and multiwalled carbon nanotubes (CNTs) - one of the most active heterogeneous molecular catalysts in carbon dioxide (CO2) electroreduction.	Carbon	130-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-53
34264072-4	2021	This approach has been validated in our study of CoII/CoI redox transformation for Co tetraphenylporphyrin (CoTPP) immobilized on carbon cloth and multiwalled carbon nanotubes (CNTs) - one of the most active heterogeneous molecular catalysts in carbon dioxide (CO2) electroreduction.	Carbon	159-165	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-53
34264072-4	2021	This approach has been validated in our study of CoII/CoI redox transformation for Co tetraphenylporphyrin (CoTPP) immobilized on carbon cloth and multiwalled carbon nanotubes (CNTs) - one of the most active heterogeneous molecular catalysts in carbon dioxide (CO2) electroreduction.	Carbon Dioxide	245-259	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-53
34449618-7	2021	The Fe(III) ions were mainly taken up when they were in two-component mixtures with Co(II) ions at pH 4, whereas Cu(II) ions were preferred when they were in two-component mixtures with Co(II) ions at pH 6.	ferric sulfate	4-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-90
34062038-4	2021	Mechanism studies indicate that the accompanying Zn 2+ generated from zinc reduction of the Co II complex plays a critical role to initiate a plausible Co I /Co III catalytic cycle.	Zinc	49-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-97
34394837-11	2021	PQ downregulated SLC7A11 and GPX4 expression and upregulated Cox2 expression significantly, which were important markers in ferroptosis.	Paraquat	0-2	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-65
34449618-7	2021	The Fe(III) ions were mainly taken up when they were in two-component mixtures with Co(II) ions at pH 4, whereas Cu(II) ions were preferred when they were in two-component mixtures with Co(II) ions at pH 6.	ferric sulfate	4-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	186-192
34449618-7	2021	The Fe(III) ions were mainly taken up when they were in two-component mixtures with Co(II) ions at pH 4, whereas Cu(II) ions were preferred when they were in two-component mixtures with Co(II) ions at pH 6.	cu(ii)	113-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	186-192
34290057-5	2021	PGE2 induction requires a nuclear factor kappaB-independent, TLR4-p38MAPK-Cox2 pathway activation.	Dinoprostone	0-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-78
34296855-5	2021	The induction of Li(I) ions is manifested in the generation of hydroxides during the dissociation of the Co(II) solvation structure to trigger the tetrahedral coordination behavior of Co(II).	li(i)	17-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-111
34296855-5	2021	The induction of Li(I) ions is manifested in the generation of hydroxides during the dissociation of the Co(II) solvation structure to trigger the tetrahedral coordination behavior of Co(II).	li(i)	17-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	184-190
34296855-5	2021	The induction of Li(I) ions is manifested in the generation of hydroxides during the dissociation of the Co(II) solvation structure to trigger the tetrahedral coordination behavior of Co(II).	Hydroxides	63-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-111
34296855-5	2021	The induction of Li(I) ions is manifested in the generation of hydroxides during the dissociation of the Co(II) solvation structure to trigger the tetrahedral coordination behavior of Co(II).	Hydroxides	63-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	184-190
34439757-6	2021	Additionally, the RA-RF significantly reduced ROS production, IL-6, IL-8, TNF-alpha, and COX-2.	rosmarinic acid	18-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-94
34190272-8	2021	This suggests that the steric hindrance of the quinolyl rings around the Co ion produces a coordination atmosphere that is weaker than that observed with pyridyl rings, which facilitates a change in the CoIII ions to CoII.	co ion	73-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	217-221
34290057-8	2021	Analysis of clinical samples and public domain data revealed increased expression of Cox2, the rate-limiting enzyme of PGE2 biosynthesis, in inflamed tissues, and especially in colon Vimentin+Twist2+ stromal cells, in about 60% of patients with active Crohn"s disease or ulcerative colitis.	Dinoprostone	119-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-89
34354940-4	2021	Nimesulide is a selective COX-2 inhibitor that has shown anticancer effects in neoplastic pancreatic cells.	nimesulide	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-31
34280168-0	2021	Adsorption of Co(II) from aqueous solution using municipal sludge biochar modified by HNO3.	Nitric Acid	86-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-20
34368529-3	2021	In this work, amorphous copper oxide and doped binary- and ternary-metal oxides (containing CoII, NiII, and CuII) have been prepared on the surface of fluorine-doped tin oxide by a facile electrodeposition route followed by thermal treatment.	cupric oxide	24-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-96
34368529-3	2021	In this work, amorphous copper oxide and doped binary- and ternary-metal oxides (containing CoII, NiII, and CuII) have been prepared on the surface of fluorine-doped tin oxide by a facile electrodeposition route followed by thermal treatment.	metal oxides	67-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-96
34368529-3	2021	In this work, amorphous copper oxide and doped binary- and ternary-metal oxides (containing CoII, NiII, and CuII) have been prepared on the surface of fluorine-doped tin oxide by a facile electrodeposition route followed by thermal treatment.	Fluorine	151-159	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-96
34368529-3	2021	In this work, amorphous copper oxide and doped binary- and ternary-metal oxides (containing CoII, NiII, and CuII) have been prepared on the surface of fluorine-doped tin oxide by a facile electrodeposition route followed by thermal treatment.	stannic oxide	166-175	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-96
34356813-6	2021	Epiloliolide effectively increased the proliferation and migration of human periodontal ligament cells without cytotoxicity and suppressed the protein expression of proinflammatory mediators and cytokines, such as iNOS, COX-2, TNF-alpha, IL-6, and IL-1beta, by downregulating NLRP3 activated by PG-LPS.	7-epi-Loliolide	0-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	220-225
34356813-6	2021	Epiloliolide effectively increased the proliferation and migration of human periodontal ligament cells without cytotoxicity and suppressed the protein expression of proinflammatory mediators and cytokines, such as iNOS, COX-2, TNF-alpha, IL-6, and IL-1beta, by downregulating NLRP3 activated by PG-LPS.	pg-lps	295-301	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	220-225
34125515-1	2021	We prepared four new complexes, 4a,b and 5a,b, from polyimido sulfur-centered ligands with FeII and CoII amides.	polyimido sulfur	52-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-104
34219743-5	2021	The main species of Co(II) and Fe(III) in EAN are likely (Co(NO3)4)2- and (Fe(NO3)4)-, respectively.	ethylammonium	42-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-26
34219743-5	2021	The main species of Co(II) and Fe(III) in EAN are likely (Co(NO3)4)2- and (Fe(NO3)4)-, respectively.	co(no3)4)2	58-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-26
34219743-5	2021	The main species of Co(II) and Fe(III) in EAN are likely (Co(NO3)4)2- and (Fe(NO3)4)-, respectively.	fe(no3)4)	75-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-26
34272392-6	2021	Mechanistic studies strongly support that the reaction involves direct halogen atom abstraction via single electron transfer to difluoroalkyl bromides from the in situ formed cobalt(I) species, thus realizing a Co(I)/Co(II)/Co(III) catalytic cycle.	Halogens	71-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	217-223
34272392-6	2021	Mechanistic studies strongly support that the reaction involves direct halogen atom abstraction via single electron transfer to difluoroalkyl bromides from the in situ formed cobalt(I) species, thus realizing a Co(I)/Co(II)/Co(III) catalytic cycle.	difluoroalkyl bromides	128-150	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	217-223
34272392-6	2021	Mechanistic studies strongly support that the reaction involves direct halogen atom abstraction via single electron transfer to difluoroalkyl bromides from the in situ formed cobalt(I) species, thus realizing a Co(I)/Co(II)/Co(III) catalytic cycle.	Cobalt	175-184	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	217-223
34272392-6	2021	Mechanistic studies strongly support that the reaction involves direct halogen atom abstraction via single electron transfer to difluoroalkyl bromides from the in situ formed cobalt(I) species, thus realizing a Co(I)/Co(II)/Co(III) catalytic cycle.	co(iii)	224-231	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	217-223
34128639-3	2021	At pH 7.0, other metal ions (i.e., Fe(II), Fe(III), Mn(II), Mn(III), Co(II), Cu(II), and Ni(II)) in 10 mM phosphate could activate PAA to oxidize SMX only up to 20%.	Metals	17-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-75
34128639-3	2021	At pH 7.0, other metal ions (i.e., Fe(II), Fe(III), Mn(II), Mn(III), Co(II), Cu(II), and Ni(II)) in 10 mM phosphate could activate PAA to oxidize SMX only up to 20%.	Phosphates	106-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-75
34128639-3	2021	At pH 7.0, other metal ions (i.e., Fe(II), Fe(III), Mn(II), Mn(III), Co(II), Cu(II), and Ni(II)) in 10 mM phosphate could activate PAA to oxidize SMX only up to 20%.	Peracetic Acid	131-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-75
34128639-3	2021	At pH 7.0, other metal ions (i.e., Fe(II), Fe(III), Mn(II), Mn(III), Co(II), Cu(II), and Ni(II)) in 10 mM phosphate could activate PAA to oxidize SMX only up to 20%.	Sulfamethoxazole	146-149	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-75
34304363-1	2021	Celecoxib is a non-steroidal anti-inflammatory drug (NSAID) and a representative selective cyclooxygenase (COX)-2 inhibitor, which is commonly prescribed for osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute pain, and primary dysmenorrhea.	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-113
34080888-1	2021	Aim: This study investigated our Enzymelinks, COX-2-10aa-mPGES-1 and COX-2-10aa-PGIS, as cellular cross-screening targets for quick identification of lead compounds to inhibit inflammatory PGE2 biosynthesis while maintaining prostacyclin synthesis.	Dinoprostone	189-193	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
34080888-5	2021	The top compound that specifically inhibited inflammatory PGE2 biosynthesis alone without affecting COX-2 coupled to PGI2 synthase (PGIS) for PGI2 biosynthesis was obtained.	Epoprostenol	142-146	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-105
34568119-7	2021	The acceptance of Diclofenac is partly attributed to being a potent COX-2 inhibitor with the lowest IC50 and its rapid onset of action at lowest effective dose.	Diclofenac	18-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-73
34152775-4	2021	Calculation reveals a spin state change from the quartet cobalt(II) complex to a doublet Co(II)-carbene species for facile Z-selective and enantioselective nucleophilic addition.	Cobalt(2+)	57-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-95
34258250-5	2021	Pretreatment with silibinin attenuated the up-regulation of COX-2 and inducible nitric oxide synthase (iNOS) in H. pylori-infected MKN-1 cells and mouse stomach.	Silybin	18-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-65
34258250-8	2021	Taken together, these findings suggest that silibinin exerts anti-inflammatory effects against H. pylori infection through suppression of NF-kappaB and STAT3 and subsequently, expression of COX-2 and iNOS.	Silybin	44-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	190-195
34152775-4	2021	Calculation reveals a spin state change from the quartet cobalt(II) complex to a doublet Co(II)-carbene species for facile Z-selective and enantioselective nucleophilic addition.	carbene	96-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-95
34209679-8	2021	The COX-2, Tie2, and other factors that control the pro-angiogenic activity of TAMs are also discussed.	tams	79-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
34262619-12	2021	Conclusions: The combination treatment of the most commonly used SYSADOA drug, JOINS, and selective COX-2 inhibitor celecoxib as the representative NSAID for knee OA treatment, can be compared with celecoxib alone treatment to determine the safety or therapeutic effect.	Celecoxib	116-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-105
34248399-0	2021	Two Co(II) coordination polymers: magnetic properties and application values against chronic subdural hematoma.	Polymers	24-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
34277459-0	2021	Retraction: Combination of Tanshinone IIA and Cisplatin Inhibits Esophageal Squamous Cell Carcinoma by Down-Regulating NF-kB/COX-2/VEGF Pathway.	tanshinone	27-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-130
34277459-0	2021	Retraction: Combination of Tanshinone IIA and Cisplatin Inhibits Esophageal Squamous Cell Carcinoma by Down-Regulating NF-kB/COX-2/VEGF Pathway.	Cisplatin	46-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-130
34248399-1	2021	In this current experiment, by applying the mixed-ligand synthesis method, two coordination polymers (CPs) containing Co(II) were created triumphantly with reaction between 1,3-bis(1-imidazoly)benzene (mbib) and Co(II) salts with the aid of diverse carboxylic ligands, and their chemical formulae are (Co3(opda)3(mbib)4(H2O)4) 2H2O (1, H2opda is 1,2-phenylenediacetic acid) and (Co(mpda)(mbib)) H2O (2, H2mpda is 1,3-phenylenediacetic acid).	Water	320-323	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-124
34248399-1	2021	In this current experiment, by applying the mixed-ligand synthesis method, two coordination polymers (CPs) containing Co(II) were created triumphantly with reaction between 1,3-bis(1-imidazoly)benzene (mbib) and Co(II) salts with the aid of diverse carboxylic ligands, and their chemical formulae are (Co3(opda)3(mbib)4(H2O)4) 2H2O (1, H2opda is 1,2-phenylenediacetic acid) and (Co(mpda)(mbib)) H2O (2, H2mpda is 1,3-phenylenediacetic acid).	Water	320-323	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	212-218
34248399-1	2021	In this current experiment, by applying the mixed-ligand synthesis method, two coordination polymers (CPs) containing Co(II) were created triumphantly with reaction between 1,3-bis(1-imidazoly)benzene (mbib) and Co(II) salts with the aid of diverse carboxylic ligands, and their chemical formulae are (Co3(opda)3(mbib)4(H2O)4) 2H2O (1, H2opda is 1,2-phenylenediacetic acid) and (Co(mpda)(mbib)) H2O (2, H2mpda is 1,3-phenylenediacetic acid).	Water	395-398	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-124
34248399-1	2021	In this current experiment, by applying the mixed-ligand synthesis method, two coordination polymers (CPs) containing Co(II) were created triumphantly with reaction between 1,3-bis(1-imidazoly)benzene (mbib) and Co(II) salts with the aid of diverse carboxylic ligands, and their chemical formulae are (Co3(opda)3(mbib)4(H2O)4) 2H2O (1, H2opda is 1,2-phenylenediacetic acid) and (Co(mpda)(mbib)) H2O (2, H2mpda is 1,3-phenylenediacetic acid).	Water	395-398	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	212-218
34124878-0	2021	Synergistic Effect of Co(III) and Co(II) in a 3D Structured Co3O4/Carbon Felt Electrode for Enhanced Electrochemical Nitrate Reduction Reaction.	co3o4	60-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-40
34234507-3	2021	This study aims to address the underlying mechanisms of TNF-alpha-induced COX-2/PGE2 expression.	Dinoprostone	80-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
34239773-8	2021	In vitro, subclinical doses of platinum-based drugs prevented the generation of COX-2+ M-MDSCs induced by tumor cells from melanoma patients.	Platinum	31-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-85
34239773-10	2021	In treated patients, expression of COX-2 and arginase-1 in M-MDSCs was significantly decreased after two rounds of cisplatin, indicating inhibition of STAT3 signaling.	Cisplatin	115-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40
34202006-0	2021	Structural and Thermal Investigations of Co(II) and Ni(II) Coordination Polymers Based on biphenyl-4,4"-dioxydiacetate Linker.	biphenyl-4,4"-dioxydiacetate	90-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-47
34234507-12	2021	Phosphorylation of FoxO1 could enhance its interaction with the COX-2 promoter element revealed by ChIP assay, which was attenuated by AS1842856.	5-amino-7-(cyclohexylamino)-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid	135-144	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-69
34234507-13	2021	Conclusion: Our results suggested that TNF-alpha-induced COX-2/PGE2 upregulation is mediated through TNFR1-dependent MitoROS/PKCalpha/p38 MAPK and JNK1/2 cascade to activate FoxO1 binding with the COX-2 promoter in HCFs.	Dinoprostone	63-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-62
34234507-13	2021	Conclusion: Our results suggested that TNF-alpha-induced COX-2/PGE2 upregulation is mediated through TNFR1-dependent MitoROS/PKCalpha/p38 MAPK and JNK1/2 cascade to activate FoxO1 binding with the COX-2 promoter in HCFs.	Dinoprostone	63-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	197-202
34202163-6	2021	Molecular docking studies revealed that lusianthridin bound to the entrance site of the cyclooxygenase-1 (COX-1) enzyme and probably the active region of the cyclooxygenase-2 (COX-2) enzyme.	lusianthridin	40-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	176-181
34202163-7	2021	In addition, lusianthridin showed inhibitory effects on both COX-1 and COX-2 enzymatic activities (IC50 value of 10.81 +- 1.12 microM and 0.17 +- 1.62 microM, respectively).	lusianthridin	13-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-76
34100579-2	2021	We constructed an acid-/base-stable Co(II)-framework with a unique network topology, wherein unidirectional porous channels are decorated by anionic (Co2(mu2-OH)(COO)4(H2O)3) secondary building units and neutral (CoN2(COO)2) nodes.	co2(mu2-oh)	150-161	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-42
34100579-2	2021	We constructed an acid-/base-stable Co(II)-framework with a unique network topology, wherein unidirectional porous channels are decorated by anionic (Co2(mu2-OH)(COO)4(H2O)3) secondary building units and neutral (CoN2(COO)2) nodes.	Water	168-171	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-42
34124878-0	2021	Synergistic Effect of Co(III) and Co(II) in a 3D Structured Co3O4/Carbon Felt Electrode for Enhanced Electrochemical Nitrate Reduction Reaction.	Carbon	66-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-40
34166397-2	2021	Here, we have extended these observations, using primary myometrial cell cultures to show that the cAMP agonist, forskolin, enhances IL-1beta-driven COX-2 expression.	Colforsin	113-122	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	149-154
34166397-4	2021	AKIP1 knockdown reversed the effect of forskolin, such that its addition inhibited IL-1beta-induced COX-2 mRNA expression and reduced the IL-1beta-induced increase in nuclear levels of p65 and c-jun.	Colforsin	39-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-105
34124878-0	2021	Synergistic Effect of Co(III) and Co(II) in a 3D Structured Co3O4/Carbon Felt Electrode for Enhanced Electrochemical Nitrate Reduction Reaction.	Nitrates	117-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-40
34124878-7	2021	Thus, this study suggests that building 3D structure and optimizing Co(II)/Co(III) ratio are important for designing efficient Co3O4 electrocatalyst for ENRR.	co3o4	127-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-74
34201817-6	2021	The inhibition of COX-2 enzyme activity, but not protein expression was observed for ASA and one Salix extract.	Aspirin	85-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-23
34075925-0	2021	Designed pincer ligand supported Co(II)-based catalysts for dehydrogenative activation of alcohols: Studies on N-alkylation of amines, alpha-alkylation of ketones and synthesis of quinolines.	Alcohols	90-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-39
34075925-0	2021	Designed pincer ligand supported Co(II)-based catalysts for dehydrogenative activation of alcohols: Studies on N-alkylation of amines, alpha-alkylation of ketones and synthesis of quinolines.	Amines	127-133	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-39
34075925-0	2021	Designed pincer ligand supported Co(II)-based catalysts for dehydrogenative activation of alcohols: Studies on N-alkylation of amines, alpha-alkylation of ketones and synthesis of quinolines.	Ketones	155-162	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-39
34075925-0	2021	Designed pincer ligand supported Co(II)-based catalysts for dehydrogenative activation of alcohols: Studies on N-alkylation of amines, alpha-alkylation of ketones and synthesis of quinolines.	Quinolines	180-190	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-39
34203751-0	2021	The Synthesis of a Bis(thiosemicarbazone) Macrocyclic Ligand and the Mn(II), Co(II), Zn(II) and 68Ga(III) Complexes.	Thiosemicarbazones	23-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-83
34085813-3	2021	We report photoinduced VT in benzene solvated crystals of Co(diox)2(4-CN-py)2 illuminated with blue 450 nm light at 30 K with a very high yield (80%) of metastable hs-CoII states, and we also show evidence of the de-excitation of these photoinduced metastable states using red 660 nm light.	Benzene	29-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	167-171
34085813-3	2021	We report photoinduced VT in benzene solvated crystals of Co(diox)2(4-CN-py)2 illuminated with blue 450 nm light at 30 K with a very high yield (80%) of metastable hs-CoII states, and we also show evidence of the de-excitation of these photoinduced metastable states using red 660 nm light.	co(diox)2(4-cn-py)2	58-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	167-171
34085813-3	2021	We report photoinduced VT in benzene solvated crystals of Co(diox)2(4-CN-py)2 illuminated with blue 450 nm light at 30 K with a very high yield (80%) of metastable hs-CoII states, and we also show evidence of the de-excitation of these photoinduced metastable states using red 660 nm light.	Hydrogen	164-166	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	167-171
34085813-4	2021	Such high-yield light-induced VT had never been experimentally observed in molecular crystals of cobalt tautomers, proving that the 450 nm light illumination is triggering a chain of events that leads to the ls-CoIII to hs-CoII interconversion.	Cobalt	97-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	223-227
34085831-4	2021	X-ray photoelectron spectroscopy and X-ray absorption near-edge spectroscopy (XANES) indicated the presence of CoII and AlIII centers in DUT-5-CoH and DUT-5-Co after catalysis.	dut-5-coh	137-146	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	111-115
34085831-4	2021	X-ray photoelectron spectroscopy and X-ray absorption near-edge spectroscopy (XANES) indicated the presence of CoII and AlIII centers in DUT-5-CoH and DUT-5-Co after catalysis.	dut-5-co	151-159	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	111-115
34075750-2	2021	Herein, we report a gas-driven conductive MOF (A) constructed from calix(4)resorcinarene macrocycle and Co(II) cations, which shows the conductivity enhancement by about eight orders of magnitude through NO2 adsorption.	Nitrogen Dioxide	204-207	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-110
34075750-5	2021	When NO2 is evacuated, MOF A quickly changes from a conductor back to an insulator in 42 s. In the crystal structure of NO2-adsorbed MOF (termed as A-NO2), NO2 molecule connects Co(II) and uncoordinated carboxylate groups through hydrogen-bonding interactions to form a conductive pathway, greatly reducing the electron transmission distance between each two metal clusters.	Nitrogen Dioxide	5-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	178-184
34075750-5	2021	When NO2 is evacuated, MOF A quickly changes from a conductor back to an insulator in 42 s. In the crystal structure of NO2-adsorbed MOF (termed as A-NO2), NO2 molecule connects Co(II) and uncoordinated carboxylate groups through hydrogen-bonding interactions to form a conductive pathway, greatly reducing the electron transmission distance between each two metal clusters.	Nitrogen Dioxide	120-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	178-184
34075750-5	2021	When NO2 is evacuated, MOF A quickly changes from a conductor back to an insulator in 42 s. In the crystal structure of NO2-adsorbed MOF (termed as A-NO2), NO2 molecule connects Co(II) and uncoordinated carboxylate groups through hydrogen-bonding interactions to form a conductive pathway, greatly reducing the electron transmission distance between each two metal clusters.	Nitrogen Dioxide	156-159	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	178-184
34075750-5	2021	When NO2 is evacuated, MOF A quickly changes from a conductor back to an insulator in 42 s. In the crystal structure of NO2-adsorbed MOF (termed as A-NO2), NO2 molecule connects Co(II) and uncoordinated carboxylate groups through hydrogen-bonding interactions to form a conductive pathway, greatly reducing the electron transmission distance between each two metal clusters.	Hydrogen	230-238	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	178-184
34075750-5	2021	When NO2 is evacuated, MOF A quickly changes from a conductor back to an insulator in 42 s. In the crystal structure of NO2-adsorbed MOF (termed as A-NO2), NO2 molecule connects Co(II) and uncoordinated carboxylate groups through hydrogen-bonding interactions to form a conductive pathway, greatly reducing the electron transmission distance between each two metal clusters.	Metals	359-364	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	178-184
34206683-2	2021	The structural aspects of these hybrid metallaoxidoborates containing Cd(II), Co(II), Cu(II), Ga(III), In(III), Mn(II), Ni(II) or Zn(II) metal centers are discussed in this review.	metallaoxidoborates	39-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-84
34211959-1	2021	In the search for novel, metal-based drug complexes that may be of value as anticancer agents, five new transition metal complexes of sulfaclozine (SCZ) with Cu(II), Co(II), Ni(II), Zn(II), and Fe(II) were successfully synthesized.	Metals	25-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	166-172
34211959-1	2021	In the search for novel, metal-based drug complexes that may be of value as anticancer agents, five new transition metal complexes of sulfaclozine (SCZ) with Cu(II), Co(II), Ni(II), Zn(II), and Fe(II) were successfully synthesized.	Metals	115-120	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	166-172
34211959-1	2021	In the search for novel, metal-based drug complexes that may be of value as anticancer agents, five new transition metal complexes of sulfaclozine (SCZ) with Cu(II), Co(II), Ni(II), Zn(II), and Fe(II) were successfully synthesized.	sulfaclozine	134-146	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	166-172
34211959-1	2021	In the search for novel, metal-based drug complexes that may be of value as anticancer agents, five new transition metal complexes of sulfaclozine (SCZ) with Cu(II), Co(II), Ni(II), Zn(II), and Fe(II) were successfully synthesized.	sulfaclozine	148-151	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	166-172
34199865-7	2021	In mechanically compressed HPdLF, PA enhanced COX2 expression and PGE2 secretion.	Palmitates	34-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-50
34693072-1	2021	A catalytic radical process has been developed for asymmetric cyclopropanation of dehydroaminocarboxylates with in situ-generated alpha-aryldiazomethanes via Co(II)-based metalloradical catalysis (MRC).	dehydroaminocarboxylates	82-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	158-164
34693072-1	2021	A catalytic radical process has been developed for asymmetric cyclopropanation of dehydroaminocarboxylates with in situ-generated alpha-aryldiazomethanes via Co(II)-based metalloradical catalysis (MRC).	alpha-aryldiazomethanes	130-153	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	158-164
34693072-2	2021	Through fine-tuning the environments of D 2-symmetric chiral amidoporphyrin platform as the supporting ligands, the Co(II)-metalloradical system can effectively activate various alpha-aryldiazomethanes to cyclopropanate different dehydroaminocarboxylates under mild conditions, enabling the stereoselective synthesis of chiral cyclopropyl alpha-amino acid derivatives.	amidoporphyrin	61-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-122
34693072-2	2021	Through fine-tuning the environments of D 2-symmetric chiral amidoporphyrin platform as the supporting ligands, the Co(II)-metalloradical system can effectively activate various alpha-aryldiazomethanes to cyclopropanate different dehydroaminocarboxylates under mild conditions, enabling the stereoselective synthesis of chiral cyclopropyl alpha-amino acid derivatives.	alpha-aryldiazomethanes	178-201	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-122
34693072-2	2021	Through fine-tuning the environments of D 2-symmetric chiral amidoporphyrin platform as the supporting ligands, the Co(II)-metalloradical system can effectively activate various alpha-aryldiazomethanes to cyclopropanate different dehydroaminocarboxylates under mild conditions, enabling the stereoselective synthesis of chiral cyclopropyl alpha-amino acid derivatives.	cyclopropanate	205-219	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-122
34693072-2	2021	Through fine-tuning the environments of D 2-symmetric chiral amidoporphyrin platform as the supporting ligands, the Co(II)-metalloradical system can effectively activate various alpha-aryldiazomethanes to cyclopropanate different dehydroaminocarboxylates under mild conditions, enabling the stereoselective synthesis of chiral cyclopropyl alpha-amino acid derivatives.	dehydroaminocarboxylates	230-254	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-122
34693072-2	2021	Through fine-tuning the environments of D 2-symmetric chiral amidoporphyrin platform as the supporting ligands, the Co(II)-metalloradical system can effectively activate various alpha-aryldiazomethanes to cyclopropanate different dehydroaminocarboxylates under mild conditions, enabling the stereoselective synthesis of chiral cyclopropyl alpha-amino acid derivatives.	cyclopropyl alpha-amino acid	327-355	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-122
34201243-6	2021	Quantitative RT-PCR analysis revealed that irinotecan at 15 microM was able to amplify the antiviral response (i.e., interferon-stimulated gene expression) of HSF exposed to PIC and reduce the expression of pro-inflammatory genes (CXCL8, IL-6 and COX-2) upon IL-1beta treatment.	Irinotecan	43-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	247-252
34135407-6	2021	In HTR-8/SVneo cells, the COX-2 inhibitors induced an increase of IL-6 and nitrite and decreased IL-4 and TGF-beta1.	Nitrites	75-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-31
34124273-8	2021	Empagliflozin and gemigliptin (individually and combined) inhibited prostaglandin E2 (PGE2) release and COX-2, iNOS gene expression in LPS-stimulated RAW 264.7 macrophages.	empagliflozin	0-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
34124273-8	2021	Empagliflozin and gemigliptin (individually and combined) inhibited prostaglandin E2 (PGE2) release and COX-2, iNOS gene expression in LPS-stimulated RAW 264.7 macrophages.	LC15-0444	18-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
34206129-11	2021	Combined fotemustine and dexamethasone therapy showed anti-inflammatory effects by inducing the synthesis of anti-inflammatory mediators at the transcriptional and post-transcriptional levels (Western blot analysis of NFkappaB, COX-2 and PGE2 expression).	fotemustine	9-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	228-233
34080112-6	2022	Molecular docking results unclose the rationale for the interaction of the compound 11b with COX-2 enzyme.	11b	84-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-98
34080112-7	2022	Further studies revealed that compound 11b exhibited effective COX-2 inhibitory activity, with half-maximal inhibitor concentration (IC50) value of 1.16 microM and selectivity index (SI = 64.66) value close to that of celecoxib (IC50 = 0.93 microM, SI = 65.47).	11b	39-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-68
34080112-7	2022	Further studies revealed that compound 11b exhibited effective COX-2 inhibitory activity, with half-maximal inhibitor concentration (IC50) value of 1.16 microM and selectivity index (SI = 64.66) value close to that of celecoxib (IC50 = 0.93 microM, SI = 65.47).	Celecoxib	218-227	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-68
34199613-7	2021	Interestingly, for those XAr with halohydroxyl quinoid structure, a Co(II)-mediated Fenton-like system could induce a stronger CL emission and higher degradation, probably due to site-specific generation of highly-effective  OH.	xar	25-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-74
34199613-7	2021	Interestingly, for those XAr with halohydroxyl quinoid structure, a Co(II)-mediated Fenton-like system could induce a stronger CL emission and higher degradation, probably due to site-specific generation of highly-effective  OH.	halohydroxyl quinoid	34-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-74
34206129-11	2021	Combined fotemustine and dexamethasone therapy showed anti-inflammatory effects by inducing the synthesis of anti-inflammatory mediators at the transcriptional and post-transcriptional levels (Western blot analysis of NFkappaB, COX-2 and PGE2 expression).	Dexamethasone	25-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	228-233
34065450-7	2021	The Co(II)/Co(III) redox switching is retained in the thick polymer films because it occurs at potentials of high polymer conductivity due to the optimum redox matching of the Co(II)/Co(III) redox pair with the organic conjugated backbone.	Polymers	60-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
34168004-14	2021	Further investigation indicated that JAK/STAT1 pathway activated by immune-cell-derived interferon gamma and MCT1/NF-kB/COX-2 pathway activated by high concentrations of tumor-derived lactate could induce PD-L1+ neutrophils.	Lactic Acid	184-191	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-125
34168004-15	2021	The latter could be significantly inhibited by COX-2 inhibitor celecoxib.	Celecoxib	63-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
34168004-18	2021	Tumor-derived lactate induces PD-L1 expression on neutrophils via MCT1/NF-kappaB/COX-2 pathway.	Lactic Acid	14-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-86
34070757-5	2021	Anthocyanins, water-soluble flavonoid species, responsible for the red-blue color in plants and commonly found in berries, exert favorable effects on the endothelial function, oxidative stress, inhibit COX-1, and COX-2 enzymes, exert antiatherogenic, antihypertensive, antiglycation, antithrombotic, and anti-inflammatory activity, ameliorate dyslipidemia and arterial stiffness.	Anthocyanins	0-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	213-218
34070757-5	2021	Anthocyanins, water-soluble flavonoid species, responsible for the red-blue color in plants and commonly found in berries, exert favorable effects on the endothelial function, oxidative stress, inhibit COX-1, and COX-2 enzymes, exert antiatherogenic, antihypertensive, antiglycation, antithrombotic, and anti-inflammatory activity, ameliorate dyslipidemia and arterial stiffness.	Water	14-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	213-218
34071141-2	2021	Dysbiosis and the overexpression of COX-2 and LDHA are important effectors in the initiation and development of the disease through chromosomal instability, PGE2 biosynthesis, and induction of the Warburg effect, respectively.	Dinoprostone	157-161	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-41
34071141-3	2021	Herein, we report the in vitro testing of some new quinoxalinone and quinazolinone Schiff"s bases as: antibacterial, COX-2 and LDHA inhibitors, and anticolorectal agents on HCT-116 and LoVo cells.	3-(1-(phenylhydrazono)-2,3,4-trihydroxybut-1-yl)quinoxalin-2-(1H)-one	51-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-122
34071141-3	2021	Herein, we report the in vitro testing of some new quinoxalinone and quinazolinone Schiff"s bases as: antibacterial, COX-2 and LDHA inhibitors, and anticolorectal agents on HCT-116 and LoVo cells.	Quinazolinones	69-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-122
34122616-6	2021	GC AGS cells treated with ghrelin showed an increase in protein expression of p-Akt, PI3K, and COX-2.	Ghrelin	26-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-100
34122616-7	2021	After cells were treated with Akt inhibitor perifosine, the protein expression of p-Akt, PI3K, and COX-2 and the cell migratory, invasion, and apoptosis were partly recovered.	perifosine	44-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-104
34122616-8	2021	After cells were treated with cyclooxygenase-2 inhibitor NS398, the protein expression of COX-2 and the cell migratory and invasion were decreased, while the rates of apoptosis were increased.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	57-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-95
34122616-9	2021	Conclusion: Ghrelin regulates cell migration, invasion, and apoptosis in GC cells through targeting PI3K/Akt/COX-2.	Ghrelin	12-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-114
34122616-10	2021	Ghrelin increases the expression of COX-2 in GC cells by targeting PI3K/Akt.	Ghrelin	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-41
34069696-3	2021	In H2O2-induced Jukat T cells, haplopine (25 and 50 muM) suppressed the productions of proinflammatory cytokines (IL-4, IL-13, and COX-2) and increased the mRNA and protein expressions of oxidative stress defense enzymes (SOD, CAT, and HO-1) in a concentration-dependent manner.	4,8-dimethoxy-7-hydroxyfuro(2,3-b)quinoline	31-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-136
34151097-2	2021	Herein, we report a novel approach for the detection and determination of fluoride ion (F-) sensing based on a salen-cobalt metal-organic framework (Co(II)-MOF).	Fluorides	74-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	149-155
34151097-2	2021	Herein, we report a novel approach for the detection and determination of fluoride ion (F-) sensing based on a salen-cobalt metal-organic framework (Co(II)-MOF).	disalicylaldehyde ethylenediamine	111-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	149-155
34151097-2	2021	Herein, we report a novel approach for the detection and determination of fluoride ion (F-) sensing based on a salen-cobalt metal-organic framework (Co(II)-MOF).	Cobalt	117-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	149-155
34151097-2	2021	Herein, we report a novel approach for the detection and determination of fluoride ion (F-) sensing based on a salen-cobalt metal-organic framework (Co(II)-MOF).	Metals	124-129	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	149-155
34151097-9	2021	Additionally, the applicability of the current Co(II)-MOF approach in different real water samples, such as tap water, drinking water, Nile River water, and wastewater, was extended.	Water	85-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-53
34151097-9	2021	Additionally, the applicability of the current Co(II)-MOF approach in different real water samples, such as tap water, drinking water, Nile River water, and wastewater, was extended.	Water	112-117	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-53
34151097-9	2021	Additionally, the applicability of the current Co(II)-MOF approach in different real water samples, such as tap water, drinking water, Nile River water, and wastewater, was extended.	Water	128-133	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-53
34151097-9	2021	Additionally, the applicability of the current Co(II)-MOF approach in different real water samples, such as tap water, drinking water, Nile River water, and wastewater, was extended.	Water	146-151	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-53
34122428-4	2021	Celecoxib, a selective COX-2 inhibitor, and aspirin, a non-selective COX-1 and COX-2 inhibitor, are being used as anti-inflammatory, analgesic and anti-pyretic drugs.	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-28
34122428-4	2021	Celecoxib, a selective COX-2 inhibitor, and aspirin, a non-selective COX-1 and COX-2 inhibitor, are being used as anti-inflammatory, analgesic and anti-pyretic drugs.	Aspirin	44-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-84
34257875-4	2021	The tetracobalt Weakley sandwich (CoII 4(H2O)2(B-alpha-PW9O34)2)10- (Co4-WS) has been one of the most extensively studied.	Water	41-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-38
34065450-7	2021	The Co(II)/Co(III) redox switching is retained in the thick polymer films because it occurs at potentials of high polymer conductivity due to the optimum redox matching of the Co(II)/Co(III) redox pair with the organic conjugated backbone.	Polymers	60-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	176-182
34065450-7	2021	The Co(II)/Co(III) redox switching is retained in the thick polymer films because it occurs at potentials of high polymer conductivity due to the optimum redox matching of the Co(II)/Co(III) redox pair with the organic conjugated backbone.	Polymers	114-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
34065450-7	2021	The Co(II)/Co(III) redox switching is retained in the thick polymer films because it occurs at potentials of high polymer conductivity due to the optimum redox matching of the Co(II)/Co(III) redox pair with the organic conjugated backbone.	Polymers	114-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	176-182
34306978-4	2021	X-ray absorption fine spectra reveal that the activation of Co (II) ions (in NH4CoPO4 H2O) to Co (III) species constructs the electrocatalytic active sites.	Water	86-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-67
34306978-4	2021	X-ray absorption fine spectra reveal that the activation of Co (II) ions (in NH4CoPO4 H2O) to Co (III) species constructs the electrocatalytic active sites.	co (iii)	94-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-67
34749615-4	2021	RSV is thought to have an impressive outcome in colorectal cancer (CRC) treatment through the vital molecules and cancer signaling pathways, including SIRT1, P53, P21, AMPK, ROS, BMP7, COX-2, NO, Caspases, Wnt, TNFs, NF-kappaB, EMT, and pentose phosphate pathway.	Resveratrol	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	185-190
34068523-7	2021	NTS and MSM also inhibited LPS-induced nuclear accumulation and binding of NF-kappaB to proinflammatory cytokines COX-2, IL-1beta, and IL-6.	nts	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-119
34093801-6	2021	Mechanismly, COX-2 was discovered to be a direct and functional target of miR-30a-3p in MHCC-97H cells.	mir-30a-3p	74-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
34093801-8	2021	In addition, we found that using a COX-2 inhibitor, celecoxib, could enhance the anti-metastatic role of miR-30a-3p in MHCC-97H cells.	Celecoxib	52-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40
34093801-8	2021	In addition, we found that using a COX-2 inhibitor, celecoxib, could enhance the anti-metastatic role of miR-30a-3p in MHCC-97H cells.	mir-30a-3p	105-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40
34093801-9	2021	Lastly, we found that decreased COX-2 protein level affected PGE2 production, leading to lower Bcl-2, Caspase-3, MMP2 and MMP9 expression but higher Bax and E-cadherin expression, which in turn culminated in higher rates of cell death and lower rates of cell migration.	Dinoprostone	61-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-37
34066392-6	2021	Data from preclinical and clinical studies show that these inflammatory lesions within the breast are associated with local NF-kappaB activation, increased aromatase activity, and elevation of pro-inflammatory mediators (TNFalpha, IL-1beta, IL-6, and COX-2-derived PGE2)-factors involved in multiple pathways of breast cancer development and progression.	Dinoprostone	265-269	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	251-256
34155432-1	2021	Transition metals such as Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Zn(II), Cd(II), and Hg(II) have been reacted with gibberellic acid (HGA) to give novel complexes, and those have been characterized by physical, spectral and analytical methods.	gibberellic acid	118-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-58
34521304-1	2021	Schiff base complexes of Cu(II), Ni(II), Co(II), VO(II) and Zn(II) ions have been synthesized by condensation of acetylaceto-4-iminoantipyrine and tyrosine.	Schiff Bases	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-47
34521304-1	2021	Schiff base complexes of Cu(II), Ni(II), Co(II), VO(II) and Zn(II) ions have been synthesized by condensation of acetylaceto-4-iminoantipyrine and tyrosine.	acetylaceto-4-iminoantipyrine	113-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-47
34521304-1	2021	Schiff base complexes of Cu(II), Ni(II), Co(II), VO(II) and Zn(II) ions have been synthesized by condensation of acetylaceto-4-iminoantipyrine and tyrosine.	Tyrosine	147-155	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-47
34155432-1	2021	Transition metals such as Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Zn(II), Cd(II), and Hg(II) have been reacted with gibberellic acid (HGA) to give novel complexes, and those have been characterized by physical, spectral and analytical methods.	glutamine hydroxamate	136-139	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-58
34155432-3	2021	The complexes (M(GA)2(H2O)2), where (M = Mn(II), Co(II), and Ni(II)) form octahedral structures, while (M(GA)2) complexes (M = Zn(II), Cd(II), and Hg(II)) display four-coordination geometry.	Gallium	17-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-55
34611370-0	2021	Photodegradation of Sulfamethoxypyridazine in UV/Co(II)/Peroxymonosulfate System: Kinetics, Influencing Factors, Degradation Pathways, and Toxicity Assessment.	Sulfamethoxypyridazine	20-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-55
34611370-0	2021	Photodegradation of Sulfamethoxypyridazine in UV/Co(II)/Peroxymonosulfate System: Kinetics, Influencing Factors, Degradation Pathways, and Toxicity Assessment.	peroxymonosulfate	56-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-55
34611370-3	2021	Then the oxidation degradation of SMP in UV/Co(II)/peroxymonosulfate (PMS) system was systematically explored.	peroxymonosulfate	51-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-50
34155432-3	2021	The complexes (M(GA)2(H2O)2), where (M = Mn(II), Co(II), and Ni(II)) form octahedral structures, while (M(GA)2) complexes (M = Zn(II), Cd(II), and Hg(II)) display four-coordination geometry.	Water	22-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-55
35525443-0	2022	Efficient degradation of antibiotics over Co(II)-doped Bi2MoO6 nanohybrid via the synergy of peroxymonosulfate activation and photocatalytic reaction under visible irradiation.	Bi(2)MoO(6)	55-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-48
34611370-3	2021	Then the oxidation degradation of SMP in UV/Co(II)/peroxymonosulfate (PMS) system was systematically explored.	pms	70-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-50
34611370-7	2021	Radical scavenger experiments indicated that hydroxyl radicals (HO ) are prevailing active species responsible for SMP removal in UV/Co(II)/PMS system.	Hydroxyl Radical	45-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	133-139
34611370-7	2021	Radical scavenger experiments indicated that hydroxyl radicals (HO ) are prevailing active species responsible for SMP removal in UV/Co(II)/PMS system.	Hydroxyl Radical	64-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	133-139
34611370-7	2021	Radical scavenger experiments indicated that hydroxyl radicals (HO ) are prevailing active species responsible for SMP removal in UV/Co(II)/PMS system.	pms	140-143	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	133-139
34611370-8	2021	The degradation of SMP in UV/Co(II)/PMS system was accomplished mainly by hydroxylation of the aromatic ring, extrusion of SO2, oxidation of NH2 group, and N - S bond cleavage.	pms	36-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-35
34611370-8	2021	The degradation of SMP in UV/Co(II)/PMS system was accomplished mainly by hydroxylation of the aromatic ring, extrusion of SO2, oxidation of NH2 group, and N - S bond cleavage.	Sulfur Dioxide	123-126	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-35
34611370-8	2021	The degradation of SMP in UV/Co(II)/PMS system was accomplished mainly by hydroxylation of the aromatic ring, extrusion of SO2, oxidation of NH2 group, and N - S bond cleavage.	Nitrogen	156-157	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-35
34611370-8	2021	The degradation of SMP in UV/Co(II)/PMS system was accomplished mainly by hydroxylation of the aromatic ring, extrusion of SO2, oxidation of NH2 group, and N - S bond cleavage.	Sulfur	160-161	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-35
34611370-10	2021	The present research indicates that UV/Co(II)/PMS system is applicable for SMP degradation in aqueous solutions and may be helpful to understand the transformation behavior of SAs.	pms	46-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-45
35525443-0	2022	Efficient degradation of antibiotics over Co(II)-doped Bi2MoO6 nanohybrid via the synergy of peroxymonosulfate activation and photocatalytic reaction under visible irradiation.	peroxymonosulfate	93-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-48
35504091-0	2022	Eugenol suppresses the proliferation and invasion of TNF-alpha-induced fibroblast-like synoviocytes via regulating NF-kappaB and COX-2.	Eugenol	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-134
35395537-5	2022	As a highly efficient catalyst for the activation of PS, Co3V2O8/PS system produces radicals of SO4 -,  OH,  O2- and 1O2 in the reaction process due to the Co(II) and V(IV) exchange electrons with S2O82- and O2.	co3v2o8	57-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	156-162
35395537-5	2022	As a highly efficient catalyst for the activation of PS, Co3V2O8/PS system produces radicals of SO4 -,  OH,  O2- and 1O2 in the reaction process due to the Co(II) and V(IV) exchange electrons with S2O82- and O2.	ps	65-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	156-162
35395537-5	2022	As a highly efficient catalyst for the activation of PS, Co3V2O8/PS system produces radicals of SO4 -,  OH,  O2- and 1O2 in the reaction process due to the Co(II) and V(IV) exchange electrons with S2O82- and O2.	sulfuric acid	96-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	156-162
35395537-5	2022	As a highly efficient catalyst for the activation of PS, Co3V2O8/PS system produces radicals of SO4 -,  OH,  O2- and 1O2 in the reaction process due to the Co(II) and V(IV) exchange electrons with S2O82- and O2.	s2o82-	197-203	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	156-162
35395537-5	2022	As a highly efficient catalyst for the activation of PS, Co3V2O8/PS system produces radicals of SO4 -,  OH,  O2- and 1O2 in the reaction process due to the Co(II) and V(IV) exchange electrons with S2O82- and O2.	Oxygen	208-210	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	156-162
35395537-6	2022	Simultaneously, the internal electron exchange occurs between Co(II)/Co(III) and V(IV)/V(V), which stabilizes the content of Co(II) and V(IV).	co(iii)	69-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-68
35395537-6	2022	Simultaneously, the internal electron exchange occurs between Co(II)/Co(III) and V(IV)/V(V), which stabilizes the content of Co(II) and V(IV).	co(iii)	69-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-131
35504091-6	2022	Eugenol reversed the promoting effect of TNF-alpha on the expression of NF-kappaB signaling pathway-related proteins as well as prostaglandin-endoperoxide synthase 2 (PTGS2, also known as COX-2) protein.	Eugenol	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	188-193
35504091-8	2022	In conclusion, eugenol may represent a novel drug to suppress the progression of RA by inhibiting NF-kappaB signaling pathway and COX-2 expression in fibroblast-like synovial cells.	Eugenol	15-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	130-135
35585779-3	2022	Identification of two isoforms of COX, COX-1 and COX-2, led to the development of selective COX-2 inhibitors which were launched as having fewer gastrointestinal side effects since gastroprotective prostaglandins produced via COX-1 are spared.	Prostaglandins	198-212	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-54
35612901-0	2022	Pd-Catalysed (3 + 2)-cycloaddition towards the generation of bioactive bis-heterocycles/identification of COX-2 inhibitors via in silico analysis.	Palladium	0-2	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-111
35612901-3	2022	In silico-based studies of bis-heterocycles on the cyclooxygenase (COX) enzyme displayed selective COX-2 inhibition.	silico	3-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-104
35612531-2	2022	Employing mononuclear cobalt-nitrite complexes with CoIII and CoII oxidation states, ((Bz3Tren)CoIII(nitrite)2)(ClO4) (1) and ((Bz3Tren)CoII(nitrite))(ClO4) (2), this report illustrates NO release coupled to stepwise oxidation of ene-diol antioxidants such as l-ascorbic acid (AH2) and catechol.	cobalt-nitrite	22-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-66
35612531-2	2022	Employing mononuclear cobalt-nitrite complexes with CoIII and CoII oxidation states, ((Bz3Tren)CoIII(nitrite)2)(ClO4) (1) and ((Bz3Tren)CoII(nitrite))(ClO4) (2), this report illustrates NO release coupled to stepwise oxidation of ene-diol antioxidants such as l-ascorbic acid (AH2) and catechol.	cobalt-nitrite	22-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	136-140
35612531-4	2022	Intriguingly, a controlled oxidation of AH2 with complex 2 results in a (CoII)-bound ascorbyl radical-anion (8).	ascorbyl radical-anion	85-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-77
35604128-2	2022	With a 0.05 mol % PyBPI-Co(II) complex, beta,gamma-unsaturated alpha-keto esters reacted with 4-hydroxycoumarin to give the adducts in 93-99% yields and 90-97% ee.	pybpi	18-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-30
35604128-2	2022	With a 0.05 mol % PyBPI-Co(II) complex, beta,gamma-unsaturated alpha-keto esters reacted with 4-hydroxycoumarin to give the adducts in 93-99% yields and 90-97% ee.	beta,gamma-unsaturated alpha-keto esters	40-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-30
35604128-2	2022	With a 0.05 mol % PyBPI-Co(II) complex, beta,gamma-unsaturated alpha-keto esters reacted with 4-hydroxycoumarin to give the adducts in 93-99% yields and 90-97% ee.	4-hydroxycoumarin	94-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-30
35604128-3	2022	Experiments and DFT calculations supported the dual activation manner, in which the tridentate ligand coordinated with Co(II) to activate the keto ester, and the hydroxyl and carbonyl groups in PyBPI interacted with 4-hydroxycoumarin via two different H bonds.	keto ester	142-152	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-125
35619002-1	2022	This study is interested in the removal of Pb(II), Cd(II), Co(II), Zn(II), and Sr(II) onto polyacrylic acid acrylonitrile talc P(AA-AN)-talc nanocomposite.	polyacrylic acid acrylonitrile	91-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
35619002-1	2022	This study is interested in the removal of Pb(II), Cd(II), Co(II), Zn(II), and Sr(II) onto polyacrylic acid acrylonitrile talc P(AA-AN)-talc nanocomposite.	talc p(aa-an)	122-135	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
35619002-1	2022	This study is interested in the removal of Pb(II), Cd(II), Co(II), Zn(II), and Sr(II) onto polyacrylic acid acrylonitrile talc P(AA-AN)-talc nanocomposite.	Talc	136-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
35610283-7	2022	Moreover, it"s in vitro efficacy in inhibiting COX-2 enzyme under both LPS stimulated intestinal cells and direct sequestration assays was found to be higher than salicylic acid and indomethacin.	Salicylic Acid	163-177	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
35610283-7	2022	Moreover, it"s in vitro efficacy in inhibiting COX-2 enzyme under both LPS stimulated intestinal cells and direct sequestration assays was found to be higher than salicylic acid and indomethacin.	Indomethacin	182-194	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
35546085-7	2022	The reactivity of the Co(III) precursor is much lower than that of the Co(II) species, leading to slower precipitation of Co(III) than that of Zn(II), thus forming the core-shell structure.	zn(ii)	143-149	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-77
35629702-3	2022	Complexes of the acetyl ferrocene imine ligand with metal(II)/(III) ions (Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II)) were fabricated.	acetyl ferrocene imine	17-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-106
35629702-3	2022	Complexes of the acetyl ferrocene imine ligand with metal(II)/(III) ions (Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II)) were fabricated.	metal(ii)	52-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-106
35587471-0	2022	Retraction: ATP Mediates NADPH Oxidase/ROS Generation and COX-2/PGE2 Expression in A549 Cells: Role of P2 Receptor-Dependent STAT3 Activation.	Dinoprostone	64-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
35583799-7	2022	In addition, we found that inhibition of AL137857.1 suppressed the expression of a series of inflammatory cytokines, including IL-1, IL-6, TNF-alpha, Cox2 and iNOS.	al137857	41-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	150-154
35506986-2	2022	The total synthesis of 7 members of the acyloin family was achieved via a HWE reaction followed by Mukaiyama-Isayama hydration, using novel Co(II) and Co(III) Schiff base SALPN complexes as catalysts for the key enone hydration step.	acyloin	40-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-146
35490796-2	2022	Our previous study revealed that increased transcript levels of inflammatory genes (i.e. COX2, EGR1, and SOCS3) coupled with hypomethylation of the promoter regions of these genes was associated with increased DNA damage in arsenic-exposed newborns through their early childhood.	Arsenic	224-231	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-93
35490796-3	2022	This study further investigated the ability of the methyl group donors, S-adenosyl methionine (SAM) and folic acid, to prevent promoter hypomethylation that results in decreased mRNA expression of inflammatory genes (COX2, EGR1, and SOCS3), and a reduction in arsenic-induced oxidative and nitrative DNA damage in human lymphoblast cells.	S-Adenosylmethionine	72-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	217-221
35490796-3	2022	This study further investigated the ability of the methyl group donors, S-adenosyl methionine (SAM) and folic acid, to prevent promoter hypomethylation that results in decreased mRNA expression of inflammatory genes (COX2, EGR1, and SOCS3), and a reduction in arsenic-induced oxidative and nitrative DNA damage in human lymphoblast cells.	S-Adenosylmethionine	95-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	217-221
35490796-3	2022	This study further investigated the ability of the methyl group donors, S-adenosyl methionine (SAM) and folic acid, to prevent promoter hypomethylation that results in decreased mRNA expression of inflammatory genes (COX2, EGR1, and SOCS3), and a reduction in arsenic-induced oxidative and nitrative DNA damage in human lymphoblast cells.	Folic Acid	104-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	217-221
35385597-2	2022	Herein, we report an unprecedented enantioselective C-H functionalization enabled by a simple Co(II)/salicyloxazoline (Salox) catalysis.	salicyloxazoline	101-117	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-100
35385597-2	2022	Herein, we report an unprecedented enantioselective C-H functionalization enabled by a simple Co(II)/salicyloxazoline (Salox) catalysis.	salox)	119-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-100
35453005-7	2022	Young patients, patients dealing with acute pain, or with active and/or chronic symptomatic gastritis, selective COX-2 inhibitors (celecoxib or etoricoxib) may be a better option (level of evidence 2).	Celecoxib	131-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-118
35453005-7	2022	Young patients, patients dealing with acute pain, or with active and/or chronic symptomatic gastritis, selective COX-2 inhibitors (celecoxib or etoricoxib) may be a better option (level of evidence 2).	Etoricoxib	144-154	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-118
35490984-12	2022	RESULTS: We found that the expressions of LIP ROS, ROS, COX2, MDA and other oxidative factors increased, while the antioxidant markers GPX4, GSH and GSH-Px significantly decreased, as well as active iron accumulation in COPD patients, PM-exposured WT and Nrf2-KO mice models and PM2.5-mediated cell models.	Iron	199-203	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-60
35266250-9	2022	The fucoxanthin effectively inhibited the PI3K/Akt/mTOR cascade along with the expression of TNF-alpha, NF-kappaB, Cox-2, and IL-6 and antiapoptotic genes cyclin D1 and Bcl-2 in the HEC-1A cells.	fucoxanthin	4-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-120
35605887-0	2022	Preconception exposure to dibutyl phthalate (DBP) impairs spermatogenesis by activating NF-kappaB/COX-2/RANKL signaling in Sertoli cells.	Dibutyl Phthalate	26-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-103
35605887-0	2022	Preconception exposure to dibutyl phthalate (DBP) impairs spermatogenesis by activating NF-kappaB/COX-2/RANKL signaling in Sertoli cells.	Dibutyl Phthalate	45-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-103
35605887-5	2022	Furthermore, experimental data showed that DBP increased COX-2 and p-p65 expression in Sertoli cells and depleting COX-2 and p-p65 by specific inhibitor NS3-98 and BAY117082 could partially abolish DBP induced up-regulation of RANKL.	ns3-98	153-159	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-62
35605887-5	2022	Furthermore, experimental data showed that DBP increased COX-2 and p-p65 expression in Sertoli cells and depleting COX-2 and p-p65 by specific inhibitor NS3-98 and BAY117082 could partially abolish DBP induced up-regulation of RANKL.	ns3-98	153-159	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-120
35605887-5	2022	Furthermore, experimental data showed that DBP increased COX-2 and p-p65 expression in Sertoli cells and depleting COX-2 and p-p65 by specific inhibitor NS3-98 and BAY117082 could partially abolish DBP induced up-regulation of RANKL.	3-(4-methylphenylsulfonyl)-2-propenenitrile	164-173	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-120
35597858-0	2022	Co(II), Ni(II), and Zn(II) complexes based on new hybrid imine-pyrazole ligands: structural, spectroscopic, and electronic properties.	Imines	57-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
35597858-0	2022	Co(II), Ni(II), and Zn(II) complexes based on new hybrid imine-pyrazole ligands: structural, spectroscopic, and electronic properties.	pyrazole	63-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
35597858-1	2022	The present work reports the theoretical investigation of Co(II), Ni(II), and Zn(II) complexes containing Schiff bases (used as ligands) derived from the reaction of 2-hydroxy-1-naphthaldehyde with N-(2-aminoethyl) pyrazoles.	Schiff Bases	106-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-64
35597858-1	2022	The present work reports the theoretical investigation of Co(II), Ni(II), and Zn(II) complexes containing Schiff bases (used as ligands) derived from the reaction of 2-hydroxy-1-naphthaldehyde with N-(2-aminoethyl) pyrazoles.	2-hydroxy-1-naphthaldehyde	166-192	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-64
35597858-1	2022	The present work reports the theoretical investigation of Co(II), Ni(II), and Zn(II) complexes containing Schiff bases (used as ligands) derived from the reaction of 2-hydroxy-1-naphthaldehyde with N-(2-aminoethyl) pyrazoles.	n-(2-aminoethyl) pyrazoles	198-224	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-64
35188161-2	2022	The fully oxidized ((LN2S2)CoII(CO)FeIICp)+ complex (CoIIFeII, LN2S2 2- = 2,2"-(2,2"-bipyridine-6,6"-diyl)bis(1,1"-diphenylethanethiolate), Cp- = cyclopentadienyl anion) can be (electro)chemically reduced to its CoIFeII form, and both complexes have been isolated and fully characterized by means of classic spectroscopic techniques and theoretical calculations.	(co)feiicp)+	31-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-61
35188161-2	2022	The fully oxidized ((LN2S2)CoII(CO)FeIICp)+ complex (CoIIFeII, LN2S2 2- = 2,2"-(2,2"-bipyridine-6,6"-diyl)bis(1,1"-diphenylethanethiolate), Cp- = cyclopentadienyl anion) can be (electro)chemically reduced to its CoIFeII form, and both complexes have been isolated and fully characterized by means of classic spectroscopic techniques and theoretical calculations.	2,2"-(2,2"-bipyridine-6,6"-diyl)bis(1,1"-diphenylethanethiolate	74-137	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-61
35188161-2	2022	The fully oxidized ((LN2S2)CoII(CO)FeIICp)+ complex (CoIIFeII, LN2S2 2- = 2,2"-(2,2"-bipyridine-6,6"-diyl)bis(1,1"-diphenylethanethiolate), Cp- = cyclopentadienyl anion) can be (electro)chemically reduced to its CoIFeII form, and both complexes have been isolated and fully characterized by means of classic spectroscopic techniques and theoretical calculations.	cyclopentadienyl anion	146-168	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-61
35188161-3	2022	The redox properties of CoIIFeII have been investigated in DMF, revealing that this complex is the easiest to reduce by one-electron among the analogous MFe complexes (M = Ni, Fe, Co).	Dimethylformamide	59-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-32
35188161-3	2022	The redox properties of CoIIFeII have been investigated in DMF, revealing that this complex is the easiest to reduce by one-electron among the analogous MFe complexes (M = Ni, Fe, Co).	mfe	153-156	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-32
35188161-3	2022	The redox properties of CoIIFeII have been investigated in DMF, revealing that this complex is the easiest to reduce by one-electron among the analogous MFe complexes (M = Ni, Fe, Co).	Iron	176-178	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-32
35188161-3	2022	The redox properties of CoIIFeII have been investigated in DMF, revealing that this complex is the easiest to reduce by one-electron among the analogous MFe complexes (M = Ni, Fe, Co).	Cobalt	180-182	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-32
35506986-2	2022	The total synthesis of 7 members of the acyloin family was achieved via a HWE reaction followed by Mukaiyama-Isayama hydration, using novel Co(II) and Co(III) Schiff base SALPN complexes as catalysts for the key enone hydration step.	enone	212-217	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-146
35585779-3	2022	Identification of two isoforms of COX, COX-1 and COX-2, led to the development of selective COX-2 inhibitors which were launched as having fewer gastrointestinal side effects since gastroprotective prostaglandins produced via COX-1 are spared.	Prostaglandins	198-212	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-97
35585779-4	2022	The balance between COX-1 mediated prothrombotic thromboxane and COX-2 mediated antithrombotic prostacyclin is important for thrombotic risk.	Epoprostenol	95-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-70
35506535-0	2022	Magnetic anisotropy of two tetrahedral Co(II)-halide complexes with triphenylphosphine ligands.	triphenylphosphine	68-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-45
35585779-6	2022	Rofecoxib (Vioxx) was withdrawn from the market for this reason, but the equally COX-2 selective etoricoxib has replaced it in Europe but not in the US.	Etoricoxib	97-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-86
35506535-2	2022	To find out the influence of the coordination environment on SIMs, two four-coordinate mononuclear Co(II) complexes (NEt4)(Co(PPh3)X3) (X = Cl-, 1; Br-, 2) have been synthesized and studied by X-ray single crystallography, magnetic measurements, high-frequency and -field EPR (HF-EPR) spectroscopy and theoretical calculations.	co(pph3)	123-131	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-105
35585779-7	2022	The "traditional" NSAID diclofenac is as COX-2 selective as celecoxib and increases cardiovascular risk dose-dependently.	Diclofenac	24-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-46
35585779-7	2022	The "traditional" NSAID diclofenac is as COX-2 selective as celecoxib and increases cardiovascular risk dose-dependently.	Celecoxib	60-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-46
35585779-9	2022	Randomized trials comparing COX-2 inhibitors with NSAIDs have exaggerated their gastrointestinal benefits by using maximal NSAID doses regardless of indication, and/or hidden the cardiovascular risk by comparing with COX-2 selective diclofenac instead of low-dose ibuprofen or naproxen.	Ibuprofen	264-273	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
35585779-9	2022	Randomized trials comparing COX-2 inhibitors with NSAIDs have exaggerated their gastrointestinal benefits by using maximal NSAID doses regardless of indication, and/or hidden the cardiovascular risk by comparing with COX-2 selective diclofenac instead of low-dose ibuprofen or naproxen.	Naproxen	277-285	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
35628301-3	2022	Volumetric (oxygenation) studies were carried out to determine the uptake of molecular oxygen O2 in the formation of the complexes Co(II)-Hpop and Co(II)-Hpoa.	Oxygen	87-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-153
35570193-0	2022	Layered Uranyl Phosphonates Encapsulating Co(II)/Mn(II)/Zn(II) Ions: Exfoliation into Nanosheets and Its Impact on Magnetic and Luminescent Properties.	uranyl phosphonates	8-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-48
35570193-2	2022	Herein we report three heterobimetallic uranyl phosphonates, namely, ((UO2)3M(2-pmbH)4(H2O)4) 2H2O (MU, M = Co(II), CoU; Mn(II), MnU; Zn(II), ZnU; 2-pmbH3 = 2-(phosphonomethyl)benzoic acid).	heterobimetallic uranyl phosphonates	23-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-114
35570193-2	2022	Herein we report three heterobimetallic uranyl phosphonates, namely, ((UO2)3M(2-pmbH)4(H2O)4) 2H2O (MU, M = Co(II), CoU; Mn(II), MnU; Zn(II), ZnU; 2-pmbH3 = 2-(phosphonomethyl)benzoic acid).	Water	87-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-114
35628301-0	2022	Oxygen Binding by Co(II) Complexes with Oxime-Containing Schiff Bases in Solution.	Oxygen	0-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-24
35628301-3	2022	Volumetric (oxygenation) studies were carried out to determine the uptake of molecular oxygen O2 in the formation of the complexes Co(II)-Hpop and Co(II)-Hpoa.	Oxygen	94-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-153
35628301-0	2022	Oxygen Binding by Co(II) Complexes with Oxime-Containing Schiff Bases in Solution.	Oximes	40-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-24
35628301-0	2022	Oxygen Binding by Co(II) Complexes with Oxime-Containing Schiff Bases in Solution.	Schiff Bases	57-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-24
35442647-1	2022	Rapid generation of high-valent cobalt-oxo species (Co(IV) O) for the removal of organic contaminants has been challenging because of the low conversion efficiency of Co(III)/Co(II) and the high activation energy barrier of the Co(II)-oxidant complex.	cobalt-oxo species	32-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	175-181
35441670-4	2022	Our aims were to compare the effects of low-dose (COX-1 inhibition) and high-dose (dual COX-1 and COX-2 inhibition) aspirin on blood pressure, vascular function, oxidative stress, ET-1 and prostanoid levels and kidney damage during angiogenesis inhibitor therapy in rodents.	Aspirin	116-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-103
35466675-0	2022	Synthesis and Magnetic Properties of Antimony-Ligated Co(II) Complexes: Stibines versus Phosphines.	stibine	72-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-60
35466675-0	2022	Synthesis and Magnetic Properties of Antimony-Ligated Co(II) Complexes: Stibines versus Phosphines.	Phosphines	88-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-60
35477280-1	2022	A new porous metal-organic framework, (Co (oba) (bpdh)) (DMF) (TMU-63), containing accessible nitrogen-rich diazahexadiene groups was successfully prepared with the solvothermal assembly of 5-bis(4-pyridyl)-3,4-diaza-2,4-hexadiene (4-bpdh), 4,4"-oxybis(benzoic) acid (oba), and Co(II) ions.	Metals	13-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	278-284
35477280-1	2022	A new porous metal-organic framework, (Co (oba) (bpdh)) (DMF) (TMU-63), containing accessible nitrogen-rich diazahexadiene groups was successfully prepared with the solvothermal assembly of 5-bis(4-pyridyl)-3,4-diaza-2,4-hexadiene (4-bpdh), 4,4"-oxybis(benzoic) acid (oba), and Co(II) ions.	co (oba)	39-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	278-284
35477280-1	2022	A new porous metal-organic framework, (Co (oba) (bpdh)) (DMF) (TMU-63), containing accessible nitrogen-rich diazahexadiene groups was successfully prepared with the solvothermal assembly of 5-bis(4-pyridyl)-3,4-diaza-2,4-hexadiene (4-bpdh), 4,4"-oxybis(benzoic) acid (oba), and Co(II) ions.	bpdh))	49-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	278-284
35477280-1	2022	A new porous metal-organic framework, (Co (oba) (bpdh)) (DMF) (TMU-63), containing accessible nitrogen-rich diazahexadiene groups was successfully prepared with the solvothermal assembly of 5-bis(4-pyridyl)-3,4-diaza-2,4-hexadiene (4-bpdh), 4,4"-oxybis(benzoic) acid (oba), and Co(II) ions.	Dimethylformamide	57-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	278-284
35477280-1	2022	A new porous metal-organic framework, (Co (oba) (bpdh)) (DMF) (TMU-63), containing accessible nitrogen-rich diazahexadiene groups was successfully prepared with the solvothermal assembly of 5-bis(4-pyridyl)-3,4-diaza-2,4-hexadiene (4-bpdh), 4,4"-oxybis(benzoic) acid (oba), and Co(II) ions.	1,1,3,3-tetramethylurea	63-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	278-284
35477280-1	2022	A new porous metal-organic framework, (Co (oba) (bpdh)) (DMF) (TMU-63), containing accessible nitrogen-rich diazahexadiene groups was successfully prepared with the solvothermal assembly of 5-bis(4-pyridyl)-3,4-diaza-2,4-hexadiene (4-bpdh), 4,4"-oxybis(benzoic) acid (oba), and Co(II) ions.	Nitrogen	94-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	278-284
35477280-1	2022	A new porous metal-organic framework, (Co (oba) (bpdh)) (DMF) (TMU-63), containing accessible nitrogen-rich diazahexadiene groups was successfully prepared with the solvothermal assembly of 5-bis(4-pyridyl)-3,4-diaza-2,4-hexadiene (4-bpdh), 4,4"-oxybis(benzoic) acid (oba), and Co(II) ions.	diazahexadiene	108-122	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	278-284
35477280-1	2022	A new porous metal-organic framework, (Co (oba) (bpdh)) (DMF) (TMU-63), containing accessible nitrogen-rich diazahexadiene groups was successfully prepared with the solvothermal assembly of 5-bis(4-pyridyl)-3,4-diaza-2,4-hexadiene (4-bpdh), 4,4"-oxybis(benzoic) acid (oba), and Co(II) ions.	5-bis(4-pyridyl)-3,4-diaza-2,4-hexadiene	190-230	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	278-284
35477280-1	2022	A new porous metal-organic framework, (Co (oba) (bpdh)) (DMF) (TMU-63), containing accessible nitrogen-rich diazahexadiene groups was successfully prepared with the solvothermal assembly of 5-bis(4-pyridyl)-3,4-diaza-2,4-hexadiene (4-bpdh), 4,4"-oxybis(benzoic) acid (oba), and Co(II) ions.	4-bpdh	232-238	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	278-284
35477280-1	2022	A new porous metal-organic framework, (Co (oba) (bpdh)) (DMF) (TMU-63), containing accessible nitrogen-rich diazahexadiene groups was successfully prepared with the solvothermal assembly of 5-bis(4-pyridyl)-3,4-diaza-2,4-hexadiene (4-bpdh), 4,4"-oxybis(benzoic) acid (oba), and Co(II) ions.	4,4"-oxybis(benzoic) acid	241-266	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	278-284
35477280-1	2022	A new porous metal-organic framework, (Co (oba) (bpdh)) (DMF) (TMU-63), containing accessible nitrogen-rich diazahexadiene groups was successfully prepared with the solvothermal assembly of 5-bis(4-pyridyl)-3,4-diaza-2,4-hexadiene (4-bpdh), 4,4"-oxybis(benzoic) acid (oba), and Co(II) ions.	2-(oxaloamino)benzoic acid	268-271	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	278-284
35476545-2	2022	The triple catalysis realizes three key elementary steps in a single catalytic cycle: (1) Co(III) hydride generation by photochemical reduction of Co(II) followed by protonation, (2) metal hydride hydrogen atom transfer (MHAT) of alkenes by Co(III) hydride, and (3) oxidation of the alkyl Co(III) complex to alkyl Co(IV).	co(iii)	90-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-153
35476545-2	2022	The triple catalysis realizes three key elementary steps in a single catalytic cycle: (1) Co(III) hydride generation by photochemical reduction of Co(II) followed by protonation, (2) metal hydride hydrogen atom transfer (MHAT) of alkenes by Co(III) hydride, and (3) oxidation of the alkyl Co(III) complex to alkyl Co(IV).	Alkenes	230-237	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-153
35476545-2	2022	The triple catalysis realizes three key elementary steps in a single catalytic cycle: (1) Co(III) hydride generation by photochemical reduction of Co(II) followed by protonation, (2) metal hydride hydrogen atom transfer (MHAT) of alkenes by Co(III) hydride, and (3) oxidation of the alkyl Co(III) complex to alkyl Co(IV).	co(iii) hydride	241-256	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-153
35476545-2	2022	The triple catalysis realizes three key elementary steps in a single catalytic cycle: (1) Co(III) hydride generation by photochemical reduction of Co(II) followed by protonation, (2) metal hydride hydrogen atom transfer (MHAT) of alkenes by Co(III) hydride, and (3) oxidation of the alkyl Co(III) complex to alkyl Co(IV).	co(iii)	289-296	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-153
35476545-2	2022	The triple catalysis realizes three key elementary steps in a single catalytic cycle: (1) Co(III) hydride generation by photochemical reduction of Co(II) followed by protonation, (2) metal hydride hydrogen atom transfer (MHAT) of alkenes by Co(III) hydride, and (3) oxidation of the alkyl Co(III) complex to alkyl Co(IV).	alkyl	308-313	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-153
35476545-2	2022	The triple catalysis realizes three key elementary steps in a single catalytic cycle: (1) Co(III) hydride generation by photochemical reduction of Co(II) followed by protonation, (2) metal hydride hydrogen atom transfer (MHAT) of alkenes by Co(III) hydride, and (3) oxidation of the alkyl Co(III) complex to alkyl Co(IV).	co(iv)	314-320	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-153
35600595-9	2022	Mechanically, C/EBPalpha bounded to the promoter region of COX-2 and increased the transcriptional activity under the stimulation of hCG or db-cAMP.	Bucladesine	140-147	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-64
35121582-0	2022	The COX-2-PGE2 pathway promotes tumor evasion in colorectal adenomas.	Dinoprostone	10-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
35442647-1	2022	Rapid generation of high-valent cobalt-oxo species (Co(IV) O) for the removal of organic contaminants has been challenging because of the low conversion efficiency of Co(III)/Co(II) and the high activation energy barrier of the Co(II)-oxidant complex.	cobalt-oxo species	32-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	228-234
35442647-1	2022	Rapid generation of high-valent cobalt-oxo species (Co(IV) O) for the removal of organic contaminants has been challenging because of the low conversion efficiency of Co(III)/Co(II) and the high activation energy barrier of the Co(II)-oxidant complex.	co(iv) o	52-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	175-181
35442647-1	2022	Rapid generation of high-valent cobalt-oxo species (Co(IV) O) for the removal of organic contaminants has been challenging because of the low conversion efficiency of Co(III)/Co(II) and the high activation energy barrier of the Co(II)-oxidant complex.	co(iv) o	52-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	228-234
35442647-3	2022	These N vacancies enhanced the electron distribution of the Co 3d orbital and lowered the energy barrier to cleave the O-O bond of PMS in the Co(II)-PMS complex, achieving the modulation of major active species from 1O2 to Co(IV) O.	Nitrogen	6-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	142-148
35448899-2	2022	In proof-of-concept studies, M-CPOnes based on ZnII, FeII and CoII are stable in the dark but undergo light-triggered CO release with the cyclopropenone substituents and metal ions enabling tuning of the photophysical properties.	m-cpones	29-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-66
35448899-2	2022	In proof-of-concept studies, M-CPOnes based on ZnII, FeII and CoII are stable in the dark but undergo light-triggered CO release with the cyclopropenone substituents and metal ions enabling tuning of the photophysical properties.	Metals	170-175	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-66
35566202-0	2022	Antiinflammation Derived Suzuki-Coupled Fenbufens as COX-2 Inhibitors: Minilibrary Construction and Bioassay.	fenbufen	40-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-58
35040067-4	2022	The results showed that hollow cobalt-based ferrocenyl metal-organic framework microspheres (Co-Fc-MOFs) exhibited the best catalytic performance, which is closely related to the synergy of Fc/Fc+ and Co(II)/Co(III) cycles in persulfate activation.	Cobalt	31-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	201-207
35040067-4	2022	The results showed that hollow cobalt-based ferrocenyl metal-organic framework microspheres (Co-Fc-MOFs) exhibited the best catalytic performance, which is closely related to the synergy of Fc/Fc+ and Co(II)/Co(III) cycles in persulfate activation.	co(iii)	208-215	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	201-207
35040067-4	2022	The results showed that hollow cobalt-based ferrocenyl metal-organic framework microspheres (Co-Fc-MOFs) exhibited the best catalytic performance, which is closely related to the synergy of Fc/Fc+ and Co(II)/Co(III) cycles in persulfate activation.	Peroxydisulfate	226-236	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	201-207
35119637-8	2022	The effective parameters underlying the anticancer effects of naringenin and naringin include GSK3beta inactivation, suppression of the gene and protein activation of NF-kB and COX-2, JAK2/STAT3 downregulation, downregulation of intracellular adhesion molecules-1, upregulation of Notch1 and tyrocite-specific genes, and activation of p38/MAPK and caspase-3.	naringenin	62-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	177-182
35119637-8	2022	The effective parameters underlying the anticancer effects of naringenin and naringin include GSK3beta inactivation, suppression of the gene and protein activation of NF-kB and COX-2, JAK2/STAT3 downregulation, downregulation of intracellular adhesion molecules-1, upregulation of Notch1 and tyrocite-specific genes, and activation of p38/MAPK and caspase-3.	naringin	77-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	177-182
35490158-0	2022	Correction: Aiphanol, a native compound, suppresses angiogenesis via dual-targeting VEGFR2 and COX2.	aiphanol	12-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-99
35566202-4	2022	Both the para-amino and para-hydroxy mono substituents display the most substantial COX-2 inhibition, particularly the latter one showing a comparable activity as celecoxib.	-amino	13-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-89
35566202-4	2022	Both the para-amino and para-hydroxy mono substituents display the most substantial COX-2 inhibition, particularly the latter one showing a comparable activity as celecoxib.	-hydroxy	28-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-89
35566202-5	2022	The most COX-2 selective and bioactive disubstituted compound encompasses one electron-withdrawing methyl and one electron-donating fluoro groups in one arene.	arene	153-158	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	9-14
35566202-7	2022	In silico simulation and modeling for three COX-2 active-p-fluoro, p-hydroxy and p-amino-fenbufens show a preferable docking to COX-2 than COX-1.	p-hydroxy	67-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-49
35566202-7	2022	In silico simulation and modeling for three COX-2 active-p-fluoro, p-hydroxy and p-amino-fenbufens show a preferable docking to COX-2 than COX-1.	p-hydroxy	67-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	128-133
35566202-7	2022	In silico simulation and modeling for three COX-2 active-p-fluoro, p-hydroxy and p-amino-fenbufens show a preferable docking to COX-2 than COX-1.	p-amino-fenbufens	81-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-49
35566202-7	2022	In silico simulation and modeling for three COX-2 active-p-fluoro, p-hydroxy and p-amino-fenbufens show a preferable docking to COX-2 than COX-1.	p-amino-fenbufens	81-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	128-133
35566202-8	2022	The most stabilization by the p-hydroxy fenbufen with COX-2 predicted by theoretical simulation is consistent with its prominent COX-2 inhibition resulting from experiments.	p-hydroxy fenbufen	30-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-59
35566202-8	2022	The most stabilization by the p-hydroxy fenbufen with COX-2 predicted by theoretical simulation is consistent with its prominent COX-2 inhibition resulting from experiments.	p-hydroxy fenbufen	30-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-134
35417163-2	2022	Strong antiferromagnetic interactions between Co(II) ions mediated by the 2mIm ligands lead to antiferromagnetic ordering at 22 K. Postsynthetic treatment of Co(II) ZIF-67 with 5-methyltetrazole (5mT) results in the loss of crystallinity and magnetic order.	5-Methyltetrazole	177-194	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-52
35566952-0	2022	Calcined Co(II)-Chelated Polyazomethine as Cathode Catalyst of Anion Exchange Membrane Fuel Cells.	polyazomethine	25-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	9-15
35417163-1	2022	Reaction of Co(II) nitrate with 2-methylimidazole (2mIm) yields ZIF-67, the structure of which features Co(II) ions in pseudo-tetrahedral coordination geometry.	2-methylimidazole	32-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-18
35475313-3	2022	Moreover, the characteristic spectrum of Co(II) ion makes it a powerful probe for the characterization of metal-binding proteins through the formation of cobalt-ligand bonds.	Metals	106-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-47
35475313-3	2022	Moreover, the characteristic spectrum of Co(II) ion makes it a powerful probe for the characterization of metal-binding proteins through the formation of cobalt-ligand bonds.	Cobalt	154-160	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-47
35475313-5	2022	To prove this, we used atomic force microscopy-based single-molecule force spectroscopy (AFM-SMFS) to directly measure the rupture force of Co(II)-thiolate bond in Co-substituted rubredoxin (CoRD).	thiolate	147-155	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-146
35475313-7	2022	Thus, we quantified the strength of Co(II)-thiolate bonds in rubredoxin with a rupture force of ~140 pN, revealing that it is a mechanostable chemical bond.	thiolate	43-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-42
35417163-1	2022	Reaction of Co(II) nitrate with 2-methylimidazole (2mIm) yields ZIF-67, the structure of which features Co(II) ions in pseudo-tetrahedral coordination geometry.	2-methylimidazole	32-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-110
35417163-2	2022	Strong antiferromagnetic interactions between Co(II) ions mediated by the 2mIm ligands lead to antiferromagnetic ordering at 22 K. Postsynthetic treatment of Co(II) ZIF-67 with 5-methyltetrazole (5mT) results in the loss of crystallinity and magnetic order.	5-Methyltetrazole	177-194	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	158-164
35175765-4	2022	Interestingly, the alpha-amyrin derivatives were the most potent inhibitors of COX-2, but inhibited COX-1 only to some extent.	beta-amyrin	19-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-84
35229489-0	2022	Molecular Engineering of CoII Porphyrins with Asymmetric Architecture for Improved Electrochemical CO2 Reduction.	Carbon Dioxide	99-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-29
35229489-4	2022	In this work, a series of CoII porphyrins (PorCos) with symmetric and asymmetric substituents were used as model of molecular catalysts for CO2 reduction.	Carbon Dioxide	140-143	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-30
35229489-7	2022	Among the three molecules, asymmetric CoII porphyrin (as-PorCo) showed the lowest onset potential of -288 mV and faradaic efficiencies exceeding 93 % at -0.6 V vs. reversible hydrogen electrode, which is highly competitive among the reported state-of-art porphyrin-based electrocatalysts.	as-porco	54-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-42
35229489-7	2022	Among the three molecules, asymmetric CoII porphyrin (as-PorCo) showed the lowest onset potential of -288 mV and faradaic efficiencies exceeding 93 % at -0.6 V vs. reversible hydrogen electrode, which is highly competitive among the reported state-of-art porphyrin-based electrocatalysts.	Hydrogen	175-183	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-42
35229489-7	2022	Among the three molecules, asymmetric CoII porphyrin (as-PorCo) showed the lowest onset potential of -288 mV and faradaic efficiencies exceeding 93 % at -0.6 V vs. reversible hydrogen electrode, which is highly competitive among the reported state-of-art porphyrin-based electrocatalysts.	Porphyrins	255-264	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-42
35175765-0	2022	Synthesis, Biological Evaluation, and Molecular Docking Study of 3-Amino and 3-Hydroxy-seco A Derivatives of alpha-Amyrin and 3-Epilupeol as Inhibitors of COX-2 Activity and NF-kB Activation.	3-amino and 3-hydroxy-seco a	65-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	155-160
35175765-0	2022	Synthesis, Biological Evaluation, and Molecular Docking Study of 3-Amino and 3-Hydroxy-seco A Derivatives of alpha-Amyrin and 3-Epilupeol as Inhibitors of COX-2 Activity and NF-kB Activation.	beta-amyrin	109-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	155-160
35175765-0	2022	Synthesis, Biological Evaluation, and Molecular Docking Study of 3-Amino and 3-Hydroxy-seco A Derivatives of alpha-Amyrin and 3-Epilupeol as Inhibitors of COX-2 Activity and NF-kB Activation.	Epilupeol	126-137	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	155-160
35566053-0	2022	Antitumor Activity and Physicochemical Properties of New Thiosemicarbazide Derivative and Its Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) Complexes.	thiosemicarbazide	57-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-100
35175765-6	2022	Molecular docking studies revealed that these compounds bind with their polar region in the cavity over Arg-120, and their lipophilic part is orientated to the HEM cofactor similarly to the natural substrate arachidonic acid in the catalytic site of COX-2.	Arginine	104-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	250-255
35175765-6	2022	Molecular docking studies revealed that these compounds bind with their polar region in the cavity over Arg-120, and their lipophilic part is orientated to the HEM cofactor similarly to the natural substrate arachidonic acid in the catalytic site of COX-2.	Arachidonic Acid	208-224	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	250-255
35175765-7	2022	These results indicated that seco-A ursane derivatives could be considered promising candidates for the future development of selective NF-kappaB and COX-2 inhibitors.	seco-a ursane	29-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	150-155
35394751-6	2022	In addition, more reactive Co(II) with the closer d-band center to the Fermi level results in higher electron transfer efficiency and lower decomposition energy of PMS to SO4 -.	peroxymonosulfate	164-167	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-33
35172039-2	2022	Herein, we demonstrate the synthesis of a Co II diketimide complex (( Tr L)Co(NC 6 F 5 )) 2 and its reversible C-C bond cleavage to yield a monomeric Co nitrenoid complex ( Tr L)Co(NC 6 F 5 ).	co(	75-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47
35172039-2	2022	Herein, we demonstrate the synthesis of a Co II diketimide complex (( Tr L)Co(NC 6 F 5 )) 2 and its reversible C-C bond cleavage to yield a monomeric Co nitrenoid complex ( Tr L)Co(NC 6 F 5 ).	Carbon	111-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47
35172039-2	2022	Herein, we demonstrate the synthesis of a Co II diketimide complex (( Tr L)Co(NC 6 F 5 )) 2 and its reversible C-C bond cleavage to yield a monomeric Co nitrenoid complex ( Tr L)Co(NC 6 F 5 ).	Carbon	113-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47
35172039-2	2022	Herein, we demonstrate the synthesis of a Co II diketimide complex (( Tr L)Co(NC 6 F 5 )) 2 and its reversible C-C bond cleavage to yield a monomeric Co nitrenoid complex ( Tr L)Co(NC 6 F 5 ).	co nitrenoid	150-162	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47
35394751-6	2022	In addition, more reactive Co(II) with the closer d-band center to the Fermi level results in higher electron transfer efficiency and lower decomposition energy of PMS to SO4 -.	sulfuric acid	171-174	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-33
35440553-3	2022	Here, we show that cytotoxic therapy acutely upregulates cyclooxygenase (COX)-2 expression and prostaglandin E2 (PGE2) production in cancer cells with pre-existing COX-2 activity.	Dinoprostone	95-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	164-169
35440553-3	2022	Here, we show that cytotoxic therapy acutely upregulates cyclooxygenase (COX)-2 expression and prostaglandin E2 (PGE2) production in cancer cells with pre-existing COX-2 activity.	Dinoprostone	113-117	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	164-169
35440553-5	2022	Genetic manipulation of COX-2 expression or its gene promoter region uncover how augmented COX-2/PGE2 activity post-treatment profoundly alters the inflammatory properties of chemotherapy-treated cancer cells in vivo.	Dinoprostone	97-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
35440553-5	2022	Genetic manipulation of COX-2 expression or its gene promoter region uncover how augmented COX-2/PGE2 activity post-treatment profoundly alters the inflammatory properties of chemotherapy-treated cancer cells in vivo.	Dinoprostone	97-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-96
35440553-8	2022	Our findings suggest COX-2/PGE2 upregulation by dying cancer cells acts as a major barrier to cytotoxic therapy-driven tumor immunity and uncover a strategy to improve the outcomes of immunotherapy and chemotherapy combinations.	Dinoprostone	27-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-26
35497094-10	2022	Thrombin promoted phosphorylation of NF-kappaB p65, leading to nuclear translocation and binding to the COX-2 promoter element to enhance promoter activity, which was reduced by Go6976, SP600125, SB202190, or U0126.	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	196-204	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
35497094-3	2022	However, in human tracheal smooth muscle cells (HTSMCs), how thrombin enhanced the levels of COX-2/PGE2 is not completely characterized.	Dinoprostone	99-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-98
35077983-1	2022	In this work, herein we report the synthesis, structural characterization and in vitro cytotoxic evaluation of two mixed Co(II)/Ni(II)-nalidixic acid-bipyridyl complexes (1 and 2).	nalidixic acid-bipyridyl complexes	135-169	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-127
35497094-10	2022	Thrombin promoted phosphorylation of NF-kappaB p65, leading to nuclear translocation and binding to the COX-2 promoter element to enhance promoter activity, which was reduced by Go6976, SP600125, SB202190, or U0126.	Go 6976	178-184	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
35497094-10	2022	Thrombin promoted phosphorylation of NF-kappaB p65, leading to nuclear translocation and binding to the COX-2 promoter element to enhance promoter activity, which was reduced by Go6976, SP600125, SB202190, or U0126.	pyrazolanthrone	186-194	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
35430637-8	2022	Western blot analysis revealed that melatonin downregulated the expression of pro-inflammatory transcription factor, NF-kappaB and the expression of COX-2 protein, a key mediator in cell proliferation.	Melatonin	36-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	149-154
35077983-0	2022	Mixed Ni(II) and Co(II) complexes of nalidixic acid drug: Synthesis, characterization, DNA/BSA binding profile and in vitro cytotoxic evaluation against MDA-MB-231 and HepG2 cancer cell lines.	Nalidixic Acid	37-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-23
35077983-1	2022	In this work, herein we report the synthesis, structural characterization and in vitro cytotoxic evaluation of two mixed Co(II)/Ni(II)-nalidixic acid-bipyridyl complexes (1 and 2).	Nickel(2+)	128-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-127
35497094-10	2022	Thrombin promoted phosphorylation of NF-kappaB p65, leading to nuclear translocation and binding to the COX-2 promoter element to enhance promoter activity, which was reduced by Go6976, SP600125, SB202190, or U0126.	U 0126	209-214	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
35497094-11	2022	These findings supported that COX-2/PGE2 expression triggered by thrombin was engaged in PAR1/Gq or Gi/o/PKCalpha/MAPK-dependent NF-kappaB activation in HTSMCs.	Dinoprostone	36-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-35
35429006-0	2022	New pyrimidine/thiazole hybrids endowed with analgesic, anti-inflammatory, and lower cardiotoxic activities: Design, synthesis, and COX-2/sEH dual inhibition.	pyrimidine	4-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-137
35429006-0	2022	New pyrimidine/thiazole hybrids endowed with analgesic, anti-inflammatory, and lower cardiotoxic activities: Design, synthesis, and COX-2/sEH dual inhibition.	Thiazoles	15-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-137
35456686-7	2022	Furthermore, the produced RSV-PCL microparticles reduced the expression of inflammatory (IL-6, IL-8, COX-2) and proteolytic (MMP-2, MMP-9) mediators.	rsv-pcl	26-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-106
35364808-1	2022	An enantiopure ligand with four bidentate metal-binding sites and four (S)-carbon stereocenters self-assembles with octahedral ZnII or CoII to produce O-symmetric M8L6 coordination cages.	Metals	42-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-139
35364808-1	2022	An enantiopure ligand with four bidentate metal-binding sites and four (S)-carbon stereocenters self-assembles with octahedral ZnII or CoII to produce O-symmetric M8L6 coordination cages.	Carbon	75-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-139
35396529-4	2022	Both soluble factors and direct-cell contact interactions, such as JAG/NOTCH and COX-2/PGE2 pathways, are critically involved in the HSC-monocyte crosstalk.	Dinoprostone	87-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-86
35413817-0	2022	COX-2 strengthens the effects of acid and bile salts on human esophageal cells and Barrett esophageal cells.	Bile Acids and Salts	42-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
35358381-2	2022	Monomeric aromatic tetrapyrroles (such as porphyrins, phthalocyanines, and corroles) coordinated to Co(II) or Co(III) have been considered as oxygen reduction catalysts due to their low cost and relative ease of synthesis.	aromatic tetrapyrroles	10-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-106
35358381-2	2022	Monomeric aromatic tetrapyrroles (such as porphyrins, phthalocyanines, and corroles) coordinated to Co(II) or Co(III) have been considered as oxygen reduction catalysts due to their low cost and relative ease of synthesis.	Porphyrins	42-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-106
35358381-2	2022	Monomeric aromatic tetrapyrroles (such as porphyrins, phthalocyanines, and corroles) coordinated to Co(II) or Co(III) have been considered as oxygen reduction catalysts due to their low cost and relative ease of synthesis.	phthalocyanine	54-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-106
35358381-2	2022	Monomeric aromatic tetrapyrroles (such as porphyrins, phthalocyanines, and corroles) coordinated to Co(II) or Co(III) have been considered as oxygen reduction catalysts due to their low cost and relative ease of synthesis.	corrole	75-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-106
35358381-2	2022	Monomeric aromatic tetrapyrroles (such as porphyrins, phthalocyanines, and corroles) coordinated to Co(II) or Co(III) have been considered as oxygen reduction catalysts due to their low cost and relative ease of synthesis.	Oxygen	142-148	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-106
35358381-4	2022	Herein, we report the initial synthesis and study of a Co(II) tetrapyrrole complex based on a nonaromatic isocorrole scaffold that is competent for 4e-/4H+ oxygen reduction reaction (ORR).	isocorrole	106-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-61
35358381-4	2022	Herein, we report the initial synthesis and study of a Co(II) tetrapyrrole complex based on a nonaromatic isocorrole scaffold that is competent for 4e-/4H+ oxygen reduction reaction (ORR).	4e	148-150	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-61
35358381-4	2022	Herein, we report the initial synthesis and study of a Co(II) tetrapyrrole complex based on a nonaromatic isocorrole scaffold that is competent for 4e-/4H+ oxygen reduction reaction (ORR).	4h	152-154	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-61
35358381-4	2022	Herein, we report the initial synthesis and study of a Co(II) tetrapyrrole complex based on a nonaromatic isocorrole scaffold that is competent for 4e-/4H+ oxygen reduction reaction (ORR).	Oxygen	156-162	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-61
35358381-7	2022	Further, the investigation of the ORR activity of Co(10-DMIC) using a combination of electrochemical and chemical reduction studies revealed that this simple, unadorned monomeric Co(II) tetrapyrrole is ~85% selective for the 4e-/4H+ reduction of O2 to H2O over the more kinetically facile 2e-/2H+ process that delivers H2O2.	co(10-dmic)	50-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	179-185
35358381-7	2022	Further, the investigation of the ORR activity of Co(10-DMIC) using a combination of electrochemical and chemical reduction studies revealed that this simple, unadorned monomeric Co(II) tetrapyrrole is ~85% selective for the 4e-/4H+ reduction of O2 to H2O over the more kinetically facile 2e-/2H+ process that delivers H2O2.	4e	225-227	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	179-185
35358381-7	2022	Further, the investigation of the ORR activity of Co(10-DMIC) using a combination of electrochemical and chemical reduction studies revealed that this simple, unadorned monomeric Co(II) tetrapyrrole is ~85% selective for the 4e-/4H+ reduction of O2 to H2O over the more kinetically facile 2e-/2H+ process that delivers H2O2.	4h	229-231	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	179-185
35358381-7	2022	Further, the investigation of the ORR activity of Co(10-DMIC) using a combination of electrochemical and chemical reduction studies revealed that this simple, unadorned monomeric Co(II) tetrapyrrole is ~85% selective for the 4e-/4H+ reduction of O2 to H2O over the more kinetically facile 2e-/2H+ process that delivers H2O2.	Oxygen	246-248	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	179-185
35358381-7	2022	Further, the investigation of the ORR activity of Co(10-DMIC) using a combination of electrochemical and chemical reduction studies revealed that this simple, unadorned monomeric Co(II) tetrapyrrole is ~85% selective for the 4e-/4H+ reduction of O2 to H2O over the more kinetically facile 2e-/2H+ process that delivers H2O2.	Water	252-255	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	179-185
35358381-7	2022	Further, the investigation of the ORR activity of Co(10-DMIC) using a combination of electrochemical and chemical reduction studies revealed that this simple, unadorned monomeric Co(II) tetrapyrrole is ~85% selective for the 4e-/4H+ reduction of O2 to H2O over the more kinetically facile 2e-/2H+ process that delivers H2O2.	Deuterium	293-295	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	179-185
35358381-7	2022	Further, the investigation of the ORR activity of Co(10-DMIC) using a combination of electrochemical and chemical reduction studies revealed that this simple, unadorned monomeric Co(II) tetrapyrrole is ~85% selective for the 4e-/4H+ reduction of O2 to H2O over the more kinetically facile 2e-/2H+ process that delivers H2O2.	Hydrogen Peroxide	319-323	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	179-185
35389917-2	2022	Selective cyclooxygenase (COX)-2 inhibitors (e.g., celecoxib) are believed to have fewer gastrointestinal (GI) adverse effects than nonselective NSAIDS.	Celecoxib	51-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-32
35378654-6	2022	The extent of recovery in biomass, when the supply of Co(II) metal ion was discontinued in the inlet stream, was explored.	Metals	61-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-60
35389917-3	2022	Meloxicam is less selective for COX-2 than celecoxib is and partially inhibits COX-1 at higher doses.	Meloxicam	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-37
35286533-7	2022	Moreover, captopril significantly reduced the inflammation markers including NF-kB, IL-1 beta, COX-1, and COX-2 levels.	Captopril	10-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-111
35218740-8	2022	Moreover, Ang II-induced COX-2-mediated PGE2 secretion was also inhibited by the pretreatment with CORM-2.	Dinoprostone	40-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-30
35373257-4	2022	Celecoxib is a selective inhibitor of COX-2.	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-43
35373258-2	2022	Importantly, both decrease of PD-L1 expression and increase of CD8+ T cells were associated with the inhibition of COX-2/PGE2 pathway in vitro and syngeneic colonic tumor xenograft models.	Dinoprostone	121-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-120
35373259-3	2022	Compared with colorectal cancer, the role of aspirin in gastric cancer prevention is less well described, however it stands to reason that aspirin and/or other nonsteroidal anti-inflammatory drugs may inhibit gastric cancer progression through the inhibition of COX-2.	Aspirin	139-146	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	262-267
35000048-0	2022	COX-1, COX-2 and CYP2C19 variations may be related to cardiovascular events due to acetylsalicylic acid resistance.	Aspirin	83-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	7-12
35114479-1	2022	New binuclear Co(II) (1), Ni(II) (2) and Cu(II) (3) complexes of N,N"-(2,2"-azanediylbis(ethane-2,1-diyl))bis(2-aminobenzamide) have been synthesized and fully characterized by various chemical and spectral techniques.	n,n"-(2,2"-azanediylbis(ethane-2,1-diyl))bis(2-aminobenzamide	65-126	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-20
35571660-0	2022	Inhibitory effect of lovastatin on human lung cancer cell proliferation by regulating the ERK1/2 and COX-2 pathways.	Lovastatin	21-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-106
35401918-6	2022	The new manganese-based SOD mimics display a higher intrinsic SOD activity and also improved kinetic inertness in metal ion exchange processes (with Zn(II), Cu(II), Ni(II), and Co(II)).	Manganese	8-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	177-183
35401918-6	2022	The new manganese-based SOD mimics display a higher intrinsic SOD activity and also improved kinetic inertness in metal ion exchange processes (with Zn(II), Cu(II), Ni(II), and Co(II)).	Metals	114-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	177-183
35151814-6	2022	BaP induced hypomethylation of COX-2 and MSH2 in normal PBMCs and hypermethylation of APC in HCT116 CRC cells.	Benzo(a)pyrene	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-36
35274450-5	2022	An extensive morphological and crystallographic characterization of the obtained NPs shows how a higher stability against the oxidation process in ambient condition is attained when divalent cation doping of the iron oxide lattice with Co(II)  and Ni(II)  ions is performed.	ferric oxide	212-222	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	236-242
35571660-11	2022	The principal finding of this research was that lovastatin still suppressed A549 cell growth after LPS+ATP stimulation via modulation of ERK1/2, c-JUN, COX-2, BCL-2, and BAX protein levels (P<0.05).	Lovastatin	48-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-157
35091222-0	2022	Hydrogen atom abstraction mechanism for organic compound oxidation by acetylperoxyl radical in Co(II)/peracetic acid activation system.	Peracetic Acid	102-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-101
35571660-12	2022	Conclusions: Collectively, the findings presented in this study confirmed that lovastatin can inhibit A549 cell proliferation by regulating the ERK1/2 and COX-2 pathways.	Lovastatin	79-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	155-160
35091222-4	2022	In this study, a homogeneous PAA activation system was built up using Co(II) as an activator at neutral pH to generate CH3CO3  for phenol degradation.	ch3co3	119-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-76
35091222-0	2022	Hydrogen atom abstraction mechanism for organic compound oxidation by acetylperoxyl radical in Co(II)/peracetic acid activation system.	Hydrogen	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-101
35091222-4	2022	In this study, a homogeneous PAA activation system was built up using Co(II) as an activator at neutral pH to generate CH3CO3  for phenol degradation.	Phenol	131-137	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-76
35091222-0	2022	Hydrogen atom abstraction mechanism for organic compound oxidation by acetylperoxyl radical in Co(II)/peracetic acid activation system.	acetylperoxyl radical	70-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-101
35409780-4	2022	RESULTS: MACE development was associated with the use of selective COX-2is (especially with annual cDDD > 132) and corticosteroids, residence in rural regions, and well-known associated comorbidities, but not with the use of traditional NSAIDs, preferential COX-2i, biologics, methotrexate, sulfasalazine, and common EAMs.	cddd > 132	99-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-72
35362396-3	2022	METHODS: The in-vitro enzyme inhibitory activity of saccharumoside-B on PLA2, COX-1, COX-2, and 5-LOX enzymes were evaluated by the cell-free method, its effect on TNF-alpha, IL-1beta, and IL-6 secretion levels in LPS stimulated THP-1 human monocytes was determined by ELISA based methods.	Saccharumoside B	52-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-90
35274660-2	2022	The magnetic anisotropy of sixteen seven-coordinate high-spin CoII complexes with O, N, Cl and I donors was investigated with state-of-the-art ab initio CASSCF/NEVPT2 calculations and compared with experimental data.	Nitrogen	85-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-66
35274660-2	2022	The magnetic anisotropy of sixteen seven-coordinate high-spin CoII complexes with O, N, Cl and I donors was investigated with state-of-the-art ab initio CASSCF/NEVPT2 calculations and compared with experimental data.	Iodine	95-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-66
35356289-4	2022	In the progression of hepatocellular carcinoma, PGE2 can promote the proliferation and migration of liver cancer cells by affecting hepatocytes directly and the tumor microenvironment (TME) through ERK/COX-2/PGE2 signal pathway in hepatic stellate cells (HSC).	Dinoprostone	48-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	202-207
35258057-2	2022	In compounds 1 and 2, the Co(II) atoms are connected by polycarboxylate ligands to form two-dimensional (2D) layers that are pillared by tib ligands leading to the formation of 3D porous frameworks.	polycarboxylate	56-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-32
35040550-1	2022	An asymmetric allylic C-H functionalization has been developed by making use of transient chiral nucleophiles, as well as bimetallic synergistic catalysis with an achiral Pd(0) catalyst and a chiral N,N"-dioxide-Co(II) complex.	pd(0)	171-176	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	212-218
35335756-2	2022	For this purpose, several THPP and metal complexes were synthesized with different central metal ions: Co(II), Ni(II), Cu(II), and Zn(II).	5,10,15,20-tetra(4-hydroxyphenyl)porphyrin	26-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-109
35326406-7	2022	UNC1999-induced H3K27me3 inhibition reversed the hyperinflammatory responses of dual-stressed PA cultures characterized by increased COX2 expression, PGE2 secretion and THP1 adhesion.	Palmitic Acid	94-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	133-137
35364429-7	2022	These vitamins can also modulate genes induced by DAB (IL1B, IL6, IL10, iNOS, COX2, NFkappaB, GSK3B, TNF, and APP) in SH-SY5Y cells.	3,3'-Diaminobenzidine	50-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-82
35230085-4	2022	When the complexed metal ion is Mn(II), Fe(II), Co(II), or Ni(II), both incoherent tunneling and hysteresis are observed for a voltage range between +1.0 V and -1.0 V. When the metal ion is Cr(II) or Cu(II), however, only resonant (one-step) tunneling is observed, and the junctions exhibit no hysteresis and do not enter the incoherent tunneling regime.	Metals	19-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-54
35230085-4	2022	When the complexed metal ion is Mn(II), Fe(II), Co(II), or Ni(II), both incoherent tunneling and hysteresis are observed for a voltage range between +1.0 V and -1.0 V. When the metal ion is Cr(II) or Cu(II), however, only resonant (one-step) tunneling is observed, and the junctions exhibit no hysteresis and do not enter the incoherent tunneling regime.	Metals	177-182	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-54
35230085-4	2022	When the complexed metal ion is Mn(II), Fe(II), Co(II), or Ni(II), both incoherent tunneling and hysteresis are observed for a voltage range between +1.0 V and -1.0 V. When the metal ion is Cr(II) or Cu(II), however, only resonant (one-step) tunneling is observed, and the junctions exhibit no hysteresis and do not enter the incoherent tunneling regime.	cr(ii)	190-196	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-54
35230085-4	2022	When the complexed metal ion is Mn(II), Fe(II), Co(II), or Ni(II), both incoherent tunneling and hysteresis are observed for a voltage range between +1.0 V and -1.0 V. When the metal ion is Cr(II) or Cu(II), however, only resonant (one-step) tunneling is observed, and the junctions exhibit no hysteresis and do not enter the incoherent tunneling regime.	cu(ii)	200-206	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-54
35226810-0	2022	Co(II)-Catalyzed C-H/N-H Annulation of Cyclic Alkenes with Indole-2-carboxamides at Room Temperature: One-Step Access to beta-Carboline-1-one Derivatives.	Cycloparaffins	39-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
35226810-0	2022	Co(II)-Catalyzed C-H/N-H Annulation of Cyclic Alkenes with Indole-2-carboxamides at Room Temperature: One-Step Access to beta-Carboline-1-one Derivatives.	indole-2-carboxamides	59-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
35226810-0	2022	Co(II)-Catalyzed C-H/N-H Annulation of Cyclic Alkenes with Indole-2-carboxamides at Room Temperature: One-Step Access to beta-Carboline-1-one Derivatives.	beta-carboline-1-one	121-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
35234225-0	2022	A tetra Co(II/III) complex with an open cubane Co4O4 core and square-pyramidal Co(II) and octahedral Co(III) centres: bifunctional electrocatalytic activity towards water splitting at neutral pH.	co(ii	8-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-85
35234225-0	2022	A tetra Co(II/III) complex with an open cubane Co4O4 core and square-pyramidal Co(II) and octahedral Co(III) centres: bifunctional electrocatalytic activity towards water splitting at neutral pH.	Water	165-170	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-85
35326406-0	2022	Palmitate-Triggered COX2/PGE2-Related Hyperinflammation in Dual-Stressed PdL Fibroblasts Is Mediated by Repressive H3K27 Trimethylation.	Palmitates	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-24
35326406-4	2022	Hyperinflammatory COX2/PGE2 signaling was reported for human PdL fibroblasts (HPdLFs) concomitantly stressed with Porphyromonas gingivalis lipopolysaccharides and compressive force after exposure to palmitic acid (PA).	Palmitic Acid	199-212	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-22
35326406-4	2022	Hyperinflammatory COX2/PGE2 signaling was reported for human PdL fibroblasts (HPdLFs) concomitantly stressed with Porphyromonas gingivalis lipopolysaccharides and compressive force after exposure to palmitic acid (PA).	Palmitic Acid	214-216	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-22
35326406-7	2022	UNC1999-induced H3K27me3 inhibition reversed the hyperinflammatory responses of dual-stressed PA cultures characterized by increased COX2 expression, PGE2 secretion and THP1 adhesion.	UNC1999	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	133-137
35356289-4	2022	In the progression of hepatocellular carcinoma, PGE2 can promote the proliferation and migration of liver cancer cells by affecting hepatocytes directly and the tumor microenvironment (TME) through ERK/COX-2/PGE2 signal pathway in hepatic stellate cells (HSC).	Dinoprostone	208-212	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	202-207
35356289-5	2022	For the treatment of hepatocellular carcinoma, there are drugs such as T7 peptide and EP1 antagonist ONO-8711 targeting Cox-2/PGE2 axis to inhibit tumor progression.	ONO 8711	101-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-125
35201753-7	2022	Due to the strong N coordination sites and the electronic interaction between the -NH4+ groups of Pc-POSS-POPs and AuCl4-, Pc-POSS-POPs also exhibited excellent selectivity toward gold over several coordinated metals (Cr (VI), Co (II), Cd (II), Ni (II), and Hg (II)).	Ammonium Compounds	83-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	227-234
35356289-5	2022	For the treatment of hepatocellular carcinoma, there are drugs such as T7 peptide and EP1 antagonist ONO-8711 targeting Cox-2/PGE2 axis to inhibit tumor progression.	Dinoprostone	126-130	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-125
35041773-3	2022	The electrocatalytic H 2 generating capabilities of two Co(II) complexes, (Co(kappa 3 -2,6-{Ph 2 PNR} 2 (NC 5 H 3 ))Br 2 ) R = H ( I) R = Me ( II ) are presented for a variety of proton sources including trifluoroacetic acid (TFA), acetic acid (AA) and trifluoroethanol (TFE).	Cobalt	75-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-62
35201753-7	2022	Due to the strong N coordination sites and the electronic interaction between the -NH4+ groups of Pc-POSS-POPs and AuCl4-, Pc-POSS-POPs also exhibited excellent selectivity toward gold over several coordinated metals (Cr (VI), Co (II), Cd (II), Ni (II), and Hg (II)).	aucl4	115-120	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	227-234
35201753-7	2022	Due to the strong N coordination sites and the electronic interaction between the -NH4+ groups of Pc-POSS-POPs and AuCl4-, Pc-POSS-POPs also exhibited excellent selectivity toward gold over several coordinated metals (Cr (VI), Co (II), Cd (II), Ni (II), and Hg (II)).	Chromium	218-220	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	227-234
35201753-7	2022	Due to the strong N coordination sites and the electronic interaction between the -NH4+ groups of Pc-POSS-POPs and AuCl4-, Pc-POSS-POPs also exhibited excellent selectivity toward gold over several coordinated metals (Cr (VI), Co (II), Cd (II), Ni (II), and Hg (II)).	cd (ii)	236-243	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	227-234
35201753-7	2022	Due to the strong N coordination sites and the electronic interaction between the -NH4+ groups of Pc-POSS-POPs and AuCl4-, Pc-POSS-POPs also exhibited excellent selectivity toward gold over several coordinated metals (Cr (VI), Co (II), Cd (II), Ni (II), and Hg (II)).	ni (ii)	245-252	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	227-234
35201753-7	2022	Due to the strong N coordination sites and the electronic interaction between the -NH4+ groups of Pc-POSS-POPs and AuCl4-, Pc-POSS-POPs also exhibited excellent selectivity toward gold over several coordinated metals (Cr (VI), Co (II), Cd (II), Ni (II), and Hg (II)).	hg (ii)	258-265	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	227-234
35041773-3	2022	The electrocatalytic H 2 generating capabilities of two Co(II) complexes, (Co(kappa 3 -2,6-{Ph 2 PNR} 2 (NC 5 H 3 ))Br 2 ) R = H ( I) R = Me ( II ) are presented for a variety of proton sources including trifluoroacetic acid (TFA), acetic acid (AA) and trifluoroethanol (TFE).	Trifluoroacetic Acid	204-224	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-62
35041773-3	2022	The electrocatalytic H 2 generating capabilities of two Co(II) complexes, (Co(kappa 3 -2,6-{Ph 2 PNR} 2 (NC 5 H 3 ))Br 2 ) R = H ( I) R = Me ( II ) are presented for a variety of proton sources including trifluoroacetic acid (TFA), acetic acid (AA) and trifluoroethanol (TFE).	Trifluoroacetic Acid	226-229	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-62
35041773-3	2022	The electrocatalytic H 2 generating capabilities of two Co(II) complexes, (Co(kappa 3 -2,6-{Ph 2 PNR} 2 (NC 5 H 3 ))Br 2 ) R = H ( I) R = Me ( II ) are presented for a variety of proton sources including trifluoroacetic acid (TFA), acetic acid (AA) and trifluoroethanol (TFE).	Acetic Acid	232-243	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-62
35041773-3	2022	The electrocatalytic H 2 generating capabilities of two Co(II) complexes, (Co(kappa 3 -2,6-{Ph 2 PNR} 2 (NC 5 H 3 ))Br 2 ) R = H ( I) R = Me ( II ) are presented for a variety of proton sources including trifluoroacetic acid (TFA), acetic acid (AA) and trifluoroethanol (TFE).	Trifluoroethanol	253-269	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-62
35041773-3	2022	The electrocatalytic H 2 generating capabilities of two Co(II) complexes, (Co(kappa 3 -2,6-{Ph 2 PNR} 2 (NC 5 H 3 ))Br 2 ) R = H ( I) R = Me ( II ) are presented for a variety of proton sources including trifluoroacetic acid (TFA), acetic acid (AA) and trifluoroethanol (TFE).	Trifluoroethanol	271-274	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-62
35171175-0	2022	Two Co(II)/Ni(II) complexes based on nitrogenous heterocyclic ligands as high-performance electrocatalysts for the hydrogen evolution reaction.	Nickel(2+)	11-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
35172100-0	2022	Catalytic Mechanism of Competing Proton Transfer Events from Water and Acetic Acid by (CoII(bpbH2)Cl2) for Water Splitting Processes.	Water	61-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-91
35171175-0	2022	Two Co(II)/Ni(II) complexes based on nitrogenous heterocyclic ligands as high-performance electrocatalysts for the hydrogen evolution reaction.	Hydrogen	115-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
35065465-0	2022	Design, synthesis, and pharmacological evaluation of novel and selective COX-2 inhibitors based on celecoxib scaffold supported with in vivo anti-inflammatory activity, ulcerogenic liability, ADME profiling and docking study.	Celecoxib	99-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-78
35335124-7	2022	The signals at positive electrochemical potential correspond to irreversible oxidation of the boron cage (the C2B9 building block) and at negative potential correspond to the reversible redox process of (CoIII/CoII) at the central atom.	Boron	94-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	210-214
35065465-1	2022	Four new series of 1,2,4 triazole derivatives 4a,b 5a-d, 6a-f, and 7a,b possessing methylsulphonylphenyl moiety as COX-2 pharmacophore were designed and synthesized.	1,2,4-triazole	19-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-120
35172100-0	2022	Catalytic Mechanism of Competing Proton Transfer Events from Water and Acetic Acid by (CoII(bpbH2)Cl2) for Water Splitting Processes.	Acetic Acid	71-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-91
35172100-0	2022	Catalytic Mechanism of Competing Proton Transfer Events from Water and Acetic Acid by (CoII(bpbH2)Cl2) for Water Splitting Processes.	Water	107-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-91
35172100-1	2022	We performed first principles simulations to explore the water reduction process of the cobalt complex (CoII(bpbH2)Cl2), where bpbH2 = N,N"-bis(2"-pyridine carboxamide)-1,2-benzene.	Water	57-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-108
35172100-1	2022	We performed first principles simulations to explore the water reduction process of the cobalt complex (CoII(bpbH2)Cl2), where bpbH2 = N,N"-bis(2"-pyridine carboxamide)-1,2-benzene.	Cobalt	88-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-108
35172100-1	2022	We performed first principles simulations to explore the water reduction process of the cobalt complex (CoII(bpbH2)Cl2), where bpbH2 = N,N"-bis(2"-pyridine carboxamide)-1,2-benzene.	bpbh2	127-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-108
35172100-1	2022	We performed first principles simulations to explore the water reduction process of the cobalt complex (CoII(bpbH2)Cl2), where bpbH2 = N,N"-bis(2"-pyridine carboxamide)-1,2-benzene.	n,n"-bis(2"-pyridine carboxamide)-1,2-benzene	135-180	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-108
35172100-3	2022	An experimental study of the catalyst showed that the increase in the acetic acid concentration triggers catalytic current and reduction of Co(II) to Co(I), and protonation occurred, yielding a Co(III)-H intermediate.	Acetic Acid	70-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-146
35172100-3	2022	An experimental study of the catalyst showed that the increase in the acetic acid concentration triggers catalytic current and reduction of Co(II) to Co(I), and protonation occurred, yielding a Co(III)-H intermediate.	co(iii)	194-201	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-146
35172100-8	2022	The second proton transfer from water to the CoII-H moiety requires less free energy than acetic acid and is the rate-limiting step.	Water	32-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-49
35172100-8	2022	The second proton transfer from water to the CoII-H moiety requires less free energy than acetic acid and is the rate-limiting step.	Acetic Acid	90-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-49
35234840-4	2022	HYPOTHESIS: The selective COX-2 Inhibitor celecoxib has a superior cardiorenal safety profile when compared to ibuprofen or naproxen in the PRECISION population.	Celecoxib	42-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-31
34999424-0	2022	Reaction of a {Co(NO)}8 complex with superoxide: Formation of a six coordinated (CoII(NO)(O2-)) species followed by peroxynitrite intermediate.	co(no)}	15-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-85
35042267-0	2022	Evaluation of the Genotoxic Potential of the Selective COX-2 Inhibitor Enflicoxib in a Battery of in vitro and in vivo Genotoxicity Assays.	enflicoxib	71-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-60
35092909-9	2022	RESULTS: FLA had a significant inhibitory effect on the proliferation of HFLS-RA induced by IL-1beta, which was accompanied by decreased expression levels of TNF-alpha, IL-6, MMP-1, MMP-3, COX-2 and PGE2.	fla	9-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	189-194
34999424-0	2022	Reaction of a {Co(NO)}8 complex with superoxide: Formation of a six coordinated (CoII(NO)(O2-)) species followed by peroxynitrite intermediate.	Superoxides	37-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-85
34999424-0	2022	Reaction of a {Co(NO)}8 complex with superoxide: Formation of a six coordinated (CoII(NO)(O2-)) species followed by peroxynitrite intermediate.	Peroxynitrous Acid	116-129	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-85
34999424-5	2022	Moreover, spectroscopic studies suggested the formation of a transient six-coordinated (CoII(NO)(O2-)) species.	Oxygen	97-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-92
34977995-12	2022	Further, MEAC promoted cytotoxicity against HT-29 cells by activating caspase-3 dependent apoptotic pathway with a cell cycle arrest at the G1/S phase and subsequent down regulation of COX-2 pathway.	meac	9-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	185-190
35210360-5	2022	COA7 interacts transiently with the copper metallochaperones SCO1 and SCO2 and catalyzes the reduction of disulfide bonds within these proteins, which are crucial for copper relay to COX2.	Disulfides	106-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	183-187
35007929-6	2022	Compared to the control group, the protein level of COX2 was significantly upregulated in the chlorogenic acid, CpG-DNA, and chicken IgG groups.	Chlorogenic Acid	94-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-56
35210360-5	2022	COA7 interacts transiently with the copper metallochaperones SCO1 and SCO2 and catalyzes the reduction of disulfide bonds within these proteins, which are crucial for copper relay to COX2.	Copper	167-173	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	183-187
35210360-5	2022	COA7 interacts transiently with the copper metallochaperones SCO1 and SCO2 and catalyzes the reduction of disulfide bonds within these proteins, which are crucial for copper relay to COX2.	Copper	36-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	183-187
35215035-4	2022	Therefore, Co(II) ion is six-coordinated in a distorted elongated octahedron.	octahedron	66-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-17
35228515-0	2022	miR-204-5p is sponged by TUG1 to aggravate neuron damage induced by focal cerebral ischemia and reperfusion injury through upregulating COX2.	mir-204-5p	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	136-140
35113092-6	2022	The excellent performance can be attributed to the strong interactions between the metal and support, highly dispersed cobalt nanoparticles and the Lewis acid sites induced by the coordinated unsaturated Co(II) sites in phyllosilicate.	Metals	83-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	204-210
35113092-6	2022	The excellent performance can be attributed to the strong interactions between the metal and support, highly dispersed cobalt nanoparticles and the Lewis acid sites induced by the coordinated unsaturated Co(II) sites in phyllosilicate.	Cobalt	119-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	204-210
35113092-6	2022	The excellent performance can be attributed to the strong interactions between the metal and support, highly dispersed cobalt nanoparticles and the Lewis acid sites induced by the coordinated unsaturated Co(II) sites in phyllosilicate.	Lewis Acids	148-158	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	204-210
35113092-6	2022	The excellent performance can be attributed to the strong interactions between the metal and support, highly dispersed cobalt nanoparticles and the Lewis acid sites induced by the coordinated unsaturated Co(II) sites in phyllosilicate.	phyllosilicate	220-234	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	204-210
35237322-4	2022	Methods: Meloxicam, a COX2 inhibitor with strong anti-HCC potential, was screened from 800 small molecules approved by FDA.	Meloxicam	9-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-26
35182295-1	2022	A series of 4-((4-methylphenylsulfonamido)methyl)cyclohexanecarboxylic acid (NaMSCCA) transition metal complexes (Cu(II), Zn(II), Ni(II), Mn(II), and Co(II)) have been synthesized by precipitation method.	MLS000550835	12-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	150-156
35204307-7	2022	We further found that 3,5,7-trimethoxyflavone suppressed the excessive increase in ROS, mitogen-activated protein kinases (MAPKs), Akt, and cyclooxygenase-2 (COX-2)and increased heme oxygenase (HO)-1 expression.	3,5,7-Trimethoxyflavone	22-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	158-163
35204833-7	2022	In line with the transcriptional induction of PGC1alpha, both the mRNA and protein levels of the key molecules (MTCO1, MTCO2, and COX4) related to the mitochondrial electron transport chain were increased following the butyrate treatment.	Butyrates	219-227	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-124
35183254-9	2022	Melatonin activated the protein expression of ALP, OCN, and RUNX-2 and inhibited COX-2/NF-kappaB expression.	Melatonin	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-86
35183254-12	2022	CONCLUSIONS: These results suggest that melatonin promotes the proliferation and osteogenic differentiation of DPSCs by regulating COX-2/NF-kappaB and p38/ERK MAPK signaling pathways.	Melatonin	40-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-136
35209092-1	2022	Metal-organic frameworks (M2(2-I-bdc)2bpe) (M = Zn(II) (1), Co(II) (2), 2-I-bdc = 2-iodoterephtalic acid, and bpe = 1,2-bis(4-pyridyl)ethane) were prepared and characterized by X-ray diffractometry.	Metals	0-5	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-66
35494099-1	2022	Diazomalonates have been demonstrated as effective metalloradicophiles for asymmetric radical olefin cyclopropanation via Co(II)-metalloradical catalysis (MRC).	diazomalonates	0-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-128
35494099-1	2022	Diazomalonates have been demonstrated as effective metalloradicophiles for asymmetric radical olefin cyclopropanation via Co(II)-metalloradical catalysis (MRC).	metalloradicophiles	51-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-128
35494099-1	2022	Diazomalonates have been demonstrated as effective metalloradicophiles for asymmetric radical olefin cyclopropanation via Co(II)-metalloradical catalysis (MRC).	Alkenes	94-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-128
35494099-2	2022	Supported by D 2-symmetric chiral amidoporphyrin ligand, Co(II)-based metalloradical system can efficiently activate unsymmetrical methyl phenyl diazomalonate (MPDM) with effective differentiation of the two ester groups for asymmetric cyclopropanation, enabling stereoselective construction of 1,1-cyclopropanediesters bearing two contiguous chiral centers, including all-carbon quaternary stereogenic center.	amidoporphyrin	34-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-63
35494099-2	2022	Supported by D 2-symmetric chiral amidoporphyrin ligand, Co(II)-based metalloradical system can efficiently activate unsymmetrical methyl phenyl diazomalonate (MPDM) with effective differentiation of the two ester groups for asymmetric cyclopropanation, enabling stereoselective construction of 1,1-cyclopropanediesters bearing two contiguous chiral centers, including all-carbon quaternary stereogenic center.	methyl phenyl diazomalonate	131-158	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-63
35494099-2	2022	Supported by D 2-symmetric chiral amidoporphyrin ligand, Co(II)-based metalloradical system can efficiently activate unsymmetrical methyl phenyl diazomalonate (MPDM) with effective differentiation of the two ester groups for asymmetric cyclopropanation, enabling stereoselective construction of 1,1-cyclopropanediesters bearing two contiguous chiral centers, including all-carbon quaternary stereogenic center.	mpdm	160-164	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-63
35494099-2	2022	Supported by D 2-symmetric chiral amidoporphyrin ligand, Co(II)-based metalloradical system can efficiently activate unsymmetrical methyl phenyl diazomalonate (MPDM) with effective differentiation of the two ester groups for asymmetric cyclopropanation, enabling stereoselective construction of 1,1-cyclopropanediesters bearing two contiguous chiral centers, including all-carbon quaternary stereogenic center.	Esters	208-213	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-63
35494099-2	2022	Supported by D 2-symmetric chiral amidoporphyrin ligand, Co(II)-based metalloradical system can efficiently activate unsymmetrical methyl phenyl diazomalonate (MPDM) with effective differentiation of the two ester groups for asymmetric cyclopropanation, enabling stereoselective construction of 1,1-cyclopropanediesters bearing two contiguous chiral centers, including all-carbon quaternary stereogenic center.	1,1-cyclopropanediesters	295-319	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-63
35494099-2	2022	Supported by D 2-symmetric chiral amidoporphyrin ligand, Co(II)-based metalloradical system can efficiently activate unsymmetrical methyl phenyl diazomalonate (MPDM) with effective differentiation of the two ester groups for asymmetric cyclopropanation, enabling stereoselective construction of 1,1-cyclopropanediesters bearing two contiguous chiral centers, including all-carbon quaternary stereogenic center.	Carbon	373-379	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-63
35494099-3	2022	The Co(II)-catalyzed asymmetric cyclopropanation, which operates at room temperature without slow addition of the diazo compound, is generally applicable to broad-ranging olefins and tolerates various functionalities, providing a streamlined synthesis of chiral 1,1-cyclopropanediesters in high yields with both high diastereoselectivity and enantioselectivity.	diazo compound	114-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
35494099-3	2022	The Co(II)-catalyzed asymmetric cyclopropanation, which operates at room temperature without slow addition of the diazo compound, is generally applicable to broad-ranging olefins and tolerates various functionalities, providing a streamlined synthesis of chiral 1,1-cyclopropanediesters in high yields with both high diastereoselectivity and enantioselectivity.	Alkenes	171-178	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
35494099-3	2022	The Co(II)-catalyzed asymmetric cyclopropanation, which operates at room temperature without slow addition of the diazo compound, is generally applicable to broad-ranging olefins and tolerates various functionalities, providing a streamlined synthesis of chiral 1,1-cyclopropanediesters in high yields with both high diastereoselectivity and enantioselectivity.	1,1-cyclopropanediesters	262-286	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
35424567-9	2022	Proposed radical and redox mechanisms are presented for H2O2 decomposition where the redox mechanism is suggested to predominate via a Co(ii)/Co(iii) redox consecutive cyclic process.	Hydrogen Peroxide	56-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-141
35424567-9	2022	Proposed radical and redox mechanisms are presented for H2O2 decomposition where the redox mechanism is suggested to predominate via a Co(ii)/Co(iii) redox consecutive cyclic process.	co(iii)	142-149	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-141
34990649-0	2022	Indole-linked 1,2,3-triazole derivatives efficiently modulate COX-2 protein levels in human THP-1 monocytes by suppressing AGE-ROS-NF-kbeta nexus.	indole	0-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
34990649-0	2022	Indole-linked 1,2,3-triazole derivatives efficiently modulate COX-2 protein levels in human THP-1 monocytes by suppressing AGE-ROS-NF-kbeta nexus.	Triazoles	14-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
34990649-0	2022	Indole-linked 1,2,3-triazole derivatives efficiently modulate COX-2 protein levels in human THP-1 monocytes by suppressing AGE-ROS-NF-kbeta nexus.	Reactive Oxygen Species	127-130	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
34990649-11	2022	SIGNIFICANCE: Our data revealed that the indole-triazoles 12, and 13 significantly attenuated the AGEs-induced proinflammatory COX-2 levels, and associated PGE2 production by suppressing AGE-ROS-NF-Kbeta nexus in THP-1 monocytes.	indole-triazoles	41-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	127-132
35099966-1	2022	alpha-Alkynyldiazomethanes, generated in situ from the corresponding sulfonyl hydrazones in the presence of a base, can serve as effective metalloradicophiles in Co(II)-based metalloradical catalysis (MRC) for asymmetric cyclopropanation of alkenes.	Alkenes	241-248	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	162-168
35425468-0	2022	Lanthanide induced variability in localised CoII geometries of four triangular L3Co3 IILnIII complexes.	Lanthanoid Series Elements	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-48
35425468-0	2022	Lanthanide induced variability in localised CoII geometries of four triangular L3Co3 IILnIII complexes.	l3co3 iilniii	79-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-48
35425468-3	2022	The third CoII ion assumes a different coordination geometry in each complex: six-coordinate octahedral in C1, six-coordinate with a distortion towards trigonal prismatic in C2, five-coordinate trigonal bipyramidal in C3, and five-coordinate square pyramidal in C4; which has been attributed to increasing lanthanide cation size, coupled with a non-macrocyclic coordination environment.	Lanthanoid Series Elements	306-316	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-14
35203628-3	2022	The inducible COX-2/PGE2 axis in microglia, the primary innate immune cells of the brain, is a pivotal feature in causing inflammation and neuronal injury, both in acute excitotoxic insults and chronic neurodegenerative diseases.	Dinoprostone	20-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
35203628-6	2022	Our results revealed that the levels of COX-2 mRNA and supernatant PGE2 in NG cultures, but not in microglia-enriched and MG cultures, were drastically reduced in response to the ET challenge, suggesting that the presence of neurons, rather than astroglia, is required for PGE2 tolerance in microglia.	Dinoprostone	273-277	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
35099966-1	2022	alpha-Alkynyldiazomethanes, generated in situ from the corresponding sulfonyl hydrazones in the presence of a base, can serve as effective metalloradicophiles in Co(II)-based metalloradical catalysis (MRC) for asymmetric cyclopropanation of alkenes.	alpha-alkynyldiazomethanes	0-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	162-168
35099966-1	2022	alpha-Alkynyldiazomethanes, generated in situ from the corresponding sulfonyl hydrazones in the presence of a base, can serve as effective metalloradicophiles in Co(II)-based metalloradical catalysis (MRC) for asymmetric cyclopropanation of alkenes.	sulfonyl hydrazones	69-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	162-168
35067692-4	2022	It has been shown that the biosynthesis of SPMs called eicosapentaenoic acid (EPA)-derived E-series resolvins is initiated by aspirin-acetylated COX-2 from EPA, leading to 18-hydroperoxy-eicosapentaenoic acid (18-HpEPE).	Eicosapentaenoic Acid	55-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-150
35067692-4	2022	It has been shown that the biosynthesis of SPMs called eicosapentaenoic acid (EPA)-derived E-series resolvins is initiated by aspirin-acetylated COX-2 from EPA, leading to 18-hydroperoxy-eicosapentaenoic acid (18-HpEPE).	Eicosapentaenoic Acid	78-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-150
35067692-4	2022	It has been shown that the biosynthesis of SPMs called eicosapentaenoic acid (EPA)-derived E-series resolvins is initiated by aspirin-acetylated COX-2 from EPA, leading to 18-hydroperoxy-eicosapentaenoic acid (18-HpEPE).	e-series resolvins	91-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-150
35067692-4	2022	It has been shown that the biosynthesis of SPMs called eicosapentaenoic acid (EPA)-derived E-series resolvins is initiated by aspirin-acetylated COX-2 from EPA, leading to 18-hydroperoxy-eicosapentaenoic acid (18-HpEPE).	Aspirin	126-133	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-150
35099966-2	2022	With D2-symmetric chiral amidoporphyrin 2,6-DiMeO-QingPhyrin as the optimal supporting ligand, the Co(II)-based metalloradical system can efficiently activate different alpha-alkynyldiazomethanes at room temperature for highly asymmetric cyclopropanation of a broad range of alkenes.	amidoporphyrin 2,6-dimeo-qingphyrin	25-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-105
35067692-4	2022	It has been shown that the biosynthesis of SPMs called eicosapentaenoic acid (EPA)-derived E-series resolvins is initiated by aspirin-acetylated COX-2 from EPA, leading to 18-hydroperoxy-eicosapentaenoic acid (18-HpEPE).	Eicosapentaenoic Acid	156-159	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-150
35099966-2	2022	With D2-symmetric chiral amidoporphyrin 2,6-DiMeO-QingPhyrin as the optimal supporting ligand, the Co(II)-based metalloradical system can efficiently activate different alpha-alkynyldiazomethanes at room temperature for highly asymmetric cyclopropanation of a broad range of alkenes.	alpha-alkynyldiazomethanes	169-195	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-105
35067692-4	2022	It has been shown that the biosynthesis of SPMs called eicosapentaenoic acid (EPA)-derived E-series resolvins is initiated by aspirin-acetylated COX-2 from EPA, leading to 18-hydroperoxy-eicosapentaenoic acid (18-HpEPE).	18-hydroperoxy eicosapentaenoic acid	172-208	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-150
35099966-2	2022	With D2-symmetric chiral amidoporphyrin 2,6-DiMeO-QingPhyrin as the optimal supporting ligand, the Co(II)-based metalloradical system can efficiently activate different alpha-alkynyldiazomethanes at room temperature for highly asymmetric cyclopropanation of a broad range of alkenes.	Alkenes	275-282	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-105
35067692-4	2022	It has been shown that the biosynthesis of SPMs called eicosapentaenoic acid (EPA)-derived E-series resolvins is initiated by aspirin-acetylated COX-2 from EPA, leading to 18-hydroperoxy-eicosapentaenoic acid (18-HpEPE).	18-hpepe	210-218	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-150
35208952-0	2022	EGFR and COX-2 Dual Inhibitor: The Design, Synthesis, and Biological Evaluation of Novel Chalcones.	Chalcones	89-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	9-14
35067692-6	2022	Our MD simulations, combined with QM/MM calculations, show that the potential energy barriers for the H16-abstraction from EPA, required for forming 18-HpEPE, are higher than for the H13-abstraction, thus explaining why 18-HpEPE is a marginal product of COX-2 catalysis.	Eicosapentaenoic Acid	123-126	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	254-259
35099966-4	2022	Combined computational and experimental studies offer several lines of evidence in support of the underlying stepwise radical mechanism for the Co(II)-catalyzed olefin cyclopropanation involving a unique alpha-metalloradical intermediate that is associated with two resonance forms of alpha-Co(III)-propargyl radical and gamma-Co(III)-allenyl radical.	Alkenes	161-167	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	144-150
35067692-6	2022	Our MD simulations, combined with QM/MM calculations, show that the potential energy barriers for the H16-abstraction from EPA, required for forming 18-HpEPE, are higher than for the H13-abstraction, thus explaining why 18-HpEPE is a marginal product of COX-2 catalysis.	18-hpepe	149-157	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	254-259
35099966-4	2022	Combined computational and experimental studies offer several lines of evidence in support of the underlying stepwise radical mechanism for the Co(II)-catalyzed olefin cyclopropanation involving a unique alpha-metalloradical intermediate that is associated with two resonance forms of alpha-Co(III)-propargyl radical and gamma-Co(III)-allenyl radical.	alpha-co(iii)-propargyl radical	285-316	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	144-150
35067692-6	2022	Our MD simulations, combined with QM/MM calculations, show that the potential energy barriers for the H16-abstraction from EPA, required for forming 18-HpEPE, are higher than for the H13-abstraction, thus explaining why 18-HpEPE is a marginal product of COX-2 catalysis.	18-hpepe	220-228	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	254-259
35067692-7	2022	By contrast, in the aspirin-acetylated COX-2/EPA complex, the H16proS-abstraction energy barriers are somewhat lower than the H13proS energy barriers and much smaller than the H16-transfer barriers in the wild type COX-2/EPA system.	Aspirin	20-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-44
35099966-4	2022	Combined computational and experimental studies offer several lines of evidence in support of the underlying stepwise radical mechanism for the Co(II)-catalyzed olefin cyclopropanation involving a unique alpha-metalloradical intermediate that is associated with two resonance forms of alpha-Co(III)-propargyl radical and gamma-Co(III)-allenyl radical.	gamma-co(iii)-allenyl radical	321-350	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	144-150
35067692-7	2022	By contrast, in the aspirin-acetylated COX-2/EPA complex, the H16proS-abstraction energy barriers are somewhat lower than the H13proS energy barriers and much smaller than the H16-transfer barriers in the wild type COX-2/EPA system.	Aspirin	20-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	215-220
35198762-12	2022	However, after exposure to resiquimod siRNA-mediated knockout of DUOX1/2 significantly enhanced Sp1 and IL-23 levels, and decreased TNFalpha-dependent COX-2 expression.	resiquimod	27-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-156
35067692-7	2022	By contrast, in the aspirin-acetylated COX-2/EPA complex, the H16proS-abstraction energy barriers are somewhat lower than the H13proS energy barriers and much smaller than the H16-transfer barriers in the wild type COX-2/EPA system.	Eicosapentaenoic Acid	45-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-44
35067692-7	2022	By contrast, in the aspirin-acetylated COX-2/EPA complex, the H16proS-abstraction energy barriers are somewhat lower than the H13proS energy barriers and much smaller than the H16-transfer barriers in the wild type COX-2/EPA system.	Eicosapentaenoic Acid	45-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	215-220
35067692-7	2022	By contrast, in the aspirin-acetylated COX-2/EPA complex, the H16proS-abstraction energy barriers are somewhat lower than the H13proS energy barriers and much smaller than the H16-transfer barriers in the wild type COX-2/EPA system.	h16pros	62-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-44
35067692-7	2022	By contrast, in the aspirin-acetylated COX-2/EPA complex, the H16proS-abstraction energy barriers are somewhat lower than the H13proS energy barriers and much smaller than the H16-transfer barriers in the wild type COX-2/EPA system.	h16pros	62-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	215-220
35067692-7	2022	By contrast, in the aspirin-acetylated COX-2/EPA complex, the H16proS-abstraction energy barriers are somewhat lower than the H13proS energy barriers and much smaller than the H16-transfer barriers in the wild type COX-2/EPA system.	h13pros	126-133	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-44
35067692-7	2022	By contrast, in the aspirin-acetylated COX-2/EPA complex, the H16proS-abstraction energy barriers are somewhat lower than the H13proS energy barriers and much smaller than the H16-transfer barriers in the wild type COX-2/EPA system.	Eicosapentaenoic Acid	221-224	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-44
35067692-7	2022	By contrast, in the aspirin-acetylated COX-2/EPA complex, the H16proS-abstraction energy barriers are somewhat lower than the H13proS energy barriers and much smaller than the H16-transfer barriers in the wild type COX-2/EPA system.	Eicosapentaenoic Acid	221-224	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	215-220
35067692-9	2022	In the following step of the catalytic mechanism, the calculated O2 addition to C18 is preferred versus the addition to C14 which also agrees with 18R-HEPE and 18S-HEPE being the main products from EPA in aspirin-acetylated COX-2.	18R-HEPE	147-155	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	224-229
35067692-9	2022	In the following step of the catalytic mechanism, the calculated O2 addition to C18 is preferred versus the addition to C14 which also agrees with 18R-HEPE and 18S-HEPE being the main products from EPA in aspirin-acetylated COX-2.	18S-HEPE	160-168	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	224-229
35067692-9	2022	In the following step of the catalytic mechanism, the calculated O2 addition to C18 is preferred versus the addition to C14 which also agrees with 18R-HEPE and 18S-HEPE being the main products from EPA in aspirin-acetylated COX-2.	Aspirin	205-212	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	224-229
35050271-8	2022	Catalytic studies with the cobalt(II)-acetonitrile complex ((6-Me3-TPA)CoII(CH3CN)2)(ClO4)2 (5) in the presence and absence of externally added benzoate support the role of the carboxylate co-ligand in oxidation reactions.	cobalt(ii)-acetonitrile	27-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-75
35050271-8	2022	Catalytic studies with the cobalt(II)-acetonitrile complex ((6-Me3-TPA)CoII(CH3CN)2)(ClO4)2 (5) in the presence and absence of externally added benzoate support the role of the carboxylate co-ligand in oxidation reactions.	Benzoates	144-152	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-75
35050271-8	2022	Catalytic studies with the cobalt(II)-acetonitrile complex ((6-Me3-TPA)CoII(CH3CN)2)(ClO4)2 (5) in the presence and absence of externally added benzoate support the role of the carboxylate co-ligand in oxidation reactions.	carboxylate	177-188	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-75
35371547-4	2022	The CoII cations are coordinated by four N atoms of the cyclam ligand and two trans-S atoms of the tetra-thio-anti-monate anion within slightly distorted octa-hedra.	Nitrogen	41-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-8
35159907-2	2022	We explored and compared the loading/release ability of diclofenac (COX-2 antagonist), in both undoped- and luminescent Terbium3+ (Tb3+)-doped citrate-coated carbonated apatite nanoparticles at different temperatures (25, 37, 40  C) and pHs (7.4, 5.2).	Diclofenac	56-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-73
35159907-2	2022	We explored and compared the loading/release ability of diclofenac (COX-2 antagonist), in both undoped- and luminescent Terbium3+ (Tb3+)-doped citrate-coated carbonated apatite nanoparticles at different temperatures (25, 37, 40  C) and pHs (7.4, 5.2).	terbium3+	120-129	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-73
35159907-2	2022	We explored and compared the loading/release ability of diclofenac (COX-2 antagonist), in both undoped- and luminescent Terbium3+ (Tb3+)-doped citrate-coated carbonated apatite nanoparticles at different temperatures (25, 37, 40  C) and pHs (7.4, 5.2).	tb3+	131-135	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-73
35159907-2	2022	We explored and compared the loading/release ability of diclofenac (COX-2 antagonist), in both undoped- and luminescent Terbium3+ (Tb3+)-doped citrate-coated carbonated apatite nanoparticles at different temperatures (25, 37, 40  C) and pHs (7.4, 5.2).	Citric Acid	143-150	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-73
35159907-4	2022	Biological effects of diclofenac-loaded-nanoparticles were monitored in an in vitro osteoblast"s cytokine-induced inflammation model by evaluating COX-2 mRNA expression and production of PGE2.	Diclofenac	22-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-152
35159907-10	2022	In addition, diclofenac release increased COX-2 mRNA expression and decreased PGE2 production in an in vitro inflammation model.	Diclofenac	13-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47
35136486-10	2022	Treatment with prostaglandin E2 (PGE2) induces both PACER and COX-2 expression, suggesting a PGE2-mediated feedback loop.	Dinoprostone	15-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
35136486-10	2022	Treatment with prostaglandin E2 (PGE2) induces both PACER and COX-2 expression, suggesting a PGE2-mediated feedback loop.	Dinoprostone	33-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
35136486-10	2022	Treatment with prostaglandin E2 (PGE2) induces both PACER and COX-2 expression, suggesting a PGE2-mediated feedback loop.	Dinoprostone	93-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
35136486-11	2022	Inhibition of COX-2 with celecoxib decreased PACER expression, confirming this self-regulatory process.	Celecoxib	25-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
35371547-4	2022	The CoII cations are coordinated by four N atoms of the cyclam ligand and two trans-S atoms of the tetra-thio-anti-monate anion within slightly distorted octa-hedra.	cyclam	56-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-8
35371547-4	2022	The CoII cations are coordinated by four N atoms of the cyclam ligand and two trans-S atoms of the tetra-thio-anti-monate anion within slightly distorted octa-hedra.	octa-hedra	154-164	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-8
35371547-5	2022	The unique (SbS4)3- anion is coordinated to all three crystallographically independent CoII cations and this unit, with its symmetry-related counterparts, forms rings composed of six Co-cyclam cations and six tetra-thio-anti-monate anions that are further condensed into layers.	3- anion	17-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-91
35371547-5	2022	The unique (SbS4)3- anion is coordinated to all three crystallographically independent CoII cations and this unit, with its symmetry-related counterparts, forms rings composed of six Co-cyclam cations and six tetra-thio-anti-monate anions that are further condensed into layers.	co-cyclam	183-192	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-91
35105633-4	2022	The primary objective of this study is to determine the efficacy of the COX-2-selective inhibitor celecoxib as an adjunct to treatment-as-usual in children and youth with moderate-to-severe OCD.	Celecoxib	98-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
35068152-3	2022	In this work, we study the experimentally synthesized Co(II) dimer (Co2(C5NH5)4(mu-PO2(CH2C6H5)2)3) SMM with the goal to control the exchange energy, DeltaEJ, between the Co atoms through tuning of the capping ligands.	co2(c5nh5)	68-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-60
35068152-3	2022	In this work, we study the experimentally synthesized Co(II) dimer (Co2(C5NH5)4(mu-PO2(CH2C6H5)2)3) SMM with the goal to control the exchange energy, DeltaEJ, between the Co atoms through tuning of the capping ligands.	(mu-po2(ch2c6h5)2)	79-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-60
35068152-3	2022	In this work, we study the experimentally synthesized Co(II) dimer (Co2(C5NH5)4(mu-PO2(CH2C6H5)2)3) SMM with the goal to control the exchange energy, DeltaEJ, between the Co atoms through tuning of the capping ligands.	Cobalt	171-173	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-60
35204177-9	2022	In addition, GBH restored the expression of ferroptosis marker proteins, such as GPX4, HO-1 and COX-2, which were altered by RSL3.	gbh	13-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-101
35146873-0	2022	COX-2-Hemmer: Keine praventive Wirkung gegen Hautkrebs.	keine	14-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
35049285-0	2022	Facile Transformations of a Binuclear Cp*Co(II) Diamidonaphthalene Complex to Mixed-Valent Co(II)Co(III), Co(III)(mu-H)Co(III), and Co(III)(mu-OH)Co(III) Derivatives.	co(iii)	97-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-47
35049285-0	2022	Facile Transformations of a Binuclear Cp*Co(II) Diamidonaphthalene Complex to Mixed-Valent Co(II)Co(III), Co(III)(mu-H)Co(III), and Co(III)(mu-OH)Co(III) Derivatives.	co(iii)	119-126	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-47
35049285-0	2022	Facile Transformations of a Binuclear Cp*Co(II) Diamidonaphthalene Complex to Mixed-Valent Co(II)Co(III), Co(III)(mu-H)Co(III), and Co(III)(mu-OH)Co(III) Derivatives.	co(iii)	146-153	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-47
35013253-3	2022	The results show that if emissions peak in 2025, the carbon neutrality goal calls for a 45-62% electrification rate, 47-78% renewable energy in primary energy supply, 5.2-7.9 TW of solar and wind power, 1.5-2.7 PWh of energy storage usage and 64-1,649 MtCO2 of negative emissions, and synergistically reducing approximately 80% of local air pollutants compared to the present level in 2050.	Carbon	53-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	252-257
35049285-2	2022	It was found that the Co(II)-Co(II) bond allows for protonation by (HPPh3)(BF4) resulting in a bridging hydride, (1H)+, with pKa ~ 7.6 in CH2Cl2.	Hydrogen	114-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-28
35049285-2	2022	It was found that the Co(II)-Co(II) bond allows for protonation by (HPPh3)(BF4) resulting in a bridging hydride, (1H)+, with pKa ~ 7.6 in CH2Cl2.	Hydrogen	114-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-35
35049285-2	2022	It was found that the Co(II)-Co(II) bond allows for protonation by (HPPh3)(BF4) resulting in a bridging hydride, (1H)+, with pKa ~ 7.6 in CH2Cl2.	Methylene Chloride	138-144	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-28
35049285-2	2022	It was found that the Co(II)-Co(II) bond allows for protonation by (HPPh3)(BF4) resulting in a bridging hydride, (1H)+, with pKa ~ 7.6 in CH2Cl2.	Methylene Chloride	138-144	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-35
35164168-3	2022	Herein, a biomimetic catalytic system composed of metallophthalocyanines (MPcR4, M = Mn(II), Fe(II), Co(II), Ni(II), Cu(II), Zn(II); R = -H, -COOH, -NO2, -NH2) and molecular O2 was performed to study the influence of MN4-type coordination structure in metallophthalocyanines for the degradation of dibenzothiophene (DBT) in model oil containing n-octane.	metallophthalocyanines	50-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-107
35164168-3	2022	Herein, a biomimetic catalytic system composed of metallophthalocyanines (MPcR4, M = Mn(II), Fe(II), Co(II), Ni(II), Cu(II), Zn(II); R = -H, -COOH, -NO2, -NH2) and molecular O2 was performed to study the influence of MN4-type coordination structure in metallophthalocyanines for the degradation of dibenzothiophene (DBT) in model oil containing n-octane.	mpcr4	74-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-107
34988578-1	2022	In the present report, three mononuclear azo-aromatic complexes of Co(II), 1-3, and an imine-based Co(II) complex, 4, were synthesized through a reaction of respective amine-functionalized pincer-like ligands, HL1-4, with CoCl2 6H2O in the ligand-to-metal ratio of 1 : 1.	Imines	87-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-105
34988578-1	2022	In the present report, three mononuclear azo-aromatic complexes of Co(II), 1-3, and an imine-based Co(II) complex, 4, were synthesized through a reaction of respective amine-functionalized pincer-like ligands, HL1-4, with CoCl2 6H2O in the ligand-to-metal ratio of 1 : 1.	Amines	168-173	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-105
34988578-1	2022	In the present report, three mononuclear azo-aromatic complexes of Co(II), 1-3, and an imine-based Co(II) complex, 4, were synthesized through a reaction of respective amine-functionalized pincer-like ligands, HL1-4, with CoCl2 6H2O in the ligand-to-metal ratio of 1 : 1.	cocl2 6h2o	222-232	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-105
34988578-1	2022	In the present report, three mononuclear azo-aromatic complexes of Co(II), 1-3, and an imine-based Co(II) complex, 4, were synthesized through a reaction of respective amine-functionalized pincer-like ligands, HL1-4, with CoCl2 6H2O in the ligand-to-metal ratio of 1 : 1.	Metals	250-255	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-105
34991150-4	2022	The Co(II) complex with 3,9-PC2AMtBu shows a similar six-coordinate structure in the solid state, while the Co(II) complex with 3,9-PC2AMH contains a seven-coordinate metal ion, seventh coordination being completed by the presence of an inner-sphere water molecule.	3,9-pc2amtbu	24-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
34991150-4	2022	The Co(II) complex with 3,9-PC2AMtBu shows a similar six-coordinate structure in the solid state, while the Co(II) complex with 3,9-PC2AMH contains a seven-coordinate metal ion, seventh coordination being completed by the presence of an inner-sphere water molecule.	3,9-pc2amh	128-138	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-114
34991150-4	2022	The Co(II) complex with 3,9-PC2AMtBu shows a similar six-coordinate structure in the solid state, while the Co(II) complex with 3,9-PC2AMH contains a seven-coordinate metal ion, seventh coordination being completed by the presence of an inner-sphere water molecule.	Metals	167-172	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-114
34991150-4	2022	The Co(II) complex with 3,9-PC2AMtBu shows a similar six-coordinate structure in the solid state, while the Co(II) complex with 3,9-PC2AMH contains a seven-coordinate metal ion, seventh coordination being completed by the presence of an inner-sphere water molecule.	Water	250-255	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
34991150-4	2022	The Co(II) complex with 3,9-PC2AMtBu shows a similar six-coordinate structure in the solid state, while the Co(II) complex with 3,9-PC2AMH contains a seven-coordinate metal ion, seventh coordination being completed by the presence of an inner-sphere water molecule.	Water	250-255	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-114
34991150-5	2022	The structure of the Co(II) complexes was investigated using 1H NMR spectroscopy and computational methods.	Hydrogen	61-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-27
34991150-8	2022	The Co(II) complex was found to be more stable than the Ni(II) analogue (log KCoL = 14.46(5) and log KNiL = 13.15(3)).	kcol	77-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
34991150-8	2022	The Co(II) complex was found to be more stable than the Ni(II) analogue (log KCoL = 14.46(5) and log KNiL = 13.15(3)).	knil	101-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
34991150-10	2022	The presence of highly shifted 1H NMR signals due to the amide protons in slow exchange with bulk water results in sizeable CEST signals, which are observed at +67 and +15 ppm for the Co(II) complex with 3,9-PC2AMH and +42 and +7 ppm for the Ni(II) analogue at 25  C.	Hydrogen	31-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	184-190
34991150-10	2022	The presence of highly shifted 1H NMR signals due to the amide protons in slow exchange with bulk water results in sizeable CEST signals, which are observed at +67 and +15 ppm for the Co(II) complex with 3,9-PC2AMH and +42 and +7 ppm for the Ni(II) analogue at 25  C.	Amides	57-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	184-190
34991150-10	2022	The presence of highly shifted 1H NMR signals due to the amide protons in slow exchange with bulk water results in sizeable CEST signals, which are observed at +67 and +15 ppm for the Co(II) complex with 3,9-PC2AMH and +42 and +7 ppm for the Ni(II) analogue at 25  C.	Water	98-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	184-190
34991150-10	2022	The presence of highly shifted 1H NMR signals due to the amide protons in slow exchange with bulk water results in sizeable CEST signals, which are observed at +67 and +15 ppm for the Co(II) complex with 3,9-PC2AMH and +42 and +7 ppm for the Ni(II) analogue at 25  C.	3,9-pc2amh	204-214	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	184-190
34991150-10	2022	The presence of highly shifted 1H NMR signals due to the amide protons in slow exchange with bulk water results in sizeable CEST signals, which are observed at +67 and +15 ppm for the Co(II) complex with 3,9-PC2AMH and +42 and +7 ppm for the Ni(II) analogue at 25  C.	Nickel(2+)	242-248	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	184-190
34982530-3	2022	Here, the response of the composition, structure, and electrochemical performance of EABs to the selective adhesion pressure due to the selective coordination of Fe(III) and Co(II) with thiol and the different affinities for bacteria on hybrid electrodes (Fe1Co, Fe4Co, and Fe10Co) were comprehensively investigated.	eabs	85-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	174-180
34982530-3	2022	Here, the response of the composition, structure, and electrochemical performance of EABs to the selective adhesion pressure due to the selective coordination of Fe(III) and Co(II) with thiol and the different affinities for bacteria on hybrid electrodes (Fe1Co, Fe4Co, and Fe10Co) were comprehensively investigated.	Sulfhydryl Compounds	186-191	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	174-180
34985240-3	2022	Among the nine combinations of transition metals and peroxides used in this study, the combination of Co(II) and peroxymonosulfate (PMS) peroxide was the most effective for surface modification of HDPE, followed closely by the combination of Ru(III) and PMS.	Peroxides	53-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-108
34985240-3	2022	Among the nine combinations of transition metals and peroxides used in this study, the combination of Co(II) and peroxymonosulfate (PMS) peroxide was the most effective for surface modification of HDPE, followed closely by the combination of Ru(III) and PMS.	pms) peroxide	132-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-108
34985240-3	2022	Among the nine combinations of transition metals and peroxides used in this study, the combination of Co(II) and peroxymonosulfate (PMS) peroxide was the most effective for surface modification of HDPE, followed closely by the combination of Ru(III) and PMS.	peroxymonosulfate	254-257	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-108
34985240-7	2022	After only 20 min of surface treatment with Co(II)/PMS solution, the adhesion strength at the interface of HDPE and the epoxy coating increased by 193%, confirming the importance of polyolefins" surface functionality on their interfacial adhesion properties.	PL 732	182-193	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-50
35053273-2	2022	Copper is bound to COX1 and COX2, two core subunits of CcO, forming the CuB and CuA sites, respectively.	Copper	0-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-32
35053273-6	2022	Initial genetic and biochemical studies have linked COA6 with copper delivery to COX2 and follow-up structural and functional studies have shown that it is specifically required for the biogenesis of the CuA site by acting as a disulfide reductase of SCO and COX2 proteins.	Copper	62-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-85
35056753-0	2022	Anti-Phototoxicity Effect of Phenolic Compounds from Acetone Extract of Entada phaseoloides Leaves via Activation of COX-2 and iNOS in Human Epidermal Keratinocytes.	Acetone	53-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-122
35056753-4	2022	Protocatechuic acid (2), epicatechin (4), and kaempferol (11) at a concentration 100 muM increased the HaCaT cells viability of the UVB-irradiated cell without any cytotoxicity effect and reduced the expression of COX-2 and iNOS inflammation gene.	protocatechuic acid	0-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	214-219
35056753-4	2022	Protocatechuic acid (2), epicatechin (4), and kaempferol (11) at a concentration 100 muM increased the HaCaT cells viability of the UVB-irradiated cell without any cytotoxicity effect and reduced the expression of COX-2 and iNOS inflammation gene.	Catechin	25-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	214-219
35056753-4	2022	Protocatechuic acid (2), epicatechin (4), and kaempferol (11) at a concentration 100 muM increased the HaCaT cells viability of the UVB-irradiated cell without any cytotoxicity effect and reduced the expression of COX-2 and iNOS inflammation gene.	kaempferol	46-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	214-219
34988578-0	2022	Polymerisation of styrene using pincer type amine functionalized azo aromatic complexes of Co(II) as catalysts.	Styrene	18-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-97
34988578-0	2022	Polymerisation of styrene using pincer type amine functionalized azo aromatic complexes of Co(II) as catalysts.	Amines	44-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-97
34988578-0	2022	Polymerisation of styrene using pincer type amine functionalized azo aromatic complexes of Co(II) as catalysts.	azo aromatic	65-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-97
35204104-6	2022	In addition, HC-EA, quercitrin, and hyperoside attenuated UVB-induced inflammatory mediators, including IL-6, IL-8, COX-2, and iNOS.	hc-ea	13-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-121
35204104-6	2022	In addition, HC-EA, quercitrin, and hyperoside attenuated UVB-induced inflammatory mediators, including IL-6, IL-8, COX-2, and iNOS.	quercitrin	20-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-121
35111001-4	2021	In addition, elamipretide has been shown to attenuate neural oxidative stress (hydrogen peroxide, lipid peroxidation, and ROS), neuroinflammation (TNF, IL-6, COX-2, iNOS, NLRP3, cleaved caspase-1, IL-1beta, and IL-18), and toxic protein accumulation (Abeta).	arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide	13-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	158-163
35377978-14	2022	MiR-30a-3p played an opposite role and inhibited the effects of FOXD2-AS1 and COX-2 overexpression.	mir-30a-3p	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-83
34877950-1	2022	Divalent transition metals such as Co(II) are important targets for removal from water sources, due to their potential toxicity as well as their high value.	Water	81-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-41
34877950-2	2022	In this study, we found that a series of porous organic polymers based on amide-linked tetraphenylmethane units are effective Co(II) ion adsorbents in aqueous solution.	Polymers	56-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-132
34877950-2	2022	In this study, we found that a series of porous organic polymers based on amide-linked tetraphenylmethane units are effective Co(II) ion adsorbents in aqueous solution.	amide-linked tetraphenylmethane	74-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-132
34983353-2	2022	By affecting the cyclooxygenase 1 and 2 (COX-1 and COX-2) enzymes and actin filaments, acetylsalicylic acid (Aspirin) has been shown to reduce the risk of breast cancer and prevent cell migration in both laboratory and clinical studies.	Aspirin	87-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-56
34983353-2	2022	By affecting the cyclooxygenase 1 and 2 (COX-1 and COX-2) enzymes and actin filaments, acetylsalicylic acid (Aspirin) has been shown to reduce the risk of breast cancer and prevent cell migration in both laboratory and clinical studies.	Aspirin	109-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-56
35079428-2	2022	Its crystal structure consists of discrete complexes that are located on twofold rotation axes, in which the CoII cations are tetra-hedrally coordinated by two terminal N-bonded thio-cyanate anions and two 1,3-di-cyclo-hexyl-thio-urea ligands.	n-bonded thio-cyanate	169-190	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-113
35079428-2	2022	Its crystal structure consists of discrete complexes that are located on twofold rotation axes, in which the CoII cations are tetra-hedrally coordinated by two terminal N-bonded thio-cyanate anions and two 1,3-di-cyclo-hexyl-thio-urea ligands.	Urea	230-234	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-113
35008977-7	2022	Schiff base 13, containing 2-bromobenzylidene residue inhibited the activity of both isoenzymes, COX-1 and COX-2 at a lower concentration than standard drugs, and its COX-2/COX-1 selectivity ratio was similar to meloxicam.	Schiff Bases	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-112
35008977-7	2022	Schiff base 13, containing 2-bromobenzylidene residue inhibited the activity of both isoenzymes, COX-1 and COX-2 at a lower concentration than standard drugs, and its COX-2/COX-1 selectivity ratio was similar to meloxicam.	Schiff Bases	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	167-172
35008977-7	2022	Schiff base 13, containing 2-bromobenzylidene residue inhibited the activity of both isoenzymes, COX-1 and COX-2 at a lower concentration than standard drugs, and its COX-2/COX-1 selectivity ratio was similar to meloxicam.	2-bromobenzylidene	27-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-112
35008977-7	2022	Schiff base 13, containing 2-bromobenzylidene residue inhibited the activity of both isoenzymes, COX-1 and COX-2 at a lower concentration than standard drugs, and its COX-2/COX-1 selectivity ratio was similar to meloxicam.	2-bromobenzylidene	27-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	167-172
35008977-7	2022	Schiff base 13, containing 2-bromobenzylidene residue inhibited the activity of both isoenzymes, COX-1 and COX-2 at a lower concentration than standard drugs, and its COX-2/COX-1 selectivity ratio was similar to meloxicam.	Meloxicam	212-221	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-112
35008977-7	2022	Schiff base 13, containing 2-bromobenzylidene residue inhibited the activity of both isoenzymes, COX-1 and COX-2 at a lower concentration than standard drugs, and its COX-2/COX-1 selectivity ratio was similar to meloxicam.	Meloxicam	212-221	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	167-172
35070636-0	2022	Synthesis, Spectroscopic and Biological Investigation of a New Ca(II) Complex of Meloxicam as Potential COX-2 Inhibitor.	Meloxicam	81-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
35193460-0	2022	Microwave-assisted synthesis of Co(II), Ni(II), Ti(III), and Ti (IV) complexes of iminochromeno-pyrido-pyrimidine and in vitro antiproliferative effect against H460, MCF-7, and HCT116.	iminochromeno-pyrido-pyrimidine	82-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-38
35589203-5	2022	ACATs adenosylate Cbas in two steps: (I) they generate a planar, Co(II) four-coordinate Cba to facilitate the reduction of Co(II) to Co(I), and (II) they transfer the adenosyl group from ATP to the Co(I) ion.	Adenosine Triphosphate	187-190	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-71
35589203-5	2022	ACATs adenosylate Cbas in two steps: (I) they generate a planar, Co(II) four-coordinate Cba to facilitate the reduction of Co(II) to Co(I), and (II) they transfer the adenosyl group from ATP to the Co(I) ion.	Adenosine Triphosphate	187-190	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-129
35589203-6	2022	To synthesize adenosylated corrinoids in vitro, it is imperative that anoxic conditions are maintained to avoid oxidation of Co(II) or Co(I) ions.	Corrinoids	27-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-131
35337616-4	2022	For these biosynthetic pathways, selectivity for Co(II) over other divalent metal ions with similar ionic radii and coordination chemistry remains an open question with three competing hypotheses proposed: metal affinity, tetrapyrrole distortion, and product inhibition.	Metals	76-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-55
35337616-4	2022	For these biosynthetic pathways, selectivity for Co(II) over other divalent metal ions with similar ionic radii and coordination chemistry remains an open question with three competing hypotheses proposed: metal affinity, tetrapyrrole distortion, and product inhibition.	Metals	206-211	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-55
35173933-0	2022	Kinetic trapping of a cobalt(ii) metallocage using a carbazole-containing expanded carbaporphyrinoid ligand.	carbazole	53-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-31
35173933-0	2022	Kinetic trapping of a cobalt(ii) metallocage using a carbazole-containing expanded carbaporphyrinoid ligand.	carbaporphyrinoid	83-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-31
35173933-1	2022	The meso-unsubstituted expanded porphyrinoid 3, incorporating two carbazole moieties, acts as an effective ligand for Co(ii) and permits the isolation and X-ray diffraction-based characterization of a 6 : 3 metal-to-ligand metallocage complex that converts spontaneously to the constituent 2 : 1 metal-to-ligand metalloring species in chloroform solution.	porphyrinoid	32-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-124
35173933-1	2022	The meso-unsubstituted expanded porphyrinoid 3, incorporating two carbazole moieties, acts as an effective ligand for Co(ii) and permits the isolation and X-ray diffraction-based characterization of a 6 : 3 metal-to-ligand metallocage complex that converts spontaneously to the constituent 2 : 1 metal-to-ligand metalloring species in chloroform solution.	carbazole	66-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-124
18964222-3	1986	The relative orders of the Langmuir constants K and the column retention-capacity factors k" for the four transition-metal ions are the same as the natural order of the stabilities predicted for their metal chelates: Fe(II) &lt; Co(II) &lt; Ni(II) &lt; Cu(II).	Metals	117-122	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	229-235
2554814-1	1989	We have employed the electron spin resonance spin-trapping technique to study the reaction of Co(II) with hydrogen peroxide in a chemical system and in a microsomal system.	Hydrogen Peroxide	106-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-100
2554814-8	1989	In addition, Fe(II)-mediated DMPO/.OH formation increased when the iron was chelated to either EDTA or DTPA rather than being inhibited as for Co(II).	ammonium ferrous sulfate	13-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	143-149
2554814-8	1989	In addition, Fe(II)-mediated DMPO/.OH formation increased when the iron was chelated to either EDTA or DTPA rather than being inhibited as for Co(II).	Iron	67-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	143-149
2554814-9	1989	Thus, we propose that Co(II) does not react with hydrogen peroxide by the classical Fenton reaction at physiological pH values.	Hydrogen Peroxide	49-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-28
2562423-1	1989	The effect of Co(II) ion on the reaction of hydrogen peroxide with DNA was investigated by a DNA sequencing technique using 32P-5"-end-labeled DNA fragments obtained from human c-Ha-ras-1 protooncogene.	Hydrogen Peroxide	44-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-20
2562423-2	1989	Co(II) induced strong DNA cleavage in the presence of hydrogen peroxide even without alkali treatment.	Hydrogen Peroxide	54-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
2562423-5	1989	Diethylenetriaminepentaacetic acid, present in excess over Co(II), inhibited DNA cleavage.	Pentetic Acid	0-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
2562423-8	1989	ESR studies using 2,2,6,6-tetramethyl-4-piperidone as a singlet oxygen trap suggest that Co(II) reacts with hydrogen peroxide to produce singlet oxygen or its equivalent.	tempidon	18-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-95
2562423-8	1989	ESR studies using 2,2,6,6-tetramethyl-4-piperidone as a singlet oxygen trap suggest that Co(II) reacts with hydrogen peroxide to produce singlet oxygen or its equivalent.	Singlet Oxygen	56-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-95
2562423-8	1989	ESR studies using 2,2,6,6-tetramethyl-4-piperidone as a singlet oxygen trap suggest that Co(II) reacts with hydrogen peroxide to produce singlet oxygen or its equivalent.	Hydrogen Peroxide	108-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-95
2562423-8	1989	ESR studies using 2,2,6,6-tetramethyl-4-piperidone as a singlet oxygen trap suggest that Co(II) reacts with hydrogen peroxide to produce singlet oxygen or its equivalent.	Singlet Oxygen	137-151	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-95
2562423-10	1989	The results suggest that Co(II) ion binds to DNA and subsequently reacts with hydrogen peroxide to produce singlet oxygen and hydroxyl radicals and that singlet oxygen plays a more important role in the DNA damage than hydroxyl free radicals.	Hydrogen Peroxide	78-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-31
2562423-10	1989	The results suggest that Co(II) ion binds to DNA and subsequently reacts with hydrogen peroxide to produce singlet oxygen and hydroxyl radicals and that singlet oxygen plays a more important role in the DNA damage than hydroxyl free radicals.	singlet oxygen and hydroxyl radicals	107-143	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-31
2562423-10	1989	The results suggest that Co(II) ion binds to DNA and subsequently reacts with hydrogen peroxide to produce singlet oxygen and hydroxyl radicals and that singlet oxygen plays a more important role in the DNA damage than hydroxyl free radicals.	Singlet Oxygen	107-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-31
2509298-7	1989	Cu(I), Cu(II), and Co(II) caused a time-dependent formation of both products, with FdU predominating.	5-formyl-2'-deoxyuridine	83-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-25
18964582-2	1988	Trace amounts of Co(II) catalysed this chemiluminescent reaction strongly, especially in the presence of the cationic surfactant cetyltrimethylammonium bromide.	Cetrimonium	129-159	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-23
2840023-0	1988	Electron paramagnetic resonance study on crosslinked asymmetric Fe(II)-Co(II) hybrids of hemoglobin.	ammonium ferrous sulfate	64-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-77
2840023-4	1988	The electronic state of the Co(II) ion provides a useful probe to estimate how ligation to iron-containing subunits changes the structure of the cobalt-substituted heme vicinity as described previously (T. Inubushi and T. Yonetani (1983) Biochemistry 22, 1894-1900).	Iron	91-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-34
2840023-4	1988	The electronic state of the Co(II) ion provides a useful probe to estimate how ligation to iron-containing subunits changes the structure of the cobalt-substituted heme vicinity as described previously (T. Inubushi and T. Yonetani (1983) Biochemistry 22, 1894-1900).	Cobalt	145-151	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-34
2840023-4	1988	The electronic state of the Co(II) ion provides a useful probe to estimate how ligation to iron-containing subunits changes the structure of the cobalt-substituted heme vicinity as described previously (T. Inubushi and T. Yonetani (1983) Biochemistry 22, 1894-1900).	Heme	164-168	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-34
3411318-2	1988	This effect was detected on the enzyme having Co(II) substituted for the native Zn(II), in which the resonances of residues bound to the copper are detected because of the antiferromagnetic coupling between Cu(II) and Co(II).	Zinc	80-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-52
3411318-2	1988	This effect was detected on the enzyme having Co(II) substituted for the native Zn(II), in which the resonances of residues bound to the copper are detected because of the antiferromagnetic coupling between Cu(II) and Co(II).	Zinc	80-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	218-224
3411318-2	1988	This effect was detected on the enzyme having Co(II) substituted for the native Zn(II), in which the resonances of residues bound to the copper are detected because of the antiferromagnetic coupling between Cu(II) and Co(II).	Copper	137-143	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-52
3411318-2	1988	This effect was detected on the enzyme having Co(II) substituted for the native Zn(II), in which the resonances of residues bound to the copper are detected because of the antiferromagnetic coupling between Cu(II) and Co(II).	Copper	137-143	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	218-224
3411318-2	1988	This effect was detected on the enzyme having Co(II) substituted for the native Zn(II), in which the resonances of residues bound to the copper are detected because of the antiferromagnetic coupling between Cu(II) and Co(II).	cu(ii)	207-213	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-52
3411318-2	1988	This effect was detected on the enzyme having Co(II) substituted for the native Zn(II), in which the resonances of residues bound to the copper are detected because of the antiferromagnetic coupling between Cu(II) and Co(II).	cu(ii)	207-213	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	218-224
2827762-5	1987	Study of 6-coordinate O2-CoII(TPP)(L) complexes (L = nitrogenous base) using 14N- and 15N-labeled ligands and porphyrins enabled a detailed analysis of coupling parameters for both pyrrole and axial nitrogens.	4-(4-methylpiperazin-1-yl)benzoic acid	77-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-29
2827762-5	1987	Study of 6-coordinate O2-CoII(TPP)(L) complexes (L = nitrogenous base) using 14N- and 15N-labeled ligands and porphyrins enabled a detailed analysis of coupling parameters for both pyrrole and axial nitrogens.	15n	86-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-29
2827762-5	1987	Study of 6-coordinate O2-CoII(TPP)(L) complexes (L = nitrogenous base) using 14N- and 15N-labeled ligands and porphyrins enabled a detailed analysis of coupling parameters for both pyrrole and axial nitrogens.	Pyrroles	181-188	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-29
2827762-5	1987	Study of 6-coordinate O2-CoII(TPP)(L) complexes (L = nitrogenous base) using 14N- and 15N-labeled ligands and porphyrins enabled a detailed analysis of coupling parameters for both pyrrole and axial nitrogens.	Nitrogen	199-208	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-29
2827762-7	1987	The Fermi contact couplings for axially bound nitrogen, calculated from simulation of ESEEM spectra for a series of O2-CoII(TPP)(L) complexes (L = pyridine, 4-picoline, 4-cyanopyridine, 4-carboxypyridine, and 1-, 2-, and 4-methylimidazole) illustrate a trend toward stronger hyperfine interactions with weaker bases.	tetraphenylporphine sulfonate	124-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-123
3118948-3	1987	We report a study of the reversible amide inhibition of Co(II)-substituted CA by iodoacetamide and ethyl carbamate (urethane), as well as the ambivalent oxamate, the monoamide of oxalate.	Amides	36-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-61
3118948-3	1987	We report a study of the reversible amide inhibition of Co(II)-substituted CA by iodoacetamide and ethyl carbamate (urethane), as well as the ambivalent oxamate, the monoamide of oxalate.	Iodoacetamide	81-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-61
3118948-3	1987	We report a study of the reversible amide inhibition of Co(II)-substituted CA by iodoacetamide and ethyl carbamate (urethane), as well as the ambivalent oxamate, the monoamide of oxalate.	Urethane	99-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-61
3118948-3	1987	We report a study of the reversible amide inhibition of Co(II)-substituted CA by iodoacetamide and ethyl carbamate (urethane), as well as the ambivalent oxamate, the monoamide of oxalate.	Urethane	116-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-61
3118948-10	1987	The visible spectrum of the complex of Co(II)CA I with oxamate shows a parallel dependence on pH, reflecting this dual coordination mode.	Oxamic Acid	55-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-44
3596898-1	1987	studies of the Co (II) interaction with cyclo(Ala*-Ala) in aqueous solution.	emodepside	40-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-21
3596898-1	1987	studies of the Co (II) interaction with cyclo(Ala*-Ala) in aqueous solution.	alanylalanine	46-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-21
2613443-3	1989	Cd(II) and Co(II) also behave as Zn(II).	Zinc	33-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-17
2554966-1	1989	1H nuclear magnetic resonance (1H NMR) experiments on Co(II)-substituted stellacyanin have been performed.	Hydrogen	0-2	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-59
2554966-1	1989	1H nuclear magnetic resonance (1H NMR) experiments on Co(II)-substituted stellacyanin have been performed.	Hydrogen	31-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-59
2554966-8	1989	With apostellacyanin, tau r was found to be (6.0 +/- 0.4) X 10-8 s. From the paramagnetic susceptibility of Co(II) stellacyanin, the value (4.53 +/- 0.03)beta was determined for mu eff.	apostellacyanin	5-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-113
2546602-1	1989	Brain pyridoxal kinase, which uses ATP complexed to either Zn(II) or Co(II) as substrates, displays high catalytic activity in the presence of Zn-thionein and Co-thionein.	Adenosine Triphosphate	35-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-75
2546602-1	1989	Brain pyridoxal kinase, which uses ATP complexed to either Zn(II) or Co(II) as substrates, displays high catalytic activity in the presence of Zn-thionein and Co-thionein.	zn-thionein	143-154	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-75
2546602-1	1989	Brain pyridoxal kinase, which uses ATP complexed to either Zn(II) or Co(II) as substrates, displays high catalytic activity in the presence of Zn-thionein and Co-thionein.	co-thionein	159-170	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-75
2484613-5	1989	Cu(I), Cu(II), Co(II), and Ni(II) induced a predominant generation of FdU, with copper ions being more effective than Co and Ni.	Copper	80-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-20
18964727-0	1989	Ion-pair extraction of Co(II) by crown ethers from perchlorate medium.	Crown Ethers	33-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-28
18964727-0	1989	Ion-pair extraction of Co(II) by crown ethers from perchlorate medium.	perchlorate	51-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-28
18964727-2	1989	Slope analysis of the experimental data suggested that the extraction of Co(II) by these CEs takes place through ion-pair formation, and that the chemical formula of the main extracted species is Co(OH)(+)ClO(-)(4).CE.	co(oh)(+)clo(-)	196-211	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-78
2484421-1	1989	Schiff bases derived from salicylaldehyde and 2-substituted aniline and their metal chelates with Cu(II), Ni(II), and Co(II) ions were synthesized and screened for the antiinflammatory and antiulcer activity.	Schiff Bases	0-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-124
2484421-1	1989	Schiff bases derived from salicylaldehyde and 2-substituted aniline and their metal chelates with Cu(II), Ni(II), and Co(II) ions were synthesized and screened for the antiinflammatory and antiulcer activity.	salicylaldehyde	26-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-124
2484421-1	1989	Schiff bases derived from salicylaldehyde and 2-substituted aniline and their metal chelates with Cu(II), Ni(II), and Co(II) ions were synthesized and screened for the antiinflammatory and antiulcer activity.	2-substituted aniline	46-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-124
2851332-5	1988	Relaxation rates for the complexes E.CoATP, E.CoGTP, and E.CoGDP were shown to depend on Co(II)-31P distances.	cogtp	46-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-95
2851332-7	1988	At the center of these limits, the Co(II)-31P distances of beta-P and gamma-P in E.CoATP and E.CoGTP, and of beta-P (E.CoGDP), are in the range 3.1-3.5 A appropriate for the first coordination sphere.	beta-p	59-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-41
2851332-7	1988	At the center of these limits, the Co(II)-31P distances of beta-P and gamma-P in E.CoATP and E.CoGTP, and of beta-P (E.CoGDP), are in the range 3.1-3.5 A appropriate for the first coordination sphere.	gamma-p	70-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-41
2851332-7	1988	At the center of these limits, the Co(II)-31P distances of beta-P and gamma-P in E.CoATP and E.CoGTP, and of beta-P (E.CoGDP), are in the range 3.1-3.5 A appropriate for the first coordination sphere.	cogtp	95-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-41
2851332-7	1988	At the center of these limits, the Co(II)-31P distances of beta-P and gamma-P in E.CoATP and E.CoGTP, and of beta-P (E.CoGDP), are in the range 3.1-3.5 A appropriate for the first coordination sphere.	beta-p	109-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-41
2851332-7	1988	At the center of these limits, the Co(II)-31P distances of beta-P and gamma-P in E.CoATP and E.CoGTP, and of beta-P (E.CoGDP), are in the range 3.1-3.5 A appropriate for the first coordination sphere.	cogdp	119-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-41
3253183-0	1988	[Studies on the stability of ternary complexes of glycine and DL-alanine with Cu(II), Ni(II), Co(II) and Zn(II)].	Glycine	50-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-100
3253183-0	1988	[Studies on the stability of ternary complexes of glycine and DL-alanine with Cu(II), Ni(II), Co(II) and Zn(II)].	DL-ALANINE	62-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-100
3216199-6	1988	Based on the enthalpies, it is suggested that the order of combining affinity of these metal cations for phytic acid is Cu(II) greater than or equal to Zn(II) greater than or less than Cd(II) greater than Mn(II) greater than Mg(II) greater than Co(II) greater than Ni(II) The heats of precipitations (which includes binding, solvation changes, etc.)	Metals	87-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	245-251
3216199-6	1988	Based on the enthalpies, it is suggested that the order of combining affinity of these metal cations for phytic acid is Cu(II) greater than or equal to Zn(II) greater than or less than Cd(II) greater than Mn(II) greater than Mg(II) greater than Co(II) greater than Ni(II) The heats of precipitations (which includes binding, solvation changes, etc.)	Phytic Acid	105-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	245-251
3171870-0	1988	Stability constants of ampicillin complexes with Co(II) and Ni(II) ions.	Ampicillin	23-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-55
3335495-1	1988	An NMR study of the Cu(II), Co(II) derivative.	cu(ii)	20-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-34
3335495-2	1988	The Cu,Co superoxide dismutase derivative, in which the native Zn(II) was replaced by Co(II), was investigated by 1H NMR spectroscopy at pH 7.0 in the presence of CN- and N-3.	Copper	4-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-92
3122825-3	1987	Visible spectroscopy was used to measure the binding of imidazole and 1,2,4-triazole to Co(II)-substituted human CA I and active site carboxymethylated human CA I (CmCA I) and the binding of 1,2,4-triazole to bovine CoIICA II.	imidazole	56-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-94
3122825-3	1987	Visible spectroscopy was used to measure the binding of imidazole and 1,2,4-triazole to Co(II)-substituted human CA I and active site carboxymethylated human CA I (CmCA I) and the binding of 1,2,4-triazole to bovine CoIICA II.	1,2,4-triazole	70-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-94
3122825-3	1987	Visible spectroscopy was used to measure the binding of imidazole and 1,2,4-triazole to Co(II)-substituted human CA I and active site carboxymethylated human CA I (CmCA I) and the binding of 1,2,4-triazole to bovine CoIICA II.	1,2,4-triazole	191-205	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-94
3760863-1	1986	Fe(II), Fe(III), Co(II), and Ni(II) chelates with three quinolinol sulfonamides have been prepared and characterized.	quinolinol sulfonamides	56-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22
18963925-1	1985	Traces of silver and amounts up to 50 mg can be separated from up to gram amounts of Zn, Cu(II), Ni, Co(II), Mg, Be, Ti(IV), V(IV), Li and Na by eluting these with 2.0M nitric acid from a column containing 54 ml (20 g) of macroporous AG MP-50 cation-exchange resin of 100-200 mesh particle size, in the H(+)-form.	Silver	10-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-107
2999330-0	1985	Derivatives of Co(II), Co(III), Ni(II), Cu(II), and Zn(II) with 5" AMP.	Adenosine Monophosphate	67-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-21
2999330-2	1985	Some new derivatives of Co(II), Co(III), Ni(II), Cu(II), and Zn(II) with 5" AMP have been obtained, characterized by elemental analysis, infrared, electronic, and fluorescence spectroscopy.	cu(ii)	49-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-30
2999330-2	1985	Some new derivatives of Co(II), Co(III), Ni(II), Cu(II), and Zn(II) with 5" AMP have been obtained, characterized by elemental analysis, infrared, electronic, and fluorescence spectroscopy.	Zinc	61-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-30
2999330-2	1985	Some new derivatives of Co(II), Co(III), Ni(II), Cu(II), and Zn(II) with 5" AMP have been obtained, characterized by elemental analysis, infrared, electronic, and fluorescence spectroscopy.	Adenosine Monophosphate	76-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-30
3768320-1	1986	The distance between the calcium site (site I) and the zinc site (site II) in alpha-lactalbumin was estimated from Forster energy-transfer measurements between donor Eu(III) [or Tb(III)] at site I and acceptor Co(II) at site II to be 11.5 +/- 1.5 A. Intersite distances were also measured between the bis-ANS [4,4"-bis[1-(phenylamino)-8-naphthalenesulfonate]] binding locus and cobalt at site II (13.6 +/- 1.0 A), between bis-ANS and a fluorescein moiety covalently bound to Met-90 (33.5 +/- 3.0 A), and between Met-90 (fluorescein) and cobalt at site II (16.7 +/- 1.0 A).	Calcium	25-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	210-216
3722145-5	1986	It is also noted that the effect of the "extra" electron in the nitrogen base Co(II) oxy complexes, in some ways, parallels the effect of the lone pair electrons of thiolate in the oxy-P-450cam complex.	Nitrogen	64-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-84
3722145-5	1986	It is also noted that the effect of the "extra" electron in the nitrogen base Co(II) oxy complexes, in some ways, parallels the effect of the lone pair electrons of thiolate in the oxy-P-450cam complex.	thiolate	165-173	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-84
3722145-5	1986	It is also noted that the effect of the "extra" electron in the nitrogen base Co(II) oxy complexes, in some ways, parallels the effect of the lone pair electrons of thiolate in the oxy-P-450cam complex.	oxy-p	181-186	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-84
3722145-6	1986	This is evidenced by the enhanced resonance Raman activity of vo-o in both the Co(II) and P-450 systems as well as by the similarity of the vo-o frequencies.	vo-o	62-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-85
3006777-2	1986	No disturbance of the EPR signal of the tubulin-bound allocolchicine spin probe could be observed at room temperature in the presence of other paramagnetic probes: Mn(II) for the binding site of Mg(II), Co(II) for the Zn(II) binding site and Cr(III)GTP for the binding site of the exchangeable GTP.	Zinc	218-224	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	203-209
2419330-2	1986	Antibodies against the COOH-terminal undecapeptide of COII (anti-COII-C), when incubated with a Triton X-100 mitochondrial lysate from HeLa cells pulse-labeled with [35S]methionine under conditions selective for mitochondrial protein synthesis and chased for 18 h in unlabeled medium, precipitated the pulse-labeled three largest subunits (mitochondrially synthesized) of cytochrome c oxidase in proportions close to equimolarity.	Octoxynol	96-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-58
2419330-2	1986	Antibodies against the COOH-terminal undecapeptide of COII (anti-COII-C), when incubated with a Triton X-100 mitochondrial lysate from HeLa cells pulse-labeled with [35S]methionine under conditions selective for mitochondrial protein synthesis and chased for 18 h in unlabeled medium, precipitated the pulse-labeled three largest subunits (mitochondrially synthesized) of cytochrome c oxidase in proportions close to equimolarity.	Octoxynol	96-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-69
2419330-2	1986	Antibodies against the COOH-terminal undecapeptide of COII (anti-COII-C), when incubated with a Triton X-100 mitochondrial lysate from HeLa cells pulse-labeled with [35S]methionine under conditions selective for mitochondrial protein synthesis and chased for 18 h in unlabeled medium, precipitated the pulse-labeled three largest subunits (mitochondrially synthesized) of cytochrome c oxidase in proportions close to equimolarity.	Sulfur-35	166-169	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-58
2419330-2	1986	Antibodies against the COOH-terminal undecapeptide of COII (anti-COII-C), when incubated with a Triton X-100 mitochondrial lysate from HeLa cells pulse-labeled with [35S]methionine under conditions selective for mitochondrial protein synthesis and chased for 18 h in unlabeled medium, precipitated the pulse-labeled three largest subunits (mitochondrially synthesized) of cytochrome c oxidase in proportions close to equimolarity.	Methionine	170-180	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-58
2419330-3	1986	Antibodies against the NH2-terminal decapeptide of COII (anti-COII-N), although equally reactive as the anti-COII-C antibodies with the sodium dodecyl sulfate-solubilized COII, did not precipitate any of the three labeled subunits from the Triton X-100 mitochondrial lysate.	Octoxynol	240-252	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-55
3002884-3	1986	There appears to be an additional transition metal-binding site on clostridiopeptidase A, accepting Zn(II), which is inhibitory (Ki = 550 microM), or Co(II), which is stimulatory (Kact = 200 microM).	Metals	45-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	150-156
3562268-2	1986	The results indicate that the longer wavelength emission of poly A is quenched by not only Co(II) and Ni(II) but also Mg(II).	Poly A	60-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-97
2998477-2	1985	Co(II) ions react with hydrogen peroxide under physiological conditions to form a "reactive species" that can hydroxylate aromatic compounds (phenol and salicylate) and degrade deoxyribose to thiobarbituric-acid-reactive material.	Hydrogen Peroxide	23-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
2998477-2	1985	Co(II) ions react with hydrogen peroxide under physiological conditions to form a "reactive species" that can hydroxylate aromatic compounds (phenol and salicylate) and degrade deoxyribose to thiobarbituric-acid-reactive material.	Phenol	142-148	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
2998477-2	1985	Co(II) ions react with hydrogen peroxide under physiological conditions to form a "reactive species" that can hydroxylate aromatic compounds (phenol and salicylate) and degrade deoxyribose to thiobarbituric-acid-reactive material.	Salicylates	153-163	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
2998477-2	1985	Co(II) ions react with hydrogen peroxide under physiological conditions to form a "reactive species" that can hydroxylate aromatic compounds (phenol and salicylate) and degrade deoxyribose to thiobarbituric-acid-reactive material.	Deoxyribose	177-188	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
2998477-2	1985	Co(II) ions react with hydrogen peroxide under physiological conditions to form a "reactive species" that can hydroxylate aromatic compounds (phenol and salicylate) and degrade deoxyribose to thiobarbituric-acid-reactive material.	thiobarbituric acid	192-211	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
2998477-4	1985	EDTA, present in excess over the Co(II), can accelerate deoxyribose degradation and aromatic hydroxylation.	Edetic Acid	0-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-39
2998477-4	1985	EDTA, present in excess over the Co(II), can accelerate deoxyribose degradation and aromatic hydroxylation.	Deoxyribose	56-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-39
18964002-3	1985	In the extraction equilibrium of Co(II) the rate-determining step seems to be the complexation of hydrated Co(II) by BP in the aqueous phase.	Benzo(a)pyrene	117-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-39
18964002-3	1985	In the extraction equilibrium of Co(II) the rate-determining step seems to be the complexation of hydrated Co(II) by BP in the aqueous phase.	Benzo(a)pyrene	117-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-113
3890940-5	1985	Substitution of Co(II) for Zn(II) causes a decrease in the Eu(III) fluorescence lifetime.	Zinc	27-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-22
2990529-1	1985	Using 13C NMR spectroscopy, we have further investigated the binding of HCO3- in the active site of an artificial form of human carbonic anhydrase I in which the native zinc is replaced by Co(II).	Bicarbonates	72-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	189-195
2990529-2	1985	The Co(II) enzyme, unlike all other metal-substituted derivatives, has functional properties closely similar to those of the native zinc enzyme.	Metals	36-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
2990529-4	1985	The following are the results at 14 degrees C and pH 6.3 (1) HCO3- is bound in the active site of the catalytically competent enzyme with the 13C of the HCO3- located 3.22 +/- 0.02 A from the Co(II); (2) the apparent equilibrium dissociation constant for the bound HCO3- is 7.6 +/- 1.5 mM, determined by using the paramagnetic effects on the line widths, and 10 +/- 2 mM, determined by using the exchange effects; (3) the lifetime of HCO3- bound to the metal is (4.4 +/- 0.4) X 10(-5) s; (4) the overall catalyzed CO2 in equilibrium HCO3- exchange rate constant of the Co(II) enzyme is (9.6 +/- 0.4) X 10(3) s-1; (5) the electron spin relaxation time of the Co(II), determined by using paramagnetic effects on the bound HCO3-, is (1.1 +/- 0.1) X 10(-11) s. The data did not provide any direct information on the binding of CO2.	Bicarbonates	61-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	192-199
2990529-4	1985	The following are the results at 14 degrees C and pH 6.3 (1) HCO3- is bound in the active site of the catalytically competent enzyme with the 13C of the HCO3- located 3.22 +/- 0.02 A from the Co(II); (2) the apparent equilibrium dissociation constant for the bound HCO3- is 7.6 +/- 1.5 mM, determined by using the paramagnetic effects on the line widths, and 10 +/- 2 mM, determined by using the exchange effects; (3) the lifetime of HCO3- bound to the metal is (4.4 +/- 0.4) X 10(-5) s; (4) the overall catalyzed CO2 in equilibrium HCO3- exchange rate constant of the Co(II) enzyme is (9.6 +/- 0.4) X 10(3) s-1; (5) the electron spin relaxation time of the Co(II), determined by using paramagnetic effects on the bound HCO3-, is (1.1 +/- 0.1) X 10(-11) s. The data did not provide any direct information on the binding of CO2.	Bicarbonates	61-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	192-198
2990529-4	1985	The following are the results at 14 degrees C and pH 6.3 (1) HCO3- is bound in the active site of the catalytically competent enzyme with the 13C of the HCO3- located 3.22 +/- 0.02 A from the Co(II); (2) the apparent equilibrium dissociation constant for the bound HCO3- is 7.6 +/- 1.5 mM, determined by using the paramagnetic effects on the line widths, and 10 +/- 2 mM, determined by using the exchange effects; (3) the lifetime of HCO3- bound to the metal is (4.4 +/- 0.4) X 10(-5) s; (4) the overall catalyzed CO2 in equilibrium HCO3- exchange rate constant of the Co(II) enzyme is (9.6 +/- 0.4) X 10(3) s-1; (5) the electron spin relaxation time of the Co(II), determined by using paramagnetic effects on the bound HCO3-, is (1.1 +/- 0.1) X 10(-11) s. The data did not provide any direct information on the binding of CO2.	Bicarbonates	61-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	569-575
2990529-4	1985	The following are the results at 14 degrees C and pH 6.3 (1) HCO3- is bound in the active site of the catalytically competent enzyme with the 13C of the HCO3- located 3.22 +/- 0.02 A from the Co(II); (2) the apparent equilibrium dissociation constant for the bound HCO3- is 7.6 +/- 1.5 mM, determined by using the paramagnetic effects on the line widths, and 10 +/- 2 mM, determined by using the exchange effects; (3) the lifetime of HCO3- bound to the metal is (4.4 +/- 0.4) X 10(-5) s; (4) the overall catalyzed CO2 in equilibrium HCO3- exchange rate constant of the Co(II) enzyme is (9.6 +/- 0.4) X 10(3) s-1; (5) the electron spin relaxation time of the Co(II), determined by using paramagnetic effects on the bound HCO3-, is (1.1 +/- 0.1) X 10(-11) s. The data did not provide any direct information on the binding of CO2.	13c	142-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	192-199
2990529-4	1985	The following are the results at 14 degrees C and pH 6.3 (1) HCO3- is bound in the active site of the catalytically competent enzyme with the 13C of the HCO3- located 3.22 +/- 0.02 A from the Co(II); (2) the apparent equilibrium dissociation constant for the bound HCO3- is 7.6 +/- 1.5 mM, determined by using the paramagnetic effects on the line widths, and 10 +/- 2 mM, determined by using the exchange effects; (3) the lifetime of HCO3- bound to the metal is (4.4 +/- 0.4) X 10(-5) s; (4) the overall catalyzed CO2 in equilibrium HCO3- exchange rate constant of the Co(II) enzyme is (9.6 +/- 0.4) X 10(3) s-1; (5) the electron spin relaxation time of the Co(II), determined by using paramagnetic effects on the bound HCO3-, is (1.1 +/- 0.1) X 10(-11) s. The data did not provide any direct information on the binding of CO2.	13c	142-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	192-198
2990529-4	1985	The following are the results at 14 degrees C and pH 6.3 (1) HCO3- is bound in the active site of the catalytically competent enzyme with the 13C of the HCO3- located 3.22 +/- 0.02 A from the Co(II); (2) the apparent equilibrium dissociation constant for the bound HCO3- is 7.6 +/- 1.5 mM, determined by using the paramagnetic effects on the line widths, and 10 +/- 2 mM, determined by using the exchange effects; (3) the lifetime of HCO3- bound to the metal is (4.4 +/- 0.4) X 10(-5) s; (4) the overall catalyzed CO2 in equilibrium HCO3- exchange rate constant of the Co(II) enzyme is (9.6 +/- 0.4) X 10(3) s-1; (5) the electron spin relaxation time of the Co(II), determined by using paramagnetic effects on the bound HCO3-, is (1.1 +/- 0.1) X 10(-11) s. The data did not provide any direct information on the binding of CO2.	13c	142-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	569-575
3890940-6	1985	Calculations based on Forster energy-transfer theory predict that the Co(II) [or Zn(II) in vivo] and Eu(III) [or Ca(II) in vivo] binding sites are separated by 9.6 +/- 0.5 A.	Zinc	81-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-76
3853074-5	1985	N-7 can become a ligand to many metal ions such as Os(VI) from OsO3 X (Py)2, Pt(II) from square-planar cis- or trans-dichlorodiammine complexes, Co(II), and Mn(II).	4-(4-fluorophenyl)-2-methyl-6-(5-piperidinopentyloxy)pyrimidine hydrochloride	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-150
3853074-5	1985	N-7 can become a ligand to many metal ions such as Os(VI) from OsO3 X (Py)2, Pt(II) from square-planar cis- or trans-dichlorodiammine complexes, Co(II), and Mn(II).	Metals	32-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-150
3853074-5	1985	N-7 can become a ligand to many metal ions such as Os(VI) from OsO3 X (Py)2, Pt(II) from square-planar cis- or trans-dichlorodiammine complexes, Co(II), and Mn(II).	Manganese(2+)	157-163	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-150
6400891-0	1983	Interaction of adenosine 5"-triphosphate with metal ions X-ray structure of ternary complexes containing Mg(II), Ca(II), Mn(II), Co(II), ATP and 2,2"-dipyridylamine.	Adenosine Triphosphate	15-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-135
6466647-4	1984	Electron paramagnetic resonance and absorption measurements of the Co(II) derivative are in agreement with the presence of a metal-thiolate cluster in this protein.	Metals	125-130	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-73
6466647-4	1984	Electron paramagnetic resonance and absorption measurements of the Co(II) derivative are in agreement with the presence of a metal-thiolate cluster in this protein.	thiolate	131-139	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-73
6322852-0	1984	Co(II) derivatives of Cu,Zn-superoxide dismutase with the cobalt bound in the place of copper.	Cobalt	58-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
6322852-0	1984	Co(II) derivatives of Cu,Zn-superoxide dismutase with the cobalt bound in the place of copper.	Copper	87-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
6322852-2	1984	Co(II) derivatives of Cu,Zn-superoxide dismutase having cobalt substituted for the copper (Co,Zn-superoxide dismutase and Co,Co-superoxide dismutase) were studied by optical and EPR spectroscopy.	Cobalt	56-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
6322852-2	1984	Co(II) derivatives of Cu,Zn-superoxide dismutase having cobalt substituted for the copper (Co,Zn-superoxide dismutase and Co,Co-superoxide dismutase) were studied by optical and EPR spectroscopy.	Copper	83-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
6322852-4	1984	This behaviour suggests that cobalt in Co,Zn-superoxide dismutase is open to solvent access, at variance with the Co(II) of the Cu,Co-superoxide dismutase, which is substituted for the Zn.	Cobalt	29-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-120
6322852-4	1984	This behaviour suggests that cobalt in Co,Zn-superoxide dismutase is open to solvent access, at variance with the Co(II) of the Cu,Co-superoxide dismutase, which is substituted for the Zn.	Zinc	42-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-120
6322852-13	1984	These results substantiate the contention that Co(II) can replace the copper of Cu,Zn-superoxide dismutase in a way that reproduces the properties of the native copper-binding site.	Copper	70-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-53
6322852-13	1984	These results substantiate the contention that Co(II) can replace the copper of Cu,Zn-superoxide dismutase in a way that reproduces the properties of the native copper-binding site.	Copper	161-167	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-53
6329671-7	1984	Thus, in Co(II)7-metallothionein, the Co(II)-specific ESR signals are effectively suppressed by antiferromagnetic coupling of juxtaposed paramagnetic metal ions.	Metals	17-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	9-15
6329671-10	1984	Up to binding of four equivalents of Co(II), the ESR amplitude increases in proportion to the metal content, indicating generation of magnetically noninteracting high-spin complexes.	Metals	94-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-43
6400891-0	1983	Interaction of adenosine 5"-triphosphate with metal ions X-ray structure of ternary complexes containing Mg(II), Ca(II), Mn(II), Co(II), ATP and 2,2"-dipyridylamine.	Metals	46-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-135
6314846-2	1983	N-(2-acetamido)iminodiacetic acid, 2:1 complexes with zinc(II), cobalt(II), nickel(II), and copper(II); amide deprotonation by Zn(II), Co(II), and Cu(II).	N-(2-acetamido)iminodiacetic acid	0-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-140
6313654-4	1983	However, the in-plane hyperfine coupling constants of deoxy meso-CoMb were more anisotropic and larger than those of deoxy proto-CoMb, suggesting an increase in the electron spin density on the Co(II) ion upon the exchange of protoporphyrin IX with mesoprophyrin IX.	protoporphyrin IX	226-243	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	194-200
6313654-4	1983	However, the in-plane hyperfine coupling constants of deoxy meso-CoMb were more anisotropic and larger than those of deoxy proto-CoMb, suggesting an increase in the electron spin density on the Co(II) ion upon the exchange of protoporphyrin IX with mesoprophyrin IX.	mesoprophyrin ix	249-265	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	194-200
6626154-10	1983	The formation of the "metachromatic complex" between Ret-P and Mn(II) or Co(II) inhibited the synthesis of retinyl phosphate mannose (Ret-P-Man) from exogenous and endogenous Ret-P and guanosine diphosphate [14C]mannose when bovine serum albumin was added after the metal ion.	Carbon-14	208-211	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-79
6626154-10	1983	The formation of the "metachromatic complex" between Ret-P and Mn(II) or Co(II) inhibited the synthesis of retinyl phosphate mannose (Ret-P-Man) from exogenous and endogenous Ret-P and guanosine diphosphate [14C]mannose when bovine serum albumin was added after the metal ion.	Mannose	125-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-79
6626154-10	1983	The formation of the "metachromatic complex" between Ret-P and Mn(II) or Co(II) inhibited the synthesis of retinyl phosphate mannose (Ret-P-Man) from exogenous and endogenous Ret-P and guanosine diphosphate [14C]mannose when bovine serum albumin was added after the metal ion.	Metals	266-271	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-79
6626154-10	1983	The formation of the "metachromatic complex" between Ret-P and Mn(II) or Co(II) inhibited the synthesis of retinyl phosphate mannose (Ret-P-Man) from exogenous and endogenous Ret-P and guanosine diphosphate [14C]mannose when bovine serum albumin was added after the metal ion.	mannosylretinylphosphate	107-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-79
6626154-10	1983	The formation of the "metachromatic complex" between Ret-P and Mn(II) or Co(II) inhibited the synthesis of retinyl phosphate mannose (Ret-P-Man) from exogenous and endogenous Ret-P and guanosine diphosphate [14C]mannose when bovine serum albumin was added after the metal ion.	Guanosine Diphosphate	185-206	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-79
6314846-2	1983	N-(2-acetamido)iminodiacetic acid, 2:1 complexes with zinc(II), cobalt(II), nickel(II), and copper(II); amide deprotonation by Zn(II), Co(II), and Cu(II).	Amides	104-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-140
6314846-2	1983	N-(2-acetamido)iminodiacetic acid, 2:1 complexes with zinc(II), cobalt(II), nickel(II), and copper(II); amide deprotonation by Zn(II), Co(II), and Cu(II).	cu(ii)	147-153	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-140
6314846-3	1983	Potentiometric, visible, infrared, electron spin, and nuclear magnetic resonance studies of the complexation of N-(2-acetamido)iminodiacetic acid (H2ADA) by Ca(II), Mg(II), Mn(II), Zn(II), Co(II), Ni(II), and Cu(II) are reported.	N-(2-acetamido)iminodiacetic acid	112-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	189-195
6314846-3	1983	Potentiometric, visible, infrared, electron spin, and nuclear magnetic resonance studies of the complexation of N-(2-acetamido)iminodiacetic acid (H2ADA) by Ca(II), Mg(II), Mn(II), Zn(II), Co(II), Ni(II), and Cu(II) are reported.	h2ada)	147-153	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	189-195
6314846-5	1983	Co(II) and Zn(II), but not Cu(II), were found to induce stepwise deprotonation of the amide groups to form [M(H-1ADA)4-(2)].	Amides	86-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
6280674-10	1981	By adding Co2+ ions to the vacant copper site of [Cu1--Zn2] a hybrid molecule containing Cu(II) on one subunit and Co(II) in the homologous site of the other subunit was prepared.	Cobalt(2+)	10-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-121
6863259-7	1983	For the two inverted repeats examined within pVH51, various divalent metal ions and spermidine resulted in the following hierarchy: Mn(II) less than Zn(II) less than Mg(II) less than Co(II) less than spermidine, where the transition midpoint was at lowest negative density values for Mn(II) and highest for spermidine.	Metals	69-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	183-189
6863259-7	1983	For the two inverted repeats examined within pVH51, various divalent metal ions and spermidine resulted in the following hierarchy: Mn(II) less than Zn(II) less than Mg(II) less than Co(II) less than spermidine, where the transition midpoint was at lowest negative density values for Mn(II) and highest for spermidine.	Spermidine	84-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	183-189
6863259-7	1983	For the two inverted repeats examined within pVH51, various divalent metal ions and spermidine resulted in the following hierarchy: Mn(II) less than Zn(II) less than Mg(II) less than Co(II) less than spermidine, where the transition midpoint was at lowest negative density values for Mn(II) and highest for spermidine.	Manganese(2+)	284-290	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	183-189
18963312-0	1983	Reactivity of potassium tetracyanomercurate with Ag(I), Ni(II) And Co(II).	potassium tetracyanomercurate	14-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-73
6186274-2	1982	Co(II) interacts with bleomycin in aqueous solution, in the presence of air, to give a short-lived mononuclear superoxo Co(III) complex (I).	Bleomycin	22-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
6186274-2	1982	Co(II) interacts with bleomycin in aqueous solution, in the presence of air, to give a short-lived mononuclear superoxo Co(III) complex (I).	co(iii)	120-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
18963222-0	1982	The solvent extraction of Cu(II), Ni(II) and Co(II) with benzil mono(2-quinolyl)hydrazone.	benzil mono(2-quinolyl)hydrazone	57-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-51
18963222-1	1982	Benzil mono(2-quinolyl)hydrazone, BmQH, has been studied as an extracting agent for Cu(II), Ni(II) and Co(II).	benzil mono(2-quinolyl)hydrazone	0-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-109
18963222-1	1982	Benzil mono(2-quinolyl)hydrazone, BmQH, has been studied as an extracting agent for Cu(II), Ni(II) and Co(II).	bmqh	34-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-109
7107362-0	1982	Electrochemical studies on nitroimidazole sensitizers: interaction with Co(II), Zn(II), and Fe(III) in biological media.	Nitroimidazoles	27-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-78
7107362-1	1982	Misonidazole and desmethylmisonidazole react in chemical systems with metal ions such as Zn(II), Co(II), Fe(II) and Fe(III).	Misonidazole	0-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-103
7107362-1	1982	Misonidazole and desmethylmisonidazole react in chemical systems with metal ions such as Zn(II), Co(II), Fe(II) and Fe(III).	desmethylmisonidazole	17-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-103
7107362-1	1982	Misonidazole and desmethylmisonidazole react in chemical systems with metal ions such as Zn(II), Co(II), Fe(II) and Fe(III).	Metals	70-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-103
6301689-2	1983	In particular, antibodies directed against either the NH2-terminal decapeptide or the COOH-terminal undecapeptide of cytochrome c oxidase subunit II (COII) were both very effective in immunoprecipitating the previously identified COII polypeptide from an SDS lysate of mitochondria from HeLa cells.	Sodium Dodecyl Sulfate	255-258	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-148
6301689-2	1983	In particular, antibodies directed against either the NH2-terminal decapeptide or the COOH-terminal undecapeptide of cytochrome c oxidase subunit II (COII) were both very effective in immunoprecipitating the previously identified COII polypeptide from an SDS lysate of mitochondria from HeLa cells.	Sodium Dodecyl Sulfate	255-258	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	150-154
6301689-2	1983	In particular, antibodies directed against either the NH2-terminal decapeptide or the COOH-terminal undecapeptide of cytochrome c oxidase subunit II (COII) were both very effective in immunoprecipitating the previously identified COII polypeptide from an SDS lysate of mitochondria from HeLa cells.	Sodium Dodecyl Sulfate	255-258	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	230-234
6288708-7	1982	The kinetic parameters Km and Vmax for the pyridoxal kinase reaction were determined for ATP and the diastereomers of ATP beta S in the presence of Mg(II), Co(II), Zn(II), and Cd(II).	Adenosine Triphosphate	89-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	156-162
6288708-7	1982	The kinetic parameters Km and Vmax for the pyridoxal kinase reaction were determined for ATP and the diastereomers of ATP beta S in the presence of Mg(II), Co(II), Zn(II), and Cd(II).	adenosine 5'-O-(2-thiotriphosphate)	118-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	156-162
6288708-10	1982	As the divalent cations were varied in the series Mg(II), Co(II), Zn(II), and Cd(II), the A/B ratio was progressively lowered to the value of 0.2 found for Cd(II).	cd(ii)	156-162	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-64
7107362-3	1982	Other experiments demonstrate that Co(II) and Zn(II) react differently with the nitroimidazoles when these reactions are studied in 20% serum solutions.	Nitroimidazoles	80-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-41
6280674-10	1981	By adding Co2+ ions to the vacant copper site of [Cu1--Zn2] a hybrid molecule containing Cu(II) on one subunit and Co(II) in the homologous site of the other subunit was prepared.	Copper	34-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-121
6794641-1	1981	X-ray absorption near-edge spectroscopy (XANES) of Co(II) in three derivatives of superoxide dismutase, namely [Cu(II)-Co(II)], [Cu(I)-Co(II)] and [...-Co(II)], suggests a tetrahedral coordination of the metal for all compounds.	Metals	204-209	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-57
6794641-0	1981	X-ray absorption edge spectroscopy of Co(II)-binding sites of copper- and zinc-containing proteins.	Copper	62-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-44
6794641-2	1981	Significant differences, detected in the spectrum of the [Cu(II)-Co(II)] derivative as compared to the other species, indicate that a conformational change and/or a different charge of the imidazole bridging the two metal sites in superoxide dismutase occur in coincidence with the change of copper valence.	cu(ii)	58-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-71
6794641-1	1981	X-ray absorption near-edge spectroscopy (XANES) of Co(II) in three derivatives of superoxide dismutase, namely [Cu(II)-Co(II)], [Cu(I)-Co(II)] and [...-Co(II)], suggests a tetrahedral coordination of the metal for all compounds.	xanes	41-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-57
6794641-2	1981	Significant differences, detected in the spectrum of the [Cu(II)-Co(II)] derivative as compared to the other species, indicate that a conformational change and/or a different charge of the imidazole bridging the two metal sites in superoxide dismutase occur in coincidence with the change of copper valence.	imidazole	189-198	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-71
6794641-1	1981	X-ray absorption near-edge spectroscopy (XANES) of Co(II) in three derivatives of superoxide dismutase, namely [Cu(II)-Co(II)], [Cu(I)-Co(II)] and [...-Co(II)], suggests a tetrahedral coordination of the metal for all compounds.	cu(ii)	112-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-57
6794641-2	1981	Significant differences, detected in the spectrum of the [Cu(II)-Co(II)] derivative as compared to the other species, indicate that a conformational change and/or a different charge of the imidazole bridging the two metal sites in superoxide dismutase occur in coincidence with the change of copper valence.	Metals	216-221	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-71
6794641-2	1981	Significant differences, detected in the spectrum of the [Cu(II)-Co(II)] derivative as compared to the other species, indicate that a conformational change and/or a different charge of the imidazole bridging the two metal sites in superoxide dismutase occur in coincidence with the change of copper valence.	Copper	292-298	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-71
6164390-1	1981	We have studied the Cu(II), Co(II), and Fe(III) complexes of the antineoplastic drug bleomycin by using electron spin--echo envelope spectroscopy.	Bleomycin	85-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
7309708-3	1981	The various spectral data indicated that the Co(II) center has tetrahedral geometry (high-spin state) and is linked by two nitrogens and two oxygens.	Nitrogen	123-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-51
7309708-3	1981	The various spectral data indicated that the Co(II) center has tetrahedral geometry (high-spin state) and is linked by two nitrogens and two oxygens.	Oxygen	141-148	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-51
7284482-4	1981	In the presence of Co(II) ions (the molar ratio of N-acetyl-L-methionine/Co(II) was 100:1) the reaction velocity was increased.	N-acetylmethionine	51-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-25
7284482-4	1981	In the presence of Co(II) ions (the molar ratio of N-acetyl-L-methionine/Co(II) was 100:1) the reaction velocity was increased.	N-acetylmethionine	51-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-79
6164390-3	1981	For the Cu(II)-- and Co(II)--drug complexes, we have been able to identify imidazole as a metal ligand.	imidazole	75-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-26
6164390-3	1981	For the Cu(II)-- and Co(II)--drug complexes, we have been able to identify imidazole as a metal ligand.	Metals	90-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-26
6969292-4	1980	The stoichiometric dissociation constants for Co(II) binding to beta-lactamase II were estimated to be 0.13 and 2.66 mM (pH 6.0, 4 degrees C, 1 M NaCl) by equilibrium dialysis.	Sodium Chloride	146-150	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-52
6452896-7	1981	One Co(II) ion can be removed preferentially by incubation with KCN at high pH, indicating the two ions not to be in an identical environment.	Potassium Cyanide	64-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
6969292-5	1980	Competition between Zn(II) and Co(II) for the first metal binding site suggests a value of 0.7 microM (pH 6.0, 30 degrees C, 1 M NaCl) for the dissociation constant of Zn(II).	Metals	52-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-37
6969292-5	1980	Competition between Zn(II) and Co(II) for the first metal binding site suggests a value of 0.7 microM (pH 6.0, 30 degrees C, 1 M NaCl) for the dissociation constant of Zn(II).	Sodium Chloride	129-133	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-37
6969292-5	1980	Competition between Zn(II) and Co(II) for the first metal binding site suggests a value of 0.7 microM (pH 6.0, 30 degrees C, 1 M NaCl) for the dissociation constant of Zn(II).	Zinc	168-174	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-37
6969292-6	1980	The electronic spectra of the Co(II) enzyme lead to the suggestion that the coordination geometries around the metal ions in the first and second sites are related to those of a distorted tetrahedron and octahedron, respectively.	Metals	111-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-36
7451415-2	1980	The amount of cobalt(II) introduced into apohemocyanin reached 47% of the total sites for copper ion in native hemocyanin, being estimated as nearly complete formation of the half-filled cobalt(II)-hemocyanin (Co(II)-Hc).	Cobalt(2+)	14-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	210-216
7451415-2	1980	The amount of cobalt(II) introduced into apohemocyanin reached 47% of the total sites for copper ion in native hemocyanin, being estimated as nearly complete formation of the half-filled cobalt(II)-hemocyanin (Co(II)-Hc).	apohemocyanin	41-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	210-216
7451415-2	1980	The amount of cobalt(II) introduced into apohemocyanin reached 47% of the total sites for copper ion in native hemocyanin, being estimated as nearly complete formation of the half-filled cobalt(II)-hemocyanin (Co(II)-Hc).	Cobalt(2+)	187-197	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	210-216
7451415-3	1980	The Co(II)-Hc did not bind oxygen molecule even under O2-atmosphere.	Hydrocortisone	11-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
6966941-3	1980	Among a variety of complexes studied the perchlorate tris-o-phenanthroline complex Co(II) and the chloride 4,7-diphenyl-o-phenanthroline complex Cu(II) were found to have the highest activity.	perchlorate tris-o-phenanthroline	41-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-89
6821370-3	1980	Analysis of the spectra suggests that Co(II) binds at the same two metal-binding sites as does Zn(II).	Metals	67-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-44
6821370-4	1980	The binding of Co(II) at the first site is much weaker than the binding of Zn(II) at this site, whereas the binding of Co(II) at the second site is tighter than the binding of Zn(II).	Zinc	75-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-125
6821370-4	1980	The binding of Co(II) at the first site is much weaker than the binding of Zn(II) at this site, whereas the binding of Co(II) at the second site is tighter than the binding of Zn(II).	Zinc	176-182	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-21
6821370-4	1980	The binding of Co(II) at the first site is much weaker than the binding of Zn(II) at this site, whereas the binding of Co(II) at the second site is tighter than the binding of Zn(II).	Zinc	176-182	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-125
6821370-5	1980	The binding of Co(II) to the mono-zinc(II)-enzyme caused only one marked change in the spectrum, namely a decrease in the intensity of the resonances assigned to the C-2 and C-4 protons of one histidine residue (residue E).	mono-zinc(ii)	29-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-21
6821370-5	1980	The binding of Co(II) to the mono-zinc(II)-enzyme caused only one marked change in the spectrum, namely a decrease in the intensity of the resonances assigned to the C-2 and C-4 protons of one histidine residue (residue E).	Histidine	193-202	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-21
6821370-7	1980	A significant fraction of the protons in the whole molecule are affected by the binding of Co(II) at the first metal-ion-binding site (where the ligands are the enzyme"s sole thiol group and three histidine residues).	Metals	111-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-97
6821370-7	1980	A significant fraction of the protons in the whole molecule are affected by the binding of Co(II) at the first metal-ion-binding site (where the ligands are the enzyme"s sole thiol group and three histidine residues).	Sulfhydryl Compounds	175-180	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-97
6821370-7	1980	A significant fraction of the protons in the whole molecule are affected by the binding of Co(II) at the first metal-ion-binding site (where the ligands are the enzyme"s sole thiol group and three histidine residues).	Histidine	197-206	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-97
93598-3	1979	The results of potentiometric titration also indicate that the stability of bleomycin-metal complexes is in the order Fe(II) less than Co(II) less than Ni(II) less than Cu(II) greater than Zn(II) and that these divalent metal complexes have a similar coordination environment.	Bleomycin	76-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-141
93598-3	1979	The results of potentiometric titration also indicate that the stability of bleomycin-metal complexes is in the order Fe(II) less than Co(II) less than Ni(II) less than Cu(II) greater than Zn(II) and that these divalent metal complexes have a similar coordination environment.	Metals	86-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-141
45395-10	1979	Ni(II) and Co(II) are more effective than Mn(II) in quenching the fluorescence of ethenoadenosine phosphates; this result is predicted by Forster"s theory for energy transfer based upon the overlap between donor emission spectrum and acceptor absorption spectrum.	ethenoadenosine phosphates	82-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-17
80226-5	1978	Cu(II), Zn(II), and Co(II) inhibit degradation of DNA by bleomycin and Fe(II) in the absence of added reducing agents.	Bleomycin	57-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-26
36445-0	1979	A comparative study of Zn(II) and Co(II) binding to glycyl-L-tyrosine, a pseudosubstrate for carboxypeptidase A.	glycyltyrosine	52-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-40
36445-1	1979	A comprehensive investigation of the interaction of Zn(II) and Co(II) with the dipeptide glycyl-L-tyrosine has been carried out.	Dipeptides	79-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-69
36445-1	1979	A comprehensive investigation of the interaction of Zn(II) and Co(II) with the dipeptide glycyl-L-tyrosine has been carried out.	glycyltyrosine	89-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-69
36445-8	1979	In the Co(II) system, these correspond to amide protons.	Amides	42-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	7-13
80226-5	1978	Cu(II), Zn(II), and Co(II) inhibit degradation of DNA by bleomycin and Fe(II) in the absence of added reducing agents.	ammonium ferrous sulfate	71-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-26
28274-12	1978	Acceleration in ethanol at 25 degrees C is also observed with AgI, CuI, CuII, ZnII, FeIII and CoII salts, among others, with substantial amounts of N-nitrosamine being produced in ca.	Ethanol	16-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-98
204363-1	1978	Photolysis of a frozen (80--200 K) anaerobic solution of 5"-deoxyadenosyl-cobalamin in aqueous propan-1,2-diol produces only a small Co(II) signal detectable by electron paramagnetic resonance (EPR).	cobamamide	57-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	133-138
25562-0	1978	[Complex compounds of Co(II) with (disalicylidene)-ethylenediamine].	disalicylaldehyde ethylenediamine	34-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-28
117692-1	1978	In the present study use was made of the chelating ability of EDTA and the activating property of some metal ions Ca(II), Mg(II) or Mn(II) to counteract the inhibitory effect of Cu(II), Co(II), Pb(II) or Zn(II) ions on the B6-dependent kynurenine hydrolase and on kynurenine aminotransferase.	Edetic Acid	62-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	186-192
117692-1	1978	In the present study use was made of the chelating ability of EDTA and the activating property of some metal ions Ca(II), Mg(II) or Mn(II) to counteract the inhibitory effect of Cu(II), Co(II), Pb(II) or Zn(II) ions on the B6-dependent kynurenine hydrolase and on kynurenine aminotransferase.	Metals	103-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	186-192
117692-1	1978	In the present study use was made of the chelating ability of EDTA and the activating property of some metal ions Ca(II), Mg(II) or Mn(II) to counteract the inhibitory effect of Cu(II), Co(II), Pb(II) or Zn(II) ions on the B6-dependent kynurenine hydrolase and on kynurenine aminotransferase.	mg(ii)	122-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	186-192
117692-1	1978	In the present study use was made of the chelating ability of EDTA and the activating property of some metal ions Ca(II), Mg(II) or Mn(II) to counteract the inhibitory effect of Cu(II), Co(II), Pb(II) or Zn(II) ions on the B6-dependent kynurenine hydrolase and on kynurenine aminotransferase.	Manganese(2+)	132-138	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	186-192
117692-1	1978	In the present study use was made of the chelating ability of EDTA and the activating property of some metal ions Ca(II), Mg(II) or Mn(II) to counteract the inhibitory effect of Cu(II), Co(II), Pb(II) or Zn(II) ions on the B6-dependent kynurenine hydrolase and on kynurenine aminotransferase.	Zinc	204-210	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	186-192
117692-3	1978	EDTA was able to counteract the inhibitory effect of Cu(II) or Co(II) on kynurenine aminotransferase and partially counteract the inhibitory effect of Cu(II), Co(II) on kynurenine aminotransferase and partially counteract the inhibitory effect of Cu(II), Co(II), Pb(II) or Zn(II) ions on kynurenine hydrolase.	Edetic Acid	0-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-69
117692-3	1978	EDTA was able to counteract the inhibitory effect of Cu(II) or Co(II) on kynurenine aminotransferase and partially counteract the inhibitory effect of Cu(II), Co(II) on kynurenine aminotransferase and partially counteract the inhibitory effect of Cu(II), Co(II), Pb(II) or Zn(II) ions on kynurenine hydrolase.	Edetic Acid	0-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	159-165
117692-3	1978	EDTA was able to counteract the inhibitory effect of Cu(II) or Co(II) on kynurenine aminotransferase and partially counteract the inhibitory effect of Cu(II), Co(II) on kynurenine aminotransferase and partially counteract the inhibitory effect of Cu(II), Co(II), Pb(II) or Zn(II) ions on kynurenine hydrolase.	Edetic Acid	0-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	159-165
117692-3	1978	EDTA was able to counteract the inhibitory effect of Cu(II) or Co(II) on kynurenine aminotransferase and partially counteract the inhibitory effect of Cu(II), Co(II) on kynurenine aminotransferase and partially counteract the inhibitory effect of Cu(II), Co(II), Pb(II) or Zn(II) ions on kynurenine hydrolase.	Zinc	273-279	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	159-165
117692-3	1978	EDTA was able to counteract the inhibitory effect of Cu(II) or Co(II) on kynurenine aminotransferase and partially counteract the inhibitory effect of Cu(II), Co(II) on kynurenine aminotransferase and partially counteract the inhibitory effect of Cu(II), Co(II), Pb(II) or Zn(II) ions on kynurenine hydrolase.	Zinc	273-279	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	159-165
18962166-1	1977	In neutral unbuffered solutions containing dissolved oxygen, the normal pulse polarograms of certain metal ions [Pb(II), Cd(II), Zn(II), Co(II) and Mn(II)] produce peaks on the limiting plateaux.	Oxygen	53-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-143
922038-4	1977	Since 35S-labeled 2-mercaptoethanol is not part of the adduct, the reduction of the corrinoid from the Co(III) to the Co(II) form is a prerequisite for the reaction.	Corrinoids	84-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-124
18962166-1	1977	In neutral unbuffered solutions containing dissolved oxygen, the normal pulse polarograms of certain metal ions [Pb(II), Cd(II), Zn(II), Co(II) and Mn(II)] produce peaks on the limiting plateaux.	Metals	101-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-143
182215-6	1976	The quaternary adducts formed by H2O2 oxidation in the presence of aspartokinase, Co(II), ATP, aspartate, and threonine comprised a mixture of both ezyme-Co(III)-ATP-aspartate and enzyme-Co(III)-ATP-threonine adducts.	co(iii)	154-161	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
18212-0	1977	Studies of Zn(II) and Co(II) complexes of imidazole and n-methylimidazole with regard to the activity related ionization in carbonic anhydrase.	imidazole	42-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-28
18212-0	1977	Studies of Zn(II) and Co(II) complexes of imidazole and n-methylimidazole with regard to the activity related ionization in carbonic anhydrase.	1-methylimidazole	56-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-28
18212-1	1977	Mixed aquo-N-methylimidazole complexes of Co(II) have been studied as a function of pH to gain a fuller understanding of the metal-binding site in Co(II)-carbonic anhydrase.	aquo-n-methylimidazole	6-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-48
18212-1	1977	Mixed aquo-N-methylimidazole complexes of Co(II) have been studied as a function of pH to gain a fuller understanding of the metal-binding site in Co(II)-carbonic anhydrase.	Metals	125-130	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-153
18212-2	1977	The inherent affinity of N-methylimidazole for Co(II) has been calculated along with a species distribution for the stepwise addition of ligand to the metal ion.	1-methylimidazole	25-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-53
18212-5	1977	However, at high pH, Co(II)-N-methylimidazole complexes interact directly with the hydroxide ion, generating species with visible spectra very similar to that of Co(II)-carbonic anhydrase.	hydroxide ion	83-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-27
18212-5	1977	However, at high pH, Co(II)-N-methylimidazole complexes interact directly with the hydroxide ion, generating species with visible spectra very similar to that of Co(II)-carbonic anhydrase.	hydroxide ion	83-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	162-168
182215-3	1976	Co(III) exchange-inert adducts of aspartokinase and inhibitor or substrates were produced in situ by oxidation of Co(II) with H2O2.	Hydrogen Peroxide	126-130	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
182215-6	1976	The quaternary adducts formed by H2O2 oxidation in the presence of aspartokinase, Co(II), ATP, aspartate, and threonine comprised a mixture of both ezyme-Co(III)-ATP-aspartate and enzyme-Co(III)-ATP-threonine adducts.	Hydrogen Peroxide	33-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
182215-6	1976	The quaternary adducts formed by H2O2 oxidation in the presence of aspartokinase, Co(II), ATP, aspartate, and threonine comprised a mixture of both ezyme-Co(III)-ATP-aspartate and enzyme-Co(III)-ATP-threonine adducts.	Adenosine Triphosphate	162-165	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
182215-6	1976	The quaternary adducts formed by H2O2 oxidation in the presence of aspartokinase, Co(II), ATP, aspartate, and threonine comprised a mixture of both ezyme-Co(III)-ATP-aspartate and enzyme-Co(III)-ATP-threonine adducts.	Aspartic Acid	166-175	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
182215-6	1976	The quaternary adducts formed by H2O2 oxidation in the presence of aspartokinase, Co(II), ATP, aspartate, and threonine comprised a mixture of both ezyme-Co(III)-ATP-aspartate and enzyme-Co(III)-ATP-threonine adducts.	co(iii)	187-194	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
182215-6	1976	The quaternary adducts formed by H2O2 oxidation in the presence of aspartokinase, Co(II), ATP, aspartate, and threonine comprised a mixture of both ezyme-Co(III)-ATP-aspartate and enzyme-Co(III)-ATP-threonine adducts.	Adenosine Triphosphate	162-165	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
182215-6	1976	The quaternary adducts formed by H2O2 oxidation in the presence of aspartokinase, Co(II), ATP, aspartate, and threonine comprised a mixture of both ezyme-Co(III)-ATP-aspartate and enzyme-Co(III)-ATP-threonine adducts.	Threonine	199-208	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
237269-4	1975	The maximum polarographic effect is attained at urea concentrations of about 5-6 M. Quite generally, the appearance of a second Brdicka wave is attributed to complexation of Co(II) with S- and a group of ligands that is different on the second than on the first wave.	Urea	48-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	174-180
18961855-1	1976	The reaction of Co(II), pyridine-2-aldehyde-2-pyridyl hydrazone (PAPHY) and eosin at pH 5.6 produces the ternary complex Co(L)(HL)E(2) (where HL represents the protonated form of the ligand and E represents the eosinate anion).	PAPHY	65-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-21
18961855-1	1976	The reaction of Co(II), pyridine-2-aldehyde-2-pyridyl hydrazone (PAPHY) and eosin at pH 5.6 produces the ternary complex Co(L)(HL)E(2) (where HL represents the protonated form of the ligand and E represents the eosinate anion).	co(l)(hl)	121-130	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-21
18961855-1	1976	The reaction of Co(II), pyridine-2-aldehyde-2-pyridyl hydrazone (PAPHY) and eosin at pH 5.6 produces the ternary complex Co(L)(HL)E(2) (where HL represents the protonated form of the ligand and E represents the eosinate anion).	eosinate anion	211-225	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-21
18961830-2	1976	Zn, Ni, Cu(II), Mn(II), Co(II), Mg, Ca, Al, Fe(III), Ga and U(VI) by adsorbing these elements on a column of AG50W-X8 sulphonated polystyrene cation-exchange resin from 0.1M HCl containing 60% v v acetone, while Au(III) passes through and can be eluted with the same reagent.	ag50w	109-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-30
1061067-2	1975	Treatment with N-bromosuccinimide quenches enzyme tryptophan and Tb(III) fluorescence to a similar extent and suggests the operation of tryptophan vector Tb(III) vector Co(II) energy relay system in the enzyme.	Bromosuccinimide	15-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	169-175
1061067-2	1975	Treatment with N-bromosuccinimide quenches enzyme tryptophan and Tb(III) fluorescence to a similar extent and suggests the operation of tryptophan vector Tb(III) vector Co(II) energy relay system in the enzyme.	Tryptophan	50-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	169-175
1061067-2	1975	Treatment with N-bromosuccinimide quenches enzyme tryptophan and Tb(III) fluorescence to a similar extent and suggests the operation of tryptophan vector Tb(III) vector Co(II) energy relay system in the enzyme.	tb(iii)	65-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	169-175
1061067-2	1975	Treatment with N-bromosuccinimide quenches enzyme tryptophan and Tb(III) fluorescence to a similar extent and suggests the operation of tryptophan vector Tb(III) vector Co(II) energy relay system in the enzyme.	Tryptophan	136-146	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	169-175
1061067-3	1975	Dipoledipole radiationless energy transfer between the Tb(III) donor and the Co(II) acceptor can account for this quenching.	dipoledipole	0-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-83
1061067-3	1975	Dipoledipole radiationless energy transfer between the Tb(III) donor and the Co(II) acceptor can account for this quenching.	tb(iii)	55-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-83
240709-2	1975	At pH 4.6 the addition of Co(II), Cd(II) or Mn(II) to the apoenzyme results in a destabilization of the native protein conformation, but in the range of pH 5.5--8.8 these metal ions, and Zn(II), slightly increase the conformational stability of the protein, in so far as they reduce the probability phi of solvent exposure of the peptide groups.	Metals	171-176	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-32
240709-2	1975	At pH 4.6 the addition of Co(II), Cd(II) or Mn(II) to the apoenzyme results in a destabilization of the native protein conformation, but in the range of pH 5.5--8.8 these metal ions, and Zn(II), slightly increase the conformational stability of the protein, in so far as they reduce the probability phi of solvent exposure of the peptide groups.	Zinc	187-193	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-32
770424-7	1976	One hundred micrograms of Mn(II) per ml and possibly 10 mug of either Co(II) or  Ni(II) per ml could inhibit iron uptake in the deposition system.	Iron	109-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-76
941698-0	1976	[Chelate compounds of 3-methyl-4-alpha-pyridyl-1,2,4-triazolethiol-5 with Cu(II) and Co(II) ions].	3-methyl-4-alpha-pyridyl-1,2,4-triazolethiol-5	22-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-91
1276230-2	1976	Protonation constants and formation constants for the binding of L-Pyala, D,L-Pyala, D-Mepyala, and D,L-Mepyala with Cu(II), Ni(II), Co(II), and Zn(II) were determined by potentiometrictitration.	l-pyala	65-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	133-138
1276230-2	1976	Protonation constants and formation constants for the binding of L-Pyala, D,L-Pyala, D-Mepyala, and D,L-Mepyala with Cu(II), Ni(II), Co(II), and Zn(II) were determined by potentiometrictitration.	d,l-pyala	74-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	133-138
1276230-2	1976	Protonation constants and formation constants for the binding of L-Pyala, D,L-Pyala, D-Mepyala, and D,L-Mepyala with Cu(II), Ni(II), Co(II), and Zn(II) were determined by potentiometrictitration.	d-mepyala	85-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	133-138
1276230-2	1976	Protonation constants and formation constants for the binding of L-Pyala, D,L-Pyala, D-Mepyala, and D,L-Mepyala with Cu(II), Ni(II), Co(II), and Zn(II) were determined by potentiometrictitration.	d,l-mepyala	100-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	133-138
237269-4	1975	The maximum polarographic effect is attained at urea concentrations of about 5-6 M. Quite generally, the appearance of a second Brdicka wave is attributed to complexation of Co(II) with S- and a group of ligands that is different on the second than on the first wave.	Sulfur	186-187	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	174-180
237269-5	1975	The effect of calcium on Brdicka currents of bovine serum albumin in the absence of urea is attributed to an orientation of the protein on the surface of the electrode such that all disulfide groups are reduced and with other ligands can complex with Co(ii).	Calcium	14-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	251-257
164901-2	1975	Water relaxation studies at 8, 24, 100, and 220 MHz indicate two classes of bound Co(II).	Water	0-5	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-88
4376950-1	1974	Sulphonamide adducts of three Co(II) carbonic anhydrases were investigated by e.p.r.	Sulfonamides	0-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-36
164901-4	1975	Ethanol, acetaldehyde, and isobutyramide bind with appropriate affinities to the Co(II) substituted alcohol dehydrogenases decreasing the number of fast exchanging protons at the catalytic Co(II) site by greater than or equal to 54 percent.	Ethanol	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-87
164901-4	1975	Ethanol, acetaldehyde, and isobutyramide bind with appropriate affinities to the Co(II) substituted alcohol dehydrogenases decreasing the number of fast exchanging protons at the catalytic Co(II) site by greater than or equal to 54 percent.	Ethanol	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	189-195
164901-4	1975	Ethanol, acetaldehyde, and isobutyramide bind with appropriate affinities to the Co(II) substituted alcohol dehydrogenases decreasing the number of fast exchanging protons at the catalytic Co(II) site by greater than or equal to 54 percent.	Acetaldehyde	9-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-87
164901-4	1975	Ethanol, acetaldehyde, and isobutyramide bind with appropriate affinities to the Co(II) substituted alcohol dehydrogenases decreasing the number of fast exchanging protons at the catalytic Co(II) site by greater than or equal to 54 percent.	Acetaldehyde	9-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	189-195
164901-4	1975	Ethanol, acetaldehyde, and isobutyramide bind with appropriate affinities to the Co(II) substituted alcohol dehydrogenases decreasing the number of fast exchanging protons at the catalytic Co(II) site by greater than or equal to 54 percent.	isobutyramide	27-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-87
164901-4	1975	Ethanol, acetaldehyde, and isobutyramide bind with appropriate affinities to the Co(II) substituted alcohol dehydrogenases decreasing the number of fast exchanging protons at the catalytic Co(II) site by greater than or equal to 54 percent.	isobutyramide	27-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	189-195
164901-6	1975	The paramagnetic effects of Co(II) at the catalytic site on the relaxation rates of the methyl protons of isobutyramide at 100 and 220 MHz indicate that this analog binds at a site 9.1 A from the catalytic Co(II).	isobutyramide	106-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-34
164901-6	1975	The paramagnetic effects of Co(II) at the catalytic site on the relaxation rates of the methyl protons of isobutyramide at 100 and 220 MHz indicate that this analog binds at a site 9.1 A from the catalytic Co(II).	isobutyramide	106-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	206-212
164901-7	1975	This distance decreases to 6.9 A when NADH is bound, and a Co(II) to methyne proton distance of 6.6 A is determined indicating a conformation change leading to the formation of a second sphere enzyme-Co(II)-isobutyramide complex in which a hydroxyl or water ligand intervenes between the metal and the substrate analog.	NAD	38-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-64
164901-7	1975	This distance decreases to 6.9 A when NADH is bound, and a Co(II) to methyne proton distance of 6.6 A is determined indicating a conformation change leading to the formation of a second sphere enzyme-Co(II)-isobutyramide complex in which a hydroxyl or water ligand intervenes between the metal and the substrate analog.	NAD	38-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
164901-7	1975	This distance decreases to 6.9 A when NADH is bound, and a Co(II) to methyne proton distance of 6.6 A is determined indicating a conformation change leading to the formation of a second sphere enzyme-Co(II)-isobutyramide complex in which a hydroxyl or water ligand intervenes between the metal and the substrate analog.	methyne	69-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-64
164901-7	1975	This distance decreases to 6.9 A when NADH is bound, and a Co(II) to methyne proton distance of 6.6 A is determined indicating a conformation change leading to the formation of a second sphere enzyme-Co(II)-isobutyramide complex in which a hydroxyl or water ligand intervenes between the metal and the substrate analog.	methyne	69-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
164901-7	1975	This distance decreases to 6.9 A when NADH is bound, and a Co(II) to methyne proton distance of 6.6 A is determined indicating a conformation change leading to the formation of a second sphere enzyme-Co(II)-isobutyramide complex in which a hydroxyl or water ligand intervenes between the metal and the substrate analog.	Hydroxyl Radical	240-248	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-64
164901-7	1975	This distance decreases to 6.9 A when NADH is bound, and a Co(II) to methyne proton distance of 6.6 A is determined indicating a conformation change leading to the formation of a second sphere enzyme-Co(II)-isobutyramide complex in which a hydroxyl or water ligand intervenes between the metal and the substrate analog.	Hydroxyl Radical	240-248	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
164901-7	1975	This distance decreases to 6.9 A when NADH is bound, and a Co(II) to methyne proton distance of 6.6 A is determined indicating a conformation change leading to the formation of a second sphere enzyme-Co(II)-isobutyramide complex in which a hydroxyl or water ligand intervenes between the metal and the substrate analog.	Water	252-257	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-64
164901-7	1975	This distance decreases to 6.9 A when NADH is bound, and a Co(II) to methyne proton distance of 6.6 A is determined indicating a conformation change leading to the formation of a second sphere enzyme-Co(II)-isobutyramide complex in which a hydroxyl or water ligand intervenes between the metal and the substrate analog.	Water	252-257	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
164901-7	1975	This distance decreases to 6.9 A when NADH is bound, and a Co(II) to methyne proton distance of 6.6 A is determined indicating a conformation change leading to the formation of a second sphere enzyme-Co(II)-isobutyramide complex in which a hydroxyl or water ligand intervenes between the metal and the substrate analog.	Metals	288-293	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-64
164901-7	1975	This distance decreases to 6.9 A when NADH is bound, and a Co(II) to methyne proton distance of 6.6 A is determined indicating a conformation change leading to the formation of a second sphere enzyme-Co(II)-isobutyramide complex in which a hydroxyl or water ligand intervenes between the metal and the substrate analog.	Metals	288-293	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
164901-9	1975	The paramagnetic effects of Co(II), at the catalytic site, on the relaxation rates of the protons of ethanol at 100 and 220 MHz, indicate that this substrate bind at a site 12-14 A distant from the catalytic Co(II) but that this distancedecreases to 6.3 A in the abortive enzyme-NADH-ethanol complex.	Ethanol	101-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-34
164901-9	1975	The paramagnetic effects of Co(II), at the catalytic site, on the relaxation rates of the protons of ethanol at 100 and 220 MHz, indicate that this substrate bind at a site 12-14 A distant from the catalytic Co(II) but that this distancedecreases to 6.3 A in the abortive enzyme-NADH-ethanol complex.	Ethanol	101-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	208-214
164901-9	1975	The paramagnetic effects of Co(II), at the catalytic site, on the relaxation rates of the protons of ethanol at 100 and 220 MHz, indicate that this substrate bind at a site 12-14 A distant from the catalytic Co(II) but that this distancedecreases to 6.3 A in the abortive enzyme-NADH-ethanol complex.	NAD	279-283	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-34
164901-9	1975	The paramagnetic effects of Co(II), at the catalytic site, on the relaxation rates of the protons of ethanol at 100 and 220 MHz, indicate that this substrate bind at a site 12-14 A distant from the catalytic Co(II) but that this distancedecreases to 6.3 A in the abortive enzyme-NADH-ethanol complex.	Ethanol	284-291	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-34
164901-10	1975	The role of the catalytic Co(II) thus appears to be the activation of a hydroxyl or water ligand which polarizes the aldehyde carbonyl group by hydrogen bonding.	Hydroxyl Radical	72-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-32
164901-10	1975	The role of the catalytic Co(II) thus appears to be the activation of a hydroxyl or water ligand which polarizes the aldehyde carbonyl group by hydrogen bonding.	Water	84-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-32
164901-10	1975	The role of the catalytic Co(II) thus appears to be the activation of a hydroxyl or water ligand which polarizes the aldehyde carbonyl group by hydrogen bonding.	Aldehydes	117-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-32
164901-10	1975	The role of the catalytic Co(II) thus appears to be the activation of a hydroxyl or water ligand which polarizes the aldehyde carbonyl group by hydrogen bonding.	Hydrogen	144-152	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-32
164901-11	1975	The role of the structural Co(II), which is more distant from isobutyramide (9-11 A), may be that of a template for protein conformation changes.	isobutyramide	62-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-33
163245-1	1975	High resolution electron spin resonance spectra of the stepwise formation of CN- complexes of Co(II) and Cu(II) carbonic anhydrase show that both metal enzymes form successive 1:1 and 2:1 addition products with CN- at 112 K. The 1:1 complex with the Cu(II) enzyme has a rhombic ESR spectrum similar to the spectra of the 1:1 complexes of the Cu(II) enzyme with CH3COO-, OCN-, N3-, and SH-.	Copper	105-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-100
163245-1	1975	High resolution electron spin resonance spectra of the stepwise formation of CN- complexes of Co(II) and Cu(II) carbonic anhydrase show that both metal enzymes form successive 1:1 and 2:1 addition products with CN- at 112 K. The 1:1 complex with the Cu(II) enzyme has a rhombic ESR spectrum similar to the spectra of the 1:1 complexes of the Cu(II) enzyme with CH3COO-, OCN-, N3-, and SH-.	Metals	146-151	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-100
163245-1	1975	High resolution electron spin resonance spectra of the stepwise formation of CN- complexes of Co(II) and Cu(II) carbonic anhydrase show that both metal enzymes form successive 1:1 and 2:1 addition products with CN- at 112 K. The 1:1 complex with the Cu(II) enzyme has a rhombic ESR spectrum similar to the spectra of the 1:1 complexes of the Cu(II) enzyme with CH3COO-, OCN-, N3-, and SH-.	cu(ii)	105-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-100
163245-1	1975	High resolution electron spin resonance spectra of the stepwise formation of CN- complexes of Co(II) and Cu(II) carbonic anhydrase show that both metal enzymes form successive 1:1 and 2:1 addition products with CN- at 112 K. The 1:1 complex with the Cu(II) enzyme has a rhombic ESR spectrum similar to the spectra of the 1:1 complexes of the Cu(II) enzyme with CH3COO-, OCN-, N3-, and SH-.	cu(ii)	250-256	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-100
163245-1	1975	High resolution electron spin resonance spectra of the stepwise formation of CN- complexes of Co(II) and Cu(II) carbonic anhydrase show that both metal enzymes form successive 1:1 and 2:1 addition products with CN- at 112 K. The 1:1 complex with the Cu(II) enzyme has a rhombic ESR spectrum similar to the spectra of the 1:1 complexes of the Cu(II) enzyme with CH3COO-, OCN-, N3-, and SH-.	ocn	370-373	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-100
163245-5	1975	Under the same conditions a structurally analogous dicyanide complex of the co(II) enzyme forms with the appearance of and axial ESR signal typical of low spin Co(II).	Hydroxysanguinarine	51-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-82
163245-5	1975	Under the same conditions a structurally analogous dicyanide complex of the co(II) enzyme forms with the appearance of and axial ESR signal typical of low spin Co(II).	Hydroxysanguinarine	51-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	160-166
163245-7	1975	The dicyanide complexes of the Co(II) and Cu(II) enzymes form completely only in frozen solutions and analysis of the ESR spectra show them to have a 5-coordinate square pyrimidal geometry.	Hydroxysanguinarine	4-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-37
18961581-1	1974	Indium can be separated from Zn, Pb(II), Ga, Ca, Be, Mg, Ti(IV), Mn(II), Fe(III), Al, U(VI), Na, Ni(II) and Co(II) by selective elution with 0.50M hydrochloric acid in 30% aqueous acetone from a column of AG50W-X8 cation-exchange resin, all the other elements being retained by the column.	Indium	0-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-114
241628-2	1975	In static tests at pH 4.5, chelates of Mn(II), Fe(II) and Co(II) photodegraded to give 14CO2 and CH2O.	Manganese(2+)	39-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-64
241628-2	1975	In static tests at pH 4.5, chelates of Mn(II), Fe(II) and Co(II) photodegraded to give 14CO2 and CH2O.	14co2	87-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-64
241628-2	1975	In static tests at pH 4.5, chelates of Mn(II), Fe(II) and Co(II) photodegraded to give 14CO2 and CH2O.	Formaldehyde	97-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-64
33741381-9	2021	However, both Asp-X3-CH3 and Asp-X3 exerted a similar effect on the level of COX-2 in gastric cancer cells, causing as much as 90% and 95% reduction in COX-2 expression, respectively.	Aspartic Acid	14-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-82
4420261-0	1974	[Determination of Co(II) in pharmaceutical preparations by means of 1-thiocarbamoyl-3-methyl-5-pyrazolone].	1-thiocarbamoyl-3-methyl-5-pyrazolone	68-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-24
5055285-0	1972	Spectrophotometric determination of Co(II) by means of dithiosemicarbazone of  , -dioxobutane- ,  -dicarboxylic acid diethyl ester.	dithiosemicarbazone	55-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-41
5055285-0	1972	Spectrophotometric determination of Co(II) by means of dithiosemicarbazone of  , -dioxobutane- ,  -dicarboxylic acid diethyl ester.	, -dioxobutane- ,  -dicarboxylic acid diethyl ester	79-130	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-41
18960996-5	1971	Among the platinum group metals, Pd(II), Ir(IV) and Pt(IV) are adsorbed from the mixed solvents and may be separated from large quantities of base metals such as Fe(III), Co(II), Ni and Cu(II).	Polydioxanone	33-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	171-177
18960973-2	1971	Mg, Ca, Cu(II), Zn and Co(II) accompany Mn(II).	Manganese(2+)	40-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-29
18960717-1	1970	The acid dissociation constants (K(a)) of di-p-fluoro-, di-p-chloro-, di-p-bromo-, di-p-iodo-and di-m-trifluoromethylphenylthiocarbazones and the equilibrium formation constants (K(f(1))) of their 1:1 complexes with Co(II), Ni and Zn have been determined at 25 degrees in 50% v v aqueous dioxan at 0.10 M ionic strength.	di-p-fluoro-, di-p-chloro-, di-p-bromo-, di-p-iodo-and di-m-trifluoromethylphenylthiocarbazones	42-137	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	216-222
18960505-1	1969	Reactions between dithizonates and oxinates of Ag, Tl(I), Cu(II), Zn, Cd, Hg(II), Pb, Co(II), Ni, Pd, In, Ga and Bi in chloroform have been studied spectrophotometrically.	dithizonates	18-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-92
18960505-1	1969	Reactions between dithizonates and oxinates of Ag, Tl(I), Cu(II), Zn, Cd, Hg(II), Pb, Co(II), Ni, Pd, In, Ga and Bi in chloroform have been studied spectrophotometrically.	Bismuth	113-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-92
18960208-3	1967	Th, Bi(III), Ba, Sr, Ca, Mg, Mn(II), Pb(II), Cu(II), Cd, Ni, Co(II) and Zn have been successfully titrated.	Thorium	0-2	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-67
18960049-1	1966	The acid dissociation constants of 4-(2"-thiazolylazo)-resorcinol (TAR) and the formation constants of the metal complexes formed by this reagent with Cu(II), Ni(II), Co(II), Zn(II) and Mn(II) have been determined potentiometrically at 25 degrees in 50% v/v mixtures of dioxane and water.	4-(2-thiazolylazo)resorcinol	35-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	167-173
33910746-2	2021	The presence of active sites such as hydroxyl, carbonyl, thioethers, and amines, gave the membranes high adsorption capacities for the metal ions Au (III), Co (II), and Fe (III), as well as the cationic organic dye methylene blue (MB).	Hydroxyl Radical	37-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	156-163
33910746-2	2021	The presence of active sites such as hydroxyl, carbonyl, thioethers, and amines, gave the membranes high adsorption capacities for the metal ions Au (III), Co (II), and Fe (III), as well as the cationic organic dye methylene blue (MB).	Sulfides	57-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	156-163
33910746-2	2021	The presence of active sites such as hydroxyl, carbonyl, thioethers, and amines, gave the membranes high adsorption capacities for the metal ions Au (III), Co (II), and Fe (III), as well as the cationic organic dye methylene blue (MB).	Amines	73-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	156-163
33910746-2	2021	The presence of active sites such as hydroxyl, carbonyl, thioethers, and amines, gave the membranes high adsorption capacities for the metal ions Au (III), Co (II), and Fe (III), as well as the cationic organic dye methylene blue (MB).	Metals	135-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	156-163
33910746-2	2021	The presence of active sites such as hydroxyl, carbonyl, thioethers, and amines, gave the membranes high adsorption capacities for the metal ions Au (III), Co (II), and Fe (III), as well as the cationic organic dye methylene blue (MB).	Methylene Blue	215-229	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	156-163
33910746-2	2021	The presence of active sites such as hydroxyl, carbonyl, thioethers, and amines, gave the membranes high adsorption capacities for the metal ions Au (III), Co (II), and Fe (III), as well as the cationic organic dye methylene blue (MB).	Methylene Blue	231-233	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	156-163
18961390-4	1973	Co(II), Mn(II), Mg, Ca, Ti(IV), Al, Zr, Th and La are quantitatively retained by the column.	Aluminum	32-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
4320976-8	1970	The similarity of the esr spectra of spin-labeled Zn(II) and Co(II) carbonic anhydrases suggests that the conformation at the active center is similar in the two metal derivatives.	Metals	162-167	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-67
5263759-1	1970	A 220-MHz proton nuclear magnetic resonance study of the binding of Ni(II) and Co(II) acetylacetonates to retinyl-N-methyl Schiff"s bases is presented.	retinyl-n-methyl schiff"s bases	106-137	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-85
18960293-3	1968	The determination is possible in the presence of Ni, Cr(VI), W(VI), Mn(II), Co(II), Cu(II) or Th, with an accuracy of 2% in the range 10(-5)-10(-3)M.	Thorium	0-2	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-82
33618090-2	2021	Thecomplexationof Co(II) ions was carried out by using dithizone solution as complexing agent at pH5.The key variables affecting microextraction steps were optimized by response surface methodology (RSM) based on central composite design.	Dithizone	55-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-24
33858095-0	2021	Efficient removal of Co(II) and Sr(II) from aqueous solution using polyvinyl alcohol/graphene oxide/MnO2 composite as a novel adsorbent.	Polyvinyl Alcohol	67-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-38
33858095-0	2021	Efficient removal of Co(II) and Sr(II) from aqueous solution using polyvinyl alcohol/graphene oxide/MnO2 composite as a novel adsorbent.	graphene oxide	85-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-38
33858095-0	2021	Efficient removal of Co(II) and Sr(II) from aqueous solution using polyvinyl alcohol/graphene oxide/MnO2 composite as a novel adsorbent.	manganese dioxide	100-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-38
33741381-9	2021	However, both Asp-X3-CH3 and Asp-X3 exerted a similar effect on the level of COX-2 in gastric cancer cells, causing as much as 90% and 95% reduction in COX-2 expression, respectively.	Aspartic Acid	14-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-157
33741331-2	2021	A platinum(IV) conjugate ketoplatin deriving from FDA-approved drugs cisplatin and ketoprofen was designed and prepared to enhance antitumor activity and suppress EMT in TNBC via positive impact on inflammatory microenvironment by modulating COX-2 signal.	Platinum	2-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	242-247
33741331-2	2021	A platinum(IV) conjugate ketoplatin deriving from FDA-approved drugs cisplatin and ketoprofen was designed and prepared to enhance antitumor activity and suppress EMT in TNBC via positive impact on inflammatory microenvironment by modulating COX-2 signal.	ketoplatin	25-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	242-247
33741331-2	2021	A platinum(IV) conjugate ketoplatin deriving from FDA-approved drugs cisplatin and ketoprofen was designed and prepared to enhance antitumor activity and suppress EMT in TNBC via positive impact on inflammatory microenvironment by modulating COX-2 signal.	Ketoprofen	83-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	242-247
33737009-5	2021	Computational docking analysis together with quantum chemistry calculation shows that galangin can bind inside the peroxidase active sites of COX-1 and COX-2 in a similar manner as quercetin, but it has little ability to effectively donate its electrons, thereby blocking the effect of the reducing cosubstrates like quercetin.	galangin	86-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-157
33872924-2	2021	8a-p have been assessed for their inhibitory activity against COX-1/COX-2 activity.	8a-p	0-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-73
33872924-3	2021	Compounds 8h, 8n, and 8p were found to be potent and selective COX-2 inhibitors (IC50 = 1.03-1.71 muM) relative to celecoxib (IC50 = 0.88 muM).	8h	10-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-68
33872924-3	2021	Compounds 8h, 8n, and 8p were found to be potent and selective COX-2 inhibitors (IC50 = 1.03-1.71 muM) relative to celecoxib (IC50 = 0.88 muM).	8p	22-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-68
33872924-9	2021	Anti-proliferative and wild-type EGFR inhibitory assays displayed similar results to selective COX-2 inhibition where compounds 8h, 8n, and 8p had a superior inhibition than other tested ones.	8p	140-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-100
33169272-9	2021	Without inflammatory pre-stimulation, COX-2 expression was increased by compression and zoledronate.	Zoledronic Acid	88-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-43
33169272-13	2021	Further addition of zoledronate to pre-stimulated cells additionally strengthened the compression-induced upregulation of COX-2 and IL-6 expression as well as protein secretion compared to all other groups.	Zoledronic Acid	20-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-127
33275302-0	2021	Crosstalk between the COX2-PGE2-EP4 signaling pathway and primary cilia in osteoblasts after mechanical stimulation.	Dinoprostone	27-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-26
33275302-3	2021	We hypothesized that LMHFV stimulates osteoblast (OB) differentiation by activating the COX2-PGE2-EP pathway in a manner dependent on primary cilia and that primary cilia are also affected by the PGE2 pathway.	lmhfv	21-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-92
33275302-3	2021	We hypothesized that LMHFV stimulates osteoblast (OB) differentiation by activating the COX2-PGE2-EP pathway in a manner dependent on primary cilia and that primary cilia are also affected by the PGE2 pathway.	Dinoprostone	93-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-92
33275302-4	2021	In this study, through western blot analysis, RNA interference, enzyme-linked immunosorbent assay, real-time quantitative polymerase chain reaction, and cytochemical staining, we observed that COX2, mPGES-1, and PGE2 levels were markedly elevated in cells treated with LMHFV and were greatly decreased in LMHFV-treated cells following IFT88 silencing.	lmhfv	269-274	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	193-197
33275302-9	2021	In addition, COX2 or EP4 antagonism disrupted LMHFV-induced osteogenesis.	lmhfv	46-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-17
33275302-10	2021	These results demonstrate the integration of and crosstalk between primary cilia and the COX2-PGE2-EP4 signaling pathway under mechanical stimulation.	Dinoprostone	94-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-93
34037636-1	2021	Soaking crystals of an AuI72CdII40NaI4 cage-of-cage in aqueous Co(NO3)2 afforded an analogous AuI72CoII44 cage-of-cage, accompanied by the exchange of NaI and CdII by CoII with retention of the single crystallinity.	aui72cdii40nai4	23-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-103
34037636-1	2021	Soaking crystals of an AuI72CdII40NaI4 cage-of-cage in aqueous Co(NO3)2 afforded an analogous AuI72CoII44 cage-of-cage, accompanied by the exchange of NaI and CdII by CoII with retention of the single crystallinity.	cobaltous nitrate	63-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-103
34037636-1	2021	Soaking crystals of an AuI72CdII40NaI4 cage-of-cage in aqueous Co(NO3)2 afforded an analogous AuI72CoII44 cage-of-cage, accompanied by the exchange of NaI and CdII by CoII with retention of the single crystallinity.	nai	34-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-103
34031121-6	2021	Our findings establish the COX-2/PGE2/EP2-4 axis as an independent immune checkpoint and a readily translatable strategy to rapidly switch the tumor inflammatory profile from cold to hot.	Dinoprostone	33-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-32
34031130-4	2021	The PG synthesis and secretion are regulated by substrate availability of arachidonic acid and by the COX-2 enzyme, and the expression of this protein is regulated at multiple levels, both transcriptionally and post-transcriptionally.	Prostaglandins	4-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-107
34021476-8	2021	Gene expression study of Cox-2 showed a drastically reduced expression with CsA treatment indicating Cox-2 involvement in the calcineurin-NFAT pathway.	Cyclosporine	76-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-30
34021476-8	2021	Gene expression study of Cox-2 showed a drastically reduced expression with CsA treatment indicating Cox-2 involvement in the calcineurin-NFAT pathway.	Cyclosporine	76-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-106
33865053-0	2021	Design, synthesis, biological evaluation, and computational studies of novel thiazolo-pyrazole hybrids as promising selective COX-2 inhibitors: Implementation of apoptotic genes expression for ulcerogenic liability assessment.	thiazolo-pyrazole	77-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-131
33865053-1	2021	A novel series of thiazolo-pyrazole hybrids has been prepared and assessed for their in vitro COX-1/COX-2 inhibitory activity.	thiazolo-pyrazole	18-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-105
33497983-6	2021	Quenching reactions and EPR studies revealed the coexistence of sulfate radical (SO4 -), hydroxyl radical ( OH), and singlet oxygen (1O2), which was attributed to the potential in-situ recycling of cobalt and copper species (Co(III) Co(II), Cu(II) Cu(I))).	Cobalt	198-204	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	233-239
33497983-6	2021	Quenching reactions and EPR studies revealed the coexistence of sulfate radical (SO4 -), hydroxyl radical ( OH), and singlet oxygen (1O2), which was attributed to the potential in-situ recycling of cobalt and copper species (Co(III) Co(II), Cu(II) Cu(I))).	Copper	209-215	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	233-239
33988372-5	2021	When NiCo2O4 is supported on NCNT via the CoII ion, the rate-determining step of ORR catalyzed by CoIII and NiIII sites is altered.	nico2o4	5-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-46
34029712-3	2021	Symptoms due to increased baseline and/or episodic release of PGD2 can be prevented with aspirin, an inhibitor of cyclooxygenase (COX)1 and COX2.	Prostaglandin D2	62-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-144
34029712-3	2021	Symptoms due to increased baseline and/or episodic release of PGD2 can be prevented with aspirin, an inhibitor of cyclooxygenase (COX)1 and COX2.	Aspirin	89-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-144
34014968-4	2021	The total mean carbon sequestered at the national level, considering the cumulative number of natural resource based activities, for the year 2017-18 was estimated to be 102 MtCO2.	Carbon	15-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	174-179
34014968-5	2021	The annual mean carbon sequestration is projected to increase to about 132 MtCO2 by 2020 and 249 MtCO2 by 2030.	Carbon	16-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
34014968-5	2021	The annual mean carbon sequestration is projected to increase to about 132 MtCO2 by 2020 and 249 MtCO2 by 2030.	Carbon	16-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
34014968-7	2021	The cumulative carbon sink created by drought proofing activities is projected to be 56 MtCO2 in 2020, 281 MtCO2 in 2025 and 561 MtCO2 in 2030.	Carbon	15-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-93
34014968-7	2021	The cumulative carbon sink created by drought proofing activities is projected to be 56 MtCO2 in 2020, 281 MtCO2 in 2025 and 561 MtCO2 in 2030.	Carbon	15-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-112
34014968-7	2021	The cumulative carbon sink created by drought proofing activities is projected to be 56 MtCO2 in 2020, 281 MtCO2 in 2025 and 561 MtCO2 in 2030.	Carbon	15-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-112
33737009-7	2021	The results of the present study demonstrate that galangin is a novel naturally-occurring inhibitor of COX-1 and COX-2, acting by blocking the function of the reducing cosubstrates at the peroxidase sites.	galangin	50-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-118
33980833-5	2021	In this study, we determine that the magnetic anisotropy of a Co(II) complex can be effectively controlled by the slight rotation of coordinating water ligands, which is achieved by a two-step structural phase transition.	Water	146-151	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-68
33991632-0	2021	Green synthesis of therapeutically active 1,3,4-oxadiazoles as antioxidants, selective COX-2 inhibitors and their in silico studies.	1,3,4-oxadiazole	42-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-92
33991632-4	2021	The compounds 8i, 8l, 8q, 8r, 8s and 8t emerged as most potent and selective COX-2 inhibitors in contrast with Mefenamic acid.	3-azido-2,7-naphthalene disulfonate	33-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-82
33978902-0	2021	Inhibition of gammaH2AX, COX-2 and regulation of antioxidant enzymes in MPP+-exposed SH-SY5Y cells pre-treated with rutin.	Rutin	116-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-30
33978902-7	2021	It was also observed that rutin significantly reduced protein expression levels of gammaH2AX and COX-2 in SH-SY5Y cells treated with MPP+.	Rutin	26-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
33955333-0	2021	Structure, DFT studies and evaluation of catechol oxidase (CO) mimic activity of mononuclear Co(II) complexes derived from aminoalcohols: an experimental and theoretical approach.	Amino Alcohols	123-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-99
33975019-3	2021	The treatment with ASA caused an increase in the gene expression of COX2 and ABCB1 in both MDR cell lines, and a decrease in the expression of ALOX5 in the FEPS cells.	Aspirin	19-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-72
33964802-3	2021	In order to study the selectivity of NO-IND-TZDs for COX isoenzymes (COX-1 and COX-2) a molecular docking study was performed using AutoDock 4.2.6 software.	Indomethacin	40-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-84
33964802-3	2021	In order to study the selectivity of NO-IND-TZDs for COX isoenzymes (COX-1 and COX-2) a molecular docking study was performed using AutoDock 4.2.6 software.	tzds	44-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-84
33964802-4	2021	Based on docking results, COX-2 inhibitors were designed and 6o appears as the most selective derivative which showed an improved selective index compared with indomethacin (IND) and diclofenac (DCF), used as reference drugs.	Indomethacin	160-172	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-31
33964802-4	2021	Based on docking results, COX-2 inhibitors were designed and 6o appears as the most selective derivative which showed an improved selective index compared with indomethacin (IND) and diclofenac (DCF), used as reference drugs.	Indomethacin	174-177	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-31
33964802-4	2021	Based on docking results, COX-2 inhibitors were designed and 6o appears as the most selective derivative which showed an improved selective index compared with indomethacin (IND) and diclofenac (DCF), used as reference drugs.	Diclofenac	183-193	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-31
33964802-4	2021	Based on docking results, COX-2 inhibitors were designed and 6o appears as the most selective derivative which showed an improved selective index compared with indomethacin (IND) and diclofenac (DCF), used as reference drugs.	Diclofenac	195-198	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-31
34025440-4	2021	Furthermore, in RPE cells exposed to HG we observed a significant increase of iNOS, COX-2, and IL-1beta expression, that was reverted by DMF treatment.	Dimethyl Fumarate	137-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-89
34026596-8	2021	Similar patterns of beta-elemene-modulated cyclinD1, c-Myc, COX2, MMP2, MMP9, VEGF, PTEN and Notch1 expression were detected in NSCLC cells.	beta-elemene	20-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-64
33957012-7	2021	The literature review suggested that phytosteroids exhibit antiinflammatory action via different modes through transrepression or selective COX-2 enzymes.	Phytosterols	37-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-145
33955172-0	2021	Molecular docking-guided synthesis of NSAID-glucosamine bioconjugates and their evaluation as COX-1/COX-2 inhibitors with potentially reduced gastric toxicity.	Glucosamine	44-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-105
33877803-6	2021	Additionally, Ramelteon prevented an LPS-induced increase in the expressions of iNOS, COX-2, NO, and PGE2.	ramelteon	14-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-91
33955172-4	2021	We report herein the conjugation of commonly prescribed NSAIDs to glucosamine hydrochloride and the use of molecular docking to show that addition of the carbohydrate moiety to the parent NSAID can enhance binding in the active site of COX-2.	Glucosamine hydrochloride	66-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	236-241
33955172-4	2021	We report herein the conjugation of commonly prescribed NSAIDs to glucosamine hydrochloride and the use of molecular docking to show that addition of the carbohydrate moiety to the parent NSAID can enhance binding in the active site of COX-2.	Carbohydrates	154-166	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	236-241
33955172-5	2021	In a preliminary, in vitro screening assay, the diclofenac-glucosamine bioconjugate exhibited 10-fold greater activity towards COX-2, making it an ideal candidate for future in vivo studies.	diclofenac-glucosamine	48-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	127-132
33412472-7	2021	Such favorable effect was partially ascribed to the specific ligand structure of six coordination structure between phosphate and cobalt, which facilitated electron transfer in the CoIII/CoII reduction.	Phosphates	116-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	181-185
33955172-6	2021	Furthermore, in an intriguing result, we observed that the mefenamic-acid-glucosamine bioconjugate displayed enhanced activity towards COX-1 rather than COX-2.	Mefenamic Acid	59-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	153-158
33412472-7	2021	Such favorable effect was partially ascribed to the specific ligand structure of six coordination structure between phosphate and cobalt, which facilitated electron transfer in the CoIII/CoII reduction.	Cobalt	130-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	181-185
33412472-8	2021	In addition, it was dependent upon the aqueous phosphate levels, and low level (< 0.5 mM) was insufficient to drive the CoIII/CoII cycle, whereas the higher level (> 15 mM) showed negative effect since the excessive phosphate could quench SO4 - and OH.	Phosphates	47-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-124
33955172-6	2021	Furthermore, in an intriguing result, we observed that the mefenamic-acid-glucosamine bioconjugate displayed enhanced activity towards COX-1 rather than COX-2.	Glucosamine	74-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	153-158
33904544-7	2021	The UV-vis absorbance of CoII further corroborates TX-100-assisted water pool formation within TBAC-DA via the appearance of the band that is assigned to the response of the probe in water.	Octoxynol	51-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-29
33904544-7	2021	The UV-vis absorbance of CoII further corroborates TX-100-assisted water pool formation within TBAC-DA via the appearance of the band that is assigned to the response of the probe in water.	Water	67-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-29
33904544-7	2021	The UV-vis absorbance of CoII further corroborates TX-100-assisted water pool formation within TBAC-DA via the appearance of the band that is assigned to the response of the probe in water.	tbac-da	95-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-29
33904544-7	2021	The UV-vis absorbance of CoII further corroborates TX-100-assisted water pool formation within TBAC-DA via the appearance of the band that is assigned to the response of the probe in water.	Water	183-188	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-29
33882668-0	2021	Are Free Radicals the Primary Reactive Species in Co(II)-Mediated Activation of Peroxymonosulfate?	peroxymonosulfate	80-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-56
33882668-1	2021	New Evidence for the Role of the Co(II)-Peroxymonosulfate Complex.	peroxymonosulfate	40-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-39
33882668-3	2021	Among all catalysts examined, Co(II) exhibits the highest reactivity for the activation of PMS, following the conventional Fenton-like mechanism, in which free radicals (i.e., sulfate radicals and hydroxyl radicals) are reckoned as the reactive species.	Free Radicals	155-168	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-36
33882668-3	2021	Among all catalysts examined, Co(II) exhibits the highest reactivity for the activation of PMS, following the conventional Fenton-like mechanism, in which free radicals (i.e., sulfate radicals and hydroxyl radicals) are reckoned as the reactive species.	sulfate radical	176-192	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-36
33949535-0	2021	Insertion of single-ion magnets based on mononuclear Co(II) complexes into ferromagnetic oxalate-based networks.	ferromagnetic oxalate	75-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-59
33882668-3	2021	Among all catalysts examined, Co(II) exhibits the highest reactivity for the activation of PMS, following the conventional Fenton-like mechanism, in which free radicals (i.e., sulfate radicals and hydroxyl radicals) are reckoned as the reactive species.	Hydroxyl Radical	197-214	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-36
33882668-4	2021	Herein, we report that the primary reactive species (PRS) is proposed to be a Co(II)-PMS complex (Co(II)-OOSO3-), while free radicals and Co(III) species act as the secondary reactive species (SRS) that play a minor role in the Co(II)/PMS process.	peroxymonosulfate	85-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-84
33882668-4	2021	Herein, we report that the primary reactive species (PRS) is proposed to be a Co(II)-PMS complex (Co(II)-OOSO3-), while free radicals and Co(III) species act as the secondary reactive species (SRS) that play a minor role in the Co(II)/PMS process.	peroxymonosulfate	85-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-110
33882668-4	2021	Herein, we report that the primary reactive species (PRS) is proposed to be a Co(II)-PMS complex (Co(II)-OOSO3-), while free radicals and Co(III) species act as the secondary reactive species (SRS) that play a minor role in the Co(II)/PMS process.	peroxymonosulfate	85-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-104
33882668-4	2021	Herein, we report that the primary reactive species (PRS) is proposed to be a Co(II)-PMS complex (Co(II)-OOSO3-), while free radicals and Co(III) species act as the secondary reactive species (SRS) that play a minor role in the Co(II)/PMS process.	peroxymonosulfate	235-238	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-84
33882668-5	2021	This Co(II)-OOSO3- exhibits several intriguing properties including ability to conduct both one-electron-transfer and oxygen-atom-transfer reactions with selected molecules, both nucleophilic and electrophilic in nature, and strongly pH-dependent reactivity.	Oxygen	118-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	5-11
33109362-3	2021	Upon PMS activation by nZVI, PMS produces more highly reactive oxygen species (ROS) in both aqueous solution and soil compared to other compounds (PMS/Co(II)), as determined by electron paramagnetic resonance spectroscopy.	peroxymonosulfate	5-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-157
34035660-8	2021	Results: In IL-1beta-primed cells, preincubation with Vanillin reduced IL-6, IL-8, COX-2, and iNOS expression and NO release, compared to IL-1beta-primed cells.	vanillin	54-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
34035660-10	2021	Furthermore, in presence of mechanical injury, the Vanillin preincubation, wound closure may be reducing the expression and release of IL-6 and TNF-alpha and upregulation of COX-2 and IL-8.	vanillin	51-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	174-179
33662521-3	2021	In this study, we explored the influence of hCOX-2 transgenic [TG] to high fat with ethanol-induced metabolic disorder and liver injury using a mouse animal model.	Ethanol	84-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-50
33662521-8	2021	Hepatic hCOX-2 overexpression enhanced AKT insulin signaling and increased fatty acid synthesis in both RCD and HF+Eth diet groups.	Fatty Acids	75-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	8-14
33662521-8	2021	Hepatic hCOX-2 overexpression enhanced AKT insulin signaling and increased fatty acid synthesis in both RCD and HF+Eth diet groups.	Ethionamide	115-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	8-14
33662521-9	2021	The anti-lipogenic effect of hCOX-2 TG in the HF+Eth diet animals was mediated by increasing lipid disposal through enhanced beta-oxidation via elevations in the expression of PPARalpha and PPARgamma, and increased hepatic autophagy as assessed by the ratio of autophagy markers LC3 II/I in hepatic tissue.	Ethionamide	49-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-35
33662521-10	2021	Various protein acetylation pathway components, including HAT, HDAC1, SIRT1, and SNAIL1, were modulated in hCOX-2 TG mice in either RCD or HF+Eth diet.	Ethionamide	142-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-113
33403814-1	2021	We report the synthesis of a novel metal-organic capsule constructed from six pyrogallol[4]arene macrocycles, which are switched together by 16 Fe(III) and 16 Co(II) ions.	Metals	35-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	159-165
33403814-1	2021	We report the synthesis of a novel metal-organic capsule constructed from six pyrogallol[4]arene macrocycles, which are switched together by 16 Fe(III) and 16 Co(II) ions.	pyrogallol(4)arene	78-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	159-165
33635600-2	2021	In this work, we developed a conductive metallophthalocyanine-based NiPc-CoTAA framework connected with the Co(II) tetraaza[14]annulene linkage.	metallophthalocyanine	40-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-114
33635600-2	2021	In this work, we developed a conductive metallophthalocyanine-based NiPc-CoTAA framework connected with the Co(II) tetraaza[14]annulene linkage.	2-(2-thienyl)allylamine	68-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-114
33470478-7	2021	Prostaglandins E2 (PGE2), secreted by hUC-MSCs, is one of the crucial immunomodulatory factors and could be inhibited in the presence of COX2 inhibitor, NS-398.	Dinoprostone	0-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-141
33470478-7	2021	Prostaglandins E2 (PGE2), secreted by hUC-MSCs, is one of the crucial immunomodulatory factors and could be inhibited in the presence of COX2 inhibitor, NS-398.	Dinoprostone	19-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-141
33470478-7	2021	Prostaglandins E2 (PGE2), secreted by hUC-MSCs, is one of the crucial immunomodulatory factors and could be inhibited in the presence of COX2 inhibitor, NS-398.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	153-159	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-141
33995374-4	2021	Here, we showed that HP-PRRSV infection increased PGE2 production in microglia via COX-2 up-regulation depending on the activation of MEK1-ERK1/2-C/EBPbeta signaling pathways.	Dinoprostone	50-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
33609598-12	2021	In addition, treatment with AuNPs significantly restored iNOS and COX-2 levels in Abeta-treated hNSCs.	aunps	28-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-71
33930279-6	2021	In contrast, TNF-alpha was inhibited only by SAC, and COX2 only by colchicine.	Colchicine	67-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-58
33946200-1	2021	In this article, the application of a polymer film containing the ionic liquid Cyphos IL 101 for the simultaneous recovery of precious and heavy metal ions ((Ni(II), Zn(II), Co(II), Cu(II), Sn(II), Pb(II), Ag(I), Pd(II), and Au(III)) from waste electrical and electronic equipment (WEEE) is described.	Polymers	38-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	174-180
33995374-0	2021	NSP2 Is Important for Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus to Trigger High Fever-Related COX-2-PGE2 Pathway in Pigs.	Dinoprostone	128-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-127
33722629-0	2021	Phytoprostanes and phytofurans modulate COX-2-linked inflammation markers in LPS-stimulated THP-1 monocytes by lipidomics workflow.	phytoprostanes	0-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
33722629-0	2021	Phytoprostanes and phytofurans modulate COX-2-linked inflammation markers in LPS-stimulated THP-1 monocytes by lipidomics workflow.	phytofurans	19-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
33636560-9	2021	Molecular analyses indicated that the protection mediated by L-Ctl against LPS-evoked sepsis targeted the TLR4/ERK/JNK/p38-MAPK pathway, regulating NFkB p65, NFkB p52 and COX2 expression and repressing the mRNA expression levels of the LPS-induced proinflammatory factors IL-1beta, IL-6, TNF-alpha and NOS2.	l-ctl	61-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	171-175
33632872-3	2021	Searching for molecular mechanisms leading to such differences, we found that VPA treatment dysregulated choline metabolism and triggered a stronger ER stress in pancreatic cancer cells than TSA, up-regulating CHOP, and activated COX2, thus promoting the release of prostaglandin (PG) E2.	Valproic Acid	78-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	230-234
33914261-0	2021	In Vitro Anticancer Activity of Novel Co(II) and Ni(II) Complexes of Non-steroidal Anti-inflammatory Drug Niflumic Acid Against Human Breast Adenocarcinoma MCF-7 Cells.	Niflumic Acid	106-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-44
33914261-1	2021	Herein, we report the synthesis, characterization and anticancer activity of six novel complexes of non-steroidal anti-inflammatory drug niflumic acid with Co(II) and Ni(II).	Niflumic Acid	137-150	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	156-162
33925793-5	2021	5-MTP inhibits cancer cell COX-2 expression and thereby reduces COX-2-mediated cell proliferation and migration.	5-methoxytryptophan	0-5	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-32
33947051-1	2021	A biomaterial based on poly(vinyl alcohol) reticulated with tricarboxi-cellulose obtained by TEMPO oxidation (OxC25) was used as a new biosorbent for Co(II) ions retention from aqueous solutions.	Polyvinyl Alcohol	23-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	150-156
33947051-1	2021	A biomaterial based on poly(vinyl alcohol) reticulated with tricarboxi-cellulose obtained by TEMPO oxidation (OxC25) was used as a new biosorbent for Co(II) ions retention from aqueous solutions.	tricarboxi-cellulose	60-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	150-156
33901329-0	2021	Rotaxane CoII Complexes as Field-Induced Single-Ion Magnets.	Rotaxanes	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	9-13
33901329-5	2021	The predictable magnetic behavior of the rotaxane Co II complexes demonstrates that interlocked ligands offer a new strategy to design metal complexes with interesting functionality.	Metals	135-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-55
34052736-4	2021	The same analogs were further investigated for their in vitro COX-1 and COX-2 inhibitory activity, where fifteen analogs demonstrated recognizable COX-2 inhibitory potential (IC50 values range 0.04 - 0.1 microM), when correlated with celecoxib (IC50 0.05 microM), together with appreciable selectivity indices.	Celecoxib	234-243	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-152
34052736-7	2021	Docking of compounds 5a, 14b, 17, 19c, 19e and 21b with the active sites of XO and COX-2 isozymes demonstrated superior binding profile compared with the reported ligands (febuxostat and celecoxib, respectively).	Febuxostat	172-182	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
34052736-7	2021	Docking of compounds 5a, 14b, 17, 19c, 19e and 21b with the active sites of XO and COX-2 isozymes demonstrated superior binding profile compared with the reported ligands (febuxostat and celecoxib, respectively).	Celecoxib	187-196	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
33925793-5	2021	5-MTP inhibits cancer cell COX-2 expression and thereby reduces COX-2-mediated cell proliferation and migration.	5-methoxytryptophan	0-5	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-69
33444716-14	2021	COX2 inhibitor (NS-398), and aspirin, a drug that prevents the development of CVD by targeting COX2, exhibited similar effects to NXT in the treatment of OGD/R EA.hy926 cells.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	16-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-4
33755727-6	2021	It revealed a tuning effect of different metal ions on the anti-cancer activities with that for Mn(II) and Zn(II) being much higher than that for Co(II) and Ni(II) in this system.	Metals	41-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	146-152
33932662-4	2021	Outdoor exposure exhibited different effects on adsorption property of MPs for metal ions, where adsorption capacities of PE and PS MPs for Co(II) were increased with aging degrees, while few change occurred on different aged PP MPs.	Metals	79-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-146
33932662-4	2021	Outdoor exposure exhibited different effects on adsorption property of MPs for metal ions, where adsorption capacities of PE and PS MPs for Co(II) were increased with aging degrees, while few change occurred on different aged PP MPs.	Polyethylene	122-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-146
33932662-4	2021	Outdoor exposure exhibited different effects on adsorption property of MPs for metal ions, where adsorption capacities of PE and PS MPs for Co(II) were increased with aging degrees, while few change occurred on different aged PP MPs.	Polystyrenes	129-131	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-146
33290612-2	2021	In this context, we report new artificial peptide ligands that fold into chiral helicates in the presence of labile metal ions such as Fe(II) and Co(II).	Metals	116-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	146-152
33529486-3	2021	A detailed analysis of the electronic structure of Cobalt dimers of the general formula Co2Cl2Ln  (L = NH3 and PH3)  demonstrates that electron transfer is triggered by asymetric coordination of amine and phosphine to stabilize a mixed-valence Co(II)-Co(0) dimer.	Cobalt	51-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	244-250
33529486-3	2021	A detailed analysis of the electronic structure of Cobalt dimers of the general formula Co2Cl2Ln  (L = NH3 and PH3)  demonstrates that electron transfer is triggered by asymetric coordination of amine and phosphine to stabilize a mixed-valence Co(II)-Co(0) dimer.	co2cl2ln	88-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	244-250
33529486-3	2021	A detailed analysis of the electronic structure of Cobalt dimers of the general formula Co2Cl2Ln  (L = NH3 and PH3)  demonstrates that electron transfer is triggered by asymetric coordination of amine and phosphine to stabilize a mixed-valence Co(II)-Co(0) dimer.	PH.3	111-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	244-250
33529486-3	2021	A detailed analysis of the electronic structure of Cobalt dimers of the general formula Co2Cl2Ln  (L = NH3 and PH3)  demonstrates that electron transfer is triggered by asymetric coordination of amine and phosphine to stabilize a mixed-valence Co(II)-Co(0) dimer.	Amines	195-200	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	244-250
33529486-3	2021	A detailed analysis of the electronic structure of Cobalt dimers of the general formula Co2Cl2Ln  (L = NH3 and PH3)  demonstrates that electron transfer is triggered by asymetric coordination of amine and phosphine to stabilize a mixed-valence Co(II)-Co(0) dimer.	phosphine	205-214	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	244-250
33529486-4	2021	This is consistent with the HSAB statement that both amine and phosphine ligands are required to stabilize the reaction products, respectively Co(II) and Co(0) centers.	Amines	53-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	143-149
33529486-4	2021	This is consistent with the HSAB statement that both amine and phosphine ligands are required to stabilize the reaction products, respectively Co(II) and Co(0) centers.	phosphine	63-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	143-149
33888977-9	2021	Western blot assay indicated that solasodine could significantly inhibit the activation of Cox-2/Akt/GSK3beta signal pathway.	solasodine	34-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-96
33788551-5	2021	The reduction of Co(II) to Co(I) occurs at -2.6 V for a neutral donor but shifts to -3.4 V for an anionic donor.	NAD	27-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-23
33878358-5	2021	In comparison with the popular COX inhibitor Celecoxib, these hydrogels showed an inhibition activity towards COX enzymes with selective inhibition towards COX-2.	Celecoxib	45-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	156-161
33878358-7	2021	BBTU-CS-4 hydrogel exhibited a potent inhibition against COX-2 (IC50 0.42 mug/ml) compared with that observed for the standard Celecoxib (IC50 0.26 mug/ml).	bbtu-cs-4	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-62
33878358-9	2021	BBTU-Cs-4 at a concentration of 7.81 mug/ml is able to kill 100% of the H. pylori and exhibits a preferential ability to inhibit 89.35% of COX-2 than COX-1 (0%).	bbtu-cs-4	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-144
33851772-0	2021	Water-assisted concerted proton-electron transfer at Co(II)-aquo sites in polyoxotungstates with photogenerated RuIII(bpy)33+ oxidant.	Water	0-5	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-59
33851772-0	2021	Water-assisted concerted proton-electron transfer at Co(II)-aquo sites in polyoxotungstates with photogenerated RuIII(bpy)33+ oxidant.	polyoxotungstates	74-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-59
33851772-2	2021	Mechanistic evidence has been acquired indicating that: (i) the one-electron oxidation of Co6 involves Co(II) aquo or Co(II) hydroxo groups (abbreviated as Co6(II)-OH2 and Co6(II)-OH, respectively, whose speciation in aqueous solution is associated to a pKa of 7.6), and generates a Co(III)-OH moiety (Co6(III)-OH), as proven by transient absorption spectroscopy; (ii) at pH > pKa, the Co6(II)-OH   RuIII(bpy)33+ ET occurs via bimolecular kinetics, with a rate constant k close to the diffusion limit and dependent on the ionic strength of the medium, consistent with reaction between charged species; (iii) at pH < pKa, the process involves Co6(II)-OH2   Co6(III)-OH transformation and proceeds via a multiple-site, concerted proton electron transfer (CPET) where water assists the transfer of the proton, as proven by the absence of effect of buffer base concentrations on the rate of the ET and by a H/D kinetic isotope in a range of 1.2 - 1.4.	Water	765-770	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-109
33851772-3	2021	The reactivity of water is ascribed to its organization on the surface of the polyanionic scaffold through hydrogen bond networking involving the Co(II)-OH2 group.	Water	18-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	146-152
33851772-3	2021	The reactivity of water is ascribed to its organization on the surface of the polyanionic scaffold through hydrogen bond networking involving the Co(II)-OH2 group.	Hydrogen	107-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	146-152
33857815-12	2021	Our study suggested that TQ treatment attenuated the UVA-induced oxidative and inflammatory responses, as well as mitochondrial apoptosis in keratinocytes by COX-2 inhibition via activating NrF2/ARE pathway.	thymoquinone	25-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	158-163
33905466-0	2021	Corrigendum: Combination of Tanshinone IIA and Cisplatin Inhibits Esophageal Cancer by Downregulating NF-kappaB/COX-2/VEGF Pathway.	tanshinone	28-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-117
34055228-3	2021	Among all tested compounds, 4-(5-azido-3-(furan-2-yl)-1H-pyrazol-1-yl)benzoic 17 displayed a favorable COX-1 inhibition and selectivity profile (COX-1 IC50 = 0.1 muM, SI >1000 over COX-2).	4-(5-azido-3-(furan-2-yl)-1h-pyrazol-1-yl)benzoic 17	28-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	181-186
33889784-0	2021	Speciation study involving mononuclear binary transition metal (CoII, NiII and CuII) complexes of L-methionine in non-ionic micellar medium.	Metals	57-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-68
33889784-0	2021	Speciation study involving mononuclear binary transition metal (CoII, NiII and CuII) complexes of L-methionine in non-ionic micellar medium.	Methionine	98-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-68
33889784-1	2021	The present work aims to evaluate the binding capacities of binary complexes of L-Methionine with transition metal ions CoII, NiII and CuII in Triton X 100-water mixtures, a non-ionic micellar media of different compositions (0.0-2.5% (v/v)), investigated under the experimental conditions of 0.16 mol/dm3 ionic strength using NaNO3 at a temperature of 303.0 +- 0.1 K Potentiometrically.	Methionine	80-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-124
33889784-1	2021	The present work aims to evaluate the binding capacities of binary complexes of L-Methionine with transition metal ions CoII, NiII and CuII in Triton X 100-water mixtures, a non-ionic micellar media of different compositions (0.0-2.5% (v/v)), investigated under the experimental conditions of 0.16 mol/dm3 ionic strength using NaNO3 at a temperature of 303.0 +- 0.1 K Potentiometrically.	Metals	109-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-124
33595555-10	2021	The sensor showed high selectivity and efficiency for simultaneous determination of Cu(ii), Co(ii), Ni(ii), Hg(ii), and Mn(ii) in drinking, tap, and pond water samples on a single device and detection with the naked eye.	Water	154-159	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-89
33905466-0	2021	Corrigendum: Combination of Tanshinone IIA and Cisplatin Inhibits Esophageal Cancer by Downregulating NF-kappaB/COX-2/VEGF Pathway.	Cisplatin	47-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-117
33336849-2	2021	The reaction of ATBS with transition metal salts of Cu(II), Co(II), Ni(II), and Mn(II) afforded the corresponding ATBS-M complexes.	2-acrylamido-2-methylpropanesulfonate	16-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-66
33336849-2	2021	The reaction of ATBS with transition metal salts of Cu(II), Co(II), Ni(II), and Mn(II) afforded the corresponding ATBS-M complexes.	Metals	37-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-66
33336849-2	2021	The reaction of ATBS with transition metal salts of Cu(II), Co(II), Ni(II), and Mn(II) afforded the corresponding ATBS-M complexes.	2-acrylamido-2-methylpropanesulfonate	114-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-66
33140463-0	2021	Evaluation of the oral administration of alpha-l-guluronic acid on COX-1 and COX-2 gene expression profile in ankylosing spondylitis patients.	guluronic acid	41-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-82
33140463-5	2021	The present study revealed the oral administration effect of G2013 on COX-1 and COX-2 gene expression in AS patients.	2,3,4,5-tetrahydroxy-6-oxohexanoic acid	61-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-85
33140463-7	2021	The results indicate that G2013 is able to reduce the gene expression level of COX-1 and COX-2 enzymes in treated AS patients compared to healthy control.	2,3,4,5-tetrahydroxy-6-oxohexanoic acid	26-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-94
33454616-6	2021	In addition, some lignanamides exhibited moderate cytotoxic activity against HeLa and MCF-7 cells and anti-inflammatory activity against COX-2 in a dose-dependent way.	lignanamides	18-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-142
31543028-2	2021	The maximum adsorption capacity of Co(II) onto Fe3O4@CS-EDTA was 48.78 mg/g at pH = 5 (303 K), which is much higher than that of Fe3O4@Chitosan as well as chitosan.	Edetic Acid	53-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-41
31543028-2	2021	The maximum adsorption capacity of Co(II) onto Fe3O4@CS-EDTA was 48.78 mg/g at pH = 5 (303 K), which is much higher than that of Fe3O4@Chitosan as well as chitosan.	ferryl iron	129-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-41
31543028-3	2021	The kinetics of Co(II) on the Fe3O4@CS-EDTA was consistent with the pseudo-second-order model.	ferryl iron	30-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-22
31543028-3	2021	The kinetics of Co(II) on the Fe3O4@CS-EDTA was consistent with the pseudo-second-order model.	Edetic Acid	36-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-22
31543028-6	2021	Furthermore, after four cycles, the adsorption capacity of Co(II) onto the Fe3O4@CS-EDTA still retained 84.5% of the capacity of the fresh adsorbent, indicating that Fe3O4@CS-EDTA can be considered a promising recyclable adsorbent to remove heavy-metal ions from wastewater.	ferryl iron	75-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
31543028-6	2021	Furthermore, after four cycles, the adsorption capacity of Co(II) onto the Fe3O4@CS-EDTA still retained 84.5% of the capacity of the fresh adsorbent, indicating that Fe3O4@CS-EDTA can be considered a promising recyclable adsorbent to remove heavy-metal ions from wastewater.	Edetic Acid	81-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
31543028-6	2021	Furthermore, after four cycles, the adsorption capacity of Co(II) onto the Fe3O4@CS-EDTA still retained 84.5% of the capacity of the fresh adsorbent, indicating that Fe3O4@CS-EDTA can be considered a promising recyclable adsorbent to remove heavy-metal ions from wastewater.	ferryl iron	166-171	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
31543028-6	2021	Furthermore, after four cycles, the adsorption capacity of Co(II) onto the Fe3O4@CS-EDTA still retained 84.5% of the capacity of the fresh adsorbent, indicating that Fe3O4@CS-EDTA can be considered a promising recyclable adsorbent to remove heavy-metal ions from wastewater.	Edetic Acid	172-179	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
33125572-3	2021	We also demonstrated that oridonin abrogated inflammation through inhibiting the phosphorylation of NF-kappaBp65 as well as its downstream gene (iNOS, COX-2, IL-1beta, and IL-6) level.	oridonin	26-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-156
33618245-4	2021	OBSERVATIONS: This paper reviews randomized controlled trials that showed that celecoxib, a selective COX-2 inhibitor, or low-dose aspirin, which inhibits COX-1 and inhibits/acetylates COX-2, reduced bipolar symptoms in patients on mood stabilizers.	Celecoxib	79-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-107
33618245-4	2021	OBSERVATIONS: This paper reviews randomized controlled trials that showed that celecoxib, a selective COX-2 inhibitor, or low-dose aspirin, which inhibits COX-1 and inhibits/acetylates COX-2, reduced bipolar symptoms in patients on mood stabilizers.	Celecoxib	79-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	185-190
33618245-4	2021	OBSERVATIONS: This paper reviews randomized controlled trials that showed that celecoxib, a selective COX-2 inhibitor, or low-dose aspirin, which inhibits COX-1 and inhibits/acetylates COX-2, reduced bipolar symptoms in patients on mood stabilizers.	Aspirin	131-138	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	185-190
33618245-6	2021	CONCLUSIONS: This clinical evidence is consistent with the hypothesis that low-dose chronic aspirin and celecoxib, which can inhibit COX-2 and enter brain, can be repurposed in bipolar disorder to enhance mood stabilizer effects on arachidonic acid metabolism and neurotransmission.	Aspirin	92-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	133-138
33618245-6	2021	CONCLUSIONS: This clinical evidence is consistent with the hypothesis that low-dose chronic aspirin and celecoxib, which can inhibit COX-2 and enter brain, can be repurposed in bipolar disorder to enhance mood stabilizer effects on arachidonic acid metabolism and neurotransmission.	Celecoxib	104-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	133-138
31543028-0	2021	Facile preparation of EDTA-functionalized magnetic chitosan for removal of co(II) from aqueous solutions.	Edetic Acid	22-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-81
31543028-1	2021	In this study, an efficient adsorption and reusable magnetic ligand material (Fe3O4@Chitosan-EDTA) was synthesized by binding EDTA dianhydride onto magnetic chitosan, and it was employed in removal of Co(II) from aqueous solution.	ferryl iron	78-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	201-207
31543028-1	2021	In this study, an efficient adsorption and reusable magnetic ligand material (Fe3O4@Chitosan-EDTA) was synthesized by binding EDTA dianhydride onto magnetic chitosan, and it was employed in removal of Co(II) from aqueous solution.	Edetic Acid	93-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	201-207
31543028-1	2021	In this study, an efficient adsorption and reusable magnetic ligand material (Fe3O4@Chitosan-EDTA) was synthesized by binding EDTA dianhydride onto magnetic chitosan, and it was employed in removal of Co(II) from aqueous solution.	Edetic Acid	126-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	201-207
31543028-2	2021	The maximum adsorption capacity of Co(II) onto Fe3O4@CS-EDTA was 48.78 mg/g at pH = 5 (303 K), which is much higher than that of Fe3O4@Chitosan as well as chitosan.	ferryl iron	47-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-41
33667839-1	2021	BACKGROUND: Celecoxib (CXB), a selective COX-2 inhibitor NSAID, has exhibited prominent anti-proliferative potential against numerous cancers.	Celecoxib	12-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-46
33667839-1	2021	BACKGROUND: Celecoxib (CXB), a selective COX-2 inhibitor NSAID, has exhibited prominent anti-proliferative potential against numerous cancers.	Celecoxib	23-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-46
33730589-0	2021	COX2 regulates senescence secretome composition and senescence surveillance through PGE2.	Dinoprostone	84-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-4
33783134-7	2021	Density functional theory calculations of the reaction mechanism over the material reveal that the Co(II) sites on G(CN) Co can efficiently interact with hydrazine molecules and promote the N H bond-dissociation steps involved in the HzOR.	hydrazine	154-163	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-105
34004101-4	2021	However, in patients with the F508del mutation, a significant decrease in the synthesis of OPG, COX-2, PGE2 in the osteoblastic formation, and an increase in the activity of the antianabolic NF-kB were found.	f508del	30-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-101
33753764-7	2021	A relationship between COX2/PGE2 in cold (p = 0.0012) and cold/thermoneutral [collapsed, condition and time (p = 0.0243)] was seen, with higher PGE2 associated with higher Tc.	Dinoprostone	144-148	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-27
33753764-7	2021	A relationship between COX2/PGE2 in cold (p = 0.0012) and cold/thermoneutral [collapsed, condition and time (p = 0.0243)] was seen, with higher PGE2 associated with higher Tc.	Technetium	172-174	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-27
33634700-0	2021	Mechanistic Study on Chemiluminescence of Chloranilic Acid by Co(II)-Mediated Fenton-like System.	chloranilic acid	42-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-68
33634700-4	2021	We performed quantum chemical calculations on the entire reaction process of CA/H2O2 and CA/H2O2/Co(II) systems.	Hydrogen Peroxide	92-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-103
33823482-1	2021	The reaction between Co(II) and PMS is an appealing advanced oxidation process (AOP), where multiple reactive oxidizing species (ROS) including high-valent cobalt-oxo [Co(IV)], sulfate radical (SO4 -), and hydroxy radical ( OH) are intertwined together for degrading pollutants.	Promethium	32-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-27
33823482-1	2021	The reaction between Co(II) and PMS is an appealing advanced oxidation process (AOP), where multiple reactive oxidizing species (ROS) including high-valent cobalt-oxo [Co(IV)], sulfate radical (SO4 -), and hydroxy radical ( OH) are intertwined together for degrading pollutants.	reactive oxidizing species	101-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-27
33823482-1	2021	The reaction between Co(II) and PMS is an appealing advanced oxidation process (AOP), where multiple reactive oxidizing species (ROS) including high-valent cobalt-oxo [Co(IV)], sulfate radical (SO4 -), and hydroxy radical ( OH) are intertwined together for degrading pollutants.	ros	129-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-27
33823482-1	2021	The reaction between Co(II) and PMS is an appealing advanced oxidation process (AOP), where multiple reactive oxidizing species (ROS) including high-valent cobalt-oxo [Co(IV)], sulfate radical (SO4 -), and hydroxy radical ( OH) are intertwined together for degrading pollutants.	cobalt-oxo	156-166	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-27
33823482-1	2021	The reaction between Co(II) and PMS is an appealing advanced oxidation process (AOP), where multiple reactive oxidizing species (ROS) including high-valent cobalt-oxo [Co(IV)], sulfate radical (SO4 -), and hydroxy radical ( OH) are intertwined together for degrading pollutants.	co(iv)	168-174	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-27
33823482-1	2021	The reaction between Co(II) and PMS is an appealing advanced oxidation process (AOP), where multiple reactive oxidizing species (ROS) including high-valent cobalt-oxo [Co(IV)], sulfate radical (SO4 -), and hydroxy radical ( OH) are intertwined together for degrading pollutants.	sulfate radical	177-192	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-27
33823482-1	2021	The reaction between Co(II) and PMS is an appealing advanced oxidation process (AOP), where multiple reactive oxidizing species (ROS) including high-valent cobalt-oxo [Co(IV)], sulfate radical (SO4 -), and hydroxy radical ( OH) are intertwined together for degrading pollutants.	so4 -	194-199	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-27
33823482-1	2021	The reaction between Co(II) and PMS is an appealing advanced oxidation process (AOP), where multiple reactive oxidizing species (ROS) including high-valent cobalt-oxo [Co(IV)], sulfate radical (SO4 -), and hydroxy radical ( OH) are intertwined together for degrading pollutants.	Water	206-221	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-27
33823482-4	2021	Using chemical scavenging methods, the role of SO4 - and  OH was also identified, and the major ROS were converted from Co(IV) to radical species with the increase of PMS/Co(II) molar ratio as well as pH value.	ros	96-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	171-177
33823482-4	2021	Using chemical scavenging methods, the role of SO4 - and  OH was also identified, and the major ROS were converted from Co(IV) to radical species with the increase of PMS/Co(II) molar ratio as well as pH value.	co(iv)	120-126	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	171-177
33730589-5	2021	COX2 regulates the expression of multiple inflammatory SASP components through an autocrine feedback loop involving its downstream product, prostaglandin E2 (PGE2), binding to EP4.	Dinoprostone	140-156	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-4
33730589-5	2021	COX2 regulates the expression of multiple inflammatory SASP components through an autocrine feedback loop involving its downstream product, prostaglandin E2 (PGE2), binding to EP4.	Dinoprostone	158-162	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-4
33730589-6	2021	During in vivo hepatocyte RIS, Cox2 is critical to tumor suppression, Cxcl1 expression, and immune-mediated senescence surveillance, partially through PGE2.	Dinoprostone	151-155	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-35
33533759-2	2021	Structural analysis revealed that complex 1 has a zero-dimensional mononuclear structure and complex 2 has a two-dimensional framework where the CoII centers are bridged by bis(monodentate) ligand IPEH.	bis(monodentate)	173-189	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-149
32997790-5	2021	Although the exact mode of action remains unclear, multiple downstream effects of aspirin may interfere with cholangiocarcinogenesis, tumour growth, and metastasis-including inhibiting the COX-2 pathway, preventing platelet aggregation, and modulating certain proteins and signalling.	Aspirin	82-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	189-194
33854702-3	2021	Thus, three series of quinazoline derivatives were prepared and tested for their potential inhibitory activity toward COX-1 and COX-2.	Quinazolines	22-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	128-133
33687113-11	2022	The over-expression of COX-2 by beta-amyloid stimulation was suppressed in bacoside-A pretreated cells in dose-based manner.	bacoside	75-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-28
33514282-4	2021	Exposure of phorbol-12-myristate-13-acetate (PMA)-differentiated THP1 macrophages to the secretome of CSF conditioned ADSCs downregulated both pro-inflammatory (COX-2, TNFalpha) and anti-inflammatory (SOCS3, IL1RA, TGFbeta) genes in these cells.	Tetradecanoylphorbol Acetate	12-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	161-166
33514282-4	2021	Exposure of phorbol-12-myristate-13-acetate (PMA)-differentiated THP1 macrophages to the secretome of CSF conditioned ADSCs downregulated both pro-inflammatory (COX-2, TNFalpha) and anti-inflammatory (SOCS3, IL1RA, TGFbeta) genes in these cells.	Tetradecanoylphorbol Acetate	45-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	161-166
33483030-5	2021	Moreover, the selective uptake of the uranyl ions in multi-ionic aqueous solutions containing the tetravalent Th(IV) ions, trivalent Al(III), Eu(III), and Fe(III) ions, beside the divalent Pb(II), Co(II), Ni(II), Cu(II) ions confirmed the successful creation of a considerable UO2(II) ions selectivity in the U-AOCS construction.	uranyl	38-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	197-203
33621088-8	2021	Together, these experiments reveal the details of the reaction mechanism: reduction of the Co(III) species is followed by dissociation of the bound acetonitrile ligand, subsequent reduction of the unligated Co(II) species to form a Co(I) species is followed by protonation, which occurs at the Cp ring, followed by tautomerization to generate the stable Co(III)-hydride product [HCoCp(dxpe)]+.	co(iii)	91-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	207-213
33621088-8	2021	Together, these experiments reveal the details of the reaction mechanism: reduction of the Co(III) species is followed by dissociation of the bound acetonitrile ligand, subsequent reduction of the unligated Co(II) species to form a Co(I) species is followed by protonation, which occurs at the Cp ring, followed by tautomerization to generate the stable Co(III)-hydride product [HCoCp(dxpe)]+.	NAD	232-237	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	207-213
33621088-8	2021	Together, these experiments reveal the details of the reaction mechanism: reduction of the Co(III) species is followed by dissociation of the bound acetonitrile ligand, subsequent reduction of the unligated Co(II) species to form a Co(I) species is followed by protonation, which occurs at the Cp ring, followed by tautomerization to generate the stable Co(III)-hydride product [HCoCp(dxpe)]+.	co(iii)-hydride	354-369	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	207-213
33621088-8	2021	Together, these experiments reveal the details of the reaction mechanism: reduction of the Co(III) species is followed by dissociation of the bound acetonitrile ligand, subsequent reduction of the unligated Co(II) species to form a Co(I) species is followed by protonation, which occurs at the Cp ring, followed by tautomerization to generate the stable Co(III)-hydride product [HCoCp(dxpe)]+.	hcocp	379-384	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	207-213
33748613-0	2021	Supramolecular Self-Assembly Built by Weak Hydrogen, Chalcogen, and Unorthodox Nonbonded Motifs in 4-(4-Chlorophenyl)-3-[(4-fluorobenzyl)sulfanyl]-5-(thiophen-2-yl)-4H-1,2,4-triazole, a Selective COX-2 Inhibitor: Insights from X-ray and Theoretical Studies.	4-(4-chlorophenyl)-3-[(4-fluorobenzyl)sulfanyl]-5-(thiophen-2-yl)-4h-1,2,4-triazole	99-182	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	196-201
33748613-1	2021	A selective triazole-based COX-2 inhibitor, 4-(4-chlorophenyl)-3-[(4-fluorobenzyl)sulfanyl]-5-(thiophen-2-yl)-4H-1,2,4-triazole, C19H13ClFN3S2, has been synthesized, and its crystal structure was determined at 150 K. Single-crystal X-ray diffraction analysis revealed that the thiophene ring was disordered over two orientations.	Triazoles	12-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-32
33748613-1	2021	A selective triazole-based COX-2 inhibitor, 4-(4-chlorophenyl)-3-[(4-fluorobenzyl)sulfanyl]-5-(thiophen-2-yl)-4H-1,2,4-triazole, C19H13ClFN3S2, has been synthesized, and its crystal structure was determined at 150 K. Single-crystal X-ray diffraction analysis revealed that the thiophene ring was disordered over two orientations.	4-(4-chlorophenyl)-3-[(4-fluorobenzyl)sulfanyl]-5-(thiophen-2-yl)-4h-1,2,4-triazole	44-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-32
33748613-1	2021	A selective triazole-based COX-2 inhibitor, 4-(4-chlorophenyl)-3-[(4-fluorobenzyl)sulfanyl]-5-(thiophen-2-yl)-4H-1,2,4-triazole, C19H13ClFN3S2, has been synthesized, and its crystal structure was determined at 150 K. Single-crystal X-ray diffraction analysis revealed that the thiophene ring was disordered over two orientations.	c19h13clfn3s2	129-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-32
33748613-1	2021	A selective triazole-based COX-2 inhibitor, 4-(4-chlorophenyl)-3-[(4-fluorobenzyl)sulfanyl]-5-(thiophen-2-yl)-4H-1,2,4-triazole, C19H13ClFN3S2, has been synthesized, and its crystal structure was determined at 150 K. Single-crystal X-ray diffraction analysis revealed that the thiophene ring was disordered over two orientations.	Thiophenes	277-286	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-32
33533759-3	2021	In both the complexes, the CoII center has a distorted octahedral geometry with a CoN6 coordination environment, formed by four equatorial N atoms from the neutral ligand and two NCS- at the axial positions.	Nitrogen	84-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-31
33555876-4	2021	Tests for reactive oxygen species (ROS), biomarker expressions (CYP1A1, IL8, COX-2), and mutagenicity (Ames) show that RNG exhaust has toxicity that is comparable or lower than CNG exhaust.	Benzene	119-122	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-82
33791170-0	2021	Erratum: Dehydrocostus lactone, a natural sesquiterpene lactone, suppresses the biological characteristics of glioma, through inhibition of the NF-kappaB/COX-2 signaling pathway by targeting IKKbeta.	dehydrocostus lactone	9-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	154-159
33791170-0	2021	Erratum: Dehydrocostus lactone, a natural sesquiterpene lactone, suppresses the biological characteristics of glioma, through inhibition of the NF-kappaB/COX-2 signaling pathway by targeting IKKbeta.	sesquiterpene lactone	42-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	154-159
32122267-7	2021	The results were indicated that ZINC16934653 and ZINC40484701 demonstrate the highest affinity for the COX-2 binding pocket.	zinc16934653	32-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-108
33850866-1	2021	Background: Imrecoxib, a novel cyclooxygenase (COX-2) selective non-steroidal anti-inflammatory drug (NSAID), has been approved in China for more than 9 years.	Imrecoxib	12-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
33376011-0	2021	Design and synthesis of pyrimidine-5-carbonitrile hybrids as COX-2 inhibitors: Anti-inflammatory activity, ulcerogenic liability, histopathological and docking studies.	5-Cyanopyrimidine	24-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-66
33376011-1	2021	Two new series of 1,3,4-oxadiazole and coumarin derivatives based on pyrimidine-5-carbonitrile scaffold have been synthesized and evaluated for their COX-1/COX-2 inhibitory activity.	coumarin	39-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	156-161
33570794-7	2021	Moreover, PARP-1 silencing and PARP inhibitor olaparib can suppress UVB-induced COX-2 and MMP-1 expression, but enhance TNF-alpha and IL-8 expression.	olaparib	46-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-85
33570794-8	2021	In addition, EGFR silencing or EGFR inhibition by gefitinib can decrease UVB-induced COX-2, TNF-alpha, and IL-8 expression, suggesting EGFR activation via paracrine action can mediate UVB-induced inflammation responses.	Gefitinib	50-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-90
33418245-8	2021	CoQ10 also counteracts inflammatory response mediated after radiation exposure through downregulating intestinal NF-kB expression which subsequently decreased the level of inflammatory cytokine IL-6 and the expression of COX-2.	coenzyme Q10	0-5	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	221-226
32131707-3	2021	Among many of its disease preventing activities, RSV has been shown to ameliorate inflammation by directly binding the COX-1 and COX-2 enzymes, the established targets of common non-steroidal anti-inflammatory drugs (NSAIDs).	Resveratrol	49-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-134
33244799-0	2021	Design, synthesis, biological evaluation, and docking studies of some novel chalcones as selective COX-2 inhibitors.	Chalcones	76-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-104
33244799-1	2021	A new series of chalcones (1-9) possessing an SO2 CH3 COX-2 pharmacophore at the para position of the C-1 phenyl ring was synthesized via the Claisen-Schmidt condensation reaction and examined for their inhibition potential against cyclooxygenase (COX) enzymes.	Chalcones	16-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-59
33244799-3	2021	Enzyme inhibition studies revealed that most of the compounds showed a moderate-to-strong inhibitory activity (IC50  = 0.18-0.34 muM) against the COX-2 enzyme as compared with celecoxib (IC50  = 0.12 muM), ibuprofen (IC50  = 5.33 muM), and nimesulide (IC50  = 1.68 muM).	Celecoxib	176-185	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	146-151
33244799-3	2021	Enzyme inhibition studies revealed that most of the compounds showed a moderate-to-strong inhibitory activity (IC50  = 0.18-0.34 muM) against the COX-2 enzyme as compared with celecoxib (IC50  = 0.12 muM), ibuprofen (IC50  = 5.33 muM), and nimesulide (IC50  = 1.68 muM).	Ibuprofen	206-215	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	146-151
33244799-3	2021	Enzyme inhibition studies revealed that most of the compounds showed a moderate-to-strong inhibitory activity (IC50  = 0.18-0.34 muM) against the COX-2 enzyme as compared with celecoxib (IC50  = 0.12 muM), ibuprofen (IC50  = 5.33 muM), and nimesulide (IC50  = 1.68 muM).	nimesulide	240-250	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	146-151
32122267-7	2021	The results were indicated that ZINC16934653 and ZINC40484701 demonstrate the highest affinity for the COX-2 binding pocket.	STK884531	49-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-108
33652868-0	2021	3D Metal-Organic Frameworks Based on Co(II) and Bithiophendicarboxylate: Synthesis, Crystal Structures, Gas Adsorption, and Magnetic Properties.	Metals	3-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-43
33094540-5	2021	As the rate-limiting enzyme in the biosyntheses of prostanoids, cyclooxygenase (COX), particularly the inducible isoform COX-2, has long been implicated in mechanisms of acute stroke-induced brain injury and inflammation.	Prostaglandins	51-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-126
33668160-8	2021	In this review, we focus on breast cancer and showed that COX-2 is a major promoter of both events, primarily resulting from the activation of prostaglandin (PG) E receptor EP4 on tumor cells, tumor-infiltrating immune cells, and endothelial cells; and the induction of oncogenic microRNAs.	Prostaglandins	143-156	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
33668160-8	2021	In this review, we focus on breast cancer and showed that COX-2 is a major promoter of both events, primarily resulting from the activation of prostaglandin (PG) E receptor EP4 on tumor cells, tumor-infiltrating immune cells, and endothelial cells; and the induction of oncogenic microRNAs.	Prostaglandins	158-160	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
33293086-0	2021	Enhanced removal of Co(II) and Ni(II) from high-salinity aqueous solution using reductive self-assembly of three-dimensional magnetic fungal hyphal/graphene oxide nanofibers.	graphene oxide	148-162	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-26
33215788-0	2021	Double Fence Porphyrins that are Compatible with CoII/III Electrolyte for High Efficiency Dye-Sensitized Solar Cells.	Porphyrins	13-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-53
33615958-7	2021	COX-2 ir-cell numbers were attenuated for EXP + BA in CA1 (p = 0.02) and PVN (p = 0.015) compared to EXP.	Barium	48-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
33293086-2	2021	Herein, three-dimensional magnetic fungal hyphal/graphene oxide nanofibers (MFHGs) were assembled by a reductive self-assembly (RSA) strategy for the efficient capture of Co(II) and Ni(II) from high-salinity aqueous solution.	graphene oxide	49-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	171-177
33293086-5	2021	The results of batch removal experiments showed that the maximum removal capacity of MFHGs for Ni(II) and Co(II) was 97.44 and 104.34 mg/g, respectively, in 2 g/L Na2SO4 aqueous solution with a pH of 6.0 at 323 K, and the effects of initial pH and ionic strength on Co(II) and Ni(II) removal were explored.	sodium sulfate	163-169	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-112
33293086-5	2021	The results of batch removal experiments showed that the maximum removal capacity of MFHGs for Ni(II) and Co(II) was 97.44 and 104.34 mg/g, respectively, in 2 g/L Na2SO4 aqueous solution with a pH of 6.0 at 323 K, and the effects of initial pH and ionic strength on Co(II) and Ni(II) removal were explored.	Nickel(2+)	277-283	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-112
33293086-6	2021	Yield residue analysis indicated that the high porosity and oxygen-containing functional groups of MFHGs remarkably improved their Co(II)- and Ni(II)-removal capacities.	Oxygen	60-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-137
33293086-7	2021	According to the analysis, hydroxyl groups and amine groups participated in the chemical reaction of Co(II) and Ni(II) removal, and cation-exchange chemical adsorption was dominant during the Co(II)- and Ni(II)-removal process.	Hydroxyl Radical	27-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-107
33293086-7	2021	According to the analysis, hydroxyl groups and amine groups participated in the chemical reaction of Co(II) and Ni(II) removal, and cation-exchange chemical adsorption was dominant during the Co(II)- and Ni(II)-removal process.	Amines	47-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-107
33596205-0	2021	Robust COX-2-mediated prostaglandin response may drive arthralgia and bone destruction in patients with chronic inflammation post-chikungunya.	Prostaglandins	22-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	7-12
33608553-0	2021	Calculating metalation in cells reveals CobW acquires CoII for vitamin B12 biosynthesis while related proteins prefer ZnII.	Vitamin B 12	63-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-58
33608553-4	2021	We use the calculator to understand the function and mechanism of GTPase CobW, a predicted CoII-chaperone for vitamin B12.	Vitamin B 12	110-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-95
33608553-5	2021	Upon binding nucleotide (GTP) and MgII, CobW assembles a high-affinity site that can obtain CoII or ZnII from the intracellular milieu.	Guanosine Triphosphate	25-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-96
33608553-7	2021	Thus, CoII is the cognate metal.	Metals	26-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	6-10
33595097-6	2022	KEY RESULTS: PF 9184 and Troglitazone, in a time and dose-dependent manner, were shown to significantly modulate leukocyte infiltration, myeloperoxidase activity, and the expression of COX-2/mPGES-1, NF-kB/IkB-alpha and mPTGDS-1/PPAR-gamma induced by IL-17.	N-(3',4'-dichlorobiphenyl-4-yl)-4-hydroxy-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide	13-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	185-190
33595097-6	2022	KEY RESULTS: PF 9184 and Troglitazone, in a time and dose-dependent manner, were shown to significantly modulate leukocyte infiltration, myeloperoxidase activity, and the expression of COX-2/mPGES-1, NF-kB/IkB-alpha and mPTGDS-1/PPAR-gamma induced by IL-17.	Troglitazone	25-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	185-190
33596205-14	2021	In sharp contrast, dexamethasone was able to control the capacity of pro-inflammatory cytokines, IL-1beta as well as TNFalpha, to stimulate mRNA levels of cPLA2alpha, COX-2 and mPGES-1.	Dexamethasone	19-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	167-172
33596205-15	2021	These original data argue for a concerted action of CHIKV (including viral RNA) and cytokines plausibly released from recruited leukocytes to drive a major COX-2-mediated PGE2 proinflammatory responses to induce viral arthritis.	Dinoprostone	171-175	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	156-161
33427831-5	2021	The Bax/Bcl2 expression ratio was increased up to 11-fold in cells pre-treated with 60 muM limonoids for 48 h. Apart from this, the limonoids also induced the expression of p21, and exhibited anti-inflammatory activity through decreasing the expression of cox-2, NF-kappaB and IL-6.	Limonins	132-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	256-261
33477020-0	2021	Design, synthesis and biological evaluation of novel indanone containing spiroisoxazoline derivatives with selective COX-2 inhibition as anticancer agents.	indacrinone	53-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-122
33477020-0	2021	Design, synthesis and biological evaluation of novel indanone containing spiroisoxazoline derivatives with selective COX-2 inhibition as anticancer agents.	spiroisoxazoline	73-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-122
33477020-1	2021	OBJECTIVE: A new family of 3"-(Mono, di or tri-substituted phenyl)-4"-(4-(methylsulfonyl) phenyl) spiroisoxazoline derivatives containing indanone spirobridge was designed, synthesized, and evaluated for their selective COX-2 inhibitory potency and cytotoxicity on different cell lines.	indacrinone	138-146	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	220-225
33477020-7	2021	RESULTS: The docking results showed that the synthesized compounds were able to form hydrogen bonds with COX-2 involving methyl sulfonyl, spiroisoxazoline, meta-methoxy and fluoro functional groups.	Hydrogen	85-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-110
33477020-7	2021	RESULTS: The docking results showed that the synthesized compounds were able to form hydrogen bonds with COX-2 involving methyl sulfonyl, spiroisoxazoline, meta-methoxy and fluoro functional groups.	methyl sulfonyl	121-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-110
33477020-7	2021	RESULTS: The docking results showed that the synthesized compounds were able to form hydrogen bonds with COX-2 involving methyl sulfonyl, spiroisoxazoline, meta-methoxy and fluoro functional groups.	spiroisoxazoline	138-154	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-110
33477020-7	2021	RESULTS: The docking results showed that the synthesized compounds were able to form hydrogen bonds with COX-2 involving methyl sulfonyl, spiroisoxazoline, meta-methoxy and fluoro functional groups.	meta-methoxy	156-168	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-110
33477020-7	2021	RESULTS: The docking results showed that the synthesized compounds were able to form hydrogen bonds with COX-2 involving methyl sulfonyl, spiroisoxazoline, meta-methoxy and fluoro functional groups.	Fluorine	173-179	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-110
33477020-8	2021	Spiroisoxazoline derivatives containing methoxy group at the C-3" phenyl ring meta position (9f and 9g) showed superior selectivity with higher potency of inhibiting COX-2 enzyme.	spiroisoxazoline	0-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	166-171
33427831-5	2021	The Bax/Bcl2 expression ratio was increased up to 11-fold in cells pre-treated with 60 muM limonoids for 48 h. Apart from this, the limonoids also induced the expression of p21, and exhibited anti-inflammatory activity through decreasing the expression of cox-2, NF-kappaB and IL-6.	Limonins	91-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	256-261
33580578-0	2021	DeepCys: structure-based multiple cysteine function prediction method trained on deep neural network: case study on Domains of Unknown Functions (DUFs) belonging to COX2 domains.	Cysteine	34-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	165-169
33161270-10	2021	The structure and geometry of the complex formed between Cu(II) and H2L ligand was identified via isolation of the solid complex; Co(II) an Ni(II) complexes were synthesized as well.	cu(ii)	57-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	130-136
33161270-10	2021	The structure and geometry of the complex formed between Cu(II) and H2L ligand was identified via isolation of the solid complex; Co(II) an Ni(II) complexes were synthesized as well.	h2l	68-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	130-136
33161270-10	2021	The structure and geometry of the complex formed between Cu(II) and H2L ligand was identified via isolation of the solid complex; Co(II) an Ni(II) complexes were synthesized as well.	Nickel(2+)	140-146	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	130-136
33161270-11	2021	The geometrical structure around the metal centers were proved to be square planar for Cu(II) complex and tetrahedral for Co(II) an Ni(II) complexes.	Metals	37-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-128
33161270-11	2021	The geometrical structure around the metal centers were proved to be square planar for Cu(II) complex and tetrahedral for Co(II) an Ni(II) complexes.	Nickel(2+)	132-138	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-128
33580578-11	2021	This tool was used to elucidate the cysteine functions on domains of unknown functions (DUFs) belonging to cytochrome C oxidase subunit-II (COX2) like transmembrane domains.	Cysteine	36-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-138
33580578-11	2021	This tool was used to elucidate the cysteine functions on domains of unknown functions (DUFs) belonging to cytochrome C oxidase subunit-II (COX2) like transmembrane domains.	Cysteine	36-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-144
33567596-6	2021	Our results showed that (i) caffeic acid targets COX-2 and its product PGE2 as well as the biosynthesis of IL-8 in the IL-1beta-treated cells and (ii) inhibits AGE formation, which could be related to (iii) the high chelating activity exerted.	caffeic acid	28-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-54
33578781-5	2021	Moreover, the stimulatory effects of H2O2 on cellular senescence are associated with oxidative stress induction, such as excessive ROS production and NADPH consumption, telomere DNA damage induction, and upregulation of senescence-associated secretory phenotype factors (IL-1beta, IL-6, IL-8, COX-2, and TNF-alpha) as well as NF-kappaB activation, which were all blocked by FK866.	Hydrogen Peroxide	37-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	293-298
33566156-4	2021	The MAF-5-CoII NS-modified screen-printed electrode (MAF-5-CoII NS/SPE) was used for nonenzymatic detection of glucose in diluted human blood plasma (BP) samples with phosphate buffer saline (PBS, pH 7.4) and NaOH (0.1 M, pH 13.0) solutions.	Glucose	111-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-14
33566156-4	2021	The MAF-5-CoII NS-modified screen-printed electrode (MAF-5-CoII NS/SPE) was used for nonenzymatic detection of glucose in diluted human blood plasma (BP) samples with phosphate buffer saline (PBS, pH 7.4) and NaOH (0.1 M, pH 13.0) solutions.	Glucose	111-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-63
33566156-4	2021	The MAF-5-CoII NS-modified screen-printed electrode (MAF-5-CoII NS/SPE) was used for nonenzymatic detection of glucose in diluted human blood plasma (BP) samples with phosphate buffer saline (PBS, pH 7.4) and NaOH (0.1 M, pH 13.0) solutions.	phosphate buffer saline	167-190	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-14
33566156-4	2021	The MAF-5-CoII NS-modified screen-printed electrode (MAF-5-CoII NS/SPE) was used for nonenzymatic detection of glucose in diluted human blood plasma (BP) samples with phosphate buffer saline (PBS, pH 7.4) and NaOH (0.1 M, pH 13.0) solutions.	phosphate buffer saline	167-190	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-63
33566156-5	2021	The MAF-5-CoII NS nanozyme displayed good redox activity in both neutral and alkaline media with the formation of CoII/CoIII redox pair, which induced the catalytic oxidation of glucose.	Glucose	178-185	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-14
33566156-5	2021	The MAF-5-CoII NS nanozyme displayed good redox activity in both neutral and alkaline media with the formation of CoII/CoIII redox pair, which induced the catalytic oxidation of glucose.	Glucose	178-185	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-118
33566156-11	2021	Thus, MAF-5-CoII NS is a promising nanozyme for the development of the disposable type of sensor for glucose detection in human body fluids.	Glucose	101-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-16
33264886-7	2021	The co-existence of Fe and Co in various valence states in catalyst might improve the conversion of Co(III)/Co(II) and Fe(III)/Fe(II), which would increase the catalytic activity in catalytic ozonation process.	Iron	20-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-114
33562298-7	2021	However, co-treatment with TUDCA alleviated inflammatory response induced by IL-1beta, as shown by down regulation of Il-1beta, Il-6, Il-8 and Cox2, and increased the expression of antioxidant enzyme Sod2.	ursodoxicoltaurine	27-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	143-147
33264886-7	2021	The co-existence of Fe and Co in various valence states in catalyst might improve the conversion of Co(III)/Co(II) and Fe(III)/Fe(II), which would increase the catalytic activity in catalytic ozonation process.	Cobalt	27-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-114
33644540-11	2021	Results: The upregulated iNOS, excessive production of NO, IL-6, and MCP-1, and activated COX-2/PGE2 signaling pathways in the astrocytes induced by isoflurane were significantly reversed by the introduction of roflumilast, in a dose-dependent manner.	Dinoprostone	96-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-95
33029886-4	2021	The present work aims to review synthetic strategies of isoxazolines and its role in enhancement of biological activity of natural products and synthetic molecules such as anti-TB, COX-1 inhibitor, COX-2 inhibitor (Valdecoxib), nicotinic receptor modulators, MIF inhibitor and many more.	isoxazolines	56-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	198-203
33491441-1	2021	Cyclooxygenase-1 (COX-1) and its isozyme COX-2 are key enzymes in the syntheses of prostanoids.	Prostaglandins	83-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-46
33507306-5	2021	We found that tunicamycin-induced ER stress inhibited NF-kappaB activation and pro-inflammatory cytokine (IL-6 and COX2) production in TNF-alpha- or IL-1beta-treated normal endometrial stromal cells (NECSs).	Tunicamycin	14-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-119
33507306-7	2021	Similarly, progesterone increased A20 and C/EBPbeta expression through upregulation of ER stress in NESCs, resulting in inhibition of NF-kappaB activity and IL-6 and COX2 production.	Progesterone	11-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	166-170
33507306-9	2021	In contrast, upregulation of ER stress by tunicamycin significantly reduced IL-6 and COX2 production by inhibiting NF-kappaB activity in ECSCs.	Tunicamycin	42-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-89
33644540-11	2021	Results: The upregulated iNOS, excessive production of NO, IL-6, and MCP-1, and activated COX-2/PGE2 signaling pathways in the astrocytes induced by isoflurane were significantly reversed by the introduction of roflumilast, in a dose-dependent manner.	Isoflurane	149-159	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-95
33433551-1	2021	We are reporting the synthesis and structural characterization of a new hexanuclear Co(ii)/Co(iii) complex starting from a versatile pivalate cobalt precursor and the racemic mixture of a chelating Schiff base type ligand.	Cobalt	142-148	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-90
33433551-1	2021	We are reporting the synthesis and structural characterization of a new hexanuclear Co(ii)/Co(iii) complex starting from a versatile pivalate cobalt precursor and the racemic mixture of a chelating Schiff base type ligand.	Schiff Bases	198-209	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-90
33433551-1	2021	We are reporting the synthesis and structural characterization of a new hexanuclear Co(ii)/Co(iii) complex starting from a versatile pivalate cobalt precursor and the racemic mixture of a chelating Schiff base type ligand.	co(iii)	91-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-90
33433551-1	2021	We are reporting the synthesis and structural characterization of a new hexanuclear Co(ii)/Co(iii) complex starting from a versatile pivalate cobalt precursor and the racemic mixture of a chelating Schiff base type ligand.	Pivalate	133-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-90
33644540-11	2021	Results: The upregulated iNOS, excessive production of NO, IL-6, and MCP-1, and activated COX-2/PGE2 signaling pathways in the astrocytes induced by isoflurane were significantly reversed by the introduction of roflumilast, in a dose-dependent manner.	Roflumilast	211-222	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-95
33644540-13	2021	In addition, the COX-2/PGE2 signaling pathway activated by isoflurane can be inactivated by recombinant human BDNF.	Dinoprostone	23-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22
33644540-13	2021	In addition, the COX-2/PGE2 signaling pathway activated by isoflurane can be inactivated by recombinant human BDNF.	Isoflurane	59-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22
33644540-14	2021	Finally, the regulatory effect of roflumilast against the isoflurane-activated COX-2/PGE2 signaling pathway was significantly blocked by ANA-12, which is a BDNF inhibitor.	Roflumilast	34-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-84
33644540-14	2021	Finally, the regulatory effect of roflumilast against the isoflurane-activated COX-2/PGE2 signaling pathway was significantly blocked by ANA-12, which is a BDNF inhibitor.	Isoflurane	58-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-84
33644540-14	2021	Finally, the regulatory effect of roflumilast against the isoflurane-activated COX-2/PGE2 signaling pathway was significantly blocked by ANA-12, which is a BDNF inhibitor.	Dinoprostone	85-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-84
33644540-14	2021	Finally, the regulatory effect of roflumilast against the isoflurane-activated COX-2/PGE2 signaling pathway was significantly blocked by ANA-12, which is a BDNF inhibitor.	ANA-12	137-143	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-84
33581645-10	2021	On the other hand, the active process of AA hydrolysis from cell membrane phospholipids and decreased transcription of CREB1, COX-2 and PTGER4 may explain the reported findings of a blunted niacin response in schizophrenia.	Niacin	190-196	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-131
33185808-1	2021	The synthesis of eight novel Zn(II), Co(II), Cu(II), Ni(II) and Pt(II) complexes (2-9) derived from the ONNO tetradentate coumarin Schiff-Base donor ligands, L1 and the novel L2, was performed.	coumarin schiff-base	122-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-43
33040178-8	2021	The non-selective COX inhibitor aspirin and the selective COX-2 inhibitor celecoxib increased sensitivity of several human and mouse CRC cell lines to EPA in vitro.	Celecoxib	74-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
33040178-8	2021	The non-selective COX inhibitor aspirin and the selective COX-2 inhibitor celecoxib increased sensitivity of several human and mouse CRC cell lines to EPA in vitro.	Eicosapentaenoic Acid	151-154	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
33581645-12	2021	INTERPRETATION: These results suggested that the activation of AA hydrolysis and the imbalance in COX-1 and COX-2 expression are involved in the pathogenesis of schizophrenia and blunting of the niacin flush response.	Niacin	195-201	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-113
33169484-5	2021	We hypothesize that COX16 could play a role in the copper delivery route of the COX2 module as part of the complex IV assembly.	Copper	51-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-84
33096205-8	2021	Also, BDDE-treated cells exhibited higher COX-2 expression at 100 ppm.	1,4-bis(2,3-epoxypropoxy)butane	6-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47
31928159-10	2021	The target compounds showed low to moderate cytotoxicity activities.The obtained results revealed that the synthesized complexes are stronger antibacterial agents against the gram-positive than gram-negative bacteria.In the present study, for the first time we reported two Co(II) complexes bearing 5,5"-dimethyl-2,2"-bipyridine ligands.	4,4'-dimethyl-2,2'-bipyridine	299-328	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	274-280
33469997-7	2021	As expected, whether the clinical investigation or cultured thyroid cells demonstrated that BPA at a concentration compatible with human exposed levels (10-7  M) synergized with the BRAFV600E mutation promoted EMT via the activation of ERK-Cox2 signalling pathway.	bisphenol A	92-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	240-244
33487125-3	2021	Prostaglandin E2 (PGE2) acts downstream of NSAID target COX-2, a cyclooxygenase, to activate several G-protein coupled receptors (GPCR) including EP2, which is now reported to reduce glycolysis and oxidative phosphorylation during aging by increasing glycogen synthesis and polarizing myeloid cells toward the M1 pro-inflammatory phenotype.	Dinoprostone	0-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-79
33487125-3	2021	Prostaglandin E2 (PGE2) acts downstream of NSAID target COX-2, a cyclooxygenase, to activate several G-protein coupled receptors (GPCR) including EP2, which is now reported to reduce glycolysis and oxidative phosphorylation during aging by increasing glycogen synthesis and polarizing myeloid cells toward the M1 pro-inflammatory phenotype.	Dinoprostone	18-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-79
33487125-3	2021	Prostaglandin E2 (PGE2) acts downstream of NSAID target COX-2, a cyclooxygenase, to activate several G-protein coupled receptors (GPCR) including EP2, which is now reported to reduce glycolysis and oxidative phosphorylation during aging by increasing glycogen synthesis and polarizing myeloid cells toward the M1 pro-inflammatory phenotype.	Glycogen	251-259	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-79
33437981-0	2021	Morphology dependent interaction between Co(II)-tetraphenylporphyrin and the MgO(100) surface.	mgo(100)	77-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-47
33537484-0	2021	The use of complex formation manner for spectrophotometric analysis of gatifloxacin drug based on Co(II), Ni(II) and La(III) ions.	Gatifloxacin	71-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-104
33504835-1	2021	A magnetic Fe3O4@MgAl-layered double hydroxide (MLDH) nanocomposite was successfully synthesized and applied as an effective adsorbent for preconcentration of trace As(III), Cd(II), Cr(III), Co(II), Ni(II), and Pb(II) ions from complex matrices.	ferryl iron	11-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	191-197
33504835-1	2021	A magnetic Fe3O4@MgAl-layered double hydroxide (MLDH) nanocomposite was successfully synthesized and applied as an effective adsorbent for preconcentration of trace As(III), Cd(II), Cr(III), Co(II), Ni(II), and Pb(II) ions from complex matrices.	hydroxide ion	37-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	191-197
33504835-9	2021	The proposed method was successfully applied for the analysis of the As(III), Cd(II), Cr(III), Co(II), Ni(II), and Pb(II) ions in different environmental water samples.	Water	154-159	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-101
28520369-2	2012	These enzymes catalyze pathways that play a key role in the generation of the inflammatory response; however, celecoxib, selectively inhibits COX-2.	Celecoxib	110-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	142-147
33400528-1	2021	Both [CoII(qpy)(H2O)2]2+ and [FeII(qpy)(H2O)2]2+ (with qpy = 2,2":6",2"":6"",2"""-quaterpyridine) are efficient homogeneous electrocatalysts and photoelectrocatalysts for the reduction of CO2 to CO.	,2"":6"",2"""-quaterpyridine	68-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	6-10
33045697-2	2021	These water-durable frameworks exhibit varied hydrogen production rates of 361.2, 271.3, and 327.5 mumol g-1 h-1 in 12 hour due to their slightly different donor environments of the octahedral CdII and CoII ions.	Water	6-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	202-206
33494773-11	2021	CONCLUSIONS: Considering clinical trials targeting PGE2 production largely have focused on the inhibition of Cox1 or Cox2 that showed cardiac toxicity, our data suggest an alternative way for suppressing PGE2 production via the inhibition of miR-155.	Dinoprostone	51-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-121
33484117-5	2021	The relevance of vascular COX-2-derived prostacyclin (PGI2) in endothelial thromboresistance and atheroprotection is clearly shown by animal and human models and by the adverse cardiovascular effects exerted by COX-2 inhibitors in humans.	Epoprostenol	40-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-31
33484117-5	2021	The relevance of vascular COX-2-derived prostacyclin (PGI2) in endothelial thromboresistance and atheroprotection is clearly shown by animal and human models and by the adverse cardiovascular effects exerted by COX-2 inhibitors in humans.	Epoprostenol	40-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	211-216
33484117-5	2021	The relevance of vascular COX-2-derived prostacyclin (PGI2) in endothelial thromboresistance and atheroprotection is clearly shown by animal and human models and by the adverse cardiovascular effects exerted by COX-2 inhibitors in humans.	Epoprostenol	54-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-31
33484117-5	2021	The relevance of vascular COX-2-derived prostacyclin (PGI2) in endothelial thromboresistance and atheroprotection is clearly shown by animal and human models and by the adverse cardiovascular effects exerted by COX-2 inhibitors in humans.	Epoprostenol	54-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	211-216
32991759-2	2021	An appropriately tuned cationic pincer cobalt(I) complex featuring a central silylene donor reacts with CO2 to afford a bimetallic siloxane featuring two Co(II) centers with liberation of CO, and reaction with ethylene yields a similar bimetallic complex with an ethylene bridge.	Cobalt	39-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	154-160
33325957-1	2021	Three new NiII/CoII-metal organic frameworks were self-assembled by the reaction of C3 symmetric 1,3,5-tribenzoic acid (H3BTC) and 2,4,6-tris(4-pyridyl)-1,3,5-triazine (4-TPT) ligands and NiII/CoII salts under solvothermal conditions.	Metals	20-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-19
33325957-1	2021	Three new NiII/CoII-metal organic frameworks were self-assembled by the reaction of C3 symmetric 1,3,5-tribenzoic acid (H3BTC) and 2,4,6-tris(4-pyridyl)-1,3,5-triazine (4-TPT) ligands and NiII/CoII salts under solvothermal conditions.	Metals	20-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	193-197
33325957-1	2021	Three new NiII/CoII-metal organic frameworks were self-assembled by the reaction of C3 symmetric 1,3,5-tribenzoic acid (H3BTC) and 2,4,6-tris(4-pyridyl)-1,3,5-triazine (4-TPT) ligands and NiII/CoII salts under solvothermal conditions.	1,3,5-tribenzoic acid	97-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-19
33325957-1	2021	Three new NiII/CoII-metal organic frameworks were self-assembled by the reaction of C3 symmetric 1,3,5-tribenzoic acid (H3BTC) and 2,4,6-tris(4-pyridyl)-1,3,5-triazine (4-TPT) ligands and NiII/CoII salts under solvothermal conditions.	h3btc	120-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-19
33325957-1	2021	Three new NiII/CoII-metal organic frameworks were self-assembled by the reaction of C3 symmetric 1,3,5-tribenzoic acid (H3BTC) and 2,4,6-tris(4-pyridyl)-1,3,5-triazine (4-TPT) ligands and NiII/CoII salts under solvothermal conditions.	2,4,6-Tri(4-pyridyl)-1,3,5-triazine	131-167	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-19
33325957-1	2021	Three new NiII/CoII-metal organic frameworks were self-assembled by the reaction of C3 symmetric 1,3,5-tribenzoic acid (H3BTC) and 2,4,6-tris(4-pyridyl)-1,3,5-triazine (4-TPT) ligands and NiII/CoII salts under solvothermal conditions.	4-tpt	169-174	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-19
33125815-5	2021	In contrast, both Co(II) and Co(III) complexes are also studied as catalysts to utilize air for olefin and alkane oxidation reactions, however not resulting in product formation.	Alkenes	96-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-24
32991759-2	2021	An appropriately tuned cationic pincer cobalt(I) complex featuring a central silylene donor reacts with CO2 to afford a bimetallic siloxane featuring two Co(II) centers with liberation of CO, and reaction with ethylene yields a similar bimetallic complex with an ethylene bridge.	Carbon Dioxide	104-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	154-160
33125815-5	2021	In contrast, both Co(II) and Co(III) complexes are also studied as catalysts to utilize air for olefin and alkane oxidation reactions, however not resulting in product formation.	Alkanes	107-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-24
32991759-2	2021	An appropriately tuned cationic pincer cobalt(I) complex featuring a central silylene donor reacts with CO2 to afford a bimetallic siloxane featuring two Co(II) centers with liberation of CO, and reaction with ethylene yields a similar bimetallic complex with an ethylene bridge.	Siloxanes	131-139	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	154-160
32991759-2	2021	An appropriately tuned cationic pincer cobalt(I) complex featuring a central silylene donor reacts with CO2 to afford a bimetallic siloxane featuring two Co(II) centers with liberation of CO, and reaction with ethylene yields a similar bimetallic complex with an ethylene bridge.	Carbon Monoxide	104-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	154-160
32991759-2	2021	An appropriately tuned cationic pincer cobalt(I) complex featuring a central silylene donor reacts with CO2 to afford a bimetallic siloxane featuring two Co(II) centers with liberation of CO, and reaction with ethylene yields a similar bimetallic complex with an ethylene bridge.	ethylene	210-218	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	154-160
33519947-5	2021	The binding strength of core active compounds and target proteins was verified through molecular docking, and the direct effects of Shiyifang Vinum and four monomer compounds on COX-2 enzyme activity were detected through an in vitro enzyme activity test.	shiyifang vinum	132-147	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	178-183
33249151-5	2021	The parameters for the adsorption of Co(II) ions by NaAlg-g-DPA were also determined.	naalg	52-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-43
33249151-5	2021	The parameters for the adsorption of Co(II) ions by NaAlg-g-DPA were also determined.	g-dpa	58-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-43
33249151-8	2021	The findings from this research show that NaAlg-g-DPA has capability to remove Co (II) from aqueous solutions.	naalg-g-dpa	42-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-86
33519947-8	2021	In vitro validation experiments showed that both the Shiyifang Vinum and the four monomer compounds could inhibit the activity of COX-2.	shiyifang vinum	53-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	130-135
33278481-4	2021	Herein, we report the use of bio-resorbable poly(ester urea) (PEU) films that controllably deliver a non-opioid COX-2 inhibitor, etoricoxib, in vivo and in vitro as a model system for post-surgical pain control.	Urea	55-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-117
33441691-9	2021	Further, COX-2 expression and LD amount presented a significant positive correlation and were detected co-localized in EAC, but not in ESCC, suggesting that LD may be the site for eicosanoid production in EAC.	Eicosanoids	180-190	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	9-14
33441348-3	2021	NSAIDs inhibit the enzymes cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2), which mediate the production of prostaglandins (PGs).	Prostaglandins	114-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
33441348-3	2021	NSAIDs inhibit the enzymes cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2), which mediate the production of prostaglandins (PGs).	Prostaglandins	130-133	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
33278481-4	2021	Herein, we report the use of bio-resorbable poly(ester urea) (PEU) films that controllably deliver a non-opioid COX-2 inhibitor, etoricoxib, in vivo and in vitro as a model system for post-surgical pain control.	poly(ester-urea)	62-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-117
33430037-10	2021	PTGS2/COX2 expression trended lower in aspirin users, but not with tumor response.	Aspirin	39-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	6-10
33080102-3	2021	Strong agostic interactions with the "C-H"-groups of the cyclohexyl substituents result in an unusual low spin square planar Co II complex, which is unreactive towards external substrates.	Carbon	38-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-130
33489875-5	2020	At all three time points, Emodin (50 mg/kg) reduced inflammatory cell (i.e. CD11b+ and F4/80+) recruitment, cytokine (i.e. TNFalpha, IL1alpha/beta, IL6, CCL2, CXCL5) and pro-inflammatory enzymes (i.e. COX-2, NOS2) expression in the tumor microenvironment, while promoting recruitment of CD3+ T lymphocytes at 14 weeks.	Emodin	26-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	201-206
33300509-0	2021	Accessing water processable cyanido bridged chiral heterobimetallic Co(II)-Fe(III) one dimensional network.	Water	10-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-74
33300509-0	2021	Accessing water processable cyanido bridged chiral heterobimetallic Co(II)-Fe(III) one dimensional network.	cyanido	28-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-74
33300509-0	2021	Accessing water processable cyanido bridged chiral heterobimetallic Co(II)-Fe(III) one dimensional network.	ferric sulfate	75-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-74
33300509-1	2021	A water processable cyanido bridged extended chiral heterobimetallic Co(ii)-Fe(iii) network is assembled.	Water	2-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-75
33300509-1	2021	A water processable cyanido bridged extended chiral heterobimetallic Co(ii)-Fe(iii) network is assembled.	cyanido	20-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-75
33300509-1	2021	A water processable cyanido bridged extended chiral heterobimetallic Co(ii)-Fe(iii) network is assembled.	ferric sulfate	76-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-75
33505216-9	2021	Moreover, GA is capable of blocking prostaglandin-E2 synthesis via blockade of cyclooxygenase- (COX-) 2 resulting in concurrent augmentation nitric oxide production through the enhancement of iNOS2 mRNA secretion in Leishmania-infected macrophages.	Glycyrrhetinic Acid	10-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-103
33080102-0	2021	Isomerization Reactions in Anionic Mesoionic Carbene-Borates and Control of Properties and Reactivities in the resulting CoII Complexes through Agostic Interactions.	carbene-borates	45-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-125
33400072-1	2021	2,5-Dimethyl-celecoxib (DMC) is a close structural analog of the selective COX-2 inhibitor celecoxib that lacks COX-2-inhibitory function.	2,5-dimethylcelecoxib	0-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
33400072-1	2021	2,5-Dimethyl-celecoxib (DMC) is a close structural analog of the selective COX-2 inhibitor celecoxib that lacks COX-2-inhibitory function.	2,5-dimethylcelecoxib	0-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-117
33400072-1	2021	2,5-Dimethyl-celecoxib (DMC) is a close structural analog of the selective COX-2 inhibitor celecoxib that lacks COX-2-inhibitory function.	2,5-dimethylcelecoxib	24-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
33400072-1	2021	2,5-Dimethyl-celecoxib (DMC) is a close structural analog of the selective COX-2 inhibitor celecoxib that lacks COX-2-inhibitory function.	Celecoxib	13-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
33080102-5	2021	That complex displays a high spin tetrahedral Co II center, which is reactive towards external substrates including dioxygen.	Oxygen	116-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
32909857-0	2021	Calcitriol inhibits COX-1 and COX-2 expressions of renal vasculature in hypertension: Reactive oxygen species involved?	Calcitriol	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-35
32909857-10	2021	Taken together, our findings showed that COX-1 and COX-2 are positively involved in the renovascular dysfunction in hypertension and via VDR, calcitriol benefits renovasular function by suppressing COX-1 and COX-2 expressions.	Calcitriol	142-152	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	208-213
32909857-11	2021	Furthermore, ROS is involved in the COX-1 and COX-2 up-regulations of renal arteries, maybe serving as a mediator in the inhibitory action of calcitriol on COX expression.	Reactive Oxygen Species	13-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
33406583-11	2021	The PLGA-DEX NPs (0.1 mg/kg) significantly reduced macroscopic and histopathological scores, decreased MDA, TNF-alpha and IL-1beta levels, immunostaining for NF-kappaB, COX-2, TGF-beta, and suppressed NF-kappaB p65 mRNA expression, but increased GILZ and MKP1 expression.	Dextromethorphan	9-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	169-174
32909857-9	2021	Studies on human renal artery also revealed the beneficial action of calcitriol is mediated by suppressing COX-1 and COX-2 expressions, dependent on vitamin D receptor (VDR) activation.	Calcitriol	69-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-122
32909857-11	2021	Furthermore, ROS is involved in the COX-1 and COX-2 up-regulations of renal arteries, maybe serving as a mediator in the inhibitory action of calcitriol on COX expression.	Calcitriol	142-152	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
32909857-10	2021	Taken together, our findings showed that COX-1 and COX-2 are positively involved in the renovascular dysfunction in hypertension and via VDR, calcitriol benefits renovasular function by suppressing COX-1 and COX-2 expressions.	Calcitriol	142-152	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-56
32814135-5	2021	Based on the characterization results, the sulfate radicals and hydroxyl radicals were considered to be the main free radicals which were involved into the circulation of Co(II)-Co(III)-Co(II) as well as the oxidation of  Fe(II), which was responsible for the remarkable catalytic efficiency.	sulfate radical	43-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	171-177
33015829-0	2021	Design and synthesis of pyrazole-pyrazoline hybrids as cancer-associated selective COX-2 inhibitors.	pyrazole	24-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
33015829-0	2021	Design and synthesis of pyrazole-pyrazoline hybrids as cancer-associated selective COX-2 inhibitors.	pyrazoline	33-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
33250206-3	2021	This study aimed to evaluate the inhibitory activity of new derivatives against both cyclooxygenase isoforms COX-1 and COX-2 due to the similarity of new compounds to oxicams drugs from the NSAIDs group.	oxicams drugs	167-180	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-124
33520284-9	2021	The title compound is isotypic with its CoII and MnII analogues: the three K2 M 3(OH)2(SO4)3(H2O)2 (M = Mg, Co, Mn) structures are qu-anti-tatively compared.	3(oh)2(so4)3	80-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-44
33520284-9	2021	The title compound is isotypic with its CoII and MnII analogues: the three K2 M 3(OH)2(SO4)3(H2O)2 (M = Mg, Co, Mn) structures are qu-anti-tatively compared.	Water	93-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-44
31899683-9	2021	As like, flavanone derivatives HFAc (7-hydroxy-2-(4-hydroxy-3-methoxy phenyl)-2,3-dihydro-4H-chromen-4-one), HFAb (7-hydroxy-2-(4-methoxy phenyl)-2,3-dihydro-4H-chromen-4-one) and HFAd (7-hydroxy-2-(thiophen-2-yl)-2,3-dihydro-4H-chromen-4-one) showed significant anti-inflammatory activity compared to the standard COX-2 inhibitors.	Flavanones	9-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	315-320
32814135-5	2021	Based on the characterization results, the sulfate radicals and hydroxyl radicals were considered to be the main free radicals which were involved into the circulation of Co(II)-Co(III)-Co(II) as well as the oxidation of  Fe(II), which was responsible for the remarkable catalytic efficiency.	sulfate radical	43-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	186-192
32814135-5	2021	Based on the characterization results, the sulfate radicals and hydroxyl radicals were considered to be the main free radicals which were involved into the circulation of Co(II)-Co(III)-Co(II) as well as the oxidation of  Fe(II), which was responsible for the remarkable catalytic efficiency.	Hydroxyl Radical	64-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	171-177
32814135-5	2021	Based on the characterization results, the sulfate radicals and hydroxyl radicals were considered to be the main free radicals which were involved into the circulation of Co(II)-Co(III)-Co(II) as well as the oxidation of  Fe(II), which was responsible for the remarkable catalytic efficiency.	Hydroxyl Radical	64-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	186-192
32814135-5	2021	Based on the characterization results, the sulfate radicals and hydroxyl radicals were considered to be the main free radicals which were involved into the circulation of Co(II)-Co(III)-Co(II) as well as the oxidation of  Fe(II), which was responsible for the remarkable catalytic efficiency.	co(iii)	178-185	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	171-177
32814135-5	2021	Based on the characterization results, the sulfate radicals and hydroxyl radicals were considered to be the main free radicals which were involved into the circulation of Co(II)-Co(III)-Co(II) as well as the oxidation of  Fe(II), which was responsible for the remarkable catalytic efficiency.	co(iii)	178-185	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	186-192
32814135-5	2021	Based on the characterization results, the sulfate radicals and hydroxyl radicals were considered to be the main free radicals which were involved into the circulation of Co(II)-Co(III)-Co(II) as well as the oxidation of  Fe(II), which was responsible for the remarkable catalytic efficiency.	ammonium ferrous sulfate	222-228	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	171-177
33129592-7	2021	The highest COX-1 selectivity was exhibited by the compound in which the spacer was the benzidine [N,N"-(biphenyl-4,4"-di-yl)bis (2-[3,4-bis(4-methoxyphenyl)isoxazol-5-yl]acetamide) (15): COX-1 IC50 = 0.08 muM, COX-2 IC50 > 50 muM, Selectivity Index (SI) > 625].	benzidine	88-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	211-216
32862342-0	2021	Preparation of graphene oxide-modified palygorskite nanocomposites for high-efficient removal of Co(II) from wastewater.	graphene oxide	15-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-103
32862342-0	2021	Preparation of graphene oxide-modified palygorskite nanocomposites for high-efficient removal of Co(II) from wastewater.	attapulgite	39-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-103
32862342-2	2021	In the work, the nanocomposite of graphene oxide-modified palygorskite (mPal-GO) is synthesized by cross-linking one-dimensional palygorskite (Pal) with two-dimensional material graphene oxide (GO), and used to remove Co(II) from wastewater.	graphene oxide	34-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	218-224
32862342-2	2021	In the work, the nanocomposite of graphene oxide-modified palygorskite (mPal-GO) is synthesized by cross-linking one-dimensional palygorskite (Pal) with two-dimensional material graphene oxide (GO), and used to remove Co(II) from wastewater.	graphene oxide	77-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	218-224
33071054-0	2021	Design, synthesis and biological assessment of new selective COX-2 inhibitors including methyl sulfonyl moiety.	methyl sulfonyl	88-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-66
33071054-4	2021	The design, synthesis and biological activity evaluation of novel derivatives bearing thiazolylhydrazine-methyl sulfonyl moiety as selective COX-2 inhibitors were aimed in this paper.	thiazolylhydrazine	86-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	141-146
33071054-4	2021	The design, synthesis and biological activity evaluation of novel derivatives bearing thiazolylhydrazine-methyl sulfonyl moiety as selective COX-2 inhibitors were aimed in this paper.	methyl sulfonyl	105-120	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	141-146
33129592-7	2021	The highest COX-1 selectivity was exhibited by the compound in which the spacer was the benzidine [N,N"-(biphenyl-4,4"-di-yl)bis (2-[3,4-bis(4-methoxyphenyl)isoxazol-5-yl]acetamide) (15): COX-1 IC50 = 0.08 muM, COX-2 IC50 > 50 muM, Selectivity Index (SI) > 625].	n,n"-(biphenyl-4,4"-di-yl)bis (2-[3,4-bis(4-methoxyphenyl)isoxazol-5-yl]acetamide)	99-181	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	211-216
33211383-11	2021	Besides, maltol not only suppressed the production of COX-2, iNOs, TNF-alpha, IL-6, ADAMTS-5, MMP-13, but also attenuated the degradation of collagen II and aggrecan.	maltol	9-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-59
33136175-9	2021	LTD4 also enhanced inflammation by increasing the expression of COX-2 in SAECs.	Leukotriene D4	0-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-69
33416107-9	2021	It was demonstrated that AdC inhibited COX2 methylation and downregulated COX2 expression.	Decitabine	25-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-43
33416107-9	2021	It was demonstrated that AdC inhibited COX2 methylation and downregulated COX2 expression.	Decitabine	25-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-78
33076095-1	2021	Preconcentration of Cd(II), Co(II), Cu(II), Ni(II), Pb(II), and Zn(II) in aqueous biphasic system tetrabutylammonium bromide (TBAB) - H2O - (NH4)2SO4 followed by ICP-OES determination is reported for the first time.	tetrabutylammonium	98-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-34
33070080-17	2021	The inhibition of the STAT1/COX-2/iNOS signaling pathway by apigenin is an important mechanism not only in the suppression of inflammation but also in induction of apoptosis.	Apigenin	60-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
33408498-7	2020	Significant hazard of disease progression was associated with smoking (HR=1.27, P=0.004), 5-FU induction of COX2, and IL6 expression (HR=1.35, P=0.001 and HR=1.27, P=0.004, respectively).	Fluorouracil	90-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-112
33216331-6	2021	The expression of COX-2 and cyclin B levels decreased by 36% and 52% respectively, after treatment with 0.5 mg/mL paracetamol.	Acetaminophen	114-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-23
33408498-6	2020	DFS and OS rates were reduced in patients with increased COX2, IL6, IL10, and TNFalpha expression with 5-FU therapy.	Fluorouracil	103-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-61
33458549-4	2021	The effect of different factors on adsorption properties of the Fe3O4@S-S/PMAA nanoparticles for Co(II) and Pb(II) ions in aqueous solution was explored by batch adsorption experiments.	ferryl iron	64-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-103
33383842-5	2020	The results disclosed compounds 7, 13, 25 and sclerotiorin showed moderate to good COX-2 inhibition with the inhibitory ratios of 58.7%, 51.1%, 66.1% and 56.1%, respectively.	sclerotiorin	46-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
33383842-7	2020	Furthermore, molecular docking was used to rationalize the potential of the sclerotiorin derivatives as COX2 inhibitory agents by predicting their binding energy, binding modes and optimal orientation at the active site of the COX-2.	sclerotiorin	76-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-108
33383842-7	2020	Furthermore, molecular docking was used to rationalize the potential of the sclerotiorin derivatives as COX2 inhibitory agents by predicting their binding energy, binding modes and optimal orientation at the active site of the COX-2.	sclerotiorin	76-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	227-232
33458549-4	2021	The effect of different factors on adsorption properties of the Fe3O4@S-S/PMAA nanoparticles for Co(II) and Pb(II) ions in aqueous solution was explored by batch adsorption experiments.	polymethacrylic acid	74-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-103
33458549-5	2021	For adsorption mechanism investigation, the adsorption of Fe3O4@S-S/PMAA for Co(II) and Pb(II) ions can be better fitted by a pseudo-second-order model, and the adsorption process of Fe3O4@S-S/PMAA for Co(II) and Pb(II) matches well with the Freundlich isotherm equation.	ferryl iron	58-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-83
33458549-5	2021	For adsorption mechanism investigation, the adsorption of Fe3O4@S-S/PMAA for Co(II) and Pb(II) ions can be better fitted by a pseudo-second-order model, and the adsorption process of Fe3O4@S-S/PMAA for Co(II) and Pb(II) matches well with the Freundlich isotherm equation.	ferryl iron	58-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	202-208
33458549-5	2021	For adsorption mechanism investigation, the adsorption of Fe3O4@S-S/PMAA for Co(II) and Pb(II) ions can be better fitted by a pseudo-second-order model, and the adsorption process of Fe3O4@S-S/PMAA for Co(II) and Pb(II) matches well with the Freundlich isotherm equation.	polymethacrylic acid	68-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-83
33458549-5	2021	For adsorption mechanism investigation, the adsorption of Fe3O4@S-S/PMAA for Co(II) and Pb(II) ions can be better fitted by a pseudo-second-order model, and the adsorption process of Fe3O4@S-S/PMAA for Co(II) and Pb(II) matches well with the Freundlich isotherm equation.	polymethacrylic acid	68-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	202-208
33458549-5	2021	For adsorption mechanism investigation, the adsorption of Fe3O4@S-S/PMAA for Co(II) and Pb(II) ions can be better fitted by a pseudo-second-order model, and the adsorption process of Fe3O4@S-S/PMAA for Co(II) and Pb(II) matches well with the Freundlich isotherm equation.	ferryl iron	183-188	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-83
33458549-5	2021	For adsorption mechanism investigation, the adsorption of Fe3O4@S-S/PMAA for Co(II) and Pb(II) ions can be better fitted by a pseudo-second-order model, and the adsorption process of Fe3O4@S-S/PMAA for Co(II) and Pb(II) matches well with the Freundlich isotherm equation.	ferryl iron	183-188	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	202-208
33458549-5	2021	For adsorption mechanism investigation, the adsorption of Fe3O4@S-S/PMAA for Co(II) and Pb(II) ions can be better fitted by a pseudo-second-order model, and the adsorption process of Fe3O4@S-S/PMAA for Co(II) and Pb(II) matches well with the Freundlich isotherm equation.	polymethacrylic acid	193-197	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-83
33458549-7	2021	In the regeneration experiments, the Fe3O4@S-S/PMAA nanoparticles could be easily recovered by desorbing heavy metal ions from the adsorbents with eluents and showed good adsorption capacity for Co(II) and Pb(II) after eight recycles.	ferryl iron	37-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	195-201
33458549-7	2021	In the regeneration experiments, the Fe3O4@S-S/PMAA nanoparticles could be easily recovered by desorbing heavy metal ions from the adsorbents with eluents and showed good adsorption capacity for Co(II) and Pb(II) after eight recycles.	polymethacrylic acid	47-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	195-201
33458549-7	2021	In the regeneration experiments, the Fe3O4@S-S/PMAA nanoparticles could be easily recovered by desorbing heavy metal ions from the adsorbents with eluents and showed good adsorption capacity for Co(II) and Pb(II) after eight recycles.	Metals	111-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	195-201
33374505-6	2020	Our results demonstrated that 4-PSB-2 can decrease the elevated expressions of TNF-alpha, COX-2, and iNOS via NF-kappaB signaling in ARPE-19 cells treated with oAbeta1-42 without causing any cytotoxicity or notable side effects.	4-(phenylsulfanyl)butan-2-one	30-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-95
32846348-3	2020	However, the loadings of Co(II) at 0.024-0.03 kgCo2+added/(m3.d) negatively affected the activity of MAB.	kgco2+	46-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-31
33458464-12	2021	The upregulated COX-2, TLR2, MyD-88, and NF-kappaB in the LPS-treated macrophages were significantly downregulated by azilsartan.	azilsartan	118-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-21
33348929-0	2020	Pertraction of Co(II) through Novel Ultrasound Prepared Supported Liquid Membranes Containing D2EHPA.	d2ehpa	94-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-21
32846348-6	2020	The nitrogen removal with Co(II) addition could be well described by a modified Logistic model.	Nitrogen	4-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-32
32836125-0	2020	Electro-assisted adsorption of Cs(I) and Co(II) from aqueous solution by capacitive deionization with activated carbon cloth/graphene oxide composite electrode.	Carbon	112-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-47
32836125-0	2020	Electro-assisted adsorption of Cs(I) and Co(II) from aqueous solution by capacitive deionization with activated carbon cloth/graphene oxide composite electrode.	graphene oxide	125-139	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-47
32846348-0	2020	Biostimulation of a marine anammox bacteria-dominated bioprocess by Co(II) to treat nitrogen-rich, saline wastewater.	Nitrogen	84-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-74
32846348-0	2020	Biostimulation of a marine anammox bacteria-dominated bioprocess by Co(II) to treat nitrogen-rich, saline wastewater.	Sodium Chloride	99-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-74
33348929-2	2020	Pertraction of Co(II) through novel supported liquid membranes prepared by ultrasound, using bis-2-ethylhexyl phosphoric acid as carrier, sulfuric acid as stripping agent and a counter-transport mechanism, is studied in this paper.	bis-2-ethylhexyl phosphoric acid	93-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-21
33348757-0	2020	Design, Synthesis and Comprehensive Investigations of Pyrrolo[3,4-d]pyridazinone-Based 1,3,4-Oxadiazole as New Class of Selective COX-2 Inhibitors.	pyrrolo(3,4-d)pyridazinone	54-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	130-135
33348929-2	2020	Pertraction of Co(II) through novel supported liquid membranes prepared by ultrasound, using bis-2-ethylhexyl phosphoric acid as carrier, sulfuric acid as stripping agent and a counter-transport mechanism, is studied in this paper.	sulfuric acid	138-151	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-21
33348757-0	2020	Design, Synthesis and Comprehensive Investigations of Pyrrolo[3,4-d]pyridazinone-Based 1,3,4-Oxadiazole as New Class of Selective COX-2 Inhibitors.	1,3,4-oxadiazole	87-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	130-135
33225679-7	2020	Our data demonstrate that furosemide inhibits the secretion of proinflammatory TNF-alpha, IL-6, and nitric oxide; downregulates the mRNA level of Cd86 and the protein expression of COX-2, iNOS; promotes phagocytic activity; and enhances the expression of anti-inflammatory IL-1RA and arginase.	Furosemide	26-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	181-186
33348757-3	2020	Previously, we have reported the Mannich base-type derivatives of pyrrolo[3,4-d]pyridazinone which strongly inhibit cyclooxygenase, have better affinity to COX-2 isoenzyme and exert promising anti-oxidant activity.	pyrrolo(3,4-d)pyridazinone	66-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	156-161
33348757-8	2020	These findings stay in good correlation with molecular modeling results, which additionally showed that investigated compounds take a position in the active site of COX-2 very similar to Meloxicam.	Meloxicam	187-196	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	165-170
32830352-2	2020	In this article, we report Co(II, III) as an electrochemical catalyst in the sulfur cathode that renders a reduced discharge-charge voltage hysteresis and improved capacity retention and rate capability for Al-S batteries.	sulfur cathode	77-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-37
33225681-2	2020	However, in this study, it was surprisingly found that methyl phenyl sulfoxide (PMSO) was readily oxidized to the corresponding sulfone (PMSO2) with a transformation ratio of ~100% under acidic conditions, which strongly implied the generation of high-valent cobalt-oxo species [Co(IV)] instead of SO4 - in the Co(II)/PMS process.	methyl phenyl sulfoxide	55-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	311-317
33225681-2	2020	However, in this study, it was surprisingly found that methyl phenyl sulfoxide (PMSO) was readily oxidized to the corresponding sulfone (PMSO2) with a transformation ratio of ~100% under acidic conditions, which strongly implied the generation of high-valent cobalt-oxo species [Co(IV)] instead of SO4 - in the Co(II)/PMS process.	pmso	80-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	311-317
33225681-2	2020	However, in this study, it was surprisingly found that methyl phenyl sulfoxide (PMSO) was readily oxidized to the corresponding sulfone (PMSO2) with a transformation ratio of ~100% under acidic conditions, which strongly implied the generation of high-valent cobalt-oxo species [Co(IV)] instead of SO4 - in the Co(II)/PMS process.	Sulfones	128-135	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	311-317
33225681-2	2020	However, in this study, it was surprisingly found that methyl phenyl sulfoxide (PMSO) was readily oxidized to the corresponding sulfone (PMSO2) with a transformation ratio of ~100% under acidic conditions, which strongly implied the generation of high-valent cobalt-oxo species [Co(IV)] instead of SO4 - in the Co(II)/PMS process.	pmso2	137-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	311-317
33225681-2	2020	However, in this study, it was surprisingly found that methyl phenyl sulfoxide (PMSO) was readily oxidized to the corresponding sulfone (PMSO2) with a transformation ratio of ~100% under acidic conditions, which strongly implied the generation of high-valent cobalt-oxo species [Co(IV)] instead of SO4 - in the Co(II)/PMS process.	peroxymonosulfate	80-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	311-317
33225681-5	2020	Density functional theory calculation determined that the formation of Co(IV) was thermodynamically favorable than that of SO4 - and  OH in the Co(II)/PMS process.	co(iv)	71-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	144-150
33225681-5	2020	Density functional theory calculation determined that the formation of Co(IV) was thermodynamically favorable than that of SO4 - and  OH in the Co(II)/PMS process.	so4 -	123-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	144-150
33225681-5	2020	Density functional theory calculation determined that the formation of Co(IV) was thermodynamically favorable than that of SO4 - and  OH in the Co(II)/PMS process.	peroxymonosulfate	151-154	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	144-150
33225681-7	2020	Additionally, the degradation intermediates of sulfamethoxazole (SMX) in the Co(II)/PMS process under acidic conditions were identified to further understand the interaction between Co(IV) and the representative contaminant.	Sulfamethoxazole	47-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-83
33225681-7	2020	Additionally, the degradation intermediates of sulfamethoxazole (SMX) in the Co(II)/PMS process under acidic conditions were identified to further understand the interaction between Co(IV) and the representative contaminant.	Sulfamethoxazole	65-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-83
33225681-7	2020	Additionally, the degradation intermediates of sulfamethoxazole (SMX) in the Co(II)/PMS process under acidic conditions were identified to further understand the interaction between Co(IV) and the representative contaminant.	peroxymonosulfate	84-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-83
33225681-7	2020	Additionally, the degradation intermediates of sulfamethoxazole (SMX) in the Co(II)/PMS process under acidic conditions were identified to further understand the interaction between Co(IV) and the representative contaminant.	co(iv)	182-188	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-83
32830352-2	2020	In this article, we report Co(II, III) as an electrochemical catalyst in the sulfur cathode that renders a reduced discharge-charge voltage hysteresis and improved capacity retention and rate capability for Al-S batteries.	Aluminum	207-209	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-37
32830352-2	2020	In this article, we report Co(II, III) as an electrochemical catalyst in the sulfur cathode that renders a reduced discharge-charge voltage hysteresis and improved capacity retention and rate capability for Al-S batteries.	Sulfur	210-211	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-37
32830352-3	2020	The structural and electrochemical analysis suggest that the catalytic effect of Co(II, III) is closely associated with the formation of cobalt sulfides and the changes in the valence states of the Co(II,III) during the electrochemical reactions of the sulfur species, which lead to improved reaction kinetics and sulfur utilization in the cathode.	cobaltous sulfide	137-152	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-91
32830352-3	2020	The structural and electrochemical analysis suggest that the catalytic effect of Co(II, III) is closely associated with the formation of cobalt sulfides and the changes in the valence states of the Co(II,III) during the electrochemical reactions of the sulfur species, which lead to improved reaction kinetics and sulfur utilization in the cathode.	co(ii,iii)	198-208	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-91
32830352-3	2020	The structural and electrochemical analysis suggest that the catalytic effect of Co(II, III) is closely associated with the formation of cobalt sulfides and the changes in the valence states of the Co(II,III) during the electrochemical reactions of the sulfur species, which lead to improved reaction kinetics and sulfur utilization in the cathode.	Sulfur	253-259	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-91
32830352-3	2020	The structural and electrochemical analysis suggest that the catalytic effect of Co(II, III) is closely associated with the formation of cobalt sulfides and the changes in the valence states of the Co(II,III) during the electrochemical reactions of the sulfur species, which lead to improved reaction kinetics and sulfur utilization in the cathode.	Sulfur	314-320	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-91
33292158-7	2021	Additionally, the PGE2 concentration in hypothalamus was quantified by ELISA and the inhibitory effect of N-cyclopentyl-N"-[3-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)phenyl]ethanediamide (1) over human COX-2 enzymatic activity was determined with a COX Colorimetric Inhibitor Screening Assay Kit.	n-cyclopentyl-n"-[3-(3-cyclopropyl-1h-1,2,4-triazol-5-yl)phenyl]ethanediamide	106-183	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	199-204
33333798-1	2020	In this paper, the effect of the scalability of small-scale devices on the separation of Co(II) from a binary Co(II)/Ni(II) mixture in a nitric acid solution by an organic Cyanex 272/TBP/kerosene (Exxsol D80) phase is studied.	Cobalt(2+)	89-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-116
33180075-0	2020	Slow magnetization relaxation in a tetrahedrally coordinated mononuclear Co(II) complex exclusively ligated with phenanthroline ligands.	Phenanthrolines	113-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-79
33180075-1	2020	This paper describes a tetrahedral mononuclear Co(ii) complex [CoL2](ClO4)2 (1) in which L = 2,9-diphenyl-1,10-phenanthroline.	[col2](clo4)2	62-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-53
33091445-8	2020	Pretreatment with piperine suppressed the activation of phosphorylated p38, JNK, and AP-1 as well as the levels of COX-2/PGE2 and iNOS synthesis, while UV-B-irradiated cells triggered the induction of these signaling molecules.	piperine	18-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-120
33238707-4	2020	We herein report a catalytic approach that is highly effective for controlling enantioselectivity as well as reactivity of the intermolecular radical C-H amination of carboxylic acid esters with organic azides via Co(II)-based metalloradical catalysis (MRC).	carboxylic acid esters	167-189	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	214-220
33238707-4	2020	We herein report a catalytic approach that is highly effective for controlling enantioselectivity as well as reactivity of the intermolecular radical C-H amination of carboxylic acid esters with organic azides via Co(II)-based metalloradical catalysis (MRC).	Azides	203-209	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	214-220
33179662-0	2020	Water soluble ionic Co(II), Cu(II) and Zn(II) diimine-glycinate complexes targeted to tRNA: structural description, in vitro comparative binding, cleavage and cytotoxic studies towards chemoresistant prostate cancer cells.	Water	0-5	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-26
33179662-0	2020	Water soluble ionic Co(II), Cu(II) and Zn(II) diimine-glycinate complexes targeted to tRNA: structural description, in vitro comparative binding, cleavage and cytotoxic studies towards chemoresistant prostate cancer cells.	Water	0-5	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-25
33179662-1	2020	Four new water soluble Co(ii), Cu(ii) and Zn(ii) ionic metal complexes (1-4) [Cu(diimine)(H2O)2(glycinate)]+[glycinate]-, [Co(diimine)(H2O)4]+[glycinate]- and [Zn(diimine) (H2O)4]+[glycinate]-, where diimine = 2,2"-bipyridine (1-3) and 1,10-phenanthroline (4) were synthesized and thoroughly characterized by spectroscopic and single X-ray crystallographic studies.	Water	9-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-29
33179662-1	2020	Four new water soluble Co(ii), Cu(ii) and Zn(ii) ionic metal complexes (1-4) [Cu(diimine)(H2O)2(glycinate)]+[glycinate]-, [Co(diimine)(H2O)4]+[glycinate]- and [Zn(diimine) (H2O)4]+[glycinate]-, where diimine = 2,2"-bipyridine (1-3) and 1,10-phenanthroline (4) were synthesized and thoroughly characterized by spectroscopic and single X-ray crystallographic studies.	Water	9-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-28
33180075-1	2020	This paper describes a tetrahedral mononuclear Co(ii) complex [CoL2](ClO4)2 (1) in which L = 2,9-diphenyl-1,10-phenanthroline.	2,9-diphenyl-1,10-phenanthroline	93-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-53
33293599-5	2020	Platelet-derived TXA2 induced COX-2 and enhanced prostaglandin (PG)E2 biosynthesis in CASMC, a known mechanism promoting neointimal hyperplasia.	Thromboxane A2	17-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-35
33180075-5	2020	This study describes a very rare case of a Co(ii) single ion magnet (SIM) that is purely tetrahedrally coordinated by pyridine like ligands.	pyridine	118-126	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-49
33191419-0	2020	Field-induced slow magnetic relaxation from linear trinuclear CoIII-CoII-CoIII to grid [2 x 2] tetranuclear mixed-valence cobalt complexes.	Cobalt	122-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-66
33179662-1	2020	Four new water soluble Co(ii), Cu(ii) and Zn(ii) ionic metal complexes (1-4) [Cu(diimine)(H2O)2(glycinate)]+[glycinate]-, [Co(diimine)(H2O)4]+[glycinate]- and [Zn(diimine) (H2O)4]+[glycinate]-, where diimine = 2,2"-bipyridine (1-3) and 1,10-phenanthroline (4) were synthesized and thoroughly characterized by spectroscopic and single X-ray crystallographic studies.	Water	90-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-29
33376898-7	2020	In addition, among these compounds, those with hydrogen at the 4"-position (2a and 2c) selectively inhibited the COX-2 enzyme.	Hydrogen	47-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-118
33293599-6	2020	COX-2 induction was prevented by different antiplatelet agents, i.e., Aspirin, the TP antagonist SQ29,548, or Revacept (a dimeric soluble GPVI-Fc fusion protein).	Aspirin	70-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
33293599-6	2020	COX-2 induction was prevented by different antiplatelet agents, i.e., Aspirin, the TP antagonist SQ29,548, or Revacept (a dimeric soluble GPVI-Fc fusion protein).	sq29,548	97-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
33270831-9	2020	In mechanism, miR-26b-5p targeted COX2 and decreased its expression, leading to significant decreases in the levels of PGE2, TNF-alpha and IL-6 in RAOEC and HMEC-1 cells.	Dinoprostone	119-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-38
32947702-7	2020	Mechanism investigation suggested that the oxygen vacancies, redox cycles of Co(II)/Co(III) and S22-/(S2- and sulfate species) on the surface of 0.2CoAl-LDH@CoSx were crucial for PMS activation.	Oxygen	43-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-83
32947702-7	2020	Mechanism investigation suggested that the oxygen vacancies, redox cycles of Co(II)/Co(III) and S22-/(S2- and sulfate species) on the surface of 0.2CoAl-LDH@CoSx were crucial for PMS activation.	co(iii)	84-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-83
32947702-7	2020	Mechanism investigation suggested that the oxygen vacancies, redox cycles of Co(II)/Co(III) and S22-/(S2- and sulfate species) on the surface of 0.2CoAl-LDH@CoSx were crucial for PMS activation.	Sulfates	110-117	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-83
32947702-7	2020	Mechanism investigation suggested that the oxygen vacancies, redox cycles of Co(II)/Co(III) and S22-/(S2- and sulfate species) on the surface of 0.2CoAl-LDH@CoSx were crucial for PMS activation.	cosx	157-161	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-83
33270831-11	2020	In conclusion, this study revealed that HDBD relieved acute STI via modulating miR-26b-5p/COX2 axis to inhibit inflammation.	hdbd	40-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-94
32966814-1	2020	AR12 is a derivative of celecoxib which no-longer acts against COX2 but instead inhibits the ATPase activity of multiple chaperone proteins, in particular GRP78.	Celecoxib	24-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-67
32931773-7	2020	Consistent with these results, CyM diminished the expression of inflammatory genes (COX-2, TNF-alpha, IL-1beta, and IL-6), AP-1-Luc activity, and phosphorylation of Ras-mediated signaling enzymes in Ras-overexpressing HEK 293 cells.	cysmethynil	31-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-89
33166844-0	2020	Synthesis of novel halogenated triarylpyrazoles as selective COX-2 inhibitors: Anti-inflammatory activity, histopatholgical profile and in-silico studies.	halogenated triarylpyrazoles	19-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-66
33132165-8	2020	Finally, we showed that PNU-120596 suppressed LPS-induced phosphorylation of p38 MAPK and expression of inflammatory factors including TNF-alpha, IL-6 and COX-2, independent on alpha7 nAChR activity in microglial cell BV-2.	1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea	24-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	155-160
33166844-2	2020	All target compounds showed good in vitro COX-2 inhibitory activity (IC50 = 0.043-0.17 microM) over COX-1 (IC50 = 7.8 - 15.4 microM) relative to celecoxib (COX-1/IC50 = 9.87, COX-2/IC50 = 0.055), with acceptable selectivity index values (SI = 50.6-253.1).	Celecoxib	145-154	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47
33166844-4	2020	Three fluorinated pyrazoles 12a, 12g and 12j, exhibited superior anti-inflammatory activity at all time intervals (% edema inhibition = 42.1-87.9) with better gastric profile (UI = 1.25-2.5) than the traditional NSAID; indomethacin (UI = 14) and were close to the selective COX-2 inhibitor; celecoxib (UI = 1.75).	fluorinated	6-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	274-279
33166844-4	2020	Three fluorinated pyrazoles 12a, 12g and 12j, exhibited superior anti-inflammatory activity at all time intervals (% edema inhibition = 42.1-87.9) with better gastric profile (UI = 1.25-2.5) than the traditional NSAID; indomethacin (UI = 14) and were close to the selective COX-2 inhibitor; celecoxib (UI = 1.75).	Pyrazoles	18-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	274-279
32853608-3	2020	Herein, the development of a novel bead-like adsorbent with above features, that is, Al(III)-assembled carboxymethyl cellulose beads were used for the removal of Pb(II), Ni(II) and Co(II) from aqueous solution.	al(iii)	85-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	181-187
32683014-6	2020	It shows strong affinity towards Au(III) in the mixture solutions containing Au(III), Cu(II), Zn(II), Co(II), Cd(II), Pb(II) and Ni(II) ions.	Gold	33-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-108
32683014-6	2020	It shows strong affinity towards Au(III) in the mixture solutions containing Au(III), Cu(II), Zn(II), Co(II), Cd(II), Pb(II) and Ni(II) ions.	au(iii)	33-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-108
32853608-3	2020	Herein, the development of a novel bead-like adsorbent with above features, that is, Al(III)-assembled carboxymethyl cellulose beads were used for the removal of Pb(II), Ni(II) and Co(II) from aqueous solution.	Carboxymethylcellulose Sodium	103-126	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	181-187
32853608-3	2020	Herein, the development of a novel bead-like adsorbent with above features, that is, Al(III)-assembled carboxymethyl cellulose beads were used for the removal of Pb(II), Ni(II) and Co(II) from aqueous solution.	pb(ii)	162-168	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	181-187
32853608-8	2020	The adsorption isotherm could be described well by the Freundlich model, and the maximum adsorption capacity for Pb(II), Ni(II) and Co(II) were 550, 620 and 760 mg/g, respectively.	pb(ii)	113-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-138
32013633-6	2020	Cyclic imides bearing 3-benzenesulfonamide (2-5, and 9), acetophenone oxime (11-14, 18, and 19) exhibited high selectivity against COX-2 with SI > 55.6-333.3 relative to that for celecoxib [SI > 387.6].	cyclic imides	0-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-136
33096361-4	2020	In in-vitro experiments, the protective effect of aloin on the anabolism and catabolism of the extracellular matrix (ECM) induced by IL-1 beta in chondrocytes by inhibiting the expression of pro-inflammatory factors, including TNF-alpha (p = 0.016), IL-6 (p = 0.006), iNOS (p = 0.001) and COX-2 (p = 0.006).	alloin	50-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	289-294
32183576-7	2020	The molecular docking of compounds 4b and 13 with the COX-2 and PDE4B binding pockets was studied.HighlightsAntitumor activity of new synthesized cyclopentyloxyanisole scaffold was evaluated.The powerful antitumor 4a, 4b, 6b, 7b & 13 were assessed as COX-2, PDE4B & TNF-alpha inhibitors.Compounds 4a, 7b, and 13 exhibited COX-2, PDE4B, and TNF-alpha inhibition.Compounds 4b and 13 showed strong interactions at the COX-2 and PDE4B binding pockets.	cyclopentyloxyanisole	146-167	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	251-256
32183576-7	2020	The molecular docking of compounds 4b and 13 with the COX-2 and PDE4B binding pockets was studied.HighlightsAntitumor activity of new synthesized cyclopentyloxyanisole scaffold was evaluated.The powerful antitumor 4a, 4b, 6b, 7b & 13 were assessed as COX-2, PDE4B & TNF-alpha inhibitors.Compounds 4a, 7b, and 13 exhibited COX-2, PDE4B, and TNF-alpha inhibition.Compounds 4b and 13 showed strong interactions at the COX-2 and PDE4B binding pockets.	cyclopentyloxyanisole	146-167	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	251-256
32183576-7	2020	The molecular docking of compounds 4b and 13 with the COX-2 and PDE4B binding pockets was studied.HighlightsAntitumor activity of new synthesized cyclopentyloxyanisole scaffold was evaluated.The powerful antitumor 4a, 4b, 6b, 7b & 13 were assessed as COX-2, PDE4B & TNF-alpha inhibitors.Compounds 4a, 7b, and 13 exhibited COX-2, PDE4B, and TNF-alpha inhibition.Compounds 4b and 13 showed strong interactions at the COX-2 and PDE4B binding pockets.	cyclopentyloxyanisole	146-167	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	251-256
32200655-5	2020	However, this concentration of Ibu-AM68 greatly reduced the ability of the COX-2 to catalyse the cyclooxygenation of the endocannabinoid 2-arachidonoylglycerol.	ibu-am68	31-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
32200655-5	2020	However, this concentration of Ibu-AM68 greatly reduced the ability of the COX-2 to catalyse the cyclooxygenation of the endocannabinoid 2-arachidonoylglycerol.	Endocannabinoids	121-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
32200655-5	2020	However, this concentration of Ibu-AM68 greatly reduced the ability of the COX-2 to catalyse the cyclooxygenation of the endocannabinoid 2-arachidonoylglycerol.	glyceryl 2-arachidonate	137-159	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
32238055-0	2020	Novel sulindac derivatives: synthesis, characterisation, evaluation of antioxidant, analgesic, anti-inflammatory, ulcerogenic and COX-2 inhibition activity.	Sulindac	6-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	130-135
32013633-6	2020	Cyclic imides bearing 3-benzenesulfonamide (2-5, and 9), acetophenone oxime (11-14, 18, and 19) exhibited high selectivity against COX-2 with SI > 55.6-333.3 relative to that for celecoxib [SI > 387.6].	3-benzenesulfonamide	22-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-136
32238055-10	2020	The animals treated with compound 3 prior to cisplatin treatment resulted in a significant reduction in COX-2 protein expression when compared to cisplatin-treated group.	Cisplatin	45-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
32013633-6	2020	Cyclic imides bearing 3-benzenesulfonamide (2-5, and 9), acetophenone oxime (11-14, 18, and 19) exhibited high selectivity against COX-2 with SI > 55.6-333.3 relative to that for celecoxib [SI > 387.6].	Acetophenone oxime	57-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-136
32781854-7	2020	Moreover, KM6 reduced the levels of inflammation markers PGE2, COX2, IL-1beta and IL6 and metastasis markers MMP-2 and MMP-9.	km6	10-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-67
32013633-6	2020	Cyclic imides bearing 3-benzenesulfonamide (2-5, and 9), acetophenone oxime (11-14, 18, and 19) exhibited high selectivity against COX-2 with SI > 55.6-333.3 relative to that for celecoxib [SI > 387.6].	Celecoxib	179-188	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-136
33045593-5	2020	Accordingly, in this study we have synthesized and characterized two new Co(II) complexes with thiocarbamoyl-pyrazoline ligands to assess their antimicrobial, mutagenic, and cytotoxic potential.	thiocarbamoyl pyrazoline	95-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-79
33126082-7	2020	The role of p300 HAT was confirmed by using C646, an inhibitor of p300, that reduced binding of acetylated H3 and H4 histones at the COX2 promoter, COX2 transcription, and PGE2 production in monocytes.	C646	44-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	133-137
32989835-2	2020	The COX-2 inhibitor etoricoxib, in particular, was studied.	Etoricoxib	20-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
33126082-7	2020	The role of p300 HAT was confirmed by using C646, an inhibitor of p300, that reduced binding of acetylated H3 and H4 histones at the COX2 promoter, COX2 transcription, and PGE2 production in monocytes.	C646	44-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	148-152
33007445-5	2020	The effects of 15(S)-HETE on COX-2 expression and prostaglandin (PG) production were analyzed by immunoblotting and specific enzyme immunoassays.	Icomucret	15-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34
33007445-6	2020	The addition of 15(S)-HETE resulted in elevated levels of COX-2 expression and PG production.	Icomucret	16-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
32920160-1	2020	BACKGROUND: Cyclooxygenase-2(COX-2) is a key enzyme in the synthesis of prostaglandins.	Prostaglandins	72-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34
33266208-7	2020	Strong COX-2 inhibitory activity was observed after the use of TG6 and, especially, TG4.	2-(Butylamino)-~{n}-[2-(4-Sulfamoylphenyl)ethyl]ethanamide	84-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	7-12
33266208-8	2020	The TG11 compound, as well as reference meloxicam, turned out to be a preferential COX-2 inhibitor.	tg11	4-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
33266208-8	2020	The TG11 compound, as well as reference meloxicam, turned out to be a preferential COX-2 inhibitor.	Meloxicam	40-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
32186563-7	2020	A possible weak interaction between one of the chlorides and the carbenium moiety in the ligand is observed in crystals of both of the Co(ii) and Ni(ii) complexes with ligand L1.	Chlorides	47-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-141
33266152-1	2020	The new polymer inclusion membrane (PIM) with ethylenediamine-bis-acetylacetone (EDAB-acac) matrix was used for the separation of Zn(II) solutions containing non-ferrous metal ions (Co(II), Ni(II) Cu(II), Cd(II)).	Polymers	8-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	182-188
33260955-5	2020	Finally, the [P44414]Cl + CH3COOH system was applied to the treatment of real waste, NiMH battery black mass, being shown that it allows an efficient separation of Co(II) from Ni(II), Fe(III) and the lanthanides in a single leaching and separation step.	[p44414	13-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	164-170
33260955-5	2020	Finally, the [P44414]Cl + CH3COOH system was applied to the treatment of real waste, NiMH battery black mass, being shown that it allows an efficient separation of Co(II) from Ni(II), Fe(III) and the lanthanides in a single leaching and separation step.	Acetic Acid	26-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	164-170
33266152-1	2020	The new polymer inclusion membrane (PIM) with ethylenediamine-bis-acetylacetone (EDAB-acac) matrix was used for the separation of Zn(II) solutions containing non-ferrous metal ions (Co(II), Ni(II) Cu(II), Cd(II)).	zn(ii)	130-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	182-188
33266152-4	2020	The stability constants increase in series Ni(II) < Cu(II) < Co(II) < Cd(II) < Zn(II), and their logarithms are 8.85, 10.61, 12.73, 14.50, and 16.84, respectively.	Nickel(2+)	43-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-67
33266152-4	2020	The stability constants increase in series Ni(II) < Cu(II) < Co(II) < Cd(II) < Zn(II), and their logarithms are 8.85, 10.61, 12.73, 14.50, and 16.84, respectively.	cd(ii)	70-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-67
33266152-9	2020	They are, depending on the composition of the mixture, in the range 9.87-10.53 micromol/m2, 5.26-5.61 micromol/m2, and 7.43-7.84 micromol/m2 for Zn(II), Co(II), and Cd(II), respectively.	zn(ii)	145-151	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	153-159
33118558-1	2020	The Co(ii)-catalyzed selective C-H alkenylation of picolinamides with 1,3-diynes has been developed.	picolinamide	51-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
32186563-7	2020	A possible weak interaction between one of the chlorides and the carbenium moiety in the ligand is observed in crystals of both of the Co(ii) and Ni(ii) complexes with ligand L1.	Chlorides	47-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	138-140
33118558-1	2020	The Co(ii)-catalyzed selective C-H alkenylation of picolinamides with 1,3-diynes has been developed.	1,3-diynes	70-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
32186563-7	2020	A possible weak interaction between one of the chlorides and the carbenium moiety in the ligand is observed in crystals of both of the Co(ii) and Ni(ii) complexes with ligand L1.	carbenium	65-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-141
32186563-7	2020	A possible weak interaction between one of the chlorides and the carbenium moiety in the ligand is observed in crystals of both of the Co(ii) and Ni(ii) complexes with ligand L1.	carbenium	65-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	138-140
32239007-5	2020	In this manuscript, we report the ability of CoII and CoIII complexes of tri(2-pyridylmethyl)amine and N,N-di(2-pyridylmethyl)glycinate to disrupt zinc fingers.	tris(2-pyridylmethyl)amine	73-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-49
32239007-5	2020	In this manuscript, we report the ability of CoII and CoIII complexes of tri(2-pyridylmethyl)amine and N,N-di(2-pyridylmethyl)glycinate to disrupt zinc fingers.	n,n-di(2-pyridylmethyl)glycinate	103-135	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-49
33255269-7	2020	The MT-III-induced PGE2 biosynthesis was dependent on cytosolic PLA2 (cPLA2)-alpha, cyclooxygenases (COX)-1 and COX-2 pathways and regulated by a positive loop via the EP4 receptor.	Dinoprostone	19-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-117
33255789-2	2020	The Fenton reaction during the H2O2-catalyzed sol-gel synthesis utilized in this study lead to the partial formation of Co(III) in addition to Co(II) within the composites.	Hydrogen Peroxide	31-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	143-149
33391801-2	2020	Their binding behaviour was evaluated by complexing them with Co(II), Fe(II) and Zn(II) ions, which resulted in interesting coordination compounds with formulae, [Zn(tpy)2]PF6, [Co(tpy)2](PF6)2, [Fe(tpy)2](PF6)2 and interesting spectroscopic properties.	[zn(tpy)2]pf6	162-175	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-68
33391801-2	2020	Their binding behaviour was evaluated by complexing them with Co(II), Fe(II) and Zn(II) ions, which resulted in interesting coordination compounds with formulae, [Zn(tpy)2]PF6, [Co(tpy)2](PF6)2, [Fe(tpy)2](PF6)2 and interesting spectroscopic properties.	[co(tpy)2](pf6)2	177-193	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-68
33391801-2	2020	Their binding behaviour was evaluated by complexing them with Co(II), Fe(II) and Zn(II) ions, which resulted in interesting coordination compounds with formulae, [Zn(tpy)2]PF6, [Co(tpy)2](PF6)2, [Fe(tpy)2](PF6)2 and interesting spectroscopic properties.	[fe(tpy)2](pf6)2	195-211	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-68
33228233-6	2020	Moreover, the inhibition of beta-adrenoreceptors by propranolol enhanced apoptosis, decreased number of mitochondria and lowered the amount of proteins involved in oxidative phosphorylation (V-ATP5A, IV-COX2, III-UQCRC2, II-SDHB, I-NDUFB8).	Propranolol	52-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	203-207
33299414-0	2020	Bellidifolin Inhibits Proliferation of A549 Cells by Regulating STAT3/COX-2 Expression and Protein Activity.	bellidifolin	0-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-75
33299414-16	2020	Functional analyses further revealed that the cytotoxicity effect of BEL in A549 cells potentially involved the STAT3/COX-2 pathway.	bellidifolin	69-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-123
33140783-0	2020	Field-induced SIM behaviour of a Co(II) complex with a 1,1"-diacetylferrocene-derived ligand.	1,1"-diacetylferrocene	55-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-39
33089836-1	2020	CoII mediates electronic coupling between two N-Me-pyridinium-terpyridine ligands that are related to redox-active N,N-dialkyl-4,4"-bipyridinium dications (viologens).	n-me-pyridinium	46-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-4
33089836-1	2020	CoII mediates electronic coupling between two N-Me-pyridinium-terpyridine ligands that are related to redox-active N,N-dialkyl-4,4"-bipyridinium dications (viologens).	2,2':6',2''-Terpyridine	62-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-4
33089836-1	2020	CoII mediates electronic coupling between two N-Me-pyridinium-terpyridine ligands that are related to redox-active N,N-dialkyl-4,4"-bipyridinium dications (viologens).	n,n-dialkyl-4,4"-bipyridinium	115-144	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-4
33364964-7	2020	Earlier studies demonstrated that prostaglandin E2, produced through the action of COX-2, promoted cancer cell proliferation and metastasis in multiple cancers.	Dinoprostone	34-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
33140783-1	2020	Herein, we report the synthesis and magnetic properties of the Co(ii) coordination compound with the 1,1"-bis(1-((pyrid-2-ylmethylene)hydrazono)ethyl)ferrocene (L) ligand, having the general formula [CoLCl2].	1,1"-bis(1-((pyrid-2-ylmethylene)hydrazono)ethyl)ferrocene	101-159	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-69
33140783-1	2020	Herein, we report the synthesis and magnetic properties of the Co(ii) coordination compound with the 1,1"-bis(1-((pyrid-2-ylmethylene)hydrazono)ethyl)ferrocene (L) ligand, having the general formula [CoLCl2].	Leucine	161-163	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-69
33140783-1	2020	Herein, we report the synthesis and magnetic properties of the Co(ii) coordination compound with the 1,1"-bis(1-((pyrid-2-ylmethylene)hydrazono)ethyl)ferrocene (L) ligand, having the general formula [CoLCl2].	colcl2	200-206	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-69
33463025-2	2020	Among those SMMs based on one single transition metal, tetrahedral CoII-complexes are prominent, and their large zero-field splitting arises exclusively from coupling between the d  x  2 - y  2    and dxy orbitals.	Metals	48-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-71
32540704-0	2020	Preparation and characterization of ZnO/PEG-Co(II)-PbO2 nanocomposite electrode and an investigation of the electrocatalytic degradation of phenol.	pbo2	51-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-50
33100004-0	2020	Versatility of Amide-Functionalized Co(II) and Ni(II) Coordination Polymers: From Thermochromic-Triggered Structural Transformations to Supercapacitors and Electrocatalysts for Water Splitting.	Amides	15-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-42
33100004-0	2020	Versatility of Amide-Functionalized Co(II) and Ni(II) Coordination Polymers: From Thermochromic-Triggered Structural Transformations to Supercapacitors and Electrocatalysts for Water Splitting.	Water	177-182	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-42
32516652-7	2020	The hydroxide states of Co(III), Co(II), Cu(I) and Cu(II) were all able to activate PMS, indicating that there were many active sites on the surface of Co2Cu1 LDH.	hydroxide ion	4-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-39
33141572-11	2020	Multireference ab initio calculations, using the CASSCF/NEVPT2 approach, indicate that the strongly negative anisotropies of these Co(II) complexes arise primarily from distortions in the equatorial plane due to constrictions imposed by the TpPh2 ligand.	tpph2	241-246	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-137
32615221-0	2020	Adsorption of Cu (II)and Co (II) from aqueous solution using lignosulfonate/chitosan adsorbent.	lignosulfuric acid	61-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-32
32615221-0	2020	Adsorption of Cu (II)and Co (II) from aqueous solution using lignosulfonate/chitosan adsorbent.	Chitosan	76-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-32
32516652-7	2020	The hydroxide states of Co(III), Co(II), Cu(I) and Cu(II) were all able to activate PMS, indicating that there were many active sites on the surface of Co2Cu1 LDH.	co2cu1	152-158	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-39
32540704-1	2020	A ZnO/PEG (polyethylene glycol) -Co(II)-PbO2 nanocomposite electrode was constructed by using the anodic electrodeposition method and used for the electrocatalytic degradation phenol.	Zinc Oxide	2-5	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-39
32540704-1	2020	A ZnO/PEG (polyethylene glycol) -Co(II)-PbO2 nanocomposite electrode was constructed by using the anodic electrodeposition method and used for the electrocatalytic degradation phenol.	Polyethylene Glycols	6-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-39
32652152-0	2020	Biologically active Co (II), Cu (II), Zn (II) centered water soluble novel isoniazid grafted O-carboxymethyl chitosan Schiff base ligand metal complexes: Synthesis, spectral characterisation and DNA nuclease activity.	zn (ii)	38-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-27
32652152-0	2020	Biologically active Co (II), Cu (II), Zn (II) centered water soluble novel isoniazid grafted O-carboxymethyl chitosan Schiff base ligand metal complexes: Synthesis, spectral characterisation and DNA nuclease activity.	Water	55-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-27
32652152-0	2020	Biologically active Co (II), Cu (II), Zn (II) centered water soluble novel isoniazid grafted O-carboxymethyl chitosan Schiff base ligand metal complexes: Synthesis, spectral characterisation and DNA nuclease activity.	Isoniazid	75-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-27
32540704-1	2020	A ZnO/PEG (polyethylene glycol) -Co(II)-PbO2 nanocomposite electrode was constructed by using the anodic electrodeposition method and used for the electrocatalytic degradation phenol.	Polyethylene Glycols	11-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-39
32652152-0	2020	Biologically active Co (II), Cu (II), Zn (II) centered water soluble novel isoniazid grafted O-carboxymethyl chitosan Schiff base ligand metal complexes: Synthesis, spectral characterisation and DNA nuclease activity.	o-carboxymethyl chitosan schiff base	93-129	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-27
32652152-0	2020	Biologically active Co (II), Cu (II), Zn (II) centered water soluble novel isoniazid grafted O-carboxymethyl chitosan Schiff base ligand metal complexes: Synthesis, spectral characterisation and DNA nuclease activity.	Metals	137-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-27
32540704-1	2020	A ZnO/PEG (polyethylene glycol) -Co(II)-PbO2 nanocomposite electrode was constructed by using the anodic electrodeposition method and used for the electrocatalytic degradation phenol.	pbo2	40-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-39
32652152-1	2020	In this study, the new N, N, O tridentate donor water soluble isoniazid based biopolymer Schiff base ligand and their Co (II), Cu (II), Zn (II) metal complexes were prepared.	n, n, o	23-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-125
32652152-1	2020	In this study, the new N, N, O tridentate donor water soluble isoniazid based biopolymer Schiff base ligand and their Co (II), Cu (II), Zn (II) metal complexes were prepared.	Water	48-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-125
32652152-1	2020	In this study, the new N, N, O tridentate donor water soluble isoniazid based biopolymer Schiff base ligand and their Co (II), Cu (II), Zn (II) metal complexes were prepared.	Isoniazid	62-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-125
32652152-1	2020	In this study, the new N, N, O tridentate donor water soluble isoniazid based biopolymer Schiff base ligand and their Co (II), Cu (II), Zn (II) metal complexes were prepared.	Schiff Bases	89-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-125
32652152-1	2020	In this study, the new N, N, O tridentate donor water soluble isoniazid based biopolymer Schiff base ligand and their Co (II), Cu (II), Zn (II) metal complexes were prepared.	zn (ii)	136-143	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-125
32652152-1	2020	In this study, the new N, N, O tridentate donor water soluble isoniazid based biopolymer Schiff base ligand and their Co (II), Cu (II), Zn (II) metal complexes were prepared.	Metals	144-149	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-125
32652152-10	2020	The Cu (II) complexes showed better DNA binding results than Co (II) and Zn (II) complexes.	cu (ii)	4-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-80
32736050-11	2020	An offset on the warfarin induced soluble thrombomodulin induction was observed after its co-administration with DG, which could be partially attributed to the COX-2 inhibition effect of danshensu.	Warfarin	17-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	160-165
32540704-1	2020	A ZnO/PEG (polyethylene glycol) -Co(II)-PbO2 nanocomposite electrode was constructed by using the anodic electrodeposition method and used for the electrocatalytic degradation phenol.	Phenol	176-182	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-39
33148606-13	2020	Western blotting showed that celecoxib could partially reverse MIF-induced COX-2 upregulation and P53 downregulation.	Celecoxib	29-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
33044833-2	2020	This method features conversion of pyridotriazoles into two N-fused heterocyclic aromatic systems-imino-thiazolopyridines and oxo-thiazolopyridine derivatives-via one-step Co(II)-catalyzed transannulation reaction proceeding via a radical mechanism.	pyridotriazoles	35-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	172-178
33273889-4	2020	Our results demonstrated that PGE2 and its processing enzymes COX-2 and mPGES-1 were highest in the synovial tissue of RA, followed by the synovial tissue of OA and JT patients.	Dinoprostone	30-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
32729641-4	2020	While Co(II) possibly holds the record of having the largest number of zero-field SIMs known for any transition metal ions, controlling the magnetic anisotropy in these systems are is still a challenge.	Metals	112-117	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	6-12
33044833-2	2020	This method features conversion of pyridotriazoles into two N-fused heterocyclic aromatic systems-imino-thiazolopyridines and oxo-thiazolopyridine derivatives-via one-step Co(II)-catalyzed transannulation reaction proceeding via a radical mechanism.	imino-thiazolopyridines	98-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	172-178
33044833-2	2020	This method features conversion of pyridotriazoles into two N-fused heterocyclic aromatic systems-imino-thiazolopyridines and oxo-thiazolopyridine derivatives-via one-step Co(II)-catalyzed transannulation reaction proceeding via a radical mechanism.	oxo-thiazolopyridine	126-146	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	172-178
33167398-0	2020	Substitution of the Native Zn(II) with Cd(II), Co(II) and Ni(II) Changes the Downhill Unfolding Mechanism of Ros87 to a Completely Different Scenario.	ros87	109-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-53
33172183-3	2020	The paper presents a review of the literature related to the applications of polymer inclusion membranes containing alkylimidazole derivatives as carriers in the processes of transporting ions of heavy and toxic metals, such as Zn(II), Cu(II), Cd(II), Co(II), Ni(II), and Mn(II).	alkylimidazole	116-130	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	252-258
33167398-5	2020	Here, we explore the folding/unfolding behaviour of Ros87 coordinated to Co(II), Ni(II) or Cd(II), by UV-Vis, CD, DSC and NMR techniques.	ros87	52-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-79
33035279-1	2020	A robust and unusual three coordinate Co(ii) complex [Li(DME)3][Co(L)3] (1, where L = Lithium (2,6-diisopropylphenyl) amide and DME = Dimethoxyethane) shows easy plane magnetic anisotropy (D) which is validated by variable temperature X-band EPR studies.	li(dme)3]	54-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-44
32768854-4	2020	The PFRs enabled an efficient transfer electron to both cobalt atom and O2, facilitating the recycle of Co(III)/Co(II), and thereby leaded to an excellent catalytic performance.	Cobalt	56-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-118
32768854-4	2020	The PFRs enabled an efficient transfer electron to both cobalt atom and O2, facilitating the recycle of Co(III)/Co(II), and thereby leaded to an excellent catalytic performance.	Oxygen	72-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-118
33035279-1	2020	A robust and unusual three coordinate Co(ii) complex [Li(DME)3][Co(L)3] (1, where L = Lithium (2,6-diisopropylphenyl) amide and DME = Dimethoxyethane) shows easy plane magnetic anisotropy (D) which is validated by variable temperature X-band EPR studies.	tetracycline CMT-3	64-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-44
33035279-1	2020	A robust and unusual three coordinate Co(ii) complex [Li(DME)3][Co(L)3] (1, where L = Lithium (2,6-diisopropylphenyl) amide and DME = Dimethoxyethane) shows easy plane magnetic anisotropy (D) which is validated by variable temperature X-band EPR studies.	Lithium	86-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-44
33035279-1	2020	A robust and unusual three coordinate Co(ii) complex [Li(DME)3][Co(L)3] (1, where L = Lithium (2,6-diisopropylphenyl) amide and DME = Dimethoxyethane) shows easy plane magnetic anisotropy (D) which is validated by variable temperature X-band EPR studies.	2,6-diisopropylphenyl) amide	95-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-44
33035279-1	2020	A robust and unusual three coordinate Co(ii) complex [Li(DME)3][Co(L)3] (1, where L = Lithium (2,6-diisopropylphenyl) amide and DME = Dimethoxyethane) shows easy plane magnetic anisotropy (D) which is validated by variable temperature X-band EPR studies.	dimethylethylsilylimidazole	57-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-44
33035279-1	2020	A robust and unusual three coordinate Co(ii) complex [Li(DME)3][Co(L)3] (1, where L = Lithium (2,6-diisopropylphenyl) amide and DME = Dimethoxyethane) shows easy plane magnetic anisotropy (D) which is validated by variable temperature X-band EPR studies.	1,2-dimethoxyethane	134-149	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-44
33076661-3	2020	[CuII(H2O)8/3]3/2[FeII(CN)5(NH3)] showed higher catalytic activity than [CoII(H2O)8/3]3/2[FeII(CN)5(NH3)] and [GaIII(H2O)][FeII(CN)5(NH3)], although N-bound CuII species has been reported as less active than CoII and GaIII species in conventional PBAs.	Water	6-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-77
33076661-3	2020	[CuII(H2O)8/3]3/2[FeII(CN)5(NH3)] showed higher catalytic activity than [CoII(H2O)8/3]3/2[FeII(CN)5(NH3)] and [GaIII(H2O)][FeII(CN)5(NH3)], although N-bound CuII species has been reported as less active than CoII and GaIII species in conventional PBAs.	Water	6-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	208-212
33076661-3	2020	[CuII(H2O)8/3]3/2[FeII(CN)5(NH3)] showed higher catalytic activity than [CoII(H2O)8/3]3/2[FeII(CN)5(NH3)] and [GaIII(H2O)][FeII(CN)5(NH3)], although N-bound CuII species has been reported as less active than CoII and GaIII species in conventional PBAs.	Water	78-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-77
33076661-3	2020	[CuII(H2O)8/3]3/2[FeII(CN)5(NH3)] showed higher catalytic activity than [CoII(H2O)8/3]3/2[FeII(CN)5(NH3)] and [GaIII(H2O)][FeII(CN)5(NH3)], although N-bound CuII species has been reported as less active than CoII and GaIII species in conventional PBAs.	Water	78-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	208-212
33076661-3	2020	[CuII(H2O)8/3]3/2[FeII(CN)5(NH3)] showed higher catalytic activity than [CoII(H2O)8/3]3/2[FeII(CN)5(NH3)] and [GaIII(H2O)][FeII(CN)5(NH3)], although N-bound CuII species has been reported as less active than CoII and GaIII species in conventional PBAs.	Water	78-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-77
33076661-3	2020	[CuII(H2O)8/3]3/2[FeII(CN)5(NH3)] showed higher catalytic activity than [CoII(H2O)8/3]3/2[FeII(CN)5(NH3)] and [GaIII(H2O)][FeII(CN)5(NH3)], although N-bound CuII species has been reported as less active than CoII and GaIII species in conventional PBAs.	Water	78-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	208-212
33076661-3	2020	[CuII(H2O)8/3]3/2[FeII(CN)5(NH3)] showed higher catalytic activity than [CoII(H2O)8/3]3/2[FeII(CN)5(NH3)] and [GaIII(H2O)][FeII(CN)5(NH3)], although N-bound CuII species has been reported as less active than CoII and GaIII species in conventional PBAs.	Nitrogen	24-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-77
33076661-3	2020	[CuII(H2O)8/3]3/2[FeII(CN)5(NH3)] showed higher catalytic activity than [CoII(H2O)8/3]3/2[FeII(CN)5(NH3)] and [GaIII(H2O)][FeII(CN)5(NH3)], although N-bound CuII species has been reported as less active than CoII and GaIII species in conventional PBAs.	Nitrogen	24-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	208-212
33076661-4	2020	IR measurements of a series of the CN-deficient PBAs after the catalytic reactions clarified that a part of the NH3 ligands remained on [CoII(H2O)8/3]3/2[FeII(CN)5(NH3)] and that hydrogen phosphate formed as a product strongly adsorbed on the FeII ions of [GaIII(H2O)][FeII(CN)5(NH3)].	Water	142-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-141
33076661-4	2020	IR measurements of a series of the CN-deficient PBAs after the catalytic reactions clarified that a part of the NH3 ligands remained on [CoII(H2O)8/3]3/2[FeII(CN)5(NH3)] and that hydrogen phosphate formed as a product strongly adsorbed on the FeII ions of [GaIII(H2O)][FeII(CN)5(NH3)].	Hydrogen phosphate	179-197	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-141
33076661-4	2020	IR measurements of a series of the CN-deficient PBAs after the catalytic reactions clarified that a part of the NH3 ligands remained on [CoII(H2O)8/3]3/2[FeII(CN)5(NH3)] and that hydrogen phosphate formed as a product strongly adsorbed on the FeII ions of [GaIII(H2O)][FeII(CN)5(NH3)].	Water	263-266	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-141
32583175-6	2020	Further, the COX-2 and iNOS expression ratio was examined to recognize the connection of several trails to find the exact mode of action PEG-Mac@NPs and Iso.	Polyethylene Glycols	137-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
33011534-0	2020	Novel tetrazole-based selective COX-2 inhibitors: Design, synthesis, anti-inflammatory activity, evaluation of PGE2, TNF-alpha, IL-6 and histopathological study.	1H-tetrazole	6-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-37
33011534-1	2020	To search for effective and selective COX-2 inhibitors, four novel series of tetrazole derivatives were designed based on bioisosteric replacement of SO2NH2 in celecoxib with tetrazole ring incorporating different central moieties as chalcone (2a-f), isoxazole (3a-c) or pyrazole (4a-c & 5a-c).	1H-tetrazole	77-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-43
33011534-1	2020	To search for effective and selective COX-2 inhibitors, four novel series of tetrazole derivatives were designed based on bioisosteric replacement of SO2NH2 in celecoxib with tetrazole ring incorporating different central moieties as chalcone (2a-f), isoxazole (3a-c) or pyrazole (4a-c & 5a-c).	Celecoxib	160-169	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-43
33011534-3	2020	All target compounds were more selective for COX-2 isozyme than COX-1 when compared to standard drugs indomethacin and celecoxib.	Indomethacin	102-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-50
33011534-3	2020	All target compounds were more selective for COX-2 isozyme than COX-1 when compared to standard drugs indomethacin and celecoxib.	Celecoxib	119-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-50
33011534-5	2020	Trimethoxy derivatives 3c, 4c and 5c acquired superior COX-2 selectivity index values (SI = 297.67-317.95) and were 1.1 fold higher than celecoxib (SI = 282.22).	trimethoxy derivatives	0-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-60
33215449-11	2020	Parecoxib could also suppress CHOP caused by COX-2 upregulation and apoptosis in NP cells.	parecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-50
32583353-5	2020	RESULTS: The data elucidated that COX-2 and prostaglandins (PGs), particularly PGE2, have pro-inflammatory action in COVID-19 pathophysiology.	Dinoprostone	79-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-39
33215449-3	2020	This study investigated whether the specific COX-2 inhibitor parecoxib can inhibit NP cell apoptosis induced by ER stress.	parecoxib	61-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-50
32593823-5	2020	Integrating the trapping experiments and electrochemical analysis, we found the oxygen vacancy on B-TiO2-x capturing the electrons to promote the separation of photogenerated charges, meanwhile the Co(II) in the composite decomposed hydrogen peroxide (H2O2) to produce more  OH radical.	Oxygen	80-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	198-204
32593823-5	2020	Integrating the trapping experiments and electrochemical analysis, we found the oxygen vacancy on B-TiO2-x capturing the electrons to promote the separation of photogenerated charges, meanwhile the Co(II) in the composite decomposed hydrogen peroxide (H2O2) to produce more  OH radical.	Hydrogen Peroxide	233-250	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	198-204
32593823-5	2020	Integrating the trapping experiments and electrochemical analysis, we found the oxygen vacancy on B-TiO2-x capturing the electrons to promote the separation of photogenerated charges, meanwhile the Co(II) in the composite decomposed hydrogen peroxide (H2O2) to produce more  OH radical.	Hydrogen Peroxide	252-256	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	198-204
32593823-5	2020	Integrating the trapping experiments and electrochemical analysis, we found the oxygen vacancy on B-TiO2-x capturing the electrons to promote the separation of photogenerated charges, meanwhile the Co(II) in the composite decomposed hydrogen peroxide (H2O2) to produce more  OH radical.	oh radical	275-285	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	198-204
32763463-0	2020	Discovery of novel urea-diarylpyrazole hybrids as dual COX-2/sEH inhibitors with improved anti-inflammatory activity and highly reduced cardiovascular risks.	Urea	19-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-60
32160390-2	2020	Due to the low redox potential of the [CoII ]/CoI ]-couple, autoxidation of the corrinoid cofactor occurs and leads to the formation of the inactive [CoII ]-state.	Corrinoids	80-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-43
32160390-2	2020	Due to the low redox potential of the [CoII ]/CoI ]-couple, autoxidation of the corrinoid cofactor occurs and leads to the formation of the inactive [CoII ]-state.	Corrinoids	80-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	150-154
33215449-12	2020	CONCLUSIONS: Parecoxib is a safe and efficient COX-2 inhibitor to NP cells, which could prevent NP cells apoptosis by suppressing ER stress.	parecoxib	13-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
32892073-1	2020	LQFM219 is a molecule designed from celecoxibe (COX-2 inhibitor) and darbufelone (inhibitor of COX-2 and 5-LOX) lead compounds through a molecular hybridisation strategy.	lqfm219	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-53
32871348-3	2020	We evaluated the contribution of different side chains to binding of Co(II), Ni(II), Zn(II) and Mn(II) using systematic mutagenesis of the amino acids that constitute the primary metal coordination and outer spheres.	Metals	179-184	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-75
33016027-1	2020	SARS-Cov-2 infection causes local and systemic inflammation mediated by pro-inflammatory cytokines and COX-2 eicosanoid products with metabolic dysfunction and tissue damage that can lead to patient death.	Eicosanoids	109-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-108
33038834-3	2020	SARS-CoV (2003) induces Cox-2, catalyzing the synthesis, from highly unsaturated fatty acids (HUFA), of eicosanoids and docosanoids that mediate both inflammation and thrombosis.	docosanoids	120-131	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
32366935-3	2020	Here we show that mesenchymal stromal cells (MSCs) from patients with acute myeloid leukemia (AML) or normal MSCs overexpressing COX2 promote proliferation of co-cultured hematopoietic stem and progenitor cells (HSPCs), which can be prevented by treatment with COX2 knockdown or TM30089, a specific antagonist of the PGD2 receptor CRTH2.	CAY 10471	279-286	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-133
32934701-0	2020	Flurbiprofen suppresses the inflammation, proliferation, invasion and migration of colorectal cancer cells via COX2.	Flurbiprofen	0-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	111-115
32934701-5	2020	Subsequently, COX2 expression affected by flurbiprofen was tested using western blotting, reverse transcription-quantitative PCR and immunofluorescence.	Flurbiprofen	42-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-18
32934701-11	2020	Furthermore, it was identified that flurbiprofen inhibited the expression of COX2.	Flurbiprofen	36-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-81
32934701-12	2020	Notably, flurbiprofen suppressed the expression of inflammatory factors by inhibiting COX2.	Flurbiprofen	9-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-90
32934701-13	2020	Moreover, flurbiprofen inhibited the proliferation, invasion and migration of colorectal cancer cells by inhibiting COX2.	Flurbiprofen	10-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-120
32934701-14	2020	In conclusion, the present study revealed that flurbiprofen inhibited COX2 expression in colorectal cancer, and affected the proliferation, invasion, migration and apoptosis of colorectal cancer cells.	Flurbiprofen	47-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-74
32934701-15	2020	These results expand the understanding of the function of COX2 in colorectal cancer and the effect of flurbiprofen on COX2 expression.	Flurbiprofen	102-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-122
33038834-3	2020	SARS-CoV (2003) induces Cox-2, catalyzing the synthesis, from highly unsaturated fatty acids (HUFA), of eicosanoids and docosanoids that mediate both inflammation and thrombosis.	Fatty Acids, Unsaturated	69-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
33038834-3	2020	SARS-CoV (2003) induces Cox-2, catalyzing the synthesis, from highly unsaturated fatty acids (HUFA), of eicosanoids and docosanoids that mediate both inflammation and thrombosis.	hufa	94-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
33038834-3	2020	SARS-CoV (2003) induces Cox-2, catalyzing the synthesis, from highly unsaturated fatty acids (HUFA), of eicosanoids and docosanoids that mediate both inflammation and thrombosis.	Eicosanoids	104-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
33192533-9	2020	Chlorpromazine, a dopamine receptor blocker, not only weakened the analgesic effect of RTGT-MS, but also increased the levels of cAMP, PKA, COX-2, and PGE2.	Chlorpromazine	0-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-145
33100224-0	2020	miR-137 boosts the neuroprotective effect of endothelial progenitor cell-derived exosomes in oxyhemoglobin-treated SH-SY5Y cells partially via COX2/PGE2 pathway.	Dinoprostone	148-152	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	143-147
33138227-0	2020	Deposition of Tetracoordinate Co(II) Complex with Chalcone Ligands on Graphene.	Chalcone	50-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-36
33138227-0	2020	Deposition of Tetracoordinate Co(II) Complex with Chalcone Ligands on Graphene.	Graphite	70-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-36
33138227-2	2020	Herein, we probed the possibility to produce surface hybrids by depositing a Co(II)-based complex with chalcone ligands on chemical vapor deposition (CVD)-grown graphene by a wet-chemistry approach and by thermal sublimation under high vacuum.	Chalcone	103-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-83
33138227-2	2020	Herein, we probed the possibility to produce surface hybrids by depositing a Co(II)-based complex with chalcone ligands on chemical vapor deposition (CVD)-grown graphene by a wet-chemistry approach and by thermal sublimation under high vacuum.	Graphite	161-169	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-83
33100224-11	2020	Additionally, recombinational PGE2 was used to detect if activation of COX2/PGE2 pathway could reverse the protection of miR-137 overexpression.	Dinoprostone	76-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-75
33100224-14	2020	Furthermore, EXsmiR-137 rather than EXs can restore the decrease in miR-137 levels and inhibit ferroptosis, and the protection mechanism might involve the miR-137-COX2/PGE2 signaling pathway.	Dinoprostone	168-172	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	163-167
33209348-7	2020	The asymmetric unit of the complex is comprised of half the pyridine ring and water mol-ecule with the CoII atom at the center of the pincer situated about a twofold axis.	Water	78-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-107
32668065-6	2020	To overcome the long-range magnetic ordering, Co(II) ions are diluted in a diamagnetic Zn(II)-based matrix, which enables the single-molecule magnet (SMM) behaviour.	zn(ii)	87-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-52
33023288-6	2020	Photocatalytic H2 evolution is started by electron transfer (ET) from Cl4QH2 to the triplet ET state of Acr+-Mes to produce Cl4QH2 + and Acr -Mes with a rate constant of 7.2 x 107 M-1 s-1, followed by ET from Acr -Mes to CoIII(dmgH)2pyCl to produce [CoII(dmgH)2pyCl]-, accompanied by the regeneration of Acr+-Mes.	Deuterium	15-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	221-225
33023288-6	2020	Photocatalytic H2 evolution is started by electron transfer (ET) from Cl4QH2 to the triplet ET state of Acr+-Mes to produce Cl4QH2 + and Acr -Mes with a rate constant of 7.2 x 107 M-1 s-1, followed by ET from Acr -Mes to CoIII(dmgH)2pyCl to produce [CoII(dmgH)2pyCl]-, accompanied by the regeneration of Acr+-Mes.	cl4qh2	70-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	221-225
33023288-6	2020	Photocatalytic H2 evolution is started by electron transfer (ET) from Cl4QH2 to the triplet ET state of Acr+-Mes to produce Cl4QH2 + and Acr -Mes with a rate constant of 7.2 x 107 M-1 s-1, followed by ET from Acr -Mes to CoIII(dmgH)2pyCl to produce [CoII(dmgH)2pyCl]-, accompanied by the regeneration of Acr+-Mes.	cl4qh2 +	124-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	221-225
33023288-7	2020	On the other hand, Cl4QH2 + is deprotonated to produce Cl4QH , which transfers either a hydrogen-atom transfer or a proton-coupled electron transfer to [CoII(dmgH)2pyCl]- to produce a cobalt(III) hydride complex, [CoIII(H)(dmgH)2pyCl]-, which reacts with H+ to evolve H2, accompanied by the regeneration of CoIII(dmgH)2pyCl.	cl4qh2 +	19-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	153-157
33023288-7	2020	On the other hand, Cl4QH2 + is deprotonated to produce Cl4QH , which transfers either a hydrogen-atom transfer or a proton-coupled electron transfer to [CoII(dmgH)2pyCl]- to produce a cobalt(III) hydride complex, [CoIII(H)(dmgH)2pyCl]-, which reacts with H+ to evolve H2, accompanied by the regeneration of CoIII(dmgH)2pyCl.	cl4qh	19-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	153-157
33023288-7	2020	On the other hand, Cl4QH2 + is deprotonated to produce Cl4QH , which transfers either a hydrogen-atom transfer or a proton-coupled electron transfer to [CoII(dmgH)2pyCl]- to produce a cobalt(III) hydride complex, [CoIII(H)(dmgH)2pyCl]-, which reacts with H+ to evolve H2, accompanied by the regeneration of CoIII(dmgH)2pyCl.	Cobalt	184-203	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	153-157
33023288-7	2020	On the other hand, Cl4QH2 + is deprotonated to produce Cl4QH , which transfers either a hydrogen-atom transfer or a proton-coupled electron transfer to [CoII(dmgH)2pyCl]- to produce a cobalt(III) hydride complex, [CoIII(H)(dmgH)2pyCl]-, which reacts with H+ to evolve H2, accompanied by the regeneration of CoIII(dmgH)2pyCl.	Deuterium	23-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	153-157
33194674-9	2020	Unlike suprapharmacological dose, metronomic Celecoxib can only inhibit HCC cell invasion after a 7-day course of treatment via NF-kappaB/MMP9 dependent, COX2/PGE2 independent pathway.	Celecoxib	45-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	154-158
32926022-2	2020	One-electron oxidation of the paramagnetic low-spin CoII ion (SCo = 1/2) to the diamagnetic low-spin CoIII ion (SCo = 0) leads to the electroswitching of the slow magnetic relaxation in acetonitrile solution.	acetonitrile	186-198	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-56
33132637-13	2020	The PTEN inhibitor bpv (Hopic) reversed the high expression of PTEN and low expression of p-Akt and COX-2 that were induced by AKBA.	bromopyruvate	19-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-105
33066389-0	2020	Enhancing Effect of Chloride Ions on the Autocatalytic Process of Ag(I) Reduction by Co(II) Complexes.	Chlorides	20-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-91
33132637-14	2020	The Akt inhibitor MK2206 combined with AKBA down- regulated the expression of p-Akt and COX-2, and the combined effect was better than that of AKBA alone.	MK 2206	18-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-93
32935977-0	2020	Highly Selective and Active Electrochemical Reduction of CO2 to CO on a Polymeric Co(II) Phthalocyanine@Graphitic Carbon Nitride Nanosheet-Carbon Nanotube Composite.	Carbon Dioxide	57-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-88
32894945-10	2020	The 13C NMR characterization indicated further that Co(II) sites were mainly responsible for phenol adsorption.	Carbon-13	4-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-58
32894945-10	2020	The 13C NMR characterization indicated further that Co(II) sites were mainly responsible for phenol adsorption.	Phenol	93-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-58
32935977-0	2020	Highly Selective and Active Electrochemical Reduction of CO2 to CO on a Polymeric Co(II) Phthalocyanine@Graphitic Carbon Nitride Nanosheet-Carbon Nanotube Composite.	cyanogen	114-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-88
32935977-0	2020	Highly Selective and Active Electrochemical Reduction of CO2 to CO on a Polymeric Co(II) Phthalocyanine@Graphitic Carbon Nitride Nanosheet-Carbon Nanotube Composite.	Carbon	114-120	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-88
33083609-1	2020	A bidentate Schiff base ligand, MHMMT, obtained from 1,2,4-triazine derivative and 4-hydroxy-3-methoxy benzaldehyde and its Fe(III), Co(II), Ni(II), Cu(II), and Zn(II) complexes were synthesised in ethanolic media and characterized by various analytical techniques like elemental analyses, magnetic susceptibility measurements, FTIR, UV-VIS, proton NMR, ESR, spectroscopic and thermogravimetric studies.	Schiff Bases	12-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	133-139
33083609-1	2020	A bidentate Schiff base ligand, MHMMT, obtained from 1,2,4-triazine derivative and 4-hydroxy-3-methoxy benzaldehyde and its Fe(III), Co(II), Ni(II), Cu(II), and Zn(II) complexes were synthesised in ethanolic media and characterized by various analytical techniques like elemental analyses, magnetic susceptibility measurements, FTIR, UV-VIS, proton NMR, ESR, spectroscopic and thermogravimetric studies.	vanillin	83-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	133-139
32960573-0	2020	Formylation of Amines by CO2 Hydrogenation Using Preformed Co(II)/Nickel(II) Complexes.	Amines	15-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
32960573-0	2020	Formylation of Amines by CO2 Hydrogenation Using Preformed Co(II)/Nickel(II) Complexes.	Carbon Dioxide	25-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
32960573-0	2020	Formylation of Amines by CO2 Hydrogenation Using Preformed Co(II)/Nickel(II) Complexes.	Nickel(2+)	66-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
32935977-0	2020	Highly Selective and Active Electrochemical Reduction of CO2 to CO on a Polymeric Co(II) Phthalocyanine@Graphitic Carbon Nitride Nanosheet-Carbon Nanotube Composite.	Carbon Monoxide	57-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-88
32618021-0	2020	Anti-inflammatory and analgesic effect of LD-RT and some novel thiadiazole derivatives through COX-2 inhibition.	Thiadiazoles	63-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-100
32969214-4	2020	This study provides the first account of how CoII imine based supramolecules can be employed as H2O oxidation catalysts.	Water	96-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-49
32951426-2	2020	Under the excitation of ligand absorption bands, 1 exhibits the NIR luminescence of Yb(III) and displays high luminescence sensitivity and selectivity to Co(II), Cu(II), and 2,4,6-trinitrophenol (PA) at the parts per million level.	Protactinium	196-198	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	154-160
32485604-0	2020	Highly sensitive determination of Co(II) ions in solutions by using modified silver nanoparticles.	Silver	77-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-40
32485604-1	2020	In this manuscript, we report the development of a rapid and facile optic sensor for highly sensitive and selective detection of cobalt ions (Co(II)).	Cobalt	129-135	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	142-148
32485604-7	2020	Co(II) ions create a unique absorption peak during the complex formation and this peak provides sensitive determination of this metal ion in existence of other metal ions.	Metals	128-133	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
32485604-7	2020	Co(II) ions create a unique absorption peak during the complex formation and this peak provides sensitive determination of this metal ion in existence of other metal ions.	Metals	160-165	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
32485604-11	2020	The proposed metal ion sensor provides a very facile and convenient way to determine the concentration of Co(II) ions in aqueous system.	Metals	13-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-112
33072916-4	2020	Proliferation was measured in presence of COX-2 inhibitor Celecoxib (10-20 muM) revealing a decreased in vGPCR cell number, displaying typically apoptotic features in a dose dependent manner similarly to 1alpha,25(OH)2D3.	Celecoxib	58-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47
33072916-6	2020	Remarkably, although COX-2 mRNA and protein levels were up-regulated after 1alpha,25(OH)2D3 treatment, COX-2 enzymatic activity was reduced in a VDR-dependent manner.	Calcitriol	75-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-26
33072916-9	2020	Altogether, these results suggest a down-regulation of COX-2 activity and of prostanoid receptors as part of the antineoplastic mechanism of 1alpha,25(OH)2D3 in endothelial cells transformed by vGPCR.	Calcitriol	141-157	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-60
32618021-2	2020	Celecoxib is the highly marketed coxib, so there is still a need for the synthesis of COX-2 inhibitors with less adverse effects.	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-91
32710971-6	2020	Side-by-side comparison of 6BIGOE (0.1 microM) with the selective GSK-3 inhibitor SB216763 (5 microM) revealed congruent properties such as enrichment of beta-catenin and suppression of cyclooxygenase (COX)-2 protein levels due to GSK-3 inhibition.	6bigoe	27-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	186-208
32693180-10	2020	However, the presence of indole scaffold appeared to be responsible for COX-2 inhibitory effect.	indole	25-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
31961516-2	2020	An intravenous nanocrystal formulation of meloxicam, a COX-2 preferential nonsteroidal anti-inflammatory drug, is under development for the treatment of moderate to severe pain.	meloxicam	42-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-60
32350932-6	2020	Mechanistic investigations supported by Density Functional Theory (BP86) reveal that dihydrogen formation takes place in an intramolecular fashion through the participation of a methylene C-H bond of the HBMIM Ph2 ligand and a Co II -H bond through formal heterolytic splitting of the latter.	Hydrogen	85-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	227-232
32350932-6	2020	Mechanistic investigations supported by Density Functional Theory (BP86) reveal that dihydrogen formation takes place in an intramolecular fashion through the participation of a methylene C-H bond of the HBMIM Ph2 ligand and a Co II -H bond through formal heterolytic splitting of the latter.	Carbon	188-189	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	227-232
32451741-2	2020	A mathematical model (unsteady advection-dispersion-diffusion-adsorption equation) was solved analytically and numerically to simulate the dynamic adsorption of Co(II) ions on hydrogen peroxide-modified bone waste.	Hydrogen Peroxide	176-193	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	161-167
32945437-8	2020	The results revealed that Nitrodi spring water promoted cell migration and cell viability, and downregulated protein S-nitrosylation, probably also the nitrosylated active form of the cyclooxygenase (COX)-2 protein.	Water	41-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	184-206
32658799-4	2020	Because papilloma cells overexpress the epidermal growth factor receptor (EGFR), together with an increased expression of COX-2 and prostaglandin E2, the combination of erlotinib and celecoxib seems plausible, and could be proposed for patients with poor response to previous lines of treatment.	Celecoxib	183-192	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-127
32726604-7	2020	RESULTS: Pre-treatment with ISL (10 or 20 muM) dose-dependently decreased the mRNA levels of TNF-alpha, IL-6, ICAM-1, and COX-2 induced by ANG II (1 mug/ml) in both MPMs and HTFs.	isoliquiritigenin	28-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-127
32755990-8	2020	DHT pre-treatment inhibited LPS induced-mRNA expression of several pro-inflammatory mediators (i.e. COX2, IL6, IL12A and IFNgamma), effect significantly blunted by AR antagonist bicalutamide.	bicalutamide	178-190	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-104
32755990-8	2020	DHT pre-treatment inhibited LPS induced-mRNA expression of several pro-inflammatory mediators (i.e. COX2, IL6, IL12A and IFNgamma), effect significantly blunted by AR antagonist bicalutamide.	Dihydrotestosterone	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-104
32755990-11	2020	DHT pre-treatment significantly decreased IFNgamma-induced expression of HLA-DR, mRNA expression of iNOS, COX2 and MCP1, and secretion of IL1, IL2, IL5, IL6, MCP1 and GCSF.	Dihydrotestosterone	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-110
33025506-15	2020	Concentration dependent alleviation of chemoresistance development by curcumin was confirmed and was found to reduce gene level expression of P-glycoprotein and Cox-2.	Curcumin	70-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	161-166
32636028-0	2020	Corrigendum to "Macrophages induce EMT to promote invasion of lung cancer cells through the IL-6-mediated COX-2/PGE2/beta-catenin signalling pathway" [Mol.	Dinoprostone	112-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-111
33004893-4	2020	This paper proposes a computational analysis of eugenol in relation to aspirin and diclofenac and analyzing the ADMET profile and interactions with COX-2 and 5-LOX enzymes, important enzymes in the signaling pathway of pro-inflammatory processes.	admet	112-117	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	148-159
33004893-8	2020	The results of bioinformatics reinforce studies that try to propose eugenol as an anti-inflammatory compound that can act in the COX-2/5-LOX pathways, replacing some NSAIDs in different diseases.	Eugenol	68-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-134
32995789-3	2020	NSAIDs inhibit the enzymes cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2), which mediate the production of prostaglandins (PGs).	Prostaglandins	114-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
32894021-4	2020	Remarkably, photocatalytic CO2 reduction results indicate that COF-367-CoIII exhibits favorable activity and significantly enhanced selectivity to HCOOH, accordingly much reduced activ-ity and selectivity to CO and CH4, in sharp contrast to COF-367-CoII.	Carbon Dioxide	27-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-75
32894021-4	2020	Remarkably, photocatalytic CO2 reduction results indicate that COF-367-CoIII exhibits favorable activity and significantly enhanced selectivity to HCOOH, accordingly much reduced activ-ity and selectivity to CO and CH4, in sharp contrast to COF-367-CoII.	Metal-Organic Frameworks	63-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-75
32894021-4	2020	Remarkably, photocatalytic CO2 reduction results indicate that COF-367-CoIII exhibits favorable activity and significantly enhanced selectivity to HCOOH, accordingly much reduced activ-ity and selectivity to CO and CH4, in sharp contrast to COF-367-CoII.	formic acid	147-152	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-75
32894021-4	2020	Remarkably, photocatalytic CO2 reduction results indicate that COF-367-CoIII exhibits favorable activity and significantly enhanced selectivity to HCOOH, accordingly much reduced activ-ity and selectivity to CO and CH4, in sharp contrast to COF-367-CoII.	Carbon Monoxide	27-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-75
32894021-4	2020	Remarkably, photocatalytic CO2 reduction results indicate that COF-367-CoIII exhibits favorable activity and significantly enhanced selectivity to HCOOH, accordingly much reduced activ-ity and selectivity to CO and CH4, in sharp contrast to COF-367-CoII.	Methane	215-218	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-75
32894021-4	2020	Remarkably, photocatalytic CO2 reduction results indicate that COF-367-CoIII exhibits favorable activity and significantly enhanced selectivity to HCOOH, accordingly much reduced activ-ity and selectivity to CO and CH4, in sharp contrast to COF-367-CoII.	Metal-Organic Frameworks	241-244	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-75
32894021-6	2020	Theoretical calculations further disclose that the present of CoIII in COF-367-Co is preferable to the formation of HCOOH but detrimental to its further conversion, which clearly accounts for its distinctly different photocatalysis over COF-367-CoII.	formic acid	116-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-66
32995789-3	2020	NSAIDs inhibit the enzymes cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2), which mediate the production of prostaglandins (PGs).	Prostaglandins	130-133	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
32967696-0	2020	Correction to: Alantolactone, a natural sesquiterpene lactone, has potent antitumor activity against glioblastoma by targeting IKKbetakinase activity and interrupting NF-kappaB/COX-2-mediated signaling cascades.	alantolactone	15-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	177-182
32967672-9	2020	Similar effects were obtained by inhibiting COX2 by celecoxib, a clinically approved COX2 inhibitor.	Celecoxib	52-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-48
32967672-9	2020	Similar effects were obtained by inhibiting COX2 by celecoxib, a clinically approved COX2 inhibitor.	Celecoxib	52-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-89
32840994-6	2020	CM and CM/Bi4O5Br2/BiOBr showed higher affinity to Co(II) ions than to Ni(II) ions from diluted aqueous solutions.	bi4o5br2	10-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-57
32857504-3	2020	We have studied the speciation of Co(II), Zn(II), and Cu(II) in aqueous solutions containing different chloride salts to understand their extraction to the basic extractant methyltrioctylammonium chloride (TOMAC).	trioctylmethylammonium	173-204	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-40
32967203-9	2020	We found that piperine inhibited NF-kappaB by the activation of Nrf-2, blocking downstream inflammatory mediators/cytokines (TNF-alpha, IL-6, IL-1beta, Cox-2, PGE-2, iNOS, NO, MPO), triggering an antioxidant response machinery (HO-1, NQO-1, GSH, GR, GPx, CAT, SOD), scavenging ROS, and decreasing lipid peroxidation.	piperine	14-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-157
32857504-3	2020	We have studied the speciation of Co(II), Zn(II), and Cu(II) in aqueous solutions containing different chloride salts to understand their extraction to the basic extractant methyltrioctylammonium chloride (TOMAC).	trioctylmethylammonium	206-211	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-40
32553627-0	2020	Cox2-mediated PGE2 production via p38/JNK-c-fos signaling inhibits cell apoptosis in 3D floating culture clumps of mesenchymal stem cell/extracellular matrix complexes.	Dinoprostone	14-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-4
32553627-7	2020	Compared with cells cultured on 2D plastic plates, PGE2 production mediated by COX2 was significantly increased, and its inhibition drastically induced cell apoptosis in 3D floating-cultured C-MSCs.	Dinoprostone	51-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-83
32942970-1	2021	COX-2, a key enzyme that catalyzed the rate-limiting steps in the conversion of arachidonic acid to prostaglandins, played a pivotal role in inflammatory process.	Arachidonic Acid	80-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
32553627-9	2020	Moreover, blockage of this signaling by chemical inhibitors abrogated COX2/PGE2 expressions and induced severe apoptosis.	Dinoprostone	75-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-74
32942970-1	2021	COX-2, a key enzyme that catalyzed the rate-limiting steps in the conversion of arachidonic acid to prostaglandins, played a pivotal role in inflammatory process.	Prostaglandins	100-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
32942970-8	2021	According to the structural features, the natural COX-2 inhibitors were mainly divided into the following categories: natural phenols, flavonoids, stilbenes, terpenoids, quinones and alkaloids.	Phenols	126-133	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-55
32553627-10	2020	These results demonstrated that cell detachment facilitates cytoprotective COX2-mediated PGE2 synthesis via p38/JNK-c-Fos signaling, revealing a possible mechanism that allows resistance against anoikis in floating-cultured 3D MSCs constructs.	Dinoprostone	89-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-79
32942970-8	2021	According to the structural features, the natural COX-2 inhibitors were mainly divided into the following categories: natural phenols, flavonoids, stilbenes, terpenoids, quinones and alkaloids.	Flavonoids	135-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-55
32942970-8	2021	According to the structural features, the natural COX-2 inhibitors were mainly divided into the following categories: natural phenols, flavonoids, stilbenes, terpenoids, quinones and alkaloids.	Stilbenes	147-156	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-55
32942970-8	2021	According to the structural features, the natural COX-2 inhibitors were mainly divided into the following categories: natural phenols, flavonoids, stilbenes, terpenoids, quinones and alkaloids.	Terpenes	158-168	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-55
32942970-8	2021	According to the structural features, the natural COX-2 inhibitors were mainly divided into the following categories: natural phenols, flavonoids, stilbenes, terpenoids, quinones and alkaloids.	Quinones	170-178	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-55
33014864-0	2020	Combination of Tanshinone IIA and Cisplatin Inhibits Esophageal Cancer by Downregulating NF-kappaB/COX-2/VEGF Pathway.	tanshinone	15-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-104
32942970-8	2021	According to the structural features, the natural COX-2 inhibitors were mainly divided into the following categories: natural phenols, flavonoids, stilbenes, terpenoids, quinones and alkaloids.	Alkaloids	183-192	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-55
32938962-1	2020	It has been known for many years that the peroxidase activity of cyclooxygenase 1 and 2 (COX-1 and COX-2) can be reactivated in vitro by the presence of phenol, which serves as a reducing compound, but the underlying mechanism is still poorly understood.	Phenol	153-159	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-104
32840539-0	2020	Effecting structural diversity in a series of Co(II)-organic frameworks by the interplay between rigidity of a dicarboxylate and flexibility of bis(tridentate) spanning ligands.	malonic acid	111-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-52
32840539-0	2020	Effecting structural diversity in a series of Co(II)-organic frameworks by the interplay between rigidity of a dicarboxylate and flexibility of bis(tridentate) spanning ligands.	Bismuth	144-148	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-52
32840539-3	2020	The notable differences are (a) the binding mode of the tridentate part of polypyridyl ligands to the Co(ii) center is facial in 1a, 3a and 4a but meridional in 2a, (b) the Co(ii) centers in 1a-3a are hexacoordinated (with a coordinated water in 1a and 3a) but are pentacoordinated in 4a, and (c) the binding mode of tdc linker is bis(monodentate) in 1a, 3a and 4a but chelated in one end and monodentate in the other end in 2a.	Cobalt(2+)	173-179	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-108
32840539-3	2020	The notable differences are (a) the binding mode of the tridentate part of polypyridyl ligands to the Co(ii) center is facial in 1a, 3a and 4a but meridional in 2a, (b) the Co(ii) centers in 1a-3a are hexacoordinated (with a coordinated water in 1a and 3a) but are pentacoordinated in 4a, and (c) the binding mode of tdc linker is bis(monodentate) in 1a, 3a and 4a but chelated in one end and monodentate in the other end in 2a.	Water	237-242	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-108
32882139-1	2020	To help address efficient separation of C2Hn light hydrocarbons and C2H2/CO2 in the chemical industry, the self-assembly via an azolate-carboxylate ligand and Co(II) ion gave rise to a new porous MOF material, [Co(btzip)(H2btzip)] 2DMF 2H2O (1) (H2btzip = 4,6-bis(triazol-1-yl)isophthalic acid).	c2hn	40-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	159-165
32882139-1	2020	To help address efficient separation of C2Hn light hydrocarbons and C2H2/CO2 in the chemical industry, the self-assembly via an azolate-carboxylate ligand and Co(II) ion gave rise to a new porous MOF material, [Co(btzip)(H2btzip)] 2DMF 2H2O (1) (H2btzip = 4,6-bis(triazol-1-yl)isophthalic acid).	Hydrocarbons	51-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	159-165
32882139-1	2020	To help address efficient separation of C2Hn light hydrocarbons and C2H2/CO2 in the chemical industry, the self-assembly via an azolate-carboxylate ligand and Co(II) ion gave rise to a new porous MOF material, [Co(btzip)(H2btzip)] 2DMF 2H2O (1) (H2btzip = 4,6-bis(triazol-1-yl)isophthalic acid).	Acetylene	68-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	159-165
32882139-1	2020	To help address efficient separation of C2Hn light hydrocarbons and C2H2/CO2 in the chemical industry, the self-assembly via an azolate-carboxylate ligand and Co(II) ion gave rise to a new porous MOF material, [Co(btzip)(H2btzip)] 2DMF 2H2O (1) (H2btzip = 4,6-bis(triazol-1-yl)isophthalic acid).	Carbon Dioxide	73-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	159-165
32882139-1	2020	To help address efficient separation of C2Hn light hydrocarbons and C2H2/CO2 in the chemical industry, the self-assembly via an azolate-carboxylate ligand and Co(II) ion gave rise to a new porous MOF material, [Co(btzip)(H2btzip)] 2DMF 2H2O (1) (H2btzip = 4,6-bis(triazol-1-yl)isophthalic acid).	azolate-carboxylate	128-147	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	159-165
32882139-1	2020	To help address efficient separation of C2Hn light hydrocarbons and C2H2/CO2 in the chemical industry, the self-assembly via an azolate-carboxylate ligand and Co(II) ion gave rise to a new porous MOF material, [Co(btzip)(H2btzip)] 2DMF 2H2O (1) (H2btzip = 4,6-bis(triazol-1-yl)isophthalic acid).	[co(btzip)(h2btzip)] 2dmf 2h2o	210-240	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	159-165
32882139-1	2020	To help address efficient separation of C2Hn light hydrocarbons and C2H2/CO2 in the chemical industry, the self-assembly via an azolate-carboxylate ligand and Co(II) ion gave rise to a new porous MOF material, [Co(btzip)(H2btzip)] 2DMF 2H2O (1) (H2btzip = 4,6-bis(triazol-1-yl)isophthalic acid).	4,6-bis(triazol-1-yl)isophthalic acid	256-293	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	159-165
32927723-5	2020	In-vitro tests were performed to assess their effects on cyclo-oxygenase enzyme (COX)-1 and COX-2, namely inhibition of platelet aggregation and thromboxane B2 production in the human-platelet-rich plasma, and reduction of Prostaglandin-E2 production in lipopolysaccharide-treated-RAW-264.7 macrophage cell line.	Thromboxane B2	145-159	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-97
32984710-1	2020	A new type of absorbent with high efficiency was synthesized by KOH-activated slag-based geopolymer microspheres (K-SGM), which exhibited higher adsorption capacities for recycling Co(II) (Q e,K-SGM = 192.31 mg/g, Q e,Na-SGM = 91.21 mg/g) than NaOH-activated ones (Na-SGM).	potassium hydroxide	64-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	181-187
32984710-2	2020	During the Co(II) adsorption process, these two kinds of geopolymeric adsorbents could be combined with heavy metal ions to optimize each other and form heavy metal-grown aid adsorbents.	Metals	110-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-17
32984710-2	2020	During the Co(II) adsorption process, these two kinds of geopolymeric adsorbents could be combined with heavy metal ions to optimize each other and form heavy metal-grown aid adsorbents.	Metals	159-164	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-17
33014864-0	2020	Combination of Tanshinone IIA and Cisplatin Inhibits Esophageal Cancer by Downregulating NF-kappaB/COX-2/VEGF Pathway.	Cisplatin	34-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-104
32815718-1	2020	The influence of a redox-active ligand on spin-changing events induced by the coordination of exogenous donors is investigated within the cobalt complex [CoII(DPP 2-)], bearing a redox-active DPP2- ligand (DPP = dipyrrin-bis(o,p-di-tert-butylphenolato) with a pentafluorophenyl moiety on the meso-position.	Cobalt	138-144	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	154-158
32815718-1	2020	The influence of a redox-active ligand on spin-changing events induced by the coordination of exogenous donors is investigated within the cobalt complex [CoII(DPP 2-)], bearing a redox-active DPP2- ligand (DPP = dipyrrin-bis(o,p-di-tert-butylphenolato) with a pentafluorophenyl moiety on the meso-position.	dipalmitoylphosphatidylserine	159-162	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	154-158
32815718-4	2020	The redox-active DPPn- ligand plays a crucial role in stabilizing this complex and in its facile conversion to the triplet THF adduct [CoII(DPP 2-)(THF)2] and closed-shell singlet pyridine and amine adducts [CoIII(DPP3-)(L)2] (L = py, tBuNH2, or AdNH2).	dppn	17-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-139
32815718-4	2020	The redox-active DPPn- ligand plays a crucial role in stabilizing this complex and in its facile conversion to the triplet THF adduct [CoII(DPP 2-)(THF)2] and closed-shell singlet pyridine and amine adducts [CoIII(DPP3-)(L)2] (L = py, tBuNH2, or AdNH2).	tetrahydrofuran	123-126	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-139
32815718-4	2020	The redox-active DPPn- ligand plays a crucial role in stabilizing this complex and in its facile conversion to the triplet THF adduct [CoII(DPP 2-)(THF)2] and closed-shell singlet pyridine and amine adducts [CoIII(DPP3-)(L)2] (L = py, tBuNH2, or AdNH2).	singlet pyridine	172-188	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-139
32815718-4	2020	The redox-active DPPn- ligand plays a crucial role in stabilizing this complex and in its facile conversion to the triplet THF adduct [CoII(DPP 2-)(THF)2] and closed-shell singlet pyridine and amine adducts [CoIII(DPP3-)(L)2] (L = py, tBuNH2, or AdNH2).	Amines	193-198	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-139
32568423-3	2020	Atomic replacements of the Fe II by other metal(II) ions (e.g., Zn II /Co II ) via synthesizing isostructural trinuclear-complex precursors (Fe 2 Zn/Fe 2 Co), namely the "heteroatom modulator approach", realizes the inhibition of iron atoms aggregating toward nanoclusters with formation of a stable iron-dimer cluster in an optimal metal-nitrogen moiety within the carbon layer, clearly identified by direct transmission electron microscope imaging with X-ray absorption fine structure analyses.	Iron	141-143	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-76
32568423-3	2020	Atomic replacements of the Fe II by other metal(II) ions (e.g., Zn II /Co II ) via synthesizing isostructural trinuclear-complex precursors (Fe 2 Zn/Fe 2 Co), namely the "heteroatom modulator approach", realizes the inhibition of iron atoms aggregating toward nanoclusters with formation of a stable iron-dimer cluster in an optimal metal-nitrogen moiety within the carbon layer, clearly identified by direct transmission electron microscope imaging with X-ray absorption fine structure analyses.	Iron	230-234	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-76
32815718-4	2020	The redox-active DPPn- ligand plays a crucial role in stabilizing this complex and in its facile conversion to the triplet THF adduct [CoII(DPP 2-)(THF)2] and closed-shell singlet pyridine and amine adducts [CoIII(DPP3-)(L)2] (L = py, tBuNH2, or AdNH2).	tert-butylamine	235-241	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-139
32568423-3	2020	Atomic replacements of the Fe II by other metal(II) ions (e.g., Zn II /Co II ) via synthesizing isostructural trinuclear-complex precursors (Fe 2 Zn/Fe 2 Co), namely the "heteroatom modulator approach", realizes the inhibition of iron atoms aggregating toward nanoclusters with formation of a stable iron-dimer cluster in an optimal metal-nitrogen moiety within the carbon layer, clearly identified by direct transmission electron microscope imaging with X-ray absorption fine structure analyses.	Iron	300-304	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-76
32568423-3	2020	Atomic replacements of the Fe II by other metal(II) ions (e.g., Zn II /Co II ) via synthesizing isostructural trinuclear-complex precursors (Fe 2 Zn/Fe 2 Co), namely the "heteroatom modulator approach", realizes the inhibition of iron atoms aggregating toward nanoclusters with formation of a stable iron-dimer cluster in an optimal metal-nitrogen moiety within the carbon layer, clearly identified by direct transmission electron microscope imaging with X-ray absorption fine structure analyses.	Metals	333-338	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-76
32568423-3	2020	Atomic replacements of the Fe II by other metal(II) ions (e.g., Zn II /Co II ) via synthesizing isostructural trinuclear-complex precursors (Fe 2 Zn/Fe 2 Co), namely the "heteroatom modulator approach", realizes the inhibition of iron atoms aggregating toward nanoclusters with formation of a stable iron-dimer cluster in an optimal metal-nitrogen moiety within the carbon layer, clearly identified by direct transmission electron microscope imaging with X-ray absorption fine structure analyses.	Nitrogen	339-347	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-76
32568423-3	2020	Atomic replacements of the Fe II by other metal(II) ions (e.g., Zn II /Co II ) via synthesizing isostructural trinuclear-complex precursors (Fe 2 Zn/Fe 2 Co), namely the "heteroatom modulator approach", realizes the inhibition of iron atoms aggregating toward nanoclusters with formation of a stable iron-dimer cluster in an optimal metal-nitrogen moiety within the carbon layer, clearly identified by direct transmission electron microscope imaging with X-ray absorption fine structure analyses.	Carbon	366-372	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-76
32815718-4	2020	The redox-active DPPn- ligand plays a crucial role in stabilizing this complex and in its facile conversion to the triplet THF adduct [CoII(DPP 2-)(THF)2] and closed-shell singlet pyridine and amine adducts [CoIII(DPP3-)(L)2] (L = py, tBuNH2, or AdNH2).	adnh2	246-251	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-139
32815718-5	2020	Coordination of the weak donor THF to [CoII(DPP 2-)] changes the orbital overlap between the DPP 2- ligand radical pi-orbitals and the cobalt(II) metalloradical d-orbitals, which results in a spin-flip to the triplet ground state without changing the oxidation states of the metal or DPP 2- ligand.	tetrahydrofuran	31-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-43
32944715-3	2020	Twelve novel compounds (aryl acetate and aryl acetic acid groups) were synthesized in this work in order to identify which one was the most potent and which group was most selective towards COX1 and COX2 by using an in vitro COX inhibition assay kit.	aryl acetate	24-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	199-203
32815718-5	2020	Coordination of the weak donor THF to [CoII(DPP 2-)] changes the orbital overlap between the DPP 2- ligand radical pi-orbitals and the cobalt(II) metalloradical d-orbitals, which results in a spin-flip to the triplet ground state without changing the oxidation states of the metal or DPP 2- ligand.	Cobalt(2+)	135-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-43
32944715-3	2020	Twelve novel compounds (aryl acetate and aryl acetic acid groups) were synthesized in this work in order to identify which one was the most potent and which group was most selective towards COX1 and COX2 by using an in vitro COX inhibition assay kit.	aryl acetic acid	41-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	199-203
32815718-5	2020	Coordination of the weak donor THF to [CoII(DPP 2-)] changes the orbital overlap between the DPP 2- ligand radical pi-orbitals and the cobalt(II) metalloradical d-orbitals, which results in a spin-flip to the triplet ground state without changing the oxidation states of the metal or DPP 2- ligand.	Metals	146-151	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-43
32528119-0	2020	Ibuprofen mediates histone modification to diminish cancer cell stemness properties via a COX2-dependent manner.	Ibuprofen	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-94
32899726-9	2020	Curcumin and CGA together reduced the mRNA expression of pro-inflammatory cytokines [TNF-alpha (~88%) and IL-6 (~99%)], and COX-2 (~92%), possibly by suppression of NF-kappaB (~78%), IkappaB-beta-kinase (~60%) and TLR-4 receptor (~72%) at the mRNA level.	Curcumin	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	124-129
32879137-4	2020	Using single-cell RNA sequencing of human wound tissue, we identify increased NF-kappaB-mediated inflammation in diabetic wounds and show increased COX-2/PGE2 in diabetic macrophages.	Dinoprostone	154-158	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	148-153
32879137-5	2020	Further, we identify that COX-2/PGE2 production in wound macrophages requires epigenetic regulation of 2 key enzymes in the cytosolic phospholipase A2/COX-2/PGE2 (cPLA2/COX-2/PGE2) pathway.	Dinoprostone	32-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-31
32879137-5	2020	Further, we identify that COX-2/PGE2 production in wound macrophages requires epigenetic regulation of 2 key enzymes in the cytosolic phospholipase A2/COX-2/PGE2 (cPLA2/COX-2/PGE2) pathway.	Dinoprostone	32-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-156
32879137-5	2020	Further, we identify that COX-2/PGE2 production in wound macrophages requires epigenetic regulation of 2 key enzymes in the cytosolic phospholipase A2/COX-2/PGE2 (cPLA2/COX-2/PGE2) pathway.	Dinoprostone	32-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-156
32879137-5	2020	Further, we identify that COX-2/PGE2 production in wound macrophages requires epigenetic regulation of 2 key enzymes in the cytosolic phospholipase A2/COX-2/PGE2 (cPLA2/COX-2/PGE2) pathway.	Dinoprostone	157-161	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-31
32879137-5	2020	Further, we identify that COX-2/PGE2 production in wound macrophages requires epigenetic regulation of 2 key enzymes in the cytosolic phospholipase A2/COX-2/PGE2 (cPLA2/COX-2/PGE2) pathway.	Dinoprostone	157-161	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-156
32879137-5	2020	Further, we identify that COX-2/PGE2 production in wound macrophages requires epigenetic regulation of 2 key enzymes in the cytosolic phospholipase A2/COX-2/PGE2 (cPLA2/COX-2/PGE2) pathway.	Dinoprostone	157-161	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-156
32879137-5	2020	Further, we identify that COX-2/PGE2 production in wound macrophages requires epigenetic regulation of 2 key enzymes in the cytosolic phospholipase A2/COX-2/PGE2 (cPLA2/COX-2/PGE2) pathway.	Dinoprostone	157-161	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-31
32879137-5	2020	Further, we identify that COX-2/PGE2 production in wound macrophages requires epigenetic regulation of 2 key enzymes in the cytosolic phospholipase A2/COX-2/PGE2 (cPLA2/COX-2/PGE2) pathway.	Dinoprostone	157-161	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-156
32879137-5	2020	Further, we identify that COX-2/PGE2 production in wound macrophages requires epigenetic regulation of 2 key enzymes in the cytosolic phospholipase A2/COX-2/PGE2 (cPLA2/COX-2/PGE2) pathway.	Dinoprostone	157-161	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-156
32879137-6	2020	We demonstrate that TGF-beta-induced miRNA29b increases COX-2/PGE2 production via inhibition of DNA methyltransferase 3b-mediated hypermethylation of the Cox-2 promoter.	Dinoprostone	62-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-61
32879137-6	2020	We demonstrate that TGF-beta-induced miRNA29b increases COX-2/PGE2 production via inhibition of DNA methyltransferase 3b-mediated hypermethylation of the Cox-2 promoter.	Dinoprostone	62-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	154-159
32879137-7	2020	Further, we find mixed-lineage leukemia 1 (MLL1) upregulates cPLA2 expression and drives COX-2/PGE2.	Dinoprostone	95-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-94
32879137-8	2020	Inhibition of the COX-2/PGE2 pathway genetically (Cox2fl/fl Lyz2Cre+) or with a macrophage-specific nanotherapy targeting COX-2 in tissue macrophages reverses the inflammatory macrophage phenotype and improves diabetic tissue repair.	Dinoprostone	24-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-23
32879137-8	2020	Inhibition of the COX-2/PGE2 pathway genetically (Cox2fl/fl Lyz2Cre+) or with a macrophage-specific nanotherapy targeting COX-2 in tissue macrophages reverses the inflammatory macrophage phenotype and improves diabetic tissue repair.	lyz2cre	60-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-23
32801081-0	2020	Synthesis, in vivo anti-inflammatory, COX-1/COX-2 and 5-LOX inhibitory activities of new 2,3,4-trisubstituted thiophene derivatives.	2,3,4-trisubstituted	89-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-55
32801081-0	2020	Synthesis, in vivo anti-inflammatory, COX-1/COX-2 and 5-LOX inhibitory activities of new 2,3,4-trisubstituted thiophene derivatives.	Thiophenes	110-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-55
32801081-3	2020	The in vitro assay results revealed that the N-(4-(4-chlorophenyl)-3-cyanothiophen-2-yl)-2-morpholinoacetamide (5b) possesses the highest selectivity toward COX-2 (IC50 = 5.45 muM) with selectivity index value of 8.37 compared to celecoxib with COX-2 selectivity index value of 15.44.	n-(4-(4-chlorophenyl)-3-cyanothiophen-2-yl)-2-morpholinoacetamide	45-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	157-162
32801081-3	2020	The in vitro assay results revealed that the N-(4-(4-chlorophenyl)-3-cyanothiophen-2-yl)-2-morpholinoacetamide (5b) possesses the highest selectivity toward COX-2 (IC50 = 5.45 muM) with selectivity index value of 8.37 compared to celecoxib with COX-2 selectivity index value of 15.44.	n-(4-(4-chlorophenyl)-3-cyanothiophen-2-yl)-2-morpholinoacetamide	45-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	245-250
32801081-3	2020	The in vitro assay results revealed that the N-(4-(4-chlorophenyl)-3-cyanothiophen-2-yl)-2-morpholinoacetamide (5b) possesses the highest selectivity toward COX-2 (IC50 = 5.45 muM) with selectivity index value of 8.37 compared to celecoxib with COX-2 selectivity index value of 15.44.	Celecoxib	230-239	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	157-162
32801081-3	2020	The in vitro assay results revealed that the N-(4-(4-chlorophenyl)-3-cyanothiophen-2-yl)-2-morpholinoacetamide (5b) possesses the highest selectivity toward COX-2 (IC50 = 5.45 muM) with selectivity index value of 8.37 compared to celecoxib with COX-2 selectivity index value of 15.44.	Celecoxib	230-239	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	245-250
32899627-2	2020	Almost all of the COX2 imaging agents using celecoxib as backbone were chemically modified in the position of N-atom in the sulfonamide group.	Celecoxib	44-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-22
32899627-2	2020	Almost all of the COX2 imaging agents using celecoxib as backbone were chemically modified in the position of N-atom in the sulfonamide group.	Nitrogen	110-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-22
32899627-2	2020	Almost all of the COX2 imaging agents using celecoxib as backbone were chemically modified in the position of N-atom in the sulfonamide group.	Sulfonamides	124-135	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-22
32707279-0	2020	Discovery of novel aminophosphonate derivatives containing pyrazole moiety as potential selective COX-2 inhibitors.	phosphoramidic acid	19-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-103
32707279-0	2020	Discovery of novel aminophosphonate derivatives containing pyrazole moiety as potential selective COX-2 inhibitors.	pyrazole	59-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-103
32721780-6	2020	Moreover, every examined derivative of pyrrolo[3,4-d]pyridazinone demonstrates better inhibitory activity towards COX-2 and a superior COX-2/COX-1 selectivity ratio compared to the reference drug meloxicam.	pyrrolo(3,4-d)pyridazinone	39-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-119
32721780-6	2020	Moreover, every examined derivative of pyrrolo[3,4-d]pyridazinone demonstrates better inhibitory activity towards COX-2 and a superior COX-2/COX-1 selectivity ratio compared to the reference drug meloxicam.	pyrrolo(3,4-d)pyridazinone	39-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-140
32721780-6	2020	Moreover, every examined derivative of pyrrolo[3,4-d]pyridazinone demonstrates better inhibitory activity towards COX-2 and a superior COX-2/COX-1 selectivity ratio compared to the reference drug meloxicam.	Meloxicam	196-205	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-119
32721780-6	2020	Moreover, every examined derivative of pyrrolo[3,4-d]pyridazinone demonstrates better inhibitory activity towards COX-2 and a superior COX-2/COX-1 selectivity ratio compared to the reference drug meloxicam.	Meloxicam	196-205	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-140
32738961-0	2020	Synthesis and evaluations of selective COX-2 inhibitory effects: Benzo[d]thiazol analogs.	benzo[d]thiazol	65-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-44
32738961-7	2020	This benzo[d]thiazole moiety will be proved to be of great significance for developing more potent COX-2 inhibitors.	benzothiazole	5-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-104
32528119-9	2020	In regard to the underlying molecular mechanism of action, we report that ibuprofen reduces HDACs and histone demethylase (KDM6A/B) expression that mediates histone acetylation and methylation, and suppresses gene expression via a COX2-dependent way.	Ibuprofen	74-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	231-235
32533792-3	2020	METHODS: In a randomized, double-blind, placebo-controlled biomarker trial involving 34 patients, the beta-blocker propranolol and the COX2-inhibitor etodolac were administered for 20 perioperative days, starting 5 days before surgery.	Etodolac	150-158	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-139
32640357-3	2020	Cirsilineol exhibited good binding-energy and inhibited the activity of ODC, CATD, DHFR, HYAL, LOX-5, and COX-2 up to 45.14 % at 100muM.	cirsilineol	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-111
32772580-1	2020	In the present study, we searched selective cytotoxicity and mitochondria mediated apoptosis of novel COX-2 inhibitor 2-(4-(Methylsulfonyl)phenyl)imidazo[1,2-a] pyridine-8-carboxylic acid on B-lymphocytes and their mitochondria isolated from normal subjects and ALL patients" blood.	2-(4-(methylsulfonyl)phenyl)imidazo[1,2-a] pyridine-8-carboxylic acid	118-187	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-107
32957283-0	2020	Co(II) and Ni(II) transport from model and real sulfate solutions by extraction with bis(2,4,4-trimethylpentyl)phosphinic acid (Cyanex 272).	Sulfates	48-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
32957283-0	2020	Co(II) and Ni(II) transport from model and real sulfate solutions by extraction with bis(2,4,4-trimethylpentyl)phosphinic acid (Cyanex 272).	Cyanex 272	85-126	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
32957283-0	2020	Co(II) and Ni(II) transport from model and real sulfate solutions by extraction with bis(2,4,4-trimethylpentyl)phosphinic acid (Cyanex 272).	Cyanex 272	128-138	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
32957283-1	2020	This paper presents the results of Co(II) and Ni(II) extraction from model and real solutions using bis(2,4,4-trimethylpentyl)phosphinic acid (i.e. Cyanex 272) that are in agreement with waste-to-resources approach, i.e. the recovery of valuable components from wastes.	Cyanex 272	100-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-41
32957283-1	2020	This paper presents the results of Co(II) and Ni(II) extraction from model and real solutions using bis(2,4,4-trimethylpentyl)phosphinic acid (i.e. Cyanex 272) that are in agreement with waste-to-resources approach, i.e. the recovery of valuable components from wastes.	Cyanex 272	148-158	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-41
32957283-2	2020	The results from this study shows that, extraction using Cyanex 272 is an efficient method to recover Co(II) selectively from sulfate electrolytes obtained from the leaching of steel scraps of aircraft engines.	Cyanex 272	57-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-108
32957283-2	2020	The results from this study shows that, extraction using Cyanex 272 is an efficient method to recover Co(II) selectively from sulfate electrolytes obtained from the leaching of steel scraps of aircraft engines.	Sulfates	126-133	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-108
32957283-3	2020	The highest selectivity value (~160) of Co(II) extraction over Ni(II) was obtained at a pH of 4.8, the lowest selectivity value (~30) was observed at a pH of 5.5, while above this value the selectivity only increased slightly with increasing pH.	Nickel(2+)	63-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-46
32957283-5	2020	The essence of the investigation is to propose important parameters to extract Co(II) from real leach solutions, and to further recover valuable Co(II) from the loaded organic phase by stripping with 1 M H2SO4, thus producing an electrolyte of Co(II) for electrowinning - a possible alternative route for resource recovery.	sulfuric acid	204-209	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-151
32957283-6	2020	Small volume of the stripping phase (w/o = 1:5) used in this study, lead to an enrichment of sulfate electrolyte in Co(II), resulting in ~50 g/dm3 of Co(II) in the solution, which is a great advantage of the approach proposed.	Sulfates	93-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-122
32957283-6	2020	Small volume of the stripping phase (w/o = 1:5) used in this study, lead to an enrichment of sulfate electrolyte in Co(II), resulting in ~50 g/dm3 of Co(II) in the solution, which is a great advantage of the approach proposed.	Sulfates	93-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	150-156
32957283-6	2020	Small volume of the stripping phase (w/o = 1:5) used in this study, lead to an enrichment of sulfate electrolyte in Co(II), resulting in ~50 g/dm3 of Co(II) in the solution, which is a great advantage of the approach proposed.	DM3	143-146	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-122
32957283-6	2020	Small volume of the stripping phase (w/o = 1:5) used in this study, lead to an enrichment of sulfate electrolyte in Co(II), resulting in ~50 g/dm3 of Co(II) in the solution, which is a great advantage of the approach proposed.	DM3	143-146	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	150-156
32540488-7	2020	Additionally, the mRNA and protein level of COX2 and ACSL4 were obviously upregulated, but the GPX4 and FTH1 expression were downregulated in 3% DSS group (P < 0.05); however, the expression level of COX2, ACSL4, GPX4 and FTH1 was revered after ferrostatin-1, liproxstatin-1 (Lip-1) or deferprone (DFP) administration.	Isoflurophate	298-301	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	200-204
32516287-1	2020	OBJECTIVE: Cyclooxygenase (COX)-2, an inducible isoform of the major rate-limiting enzymes that regulate the production of prostaglandins is associated with injury, inflammation and proliferation.	Prostaglandins	123-137	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-33
32540488-5	2020	The results suggested that the expression of COX2 and ACSL4 was increased dramatically, while the level of GPX4 and FTH1 was deceased in 3% DSS group compared with Control group (P < 0.05).	Dextran Sulfate	140-143	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-49
32540488-7	2020	Additionally, the mRNA and protein level of COX2 and ACSL4 were obviously upregulated, but the GPX4 and FTH1 expression were downregulated in 3% DSS group (P < 0.05); however, the expression level of COX2, ACSL4, GPX4 and FTH1 was revered after ferrostatin-1, liproxstatin-1 (Lip-1) or deferprone (DFP) administration.	Dextran Sulfate	145-148	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-48
32540488-7	2020	Additionally, the mRNA and protein level of COX2 and ACSL4 were obviously upregulated, but the GPX4 and FTH1 expression were downregulated in 3% DSS group (P < 0.05); however, the expression level of COX2, ACSL4, GPX4 and FTH1 was revered after ferrostatin-1, liproxstatin-1 (Lip-1) or deferprone (DFP) administration.	Dextran Sulfate	145-148	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	200-204
32540488-7	2020	Additionally, the mRNA and protein level of COX2 and ACSL4 were obviously upregulated, but the GPX4 and FTH1 expression were downregulated in 3% DSS group (P < 0.05); however, the expression level of COX2, ACSL4, GPX4 and FTH1 was revered after ferrostatin-1, liproxstatin-1 (Lip-1) or deferprone (DFP) administration.	ferrostatin	245-256	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	200-204
32540488-7	2020	Additionally, the mRNA and protein level of COX2 and ACSL4 were obviously upregulated, but the GPX4 and FTH1 expression were downregulated in 3% DSS group (P < 0.05); however, the expression level of COX2, ACSL4, GPX4 and FTH1 was revered after ferrostatin-1, liproxstatin-1 (Lip-1) or deferprone (DFP) administration.	deferprone	286-296	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	200-204
32516287-2	2020	We sought to examine whether plasma COX-2 levels and its genetic variants is associated with salt sensitivity, BP changes and/or hypertension in humans.	Salts	93-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-41
32516287-5	2020	RESULTS: Plasma COX-2 levels were significantly decreased with reduction of salt intake from the usual to a low-salt diet and decreased further when converting from the low-salt to the high-salt diet.	Salts	76-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-21
32717439-0	2020	Two isostructural Co(II) flufenamato and niflumato complexes with bathocuproine: Analogues with a different cytotoxic activity.	flufenamato	25-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-24
32516287-5	2020	RESULTS: Plasma COX-2 levels were significantly decreased with reduction of salt intake from the usual to a low-salt diet and decreased further when converting from the low-salt to the high-salt diet.	Salts	112-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-21
32717439-0	2020	Two isostructural Co(II) flufenamato and niflumato complexes with bathocuproine: Analogues with a different cytotoxic activity.	bathocuproine	66-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-24
32717439-1	2020	Two novel Co(II) fenamato complexes containing bathocuproine (bcp), namely [Co(bcp)(flu)2] (1) and [Co(bcp)(nif)2] (2) (flu = flufenamato, nif = niflumato) were synthesized and characterized by elemental analysis, single-crystal X-ray structure analysis as well as absorption and fluorescence spectroscopy.	bathocuproine	47-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-16
32717439-1	2020	Two novel Co(II) fenamato complexes containing bathocuproine (bcp), namely [Co(bcp)(flu)2] (1) and [Co(bcp)(nif)2] (2) (flu = flufenamato, nif = niflumato) were synthesized and characterized by elemental analysis, single-crystal X-ray structure analysis as well as absorption and fluorescence spectroscopy.	bathocuproine	62-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-16
32717439-2	2020	Investigation of their molecular structure revealed that both complexes are isostructural and form analogous complex molecules, with a Co(II) atom hexacoordinated by two nitrogen atoms of bcp and four oxygen atoms of two chelate bonded flu (1) and nif (2) ligands in a distorted octahedral arrangement.	Nitrogen	170-178	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-141
32516287-5	2020	RESULTS: Plasma COX-2 levels were significantly decreased with reduction of salt intake from the usual to a low-salt diet and decreased further when converting from the low-salt to the high-salt diet.	Salts	112-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-21
32516287-6	2020	SNPs rs12042763 in the COX-2 gene was significantly associated with SBP responses to both low-salt and high-salt diet.	Salts	94-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-28
32516287-6	2020	SNPs rs12042763 in the COX-2 gene was significantly associated with SBP responses to both low-salt and high-salt diet.	Salts	108-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-28
32516287-10	2020	CONCLUSION: This study shows that dietary salt intake affects plasma COX-2 levels and that COX-2 may play a role in salt sensitivity, BP progression and development of hypertension in the Chinese populations studied.	Salts	42-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-74
32624377-2	2020	The hypothesis was that patients receiving the TDB patch would have less pain in comparison to those treated with the oral COX-2 inhibitor celecoxib without increasing side effects.	Celecoxib	139-148	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-128
32705205-15	2020	It was also identified that the inhibitory effect of BS on PGE2 production was mediated via the regulation of COX-2.	Dinoprostone	59-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-115
32705218-4	2020	We revealed by MTT and western blotting, respectively, that celecoxib (CCB), an NSAID, and 2,5-dimethyl celecoxib (DMC), a non-cyclooxygenase (COX)-2 inhibitor analog of CCB, were able to sensitize TRAIL-resistant HCC cells to TRAIL, implicating a COX-independent mechanism.	Celecoxib	60-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	143-149
32705218-4	2020	We revealed by MTT and western blotting, respectively, that celecoxib (CCB), an NSAID, and 2,5-dimethyl celecoxib (DMC), a non-cyclooxygenase (COX)-2 inhibitor analog of CCB, were able to sensitize TRAIL-resistant HCC cells to TRAIL, implicating a COX-independent mechanism.	2,5-dimethylcelecoxib	91-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	143-149
32705218-4	2020	We revealed by MTT and western blotting, respectively, that celecoxib (CCB), an NSAID, and 2,5-dimethyl celecoxib (DMC), a non-cyclooxygenase (COX)-2 inhibitor analog of CCB, were able to sensitize TRAIL-resistant HCC cells to TRAIL, implicating a COX-independent mechanism.	2,5-dimethylcelecoxib	115-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	143-149
32789384-0	2020	Co(ii)-Based single-ion magnets with 1,1"-ferrocenediyl-bis(diphenylphosphine) metalloligands.	1,1"-ferrocenediyl-bis(diphenylphosphine)	37-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
32705218-4	2020	We revealed by MTT and western blotting, respectively, that celecoxib (CCB), an NSAID, and 2,5-dimethyl celecoxib (DMC), a non-cyclooxygenase (COX)-2 inhibitor analog of CCB, were able to sensitize TRAIL-resistant HCC cells to TRAIL, implicating a COX-independent mechanism.	Celecoxib	170-173	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	143-149
32512147-0	2020	Cadmium exposure activates Akt/ERK Signaling and pro-inflammatory COX-2 expression in human gallbladder epithelial cells via a ROS dependent mechanism.	Cadmium	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-71
32789384-1	2020	Herein, we report on investigations of magnetic and spectroscopic properties of three heterobimetallic Fe(ii)-Co(ii) coordination compounds based on the tetracoordinate {CoP2X2} core encapsulated by dppf metalloligand, where X = Cl (1), Br (2), I (3), dppf = 1,1"-ferrocenediyl -bis(diphenylphosphine).	1,1'-bis(diphenylphosphino)ferrocene	199-203	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-108
32789384-1	2020	Herein, we report on investigations of magnetic and spectroscopic properties of three heterobimetallic Fe(ii)-Co(ii) coordination compounds based on the tetracoordinate {CoP2X2} core encapsulated by dppf metalloligand, where X = Cl (1), Br (2), I (3), dppf = 1,1"-ferrocenediyl -bis(diphenylphosphine).	1,1'-bis(diphenylphosphino)ferrocene	199-203	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-116
32789384-1	2020	Herein, we report on investigations of magnetic and spectroscopic properties of three heterobimetallic Fe(ii)-Co(ii) coordination compounds based on the tetracoordinate {CoP2X2} core encapsulated by dppf metalloligand, where X = Cl (1), Br (2), I (3), dppf = 1,1"-ferrocenediyl -bis(diphenylphosphine).	cl (1)	229-235	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-108
32789384-1	2020	Herein, we report on investigations of magnetic and spectroscopic properties of three heterobimetallic Fe(ii)-Co(ii) coordination compounds based on the tetracoordinate {CoP2X2} core encapsulated by dppf metalloligand, where X = Cl (1), Br (2), I (3), dppf = 1,1"-ferrocenediyl -bis(diphenylphosphine).	cl (1)	229-235	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-116
32789384-1	2020	Herein, we report on investigations of magnetic and spectroscopic properties of three heterobimetallic Fe(ii)-Co(ii) coordination compounds based on the tetracoordinate {CoP2X2} core encapsulated by dppf metalloligand, where X = Cl (1), Br (2), I (3), dppf = 1,1"-ferrocenediyl -bis(diphenylphosphine).	br (2)	237-243	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-108
32789384-1	2020	Herein, we report on investigations of magnetic and spectroscopic properties of three heterobimetallic Fe(ii)-Co(ii) coordination compounds based on the tetracoordinate {CoP2X2} core encapsulated by dppf metalloligand, where X = Cl (1), Br (2), I (3), dppf = 1,1"-ferrocenediyl -bis(diphenylphosphine).	br (2)	237-243	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-116
32789384-1	2020	Herein, we report on investigations of magnetic and spectroscopic properties of three heterobimetallic Fe(ii)-Co(ii) coordination compounds based on the tetracoordinate {CoP2X2} core encapsulated by dppf metalloligand, where X = Cl (1), Br (2), I (3), dppf = 1,1"-ferrocenediyl -bis(diphenylphosphine).	Iodine	245-246	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-108
32789384-1	2020	Herein, we report on investigations of magnetic and spectroscopic properties of three heterobimetallic Fe(ii)-Co(ii) coordination compounds based on the tetracoordinate {CoP2X2} core encapsulated by dppf metalloligand, where X = Cl (1), Br (2), I (3), dppf = 1,1"-ferrocenediyl -bis(diphenylphosphine).	Iodine	245-246	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-116
32789384-1	2020	Herein, we report on investigations of magnetic and spectroscopic properties of three heterobimetallic Fe(ii)-Co(ii) coordination compounds based on the tetracoordinate {CoP2X2} core encapsulated by dppf metalloligand, where X = Cl (1), Br (2), I (3), dppf = 1,1"-ferrocenediyl -bis(diphenylphosphine).	1,1'-bis(diphenylphosphino)ferrocene	252-256	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-108
32789384-1	2020	Herein, we report on investigations of magnetic and spectroscopic properties of three heterobimetallic Fe(ii)-Co(ii) coordination compounds based on the tetracoordinate {CoP2X2} core encapsulated by dppf metalloligand, where X = Cl (1), Br (2), I (3), dppf = 1,1"-ferrocenediyl -bis(diphenylphosphine).	1,1'-bis(diphenylphosphino)ferrocene	252-256	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-116
32854331-9	2020	In our network, GO and KEGG results yielded two compounds (beta-sitosterol (BS) and pelargonidin (PG)), targets (PTGS1 (COX-1) and PTGS2 (COX-2)), and pathways (nitric oxide, TNF) were involved in the inhibitory effects of FT on influenza-associated inflammation.	gamma-sitosterol	76-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	138-143
32789384-1	2020	Herein, we report on investigations of magnetic and spectroscopic properties of three heterobimetallic Fe(ii)-Co(ii) coordination compounds based on the tetracoordinate {CoP2X2} core encapsulated by dppf metalloligand, where X = Cl (1), Br (2), I (3), dppf = 1,1"-ferrocenediyl -bis(diphenylphosphine).	1,1"-ferrocenediyl -bis(diphenylphosphine	259-300	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-108
32789384-1	2020	Herein, we report on investigations of magnetic and spectroscopic properties of three heterobimetallic Fe(ii)-Co(ii) coordination compounds based on the tetracoordinate {CoP2X2} core encapsulated by dppf metalloligand, where X = Cl (1), Br (2), I (3), dppf = 1,1"-ferrocenediyl -bis(diphenylphosphine).	1,1"-ferrocenediyl -bis(diphenylphosphine	259-300	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-116
32825724-10	2020	Notably, tepotinib significantly reduced the expression of EMT-promoting genes such as MMP7, COX-2, WNT1, MUC5B, and c-MYC in c-MET-amplified GC cells and increased the expression of EMT-suppressing genes such as MUC5AC, MUC6, GSK3beta, and E-cadherin.	EMD1214063	9-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-98
32697905-3	2020	Mechanistic studies suggest that the reaction operates through a radical chain process initiated by Co(II)/O2/phenol and quenched by the cobalt-based catalyst.	Oxygen	107-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-106
32697905-3	2020	Mechanistic studies suggest that the reaction operates through a radical chain process initiated by Co(II)/O2/phenol and quenched by the cobalt-based catalyst.	Phenol	110-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-106
32697905-3	2020	Mechanistic studies suggest that the reaction operates through a radical chain process initiated by Co(II)/O2/phenol and quenched by the cobalt-based catalyst.	Cobalt	137-143	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-106
32794423-1	2021	Novel macrocyclic Schiff base complexes [[ML]X; where M = Cu(II), Co(II), Ni(II), Zn(II), Mn(II) and VO(IV); L = macrocyclic ligand; X = Cl2 and SO4 2-] have been synthesized and characterized by microanalytical, 1H, 13C NMR, IR, Mass, UV-Vis, EPR spectral studies, as well as conductivity data.	Schiff Bases	18-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-72
32672945-8	2020	The superior catalytic activity was due to synergistic effect of metal oxides and O-g-C3N4, in which O-g-C3N4 could act as carrier and activator as well as electron mediator, to promote the conversion of Fe(III) to Fe(II) and Co(III) to Co(II).	metal oxides	65-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	237-243
32672945-8	2020	The superior catalytic activity was due to synergistic effect of metal oxides and O-g-C3N4, in which O-g-C3N4 could act as carrier and activator as well as electron mediator, to promote the conversion of Fe(III) to Fe(II) and Co(III) to Co(II).	o-g-c3n4	82-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	237-243
32672945-8	2020	The superior catalytic activity was due to synergistic effect of metal oxides and O-g-C3N4, in which O-g-C3N4 could act as carrier and activator as well as electron mediator, to promote the conversion of Fe(III) to Fe(II) and Co(III) to Co(II).	o-g-c3n4	101-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	237-243
32672945-8	2020	The superior catalytic activity was due to synergistic effect of metal oxides and O-g-C3N4, in which O-g-C3N4 could act as carrier and activator as well as electron mediator, to promote the conversion of Fe(III) to Fe(II) and Co(III) to Co(II).	ammonium ferrous sulfate	215-221	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	237-243
32485532-2	2020	To that end, a multi-target design strategy was adopted to develop some 1,2,3-triazoles hybridized with some pharmacophoric anticancer fragments, as first-in-class simultaneous inhibitors of COX-2, 15-LOX and tumor associated carbonic anhydrase enzymes.	1,2,3-triazoles	72-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	191-196
32485532-4	2020	COX-2 inhibitory activity was further demonstrated by the inhibition of the accumulation of 6-keto-PGF1alpha, a metabolite of COX-2 products in two cancer cell lines.	6-Ketoprostaglandin F1 alpha	92-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
32485532-4	2020	COX-2 inhibitory activity was further demonstrated by the inhibition of the accumulation of 6-keto-PGF1alpha, a metabolite of COX-2 products in two cancer cell lines.	6-Ketoprostaglandin F1 alpha	92-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-131
32794423-9	2021	Binding interactions and energies of ligand and its metal complexes [ML]2+ (M = VO(IV), Mn(II), Co(II), Ni(II), Cu(II), Zn(II)) against the receptors EGFR and HER2 are performed using the Auto dock module.	Metals	52-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-102
32903536-8	2020	Mechanistically, deletion of GCN2 triggers enhanced production of COX-2/PGE2 through profound activation of Ikappakappa-NF-kappaB signaling pathway.	Dinoprostone	72-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-71
32376366-10	2020	Furthermore, we found that DoA could significantly inhibit IL-1beta-induced inflammation in SW982 human synovial cells, as evidenced by the decreased levels of pro-inflammatory mediators (TNF-alpha, IL-6 and COX-2) and MMP-3.	dioctyl adipate	27-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	208-213
32905529-2	2020	Our recent findings in bladder cancer suggested that activation of prostaglandin receptors (e.g. EP2, EP4) or cyclooxygenase (COX)-2 induced cisplatin resistance.	Cisplatin	141-150	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-132
32767405-3	2020	The mechanism of paracetamol action consists in inhibition of cyclooxygenases (COX-1, COX-2, and COX-3) and involvement in the endocannabinoid system and serotonergic pathways.	Acetaminophen	17-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-91
32697584-1	2020	We have found that terminal N-vinylindoles bearing cycloalkanone substituents are excellent hydrogen atom acceptors, generating alpha-aminyl radicals with a variety of catalysts (Co(II)/H2 or Co(III)Cl precatalysts with silane reductants).	n-vinylindoles	28-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	179-188
32697584-1	2020	We have found that terminal N-vinylindoles bearing cycloalkanone substituents are excellent hydrogen atom acceptors, generating alpha-aminyl radicals with a variety of catalysts (Co(II)/H2 or Co(III)Cl precatalysts with silane reductants).	cycloalkanone	51-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	179-188
32697584-1	2020	We have found that terminal N-vinylindoles bearing cycloalkanone substituents are excellent hydrogen atom acceptors, generating alpha-aminyl radicals with a variety of catalysts (Co(II)/H2 or Co(III)Cl precatalysts with silane reductants).	Hydrogen	92-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	179-188
32697584-1	2020	We have found that terminal N-vinylindoles bearing cycloalkanone substituents are excellent hydrogen atom acceptors, generating alpha-aminyl radicals with a variety of catalysts (Co(II)/H2 or Co(III)Cl precatalysts with silane reductants).	alpha-aminyl radicals	128-149	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	179-188
32850909-11	2020	The inhibition of COX-2 markedly ameliorated UA-induced apoptotic response and PGE2 production in MAECs.	Uric Acid	45-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-23
32850909-11	2020	The inhibition of COX-2 markedly ameliorated UA-induced apoptotic response and PGE2 production in MAECs.	Dinoprostone	79-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-23
32850909-13	2020	Conclusion: We concluded that miR-214 could alleviate UA-induced MAEC apoptosis possibly by inhibiting the COX-2/PGE2 cascade.	Uric Acid	54-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-112
32850909-13	2020	Conclusion: We concluded that miR-214 could alleviate UA-induced MAEC apoptosis possibly by inhibiting the COX-2/PGE2 cascade.	Dinoprostone	113-117	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-112
32905529-10	2020	Moreover, treatment with tamoxifen or a COX-2 inhibitor celecoxib increased cisplatin sensitivity even in resistant cells, while COX-2/EP2/EP4 inhibitor treatment resulted in reduced expression of ERbeta.	Celecoxib	56-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
32905529-10	2020	Moreover, treatment with tamoxifen or a COX-2 inhibitor celecoxib increased cisplatin sensitivity even in resistant cells, while COX-2/EP2/EP4 inhibitor treatment resulted in reduced expression of ERbeta.	Cisplatin	76-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
31420920-0	2020	Aspirin for the prevention and treatment of pre-eclampsia: A matter of COX-1 and/or COX-2 inhibition?	Aspirin	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-89
32599361-5	2020	Both compounds inhibited the cyclooxygenation of arachidonic acid by ovine COX-1, and were more potent inhibitors of human recombinant COX-2 when 2-arachidonoylglycerol was used as substrate than when arachidonic acid was used.	glyceryl 2-arachidonate	146-168	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-140
32535107-1	2020	The most recognized mechanism of aspirin(acetylsalicylic acid, ASA) action, at therapeutic dosing, is the inhibition of prostanoid biosynthesis through the acetylation of cyclooxygenase(COX)-isozymes (COX-1 at serine-529 and COX-2 at serine-516).	Aspirin	33-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	225-230
32535107-1	2020	The most recognized mechanism of aspirin(acetylsalicylic acid, ASA) action, at therapeutic dosing, is the inhibition of prostanoid biosynthesis through the acetylation of cyclooxygenase(COX)-isozymes (COX-1 at serine-529 and COX-2 at serine-516).	Aspirin	41-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	225-230
32535107-1	2020	The most recognized mechanism of aspirin(acetylsalicylic acid, ASA) action, at therapeutic dosing, is the inhibition of prostanoid biosynthesis through the acetylation of cyclooxygenase(COX)-isozymes (COX-1 at serine-529 and COX-2 at serine-516).	Aspirin	63-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	225-230
32535107-2	2020	Whether aspirin, also when given at the low-doses recommended for cardiovascular prevention, reduces the risk of colorectal cancer by affecting COX-2 activity in colorectal adenomatous lesions is still debated.	Aspirin	8-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	144-149
32535107-3	2020	We aimed to develop a direct biomarker of aspirin action on COX-2 by assessing the extent of acetylation of COX-2 at serine-516 using the AQUA strategy, enabling absolute protein quantitation by liquid chromatography-mass spectrometry.	Aspirin	42-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-65
32535107-3	2020	We aimed to develop a direct biomarker of aspirin action on COX-2 by assessing the extent of acetylation of COX-2 at serine-516 using the AQUA strategy, enabling absolute protein quantitation by liquid chromatography-mass spectrometry.	Aspirin	42-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-113
32535107-3	2020	We aimed to develop a direct biomarker of aspirin action on COX-2 by assessing the extent of acetylation of COX-2 at serine-516 using the AQUA strategy, enabling absolute protein quantitation by liquid chromatography-mass spectrometry.	Serine	117-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-65
32535107-3	2020	We aimed to develop a direct biomarker of aspirin action on COX-2 by assessing the extent of acetylation of COX-2 at serine-516 using the AQUA strategy, enabling absolute protein quantitation by liquid chromatography-mass spectrometry.	Serine	117-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-113
32535107-5	2020	Hu-COX-2 exposed in vitro to an excess of ASA was acetylated by approximately 40-50% associated with the inhibition of COX-2 activity by 80-90%.	Aspirin	42-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	3-8
32535107-5	2020	Hu-COX-2 exposed in vitro to an excess of ASA was acetylated by approximately 40-50% associated with the inhibition of COX-2 activity by 80-90%.	Aspirin	42-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-124
32535107-6	2020	In the three cell-types expressing COX-2, the extent of COX-2 acetylation and reduction of prostaglandin (PG)E2 biosynthesis by ASA was concentration-dependent with comparable EC50 values(in the low muM range).	Prostaglandins	91-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40
32535107-6	2020	In the three cell-types expressing COX-2, the extent of COX-2 acetylation and reduction of prostaglandin (PG)E2 biosynthesis by ASA was concentration-dependent with comparable EC50 values(in the low muM range).	Dinoprostone	106-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40
32535107-6	2020	In the three cell-types expressing COX-2, the extent of COX-2 acetylation and reduction of prostaglandin (PG)E2 biosynthesis by ASA was concentration-dependent with comparable EC50 values(in the low muM range).	Aspirin	128-131	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40
32535107-6	2020	In the three cell-types expressing COX-2, the extent of COX-2 acetylation and reduction of prostaglandin (PG)E2 biosynthesis by ASA was concentration-dependent with comparable EC50 values(in the low muM range).	Aspirin	128-131	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-61
32535107-7	2020	The maximal % acetylation of COX-2 averaged 80%, at ASA 1000 muM, and was associated with a virtually complete reduction of PGE2 biosynthesis (97%).	Dinoprostone	124-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34
32535107-8	2020	In conclusion, we have developed a proteomic assay to evaluate the extent of acetylation of COX-2 at serine-516 by aspirin; its use in clinical studies will allow clarifying the mechanism of action of aspirin as anticancer agent.	Serine	101-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-97
32599361-5	2020	Both compounds inhibited the cyclooxygenation of arachidonic acid by ovine COX-1, and were more potent inhibitors of human recombinant COX-2 when 2-arachidonoylglycerol was used as substrate than when arachidonic acid was used.	Arachidonic Acid	201-217	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-140
32535107-8	2020	In conclusion, we have developed a proteomic assay to evaluate the extent of acetylation of COX-2 at serine-516 by aspirin; its use in clinical studies will allow clarifying the mechanism of action of aspirin as anticancer agent.	Aspirin	115-122	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-97
32535107-8	2020	In conclusion, we have developed a proteomic assay to evaluate the extent of acetylation of COX-2 at serine-516 by aspirin; its use in clinical studies will allow clarifying the mechanism of action of aspirin as anticancer agent.	Aspirin	201-208	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-97
32417162-8	2020	Our results showed that STA significantly suppressed IL-1beta-induced inflammation with decreased levels of inflammatory mediators and cytokines including NO, PGE2, iNOS, COX-2, TNF-alpha and IL-6.	stachydrine	24-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	171-176
32464763-8	2020	It was suspected that O2 - and H2O2 played important roles in the formation of  OH and the cycle of Co(II)/Co(III) and Ni(II)/Ni(III).	Oxygen	22-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-106
32464763-8	2020	It was suspected that O2 - and H2O2 played important roles in the formation of  OH and the cycle of Co(II)/Co(III) and Ni(II)/Ni(III).	Hydrogen Peroxide	31-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-106
31884678-3	2020	It is known that COX-2/PGE2 play key roles in the pathogenesis of airway inflammation.	Dinoprostone	23-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22
31884678-6	2020	The objective of the present study was to investigate the regulatory mechanisms of COX-2/PGE2 and Filaggrin upon PM exposure both in vivo and in vitro.	Dinoprostone	89-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
31884678-9	2020	Corresponding dysregulation of COX-2/PGE2 and Filaggrin was also observed in HBECs subjected to PM.	Dinoprostone	37-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-36
31884678-10	2020	PM exposure led to the phosphorylation of ERK, JNK, and PI3K signaling pathways in a time-dependent manner, while blockade of PI3K with the specific molecular inhibitor LY294002 partially reversed the dysregulation of COX-2/PGE2 and Filaggrin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	169-177	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	218-223
32648603-6	2020	AXT also inhibited the induction of COX-2 and IL-6 in human chondrocytes and synovial fibroblasts by western blots.	astaxanthine	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-41
32464763-8	2020	It was suspected that O2 - and H2O2 played important roles in the formation of  OH and the cycle of Co(II)/Co(III) and Ni(II)/Ni(III).	co(iii)	107-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-106
32173897-1	2020	Some novel non-ulcerogenic N-substitutedphenyl-6-oxo-3-phenylpyridazines as COX-2 inhibitors have been developed (Supplementary material Appendix 1).	n-substitutedphenyl-6-oxo-3-phenylpyridazines	27-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-81
32633944-4	2020	The Co(II) complexes are kinetically inert, decomposing slowly even in 1 M aqueous HCl at 80  C. The Co(II) complexes exhibited well-resolved paramagnetically shifted NMR spectra.	Hydrochloric Acid	83-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
30518262-0	2020	(+-) Gancochlearols A and B: cytotoxic and COX-2 inhibitory meroterpenoids from Ganoderma cochlear.	(+-) gancochlearols	0-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
30518262-0	2020	(+-) Gancochlearols A and B: cytotoxic and COX-2 inhibitory meroterpenoids from Ganoderma cochlear.	meroterpenoids	60-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
32505122-5	2020	COX-1 and COX-2 metabolize AA to bioactive eicosanoids.	Eicosanoids	43-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
32633480-0	2020	2D- MOFs with Ni(II), Cu(II) and Co(II) as Efficient Oxygen Evolution Electrocatalysts: Rationalization of Catalytic Performance vs Structure of the MOFs and Potential of the Redox Couples.	Oxygen	53-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-39
32515238-4	2020	The expression of LXRalpha and NF-kappaB were tested by western blot analysis.Results: Treatment of dioscin suppressed the production of PGE2 and NO, as well as the expression of COX-2 and iNOS (their key regulatory genes).	dioscin	100-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	179-184
31302853-0	2020	Synthesis, molecular docking and evaluation of novel sulfonyl hydrazones as anticancer agents and COX-2 inhibitors.	sulfonyl hydrazones	53-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-103
31302853-9	2020	Sulfonylhydrazones was synthesized and N"-[(2-chloro-3-methoxyphenyl)methylidene]-4- methylbenzenesulfonohydrazide (3k) was identified as the most potent anticancer agent and COX-2 inhibitor.	sulfonylhydrazones	0-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	175-180
31302853-9	2020	Sulfonylhydrazones was synthesized and N"-[(2-chloro-3-methoxyphenyl)methylidene]-4- methylbenzenesulfonohydrazide (3k) was identified as the most potent anticancer agent and COX-2 inhibitor.	n"-[(2-chloro-3-methoxyphenyl)methylidene]-4- methylbenzenesulfonohydrazide	39-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	175-180
32603585-4	2020	By reducing Co(III) to Co(II), Spiro-OMeTAD becomes partially oxidized and the film conductivity is initially increased.	beta-methylene thiazole-4-carboxamide adenine dinucleotide	31-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-29
32801693-11	2020	showed the highest COX-2 inhibitory activities, possibly attributable to their substantial contents of terpenoids.	Terpenes	103-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-24
32633944-4	2020	The Co(II) complexes are kinetically inert, decomposing slowly even in 1 M aqueous HCl at 80  C. The Co(II) complexes exhibited well-resolved paramagnetically shifted NMR spectra.	Hydrochloric Acid	83-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-107
32646396-13	2020	In addition, the survival benefit of postdiagnosis aspirin use appeared to be confined to patients with mutated PIK3CA tumors [HR = 0.78, 95%CI(0.50, 0.99)] and was positive for PTGS2 (COX-2) expression [HR = 0.75, 95%CI(0.43, 1.30)].	Aspirin	51-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	185-190
32764881-7	2020	Results: We found that lentinan inhibits the production of pro-inflammatory cytokines, including IL-1beta, TNF-alpha, IL-8 and the secretion of PGE2 and NO, by reducing the expression of COX-2 and iNOS in AGE-challenged chondrocytes.	Dinoprostone	144-148	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	187-192
32361496-0	2020	Efficient removal of triclosan via peroxymonosulfate activated by a ppb level dosage of Co(II) in water: Reaction kinetics, mechanisms and detoxification.	Triclosan	21-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-94
32361496-0	2020	Efficient removal of triclosan via peroxymonosulfate activated by a ppb level dosage of Co(II) in water: Reaction kinetics, mechanisms and detoxification.	peroxymonosulfate	35-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-94
32361496-0	2020	Efficient removal of triclosan via peroxymonosulfate activated by a ppb level dosage of Co(II) in water: Reaction kinetics, mechanisms and detoxification.	Water	98-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-94
32229208-5	2020	In addition, the significance of inserting the Cu(II) ions recognition cavities within the adsorbent matrix was pointed out by performing the adsorption in a multi-ionic solution mixture containing Co(II), Ni(II), Pb(II), Cd(II) and Cu(II) ions and the obtained selectivity coefficients in case of Cu-CIS revealed remarkable selectivity potentials toward the Cu(II) ions compared to NI-CIS.	cu(ii)	47-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	198-204
32229208-5	2020	In addition, the significance of inserting the Cu(II) ions recognition cavities within the adsorbent matrix was pointed out by performing the adsorption in a multi-ionic solution mixture containing Co(II), Ni(II), Pb(II), Cd(II) and Cu(II) ions and the obtained selectivity coefficients in case of Cu-CIS revealed remarkable selectivity potentials toward the Cu(II) ions compared to NI-CIS.	Copper	47-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	198-204
31927051-8	2020	The result showed that nifedipine inhibited the expression of matrix metalloprotein(MMP)-13, interleukin (IL)-1beta, IL-6, tumor necrosis factor (TNF)-alpha, cyclooxygenase (COX)-2, inducible nitric oxide (NO) synthase (iNOS), and prostaglandin E2 (PGE2), as well as reduced ROS production in human OA chondrocytes, which was partially reversed by BR.	Nifedipine	23-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	174-180
32646396-14	2020	CONCLUSIONS: These findings provide further indications that postdiagnosis aspirin use improves overall survival and cancer-specific survival in colorectal cancer, especially for patients who are positive for PTGS2 (COX-2) expression and PIK3CA-mutated tumors.	Aspirin	75-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	216-221
32645833-0	2020	Loss of miR-101-3p Promotes Transmigration of Metastatic Breast Cancer Cells through the Brain Endothelium by Inducing COX-2/MMP1 Signaling.	mir-101-3p	8-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-124
32659957-0	2020	Synthetic Tuning of CoII-Doped Silica Nanoarchitecture Towards Electrochemical Sensing Ability.	Silicon Dioxide	31-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-24
32659957-1	2020	The present work introduces both synthesis of silica nanoparticles doped with CoII ions by means of differently modified microemulsion water-in-oil (w/o) and Stober techniques and characterization of the hybrid nanoparticles (CoII@SiO2) by TEM, DLS, XRD, ICP-EOS, SAXS, UV-Vis, and UV-Vis/DR spectroscopy and electrochemical methods.	Silicon Dioxide	46-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-82
32659957-1	2020	The present work introduces both synthesis of silica nanoparticles doped with CoII ions by means of differently modified microemulsion water-in-oil (w/o) and Stober techniques and characterization of the hybrid nanoparticles (CoII@SiO2) by TEM, DLS, XRD, ICP-EOS, SAXS, UV-Vis, and UV-Vis/DR spectroscopy and electrochemical methods.	Water	135-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-82
32659957-1	2020	The present work introduces both synthesis of silica nanoparticles doped with CoII ions by means of differently modified microemulsion water-in-oil (w/o) and Stober techniques and characterization of the hybrid nanoparticles (CoII@SiO2) by TEM, DLS, XRD, ICP-EOS, SAXS, UV-Vis, and UV-Vis/DR spectroscopy and electrochemical methods.	Oils	144-147	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-82
32659957-3	2020	The UV-Vis/DR spectra of CoII@SiO2 in the range of d-d transitions indicate that Stober synthesis in greater extent than the w/o one stabilizes tetrahedral CoII ions versus the octahedral ions.	Silicon Dioxide	30-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-29
32659957-4	2020	Both cobalt content and homogeneity of the CoII distribution within CoII@SiO2 are greatly influenced by the synthetic technique.	Silicon Dioxide	73-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-47
32659957-4	2020	Both cobalt content and homogeneity of the CoII distribution within CoII@SiO2 are greatly influenced by the synthetic technique.	Silicon Dioxide	73-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-72
32659957-5	2020	The electrochemical behavior of CoII@SiO2 is manifested by one oxidation and two reduction steps, which provide the basis for electrochemical response on glyphosate and HP(O)(OEt)2 with the LOD = 0.1 muM and the linearity within 0.1-80 muM.	Silicon Dioxide	37-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-36
32659957-5	2020	The electrochemical behavior of CoII@SiO2 is manifested by one oxidation and two reduction steps, which provide the basis for electrochemical response on glyphosate and HP(O)(OEt)2 with the LOD = 0.1 muM and the linearity within 0.1-80 muM.	glyphosate	154-164	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-36
32659957-6	2020	The Stober CoII@SiO2 are able to discriminate glyphosate from HP(O)(OEt)2, while the w/o nanoparticles are more efficient but nonselective sensors on the toxicants.	glyphosate	46-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-15
32650602-9	2020	The increase in content of the proinflammatory enzymes, COX-2 and iNOS induced by DSS were also significantly inhibited by NED along with tissue nitrate levels.	dss	82-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-61
32650602-9	2020	The increase in content of the proinflammatory enzymes, COX-2 and iNOS induced by DSS were also significantly inhibited by NED along with tissue nitrate levels.	nerolidol	123-126	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-61
32510942-1	2020	Reaction of the metalloligand IrIII(ppy-COOH)3 and the anisotropic paramagnetic CoII ion under solvothermal conditions resulted in a metal-metalloligand coordination polymer, [CoII3(mu3-O)(mu-OH2){IrIII(ppy-COO)2(ppy-COOH)}2(H2O)4] 2DMF xH2O (I).	iriii(ppy-cooh)	30-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-84
32510942-1	2020	Reaction of the metalloligand IrIII(ppy-COOH)3 and the anisotropic paramagnetic CoII ion under solvothermal conditions resulted in a metal-metalloligand coordination polymer, [CoII3(mu3-O)(mu-OH2){IrIII(ppy-COO)2(ppy-COOH)}2(H2O)4] 2DMF xH2O (I).	metal-metalloligand	133-152	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-84
32579848-1	2020	We report on the synthesis and structural characterization of the cobalt pentanuclear helicate complex from the rigid tetradentate bis(2-pyridyl)-3,5-pyrazolate ligand bpp-, namely, [{CoII(mu-bpp)3}2CoII3(mu3-OH)]3+ (13+), in which a trinuclear {CoII3(mu3-OH)} core is wrapped by two {CoII(mu-bpp)3} units.	cobalt pentanuclear helicate	66-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	184-188
32645833-6	2020	Using a loss-and-gain of function approach, we found that miR-101-3p downregulation increased transmigration of BC cells through the brain endothelium in vitro by inducing COX-2 expression in cancer cells, whereas ectopic restoration of miR-101-3p exerted a metastasis-reducing effect.	mir-101-3p	58-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	172-177
32579848-1	2020	We report on the synthesis and structural characterization of the cobalt pentanuclear helicate complex from the rigid tetradentate bis(2-pyridyl)-3,5-pyrazolate ligand bpp-, namely, [{CoII(mu-bpp)3}2CoII3(mu3-OH)]3+ (13+), in which a trinuclear {CoII3(mu3-OH)} core is wrapped by two {CoII(mu-bpp)3} units.	cobalt pentanuclear helicate	66-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	199-203
32579848-1	2020	We report on the synthesis and structural characterization of the cobalt pentanuclear helicate complex from the rigid tetradentate bis(2-pyridyl)-3,5-pyrazolate ligand bpp-, namely, [{CoII(mu-bpp)3}2CoII3(mu3-OH)]3+ (13+), in which a trinuclear {CoII3(mu3-OH)} core is wrapped by two {CoII(mu-bpp)3} units.	bis(2-pyridyl)-3,5-pyrazolate	131-160	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	184-188
32510942-1	2020	Reaction of the metalloligand IrIII(ppy-COOH)3 and the anisotropic paramagnetic CoII ion under solvothermal conditions resulted in a metal-metalloligand coordination polymer, [CoII3(mu3-O)(mu-OH2){IrIII(ppy-COO)2(ppy-COOH)}2(H2O)4] 2DMF xH2O (I).	Water	225-228	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-84
32645833-7	2020	In regulatory experiments, we found that miR-101-3p mediated its effect by modulating COX-2-MMP1 signaling capable of degrading the inter-endothelial junctions (claudin-5 and VE-cadherin), key components of the brain endothelium.	mir-101-3p	41-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-91
32526144-0	2020	Structural Transformation and Spatial Defect Formation of a Co(II) MOF Triggered by Varied Metal-Center Coordination Configuration.	Metals	91-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-66
32579848-1	2020	We report on the synthesis and structural characterization of the cobalt pentanuclear helicate complex from the rigid tetradentate bis(2-pyridyl)-3,5-pyrazolate ligand bpp-, namely, [{CoII(mu-bpp)3}2CoII3(mu3-OH)]3+ (13+), in which a trinuclear {CoII3(mu3-OH)} core is wrapped by two {CoII(mu-bpp)3} units.	bis(2-pyridyl)-3,5-pyrazolate	131-160	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	199-203
32645833-8	2020	These findings suggest that miR-101-3p plays a critical role in the transmigration of breast cancer cells through the brain endothelium by modulating the COX-2-MMP1 signaling and thus may serve as a therapeutic target that can be exploited to prevent or suppress brain metastasis in human breast cancer.	mir-101-3p	28-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	154-159
32135366-5	2020	The CO32- buffered pH decline to repress metal leakage, and promoted Co(III) reduction into Co(II) to avoid the over-oxidation of catalyst.	co32	4-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-74
32558559-5	2020	The narrow NMR signals of the Co(II), Fe(II), Fe(III), and V(III) derivatives provide resolved 13C,1H couplings.	ferric sulfate	46-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-36
32558559-5	2020	The narrow NMR signals of the Co(II), Fe(II), Fe(III), and V(III) derivatives provide resolved 13C,1H couplings.	Carbon-13	95-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-36
32558559-5	2020	The narrow NMR signals of the Co(II), Fe(II), Fe(III), and V(III) derivatives provide resolved 13C,1H couplings.	Hydrogen	99-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-36
32135366-6	2020	Under the driving of CO32-, the dominated reactive species were switched from  OH/SO4 - to 1O2 accompanying the migration of catalytic center from Co(II) to Co(III).	co32	21-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-153
32135366-6	2020	Under the driving of CO32-, the dominated reactive species were switched from  OH/SO4 - to 1O2 accompanying the migration of catalytic center from Co(II) to Co(III).	sulfuric acid	82-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-153
32135366-6	2020	Under the driving of CO32-, the dominated reactive species were switched from  OH/SO4 - to 1O2 accompanying the migration of catalytic center from Co(II) to Co(III).	CHEBI:63768	91-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-153
32394669-9	2020	We found that vanillic acid increased the levels of cyclin D1 and Cox-2, which are target genes of beta-catenin, and these changes were inhibited by wortmannin.	Vanillic Acid	14-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-71
32386981-5	2020	In vitro enzyme study implied that compound 8h exerted its anti-inflammatory activity through COX-2 inhibition.	8h	44-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-99
32394669-9	2020	We found that vanillic acid increased the levels of cyclin D1 and Cox-2, which are target genes of beta-catenin, and these changes were inhibited by wortmannin.	Wortmannin	149-159	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-71
32884209-0	2020	Molecular docking data of piperine with Bax, Caspase 3, Cox 2 and Caspase 9.	piperine	26-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-61
32306254-1	2020	In the present study, a geopolymer from dolochar ash was synthesized and used for the removal of heavy metal ions such as Co(II), Ni(II), Cd(II), and Pb(II) from the aqueous solution through the adsorption process.	Metals	103-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-128
32455439-10	2020	The risk of gastrointestinal bleeding was also significantly elevated with exposure to a COX-2 inhibitor and warfarin relative to warfarin alone (OR = 1.90, 95% CI: 1.46-2.46).	Warfarin	130-138	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-94
32455439-12	2020	CONCLUSION:  Risk of bleeding is significantly increased among persons taking warfarin and a NSAID or COX-2 inhibitor together as compared with taking warfarin alone.	Warfarin	151-159	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-107
32413626-0	2020	Synthesis, biological evaluation and modeling of hybrids from tetrahydro-1H-pyrazolo[3,4-b]quinolines as dual cholinestrase and COX-2 inhibitors.	tetrahydro-1h-pyrazolo[3,4-b]quinolines	62-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	128-133
32360554-7	2020	Moreover, CID16020046 showed a dose-response suppressive effect on AGEs- induced expression of the major inflammatory mediators, including COX-2 and iNOS, and the production of NO and PGE2.	4-(4-(3-hydroxyphenyl)-3-(4-methylphenyl)-6-oxo-1H,4H,5H,6H-pyrrolo(3,4-c)pyrazol-5-yl)benzoic acid	10-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-144
32388485-6	2020	Furthermore, longifolioside A inhibited the expression of inflammatory mediator genes such as inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 that produce nitric oxide (NO) and prostaglandin E2 (PGE2), respectively.	Longifolioside A	13-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-159
32388485-6	2020	Furthermore, longifolioside A inhibited the expression of inflammatory mediator genes such as inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 that produce nitric oxide (NO) and prostaglandin E2 (PGE2), respectively.	Dinoprostone	195-211	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-159
33680020-1	2020	We report thermal, X-ray diffraction (XRD) and cytotoxicity studies of complexes of fluconazole (FCZ) with Cu (II), Fe(II), Cd(II), Co(II), Ni(II), and Mn(II).	Fluconazole	84-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-138
33680020-1	2020	We report thermal, X-ray diffraction (XRD) and cytotoxicity studies of complexes of fluconazole (FCZ) with Cu (II), Fe(II), Cd(II), Co(II), Ni(II), and Mn(II).	Fluconazole	97-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-138
33680020-5	2020	The Cu(II)-FCZ exhibited significant activity against SNB-19, HCT-15, COLO-205, and KB-3-1 cell lines, while Fe(II)-FCZ and Co(II)-FCZ were found cytotoxic only to KB-3-1 cell line.	cu(ii)-fcz	4-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	124-130
32336667-7	2020	We observed a clear additive effect of O3 and DEE in combination with UV in increasing levels of several oxidative (4HNE, HO-1) and inflammatory (COX2, NF-kappaB) markers and loss of barrier-associated proteins, such as filaggrin and involucrin.	Ozone	39-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	146-150
32259369-2	2020	Herein we make use of the intrinsic radical-type reactivity of cobalt(III)-carbene radical intermediates in the [CoII(TPP)]-catalyzed (TPP = tetraphenylporphyrin) synthesis of two types of 8-membered ring compounds; novel dibenzocyclooctenes and unprecedented monobenzocyclooctadienes.	cobalt(iii)-carbene	63-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-117
32259369-2	2020	Herein we make use of the intrinsic radical-type reactivity of cobalt(III)-carbene radical intermediates in the [CoII(TPP)]-catalyzed (TPP = tetraphenylporphyrin) synthesis of two types of 8-membered ring compounds; novel dibenzocyclooctenes and unprecedented monobenzocyclooctadienes.	tetraphenylporphine sulfonate	118-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-117
32259369-2	2020	Herein we make use of the intrinsic radical-type reactivity of cobalt(III)-carbene radical intermediates in the [CoII(TPP)]-catalyzed (TPP = tetraphenylporphyrin) synthesis of two types of 8-membered ring compounds; novel dibenzocyclooctenes and unprecedented monobenzocyclooctadienes.	tetraphenylporphyrin	141-161	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-117
32259369-2	2020	Herein we make use of the intrinsic radical-type reactivity of cobalt(III)-carbene radical intermediates in the [CoII(TPP)]-catalyzed (TPP = tetraphenylporphyrin) synthesis of two types of 8-membered ring compounds; novel dibenzocyclooctenes and unprecedented monobenzocyclooctadienes.	dibenzocyclooctenes	222-241	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-117
32259369-2	2020	Herein we make use of the intrinsic radical-type reactivity of cobalt(III)-carbene radical intermediates in the [CoII(TPP)]-catalyzed (TPP = tetraphenylporphyrin) synthesis of two types of 8-membered ring compounds; novel dibenzocyclooctenes and unprecedented monobenzocyclooctadienes.	monobenzocyclooctadienes	260-284	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-117
32591592-8	2020	In addition, propranolol attenuated the Akt-dependent survival signal induced by doxorubicin and strongly reduced the activation of the NF-kB/COX-2 pathway, increasing cell sensitivity to docetaxel.	Propranolol	13-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	142-147
32591592-8	2020	In addition, propranolol attenuated the Akt-dependent survival signal induced by doxorubicin and strongly reduced the activation of the NF-kB/COX-2 pathway, increasing cell sensitivity to docetaxel.	Docetaxel	188-197	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	142-147
32456423-5	2020	Unlike (ArL)CoBr(N3(C6H4-p-tBu)), a series of alkyl azide-bound CoII analogues expel N2 only above 60  C, affording paramagnetic intermediates that convert to the corresponding Co-imine complexes via alpha-H-atom abstraction.	n3(c6h4-p-tbu	17-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-68
32583788-5	2020	The inducible nitric oxide synthase (iNOS), cyclooxigenase (COX)-2, tumor growth factor beta 1 (TGF-beta1) are the most efficient enzymes for interacting with sinularin due to its anti-inflammatory activity, while phosphoinositol 3-kinase (PI3K), Akt and mechanistic target of rapamycin (mTOR) for its anticancer effect.	sinularin	159-168	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-66
32478511-7	2020	Four metal-mediated base pairs are observed between the N7 atoms of G and CoII, an interaction that strongly preserves the central junction site.	Metals	5-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-78
32456423-5	2020	Unlike (ArL)CoBr(N3(C6H4-p-tBu)), a series of alkyl azide-bound CoII analogues expel N2 only above 60  C, affording paramagnetic intermediates that convert to the corresponding Co-imine complexes via alpha-H-atom abstraction.	alkyl azide	46-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-68
32456423-5	2020	Unlike (ArL)CoBr(N3(C6H4-p-tBu)), a series of alkyl azide-bound CoII analogues expel N2 only above 60  C, affording paramagnetic intermediates that convert to the corresponding Co-imine complexes via alpha-H-atom abstraction.	Nitrogen	85-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-68
32456423-5	2020	Unlike (ArL)CoBr(N3(C6H4-p-tBu)), a series of alkyl azide-bound CoII analogues expel N2 only above 60  C, affording paramagnetic intermediates that convert to the corresponding Co-imine complexes via alpha-H-atom abstraction.	co-imine	177-185	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-68
32456423-5	2020	Unlike (ArL)CoBr(N3(C6H4-p-tBu)), a series of alkyl azide-bound CoII analogues expel N2 only above 60  C, affording paramagnetic intermediates that convert to the corresponding Co-imine complexes via alpha-H-atom abstraction.	alpha-h	200-207	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-68
32022364-4	2020	Coordination of Co(II) ions into the porphyrin subunit followed by addition of appropriate monodentate nitrogen-based additives to function as axial ligands enable the radical carbene transfer reactions to styrene derivatives to occur exclusively through the cavity of the macrocycle to afford cyclopropane-linked rotaxanes in excellent 95% yield.	Porphyrins	37-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-22
32022364-4	2020	Coordination of Co(II) ions into the porphyrin subunit followed by addition of appropriate monodentate nitrogen-based additives to function as axial ligands enable the radical carbene transfer reactions to styrene derivatives to occur exclusively through the cavity of the macrocycle to afford cyclopropane-linked rotaxanes in excellent 95% yield.	Nitrogen	103-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-22
32022364-4	2020	Coordination of Co(II) ions into the porphyrin subunit followed by addition of appropriate monodentate nitrogen-based additives to function as axial ligands enable the radical carbene transfer reactions to styrene derivatives to occur exclusively through the cavity of the macrocycle to afford cyclopropane-linked rotaxanes in excellent 95% yield.	carbene	176-183	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-22
32022364-4	2020	Coordination of Co(II) ions into the porphyrin subunit followed by addition of appropriate monodentate nitrogen-based additives to function as axial ligands enable the radical carbene transfer reactions to styrene derivatives to occur exclusively through the cavity of the macrocycle to afford cyclopropane-linked rotaxanes in excellent 95% yield.	Styrene	206-213	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-22
32022364-4	2020	Coordination of Co(II) ions into the porphyrin subunit followed by addition of appropriate monodentate nitrogen-based additives to function as axial ligands enable the radical carbene transfer reactions to styrene derivatives to occur exclusively through the cavity of the macrocycle to afford cyclopropane-linked rotaxanes in excellent 95% yield.	cyclopropane	294-306	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-22
32022364-4	2020	Coordination of Co(II) ions into the porphyrin subunit followed by addition of appropriate monodentate nitrogen-based additives to function as axial ligands enable the radical carbene transfer reactions to styrene derivatives to occur exclusively through the cavity of the macrocycle to afford cyclopropane-linked rotaxanes in excellent 95% yield.	Rotaxanes	314-323	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-22
32022364-5	2020	Investigation of the product distribution afforded from the rotaxane assembly reaction reveals how the redox cooperative action between the carbene species and the Co(II) ions can be manipulated to gain control over the radical-type mechanism in order to favor productive rotaxane forming process.	carbene	140-147	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	164-170
32412237-5	2020	Specifically, two scenarios are identified that allow for the production of compressed high-purity CO2 for costs   $300/tCO2, net delivered with an opportunity to scale to 19 MtCO2/yr.	Carbon Dioxide	99-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	175-180
32478346-4	2020	DFT calculations are consistent with two one-electron CoII reductants binding to one NO2- bridge, then proton transfer being needed for facile N/O bond scission.	Nitrogen Dioxide	85-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-58
32432460-8	2020	At regional CO2 collection hubs, emissions of 40 MtCO2/yr can be avoided within 100 miles of the existing Louisiana-Mississippi and Texas-New Mexico pipelines.	Carbon Dioxide	12-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-54
32546278-0	2020	3,3"-Diindolylmethane modulates aryl hydrocarbon receptor of esophageal squamous cell carcinoma to reverse epithelial-mesenchymal transition through repressing RhoA/ROCK1-mediated COX2/PGE2 pathway.	3,3'-diindolylmethane	0-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	180-184
32189464-2	2020	A neutral cobalt(II) complex, [Co II (COO-terpy) 2 ] 4H 2 O ( 1 4H 2 O ), stably formed cavities generated via pi-pi stacking motifs and hydrogen bond networks, resulted in the accommodation of four water molecules.	Cobalt(2+)	10-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-36
32189464-2	2020	A neutral cobalt(II) complex, [Co II (COO-terpy) 2 ] 4H 2 O ( 1 4H 2 O ), stably formed cavities generated via pi-pi stacking motifs and hydrogen bond networks, resulted in the accommodation of four water molecules.	4h	53-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-36
32189464-2	2020	A neutral cobalt(II) complex, [Co II (COO-terpy) 2 ] 4H 2 O ( 1 4H 2 O ), stably formed cavities generated via pi-pi stacking motifs and hydrogen bond networks, resulted in the accommodation of four water molecules.	Hydrogen	137-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-36
32189464-2	2020	A neutral cobalt(II) complex, [Co II (COO-terpy) 2 ] 4H 2 O ( 1 4H 2 O ), stably formed cavities generated via pi-pi stacking motifs and hydrogen bond networks, resulted in the accommodation of four water molecules.	Water	199-204	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-36
32546278-0	2020	3,3"-Diindolylmethane modulates aryl hydrocarbon receptor of esophageal squamous cell carcinoma to reverse epithelial-mesenchymal transition through repressing RhoA/ROCK1-mediated COX2/PGE2 pathway.	Dinoprostone	185-189	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	180-184
32546278-11	2020	DIM could inhibit COX2/PGE2 pathway by targeting AHR, and COX2 selective inhibitor Celecoxib could suppress EMT and metastasis.	3,3'-diindolylmethane	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-22
32546278-11	2020	DIM could inhibit COX2/PGE2 pathway by targeting AHR, and COX2 selective inhibitor Celecoxib could suppress EMT and metastasis.	Celecoxib	83-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-62
32546278-14	2020	WB results showed COX2/PGE2 pathway could be regulated by RhoA/ROCK1 pathway and DIM could inhibit RhoA/ROCK1 pathway through modulation of AHR.	Dinoprostone	23-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-22
32251635-2	2020	Celecoxib, the first selective COX-2 inhibitor, was approved by the Food and Drug Administration (FDA) in December 1998 and was taken back from the market in 2004.	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-36
32489100-1	2020	Heteromultimetallic complexes consisting of three Co(II) ions and one lanthanide ion were synthesized and applied to the alternating copolymerization of CO2 and cyclohexene oxide.	Carbon Dioxide	153-156	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-56
32489100-1	2020	Heteromultimetallic complexes consisting of three Co(II) ions and one lanthanide ion were synthesized and applied to the alternating copolymerization of CO2 and cyclohexene oxide.	cyclohexene oxide	161-178	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-56
32545325-5	2020	This study shows the novel ability of OC to suppress LC progression and metastasis through dual targeting of c-MET and COX-2.	oleocanthal	38-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-124
32406437-4	2020	The solid-state reaction yielded 3D coordination polymers [M(tcnopr3OH)2] (M = NiII and CoII) based on a N,N",O-connected tcnopr3OH-.	tcnopr3oh	61-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-92
32406437-4	2020	The solid-state reaction yielded 3D coordination polymers [M(tcnopr3OH)2] (M = NiII and CoII) based on a N,N",O-connected tcnopr3OH-.	tcnopr3oh	122-131	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-92
32606775-0	2020	Eicosapentaenoic acid"s metabolism of 15-LOX-1 promotes the expression of miR-101 thus inhibits Cox2 pathway in colon cancer.	Eicosapentaenoic Acid	0-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-100
32606775-0	2020	Eicosapentaenoic acid"s metabolism of 15-LOX-1 promotes the expression of miR-101 thus inhibits Cox2 pathway in colon cancer.	mir-101	74-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-100
32606775-6	2020	After application of miR-101 mimics in CC cell lines, the Cox2 expression was inhibited too.	mir-101	21-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-62
32606775-9	2020	Conclusion: Our data demonstrate that the EPA-15-LOX-1-miR-101-Cox2 signaling pathway owns a crucial position in the pathogenesis and development of diet-related CC.	Eicosapentaenoic Acid	42-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-67
32545836-9	2020	Furthermore, resveratrol nanofibers suppressed particulate matter (PM)-induced expression of inflammatory proteins (COX-2 and MMP-9) in HaCaT keratinocytes.	Resveratrol	13-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-121
32606658-1	2020	Aim: Etoricoxib is a selective inhibitor of COX-2 enzyme.	Etoricoxib	5-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-49
32420829-0	2021	Effectiveness of toluene mineralisation by gas phase oxidation over Co(II)/SiO2 catalyst with ozone.	Toluene	17-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-74
32438315-5	2020	The endogenous reduction of mc-COX2 can affect mitochondrial functions, suppress cell proliferation, and induce cell apoptosis.	Methylcholanthrene	28-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-35
32438315-8	2020	We also screened and tested several chemical compounds and small-molecule inhibitors that can decrease the generation of mc-COX2.	Methylcholanthrene	121-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	124-128
32438315-9	2020	It was found that the silencing of mc-COX2 in CLL cells strengthened the anti-tumor effects of drugs used in coordination.	Methylcholanthrene	35-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-42
32420829-8	2021	The mechanism involves the formation of  OH radicals, which may explain the effectiveness of Co(II)/ SiO2 catalyst in combination with ozone for the oxidation of toluene andother aromatic VOCsin a low-temperature process.	oh radicals	41-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-99
32420829-0	2021	Effectiveness of toluene mineralisation by gas phase oxidation over Co(II)/SiO2 catalyst with ozone.	Ozone	94-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-74
32420829-8	2021	The mechanism involves the formation of  OH radicals, which may explain the effectiveness of Co(II)/ SiO2 catalyst in combination with ozone for the oxidation of toluene andother aromatic VOCsin a low-temperature process.	Silicon Dioxide	101-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-99
32420829-8	2021	The mechanism involves the formation of  OH radicals, which may explain the effectiveness of Co(II)/ SiO2 catalyst in combination with ozone for the oxidation of toluene andother aromatic VOCsin a low-temperature process.	Toluene	162-169	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-99
32420829-1	2021	The results of experimental study on effectiveness of gas phase total oxidation of toluene towards carbon dioxide and water with the aid of ozone over Co(II)/ SiO2 catalyst are presented in this work.	Toluene	83-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-157
32420829-1	2021	The results of experimental study on effectiveness of gas phase total oxidation of toluene towards carbon dioxide and water with the aid of ozone over Co(II)/ SiO2 catalyst are presented in this work.	Carbon Dioxide	99-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-157
32420829-1	2021	The results of experimental study on effectiveness of gas phase total oxidation of toluene towards carbon dioxide and water with the aid of ozone over Co(II)/ SiO2 catalyst are presented in this work.	Water	118-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-157
32420829-1	2021	The results of experimental study on effectiveness of gas phase total oxidation of toluene towards carbon dioxide and water with the aid of ozone over Co(II)/ SiO2 catalyst are presented in this work.	Ozone	140-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-157
32420829-1	2021	The results of experimental study on effectiveness of gas phase total oxidation of toluene towards carbon dioxide and water with the aid of ozone over Co(II)/ SiO2 catalyst are presented in this work.	Silicon Dioxide	159-163	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-157
32484604-0	2020	Corrigendum: Entrapment of a Pseudo-Tetrahedral CoII Center by Thioether Sulfur Bound {Co2 (mu-L)} Fragments: Synthesis, Field-Induced Single-Ion Magnetism and Catechol Oxidase Mimicking Activity.	thioether sulfur	63-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-52
32484604-0	2020	Corrigendum: Entrapment of a Pseudo-Tetrahedral CoII Center by Thioether Sulfur Bound {Co2 (mu-L)} Fragments: Synthesis, Field-Induced Single-Ion Magnetism and Catechol Oxidase Mimicking Activity.	Carbon Dioxide	87-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-52
31934887-5	2020	MAIN RESULTS: When compared with untreated cells, parecoxib led to a marked decrease in cell viability/proliferation, in COX-2 expression and changes in cell morphology, in a concentration-dependent manner.	parecoxib	50-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-126
33855574-1	2020	A multielement preconcentration procedure based Fe3O4 magnetic nanoparticles coated with polythiophene(Fe3O4@PTh MNPs) as a solid phase was reported for Cu(II), Co(II), Cd(II), Ni(II) and Zn(II) ions.	ferryl iron	48-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	161-167
33855574-1	2020	A multielement preconcentration procedure based Fe3O4 magnetic nanoparticles coated with polythiophene(Fe3O4@PTh MNPs) as a solid phase was reported for Cu(II), Co(II), Cd(II), Ni(II) and Zn(II) ions.	polythiophene	89-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	161-167
33855574-1	2020	A multielement preconcentration procedure based Fe3O4 magnetic nanoparticles coated with polythiophene(Fe3O4@PTh MNPs) as a solid phase was reported for Cu(II), Co(II), Cd(II), Ni(II) and Zn(II) ions.	ferryl iron	103-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	161-167
32058033-12	2020	Both EPA and DHA (50 muM) significantly decreased cyclooxygenase (COX)-2 protein.	Eicosapentaenoic Acid	5-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-72
32363546-0	2020	COX-2-PGE2-EPs in gynecological cancers.	Dinoprostone	6-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
32363546-3	2020	The signaling of cyclooxygenase 2-prostaglandin E2-prostaglandin E2 receptors (COX-2-PGE2-EPs) is the central inflammatory pathway involved in the gynecological carcinogenesis.	2-prostaglandin e2-prostaglandin e2	32-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-84
32363546-3	2020	The signaling of cyclooxygenase 2-prostaglandin E2-prostaglandin E2 receptors (COX-2-PGE2-EPs) is the central inflammatory pathway involved in the gynecological carcinogenesis.	pge2-eps	85-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-84
32363546-4	2020	METHODS: Literature searches were performed to the function of COX-2-PGE2-EPs in gynecological malignancies.	Dinoprostone	69-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-68
32363546-5	2020	RESULTS: This review provides an overview of the current knowledge of COX-2-PGE2-EPs signaling in endometrial cancer, ovarian cancer and cervical cancer.	pge2-eps	76-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-75
32058033-12	2020	Both EPA and DHA (50 muM) significantly decreased cyclooxygenase (COX)-2 protein.	Docosahexaenoic Acids	13-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-72
32278513-0	2020	Screening of chalcone analogs with anti-depressant, anti-inflammatory, analgesic, and COX-2-inhibiting effects.	Chalcone	13-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-91
32193288-3	2020	Cancer-associated fibroblasts (CAF) underwent transcriptional upregulation of COX2 and type I collagen (Col-I), which subsequently triggered a slow-to-active cycling switch in SCC through prostaglandin E2 (PGE2)- and integrin/Src-mediated signaling pathways, leading to cancer progression.	Dinoprostone	188-204	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-82
32193288-3	2020	Cancer-associated fibroblasts (CAF) underwent transcriptional upregulation of COX2 and type I collagen (Col-I), which subsequently triggered a slow-to-active cycling switch in SCC through prostaglandin E2 (PGE2)- and integrin/Src-mediated signaling pathways, leading to cancer progression.	Dinoprostone	206-210	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-82
32084424-2	2020	We investigated whether inflammatory molecules, such as histamine and proteases, activate prostaglandin-endoperoxide synthase 2 (PTGS2, also called COX2) to increase the synthesis of prostaglandin E2 (PGE2) by mast cells, which activates the receptor PTGER2 (also called EP2) in the dorsal root ganglia to promote visceral hypersensitivity.	Dinoprostone	183-199	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	148-152
32305648-11	2020	Significant SPD tuning of the H2O2-dependent induction of degradative (MMP-13) inflammatory (iNOS, COX-2) and hypertrophy markers (Runx 2 and VEGF) was revealed by Real Time PCR and pointed at the SPD ability of reducing NF-kappaB activation through autophagy induction.	Hydrogen Peroxide	30-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-104
32084424-2	2020	We investigated whether inflammatory molecules, such as histamine and proteases, activate prostaglandin-endoperoxide synthase 2 (PTGS2, also called COX2) to increase the synthesis of prostaglandin E2 (PGE2) by mast cells, which activates the receptor PTGER2 (also called EP2) in the dorsal root ganglia to promote visceral hypersensitivity.	Dinoprostone	201-205	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	148-152
32508354-11	2020	Some literatures state that COX-2 inhibitors might play a synergistic role in adjuvant chemotherapy of FOLFOX regimen.	Folfox protocol	103-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
32412746-1	2020	One-dimensional coordination polymers constructed with the 4d metallo-ligand [Mo(NCS)6]3- associated with NiII and CoII complexes are reported.	Polymers	29-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-119
32391690-1	2020	Three mononuclear octahedral Co(II) complexes are reported, [Co(py)4(SCN)2] (1), [Co(py)4(Cl)2] H2O (2), and [Co(py)4(Br)2] (3), that exhibit different distortions with compression (1) or elongation (2 and 3) of the axial positions.	Water	96-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-35
32234671-5	2020	The results revealed that CCGA dose-dependently inhibited LPS-induced production of NO, TNF-alpha, and IL-6 and blocked iNOS, COX-2, TNF-alpha, and IL-6 expressions.	ccga	26-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-131
32412746-5	2020	The soft character of the S atom was also the key to a rare example of a compound involving both high-spin and low-spin CoII centers associated with [Mo(NCS)6].	Sulfur	26-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-124
32391690-1	2020	Three mononuclear octahedral Co(II) complexes are reported, [Co(py)4(SCN)2] (1), [Co(py)4(Cl)2] H2O (2), and [Co(py)4(Br)2] (3), that exhibit different distortions with compression (1) or elongation (2 and 3) of the axial positions.	co(py)4(br)2]	110-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-35
32432869-1	2020	The homodinuclear CoII helicate complex [CoII(DQPD)]2 (1) was prepared by treating [Co(H2O)6](ClO4)2 with the deprotonated form of the ligand N2,N6-bis(quinolin-8-yl)pyridine-2,6-dicarboxamide (DQPDH2).	Water	87-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-22
32432869-1	2020	The homodinuclear CoII helicate complex [CoII(DQPD)]2 (1) was prepared by treating [Co(H2O)6](ClO4)2 with the deprotonated form of the ligand N2,N6-bis(quinolin-8-yl)pyridine-2,6-dicarboxamide (DQPDH2).	Water	87-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-45
32432869-1	2020	The homodinuclear CoII helicate complex [CoII(DQPD)]2 (1) was prepared by treating [Co(H2O)6](ClO4)2 with the deprotonated form of the ligand N2,N6-bis(quinolin-8-yl)pyridine-2,6-dicarboxamide (DQPDH2).	n2,n6-bis(quinolin-8-yl)pyridine-2,6-dicarboxamide	142-192	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-22
32432869-1	2020	The homodinuclear CoII helicate complex [CoII(DQPD)]2 (1) was prepared by treating [Co(H2O)6](ClO4)2 with the deprotonated form of the ligand N2,N6-bis(quinolin-8-yl)pyridine-2,6-dicarboxamide (DQPDH2).	n2,n6-bis(quinolin-8-yl)pyridine-2,6-dicarboxamide	142-192	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-45
32432869-1	2020	The homodinuclear CoII helicate complex [CoII(DQPD)]2 (1) was prepared by treating [Co(H2O)6](ClO4)2 with the deprotonated form of the ligand N2,N6-bis(quinolin-8-yl)pyridine-2,6-dicarboxamide (DQPDH2).	dqpdh2	194-200	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-22
32432869-1	2020	The homodinuclear CoII helicate complex [CoII(DQPD)]2 (1) was prepared by treating [Co(H2O)6](ClO4)2 with the deprotonated form of the ligand N2,N6-bis(quinolin-8-yl)pyridine-2,6-dicarboxamide (DQPDH2).	dqpdh2	194-200	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-45
32432869-3	2020	Complex 1, upon treatment with H2O2, undergoes oxidation at one of the CoII centers followed by a structural deformation to generate the mixed-valence complex [CoIIICoII(DQPD)2](ClO4) (2 ClO4).	Hydrogen Peroxide	31-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-75
32487224-10	2020	Meanwhile, the COX-2/PGE2/EP4 signaling pathway was found to be involved in the inflammatory response and the formation of fibroblasts.	Dinoprostone	21-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-20
31925646-0	2020	Modulation of aryl hydrocarbon receptor inhibits esophageal squamous cell carcinoma progression by repressing COX2/PGE2/STAT3 axis.	Dinoprostone	115-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-114
31925646-8	2020	Our findings also indicated that repressing COX2/PGE2/STAT3 axis exerted inhibitory effects on ESCC both in vitro and in vivo assays.	Dinoprostone	49-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-48
32589073-1	2020	OBJECTIVES: Celecoxib is a selective cyclooxygenase (COX)-2 inhibitor that is commonly used to reduce the incidence of gastrointestinal (GI) complications in patients with rheumatoid arthritis (RA).	Celecoxib	12-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-59
30580627-0	2020	Novel betulin derivatives inhibit IFN-gamma and modulates COX-2 expression.	betulin	6-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
30580627-3	2020	Among these BE derivatives, two (2a e 2c) were able to significantly decrease IFN-g (*p = 0.0391; **p = 0.0156) and 2c modulated the expression of COX-2 better than Dexamethasone (DEXA).	Dexamethasone	180-184	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-152
30580627-6	2020	The presence of chorine in BE seems to be important for the ability of modulate COX-2 expression, since the ester chloride derivative 2c at 100 muM is more powerful inhibitor of COX-2 than DEXA.	chorine	16-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-85
30580627-6	2020	The presence of chorine in BE seems to be important for the ability of modulate COX-2 expression, since the ester chloride derivative 2c at 100 muM is more powerful inhibitor of COX-2 than DEXA.	chorine	16-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	178-183
30580627-6	2020	The presence of chorine in BE seems to be important for the ability of modulate COX-2 expression, since the ester chloride derivative 2c at 100 muM is more powerful inhibitor of COX-2 than DEXA.	betulin	27-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-85
30580627-6	2020	The presence of chorine in BE seems to be important for the ability of modulate COX-2 expression, since the ester chloride derivative 2c at 100 muM is more powerful inhibitor of COX-2 than DEXA.	ester chloride	108-122	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-85
30580627-6	2020	The presence of chorine in BE seems to be important for the ability of modulate COX-2 expression, since the ester chloride derivative 2c at 100 muM is more powerful inhibitor of COX-2 than DEXA.	ester chloride	108-122	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	178-183
30580627-6	2020	The presence of chorine in BE seems to be important for the ability of modulate COX-2 expression, since the ester chloride derivative 2c at 100 muM is more powerful inhibitor of COX-2 than DEXA.	Dexamethasone	189-193	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-85
32198705-8	2020	Notably, pinitol prevents the production of NO and PGE2 by inhibiting the expression of iNOS and COX-2.	pinitol	9-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
32222545-7	2020	The reaction of Br  with DOM can hardly produce organic brominated byproducts, while their formation is mainly due to the bromination of HOBr/OBr- generated through nonradical pathways such as the direct reaction of Br- with oxidants (e.g., peroxymonosulfate (PMS)) or other reactive species derived from catalytic activators (e.g., Co(III) in the Co(II)/PMS process).	Bromine	16-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	348-354
31981603-0	2020	Natural triterpenoid saponin Momordin Ic suppresses HepG2 cell invasion via COX-2 inhibition and PPARgamma activation.	Triterpenes	8-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-81
31981603-0	2020	Natural triterpenoid saponin Momordin Ic suppresses HepG2 cell invasion via COX-2 inhibition and PPARgamma activation.	saponin momordin ic	21-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-81
32485892-1	2020	Four new complexes derived from adamantly containing hydrazone (APH) ligand with Cu(II) (1), Co(II) (2), Ni(II) (3) and Zn(II) (4), have been synthesized and characterized using different physicochemical methods.	adamantly	32-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-99
32481699-8	2020	The combined effect of pH, metal complexation capacity, and the presence of Fe and Mn oxides added to wheat straw biochar resulted in an effective reduction of soluble Co (II), showing high efficiency of this material for cobalt sorption in contaminated soils.	Iron	76-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	168-175
32481699-8	2020	The combined effect of pH, metal complexation capacity, and the presence of Fe and Mn oxides added to wheat straw biochar resulted in an effective reduction of soluble Co (II), showing high efficiency of this material for cobalt sorption in contaminated soils.	mn oxides	83-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	168-175
32481699-8	2020	The combined effect of pH, metal complexation capacity, and the presence of Fe and Mn oxides added to wheat straw biochar resulted in an effective reduction of soluble Co (II), showing high efficiency of this material for cobalt sorption in contaminated soils.	Cobalt	222-228	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	168-175
32518694-8	2020	One of the inflammatory proteins that was identified to be induced by BK treatment is Prostaglandin (PG) H Synthase-2 (Cyclooxygenase-2, COX-2).	prostaglandin (pg	86-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-142
32518694-9	2020	In addition, BK significantly induced the production and release of PGE2 and this effect was inhibited by both COX-2 and MEK Kinase inhibitors, demonstrating that the production of PGE2 by BK is mediated via COX-2 and MAPK-dependent mechanisms.	Dinoprostone	68-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	111-116
32518694-9	2020	In addition, BK significantly induced the production and release of PGE2 and this effect was inhibited by both COX-2 and MEK Kinase inhibitors, demonstrating that the production of PGE2 by BK is mediated via COX-2 and MAPK-dependent mechanisms.	Dinoprostone	181-185	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	111-116
32518694-9	2020	In addition, BK significantly induced the production and release of PGE2 and this effect was inhibited by both COX-2 and MEK Kinase inhibitors, demonstrating that the production of PGE2 by BK is mediated via COX-2 and MAPK-dependent mechanisms.	Dinoprostone	181-185	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	208-213
32596281-1	2020	Celecoxib (CXB) is a COX-2-selective nonsteroidal anti-inflammatory drug used to control pain and various inflammatory conditions.	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-26
32596281-1	2020	Celecoxib (CXB) is a COX-2-selective nonsteroidal anti-inflammatory drug used to control pain and various inflammatory conditions.	Celecoxib	11-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-26
32485892-1	2020	Four new complexes derived from adamantly containing hydrazone (APH) ligand with Cu(II) (1), Co(II) (2), Ni(II) (3) and Zn(II) (4), have been synthesized and characterized using different physicochemical methods.	Hydrazones	53-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-99
32329759-0	2020	Synthesis, structural characterization and electrochemical and magnetic studies of M(hfac)2 (M = CuII, CoII) and Nd(hfac)3 complexes of 4-amino-TEMPO.	4-amino-tempo	136-149	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-107
32525823-10	2020	Dex also recovered the levels of NF-kappaB and COX2, as well as mnSOD, catalase and ROS.	Dexmedetomidine	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-51
32312397-2	2020	In the extraction of Mn(II), Co(II), Ni(II), Tb(III) and Dy(III), the compositions of the extracted metal complexes were determined from the measurements of the magnetophoretic velocity of a single droplet as a function of the mole ratio of the metal ion and the ligand.	Metals	100-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-35
32279495-1	2020	A microscopic approach to the problem of charge transfer induced spin transitions in a system of interacting trinuclear Fe-Co-Fe clusters, which takes into account the switching of polarization during the transformation ls Fe(II)-ls Co(III) -ls Fe(III) -> ls Fe(III)-hs Co(II) -ls Fe(III) (ls - low-spin, hs - how-spin) has been developed.	fe-co-fe	120-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	270-276
32370749-11	2020	Additionally, levels of cyclooxygenase (COX)-2 and the downstream product prostaglandin E2 (PGE2) up-regulated by IAV infection were dramatically suppressed by sinensetin.	Dinoprostone	92-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-46
32370749-11	2020	Additionally, levels of cyclooxygenase (COX)-2 and the downstream product prostaglandin E2 (PGE2) up-regulated by IAV infection were dramatically suppressed by sinensetin.	sinensetin	160-170	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-46
31874761-2	2020	For comparison, and to justify the grafting of BPED groups onto the GO sheets, the GO-based material obtained after each step was used as a solid phase adsorbent for removing Cu(II), Ni(II) and Co(II) metal ions from aqueous solutions.	Metals	201-206	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	194-200
31874761-4	2020	Additionally, it was demonstrated that the equilibrium adsorption capacities of these metal ions followed the order of Cu(II)>Ni(II)>Co(II) whatever the GO-based adsorbent.	Metals	86-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	133-139
32004530-3	2020	Prostaglandin E2 (PGE2), along with its precursor cyclooxygenase (COX)-2, plays an integral role in the pathogenesis of OA and is highly upregulated in response to AGEs.	Dinoprostone	0-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-72
32004530-3	2020	Prostaglandin E2 (PGE2), along with its precursor cyclooxygenase (COX)-2, plays an integral role in the pathogenesis of OA and is highly upregulated in response to AGEs.	Dinoprostone	18-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-72
32338258-0	2020	Bulky Schiff-base ligand supported Co(ii) single-ion magnets with zero-field slow magnetic relaxation.	Schiff Bases	6-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-41
32338258-1	2020	Two mononuclear Co(ii) complexes with tetrahedral coordination geometry have been constructed from different bulky Schiff-base ligands.	Schiff Bases	115-126	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-22
32271545-5	2020	The possible interface mechanism of PMS activation by CuCo-H3 was proposed, wherein unique interconnected meso-macroporous nanosheets structure, strong interaction between copper and cobalt, and cycling of Co(II)/Co(III) and Cu(I)/Cu(II) effectively facilitated PMS activation to generate SO4 - and  OH, which contributed to BP-4 degradation.	cuco-h3	54-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	206-212
32271545-5	2020	The possible interface mechanism of PMS activation by CuCo-H3 was proposed, wherein unique interconnected meso-macroporous nanosheets structure, strong interaction between copper and cobalt, and cycling of Co(II)/Co(III) and Cu(I)/Cu(II) effectively facilitated PMS activation to generate SO4 - and  OH, which contributed to BP-4 degradation.	Copper	172-178	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	206-212
32271545-5	2020	The possible interface mechanism of PMS activation by CuCo-H3 was proposed, wherein unique interconnected meso-macroporous nanosheets structure, strong interaction between copper and cobalt, and cycling of Co(II)/Co(III) and Cu(I)/Cu(II) effectively facilitated PMS activation to generate SO4 - and  OH, which contributed to BP-4 degradation.	Cobalt	183-189	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	206-212
32271545-5	2020	The possible interface mechanism of PMS activation by CuCo-H3 was proposed, wherein unique interconnected meso-macroporous nanosheets structure, strong interaction between copper and cobalt, and cycling of Co(II)/Co(III) and Cu(I)/Cu(II) effectively facilitated PMS activation to generate SO4 - and  OH, which contributed to BP-4 degradation.	cu(ii)	231-237	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	206-212
32271545-5	2020	The possible interface mechanism of PMS activation by CuCo-H3 was proposed, wherein unique interconnected meso-macroporous nanosheets structure, strong interaction between copper and cobalt, and cycling of Co(II)/Co(III) and Cu(I)/Cu(II) effectively facilitated PMS activation to generate SO4 - and  OH, which contributed to BP-4 degradation.	sulfuric acid	289-292	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	206-212
32455205-4	2020	The adsorption capacity was 18 mg Co(II) per gram of dry adsorbent at room temperature (22  C) at near-neutral pH, three times higher than that of the summarized capacity of lignin or silica starting materials.	Lignin	174-180	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-40
32250753-0	2020	Nano-manganese oxide-functionalized-oleyl amine as a simple and low cost nanosorbent for remediation of ZnII/CoII and their radioactive nuclides 65Zn and 60Co from water.	manganese oxide	5-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-113
32250753-0	2020	Nano-manganese oxide-functionalized-oleyl amine as a simple and low cost nanosorbent for remediation of ZnII/CoII and their radioactive nuclides 65Zn and 60Co from water.	oleylamine	36-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-113
32250753-0	2020	Nano-manganese oxide-functionalized-oleyl amine as a simple and low cost nanosorbent for remediation of ZnII/CoII and their radioactive nuclides 65Zn and 60Co from water.	nuclides	136-144	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-113
32250753-0	2020	Nano-manganese oxide-functionalized-oleyl amine as a simple and low cost nanosorbent for remediation of ZnII/CoII and their radioactive nuclides 65Zn and 60Co from water.	Water	164-169	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-113
32250753-4	2020	The influence of diverse parameters on remediation of ZnII/CoII was examined, involving pH of metal ion solutions (pH 1-7), reaction time (1-60 min), solid amount (5-100 mg) and ionic concentration (0.1-2.0 mol/L).	Metals	94-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-63
32205045-5	2020	Therefore, in the present investigation a series of 1,2-diphenylbenzimidazoles (DPBI) with different aromatic substitutions in the para position were synthesized and their interaction with COX-2 and nitric oxide synthase, iNOS, was determined in silico, in vitro and in vivo.	1,2-diphenylbenzimidazoles	52-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	189-194
32205045-5	2020	Therefore, in the present investigation a series of 1,2-diphenylbenzimidazoles (DPBI) with different aromatic substitutions in the para position were synthesized and their interaction with COX-2 and nitric oxide synthase, iNOS, was determined in silico, in vitro and in vivo.	dpbi	80-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	189-194
32124251-4	2020	Curcumin treatment inhibited the expression of the inflammation mediators IL-6, iNOS, and COX-2 and of the matrix-degrading proteinases MMP-1, MMP-3, MMP-9, MMP-13, ADAMTS-4, and ADAMTS-5 and upregulated the mRNA levels of the cartilage anabolic factors COL2A1 and ACAN after IL-1beta treatment.	Curcumin	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-95
32159561-1	2020	Four bimetallic phases of the thiophosphate family have been synthesized by the cationic exchange reaction using a freshly prepared K0.5Cd0.75PS3 precursor phase and methanolic solutions of nitrates of the divalent cations ZnII, NiII, CoII, and MnII.	thiophosphoric acid	30-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	235-239
32346326-3	2020	The requisite spiroindolone analogues were tested for their potential inhibitory activities against lipid metabolizing enzymes such as cyclooxygenase COX-1, COX-2, and the release of pro-inflammatory cytokines interleukin IL-6, and tumor necrosis factor TNF-alpha.	spiroindolone	14-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	157-162
32155075-3	2020	The MPN coatings were self-assembled from metal ions (FeIII, CoII, CuII, NiII, or ZnII) cross-linked with tannic acid.	N-nitrosomethyl-N-propylamine	4-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-65
32354131-6	2020	The DOX-stimulated expression of IkappaBalpha, NF-kappaB, COX-2, and IL-8 were all downregulated by exercise as well as the fibrosis factors (TGF-beta1, phosphorylated ERK, Sp1, and CTGF).	Doxorubicin	4-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
32030858-3	2020	The microgel assemblies, which are controlled by monitoring the attractive and repulsive potentials between the soft colloidal particles are then frozen by forming inter-particles metal-terpyridine bis-complexes upon addition of the metallic cation (Fe II , Co II , ...).	2,2',2''-terpyridine	180-201	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	258-263
32357521-7	2020	TC-E dramatically reduced lipopolysaccharide (LPS)-induced NO production and the expression of inflammatory genes (inducible NO synthase (iNOS), cyclooxygenase (COX)-2, tumor necrosis factor (TNF)-alpha and interleukin (IL)-6) as determined using RT-PCR.	Trichloroethylene	0-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-167
32186188-2	2020	Co(II) or Co(III) can activate PAA to produce acetyloxyl (CH3C(O)O ) and acetylperoxyl (CH3C(O)OO ) radicals with little  OH radical formation, and Co(II)/Co(III) is cycled.	Peracetic Acid	31-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
32186188-2	2020	Co(II) or Co(III) can activate PAA to produce acetyloxyl (CH3C(O)O ) and acetylperoxyl (CH3C(O)OO ) radicals with little  OH radical formation, and Co(II)/Co(III) is cycled.	Peracetic Acid	31-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	148-154
32186188-2	2020	Co(II) or Co(III) can activate PAA to produce acetyloxyl (CH3C(O)O ) and acetylperoxyl (CH3C(O)OO ) radicals with little  OH radical formation, and Co(II)/Co(III) is cycled.	acetyloxyl	46-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
32186188-2	2020	Co(II) or Co(III) can activate PAA to produce acetyloxyl (CH3C(O)O ) and acetylperoxyl (CH3C(O)OO ) radicals with little  OH radical formation, and Co(II)/Co(III) is cycled.	ch3c	58-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
32186188-2	2020	Co(II) or Co(III) can activate PAA to produce acetyloxyl (CH3C(O)O ) and acetylperoxyl (CH3C(O)OO ) radicals with little  OH radical formation, and Co(II)/Co(III) is cycled.	Oxygen	63-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
32186188-2	2020	Co(II) or Co(III) can activate PAA to produce acetyloxyl (CH3C(O)O ) and acetylperoxyl (CH3C(O)OO ) radicals with little  OH radical formation, and Co(II)/Co(III) is cycled.	acetylperoxyl (ch3c(o)oo ) radicals	73-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
32186188-2	2020	Co(II) or Co(III) can activate PAA to produce acetyloxyl (CH3C(O)O ) and acetylperoxyl (CH3C(O)OO ) radicals with little  OH radical formation, and Co(II)/Co(III) is cycled.	oh radical	122-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
32186188-3	2020	For the first time, this study determined the reaction rates of PAA with Co(II) (kPAA,Co(II) = 1.70x101 to 6.67x102 M-1 s-1) and Co(III) (kPAA,Co(III) = 3.91x100 to 4.57x102 M-1 s-1) ions over initial pH 3.0-8.2, and evaluated thirty different aromatic organic compounds for degradation by Co/PAA.	Peracetic Acid	64-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-79
32186188-3	2020	For the first time, this study determined the reaction rates of PAA with Co(II) (kPAA,Co(II) = 1.70x101 to 6.67x102 M-1 s-1) and Co(III) (kPAA,Co(III) = 3.91x100 to 4.57x102 M-1 s-1) ions over initial pH 3.0-8.2, and evaluated thirty different aromatic organic compounds for degradation by Co/PAA.	Peracetic Acid	64-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-92
32186188-3	2020	For the first time, this study determined the reaction rates of PAA with Co(II) (kPAA,Co(II) = 1.70x101 to 6.67x102 M-1 s-1) and Co(III) (kPAA,Co(III) = 3.91x100 to 4.57x102 M-1 s-1) ions over initial pH 3.0-8.2, and evaluated thirty different aromatic organic compounds for degradation by Co/PAA.	Cobalt	73-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-92
32186188-3	2020	For the first time, this study determined the reaction rates of PAA with Co(II) (kPAA,Co(II) = 1.70x101 to 6.67x102 M-1 s-1) and Co(III) (kPAA,Co(III) = 3.91x100 to 4.57x102 M-1 s-1) ions over initial pH 3.0-8.2, and evaluated thirty different aromatic organic compounds for degradation by Co/PAA.	Peracetic Acid	82-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-79
32236281-5	2020	The naproxen platinum(iv) complex could easily undergo reduction and liberate the platinum(ii) complex and naproxen as well as exert a multifunctional antitumor mechanism: (i) the liberated platinum(ii) fragment would cause serious DNA injury; (ii) naproxen would inhibit COX-2 and decrease tumor-associated inflammation; and (iii) the naproxen platinum(iv) complex exhibited remarkable MMP-9 inhibition in tumor tissues.	naproxen platinum	4-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	272-277
32236281-5	2020	The naproxen platinum(iv) complex could easily undergo reduction and liberate the platinum(ii) complex and naproxen as well as exert a multifunctional antitumor mechanism: (i) the liberated platinum(ii) fragment would cause serious DNA injury; (ii) naproxen would inhibit COX-2 and decrease tumor-associated inflammation; and (iii) the naproxen platinum(iv) complex exhibited remarkable MMP-9 inhibition in tumor tissues.	platinum(ii)	82-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	272-277
32236281-5	2020	The naproxen platinum(iv) complex could easily undergo reduction and liberate the platinum(ii) complex and naproxen as well as exert a multifunctional antitumor mechanism: (i) the liberated platinum(ii) fragment would cause serious DNA injury; (ii) naproxen would inhibit COX-2 and decrease tumor-associated inflammation; and (iii) the naproxen platinum(iv) complex exhibited remarkable MMP-9 inhibition in tumor tissues.	Naproxen	4-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	272-277
32236281-5	2020	The naproxen platinum(iv) complex could easily undergo reduction and liberate the platinum(ii) complex and naproxen as well as exert a multifunctional antitumor mechanism: (i) the liberated platinum(ii) fragment would cause serious DNA injury; (ii) naproxen would inhibit COX-2 and decrease tumor-associated inflammation; and (iii) the naproxen platinum(iv) complex exhibited remarkable MMP-9 inhibition in tumor tissues.	Platinum	13-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	272-277
32236281-5	2020	The naproxen platinum(iv) complex could easily undergo reduction and liberate the platinum(ii) complex and naproxen as well as exert a multifunctional antitumor mechanism: (i) the liberated platinum(ii) fragment would cause serious DNA injury; (ii) naproxen would inhibit COX-2 and decrease tumor-associated inflammation; and (iii) the naproxen platinum(iv) complex exhibited remarkable MMP-9 inhibition in tumor tissues.	Naproxen	107-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	272-277
32236281-5	2020	The naproxen platinum(iv) complex could easily undergo reduction and liberate the platinum(ii) complex and naproxen as well as exert a multifunctional antitumor mechanism: (i) the liberated platinum(ii) fragment would cause serious DNA injury; (ii) naproxen would inhibit COX-2 and decrease tumor-associated inflammation; and (iii) the naproxen platinum(iv) complex exhibited remarkable MMP-9 inhibition in tumor tissues.	Naproxen	107-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	272-277
32236281-5	2020	The naproxen platinum(iv) complex could easily undergo reduction and liberate the platinum(ii) complex and naproxen as well as exert a multifunctional antitumor mechanism: (i) the liberated platinum(ii) fragment would cause serious DNA injury; (ii) naproxen would inhibit COX-2 and decrease tumor-associated inflammation; and (iii) the naproxen platinum(iv) complex exhibited remarkable MMP-9 inhibition in tumor tissues.	Platinum	82-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	272-277
32239022-0	2020	Coordination polymers of a bis-isophthalate bridging ligand with single molecule magnet behaviour of the CoII analogue.	Polymers	13-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-109
32239022-0	2020	Coordination polymers of a bis-isophthalate bridging ligand with single molecule magnet behaviour of the CoII analogue.	bis-isophthalate	27-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-109
32239026-3	2020	Complex 2d was probably formed via a disproportionation reaction of the iPr[NCN]Co(ii) species with excess CoCl2 during the reaction.	cobaltous chloride	107-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-86
32239026-4	2020	Nevertheless, addition of CoCl2 to in situ formed 1d-THF at room temperature did not lead to 2d but gave a trinuclear Co(ii) complex {iPr[NCN]Co(mu-Cl)(mu-Br/Cl)}2Co (1d-CoCl2) in moderate yield.	cobaltous chloride	26-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-124
32239026-4	2020	Nevertheless, addition of CoCl2 to in situ formed 1d-THF at room temperature did not lead to 2d but gave a trinuclear Co(ii) complex {iPr[NCN]Co(mu-Cl)(mu-Br/Cl)}2Co (1d-CoCl2) in moderate yield.	1d-thf	50-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-124
32239026-4	2020	Nevertheless, addition of CoCl2 to in situ formed 1d-THF at room temperature did not lead to 2d but gave a trinuclear Co(ii) complex {iPr[NCN]Co(mu-Cl)(mu-Br/Cl)}2Co (1d-CoCl2) in moderate yield.	co(mu-cl)	142-151	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-124
32239026-4	2020	Nevertheless, addition of CoCl2 to in situ formed 1d-THF at room temperature did not lead to 2d but gave a trinuclear Co(ii) complex {iPr[NCN]Co(mu-Cl)(mu-Br/Cl)}2Co (1d-CoCl2) in moderate yield.	mu-br	152-157	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-124
33489855-6	2021	These results suggest that COX-2 expression is associated with 5-FU resistance.	Fluorouracil	63-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-32
33489855-8	2021	Treatment of cells with the COX-2 selective inhibitor celecoxib induced cell death of AGS FR cells in a time- and concentration-dependent manner.	Celecoxib	54-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
33489855-10	2021	This apoptotic induction was strongly supported by the expression profiles of apoptosis- and survival-associated proteins in response to celecoxib; pro-apoptotic cellular proteins increased while expressions of COX-2 and p-Akt were downregulated in a concentration-dependent manner.	Celecoxib	137-146	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	211-216
33489855-12	2021	Based on the data that downregulation of COX-2 was correlated with the concentrations of celecoxib, COX-2 may play a key role in celecoxib-induced cell death of AGS FR cells.	Celecoxib	89-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-46
33489855-12	2021	Based on the data that downregulation of COX-2 was correlated with the concentrations of celecoxib, COX-2 may play a key role in celecoxib-induced cell death of AGS FR cells.	Celecoxib	89-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-105
33489855-12	2021	Based on the data that downregulation of COX-2 was correlated with the concentrations of celecoxib, COX-2 may play a key role in celecoxib-induced cell death of AGS FR cells.	Celecoxib	129-138	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-46
33489855-12	2021	Based on the data that downregulation of COX-2 was correlated with the concentrations of celecoxib, COX-2 may play a key role in celecoxib-induced cell death of AGS FR cells.	Celecoxib	129-138	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-105
33489855-14	2021	In cells exposed to butaprost, expressions of COX-2 and p-Akt were increased in a concentration-dependent manner with concomitantly reduced PTEN levels.	butaprost	20-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
33489855-15	2021	Taken together, 5-FU-resistance in gastric cancer is correlated with COX-2 expression, and therefore the selective inhibition of COX-2 leads to suppression of cell proliferation of AGS FR cells.	Fluorouracil	16-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-74
33489855-15	2021	Taken together, 5-FU-resistance in gastric cancer is correlated with COX-2 expression, and therefore the selective inhibition of COX-2 leads to suppression of cell proliferation of AGS FR cells.	Fluorouracil	16-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-134
33489855-16	2021	Modulation of COX-2 expression and its catalytic activity may be a potential therapeutic strategy to overcome 5-FU-resistant gastric cancer.	Fluorouracil	110-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
32208383-6	2020	Importantly, the FDA-approved drug celecoxib, and its non-COX2-inhibiting analogue dimethyl-celecoxib, stimulated the PI3K/Akt-integrin alpha5beta1 axis and restored airway epithelial repair in cells from children with wheeze.	Celecoxib	35-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-62
32208383-6	2020	Importantly, the FDA-approved drug celecoxib, and its non-COX2-inhibiting analogue dimethyl-celecoxib, stimulated the PI3K/Akt-integrin alpha5beta1 axis and restored airway epithelial repair in cells from children with wheeze.	dimethyl-celecoxib	83-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-62
32155075-6	2020	A model antibody fragment crystallizable (Fc) region in solution with CoII-tannic acid complexes revealed that the solvent-exposed CoII can directly coordinate to the histidine-rich portion of the Fc region.	Histidine	167-176	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-74
32155075-6	2020	A model antibody fragment crystallizable (Fc) region in solution with CoII-tannic acid complexes revealed that the solvent-exposed CoII can directly coordinate to the histidine-rich portion of the Fc region.	Histidine	167-176	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-135
32328199-0	2020	Synergistic Effects of Curcumin and 5-Fluorouracil on the Hepatocellular Carcinoma In vivo and vitro through regulating the expression of COX-2 and NF-kappaB.	Curcumin	23-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	138-143
32328199-0	2020	Synergistic Effects of Curcumin and 5-Fluorouracil on the Hepatocellular Carcinoma In vivo and vitro through regulating the expression of COX-2 and NF-kappaB.	Fluorouracil	36-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	138-143
32317963-14	2020	At 100 muM, maximal inhibition of the two prostanoids was associated with the downregulation of COX-2 protein by 86%.	Prostaglandins	42-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-101
32328122-6	2020	Rb-ME attenuated MMP9 and COX-2 gene expression but enhanced SIRT1 and type-1 collagen in UVB-irradiated HaCaT cells.	rb-me	0-5	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-31
32317963-16	2020	In HUVEC, AF3485 at 100 muM caused a significant (P < 0.05) induction of COX-2 protein associated with enhanced PGI2 production.	n-[9-(2-hydroxyethyl)-9h-carbazol-3-yl]-2-(trifluoromethyl)benzamide	10-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-78
32317963-18	2020	Conclusions: The inhibitor of human mPGES-1 AF3485 is a novel antiinflammatory compound which can also modulate COX-2 induction by inflammatory stimuli.	n-[9-(2-hydroxyethyl)-9h-carbazol-3-yl]-2-(trifluoromethyl)benzamide	44-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-117
32317963-19	2020	The compound also induces endothelial COX-2-dependent PGI2 production via PPARgamma activation, both in vitro and in vivo, which might translate into a protective effect for the cardiovascular system.	Epoprostenol	54-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-43
32127262-5	2020	Benzimidazole-thiazole hybrid 15b was the most potent dual COX-2 (IC50 = 0.045 microM, SI = 294) inhibitor approximate to celecoxib (COX-2; IC50 = 0.045 microM, SI = 327), with double inhibitory activity versus 15-LOX enzyme (IC50 = 1.67 microM) relative to quercetin (IC50 = 3.34 microM).	benzimidazole-thiazole	0-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	133-138
32127262-3	2020	Benzimidazole-thiazole hybrids linked to acetyl moiety 13, phenyl thiosemicarbazone 14, 1,3-thiazolines 15a-c and 4-thiazolidinone 16 exhibited significant COX-2 inhibition (IC50 = 0.045-0.075 microM) with significant COX-2 selectivity indices (SI = 142-294).	benzimidazole-thiazole	0-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	156-161
32127262-3	2020	Benzimidazole-thiazole hybrids linked to acetyl moiety 13, phenyl thiosemicarbazone 14, 1,3-thiazolines 15a-c and 4-thiazolidinone 16 exhibited significant COX-2 inhibition (IC50 = 0.045-0.075 microM) with significant COX-2 selectivity indices (SI = 142-294).	benzimidazole-thiazole	0-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	218-223
32127262-3	2020	Benzimidazole-thiazole hybrids linked to acetyl moiety 13, phenyl thiosemicarbazone 14, 1,3-thiazolines 15a-c and 4-thiazolidinone 16 exhibited significant COX-2 inhibition (IC50 = 0.045-0.075 microM) with significant COX-2 selectivity indices (SI = 142-294).	Cysteine	41-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	156-161
32086052-0	2020	Further insight into the dual COX-2 and 15-LOX anti-inflammatory activity of 1,3,4-thiadiazole-thiazolidinone hybrids: The contribution of the substituents at 5th positions is size dependent.	1,3,4-thiadiazole-thiazolidinone	77-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-35
32127262-5	2020	Benzimidazole-thiazole hybrid 15b was the most potent dual COX-2 (IC50 = 0.045 microM, SI = 294) inhibitor approximate to celecoxib (COX-2; IC50 = 0.045 microM, SI = 327), with double inhibitory activity versus 15-LOX enzyme (IC50 = 1.67 microM) relative to quercetin (IC50 = 3.34 microM).	Celecoxib	122-131	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-64
32088417-1	2020	Selective COX-2 inhibitor celecoxib was found directly inhibiting the growth of tested phytopathogenic fungi with the inhibitory rate ranging from 30 to 40% at 100 microg/ml.	Celecoxib	26-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
32337281-7	2020	The expression of COX-2 was upregulated by p38MAPK, which could be phosphorylated by Ang II, while there was an increasing tendency of p38MAPK phosphorylation after TNF-alpha stimulation.	Angiotensin II	85-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-23
31916080-4	2020	Among NSAIDs, diclofenac appeared to be associated with a relatively higher risk of MI, similar to that of rofecoxib, compatible with the drug"s high COX-2 inhibitory potency.	Diclofenac	14-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	150-155
32127262-3	2020	Benzimidazole-thiazole hybrids linked to acetyl moiety 13, phenyl thiosemicarbazone 14, 1,3-thiazolines 15a-c and 4-thiazolidinone 16 exhibited significant COX-2 inhibition (IC50 = 0.045-0.075 microM) with significant COX-2 selectivity indices (SI = 142-294).	Cysteine	41-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	218-223
32127262-3	2020	Benzimidazole-thiazole hybrids linked to acetyl moiety 13, phenyl thiosemicarbazone 14, 1,3-thiazolines 15a-c and 4-thiazolidinone 16 exhibited significant COX-2 inhibition (IC50 = 0.045-0.075 microM) with significant COX-2 selectivity indices (SI = 142-294).	phenyl thiosemicarbazone	59-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	156-161
32127262-3	2020	Benzimidazole-thiazole hybrids linked to acetyl moiety 13, phenyl thiosemicarbazone 14, 1,3-thiazolines 15a-c and 4-thiazolidinone 16 exhibited significant COX-2 inhibition (IC50 = 0.045-0.075 microM) with significant COX-2 selectivity indices (SI = 142-294).	phenyl thiosemicarbazone	59-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	218-223
32127262-3	2020	Benzimidazole-thiazole hybrids linked to acetyl moiety 13, phenyl thiosemicarbazone 14, 1,3-thiazolines 15a-c and 4-thiazolidinone 16 exhibited significant COX-2 inhibition (IC50 = 0.045-0.075 microM) with significant COX-2 selectivity indices (SI = 142-294).	1,3-thiazolines	88-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	156-161
32127262-3	2020	Benzimidazole-thiazole hybrids linked to acetyl moiety 13, phenyl thiosemicarbazone 14, 1,3-thiazolines 15a-c and 4-thiazolidinone 16 exhibited significant COX-2 inhibition (IC50 = 0.045-0.075 microM) with significant COX-2 selectivity indices (SI = 142-294).	1,3-thiazolines	88-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	218-223
32127262-3	2020	Benzimidazole-thiazole hybrids linked to acetyl moiety 13, phenyl thiosemicarbazone 14, 1,3-thiazolines 15a-c and 4-thiazolidinone 16 exhibited significant COX-2 inhibition (IC50 = 0.045-0.075 microM) with significant COX-2 selectivity indices (SI = 142-294).	4-thiazolidinone	114-130	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	156-161
32127262-3	2020	Benzimidazole-thiazole hybrids linked to acetyl moiety 13, phenyl thiosemicarbazone 14, 1,3-thiazolines 15a-c and 4-thiazolidinone 16 exhibited significant COX-2 inhibition (IC50 = 0.045-0.075 microM) with significant COX-2 selectivity indices (SI = 142-294).	4-thiazolidinone	114-130	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	218-223
32127262-5	2020	Benzimidazole-thiazole hybrid 15b was the most potent dual COX-2 (IC50 = 0.045 microM, SI = 294) inhibitor approximate to celecoxib (COX-2; IC50 = 0.045 microM, SI = 327), with double inhibitory activity versus 15-LOX enzyme (IC50 = 1.67 microM) relative to quercetin (IC50 = 3.34 microM).	benzimidazole-thiazole	0-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-64
32061902-8	2020	Anthocyanin supplementation also down-regulated the expression of NF-kappaB dependent genes including TNF-alpha (-28% and -15%), IL-6 (-16.1% and-13.6%), IL-1A (-21.5% and-12.9%), PCAM-1 (-15% and-17.5%), and COX-2(-26% and-27%) in both MetS and Control group respectively (P-value &lt; 0.05).	Anthocyanins	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	209-214
32127262-5	2020	Benzimidazole-thiazole hybrid 15b was the most potent dual COX-2 (IC50 = 0.045 microM, SI = 294) inhibitor approximate to celecoxib (COX-2; IC50 = 0.045 microM, SI = 327), with double inhibitory activity versus 15-LOX enzyme (IC50 = 1.67 microM) relative to quercetin (IC50 = 3.34 microM).	Celecoxib	122-131	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	133-138
32004548-6	2020	Our results demonstrated that both in in vitro neuroinflammatory model and in vivo model of SCI the treatment with SP significantly reduced NF-kappaB nuclear translocation and IkappaBalpha degradation, as well as decreases COX-2 and iNOS expressions evaluated by Western blot analysis.	sodium propionate	115-117	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	223-228
31776889-4	2020	Using human THP-1 macrophage, we first confirmed that incorporation of PNA into cellular phospholipids suppressed the production of interleukin-6 (IL-6) (by 46%), tumor necrosis factor-alpha (TNF-alpha) (by 18%), and prostaglandin E2 (PGE2) (by 87%), and the expression of type-2 cyclooxygenase (COX-2) (by 27%).	5,9,12-octadecatrienoic acid	71-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	296-301
32221501-4	2020	Now, a Mg(II)Co(II) catalyst is reported that exhibits significantly better activity (turnover frequency > 12,000 h-1) and high selectivity (>99% CO2 utilization and polycarbonate selectivity) for carbon dioxide and cyclohexene oxide copolymerization.	Carbon Dioxide	146-149	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-19
32221501-4	2020	Now, a Mg(II)Co(II) catalyst is reported that exhibits significantly better activity (turnover frequency > 12,000 h-1) and high selectivity (>99% CO2 utilization and polycarbonate selectivity) for carbon dioxide and cyclohexene oxide copolymerization.	Carbon Dioxide	197-211	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-19
32221501-4	2020	Now, a Mg(II)Co(II) catalyst is reported that exhibits significantly better activity (turnover frequency > 12,000 h-1) and high selectivity (>99% CO2 utilization and polycarbonate selectivity) for carbon dioxide and cyclohexene oxide copolymerization.	cyclohexene oxide	216-233	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-19
32221501-6	2020	Kinetic data also reveal that synergy arises from differentiated roles for the metals in the mechanism: epoxide coordination occurs at Mg(II), with reduced transition state entropy, while the Co(II) centre accelerates carbonate attack by lowering the transition state enthalpy.	Epoxy Compounds	104-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	192-198
32221501-6	2020	Kinetic data also reveal that synergy arises from differentiated roles for the metals in the mechanism: epoxide coordination occurs at Mg(II), with reduced transition state entropy, while the Co(II) centre accelerates carbonate attack by lowering the transition state enthalpy.	Carbonates	218-227	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	192-198
32018066-0	2020	Andrographolide potentiates PD-1 blockade immunotherapy by inhibiting COX2-mediated PGE2 release.	andrographolide	0-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-74
32018066-0	2020	Andrographolide potentiates PD-1 blockade immunotherapy by inhibiting COX2-mediated PGE2 release.	Dinoprostone	84-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-74
31726219-2	2020	NSAIDs and their well-established action based on inhibiting the COX-1 and COX-2 enzyme leads to blockage of prostaglandin pathway.	Prostaglandins	109-122	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
32214022-5	2020	Our results indicate that even low concentrations of Pb cause an increase in production of inflammatory interleukins (IL-1beta and IL-6), increases expression of COX-1 and COX-2, and increases thromboxane B2 and prostaglandin E2 concentration in macrophages.	Lead	53-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	172-177
31806553-0	2020	Ultrasonic-assisted synthesis of the nanostructures of a Co(II) metal organic framework as a highly sensitive fluorescence probe of phenol derivatives.	Phenols	132-138	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-63
32061935-2	2020	The conserved COX2 subunit contains the CuA site, a binuclear copper center.	Copper	40-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-18
32061935-2	2020	The conserved COX2 subunit contains the CuA site, a binuclear copper center.	Copper	62-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-18
32213831-0	2020	Analysis of the Activity and Expression of Cyclooxygenases COX1 and COX2 in THP-1 Monocytes and Macrophages Cultured with BiodentineTM Silicate Cement.	biodentinetm silicate	122-143	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-72
32223750-13	2020	Co-culturing of melatonin with LPS resulted in the reduction of COX-2 and IL-1 beta expression in primary pulpal fibroblasts, indicating that melatonin may play an antagonistic role to LPS infection in pulpal fibroblasts.	Melatonin	16-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-69
32223750-15	2020	Melatonin exerted antagonistic activity against LPS-mediated COX-2 and IL-1 beta induction in pulpal fibroblasts, suggesting its therapeutic potential for pulpal inflammation and a possible role of pulpal melatonin in an immunomodulation via functional melatonin receptors expressed in dental pulp.	Melatonin	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-66
32256563-2	2020	Inositol and associated molecules display inhibitory properties against 5-alpha reductase, COX-2, and lipase enzymes in addition to their antimicrobial and anti-inflammatory properties.	Inositol	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-96
32213831-4	2020	The aim of the study was to investigate whether BiodentineTM, used in the regeneration of the pulp-dentine complex, may affect the expression of the enzymes cyclooxygenase 1 (COX1) and cyclooxygenase 2 (COX2) in THP-1 monocytes/macrophages and the amount of prostanoids synthesized by these enzymes-precursors of biologically active prostanoids such as prostaglandin E2 (PGE2) and thromboxane (TXB2) which are mediators of inflammation.	Prostaglandins	258-269	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	203-207
32213831-4	2020	The aim of the study was to investigate whether BiodentineTM, used in the regeneration of the pulp-dentine complex, may affect the expression of the enzymes cyclooxygenase 1 (COX1) and cyclooxygenase 2 (COX2) in THP-1 monocytes/macrophages and the amount of prostanoids synthesized by these enzymes-precursors of biologically active prostanoids such as prostaglandin E2 (PGE2) and thromboxane (TXB2) which are mediators of inflammation.	Prostaglandins	333-344	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	203-207
32213831-4	2020	The aim of the study was to investigate whether BiodentineTM, used in the regeneration of the pulp-dentine complex, may affect the expression of the enzymes cyclooxygenase 1 (COX1) and cyclooxygenase 2 (COX2) in THP-1 monocytes/macrophages and the amount of prostanoids synthesized by these enzymes-precursors of biologically active prostanoids such as prostaglandin E2 (PGE2) and thromboxane (TXB2) which are mediators of inflammation.	Dinoprostone	353-369	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	203-207
32118423-3	2020	The reaction employs commercially available Co(II) catalyst in the presence of Mn(III) cooxidant and oxygen as a terminal oxidant and proceeds with full preservation of original stereochemistry.	manganese(III) acetate dihydrate	79-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-50
32213831-4	2020	The aim of the study was to investigate whether BiodentineTM, used in the regeneration of the pulp-dentine complex, may affect the expression of the enzymes cyclooxygenase 1 (COX1) and cyclooxygenase 2 (COX2) in THP-1 monocytes/macrophages and the amount of prostanoids synthesized by these enzymes-precursors of biologically active prostanoids such as prostaglandin E2 (PGE2) and thromboxane (TXB2) which are mediators of inflammation.	Dinoprostone	371-375	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	203-207
32213831-4	2020	The aim of the study was to investigate whether BiodentineTM, used in the regeneration of the pulp-dentine complex, may affect the expression of the enzymes cyclooxygenase 1 (COX1) and cyclooxygenase 2 (COX2) in THP-1 monocytes/macrophages and the amount of prostanoids synthesized by these enzymes-precursors of biologically active prostanoids such as prostaglandin E2 (PGE2) and thromboxane (TXB2) which are mediators of inflammation.	Thromboxanes	381-392	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	203-207
32213831-4	2020	The aim of the study was to investigate whether BiodentineTM, used in the regeneration of the pulp-dentine complex, may affect the expression of the enzymes cyclooxygenase 1 (COX1) and cyclooxygenase 2 (COX2) in THP-1 monocytes/macrophages and the amount of prostanoids synthesized by these enzymes-precursors of biologically active prostanoids such as prostaglandin E2 (PGE2) and thromboxane (TXB2) which are mediators of inflammation.	Thromboxane B2	394-398	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	203-207
31691474-6	2020	The experimental studies and DFT calculations reveal that the high performance of the Co@FLG is mainly attributed to its great O2 absorptivity endowed by the abundant Co-Nx and pyridinic-N in the FLG shell and the strong electron-donating ability from the Co ND core to the FLG shell to elevate the eg-orbital energy of Co(II) and lower the activation energy for breaking the O=O/O-O bonds.	Superoxides	127-129	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	320-326
31691474-6	2020	The experimental studies and DFT calculations reveal that the high performance of the Co@FLG is mainly attributed to its great O2 absorptivity endowed by the abundant Co-Nx and pyridinic-N in the FLG shell and the strong electron-donating ability from the Co ND core to the FLG shell to elevate the eg-orbital energy of Co(II) and lower the activation energy for breaking the O=O/O-O bonds.	Nitrogen	177-188	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	320-326
31691474-6	2020	The experimental studies and DFT calculations reveal that the high performance of the Co@FLG is mainly attributed to its great O2 absorptivity endowed by the abundant Co-Nx and pyridinic-N in the FLG shell and the strong electron-donating ability from the Co ND core to the FLG shell to elevate the eg-orbital energy of Co(II) and lower the activation energy for breaking the O=O/O-O bonds.	Superoxides	380-383	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	320-326
32118423-3	2020	The reaction employs commercially available Co(II) catalyst in the presence of Mn(III) cooxidant and oxygen as a terminal oxidant and proceeds with full preservation of original stereochemistry.	Oxygen	101-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-50
32157173-0	2020	Author Correction: The roles of p38 MAPK   COX2 and NF-kappaB   COX2 signal pathways in age-related testosterone reduction.	Testosterone	100-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-47
32133844-4	2020	The model is validated through a comparison of the predicted electrochemical potentials with the irreversible cyclic voltammogram of [Co2LAc]+, which shows redox-coupled spin-crossover (RCSCO) behavior for the CoII/III transitions.	co2lac	134-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	210-218
32218705-6	2020	Aspirin inhibited COX-2 and iNOS without changes in COX-1 expression, increasing anti-oxidant protein (Cu/Zn-SOD and Mn-SOD) expression in presence or absence of Abeta1-42.	Aspirin	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-23
32157173-0	2020	Author Correction: The roles of p38 MAPK   COX2 and NF-kappaB   COX2 signal pathways in age-related testosterone reduction.	Testosterone	100-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-68
32044026-6	2020	Mg-G1 displayed inhibitory activity against human intestinal maltase and COX-2.	mg-g1	0-5	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-78
32196098-6	2020	Results: Treatment with noncytotoxic concentrations of GS resulted in the dose-dependent inhibition of IL-1beta-induced inflammatory cytokines, including IL-6, IL-8, MCP-1, and COX-2, at both mRNA and protein levels.	pregna-4,17-diene-3,16-dione	55-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	177-182
32008081-0	2020	Development of a liquid-nitrogen-induced homogeneous liquid-liquid microextraction of Co(II) and Ni(II) from water and fruit juice samples followed by atomic absorption spectrometry detection.	Nitrogen	24-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-103
32008081-1	2020	In this study, a simple and rapid sample preparation method named liquid-nitrogen-induced homogeneous liquid-liquid microextraction has been developed for the extraction and pre-concentration of Co(II) and Ni(II) ions before their analysis by flame atomic absorption spectrometry.	Nitrogen	73-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	195-201
32181121-0	2020	Structural modification of aspirin to design a new potential cyclooxygenase (COX-2) inhibitors.	Aspirin	27-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-82
31302749-6	2020	Increased proliferation and migration after 17beta-HSD12 knockdown were partly mediated by metabolism of arachidonic acid towards COX2 and CYP1B1-derived eicosanoids.	Arachidonic Acid	105-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	130-134
30898030-7	2020	Here, we report molecular dynamics data from 16 flavonoid-COX-2 complexes performed for 50 nanoseconds each that demonstrates key structural and dynamic aspects of flavonoid-based COX inhibition in light of observed experimental facts.	Flavonoids	48-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
31982653-3	2020	In the present study, a hybridization strategy was adopted to combine the binding features of the non-selective COX inhibitor "sulindac" and the selective COX-2 inhibitor "celecoxib" which show 5-LOX inhibitory activity with that of licofelone and a celecoxib pyridone analogue which show dual COX-2/5-LOX inhibitory activity to design new series of pyrazole sulfonamide derivatives which, by design, should possess dual COX-2/5-LOX inhibitory activity.	pyrazole sulfonamide	350-370	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	155-160
31982653-3	2020	In the present study, a hybridization strategy was adopted to combine the binding features of the non-selective COX inhibitor "sulindac" and the selective COX-2 inhibitor "celecoxib" which show 5-LOX inhibitory activity with that of licofelone and a celecoxib pyridone analogue which show dual COX-2/5-LOX inhibitory activity to design new series of pyrazole sulfonamide derivatives which, by design, should possess dual COX-2/5-LOX inhibitory activity.	Sulindac	127-135	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	294-299
31982653-3	2020	In the present study, a hybridization strategy was adopted to combine the binding features of the non-selective COX inhibitor "sulindac" and the selective COX-2 inhibitor "celecoxib" which show 5-LOX inhibitory activity with that of licofelone and a celecoxib pyridone analogue which show dual COX-2/5-LOX inhibitory activity to design new series of pyrazole sulfonamide derivatives which, by design, should possess dual COX-2/5-LOX inhibitory activity.	Sulindac	127-135	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	294-299
31982653-3	2020	In the present study, a hybridization strategy was adopted to combine the binding features of the non-selective COX inhibitor "sulindac" and the selective COX-2 inhibitor "celecoxib" which show 5-LOX inhibitory activity with that of licofelone and a celecoxib pyridone analogue which show dual COX-2/5-LOX inhibitory activity to design new series of pyrazole sulfonamide derivatives which, by design, should possess dual COX-2/5-LOX inhibitory activity.	Celecoxib	172-181	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	155-160
31982653-3	2020	In the present study, a hybridization strategy was adopted to combine the binding features of the non-selective COX inhibitor "sulindac" and the selective COX-2 inhibitor "celecoxib" which show 5-LOX inhibitory activity with that of licofelone and a celecoxib pyridone analogue which show dual COX-2/5-LOX inhibitory activity to design new series of pyrazole sulfonamide derivatives which, by design, should possess dual COX-2/5-LOX inhibitory activity.	Celecoxib	172-181	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	294-299
31982653-3	2020	In the present study, a hybridization strategy was adopted to combine the binding features of the non-selective COX inhibitor "sulindac" and the selective COX-2 inhibitor "celecoxib" which show 5-LOX inhibitory activity with that of licofelone and a celecoxib pyridone analogue which show dual COX-2/5-LOX inhibitory activity to design new series of pyrazole sulfonamide derivatives which, by design, should possess dual COX-2/5-LOX inhibitory activity.	Celecoxib	172-181	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	294-299
31982653-3	2020	In the present study, a hybridization strategy was adopted to combine the binding features of the non-selective COX inhibitor "sulindac" and the selective COX-2 inhibitor "celecoxib" which show 5-LOX inhibitory activity with that of licofelone and a celecoxib pyridone analogue which show dual COX-2/5-LOX inhibitory activity to design new series of pyrazole sulfonamide derivatives which, by design, should possess dual COX-2/5-LOX inhibitory activity.	licofelone	233-243	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	155-160
31982653-3	2020	In the present study, a hybridization strategy was adopted to combine the binding features of the non-selective COX inhibitor "sulindac" and the selective COX-2 inhibitor "celecoxib" which show 5-LOX inhibitory activity with that of licofelone and a celecoxib pyridone analogue which show dual COX-2/5-LOX inhibitory activity to design new series of pyrazole sulfonamide derivatives which, by design, should possess dual COX-2/5-LOX inhibitory activity.	celecoxib pyridone	250-268	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	155-160
30898030-7	2020	Here, we report molecular dynamics data from 16 flavonoid-COX-2 complexes performed for 50 nanoseconds each that demonstrates key structural and dynamic aspects of flavonoid-based COX inhibition in light of observed experimental facts.	Flavonoids	164-173	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
30955453-3	2020	Molecular docking study of the CL-SA was carried out to clarify the probable binding modes between the title compound and DNA and COX-2 and TOPII enzymes.	cl-sa	31-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	130-135
32048665-1	2020	The first examples of Co(ii) mesoionic carbene complexes (CoX2DippMIC2; X = Cl-, Br-, I-) demonstrate a new electronic perturbation on tetrahedral Co(ii) complexes.	carbene	39-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-28
32048665-1	2020	The first examples of Co(ii) mesoionic carbene complexes (CoX2DippMIC2; X = Cl-, Br-, I-) demonstrate a new electronic perturbation on tetrahedral Co(ii) complexes.	carbene	39-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-153
32048665-1	2020	The first examples of Co(ii) mesoionic carbene complexes (CoX2DippMIC2; X = Cl-, Br-, I-) demonstrate a new electronic perturbation on tetrahedral Co(ii) complexes.	3-bromoacetoxyandrostan-17-one	81-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-28
32048665-1	2020	The first examples of Co(ii) mesoionic carbene complexes (CoX2DippMIC2; X = Cl-, Br-, I-) demonstrate a new electronic perturbation on tetrahedral Co(ii) complexes.	3-bromoacetoxyandrostan-17-one	81-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-153
32094439-0	2020	A representative metalloprotease induces PGE2 synthesis in fibroblast-like synoviocytes via the NF-kappaB/COX-2 pathway with amplification by IL-1beta and the EP4 receptor.	Dinoprostone	41-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-111
32106569-1	2020	In the present work, tenoxicam (H2Ten) reacted with Mn(II), Co(II), Ni(II), Cu(II) and Zn (II) ions in the presence of 1.10-phenthroline (Phen), forming new mixed ligand metal complexes.	phenthroline	124-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-66
32106569-1	2020	In the present work, tenoxicam (H2Ten) reacted with Mn(II), Co(II), Ni(II), Cu(II) and Zn (II) ions in the presence of 1.10-phenthroline (Phen), forming new mixed ligand metal complexes.	tenoxicam	21-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-66
32106569-1	2020	In the present work, tenoxicam (H2Ten) reacted with Mn(II), Co(II), Ni(II), Cu(II) and Zn (II) ions in the presence of 1.10-phenthroline (Phen), forming new mixed ligand metal complexes.	h2ten	32-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-66
32094439-2	2020	This study showed that the snake venom metalloprotease (SVMP) BaP1 activates FLSs to produce PGE2 by a mechanism dependent on COX-2, mPGES-1 and iPLA2s.	Dinoprostone	93-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-131
32094439-7	2020	Engagement of this receptor by PGE2 triggers a positive feedback loop for its production by up-regulating expression of key components of the PGE2 biosynthetic cascade (COX-2, mPGES-1 and the EP4 receptor), thus contributing to amplification of BaP1-induced effects in FLSs.	Dinoprostone	31-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	169-174
32094439-7	2020	Engagement of this receptor by PGE2 triggers a positive feedback loop for its production by up-regulating expression of key components of the PGE2 biosynthetic cascade (COX-2, mPGES-1 and the EP4 receptor), thus contributing to amplification of BaP1-induced effects in FLSs.	Dinoprostone	142-146	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	169-174
32011125-1	2020	The synthesis, structural characterization, and magnetic behavior of a new family of binuclear CoII-LnIII complexes of formula [LnIIICoIIL2(NO3)3] H2O (Ln = La, 1; Gd, 2; Tb, 3; Dy, 4; Ho, 5; HL = 3-methoxy-N-(2-(methylsulfanyl)phenyl)salicylaldimine) have been reported.	N,N'-(3,4-diaminobenzophenon)-3,5-Bu(t)(2)-salicylaldimine	197-250	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-99
31862467-8	2020	Also BCP improved the stress-related changes in the hippocampal expression of COX-2, BDNF, and CB2 receptor expression.	caryophyllene	5-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-83
32054883-0	2020	Downregulation of peripheral PTGS2/COX-2 in response to valproate treatment in patients with epilepsy.	Valproic Acid	56-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40
32075199-2	2020	Two new mononuclear complexes of the type [MII(L)2](ClO4)2 (with M = FeII (C1) and CoII (C2)) have been synthesized, containing the new ligand (L).	2,3-dimethoxy-8,9-methylenedioxy-11H-indeno(1,2-c)isoquinoline	42-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-87
32009382-1	2020	Three new molybdate-tellurites, K2M9(TeO3)4(MoO4)4(OH)4 (M = NiII and CoII) and (NH4)2Cu9II(TeO3)4(MoO4)4(OH)4, have been successfully synthesized by conventional hydrothermal method.	antibiotic K 4	32-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-74
32011125-0	2020	Unusually Distorted Pseudo-Octahedral Coordination Environment Around CoII from Thioether Schiff Base Ligands in Dinuclear [CoLn] (Ln = La, Gd, Tb, Dy, Ho) Complexes: Synthesis, Structure, and Understanding of Magnetic Behavior.	Sulfides	80-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-74
32011125-0	2020	Unusually Distorted Pseudo-Octahedral Coordination Environment Around CoII from Thioether Schiff Base Ligands in Dinuclear [CoLn] (Ln = La, Gd, Tb, Dy, Ho) Complexes: Synthesis, Structure, and Understanding of Magnetic Behavior.	bis(citric acid)lanthanum(III)	124-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-74
32011125-0	2020	Unusually Distorted Pseudo-Octahedral Coordination Environment Around CoII from Thioether Schiff Base Ligands in Dinuclear [CoLn] (Ln = La, Gd, Tb, Dy, Ho) Complexes: Synthesis, Structure, and Understanding of Magnetic Behavior.	Gadolinium	140-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-74
32011125-0	2020	Unusually Distorted Pseudo-Octahedral Coordination Environment Around CoII from Thioether Schiff Base Ligands in Dinuclear [CoLn] (Ln = La, Gd, Tb, Dy, Ho) Complexes: Synthesis, Structure, and Understanding of Magnetic Behavior.	Terbium	144-146	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-74
32011125-0	2020	Unusually Distorted Pseudo-Octahedral Coordination Environment Around CoII from Thioether Schiff Base Ligands in Dinuclear [CoLn] (Ln = La, Gd, Tb, Dy, Ho) Complexes: Synthesis, Structure, and Understanding of Magnetic Behavior.	Holmium	152-154	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-74
32011125-1	2020	The synthesis, structural characterization, and magnetic behavior of a new family of binuclear CoII-LnIII complexes of formula [LnIIICoIIL2(NO3)3] H2O (Ln = La, 1; Gd, 2; Tb, 3; Dy, 4; Ho, 5; HL = 3-methoxy-N-(2-(methylsulfanyl)phenyl)salicylaldimine) have been reported.	adhesin, Pseudomonas	127-150	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-99
32011125-1	2020	The synthesis, structural characterization, and magnetic behavior of a new family of binuclear CoII-LnIII complexes of formula [LnIIICoIIL2(NO3)3] H2O (Ln = La, 1; Gd, 2; Tb, 3; Dy, 4; Ho, 5; HL = 3-methoxy-N-(2-(methylsulfanyl)phenyl)salicylaldimine) have been reported.	Gadolinium	164-166	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-99
32011125-1	2020	The synthesis, structural characterization, and magnetic behavior of a new family of binuclear CoII-LnIII complexes of formula [LnIIICoIIL2(NO3)3] H2O (Ln = La, 1; Gd, 2; Tb, 3; Dy, 4; Ho, 5; HL = 3-methoxy-N-(2-(methylsulfanyl)phenyl)salicylaldimine) have been reported.	Terbium	171-173	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-99
32011125-1	2020	The synthesis, structural characterization, and magnetic behavior of a new family of binuclear CoII-LnIII complexes of formula [LnIIICoIIL2(NO3)3] H2O (Ln = La, 1; Gd, 2; Tb, 3; Dy, 4; Ho, 5; HL = 3-methoxy-N-(2-(methylsulfanyl)phenyl)salicylaldimine) have been reported.	Holmium	185-187	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-99
32054883-5	2020	PTGS2/COX-2 mRNA profiles in the two groups corresponded to their plasma profiles of the COX-2 product, prostaglandin E2 (PGE2).	Dinoprostone	104-120	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	6-11
32054883-5	2020	PTGS2/COX-2 mRNA profiles in the two groups corresponded to their plasma profiles of the COX-2 product, prostaglandin E2 (PGE2).	Dinoprostone	122-126	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	6-11
32054883-7	2020	Investigation of the effect of VA upon the brain endothelial cells (hCMEC/D3) in hyperexcitatory conditions confirmed suppression of COX-2-dependent P-gp upregulation by VA.	Valproic Acid	170-172	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	133-138
31747078-2	2020	In this work, we precisely anchor catalytic active cobalt porphyrin [TCPP(Co) = (5,10,15,20)-tetrakis(4-carboxyphenyl)porphyrin-Co(II)] onto the water-stable 2-D MOF nanosheets (Zr-BTB) to obtain ultra-thin 2-D MOF nanosheets [TCPP(Co)/Zr-BTB] with accessible catalytic sites for CO2 reduction reaction.	Cobalt	51-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	128-134
32046692-0	2020	Lirioresinol B dimethyl ether inhibits NF-kappaB and COX-2 and activates IkappaBalpha expression in CCl4-induced hepatic fibrosis.	dimethyl ether	0-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-58
32046692-9	2020	Western blot results show that LBDE down-regulated nuclear factor kappa B (NFkappaB) and cyclooxygenase (COX-2) by preventing the phosphorylation of I kappa B alpha (IkappaBalpha) in CCl4 treated group.	dimethyl ether	31-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-110
32046692-12	2020	CONCLUSIONS: These preliminary results show that LBDE has the potential to inhibit CCl4-induced liver cell dysplasia and prevents cancer development by regulating NFkappaB/COX-2 activation.	dimethyl ether	49-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	172-177
31747078-2	2020	In this work, we precisely anchor catalytic active cobalt porphyrin [TCPP(Co) = (5,10,15,20)-tetrakis(4-carboxyphenyl)porphyrin-Co(II)] onto the water-stable 2-D MOF nanosheets (Zr-BTB) to obtain ultra-thin 2-D MOF nanosheets [TCPP(Co)/Zr-BTB] with accessible catalytic sites for CO2 reduction reaction.	Porphyrins	58-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	128-134
31747078-2	2020	In this work, we precisely anchor catalytic active cobalt porphyrin [TCPP(Co) = (5,10,15,20)-tetrakis(4-carboxyphenyl)porphyrin-Co(II)] onto the water-stable 2-D MOF nanosheets (Zr-BTB) to obtain ultra-thin 2-D MOF nanosheets [TCPP(Co)/Zr-BTB] with accessible catalytic sites for CO2 reduction reaction.	tetracarboxyphenylporphine	69-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	128-134
31747078-2	2020	In this work, we precisely anchor catalytic active cobalt porphyrin [TCPP(Co) = (5,10,15,20)-tetrakis(4-carboxyphenyl)porphyrin-Co(II)] onto the water-stable 2-D MOF nanosheets (Zr-BTB) to obtain ultra-thin 2-D MOF nanosheets [TCPP(Co)/Zr-BTB] with accessible catalytic sites for CO2 reduction reaction.	12-(4'-azido-2'-nitrophenoxy)dodecanoyl-coenzyme A	74-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	128-134
31747078-2	2020	In this work, we precisely anchor catalytic active cobalt porphyrin [TCPP(Co) = (5,10,15,20)-tetrakis(4-carboxyphenyl)porphyrin-Co(II)] onto the water-stable 2-D MOF nanosheets (Zr-BTB) to obtain ultra-thin 2-D MOF nanosheets [TCPP(Co)/Zr-BTB] with accessible catalytic sites for CO2 reduction reaction.	5,10,15,20-tetrakis(4-carboxyphenyl)porphyrin cobalt	69-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	128-134
31498191-14	2020	Conversely, lidocaine exhibited repression of IL-6 and IL-8 release over all time points, and early downregulation of COX2 and cell adhesion molecules, which was followed by a late overshooting reaction.	Lidocaine	12-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-122
31944097-3	2020	Topologically, the 4-c Na(I) ion directs in situ assembly of 4-c SDCA linker and 6-c Co(II) ion, resulting in the formation of 4,4,6-c net with a topology named as smm3.	Sodium	23-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-91
31944097-3	2020	Topologically, the 4-c Na(I) ion directs in situ assembly of 4-c SDCA linker and 6-c Co(II) ion, resulting in the formation of 4,4,6-c net with a topology named as smm3.	Cyclosporine	61-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-91
31944097-3	2020	Topologically, the 4-c Na(I) ion directs in situ assembly of 4-c SDCA linker and 6-c Co(II) ion, resulting in the formation of 4,4,6-c net with a topology named as smm3.	Cyclosporine	127-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-91
31944679-0	2020	Metal Ion (NiII vs CoII)-Mediated Unusual Amine-Imine Interconversion in Conjugated Amine-ene-imine Ligand: Synthesis, Structure, and Characterization.	Imines	42-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-23
31944679-0	2020	Metal Ion (NiII vs CoII)-Mediated Unusual Amine-Imine Interconversion in Conjugated Amine-ene-imine Ligand: Synthesis, Structure, and Characterization.	Imines	84-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-23
31944679-5	2020	In contrast, Co(II) was silent to such amine-imine interconversion reactions under both HL1 and HL2 ligand environment.	Imines	39-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-19
32099405-8	2020	Foretinib treatment also significantly reduced phosphor-c-MET, phosphor-AKT, beta-catenin, and COX-2 protein expression in MKN45 and SNU620 cells.	GSK 1363089	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-100
31910337-4	2020	In particular, Mn(II), Co(II), Ni(II), and Cu(II) were reported for the first time to form such large and discrete structures with (tpy-M-tpy) connectivity.	Copper	43-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-29
31820187-0	2020	MicroRNA-214 targets COX-2 to antagonize indoxyl sulfate (IS)-induced endothelial cell apoptosis.	Indican	41-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-26
31820187-0	2020	MicroRNA-214 targets COX-2 to antagonize indoxyl sulfate (IS)-induced endothelial cell apoptosis.	Indican	58-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-26
31820187-7	2020	Meanwhile, COX-2 was upregulated at both mRNA and protein levels along with increased secretion of PGE2 in medium.	Dinoprostone	99-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-16
31820187-9	2020	Further analyses confirmed that COX-2 is a target gene of miR-214, and the inhibition of COX-2 by a specific COX-2 inhibitor NS-398 strikingly attenuated IS-induced endothelial cell apoptosis along with a significant blockade of PGE2 secretion.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	125-131	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-37
31820187-9	2020	Further analyses confirmed that COX-2 is a target gene of miR-214, and the inhibition of COX-2 by a specific COX-2 inhibitor NS-398 strikingly attenuated IS-induced endothelial cell apoptosis along with a significant blockade of PGE2 secretion.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	125-131	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-94
31820187-9	2020	Further analyses confirmed that COX-2 is a target gene of miR-214, and the inhibition of COX-2 by a specific COX-2 inhibitor NS-398 strikingly attenuated IS-induced endothelial cell apoptosis along with a significant blockade of PGE2 secretion.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	125-131	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-94
31820187-9	2020	Further analyses confirmed that COX-2 is a target gene of miR-214, and the inhibition of COX-2 by a specific COX-2 inhibitor NS-398 strikingly attenuated IS-induced endothelial cell apoptosis along with a significant blockade of PGE2 secretion.	Dinoprostone	229-233	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-37
31820187-9	2020	Further analyses confirmed that COX-2 is a target gene of miR-214, and the inhibition of COX-2 by a specific COX-2 inhibitor NS-398 strikingly attenuated IS-induced endothelial cell apoptosis along with a significant blockade of PGE2 secretion.	Dinoprostone	229-233	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-94
31820187-9	2020	Further analyses confirmed that COX-2 is a target gene of miR-214, and the inhibition of COX-2 by a specific COX-2 inhibitor NS-398 strikingly attenuated IS-induced endothelial cell apoptosis along with a significant blockade of PGE2 secretion.	Dinoprostone	229-233	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-94
31820187-10	2020	In conclusion, this study demonstrated an important role of miR-214 in protecting against endothelial cell damage induced by IS possibly by direct downregulation of COX-2/PGE2 axis.	Dinoprostone	171-175	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	165-170
31832781-0	2020	Mixed ligand complexes of Co(II), Ni(II) and Cu(II) with quercetin and diimine ligands: synthesis, characterization, anti-cancer and anti-oxidant activity.	Quercetin	57-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-32
31832781-1	2020	In this work, mixed ligand complexes of Co(II) Ni(II) and Cu(II) were synthesized using quercetin and diimine (1,10-phenanthroline or 2,2"-bipyiridine) ligands.	Copper	58-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-46
31832781-1	2020	In this work, mixed ligand complexes of Co(II) Ni(II) and Cu(II) were synthesized using quercetin and diimine (1,10-phenanthroline or 2,2"-bipyiridine) ligands.	Quercetin	88-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-46
31832781-1	2020	In this work, mixed ligand complexes of Co(II) Ni(II) and Cu(II) were synthesized using quercetin and diimine (1,10-phenanthroline or 2,2"-bipyiridine) ligands.	bis(salicylidene)diimine	102-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-46
31832781-1	2020	In this work, mixed ligand complexes of Co(II) Ni(II) and Cu(II) were synthesized using quercetin and diimine (1,10-phenanthroline or 2,2"-bipyiridine) ligands.	1,10-phenanthroline	111-130	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-46
31832781-1	2020	In this work, mixed ligand complexes of Co(II) Ni(II) and Cu(II) were synthesized using quercetin and diimine (1,10-phenanthroline or 2,2"-bipyiridine) ligands.	Aligeron	134-150	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-46
31832781-2	2020	The obtained Ni(II) and Co(II) complexes are new and the Cu(II) complexes are synthesized by different method from the literature.	Copper	57-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-30
31622816-4	2020	Herein, we successfully synthesize Co nanoparticles supported on three-dimensionally N-doped holey graphene aerogels hybrids by the high-temperature calcination of the graphene aerogels-polyallylamine-CoII hybrids.	12-(4'-azido-2'-nitrophenoxy)dodecanoyl-coenzyme A	35-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	201-205
31734378-2	2020	NSAIDs decrease prostaglandin synthesis through cyclooxygenase inhibition (COX-1 or COX-2).	Prostaglandins	16-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-89
32467688-0	2020	The effect of levocetirizine and montelukast on clinical symptoms, serum level and skin expression of COX-1 and COX-2 enzymes in patients suffering from chronic autoimmune urticaria - a pilot study.	levocetirizine	14-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-117
32467688-0	2020	The effect of levocetirizine and montelukast on clinical symptoms, serum level and skin expression of COX-1 and COX-2 enzymes in patients suffering from chronic autoimmune urticaria - a pilot study.	montelukast	33-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-117
32467688-11	2020	Conclusions: The effectiveness of levocetirizine and montelukast in treating CAU may be partly related to the reduction of COX-1 and COX-2 serum level and tissue expression, but further studies on a larger group of patients are needed to support this observation.	levocetirizine	34-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	133-138
32467688-11	2020	Conclusions: The effectiveness of levocetirizine and montelukast in treating CAU may be partly related to the reduction of COX-1 and COX-2 serum level and tissue expression, but further studies on a larger group of patients are needed to support this observation.	montelukast	53-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	133-138
31662136-6	2020	The mRNA level of the apoptosis-related gene Caspase-3 was significantly lower in the blastocysts derived from KAE-treated oocytes than in the control group and the mRNA expression of the embryo development-related genes COX2 and SOX2 was significantly increased in the KAE-treated group compared with that in the control group.	Kaempferols	111-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	221-225
31811862-0	2020	12-HETE is a regulator of PGE2 production via COX-2 expression induced by a snake venom group IIA phospholipase A2 in isolated peritoneal macrophages.	12-Hydroxy-5,8,10,14-eicosatetraenoic Acid	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
31811862-0	2020	12-HETE is a regulator of PGE2 production via COX-2 expression induced by a snake venom group IIA phospholipase A2 in isolated peritoneal macrophages.	Dinoprostone	26-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
31811862-3	2020	Among them, we highlight prostaglandin (PG)E2 produced by the cyclooxygenase (COX)-2 pathway, through activation of nuclear factor (NF)-kappaB.	Prostaglandins	25-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-84
31811862-3	2020	Among them, we highlight prostaglandin (PG)E2 produced by the cyclooxygenase (COX)-2 pathway, through activation of nuclear factor (NF)-kappaB.	Penicillin G	40-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-84
31811862-5	2020	This study investigates the regulatory mechanisms exerted by other groups of bioactive eicosanoids derived from 12-lipoxygenase (12-LO), in particular 12-hydroxyeicosatetraenoic (12-HETE), on group IIA sPLA2-induced (i) PGE2 release, (ii) COX-2 expression, and (iii) activation of signaling pathways p38 mitogen-activated protein kinases p38 mitogen-activated protein kinases (p38MAPK), protein C kinase (PKC), extracellular signal-regulated kinase 1/2 (ERK1/2), and NF-kappaB.	Eicosanoids	87-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	239-244
31811862-5	2020	This study investigates the regulatory mechanisms exerted by other groups of bioactive eicosanoids derived from 12-lipoxygenase (12-LO), in particular 12-hydroxyeicosatetraenoic (12-HETE), on group IIA sPLA2-induced (i) PGE2 release, (ii) COX-2 expression, and (iii) activation of signaling pathways p38 mitogen-activated protein kinases p38 mitogen-activated protein kinases (p38MAPK), protein C kinase (PKC), extracellular signal-regulated kinase 1/2 (ERK1/2), and NF-kappaB.	12-Hydroxy-5,8,10,14-eicosatetraenoic Acid	151-177	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	239-244
31811862-5	2020	This study investigates the regulatory mechanisms exerted by other groups of bioactive eicosanoids derived from 12-lipoxygenase (12-LO), in particular 12-hydroxyeicosatetraenoic (12-HETE), on group IIA sPLA2-induced (i) PGE2 release, (ii) COX-2 expression, and (iii) activation of signaling pathways p38 mitogen-activated protein kinases p38 mitogen-activated protein kinases (p38MAPK), protein C kinase (PKC), extracellular signal-regulated kinase 1/2 (ERK1/2), and NF-kappaB.	12-Hydroxy-5,8,10,14-eicosatetraenoic Acid	179-186	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	239-244
31811862-7	2020	Pre-treatment of these cells with baicalein, a 12-LO inhibitor, decreased the sPLA2-induced PGE2 production, significantly reduced COX-2 expression, and inhibited sPLA2-induced ERK; however, it did not affect p38MAPK or PKC phosphorylation.	baicalein	34-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-136
31811862-8	2020	In turn, sPLA2-induced PGE2 release and COX-2 expression, but not NF-kappaB activation, was attenuated by pre-treating macrophages with PD98059 an inhibitor of ERK1/2.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	136-143	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
31811862-9	2020	These results suggest that, in macrophages, group IIA sPLA2-induced PGE2 release and COX-2 protein expression are distinctly mediated through 12-HETE followed by ERK1/2 pathway activation, independently of NF-kappaB activation.	12-Hydroxy-5,8,10,14-eicosatetraenoic Acid	142-149	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-90
31811862-10	2020	These findings highlight an as yet undescribed mechanism by which 12-HETE regulates one of the distinct signaling pathways for snake venom group IIA sPLA2-induced PGE2 release and COX-2 expression in macrophages.	12-Hydroxy-5,8,10,14-eicosatetraenoic Acid	66-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	180-185
31910337-4	2020	In particular, Mn(II), Co(II), Ni(II), and Cu(II) were reported for the first time to form such large and discrete structures with (tpy-M-tpy) connectivity.	(2,2'-6',2'')-terpyridine	132-135	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-29
31910337-4	2020	In particular, Mn(II), Co(II), Ni(II), and Cu(II) were reported for the first time to form such large and discrete structures with (tpy-M-tpy) connectivity.	(2,2'-6',2'')-terpyridine	138-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-29
31991717-4	2020	In our experimental model, main carnosine beneficial effects were: (1) the modulation of nitric oxide production and metabolism; (2) the amelioration of the macrophage energy state; (3) the decrease of the expressions of pro-oxidant enzymes (Nox-2, Cox-2) and of the lipid peroxidation product malondialdehyde; (4) the restoration and/or increase of the expressions of antioxidant enzymes (Gpx1, SOD-2 and Cat); (5) the increase of the transforming growth factor-beta1 (TGF-beta1) and the down-regulation of the expressions of interleukins 1beta and 6 (IL-1beta and IL-6) and 6) the increase of the expressions of Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) and heme oxygenase-1 (HO-1).	Carnosine	32-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	249-254
31904036-1	2020	Six new Anderson-type polyoxometalate (POM)-based metal-organic complexes (MOCs), namely, {HCu(HPCAP)2[CrMo6(OH)6O18]} 2H2O (1), {Zn4(PCAP)2[CrMo6(OH)6O18]2(H2O)12} 4H2O (2), {Zn3(PCAP)2[CrMo6(OH)5O19](H2O)6} 6H2O (3), {Ni3(PCAP)2[NiMo6(OH)5O19](H2O)6} 8H2O (4), {Cu3(PCAP)2[AlMo6(OH)5O19](H2O)6} 6H2O (5), and {Co3(HPCAP)2[AlMo6(OH)6O18](H2O)10}[AlMo6(OH)6O18] 6H2O (6) (HPCAP = 3-(2-pyridinecarboxylic acid amido)pyridine), were constructed from diverse metal ions (CuII/ZnII/NiII/CoII), the HPCAP ligand and various Anderson-type POM anions under hydrothermal and solvothermal conditions and structurally characterized by single-crystal X-ray diffraction, IR spectroscopy, powder X-ray diffraction (PXRD) and thermogravimetric analyses (TGA).	polyoxometalate I	39-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	483-487
31904039-1	2020	A tridentate ligand L (2,6-bis(1-(3,5-di-tert-butylbenzyl)-1H-benzimidazol-2-yl)pyridine) was synthesized and used for the preparation of three pentacoordinated Co(ii) complexes of formula [Co(L)X2] (where X = NCS- for 1, X = Cl- for 2 and X = Br- for 3) and one ionic compound 4 ([Co(L)2]Br2 2CH3OH H2O) containing a hexacoordinated Co(ii) centre.	2,6-bis(benzimidazol-2-yl)pyridine	23-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	161-167
31904039-1	2020	A tridentate ligand L (2,6-bis(1-(3,5-di-tert-butylbenzyl)-1H-benzimidazol-2-yl)pyridine) was synthesized and used for the preparation of three pentacoordinated Co(ii) complexes of formula [Co(L)X2] (where X = NCS- for 1, X = Cl- for 2 and X = Br- for 3) and one ionic compound 4 ([Co(L)2]Br2 2CH3OH H2O) containing a hexacoordinated Co(ii) centre.	2,6-bis(benzimidazol-2-yl)pyridine	23-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	334-340
31904039-1	2020	A tridentate ligand L (2,6-bis(1-(3,5-di-tert-butylbenzyl)-1H-benzimidazol-2-yl)pyridine) was synthesized and used for the preparation of three pentacoordinated Co(ii) complexes of formula [Co(L)X2] (where X = NCS- for 1, X = Cl- for 2 and X = Br- for 3) and one ionic compound 4 ([Co(L)2]Br2 2CH3OH H2O) containing a hexacoordinated Co(ii) centre.	12-(4'-azido-2'-nitrophenoxy)dodecanoyl-coenzyme A	190-197	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	161-167
31904039-1	2020	A tridentate ligand L (2,6-bis(1-(3,5-di-tert-butylbenzyl)-1H-benzimidazol-2-yl)pyridine) was synthesized and used for the preparation of three pentacoordinated Co(ii) complexes of formula [Co(L)X2] (where X = NCS- for 1, X = Cl- for 2 and X = Br- for 3) and one ionic compound 4 ([Co(L)2]Br2 2CH3OH H2O) containing a hexacoordinated Co(ii) centre.	12-(4'-azido-2'-nitrophenoxy)dodecanoyl-coenzyme A	190-197	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	334-340
31904039-1	2020	A tridentate ligand L (2,6-bis(1-(3,5-di-tert-butylbenzyl)-1H-benzimidazol-2-yl)pyridine) was synthesized and used for the preparation of three pentacoordinated Co(ii) complexes of formula [Co(L)X2] (where X = NCS- for 1, X = Cl- for 2 and X = Br- for 3) and one ionic compound 4 ([Co(L)2]Br2 2CH3OH H2O) containing a hexacoordinated Co(ii) centre.	3-bromoacetoxyandrostan-17-one	244-246	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	161-167
31904039-1	2020	A tridentate ligand L (2,6-bis(1-(3,5-di-tert-butylbenzyl)-1H-benzimidazol-2-yl)pyridine) was synthesized and used for the preparation of three pentacoordinated Co(ii) complexes of formula [Co(L)X2] (where X = NCS- for 1, X = Cl- for 2 and X = Br- for 3) and one ionic compound 4 ([Co(L)2]Br2 2CH3OH H2O) containing a hexacoordinated Co(ii) centre.	3-bromoacetoxyandrostan-17-one	244-246	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	334-340
31904039-1	2020	A tridentate ligand L (2,6-bis(1-(3,5-di-tert-butylbenzyl)-1H-benzimidazol-2-yl)pyridine) was synthesized and used for the preparation of three pentacoordinated Co(ii) complexes of formula [Co(L)X2] (where X = NCS- for 1, X = Cl- for 2 and X = Br- for 3) and one ionic compound 4 ([Co(L)2]Br2 2CH3OH H2O) containing a hexacoordinated Co(ii) centre.	boroglycine	280-304	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	161-167
31904039-1	2020	A tridentate ligand L (2,6-bis(1-(3,5-di-tert-butylbenzyl)-1H-benzimidazol-2-yl)pyridine) was synthesized and used for the preparation of three pentacoordinated Co(ii) complexes of formula [Co(L)X2] (where X = NCS- for 1, X = Cl- for 2 and X = Br- for 3) and one ionic compound 4 ([Co(L)2]Br2 2CH3OH H2O) containing a hexacoordinated Co(ii) centre.	boroglycine	280-304	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	334-340
31872199-0	2020	Slow magnetic relaxation in CoII-LnIII heterodinuclear complexes achieved through a functionalized nitronyl nitroxide biradical.	nitroxide maleimide	99-117	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-32
31872199-1	2020	A new nitronyl nitroxide biradical ligand NITPh-PyPzbis (5-(3-(2-pyridinyl)-1H-pyrazol-1-yl)-1,3-bis(1"-oxyl-3"-oxido-4",4",5",5"-tetramethyl-4,5-hydro-1H-imidazol-2-yl)benzene) has been successfully applied for constructing a 3d-4f CoII-LnIII system, giving rise to a family of novel hetero-tri-spin complexes, namely, [LnCo(hfac)5(NITPh-PyPzbis)] CH2Cl2 (LnCo = YCo 1, GdCo 2, TbCo 3, DyCo 4, and HoCo 5; hfac = hexafluoroacetylacetonate).	nitroxide maleimide	6-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	233-237
31872199-1	2020	A new nitronyl nitroxide biradical ligand NITPh-PyPzbis (5-(3-(2-pyridinyl)-1H-pyrazol-1-yl)-1,3-bis(1"-oxyl-3"-oxido-4",4",5",5"-tetramethyl-4,5-hydro-1H-imidazol-2-yl)benzene) has been successfully applied for constructing a 3d-4f CoII-LnIII system, giving rise to a family of novel hetero-tri-spin complexes, namely, [LnCo(hfac)5(NITPh-PyPzbis)] CH2Cl2 (LnCo = YCo 1, GdCo 2, TbCo 3, DyCo 4, and HoCo 5; hfac = hexafluoroacetylacetonate).	pyrrole triamide	42-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	233-237
31872199-2	2020	In these hetero-tri-spin complexes, the NITPh-PyPzbis biradical chelates one LnIII and one CoII simultaneously by means of its adjacent aminoxyl moieties and two N donors from the 3-(2-pyridinyl)-1H-pyrazol-1-yl unit, respectively, realizing the unique biradical-Co-Ln heterodinuclear structure.	nitph	40-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-95
31872199-2	2020	In these hetero-tri-spin complexes, the NITPh-PyPzbis biradical chelates one LnIII and one CoII simultaneously by means of its adjacent aminoxyl moieties and two N donors from the 3-(2-pyridinyl)-1H-pyrazol-1-yl unit, respectively, realizing the unique biradical-Co-Ln heterodinuclear structure.	aminoxyl	136-144	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-95
31872199-2	2020	In these hetero-tri-spin complexes, the NITPh-PyPzbis biradical chelates one LnIII and one CoII simultaneously by means of its adjacent aminoxyl moieties and two N donors from the 3-(2-pyridinyl)-1H-pyrazol-1-yl unit, respectively, realizing the unique biradical-Co-Ln heterodinuclear structure.	1-(2-fluoro-4-(1H-pyrazol-1-yl)phenyl)-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one	180-211	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-95
31872199-2	2020	In these hetero-tri-spin complexes, the NITPh-PyPzbis biradical chelates one LnIII and one CoII simultaneously by means of its adjacent aminoxyl moieties and two N donors from the 3-(2-pyridinyl)-1H-pyrazol-1-yl unit, respectively, realizing the unique biradical-Co-Ln heterodinuclear structure.	bis(citric acid)lanthanum(III)	263-268	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-95
31979339-4	2020	Thus, 58 2-arylbenzofurans were initially screened through molecular docking within the active site of nine COX-2 crystal structures.	Aligeron	9-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-113
31979339-8	2020	Therefore, four hits are proposed as lead structures for the development of COX-2 inhibitors based on 2-arylbenzofurans in further studies.	Aligeron	102-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-81
31848544-1	2020	Blue crystals of five heteroleptic cobalt(ii) silanethiolates 1-5 have been obtained by the reaction of [Co{SSi(tBuO)3}2(NH3)]2 with aminopyridines and aminomethylpyridines at an appropriate molar ratio and their structural, spectral, thermal and magnetic properties have been established and described.	N-isobutylidenedipivalamide	104-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-44
31804064-3	2020	After addition of target Hg2+, the Exonuclease III (Exo-III) digestion is initiated to liberate DNA "key" (K), thereby, the free K triggers strand displacement reaction for exposing the prelocked N3 to successfully ligate with dibenzocyclooctyne (DBCO)-tagged anchor via metal-catalyst-free click chemistry, in which amounts of 2D MOF nanosheets containing Co(II) as electron mediator are introduced accompanying with significant electrochemical response.	Mercury	25-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	357-363
31804064-3	2020	After addition of target Hg2+, the Exonuclease III (Exo-III) digestion is initiated to liberate DNA "key" (K), thereby, the free K triggers strand displacement reaction for exposing the prelocked N3 to successfully ligate with dibenzocyclooctyne (DBCO)-tagged anchor via metal-catalyst-free click chemistry, in which amounts of 2D MOF nanosheets containing Co(II) as electron mediator are introduced accompanying with significant electrochemical response.	dibenzocyclooctyne	227-245	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	357-363
31804064-3	2020	After addition of target Hg2+, the Exonuclease III (Exo-III) digestion is initiated to liberate DNA "key" (K), thereby, the free K triggers strand displacement reaction for exposing the prelocked N3 to successfully ligate with dibenzocyclooctyne (DBCO)-tagged anchor via metal-catalyst-free click chemistry, in which amounts of 2D MOF nanosheets containing Co(II) as electron mediator are introduced accompanying with significant electrochemical response.	2,8-Dibenzylcyclooctanone	247-251	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	357-363
31848544-1	2020	Blue crystals of five heteroleptic cobalt(ii) silanethiolates 1-5 have been obtained by the reaction of [Co{SSi(tBuO)3}2(NH3)]2 with aminopyridines and aminomethylpyridines at an appropriate molar ratio and their structural, spectral, thermal and magnetic properties have been established and described.	Aminopyridines	133-147	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-44
31848544-1	2020	Blue crystals of five heteroleptic cobalt(ii) silanethiolates 1-5 have been obtained by the reaction of [Co{SSi(tBuO)3}2(NH3)]2 with aminopyridines and aminomethylpyridines at an appropriate molar ratio and their structural, spectral, thermal and magnetic properties have been established and described.	3,5-diethoxy-4-aminomethylpyridine	152-172	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-44
31750451-3	2020	Here, we have cataloged the cyclic voltammetric properties of the solvento complexes of Mn(ii), Fe(ii), Co(ii), Ni(ii), Cu(i), and Zn(ii) in acetonitrile electrolyte, providing information on the cathodic electrodeposition and anodic stripping processes occuring with each ion.	acetonitrile	141-153	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-93
31750451-3	2020	Here, we have cataloged the cyclic voltammetric properties of the solvento complexes of Mn(ii), Fe(ii), Co(ii), Ni(ii), Cu(i), and Zn(ii) in acetonitrile electrolyte, providing information on the cathodic electrodeposition and anodic stripping processes occuring with each ion.	acetonitrile	141-153	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-101
31750451-3	2020	Here, we have cataloged the cyclic voltammetric properties of the solvento complexes of Mn(ii), Fe(ii), Co(ii), Ni(ii), Cu(i), and Zn(ii) in acetonitrile electrolyte, providing information on the cathodic electrodeposition and anodic stripping processes occuring with each ion.	acetonitrile	141-153	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-110
31750451-3	2020	Here, we have cataloged the cyclic voltammetric properties of the solvento complexes of Mn(ii), Fe(ii), Co(ii), Ni(ii), Cu(i), and Zn(ii) in acetonitrile electrolyte, providing information on the cathodic electrodeposition and anodic stripping processes occuring with each ion.	acetonitrile	141-153	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-101
31750451-3	2020	Here, we have cataloged the cyclic voltammetric properties of the solvento complexes of Mn(ii), Fe(ii), Co(ii), Ni(ii), Cu(i), and Zn(ii) in acetonitrile electrolyte, providing information on the cathodic electrodeposition and anodic stripping processes occuring with each ion.	acetonitrile	141-153	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-101
31905343-7	2020	In addition, we demonstrated that the enhanced effect of aspirin on the cisplatin-induced inhibition of tumor cell growth was also mediated through the suppression of the binding activity of NF-kappaB to the COX-2 promoter.	Aspirin	57-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	208-213
32021549-3	2020	For the production of PGs cyclooxygenase is a necessary enzyme that has two isoforms, that are named COX-1 and COX-2.	Prostaglandins	22-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	111-116
32021549-4	2020	COX-1 produces type 1 prostaglandins and on the other hand, COX-2 produces type 2 prostaglandins.	Prostaglandins	82-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-65
32021288-13	2020	Besides, Brv-A has also been documented for inhibition of cell migration via decrease in COX-2 and MMP-2 expression.	brevilin A	9-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-94
31936620-0	2020	The Structural and Magnetic Properties of FeII and CoII Complexes with 2-(furan-2-yl)-5-pyridin-2-yl-1,3,4-oxadiazole.	5-(2-chloro-3,5-bis(trifluoromethyl)phenyl)-4-((4-(2,6-difluorophenyl)pyridin-3-yl)methyl)-3-(furan-2-yl)-4,5-dihydro-1,2,4-oxadiazole	71-117	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-55
31936226-1	2020	The combinations of Co(II), octacyanidotungstate(V), and monodentate pyridine N-oxide (pyNO) or 4-phenylpyridine N-oxide (4-phpyNO) led to crystallization of novel crystalline phases {CoII[CoII8(pyNO)12(MeOH)12][WV(CN)8]6} (1) and {CoII[CoII8(4-phpyNO)7(MeOH)17][WV(CN)8]6} 7MeOH (4-phpyNO)3 (2).	pyridine N-oxide	69-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	184-188
31936226-1	2020	The combinations of Co(II), octacyanidotungstate(V), and monodentate pyridine N-oxide (pyNO) or 4-phenylpyridine N-oxide (4-phpyNO) led to crystallization of novel crystalline phases {CoII[CoII8(pyNO)12(MeOH)12][WV(CN)8]6} (1) and {CoII[CoII8(4-phpyNO)7(MeOH)17][WV(CN)8]6} 7MeOH (4-phpyNO)3 (2).	pyridine N-oxide	69-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	189-193
31905343-0	2020	Aspirin enhances the sensitivity of colon cancer cells to cisplatin by abrogating the binding of NF-kappaB to the COX-2 promoter.	Aspirin	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-119
31905343-0	2020	Aspirin enhances the sensitivity of colon cancer cells to cisplatin by abrogating the binding of NF-kappaB to the COX-2 promoter.	Cisplatin	58-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-119
31841322-3	2020	The organic ligands coordinate equatorially to the two CoII ions via two bidentate (O,S) N-acylthiourea moieties and tridentate to the central Ln ion via the (O,N,O) 2,6-dipicolinoyl moieties.	Sulfur	83-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-59
31841322-3	2020	The organic ligands coordinate equatorially to the two CoII ions via two bidentate (O,S) N-acylthiourea moieties and tridentate to the central Ln ion via the (O,N,O) 2,6-dipicolinoyl moieties.	Superoxides	159-164	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-59
31841322-3	2020	The organic ligands coordinate equatorially to the two CoII ions via two bidentate (O,S) N-acylthiourea moieties and tridentate to the central Ln ion via the (O,N,O) 2,6-dipicolinoyl moieties.	N(alpha)-dipicolinoyl-bis(leucyl-norvaline methyl ester)	166-182	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-59
31841322-4	2020	Two acetate bridges established between each of the terminal Co and central Ln ions complete the square-pyramidal coordination spheres of CoII.	Acetates	4-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	138-142
31841322-7	2020	The nature of the magnetic interactions between the LnIII ions and the CoII ions in the "CoLnCo" complexes is deduced by comparing their chiMT values to the sum of chiMT values of the analogous "CoLaCo" and related "ZnLnZn" complexes.	Zinc	216-222	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-75
31905343-7	2020	In addition, we demonstrated that the enhanced effect of aspirin on the cisplatin-induced inhibition of tumor cell growth was also mediated through the suppression of the binding activity of NF-kappaB to the COX-2 promoter.	Cisplatin	72-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	208-213
31905343-8	2020	The combination of aspirin and cisplatin effectively attenuated the translocation of NF-kappaB p65/p50 from the cytoplasm to the nucleus, and abrogated the binding of NF-kappaB p65/p50 to the COX-2 promoter, thereby down-regulating COX-2 expression and PGE2 synthesis.	Aspirin	19-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	192-197
31905343-8	2020	The combination of aspirin and cisplatin effectively attenuated the translocation of NF-kappaB p65/p50 from the cytoplasm to the nucleus, and abrogated the binding of NF-kappaB p65/p50 to the COX-2 promoter, thereby down-regulating COX-2 expression and PGE2 synthesis.	Aspirin	19-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	232-237
31905343-8	2020	The combination of aspirin and cisplatin effectively attenuated the translocation of NF-kappaB p65/p50 from the cytoplasm to the nucleus, and abrogated the binding of NF-kappaB p65/p50 to the COX-2 promoter, thereby down-regulating COX-2 expression and PGE2 synthesis.	Cisplatin	31-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	192-197
31905343-8	2020	The combination of aspirin and cisplatin effectively attenuated the translocation of NF-kappaB p65/p50 from the cytoplasm to the nucleus, and abrogated the binding of NF-kappaB p65/p50 to the COX-2 promoter, thereby down-regulating COX-2 expression and PGE2 synthesis.	Cisplatin	31-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	232-237
31833500-1	2020	A newly discovered isomer of Co(ii) (1,4,8,11-tetrakis(carbamoylmethyl)-1,4,8,11-tetraazacyclotetradecane = CCRM) produces four highly paramagnetically shifted chemical exchange saturation transfer (CEST) peaks.	cyclam	37-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-35
31921452-1	2020	The title homoleptic Schiff base complexes, [M(C14H9Cl2N2O)2], for M = CoII, (I), and CuII, (II), present distinct coordination geometries despite the Schiff base dianion coordinating via the phenolato-O and imine-N atoms in each case.	Schiff Bases	21-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-75
31947805-0	2020	A Pair of CoII Supramolecular Isomers Based on Flexible Bis-Pyridyl-Bis-Amide and Angular Dicarboxylate Ligands.	bis-pyridyl-bis-amide	56-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-14
31947805-0	2020	A Pair of CoII Supramolecular Isomers Based on Flexible Bis-Pyridyl-Bis-Amide and Angular Dicarboxylate Ligands.	malonic acid	90-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-14
31921452-1	2020	The title homoleptic Schiff base complexes, [M(C14H9Cl2N2O)2], for M = CoII, (I), and CuII, (II), present distinct coordination geometries despite the Schiff base dianion coordinating via the phenolato-O and imine-N atoms in each case.	dichlorodiethylbis(pyridine-N)tin(IV)	45-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-75
31921452-1	2020	The title homoleptic Schiff base complexes, [M(C14H9Cl2N2O)2], for M = CoII, (I), and CuII, (II), present distinct coordination geometries despite the Schiff base dianion coordinating via the phenolato-O and imine-N atoms in each case.	Schiff Bases	21-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-75
31708230-7	2020	Although the indolizine bearing derivatives 8-11b exhibited higher selectivity to COX-2 than their corresponding pyrrolizine analogs 8-11a, but they were less active and selective against MCF-7 cells.	indolizine	13-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
32468468-7	2020	Molecular docking studies showed that compound 3 m exhibited good binding affinity against COX-2 with docking score 9.328 kcal/mol, when compared to the standard celecoxib.	Celecoxib	162-171	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-96
31878864-7	2020	RESULTS: Briefly, the COX-2 inhibitory relative activity was found to be in between the range of 80-92 % (Diclofenac showed 84 %, IC50 0.95 microM).	Diclofenac	106-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-27
32294047-12	2020	CONCLUSION: The effectiveness of JS-PFA in our studies suggests targeting PDGF by COX 2 inhibitor can serve as a novel treatment strategy for the treatment of HCC.	js-pfa	33-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
31711766-0	2020	Corrigendum to "Synthesis and biological evaluation of tetrazole derivatives as TNF-alpha, IL-6 and COX-2 inhibitors with antimicrobial activity: Computational analysis, molecular modeling study and region-specific cyclization using 2D NMR tools" [Bioorg.	Tetrazoles	55-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-105
31838289-0	2020	New pyridazine derivatives as selective COX-2 inhibitors and potential anti-inflammatory agents; design, synthesis and biological evaluation.	pyridazine	4-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
31838289-11	2020	Furthermore, the selective COX-2 inhibitor 3g exhibited a superior gastrointestinal safety profile compared to the reference drugs celecoxib and indomethacin with less number of ulcers and milder ulcer score.	celecoxib	131-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-32
31796215-0	2020	Synthesis and discovery of pyrazolo-pyridine analogs as inflammation medications through pro- and anti-inflammatory cytokine and COX-2 inhibition assessments.	pyrazolo(3,4-b)pyridine	27-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-134
31838289-11	2020	Furthermore, the selective COX-2 inhibitor 3g exhibited a superior gastrointestinal safety profile compared to the reference drugs celecoxib and indomethacin with less number of ulcers and milder ulcer score.	Indomethacin	145-157	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-32
31838289-12	2020	The molecular docking study of this compound with COX-2 protein revealed more favorable binding mode compared to celecoxib, explaining its remarkable COX-2 inhibitory potency.	celecoxib	113-122	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-55
31796215-6	2020	In the results, among the 12-member family of pyrazolo-pyridines (5a-l), 5a, 5b, 5g, and 5j were showed excellent in silico binding affinity (1-10 nM), least binding energy (-12.45 to -14.27 kcal/mol) and in vitro COX-2 inhibition (relative percentage activity maximum 96.42%).	pyrazolo(3,4-b)pyridine	46-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	214-219
31911297-1	2020	New series of pyrazole derivatives Va-c, VIa-c, VIIa-f, and VIII possessing amino/methanesulphonyl moiety as COX-2 pharmacophore were designed and synthesized.	Pyrazoles	14-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-114
31911297-1	2020	New series of pyrazole derivatives Va-c, VIa-c, VIIa-f, and VIII possessing amino/methanesulphonyl moiety as COX-2 pharmacophore were designed and synthesized.	Amino Acids	76-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-114
31911297-1	2020	New series of pyrazole derivatives Va-c, VIa-c, VIIa-f, and VIII possessing amino/methanesulphonyl moiety as COX-2 pharmacophore were designed and synthesized.	S-methanesulfonyl coenzyme A	82-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-114
31911297-3	2020	Compounds Va, VIa, VIc and VIIa-c showed good COX-2 SI (246.8-353.8) in comparison with the COX-2 selective drug; celecoxib (326.7).	2-amino-3,3'-difluoroisobutyric acid	19-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
31838289-12	2020	The molecular docking study of this compound with COX-2 protein revealed more favorable binding mode compared to celecoxib, explaining its remarkable COX-2 inhibitory potency.	celecoxib	113-122	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	150-155
31911297-3	2020	Compounds Va, VIa, VIc and VIIa-c showed good COX-2 SI (246.8-353.8) in comparison with the COX-2 selective drug; celecoxib (326.7).	2-amino-3,3'-difluoroisobutyric acid	19-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-97
31016540-8	2020	The patients who consumed selective COX-2 inhibitors needed less rescue analgesia after 24 h. The occurrence of one or more adverse events was similar in both groups, though patients who consumed ibuprofen had more nausea and vomiting.	Ibuprofen	196-205	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-41
32741915-1	2020	Five new series of hydroxybenzofuranyl-pyrazolyl chalcones 3a,b, hydroxyphenyl-pyrazolyl chalcones 6a-c and their corresponding pyrazolylpyrazolines 4a, d, 7a-c and 8a-f have been synthesized and evaluated for their in vitro cyclooxygenase (COX)-1 and COX-2 inhibitory activity.	hydroxybenzofuranyl-pyrazolyl chalcones	19-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	252-257
31935603-6	2020	Co(II) complex (1) exhibited enhanced catecholase activity with Kcat = 213.48 h-1, which is attributed to the greater extent of charge contribution on Co2+ as compared to Cu2+ as determined by DFT calculations.	12-(4'-azido-2'-nitrophenoxy)dodecanoyl-coenzyme A	151-155	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
31935603-6	2020	Co(II) complex (1) exhibited enhanced catecholase activity with Kcat = 213.48 h-1, which is attributed to the greater extent of charge contribution on Co2+ as compared to Cu2+ as determined by DFT calculations.	Copper	171-175	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
32741915-3	2020	The pyrazolylpyrazolines 4a-d and 8a-f bearing two vicinal aryl moieties in the pyrazoline nucleus showed more selectivity towards COX-2.	pyrazolylpyrazolines	4-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-136
32741915-3	2020	The pyrazolylpyrazolines 4a-d and 8a-f bearing two vicinal aryl moieties in the pyrazoline nucleus showed more selectivity towards COX-2.	and 8a-f	30-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-136
32741915-3	2020	The pyrazolylpyrazolines 4a-d and 8a-f bearing two vicinal aryl moieties in the pyrazoline nucleus showed more selectivity towards COX-2.	aryl	59-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-136
32741915-3	2020	The pyrazolylpyrazolines 4a-d and 8a-f bearing two vicinal aryl moieties in the pyrazoline nucleus showed more selectivity towards COX-2.	pyrazoline	13-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-136
32741915-7	2020	In addition, to explore the binding mode and selectivity of our compounds, 8d and celecoxib were docked into the active site of COX-1 and COX-2.	Celecoxib	82-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	138-143
32741915-8	2020	It was found that compound 8d exhibited a binding pattern and interactions similar to that of celecoxib with COX-2 active site, while bitter manner of interaction than celecoxib to COX-1 active site.	Celecoxib	94-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-114
30686258-0	2020	Cinnamaldehyde Analogs: Docking Based Optimization, COX-2 Inhibitory in vivo and in vitro Studies.	cinnamaldehyde	0-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-57
31985369-9	2020	Hence, in vitro COX-2 inhibitory assay performed for epicatechin, daidzein and compared with known analgesic agent diclofenac revealed a pronounced dose dependent inhibitory activity.	Catechin	53-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-21
31985369-9	2020	Hence, in vitro COX-2 inhibitory assay performed for epicatechin, daidzein and compared with known analgesic agent diclofenac revealed a pronounced dose dependent inhibitory activity.	daidzein	66-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-21
31985369-9	2020	Hence, in vitro COX-2 inhibitory assay performed for epicatechin, daidzein and compared with known analgesic agent diclofenac revealed a pronounced dose dependent inhibitory activity.	Diclofenac	115-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-21
31820176-3	2020	The inducible cyclooxygenase, COX-2, is largely responsible for most PGE2 production in bone, and once released, PGE2 is rapidly degraded in vivo.	Dinoprostone	69-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-35
31832938-0	2020	Facile fabrication of magnetic phosphorylated chitosan for the removal of Co(II) in water treatment: separation properties and adsorption mechanisms.	Water	84-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-80
31832938-3	2020	The adsorption isotherms and kinetic models of Co(II) by P-MCS followed the Langmuir model and the pseudo-second-order model, respectively.	phenylmercuric chloride	57-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-53
31832938-6	2020	The results of spectroscopic analysis also indicated that good adsorption performance of Co(II) mainly depends on surface chelation between functional groups and metal ions.	Metals	162-167	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-95
31838698-7	2020	The relatively large surface area as estimated from N2 adsorption makes the nanopowders very favorable for the uptake Cd(II), Cr (IV), Co (II) and Ni(II) from aqueous solution.	Nitrogen	52-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-153
31838698-7	2020	The relatively large surface area as estimated from N2 adsorption makes the nanopowders very favorable for the uptake Cd(II), Cr (IV), Co (II) and Ni(II) from aqueous solution.	Cadmium	118-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-153
31820176-3	2020	The inducible cyclooxygenase, COX-2, is largely responsible for most PGE2 production in bone, and once released, PGE2 is rapidly degraded in vivo.	Dinoprostone	113-117	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-35
31820176-4	2020	COX-2 is induced by multiple agonists - hormones, growth factors, and proinflammatory factors - and the resulting PGE2 may mediate, amplify, or, as we have recently shown for parathyroid hormone (PTH), inhibit responses to these agonists.	Dinoprostone	114-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
31693860-5	2020	Pan-HDACi suberoylanilide hydroxamic acid (SAHA) and/or ITF2357 (givinostat) significantly reduced TNFalpha- and P. gingivalis-inducible expression and/or production of a cluster of inflammatory mediators in healthy donor GFs (IL1B, CCL2, CCL5, CXCL10, COX2, and MMP3) without affecting cell viability.	vorinostat	10-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	253-257
31752003-7	2020	Plasma histamine levels were significantly correlated with the culprit drug selectivity for cyclooxygenase (COX) isozymes (p < 0.001), with higher levels being obtained in patients reporting reactions to COX-1 than to COX-2 selective inhibitors (p < 0.05).	Histamine	7-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	218-223
30678546-0	2020	DNA binding and cleavage, cytotoxicity and antimicrobial studies of Co(II), Ni(II), Cu(II) and Zn(II) complexes of 1-((E)-(4-(trifluoromethoxy)phenylimino)methyl)naphthalen-2-ol Schiff base.	1-((e)-(4-(trifluoromethoxy)phenylimino)methyl)naphthalen-2-ol schiff base	115-189	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-74
31693860-5	2020	Pan-HDACi suberoylanilide hydroxamic acid (SAHA) and/or ITF2357 (givinostat) significantly reduced TNFalpha- and P. gingivalis-inducible expression and/or production of a cluster of inflammatory mediators in healthy donor GFs (IL1B, CCL2, CCL5, CXCL10, COX2, and MMP3) without affecting cell viability.	vorinostat	43-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	253-257
31693860-5	2020	Pan-HDACi suberoylanilide hydroxamic acid (SAHA) and/or ITF2357 (givinostat) significantly reduced TNFalpha- and P. gingivalis-inducible expression and/or production of a cluster of inflammatory mediators in healthy donor GFs (IL1B, CCL2, CCL5, CXCL10, COX2, and MMP3) without affecting cell viability.	givinostat hydrochloride	56-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	253-257
31693860-5	2020	Pan-HDACi suberoylanilide hydroxamic acid (SAHA) and/or ITF2357 (givinostat) significantly reduced TNFalpha- and P. gingivalis-inducible expression and/or production of a cluster of inflammatory mediators in healthy donor GFs (IL1B, CCL2, CCL5, CXCL10, COX2, and MMP3) without affecting cell viability.	givinostat	65-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	253-257
32368976-6	2020	Naproxen shows its activity by inhibiting the COX2 enzyme.	Naproxen	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-50
31664161-1	2020	Cyclooxygenase-2 [(COX-2) or prostaglandin endoperoxide H2 synthase-2 (PTGS-2)] induces the production of prostaglandins as part of the host-immune response to infections.	Prostaglandins	106-120	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-24
31698185-0	2020	Zn(II) and Co(II) derivatives anchored with scorpionate precursor: Antiproliferative evaluation in human cancer cell lines.	tris(hydroxymethyl)phosphine	44-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-17
31698185-1	2020	A "scorpionate" type precursor [bdtbpza = bis(3,5-di-t-butylpyrazol-1-yl)acetate] has been employed to synthesize two mononuclear ZnII and CoII derivatives, namely [Zn(bdtbpza)2 (H2O)2] 2.5CH3OH 2[(CH3)3C-C3H2N2-C(CH3)3] (1) and [Co(bdtbpza)2(CH3OH)4] (2) in good yield.	tris(hydroxymethyl)phosphine	3-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-143
31698185-1	2020	A "scorpionate" type precursor [bdtbpza = bis(3,5-di-t-butylpyrazol-1-yl)acetate] has been employed to synthesize two mononuclear ZnII and CoII derivatives, namely [Zn(bdtbpza)2 (H2O)2] 2.5CH3OH 2[(CH3)3C-C3H2N2-C(CH3)3] (1) and [Co(bdtbpza)2(CH3OH)4] (2) in good yield.	bis(3,5-di-tert-butylpyrazol-1-yl)dithioacetate	42-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-143
31698185-1	2020	A "scorpionate" type precursor [bdtbpza = bis(3,5-di-t-butylpyrazol-1-yl)acetate] has been employed to synthesize two mononuclear ZnII and CoII derivatives, namely [Zn(bdtbpza)2 (H2O)2] 2.5CH3OH 2[(CH3)3C-C3H2N2-C(CH3)3] (1) and [Co(bdtbpza)2(CH3OH)4] (2) in good yield.	Zinc	130-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-143
31698185-1	2020	A "scorpionate" type precursor [bdtbpza = bis(3,5-di-t-butylpyrazol-1-yl)acetate] has been employed to synthesize two mononuclear ZnII and CoII derivatives, namely [Zn(bdtbpza)2 (H2O)2] 2.5CH3OH 2[(CH3)3C-C3H2N2-C(CH3)3] (1) and [Co(bdtbpza)2(CH3OH)4] (2) in good yield.	Zinc	165-177	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-143
31698185-1	2020	A "scorpionate" type precursor [bdtbpza = bis(3,5-di-t-butylpyrazol-1-yl)acetate] has been employed to synthesize two mononuclear ZnII and CoII derivatives, namely [Zn(bdtbpza)2 (H2O)2] 2.5CH3OH 2[(CH3)3C-C3H2N2-C(CH3)3] (1) and [Co(bdtbpza)2(CH3OH)4] (2) in good yield.	Water	179-182	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-143
31698185-1	2020	A "scorpionate" type precursor [bdtbpza = bis(3,5-di-t-butylpyrazol-1-yl)acetate] has been employed to synthesize two mononuclear ZnII and CoII derivatives, namely [Zn(bdtbpza)2 (H2O)2] 2.5CH3OH 2[(CH3)3C-C3H2N2-C(CH3)3] (1) and [Co(bdtbpza)2(CH3OH)4] (2) in good yield.	N-methyl perfluorobutane sulfonamidoethanol	230-250	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-143
31698185-2	2020	Single crystal X-ray diffraction analysis reveals that in 1, the ZnII atom is tetrahedrally surrounded by a pair of Oacetate atoms of two bis(pyrazol-1-yl)acetate units and two water molecules; while in 2, the CoII atom shows an octahedral environment coordinating a pair of Oacetate atoms of two bis(pyrazol-1-yl)acetate units along with four methanol molecules.	Zinc	65-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	210-214
31706181-0	2020	New sulfonamide complexes with essential metal ions [Cu (II), Co (II), Ni (II) and Zn (II)].	Sulfonamides	4-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-91
30734682-3	2020	Ever since enrolment of COX-2, particularly overabundance of its main products prostaglandin E2 (PGE2) and thromboxane A2 (TXA2) in numerous pathological processes was recognized, it became significant therapeutic target.	Dinoprostone	79-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
30734682-3	2020	Ever since enrolment of COX-2, particularly overabundance of its main products prostaglandin E2 (PGE2) and thromboxane A2 (TXA2) in numerous pathological processes was recognized, it became significant therapeutic target.	Dinoprostone	97-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
30734682-9	2020	CONCLUSIONS: Some further structural modification of tested compounds and particularly synthesis of different trifluoromethyl imidazolines could contribute to development of new COX-2 inhibitors and potent anti-inflammatory agents.	trifluoromethyl imidazolines	110-138	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	178-183
32368977-3	2020	Novel synthesised Schiff"s base 2-methoxy-4-((3-methylpyridin-2-ylimino)methyl)phenol (SB) and its metal complexes (Zn[II], Cu[II], Co[II] and Ni[II]) were characterised by UV, IR and NMR spectroscopy.	schiff"s base 2-methoxy-4-((3-methylpyridin-2-ylimino)methyl)phenol	18-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-137
32368977-3	2020	Novel synthesised Schiff"s base 2-methoxy-4-((3-methylpyridin-2-ylimino)methyl)phenol (SB) and its metal complexes (Zn[II], Cu[II], Co[II] and Ni[II]) were characterised by UV, IR and NMR spectroscopy.	Antimony	87-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-137
32368977-4	2020	Formation of the Schiff base and the metal (Zn[II], Cu[II], Co[II] and Ni[II]) chelates was supported by spectral and analytical data.	Schiff Bases	17-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-65
32368977-4	2020	Formation of the Schiff base and the metal (Zn[II], Cu[II], Co[II] and Ni[II]) chelates was supported by spectral and analytical data.	Metals	37-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-65
31851937-2	2019	Insertion of copper into its catalytically active subunits, including COX2, is a complex process that requires metallochaperones and redox proteins including SCO1, SCO2, and COA6, a recently discovered protein whose molecular function is unknown.	Copper	13-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-74
31648572-7	2020	Abbreviations AKT protein kinase B ARMS alveolar rhabdomyosarcoma ATM ataxia telangiectasia mutated Bax Bcl-2-associated X protein Bcl-2 B-cell lymphoma 2 CDC2 cyclin-dependent kinase 2 Bcl-xL B-cell lymphoma-extra large c-FLIP cellular FLICE-like inhibitory protein CDDP cisplatin COX-2 cyclooxygenase-2 cyt c cytochrome c DNA-PKcs DNA-dependent protein kinase EGFR epidermal growth factor receptor EMT epithelial-mesenchymal transition ERK extracellular signal-regulated kinase ES Ewing`s sarcoma ETS2 erythroblastosis virus transcription factor 2 GBM glioblastoma multiforme HCC hepatocellular carcinoma HNSCC head and neck squamous cell carcinoma IAP inhibitor of apoptosis protein IkappaBalpha inhibitor of kappaB alpha IKK inhibitor of kappaB kinase IR ionizing radiation lncRNA long non-coding RNA luc luciferase Mcl-1 myeloid cell leukemia-1 MDR1 multidrug resistance protein 1 miR microRNA MMP-9 matrix metalloproteinase-9 mTOR mammalian target of rapamycin NB neuroblastoma NF-kappaB nuclear factor-kappaB NPC nasopharyngeal carcinoma NSCLC non-small cell lung cancer OSCC oral squamous cell carcinoma PARP poly-(ADP-ribose)-polymerase pH2AX phosphorylated histone 2AX-immunoreactive PI3K phosphatidylinositol 3-kinase Prp4K Pre-mRNA processing factor 4 kinase RCC renal cell carcinoma ROS reactive oxygen species SCC squamous cell carcinoma SLN solid lipid nanoparticle SOD2 superoxide dismutase 2 TERT telomerase reverse transcriptase TNF-alpha tumor necrosis factor-alpha TxnRd1 thioredoxin reductase-1 VEGF vascular endothelial growth factor XIAP X-linked inhibitor of apoptosis protein DeltaPsim mitochondrial membrane potential.	Cisplatin	267-281	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	282-287
31648572-7	2020	Abbreviations AKT protein kinase B ARMS alveolar rhabdomyosarcoma ATM ataxia telangiectasia mutated Bax Bcl-2-associated X protein Bcl-2 B-cell lymphoma 2 CDC2 cyclin-dependent kinase 2 Bcl-xL B-cell lymphoma-extra large c-FLIP cellular FLICE-like inhibitory protein CDDP cisplatin COX-2 cyclooxygenase-2 cyt c cytochrome c DNA-PKcs DNA-dependent protein kinase EGFR epidermal growth factor receptor EMT epithelial-mesenchymal transition ERK extracellular signal-regulated kinase ES Ewing`s sarcoma ETS2 erythroblastosis virus transcription factor 2 GBM glioblastoma multiforme HCC hepatocellular carcinoma HNSCC head and neck squamous cell carcinoma IAP inhibitor of apoptosis protein IkappaBalpha inhibitor of kappaB alpha IKK inhibitor of kappaB kinase IR ionizing radiation lncRNA long non-coding RNA luc luciferase Mcl-1 myeloid cell leukemia-1 MDR1 multidrug resistance protein 1 miR microRNA MMP-9 matrix metalloproteinase-9 mTOR mammalian target of rapamycin NB neuroblastoma NF-kappaB nuclear factor-kappaB NPC nasopharyngeal carcinoma NSCLC non-small cell lung cancer OSCC oral squamous cell carcinoma PARP poly-(ADP-ribose)-polymerase pH2AX phosphorylated histone 2AX-immunoreactive PI3K phosphatidylinositol 3-kinase Prp4K Pre-mRNA processing factor 4 kinase RCC renal cell carcinoma ROS reactive oxygen species SCC squamous cell carcinoma SLN solid lipid nanoparticle SOD2 superoxide dismutase 2 TERT telomerase reverse transcriptase TNF-alpha tumor necrosis factor-alpha TxnRd1 thioredoxin reductase-1 VEGF vascular endothelial growth factor XIAP X-linked inhibitor of apoptosis protein DeltaPsim mitochondrial membrane potential.	Sirolimus	957-966	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	282-287
31648572-7	2020	Abbreviations AKT protein kinase B ARMS alveolar rhabdomyosarcoma ATM ataxia telangiectasia mutated Bax Bcl-2-associated X protein Bcl-2 B-cell lymphoma 2 CDC2 cyclin-dependent kinase 2 Bcl-xL B-cell lymphoma-extra large c-FLIP cellular FLICE-like inhibitory protein CDDP cisplatin COX-2 cyclooxygenase-2 cyt c cytochrome c DNA-PKcs DNA-dependent protein kinase EGFR epidermal growth factor receptor EMT epithelial-mesenchymal transition ERK extracellular signal-regulated kinase ES Ewing`s sarcoma ETS2 erythroblastosis virus transcription factor 2 GBM glioblastoma multiforme HCC hepatocellular carcinoma HNSCC head and neck squamous cell carcinoma IAP inhibitor of apoptosis protein IkappaBalpha inhibitor of kappaB alpha IKK inhibitor of kappaB kinase IR ionizing radiation lncRNA long non-coding RNA luc luciferase Mcl-1 myeloid cell leukemia-1 MDR1 multidrug resistance protein 1 miR microRNA MMP-9 matrix metalloproteinase-9 mTOR mammalian target of rapamycin NB neuroblastoma NF-kappaB nuclear factor-kappaB NPC nasopharyngeal carcinoma NSCLC non-small cell lung cancer OSCC oral squamous cell carcinoma PARP poly-(ADP-ribose)-polymerase pH2AX phosphorylated histone 2AX-immunoreactive PI3K phosphatidylinositol 3-kinase Prp4K Pre-mRNA processing factor 4 kinase RCC renal cell carcinoma ROS reactive oxygen species SCC squamous cell carcinoma SLN solid lipid nanoparticle SOD2 superoxide dismutase 2 TERT telomerase reverse transcriptase TNF-alpha tumor necrosis factor-alpha TxnRd1 thioredoxin reductase-1 VEGF vascular endothelial growth factor XIAP X-linked inhibitor of apoptosis protein DeltaPsim mitochondrial membrane potential.	Poly Adenosine Diphosphate Ribose	1117-1134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	282-287
31648572-7	2020	Abbreviations AKT protein kinase B ARMS alveolar rhabdomyosarcoma ATM ataxia telangiectasia mutated Bax Bcl-2-associated X protein Bcl-2 B-cell lymphoma 2 CDC2 cyclin-dependent kinase 2 Bcl-xL B-cell lymphoma-extra large c-FLIP cellular FLICE-like inhibitory protein CDDP cisplatin COX-2 cyclooxygenase-2 cyt c cytochrome c DNA-PKcs DNA-dependent protein kinase EGFR epidermal growth factor receptor EMT epithelial-mesenchymal transition ERK extracellular signal-regulated kinase ES Ewing`s sarcoma ETS2 erythroblastosis virus transcription factor 2 GBM glioblastoma multiforme HCC hepatocellular carcinoma HNSCC head and neck squamous cell carcinoma IAP inhibitor of apoptosis protein IkappaBalpha inhibitor of kappaB alpha IKK inhibitor of kappaB kinase IR ionizing radiation lncRNA long non-coding RNA luc luciferase Mcl-1 myeloid cell leukemia-1 MDR1 multidrug resistance protein 1 miR microRNA MMP-9 matrix metalloproteinase-9 mTOR mammalian target of rapamycin NB neuroblastoma NF-kappaB nuclear factor-kappaB NPC nasopharyngeal carcinoma NSCLC non-small cell lung cancer OSCC oral squamous cell carcinoma PARP poly-(ADP-ribose)-polymerase pH2AX phosphorylated histone 2AX-immunoreactive PI3K phosphatidylinositol 3-kinase Prp4K Pre-mRNA processing factor 4 kinase RCC renal cell carcinoma ROS reactive oxygen species SCC squamous cell carcinoma SLN solid lipid nanoparticle SOD2 superoxide dismutase 2 TERT telomerase reverse transcriptase TNF-alpha tumor necrosis factor-alpha TxnRd1 thioredoxin reductase-1 VEGF vascular endothelial growth factor XIAP X-linked inhibitor of apoptosis protein DeltaPsim mitochondrial membrane potential.	Phosphatidylinositols	1199-1219	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	282-287
31648572-7	2020	Abbreviations AKT protein kinase B ARMS alveolar rhabdomyosarcoma ATM ataxia telangiectasia mutated Bax Bcl-2-associated X protein Bcl-2 B-cell lymphoma 2 CDC2 cyclin-dependent kinase 2 Bcl-xL B-cell lymphoma-extra large c-FLIP cellular FLICE-like inhibitory protein CDDP cisplatin COX-2 cyclooxygenase-2 cyt c cytochrome c DNA-PKcs DNA-dependent protein kinase EGFR epidermal growth factor receptor EMT epithelial-mesenchymal transition ERK extracellular signal-regulated kinase ES Ewing`s sarcoma ETS2 erythroblastosis virus transcription factor 2 GBM glioblastoma multiforme HCC hepatocellular carcinoma HNSCC head and neck squamous cell carcinoma IAP inhibitor of apoptosis protein IkappaBalpha inhibitor of kappaB alpha IKK inhibitor of kappaB kinase IR ionizing radiation lncRNA long non-coding RNA luc luciferase Mcl-1 myeloid cell leukemia-1 MDR1 multidrug resistance protein 1 miR microRNA MMP-9 matrix metalloproteinase-9 mTOR mammalian target of rapamycin NB neuroblastoma NF-kappaB nuclear factor-kappaB NPC nasopharyngeal carcinoma NSCLC non-small cell lung cancer OSCC oral squamous cell carcinoma PARP poly-(ADP-ribose)-polymerase pH2AX phosphorylated histone 2AX-immunoreactive PI3K phosphatidylinositol 3-kinase Prp4K Pre-mRNA processing factor 4 kinase RCC renal cell carcinoma ROS reactive oxygen species SCC squamous cell carcinoma SLN solid lipid nanoparticle SOD2 superoxide dismutase 2 TERT telomerase reverse transcriptase TNF-alpha tumor necrosis factor-alpha TxnRd1 thioredoxin reductase-1 VEGF vascular endothelial growth factor XIAP X-linked inhibitor of apoptosis protein DeltaPsim mitochondrial membrane potential.	Oxygen	293-299	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	282-287
31648572-7	2020	Abbreviations AKT protein kinase B ARMS alveolar rhabdomyosarcoma ATM ataxia telangiectasia mutated Bax Bcl-2-associated X protein Bcl-2 B-cell lymphoma 2 CDC2 cyclin-dependent kinase 2 Bcl-xL B-cell lymphoma-extra large c-FLIP cellular FLICE-like inhibitory protein CDDP cisplatin COX-2 cyclooxygenase-2 cyt c cytochrome c DNA-PKcs DNA-dependent protein kinase EGFR epidermal growth factor receptor EMT epithelial-mesenchymal transition ERK extracellular signal-regulated kinase ES Ewing`s sarcoma ETS2 erythroblastosis virus transcription factor 2 GBM glioblastoma multiforme HCC hepatocellular carcinoma HNSCC head and neck squamous cell carcinoma IAP inhibitor of apoptosis protein IkappaBalpha inhibitor of kappaB alpha IKK inhibitor of kappaB kinase IR ionizing radiation lncRNA long non-coding RNA luc luciferase Mcl-1 myeloid cell leukemia-1 MDR1 multidrug resistance protein 1 miR microRNA MMP-9 matrix metalloproteinase-9 mTOR mammalian target of rapamycin NB neuroblastoma NF-kappaB nuclear factor-kappaB NPC nasopharyngeal carcinoma NSCLC non-small cell lung cancer OSCC oral squamous cell carcinoma PARP poly-(ADP-ribose)-polymerase pH2AX phosphorylated histone 2AX-immunoreactive PI3K phosphatidylinositol 3-kinase Prp4K Pre-mRNA processing factor 4 kinase RCC renal cell carcinoma ROS reactive oxygen species SCC squamous cell carcinoma SLN solid lipid nanoparticle SOD2 superoxide dismutase 2 TERT telomerase reverse transcriptase TNF-alpha tumor necrosis factor-alpha TxnRd1 thioredoxin reductase-1 VEGF vascular endothelial growth factor XIAP X-linked inhibitor of apoptosis protein DeltaPsim mitochondrial membrane potential.	Superoxides	1386-1396	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	282-287
31655649-4	2019	Three HMIs, including Cu(II), Co(II) and Hg(II), were selected as studied ions and reacted with chelating agent sodium diethyldithiocarbamatetrihydrate to form metallic coordination compounds.	Sodium	112-151	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-36
31921815-11	2019	Finally, a selective COX-2 inhibitor commonly prescribed drug for OA, Celecoxib, was shown to downregulate the expression of catabolic and proinflammatory cytokines in the OA model, demonstrating the utility of the OC tissue chip model for drug screening.	celecoxib	70-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-26
31287731-5	2020	Results: Obesity increased the expression of proliferative signaling including COX-2, IL-6, AKT, ERK, and AR, which was attenuated with silibinin.	Silybin	136-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-84
31783472-0	2020	Selective adsorption of Co(II)/Mn(II) by zeolites from purified terephthalic acid wastewater containing dissolved aromatic organic compounds and metal ions.	Zeolites	41-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-30
31783472-0	2020	Selective adsorption of Co(II)/Mn(II) by zeolites from purified terephthalic acid wastewater containing dissolved aromatic organic compounds and metal ions.	terephthalic acid	64-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-30
31783472-1	2020	Selective separation and recovery of Co(II)/Mn(II) from purified terephthalic acid (PTA) production wastewater is very important to reduce the Co(II)/Mn(II) catalysts consumption and control the pollutant discharge.	Manganese	44-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-43
31783472-1	2020	Selective separation and recovery of Co(II)/Mn(II) from purified terephthalic acid (PTA) production wastewater is very important to reduce the Co(II)/Mn(II) catalysts consumption and control the pollutant discharge.	Manganese	44-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	143-149
31783472-1	2020	Selective separation and recovery of Co(II)/Mn(II) from purified terephthalic acid (PTA) production wastewater is very important to reduce the Co(II)/Mn(II) catalysts consumption and control the pollutant discharge.	terephthalic acid	65-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-43
31783472-1	2020	Selective separation and recovery of Co(II)/Mn(II) from purified terephthalic acid (PTA) production wastewater is very important to reduce the Co(II)/Mn(II) catalysts consumption and control the pollutant discharge.	terephthalic acid	65-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	143-149
31783472-1	2020	Selective separation and recovery of Co(II)/Mn(II) from purified terephthalic acid (PTA) production wastewater is very important to reduce the Co(II)/Mn(II) catalysts consumption and control the pollutant discharge.	Manganese	150-156	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-43
31783472-2	2020	This work employed zeolites NaA, NaX, and HZSM-5 with different pore sizes and Na(I) contents to selectively separate and recover Co(II)/Mn(II) from PTA wastewater and to understand the adsorption mechanism.	Zeolites	19-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	130-136
31783472-2	2020	This work employed zeolites NaA, NaX, and HZSM-5 with different pore sizes and Na(I) contents to selectively separate and recover Co(II)/Mn(II) from PTA wastewater and to understand the adsorption mechanism.	Sodium	28-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	130-136
31783472-2	2020	This work employed zeolites NaA, NaX, and HZSM-5 with different pore sizes and Na(I) contents to selectively separate and recover Co(II)/Mn(II) from PTA wastewater and to understand the adsorption mechanism.	Sodium	33-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	130-136
31783472-3	2020	It is found that only NaA can exclusively adsorb Co(II)/Mn(II) through ion-exchange without adsorbing any aromatic organic compound (AOC); oppositely, HZSM-5 shows the highest adsorption capacity for AOCs but almost no adsorption for Co(II)/Mn(II); and NaX exhibits moderate adsorption capacities for both Co(II)/Mn(II) and AOCs.	Sodium	22-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-55
31783472-3	2020	It is found that only NaA can exclusively adsorb Co(II)/Mn(II) through ion-exchange without adsorbing any aromatic organic compound (AOC); oppositely, HZSM-5 shows the highest adsorption capacity for AOCs but almost no adsorption for Co(II)/Mn(II); and NaX exhibits moderate adsorption capacities for both Co(II)/Mn(II) and AOCs.	Sodium	22-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	234-240
31783472-3	2020	It is found that only NaA can exclusively adsorb Co(II)/Mn(II) through ion-exchange without adsorbing any aromatic organic compound (AOC); oppositely, HZSM-5 shows the highest adsorption capacity for AOCs but almost no adsorption for Co(II)/Mn(II); and NaX exhibits moderate adsorption capacities for both Co(II)/Mn(II) and AOCs.	Sodium	22-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	234-240
31783472-4	2020	Moreover, pH can significantly impact the adsorption of both Co(II)/Mn(II) and AOCs due to the competitive adsorption between H(I) and Co(II)/Mn(II) and the electrostatic repulsion between AOCs and zeolites.	Manganese	68-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-67
31783472-4	2020	Moreover, pH can significantly impact the adsorption of both Co(II)/Mn(II) and AOCs due to the competitive adsorption between H(I) and Co(II)/Mn(II) and the electrostatic repulsion between AOCs and zeolites.	Manganese	68-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-141
31783472-4	2020	Moreover, pH can significantly impact the adsorption of both Co(II)/Mn(II) and AOCs due to the competitive adsorption between H(I) and Co(II)/Mn(II) and the electrostatic repulsion between AOCs and zeolites.	Hydrogen	126-130	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-67
31783472-4	2020	Moreover, pH can significantly impact the adsorption of both Co(II)/Mn(II) and AOCs due to the competitive adsorption between H(I) and Co(II)/Mn(II) and the electrostatic repulsion between AOCs and zeolites.	Manganese	142-148	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-67
31783472-4	2020	Moreover, pH can significantly impact the adsorption of both Co(II)/Mn(II) and AOCs due to the competitive adsorption between H(I) and Co(II)/Mn(II) and the electrostatic repulsion between AOCs and zeolites.	Zeolites	198-206	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-67
31783472-6	2020	Importantly, bench-scale experiments for simulating the industrial operation were carried out, and the results show that the adsorption capacity of the NaA particles for Co(II)/Mn(II) from the industrial PTA wastewater is 9.1/8.6 mg/g, respectively, without adsorbing any AOC.	Sodium	152-155	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	170-176
31783472-6	2020	Importantly, bench-scale experiments for simulating the industrial operation were carried out, and the results show that the adsorption capacity of the NaA particles for Co(II)/Mn(II) from the industrial PTA wastewater is 9.1/8.6 mg/g, respectively, without adsorbing any AOC.	Manganese	177-183	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	170-176
31636070-7	2019	Moreover, compound 2d significantly inhibited COX-2 enzymatic activities and prostaglandin E2 levels, associated with viral replication, compared to results with a selective COX-2 inhibitor, celecoxib.	Echothiophate Iodide	19-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
31636070-7	2019	Moreover, compound 2d significantly inhibited COX-2 enzymatic activities and prostaglandin E2 levels, associated with viral replication, compared to results with a selective COX-2 inhibitor, celecoxib.	Echothiophate Iodide	19-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	174-179
31851937-4	2019	Accordingly, we demonstrate that COA6 can reduce the copper-coordinating disulfides of its client proteins, SCO1 and COX2, allowing for copper binding.	Disulfides	73-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-121
31851937-3	2019	To uncover the molecular mechanism by which COA6 and SCO proteins mediate copper delivery to COX2, we have solved the solution structure of COA6, which reveals a coiled-coil-helix-coiled-coil-helix domain typical of redox-active proteins found in the mitochondrial inter-membrane space.	Copper	74-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-97
31851937-4	2019	Accordingly, we demonstrate that COA6 can reduce the copper-coordinating disulfides of its client proteins, SCO1 and COX2, allowing for copper binding.	Copper	136-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-121
31851937-4	2019	Accordingly, we demonstrate that COA6 can reduce the copper-coordinating disulfides of its client proteins, SCO1 and COX2, allowing for copper binding.	Copper	53-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-121
31774277-0	2019	Stereochemistry of Hexacoordinated Zn(II), Cu(II), Ni(II), and Co(II) Complexes with Iminodiacetamide Ligands.	iminodiacetamide	85-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-69
31794201-1	2019	Utilizing the oxygen-bridged 5,5"-oxidiisophthalic acid (H4L) linker, one Co(II)-based 3D porous MOF {[Co5(L)2(OH)2(OH2)2(H2O)4] 2DMF H2O}n (1) with pentanuclear [Co5(mu3-OH)2(mu2-OH2)2]8+ cluster was prepared.	Oxygen	14-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
31774277-1	2019	Metal complexes of iminodiacetamide (imda) ligands and metal ions Zn(II), Cu(II), Ni(II), and Co(II) were prepared using eight imda ligands (L1-L8) substituted with groups of different steric and electronic properties on the central amine N atom (H atom, methyl, isopropyl, and benzyl) and the para position of the phenyl rings (nitro and dimethylamino).	iminodiacetamide	19-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-100
31794201-1	2019	Utilizing the oxygen-bridged 5,5"-oxidiisophthalic acid (H4L) linker, one Co(II)-based 3D porous MOF {[Co5(L)2(OH)2(OH2)2(H2O)4] 2DMF H2O}n (1) with pentanuclear [Co5(mu3-OH)2(mu2-OH2)2]8+ cluster was prepared.	gastrofenzin	29-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
31774277-1	2019	Metal complexes of iminodiacetamide (imda) ligands and metal ions Zn(II), Cu(II), Ni(II), and Co(II) were prepared using eight imda ligands (L1-L8) substituted with groups of different steric and electronic properties on the central amine N atom (H atom, methyl, isopropyl, and benzyl) and the para position of the phenyl rings (nitro and dimethylamino).	iminodiacetic acid	127-131	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-100
31794201-1	2019	Utilizing the oxygen-bridged 5,5"-oxidiisophthalic acid (H4L) linker, one Co(II)-based 3D porous MOF {[Co5(L)2(OH)2(OH2)2(H2O)4] 2DMF H2O}n (1) with pentanuclear [Co5(mu3-OH)2(mu2-OH2)2]8+ cluster was prepared.	Hydrogen	57-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
31794201-1	2019	Utilizing the oxygen-bridged 5,5"-oxidiisophthalic acid (H4L) linker, one Co(II)-based 3D porous MOF {[Co5(L)2(OH)2(OH2)2(H2O)4] 2DMF H2O}n (1) with pentanuclear [Co5(mu3-OH)2(mu2-OH2)2]8+ cluster was prepared.	hydroxide ion	162-188	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
31774665-2	2019	Herein, we report a calix[4]resorcinarene-based [Co12] coordination cage, [Co12(TPC4R-I)2(1,3-BDC)10(mu3-OH)4(H2O)10(DMF)2] 7DMF 23H2O (1), assembled with 2 bowl-shaped calix[4]resorcinarenes (TPC4R-I), 10 angular 1,3-benzenedicarboxylates (1,3-BDC), and 12 Co(II) cations.	resorcinarene	20-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	258-264
31774665-2	2019	Herein, we report a calix[4]resorcinarene-based [Co12] coordination cage, [Co12(TPC4R-I)2(1,3-BDC)10(mu3-OH)4(H2O)10(DMF)2] 7DMF 23H2O (1), assembled with 2 bowl-shaped calix[4]resorcinarenes (TPC4R-I), 10 angular 1,3-benzenedicarboxylates (1,3-BDC), and 12 Co(II) cations.	AN 12	49-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	258-264
31774665-2	2019	Herein, we report a calix[4]resorcinarene-based [Co12] coordination cage, [Co12(TPC4R-I)2(1,3-BDC)10(mu3-OH)4(H2O)10(DMF)2] 7DMF 23H2O (1), assembled with 2 bowl-shaped calix[4]resorcinarenes (TPC4R-I), 10 angular 1,3-benzenedicarboxylates (1,3-BDC), and 12 Co(II) cations.	N-hydroxymethyl-N-methylformamide	74-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	258-264
31774665-3	2019	Remarkably, it is shown to be a highly efficient recyclable heterogeneous catalyst for CO2 conversion due to its exposed Co(II) Lewis acid sites.	Carbon Dioxide	87-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-126
31847496-4	2019	COX-2 expression in HepG2/PTX cells was significantly suppressed by PTX-TSL-siCOX-2(9R/DG-GNS) in high temperatures.	ptx	26-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
31847496-4	2019	COX-2 expression in HepG2/PTX cells was significantly suppressed by PTX-TSL-siCOX-2(9R/DG-GNS) in high temperatures.	ptx	68-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
31835645-0	2019	Ellagic Acid Inhibits Extracellular Acidity-Induced Invasiveness and Expression of COX1, COX2, Snail, Twist 1, and c-myc in Gastric Carcinoma Cells.	Ellagic Acid	0-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-93
31697295-1	2019	A series of thiocyanato-bridged heterometallic coordination polymers with a 3D reticular network have been synthesised by the reaction of [PtIV(SCN)6]2- with MII ions to form {MII[PtIV(SCN)6]}n and {[MII(CH3OH)2][PtIV(SCN)6]}n (MII = MnII, FeII, CoII, NiII or CuII) in water and methanol, respectively.	6-thiocyanatoriboflavin	12-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	246-250
31697295-3	2019	One of the two coordinating methanol molecules in {[CoII(CH3OH)2][PtIV(SCN)6]}n was replaced with pyridine to stabilise the open metal sites, because the methanol molecules are too labile to maintain open metal sites in water.	Methanol	28-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-56
31697295-3	2019	One of the two coordinating methanol molecules in {[CoII(CH3OH)2][PtIV(SCN)6]}n was replaced with pyridine to stabilise the open metal sites, because the methanol molecules are too labile to maintain open metal sites in water.	Methanol	154-162	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-56
31817839-8	2019	In summary, we show here that the pro-angiogenic effect of NGF in EOC depends on the COX-2/PGE2 signaling axis.	Dinoprostone	91-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-90
31811113-4	2019	RESULTS Cells predisposed to MG demonstrated an increase in oxidative stress with augmented (P&lt;0.01) inflammatory cytokines such as cyclooxygenase (COX)-2, chemokine receptor CXCR4, interleukin (IL)-6, IL-8, monocyte chemoattractant protein-1 (MCP-1), and intercellular adhesion molecule 1 (ICAM-1) genes.	Pyruvaldehyde	29-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-157
31817839-0	2019	NGF-Enhanced Vasculogenic Properties of Epithelial Ovarian Cancer Cells Is Reduced by Inhibition of the COX-2/PGE2 Signaling Axis.	Dinoprostone	110-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
31867480-1	2019	The solvent-induced topological and structural diversities of two Co(II) complexes, namely, [Co(L)2(SCN)2] (Co1) and [Co2(L)2(SCN)(OAc)3] (Co2) (L = 8-methoxyquinoline), were comparatively analyzed.	cobalt(II) tetrathiocyanate	92-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-72
31867480-1	2019	The solvent-induced topological and structural diversities of two Co(II) complexes, namely, [Co(L)2(SCN)2] (Co1) and [Co2(L)2(SCN)(OAc)3] (Co2) (L = 8-methoxyquinoline), were comparatively analyzed.	6-methoxyquinoline	149-167	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-72
31867480-4	2019	The Co(II) ion in complex Co1 was coordinated by the N4O2 mode provided by two L ligands and two SCN- anions.	Superoxides	53-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
31867480-5	2019	The two Co(II) ions in Co2 were in the N2O4 and NO5 coordination environment and were linked by two mu2-OAc- bridges and one rare mu3-OAc- bridge.	Superoxides	39-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	8-14
31867480-5	2019	The two Co(II) ions in Co2 were in the N2O4 and NO5 coordination environment and were linked by two mu2-OAc- bridges and one rare mu3-OAc- bridge.	gastrofenzin	48-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	8-14
31867480-5	2019	The two Co(II) ions in Co2 were in the N2O4 and NO5 coordination environment and were linked by two mu2-OAc- bridges and one rare mu3-OAc- bridge.	SDZ 33-243	104-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	8-14
31867480-5	2019	The two Co(II) ions in Co2 were in the N2O4 and NO5 coordination environment and were linked by two mu2-OAc- bridges and one rare mu3-OAc- bridge.	SDZ 33-243	134-137	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	8-14
31725272-3	2019	The crystal structure of Co(II)-TMU-63 is assembled from two types of organic building blocks (mu4-tpa2- and mu-dapz ligands), which arrange the cobalt nodes into a complex layer-pillared net with an unreported 4,4,4,6T14 topology.	Cobalt	145-151	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-38
31725272-7	2019	Also, the Co(II)-TMU-63//activated carbon (AC) asymmetric supercapacitor acted in a broad potential window of 1.7 V (0-1.7 V), exhibiting a high performance with 4.42 kW kg-1 power density (PD) and 24.13 Whkg-1 energy density (ED).	Carbon	35-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-23
31725272-1	2019	In this work, a new 3D metal-organic framework (MOF) {[Co3(mu4-tpa)3(mu-dapz)(DMF)2] 2DMF}n (Co(II)-TMU-63; H2tpa = terephthalic acid, dapz = pyrazine-2,5-diamine, DMF = dimethylformamide) containing low-cost and readily available ligands was generated, fully characterized, and used as an electrode material in supercapacitors without the need for a calcination process.	3'-dimethylaminoflavone	54-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-106
31586705-6	2019	The results of this study indicate that the new derivatives of OAO and particularly their conjugates with ASP, downregulate the expression of COX-2 in HepG2 cells by modulating the NF-kappaB signaling pathway and suggest their potential application in the prevention of liver inflammation and cancer.	Oximes	63-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	142-147
31586705-6	2019	The results of this study indicate that the new derivatives of OAO and particularly their conjugates with ASP, downregulate the expression of COX-2 in HepG2 cells by modulating the NF-kappaB signaling pathway and suggest their potential application in the prevention of liver inflammation and cancer.	Aspirin	106-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	142-147
31680333-0	2019	Co(II)-salen catalyzed stereoselective cyclopropanation of fluorinated styrenes.	Styrene	71-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
31680333-1	2019	Three cis-selective Co(II)-salen complexes have been developed for the asymmetric cyclopropanation of para-fluorinated styrenes with ethyl diazoacetate.	Styrene	119-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-26
31680333-1	2019	Three cis-selective Co(II)-salen complexes have been developed for the asymmetric cyclopropanation of para-fluorinated styrenes with ethyl diazoacetate.	diazoacetic ester	133-151	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-26
31610507-7	2019	The abundant unsaturated metal active sites of Fe(II) and Co(II) in the skeleton of FeCo-BDC made a great contribution to the generation of sulfate () and hydroxyl radicals (OH), which resulted in the excellent performance for MB degradation.	Iron	84-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-64
31610507-7	2019	The abundant unsaturated metal active sites of Fe(II) and Co(II) in the skeleton of FeCo-BDC made a great contribution to the generation of sulfate () and hydroxyl radicals (OH), which resulted in the excellent performance for MB degradation.	Sulfates	140-147	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-64
31610507-7	2019	The abundant unsaturated metal active sites of Fe(II) and Co(II) in the skeleton of FeCo-BDC made a great contribution to the generation of sulfate () and hydroxyl radicals (OH), which resulted in the excellent performance for MB degradation.	Hydroxyl Radical	155-163	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-64
31123968-8	2019	Summarizing, cotreatment with cilostazol and celecoxib exhibited a synergistic increase in IL-10 production and SOCS3 expressions, thereby resulted in synergistic decreases in IL-1beta mRNA, IL-6 mRNA expression and TNF-alpha synthesis in association with synergistic decreases in COX-2 and PGE2 protein expression in the RA synovial fibroblasts.	Cilostazol	30-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	281-286
31539778-0	2019	New oxadiazoles with selective-COX-2 and EGFR dual inhibitory activity: Design, synthesis, cytotoxicity evaluation and in silico studies.	Oxadiazoles	4-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-36
31123968-8	2019	Summarizing, cotreatment with cilostazol and celecoxib exhibited a synergistic increase in IL-10 production and SOCS3 expressions, thereby resulted in synergistic decreases in IL-1beta mRNA, IL-6 mRNA expression and TNF-alpha synthesis in association with synergistic decreases in COX-2 and PGE2 protein expression in the RA synovial fibroblasts.	Celecoxib	45-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	281-286
31218676-0	2019	Immunohistochemical evaluation of the effect of acitretin and systemic steroid treatments on Ki-67, Bcl-2, and COX-2 levels in cutaneous lichen planus patients.	Steroids	71-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	111-116
31218676-6	2019	OBJECTIVE: The purpose of this study was to investigate the effects of prednisolone and acitretin treatments on Ki-67, Bcl-2, and COX-2 expression and apoptosis in patients with LP and the role of Ki-67, Bcl-2, and COX-2 proteins in LP.	Prednisolone	71-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	130-135
31218676-6	2019	OBJECTIVE: The purpose of this study was to investigate the effects of prednisolone and acitretin treatments on Ki-67, Bcl-2, and COX-2 expression and apoptosis in patients with LP and the role of Ki-67, Bcl-2, and COX-2 proteins in LP.	Acitretin	88-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	130-135
31218676-6	2019	OBJECTIVE: The purpose of this study was to investigate the effects of prednisolone and acitretin treatments on Ki-67, Bcl-2, and COX-2 expression and apoptosis in patients with LP and the role of Ki-67, Bcl-2, and COX-2 proteins in LP.	Acitretin	88-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	215-220
31641036-0	2019	Epoxyeicosatrienoic acid (EET)-stimulated angiogenesis is mediated by epoxy hydroxyeicosatrienoic acids (EHETs) formed from COX-2.	5,6-epoxy-8,11,14-eicosatrienoic acid	0-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	124-129
31641036-0	2019	Epoxyeicosatrienoic acid (EET)-stimulated angiogenesis is mediated by epoxy hydroxyeicosatrienoic acids (EHETs) formed from COX-2.	5,6-epoxy-8,11,14-eicosatrienoic acid	26-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	124-129
31641036-0	2019	Epoxyeicosatrienoic acid (EET)-stimulated angiogenesis is mediated by epoxy hydroxyeicosatrienoic acids (EHETs) formed from COX-2.	15-hydroxyeicosatrienoic acid	70-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	124-129
31641036-0	2019	Epoxyeicosatrienoic acid (EET)-stimulated angiogenesis is mediated by epoxy hydroxyeicosatrienoic acids (EHETs) formed from COX-2.	15-hydroxyeicosatrienoic acid	105-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	124-129
31641036-2	2019	EETs elicit endothelial angiogenic activity linked to tumor growth in various cancer models that can be attenuated in vivo by COX-2 inhibitors.	5,6-epoxy-8,11,14-eicosatrienoic acid	0-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-131
31641036-3	2019	This study further defines the relationship between endothelial EET metabolism and COX-2 in promoting angiogenesis.	5,6-epoxy-8,11,14-eicosatrienoic acid	64-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
31641036-6	2019	Contributing to this response were 8,9-EET metabolites formed from COX-2, the 11-hydroxy-8,9-EET (8,9,11-EHET) and 15-hydroxy-8,9-EET (8,9,15-EHET).	5,6-epoxy-8,11,14-eicosatrienoic acid	39-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-72
31641036-6	2019	Contributing to this response were 8,9-EET metabolites formed from COX-2, the 11-hydroxy-8,9-EET (8,9,11-EHET) and 15-hydroxy-8,9-EET (8,9,15-EHET).	galanin (1-15), Thr(6)-Trp(8,9)-15-ol	135-146	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-72
31641036-9	2019	These results indicate that 8,9-EET-stimulated angiogenesis is enhanced by COX-2 metabolism in endothelium through formation of 8,9,11-EHET.	5,6-epoxy-8,11,14-eicosatrienoic acid	32-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
31425733-4	2019	We found that epinephrine and norepinephrine up-regulate COX2 expression and PGD2 production through beta1-and beta2-ADRs.	Epinephrine	14-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-61
31425733-4	2019	We found that epinephrine and norepinephrine up-regulate COX2 expression and PGD2 production through beta1-and beta2-ADRs.	Norepinephrine	30-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-61
31562254-5	2019	We further show that the enhanced activity of the IL1beta/COX-2/MCP-1 axis and a resulting increase in PGE2 production by adipocytes coincide with augmented hypoxia signaling and activation of prosurvival pathways in tumor cells, revealing a potential mechanism of chemoresistance.	Dinoprostone	103-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
31002851-10	2019	PBM can significantly enhance expression of osteocalcin, collagen, RUNX-2, vascular endothelial growth factor, bone morphogenic proteins, and COX-2.	pbm	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	142-147
31885820-9	2019	Moreover, alpha-LA has mechanisms of epigenetic regulation in genes related to the expression of various inflammatory mediators, such PGE2, COX-2, iNOS, TNF-alpha, IL-1beta, and IL-6.	Thioctic Acid	10-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-145
31622088-2	2019	In addition to C-H bonds with varied electronic properties, the Co(II)-based metalloradical system features chemoselective amination of allylic C-H bonds and is compatible with heteroaryl groups, producing functionalized 5-membered chiral cyclic sulfonamides in high yields with high enantioselectivities.	Hydrogen	15-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-69
31123968-1	2019	Cilostazol (an inhibitor of phosphodiesterase type III) has potent anti-inflammatory effects, and celecoxib (a COX-2 specific inhibitor) has been reported to improve the unsatisfactory profile of NSAIDs.	Celecoxib	98-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	111-116
31123968-3	2019	Increased COX-2 protein expression and PGE2 synthesis by LPS (1 mug/ml) were significantly and synergistically attenuated by cotreatment with 3 muM cilostazol and 30 muM celecoxib, whereas monotherapy with either cilostazol or celecoxib showed little effects.	Cilostazol	148-158	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
31123968-3	2019	Increased COX-2 protein expression and PGE2 synthesis by LPS (1 mug/ml) were significantly and synergistically attenuated by cotreatment with 3 muM cilostazol and 30 muM celecoxib, whereas monotherapy with either cilostazol or celecoxib showed little effects.	Celecoxib	170-179	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
31123968-3	2019	Increased COX-2 protein expression and PGE2 synthesis by LPS (1 mug/ml) were significantly and synergistically attenuated by cotreatment with 3 muM cilostazol and 30 muM celecoxib, whereas monotherapy with either cilostazol or celecoxib showed little effects.	Cilostazol	213-223	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
31123968-3	2019	Increased COX-2 protein expression and PGE2 synthesis by LPS (1 mug/ml) were significantly and synergistically attenuated by cotreatment with 3 muM cilostazol and 30 muM celecoxib, whereas monotherapy with either cilostazol or celecoxib showed little effects.	Celecoxib	227-236	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
31264803-3	2019	The paramagnetic nature of all the solids was evidenced by magnetic susceptibility measurements, showing the variation of the oxidation states of two cobalt centers in [1L -nmc ]n+ from CoII 1.00 CoIII 1.00 for X=ClO4 - or NO3 - to CoII 0.67 CoIII 1.33 for X=Cl- , via CoII 0.83 CoIII 1.17 for X=SO4 2- .	Cobalt	150-156	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	186-190
31835645-5	2019	Examining regulatory factors contributing to the acidity-mediated invasiveness, we found that an acidic pH increased the expression of COX1 and COX2; importantly, expression decreased under the ellagic acid treatment.	Ellagic Acid	194-206	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	144-148
31835645-8	2019	Together, these results suggest that ellagic acid suppresses acidity-enhanced migration and invasion of gastric cancer cells via inhibition of the expression of multiple factors (COX1, COX2, snail, twist1, and c-myc); for this reason, it may be an effective agent for cancer treatment under acidosis.	Ellagic Acid	37-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	185-189
31849641-2	2019	Bioactivity-guided fractionation using expression of PTGS2 (COX-2) mRNA as a readout resulted in the isolation of two C13 megastigmane glycosides, gusanlungionoside C (1) and citroside A (3), and the phenylalcohol glycoside phenylmethyl-2-O-(6-O-rhamnosyl)-ss-D-galactopyranoside (2).	megastigmane	118-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-65
31849641-2	2019	Bioactivity-guided fractionation using expression of PTGS2 (COX-2) mRNA as a readout resulted in the isolation of two C13 megastigmane glycosides, gusanlungionoside C (1) and citroside A (3), and the phenylalcohol glycoside phenylmethyl-2-O-(6-O-rhamnosyl)-ss-D-galactopyranoside (2).	Carbon	147-166	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-65
31849641-2	2019	Bioactivity-guided fractionation using expression of PTGS2 (COX-2) mRNA as a readout resulted in the isolation of two C13 megastigmane glycosides, gusanlungionoside C (1) and citroside A (3), and the phenylalcohol glycoside phenylmethyl-2-O-(6-O-rhamnosyl)-ss-D-galactopyranoside (2).	citroside A	175-186	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-65
31849641-2	2019	Bioactivity-guided fractionation using expression of PTGS2 (COX-2) mRNA as a readout resulted in the isolation of two C13 megastigmane glycosides, gusanlungionoside C (1) and citroside A (3), and the phenylalcohol glycoside phenylmethyl-2-O-(6-O-rhamnosyl)-ss-D-galactopyranoside (2).	methoxypolyethylene glycol succinimidylsuccinate	200-279	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-65
31871896-14	2020	A high glucose level also induced upregulation of COX2 (p=0.046) in healthy TDSCs and tendinopathic TDSCs (p=0.050).	Glucose	7-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-54
31347667-10	2019	The increase in Snail and Cox2 expression with TGFbeta1was reproduced in human OSE cultures, suggesting these responses are conserved between mouse and human.	serine O-sulfate	79-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-30
31757048-7	2019	In parallel, the combination of ginkgetin and resveratrol synergistically relieved the 5-fluorouracil-induced inflammatory response by suppressing expressions of COX-2 and inflammatory cytokines.	ginkgetin	32-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	162-167
31757048-7	2019	In parallel, the combination of ginkgetin and resveratrol synergistically relieved the 5-fluorouracil-induced inflammatory response by suppressing expressions of COX-2 and inflammatory cytokines.	resveratrol	46-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	162-167
31757048-7	2019	In parallel, the combination of ginkgetin and resveratrol synergistically relieved the 5-fluorouracil-induced inflammatory response by suppressing expressions of COX-2 and inflammatory cytokines.	Fluorouracil	87-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	162-167
31616883-0	2019	Mechanistic insights into the non-bifunctional hydrogenation of esters by Co(ii) pincer complexes: a DFT study.	Esters	64-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-80
31617517-0	2019	Fluorination as tool to improve bioanalytical sensitivity and COX-2-selective antitumor activity of cobalt alkyne complexes.	cobalt alkyne	100-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
31617517-1	2019	The cobalt alkyne complex [(prop-2-ynyl)-2-acetoxybenzoate]dicobalthexacarbonyl (Co-ASS) is an auspicious lead, which exhibits its anticancer activity mainly by inhibition of both cyclooxygenases (COX-1 and COX-2).	cobalt alkyne	4-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	207-212
31617517-1	2019	The cobalt alkyne complex [(prop-2-ynyl)-2-acetoxybenzoate]dicobalthexacarbonyl (Co-ASS) is an auspicious lead, which exhibits its anticancer activity mainly by inhibition of both cyclooxygenases (COX-1 and COX-2).	[(prop-2-ynyl)-2-acetoxybenzoate]dicobalthexacarbonyl	26-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	207-212
31617517-1	2019	The cobalt alkyne complex [(prop-2-ynyl)-2-acetoxybenzoate]dicobalthexacarbonyl (Co-ASS) is an auspicious lead, which exhibits its anticancer activity mainly by inhibition of both cyclooxygenases (COX-1 and COX-2).	co-ass	81-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	207-212
31622088-2	2019	In addition to C-H bonds with varied electronic properties, the Co(II)-based metalloradical system features chemoselective amination of allylic C-H bonds and is compatible with heteroaryl groups, producing functionalized 5-membered chiral cyclic sulfonamides in high yields with high enantioselectivities.	allyl alcohol	136-147	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-69
31622088-2	2019	In addition to C-H bonds with varied electronic properties, the Co(II)-based metalloradical system features chemoselective amination of allylic C-H bonds and is compatible with heteroaryl groups, producing functionalized 5-membered chiral cyclic sulfonamides in high yields with high enantioselectivities.	Sulfonamides	239-258	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-69
31622088-3	2019	The unique profile of reactivity and selectivity of the Co(II)-catalyzed C-H amination is attributed to its underlying stepwise radical mechanism, which is supported by several lines of experimental evidence.	Hydrogen	73-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-61
31468606-2	2019	The modified oligonucleotides were shown to complex a range of different transition metal cations including Ni(II), Cu(II), Zn(II) and Co(II), as indicated by UV/Vis spectroscopy and ion mobility mass spectrometry.	Oligonucleotides	13-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-141
31497810-0	2019	Water-mediated proton conduction in Ni(ii) and Co(ii) benzenetriphosphonates.	Water	0-5	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-41
31497810-0	2019	Water-mediated proton conduction in Ni(ii) and Co(ii) benzenetriphosphonates.	Water	0-5	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-53
31545553-0	2019	Entrapment of a Pseudo-Tetrahedral CoII Center by Thioether Sulfur Bound {Co2 (mu-L)} Fragments: Synthesis, Field-Induced Single-Ion Magnetism and Catechol Oxidase Mimicking Activity.	thioether sulfur	50-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-39
31545553-0	2019	Entrapment of a Pseudo-Tetrahedral CoII Center by Thioether Sulfur Bound {Co2 (mu-L)} Fragments: Synthesis, Field-Induced Single-Ion Magnetism and Catechol Oxidase Mimicking Activity.	Carbon Dioxide	74-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-39
31750287-3	2019	This central CoII ion is connected to four outer, octahedrally coordinated low-spin CoIII ions via oxo bridges.	N-methylacetamide-oxotremorine M	99-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-17
31750287-4	2019	Compound 2 comprises a semi-circular {  Co 4 II    Co 2 III   } motif of four non-interacting high-spin CoII and two low-spin CoIII centers in octahedral coordination environments.	12-(4'-azido-2'-nitrophenoxy)dodecanoyl-coenzyme A	40-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-108
31468606-2	2019	The modified oligonucleotides were shown to complex a range of different transition metal cations including Ni(II), Cu(II), Zn(II) and Co(II), as indicated by UV/Vis spectroscopy and ion mobility mass spectrometry.	Metals	84-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-141
31493708-6	2019	Among the series, compound 8i with electron withdrawing fluoro group at the para position of the benzoyl ring of benzophenone was characterized by highest IC50 values for both COX-1 and COX-2 inhibition, which is comparable to the standard drug.	benzophenone	113-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	186-191
31857834-1	2019	Here we first report the design of a series of bis-chelate Co(II) 5,7-dihalo-8-quinolinol-phenanthroline derivative complexes, [Co(py)(QL1)2] (Co1), [Co(py)(QL2)2] (Co2), [Co(Phen)(QL1)2] (Co3), [Co(Phen)(QL2)2] (Co4), [Co(DPQ)(QL1)2] (CH3OH)4 (Co5), [Co(DPQ)(QL2)2] (Co6), [Co(DPPZ)(QL1)2] CH3OH (Co7), [Co(MDP)(QL1)2] 3H2O (Co8), [Co(ODP)(QL1)2] CH3OH (Co9), [Co(PPT)(QL1)2] CH3OH (Co10), [Co(ClPT)(QL1)2] (Co11), [Co(dpy)(QL3)2] (Co12), [Co(mpy)(QL1)2] (Co13), [Co(Phen)(QL4)2] (Co14), [Co(ODP)(QL4)2] (Co15), [Co(mpy)(QL4)2]I (Co16), [Co(ClPT)(QL4)2] (Co17), and [Co(ClPT)(QL5)2] (Co18), with 5,7-dihalo-8-quinolinol and 2,2"-bipyridine mixed ligands.	nitro-bis(2,4-pentanedionato)(pyridine)cobalt(III)	128-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
31707149-9	2019	FINDINGS: COX2 and TBXAS are highly expressed in BE and EAC patients accompanied by a pronounced elevation of circulating TXA2 levels.	Thromboxane A2	122-126	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-14
31753071-1	2019	Proton reduction by [CoII(BPyPy2COH)(OH2)2]2+ (BPyPy2COH = [2,2"-bipyridin]-6-yl-di[pyridin-2-yl]methanol) proceeds through two distinct, pH-dependent pathways involving proton-coupled electron transfer (PCET), reduction and protonation steps.	1,3-bis(3,5-dichlorophenyl)urea	26-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-25
31753071-1	2019	Proton reduction by [CoII(BPyPy2COH)(OH2)2]2+ (BPyPy2COH = [2,2"-bipyridin]-6-yl-di[pyridin-2-yl]methanol) proceeds through two distinct, pH-dependent pathways involving proton-coupled electron transfer (PCET), reduction and protonation steps.	Methanol	59-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-25
31753071-5	2019	In our simulation, both CoI and CoII-H feature a strong interaction with the surrounding solvent via hydrogen bonding, which is expected to foster the following catalytic step.	Hydrogen	101-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-36
31479958-2	2019	Here we report that Cu(II)/H2O2/Cl- system is a unique "halotolerant" Fenton-like process that works most efficiently in saline water among the five tested redox-active metals ions (i.e. Cr(VI), Ce(III), Co(II), Mn(II) and Cu(II)).	cu(ii)	20-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	204-210
31479958-2	2019	Here we report that Cu(II)/H2O2/Cl- system is a unique "halotolerant" Fenton-like process that works most efficiently in saline water among the five tested redox-active metals ions (i.e. Cr(VI), Ce(III), Co(II), Mn(II) and Cu(II)).	Hydrogen Peroxide	27-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	204-210
31479958-2	2019	Here we report that Cu(II)/H2O2/Cl- system is a unique "halotolerant" Fenton-like process that works most efficiently in saline water among the five tested redox-active metals ions (i.e. Cr(VI), Ce(III), Co(II), Mn(II) and Cu(II)).	Sodium Chloride	121-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	204-210
31455615-3	2019	We developed an LC-HRMS based hCOX-2 screening assay to examine its ability to also convert n-3 PUFA-derived N-acylethanolamines.	Fatty Acids, Omega-3	92-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-36
31455615-3	2019	We developed an LC-HRMS based hCOX-2 screening assay to examine its ability to also convert n-3 PUFA-derived N-acylethanolamines.	derived	101-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-36
31455615-3	2019	We developed an LC-HRMS based hCOX-2 screening assay to examine its ability to also convert n-3 PUFA-derived N-acylethanolamines.	N-acylethanolamines	109-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-36
31455615-4	2019	Our assay yields known hCOX-2 derived products from established PUFAs and anandamide.	anandamide	74-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-29
31455615-6	2019	Interestingly, we demonstrated that docosahexaenoylethanolamide (DHEA) is converted by hCOX-2 into the previously unknown metabolites 13- and 16-hydroxy-docosahexaenoyl ethanolamide (13- and 16-HDHEA, respectively).	docosahexaenoylethanolamide	36-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-93
31455615-6	2019	Interestingly, we demonstrated that docosahexaenoylethanolamide (DHEA) is converted by hCOX-2 into the previously unknown metabolites 13- and 16-hydroxy-docosahexaenoyl ethanolamide (13- and 16-HDHEA, respectively).	Dehydroepiandrosterone	65-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-93
31455615-6	2019	Interestingly, we demonstrated that docosahexaenoylethanolamide (DHEA) is converted by hCOX-2 into the previously unknown metabolites 13- and 16-hydroxy-docosahexaenoyl ethanolamide (13- and 16-HDHEA, respectively).	13- and 16-hydroxy-docosahexaenoyl ethanolamide	134-181	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-93
31857834-1	2019	Here we first report the design of a series of bis-chelate Co(II) 5,7-dihalo-8-quinolinol-phenanthroline derivative complexes, [Co(py)(QL1)2] (Co1), [Co(py)(QL2)2] (Co2), [Co(Phen)(QL1)2] (Co3), [Co(Phen)(QL2)2] (Co4), [Co(DPQ)(QL1)2] (CH3OH)4 (Co5), [Co(DPQ)(QL2)2] (Co6), [Co(DPPZ)(QL1)2] CH3OH (Co7), [Co(MDP)(QL1)2] 3H2O (Co8), [Co(ODP)(QL1)2] CH3OH (Co9), [Co(PPT)(QL1)2] CH3OH (Co10), [Co(ClPT)(QL1)2] (Co11), [Co(dpy)(QL3)2] (Co12), [Co(mpy)(QL1)2] (Co13), [Co(Phen)(QL4)2] (Co14), [Co(ODP)(QL4)2] (Co15), [Co(mpy)(QL4)2]I (Co16), [Co(ClPT)(QL4)2] (Co17), and [Co(ClPT)(QL5)2] (Co18), with 5,7-dihalo-8-quinolinol and 2,2"-bipyridine mixed ligands.	12-(4'-azido-2'-nitrophenoxy)dodecanoyl-coenzyme A	245-248	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
31857834-1	2019	Here we first report the design of a series of bis-chelate Co(II) 5,7-dihalo-8-quinolinol-phenanthroline derivative complexes, [Co(py)(QL1)2] (Co1), [Co(py)(QL2)2] (Co2), [Co(Phen)(QL1)2] (Co3), [Co(Phen)(QL2)2] (Co4), [Co(DPQ)(QL1)2] (CH3OH)4 (Co5), [Co(DPQ)(QL2)2] (Co6), [Co(DPPZ)(QL1)2] CH3OH (Co7), [Co(MDP)(QL1)2] 3H2O (Co8), [Co(ODP)(QL1)2] CH3OH (Co9), [Co(PPT)(QL1)2] CH3OH (Co10), [Co(ClPT)(QL1)2] (Co11), [Co(dpy)(QL3)2] (Co12), [Co(mpy)(QL1)2] (Co13), [Co(Phen)(QL4)2] (Co14), [Co(ODP)(QL4)2] (Co15), [Co(mpy)(QL4)2]I (Co16), [Co(ClPT)(QL4)2] (Co17), and [Co(ClPT)(QL5)2] (Co18), with 5,7-dihalo-8-quinolinol and 2,2"-bipyridine mixed ligands.	12-(4'-azido-2'-nitrophenoxy)dodecanoyl-coenzyme A	556-560	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
31857834-1	2019	Here we first report the design of a series of bis-chelate Co(II) 5,7-dihalo-8-quinolinol-phenanthroline derivative complexes, [Co(py)(QL1)2] (Co1), [Co(py)(QL2)2] (Co2), [Co(Phen)(QL1)2] (Co3), [Co(Phen)(QL2)2] (Co4), [Co(DPQ)(QL1)2] (CH3OH)4 (Co5), [Co(DPQ)(QL2)2] (Co6), [Co(DPPZ)(QL1)2] CH3OH (Co7), [Co(MDP)(QL1)2] 3H2O (Co8), [Co(ODP)(QL1)2] CH3OH (Co9), [Co(PPT)(QL1)2] CH3OH (Co10), [Co(ClPT)(QL1)2] (Co11), [Co(dpy)(QL3)2] (Co12), [Co(mpy)(QL1)2] (Co13), [Co(Phen)(QL4)2] (Co14), [Co(ODP)(QL4)2] (Co15), [Co(mpy)(QL4)2]I (Co16), [Co(ClPT)(QL4)2] (Co17), and [Co(ClPT)(QL5)2] (Co18), with 5,7-dihalo-8-quinolinol and 2,2"-bipyridine mixed ligands.	QL9 peptide	567-583	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
31857834-1	2019	Here we first report the design of a series of bis-chelate Co(II) 5,7-dihalo-8-quinolinol-phenanthroline derivative complexes, [Co(py)(QL1)2] (Co1), [Co(py)(QL2)2] (Co2), [Co(Phen)(QL1)2] (Co3), [Co(Phen)(QL2)2] (Co4), [Co(DPQ)(QL1)2] (CH3OH)4 (Co5), [Co(DPQ)(QL2)2] (Co6), [Co(DPPZ)(QL1)2] CH3OH (Co7), [Co(MDP)(QL1)2] 3H2O (Co8), [Co(ODP)(QL1)2] CH3OH (Co9), [Co(PPT)(QL1)2] CH3OH (Co10), [Co(ClPT)(QL1)2] (Co11), [Co(dpy)(QL3)2] (Co12), [Co(mpy)(QL1)2] (Co13), [Co(Phen)(QL4)2] (Co14), [Co(ODP)(QL4)2] (Co15), [Co(mpy)(QL4)2]I (Co16), [Co(ClPT)(QL4)2] (Co17), and [Co(ClPT)(QL5)2] (Co18), with 5,7-dihalo-8-quinolinol and 2,2"-bipyridine mixed ligands.	12-(4'-azido-2'-nitrophenoxy)dodecanoyl-coenzyme A	585-589	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
31857834-1	2019	Here we first report the design of a series of bis-chelate Co(II) 5,7-dihalo-8-quinolinol-phenanthroline derivative complexes, [Co(py)(QL1)2] (Co1), [Co(py)(QL2)2] (Co2), [Co(Phen)(QL1)2] (Co3), [Co(Phen)(QL2)2] (Co4), [Co(DPQ)(QL1)2] (CH3OH)4 (Co5), [Co(DPQ)(QL2)2] (Co6), [Co(DPPZ)(QL1)2] CH3OH (Co7), [Co(MDP)(QL1)2] 3H2O (Co8), [Co(ODP)(QL1)2] CH3OH (Co9), [Co(PPT)(QL1)2] CH3OH (Co10), [Co(ClPT)(QL1)2] (Co11), [Co(dpy)(QL3)2] (Co12), [Co(mpy)(QL1)2] (Co13), [Co(Phen)(QL4)2] (Co14), [Co(ODP)(QL4)2] (Co15), [Co(mpy)(QL4)2]I (Co16), [Co(ClPT)(QL4)2] (Co17), and [Co(ClPT)(QL5)2] (Co18), with 5,7-dihalo-8-quinolinol and 2,2"-bipyridine mixed ligands.	Oxyquinoline	66-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
31857834-1	2019	Here we first report the design of a series of bis-chelate Co(II) 5,7-dihalo-8-quinolinol-phenanthroline derivative complexes, [Co(py)(QL1)2] (Co1), [Co(py)(QL2)2] (Co2), [Co(Phen)(QL1)2] (Co3), [Co(Phen)(QL2)2] (Co4), [Co(DPQ)(QL1)2] (CH3OH)4 (Co5), [Co(DPQ)(QL2)2] (Co6), [Co(DPPZ)(QL1)2] CH3OH (Co7), [Co(MDP)(QL1)2] 3H2O (Co8), [Co(ODP)(QL1)2] CH3OH (Co9), [Co(PPT)(QL1)2] CH3OH (Co10), [Co(ClPT)(QL1)2] (Co11), [Co(dpy)(QL3)2] (Co12), [Co(mpy)(QL1)2] (Co13), [Co(Phen)(QL4)2] (Co14), [Co(ODP)(QL4)2] (Co15), [Co(mpy)(QL4)2]I (Co16), [Co(ClPT)(QL4)2] (Co17), and [Co(ClPT)(QL5)2] (Co18), with 5,7-dihalo-8-quinolinol and 2,2"-bipyridine mixed ligands.	2,2'-Dipyridyl	625-640	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
31857834-1	2019	Here we first report the design of a series of bis-chelate Co(II) 5,7-dihalo-8-quinolinol-phenanthroline derivative complexes, [Co(py)(QL1)2] (Co1), [Co(py)(QL2)2] (Co2), [Co(Phen)(QL1)2] (Co3), [Co(Phen)(QL2)2] (Co4), [Co(DPQ)(QL1)2] (CH3OH)4 (Co5), [Co(DPQ)(QL2)2] (Co6), [Co(DPPZ)(QL1)2] CH3OH (Co7), [Co(MDP)(QL1)2] 3H2O (Co8), [Co(ODP)(QL1)2] CH3OH (Co9), [Co(PPT)(QL1)2] CH3OH (Co10), [Co(ClPT)(QL1)2] (Co11), [Co(dpy)(QL3)2] (Co12), [Co(mpy)(QL1)2] (Co13), [Co(Phen)(QL4)2] (Co14), [Co(ODP)(QL4)2] (Co15), [Co(mpy)(QL4)2]I (Co16), [Co(ClPT)(QL4)2] (Co17), and [Co(ClPT)(QL5)2] (Co18), with 5,7-dihalo-8-quinolinol and 2,2"-bipyridine mixed ligands.	12-(4'-azido-2'-nitrophenoxy)dodecanoyl-coenzyme A	143-146	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
31857834-1	2019	Here we first report the design of a series of bis-chelate Co(II) 5,7-dihalo-8-quinolinol-phenanthroline derivative complexes, [Co(py)(QL1)2] (Co1), [Co(py)(QL2)2] (Co2), [Co(Phen)(QL1)2] (Co3), [Co(Phen)(QL2)2] (Co4), [Co(DPQ)(QL1)2] (CH3OH)4 (Co5), [Co(DPQ)(QL2)2] (Co6), [Co(DPPZ)(QL1)2] CH3OH (Co7), [Co(MDP)(QL1)2] 3H2O (Co8), [Co(ODP)(QL1)2] CH3OH (Co9), [Co(PPT)(QL1)2] CH3OH (Co10), [Co(ClPT)(QL1)2] (Co11), [Co(dpy)(QL3)2] (Co12), [Co(mpy)(QL1)2] (Co13), [Co(Phen)(QL4)2] (Co14), [Co(ODP)(QL4)2] (Co15), [Co(mpy)(QL4)2]I (Co16), [Co(ClPT)(QL4)2] (Co17), and [Co(ClPT)(QL5)2] (Co18), with 5,7-dihalo-8-quinolinol and 2,2"-bipyridine mixed ligands.	QL9 peptide	150-162	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
31857834-1	2019	Here we first report the design of a series of bis-chelate Co(II) 5,7-dihalo-8-quinolinol-phenanthroline derivative complexes, [Co(py)(QL1)2] (Co1), [Co(py)(QL2)2] (Co2), [Co(Phen)(QL1)2] (Co3), [Co(Phen)(QL2)2] (Co4), [Co(DPQ)(QL1)2] (CH3OH)4 (Co5), [Co(DPQ)(QL2)2] (Co6), [Co(DPPZ)(QL1)2] CH3OH (Co7), [Co(MDP)(QL1)2] 3H2O (Co8), [Co(ODP)(QL1)2] CH3OH (Co9), [Co(PPT)(QL1)2] CH3OH (Co10), [Co(ClPT)(QL1)2] (Co11), [Co(dpy)(QL3)2] (Co12), [Co(mpy)(QL1)2] (Co13), [Co(Phen)(QL4)2] (Co14), [Co(ODP)(QL4)2] (Co15), [Co(mpy)(QL4)2]I (Co16), [Co(ClPT)(QL4)2] (Co17), and [Co(ClPT)(QL5)2] (Co18), with 5,7-dihalo-8-quinolinol and 2,2"-bipyridine mixed ligands.	12-(4'-azido-2'-nitrophenoxy)dodecanoyl-coenzyme A	165-168	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
31857834-1	2019	Here we first report the design of a series of bis-chelate Co(II) 5,7-dihalo-8-quinolinol-phenanthroline derivative complexes, [Co(py)(QL1)2] (Co1), [Co(py)(QL2)2] (Co2), [Co(Phen)(QL1)2] (Co3), [Co(Phen)(QL2)2] (Co4), [Co(DPQ)(QL1)2] (CH3OH)4 (Co5), [Co(DPQ)(QL2)2] (Co6), [Co(DPPZ)(QL1)2] CH3OH (Co7), [Co(MDP)(QL1)2] 3H2O (Co8), [Co(ODP)(QL1)2] CH3OH (Co9), [Co(PPT)(QL1)2] CH3OH (Co10), [Co(ClPT)(QL1)2] (Co11), [Co(dpy)(QL3)2] (Co12), [Co(mpy)(QL1)2] (Co13), [Co(Phen)(QL4)2] (Co14), [Co(ODP)(QL4)2] (Co15), [Co(mpy)(QL4)2]I (Co16), [Co(ClPT)(QL4)2] (Co17), and [Co(ClPT)(QL5)2] (Co18), with 5,7-dihalo-8-quinolinol and 2,2"-bipyridine mixed ligands.	triphenanthrolinecobalt(II)	172-180	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
31857834-1	2019	Here we first report the design of a series of bis-chelate Co(II) 5,7-dihalo-8-quinolinol-phenanthroline derivative complexes, [Co(py)(QL1)2] (Co1), [Co(py)(QL2)2] (Co2), [Co(Phen)(QL1)2] (Co3), [Co(Phen)(QL2)2] (Co4), [Co(DPQ)(QL1)2] (CH3OH)4 (Co5), [Co(DPQ)(QL2)2] (Co6), [Co(DPPZ)(QL1)2] CH3OH (Co7), [Co(MDP)(QL1)2] 3H2O (Co8), [Co(ODP)(QL1)2] CH3OH (Co9), [Co(PPT)(QL1)2] CH3OH (Co10), [Co(ClPT)(QL1)2] (Co11), [Co(dpy)(QL3)2] (Co12), [Co(mpy)(QL1)2] (Co13), [Co(Phen)(QL4)2] (Co14), [Co(ODP)(QL4)2] (Co15), [Co(mpy)(QL4)2]I (Co16), [Co(ClPT)(QL4)2] (Co17), and [Co(ClPT)(QL5)2] (Co18), with 5,7-dihalo-8-quinolinol and 2,2"-bipyridine mixed ligands.	12-(4'-azido-2'-nitrophenoxy)dodecanoyl-coenzyme A	189-192	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
31857834-1	2019	Here we first report the design of a series of bis-chelate Co(II) 5,7-dihalo-8-quinolinol-phenanthroline derivative complexes, [Co(py)(QL1)2] (Co1), [Co(py)(QL2)2] (Co2), [Co(Phen)(QL1)2] (Co3), [Co(Phen)(QL2)2] (Co4), [Co(DPQ)(QL1)2] (CH3OH)4 (Co5), [Co(DPQ)(QL2)2] (Co6), [Co(DPPZ)(QL1)2] CH3OH (Co7), [Co(MDP)(QL1)2] 3H2O (Co8), [Co(ODP)(QL1)2] CH3OH (Co9), [Co(PPT)(QL1)2] CH3OH (Co10), [Co(ClPT)(QL1)2] (Co11), [Co(dpy)(QL3)2] (Co12), [Co(mpy)(QL1)2] (Co13), [Co(Phen)(QL4)2] (Co14), [Co(ODP)(QL4)2] (Co15), [Co(mpy)(QL4)2]I (Co16), [Co(ClPT)(QL4)2] (Co17), and [Co(ClPT)(QL5)2] (Co18), with 5,7-dihalo-8-quinolinol and 2,2"-bipyridine mixed ligands.	QL9 peptide	195-211	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
31533969-6	2019	The activation of production of PGE2 (due to activation of COX-2 pathway) seems to be dependent on p38/c-Fos and JNK/c-Jun activation in an AP-1-dependent manner.	Dinoprostone	32-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-64
31857834-1	2019	Here we first report the design of a series of bis-chelate Co(II) 5,7-dihalo-8-quinolinol-phenanthroline derivative complexes, [Co(py)(QL1)2] (Co1), [Co(py)(QL2)2] (Co2), [Co(Phen)(QL1)2] (Co3), [Co(Phen)(QL2)2] (Co4), [Co(DPQ)(QL1)2] (CH3OH)4 (Co5), [Co(DPQ)(QL2)2] (Co6), [Co(DPPZ)(QL1)2] CH3OH (Co7), [Co(MDP)(QL1)2] 3H2O (Co8), [Co(ODP)(QL1)2] CH3OH (Co9), [Co(PPT)(QL1)2] CH3OH (Co10), [Co(ClPT)(QL1)2] (Co11), [Co(dpy)(QL3)2] (Co12), [Co(mpy)(QL1)2] (Co13), [Co(Phen)(QL4)2] (Co14), [Co(ODP)(QL4)2] (Co15), [Co(mpy)(QL4)2]I (Co16), [Co(ClPT)(QL4)2] (Co17), and [Co(ClPT)(QL5)2] (Co18), with 5,7-dihalo-8-quinolinol and 2,2"-bipyridine mixed ligands.	2,6-diisopropyl-1,4-quinol	219-243	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
31663670-6	2019	Chronoamperometric response evidences the stability of the material for the overall water-splitting up to 24 h. Post characterization of the catalyst after OER and HER shows the presence of mixed Co(II) and Co(III) oxidation state.	ERBB2 protein, human	164-167	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	196-202
31665187-0	2019	Correction: Celecoxib enhances the sensitivity of non-small-cell lung cancer cells to radiation-induced apoptosis through downregulation of the Akt/mTOR signaling pathway and COX-2 expression.	celecoxib	12-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	175-180
31387029-5	2019	Then, the immobilized COX-2 with different activities were prepared using different immobilization methods, including Ni2+ affinity-oriented immobilization, polydopamine (PDA) covalent immobilization, and conventional glutaraldehyde (GA) covalent immobilization.	Nickel(2+)	118-122	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-27
31387029-5	2019	Then, the immobilized COX-2 with different activities were prepared using different immobilization methods, including Ni2+ affinity-oriented immobilization, polydopamine (PDA) covalent immobilization, and conventional glutaraldehyde (GA) covalent immobilization.	polydopamine	157-169	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-27
31387029-5	2019	Then, the immobilized COX-2 with different activities were prepared using different immobilization methods, including Ni2+ affinity-oriented immobilization, polydopamine (PDA) covalent immobilization, and conventional glutaraldehyde (GA) covalent immobilization.	polydopamine	171-174	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-27
31387029-5	2019	Then, the immobilized COX-2 with different activities were prepared using different immobilization methods, including Ni2+ affinity-oriented immobilization, polydopamine (PDA) covalent immobilization, and conventional glutaraldehyde (GA) covalent immobilization.	Glutaral	218-232	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-27
31387029-5	2019	Then, the immobilized COX-2 with different activities were prepared using different immobilization methods, including Ni2+ affinity-oriented immobilization, polydopamine (PDA) covalent immobilization, and conventional glutaraldehyde (GA) covalent immobilization.	Glutaral	234-236	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-27
31853218-2	2019	As a consequence of genetic, immune and environmental factors, endometriotic lesions have high cyclooxygenase (COX)-2 and COX-2-derived prostaglandin E2 (PGE2) biosynthesis compared with the normal endometrium.	Dinoprostone	136-152	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-127
31853218-2	2019	As a consequence of genetic, immune and environmental factors, endometriotic lesions have high cyclooxygenase (COX)-2 and COX-2-derived prostaglandin E2 (PGE2) biosynthesis compared with the normal endometrium.	Dinoprostone	154-158	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-127
31853218-4	2019	COX-2 expression can be regulated by several factors, such as estrogen, hypoxia, proinflammatory cytokines, environmental pollutants, metabolites and metabolic enzymes, and platelets.	Estrogens	62-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
31853218-6	2019	COX-2-derived PGE2 performs a crucial function in EMS development by binding to EP2 and EP4 receptors.	Dinoprostone	14-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
31853218-7	2019	These basic findings have contributed to COX-2-targeted treatment in EMS, including COX-2 inhibitors, hormone drugs and glycyrrhizin.	Glycyrrhizic Acid	120-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-46
31247880-5	2019	CoII titrations reveal that both metallochaperones have similar electronic absorption characteristics that indicate the presence of two tetrahedral metal coordination sites.	Metals	33-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-4
31709090-3	2019	Thermogravimetric measurements prove that, upon heating, the title com-plex loses the two aceto-nitrile ligands and transforms into a new crystalline modification of the chain com-pound [Ni(NCS)2(4-benzoyl-pyridine)2], which is different from that of the corresponding CoII, NiII and CdII coordination polymers reported in the literature.	Nitriles	90-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	269-273
31709090-3	2019	Thermogravimetric measurements prove that, upon heating, the title com-plex loses the two aceto-nitrile ligands and transforms into a new crystalline modification of the chain com-pound [Ni(NCS)2(4-benzoyl-pyridine)2], which is different from that of the corresponding CoII, NiII and CdII coordination polymers reported in the literature.	Nickel	187-216	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	269-273
31709090-3	2019	Thermogravimetric measurements prove that, upon heating, the title com-plex loses the two aceto-nitrile ligands and transforms into a new crystalline modification of the chain com-pound [Ni(NCS)2(4-benzoyl-pyridine)2], which is different from that of the corresponding CoII, NiII and CdII coordination polymers reported in the literature.	Nickel	275-279	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	269-273
31709090-3	2019	Thermogravimetric measurements prove that, upon heating, the title com-plex loses the two aceto-nitrile ligands and transforms into a new crystalline modification of the chain com-pound [Ni(NCS)2(4-benzoyl-pyridine)2], which is different from that of the corresponding CoII, NiII and CdII coordination polymers reported in the literature.	Cadmium	284-288	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	269-273
31247880-6	2019	High-affinity metal binding at the CXCC motif activates the GTPase activity of both enzymes, with ZnII more effective than CoII.	Metals	14-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-127
31635294-5	2019	We found that AGR pretreatment strongly inhibits the production of nitric oxide (NO), cytokines, and the enzymes inducible nitric oxide synthase (iNOS), and cyclooxygenase (COX)-2, and effectively induces the activation of heme oxygenase (HO)-1 and its regulator, nuclear factor erythroid 2-related factor 2 (Nrf-2).	alanylglycylarginine	14-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	157-179
31623608-0	2019	pH and redox dual-responsive nanoparticles based on disulfide-containing poly(beta-amino ester) for combining chemotherapy and COX-2 inhibitor to overcome drug resistance in breast cancer.	Disulfides	52-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	127-132
31623608-0	2019	pH and redox dual-responsive nanoparticles based on disulfide-containing poly(beta-amino ester) for combining chemotherapy and COX-2 inhibitor to overcome drug resistance in breast cancer.	poly(beta-amino ester)	73-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	127-132
31623608-3	2019	Celecoxib (CXB), a selective COX-2 inhibitor, can dramatically enhance the cytotoxicity of doxorubicin (DOX) in breast cancer cells overexpressing P-gp.	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34
31623608-3	2019	Celecoxib (CXB), a selective COX-2 inhibitor, can dramatically enhance the cytotoxicity of doxorubicin (DOX) in breast cancer cells overexpressing P-gp.	Celecoxib	11-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34
31623608-3	2019	Celecoxib (CXB), a selective COX-2 inhibitor, can dramatically enhance the cytotoxicity of doxorubicin (DOX) in breast cancer cells overexpressing P-gp.	Doxorubicin	91-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34
31623608-3	2019	Celecoxib (CXB), a selective COX-2 inhibitor, can dramatically enhance the cytotoxicity of doxorubicin (DOX) in breast cancer cells overexpressing P-gp.	Doxorubicin	104-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34
31623608-7	2019	In drug-resistant human breast cancer MCF-7/ADR cells, HPPDC nanoparticles significantly enhanced the cellular uptake of DOX through the endocytosis mediated by CD44/HA specific binding and the down-regulated P-gp expression induced by COX-2 inhibition, and thus notably increased the cytotoxicity and apoptosis-inducing activity of DOX.	Doxorubicin	121-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	236-241
31421826-3	2019	Trans-cinnamaldehyde (TCA) is an excellent COX-2 inhibitor in central nervous system which is a main constituent of GUIZHI as a member of traditional Chinese herb.	cinnamaldehyde	0-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
31421826-3	2019	Trans-cinnamaldehyde (TCA) is an excellent COX-2 inhibitor in central nervous system which is a main constituent of GUIZHI as a member of traditional Chinese herb.	cinnamaldehyde	22-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
31302096-10	2019	Co-injection of glucocorticoid receptor (GR) antagonist RU486, COX2 inhibitor NS-398, EP4 receptor antagonist L161,982 or TRPV1 antagonist capsazepine prevented 3d restraint stress prolonged sensitization pain evoked by PGE2.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	78-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-67
31306939-6	2019	SO4 - was produced through the activation of peroxymonosulfate (PMS) by Co(II) ions at pH 8 in borate buffer.	sulfuric acid	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-78
31857834-1	2019	Here we first report the design of a series of bis-chelate Co(II) 5,7-dihalo-8-quinolinol-phenanthroline derivative complexes, [Co(py)(QL1)2] (Co1), [Co(py)(QL2)2] (Co2), [Co(Phen)(QL1)2] (Co3), [Co(Phen)(QL2)2] (Co4), [Co(DPQ)(QL1)2] (CH3OH)4 (Co5), [Co(DPQ)(QL2)2] (Co6), [Co(DPPZ)(QL1)2] CH3OH (Co7), [Co(MDP)(QL1)2] 3H2O (Co8), [Co(ODP)(QL1)2] CH3OH (Co9), [Co(PPT)(QL1)2] CH3OH (Co10), [Co(ClPT)(QL1)2] (Co11), [Co(dpy)(QL3)2] (Co12), [Co(mpy)(QL1)2] (Co13), [Co(Phen)(QL4)2] (Co14), [Co(ODP)(QL4)2] (Co15), [Co(mpy)(QL4)2]I (Co16), [Co(ClPT)(QL4)2] (Co17), and [Co(ClPT)(QL5)2] (Co18), with 5,7-dihalo-8-quinolinol and 2,2"-bipyridine mixed ligands.	2,6-diisopropyl-1,4-quinol	251-266	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
31857834-1	2019	Here we first report the design of a series of bis-chelate Co(II) 5,7-dihalo-8-quinolinol-phenanthroline derivative complexes, [Co(py)(QL1)2] (Co1), [Co(py)(QL2)2] (Co2), [Co(Phen)(QL1)2] (Co3), [Co(Phen)(QL2)2] (Co4), [Co(DPQ)(QL1)2] (CH3OH)4 (Co5), [Co(DPQ)(QL2)2] (Co6), [Co(DPPZ)(QL1)2] CH3OH (Co7), [Co(MDP)(QL1)2] 3H2O (Co8), [Co(ODP)(QL1)2] CH3OH (Co9), [Co(PPT)(QL1)2] CH3OH (Co10), [Co(ClPT)(QL1)2] (Co11), [Co(dpy)(QL3)2] (Co12), [Co(mpy)(QL1)2] (Co13), [Co(Phen)(QL4)2] (Co14), [Co(ODP)(QL4)2] (Co15), [Co(mpy)(QL4)2]I (Co16), [Co(ClPT)(QL4)2] (Co17), and [Co(ClPT)(QL5)2] (Co18), with 5,7-dihalo-8-quinolinol and 2,2"-bipyridine mixed ligands.	12-(4'-azido-2'-nitrophenoxy)dodecanoyl-coenzyme A	268-271	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
31857834-1	2019	Here we first report the design of a series of bis-chelate Co(II) 5,7-dihalo-8-quinolinol-phenanthroline derivative complexes, [Co(py)(QL1)2] (Co1), [Co(py)(QL2)2] (Co2), [Co(Phen)(QL1)2] (Co3), [Co(Phen)(QL2)2] (Co4), [Co(DPQ)(QL1)2] (CH3OH)4 (Co5), [Co(DPQ)(QL2)2] (Co6), [Co(DPPZ)(QL1)2] CH3OH (Co7), [Co(MDP)(QL1)2] 3H2O (Co8), [Co(ODP)(QL1)2] CH3OH (Co9), [Co(PPT)(QL1)2] CH3OH (Co10), [Co(ClPT)(QL1)2] (Co11), [Co(dpy)(QL3)2] (Co12), [Co(mpy)(QL1)2] (Co13), [Co(Phen)(QL4)2] (Co14), [Co(ODP)(QL4)2] (Co15), [Co(mpy)(QL4)2]I (Co16), [Co(ClPT)(QL4)2] (Co17), and [Co(ClPT)(QL5)2] (Co18), with 5,7-dihalo-8-quinolinol and 2,2"-bipyridine mixed ligands.	dipyrido(3,2-a-2',3'-c)phenazine	274-296	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
31857834-1	2019	Here we first report the design of a series of bis-chelate Co(II) 5,7-dihalo-8-quinolinol-phenanthroline derivative complexes, [Co(py)(QL1)2] (Co1), [Co(py)(QL2)2] (Co2), [Co(Phen)(QL1)2] (Co3), [Co(Phen)(QL2)2] (Co4), [Co(DPQ)(QL1)2] (CH3OH)4 (Co5), [Co(DPQ)(QL2)2] (Co6), [Co(DPPZ)(QL1)2] CH3OH (Co7), [Co(MDP)(QL1)2] 3H2O (Co8), [Co(ODP)(QL1)2] CH3OH (Co9), [Co(PPT)(QL1)2] CH3OH (Co10), [Co(ClPT)(QL1)2] (Co11), [Co(dpy)(QL3)2] (Co12), [Co(mpy)(QL1)2] (Co13), [Co(Phen)(QL4)2] (Co14), [Co(ODP)(QL4)2] (Co15), [Co(mpy)(QL4)2]I (Co16), [Co(ClPT)(QL4)2] (Co17), and [Co(ClPT)(QL5)2] (Co18), with 5,7-dihalo-8-quinolinol and 2,2"-bipyridine mixed ligands.	QL9 peptide	304-330	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
31857834-1	2019	Here we first report the design of a series of bis-chelate Co(II) 5,7-dihalo-8-quinolinol-phenanthroline derivative complexes, [Co(py)(QL1)2] (Co1), [Co(py)(QL2)2] (Co2), [Co(Phen)(QL1)2] (Co3), [Co(Phen)(QL2)2] (Co4), [Co(DPQ)(QL1)2] (CH3OH)4 (Co5), [Co(DPQ)(QL2)2] (Co6), [Co(DPPZ)(QL1)2] CH3OH (Co7), [Co(MDP)(QL1)2] 3H2O (Co8), [Co(ODP)(QL1)2] CH3OH (Co9), [Co(PPT)(QL1)2] CH3OH (Co10), [Co(ClPT)(QL1)2] (Co11), [Co(dpy)(QL3)2] (Co12), [Co(mpy)(QL1)2] (Co13), [Co(Phen)(QL4)2] (Co14), [Co(ODP)(QL4)2] (Co15), [Co(mpy)(QL4)2]I (Co16), [Co(ClPT)(QL4)2] (Co17), and [Co(ClPT)(QL5)2] (Co18), with 5,7-dihalo-8-quinolinol and 2,2"-bipyridine mixed ligands.	N-(2-methyl-3-oxodecanoyl)-2-pyrroline	332-353	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
31857834-1	2019	Here we first report the design of a series of bis-chelate Co(II) 5,7-dihalo-8-quinolinol-phenanthroline derivative complexes, [Co(py)(QL1)2] (Co1), [Co(py)(QL2)2] (Co2), [Co(Phen)(QL1)2] (Co3), [Co(Phen)(QL2)2] (Co4), [Co(DPQ)(QL1)2] (CH3OH)4 (Co5), [Co(DPQ)(QL2)2] (Co6), [Co(DPPZ)(QL1)2] CH3OH (Co7), [Co(MDP)(QL1)2] 3H2O (Co8), [Co(ODP)(QL1)2] CH3OH (Co9), [Co(PPT)(QL1)2] CH3OH (Co10), [Co(ClPT)(QL1)2] (Co11), [Co(dpy)(QL3)2] (Co12), [Co(mpy)(QL1)2] (Co13), [Co(Phen)(QL4)2] (Co14), [Co(ODP)(QL4)2] (Co15), [Co(mpy)(QL4)2]I (Co16), [Co(ClPT)(QL4)2] (Co17), and [Co(ClPT)(QL5)2] (Co18), with 5,7-dihalo-8-quinolinol and 2,2"-bipyridine mixed ligands.	4H-3-(2-phenoxy)phenyl-1,2,4-triazole	362-369	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
31857834-1	2019	Here we first report the design of a series of bis-chelate Co(II) 5,7-dihalo-8-quinolinol-phenanthroline derivative complexes, [Co(py)(QL1)2] (Co1), [Co(py)(QL2)2] (Co2), [Co(Phen)(QL1)2] (Co3), [Co(Phen)(QL2)2] (Co4), [Co(DPQ)(QL1)2] (CH3OH)4 (Co5), [Co(DPQ)(QL2)2] (Co6), [Co(DPPZ)(QL1)2] CH3OH (Co7), [Co(MDP)(QL1)2] 3H2O (Co8), [Co(ODP)(QL1)2] CH3OH (Co9), [Co(PPT)(QL1)2] CH3OH (Co10), [Co(ClPT)(QL1)2] (Co11), [Co(dpy)(QL3)2] (Co12), [Co(mpy)(QL1)2] (Co13), [Co(Phen)(QL4)2] (Co14), [Co(ODP)(QL4)2] (Co15), [Co(mpy)(QL4)2]I (Co16), [Co(ClPT)(QL4)2] (Co17), and [Co(ClPT)(QL5)2] (Co18), with 5,7-dihalo-8-quinolinol and 2,2"-bipyridine mixed ligands.	N-methyl perfluorobutane sulfonamidoethanol	236-241	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
31857834-1	2019	Here we first report the design of a series of bis-chelate Co(II) 5,7-dihalo-8-quinolinol-phenanthroline derivative complexes, [Co(py)(QL1)2] (Co1), [Co(py)(QL2)2] (Co2), [Co(Phen)(QL1)2] (Co3), [Co(Phen)(QL2)2] (Co4), [Co(DPQ)(QL1)2] (CH3OH)4 (Co5), [Co(DPQ)(QL2)2] (Co6), [Co(DPPZ)(QL1)2] CH3OH (Co7), [Co(MDP)(QL1)2] 3H2O (Co8), [Co(ODP)(QL1)2] CH3OH (Co9), [Co(PPT)(QL1)2] CH3OH (Co10), [Co(ClPT)(QL1)2] (Co11), [Co(dpy)(QL3)2] (Co12), [Co(mpy)(QL1)2] (Co13), [Co(Phen)(QL4)2] (Co14), [Co(ODP)(QL4)2] (Co15), [Co(mpy)(QL4)2]I (Co16), [Co(ClPT)(QL4)2] (Co17), and [Co(ClPT)(QL5)2] (Co18), with 5,7-dihalo-8-quinolinol and 2,2"-bipyridine mixed ligands.	12-(4'-azido-2'-nitrophenoxy)dodecanoyl-coenzyme A	384-388	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
31857834-1	2019	Here we first report the design of a series of bis-chelate Co(II) 5,7-dihalo-8-quinolinol-phenanthroline derivative complexes, [Co(py)(QL1)2] (Co1), [Co(py)(QL2)2] (Co2), [Co(Phen)(QL1)2] (Co3), [Co(Phen)(QL2)2] (Co4), [Co(DPQ)(QL1)2] (CH3OH)4 (Co5), [Co(DPQ)(QL2)2] (Co6), [Co(DPPZ)(QL1)2] CH3OH (Co7), [Co(MDP)(QL1)2] 3H2O (Co8), [Co(ODP)(QL1)2] CH3OH (Co9), [Co(PPT)(QL1)2] CH3OH (Co10), [Co(ClPT)(QL1)2] (Co11), [Co(dpy)(QL3)2] (Co12), [Co(mpy)(QL1)2] (Co13), [Co(Phen)(QL4)2] (Co14), [Co(ODP)(QL4)2] (Co15), [Co(mpy)(QL4)2]I (Co16), [Co(ClPT)(QL4)2] (Co17), and [Co(ClPT)(QL5)2] (Co18), with 5,7-dihalo-8-quinolinol and 2,2"-bipyridine mixed ligands.	6-(4-N-piperidinylphenyl)azobenzothiazole	395-399	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
31857834-1	2019	Here we first report the design of a series of bis-chelate Co(II) 5,7-dihalo-8-quinolinol-phenanthroline derivative complexes, [Co(py)(QL1)2] (Co1), [Co(py)(QL2)2] (Co2), [Co(Phen)(QL1)2] (Co3), [Co(Phen)(QL2)2] (Co4), [Co(DPQ)(QL1)2] (CH3OH)4 (Co5), [Co(DPQ)(QL2)2] (Co6), [Co(DPPZ)(QL1)2] CH3OH (Co7), [Co(MDP)(QL1)2] 3H2O (Co8), [Co(ODP)(QL1)2] CH3OH (Co9), [Co(PPT)(QL1)2] CH3OH (Co10), [Co(ClPT)(QL1)2] (Co11), [Co(dpy)(QL3)2] (Co12), [Co(mpy)(QL1)2] (Co13), [Co(Phen)(QL4)2] (Co14), [Co(ODP)(QL4)2] (Co15), [Co(mpy)(QL4)2]I (Co16), [Co(ClPT)(QL4)2] (Co17), and [Co(ClPT)(QL5)2] (Co18), with 5,7-dihalo-8-quinolinol and 2,2"-bipyridine mixed ligands.	12-(4'-azido-2'-nitrophenoxy)dodecanoyl-coenzyme A	409-413	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
31857834-1	2019	Here we first report the design of a series of bis-chelate Co(II) 5,7-dihalo-8-quinolinol-phenanthroline derivative complexes, [Co(py)(QL1)2] (Co1), [Co(py)(QL2)2] (Co2), [Co(Phen)(QL1)2] (Co3), [Co(Phen)(QL2)2] (Co4), [Co(DPQ)(QL1)2] (CH3OH)4 (Co5), [Co(DPQ)(QL2)2] (Co6), [Co(DPPZ)(QL1)2] CH3OH (Co7), [Co(MDP)(QL1)2] 3H2O (Co8), [Co(ODP)(QL1)2] CH3OH (Co9), [Co(PPT)(QL1)2] CH3OH (Co10), [Co(ClPT)(QL1)2] (Co11), [Co(dpy)(QL3)2] (Co12), [Co(mpy)(QL1)2] (Co13), [Co(Phen)(QL4)2] (Co14), [Co(ODP)(QL4)2] (Co15), [Co(mpy)(QL4)2]I (Co16), [Co(ClPT)(QL4)2] (Co17), and [Co(ClPT)(QL5)2] (Co18), with 5,7-dihalo-8-quinolinol and 2,2"-bipyridine mixed ligands.	QL9 peptide	416-431	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
31857834-1	2019	Here we first report the design of a series of bis-chelate Co(II) 5,7-dihalo-8-quinolinol-phenanthroline derivative complexes, [Co(py)(QL1)2] (Co1), [Co(py)(QL2)2] (Co2), [Co(Phen)(QL1)2] (Co3), [Co(Phen)(QL2)2] (Co4), [Co(DPQ)(QL1)2] (CH3OH)4 (Co5), [Co(DPQ)(QL2)2] (Co6), [Co(DPPZ)(QL1)2] CH3OH (Co7), [Co(MDP)(QL1)2] 3H2O (Co8), [Co(ODP)(QL1)2] CH3OH (Co9), [Co(PPT)(QL1)2] CH3OH (Co10), [Co(ClPT)(QL1)2] (Co11), [Co(dpy)(QL3)2] (Co12), [Co(mpy)(QL1)2] (Co13), [Co(Phen)(QL4)2] (Co14), [Co(ODP)(QL4)2] (Co15), [Co(mpy)(QL4)2]I (Co16), [Co(ClPT)(QL4)2] (Co17), and [Co(ClPT)(QL5)2] (Co18), with 5,7-dihalo-8-quinolinol and 2,2"-bipyridine mixed ligands.	AN 12	433-437	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
31857834-1	2019	Here we first report the design of a series of bis-chelate Co(II) 5,7-dihalo-8-quinolinol-phenanthroline derivative complexes, [Co(py)(QL1)2] (Co1), [Co(py)(QL2)2] (Co2), [Co(Phen)(QL1)2] (Co3), [Co(Phen)(QL2)2] (Co4), [Co(DPQ)(QL1)2] (CH3OH)4 (Co5), [Co(DPQ)(QL2)2] (Co6), [Co(DPPZ)(QL1)2] CH3OH (Co7), [Co(MDP)(QL1)2] 3H2O (Co8), [Co(ODP)(QL1)2] CH3OH (Co9), [Co(PPT)(QL1)2] CH3OH (Co10), [Co(ClPT)(QL1)2] (Co11), [Co(dpy)(QL3)2] (Co12), [Co(mpy)(QL1)2] (Co13), [Co(Phen)(QL4)2] (Co14), [Co(ODP)(QL4)2] (Co15), [Co(mpy)(QL4)2]I (Co16), [Co(ClPT)(QL4)2] (Co17), and [Co(ClPT)(QL5)2] (Co18), with 5,7-dihalo-8-quinolinol and 2,2"-bipyridine mixed ligands.	acetyl-arginyl-arginyl-methionyl-tyrosyl-arginyl-arginyl-isoleucyl-tyrosyl-arginyl-argininamide	457-461	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
31857834-1	2019	Here we first report the design of a series of bis-chelate Co(II) 5,7-dihalo-8-quinolinol-phenanthroline derivative complexes, [Co(py)(QL1)2] (Co1), [Co(py)(QL2)2] (Co2), [Co(Phen)(QL1)2] (Co3), [Co(Phen)(QL2)2] (Co4), [Co(DPQ)(QL1)2] (CH3OH)4 (Co5), [Co(DPQ)(QL2)2] (Co6), [Co(DPPZ)(QL1)2] CH3OH (Co7), [Co(MDP)(QL1)2] 3H2O (Co8), [Co(ODP)(QL1)2] CH3OH (Co9), [Co(PPT)(QL1)2] CH3OH (Co10), [Co(ClPT)(QL1)2] (Co11), [Co(dpy)(QL3)2] (Co12), [Co(mpy)(QL1)2] (Co13), [Co(Phen)(QL4)2] (Co14), [Co(ODP)(QL4)2] (Co15), [Co(mpy)(QL4)2]I (Co16), [Co(ClPT)(QL4)2] (Co17), and [Co(ClPT)(QL5)2] (Co18), with 5,7-dihalo-8-quinolinol and 2,2"-bipyridine mixed ligands.	QL9 peptide	464-480	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
31857834-1	2019	Here we first report the design of a series of bis-chelate Co(II) 5,7-dihalo-8-quinolinol-phenanthroline derivative complexes, [Co(py)(QL1)2] (Co1), [Co(py)(QL2)2] (Co2), [Co(Phen)(QL1)2] (Co3), [Co(Phen)(QL2)2] (Co4), [Co(DPQ)(QL1)2] (CH3OH)4 (Co5), [Co(DPQ)(QL2)2] (Co6), [Co(DPPZ)(QL1)2] CH3OH (Co7), [Co(MDP)(QL1)2] 3H2O (Co8), [Co(ODP)(QL1)2] CH3OH (Co9), [Co(PPT)(QL1)2] CH3OH (Co10), [Co(ClPT)(QL1)2] (Co11), [Co(dpy)(QL3)2] (Co12), [Co(mpy)(QL1)2] (Co13), [Co(Phen)(QL4)2] (Co14), [Co(ODP)(QL4)2] (Co15), [Co(mpy)(QL4)2]I (Co16), [Co(ClPT)(QL4)2] (Co17), and [Co(ClPT)(QL5)2] (Co18), with 5,7-dihalo-8-quinolinol and 2,2"-bipyridine mixed ligands.	12-(4'-azido-2'-nitrophenoxy)dodecanoyl-coenzyme A	482-486	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
31857834-1	2019	Here we first report the design of a series of bis-chelate Co(II) 5,7-dihalo-8-quinolinol-phenanthroline derivative complexes, [Co(py)(QL1)2] (Co1), [Co(py)(QL2)2] (Co2), [Co(Phen)(QL1)2] (Co3), [Co(Phen)(QL2)2] (Co4), [Co(DPQ)(QL1)2] (CH3OH)4 (Co5), [Co(DPQ)(QL2)2] (Co6), [Co(DPPZ)(QL1)2] CH3OH (Co7), [Co(MDP)(QL1)2] 3H2O (Co8), [Co(ODP)(QL1)2] CH3OH (Co9), [Co(PPT)(QL1)2] CH3OH (Co10), [Co(ClPT)(QL1)2] (Co11), [Co(dpy)(QL3)2] (Co12), [Co(mpy)(QL1)2] (Co13), [Co(Phen)(QL4)2] (Co14), [Co(ODP)(QL4)2] (Co15), [Co(mpy)(QL4)2]I (Co16), [Co(ClPT)(QL4)2] (Co17), and [Co(ClPT)(QL5)2] (Co18), with 5,7-dihalo-8-quinolinol and 2,2"-bipyridine mixed ligands.	N-(2-methyl-3-oxodecanoyl)-2-pyrroline	489-504	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
31857834-1	2019	Here we first report the design of a series of bis-chelate Co(II) 5,7-dihalo-8-quinolinol-phenanthroline derivative complexes, [Co(py)(QL1)2] (Co1), [Co(py)(QL2)2] (Co2), [Co(Phen)(QL1)2] (Co3), [Co(Phen)(QL2)2] (Co4), [Co(DPQ)(QL1)2] (CH3OH)4 (Co5), [Co(DPQ)(QL2)2] (Co6), [Co(DPPZ)(QL1)2] CH3OH (Co7), [Co(MDP)(QL1)2] 3H2O (Co8), [Co(ODP)(QL1)2] CH3OH (Co9), [Co(PPT)(QL1)2] CH3OH (Co10), [Co(ClPT)(QL1)2] (Co11), [Co(dpy)(QL3)2] (Co12), [Co(mpy)(QL1)2] (Co13), [Co(Phen)(QL4)2] (Co14), [Co(ODP)(QL4)2] (Co15), [Co(mpy)(QL4)2]I (Co16), [Co(ClPT)(QL4)2] (Co17), and [Co(ClPT)(QL5)2] (Co18), with 5,7-dihalo-8-quinolinol and 2,2"-bipyridine mixed ligands.	12-(4'-azido-2'-nitrophenoxy)dodecanoyl-coenzyme A	506-510	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
31857834-1	2019	Here we first report the design of a series of bis-chelate Co(II) 5,7-dihalo-8-quinolinol-phenanthroline derivative complexes, [Co(py)(QL1)2] (Co1), [Co(py)(QL2)2] (Co2), [Co(Phen)(QL1)2] (Co3), [Co(Phen)(QL2)2] (Co4), [Co(DPQ)(QL1)2] (CH3OH)4 (Co5), [Co(DPQ)(QL2)2] (Co6), [Co(DPPZ)(QL1)2] CH3OH (Co7), [Co(MDP)(QL1)2] 3H2O (Co8), [Co(ODP)(QL1)2] CH3OH (Co9), [Co(PPT)(QL1)2] CH3OH (Co10), [Co(ClPT)(QL1)2] (Co11), [Co(dpy)(QL3)2] (Co12), [Co(mpy)(QL1)2] (Co13), [Co(Phen)(QL4)2] (Co14), [Co(ODP)(QL4)2] (Co15), [Co(mpy)(QL4)2]I (Co16), [Co(ClPT)(QL4)2] (Co17), and [Co(ClPT)(QL5)2] (Co18), with 5,7-dihalo-8-quinolinol and 2,2"-bipyridine mixed ligands.	QL9 peptide	513-529	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
31857834-1	2019	Here we first report the design of a series of bis-chelate Co(II) 5,7-dihalo-8-quinolinol-phenanthroline derivative complexes, [Co(py)(QL1)2] (Co1), [Co(py)(QL2)2] (Co2), [Co(Phen)(QL1)2] (Co3), [Co(Phen)(QL2)2] (Co4), [Co(DPQ)(QL1)2] (CH3OH)4 (Co5), [Co(DPQ)(QL2)2] (Co6), [Co(DPPZ)(QL1)2] CH3OH (Co7), [Co(MDP)(QL1)2] 3H2O (Co8), [Co(ODP)(QL1)2] CH3OH (Co9), [Co(PPT)(QL1)2] CH3OH (Co10), [Co(ClPT)(QL1)2] (Co11), [Co(dpy)(QL3)2] (Co12), [Co(mpy)(QL1)2] (Co13), [Co(Phen)(QL4)2] (Co14), [Co(ODP)(QL4)2] (Co15), [Co(mpy)(QL4)2]I (Co16), [Co(ClPT)(QL4)2] (Co17), and [Co(ClPT)(QL5)2] (Co18), with 5,7-dihalo-8-quinolinol and 2,2"-bipyridine mixed ligands.	12-(4'-azido-2'-nitrophenoxy)dodecanoyl-coenzyme A	531-535	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
31857834-1	2019	Here we first report the design of a series of bis-chelate Co(II) 5,7-dihalo-8-quinolinol-phenanthroline derivative complexes, [Co(py)(QL1)2] (Co1), [Co(py)(QL2)2] (Co2), [Co(Phen)(QL1)2] (Co3), [Co(Phen)(QL2)2] (Co4), [Co(DPQ)(QL1)2] (CH3OH)4 (Co5), [Co(DPQ)(QL2)2] (Co6), [Co(DPPZ)(QL1)2] CH3OH (Co7), [Co(MDP)(QL1)2] 3H2O (Co8), [Co(ODP)(QL1)2] CH3OH (Co9), [Co(PPT)(QL1)2] CH3OH (Co10), [Co(ClPT)(QL1)2] (Co11), [Co(dpy)(QL3)2] (Co12), [Co(mpy)(QL1)2] (Co13), [Co(Phen)(QL4)2] (Co14), [Co(ODP)(QL4)2] (Co15), [Co(mpy)(QL4)2]I (Co16), [Co(ClPT)(QL4)2] (Co17), and [Co(ClPT)(QL5)2] (Co18), with 5,7-dihalo-8-quinolinol and 2,2"-bipyridine mixed ligands.	QL9 peptide	539-553	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
31556414-11	2019	Redox tunability was achieved by appending push-pull substituents at the beta-position of the MTPP (M = 2H, CoII, NiII, CuII, and ZnII) skeleton of the macrocycle.	4-methacryloylamino-2,2,6,6-tetramethylpiperidine	94-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-112
31306939-6	2019	SO4 - was produced through the activation of peroxymonosulfate (PMS) by Co(II) ions at pH 8 in borate buffer.	peroxymonosulfate	45-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-78
31306939-6	2019	SO4 - was produced through the activation of peroxymonosulfate (PMS) by Co(II) ions at pH 8 in borate buffer.	peroxymonosulfate	64-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-78
31306939-6	2019	SO4 - was produced through the activation of peroxymonosulfate (PMS) by Co(II) ions at pH 8 in borate buffer.	Borates	95-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-78
31611604-0	2019	Targeting the COX2/MET/TOPK signaling axis induces apoptosis in gefitinib-resistant NSCLC cells.	Gefitinib	64-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-18
32002054-0	2019	Curcumin"s Effect on COX-2 and IL-10 Serum in Preeclampsia"s Patient Undergo Sectio Caesarea with Spinal Anesthesia.	Curcumin	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-26
31611604-4	2019	In addition, the inhibition of HCC827GR cell growth by combining COX2 inhibitor (celecoxib), TOPK inhibitor (pantoprazole), and gefitinib was verified ex vivo and in vivo.	Celecoxib	81-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-69
31611604-6	2019	Then, we observed that the COX2-TXA2 signaling pathway modulated MET through AP-1, resulting in an inhibition of apoptosis in gefitinib-resistant cells.	Gefitinib	126-135	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-31
31611604-9	2019	Our work reveals a novel COX2/MET/TOPK signaling axis that can prevent apoptosis in gefitinib-resistant cells and suggests that a triple combination of FDA-approved drugs would provide a low-cost and practical strategy to overcome gefitinib resistance.	Gefitinib	84-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-29
31611604-9	2019	Our work reveals a novel COX2/MET/TOPK signaling axis that can prevent apoptosis in gefitinib-resistant cells and suggests that a triple combination of FDA-approved drugs would provide a low-cost and practical strategy to overcome gefitinib resistance.	Gefitinib	231-240	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-29
32002054-2	2019	Curcumin affects several biological markers that are thought to play a role in the pathogenesis of preeclampsia such as IL-10 and COX-2, resulting in an improvement in pregnant women with preeclampsia.	Curcumin	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	130-135
32002054-3	2019	AIM: To see the effect of perioperative curcumin administration on IL-10 and COX-2 in preeclamptic patients undergoing caesarean section under spinal anaesthesia.	Curcumin	40-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-82
31687075-8	2019	The ability of the SB to modulate oxidative stress was assessed by measuring MDA, TNF-alpha, SOD1, COX2, and NOS2 levels in vitro, using human endothelial cell cultures exposed to a glucose-enriched medium.	Schiff Bases	19-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-103
31560017-1	2019	Self-assembly reactions of CoII ions in the presence of the 2,2-bipyrimidine (bpym) ligand produced both a dinuclear and an octanuclear cation with the nuclearity being governed by hydrogen-bonding versus anion-pi interactions between the anions and the ligands.	Aligeron	60-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-31
31560017-1	2019	Self-assembly reactions of CoII ions in the presence of the 2,2-bipyrimidine (bpym) ligand produced both a dinuclear and an octanuclear cation with the nuclearity being governed by hydrogen-bonding versus anion-pi interactions between the anions and the ligands.	Aligeron	78-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-31
31560017-1	2019	Self-assembly reactions of CoII ions in the presence of the 2,2-bipyrimidine (bpym) ligand produced both a dinuclear and an octanuclear cation with the nuclearity being governed by hydrogen-bonding versus anion-pi interactions between the anions and the ligands.	Hydrogen	181-189	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-31
31687396-7	2019	Pyrene upregulated mRNA expression of phase I enzymes including CYP1A1, 1A2, and CYP1B1 and inflammatory markers including TNFalpha and Cox2.	pyrene	0-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	136-140
31555791-4	2019	The CoII ion exhibits a slightly distorted octahedral CoN3O3 coordination environment.	N-acetylchitooligosaccharide	54-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-8
31508635-3	2019	The reaction of Rad2 with the 3d transition metal complexes M(hfac)2 xH2O (hfac- = hexafluoroacetylacetonate) led to mononuclear metal complexes of general formula M(hfac)2(Rad2) [M = Zn(ii) (1); Ni(ii) (2) and Co(ii) (3)] whose structures have been determined by single crystal X-ray diffraction.	Metals	44-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	187-189
31555791-6	2019	The extracted D value is rather larger than those previously reported for the analogous CoIIYIII dinuclear complexes, which agrees with the fact that the CoII ion in the CoII2YIII2 complex exhibits a lower distortion from the octahedral geometry in this family of CoIInYIIIn complexes.	12-(4'-azido-2'-nitrophenoxy)dodecanoyl-coenzyme A	170-180	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-92
31508635-3	2019	The reaction of Rad2 with the 3d transition metal complexes M(hfac)2 xH2O (hfac- = hexafluoroacetylacetonate) led to mononuclear metal complexes of general formula M(hfac)2(Rad2) [M = Zn(ii) (1); Ni(ii) (2) and Co(ii) (3)] whose structures have been determined by single crystal X-ray diffraction.	Metals	44-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	199-201
31508635-3	2019	The reaction of Rad2 with the 3d transition metal complexes M(hfac)2 xH2O (hfac- = hexafluoroacetylacetonate) led to mononuclear metal complexes of general formula M(hfac)2(Rad2) [M = Zn(ii) (1); Ni(ii) (2) and Co(ii) (3)] whose structures have been determined by single crystal X-ray diffraction.	Metals	44-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	211-217
31420932-5	2019	The structures of Znby and of computationally generated Znbl were found to resemble the corresponding CoII -corrins, making such Zn-corrins potentially useful for investigations of B12 -dependent processes.	znby	18-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-106
31555791-6	2019	The extracted D value is rather larger than those previously reported for the analogous CoIIYIII dinuclear complexes, which agrees with the fact that the CoII ion in the CoII2YIII2 complex exhibits a lower distortion from the octahedral geometry in this family of CoIInYIIIn complexes.	12-(4'-azido-2'-nitrophenoxy)dodecanoyl-coenzyme A	264-274	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-92
31508635-3	2019	The reaction of Rad2 with the 3d transition metal complexes M(hfac)2 xH2O (hfac- = hexafluoroacetylacetonate) led to mononuclear metal complexes of general formula M(hfac)2(Rad2) [M = Zn(ii) (1); Ni(ii) (2) and Co(ii) (3)] whose structures have been determined by single crystal X-ray diffraction.	hexafluoroacetylacetonate	83-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	187-189
31228286-1	2019	A series of coordination compounds of redox-active 1,10-phenanthroline-5,6-diimine with CoII bis-diketonates and FeII dihydrobis(pyrazolyl)borates has been computationally designed by means of density functional theory (DFT UB3LYP*/6-311++G(d,p)) calculations of their electronic structure, energy characteristics, and magnetic properties.	1,10-phenanthroline-5,6-diimine	51-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-92
31508635-3	2019	The reaction of Rad2 with the 3d transition metal complexes M(hfac)2 xH2O (hfac- = hexafluoroacetylacetonate) led to mononuclear metal complexes of general formula M(hfac)2(Rad2) [M = Zn(ii) (1); Ni(ii) (2) and Co(ii) (3)] whose structures have been determined by single crystal X-ray diffraction.	hexafluoroacetylacetonate	83-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	199-201
31508635-3	2019	The reaction of Rad2 with the 3d transition metal complexes M(hfac)2 xH2O (hfac- = hexafluoroacetylacetonate) led to mononuclear metal complexes of general formula M(hfac)2(Rad2) [M = Zn(ii) (1); Ni(ii) (2) and Co(ii) (3)] whose structures have been determined by single crystal X-ray diffraction.	hexafluoroacetylacetonate	83-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	211-217
31508635-3	2019	The reaction of Rad2 with the 3d transition metal complexes M(hfac)2 xH2O (hfac- = hexafluoroacetylacetonate) led to mononuclear metal complexes of general formula M(hfac)2(Rad2) [M = Zn(ii) (1); Ni(ii) (2) and Co(ii) (3)] whose structures have been determined by single crystal X-ray diffraction.	Metals	129-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	187-189
31508635-3	2019	The reaction of Rad2 with the 3d transition metal complexes M(hfac)2 xH2O (hfac- = hexafluoroacetylacetonate) led to mononuclear metal complexes of general formula M(hfac)2(Rad2) [M = Zn(ii) (1); Ni(ii) (2) and Co(ii) (3)] whose structures have been determined by single crystal X-ray diffraction.	Metals	129-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	199-201
31508635-3	2019	The reaction of Rad2 with the 3d transition metal complexes M(hfac)2 xH2O (hfac- = hexafluoroacetylacetonate) led to mononuclear metal complexes of general formula M(hfac)2(Rad2) [M = Zn(ii) (1); Ni(ii) (2) and Co(ii) (3)] whose structures have been determined by single crystal X-ray diffraction.	Metals	129-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	211-217
31508635-5	2019	In the case of the Zn(ii) complex (1) through-space intermolecular radicalradical antiferromagnetic exchange interactions via pi*pi* contacts are observed, whereas strong intramolecular through-bond metal-radical ferromagnetic interactions [J = +59.3(9) cm-1] are observed for the Ni(ii) complex (2).	Metals	199-204	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-24
31508635-6	2019	For the Co(ii) complex (3), computational and magnetic studies reveal substantial zero field splitting and ferromagnetic metal-radical interactions.	Metals	121-126	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	8-14
31553166-1	2019	Two mononuclear tetrahedral Co(II) complexes (HNEt3)2[Co(L1)2] H2O (1) and (Bu4N)2[Co(L2)2] H2O (2) (H2L1 = N,N"-bis(p-toluenesulfony1)oxamide, H2L2 = N,N"-diphenyloxamide) have been synthesized, and their structures have been characterized by single-crystal X-ray diffraction.	Hydrogen Peroxide	45-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
31553166-2	2019	Both complexes adopt distorted tetrahedral coordination geometries surrounding the Co(II) center, which is ligated by two doubly deprotonated oxamide ligands oriented perpendicularly to each other.	oxamide	142-149	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
31420932-5	2019	The structures of Znby and of computationally generated Znbl were found to resemble the corresponding CoII -corrins, making such Zn-corrins potentially useful for investigations of B12 -dependent processes.	corrin	107-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-106
31420932-5	2019	The structures of Znby and of computationally generated Znbl were found to resemble the corresponding CoII -corrins, making such Zn-corrins potentially useful for investigations of B12 -dependent processes.	zn-corrins	129-139	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-106
31374529-1	2019	A new series of hybrid structures 14a-l containing thiohydantoin as anti-cancer moiety and pyrazole core possessing SO2Me pharmacophore as selective COX-2 moiety was designed and synthesized to be evaluated for both anti-inflammatory and anti-cancer activities.	pyrazole	91-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	149-154
31427145-0	2019	Synthesis, biological evaluation and molecular modeling of novel selective COX-2 inhibitors: sulfide, sulfoxide, and sulfone derivatives of 1,5-diarylpyrrol-3-substituted scaffold.	Sulfides	93-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
31427145-0	2019	Synthesis, biological evaluation and molecular modeling of novel selective COX-2 inhibitors: sulfide, sulfoxide, and sulfone derivatives of 1,5-diarylpyrrol-3-substituted scaffold.	sulfoxide	102-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
31427145-0	2019	Synthesis, biological evaluation and molecular modeling of novel selective COX-2 inhibitors: sulfide, sulfoxide, and sulfone derivatives of 1,5-diarylpyrrol-3-substituted scaffold.	Sulfones	117-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
31404794-0	2019	New phenolic cinnamic acid derivatives as selective COX-2 inhibitors.	cinnamic acid	13-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-57
31427145-0	2019	Synthesis, biological evaluation and molecular modeling of novel selective COX-2 inhibitors: sulfide, sulfoxide, and sulfone derivatives of 1,5-diarylpyrrol-3-substituted scaffold.	1,5-diarylpyrrol-3	140-158	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
31404794-3	2019	In this work, a new series of cinnamic acid derivatives, namely hexylamides, have been designed, synthesized and evaluated in human blood for their inhibitory activity of COX-1 and COX-2 enzymes.	cinnamic acid	30-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	181-186
31427145-3	2019	Results showed that the bioisosteric transformation of previously reported alkoxyethyl ethers (9a-c) into the corresponding alkyl thioethers (10a-c) still leads to selective and active compounds being the COX-2 inhibitory activity for most of them in the low nanomolar range.	alkoxyethyl ethers	75-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	205-210
31404794-3	2019	In this work, a new series of cinnamic acid derivatives, namely hexylamides, have been designed, synthesized and evaluated in human blood for their inhibitory activity of COX-1 and COX-2 enzymes.	caproamide	64-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	181-186
31427145-3	2019	Results showed that the bioisosteric transformation of previously reported alkoxyethyl ethers (9a-c) into the corresponding alkyl thioethers (10a-c) still leads to selective and active compounds being the COX-2 inhibitory activity for most of them in the low nanomolar range.	alkyl thioethers	124-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	205-210
31404794-4	2019	From this, new structure-activity relationships were built, showing that phenolic hydroxyl groups are essential for both COX-1 and COX-2 inhibition.	phenolic hydroxyl	73-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-136
31427145-4	2019	The oxidation products of 10a,b were also investigated and both couple of sulfoxides (11a,b) and sulfones (12a,b) showed an appreciable COX-2 inhibitory activity.	Sulfoxides	74-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	136-141
31427145-4	2019	The oxidation products of 10a,b were also investigated and both couple of sulfoxides (11a,b) and sulfones (12a,b) showed an appreciable COX-2 inhibitory activity.	Sulfones	97-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	136-141
31943931-3	2019	Here, a lyotropic liquid crystalline (LLC) templating method was employed to synthesize the first examples of LiMPO4 (LMP) of Mn(II), Co(II), and Ni(II).	2-(2-methylphenyl)oxirane	110-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-139
31588122-9	2019	A selective COX-2 inhibitor, celecoxib, enhanced the anti-tumoural efficacy of gemcitabine.	celecoxib	29-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-17
31588122-9	2019	A selective COX-2 inhibitor, celecoxib, enhanced the anti-tumoural efficacy of gemcitabine.	gemcitabine	79-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-17
31943931-3	2019	Here, a lyotropic liquid crystalline (LLC) templating method was employed to synthesize the first examples of LiMPO4 (LMP) of Mn(II), Co(II), and Ni(II).	2-(2-methylphenyl)oxirane	118-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-139
31943931-5	2019	The metal salts of Mn(II), Co(II) and Ni(II) produce MA-LMPs that crystallize into olivine structures by heat treatment of the LLC mesophase.	olivine	83-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-33
31486959-0	2019	Curcumin and capsaicin modulates LPS induced expression of COX-2, IL-6 and TGF-beta in human peripheral blood mononuclear cells.	Curcumin	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-64
31486959-0	2019	Curcumin and capsaicin modulates LPS induced expression of COX-2, IL-6 and TGF-beta in human peripheral blood mononuclear cells.	Capsaicin	13-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-64
31486959-2	2019	RT-PCR analysis has shown that the curcumin and capsaicin significantly reduced LPS induced over expression of COX-2, IL-6 and TGF-beta in PBMCs.	Curcumin	35-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	111-116
31486959-2	2019	RT-PCR analysis has shown that the curcumin and capsaicin significantly reduced LPS induced over expression of COX-2, IL-6 and TGF-beta in PBMCs.	Capsaicin	48-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	111-116
31486959-4	2019	Further, The docking of curcumin and capsaicin at the active pockets of COX-2, IL-6 and TGF-beta has shown - 3.90, - 4.49 and - 5.61 kcal/mol binding energy for curcumin and - 3.80, - 4.78 and - 5.76 kcal/mol binding energy for capsaicin, while multiple ligand simultaneous docking (MLSD) of both molecules has shown higher binding energy of - 4.24, - 5.35 and - 5.83 kcal/mol respectively.	Curcumin	24-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
31486959-4	2019	Further, The docking of curcumin and capsaicin at the active pockets of COX-2, IL-6 and TGF-beta has shown - 3.90, - 4.49 and - 5.61 kcal/mol binding energy for curcumin and - 3.80, - 4.78 and - 5.76 kcal/mol binding energy for capsaicin, while multiple ligand simultaneous docking (MLSD) of both molecules has shown higher binding energy of - 4.24, - 5.35 and - 5.83 kcal/mol respectively.	Capsaicin	37-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
31486959-4	2019	Further, The docking of curcumin and capsaicin at the active pockets of COX-2, IL-6 and TGF-beta has shown - 3.90, - 4.49 and - 5.61 kcal/mol binding energy for curcumin and - 3.80, - 4.78 and - 5.76 kcal/mol binding energy for capsaicin, while multiple ligand simultaneous docking (MLSD) of both molecules has shown higher binding energy of - 4.24, - 5.35 and - 5.83 kcal/mol respectively.	Curcumin	161-169	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
31486959-4	2019	Further, The docking of curcumin and capsaicin at the active pockets of COX-2, IL-6 and TGF-beta has shown - 3.90, - 4.49 and - 5.61 kcal/mol binding energy for curcumin and - 3.80, - 4.78 and - 5.76 kcal/mol binding energy for capsaicin, while multiple ligand simultaneous docking (MLSD) of both molecules has shown higher binding energy of - 4.24, - 5.35 and - 5.83 kcal/mol respectively.	Capsaicin	228-237	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
31336132-4	2019	Moreover, resveratrol increases nuclear inducible cyclooxygenase (COX)-2 accumulation, complexes with p53, and induces p53-dependent anti-proliferation.	Resveratrol	10-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-72
31590372-6	2019	For anti-inflammatory activity, S4 inhibited UVB-induced nitric oxide synthase (i-NOS) and cyclooxygenase (COX)-2 protein expression and inhibited nuclear factor-kappaB (NF-kB) translocation into the nucleus.	Sulfur	32-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-113
31336132-10	2019	T4 retained resveratrol-induced COX-2 in cytoplasm and prevented COX-2 nuclear accumulation when resveratrol treated cancer cells.	Resveratrol	12-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-37
31336132-10	2019	T4 retained resveratrol-induced COX-2 in cytoplasm and prevented COX-2 nuclear accumulation when resveratrol treated cancer cells.	Resveratrol	97-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-70
31336132-11	2019	A specific signal transducer and activator of transcription 3 (STAT3) inhibitor, S31-201, blocked T4-induced inhibition and restored resveratrol-induced nuclear COX-2 accumulation.	NSC 74859	81-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	161-166
31336132-11	2019	A specific signal transducer and activator of transcription 3 (STAT3) inhibitor, S31-201, blocked T4-induced inhibition and restored resveratrol-induced nuclear COX-2 accumulation.	Resveratrol	133-144	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	161-166
31336132-12	2019	By inhibiting the T4-activated STAT3 signal transduction axis with S31-201, resveratrol was able to sequentially reestablish COX-2/p53-dependent gene expressions and anti-proliferation.	Resveratrol	76-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-130
31339385-1	2019	Introduction: The cyclooxygenase (COX)-2 inhibitor celecoxib is an approved compound for rheumatoid (RA) and osteoarthritis (OA), combining both anti-inflammatory and analgesic properties with a good gastrointestinal tolerability.	Celecoxib	51-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-40
31350722-7	2019	Unexpectedly, collisional activation of the complex formed between the peptide and [CoIII(NH3)6]3+ induced gas-phase reduction of the metal to CoII, allowing the peptide to fragment via radical-based dissociation pathways.	Metals	134-139	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-88
31378107-0	2019	Regulation of YAP by Mammalian Target of Rapamycin Complex 1 in Endothelial Cells Controls Blood Pressure Through COX-2/mPGES-1/PGE2 Cascade.	Dinoprostone	128-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-119
31359509-3	2019	In O-demethylases, the oxidation to inactive [CoII ] is reversed by an ATP-dependent electron transfer catalyzed by the activating enzyme (AE).	Adenosine Triphosphate	71-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-50
31593087-5	2019	Cox proportional hazard regression analysis revealed the lower rate of admission for subjects under combination therapy (adjusted hazard ratio of 0.275; 95% confidence interval = 0.136-0.557, P < .001).Patients with RA and T2DM receiving the combination of COX-2 inhibitors and metformin were associated with lower admission rate than those on COX-2 inhibitors alone, and this effect may be attributed to the decrease in the levels of proinflammatory factors.	Metformin	278-287	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	257-262
31350224-9	2019	Interestingly, PGE2 secretion was more closely related to COX-1 expression than to COX-2 expression.	Dinoprostone	15-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
31100474-6	2019	Generation of PGE2 by action of cyclooxygenase (COX)-2 can promote growth and development, resistance to apoptosis, proliferation, invasion and metastasis, angiogenesis and drug resistance in colon cancer.	Dinoprostone	14-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-54
31100474-8	2019	It is suggested that there is a positive feedback loop between COX-2 and PGE2, in which function of COX-2 induces generation of PGE2, and upregulation of PGE2 increases the expression of COX-2 in colon cancer.	Dinoprostone	73-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-105
31100474-8	2019	It is suggested that there is a positive feedback loop between COX-2 and PGE2, in which function of COX-2 induces generation of PGE2, and upregulation of PGE2 increases the expression of COX-2 in colon cancer.	Dinoprostone	73-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-105
31100474-8	2019	It is suggested that there is a positive feedback loop between COX-2 and PGE2, in which function of COX-2 induces generation of PGE2, and upregulation of PGE2 increases the expression of COX-2 in colon cancer.	Dinoprostone	128-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-68
31100474-8	2019	It is suggested that there is a positive feedback loop between COX-2 and PGE2, in which function of COX-2 induces generation of PGE2, and upregulation of PGE2 increases the expression of COX-2 in colon cancer.	Dinoprostone	128-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-105
31100474-8	2019	It is suggested that there is a positive feedback loop between COX-2 and PGE2, in which function of COX-2 induces generation of PGE2, and upregulation of PGE2 increases the expression of COX-2 in colon cancer.	Dinoprostone	128-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-105
31723665-10	2019	In western blot analysis, co-treatment with remifentanil resulted in decreased phosphorylation of NF-kappaB, and expression of COX2 and PGE2 in LPS-induced inflammation, but the results were statistically significant only at low concentrations.	remifentanil	44-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	127-131
31136102-9	2019	MoTIFs PI for OS based on COX-2Tumor(T) &gt; 4, PD-1Stromal(S) &gt; 0, CD8S &lt; 1, and HLA-IS &lt; 1 was associated with worst survival (hazard ratio [HR] 2.50; 95% confidence interval [CI], 2.12-2.96; p &lt; 0.0001).	Osmium	14-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-31
31359509-5	2019	By applying europium(II)-diethylenetriaminepentaacetic acid (DTPA) as a reductant, we were able to determine the midpoint potential of the [CoII ]/[CoI ] couple of the protein-bound corrinoid cofactor in the absence and presence of AE and/or ATP.	europium(ii)-diethylenetriaminepentaacetic acid	12-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-144
31359509-5	2019	By applying europium(II)-diethylenetriaminepentaacetic acid (DTPA) as a reductant, we were able to determine the midpoint potential of the [CoII ]/[CoI ] couple of the protein-bound corrinoid cofactor in the absence and presence of AE and/or ATP.	Pentetic Acid	61-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-144
31359509-5	2019	By applying europium(II)-diethylenetriaminepentaacetic acid (DTPA) as a reductant, we were able to determine the midpoint potential of the [CoII ]/[CoI ] couple of the protein-bound corrinoid cofactor in the absence and presence of AE and/or ATP.	ae	232-234	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-144
31359509-5	2019	By applying europium(II)-diethylenetriaminepentaacetic acid (DTPA) as a reductant, we were able to determine the midpoint potential of the [CoII ]/[CoI ] couple of the protein-bound corrinoid cofactor in the absence and presence of AE and/or ATP.	Adenosine Triphosphate	242-245	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-144
31462037-3	2019	Heating CoCl2 in the presence of PyEtPDI afforded the six-coordinate Co(II) salt, [(PyEtPDI)CoCl][Cl].	cobaltous chloride	8-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-75
31462037-3	2019	Heating CoCl2 in the presence of PyEtPDI afforded the six-coordinate Co(II) salt, [(PyEtPDI)CoCl][Cl].	pyetpdi	33-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-75
31462037-3	2019	Heating CoCl2 in the presence of PyEtPDI afforded the six-coordinate Co(II) salt, [(PyEtPDI)CoCl][Cl].	[(pyetpdi)cocl]	82-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-75
31462037-4	2019	Upon adding 2 equiv of NaEt3BH, hydride transfer to one chelate imine functionality was observed, resulting in the formation of (kappa4-N,N,N,N-PyEtIPCHMeNEtPy)Co. Single-crystal X-ray diffraction and density functional theory calculations revealed that this compound possesses a low-spin Co(II) ground state featuring antiferromagnetic coupling to a singly reduced imino(pyridine) moiety.	naet3bh	23-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	289-295
31462037-4	2019	Upon adding 2 equiv of NaEt3BH, hydride transfer to one chelate imine functionality was observed, resulting in the formation of (kappa4-N,N,N,N-PyEtIPCHMeNEtPy)Co. Single-crystal X-ray diffraction and density functional theory calculations revealed that this compound possesses a low-spin Co(II) ground state featuring antiferromagnetic coupling to a singly reduced imino(pyridine) moiety.	Imines	64-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	289-295
31462037-4	2019	Upon adding 2 equiv of NaEt3BH, hydride transfer to one chelate imine functionality was observed, resulting in the formation of (kappa4-N,N,N,N-PyEtIPCHMeNEtPy)Co. Single-crystal X-ray diffraction and density functional theory calculations revealed that this compound possesses a low-spin Co(II) ground state featuring antiferromagnetic coupling to a singly reduced imino(pyridine) moiety.	imino	366-371	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	289-295
31462037-4	2019	Upon adding 2 equiv of NaEt3BH, hydride transfer to one chelate imine functionality was observed, resulting in the formation of (kappa4-N,N,N,N-PyEtIPCHMeNEtPy)Co. Single-crystal X-ray diffraction and density functional theory calculations revealed that this compound possesses a low-spin Co(II) ground state featuring antiferromagnetic coupling to a singly reduced imino(pyridine) moiety.	pyridine	372-380	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	289-295
31490500-3	2019	Covalent bond formation with the protein carboxylate was observed only with the NiII- and CoII-substituted POTs, following the HSAB concept and the principle of metal immobilization.	carboxylate	41-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-94
31490500-3	2019	Covalent bond formation with the protein carboxylate was observed only with the NiII- and CoII-substituted POTs, following the HSAB concept and the principle of metal immobilization.	hydroxysuccinimidyl-4-azidobenzoate	127-131	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-94
31432676-6	2019	Whereas for M = Ni (DeltaE = -13 kcal/mol) Ni+III is reduced to Ni+II, for M = Co, Fe, Mn (DeltaE = 1, 10, 6 kcal/mol, respectively) it is Co+III that is reduced to Co+II.	ni+iii	43-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-144
31454242-0	2019	Liquid-Phase Hydrogenation of Nitriles to Amines Facilitated by a Co(II)/Zn(0) Pair: A Ligand-Free Catalytic Protocol.	Nitriles	30-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-72
31454242-0	2019	Liquid-Phase Hydrogenation of Nitriles to Amines Facilitated by a Co(II)/Zn(0) Pair: A Ligand-Free Catalytic Protocol.	Amines	42-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-72
31432676-6	2019	Whereas for M = Ni (DeltaE = -13 kcal/mol) Ni+III is reduced to Ni+II, for M = Co, Fe, Mn (DeltaE = 1, 10, 6 kcal/mol, respectively) it is Co+III that is reduced to Co+II.	Cobalt	79-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-144
31432676-6	2019	Whereas for M = Ni (DeltaE = -13 kcal/mol) Ni+III is reduced to Ni+II, for M = Co, Fe, Mn (DeltaE = 1, 10, 6 kcal/mol, respectively) it is Co+III that is reduced to Co+II.	Iron	83-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-144
31293048-3	2019	One well-defined chiral CoII -complex is shown to be an efficient catalyst in the visible-light-induced conjugated addition of enones by alkyl and acyl radicals, providing synthetically valued chiral ketones and 1,4-dicarbonyls in 47-&gt;99 % yields with up to 97:3 e.r.	enones	127-133	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-28
31293048-3	2019	One well-defined chiral CoII -complex is shown to be an efficient catalyst in the visible-light-induced conjugated addition of enones by alkyl and acyl radicals, providing synthetically valued chiral ketones and 1,4-dicarbonyls in 47-&gt;99 % yields with up to 97:3 e.r.	alkyl and acyl radicals	137-160	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-28
31293048-3	2019	One well-defined chiral CoII -complex is shown to be an efficient catalyst in the visible-light-induced conjugated addition of enones by alkyl and acyl radicals, providing synthetically valued chiral ketones and 1,4-dicarbonyls in 47-&gt;99 % yields with up to 97:3 e.r.	Ketones	200-207	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-28
31293048-3	2019	One well-defined chiral CoII -complex is shown to be an efficient catalyst in the visible-light-induced conjugated addition of enones by alkyl and acyl radicals, providing synthetically valued chiral ketones and 1,4-dicarbonyls in 47-&gt;99 % yields with up to 97:3 e.r.	1,4-dicarbonyls	212-227	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-28
31317633-1	2019	Immobilization of planar CoII -2,3-naphthalocyanine (NapCo) complexes onto doped graphene resulted in a heterogeneous molecular Co electrocatalyst that was active and selective to reduce CO2 into CO in aqueous solution.	napco	53-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-29
31317633-1	2019	Immobilization of planar CoII -2,3-naphthalocyanine (NapCo) complexes onto doped graphene resulted in a heterogeneous molecular Co electrocatalyst that was active and selective to reduce CO2 into CO in aqueous solution.	Graphite	81-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-29
31317633-1	2019	Immobilization of planar CoII -2,3-naphthalocyanine (NapCo) complexes onto doped graphene resulted in a heterogeneous molecular Co electrocatalyst that was active and selective to reduce CO2 into CO in aqueous solution.	N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)-4-((4-fluorobenzyl)oxy)pyridine-2,6-dicarboxamide	187-190	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-29
31317633-1	2019	Immobilization of planar CoII -2,3-naphthalocyanine (NapCo) complexes onto doped graphene resulted in a heterogeneous molecular Co electrocatalyst that was active and selective to reduce CO2 into CO in aqueous solution.	Carbon Monoxide	187-189	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-29
31048000-14	2019	The COX-2 specific celecoxib was identified as the most potent drug to reduce IL-6, IL-8 and TNF-alpha formation after SM exposures in vitro.	Celecoxib	19-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
31393480-0	2019	Visible light-induced cytotoxicity studies on Co(ii) complexes having an anthracene-based curcuminoid ligand.	anthracene	73-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-52
31393480-0	2019	Visible light-induced cytotoxicity studies on Co(ii) complexes having an anthracene-based curcuminoid ligand.	curcuminoid	90-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-52
31393480-5	2019	The complexes displayed a quasi-reversible Co(i)/Co(ii) redox couple at ~-1.1 V and an irreversible Co(ii)/Co(iii) couple at ~1.3 V vs. Ag/AgCl in DMF-0.1 M [Bun4N](ClO4).	NAD	43-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-55
31393480-5	2019	The complexes displayed a quasi-reversible Co(i)/Co(ii) redox couple at ~-1.1 V and an irreversible Co(ii)/Co(iii) couple at ~1.3 V vs. Ag/AgCl in DMF-0.1 M [Bun4N](ClO4).	co(iii)	107-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-106
31393480-5	2019	The complexes displayed a quasi-reversible Co(i)/Co(ii) redox couple at ~-1.1 V and an irreversible Co(ii)/Co(iii) couple at ~1.3 V vs. Ag/AgCl in DMF-0.1 M [Bun4N](ClO4).	silver chloride	139-143	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-106
31393480-5	2019	The complexes displayed a quasi-reversible Co(i)/Co(ii) redox couple at ~-1.1 V and an irreversible Co(ii)/Co(iii) couple at ~1.3 V vs. Ag/AgCl in DMF-0.1 M [Bun4N](ClO4).	Dimethylformamide	147-150	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-55
31393480-5	2019	The complexes displayed a quasi-reversible Co(i)/Co(ii) redox couple at ~-1.1 V and an irreversible Co(ii)/Co(iii) couple at ~1.3 V vs. Ag/AgCl in DMF-0.1 M [Bun4N](ClO4).	Dimethylformamide	147-150	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-106
31521068-1	2019	Cobalt complexes that undergo charge-transfer induced spin-transitions or valence tautomerism from low spin CoIII to high spin (HS) CoII are potential candidates for magneto-optical switches.	Cobalt	0-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-112
31393480-5	2019	The complexes displayed a quasi-reversible Co(i)/Co(ii) redox couple at ~-1.1 V and an irreversible Co(ii)/Co(iii) couple at ~1.3 V vs. Ag/AgCl in DMF-0.1 M [Bun4N](ClO4).	bun4n	158-163	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-106
31521068-4	2019	Photoexcitation at 525 nm produces a low-spin CoII ligand-to-metal charge transfer state which undergoes intersystem crossing to high-spin CoII in 67 fs.	Metals	61-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-50
31393480-5	2019	The complexes displayed a quasi-reversible Co(i)/Co(ii) redox couple at ~-1.1 V and an irreversible Co(ii)/Co(iii) couple at ~1.3 V vs. Ag/AgCl in DMF-0.1 M [Bun4N](ClO4).	perchlorate	165-169	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-106
31521068-4	2019	Photoexcitation at 525 nm produces a low-spin CoII ligand-to-metal charge transfer state which undergoes intersystem crossing to high-spin CoII in 67 fs.	Metals	61-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-143
31393480-6	2019	Highly intense 9-accm ligand-centred bands were observed at ~250-450 nm, which masked the Co(ii)-based weak d-d bands in the DMF-Tris-HCl buffer (1 : 9 v/v).	dmf-tris-hcl	125-137	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-96
31347642-2	2019	The Ni(ii) complexes (Ni4Gd, Solv = MeOH; Ni4Dy, Solv = MeCN) are not SMMs in the absence of an applied dc field.	Methanol	36-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	7-9
31347642-2	2019	The Ni(ii) complexes (Ni4Gd, Solv = MeOH; Ni4Dy, Solv = MeCN) are not SMMs in the absence of an applied dc field.	ni4dy	42-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	7-9
31347642-2	2019	The Ni(ii) complexes (Ni4Gd, Solv = MeOH; Ni4Dy, Solv = MeCN) are not SMMs in the absence of an applied dc field.	acetonitrile	56-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	7-9
31398017-0	2019	Mechanistic Insight into Synergistic Catalysis of Olefin Hydrogenation by a Hetero-Dinuclear RuII-CoII Complex with Adjacent Reaction Sites.	Alkenes	50-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-102
31398017-2	2019	A synergistic effect between the adjacent RuII and CoII sites has been confirmed in catalytic olefin hydrogenation by the complex, exhibiting a much higher turnover number than those of mononuclear RuII or CoII complexes as the components.	Alkenes	94-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-55
31398017-2	2019	A synergistic effect between the adjacent RuII and CoII sites has been confirmed in catalytic olefin hydrogenation by the complex, exhibiting a much higher turnover number than those of mononuclear RuII or CoII complexes as the components.	Alkenes	94-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	206-210
31398017-3	2019	A RuII-hydrido species was detected by 1H NMR and electrospray ionization (ESI)-time-of-flight (TOF)-MS measurements as an intermediate to react with olefins, and CoII-bound methanol was suggested to act as a proton source.	Methanol	174-182	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	163-167
31022559-7	2019	However, in PIV3-infected epithelial cells celecoxib inhibited PGE2 release and COX-2 expression to significantly higher degree as compared to non-infected cells.	Celecoxib	43-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-85
31212177-0	2019	Design, synthesis of celecoxib-tolmetin drug hybrids as selective and potent COX-2 inhibitors.	Celecoxib	21-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-82
31212177-0	2019	Design, synthesis of celecoxib-tolmetin drug hybrids as selective and potent COX-2 inhibitors.	Tolmetin	31-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-82
31345747-0	2019	COX-1/COX-2 inhibition activities and molecular docking study of newly designed and synthesized pyrrolo[3,4-c]pyrrole Mannich bases.	pyrrolo[3,4-c]pyrrole mannich bases	96-131	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	6-11
31202132-0	2019	Carvacrol encapsulated nanocarrier/ nanoemulsion abrogates angiogenesis by downregulating COX-2, VEGF and CD31 in vitro and in vivo in a lung adenocarcinoma model.	carvacrol	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-95
31202132-9	2019	Our in-silico study also indicated the binding of carvacrol to COX-2 and VEGF at the active and allosteric sites of CD31 with low binding energy.	carvacrol	50-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-68
31464310-4	2019	In the present study, we identified that cyanidin treatment could strongly suppress the expression of NO, PGE2, TNF-alpha, IL-6, iNOs, COX-2, ADAMTS5 and MMP13, and reduce the degradation of aggrecan and collagen II in IL-1beta-induced human OA chondrocytes, indicating the anti-inflammatory effect of cyanidin.	cyanidin	41-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-140
31100474-8	2019	It is suggested that there is a positive feedback loop between COX-2 and PGE2, in which function of COX-2 induces generation of PGE2, and upregulation of PGE2 increases the expression of COX-2 in colon cancer.	Dinoprostone	128-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-68
31100474-8	2019	It is suggested that there is a positive feedback loop between COX-2 and PGE2, in which function of COX-2 induces generation of PGE2, and upregulation of PGE2 increases the expression of COX-2 in colon cancer.	Dinoprostone	128-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-105
31100474-8	2019	It is suggested that there is a positive feedback loop between COX-2 and PGE2, in which function of COX-2 induces generation of PGE2, and upregulation of PGE2 increases the expression of COX-2 in colon cancer.	Dinoprostone	128-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-105
31201908-7	2019	Experimentally, P(DADMAC-AAm)CMC/Fe2O3 and P(DADMAC-SA)CMC/Fe2O3 show high sorption capacity of Co(II), i.e. 69.67 mg g-1 and 75.17 mg g-1, respectively, which makes them potential sorbents for Co(II) removal from water/wastewater.	Iron(III) oxide	33-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-102
31201908-7	2019	Experimentally, P(DADMAC-AAm)CMC/Fe2O3 and P(DADMAC-SA)CMC/Fe2O3 show high sorption capacity of Co(II), i.e. 69.67 mg g-1 and 75.17 mg g-1, respectively, which makes them potential sorbents for Co(II) removal from water/wastewater.	Phosphorus	16-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-102
31201908-7	2019	Experimentally, P(DADMAC-AAm)CMC/Fe2O3 and P(DADMAC-SA)CMC/Fe2O3 show high sorption capacity of Co(II), i.e. 69.67 mg g-1 and 75.17 mg g-1, respectively, which makes them potential sorbents for Co(II) removal from water/wastewater.	Phosphorus	16-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	194-200
31201908-7	2019	Experimentally, P(DADMAC-AAm)CMC/Fe2O3 and P(DADMAC-SA)CMC/Fe2O3 show high sorption capacity of Co(II), i.e. 69.67 mg g-1 and 75.17 mg g-1, respectively, which makes them potential sorbents for Co(II) removal from water/wastewater.	dadmac-sa	45-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-102
31276975-4	2019	Then we validated our predictions of four candidate targets (IKK-beta, JNK, COX-2, MEK1) by performing docking studies with celastrol.	celastrol	124-133	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-81
31201908-7	2019	Experimentally, P(DADMAC-AAm)CMC/Fe2O3 and P(DADMAC-SA)CMC/Fe2O3 show high sorption capacity of Co(II), i.e. 69.67 mg g-1 and 75.17 mg g-1, respectively, which makes them potential sorbents for Co(II) removal from water/wastewater.	dadmac-sa	45-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	194-200
31201908-7	2019	Experimentally, P(DADMAC-AAm)CMC/Fe2O3 and P(DADMAC-SA)CMC/Fe2O3 show high sorption capacity of Co(II), i.e. 69.67 mg g-1 and 75.17 mg g-1, respectively, which makes them potential sorbents for Co(II) removal from water/wastewater.	cmc	29-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-102
31276975-5	2019	The results suggest that celastrol acts against rheumatoid arthritis by regulating the function of several signaling proteins, including MMP-9, COX-2, c-Myc, TGF-beta, c-JUN, JAK-1, JAK-3, IKK-beta, SYK, MMP-3, JNK and MEK1, which regulate the functions of Th1 and Th2 cells, macrophages, fibroblasts and endothelial cells in rheumatoid arthritis.	celastrol	25-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	144-149
31201908-7	2019	Experimentally, P(DADMAC-AAm)CMC/Fe2O3 and P(DADMAC-SA)CMC/Fe2O3 show high sorption capacity of Co(II), i.e. 69.67 mg g-1 and 75.17 mg g-1, respectively, which makes them potential sorbents for Co(II) removal from water/wastewater.	Iron(III) oxide	59-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-102
31201908-7	2019	Experimentally, P(DADMAC-AAm)CMC/Fe2O3 and P(DADMAC-SA)CMC/Fe2O3 show high sorption capacity of Co(II), i.e. 69.67 mg g-1 and 75.17 mg g-1, respectively, which makes them potential sorbents for Co(II) removal from water/wastewater.	Water	214-219	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-102
31021508-4	2019	An in silico study of agathisflavone against 17 essential proteins/enzymes revealed that inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 are the most efficient enzymes for the interaction and binding of this biflavonoid for its anti-inflammatory activity.	agathisflavone	22-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-154
31257475-4	2019	Ketamine treatment increased the binding of NF-kappaB and permissive histone H3 lysine-4 (H3K4)m3, but caused a decrease in the repressive histone H3K27m3 and H3K36m3 on the COX-2 promoter ranging from -1,522 to -1,331 bp as determined by a chromatin immunoprecipitation assay.	Ketamine	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	174-179
31257475-0	2019	Epigenetic regulation of COX-2 expression by DNA hypomethylation via NF-kappaB activation in ketamine-induced ulcerative cystitis.	Ketamine	93-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-30
31257475-1	2019	The present study investigated the methylation of CpG sites in the cyclooxygenase (COX)-2 promoter via nuclear factor (NF)-kappaB transcriptional regulation and elucidated its effect on the COX-2 transcriptional expression in a ketamine-induced ulcerative cystitis (KIC) animal model.	Ketamine	228-236	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-89
31257475-1	2019	The present study investigated the methylation of CpG sites in the cyclooxygenase (COX)-2 promoter via nuclear factor (NF)-kappaB transcriptional regulation and elucidated its effect on the COX-2 transcriptional expression in a ketamine-induced ulcerative cystitis (KIC) animal model.	Ketamine	228-236	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	190-195
31257475-2	2019	The results of the present study revealed that ketamine treatment induced NF-kappaB p65 translocation to nuclei and activated COX-2 expression and prostaglandin (PGE)2 production in bladder tissue, whereas COX-2 inhibitor suppressed the inflammatory effect.	Ketamine	47-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-131
31257475-2	2019	The results of the present study revealed that ketamine treatment induced NF-kappaB p65 translocation to nuclei and activated COX-2 expression and prostaglandin (PGE)2 production in bladder tissue, whereas COX-2 inhibitor suppressed the inflammatory effect.	Ketamine	47-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	206-211
31021508-4	2019	An in silico study of agathisflavone against 17 essential proteins/enzymes revealed that inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 are the most efficient enzymes for the interaction and binding of this biflavonoid for its anti-inflammatory activity.	Biflavonoids	226-237	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-154
31095963-6	2019	However, if administered at termination of convulsions, the NSAID ibuprofen, the selective COX 2 inhibitor nimesulide and the PLA2 inhibitor quinacrine were partially effective in reducing brain inflammatory markers.	nimesulide	107-117	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-96
31480533-9	2019	The produced EGCG microparticles reduced the expression of inflammatory (IL-6, IL-8, COX-2) and catabolic (MMP1, MMP3, MMP13) mediators in pro-inflammatory 3D cell cultures.	epigallocatechin gallate	13-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-90
31480263-5	2019	Moreover, cyclooxygenase-1 (COX-1) activity was enhanced only in Ps, but cyclooxygenase-2 (COX-2) was enhanced both in Ps and PsA, generating higher levels of eicosanoids: prostaglandin E1 (PGE1), leukotriene B4 (LTB4), 13-hydroxyoctadecadienoic acid (13HODE), thromboxane B2 (TXB2).	Eicosanoids	159-170	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-96
31339119-6	2019	Interestingly, the Co(ii)/Co(iii) mixed-valence complex 6 resulted from the treatment of 1 with silver perchlorate (1.0 equiv.)	co(iii)	26-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-25
31339119-6	2019	Interestingly, the Co(ii)/Co(iii) mixed-valence complex 6 resulted from the treatment of 1 with silver perchlorate (1.0 equiv.)	silver perchlorate	96-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-25
31453072-0	2019	Erratum: Co (II) Boron Imidazolate Framework with Rigid Auxiliary Linkers for Stable Electrocatalytic Oxygen Evolution Reaction.	Oxygen	102-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	9-15
30892897-1	2019	The transition metal-substituted Krebs-type polyoxometalates (POMs) [Sb2W20M2O70(H2O)6]n-, M = Fe(III), Co(II), or Cu(II), were surface immobilized within the conducting polymer 3,4-ethylenedioxythiophene (PEDOT) on glassy carbon electrode surfaces.	polyoxometalate I	44-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-110
30892897-3	2019	The inherent redox activity for the Krebs-type POMs, [Sb2W20M2O70(H2O)6]n-, M = Fe(III), Co(II), or Cu(II), that were observed in the solution phase were maintained in the polymeric PEDOT matrix.	krebs	36-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-95
30892897-3	2019	The inherent redox activity for the Krebs-type POMs, [Sb2W20M2O70(H2O)6]n-, M = Fe(III), Co(II), or Cu(II), that were observed in the solution phase were maintained in the polymeric PEDOT matrix.	[sb2w20m2o70	53-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-95
31434303-7	2019	The method was then applied to the fabrication of a heavy metal adsorbent that possessed a sufficient adsorption capacity of Co(II) ions.	Metals	58-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-131
31132359-4	2019	And structure characteristics of flavonoids for COX-2 inhibition were mainly analyzed by a quantitative structure activity relationship (QSAR) model.	Flavonoids	33-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-53
31412584-5	2019	In addition, docetaxel and radiation decrease aromatase activity and expression by decreasing aromatase promoter II and cyclooxygenases 1 and 2 (COX-1 and COX-2) expression.	Docetaxel	13-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	155-160
31412584-8	2019	Melatonin also potentiates the inhibitory effect exerted by radiation on aromatase activity and expression by increasing the downregulation of promoter II, and COX-1 and COX-2 expression.	Melatonin	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	170-175
31534549-10	2019	We retrospectively analyzed the 5mC content of 42 patients with intestinal metaplasia (a precancerous lesion of GC) treated with a COX-2 specific inhibitor Rofecoxib or placebo for 2 years, revealing that the COX-2 inhibitor significantly down-regulated 5mC levels (N=42, P=0.009).	rofecoxib	156-165	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-136
31398912-7	2019	In addition, 5-7HP inhibited PM-induced ROS generation and then downregulated ROS-mediated COX-2 and MMP9 production and AQP-3 consumption by inhibiting the phosphorylation of MAPKs.	5-7hp	13-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-96
31398912-7	2019	In addition, 5-7HP inhibited PM-induced ROS generation and then downregulated ROS-mediated COX-2 and MMP9 production and AQP-3 consumption by inhibiting the phosphorylation of MAPKs.	ros	78-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-96
31132359-10	2019	It indicated that flavanones such as hesperetin, naringenin, liquiritigenin were efficient to repress COX-2 mRNA and they were potential anti-inflammatory natural products.	hesperetin	37-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-107
31283191-1	2019	The slow magnetic relaxation of CoII ions in the elusive intermediate geometry between the trigonal prism and antiprism has been studied on the new [Co2L3]4+ and [CoZnL3]4+ coordination helicates [L is a bis(pyrazolylpyridine) ligand].	co2l3	149-154	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-36
31283191-1	2019	The slow magnetic relaxation of CoII ions in the elusive intermediate geometry between the trigonal prism and antiprism has been studied on the new [Co2L3]4+ and [CoZnL3]4+ coordination helicates [L is a bis(pyrazolylpyridine) ligand].	bis(pyrazolylpyridine)	204-226	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-36
31132359-10	2019	It indicated that flavanones such as hesperetin, naringenin, liquiritigenin were efficient to repress COX-2 mRNA and they were potential anti-inflammatory natural products.	naringenin	49-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-107
31132359-10	2019	It indicated that flavanones such as hesperetin, naringenin, liquiritigenin were efficient to repress COX-2 mRNA and they were potential anti-inflammatory natural products.	liquiritigenin	61-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-107
31132359-11	2019	Further, substitution with a glucopyranosyl at C-6 resulted in a poorer molecule balance than that at C-8 and a lower COX-2 mRNA inhibiton accordingly.	glucopyranosyl	29-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-123
31035130-5	2019	Furthermore, the influence of bivalent metal ions on the binding affinity was resulted in order of Cu(II) &gt; Ca(II) &gt; Co(II) &gt; Zn(II).	Metals	39-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-129
31132359-13	2019	Also, methoxyl groups at C-4" may also be a favorable flavonoid structural characteristic for COX-2 mRNA inhibiton.	Flavonoids	54-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-99
31035130-5	2019	Furthermore, the influence of bivalent metal ions on the binding affinity was resulted in order of Cu(II) &gt; Ca(II) &gt; Co(II) &gt; Zn(II).	cu(ii)	99-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-129
31310134-4	2019	Mechanistic studies suggest that the reaction proceeds through a different mechanism from that of our previously reported transformation in which a Co(II) catalyst/8-amino-5-choloroquinoline chelation system was used.	8-amino-5-choloroquinoline	164-190	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	148-154
31035130-5	2019	Furthermore, the influence of bivalent metal ions on the binding affinity was resulted in order of Cu(II) &gt; Ca(II) &gt; Co(II) &gt; Zn(II).	Zinc	135-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-129
30334373-0	2019	Euxanthone Impairs the Metastatic Potential of Osteosarcoma by Reducing COX-2 Expression.	euxanthone	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
31380790-0	2019	Two CoII coordination polymers of biphenyl-2,2",5,5"-tetracarboxylic acid with flexible N-donor ligands: syntheses, structures and magnetic properties.	biphenyl-2,2",5,5"-tetracarboxylic acid	34-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-8
31380790-0	2019	Two CoII coordination polymers of biphenyl-2,2",5,5"-tetracarboxylic acid with flexible N-donor ligands: syntheses, structures and magnetic properties.	Nitrogen	88-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-8
31380790-3	2019	The bridging (o,m-bpta)4- ligands combine with CoII ions in different mu4-coordination modes, leading to the formation of one-dimensional chains.	(o,m-bpta	13-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-51
31380790-5	2019	The bis[(1H-imidazol-1-yl)methyl]benzene (bimb) ligands adopt trans or cis conformations to connect CoII ions, thus forming two three-dimensional (3D) networks.	bis[(1h-imidazol-1-yl)methyl]benzene	4-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-104
31380790-5	2019	The bis[(1H-imidazol-1-yl)methyl]benzene (bimb) ligands adopt trans or cis conformations to connect CoII ions, thus forming two three-dimensional (3D) networks.	bimb	42-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-104
30334373-4	2019	COX-2-over-expressing plasmid was applied to transfect OS cells to assess whether COX-2 affects the anti-metastatic function of euxanthone.	euxanthone	128-138	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
30334373-9	2019	Our experimental data also showed that repression of COX-2 by euxanthone mediated its anti-metastatic activities.	euxanthone	62-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-58
30334373-10	2019	Moreover, our findings revealed that euxanthone modulated the COX-2 expression through the miR-21/PDCD4/c-jun signaling pathway.	euxanthone	37-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
31240657-0	2019	Efficient abatement of an iodinated X-ray contrast media iohexol by Co(II) or Cu(II) activated sulfite autoxidation process.	Iohexol	57-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-74
31160177-0	2019	Chalcone derivatives bearing chromen or benzo[f]chromen moieties: Design, synthesis, and evaluations of anti-inflammatory, analgesic, selective COX-2 inhibitory activities.	Chalcone	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	144-149
31160177-5	2019	Six compounds bearing a chromen moiety were weak inhibitors of the COX-1 isozyme but showed moderate COX-2 isozyme inhibitory effects (IC50s from 0.37 muM to 0.83 muM) and COX-2 selectivity indexes (SI: 22.49-9.34).	chromen	24-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-106
31160177-5	2019	Six compounds bearing a chromen moiety were weak inhibitors of the COX-1 isozyme but showed moderate COX-2 isozyme inhibitory effects (IC50s from 0.37 muM to 0.83 muM) and COX-2 selectivity indexes (SI: 22.49-9.34).	chromen	24-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	172-177
31160177-6	2019	Those bearing a benzo[f]chromen moiety were more selective toward COX-2 than those bearing a chromen moiety with IC50s from 0.25 muM to 0.43 muM and COX-2 selectivity indexes from SI: 31.08 to 20.67.	benzo[f]chromen	16-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-71
31160177-6	2019	Those bearing a benzo[f]chromen moiety were more selective toward COX-2 than those bearing a chromen moiety with IC50s from 0.25 muM to 0.43 muM and COX-2 selectivity indexes from SI: 31.08 to 20.67.	benzo[f]chromen	16-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	149-154
31240657-0	2019	Efficient abatement of an iodinated X-ray contrast media iohexol by Co(II) or Cu(II) activated sulfite autoxidation process.	Sulfites	95-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-74
31240657-7	2019	Overall, activation of sulfite to produce reactive radicals with extremely low Co(II) or Cu(II) concentrations (in the range of mug L-1) in circumneutral conditions is confirmed, which offers a potential SO4 --based advanced oxidation process in treatment of aquatic organic contaminants.	Sulfites	23-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-85
31005060-9	2019	CONCLUSIONS:  Aspirin 15 cH acts through the inhibition of the COX-2 pathway producing a clear pro-thrombotic effect.	Aspirin	14-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-68
30623450-10	2019	Furthermore, curcumin has a potent inhibitory effect on the activity of NF-kappaB and COX-2, which are involved in the overexpression of antiapoptosis genes such as Bcl-2.	Curcumin	13-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-91
30885661-3	2019	In this work, IBU is dissolved in methanol and then treated with a Co(II) aqueous solution, forming a blue complex which is extractable by dispersive liquid-liquid microextraction.	Ibuprofen	14-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-73
30913819-4	2019	The presence of Zn(II) metal ion is determined through the band at 150 cm-1 (T2g(1) phonon mode), which is not present in the pure Co-ferrite, a blue-shift of the Eg vibrational mode depending on Zn(II)/Co(II) cationic distribution and a shoulder at ~250 cm-1, which appears when zinc enters in the structure, and a broadening and a red-shift in the A1g phonon mode is observed in Raman spectra of 2-4 samples.	Zinc	16-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	203-209
30913819-4	2019	The presence of Zn(II) metal ion is determined through the band at 150 cm-1 (T2g(1) phonon mode), which is not present in the pure Co-ferrite, a blue-shift of the Eg vibrational mode depending on Zn(II)/Co(II) cationic distribution and a shoulder at ~250 cm-1, which appears when zinc enters in the structure, and a broadening and a red-shift in the A1g phonon mode is observed in Raman spectra of 2-4 samples.	Metals	23-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	203-209
30885661-3	2019	In this work, IBU is dissolved in methanol and then treated with a Co(II) aqueous solution, forming a blue complex which is extractable by dispersive liquid-liquid microextraction.	Methanol	34-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-73
31423209-13	2019	In summary, the results indicate that activation of the COX-2-PGE2 pathway in RCC leads to the development of sunitinib resistance and may serve an important role in the maintenance of the characteristics of stem cells that are closely associated with drug resistance.	Sunitinib	110-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-66
31265312-1	2019	Various architectures have been generated and observed by STM at a solid/liquid interface resulting from an in situ chemical reaction between the bipyridine terminal groups of a ditopic ligand and Co(II) ions.	2,2'-Dipyridyl	146-156	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	197-203
31265312-2	2019	Large monodomains of one-dimensional (1D) double wires are formed by Co(II)/ligand coordination, with polymer lengths as long as 150 nm.	Polymers	102-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-75
31343981-7	2019	Treatment of cells with EAE or EA showed upregulation of mRNA expression of the antioxidative gene superoxide dismutase (SOD)-2 and downregulated the expression of inducible nitric oxide synthase (iNOS), soluble cell adhesion molecule (sICAM), and cyclooxygenase (COX)-2.	EAE	24-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	248-270
31343981-7	2019	Treatment of cells with EAE or EA showed upregulation of mRNA expression of the antioxidative gene superoxide dismutase (SOD)-2 and downregulated the expression of inducible nitric oxide synthase (iNOS), soluble cell adhesion molecule (sICAM), and cyclooxygenase (COX)-2.	Ellagic Acid	24-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	248-270
31696069-2	2019	The induction enzyme of cyclooxygenase COX-2 causes biosynthesis of prostaglandin and thromboxane during inflammation of the body.	Prostaglandins	68-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-44
31696069-2	2019	The induction enzyme of cyclooxygenase COX-2 causes biosynthesis of prostaglandin and thromboxane during inflammation of the body.	Thromboxanes	86-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-44
31380437-0	2019	Cox-2 Negatively Affects the Protective Role of Propofol against Hypoxia/Reoxygenation Induced Cardiomyocytes Apoptosis through Suppressing Akt Signaling.	Propofol	48-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
31331008-8	2019	In human hepatocellular carcinoma HepG2 cells, melatonin suppressed p21 along with the induction of pro-survival proteins, PI3K and COX-2.	Melatonin	47-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-137
31331008-9	2019	However, EGCG prevented against melatonin-induced PI3K and COX-2, and melatonin probably sensitized HepG2 cells to EGCG cytotoxicity via down-regulating p21, Moreover, COX-2 and HO-1 were significantly reduced only by the co-treatment, and melatonin aided EGCG to achieve an increased inhibition on Bcl2 and NFkappaB.	epigallocatechin gallate	9-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-64
31331008-9	2019	However, EGCG prevented against melatonin-induced PI3K and COX-2, and melatonin probably sensitized HepG2 cells to EGCG cytotoxicity via down-regulating p21, Moreover, COX-2 and HO-1 were significantly reduced only by the co-treatment, and melatonin aided EGCG to achieve an increased inhibition on Bcl2 and NFkappaB.	Melatonin	32-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-64
31276126-0	2019	Co(ii)/Cu(ii)-cocatalyzed oxidative C-H/N-H functionalization of benzamides with ketones: a facile route to isoindolin-1-ones.	Benzamides	65-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
31276126-0	2019	Co(ii)/Cu(ii)-cocatalyzed oxidative C-H/N-H functionalization of benzamides with ketones: a facile route to isoindolin-1-ones.	Benzamides	65-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	3-5
31276126-0	2019	Co(ii)/Cu(ii)-cocatalyzed oxidative C-H/N-H functionalization of benzamides with ketones: a facile route to isoindolin-1-ones.	Ketones	81-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
31276126-0	2019	Co(ii)/Cu(ii)-cocatalyzed oxidative C-H/N-H functionalization of benzamides with ketones: a facile route to isoindolin-1-ones.	Ketones	81-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	3-5
31276126-0	2019	Co(ii)/Cu(ii)-cocatalyzed oxidative C-H/N-H functionalization of benzamides with ketones: a facile route to isoindolin-1-ones.	isoindolin-1-ones	108-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
31276126-0	2019	Co(ii)/Cu(ii)-cocatalyzed oxidative C-H/N-H functionalization of benzamides with ketones: a facile route to isoindolin-1-ones.	isoindolin-1-ones	108-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	3-5
31317334-2	2019	As inhalation of heavy metal ions like cobalt can lead to lung cancer, a fluorescent probe was designed for the determination of Co(II) both in aqueous solutions and living cells.	Metals	23-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-135
31317334-2	2019	As inhalation of heavy metal ions like cobalt can lead to lung cancer, a fluorescent probe was designed for the determination of Co(II) both in aqueous solutions and living cells.	Cobalt	39-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-135
31231741-0	2019	Structural and magnetic characterization of Ni(ii), Co(ii), and Fe(ii) binuclear complexes on a bis(pyridyl-triazolyl)alkane basis.	bis(pyridyl-triazolyl)alkane	96-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-49
31231741-0	2019	Structural and magnetic characterization of Ni(ii), Co(ii), and Fe(ii) binuclear complexes on a bis(pyridyl-triazolyl)alkane basis.	bis(pyridyl-triazolyl)alkane	96-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-57
31380437-6	2019	We also revealed that treatment of propofol suppressed the expression of Cox-2 in cardiomyocytes which was up-regulated after H/R treatment.	Propofol	35-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-78
31380437-9	2019	Thus, it could be concluded that Cox-2 negatively affects the protective effect of propofol against hypoxia/reoxygenation induced cardiomyocyte apoptosis by suppressing Akt phosphorylation.	Propofol	83-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-38
31246209-4	2019	According to the structural and spectroscopy data along with magnetic susceptibility measurements the electronic structure of the complexes should be interpreted definitely as a high spin metal center NiII (d8, S = 1) in 1 and CoII (d7, S = 3/2) in 2 bonded with two o-iminobenzosemiquinonate radicals (Srad = 1/2).	o-iminobenzosemiquinonate radicals	267-301	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	227-231
31247812-4	2019	Electrochemical as well as spectroscopic investigations in CH3CN coupled to density functional theory (DFT) calculations point to decoordination of one of the amine upon reduction of Co(II) to the low-valent "Co(I)" form.	Amines	159-164	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	183-189
31247812-4	2019	Electrochemical as well as spectroscopic investigations in CH3CN coupled to density functional theory (DFT) calculations point to decoordination of one of the amine upon reduction of Co(II) to the low-valent "Co(I)" form.	NAD	209-214	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	183-189
31308445-11	2019	For the first time, we report the ability of NAM to augment PARP1 activation, induced by RSV, and its associated anti-inflammatory effects mediated through the induction of BCL6 with the concomitant down regulation of COX-2.	Niacinamide	45-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	218-223
31005705-1	2019	An efficient method for the consolidation of cobalt (Co(II)) adsorbed calcium hydroxyapatite was investigated to develop a simplified route for decontamination of the coolant system of nuclear power plants and direct immobilization of as-spent adsorbent.	Cobalt	45-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-59
31005705-1	2019	An efficient method for the consolidation of cobalt (Co(II)) adsorbed calcium hydroxyapatite was investigated to develop a simplified route for decontamination of the coolant system of nuclear power plants and direct immobilization of as-spent adsorbent.	Durapatite	70-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-59
31005705-2	2019	Calcium hydroxyapatite nano-powder synthesized by a wet precipitation method was used as an adsorbent and 94% Co(II) surrogate removal from simulated water was measured.	Durapatite	0-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-115
31189315-3	2019	First, a homo-tetranuclear CoII4 complex was converted to a mixed-valence CoIIICoII3 complex by site-selective oxidation, which was then transmetalated from CoII to NiII to form a heterometallic CoIIINiII3 complex.	coiiicoii3	74-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-31
31336734-1	2019	Celecoxib (CLX), a selective COX-2 inhibitor, is a biopharmaceutics classification system (BCS) class II drug with its bioavailability being limited by thepoor aqueoussolubility.	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34
31336734-1	2019	Celecoxib (CLX), a selective COX-2 inhibitor, is a biopharmaceutics classification system (BCS) class II drug with its bioavailability being limited by thepoor aqueoussolubility.	Celecoxib	11-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34
31278366-11	2019	In conclusion, Co(II) and Cu(II) metal complexes bearing two imidazole-4-acetate ligands seemed to be promising antitumor and antifungal agents for future drug design and application.	imidazole	61-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-21
31278366-11	2019	In conclusion, Co(II) and Cu(II) metal complexes bearing two imidazole-4-acetate ligands seemed to be promising antitumor and antifungal agents for future drug design and application.	4-acetate	71-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-21
31189315-3	2019	First, a homo-tetranuclear CoII4 complex was converted to a mixed-valence CoIIICoII3 complex by site-selective oxidation, which was then transmetalated from CoII to NiII to form a heterometallic CoIIINiII3 complex.	coiiiniii3	195-205	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-31
31270632-12	2019	Graphical abstract Schematic presentation of the quenching of the fluorescence of phosphorus and nitrogen dually-doped carbon quantum dots (PN-CQDs) by vitamin B12 (VB12) and Co(II).	Phosphorus	82-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	175-181
31270632-12	2019	Graphical abstract Schematic presentation of the quenching of the fluorescence of phosphorus and nitrogen dually-doped carbon quantum dots (PN-CQDs) by vitamin B12 (VB12) and Co(II).	Nitrogen	97-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	175-181
31270632-12	2019	Graphical abstract Schematic presentation of the quenching of the fluorescence of phosphorus and nitrogen dually-doped carbon quantum dots (PN-CQDs) by vitamin B12 (VB12) and Co(II).	Carbon	119-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	175-181
31075742-5	2019	Moreover, the target derivatives 9a-l demonstrated moderate to high potent inhibitory action towards COX-2 (IC50 = 0.87-3.78 microM), in particular, the derivatives 9e (IC50 = 0.92 microM), 9g (IC50 = 0.87 microM) and 9k (IC50 = 1.02 microM) recorded higher COX-2 inhibitory effect than the selective COX-2 inhibitor drug celecoxib (IC50 = 1.11 microM).	Celecoxib	322-331	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-106
31235242-2	2019	The cause of AERD have remained unclear, however the decrease in the production of PGE2 caused by the reduction in COX-2 activity is considered to main pathological mechanism of AERD.	Dinoprostone	83-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-120
30797367-2	2019	Twenty-five stilbenoids were screened in vitro for their ability to inhibit COX-1, COX-2 and 5-LOX.	stilbenoids	12-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-94
31248835-11	2019	NF-kappaB signalling pathway mediated the activation of COX2/PGE2 in AC-MSCs.	Dinoprostone	61-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-60
30953868-8	2019	This study indicated that COX-2 may be involved in pathogenesis of ASD and/or allergy, and osthole could be used to decrease the effects of COX-2 in inflammation and ASD development.	osthol	91-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-145
30953868-10	2019	CONCLUSIONS: This study shows that fexofenadine (FXF - antihistamine drug) and osthole exhibit selective COX-2 enzyme inhibitory activity.	fexofenadine	35-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-110
30953868-10	2019	CONCLUSIONS: This study shows that fexofenadine (FXF - antihistamine drug) and osthole exhibit selective COX-2 enzyme inhibitory activity.	osthol	79-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-110
30953868-11	2019	The selective COX-2 activity of osthole may explain further the anti-inflammatory properties of osthole in relieving congestion in allergic rhinitis, and as distinctive effects between FXF and osthole were observed, individual antihistamines may have different modes of action via the COX enzyme system.	osthol	32-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
30975331-0	2019	Effect of Co(II) dopant on the removal of Methylene Blue by a dense copper terephthalate.	Methylene Blue	42-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-16
31247845-0	2019	Exploring Inner-Sphere Water Interactions of Fe(II) and Co(II) Complexes of 12-Membered Macrocycles To Develop CEST MRI Probes.	Water	23-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-62
31247845-1	2019	Several paramagnetic Co(II) and Fe(II) macrocyclic complexes were prepared with the goal of introducing a bound water ligand to produce paramagnetically shifted water 1H resonances and for paramagnetic chemical exchange saturation transfer (paraCEST) applications.	Water	112-117	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-27
31247845-1	2019	Several paramagnetic Co(II) and Fe(II) macrocyclic complexes were prepared with the goal of introducing a bound water ligand to produce paramagnetically shifted water 1H resonances and for paramagnetic chemical exchange saturation transfer (paraCEST) applications.	Water	161-166	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-27
31247845-1	2019	Several paramagnetic Co(II) and Fe(II) macrocyclic complexes were prepared with the goal of introducing a bound water ligand to produce paramagnetically shifted water 1H resonances and for paramagnetic chemical exchange saturation transfer (paraCEST) applications.	Hydrogen	167-169	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-27
31247845-3	2019	The crystal structure of [Co(DCMC)]Br2 featured a six-coordinated Co(II) center with distorted octahedral geometry, while [Co(NODA)(OH2)]Cl2 and [Co(N3OA)](NO3)2 were seven-coordinated.	co(dcmc)	26-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-72
31247845-8	2019	Variable-temperature 17O NMR spectra of Co(II) and Fe(II) NODA complexes were consistent with rapid exchange of the water ligand with bulk water.	17o	21-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-46
31247845-8	2019	Variable-temperature 17O NMR spectra of Co(II) and Fe(II) NODA complexes were consistent with rapid exchange of the water ligand with bulk water.	Water	116-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-46
31247845-8	2019	Variable-temperature 17O NMR spectra of Co(II) and Fe(II) NODA complexes were consistent with rapid exchange of the water ligand with bulk water.	Water	139-144	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-46
31247845-9	2019	Notably, the Co(II) and Fe(II) complexes presented here produced substantial paramagnetic shifts of bulk water 1H resonances, independent of having an inner-sphere water.	Water	105-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-19
31247845-9	2019	Notably, the Co(II) and Fe(II) complexes presented here produced substantial paramagnetic shifts of bulk water 1H resonances, independent of having an inner-sphere water.	Hydrogen	111-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-19
31247845-9	2019	Notably, the Co(II) and Fe(II) complexes presented here produced substantial paramagnetic shifts of bulk water 1H resonances, independent of having an inner-sphere water.	Water	164-169	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-19
30035675-0	2019	Docking-based 3D-QSAR (CoMFA, CoMFA-RG, CoMSIA) study on hydroquinoline and thiazinan-4-one derivatives as selective COX-2 inhibitors.	quinoline	57-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-122
30035675-0	2019	Docking-based 3D-QSAR (CoMFA, CoMFA-RG, CoMSIA) study on hydroquinoline and thiazinan-4-one derivatives as selective COX-2 inhibitors.	4-oxothiazan	76-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-122
30975331-0	2019	Effect of Co(II) dopant on the removal of Methylene Blue by a dense copper terephthalate.	Copper terephthalate	68-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-16
30975331-1	2019	In this research, for the first time, a series of Co(II) doped copper terephthalate (CoX-CuBDC, where X is doping percentage) were successfully synthesized via solvothermal method and were tested for dye removal application.	Copper terephthalate	63-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-56
30975331-3	2019	The incorporation of Co(II) dopant leads to isomorphic substitution of Cu(II) in the CuBDC framework with the maximum doping percentage of 22.	cu(ii)	71-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-27
31277138-16	2019	CONCLUSION: Celecoxib combined with chemotherapy offers more clinical benefits for COX-2 positive advanced gastric cancer patients.	Celecoxib	12-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
31115540-5	2019	Increased levels of proinflammatory cytokines TNF-alpha, COX-2, IL-6 and IL-1beta following UVB exposure were suppressed by the introduction of DCEQA.	dceqa	144-149	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-62
31288897-7	2019	Blocking PI3K signaling abolished the inhibitory effect of 1,25(OH)2D3 on LPS-induced increase of Akt S473 phosphorylation and COX-2 expression.	Calcitriol	59-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	127-132
31288897-8	2019	Blocking NF-kappaB signaling blunted the suppression effect of 1,25(OH)2D3 on IkappaBalpha phosphorylation, NF-kappaB accumulation in the nucleus and COX-2 expression.	Calcitriol	63-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	150-155
31341381-7	2019	Results: Extracellular hyperosmolarity induced a dose-dependent increase in COX2 gene expression when &gt;10 mM NaCl was added to the culture medium, while COX1 gene expression was increased at higher doses (&gt;50 mM of added NaCl).	Sodium Chloride	112-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-80
30663092-4	2019	So the radiosynthesis of a fluorine-18-labelled COX-2 inhibitor [18 F]1b, a close derivative of valdecoxib, was performed with 18 FBIC and 1-ethynyl-4-(methylsulfonyl)benzene, providing [18 F]1b in up to 40% RCY after purification in 85 minutes.	Fluorine-18	27-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-53
30663092-4	2019	So the radiosynthesis of a fluorine-18-labelled COX-2 inhibitor [18 F]1b, a close derivative of valdecoxib, was performed with 18 FBIC and 1-ethynyl-4-(methylsulfonyl)benzene, providing [18 F]1b in up to 40% RCY after purification in 85 minutes.	valdecoxib	96-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-53
30663092-4	2019	So the radiosynthesis of a fluorine-18-labelled COX-2 inhibitor [18 F]1b, a close derivative of valdecoxib, was performed with 18 FBIC and 1-ethynyl-4-(methylsulfonyl)benzene, providing [18 F]1b in up to 40% RCY after purification in 85 minutes.	1-ethynyl-4-(methylsulfonyl)benzene	139-174	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-53
31341381-10	2019	NaCl-induced expression of COX2 was mediated by various intracellular signal transduction molecules (p38 mitogen-activated protein kinase [p38 MAPK], extracellular signal-regulated kinases 1 and 2 [ERK1/2], and phosphatidylinositol-3 kinase [PI3K]), intracellular calcium signaling involving activation of phospholipase Cgamma (PLCgamma) and protein kinase Calpha/beta (PKCalpha/beta), and the activity of nuclear factor of activated T cell 5 (NFAT5).	Sodium Chloride	0-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-31
31341381-10	2019	NaCl-induced expression of COX2 was mediated by various intracellular signal transduction molecules (p38 mitogen-activated protein kinase [p38 MAPK], extracellular signal-regulated kinases 1 and 2 [ERK1/2], and phosphatidylinositol-3 kinase [PI3K]), intracellular calcium signaling involving activation of phospholipase Cgamma (PLCgamma) and protein kinase Calpha/beta (PKCalpha/beta), and the activity of nuclear factor of activated T cell 5 (NFAT5).	Calcium	264-271	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-31
31341381-11	2019	Inhibition of fibroblast growth factor (FGF), transforming growth factor-beta (TGF-beta), and interleukin-1 (IL-1) receptor activities decreased NaCl-induced COX2 gene expression.	Sodium Chloride	145-149	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	158-162
31341381-12	2019	Selective inhibition of COX2 activity decreased osmotic expression of the VEGFA, IL1B, and NLRP3 genes, and blocked the NaCl-induced increase in the cytosolic IL-1beta level.	Sodium Chloride	120-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-28
31140528-1	2019	We are reporting Co(ii) and Ni(ii) complexes of a pyridine containing aromatic macrocyclic triamide ligand, 3,6,9,15-tetraazabicyclo(9.3.1)pentadeca-1(15),11,13-triene-3,6,9-triacetamide (TPTA), as paramagnetic chemical exchange saturation transfer (paraCEST) MRI contrast agents.	pyridine	50-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-23
31140528-1	2019	We are reporting Co(ii) and Ni(ii) complexes of a pyridine containing aromatic macrocyclic triamide ligand, 3,6,9,15-tetraazabicyclo(9.3.1)pentadeca-1(15),11,13-triene-3,6,9-triacetamide (TPTA), as paramagnetic chemical exchange saturation transfer (paraCEST) MRI contrast agents.	pyridine	50-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-22
31140528-1	2019	We are reporting Co(ii) and Ni(ii) complexes of a pyridine containing aromatic macrocyclic triamide ligand, 3,6,9,15-tetraazabicyclo(9.3.1)pentadeca-1(15),11,13-triene-3,6,9-triacetamide (TPTA), as paramagnetic chemical exchange saturation transfer (paraCEST) MRI contrast agents.	Hempa	91-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-23
31140528-1	2019	We are reporting Co(ii) and Ni(ii) complexes of a pyridine containing aromatic macrocyclic triamide ligand, 3,6,9,15-tetraazabicyclo(9.3.1)pentadeca-1(15),11,13-triene-3,6,9-triacetamide (TPTA), as paramagnetic chemical exchange saturation transfer (paraCEST) MRI contrast agents.	Hempa	91-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-22
31140528-1	2019	We are reporting Co(ii) and Ni(ii) complexes of a pyridine containing aromatic macrocyclic triamide ligand, 3,6,9,15-tetraazabicyclo(9.3.1)pentadeca-1(15),11,13-triene-3,6,9-triacetamide (TPTA), as paramagnetic chemical exchange saturation transfer (paraCEST) MRI contrast agents.	3,6,9,15-tetraazabicyclo	108-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-23
31140528-1	2019	We are reporting Co(ii) and Ni(ii) complexes of a pyridine containing aromatic macrocyclic triamide ligand, 3,6,9,15-tetraazabicyclo(9.3.1)pentadeca-1(15),11,13-triene-3,6,9-triacetamide (TPTA), as paramagnetic chemical exchange saturation transfer (paraCEST) MRI contrast agents.	3,6,9,15-tetraazabicyclo	108-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-22
31140528-1	2019	We are reporting Co(ii) and Ni(ii) complexes of a pyridine containing aromatic macrocyclic triamide ligand, 3,6,9,15-tetraazabicyclo(9.3.1)pentadeca-1(15),11,13-triene-3,6,9-triacetamide (TPTA), as paramagnetic chemical exchange saturation transfer (paraCEST) MRI contrast agents.	pentadeca-1	139-150	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-23
31140528-1	2019	We are reporting Co(ii) and Ni(ii) complexes of a pyridine containing aromatic macrocyclic triamide ligand, 3,6,9,15-tetraazabicyclo(9.3.1)pentadeca-1(15),11,13-triene-3,6,9-triacetamide (TPTA), as paramagnetic chemical exchange saturation transfer (paraCEST) MRI contrast agents.	pentadeca-1	139-150	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-22
31140528-1	2019	We are reporting Co(ii) and Ni(ii) complexes of a pyridine containing aromatic macrocyclic triamide ligand, 3,6,9,15-tetraazabicyclo(9.3.1)pentadeca-1(15),11,13-triene-3,6,9-triacetamide (TPTA), as paramagnetic chemical exchange saturation transfer (paraCEST) MRI contrast agents.	11,13-triene-3,6,9-triacetamide	155-186	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-23
31140528-1	2019	We are reporting Co(ii) and Ni(ii) complexes of a pyridine containing aromatic macrocyclic triamide ligand, 3,6,9,15-tetraazabicyclo(9.3.1)pentadeca-1(15),11,13-triene-3,6,9-triacetamide (TPTA), as paramagnetic chemical exchange saturation transfer (paraCEST) MRI contrast agents.	11,13-triene-3,6,9-triacetamide	155-186	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-22
31140528-1	2019	We are reporting Co(ii) and Ni(ii) complexes of a pyridine containing aromatic macrocyclic triamide ligand, 3,6,9,15-tetraazabicyclo(9.3.1)pentadeca-1(15),11,13-triene-3,6,9-triacetamide (TPTA), as paramagnetic chemical exchange saturation transfer (paraCEST) MRI contrast agents.	phentin acetate	188-192	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-23
31140528-1	2019	We are reporting Co(ii) and Ni(ii) complexes of a pyridine containing aromatic macrocyclic triamide ligand, 3,6,9,15-tetraazabicyclo(9.3.1)pentadeca-1(15),11,13-triene-3,6,9-triacetamide (TPTA), as paramagnetic chemical exchange saturation transfer (paraCEST) MRI contrast agents.	phentin acetate	188-192	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-22
30780143-6	2019	The life-prolonged electrons, together with Co (II) in CoMoO4, effectively activated the persulfate, and a concentration of steady-state [Formula: see text] as high as 1.8 x 10-14 mol   l-1 was obtained.	comoo4	55-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-51
31250221-7	2019	Further, Qu (0.12%) + TiO2 (15%) nanogel significantly (p &lt; 0.001) downregulated COX-2, EP3, EP4, PCNA, and cyclin D1 expressions in contrast to Qu and TiO2 only pretreated groups.	titanium dioxide	22-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-89
30780143-6	2019	The life-prolonged electrons, together with Co (II) in CoMoO4, effectively activated the persulfate, and a concentration of steady-state [Formula: see text] as high as 1.8 x 10-14 mol   l-1 was obtained.	Peroxydisulfate	89-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-51
31489168-5	2019	These show the peptide is trimeric and binds to both Cu(ii) and Ni(ii) in a 1 : 1 ratio with the histidine residues involved in the metal coordination, as designed.	Histidine	97-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-58
31064184-2	2019	This approach was utilized for developing a Co(II)[salen]-catalyzed aerobic oxidative cross-coupling of phenols in a recyclable 1,1,1,3,3,3-hexafluoropropan-2-ol (HFIP) solvent.	disalicylaldehyde ethylenediamine	51-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-50
31064184-2	2019	This approach was utilized for developing a Co(II)[salen]-catalyzed aerobic oxidative cross-coupling of phenols in a recyclable 1,1,1,3,3,3-hexafluoropropan-2-ol (HFIP) solvent.	Phenols	104-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-50
31064184-2	2019	This approach was utilized for developing a Co(II)[salen]-catalyzed aerobic oxidative cross-coupling of phenols in a recyclable 1,1,1,3,3,3-hexafluoropropan-2-ol (HFIP) solvent.	hexafluoroisopropanol	128-161	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-50
31064184-2	2019	This approach was utilized for developing a Co(II)[salen]-catalyzed aerobic oxidative cross-coupling of phenols in a recyclable 1,1,1,3,3,3-hexafluoropropan-2-ol (HFIP) solvent.	hexafluoroisopropanol	163-167	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-50
31489168-5	2019	These show the peptide is trimeric and binds to both Cu(ii) and Ni(ii) in a 1 : 1 ratio with the histidine residues involved in the metal coordination, as designed.	Histidine	97-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-69
31489168-5	2019	These show the peptide is trimeric and binds to both Cu(ii) and Ni(ii) in a 1 : 1 ratio with the histidine residues involved in the metal coordination, as designed.	Metals	132-137	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-69
30941384-1	2019	A novel one-dimensional CoII coordination polymer (OPD)2CoIISO4 was formed from alternating tetrahedral sulphate anions, Co centers and molecules of 1,2-phenylenediamine (OPD).	tetrahedral sulphate	92-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-28
30941384-1	2019	A novel one-dimensional CoII coordination polymer (OPD)2CoIISO4 was formed from alternating tetrahedral sulphate anions, Co centers and molecules of 1,2-phenylenediamine (OPD).	1,2-diaminobenzene	149-169	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-28
31066416-3	2019	The ligand (H2L) comprises two different asymmetric binding pockets; however, when reacted with Mn(ii), Co(ii), Cu(ii) and Zn(ii) salts, very stable self-assembled [2 x 2] grid complexes form regardless of the employed metal-to-ligand ratio.	h2l	12-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-101
30971474-6	2019	Furthermore, we could demonstrate that MDV infection activates the COX-2/prostaglandin E2 (PGE2) pathway, as evident by increased levels of arachidonic acid, COX-2 expression, and PGE2 synthesis.	Dinoprostone	91-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-89
30971474-6	2019	Furthermore, we could demonstrate that MDV infection activates the COX-2/prostaglandin E2 (PGE2) pathway, as evident by increased levels of arachidonic acid, COX-2 expression, and PGE2 synthesis.	Dinoprostone	91-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-72
30971474-6	2019	Furthermore, we could demonstrate that MDV infection activates the COX-2/prostaglandin E2 (PGE2) pathway, as evident by increased levels of arachidonic acid, COX-2 expression, and PGE2 synthesis.	Arachidonic Acid	140-156	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-89
30971474-6	2019	Furthermore, we could demonstrate that MDV infection activates the COX-2/prostaglandin E2 (PGE2) pathway, as evident by increased levels of arachidonic acid, COX-2 expression, and PGE2 synthesis.	Arachidonic Acid	140-156	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-72
30971474-6	2019	Furthermore, we could demonstrate that MDV infection activates the COX-2/prostaglandin E2 (PGE2) pathway, as evident by increased levels of arachidonic acid, COX-2 expression, and PGE2 synthesis.	Dinoprostone	180-184	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-89
30971474-6	2019	Furthermore, we could demonstrate that MDV infection activates the COX-2/prostaglandin E2 (PGE2) pathway, as evident by increased levels of arachidonic acid, COX-2 expression, and PGE2 synthesis.	Dinoprostone	180-184	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-72
30971474-7	2019	Inhibition of the COX-2/PGE2 pathway by chemical inhibitors or knockdown of COX2 using short hairpin RNA reduced MDV titers, suggesting that COX-2 promotes virus replication.	Dinoprostone	24-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	141-146
30971474-8	2019	Exogenous PGE2 completely restored the inhibition of the COX-2/PGE2 pathway in MDV replication.	Dinoprostone	10-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-62
30971474-8	2019	Exogenous PGE2 completely restored the inhibition of the COX-2/PGE2 pathway in MDV replication.	Dinoprostone	63-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-62
30971474-14	2019	Finally, our results reveal that MDV also activates the COX-2/PGE2 pathway, which supports MDV replication by activating PGE2/EP2 and PGE2/EP4 signaling pathways.	Dinoprostone	62-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-61
30971474-14	2019	Finally, our results reveal that MDV also activates the COX-2/PGE2 pathway, which supports MDV replication by activating PGE2/EP2 and PGE2/EP4 signaling pathways.	Dinoprostone	121-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-61
30971474-14	2019	Finally, our results reveal that MDV also activates the COX-2/PGE2 pathway, which supports MDV replication by activating PGE2/EP2 and PGE2/EP4 signaling pathways.	Dinoprostone	121-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-61
31197585-3	2019	ALP specifically catalyzes the hydrolysis of ascorbic acid-2-phosphate to produce ascorbic acid which reduces CoOOH nanoflakes to Co(II) ion.	ascorbate-2-phosphate	45-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	130-136
31197585-3	2019	ALP specifically catalyzes the hydrolysis of ascorbic acid-2-phosphate to produce ascorbic acid which reduces CoOOH nanoflakes to Co(II) ion.	Ascorbic Acid	45-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	130-136
31197585-3	2019	ALP specifically catalyzes the hydrolysis of ascorbic acid-2-phosphate to produce ascorbic acid which reduces CoOOH nanoflakes to Co(II) ion.	coooh	110-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	130-136
31083943-0	2019	Biomimetic Self-Assembly of CoII-Seamed Hexameric Metal-Organic Nanocapsules.	Metals	50-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-32
31231223-4	2019	Inhibition of mPGES-1 decreased PGE2 production and increased PGF2alpha and thromboxane B2 (TXB2) formation, while inhibition of COX-2 decreased the production of all three prostanoids.	Prostaglandins	173-184	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-134
31231223-8	2019	Inhibition of mPGES-1 increased the concentration of sphinganine and dihydroceramide (C16:0DhCer), while inhibition of COX-2 caused a general decrease in most ceramides, again suggesting different effects on cell death between the two inhibitors.	Ceramides	159-168	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-124
31117505-3	2019	Z-Astaxanthins, especially 9 Z-astaxanthin exhibited greater anti-inflammatory effect than all- E-astaxanthin by down-regulating pro-inflammatory cytokines COX-2 and TNF-alpha gene expression to 0.88 +- 0.01-fold and 0.83 +- 0.17-fold that of the negative control (NC), respectively.	z-astaxanthins	0-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	156-161
31117505-3	2019	Z-Astaxanthins, especially 9 Z-astaxanthin exhibited greater anti-inflammatory effect than all- E-astaxanthin by down-regulating pro-inflammatory cytokines COX-2 and TNF-alpha gene expression to 0.88 +- 0.01-fold and 0.83 +- 0.17-fold that of the negative control (NC), respectively.	z-astaxanthin	29-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	156-161
31117505-3	2019	Z-Astaxanthins, especially 9 Z-astaxanthin exhibited greater anti-inflammatory effect than all- E-astaxanthin by down-regulating pro-inflammatory cytokines COX-2 and TNF-alpha gene expression to 0.88 +- 0.01-fold and 0.83 +- 0.17-fold that of the negative control (NC), respectively.	all- e-astaxanthin	91-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	156-161
31083917-3	2019	While many divalent metals bind to poly histidine sequences reversibly, oxidation of imidazole-bound CoII or RuII is known to result in a dramatic increase of the binding strength.	polyhistidine	35-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-105
31083917-3	2019	While many divalent metals bind to poly histidine sequences reversibly, oxidation of imidazole-bound CoII or RuII is known to result in a dramatic increase of the binding strength.	imidazole	85-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-105
31117627-1	2019	The behavior of single-ion magnets (SIMs) that reflects large distortions of their coordination environments caused by the packing of long alkyl chains for two Co(II) complexes of the type [Co(C n-terpy)2](BF4)2 (C n-terpy = 4"-alkoxy-2,2":6",2""-terpyridine; n = 10 (1), 16 (2)) is reported.	co(c n-terpy)2](bf4)2	190-211	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	160-166
31117627-1	2019	The behavior of single-ion magnets (SIMs) that reflects large distortions of their coordination environments caused by the packing of long alkyl chains for two Co(II) complexes of the type [Co(C n-terpy)2](BF4)2 (C n-terpy = 4"-alkoxy-2,2":6",2""-terpyridine; n = 10 (1), 16 (2)) is reported.	n-terpy	195-202	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	160-166
31117627-1	2019	The behavior of single-ion magnets (SIMs) that reflects large distortions of their coordination environments caused by the packing of long alkyl chains for two Co(II) complexes of the type [Co(C n-terpy)2](BF4)2 (C n-terpy = 4"-alkoxy-2,2":6",2""-terpyridine; n = 10 (1), 16 (2)) is reported.	4"-alkoxy-2,2":6",2""-terpyridine	225-258	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	160-166
31117627-4	2019	Surprisingly, 2 shows a reverse spin transition (rST) and also exhibits remarkable field-induced SIM behavior, revealing the presence of magnetic anisotropy for this high-spin Co(II) species that is triggered by a structural phase transition.	UNII-Y5T2AJP16N	49-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	176-182
30761522-1	2019	BACKGROUND AND PURPOSE: An up-regulation of COX-2 in malignant gliomas causes excessive synthesis of PGE2 , which is thought to facilitate brain tumour growth and invasion.	Dinoprostone	101-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-49
31066416-3	2019	The ligand (H2L) comprises two different asymmetric binding pockets; however, when reacted with Mn(ii), Co(ii), Cu(ii) and Zn(ii) salts, very stable self-assembled [2 x 2] grid complexes form regardless of the employed metal-to-ligand ratio.	h2l	12-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-110
31066416-3	2019	The ligand (H2L) comprises two different asymmetric binding pockets; however, when reacted with Mn(ii), Co(ii), Cu(ii) and Zn(ii) salts, very stable self-assembled [2 x 2] grid complexes form regardless of the employed metal-to-ligand ratio.	h2l	12-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-109
31066416-3	2019	The ligand (H2L) comprises two different asymmetric binding pockets; however, when reacted with Mn(ii), Co(ii), Cu(ii) and Zn(ii) salts, very stable self-assembled [2 x 2] grid complexes form regardless of the employed metal-to-ligand ratio.	h2l	12-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-109
31066416-3	2019	The ligand (H2L) comprises two different asymmetric binding pockets; however, when reacted with Mn(ii), Co(ii), Cu(ii) and Zn(ii) salts, very stable self-assembled [2 x 2] grid complexes form regardless of the employed metal-to-ligand ratio.	Metals	219-224	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-101
31066416-3	2019	The ligand (H2L) comprises two different asymmetric binding pockets; however, when reacted with Mn(ii), Co(ii), Cu(ii) and Zn(ii) salts, very stable self-assembled [2 x 2] grid complexes form regardless of the employed metal-to-ligand ratio.	Metals	219-224	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-110
31066416-3	2019	The ligand (H2L) comprises two different asymmetric binding pockets; however, when reacted with Mn(ii), Co(ii), Cu(ii) and Zn(ii) salts, very stable self-assembled [2 x 2] grid complexes form regardless of the employed metal-to-ligand ratio.	Metals	219-224	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-109
31066416-3	2019	The ligand (H2L) comprises two different asymmetric binding pockets; however, when reacted with Mn(ii), Co(ii), Cu(ii) and Zn(ii) salts, very stable self-assembled [2 x 2] grid complexes form regardless of the employed metal-to-ligand ratio.	Metals	219-224	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-109
30761522-5	2019	A time-resolved FRET method was used to identify the EP subtype that mediates COX-2/PGE2 -initiated cAMP signalling in human GBM cells.	Dinoprostone	84-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-83
30761522-5	2019	A time-resolved FRET method was used to identify the EP subtype that mediates COX-2/PGE2 -initiated cAMP signalling in human GBM cells.	Cyclic AMP	100-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-83
30761522-7	2019	KEY RESULTS: The EP2 receptor is a key Galphas -coupled receptor that mediates COX-2/PGE2 -initiated cAMP signalling pathways in human malignant glioma cells.	Dinoprostone	85-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-84
30761522-7	2019	KEY RESULTS: The EP2 receptor is a key Galphas -coupled receptor that mediates COX-2/PGE2 -initiated cAMP signalling pathways in human malignant glioma cells.	Cyclic AMP	101-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-84
31063976-7	2019	In the present study, we reported the first case of HPGD mutated PHO patient with soft tissue giant tumors at lower legs and evaluated the efficacy of selective COX-2 inhibitor (Etorcoxib) treatment in the patient.	etorcoxib	178-187	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	161-166
31132889-1	2019	INTRODUCTION: COX-2 is a key enzyme in the process of prostaglandins (PGs) synthesis.	Prostaglandins	54-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
30928706-8	2019	Analysis of the docked poses of the compounds showed that they adopt similar conformations to the highly selective COX-2 inhibitor, SC-558.	SC 558	132-138	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-120
30928706-10	2019	All the tested compounds exhibited potent inhibitory effect on the production of PGE2, in addition to their inhibition of COX-2 enzyme.	Dinoprostone	81-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-127
30928709-0	2019	Novel benzenesulfonamide and 1,2-benzisothiazol-3(2H)-one-1,1-dioxide derivatives as potential selective COX-2 inhibitors.	benzenesulfonamide	6-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-110
30928709-0	2019	Novel benzenesulfonamide and 1,2-benzisothiazol-3(2H)-one-1,1-dioxide derivatives as potential selective COX-2 inhibitors.	Saccharin	29-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-110
30928709-1	2019	Two new series of 1,2-benzisothiazol-3(2H)-one-1,1-dioxide derivatives containing either five membered heterocyclic rings or aryl hydrazones were synthesized and evaluated for their in vitro COX-1/COX-2 inhibitory activity.	Saccharin	18-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	197-202
30928709-5	2019	Benzenesulfonamide derivatives 19 and 20 displayed higher predicted binding affinities inside the COX-2 active site.	benzenesulfonamide	0-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-103
31132889-1	2019	INTRODUCTION: COX-2 is a key enzyme in the process of prostaglandins (PGs) synthesis.	Prostaglandins	70-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
30466341-4	2019	Results: LPS-induced expressions of pro-inflammatory genes IL-6, IL-8, TNF-alpha, IL-1beta, MCP-1, MMP-9, iNOS and COX-2 were significantly and dose-dependently suppressed by XAV939.	XAV939	175-181	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-120
30659877-5	2019	In addition, LRWXG can significantly reduce the levels of inflammatory-related factors such as COX2, PEG2, TNFalpha and IL1beta, and inhibits the expression of MMPs, increasing the content of type II collagen.	lrwxg	13-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-99
31147783-5	2019	Rather, a CoIII-H species needs to be reduced to CoII-H before H2 can be produced.	Deuterium	63-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-14
31281501-8	2019	Histamine-mediated upregulation of the COX-2 signaling pathway was shown to play a crucial role in suppression of the allergic immune response by MC-pretreated hUCB-MSCs.	Histamine	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-44
30712126-0	2019	Correction to: Identification of beta-carboline and canthinone alkaloids as anti-inflammatory agents but with different inhibitory profile on the expression of iNOS and COX-2 in lipopolysaccharide-activated RAW 264.7 macrophages.	norharman	33-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	169-174
30712126-0	2019	Correction to: Identification of beta-carboline and canthinone alkaloids as anti-inflammatory agents but with different inhibitory profile on the expression of iNOS and COX-2 in lipopolysaccharide-activated RAW 264.7 macrophages.	canthinone alkaloids	52-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	169-174
31214060-5	2019	The COX-2 inhibitor celecoxib was found to have a significant positive effect on major depression, not only in single studies but also in meta-analyses.	Celecoxib	20-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
31191326-0	2019	Saikosaponin-d Suppresses COX2 Through p-STAT3/C/EBPbeta Signaling Pathway in Liver Cancer: A Novel Mechanism of Action.	saikosaponin D	0-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-30
31191326-8	2019	AG490 produced similar inhibitory effects on STAT3, p-STAT3, C/EBPbeta, and COX-2.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	0-5	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-81
30848866-1	2019	Strontium-substituted lanthanum cobaltite (La0.8 Sr0.2 CoO3 ) matrix-stabilized Co0 /CoII catalytic sites were prepared, which present tunable C-O and C-C hydrogenolysis activity for the vapor-phase upgrading of oxygenated arenes.	Strontium	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-89
30848866-1	2019	Strontium-substituted lanthanum cobaltite (La0.8 Sr0.2 CoO3 ) matrix-stabilized Co0 /CoII catalytic sites were prepared, which present tunable C-O and C-C hydrogenolysis activity for the vapor-phase upgrading of oxygenated arenes.	Lanthanum	22-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-89
30740917-0	2019	Anchoring CoII Ions into a Thiol-Laced Metal-Organic Framework for Efficient Visible-Light-Driven Conversion of CO2 into CO.	Sulfhydryl Compounds	27-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-14
30848866-1	2019	Strontium-substituted lanthanum cobaltite (La0.8 Sr0.2 CoO3 ) matrix-stabilized Co0 /CoII catalytic sites were prepared, which present tunable C-O and C-C hydrogenolysis activity for the vapor-phase upgrading of oxygenated arenes.	cobaltite	32-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-89
30740917-0	2019	Anchoring CoII Ions into a Thiol-Laced Metal-Organic Framework for Efficient Visible-Light-Driven Conversion of CO2 into CO.	Metals	39-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-14
30848866-1	2019	Strontium-substituted lanthanum cobaltite (La0.8 Sr0.2 CoO3 ) matrix-stabilized Co0 /CoII catalytic sites were prepared, which present tunable C-O and C-C hydrogenolysis activity for the vapor-phase upgrading of oxygenated arenes.	coo3	55-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-89
30740917-0	2019	Anchoring CoII Ions into a Thiol-Laced Metal-Organic Framework for Efficient Visible-Light-Driven Conversion of CO2 into CO.	N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)-4-((4-fluorobenzyl)oxy)pyridine-2,6-dicarboxamide	112-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-14
30740917-0	2019	Anchoring CoII Ions into a Thiol-Laced Metal-Organic Framework for Efficient Visible-Light-Driven Conversion of CO2 into CO.	Carbon Monoxide	112-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-14
30740917-3	2019	To address this, catalytically active CoII centers can be anchored into the porous matrix of metal-organic frameworks (MOFs) by utilizing a robust Zr-based MOF (Zr-DMBD) functionalized with freestanding thiol groups to enable efficient post-synthetic metal insertion.	Metals	93-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-42
30848866-1	2019	Strontium-substituted lanthanum cobaltite (La0.8 Sr0.2 CoO3 ) matrix-stabilized Co0 /CoII catalytic sites were prepared, which present tunable C-O and C-C hydrogenolysis activity for the vapor-phase upgrading of oxygenated arenes.	CO0	80-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-89
30848866-1	2019	Strontium-substituted lanthanum cobaltite (La0.8 Sr0.2 CoO3 ) matrix-stabilized Co0 /CoII catalytic sites were prepared, which present tunable C-O and C-C hydrogenolysis activity for the vapor-phase upgrading of oxygenated arenes.	arenes	223-229	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-89
30848866-2	2019	CoII sites associated with oxygen vacancies were favored at low temperatures and performed selective C-O hydrogenolysis, in which Sr-substitution facilitated oxygen vacancy formation, leading to approximately 10 times higher reactivity compared to undoped LaCoO3 .	Oxygen	27-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-4
30848866-2	2019	CoII sites associated with oxygen vacancies were favored at low temperatures and performed selective C-O hydrogenolysis, in which Sr-substitution facilitated oxygen vacancy formation, leading to approximately 10 times higher reactivity compared to undoped LaCoO3 .	Oxygen	158-164	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-4
30848866-2	2019	CoII sites associated with oxygen vacancies were favored at low temperatures and performed selective C-O hydrogenolysis, in which Sr-substitution facilitated oxygen vacancy formation, leading to approximately 10 times higher reactivity compared to undoped LaCoO3 .	lacoo3	256-262	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-4
30848866-5	2019	The Co3 O4 surfaces featured a narrower temperature window for obtaining the respective optimal CoII and Co0 pairs compared to analogous perovskite surfaces; whereas, the perovskite matrix stabilizes these pairs for selective C-O and C-C hydrogenolysis.	co3 o4	4-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-100
31041973-1	2019	A coordination compound with the composition [CoLCl2] H2O (L = bis-condensation product of diacetyl and 2-hydrazinyl-4,6-dimethylpyrimidine) was synthesized, in which the Co(ii) ion was hexacoordinated.	colcl2	46-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	171-177
31041973-1	2019	A coordination compound with the composition [CoLCl2] H2O (L = bis-condensation product of diacetyl and 2-hydrazinyl-4,6-dimethylpyrimidine) was synthesized, in which the Co(ii) ion was hexacoordinated.	Water	54-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	171-177
31041973-1	2019	A coordination compound with the composition [CoLCl2] H2O (L = bis-condensation product of diacetyl and 2-hydrazinyl-4,6-dimethylpyrimidine) was synthesized, in which the Co(ii) ion was hexacoordinated.	2-hydrazinyl-4,6-dimethylpyrimidine	104-139	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	171-177
31113934-4	2019	Bioinformatics suggested that transcription factor AP-2 beta (TFAP2B) might specifically bind to the COX-2 promoter, which was confirmed by biotin-labeled COX-2 promoter pulldown and luciferase reporter assays.	Biotin	140-146	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-106
31113934-4	2019	Bioinformatics suggested that transcription factor AP-2 beta (TFAP2B) might specifically bind to the COX-2 promoter, which was confirmed by biotin-labeled COX-2 promoter pulldown and luciferase reporter assays.	Biotin	140-146	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	155-160
30884075-4	2019	When the resulting CoII -H species was exposed to N2 , H2 evolution readily occurs at ambient conditions.	Nitrogen	50-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-23
30884075-4	2019	When the resulting CoII -H species was exposed to N2 , H2 evolution readily occurs at ambient conditions.	Hydrogen	55-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-23
31113465-13	2019	Among genes overexpressed in polarizing cells, we identified the prostaglandin-endoperoxide synthase enzyme (PTGS2/COX-2), which is involved in the production of prostaglandin E2 (PGE2).	Prostaglandins	65-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-120
31113465-13	2019	Among genes overexpressed in polarizing cells, we identified the prostaglandin-endoperoxide synthase enzyme (PTGS2/COX-2), which is involved in the production of prostaglandin E2 (PGE2).	Dinoprostone	162-178	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-120
31113465-13	2019	Among genes overexpressed in polarizing cells, we identified the prostaglandin-endoperoxide synthase enzyme (PTGS2/COX-2), which is involved in the production of prostaglandin E2 (PGE2).	Dinoprostone	180-184	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-120
31113465-14	2019	By using COX-2 inhibitors we demonstrated that the M2-like polarization ability of thyroid cells is related to the production of PGE2.	Dinoprostone	129-133	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	9-14
31341591-3	2019	In [CoCl3(DABCO)(HDABCO)] (1), the trigonal bipyramidal Co(ii) centre has two bulky axial ligands and three equatorial chloride ligands.	cocl3	4-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-62
31341591-3	2019	In [CoCl3(DABCO)(HDABCO)] (1), the trigonal bipyramidal Co(ii) centre has two bulky axial ligands and three equatorial chloride ligands.	triethylenediamine	10-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-62
31341591-3	2019	In [CoCl3(DABCO)(HDABCO)] (1), the trigonal bipyramidal Co(ii) centre has two bulky axial ligands and three equatorial chloride ligands.	hdabco)	17-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-62
31341591-3	2019	In [CoCl3(DABCO)(HDABCO)] (1), the trigonal bipyramidal Co(ii) centre has two bulky axial ligands and three equatorial chloride ligands.	Chlorides	119-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-62
30928409-11	2019	Moreover, 8-Br-cAMP and CAPE could inhibit AGE-induced secretion of interleukin(IL)-1beta, prostaglandin E2(PEG2) and cyclooxygenase 2(COX2).	8-Bromo Cyclic Adenosine Monophosphate	10-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-139
30740917-3	2019	To address this, catalytically active CoII centers can be anchored into the porous matrix of metal-organic frameworks (MOFs) by utilizing a robust Zr-based MOF (Zr-DMBD) functionalized with freestanding thiol groups to enable efficient post-synthetic metal insertion.	Zirconium	147-149	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-42
30740917-3	2019	To address this, catalytically active CoII centers can be anchored into the porous matrix of metal-organic frameworks (MOFs) by utilizing a robust Zr-based MOF (Zr-DMBD) functionalized with freestanding thiol groups to enable efficient post-synthetic metal insertion.	dmbd	164-168	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-42
30740917-3	2019	To address this, catalytically active CoII centers can be anchored into the porous matrix of metal-organic frameworks (MOFs) by utilizing a robust Zr-based MOF (Zr-DMBD) functionalized with freestanding thiol groups to enable efficient post-synthetic metal insertion.	Sulfhydryl Compounds	203-208	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-42
30740917-3	2019	To address this, catalytically active CoII centers can be anchored into the porous matrix of metal-organic frameworks (MOFs) by utilizing a robust Zr-based MOF (Zr-DMBD) functionalized with freestanding thiol groups to enable efficient post-synthetic metal insertion.	Metals	251-256	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-42
30848866-0	2019	Cooperative Co0 /CoII Sites Stabilized by a Perovskite Matrix Enable Selective C-O and C-C bond Hydrogenolysis of Oxygenated Arenes.	perovskite	44-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-21
30848866-0	2019	Cooperative Co0 /CoII Sites Stabilized by a Perovskite Matrix Enable Selective C-O and C-C bond Hydrogenolysis of Oxygenated Arenes.	arenes	125-131	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-21
31109093-4	2019	Moreover, AE-COS treatment caused suppression on COX-2 expression in a dose-dependent manner.	carbonyl sulfide	13-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-54
31100089-9	2019	catechin inhibited the gene expression of pro-inflammatory cytokines including IL-1alpha, IL-1beta, IL-6, IL-12p35, and inflammatory enzymes including iNOS and COX-2, but enhanced the gene expression of anti-inflammatory cytokines including IL-4 and IL-10.	Catechin	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	160-165
31205453-1	2019	This paper includes synthesis and characterization of mixed ligand complexes derived from mefenamic acid and metformin using transition metal ions such as Co(II) and Cu(II).	Mefenamic Acid	90-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	155-161
30865746-0	2019	A visible chemosensor based on carbohydrazide for Fe(ii), Co(ii) and Cu(ii) in aqueous solution.	carbohydrazide	31-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-55
30865746-0	2019	A visible chemosensor based on carbohydrazide for Fe(ii), Co(ii) and Cu(ii) in aqueous solution.	carbohydrazide	31-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-64
30865746-0	2019	A visible chemosensor based on carbohydrazide for Fe(ii), Co(ii) and Cu(ii) in aqueous solution.	carbohydrazide	31-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-63
30865746-1	2019	A colorimetric sensor with pyridyl and carbohydrazide components has been synthesized and visibly turns blue in the presence of Fe(ii).	phenyl-(2-pyridyl)-(3-pyridyl)-(4-pyridyl)-methane	27-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-133
30865746-1	2019	A colorimetric sensor with pyridyl and carbohydrazide components has been synthesized and visibly turns blue in the presence of Fe(ii).	carbohydrazide	39-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-133
30865746-4	2019	The binding ratio of the sensor to Fe(ii), Co(ii), and Cu(ii) is 2 sensors to 1 metal ion.	Metals	80-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-40
30865746-4	2019	The binding ratio of the sensor to Fe(ii), Co(ii), and Cu(ii) is 2 sensors to 1 metal ion.	Metals	80-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
30865746-4	2019	The binding ratio of the sensor to Fe(ii), Co(ii), and Cu(ii) is 2 sensors to 1 metal ion.	Metals	80-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-48
30865746-7	2019	The sensor"s color response to Cu(ii) is uniquely attenuated by glutathione.	Glutathione	64-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-36
31193104-0	2019	Distinctive coordination behavior of a pyrazole imine-oxime compound towards Co(II) and Ni(II).	pyrazole imine-oxime	39-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-83
31020835-6	2019	The [(PHOX)CoX2] (X = Cl, Br) complexes give mostly 1,4-addition with linear unsubstituted 1,3-dienes, but, surprisingly, selective 1,2-additions with 2-substituted or 2,3-disubstituted 1,3-dienes.	Bromine	26-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-15
31020835-6	2019	The [(PHOX)CoX2] (X = Cl, Br) complexes give mostly 1,4-addition with linear unsubstituted 1,3-dienes, but, surprisingly, selective 1,2-additions with 2-substituted or 2,3-disubstituted 1,3-dienes.	1,3-dienes	91-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-15
31020835-6	2019	The [(PHOX)CoX2] (X = Cl, Br) complexes give mostly 1,4-addition with linear unsubstituted 1,3-dienes, but, surprisingly, selective 1,2-additions with 2-substituted or 2,3-disubstituted 1,3-dienes.	2,3-disubstituted 1,3-dienes	168-196	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-15
31205453-1	2019	This paper includes synthesis and characterization of mixed ligand complexes derived from mefenamic acid and metformin using transition metal ions such as Co(II) and Cu(II).	Metformin	109-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	155-161
31205453-1	2019	This paper includes synthesis and characterization of mixed ligand complexes derived from mefenamic acid and metformin using transition metal ions such as Co(II) and Cu(II).	Metals	136-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	155-161
30997801-0	2019	Three Co(II) Metal-Organic Frameworks with Diverse Architectures for Selective Gas Sorption and Magnetic Studies.	Metals	13-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	6-12
30951298-5	2019	The central transition-metal ion M n+ (MnII, FeIII, CoII, NiII, CuII, ZnII, PdII) in the POP structure and also the nature of the capping group (AsO43-, SeO32-, PO43-, phenyl-AsO32-) influence the resulting catalytic performance.	Metals	23-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-56
30951298-5	2019	The central transition-metal ion M n+ (MnII, FeIII, CoII, NiII, CuII, ZnII, PdII) in the POP structure and also the nature of the capping group (AsO43-, SeO32-, PO43-, phenyl-AsO32-) influence the resulting catalytic performance.	Nitrogen	35-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-56
31007025-2	2019	These Co(II) coordination polymers (CPs) have been obtained as stable crystalline materials and characterized by conventional solid-state techniques, including X-ray crystallography.	cps	36-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	6-12
31016970-0	2019	Inclusion of Ln(III) in the Complexes of Co(II) with a Mannich Base Ligand: Development of Atmospheric CO2 Fixation and Enhancement of Catalytic Oxidase Activities.	Mannich Bases	55-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-47
31007025-7	2019	In fact, the Co(II) compounds act as heterogeneous catalysts for the oxidation of alcohols with tBuOOH ( tert-butylhydroperoxide) under mild conditions.	Alcohols	82-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-19
31007025-7	2019	In fact, the Co(II) compounds act as heterogeneous catalysts for the oxidation of alcohols with tBuOOH ( tert-butylhydroperoxide) under mild conditions.	di-tert-butyl peroxide	96-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-19
31016970-0	2019	Inclusion of Ln(III) in the Complexes of Co(II) with a Mannich Base Ligand: Development of Atmospheric CO2 Fixation and Enhancement of Catalytic Oxidase Activities.	N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)-4-((4-fluorobenzyl)oxy)pyridine-2,6-dicarboxamide	103-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-47
31007025-7	2019	In fact, the Co(II) compounds act as heterogeneous catalysts for the oxidation of alcohols with tBuOOH ( tert-butylhydroperoxide) under mild conditions.	tert-Butylhydroperoxide	105-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-19
30776605-1	2019	In this study magnetic Prussian blue (MPB) was synthesized and applied as sorbent for the efficient removal of heavy metals (Cu (II), Co (II), Ni (II) and Pb (II)) from aqueous solution.	magnetic prussian blue	14-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-162
30776605-1	2019	In this study magnetic Prussian blue (MPB) was synthesized and applied as sorbent for the efficient removal of heavy metals (Cu (II), Co (II), Ni (II) and Pb (II)) from aqueous solution.	2-mercapto-1-(beta-4-pyridethyl)benzimidazole	38-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-162
30865374-0	2019	Phosphine Oxide Ligand Based Tetrahedral CoII Complexes with Field-induced Slow Magnetic Relaxation Behavior Modified by Terminal Ligands.	Phosphine oxide	0-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-45
30998018-0	2019	Co(II)-Catalyzed Regioselective Pyridine C-H Coupling with Diazoacetates.	pyridine c	32-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
30998018-0	2019	Co(II)-Catalyzed Regioselective Pyridine C-H Coupling with Diazoacetates.	diazoacetates	59-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
30998018-1	2019	A Co(II)-catalyzed pyridyl C-H bond carbenoid insertion with alpha-diazoacetates has been realized.	carbenoid	36-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	2-7
30998018-1	2019	A Co(II)-catalyzed pyridyl C-H bond carbenoid insertion with alpha-diazoacetates has been realized.	alpha-diazoacetates	61-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	2-7
30865374-1	2019	Two isostructural mononuclear CoII complexes, [Co(xantpo)(NCE)2 ] (E=S (1) and O (2); xantpo=9,9-dimethyl-4,5-bis(diphenylphosphoryl) xanthene), supported by a bidentate phosphine oxide ligand are reported.	co(xantpo)	47-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-34
30865374-1	2019	Two isostructural mononuclear CoII complexes, [Co(xantpo)(NCE)2 ] (E=S (1) and O (2); xantpo=9,9-dimethyl-4,5-bis(diphenylphosphoryl) xanthene), supported by a bidentate phosphine oxide ligand are reported.	xantpo	50-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-34
30865374-1	2019	Two isostructural mononuclear CoII complexes, [Co(xantpo)(NCE)2 ] (E=S (1) and O (2); xantpo=9,9-dimethyl-4,5-bis(diphenylphosphoryl) xanthene), supported by a bidentate phosphine oxide ligand are reported.	9,9-dimethyl-4,5-bis(diphenylphosphoryl) xanthene	93-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-34
31052601-0	2019	Temperature-Controlled Assembly/Reassembly of Two Dicarboxylate-Based Three-Dimensional Co(II) Coordination Polymers with an Antiferromagnetic Metallic Layer and a Ferromagnetic Metallic Chain.	malonic acid	50-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-94
31052601-0	2019	Temperature-Controlled Assembly/Reassembly of Two Dicarboxylate-Based Three-Dimensional Co(II) Coordination Polymers with an Antiferromagnetic Metallic Layer and a Ferromagnetic Metallic Chain.	coordination polymers	95-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-94
30763886-4	2019	Our best hit, 4d (COX-1 IC50 of 28 microM, COX-2 IC50 of 23 microM), appears to adopt similar binding modes to the standard COX-2 inhibitor, celecoxib, proposing room for possible selectivity.	Celecoxib	141-150	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	124-129
30794283-0	2019	Cooperative effects of sequential PGF2alpha and IL-1beta on IL-6 and COX-2 expression in human myometrial cells .	Dinoprost	34-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-74
30794283-5	2019	Sequential stimulation of HMSMC by PGF2alpha and IL-1beta in either order results in amplified upregulation of IL-6 and COX-2 mRNA and protein, compared to their effects individually.	Dinoprost	35-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-125
30794283-7	2019	These results suggest that PGF2alpha and IL-1beta act cooperatively upstream in the birth cascade to maximize amplification of IL-6 and COX-2, to build inflammatory load and thereby promote uterine transition.	Dinoprost	27-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	136-141
30763886-6	2019	Four compounds 3a (COX-2 IC50 of 42 microM), 3d, 4d and 4f were notable for their anti-inflammatory activity that was comparable to that of the clinically available COX-2 inhibitor celecoxib.	Celecoxib	181-190	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	165-170
30769266-9	2019	ADMET prediction results were also valuable to screen the most effective pyrazole derivatives to establish them as future COX-2 inhibitors or anti-inflammatory drugs.	pyrazole	73-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-127
30898436-0	2019	Structural modification of indomethacin toward selective inhibition of COX-2 with a significant increase in van der Waals contributions.	Indomethacin	27-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-76
30898436-1	2019	We have synthesized a fluorinated analogue of indomethacin bearing a 3,3,3-trifluoroprop-1-enyl group at its 2-position and evaluated its inhibitory activity towards the COX-1 and COX-2 enzymes in vitro.	Indomethacin	46-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	180-185
30776354-4	2019	In the present study, we used a gene microarray and western blotting analysis to show that the expression of mitochondrially encoded cytochrome c oxidase subunit 2 (MT-CO2, COXII) increased significantly in SH-SY5Y cells stimulated by alpha-Syn for 24 h. Furthermore, the decline in ATP levels, the decreased mitochondrial membrane potential, and the enhanced reactive oxygen species in cells treated by alpha-Syn was reversed by inhibiting MT-CO2 gene expression.	Adenosine Triphosphate	283-286	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	165-171
30898436-3	2019	The increased affinity between the fluorinated analogue and COX-2 was attributed to a significant increase in van der Waals contacts (i.e. van der Waals contributions in DeltaG were -13.80 kcal/mol for COX-1 and -18.46 kcal/mol for COX-2), explaining an effect of the fluorine substituent in enzyme selectivity.	Fluorine	268-276	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-65
30303592-9	2019	In vitro, 100 microM, but not 50 microM, of H2 O2 increased expression of TLR4, IL-1beta and COX-2.	Hydrogen Peroxide	44-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-98
30877972-0	2019	Design, synthesis and evaluation of novel diaryl-1,5-diazoles derivatives bearing morpholine as potent dual COX-2/5-LOX inhibitors and antitumor agents.	diaryl-1,5-diazoles	42-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-113
30877972-0	2019	Design, synthesis and evaluation of novel diaryl-1,5-diazoles derivatives bearing morpholine as potent dual COX-2/5-LOX inhibitors and antitumor agents.	morpholine	82-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-113
30776354-4	2019	In the present study, we used a gene microarray and western blotting analysis to show that the expression of mitochondrially encoded cytochrome c oxidase subunit 2 (MT-CO2, COXII) increased significantly in SH-SY5Y cells stimulated by alpha-Syn for 24 h. Furthermore, the decline in ATP levels, the decreased mitochondrial membrane potential, and the enhanced reactive oxygen species in cells treated by alpha-Syn was reversed by inhibiting MT-CO2 gene expression.	Oxygen	369-375	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	165-171
30877972-1	2019	In this paper, 41 hybrid compounds containing diaryl-1,5-diazole and morpholine structures acting as dual COX-2/5-LOX inhibitors have been designed, synthesized and biologically evaluated.	diaryl-1,5-diazole	46-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-111
31551208-6	2019	The expression levels of COX-2 and MMP-9 were both down-regulated by curcumin.	Curcumin	69-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-30
30877972-1	2019	In this paper, 41 hybrid compounds containing diaryl-1,5-diazole and morpholine structures acting as dual COX-2/5-LOX inhibitors have been designed, synthesized and biologically evaluated.	morpholine	69-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-111
30367494-4	2019	Here, we aimed to study the role of COX in PGE2 protumoral effects in PC3 cells and found that the effects were prevented by inhibition of COX-2, which highlights its crucial role amplifying the levels of iPGE2 .	Dinoprostone	43-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-144
30367494-4	2019	Here, we aimed to study the role of COX in PGE2 protumoral effects in PC3 cells and found that the effects were prevented by inhibition of COX-2, which highlights its crucial role amplifying the levels of iPGE2 .	ipge2	205-210	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-144
30367494-5	2019	Treatment with exogenous PGE2 determined a transcriptional increase in COX-2 expression, which was abolished by genetic or pharmacologic inhibition of PGT.	Dinoprostone	25-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-76
30367494-5	2019	Treatment with exogenous PGE2 determined a transcriptional increase in COX-2 expression, which was abolished by genetic or pharmacologic inhibition of PGT.	pgt	151-154	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-76
30367494-6	2019	PGE2 -induced increase in COX-2 expression and, thereby, in transcriptional increase in HIF-1alpha expression was due to EGFR activation, leading to the activation of Phosphoinositide 3-kinase/Akt, Extracellular signal -regulated kinases 1/2, p38 and Mitogen- and stress-activated protein kinase-1 (PI3K/Akt, Erk1/2, p38 and MSK-1).	Dinoprostone	0-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-31
30367494-7	2019	Collectively, the data suggest that EGFR-dependent COX-2 upregulation by a novel positive feedback loop triggered by iPGE2 underlies the intracrine pro-tumoral effects of PGE2 in PC3 cells.	ipge2	117-122	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-56
30367494-7	2019	Collectively, the data suggest that EGFR-dependent COX-2 upregulation by a novel positive feedback loop triggered by iPGE2 underlies the intracrine pro-tumoral effects of PGE2 in PC3 cells.	Dinoprostone	118-122	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-56
30367494-8	2019	Therefore, this feedback loop may be relevant in prostate cancer for the maintenance of PGE2 -dependent cancer cell growth through amplifying the activity of the COX-2 pathway.	Dinoprostone	88-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	162-167
30826638-8	2019	We estimated an annual 18,252.24 million tons of CO2 emissions (MtCO2) (95% CI = 9458.88-23,972.88) in China and 8281.76 MtCO2 (95% CI = 2765.68-14,959.12) in India in 2030.	N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)-4-((4-fluorobenzyl)oxy)pyridine-2,6-dicarboxamide	49-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-69
30673592-0	2019	Nanoliposomal formulation encapsulating celecoxib and genistein inhibiting COX-2 pathway and Glut-1 receptors to prevent prostate cancer cell proliferation.	Celecoxib	40-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
30968892-2	2019	The homovalent CoII and mixed-valence CoIII,II-imidazolate cages are assembled with control over the mixed solvent ratio of N,N-diethylformamide/ethanol, respectively.	N,N-diethylformamide	124-144	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-19
30968892-2	2019	The homovalent CoII and mixed-valence CoIII,II-imidazolate cages are assembled with control over the mixed solvent ratio of N,N-diethylformamide/ethanol, respectively.	Ethanol	145-152	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-19
30673592-0	2019	Nanoliposomal formulation encapsulating celecoxib and genistein inhibiting COX-2 pathway and Glut-1 receptors to prevent prostate cancer cell proliferation.	Genistein	54-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
30968885-1	2019	A photoactive, hetero-metallic CoII/RuII-based metal-organic framework (MOF) with a large channel aperture, ca.	Metals	22-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-35
31049429-0	2019	Corrigendum to "Naturally occurring sesquiterpene lactones and their semi-synthetic derivatives modulate PGE2 levels by decreasing COX2 activity and expression" [Heliyon 5 (3) (March 2019) e01366].	sesquiterpene lactones	36-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-135
31049429-0	2019	Corrigendum to "Naturally occurring sesquiterpene lactones and their semi-synthetic derivatives modulate PGE2 levels by decreasing COX2 activity and expression" [Heliyon 5 (3) (March 2019) e01366].	Dinoprostone	105-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-135
31016555-7	2019	RESULTS: Results show that emissions from the agriculture sector in the BAU will increase from 45.3 MtCO2eq in 2015 to 63.6 MtCO2eq in 2050, whereas net emission from the AFOLU will be 8.3 MtCO2eq in 2015 and 24.6 MtCO2eq in 2050.	Carbon	72-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-105
30968885-5	2019	In addition to the optical attributes, the 1H-imidazo [4,5-f][1,10]-phenanthroline ligand imparts structural functionality to the MOF which is composed of alternating CoII- and RuII-based nodes of Delta and Lambda helicity.	1H-imidazo(4,5-f)(1,10)phenanthroline	43-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	167-171
31016555-7	2019	RESULTS: Results show that emissions from the agriculture sector in the BAU will increase from 45.3 MtCO2eq in 2015 to 63.6 MtCO2eq in 2050, whereas net emission from the AFOLU will be 8.3 MtCO2eq in 2015 and 24.6 MtCO2eq in 2050.	Carbon	72-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	124-129
31010106-11	2019	The levels of IL-8, C reactive protein (CRP), and cyclooxygenase (COX)-2 increased only after exposure to I-PM2.5.	i-pm2	106-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-72
30991684-5	2019	In accordance to our predictions the derivatives proposed here had the potential capacity for COX-2 inhibition in the human and mice enzyme, due to containing similar interactions with the control compound (ibuprofen).	Ibuprofen	207-216	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-99
30938722-5	2019	In vitro, NOB treatment completely suppressed the overproduction of pro-inflammatory mediators, including PGE2, NO, COX-2, iNOS, TNF-alpha and IL-6 in IL-1beta-induced human OA chondrocytes.	nobiletin	10-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-121
31019986-15	2019	However, celecoxib (a selective COX-2 inhibitor) may inhibit tendon-to-bone healing in rotator cuff repair.	Celecoxib	9-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-37
30844097-2	2019	Building on the recently reported synthesis of five-membered N-heterocyclic pyrrolidines catalyzed by CoII porphyrins, the [Co(TPP)]-catalyzed formation of useful six-membered N-heterocyclic piperidines directly from linear aldehydes is presented herein.	cobalt(III)-tetrakis(4-sulfonatophenyl)porphyrin	124-131	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-106
30844097-2	2019	Building on the recently reported synthesis of five-membered N-heterocyclic pyrrolidines catalyzed by CoII porphyrins, the [Co(TPP)]-catalyzed formation of useful six-membered N-heterocyclic piperidines directly from linear aldehydes is presented herein.	Aldehydes	224-233	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-106
30932496-0	2019	Synthesis of a Neutral Mononuclear Four-Coordinate Co(II) Complex Having Two Halved Phthalocyanine Ligands That Shows Slow Magnetic Relaxations under Zero Static Magnetic Field.	phthalocyanine	84-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-57
30932496-1	2019	Syntheses of a novel pseudotetrahedral four-coordinate mononuclear Co(II) complex that has two halved phthalocyanine moieties as the ligands, [Co(half-Pc)2] (1), and its magnetic properties as a single molecule magnet (SMM) are reported.	phthalocyanine	102-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-73
30932496-2	2019	A one pot reaction of phthalonitrile and lithium methoxide followed by the coordination to a Co(II) ion gave 1 as an orange solid in a moderate yield.	1,2-benzenedicarbonitrile	22-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-99
30932496-2	2019	A one pot reaction of phthalonitrile and lithium methoxide followed by the coordination to a Co(II) ion gave 1 as an orange solid in a moderate yield.	Lithium methoxide	41-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-99
30874271-2	2019	From this ligand and a bis-bidentate nitronyl nitroxide ligand, metal complexes of MnII and CoII ions were also synthesized and characterized.	bis-bidentate nitronyl nitroxide	23-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-96
30971291-14	2019	Our study suggests that PKC/EGR1 axis, rather than COX-2, is critically involved in the inhibitory effect by iguratimod on human ASC differentiation.	iguratimod	109-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-56
30888790-0	2019	Mixed-Ligand-Architected 2D Co(II)-MOF Expressing a Novel Topology for an Efficient Photoanode for Water Oxidation Using Visible Light.	photoanode	84-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-34
30888790-0	2019	Mixed-Ligand-Architected 2D Co(II)-MOF Expressing a Novel Topology for an Efficient Photoanode for Water Oxidation Using Visible Light.	Water	99-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-34
30888790-1	2019	The structural diversity of Co(II) metal centers is known to influence their physicochemical properties.	Metals	35-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-34
30888790-2	2019	A novel two-dimensional (2D) Co(II)-MOF {[Co5(HL)4(dpp)2(H2O)2(mu-OH)2] 21H2O} n has been designed and synthesized by adopting a mixed-ligand strategy, using 1,3-di(4-pyridyl)propane (dpp) colinker with a flexible spacer H3L (H3L: 5-(2 carboxybenzyloxy)isophthalic acid).	{[co5(hl)4(dpp)2(h2o)2	40-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-35
30888790-2	2019	A novel two-dimensional (2D) Co(II)-MOF {[Co5(HL)4(dpp)2(H2O)2(mu-OH)2] 21H2O} n has been designed and synthesized by adopting a mixed-ligand strategy, using 1,3-di(4-pyridyl)propane (dpp) colinker with a flexible spacer H3L (H3L: 5-(2 carboxybenzyloxy)isophthalic acid).	(mu-oh)2] 21h2o} n	62-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-35
30888790-2	2019	A novel two-dimensional (2D) Co(II)-MOF {[Co5(HL)4(dpp)2(H2O)2(mu-OH)2] 21H2O} n has been designed and synthesized by adopting a mixed-ligand strategy, using 1,3-di(4-pyridyl)propane (dpp) colinker with a flexible spacer H3L (H3L: 5-(2 carboxybenzyloxy)isophthalic acid).	1,3-bis(4-pyridyl)propane	158-182	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-35
30888790-2	2019	A novel two-dimensional (2D) Co(II)-MOF {[Co5(HL)4(dpp)2(H2O)2(mu-OH)2] 21H2O} n has been designed and synthesized by adopting a mixed-ligand strategy, using 1,3-di(4-pyridyl)propane (dpp) colinker with a flexible spacer H3L (H3L: 5-(2 carboxybenzyloxy)isophthalic acid).	dpp	51-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-35
30888790-2	2019	A novel two-dimensional (2D) Co(II)-MOF {[Co5(HL)4(dpp)2(H2O)2(mu-OH)2] 21H2O} n has been designed and synthesized by adopting a mixed-ligand strategy, using 1,3-di(4-pyridyl)propane (dpp) colinker with a flexible spacer H3L (H3L: 5-(2 carboxybenzyloxy)isophthalic acid).	h3l	221-224	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-35
30888790-2	2019	A novel two-dimensional (2D) Co(II)-MOF {[Co5(HL)4(dpp)2(H2O)2(mu-OH)2] 21H2O} n has been designed and synthesized by adopting a mixed-ligand strategy, using 1,3-di(4-pyridyl)propane (dpp) colinker with a flexible spacer H3L (H3L: 5-(2 carboxybenzyloxy)isophthalic acid).	h3l	226-229	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-35
30874271-2	2019	From this ligand and a bis-bidentate nitronyl nitroxide ligand, metal complexes of MnII and CoII ions were also synthesized and characterized.	Metals	64-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-96
30888790-2	2019	A novel two-dimensional (2D) Co(II)-MOF {[Co5(HL)4(dpp)2(H2O)2(mu-OH)2] 21H2O} n has been designed and synthesized by adopting a mixed-ligand strategy, using 1,3-di(4-pyridyl)propane (dpp) colinker with a flexible spacer H3L (H3L: 5-(2 carboxybenzyloxy)isophthalic acid).	5-(2-Carboxybenzyloxy)isophthalic acid	231-269	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-35
30689999-1	2019	Nimesulide is a relatively selective cyclooxygenase (COX)-2 inhibitor, non-steroidal anti-inflammatory drug; it has been discovered in 1971 and firstly commercialized in Italy in 1985.	nimesulide	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-59
30888790-5	2019	The functional utility of Co(II)-MOF is demonstrated by employing it toward oxygen evolution reaction (OER) in a photoelectrochemical cell, exhibiting appreciable photocurrents of up to 5.89 mA/cm2 when used as an anode in a photoelectrochemical cell, while also displaying encouraging electrocatalytic currents of 9.32 mA/cm2 (at 2.01 V vs RHE) for the OER.	Oxygen	76-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-32
30962532-8	2019	In addition, the OTR-As significantly suppressed PGF2alpha-induced activation of pro-inflammatory pathways such as NF-kappaB and mitogen activated protein kinases (MAPKs), and the subsequent expression of contraction-associated-protein, COX-2.	Dinoprost	49-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	237-242
30959857-7	2019	Different polysaccharide-rich extracts showed the ability to inhibit pro-inflammatory enzymes (COX-1, COX-2, hyaluronidase), a radical scavenging effect (against DPPH  and ABTS +), and antiproliferative activity (in the A549 lung and SW480 colon cancer cell lines) in in vitro assays.	Polysaccharides	10-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-107
30689999-2	2019	There is much evidence that the pharmacological profile of nimesulide is peculiar and not shared with the other COX-2 selective inhibitors, suggesting that other molecular mechanisms besides inhibition of COX-2 derived prostaglandins are involved.	nimesulide	59-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	205-210
30784938-9	2019	Results showed that the anti-senescence effect of CAE was abrogated when COX-2 was knocked down or inhibited by COX-2 inhibitor NS-398 or indomethacin in lung fibroblasts.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	128-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-78
30789669-9	2019	Additionally, LH supplementation significantly downregulated the mRNA expression of nuclear factor (NF)-kappaB, cyclooxygenase-2 (COX-2), and proinflammatory cytokines (TNF-alpha, IL-1beta, and IL-6) and upregulated the mRNA expression of zonula occludens-1 (ZO-1) and Occludin in the jejunal mucosa induced by LPS (P &lt; 0.05).	Luteinizing Hormone	14-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	130-135
30456590-7	2019	Presence of EGCG (50 and 100 muM) showed significant downregulation of PI3K/Akt/mTOR and AMPK signaling along with the suppression of ROS, iNOS, Cox-2, NF-kappaB, SASP and p53 mediated cell cycle inhibition in preadipocytes.	epigallocatechin gallate	12-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-150
30807897-0	2019	Pyrazoles containing thiophene, thienopyrimidine and thienotriazolopyrimidine as COX-2 selective inhibitors: Design, synthesis, in vivo anti-inflammatory activity, docking and in silico chemo-informatic studies.	Pyrazoles	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-86
30784938-9	2019	Results showed that the anti-senescence effect of CAE was abrogated when COX-2 was knocked down or inhibited by COX-2 inhibitor NS-398 or indomethacin in lung fibroblasts.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	128-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-117
30807897-0	2019	Pyrazoles containing thiophene, thienopyrimidine and thienotriazolopyrimidine as COX-2 selective inhibitors: Design, synthesis, in vivo anti-inflammatory activity, docking and in silico chemo-informatic studies.	thienotriazolopyrimidine	53-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-86
30784938-9	2019	Results showed that the anti-senescence effect of CAE was abrogated when COX-2 was knocked down or inhibited by COX-2 inhibitor NS-398 or indomethacin in lung fibroblasts.	Indomethacin	138-150	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-78
30807897-1	2019	New thiophene and annulated thiophene pyrazole hybrids were synthesized and screened for their in vitro COX-1/COX-2 enzymatic inhibition and in vivo anti-inflammatory activities.	thiophene pyrazole	28-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-115
30878890-2	2019	Compounds 3b-g exhibited superior inhibitory activity than celecoxib as COX-2 inhibitors.	Celecoxib	59-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
30807897-6	2019	Docking studies into COX-2 active site (PDB code 3LN1) revealed that compounds 3, 6a, 6c, 9, 10, 11 and 13 had binding modes and energies comparable to that of celecoxib.	Celecoxib	160-169	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-26
30807897-9	2019	Therefore, the thiophene analog 3 and the thienopyrimidine derivatives 10 and 11 are promising anti-inflammatory candidates that exert moderate selective COX-2 inhibition with acceptable physicochemical properties.	Thiophenes	15-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	154-159
30807897-9	2019	Therefore, the thiophene analog 3 and the thienopyrimidine derivatives 10 and 11 are promising anti-inflammatory candidates that exert moderate selective COX-2 inhibition with acceptable physicochemical properties.	thienopyrimidine	42-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	154-159
30878890-0	2019	Novel aryl carboximidamide and 3-aryl-1,2,4-oxadiazole analogues of naproxen as dual selective COX-2/15-LOX inhibitors: Design, synthesis and docking studies.	aryl carboximidamide	6-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-100
30878890-0	2019	Novel aryl carboximidamide and 3-aryl-1,2,4-oxadiazole analogues of naproxen as dual selective COX-2/15-LOX inhibitors: Design, synthesis and docking studies.	3-aryl-1,2,4-oxadiazole	31-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-100
30878890-0	2019	Novel aryl carboximidamide and 3-aryl-1,2,4-oxadiazole analogues of naproxen as dual selective COX-2/15-LOX inhibitors: Design, synthesis and docking studies.	Naproxen	68-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-100
30878890-3	2019	Compounds 3b-d and 3g were the most potent COX-2 inhibitors with IC50 range of 6.4 - 8.13 nM and higher selectivity indexes (3b, SI = 26.19; 3c, SI = 13.73; 3d, SI = 29.27; 3g, SI = 18.00) comparing to celecoxib (IC50 = 42.60 nM, SI = 8.05).	Celecoxib	202-211	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
30878890-5	2019	Data revealed that The levels of NO released by aryl carboximidamides 3b-g were more higher than 3-aryl-1,2,4-oxadiazole derivatives 4b-g, which correlated well with their COX-2 inhibitory activities.	aryl carboximidamides 3b-g	48-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	172-177
30878890-5	2019	Data revealed that The levels of NO released by aryl carboximidamides 3b-g were more higher than 3-aryl-1,2,4-oxadiazole derivatives 4b-g, which correlated well with their COX-2 inhibitory activities.	3-aryl-1,2,4-oxadiazole	97-120	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	172-177
30878890-5	2019	Data revealed that The levels of NO released by aryl carboximidamides 3b-g were more higher than 3-aryl-1,2,4-oxadiazole derivatives 4b-g, which correlated well with their COX-2 inhibitory activities.	4b-g	133-137	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	172-177
30724472-0	2019	Efficient Fe-Co-N-C Electrocatalyst Towards Oxygen Reduction Derived from a Cationic CoII -based Metal-Organic Framework Modified by Anion-Exchange with Potassium Ferricyanide.	fe-co-n-c	10-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-89
30724472-0	2019	Efficient Fe-Co-N-C Electrocatalyst Towards Oxygen Reduction Derived from a Cationic CoII -based Metal-Organic Framework Modified by Anion-Exchange with Potassium Ferricyanide.	Oxygen	44-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-89
30609183-6	2019	BPA was identified to increase the expression of proinflammatory mediators NO and PGE2, and its upstream factors iNOS, COX2, and cPLA2 in a concentration-dependent manner (P &lt; 0.05).	bisphenol A	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-123
30724472-0	2019	Efficient Fe-Co-N-C Electrocatalyst Towards Oxygen Reduction Derived from a Cationic CoII -based Metal-Organic Framework Modified by Anion-Exchange with Potassium Ferricyanide.	Metals	97-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-89
30724472-0	2019	Efficient Fe-Co-N-C Electrocatalyst Towards Oxygen Reduction Derived from a Cationic CoII -based Metal-Organic Framework Modified by Anion-Exchange with Potassium Ferricyanide.	potassium ferricyanide	153-175	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-89
30724472-2	2019	Herein, we report on a unique strategy to prepare Fe-Co-N-C-x (x refers to the pyrolysis temperature) electrocatalysts which involves anion-exchange of [Fe(CN)6 ]3- into a cationic CoII -based metal-organic framework precursor prior to heat treatment.	fe-co	50-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	181-185
30724472-2	2019	Herein, we report on a unique strategy to prepare Fe-Co-N-C-x (x refers to the pyrolysis temperature) electrocatalysts which involves anion-exchange of [Fe(CN)6 ]3- into a cationic CoII -based metal-organic framework precursor prior to heat treatment.	Nitrogen	56-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	181-185
30724472-2	2019	Herein, we report on a unique strategy to prepare Fe-Co-N-C-x (x refers to the pyrolysis temperature) electrocatalysts which involves anion-exchange of [Fe(CN)6 ]3- into a cationic CoII -based metal-organic framework precursor prior to heat treatment.	Metals	193-198	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	181-185
30724472-4	2019	This is the first example of Fe-Co-N-C electrocatalysts fabricated from a cationic CoII -based MOF precursor that dopes the Fe element via anion-exchange, and our current work provides a new entrance towards MOF-derived transition-metal (e.g. Fe or Co) and nitrogen-codoped carbon electrocatalysts with excellent ORR activity.	fe-co-n-c	29-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-87
30724472-4	2019	This is the first example of Fe-Co-N-C electrocatalysts fabricated from a cationic CoII -based MOF precursor that dopes the Fe element via anion-exchange, and our current work provides a new entrance towards MOF-derived transition-metal (e.g. Fe or Co) and nitrogen-codoped carbon electrocatalysts with excellent ORR activity.	dioleoyl phosphatidylethanolamine	114-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-87
30724472-4	2019	This is the first example of Fe-Co-N-C electrocatalysts fabricated from a cationic CoII -based MOF precursor that dopes the Fe element via anion-exchange, and our current work provides a new entrance towards MOF-derived transition-metal (e.g. Fe or Co) and nitrogen-codoped carbon electrocatalysts with excellent ORR activity.	Iron	29-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-87
30724472-4	2019	This is the first example of Fe-Co-N-C electrocatalysts fabricated from a cationic CoII -based MOF precursor that dopes the Fe element via anion-exchange, and our current work provides a new entrance towards MOF-derived transition-metal (e.g. Fe or Co) and nitrogen-codoped carbon electrocatalysts with excellent ORR activity.	Metals	231-236	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-87
30724472-4	2019	This is the first example of Fe-Co-N-C electrocatalysts fabricated from a cationic CoII -based MOF precursor that dopes the Fe element via anion-exchange, and our current work provides a new entrance towards MOF-derived transition-metal (e.g. Fe or Co) and nitrogen-codoped carbon electrocatalysts with excellent ORR activity.	Iron	124-126	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-87
30724472-4	2019	This is the first example of Fe-Co-N-C electrocatalysts fabricated from a cationic CoII -based MOF precursor that dopes the Fe element via anion-exchange, and our current work provides a new entrance towards MOF-derived transition-metal (e.g. Fe or Co) and nitrogen-codoped carbon electrocatalysts with excellent ORR activity.	Cobalt	32-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-87
30724472-4	2019	This is the first example of Fe-Co-N-C electrocatalysts fabricated from a cationic CoII -based MOF precursor that dopes the Fe element via anion-exchange, and our current work provides a new entrance towards MOF-derived transition-metal (e.g. Fe or Co) and nitrogen-codoped carbon electrocatalysts with excellent ORR activity.	Nitrogen	257-265	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-87
30724472-4	2019	This is the first example of Fe-Co-N-C electrocatalysts fabricated from a cationic CoII -based MOF precursor that dopes the Fe element via anion-exchange, and our current work provides a new entrance towards MOF-derived transition-metal (e.g. Fe or Co) and nitrogen-codoped carbon electrocatalysts with excellent ORR activity.	Carbon	274-280	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-87
30732787-5	2019	Co(II)-chelated CEC cryogels have been used for fabrication of Co(II) ferrocyanide-containing composite with the distribution coefficient for 137Cs of 140,000 ml/g and the adsorption capacity of ~1 mmol/g.	hexacyanoferrate II	70-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
30732787-5	2019	Co(II)-chelated CEC cryogels have been used for fabrication of Co(II) ferrocyanide-containing composite with the distribution coefficient for 137Cs of 140,000 ml/g and the adsorption capacity of ~1 mmol/g.	hexacyanoferrate II	70-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
30669066-0	2019	Syntheses, crystal structures and biological evaluation of two new Cu(II) and Co(II) complexes based on (E)-2-(((4H-1,2,4-triazol-4-yl)imino)methyl)-6-methoxyphenol.	cu(ii)	67-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-84
30887809-0	2019	Space Craft-like Octanuclear Co(II)-Silsesquioxane Nanocages: Synthesis, Structure, Magnetic Properties, Solution Behavior, and Catalytic Activity for Hydroboration of Ketones.	Ketones	168-175	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-35
30887809-1	2019	Two novel space craft-like octanuclear Co(II)-silsesquioxane nanocages, {Co8[(MeSiO2)4]2(dmpz)8} (SD/Co8a) and {Co8[(PhSiO2)4]2(dmpz)8} (SD/Co8b) (SD = SunDi; Hdmpz = 3,5-dimethylpyrazole), have been constructed from two similar multidentate silsesquioxane ligands assisted with a pyrazole ligand.	silsesquioxane	46-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-45
30887809-2	2019	The Co8 skeleton consists of eight tetrahedral Co(II) ions arranged in a ring and is further capped by two (MeSiO2)4 ligands up and down.	COS 8 preparation	4-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-53
29697018-4	2019	In addition, computational studies of three structurally different stilbenoid derivatives used as selective COX-1 or COX-2 inhibitors were undertaken to predict their COX selectivity potentials.	stilbenoid	67-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-122
30826660-1	2019	BACKGROUND: Prostaglandin-endoperoxide synthase 2 (PTGS2, cyclooxygenase-2, COX-2)-prostaglandin E2 (PGE2) pathway promotes tumour progression.	Dinoprostone	83-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-81
30826660-1	2019	BACKGROUND: Prostaglandin-endoperoxide synthase 2 (PTGS2, cyclooxygenase-2, COX-2)-prostaglandin E2 (PGE2) pathway promotes tumour progression.	Dinoprostone	101-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-81
30669066-0	2019	Syntheses, crystal structures and biological evaluation of two new Cu(II) and Co(II) complexes based on (E)-2-(((4H-1,2,4-triazol-4-yl)imino)methyl)-6-methoxyphenol.	(e)-2-(((4h-1,2,4-triazol-4-yl)imino)methyl)-6-methoxyphenol	104-164	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-84
30918270-10	2019	Additionally, we also predicted the mechanism of action of the copper complexes 1-3 using molecular modeling studies with COX-2 inhibitor.	Copper	63-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-127
31406516-5	2019	Cox-2 generally mediates elevations of prostaglandins associated with inflammation, pain, and pyresis.	Prostaglandins	39-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
30976671-0	2019	Naturally occurring sesquiterpene lactones and their semi-synthetic derivatives modulate PGE2 levels by decreasing COX2 activity and expression.	sesquiterpene lactones	20-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-119
30976671-0	2019	Naturally occurring sesquiterpene lactones and their semi-synthetic derivatives modulate PGE2 levels by decreasing COX2 activity and expression.	Dinoprostone	89-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-119
30668316-8	2019	RESULTS: The results showed that terpenes have promising biological effects in relation to the treatment of arthritis, with the 24 terpenes identified in our survey being effective in the modulation of inflammatory mediators important to the physiopathology of arthritis, such as IL-6, IL-17, TNF-alpha, NFkappaB, and COX-2, among others.	Terpenes	131-139	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	318-323
30931980-2	2019	Increased synthesis of PGE2 in CRC has been shown to occur through COX-2-dependent mechanisms; however, loss of the PGE2-catabolizing enzyme, 15-hydroxyprostaglandin dehydrogenase (15-PGDH, HPGD), in colonic tumors contributes to increased prostaglandin levels and poor patient survival.	Dinoprostone	23-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-72
30502207-5	2019	The structure-activity relationships suggested that flavonoids O-glycosides displayed comparable binding affinities to COX-2 compared with flavonoids C-glycosides and could be considered as the main active components.	Flavonoids	52-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-124
30502207-5	2019	The structure-activity relationships suggested that flavonoids O-glycosides displayed comparable binding affinities to COX-2 compared with flavonoids C-glycosides and could be considered as the main active components.	o-glycosides	63-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-124
30918241-16	2019	CONCLUSIONS Sufentanil stimulation triggers downregulation of inflammatory factors such as HIF-1alpha, TNF-alpha, IL-1ss, and IL-6, possibly through suppressing the p38/ERK/JNK/NF-kappaB-p65/COX2 pathways, and thereby reduces the damage to IR hepatic cells.	Sufentanil	12-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	191-195
32257876-11	2020	Again, oxyresveratrol at both concentrations could significantly inhibit PGE2 production by 50-92% but it inhibited COX-2 only at high concentration.	puag-haad	7-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-121
30971955-11	2019	Treatment with gliclazide 10 mg/kg reduced MPO activity (p &lt; 0.001), MDA levels (p &lt; 0.001) and NFkappaB NLS P50 (p &lt; 0.05) protein levels, resulting in low immunostaining to Cox-2, iNOS (p &lt; 0.05), NFkappaB P65 (p &lt; 0.05), and negative immunoreaction to MMP-2 (p &lt; 0.001).	Gliclazide	15-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	184-189
30941311-0	2019	Investigating the Connection Between Endogenous Heme Accumulation and COX2 Activity in Cancer Cells.	Heme	48-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-74
30984165-1	2019	Fibroblasts play an important role as members of the innate immune system through the secretion of COX-2-derived inflammatory mediators such as prostaglandin E2 (PGE2).	Dinoprostone	144-160	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-104
30984165-1	2019	Fibroblasts play an important role as members of the innate immune system through the secretion of COX-2-derived inflammatory mediators such as prostaglandin E2 (PGE2).	Dinoprostone	162-166	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-104
30984165-4	2019	Our results indicate that under inflammatory conditions, psoriatic fibroblasts showed defective induction of COX-2, which resulted in diminished production of PGE2, in contrast to healthy fibroblasts.	Dinoprostone	159-163	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-114
30894570-11	2019	Overall, our findings uncover an important role for the COX-2/PGE2/EP4 signaling axis in oxaliplatin resistance via regulation of oxidative stress.	Dinoprostone	62-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-61
30894570-11	2019	Overall, our findings uncover an important role for the COX-2/PGE2/EP4 signaling axis in oxaliplatin resistance via regulation of oxidative stress.	Oxaliplatin	89-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-61
30835450-0	2019	Slow Magnetic Relaxation of Co(II) Single Chains Embedded within Metal-Organic Superstructures.	Metals	65-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
30835450-2	2019	The compounds feature 2D and 3D metal-organic networks that encapsulate Co(II)-based chains in a rigid superstructure.	Metals	32-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
30835450-4	2019	These Co(II)-containing coordination polymers exhibit slow magnetic relaxation, as observed by ac susceptibility measurements.	Polymers	37-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	6-13
30580142-4	2019	Capturing cobalt (Co(II)) from filtered river water doped with competing metals (Cu, As, Ag, Cd, Hg, Tl, and Pb) was most effective from pH 5-8 with binding affinity ranged from IDAA &gt; DE4A &gt; ED3A &gt; Ac-Phos &gt; SH on SAMMS.	Cobalt	10-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-24
30674535-0	2019	An ARC-Regulated IL1beta/Cox-2/PGE2/beta-Catenin/ARC Circuit Controls Leukemia-Microenvironment Interactions and Confers Drug Resistance in AML.	Dinoprostone	31-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-30
30580142-4	2019	Capturing cobalt (Co(II)) from filtered river water doped with competing metals (Cu, As, Ag, Cd, Hg, Tl, and Pb) was most effective from pH 5-8 with binding affinity ranged from IDAA &gt; DE4A &gt; ED3A &gt; Ac-Phos &gt; SH on SAMMS.	Water	46-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-24
30580142-4	2019	Capturing cobalt (Co(II)) from filtered river water doped with competing metals (Cu, As, Ag, Cd, Hg, Tl, and Pb) was most effective from pH 5-8 with binding affinity ranged from IDAA &gt; DE4A &gt; ED3A &gt; Ac-Phos &gt; SH on SAMMS.	Copper	81-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-24
30580142-4	2019	Capturing cobalt (Co(II)) from filtered river water doped with competing metals (Cu, As, Ag, Cd, Hg, Tl, and Pb) was most effective from pH 5-8 with binding affinity ranged from IDAA &gt; DE4A &gt; ED3A &gt; Ac-Phos &gt; SH on SAMMS.	Arsenic	85-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-24
30580142-4	2019	Capturing cobalt (Co(II)) from filtered river water doped with competing metals (Cu, As, Ag, Cd, Hg, Tl, and Pb) was most effective from pH 5-8 with binding affinity ranged from IDAA &gt; DE4A &gt; ED3A &gt; Ac-Phos &gt; SH on SAMMS.	Cadmium	93-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-24
30580142-4	2019	Capturing cobalt (Co(II)) from filtered river water doped with competing metals (Cu, As, Ag, Cd, Hg, Tl, and Pb) was most effective from pH 5-8 with binding affinity ranged from IDAA &gt; DE4A &gt; ED3A &gt; Ac-Phos &gt; SH on SAMMS.	Thallium	101-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-24
30580142-4	2019	Capturing cobalt (Co(II)) from filtered river water doped with competing metals (Cu, As, Ag, Cd, Hg, Tl, and Pb) was most effective from pH 5-8 with binding affinity ranged from IDAA &gt; DE4A &gt; ED3A &gt; Ac-Phos &gt; SH on SAMMS.	Lead	109-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-24
30580142-4	2019	Capturing cobalt (Co(II)) from filtered river water doped with competing metals (Cu, As, Ag, Cd, Hg, Tl, and Pb) was most effective from pH 5-8 with binding affinity ranged from IDAA &gt; DE4A &gt; ED3A &gt; Ac-Phos &gt; SH on SAMMS.	Actinium	208-210	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-24
30580142-4	2019	Capturing cobalt (Co(II)) from filtered river water doped with competing metals (Cu, As, Ag, Cd, Hg, Tl, and Pb) was most effective from pH 5-8 with binding affinity ranged from IDAA &gt; DE4A &gt; ED3A &gt; Ac-Phos &gt; SH on SAMMS.	phosphorylethanolamine	211-215	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-24
30580142-5	2019	Iminodiacetic acid (IDAA)-SAMMS was also outstanding at capturing Co(II) in ground and seawater.	iminodiacetic acid	0-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-72
30580142-5	2019	Iminodiacetic acid (IDAA)-SAMMS was also outstanding at capturing Co(II) in ground and seawater.	iminodiacetic acid	20-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-72
30802511-10	2019	Based on the shift in the omega-6/omega-3 balance towards omega-6, as well as the increase in COX-2 and TNFalpha protein expressions, we may postulate a pro-inflammatory nature of the examined polyphenol.	Polyphenols	193-203	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-99
30580142-6	2019	Within 5 min, over 99% of U(VI) and Co(II) in seawater was captured by 3,4-HOPO-SAMMS and IDAA-SAMMS, respectively.	3,4-hopo-samms	71-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-42
30580142-6	2019	Within 5 min, over 99% of U(VI) and Co(II) in seawater was captured by 3,4-HOPO-SAMMS and IDAA-SAMMS, respectively.	idaa-samms	90-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-42
31459694-1	2019	Three new multicomponent crystals 1a-1c of Zn(II), Mn(II), and Co(II), respectively, were synthesized by the reaction of 2,6-bis(hydroxymethyl)pyridine, the respective metal salts, and sodium benzoate in a 1:1:2 ratio.	2,6-bis-(hydroxymethyl)-pyridine	121-151	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-69
30767506-3	2019	Based on the strong intermolecular interactions between indomethacin (IDM, a COX-2 inhibitor) and paclitaxel (PTX, a chemotherapy drug), we herein successfully engineered a novel kind of carrier-free nanomedicines that organized as IDM-induced PTX nanocrystal aggregates via one-pot self-assembly without any nonactive excipients.	Indomethacin	56-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-82
30767506-3	2019	Based on the strong intermolecular interactions between indomethacin (IDM, a COX-2 inhibitor) and paclitaxel (PTX, a chemotherapy drug), we herein successfully engineered a novel kind of carrier-free nanomedicines that organized as IDM-induced PTX nanocrystal aggregates via one-pot self-assembly without any nonactive excipients.	Paclitaxel	98-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-82
31459694-1	2019	Three new multicomponent crystals 1a-1c of Zn(II), Mn(II), and Co(II), respectively, were synthesized by the reaction of 2,6-bis(hydroxymethyl)pyridine, the respective metal salts, and sodium benzoate in a 1:1:2 ratio.	metal salts	168-179	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-69
31459694-1	2019	Three new multicomponent crystals 1a-1c of Zn(II), Mn(II), and Co(II), respectively, were synthesized by the reaction of 2,6-bis(hydroxymethyl)pyridine, the respective metal salts, and sodium benzoate in a 1:1:2 ratio.	Sodium Benzoate	185-200	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-69
31459694-5	2019	The Mn(II) (1b) and Co(II) (1c) complexes show antiferromagnetic coupling between the two associated metal centers via the H-bonding interaction pathway.	Metals	101-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-26
30983880-0	2019	Effects of the Highly COX-2-Selective Analgesic NSAID Etoricoxib on Human Periodontal Ligament Fibroblasts during Compressive Orthodontic Mechanical Strain.	Etoricoxib	54-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-27
30972073-6	2019	Asparacosin A also inhibited the human recombinant COX-2 enzyme and caused a dose-dependent decrease in the levels of TNF-alpha, IL-1beta, and PGE2 in the carrageenan-induced paws.	asparacosin A	0-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-56
30972073-9	2019	Molecular docking was carried out on both COX-1 and COX-2 structures which revealed that Asparacosin A targets allosteric binding site similar to the binding mode of the selective COX inhibitor.	asparacosin A	89-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-57
30972073-10	2019	In conclusion, Asparacosin A exhibits anti-inflammatory and peripheral anti-nociceptive activities which are likely mediated via inhibition of COX-2 enzyme and inflammatory cytokines.	asparacosin A	15-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	143-148
30962670-4	2019	In contrast, addition of HBPin, (Pin = pinacolato) B2Pin2 and aryl halides resulted in the formation of net one-electron oxidation products: cationic Co(II)-boryl and Co(II)-halide/aryl complexes, respectively.	halides	67-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	150-156
30962670-4	2019	In contrast, addition of HBPin, (Pin = pinacolato) B2Pin2 and aryl halides resulted in the formation of net one-electron oxidation products: cationic Co(II)-boryl and Co(II)-halide/aryl complexes, respectively.	halides	67-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	167-173
30962670-4	2019	In contrast, addition of HBPin, (Pin = pinacolato) B2Pin2 and aryl halides resulted in the formation of net one-electron oxidation products: cationic Co(II)-boryl and Co(II)-halide/aryl complexes, respectively.	halide	67-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	150-156
30983880-2	2019	The highly COX-2-selective NSAID etoricoxib has a favorable systemic side effect profile and high analgesic efficacy, particularly for orthodontic pain.	Etoricoxib	33-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-16
30962670-4	2019	In contrast, addition of HBPin, (Pin = pinacolato) B2Pin2 and aryl halides resulted in the formation of net one-electron oxidation products: cationic Co(II)-boryl and Co(II)-halide/aryl complexes, respectively.	halide	67-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	167-173
30983880-10	2019	Clinically dosed etoricoxib, that is, a highly selective COX-2 inhibition, did not have substantial effects on hPDL fibroblast-mediated periodontal inflammation, extracellular matrix remodeling, RANK-L/OPG expression, and osteoclastogenesis during simulated orthodontic compressive strain.	Etoricoxib	17-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-62
30962670-6	2019	Monitoring the addition of HBPin to [(iPrPNP)Co(N2)]+ provided evidence for a transient Co(III) oxidative addition product that likely undergoes comproportionation with the cobalt(I) starting material to generate the observed Co(II) products.	iprpnp	38-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	226-232
30962670-6	2019	Monitoring the addition of HBPin to [(iPrPNP)Co(N2)]+ provided evidence for a transient Co(III) oxidative addition product that likely undergoes comproportionation with the cobalt(I) starting material to generate the observed Co(II) products.	co(iii)	88-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	226-232
30342385-0	2019	Synthesis of new pyrazoles and pyrozolo [3,4-b] pyridines as anti-inflammatory agents by inhibition of COX-2 enzyme.	Pyrazoles	17-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-108
30762343-3	2019	The Co-PNNNP pincer species readily demetallate upon reduction of CoIII to CoII, allowing for transmetalation with late second and third row transition metals in both the homogeneous complex and 1-CoCl3.	1-cocl3	195-202	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-70
30778447-1	2019	Here we show that a structure containing a polymeric interlocking daisy chain is obtained from the reaction of an inorganic-organic [2]rotaxane [HB{CrIII7NiII(mu-F)8(O2CtBu)16}], where B is an organic thread terminated with a bi-pyridyl unit, with an oxo-centered metal carboxylate triangle [FeIII2CoII(mu3-O)(O2CtBu)6(HO2CtBu)3].	Rotaxanes	135-143	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	298-302
30342385-0	2019	Synthesis of new pyrazoles and pyrozolo [3,4-b] pyridines as anti-inflammatory agents by inhibition of COX-2 enzyme.	pyrozolo [3,4-b] pyridines	31-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-108
30391698-6	2019	For compound 25, it showed about 340 and 198 times more potent than celecoxib and naproxen respectively as COX-1 inhibitor (IC50 value 0.044 vs. 15.000 and 8.700 microM), and 10 and 115 times more potent than the same drugs as COX-2 inhibitor (IC50 value 4.52 vs. 40.00 and 520.00 nM).	Celecoxib	68-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	227-232
30391698-6	2019	For compound 25, it showed about 340 and 198 times more potent than celecoxib and naproxen respectively as COX-1 inhibitor (IC50 value 0.044 vs. 15.000 and 8.700 microM), and 10 and 115 times more potent than the same drugs as COX-2 inhibitor (IC50 value 4.52 vs. 40.00 and 520.00 nM).	Naproxen	82-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	227-232
30481648-3	2019	Compounds 4b, 4d, 4h, 4l, 4n and 4o showed the best in vitro COX-2 inhibitory activity (IC50 0.04-0.07 muM), which was nearly the same as that of the reference drug celecoxib (IC50 0.049 muM), but had a lower selectivity index, as dictated in our target design.	4h	18-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-66
30776222-1	2019	The synthesis and characterization of a Co(II) dithiolato complex Co(Me3TACN)(S2SiMe2) (1) are reported.	co(me3tacn)(s2sime2)	66-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-46
30728152-3	2019	GM-CSF selectively enhanced Th9 cell differentiation by regulating the COX2-PGE2 pathway while inhibiting the differentiation of induced regulatory T (iTreg) cells in vitro and in vivo GM-CSF-activated monocyte-derived dendritic cells converted tumor-specific naive Th cells into Th9 cells, and delayed tumor growth by inducing antitumor CTLs in an IL9-dependent manner.	Dinoprostone	76-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-75
30628640-10	2019	The EC cells treated with CP-31398 or siRNA against MDM2 exhibited an increased apoptosis and a suppressed migration and invasion, corresponding to an increased expression of p53, p21, Bad, Bax, Cyt-c and caspase-3, as well as to a decreased expression of Bcl-2, Cox-2, MMP-2 and MMP-9.	CP 31398	26-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	263-268
30604480-5	2019	Meanwhile, SA could also reverse the degradation of type II collage and aggrecan, as well as the overproduction of matrix metalloproteinase-9 (MMP-9) and matrix metalloproteinase-13 (MMP-13), inducible nitric oxide synthase (iNOS), cyclooxygenase (COX)-2 and a disintegrin and metalloproteinase thrombospondin motifs (ADAMTS)-5.	sinapinic acid	11-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	232-254
31205515-7	2019	Higher expression levels of both c-Myb and COX-2 were significantly associated with shorter overall survival for stage II and stage III patients with 5-Fu based chemotherapy.	Fluorouracil	150-154	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
30818765-2	2019	meso-Tetraphenyl-porphyrin chelates (CuII, NiII, CoII) upon reaction wit e.g., itric acid (yellow HNO3, d = 1.52, diluted to 25-50%) in CHCl3 formed a mixture of nitro-derivatives with combined yields of ca 80%.	tetraphenylporphine	0-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-53
30508771-6	2019	The selectivity index (SI) range was >200-490 and was comparable to that for celecoxib [COX-2 (SI) > 416.7].	Celecoxib	77-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-93
30294891-9	2019	The high inhibition obtained for compound 10 against COX-2 was explained by hydrogen bond interactions at the enzyme binding site.	Hydrogen	76-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-58
30929580-0	2019	Potentially inappropriate concomitant medicine use with the selective COX-2 inhibitor celecoxib: Analysis and comparison of spontaneous adverse event reports from Australia, Canada and the USA.	Celecoxib	86-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-75
30818765-2	2019	meso-Tetraphenyl-porphyrin chelates (CuII, NiII, CoII) upon reaction wit e.g., itric acid (yellow HNO3, d = 1.52, diluted to 25-50%) in CHCl3 formed a mixture of nitro-derivatives with combined yields of ca 80%.	itric acid	79-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-53
30818765-2	2019	meso-Tetraphenyl-porphyrin chelates (CuII, NiII, CoII) upon reaction wit e.g., itric acid (yellow HNO3, d = 1.52, diluted to 25-50%) in CHCl3 formed a mixture of nitro-derivatives with combined yields of ca 80%.	Nitric Acid	98-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-53
30818765-2	2019	meso-Tetraphenyl-porphyrin chelates (CuII, NiII, CoII) upon reaction wit e.g., itric acid (yellow HNO3, d = 1.52, diluted to 25-50%) in CHCl3 formed a mixture of nitro-derivatives with combined yields of ca 80%.	Chloroform	136-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-53
30818884-13	2019	The p38 inhibitor SB203580 and the JNK inhibitor SP600125 suppressed MMP-9 and COX-2 expression in H2O2-treated HaCaT cells.	SB 203580	18-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-84
30818765-2	2019	meso-Tetraphenyl-porphyrin chelates (CuII, NiII, CoII) upon reaction wit e.g., itric acid (yellow HNO3, d = 1.52, diluted to 25-50%) in CHCl3 formed a mixture of nitro-derivatives with combined yields of ca 80%.	nitro	162-167	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-53
30818884-13	2019	The p38 inhibitor SB203580 and the JNK inhibitor SP600125 suppressed MMP-9 and COX-2 expression in H2O2-treated HaCaT cells.	pyrazolanthrone	49-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-84
30653946-2	2019	The current studies focus on the role of COX-2 signaling pathway in canolol-induced apoptosis in cancer cells.	4-vinyl-2,6-dimethoxyphenol	68-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-46
30818884-13	2019	The p38 inhibitor SB203580 and the JNK inhibitor SP600125 suppressed MMP-9 and COX-2 expression in H2O2-treated HaCaT cells.	Hydrogen Peroxide	99-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-84
30796531-5	2019	In the presence of AA, the CoOOH nanoflakes are reduced to Co (II), and this triggers the recovery of fluorescence.	coooh	27-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-66
30809428-11	2019	Results: Converting to RSC, LLUH reduced its annual GHG by 162.4 MTCO2eq (-65.3%; p &lt; 0.001; RR 2.27-3.71), and annually eliminated 50.2 tonnes of plastic DSC and 8.1 tonnes of cardboard from the sharps waste stream.	rsc	23-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-70
30667210-8	2019	A close inspection of crystal structures reveals that unsaturated Co(II) and Ni(II) sites adsorb both CO2 and CO, whereas the unsaturated Mg(II) sites strongly capture only CO2, not CO.	N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)-4-((4-fluorobenzyl)oxy)pyridine-2,6-dicarboxamide	102-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-72
30667210-8	2019	A close inspection of crystal structures reveals that unsaturated Co(II) and Ni(II) sites adsorb both CO2 and CO, whereas the unsaturated Mg(II) sites strongly capture only CO2, not CO.	Carbon Monoxide	102-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-72
30667210-8	2019	A close inspection of crystal structures reveals that unsaturated Co(II) and Ni(II) sites adsorb both CO2 and CO, whereas the unsaturated Mg(II) sites strongly capture only CO2, not CO.	Carbon Monoxide	110-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-72
30667210-9	2019	Density functional theory calculations elucidate the discrepancy in CO affinity: Co(II) and Ni(II) form strong pi-back-donating bonds with CO via electron transfer from the d orbitals of the transition metals to the antibonding molecular orbitals of CO, whereas Mg(II) does not participate in electron transfer or orbital overlap with CO.	mg(ii)	262-268	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-87
30650965-4	2019	In situ visible and quasi-in situ X-ray absorption spectroscopy reveal that the hydrogen-to-deuterium isotopic substitution induces an equilibrium isotope effect that shifts the oxidation potentials positively by approximately 60 mV for the proton coupled CoII/III and CoIII/IV electron transfer processes.	Hydrogen	80-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	256-260
30650965-4	2019	In situ visible and quasi-in situ X-ray absorption spectroscopy reveal that the hydrogen-to-deuterium isotopic substitution induces an equilibrium isotope effect that shifts the oxidation potentials positively by approximately 60 mV for the proton coupled CoII/III and CoIII/IV electron transfer processes.	Deuterium	92-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	256-260
30842737-13	2019	Conclusion: The study shows that naproxen partially prevents POI, probably through its inhibitory effect on COX-2 activity.	Naproxen	33-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-113
30668108-14	2019	Further reflecting the role of the ligand in tuning reactivity, the trimetallic trihydride cluster compounds, [M3(mu-H)3]3+ (M = FeII, CoII, ZnII), demonstrate substrate specificity for CO2 over various other unsaturated molecules and surprising stability toward water.	trimetallic trihydride	68-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-139
30668108-14	2019	Further reflecting the role of the ligand in tuning reactivity, the trimetallic trihydride cluster compounds, [M3(mu-H)3]3+ (M = FeII, CoII, ZnII), demonstrate substrate specificity for CO2 over various other unsaturated molecules and surprising stability toward water.	Carbon Dioxide	186-189	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-139
30668108-14	2019	Further reflecting the role of the ligand in tuning reactivity, the trimetallic trihydride cluster compounds, [M3(mu-H)3]3+ (M = FeII, CoII, ZnII), demonstrate substrate specificity for CO2 over various other unsaturated molecules and surprising stability toward water.	Water	263-268	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-139
31459576-9	2019	The thermodynamic data reveal that the interaction best suited for Al(III) ion compared to other metal ions (Al(III) &gt; Co(II) &gt; Hg(II) &gt; Cr(III)   Cr(VI)).	al(iii)	67-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-128
31459576-9	2019	The thermodynamic data reveal that the interaction best suited for Al(III) ion compared to other metal ions (Al(III) &gt; Co(II) &gt; Hg(II) &gt; Cr(III)   Cr(VI)).	Metals	97-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-128
31459576-9	2019	The thermodynamic data reveal that the interaction best suited for Al(III) ion compared to other metal ions (Al(III) &gt; Co(II) &gt; Hg(II) &gt; Cr(III)   Cr(VI)).	al(iii)	109-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-128
31459576-9	2019	The thermodynamic data reveal that the interaction best suited for Al(III) ion compared to other metal ions (Al(III) &gt; Co(II) &gt; Hg(II) &gt; Cr(III)   Cr(VI)).	Chromium	146-148	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-128
31459576-9	2019	The thermodynamic data reveal that the interaction best suited for Al(III) ion compared to other metal ions (Al(III) &gt; Co(II) &gt; Hg(II) &gt; Cr(III)   Cr(VI)).	Chromium	156-158	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-128
30694654-0	2019	Magnetic Properties of Co(II) Complexes with Polyhedral Carborane Ligands.	carborane	56-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-29
30694654-1	2019	In this work we present a computational analysis of a new family of magnetic Co(II) single-ion complexes with large magnetic anisotropy based on icosahedral and octahedral carborane ligands.	carborane	172-181	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-83
30694654-2	2019	In particular, we extend our previous computational work on mononuclear Co(II) complexes with 1,2-(HS)2-1,2-C2B10H10 and 9,12-(HS)2-1,2-C2B10H10 icosahedral o-carborane ligands to a larger set of complexes where the Co(II) ion is doubly chelated by those ligands and by other two positional isomers belonging to the 1,2-dicarba- closo-dodecaborane family.	1,2-(hs)2-1,2-c2b10h10	94-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-78
30694654-2	2019	In particular, we extend our previous computational work on mononuclear Co(II) complexes with 1,2-(HS)2-1,2-C2B10H10 and 9,12-(HS)2-1,2-C2B10H10 icosahedral o-carborane ligands to a larger set of complexes where the Co(II) ion is doubly chelated by those ligands and by other two positional isomers belonging to the 1,2-dicarba- closo-dodecaborane family.	hs)2	99-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-78
30694654-2	2019	In particular, we extend our previous computational work on mononuclear Co(II) complexes with 1,2-(HS)2-1,2-C2B10H10 and 9,12-(HS)2-1,2-C2B10H10 icosahedral o-carborane ligands to a larger set of complexes where the Co(II) ion is doubly chelated by those ligands and by other two positional isomers belonging to the 1,2-dicarba- closo-dodecaborane family.	,2-c2b10h10	105-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-78
30694654-2	2019	In particular, we extend our previous computational work on mononuclear Co(II) complexes with 1,2-(HS)2-1,2-C2B10H10 and 9,12-(HS)2-1,2-C2B10H10 icosahedral o-carborane ligands to a larger set of complexes where the Co(II) ion is doubly chelated by those ligands and by other two positional isomers belonging to the 1,2-dicarba- closo-dodecaborane family.	o-Carborane	157-168	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-78
30694654-2	2019	In particular, we extend our previous computational work on mononuclear Co(II) complexes with 1,2-(HS)2-1,2-C2B10H10 and 9,12-(HS)2-1,2-C2B10H10 icosahedral o-carborane ligands to a larger set of complexes where the Co(II) ion is doubly chelated by those ligands and by other two positional isomers belonging to the 1,2-dicarba- closo-dodecaborane family.	dodecaborate	316-347	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-78
30694654-3	2019	We also describe Co(II) complexes with octahedral ligands derived from 1,2-dicarba- closo-hexaborane and study the effects of replacing a thiol group by a hydroxy group in both polyhedral geometries, as well as the influence of the position of the carbon atoms.	1,2-dicarba- closo-hexaborane	71-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-23
30694654-3	2019	We also describe Co(II) complexes with octahedral ligands derived from 1,2-dicarba- closo-hexaborane and study the effects of replacing a thiol group by a hydroxy group in both polyhedral geometries, as well as the influence of the position of the carbon atoms.	Carbon	248-254	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-23
30694654-4	2019	On analysis of the results for a total of 20 complexes, our results show that carborane-based Co(II) single-ion compounds present a distorted-tetrahedral geometry, high-spin ground states, and high values for the magnetic anisotropy parameters.	carborane	78-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-100
30737317-9	2019	Nonsteroidal anti-inflammatory drugs (e.g. aspirin, ibuprofen, and naproxen) block PG synthesis by inhibiting COX-1 and COX-2.	Aspirin	43-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-125
30737317-9	2019	Nonsteroidal anti-inflammatory drugs (e.g. aspirin, ibuprofen, and naproxen) block PG synthesis by inhibiting COX-1 and COX-2.	Ibuprofen	52-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-125
30737317-9	2019	Nonsteroidal anti-inflammatory drugs (e.g. aspirin, ibuprofen, and naproxen) block PG synthesis by inhibiting COX-1 and COX-2.	Naproxen	67-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-125
30737317-9	2019	Nonsteroidal anti-inflammatory drugs (e.g. aspirin, ibuprofen, and naproxen) block PG synthesis by inhibiting COX-1 and COX-2.	Prostaglandins	83-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-125
30739202-2	2019	The resulting metal-organic gel (MOG) shows enhanced peroxidase-like activity, most likely due to the synergetic redox cycling between Co(III)/Co(II) and Cu(II)/Cu(I) pairs.	Metals	14-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	143-149
30739202-9	2019	Graphical abstracts Schematic presentation of the synergic catalytic effect of Cu(II)/Co(II) bimetallic organic gel promoted by the redox cycle between Co(III)/Co(II) and Cu(II)/Cu(I) pairs.	cu(ii)	79-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-92
30739202-9	2019	Graphical abstracts Schematic presentation of the synergic catalytic effect of Cu(II)/Co(II) bimetallic organic gel promoted by the redox cycle between Co(III)/Co(II) and Cu(II)/Cu(I) pairs.	cu(ii)	79-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	160-166
30739202-9	2019	Graphical abstracts Schematic presentation of the synergic catalytic effect of Cu(II)/Co(II) bimetallic organic gel promoted by the redox cycle between Co(III)/Co(II) and Cu(II)/Cu(I) pairs.	cu(ii)	171-177	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-92
30739202-9	2019	Graphical abstracts Schematic presentation of the synergic catalytic effect of Cu(II)/Co(II) bimetallic organic gel promoted by the redox cycle between Co(III)/Co(II) and Cu(II)/Cu(I) pairs.	cu(ii)	171-177	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	160-166
30739202-9	2019	Graphical abstracts Schematic presentation of the synergic catalytic effect of Cu(II)/Co(II) bimetallic organic gel promoted by the redox cycle between Co(III)/Co(II) and Cu(II)/Cu(I) pairs.	cuprous ion	178-183	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-92
30739202-9	2019	Graphical abstracts Schematic presentation of the synergic catalytic effect of Cu(II)/Co(II) bimetallic organic gel promoted by the redox cycle between Co(III)/Co(II) and Cu(II)/Cu(I) pairs.	cuprous ion	178-183	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	160-166
30675786-1	2019	Chiral coordination compounds of Co(II) and other open-shell metal complexes display enhanced vibrational circular dichroism (VCD) spectra associated with the existence of low-lying excited states (LLESs).	Metals	61-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-39
31007578-2	2019	In this study, the catalytic activity of well-characterized CoII and CoI complexes of the pToldpbp ligand is demonstrated in the hydrosilylation of 1-octene with phenylsilane.	1-octene	148-156	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-64
31007578-2	2019	In this study, the catalytic activity of well-characterized CoII and CoI complexes of the pToldpbp ligand is demonstrated in the hydrosilylation of 1-octene with phenylsilane.	Phenylsilane	162-174	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-64
30602073-6	2019	Herein we report the synthesis of three carborane-containing derivatives of the COX-2-selective NSAID celecoxib.	carborane	40-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-85
30602073-6	2019	Herein we report the synthesis of three carborane-containing derivatives of the COX-2-selective NSAID celecoxib.	Celecoxib	102-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-85
31139556-3	2019	While inducing cancer cell death, chemodrugs enhance cancer stemness, invasiveness, and drug resistance of remaining cancer cells through upregulating cyclooxygenase-2/prostaglandin-E2 (COX-2/PGE2) signaling, therefore facilitating cancer repopulation and relapse.	Dinoprostone	168-184	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	186-191
31139556-6	2019	Celecoxib, an FDA-approved COX-2 inhibitor, is employed as a structural and functional element to confer MSCPs with redox-responsiveness and COX-2/PGE2 inhibitory activity.	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-32
31139556-6	2019	Celecoxib, an FDA-approved COX-2 inhibitor, is employed as a structural and functional element to confer MSCPs with redox-responsiveness and COX-2/PGE2 inhibitory activity.	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	141-146
31139556-8	2019	Importantly, through blocking chemotherapy-activated COX-2/PGE2 signaling, MSCPs drastically enhance DOX"s antitumor activity by suppressing enhancement of cancer stemness and invasiveness as well as drug resistance induced by DOX-based chemotherapy in vitro.	Doxorubicin	101-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-58
31139556-8	2019	Importantly, through blocking chemotherapy-activated COX-2/PGE2 signaling, MSCPs drastically enhance DOX"s antitumor activity by suppressing enhancement of cancer stemness and invasiveness as well as drug resistance induced by DOX-based chemotherapy in vitro.	Doxorubicin	227-230	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-58
31139556-10	2019	DOX-loaded MSCPs effectively inhibit tumor repopulation by blocking COX-2/PGE2 signaling, which eliminates DOX-induced expansion of cancer stem-like cells, distant metastasis, and acquired drug resistance.	Doxorubicin	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-73
31139556-10	2019	DOX-loaded MSCPs effectively inhibit tumor repopulation by blocking COX-2/PGE2 signaling, which eliminates DOX-induced expansion of cancer stem-like cells, distant metastasis, and acquired drug resistance.	Doxorubicin	107-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-73
30278282-0	2019	Design, synthesis, modeling studies and biological evaluation of thiazolidine derivatives containing pyrazole core as potential anti-diabetic PPAR-gamma agonists and anti-inflammatory COX-2 selective inhibitors.	Thiazolidines	65-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	184-189
30278282-6	2019	(8.69-9.26) than the COX-2 selective drug celecoxib (COX-2 S.I.	Celecoxib	42-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-26
30381825-3	2019	However, an inducible COX isoform, COX-2, is often highly expressed in tissues of the chronic disorders, suggesting an as yet unidentified role of PGs in chronic inflammation.	Phosphatidylglycerols	147-150	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40
30381825-7	2019	Typically, PGs and cytokines synergistically activate NF-kappaB to induce the expression of inflammation-related genes, one being COX-2 itself, which makes PG-mediated positive feedback loops.	Phosphatidylglycerols	11-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	130-135
30381825-7	2019	Typically, PGs and cytokines synergistically activate NF-kappaB to induce the expression of inflammation-related genes, one being COX-2 itself, which makes PG-mediated positive feedback loops.	Prostaglandins	11-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	130-135
30868497-0	2019	Efficacy and Safety of COX-2 Inhibitor Parecoxib for Rigid Cystoscopy-related Pain Management in Male Patients: A Prospective, Randomized and Controlled Study.	parecoxib	39-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-28
29728874-10	2019	The results obtained by in vitro cell line study, histopathological and biochemical data concluded that nimesulide, a preferential COX-2 inhibitor, has anticancer activity, which is by first reducing the formation of reactive oxygen species and second by inhibiting the PGE2 effect via Wnt signaling pathway (cell invasion, angiogenesis, and cell proliferation).	nimesulide	104-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-136
30552915-4	2019	We found that resveratrol up-regulates DUSP1 expression in androgen-independent prostate cancer cells, which in turn, is involved in the inhibition of the NF-kappaB pathway and Cox-2 expression.	Resveratrol	14-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	177-182
30710016-5	2019	For example, naproxen directly and completely inhibits COX-1 by binding Ecat but indirectly and incompletely inhibits COX-2 by binding Eallo.	Naproxen	13-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-123
30710016-6	2019	Additionally, COX-1 is allosterically inhibited up to 50% by common FAs like palmitic acid, whereas COX-2 is allosterically activated 2-fold by palmitic acid.	Palmitic Acid	144-157	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-105
30710016-10	2019	Mutational studies suggest that allosteric modulation requires a direct interaction between the carboxyl group of allosteric effectors and Arg-120 of Eallo; however, structural studies show some allosterically active FAs positioned in COX-2 in a conformation lacking an interaction with Arg-120.	Arginine	287-290	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	235-240
30293044-0	2019	The effect of chelating anions on the retention of Co(II) by gamma-alumina from aqueous solutions under the unadjusted pH condition of supported catalyst preparation.	Aluminum Oxide	61-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-57
30293044-1	2019	This study analyzes the effect of the addition of acetate, citrate, and nitrilotriacetate anions on the retention of Co(II) cations by the gamma-alumina surface in view of the preparation of alumina supported cobalt catalysts.	Acetates	50-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-123
30293044-1	2019	This study analyzes the effect of the addition of acetate, citrate, and nitrilotriacetate anions on the retention of Co(II) cations by the gamma-alumina surface in view of the preparation of alumina supported cobalt catalysts.	Citric Acid	59-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-123
30293044-1	2019	This study analyzes the effect of the addition of acetate, citrate, and nitrilotriacetate anions on the retention of Co(II) cations by the gamma-alumina surface in view of the preparation of alumina supported cobalt catalysts.	Nitrilotriacetic Acid	72-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-123
30293044-1	2019	This study analyzes the effect of the addition of acetate, citrate, and nitrilotriacetate anions on the retention of Co(II) cations by the gamma-alumina surface in view of the preparation of alumina supported cobalt catalysts.	Aluminum Oxide	139-152	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-123
30293044-1	2019	This study analyzes the effect of the addition of acetate, citrate, and nitrilotriacetate anions on the retention of Co(II) cations by the gamma-alumina surface in view of the preparation of alumina supported cobalt catalysts.	Aluminum Oxide	145-152	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-123
30293044-1	2019	This study analyzes the effect of the addition of acetate, citrate, and nitrilotriacetate anions on the retention of Co(II) cations by the gamma-alumina surface in view of the preparation of alumina supported cobalt catalysts.	Cobalt	209-215	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-123
30293044-7	2019	The adsorption of Co(II) onto gamma-Al2O3 in the presence of acetate and nitrilotriacetate led to the formation of the type A (i.e., solid-metal-ligand) ternary complexes.	gamma-al2o3	30-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-24
30293044-7	2019	The adsorption of Co(II) onto gamma-Al2O3 in the presence of acetate and nitrilotriacetate led to the formation of the type A (i.e., solid-metal-ligand) ternary complexes.	Acetates	61-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-24
30293044-7	2019	The adsorption of Co(II) onto gamma-Al2O3 in the presence of acetate and nitrilotriacetate led to the formation of the type A (i.e., solid-metal-ligand) ternary complexes.	Nitrilotriacetic Acid	73-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-24
30448715-0	2019	Novel Co(II) and Cu(II) coordination complexes constructed from pyrazole-acetamide: Effect of hydrogen bonding on the self assembly process and antioxidant activity.	pyrazole-acetamide	64-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	6-12
30448715-0	2019	Novel Co(II) and Cu(II) coordination complexes constructed from pyrazole-acetamide: Effect of hydrogen bonding on the self assembly process and antioxidant activity.	Hydrogen	94-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	6-12
30584980-1	2019	We have previously demonstrated that DGLA treatment along with Delta-5-Desaturase (D5D) siRNA in various types of cancer cells enhances the formation of 8-HOA from COX-2-catalyzed DGLA peroxidation, which in turn inhibits cancer cell growth and migration.	8,11,14-Eicosatrienoic Acid	37-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	164-169
30682691-3	2019	In both cases, rupture of the CoC bond results in the formation of Co(II)/Ado radical pair (RP).	ado radical	74-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-73
30554313-6	2019	Thus, it is possible to suggest that C-PC modulates the expression of COX2 and ABCB1 for the K562-Lucena in a ROS-dependent manner and the expression of ALOX5 for the FEPS in a ROS-independent manner; however, more studies are needed to elucidate these mechanisms.	ros	110-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-74
30584980-1	2019	We have previously demonstrated that DGLA treatment along with Delta-5-Desaturase (D5D) siRNA in various types of cancer cells enhances the formation of 8-HOA from COX-2-catalyzed DGLA peroxidation, which in turn inhibits cancer cell growth and migration.	8,11,14-Eicosatrienoic Acid	180-184	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	164-169
30584980-6	2019	We further confirmed that 8-HOA formation, promoted by COX-2-catalyzed DGLA peroxidation, inhibited HDAC and consequently induced apoptosis in tumor cells.	8,11,14-Eicosatrienoic Acid	71-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-60
30696869-5	2019	Biochemical parameters were assayed and showed that the shift from normal glucose (NG; 5.5 mM) to high glucose (HG; 25 mM) promoted cell growth and induced oxidative/inflammatory stress and microglial activation, as evidenced by increased MTT reduction, elevated pro-inflammatory factor secretion (i.e., TNF-alpha and oxygen free radicals), and upregulated expression of stress/inflammatory proteins (i.e., HSP70, HO-1, iNOS, and COX-2).	Glucose	103-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	430-435
30636337-1	2019	STUDY OBJECTIVE: Evidence on the cardiotoxicity of nonaspirin nonsteroidal antiinflammatory drugs (NSAIDs), particularly diclofenac and the newer selective cyclooxygenase (COX)-2 inhibitors, has accumulated over the last decade.	nonaspirin	51-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	156-178
30636337-10	2019	Since its introduction in 2003, the use of etoricoxib, a newer selective COX-2 inhibitor, increased in all countries except Denmark, with highest sales in Finland (6.7 DDD/1000 inhabitants/day in 2016).	Etoricoxib	43-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-78
30701538-1	2019	Several clinical studies indicated that the daily use of aspirin or acetylsalicylic acid reduces the cancer risk via cyclooxygenases (Cox-1 and Cox-2) inhibition.	Aspirin	57-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	144-149
30701538-1	2019	Several clinical studies indicated that the daily use of aspirin or acetylsalicylic acid reduces the cancer risk via cyclooxygenases (Cox-1 and Cox-2) inhibition.	Aspirin	68-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	144-149
30585716-1	2019	Two new Co(II) complexes have been synthesized and investigated as catalysts for H2 generation.	Hydrogen	81-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	8-14
30585716-4	2019	Removing just one nitrogen linker between the Co(II)-binding bipyridine groups has a profound impact on the molecular geometry observed by single crystal analysis.	Nitrogen	18-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-52
30585716-4	2019	Removing just one nitrogen linker between the Co(II)-binding bipyridine groups has a profound impact on the molecular geometry observed by single crystal analysis.	2,2'-Dipyridyl	61-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-52
31459350-3	2019	In agreement with previous studies, hydrogen production pathways starting from reduction of the resting state of CoII and involving formation of the CoIIIH and CoIIH intermediates are the favorable ones for both bimetallic and monometallic pathways.	Hydrogen	36-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-117
30618250-0	2019	Solution and Solid State Properties for Low-Spin Cobalt(II) Dibenzotetramethyltetraaza[14]annulene [(tmtaa)CoII] and the Monopyridine Complex.	cobalt(ii) dibenzotetramethyltetraaza[14]annulene	49-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-111
30618250-1	2019	The single-crystal X-ray structure of solvent-free (tmtaa)CoII reveals three different pi-pi intermacrocyclic interactions between tmtaa units (tmtaa = dibenzotetramethyltetraaza[14]annulene).	tmtaa	52-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-62
30618250-1	2019	The single-crystal X-ray structure of solvent-free (tmtaa)CoII reveals three different pi-pi intermacrocyclic interactions between tmtaa units (tmtaa = dibenzotetramethyltetraaza[14]annulene).	tmtaa	131-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-62
30618250-1	2019	The single-crystal X-ray structure of solvent-free (tmtaa)CoII reveals three different pi-pi intermacrocyclic interactions between tmtaa units (tmtaa = dibenzotetramethyltetraaza[14]annulene).	dibenzotetramethyltetraaza	152-178	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-62
30618250-1	2019	The single-crystal X-ray structure of solvent-free (tmtaa)CoII reveals three different pi-pi intermacrocyclic interactions between tmtaa units (tmtaa = dibenzotetramethyltetraaza[14]annulene).	Benzene	182-190	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-62
30618250-6	2019	Toluene solutions of (tmtaa)CoII have 1H nuclear magnetic resonance (NMR) paramagnetic shifts, a solution-phase magnetic moment mueff (295 K) of 2.1 muB, and toluene glass electron paramagnetic resonance spectra that are most consistent with a low-spin ( S = 1/2) CoII with the unpaired electron located in the d yz orbital.	Toluene	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-32
30618250-6	2019	Toluene solutions of (tmtaa)CoII have 1H nuclear magnetic resonance (NMR) paramagnetic shifts, a solution-phase magnetic moment mueff (295 K) of 2.1 muB, and toluene glass electron paramagnetic resonance spectra that are most consistent with a low-spin ( S = 1/2) CoII with the unpaired electron located in the d yz orbital.	Toluene	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	264-268
30618250-6	2019	Toluene solutions of (tmtaa)CoII have 1H nuclear magnetic resonance (NMR) paramagnetic shifts, a solution-phase magnetic moment mueff (295 K) of 2.1 muB, and toluene glass electron paramagnetic resonance spectra that are most consistent with a low-spin ( S = 1/2) CoII with the unpaired electron located in the d yz orbital.	Hydrogen	38-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-32
30618250-6	2019	Toluene solutions of (tmtaa)CoII have 1H nuclear magnetic resonance (NMR) paramagnetic shifts, a solution-phase magnetic moment mueff (295 K) of 2.1 muB, and toluene glass electron paramagnetic resonance spectra that are most consistent with a low-spin ( S = 1/2) CoII with the unpaired electron located in the d yz orbital.	Toluene	158-165	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-32
30618250-7	2019	Pyridine interacts with (tmtaa)CoII to form a five-coordinate monopyridine complex in which the unpaired electron is in the d z2 orbital.	pyridine	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-35
30618250-7	2019	Pyridine interacts with (tmtaa)CoII to form a five-coordinate monopyridine complex in which the unpaired electron is in the d z2 orbital.	tmtaa	25-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-35
30618250-7	2019	Pyridine interacts with (tmtaa)CoII to form a five-coordinate monopyridine complex in which the unpaired electron is in the d z2 orbital.	monopyridine	62-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-35
30620027-1	2019	Two novel sandwich-type polyoxometalates {Na0.7M5.3(H2O)2(imi)2(Himi)(SbW9O33)2}6- (M = NiII (1), CoII (2), imi = imidazole) containing a strong M-Cimi bond were synthesized by a tetragonal cluster [Na2Sb8W36O132(H2O)4]22- {Sb8W36} precursor.	polyoxometalate I	24-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-102
30961684-5	2019	Blocking p38 signaling attenuated the inhibitory effect of 1,25(OH)2D3 on the upregulation of COX-2 and phosphorylation of p38.	Calcitriol	59-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-99
31459350-3	2019	In agreement with previous studies, hydrogen production pathways starting from reduction of the resting state of CoII and involving formation of the CoIIIH and CoIIH intermediates are the favorable ones for both bimetallic and monometallic pathways.	coiiih	149-155	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-117
31459350-3	2019	In agreement with previous studies, hydrogen production pathways starting from reduction of the resting state of CoII and involving formation of the CoIIIH and CoIIH intermediates are the favorable ones for both bimetallic and monometallic pathways.	coiih	160-165	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-117
32254955-9	2019	And, in vivo, multifunctional Pd-Cys@MTX@RGD effectively inhibited the symptoms of RA by inhibiting the expression of pro-inflammatory cytokines (TNF-alpha,COX-2).	pd-cys	30-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	156-161
30556396-0	2019	Temperature-Controlled Degree of Interpenetration in a Single-Crystal-to-Single-Crystal Transformation within Two Co(II)-Triazole Frameworks.	Triazoles	121-129	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-119
30562002-2	2019	The CoII ions are coordinated to these deprotonated ligands in the inner N3O3 site, while the GdIII ion is linked to three deprotonated phenoxo oxygen atoms of two anionic [LCo]- or [L1Co]- units.	n3o3	73-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-8
32254955-9	2019	And, in vivo, multifunctional Pd-Cys@MTX@RGD effectively inhibited the symptoms of RA by inhibiting the expression of pro-inflammatory cytokines (TNF-alpha,COX-2).	Methotrexate	37-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	156-161
31502430-14	2019	The latter enhances COX-2 expression leading to PGE2 release.	Dinoprostone	48-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-25
30391743-5	2019	Casticin significantly inhibited IL-1beta-induced NO and PGE2 production, and iNOS and COX-2 expression in human OA chondrocytes.	casticin	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-92
30545214-1	2019	The first enantioselective Michael addition of 2-acetyl azaarenes to beta-CF3-beta-(3-indolyl)nitroalkenes has been successfully achieved in the presence of a Co(II)/(imidazoline-oxazoline) complex as the catalyst.	2-acetyl azaarenes	47-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	159-165
30545214-1	2019	The first enantioselective Michael addition of 2-acetyl azaarenes to beta-CF3-beta-(3-indolyl)nitroalkenes has been successfully achieved in the presence of a Co(II)/(imidazoline-oxazoline) complex as the catalyst.	beta-cf3-beta-(3-indolyl)nitroalkenes	69-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	159-165
30545214-1	2019	The first enantioselective Michael addition of 2-acetyl azaarenes to beta-CF3-beta-(3-indolyl)nitroalkenes has been successfully achieved in the presence of a Co(II)/(imidazoline-oxazoline) complex as the catalyst.	imidazoline-oxazoline)	167-189	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	159-165
30343113-4	2019	In this study, we proved that TAMs possess the ability to promote OS cell migration and invasion by upregulating COX-2, MMP9, and phosphorylated STAT3 and to induce the epithelial-mesenchymal transition (EMT).	tams	30-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-118
30343113-7	2019	We propose that TAMs promote OS metastasis and invasion by activating the COX-2/STAT3 axis and EMT.	tams	16-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
31459324-0	2019	CoII Complexes with a Tripyridine Ligand, Containing a 2,6-Di-tert-butylphenolic Fragment: Synthesis, Structure, and Formation of Stable Radicals.	2,2',2''-terpyridine	22-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-4
31459324-0	2019	CoII Complexes with a Tripyridine Ligand, Containing a 2,6-Di-tert-butylphenolic Fragment: Synthesis, Structure, and Formation of Stable Radicals.	2,6-di-tert	55-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-4
31459324-5	2019	It was shown by density functional theory calculations that exchange coupling between the unpaired electron of the phenoxyl radical and CoII ions was negligibly weak and could not affect the electron paramagnetic resonance signal of the radical, as well as exchange coupling of CoII ions could not be transmitted by L. The latter conclusion was confirmed by the analysis of magnetic properties of 1: temperature dependency of magnetic susceptibility (chiM) of 1 could be simulated by a simple model for isolated CoII ions.	phenoxy radical	115-131	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	136-140
31562623-1	2019	The Cyclooxygenase enzymes (COX-1 and COX-2) incorporate 2 molecules of O2 into arachidonic acid (AA), resulting in an array of bioactive prostaglandins.	Oxygen	72-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-43
31562623-1	2019	The Cyclooxygenase enzymes (COX-1 and COX-2) incorporate 2 molecules of O2 into arachidonic acid (AA), resulting in an array of bioactive prostaglandins.	Arachidonic Acid	80-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-43
31562623-1	2019	The Cyclooxygenase enzymes (COX-1 and COX-2) incorporate 2 molecules of O2 into arachidonic acid (AA), resulting in an array of bioactive prostaglandins.	Prostaglandins	138-152	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-43
31562623-2	2019	However, much work has been done showing that COX-2 will perform this reaction on several different AA-containing molecules, most importantly, the endocannabinoid 2-arachidonoylglycerol (2-AG).	Endocannabinoids	147-162	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
31562623-2	2019	However, much work has been done showing that COX-2 will perform this reaction on several different AA-containing molecules, most importantly, the endocannabinoid 2-arachidonoylglycerol (2-AG).	glyceryl 2-arachidonate	163-185	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
31562623-2	2019	However, much work has been done showing that COX-2 will perform this reaction on several different AA-containing molecules, most importantly, the endocannabinoid 2-arachidonoylglycerol (2-AG).	glyceryl 2-arachidonate	187-191	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
30378503-14	2019	We also demonstrated that CsA could inhibit the expression of NFATc1 and its downstream genes COX-2, c-Myc, MMP-9, and MMP-2 in OSCC cells.	Cyclosporine	26-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-99
32801406-4	2019	Competitive adsorption tests using multi metals showed that the adsorption affinity of metal ions on the rGO and its NHs follows the order (Cu(II), Zn(II)) > Ni(II) > Co(II) > (Pb(II), Cd(II)), which is similar to the order observed for single-metal adsorption experiments.	Metals	87-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	167-173
31039577-12	2019	Additionally, a combination treatment strategy of low-dose aspirin given concomitantly with a selective COX-2 inhibitor may result in a reduced side effect profile compared to aspirin or selective COX-2 inhibitor use alone.	Aspirin	59-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
31039577-12	2019	Additionally, a combination treatment strategy of low-dose aspirin given concomitantly with a selective COX-2 inhibitor may result in a reduced side effect profile compared to aspirin or selective COX-2 inhibitor use alone.	Aspirin	59-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	197-202
31039577-12	2019	Additionally, a combination treatment strategy of low-dose aspirin given concomitantly with a selective COX-2 inhibitor may result in a reduced side effect profile compared to aspirin or selective COX-2 inhibitor use alone.	Aspirin	176-183	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
30398124-4	2019	OBJECTIVE: Performed a systematic review and meta-analysis to evaluate the potential effect of the cyclo- oxygenases (Cox)-2 inhibitor Celecoxib adjunct treatment in BD through randomized controlled trials (RCT).	Celecoxib	135-144	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-124
30073924-4	2019	Celecoxib, a COX-2 selective inhibitor, has been utilized for over 20 years, particularly as an anti-inflammatory, analgesic and antipyretic medication.	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
30280671-0	2019	3D-QSAR and Molecular Docking Studies on Oxadiazole Substituted Benzimidazole Derivatives: Validation of Experimental Inhibitory Potencies Towards COX-2.	Oxadiazoles	41-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-152
30280671-0	2019	3D-QSAR and Molecular Docking Studies on Oxadiazole Substituted Benzimidazole Derivatives: Validation of Experimental Inhibitory Potencies Towards COX-2.	benzimidazole	64-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-152
30280671-2	2019	Benzimidazole derivatives showed promising anti-inflammatory activity through the inhibition of COX-2 enzyme.	benzimidazole	0-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-101
30280671-3	2019	OBJECTIVE: The structural features necessary for COX-2 inhibitory activity for a series of oxadiazole substituted benzimidazoles were explored through 3D-QSAR, combinatorial library generation (Combi Lab) and molecular docking.	oxadiazole substituted benzimidazoles	91-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-54
30280671-11	2019	CONCLUSION: The present work resulted in the design of more potent benzimidazoles as COX-2 inhibitors with good interaction as compared to reference ligand.	Benzimidazoles	67-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-90
31210111-0	2019	Application of a Validated QSTR Model for Repurposing COX-2 Inhibitor Coumarin Derivatives as Potential Antitumor Agents.	coumarin	70-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-59
30760195-0	2019	The Neuromodulatory Effects of omega-3 Fatty Acids and Nano-Curcumin on the COX-2/ iNOS Network in Migraines: A Clinical Trial Study from Gene Expression to Clinical Symptoms.	Fatty Acids, Omega-3	31-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-81
30760195-0	2019	The Neuromodulatory Effects of omega-3 Fatty Acids and Nano-Curcumin on the COX-2/ iNOS Network in Migraines: A Clinical Trial Study from Gene Expression to Clinical Symptoms.	nano-curcumin	55-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-81
30760195-4	2019	Omega- 3 fatty acids and curcumin, an active polyphenol of turmeric, have anti-inflammatory and neuroprotective effects through several mechanisms, including the suppression of COX-2 and iNOS gene expression, as well as their serum levels.	Fatty Acids, Omega-3	0-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	177-182
30760195-4	2019	Omega- 3 fatty acids and curcumin, an active polyphenol of turmeric, have anti-inflammatory and neuroprotective effects through several mechanisms, including the suppression of COX-2 and iNOS gene expression, as well as their serum levels.	Curcumin	25-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	177-182
30760195-9	2019	RESULTS: The results of the present trial showed that omega-3 fatty acids and nano-curcumin can reinforce each other"s effects in the downregulation of COX-2/iNOS mRNA, as well as reduce their serum levels.	Fatty Acids, Omega-3	54-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-157
30760195-9	2019	RESULTS: The results of the present trial showed that omega-3 fatty acids and nano-curcumin can reinforce each other"s effects in the downregulation of COX-2/iNOS mRNA, as well as reduce their serum levels.	nano	78-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-157
30760195-9	2019	RESULTS: The results of the present trial showed that omega-3 fatty acids and nano-curcumin can reinforce each other"s effects in the downregulation of COX-2/iNOS mRNA, as well as reduce their serum levels.	Curcumin	83-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-157
30096040-0	2019	Residual cyclooxygenase activity of aspirin-acetylated COX-2 forms 15 R-prostaglandins that inhibit platelet aggregation.	Aspirin	36-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-60
30096040-0	2019	Residual cyclooxygenase activity of aspirin-acetylated COX-2 forms 15 R-prostaglandins that inhibit platelet aggregation.	r-prostaglandins	70-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-60
30096040-3	2019	Acetylated COX-2, in contrast, gains a new catalytic activity and forms 15 R hydroxy-eicosatetraenoic acid (15 R-HETE) as alternate product.	15 r hydroxy-eicosatetraenoic acid	72-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-16
30096040-3	2019	Acetylated COX-2, in contrast, gains a new catalytic activity and forms 15 R hydroxy-eicosatetraenoic acid (15 R-HETE) as alternate product.	15 r-hete	108-117	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-16
30096040-4	2019	Here we show that acetylated COX-2 also retains COX activity, forming predominantly 15 R-configuration PGs (70 or 62% 15 R, respectively, determined using radiolabeled substrate or LC-MS analysis).	Phosphatidylglycerols	103-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34
30096040-5	2019	Although the Km of arachidonic acid for acetylated COX-2 was ~3-fold lower than for uninhibited COX-2, the catalytic efficiency for PG formation by the acetylated enzyme was reduced 10-fold due to a concomitant decrease in Vmax.	Arachidonic Acid	19-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-56
30096040-5	2019	Although the Km of arachidonic acid for acetylated COX-2 was ~3-fold lower than for uninhibited COX-2, the catalytic efficiency for PG formation by the acetylated enzyme was reduced 10-fold due to a concomitant decrease in Vmax.	Arachidonic Acid	19-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-101
30096040-6	2019	Aspirin increased 15 R-PGD2 but not 15 R-PGE2 in isolated human leukocytes activated with LPS to induce COX-2.	Aspirin	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
30096040-8	2019	We conclude that acetylation of Ser530 in COX-2 not only triggers formation of 15 R-HETE but also allows oxygenation and cyclization of arachidonic acid to a 15 R-PG endoperoxide.	Hydroxyeicosatetraenoic Acids	83-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47
30096040-8	2019	We conclude that acetylation of Ser530 in COX-2 not only triggers formation of 15 R-HETE but also allows oxygenation and cyclization of arachidonic acid to a 15 R-PG endoperoxide.	Arachidonic Acid	136-152	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47
30096040-9	2019	15 R-PGs are novel products of aspirin therapy via acetylation of COX-2 and may contribute to its antiplatelet and other pharmacologic effects.-Gimenez-Bastida, J.	Aspirin	31-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-71
30096040-10	2019	A., Boeglin, W. E., Boutaud, O., Malkowski, M. G., Schneider, C. Residual cyclooxygenase activity of aspirin-acetylated COX-2 forms 15 R-prostaglandins that inhibit platelet aggregation.	Aspirin	101-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-125
30096040-10	2019	A., Boeglin, W. E., Boutaud, O., Malkowski, M. G., Schneider, C. Residual cyclooxygenase activity of aspirin-acetylated COX-2 forms 15 R-prostaglandins that inhibit platelet aggregation.	r-prostaglandins	135-151	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-125
31903891-2	2019	Cox17 shuttles copper ions from the cytosol to the mitochondria and, together with Sco1 and Sco2, provides copper ions to the Cox1 and Cox2 mitochondrially encoded subunits.	Copper	15-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-139
31903891-2	2019	Cox17 shuttles copper ions from the cytosol to the mitochondria and, together with Sco1 and Sco2, provides copper ions to the Cox1 and Cox2 mitochondrially encoded subunits.	Copper	107-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-139
30287340-8	2019	The role of cyclooxygenase-2 (COX-2 [encoded by PTGS2]) on ketoconazole-induced mitophagy was evaluated using gain- and loss-of-function methods.	Ketoconazole	59-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-35
30287340-11	2019	Mechanistically, ketoconazole downregulated COX-2, which led to PINK1 accumulation and subsequent mitochondrial translocation of Parkin (PRKN), and thereby promoted mitophagy-mediated mitochondrial dysfunction.	Ketoconazole	17-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-49
30287340-13	2019	In the HCC PDX model, ketoconazole demonstrated a marked antitumor effect characterized by COX-2 downregulation, mitophagy activation, and apoptosis induction.	Ketoconazole	22-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-96
30287340-17	2019	Our study reveals that ketoconazole, a broad-spectrum antifungal agent, activates PINK1/Parkin-mediated mitophagy by downregulating COX-2, consequently resulting in the acceleration of apoptosis and thereby inhibiting the growth of HCC.	Ketoconazole	23-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-137
30168128-2	2019	Among the various eicosanoid metabolic pathways, studies of their role in endometrial cancer (EC) have very much been confined to the COX-2 pathway.	Eicosanoids	18-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-139
30168128-6	2019	Integration of eicosanoid and gene expression data showed that the accepted paradigm of increased COX-2-mediated prostaglandin production does not apply in EC carcinogenesis.	Prostaglandins	113-126	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-103
30608392-1	2019	BACKGROUND: Parecoxib is a selective cyclooxygenase (COX)-2 inhibitor widely used as an analgesia technique in perioperative period for its potent anti-inflammatory and analgesic effects.	parecoxib	12-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-59
30836912-0	2019	Synthesis, Structural Characterization, Molecular Modeling and DNA Binding Ability of CoII, NiII, CuII, ZnII, PdII and CdII Complexes of Benzocycloheptenone Thiosemicarbazone Ligand.	benzocycloheptenone thiosemicarbazone	137-174	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-90
30633587-7	2019	Western blotting results showed the expression of NF-kappaB signaling pathway factors, p-ERK, TRAF2, and p-IkappaBalpha, increased following treatment with oligonol, whereas p65 and COX-2 expression decreased.	oligonol	156-164	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	182-187
31502430-8	2019	FTY720-P increased the expression of COX2, and reduced that of IkappaB.	FTY 720P	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-41
30990358-1	2019	In this work, we have synthesized a few novel mononuclear complexes of Cu(II), Co(II), Ni(II) and Zn(II) using a pyrazolone-derived Schiff base ligand.	pyrazolone	113-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-85
30990358-1	2019	In this work, we have synthesized a few novel mononuclear complexes of Cu(II), Co(II), Ni(II) and Zn(II) using a pyrazolone-derived Schiff base ligand.	Schiff Bases	132-143	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-85
30384258-1	2019	We recently reported that siRNA-knockdown of delta-5-desaturase (D5D), the rate-limiting enzyme converting upstream omega - 6 dihomo-gamma-linolenic acid (DGLA) to arachidonic acid, promoted formation of the anti-cancer byproduct 8-hydroxyoctanoic acid (8-HOA) from COX-2-catalyzed DGLA peroxidation, consequently suppressing pancreatic cancer cell growth, migration and invasion.	omega - 6 dihomo-gamma-linolenic acid	116-153	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	266-271
30599890-10	2019	Further investigation of the mechanism of action of curcumin and quercetin in melanoma cells, A375, suggested that inhibition of cell proliferation occurred through down-regulation of Wnt/beta-catenin signaling pathway proteins, DVL2, beta-catenin, cyclin D1, Cox2, and Axin2.	Curcumin	52-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	260-264
30384258-1	2019	We recently reported that siRNA-knockdown of delta-5-desaturase (D5D), the rate-limiting enzyme converting upstream omega - 6 dihomo-gamma-linolenic acid (DGLA) to arachidonic acid, promoted formation of the anti-cancer byproduct 8-hydroxyoctanoic acid (8-HOA) from COX-2-catalyzed DGLA peroxidation, consequently suppressing pancreatic cancer cell growth, migration and invasion.	8,11,14-Eicosatrienoic Acid	155-159	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	266-271
30384258-1	2019	We recently reported that siRNA-knockdown of delta-5-desaturase (D5D), the rate-limiting enzyme converting upstream omega - 6 dihomo-gamma-linolenic acid (DGLA) to arachidonic acid, promoted formation of the anti-cancer byproduct 8-hydroxyoctanoic acid (8-HOA) from COX-2-catalyzed DGLA peroxidation, consequently suppressing pancreatic cancer cell growth, migration and invasion.	Arachidonic Acid	164-180	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	266-271
30384258-1	2019	We recently reported that siRNA-knockdown of delta-5-desaturase (D5D), the rate-limiting enzyme converting upstream omega - 6 dihomo-gamma-linolenic acid (DGLA) to arachidonic acid, promoted formation of the anti-cancer byproduct 8-hydroxyoctanoic acid (8-HOA) from COX-2-catalyzed DGLA peroxidation, consequently suppressing pancreatic cancer cell growth, migration and invasion.	8-hydroxyoctanoic acid	230-252	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	266-271
30384258-1	2019	We recently reported that siRNA-knockdown of delta-5-desaturase (D5D), the rate-limiting enzyme converting upstream omega - 6 dihomo-gamma-linolenic acid (DGLA) to arachidonic acid, promoted formation of the anti-cancer byproduct 8-hydroxyoctanoic acid (8-HOA) from COX-2-catalyzed DGLA peroxidation, consequently suppressing pancreatic cancer cell growth, migration and invasion.	8-hydroxyoctanoic acid	254-259	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	266-271
30384258-1	2019	We recently reported that siRNA-knockdown of delta-5-desaturase (D5D), the rate-limiting enzyme converting upstream omega - 6 dihomo-gamma-linolenic acid (DGLA) to arachidonic acid, promoted formation of the anti-cancer byproduct 8-hydroxyoctanoic acid (8-HOA) from COX-2-catalyzed DGLA peroxidation, consequently suppressing pancreatic cancer cell growth, migration and invasion.	8,11,14-Eicosatrienoic Acid	282-286	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	266-271
30384258-2	2019	In this study, we have further investigated the anti-tumor effects of D5D-knockdown and the resulting intensified COX-2-catalyzed DGLA peroxidation in subcutaneous xenograft tumors.	8,11,14-Eicosatrienoic Acid	130-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-119
30579354-8	2018	Moreover, simvastatin suppressed the expression of COX-2 and PGE2 in both OE-19 and Eca-109 cells in a dose-dependent manner.	Simvastatin	10-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-56
31032775-6	2019	RESULTS: Compared with the control group, IL-6, TNF-alpha and Cox-2 significantly increased in BeWo cells which were exposed in 50 nmol/L DON in 3, 12 and 24 h(P&lt;0.	DONS	138-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
30596805-0	2018	Retraction: Green Tea Catechins Reduce Invasive Potential of Human Melanoma Cells by Targeting COX-2, PGE2 Receptors and Epithelial-to-Mesenchymal Transition.	Catechin	22-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-100
30579354-10	2018	The reduction of COX-2 and PGE2 by simvastatin suggested that the inhibitory effect of simvastatin on the proliferation of EC cells may be independent of its lipid-lowering effect.	Simvastatin	35-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22
30579354-10	2018	The reduction of COX-2 and PGE2 by simvastatin suggested that the inhibitory effect of simvastatin on the proliferation of EC cells may be independent of its lipid-lowering effect.	Simvastatin	87-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22
30512937-3	2018	Here, we provide evidence for multiple NOR turnover in monoformyl-heme-containing FeBMb1 proteins loaded with FeII, CoII, or ZnII metal ions at the FeB site (FeII/CoII/ZnII-FeBMb1(MF-heme)).	monoformyl-heme	55-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-120
30622945-10	2018	Moreover, PL induced an early and transient increase of the pro-inflammatory response triggered by IL-1alpha, by inducing COX-2 expression and secretion of a large amount of PGE2, IL-6, and IL-8.	pl	10-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-127
30619324-9	2018	The small molecule inhibitor Sc514 also demonstrated ability to inhibit COX2 protein responses and a broad down-regulatory effect on uterine cell inflammatory gene expression.	SC 514	29-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-76
30462116-1	2018	We report the synthesis, structural characterization and a combined computational and experimental study of the magnetic properties of two pivalate cobalt complexes, a mononuclear Co(ii) one and a tetranuclear Co(ii)3Co(iii) mixed valence polynuclear one.	Cobalt	148-154	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	183-185
30512937-3	2018	Here, we provide evidence for multiple NOR turnover in monoformyl-heme-containing FeBMb1 proteins loaded with FeII, CoII, or ZnII metal ions at the FeB site (FeII/CoII/ZnII-FeBMb1(MF-heme)).	monoformyl-heme	55-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	163-167
30512937-3	2018	Here, we provide evidence for multiple NOR turnover in monoformyl-heme-containing FeBMb1 proteins loaded with FeII, CoII, or ZnII metal ions at the FeB site (FeII/CoII/ZnII-FeBMb1(MF-heme)).	Metals	130-135	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	163-167
31458347-7	2018	The order of the selectivity of cross-linked chitosan derivatives toward metal ions was found to be Cu(II) &gt; Cd(II) &gt; Fe(II) &gt; Co(II) &gt; Ni(II).	Metals	73-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	136-142
30520483-0	2018	Magnetic, thermal, and neutron diffraction studies of a coordination polymer: bis(glycolato)cobalt(ii).	Polymers	69-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-101
30520483-1	2018	The two-dimensional quadratic lattice magnet, bis(glycolato)cobalt(ii) ([Co(HOCH2CO2)2]), showed antiferromagnetic ordering at 15.0 K and an abrupt increase in magnetisation at H = 22 600 Oe and 2 K, thereby acting as a metamagnet.	co(hoch2co2)2	73-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-69
31458347-7	2018	The order of the selectivity of cross-linked chitosan derivatives toward metal ions was found to be Cu(II) &gt; Cd(II) &gt; Fe(II) &gt; Co(II) &gt; Ni(II).	cu(ii)	100-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	136-142
31458347-7	2018	The order of the selectivity of cross-linked chitosan derivatives toward metal ions was found to be Cu(II) &gt; Cd(II) &gt; Fe(II) &gt; Co(II) &gt; Ni(II).	ammonium ferrous sulfate	124-130	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	136-142
30511846-0	2018	Metamagnetism in Nanosheets of CoII-MOF with TN at 26 K and a Giant Hysteretic Effect at 5 K. Herein, we have synthesized at room-temperature two-dimensional nanosheets of a MOF comprised of cobalt(II) ion with benzenedicarboxylic acid  ligand, which exhibited unusual magnetic properties.	Cobalt(2+)	191-201	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-35
31458347-7	2018	The order of the selectivity of cross-linked chitosan derivatives toward metal ions was found to be Cu(II) &gt; Cd(II) &gt; Fe(II) &gt; Co(II) &gt; Ni(II).	Nickel(2+)	148-154	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	136-142
30511846-0	2018	Metamagnetism in Nanosheets of CoII-MOF with TN at 26 K and a Giant Hysteretic Effect at 5 K. Herein, we have synthesized at room-temperature two-dimensional nanosheets of a MOF comprised of cobalt(II) ion with benzenedicarboxylic acid  ligand, which exhibited unusual magnetic properties.	benzenedicarboxylic acid	211-235	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-35
30619920-1	2019	The data presented in this article is related to the research article entitled "Electrochemical and electronic properties of a series of substituted polypyridine ligands and their Co(II) complexes" (Ferreira et al., 2019).	PYRIDINE	149-161	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	180-186
30619920-2	2019	This data article presents electrochemical data of five polypyridine ligands, as well as of the three redox couples of each of their corresponding five polypyridine-containing Co(II) complexes.	PYRIDINE	152-164	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	176-182
30881630-2	2019	Here we have developed conditions for preparing a broad range of architectures that are both soluble and kinetically stable in water through metal(ii)-templated (MII = CoII, NiII, ZnII, CdII) subcomponent self-assembly.	metal(ii)	141-150	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	168-172
30662670-6	2018	Of note, PI3K/Akt/Cox2 axis is activated in the co-culturing system and LY294002 abrogates the co-culturing system"s effects on cell proliferation, apoptosis and cytokines secretion, which are reversed by synergistically overexpressing Cox2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	72-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	236-240
30558277-4	2018	In this study we analyzed the relative activity of human recombinant enzymes COX-2, 5-LOX, and 15-LOX-2 using a library of arachidonic acids variably deuterated at the bis-allylic (C7, C10, and C13) positions.	Arachidonic Acids	123-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-82
30881630-6	2019	Architectures that disassembled when CoII, ZnII and CdII templates were employed could be directly prepared from NiSO4 in water.	nickel sulfate	113-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-41
30881630-6	2019	Architectures that disassembled when CoII, ZnII and CdII templates were employed could be directly prepared from NiSO4 in water.	Water	122-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-41
30055453-1	2018	In this study, two novel binuclear Co(II) complexes, [Co4(L1)2(CH3CH2O)4 5.5H2O (1) and [Co2(L2)2(CH3COO)(H2O)] 2CH3OH 3H2O (2)], with the ligands H3L1 and H2L2 were synthesized and structurally characterized using single crystal X-ray diffraction.	co2(l2)2(ch3coo)(h2o)] 2ch3oh 3h2o	89-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-41
30055453-1	2018	In this study, two novel binuclear Co(II) complexes, [Co4(L1)2(CH3CH2O)4 5.5H2O (1) and [Co2(L2)2(CH3COO)(H2O)] 2CH3OH 3H2O (2)], with the ligands H3L1 and H2L2 were synthesized and structurally characterized using single crystal X-ray diffraction.	[co4(l1)2(ch3ch2o)4 5.5h2o	53-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-41
30362217-4	2018	The increased photocatalytic performance of CoZn is due to the enhanced dinuclear metal synergistic catalysis (DMSC) effect between ZnII and CoII , which dramatically lowers the activation barriers of both transition states of CO2 reduction.	cozn	44-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	141-145
30362217-4	2018	The increased photocatalytic performance of CoZn is due to the enhanced dinuclear metal synergistic catalysis (DMSC) effect between ZnII and CoII , which dramatically lowers the activation barriers of both transition states of CO2 reduction.	Metals	82-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	141-145
30362217-4	2018	The increased photocatalytic performance of CoZn is due to the enhanced dinuclear metal synergistic catalysis (DMSC) effect between ZnII and CoII , which dramatically lowers the activation barriers of both transition states of CO2 reduction.	doxycycline fosfatex	111-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	141-145
30362217-4	2018	The increased photocatalytic performance of CoZn is due to the enhanced dinuclear metal synergistic catalysis (DMSC) effect between ZnII and CoII , which dramatically lowers the activation barriers of both transition states of CO2 reduction.	N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)-4-((4-fluorobenzyl)oxy)pyridine-2,6-dicarboxamide	227-230	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	141-145
30368201-6	2018	Downregulation of Cox-2 and survivin and cell cycle arrest eventually leading to apoptosis were found to be the underlying mechanism of the anti-cancer effect of these unnatural meroterpenoids.	meroterpenoids	178-192	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-23
30315753-3	2018	NSAIDs exert their anti-inflammatory, analgesic and anti-pyretic actions by inhibiting the cyclooxygenases (COX)-1 and COX-2, key enzymes of the arachidonic acid (AA) cascade.	Arachidonic Acid	145-161	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-124
29777525-3	2018	After their complexation with hydroxy naphthol blue (HNB) in the presence of cationic surfactant, CTAB at pH 4.0, the Ni(II) and Co(II) were taken within the micellar phase of nonionic surfactant, TX-114.	trisodium 3-hydroxy-4-((2Z)-2-(2-oxo-4-sulfonatonaphthalen-1-ylidene)hydrazinyl)naphthalene-2,7-disulfonate	30-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-135
29777525-3	2018	After their complexation with hydroxy naphthol blue (HNB) in the presence of cationic surfactant, CTAB at pH 4.0, the Ni(II) and Co(II) were taken within the micellar phase of nonionic surfactant, TX-114.	trisodium 3-hydroxy-4-((2Z)-2-(2-oxo-4-sulfonatonaphthalen-1-ylidene)hydrazinyl)naphthalene-2,7-disulfonate	53-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-135
29777525-6	2018	The analytical features obtained after optimization are as follows: limits of detection are 0.56 and 0.78 mug/L; sensitivity enhancement factors are 48.6 and 53.9; the calibration curves were linear 3-180 and 2-160 mug/L for Co(II) and Ni(II), respectively, after preconcentration of 50-fold.	Nickel(2+)	236-242	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	225-231
30627586-6	2018	Results: In this study, PF treatment significantly inhibited NF-kappaB activation and downregulated the expression of inducible nitric oxide synthase (iNOS), cyclooxygenase-2(COX-2), and Nogo-A.	peoniflorin	24-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	175-180
30389270-8	2018	It appears to induce the COX2/PGE2 (Cyclooxygenase2/Prostaglandin E2) pathway described earlier as a major mechanism of MSC-directed immune-suppression.	Dinoprostone	30-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-29
30195234-6	2018	This result was confirmed by molecular docking, which showed that these four natural lead-compounds adopt the same orientation as Rofecoxib in the COX-2 active site.	rofecoxib	130-139	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-152
30081353-0	2018	1,2,3-triazole tethered Indole-3-glyoxamide derivatives as multiple inhibitors of 5-LOX, COX-2 &amp; tubulin: Their anti-proliferative &amp; anti-inflammatory activity.	Triazoles	0-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-94
30081353-0	2018	1,2,3-triazole tethered Indole-3-glyoxamide derivatives as multiple inhibitors of 5-LOX, COX-2 &amp; tubulin: Their anti-proliferative &amp; anti-inflammatory activity.	indole-3-glyoxamide	24-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-94
30081353-0	2018	1,2,3-triazole tethered Indole-3-glyoxamide derivatives as multiple inhibitors of 5-LOX, COX-2 &amp; tubulin: Their anti-proliferative &amp; anti-inflammatory activity.	Adenosine Monophosphate	136-139	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-94
30372880-7	2018	The administration of AJE also inhibits DSS-induced pro-inflammatory cytokines expression, including interleukin (IL)-1beta, IL-6, tumor necrosis factor (TNF)-alpha, and cyclooxygenase (COX)-2.	dss	40-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	170-192
30372880-10	2018	Furthermore, in vitro studies demonstrated that AJE inhibits TNF-alpha-induced IL-8, IL-1beta, and COX-2 expression in human intestinal epithelial HT-29 cells and tert-butyl hydroperoxide-induced reduction of ZO-1 and occludin expression in human intestinal epithelial Caco-2 cells.	aje	48-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-104
30276925-2	2018	Several metal ions (CuII , NiII , MgII , MnII , CoII , and ZnII ) were selected as the central metal ion, and chiral drugs ezetimibe (EZM) and ambrisentan (AMB) were used as the reference to each other for isomeric differentiation by using electrospray ionization quadrupole time-of-flight mass spectrometry.	Metals	8-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-52
30542493-8	2018	Concurrently, avicularin inhibited the mRNA and protein expression levels of iNOS and COX-2 increased by TNF-alpha.	avicularin	14-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-91
30312760-0	2018	Up-regulation of COX-2 and mPGES-1 by 27-hydroxycholesterol and 4-hydroxynonenal: A crucial role in atherosclerotic plaque instability.	27-hydroxycholesterol	38-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22
30312760-0	2018	Up-regulation of COX-2 and mPGES-1 by 27-hydroxycholesterol and 4-hydroxynonenal: A crucial role in atherosclerotic plaque instability.	4-hydroxy-2-nonenal	64-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22
30312760-5	2018	This study shows that 27-OH and HNE promote up-regulation of both the inducible enzymes COX-2 and mPGES-1, leading to increased production of prostaglandin (PG) E2 and inducible nitric oxide synthase, and the subsequent release of nitric oxide in human promonocytic U937 cells.	Dinoprostone	142-163	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-93
30312760-5	2018	This study shows that 27-OH and HNE promote up-regulation of both the inducible enzymes COX-2 and mPGES-1, leading to increased production of prostaglandin (PG) E2 and inducible nitric oxide synthase, and the subsequent release of nitric oxide in human promonocytic U937 cells.	Nitric Oxide	178-190	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-93
30312760-7	2018	This enhancement is presumably due to the induction of PGE2 synthesis, as a result of the up-regulation of the COX-2/mPGES-1, stimulated by the two oxidized lipids, 27-OH and HNE.	Dinoprostone	55-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	111-116
29199524-5	2018	Fluorescence titration studies reveal that these compounds bind strongly with CT-DNA through intercalative mode (Kapp 105 M-1) and follow the order: Cu(II) &gt; Zn(II) &gt; Ni(II) &gt; Co(II) &gt; L. Molecular docking study substantiate the strength and mode of binding of these compounds with DNA.	cu(ii)	149-155	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	185-191
30291943-6	2018	FVA extract (50 mug/mL) significantly inhibited cyclooxygenase-1 and -2 (COX-1 and COX-2) activities in vitro (&gt;50% inhibition), and FVR extract considerably inhibited COX-2 activity (52.5 +- 2.7%) without affecting COX-2 gene expression in LPS-stimulated THP-1 cells.	fva	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
30291943-6	2018	FVA extract (50 mug/mL) significantly inhibited cyclooxygenase-1 and -2 (COX-1 and COX-2) activities in vitro (&gt;50% inhibition), and FVR extract considerably inhibited COX-2 activity (52.5 +- 2.7%) without affecting COX-2 gene expression in LPS-stimulated THP-1 cells.	fva	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	171-176
30291943-6	2018	FVA extract (50 mug/mL) significantly inhibited cyclooxygenase-1 and -2 (COX-1 and COX-2) activities in vitro (&gt;50% inhibition), and FVR extract considerably inhibited COX-2 activity (52.5 +- 2.7%) without affecting COX-2 gene expression in LPS-stimulated THP-1 cells.	fva	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	171-176
29806488-0	2018	Synthesis, antitumour activities and molecular docking of thiocarboxylic acid ester-based NSAID scaffolds: COX-2 inhibition and mechanistic studies.	thiocarboxylic acid ester	58-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-112
30276925-2	2018	Several metal ions (CuII , NiII , MgII , MnII , CoII , and ZnII ) were selected as the central metal ion, and chiral drugs ezetimibe (EZM) and ambrisentan (AMB) were used as the reference to each other for isomeric differentiation by using electrospray ionization quadrupole time-of-flight mass spectrometry.	Metals	95-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-52
30270026-5	2018	RESULTS: COX-2 was neo-expressed in 86.6% of the cases and expression progressively increased from ePP to ePSCC (P = 0.0003) and from well to poorly differentiated (P = 0.033).	neo	19-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	9-14
30403243-9	2018	Mechanistic studies by western blot analysis demonstrate that benzylic selenocyanates exhibit anti-proliferative activities by modulating key cellular proteins such as Survivin, Bcl-2 and COX-2; this was further supported by molecular docking studies.	selenocyanic acid	71-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	188-193
30398331-0	2018	Oxygen-Oxygen Bond Cleavage and Formation in Co(II)-Mediated Stoichiometric O2 Reduction via the Potential Intermediacy of a Co(IV) Oxyl Radical.	Oxygen	0-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-51
30398331-0	2018	Oxygen-Oxygen Bond Cleavage and Formation in Co(II)-Mediated Stoichiometric O2 Reduction via the Potential Intermediacy of a Co(IV) Oxyl Radical.	Oxygen	7-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-51
30398331-0	2018	Oxygen-Oxygen Bond Cleavage and Formation in Co(II)-Mediated Stoichiometric O2 Reduction via the Potential Intermediacy of a Co(IV) Oxyl Radical.	Oxygen	76-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-51
30398331-0	2018	Oxygen-Oxygen Bond Cleavage and Formation in Co(II)-Mediated Stoichiometric O2 Reduction via the Potential Intermediacy of a Co(IV) Oxyl Radical.	co(iv) oxyl radical	125-144	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-51
30398331-7	2018	Thus, the study demonstrates both facile O-O bond cleavage and formation in the stoichiometric reduction of O2 to H2O with 2 equiv of Co(II) and suggests a new pathway for selective reduction of O2 to water via Co(III)-O-O-Co(III) peroxo intermediates.	Oxygen	41-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-140
30398331-7	2018	Thus, the study demonstrates both facile O-O bond cleavage and formation in the stoichiometric reduction of O2 to H2O with 2 equiv of Co(II) and suggests a new pathway for selective reduction of O2 to water via Co(III)-O-O-Co(III) peroxo intermediates.	Oxygen	108-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-140
30398331-7	2018	Thus, the study demonstrates both facile O-O bond cleavage and formation in the stoichiometric reduction of O2 to H2O with 2 equiv of Co(II) and suggests a new pathway for selective reduction of O2 to water via Co(III)-O-O-Co(III) peroxo intermediates.	Water	114-117	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-140
30398331-7	2018	Thus, the study demonstrates both facile O-O bond cleavage and formation in the stoichiometric reduction of O2 to H2O with 2 equiv of Co(II) and suggests a new pathway for selective reduction of O2 to water via Co(III)-O-O-Co(III) peroxo intermediates.	Oxygen	195-197	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-140
30398331-7	2018	Thus, the study demonstrates both facile O-O bond cleavage and formation in the stoichiometric reduction of O2 to H2O with 2 equiv of Co(II) and suggests a new pathway for selective reduction of O2 to water via Co(III)-O-O-Co(III) peroxo intermediates.	Water	201-206	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-140
30398331-7	2018	Thus, the study demonstrates both facile O-O bond cleavage and formation in the stoichiometric reduction of O2 to H2O with 2 equiv of Co(II) and suggests a new pathway for selective reduction of O2 to water via Co(III)-O-O-Co(III) peroxo intermediates.	peroxo	231-237	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-140
30469399-0	2018	Metformin Inhibits Migration and Invasion by Suppressing ROS Production and COX2 Expression in MDA-MB-231 Breast Cancer Cells.	Metformin	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-80
30469399-8	2018	At 100 microM, however, metformin reduced ICAM1 and COX2 expression, as well as reduced PGE2 production and endogenous mitochondrial ROS production while failing to significantly impact cell viability.	Metformin	24-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-56
30177164-2	2018	Obtained Co(II)-RLMP complexes, with cobalt content ~2-8% (AAS), were characterized by UV-Vis spectrophotometry, FTIR spectroscopy (ATR-FTIR, FT-IRIS), MALDI-TOF/TOF MS, and XRD.	Cobalt	37-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	9-15
31458193-0	2018	Multifunctional Properties of a 1D Helical Co(II) Coordination Polymer: Toward Single-Ion Magnetic Behavior and Efficient Dye Degradation.	Polymers	63-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-49
30498475-9	2018	ChIP-qPCR assays indicated that ATF4 could directly bind to the COX2 promoter and that ATF4 knockdown could attenuate human chorionic gonadotropin (hCG)-induced COX2 expression and PGE2 production.	Dinoprostone	181-185	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-68
30378605-0	2018	The structurally variable network of spin couplings and migrating paramagnetic centers in binuclear o-quinone CoII complexes with biradical acene linkers: a computational DFT study.	2-benzoquinone	100-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-114
30378605-0	2018	The structurally variable network of spin couplings and migrating paramagnetic centers in binuclear o-quinone CoII complexes with biradical acene linkers: a computational DFT study.	anthracene	140-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-114
30378605-4	2018	The considered binuclear CoII diketonate adducts manifest the capability of undergoing one- and two-step spin transitions induced by intramolecular electron transfers between the metal ions and the ligand system.	Metals	179-184	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-29
31458193-2	2018	The reaction with the Co(II) salt in the presence of a co-ligand 2,9-dimethyl phenanthroline (dmphen) results in the formation of the helical compound {[Co2(dmphen)2(CPCA)2]DMF} n (1).	neocuproine	65-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-28
31458193-2	2018	The reaction with the Co(II) salt in the presence of a co-ligand 2,9-dimethyl phenanthroline (dmphen) results in the formation of the helical compound {[Co2(dmphen)2(CPCA)2]DMF} n (1).	neocuproine	94-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-28
31458193-2	2018	The reaction with the Co(II) salt in the presence of a co-ligand 2,9-dimethyl phenanthroline (dmphen) results in the formation of the helical compound {[Co2(dmphen)2(CPCA)2]DMF} n (1).	co2(dmphen)2(cpca)2]dmf	153-176	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-28
31458193-3	2018	However, two isostructural monomeric complexes are formed {[M(HCPCA)2(H2O)2], M = Co(II), (2) and Mn(II) (3)} when reactions were carried out in the absence of dmphen.	hcpca)2	62-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-88
31458193-3	2018	However, two isostructural monomeric complexes are formed {[M(HCPCA)2(H2O)2], M = Co(II), (2) and Mn(II) (3)} when reactions were carried out in the absence of dmphen.	Water	70-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-88
30314699-0	2018	lncRNA HOTAIR upregulates COX-2 expression to promote invasion and migration of nasopharyngeal carcinoma by interacting with miR-101.	mir-101	125-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-31
30129103-2	2018	Gas sorption results for these highly mesoporous materials show that alternately arranged fused benzene rings on one side of the ligand could serve as extra anchoring sites for CO2 molecules with pi-pi interactions, conspicuously enhancing CO2 uptake and CO2 /CH4 and CO2 /N2 selectivity; while more steric hindrance effect towards open CoII sites were imposed by ligands flanked with fused benzene rings on both sides, compromising such extra-sites enhancement.	Benzene	96-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	337-341
30129103-2	2018	Gas sorption results for these highly mesoporous materials show that alternately arranged fused benzene rings on one side of the ligand could serve as extra anchoring sites for CO2 molecules with pi-pi interactions, conspicuously enhancing CO2 uptake and CO2 /CH4 and CO2 /N2 selectivity; while more steric hindrance effect towards open CoII sites were imposed by ligands flanked with fused benzene rings on both sides, compromising such extra-sites enhancement.	Carbon Dioxide	177-180	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	337-341
30129103-2	2018	Gas sorption results for these highly mesoporous materials show that alternately arranged fused benzene rings on one side of the ligand could serve as extra anchoring sites for CO2 molecules with pi-pi interactions, conspicuously enhancing CO2 uptake and CO2 /CH4 and CO2 /N2 selectivity; while more steric hindrance effect towards open CoII sites were imposed by ligands flanked with fused benzene rings on both sides, compromising such extra-sites enhancement.	Carbon Dioxide	240-243	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	337-341
30129103-2	2018	Gas sorption results for these highly mesoporous materials show that alternately arranged fused benzene rings on one side of the ligand could serve as extra anchoring sites for CO2 molecules with pi-pi interactions, conspicuously enhancing CO2 uptake and CO2 /CH4 and CO2 /N2 selectivity; while more steric hindrance effect towards open CoII sites were imposed by ligands flanked with fused benzene rings on both sides, compromising such extra-sites enhancement.	Carbon Dioxide	240-243	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	337-341
30129103-2	2018	Gas sorption results for these highly mesoporous materials show that alternately arranged fused benzene rings on one side of the ligand could serve as extra anchoring sites for CO2 molecules with pi-pi interactions, conspicuously enhancing CO2 uptake and CO2 /CH4 and CO2 /N2 selectivity; while more steric hindrance effect towards open CoII sites were imposed by ligands flanked with fused benzene rings on both sides, compromising such extra-sites enhancement.	Methane	260-263	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	337-341
30129103-2	2018	Gas sorption results for these highly mesoporous materials show that alternately arranged fused benzene rings on one side of the ligand could serve as extra anchoring sites for CO2 molecules with pi-pi interactions, conspicuously enhancing CO2 uptake and CO2 /CH4 and CO2 /N2 selectivity; while more steric hindrance effect towards open CoII sites were imposed by ligands flanked with fused benzene rings on both sides, compromising such extra-sites enhancement.	Carbon Dioxide	240-243	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	337-341
30129103-3	2018	In the catalytic conversion of CO2 with propylene oxide to form propylene carbonate, the as-synthesized MOF-74-III(Co) with desired properties of highly exposed and accessible open CoII centers, large mesopore apertures and multi-interactive sites, demonstrated higher catalytic activity compared with other two MOFs, with benzene rings fused to ligands hampering the functionality of CoII centers as Lewis acid sites.	Carbon Dioxide	31-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	181-185
30129103-3	2018	In the catalytic conversion of CO2 with propylene oxide to form propylene carbonate, the as-synthesized MOF-74-III(Co) with desired properties of highly exposed and accessible open CoII centers, large mesopore apertures and multi-interactive sites, demonstrated higher catalytic activity compared with other two MOFs, with benzene rings fused to ligands hampering the functionality of CoII centers as Lewis acid sites.	Carbon Dioxide	31-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	385-389
30129103-3	2018	In the catalytic conversion of CO2 with propylene oxide to form propylene carbonate, the as-synthesized MOF-74-III(Co) with desired properties of highly exposed and accessible open CoII centers, large mesopore apertures and multi-interactive sites, demonstrated higher catalytic activity compared with other two MOFs, with benzene rings fused to ligands hampering the functionality of CoII centers as Lewis acid sites.	propylene oxide	40-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	181-185
30129103-3	2018	In the catalytic conversion of CO2 with propylene oxide to form propylene carbonate, the as-synthesized MOF-74-III(Co) with desired properties of highly exposed and accessible open CoII centers, large mesopore apertures and multi-interactive sites, demonstrated higher catalytic activity compared with other two MOFs, with benzene rings fused to ligands hampering the functionality of CoII centers as Lewis acid sites.	propylene oxide	40-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	385-389
30129103-3	2018	In the catalytic conversion of CO2 with propylene oxide to form propylene carbonate, the as-synthesized MOF-74-III(Co) with desired properties of highly exposed and accessible open CoII centers, large mesopore apertures and multi-interactive sites, demonstrated higher catalytic activity compared with other two MOFs, with benzene rings fused to ligands hampering the functionality of CoII centers as Lewis acid sites.	propylene carbonate	64-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	181-185
30129103-3	2018	In the catalytic conversion of CO2 with propylene oxide to form propylene carbonate, the as-synthesized MOF-74-III(Co) with desired properties of highly exposed and accessible open CoII centers, large mesopore apertures and multi-interactive sites, demonstrated higher catalytic activity compared with other two MOFs, with benzene rings fused to ligands hampering the functionality of CoII centers as Lewis acid sites.	propylene carbonate	64-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	385-389
30314699-10	2018	miR-101 was shown to directly bind 3"-UTR of COX-2 and downregulate COX-2 expression.	mir-101	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-50
30314699-10	2018	miR-101 was shown to directly bind 3"-UTR of COX-2 and downregulate COX-2 expression.	mir-101	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-73
30314699-11	2018	Finally, COX-2 overexpression was demonstrated to rescue the tumor phenotypes of nasopharyngeal carcinoma cells attenuated by HOTAIR knockdown or miR-101 mimic.	mir-101	146-153	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	9-14
30424016-3	2018	However, if thiazolidinediones are combined with additional regulatory active drugs, so-called "master modulators" of tumors, i.e., transcriptional modulators, metronomic low-dose chemotherapy, epigenetically modifying agents, protein binding pro-anakoinotic drugs, such as COX-2 inhibitors, IMiDs, etc., the results indicate clinically relevant communicative reprogramming of tumor tissues, i.e., anakoinosis, meaning "communication" in ancient Greek.	Thiazolidinediones	12-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	274-279
30339376-1	2018	Chiroptical broad-range spectral analysis extending from UV to mid-IR was employed to study a family of Co(II) N-(1-(aryl)ethyl)salicylaldiminato Schiff base complexes with pseudotetrahedral geometry associated with chirality-at-metal of the Delta/Lambda type.	n-(1-(aryl)ethyl)salicylaldiminato schiff base	111-157	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
30357236-1	2018	We present a Ag(i)/Co(ii) co-catalyzed tandem fragmentation and recombination reaction commencing from detachable nonaflates and amidines.	Amidines	129-137	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-25
30265541-8	2018	As a result, a mutation of IKKbetaC179A rescued the therapeutic effect of UA on Ti-particle-induced inflammation, including morphological transforms, upregulation of iNOS and COX-2, increased secretions of TNF-alpha, IL-1beta, and IL-6, and decreased secretion of IL-10.	ursolic acid	74-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	175-180
30251689-2	2018	We have described that BACE1 is involved in the lysophosphatidylethanolamine (LPE) (18:1/20:4/22:6) upregulation associated with tauopathy and inflammation signaling (cPLA2/arachidonic acid/COX2) in a triple transgenic model of Alzheimer"s disease, where BACE1 silencing reversed the imbalanced profile and produced cognitive function improvement.	lysophosphatidylethanolamine	48-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	190-194
30351068-3	2018	Available alkoxido arms of the initially formed {L(mu1,3-O2CCH3)(mu-OH/OMe)Co2}+ fragments were utilized to trap a central CoII ion during the formation of [Co5] aggregates.	{l(mu1,3-o2cch3)	48-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-127
30351068-3	2018	Available alkoxido arms of the initially formed {L(mu1,3-O2CCH3)(mu-OH/OMe)Co2}+ fragments were utilized to trap a central CoII ion during the formation of [Co5] aggregates.	mu-oh	65-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-127
30351068-3	2018	Available alkoxido arms of the initially formed {L(mu1,3-O2CCH3)(mu-OH/OMe)Co2}+ fragments were utilized to trap a central CoII ion during the formation of [Co5] aggregates.	N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)-4-((4-fluorobenzyl)oxy)pyridine-2,6-dicarboxamide	75-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-127
30351068-3	2018	Available alkoxido arms of the initially formed {L(mu1,3-O2CCH3)(mu-OH/OMe)Co2}+ fragments were utilized to trap a central CoII ion during the formation of [Co5] aggregates.	co5	157-160	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-127
30251689-2	2018	We have described that BACE1 is involved in the lysophosphatidylethanolamine (LPE) (18:1/20:4/22:6) upregulation associated with tauopathy and inflammation signaling (cPLA2/arachidonic acid/COX2) in a triple transgenic model of Alzheimer"s disease, where BACE1 silencing reversed the imbalanced profile and produced cognitive function improvement.	lysophosphatidylethanolamine	78-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	190-194
29796776-6	2018	After DHA treatment, the mRNA and protein levels of COX-2 were strikingly upregulated in time- and dose-dependent manners.	artenimol	6-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-57
30429487-6	2018	In addition, a single intra-discal injection of NTG-101 into the injured IVD-NPs resulted in sustained expression of healthy extra-cellular matrix (ECM) proteins (aggrecan, collagen 2A1) and reduced expression of inflammation associated proteins and molecules (IL-1beta, IL-6, IL-8, MMP-13, Cox-2 and PGE2) as compared to vehicle controls.	ntg-101	48-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	291-296
29975000-8	2018	Then, we confirmed these gene expressions using qRT-PCR, and the protein levels of mitogen-activated protein kinases and COX-2 with progesterone decreased using western blotting and enzyme-linked immunosorbent assay.	Progesterone	132-144	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-126
29796776-8	2018	As expected, inhibition of COX-1 or COX-2 further reduced PGE2 production after DHA treatment.	Dinoprostone	58-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-41
30142469-6	2018	Cardamonin inhibited NF-kappaB activation as well as COX-2 expression induced by TLR agonists.	cardamonin	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-58
30125599-6	2018	G31P treatment also had repressing effect on the inflammatory associated enzymes COX-2, MMP-2, and MMP-9.	g31p	0-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-86
30172103-5	2018	The results showed that treatment of abietic acid significantly inhibited IL-1beta-induced TNF-alpha, NO, PGE2 production, and COX-2 expression.	abietic acid	37-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	127-132
30261465-6	2018	Levels of IL-1beta-induced inflammatory biomarkers including TNF-alpha, COX-2, IL-6 and iNOS were reduced by Co-Q10, which was possibly associated with inhibition of NF-kappaB signaling activation.	coenzyme Q10	109-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
30076654-5	2018	In the current study, we identified that DMY attenuated lipopolysaccharide (LPS)-induced oxidative stress through inhibiting the production of reactive oxygen species (ROS) and nitric oxide (NO), downregulated COX-2 and iNOS, and promoted the activity of the antioxidative system by activating superoxide dismutase (SOD) and Nrf2/HO-1 pathway.	dihydromyricetin	41-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	210-215
30402023-0	2018	6-Shogaol reduces progression of experimental endometriosis in vivo and in vitro via regulation of VGEF and inhibition of COX-2 and PGE2-mediated inflammatory responses.	shogaol	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-127
30402023-12	2018	Overall, the results of the study reveal the efficacy of 6-shogaol against endometriosis via effectively suppressing proliferation of the lesions and modulating angiogenesis and COX-2/NF-kappaB-mediated inflammatory cascades.	shogaol	57-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	178-183
30383755-12	2018	The relative risk was highest for ketorolac and was correlated with COX-2 potency, but not restricted to coxibs.	Ketorolac	34-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-73
30429830-4	2018	In this study, gene expression analyses indicated that genes involved in eicosanoid biosynthesis including COX-1, COX-2, DAGL, and PLA-2 are differentially regulated in THP-1 human macrophages infected with Salmonella enterica Typhimurium or Yersinia enterocolitica.	Eicosanoids	73-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-119
30303221-4	2018	One-electron oxidation of 1 by silver triflate produces the [(imSQC(O)Ph)CoII(imQC(O)Ph)]OTf 2toluene (2) derivative with the trigonal prismatic coordination environment of the metal arising from the additional coordination of -C(O)Ph hemilabile groups.	trifluoromethanesulfonic acid	31-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-77
30303221-4	2018	One-electron oxidation of 1 by silver triflate produces the [(imSQC(O)Ph)CoII(imQC(O)Ph)]OTf 2toluene (2) derivative with the trigonal prismatic coordination environment of the metal arising from the additional coordination of -C(O)Ph hemilabile groups.	2toluene	93-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-77
30303221-4	2018	One-electron oxidation of 1 by silver triflate produces the [(imSQC(O)Ph)CoII(imQC(O)Ph)]OTf 2toluene (2) derivative with the trigonal prismatic coordination environment of the metal arising from the additional coordination of -C(O)Ph hemilabile groups.	Metals	177-182	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-77
30303221-7	2018	Chemical oxidation of complex 1 promotes the reduction of CoIII to CoII in compound 2 due to the redox-active nature of o-iminobenzoquinonate ligands.	o-iminobenzoquinonate	120-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-62
30374304-11	2018	Among these compounds, six were found to be interacting with the binding site for arachidonic acid in COX-2 enzyme.	Arachidonic Acid	82-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-107
29796776-8	2018	As expected, inhibition of COX-1 or COX-2 further reduced PGE2 production after DHA treatment.	artenimol	80-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-41
30295298-4	2018	X-ray analysis and spectroscopy characterization revealed the differences between the isolated compounds: 1D polymeric chains (CPs) with carboranylphosphinate ligand bridges have been obtained with MnII, CdII or ZnII centres, whereas compounds with low nuclearity have been isolated with CuII, CoII and NiII.	cps	127-130	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	294-298
30295298-5	2018	No polymeric structures were obtained in the CoII and NiII complexes due to the higher affinity of these metals for water than that for the m-carboranylphosphinate and accordingly, these complexes generate supramolecular hydrophobic/hydrophilic structures.	Water	116-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-49
30295298-5	2018	No polymeric structures were obtained in the CoII and NiII complexes due to the higher affinity of these metals for water than that for the m-carboranylphosphinate and accordingly, these complexes generate supramolecular hydrophobic/hydrophilic structures.	m-carboranylphosphinate	140-163	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-49
30426038-0	2018	Electrochemical data of Co(II) complexes containing phenanthroline functionalized ligands.	Phenanthrolines	52-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-30
30426038-1	2018	The data presented in this paper are related to the research article entitled "Electrochemical properties of a series of Co(II) complexes, containing substituted phenanthrolines" (Ferreira et al., 2018) [1].	Phenanthrolines	162-177	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-127
30426038-2	2018	This paper presents detailed electrochemical data of eight octahedral Co(II) complexes containing functionalized phenanthrolines-ligands.	Phenanthrolines	113-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-76
30426038-3	2018	The data illustrate the shift in the CoIII/II and CoII/I redox couples due to different substituents on the phenanthrolines.	Phenanthrolines	108-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-41
30084121-0	2018	Tuning of High Spin Ground State and Slow Magnetic Relaxation within Trimetallic Cyanide-Bridged {NiII x CoII 9-x [WV (CN)8 ]6 } and {MnII x CoII 9-x [WV (CN)8 ]6 } Clusters.	trimetallic cyanide	69-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-109
30084121-7	2018	The values of DeltaE are correlated with possible anisotropy of distribution of fac-[CoII (mu-NC)3 (MeOH)3 ] moieties at the external corners of the cube substructure.	Methanol	100-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-89
29407194-4	2018	A selective alpha1-ADR agonist, phenylephrine, increased intracellular Ca2+-levels in cultured HTPCs and induced COX-2, IL-6 and MCP-1 mRNA expression without affecting IL-1beta mRNA.	Phenylephrine	32-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-118
30314513-12	2018	Our further explorations demonstrated that Andro inhibited the binding of the transactivators CREB2, C-Fos and NF-kappaB and blocked the recruitment of coactivator p300 to COX-2 promoter.	andrographolide	43-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	172-177
30207688-6	2018	Octahedral metal ions, such as FeII, CoII, NiII, ZnII, and CdII, constitute the vertices.	Metals	11-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-41
30153531-2	2018	VA692, a recently disclosed selective COX-2 inhibitor, structurally related to well-known marketed coxibs, showed anti-inflammatory, and anti-nociceptive properties.	va692	0-5	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-43
30092374-7	2018	50 muM LPA increased the mRNA expressions of COX-2 and iNOS enzymes which were attenuated by the treatment of LPAR1/3 antagonist Ki16425.	lysophosphatidic acid	7-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-50
30092374-7	2018	50 muM LPA increased the mRNA expressions of COX-2 and iNOS enzymes which were attenuated by the treatment of LPAR1/3 antagonist Ki16425.	3-(4-(4-((1-(2-chlorophenyl)ethoxy)carbonyl amino)-3-methyl-5-isoxazolyl) benzylsulfanyl) propanoic acid	129-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-50
30092374-9	2018	LPA also enhanced the PGE2 to PGF2alpha ratio in uterine tissue homogenates which was inhibited by all the receptor antagonists as well as by the inhibitors of COX-2 and iNOS.	lysophosphatidic acid	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	160-165
30092374-9	2018	LPA also enhanced the PGE2 to PGF2alpha ratio in uterine tissue homogenates which was inhibited by all the receptor antagonists as well as by the inhibitors of COX-2 and iNOS.	Dinoprostone	22-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	160-165
30092374-9	2018	LPA also enhanced the PGE2 to PGF2alpha ratio in uterine tissue homogenates which was inhibited by all the receptor antagonists as well as by the inhibitors of COX-2 and iNOS.	Dinoprost	30-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	160-165
30314310-1	2018	Prostaglandins and thromboxane are lipid signaling molecules deriving from arachidonic acid by the action of the cyclooxygenase isoenzymes COX-1 and COX-2.	Prostaglandins	0-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	149-154
30226522-2	2018	Herein, two hydroxy-rich hydrazone-based COFs are synthesized in pure water and postsynthetically incorporated with CoII, exhibiting Lewis acid catalytic activity towards cyanosilylation of various aldehydes with size selectivity.	hydroxy-rich hydrazone	12-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-120
30226522-2	2018	Herein, two hydroxy-rich hydrazone-based COFs are synthesized in pure water and postsynthetically incorporated with CoII, exhibiting Lewis acid catalytic activity towards cyanosilylation of various aldehydes with size selectivity.	Water	70-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-120
30226522-2	2018	Herein, two hydroxy-rich hydrazone-based COFs are synthesized in pure water and postsynthetically incorporated with CoII, exhibiting Lewis acid catalytic activity towards cyanosilylation of various aldehydes with size selectivity.	Lewis Acids	133-143	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-120
30226522-2	2018	Herein, two hydroxy-rich hydrazone-based COFs are synthesized in pure water and postsynthetically incorporated with CoII, exhibiting Lewis acid catalytic activity towards cyanosilylation of various aldehydes with size selectivity.	Aldehydes	198-207	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-120
30314310-1	2018	Prostaglandins and thromboxane are lipid signaling molecules deriving from arachidonic acid by the action of the cyclooxygenase isoenzymes COX-1 and COX-2.	Thromboxanes	19-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	149-154
30314310-1	2018	Prostaglandins and thromboxane are lipid signaling molecules deriving from arachidonic acid by the action of the cyclooxygenase isoenzymes COX-1 and COX-2.	Arachidonic Acid	75-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	149-154
30216848-0	2018	Structural alterations based on naproxen scaffold: Synthesis, evaluation of antitumor activity and COX-2 inhibition, and molecular docking.	Naproxen	32-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-104
30349293-8	2018	For this purpose, several drugs may have a role: specific COX-2 inhibitors such as celecoxib or other anti-inflammatory drugs such as lenalidomide may further inhibit lipopolysaccharide-mediated induction of COX-2.	Celecoxib	83-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
30349293-8	2018	For this purpose, several drugs may have a role: specific COX-2 inhibitors such as celecoxib or other anti-inflammatory drugs such as lenalidomide may further inhibit lipopolysaccharide-mediated induction of COX-2.	Celecoxib	83-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	208-213
30349293-8	2018	For this purpose, several drugs may have a role: specific COX-2 inhibitors such as celecoxib or other anti-inflammatory drugs such as lenalidomide may further inhibit lipopolysaccharide-mediated induction of COX-2.	Lenalidomide	134-146	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
30349293-8	2018	For this purpose, several drugs may have a role: specific COX-2 inhibitors such as celecoxib or other anti-inflammatory drugs such as lenalidomide may further inhibit lipopolysaccharide-mediated induction of COX-2.	Lenalidomide	134-146	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	208-213
30349293-9	2018	Moreover, lenalidomide and COX-2 inhibitors (celecoxib) have been tested in solid tumors with encouraging results.	Celecoxib	45-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-32
30216848-5	2018	Furthermore, in vitro COX-1/COX-2 inhibition testing showed that the compounds 4b, 6c, 10b, and 10c exhibited effective COX-2 inhibition, with IC50 values of 0.40-1.20 muM, and selectivity index (SI) values of &gt;62.50-20.83, using celecoxib as a reference drug (IC50 = 0.11 muM; COX-2 SI: &gt;227.20).	Celecoxib	233-242	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-125
30216848-5	2018	Furthermore, in vitro COX-1/COX-2 inhibition testing showed that the compounds 4b, 6c, 10b, and 10c exhibited effective COX-2 inhibition, with IC50 values of 0.40-1.20 muM, and selectivity index (SI) values of &gt;62.50-20.83, using celecoxib as a reference drug (IC50 = 0.11 muM; COX-2 SI: &gt;227.20).	Celecoxib	233-242	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-125
29922878-2	2018	It is reported to covalently modify COX-2 enzyme by acetylating a serine amino acid residue.	serine amino acid	66-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-41
30174297-5	2018	In contrast, darkness-induced TNF increases melatonin secretion to drive renewal of HSPCs and LT-HSC potential through modulating surface CD150 and c-Kit expression, increasing COX-2/alphaSMA+ macrophages, diminishing vascular permeability, and reducing HSPC ROS levels.	Melatonin	44-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	177-182
30284977-0	2018	A new two-dimensional CoII coordination polymer based on bis[4-(2-methyl-1H-imidazol-1-yl)phenyl] ether and biphenyl-4,4"-diyldicarboxylic acid: synthesis, crystal structure and photocatalytic degradation activity.	Polymers	40-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-26
30284977-0	2018	A new two-dimensional CoII coordination polymer based on bis[4-(2-methyl-1H-imidazol-1-yl)phenyl] ether and biphenyl-4,4"-diyldicarboxylic acid: synthesis, crystal structure and photocatalytic degradation activity.	bis[4-(2-methyl-1h-imidazol-1-yl)phenyl] ether	57-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-26
30284977-0	2018	A new two-dimensional CoII coordination polymer based on bis[4-(2-methyl-1H-imidazol-1-yl)phenyl] ether and biphenyl-4,4"-diyldicarboxylic acid: synthesis, crystal structure and photocatalytic degradation activity.	biphenyl-4,4"-diyldicarboxylic acid	108-143	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-26
30314513-0	2018	Andrographolide inhibits breast cancer through suppressing COX-2 expression and angiogenesis via inactivation of p300 signaling and VEGF pathway.	andrographolide	0-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-64
30142577-9	2018	Cellulose/HO7Sb3 exhibits selectivity for La (III), Co (II) and Cs (I) in the order of La3+ &gt; Co2+ &gt; Cs+.	Cellulose	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-59
30142577-9	2018	Cellulose/HO7Sb3 exhibits selectivity for La (III), Co (II) and Cs (I) in the order of La3+ &gt; Co2+ &gt; Cs+.	ho7sb3	10-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-59
30142577-9	2018	Cellulose/HO7Sb3 exhibits selectivity for La (III), Co (II) and Cs (I) in the order of La3+ &gt; Co2+ &gt; Cs+.	la3+ &gt	87-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-59
30142577-9	2018	Cellulose/HO7Sb3 exhibits selectivity for La (III), Co (II) and Cs (I) in the order of La3+ &gt; Co2+ &gt; Cs+.	Cobalt(2+)	97-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-59
30119184-8	2018	In addition, scoparone repressed IL-1beta-induced the expression of iNOS and COX-2 in chondrocytes.	scoparone	13-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-82
30142577-9	2018	Cellulose/HO7Sb3 exhibits selectivity for La (III), Co (II) and Cs (I) in the order of La3+ &gt; Co2+ &gt; Cs+.	Cesium	107-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-59
30005203-0	2018	Design, synthesis of novel isoindoline hybrids as COX-2 inhibitors: Anti-inflammatory, analgesic activities and docking study.	2-(3-hydroxypropyl)isoindoline-1,3-dione	27-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-55
30005203-6	2018	The moderate selective COX-2 inhibitor; dimethoxychalcone 11d (SI = 103) displayed excellent anti-inflammatory activity (% edema inhibition = 45.8-59.3) and increased thermal pain threshold (50-92.85%) comparable to piroxicam (75%).	dimethoxychalcone	40-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-28
30005203-6	2018	The moderate selective COX-2 inhibitor; dimethoxychalcone 11d (SI = 103) displayed excellent anti-inflammatory activity (% edema inhibition = 45.8-59.3) and increased thermal pain threshold (50-92.85%) comparable to piroxicam (75%).	Piroxicam	216-225	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-28
30106307-9	2018	Also, it possessed better affinity value, -7.80518 kcal/mol and energy binding -85.08 kcal/mol, in inhibition of COX-2 with PDB Id: 1CVU rather than other compounds and significantly the higher dock score than aspirin, close to celecoxib.	Aspirin	210-217	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-118
30106307-9	2018	Also, it possessed better affinity value, -7.80518 kcal/mol and energy binding -85.08 kcal/mol, in inhibition of COX-2 with PDB Id: 1CVU rather than other compounds and significantly the higher dock score than aspirin, close to celecoxib.	Celecoxib	228-237	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-118
29951871-5	2018	The results showed that taraxasterol not only reduced the production of TNF-alpha, IL-8, PGE2, and NO induced by LPS, but also reduced the expression of iNOS and COX-2.	taraxasterol	24-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	162-167
30027502-4	2018	Resveratrol is a stilbenoid phytoalexin which binds to a specific site on the cell surface integrin alphavbeta3 to trigger cancer cell death via nuclear translocation of COX-2.	Resveratrol	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	170-175
30027502-4	2018	Resveratrol is a stilbenoid phytoalexin which binds to a specific site on the cell surface integrin alphavbeta3 to trigger cancer cell death via nuclear translocation of COX-2.	stilbenoid	17-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	170-175
30027502-4	2018	Resveratrol is a stilbenoid phytoalexin which binds to a specific site on the cell surface integrin alphavbeta3 to trigger cancer cell death via nuclear translocation of COX-2.	phytoalexins	28-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	170-175
30027502-6	2018	This unanticipated effect inhibits resveratrol-induced COX-2 nuclear accumulation.	Resveratrol	35-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-60
30027502-7	2018	RRM2 downregulation, whether achieved by RNA interference or treatment with NDAT, enhanced resveratrol-induced COX-2 gene expression and nuclear uptake which is essential to integrin alphavbeta3-mediated-resveratrol-induced antiproliferation in cancer cells.	nano-diamino-tetrac	76-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	111-116
30027502-7	2018	RRM2 downregulation, whether achieved by RNA interference or treatment with NDAT, enhanced resveratrol-induced COX-2 gene expression and nuclear uptake which is essential to integrin alphavbeta3-mediated-resveratrol-induced antiproliferation in cancer cells.	Resveratrol	91-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	111-116
30012671-5	2018	Reduction of RIPK3 in MDSC and colorectal cancer cells elicited NFkappaB-transcribed COX-2, which catalyzed the synthesis of prostaglandin E2 (PGE2).	Dinoprostone	125-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-90
30012671-5	2018	Reduction of RIPK3 in MDSC and colorectal cancer cells elicited NFkappaB-transcribed COX-2, which catalyzed the synthesis of prostaglandin E2 (PGE2).	Dinoprostone	143-147	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-90
30012671-7	2018	Moreover, PGE2 suppressed RIPK3 expression while enhancing expression of NFkappaB and COX-2 in MDSCs and colorectal cancer cells.	Dinoprostone	10-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-91
30026090-7	2018	Expressions of proapoptotic genes, such as cyclooxygenase (COX)-2, p21 and CDKN2, were induced by resveratrol in myoma cells.	Resveratrol	98-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-65
29961171-7	2018	Overall, curcumin alleviates the airway inflammation and airway remolding, which is closely related to inhibit the BEAS-2B cells proliferation and suppress the activation of NF-kappaB and COX-2 expression.	Curcumin	9-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	188-193
30098223-8	2018	Furthermore, we demonstrate here that increased levels of apolipoprotein A1 (APOA1), a protein involved in cholesterol efflux and high-density lipoprotein constitution, in the extracellular compartment modulates expression of ABCA1 by regulating COX-2, and compensate for ABCA1-dependent excessive export of cholesterol.	Cholesterol	308-319	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	246-251
30568687-0	2018	Design, Synthesis and Biological Evaluation of New Imidazo[2,1-b]Thiazole Derivatives as Selective COX-2 Inhibitors.	imidazo(2,1-b)thiazole	51-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-104
30568687-1	2018	A new series of imidazo[2,1-b]thiazole analogs containing a methyl sulfonyl COX-2 pharmacophore was synthesized and evaluated for their COX-2 inhibitory activity.	imidazo(2,1-b)thiazole	16-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-81
30568687-1	2018	A new series of imidazo[2,1-b]thiazole analogs containing a methyl sulfonyl COX-2 pharmacophore was synthesized and evaluated for their COX-2 inhibitory activity.	imidazo(2,1-b)thiazole	16-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	136-141
30568687-3	2018	These results indicated that both potency and selectivity of COX-2 inhibitory activity were affected by the type and size of amine on C-5 of imidazo[2,1-b]thiazole ring.	Amines	125-130	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-66
30568687-3	2018	These results indicated that both potency and selectivity of COX-2 inhibitory activity were affected by the type and size of amine on C-5 of imidazo[2,1-b]thiazole ring.	imidazo(2,1-b)thiazole	141-163	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-66
30568687-4	2018	Our data identified N,N-dimethyl-1-(6-(4-(methylsulfonyl)phenyl)imidazo[2,1-b]thiazol-5-yl)methanamine (6a) as a potent and selective COX-2 inhibitor (IC50 COX-1 &gt;100 microM; IC50 COX-2 = 0.08 microM; selectivity index = 313.7).	n,n-dimethyl-1-(6-(4-(methylsulfonyl)phenyl)imidazo[2,1-b]thiazol-5-yl)methanamine	20-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-139
30568687-4	2018	Our data identified N,N-dimethyl-1-(6-(4-(methylsulfonyl)phenyl)imidazo[2,1-b]thiazol-5-yl)methanamine (6a) as a potent and selective COX-2 inhibitor (IC50 COX-1 &gt;100 microM; IC50 COX-2 = 0.08 microM; selectivity index = 313.7).	n,n-dimethyl-1-(6-(4-(methylsulfonyl)phenyl)imidazo[2,1-b]thiazol-5-yl)methanamine	20-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	183-188
30568687-5	2018	Our results indicated that both potency and selectivity of COX-2 inhibitory activity were affected by the type and size of amine on C-5 of imidazo[2,1-b]thiazole ring.	Amines	123-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-64
30568687-5	2018	Our results indicated that both potency and selectivity of COX-2 inhibitory activity were affected by the type and size of amine on C-5 of imidazo[2,1-b]thiazole ring.	imidazo(2,1-b)thiazole	139-161	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-64
30276484-1	2018	A composite was prepared from a Co(II)-based zeolitic imidazolate framework (ZIF-67) and graphene oxide (GO) by an in situ growth method.	zeolitic imidazolate	45-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-37
30276484-1	2018	A composite was prepared from a Co(II)-based zeolitic imidazolate framework (ZIF-67) and graphene oxide (GO) by an in situ growth method.	zif	77-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-37
30276484-1	2018	A composite was prepared from a Co(II)-based zeolitic imidazolate framework (ZIF-67) and graphene oxide (GO) by an in situ growth method.	graphene oxide	89-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-37
30276484-10	2018	GO: graphene oxide; ZIF-67: Co(II)-based zeolitic imidazolate framework.	graphene oxide	0-2	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
30276484-10	2018	GO: graphene oxide; ZIF-67: Co(II)-based zeolitic imidazolate framework.	graphene oxide	4-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
30276484-10	2018	GO: graphene oxide; ZIF-67: Co(II)-based zeolitic imidazolate framework.	zif	20-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
30276484-10	2018	GO: graphene oxide; ZIF-67: Co(II)-based zeolitic imidazolate framework.	zeolitic imidazolate	41-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
30276484-0	2018	Electrochemical determination of dopamine and uric acid using a glassy carbon electrode modified with a composite consisting of a Co(II)-based metalorganic framework (ZIF-67) and graphene oxide.	Dopamine	33-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	130-135
30102465-10	2018	PA enhances the expression of MCP-1, IL-6, and COX-2 genes, while POA downregulates these genes, decreases expression of NFkappaB, and upregulates PPAR-alpha gene expression.	Palmitic Acid	0-2	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
29980010-8	2018	Additionally, key signaling molecules involved in the upregulation of COX-2, a critical enzyme in the synthesis of the inflammatory mediator prostaglandin, were elevated.	Prostaglandins	141-154	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-75
30293595-7	2018	COX2 is an inducible COX isoform and that plays an important role in inflammatory process by leading the synthesis of pro- and anti- inflammatory prostaglandins.	Prostaglandins	146-160	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-4
29786910-5	2018	Immunoblotting experiments also revealed that agathisflavone reduced levels of iNOS and COX-2 protein.	agathisflavone	46-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-93
30118206-0	2018	Self-Inhibitory Electron Transfer of the Co(III)/Co(II)-Complex Redox Couple at Pristine Carbon Electrode.	Carbon	89-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-46
30157382-7	2018	Structural changes associated with the TCC isomer induces formation of the high-spin Co(II) form, suggesting that magnetization dymanics can occur along the excited-state PES, leading to ultrafast switching on the ps time scale.	Triclocarban	39-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-91
30204436-3	2018	The amount of Co(II)aq in 500 muM solutions of each Co-POM was measured after 3 h of aging as well as from t = 0 for pH = 5.8 and 8.0 by muM sensitive Co(II)aq-induced 31P NMR line broadening and at pH = 9.0 by cathodic stripping.	ET bromodomain inhibitor	168-171	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-20
30204436-3	2018	The amount of Co(II)aq in 500 muM solutions of each Co-POM was measured after 3 h of aging as well as from t = 0 for pH = 5.8 and 8.0 by muM sensitive Co(II)aq-induced 31P NMR line broadening and at pH = 9.0 by cathodic stripping.	ET bromodomain inhibitor	168-171	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
30204436-4	2018	The amount of detectable Co(II)aq after 3 h for the six Co-POMs ranges from ~0.25 to ~90% of the total cobalt initially present in the Co-POM.	Cobalt	103-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-30
30204436-5	2018	For 12 out of 18 total Co-POM and different pH cases, the amount Co(II)aq detected after 3 h forms heterogeneous CoO x able to account for &gt;=100% of the observed WOCatalysis activity.	co-pom	23-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-70
30204436-5	2018	For 12 out of 18 total Co-POM and different pH cases, the amount Co(II)aq detected after 3 h forms heterogeneous CoO x able to account for &gt;=100% of the observed WOCatalysis activity.	coo x	113-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-70
30204436-6	2018	However, under 0.1 M NaPi, pH 5.8 conditions for CoPW11 and alpha1-CoP2W17 where ~1.5% and 0.25% Co(II)aq is detectable, the measured Co(II)aq cannot account for the observed WOCatalysis.	napi	21-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-139
30009517-3	2018	Time-resolved Co K-edge X-ray absorption spectroscopy in the microsecond time range indicates that, for the [CoII (aPPy)] catalyst (aPPy=di([2,2"-bipyridin]-6-yl)(pyridin-2-yl)methanol), the pendant pyridine dissociates from the cobalt in the intermediate CoI state.	di([2,2"-bipyridin]-6-yl)(pyridin-2-yl)methanol	137-184	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-113
30009517-3	2018	Time-resolved Co K-edge X-ray absorption spectroscopy in the microsecond time range indicates that, for the [CoII (aPPy)] catalyst (aPPy=di([2,2"-bipyridin]-6-yl)(pyridin-2-yl)methanol), the pendant pyridine dissociates from the cobalt in the intermediate CoI state.	pyridine	199-207	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-113
30009517-3	2018	Time-resolved Co K-edge X-ray absorption spectroscopy in the microsecond time range indicates that, for the [CoII (aPPy)] catalyst (aPPy=di([2,2"-bipyridin]-6-yl)(pyridin-2-yl)methanol), the pendant pyridine dissociates from the cobalt in the intermediate CoI state.	Cobalt	229-235	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-113
30009517-5	2018	In the resting state, the catalyst returns to the original six-coordinate high-spin CoII state with a pentapyridyl and one water molecule coordinating to the metal center.	Water	123-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-88
30009517-5	2018	In the resting state, the catalyst returns to the original six-coordinate high-spin CoII state with a pentapyridyl and one water molecule coordinating to the metal center.	Metals	158-163	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-88
30288088-6	2018	The meta-analysis showed no significant difference between celecoxib and ns-NSAIDs in the rate of acute myocardial infarction, and celecoxib was the only COX2-selective NSAID with a lower risk of adverse CV and GI events vs ns-NSAIDs.	Celecoxib	131-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	154-158
29964012-5	2018	Mechanistically, using luciferase reporter and chromatin immunoprecipitation assays, we identified prostaglandin-endoperoxide synthase 2 (PTGS2, also called COX2), a potent enzyme responsible for prostanoids formation and inflammatory response, as the direct down-stream target of PAX5.	Prostaglandins	196-207	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	157-161
30118206-3	2018	Herein, we employ nanoscale scanning electrochemical microscopy (SECM) and cyclic voltammetry to gain new insights into the interplay between heterogeneous ET and adsorption of a Co(III)/Co(II)-complex redox couple at the contamination-free surface of electron-beam-deposited carbon (eC).	Carbon	276-282	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	179-184
30124288-0	2018	Additive-Induced Supramolecular Isomerism and Enhancement of Robustness in Co(II)-Based MOFs for Efficiently Trapping Acetylene from Acetylene-Containing Mixtures.	Acetylene	118-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
30344915-2	2018	The majority of these derivatives preferentially inhibit hCA isoforms II and XII and hCOX-2 isozyme, indicating that 2,3,4-trisubstituted 2,3-dihydrothiazoles are a promising scaffold for the inhibition of hCA isozymes and of hCOX-2 enzyme.	2,3,4-trisubstituted	117-137	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-91
30344915-2	2018	The majority of these derivatives preferentially inhibit hCA isoforms II and XII and hCOX-2 isozyme, indicating that 2,3,4-trisubstituted 2,3-dihydrothiazoles are a promising scaffold for the inhibition of hCA isozymes and of hCOX-2 enzyme.	2,3,4-trisubstituted	117-137	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	226-232
30344915-2	2018	The majority of these derivatives preferentially inhibit hCA isoforms II and XII and hCOX-2 isozyme, indicating that 2,3,4-trisubstituted 2,3-dihydrothiazoles are a promising scaffold for the inhibition of hCA isozymes and of hCOX-2 enzyme.	2,3-dihydrothiazole	138-158	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-91
30344915-2	2018	The majority of these derivatives preferentially inhibit hCA isoforms II and XII and hCOX-2 isozyme, indicating that 2,3,4-trisubstituted 2,3-dihydrothiazoles are a promising scaffold for the inhibition of hCA isozymes and of hCOX-2 enzyme.	2,3-dihydrothiazole	138-158	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	226-232
29608639-2	2018	Concomitant use of selective cyclooxygenase (COX)-2 inhibitor celecoxib and anticonvulsant gabapentin have been proposed to adequately control acute postoperative pain.	Celecoxib	62-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-51
30066702-4	2018	This feature article highlights the development of additions to ketimines catalyzed by these three metals, that is, (i) Pd(ii)-catalyzed enantioselective additions of arylboronic acids to ketimines, (ii) Ni(ii)-catalyzed enantioselective additions of arylboronic and alkenylboronic acids to ketimines, and (iii) Co(ii)-catalyzed enantioselective additions of potassium allyltrifluoroborate to ketimines.	arylboronic acids	167-184	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	312-317
30066702-4	2018	This feature article highlights the development of additions to ketimines catalyzed by these three metals, that is, (i) Pd(ii)-catalyzed enantioselective additions of arylboronic acids to ketimines, (ii) Ni(ii)-catalyzed enantioselective additions of arylboronic and alkenylboronic acids to ketimines, and (iii) Co(ii)-catalyzed enantioselective additions of potassium allyltrifluoroborate to ketimines.	ketimine	188-197	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-125
30066702-4	2018	This feature article highlights the development of additions to ketimines catalyzed by these three metals, that is, (i) Pd(ii)-catalyzed enantioselective additions of arylboronic acids to ketimines, (ii) Ni(ii)-catalyzed enantioselective additions of arylboronic and alkenylboronic acids to ketimines, and (iii) Co(ii)-catalyzed enantioselective additions of potassium allyltrifluoroborate to ketimines.	ketimine	188-197	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	312-317
30066702-4	2018	This feature article highlights the development of additions to ketimines catalyzed by these three metals, that is, (i) Pd(ii)-catalyzed enantioselective additions of arylboronic acids to ketimines, (ii) Ni(ii)-catalyzed enantioselective additions of arylboronic and alkenylboronic acids to ketimines, and (iii) Co(ii)-catalyzed enantioselective additions of potassium allyltrifluoroborate to ketimines.	arylboronic	167-178	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-125
30066702-4	2018	This feature article highlights the development of additions to ketimines catalyzed by these three metals, that is, (i) Pd(ii)-catalyzed enantioselective additions of arylboronic acids to ketimines, (ii) Ni(ii)-catalyzed enantioselective additions of arylboronic and alkenylboronic acids to ketimines, and (iii) Co(ii)-catalyzed enantioselective additions of potassium allyltrifluoroborate to ketimines.	arylboronic	167-178	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	200-202
30066702-4	2018	This feature article highlights the development of additions to ketimines catalyzed by these three metals, that is, (i) Pd(ii)-catalyzed enantioselective additions of arylboronic acids to ketimines, (ii) Ni(ii)-catalyzed enantioselective additions of arylboronic and alkenylboronic acids to ketimines, and (iii) Co(ii)-catalyzed enantioselective additions of potassium allyltrifluoroborate to ketimines.	arylboronic	167-178	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	200-202
30066702-4	2018	This feature article highlights the development of additions to ketimines catalyzed by these three metals, that is, (i) Pd(ii)-catalyzed enantioselective additions of arylboronic acids to ketimines, (ii) Ni(ii)-catalyzed enantioselective additions of arylboronic and alkenylboronic acids to ketimines, and (iii) Co(ii)-catalyzed enantioselective additions of potassium allyltrifluoroborate to ketimines.	arylboronic	167-178	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	312-317
30066702-4	2018	This feature article highlights the development of additions to ketimines catalyzed by these three metals, that is, (i) Pd(ii)-catalyzed enantioselective additions of arylboronic acids to ketimines, (ii) Ni(ii)-catalyzed enantioselective additions of arylboronic and alkenylboronic acids to ketimines, and (iii) Co(ii)-catalyzed enantioselective additions of potassium allyltrifluoroborate to ketimines.	alkenylboronic acids	267-287	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-125
30066702-4	2018	This feature article highlights the development of additions to ketimines catalyzed by these three metals, that is, (i) Pd(ii)-catalyzed enantioselective additions of arylboronic acids to ketimines, (ii) Ni(ii)-catalyzed enantioselective additions of arylboronic and alkenylboronic acids to ketimines, and (iii) Co(ii)-catalyzed enantioselective additions of potassium allyltrifluoroborate to ketimines.	alkenylboronic acids	267-287	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	200-202
30066702-4	2018	This feature article highlights the development of additions to ketimines catalyzed by these three metals, that is, (i) Pd(ii)-catalyzed enantioselective additions of arylboronic acids to ketimines, (ii) Ni(ii)-catalyzed enantioselective additions of arylboronic and alkenylboronic acids to ketimines, and (iii) Co(ii)-catalyzed enantioselective additions of potassium allyltrifluoroborate to ketimines.	alkenylboronic acids	267-287	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	200-202
30066702-4	2018	This feature article highlights the development of additions to ketimines catalyzed by these three metals, that is, (i) Pd(ii)-catalyzed enantioselective additions of arylboronic acids to ketimines, (ii) Ni(ii)-catalyzed enantioselective additions of arylboronic and alkenylboronic acids to ketimines, and (iii) Co(ii)-catalyzed enantioselective additions of potassium allyltrifluoroborate to ketimines.	ketimine	188-197	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-125
30066702-4	2018	This feature article highlights the development of additions to ketimines catalyzed by these three metals, that is, (i) Pd(ii)-catalyzed enantioselective additions of arylboronic acids to ketimines, (ii) Ni(ii)-catalyzed enantioselective additions of arylboronic and alkenylboronic acids to ketimines, and (iii) Co(ii)-catalyzed enantioselective additions of potassium allyltrifluoroborate to ketimines.	ketimine	188-197	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	312-317
30066702-4	2018	This feature article highlights the development of additions to ketimines catalyzed by these three metals, that is, (i) Pd(ii)-catalyzed enantioselective additions of arylboronic acids to ketimines, (ii) Ni(ii)-catalyzed enantioselective additions of arylboronic and alkenylboronic acids to ketimines, and (iii) Co(ii)-catalyzed enantioselective additions of potassium allyltrifluoroborate to ketimines.	Potassium allyltrifluoroborate	359-389	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-125
30066702-4	2018	This feature article highlights the development of additions to ketimines catalyzed by these three metals, that is, (i) Pd(ii)-catalyzed enantioselective additions of arylboronic acids to ketimines, (ii) Ni(ii)-catalyzed enantioselective additions of arylboronic and alkenylboronic acids to ketimines, and (iii) Co(ii)-catalyzed enantioselective additions of potassium allyltrifluoroborate to ketimines.	Potassium allyltrifluoroborate	359-389	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	200-202
30066702-4	2018	This feature article highlights the development of additions to ketimines catalyzed by these three metals, that is, (i) Pd(ii)-catalyzed enantioselective additions of arylboronic acids to ketimines, (ii) Ni(ii)-catalyzed enantioselective additions of arylboronic and alkenylboronic acids to ketimines, and (iii) Co(ii)-catalyzed enantioselective additions of potassium allyltrifluoroborate to ketimines.	Potassium allyltrifluoroborate	359-389	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	200-202
30066702-4	2018	This feature article highlights the development of additions to ketimines catalyzed by these three metals, that is, (i) Pd(ii)-catalyzed enantioselective additions of arylboronic acids to ketimines, (ii) Ni(ii)-catalyzed enantioselective additions of arylboronic and alkenylboronic acids to ketimines, and (iii) Co(ii)-catalyzed enantioselective additions of potassium allyltrifluoroborate to ketimines.	ketimine	188-197	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-125
30066702-4	2018	This feature article highlights the development of additions to ketimines catalyzed by these three metals, that is, (i) Pd(ii)-catalyzed enantioselective additions of arylboronic acids to ketimines, (ii) Ni(ii)-catalyzed enantioselective additions of arylboronic and alkenylboronic acids to ketimines, and (iii) Co(ii)-catalyzed enantioselective additions of potassium allyltrifluoroborate to ketimines.	ketimine	188-197	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	312-317
30227633-2	2018	Here we show that an i-motif DNA sequence may transition to a base-extruded duplex structure with a GGCC tetranucleotide tract when bound to the (CoII)-mediated dimer of chromomycin A3, CoII(Chro)2.	tetranucleotide	105-120	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	146-150
30227633-2	2018	Here we show that an i-motif DNA sequence may transition to a base-extruded duplex structure with a GGCC tetranucleotide tract when bound to the (CoII)-mediated dimer of chromomycin A3, CoII(Chro)2.	tetranucleotide	105-120	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	186-190
30227633-2	2018	Here we show that an i-motif DNA sequence may transition to a base-extruded duplex structure with a GGCC tetranucleotide tract when bound to the (CoII)-mediated dimer of chromomycin A3, CoII(Chro)2.	Chromomycin A3	170-184	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	146-150
30227633-3	2018	Biophysical experiments reveal that CCG trinucleotide repeats provide favorable binding sites for CoII(Chro)2.	trinucleotide	40-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-109
30227633-4	2018	In addition, water hydration and divalent metal ion (CoII) interactions also play a crucial role in the stabilization of CCG trinucleotide repeats (TNRs).	Metals	42-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-57
30227633-4	2018	In addition, water hydration and divalent metal ion (CoII) interactions also play a crucial role in the stabilization of CCG trinucleotide repeats (TNRs).	trinucleotide	125-138	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-57
29727852-6	2018	For instance, it contributed 26% of the total SMZ transformation, while SO4- contributed the other 74% during the removal of SMZ, in Co(II)/PMS oxidation process with initial PMS and Co(II) concentrations of 1.0 mM and 0.1 muM, respectively.	Sulfamethazine	125-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	133-139
29727852-6	2018	For instance, it contributed 26% of the total SMZ transformation, while SO4- contributed the other 74% during the removal of SMZ, in Co(II)/PMS oxidation process with initial PMS and Co(II) concentrations of 1.0 mM and 0.1 muM, respectively.	Sulfamethazine	125-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	183-189
30066702-0	2018	Pd(ii), Ni(ii) and Co(ii)-catalyzed enantioselective additions of organoboron reagents to ketimines.	organoboron	66-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	3-5
30066702-0	2018	Pd(ii), Ni(ii) and Co(ii)-catalyzed enantioselective additions of organoboron reagents to ketimines.	organoboron	66-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-13
30066702-0	2018	Pd(ii), Ni(ii) and Co(ii)-catalyzed enantioselective additions of organoboron reagents to ketimines.	organoboron	66-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-24
30066702-0	2018	Pd(ii), Ni(ii) and Co(ii)-catalyzed enantioselective additions of organoboron reagents to ketimines.	ketimine	90-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	3-5
30066702-0	2018	Pd(ii), Ni(ii) and Co(ii)-catalyzed enantioselective additions of organoboron reagents to ketimines.	ketimine	90-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-13
30066702-0	2018	Pd(ii), Ni(ii) and Co(ii)-catalyzed enantioselective additions of organoboron reagents to ketimines.	ketimine	90-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-24
30066702-3	2018	Recently, significant advances have emerged in Pd(ii), Ni(ii), and Co(ii)-catalyzed asymmetric additions of organoboron reagents.	organoboron reagents	108-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-52
30066702-3	2018	Recently, significant advances have emerged in Pd(ii), Ni(ii), and Co(ii)-catalyzed asymmetric additions of organoboron reagents.	organoboron reagents	108-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-60
30066702-3	2018	Recently, significant advances have emerged in Pd(ii), Ni(ii), and Co(ii)-catalyzed asymmetric additions of organoboron reagents.	organoboron reagents	108-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-72
30066702-4	2018	This feature article highlights the development of additions to ketimines catalyzed by these three metals, that is, (i) Pd(ii)-catalyzed enantioselective additions of arylboronic acids to ketimines, (ii) Ni(ii)-catalyzed enantioselective additions of arylboronic and alkenylboronic acids to ketimines, and (iii) Co(ii)-catalyzed enantioselective additions of potassium allyltrifluoroborate to ketimines.	ketimine	64-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-125
30066702-4	2018	This feature article highlights the development of additions to ketimines catalyzed by these three metals, that is, (i) Pd(ii)-catalyzed enantioselective additions of arylboronic acids to ketimines, (ii) Ni(ii)-catalyzed enantioselective additions of arylboronic and alkenylboronic acids to ketimines, and (iii) Co(ii)-catalyzed enantioselective additions of potassium allyltrifluoroborate to ketimines.	ketimine	64-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	200-202
30066702-4	2018	This feature article highlights the development of additions to ketimines catalyzed by these three metals, that is, (i) Pd(ii)-catalyzed enantioselective additions of arylboronic acids to ketimines, (ii) Ni(ii)-catalyzed enantioselective additions of arylboronic and alkenylboronic acids to ketimines, and (iii) Co(ii)-catalyzed enantioselective additions of potassium allyltrifluoroborate to ketimines.	ketimine	64-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	200-202
30066702-4	2018	This feature article highlights the development of additions to ketimines catalyzed by these three metals, that is, (i) Pd(ii)-catalyzed enantioselective additions of arylboronic acids to ketimines, (ii) Ni(ii)-catalyzed enantioselective additions of arylboronic and alkenylboronic acids to ketimines, and (iii) Co(ii)-catalyzed enantioselective additions of potassium allyltrifluoroborate to ketimines.	ketimine	64-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	312-317
30066702-4	2018	This feature article highlights the development of additions to ketimines catalyzed by these three metals, that is, (i) Pd(ii)-catalyzed enantioselective additions of arylboronic acids to ketimines, (ii) Ni(ii)-catalyzed enantioselective additions of arylboronic and alkenylboronic acids to ketimines, and (iii) Co(ii)-catalyzed enantioselective additions of potassium allyltrifluoroborate to ketimines.	arylboronic acids	167-184	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-125
30066702-4	2018	This feature article highlights the development of additions to ketimines catalyzed by these three metals, that is, (i) Pd(ii)-catalyzed enantioselective additions of arylboronic acids to ketimines, (ii) Ni(ii)-catalyzed enantioselective additions of arylboronic and alkenylboronic acids to ketimines, and (iii) Co(ii)-catalyzed enantioselective additions of potassium allyltrifluoroborate to ketimines.	arylboronic acids	167-184	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	200-202
30066702-4	2018	This feature article highlights the development of additions to ketimines catalyzed by these three metals, that is, (i) Pd(ii)-catalyzed enantioselective additions of arylboronic acids to ketimines, (ii) Ni(ii)-catalyzed enantioselective additions of arylboronic and alkenylboronic acids to ketimines, and (iii) Co(ii)-catalyzed enantioselective additions of potassium allyltrifluoroborate to ketimines.	arylboronic acids	167-184	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	200-202
30217008-1	2018	In this study, the adsorption behavior of CaAl-Cl layered double hydroxide (CaAl-Cl-LDH) with a controlled pH value (pH = 6) on Co(II) ions ([Co] = 8 mM) is investigated.	caal-cl	42-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	128-134
30217008-1	2018	In this study, the adsorption behavior of CaAl-Cl layered double hydroxide (CaAl-Cl-LDH) with a controlled pH value (pH = 6) on Co(II) ions ([Co] = 8 mM) is investigated.	double	58-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	128-134
30217008-1	2018	In this study, the adsorption behavior of CaAl-Cl layered double hydroxide (CaAl-Cl-LDH) with a controlled pH value (pH = 6) on Co(II) ions ([Co] = 8 mM) is investigated.	hydroxide ion	65-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	128-134
30217008-1	2018	In this study, the adsorption behavior of CaAl-Cl layered double hydroxide (CaAl-Cl-LDH) with a controlled pH value (pH = 6) on Co(II) ions ([Co] = 8 mM) is investigated.	caal-cl-ldh	76-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	128-134
30217008-4	2018	To shed light on the adsorption products and the mechanisms in the adsorption process of Co(II) in an aqueous solution by CaAl-Cl-LDH, a series of testing methods including Fourier-transform infrared spectroscopy (FT-IR), Scanning electron microscope (SEM), High-resolution transmission electron microscopy (HR-TEM), X-ray photoelectron spectroscopy (XPS), and inductively coupled plasma (ICP) are applied to clarify the interaction between cobalt and CaAl-Cl-LDH.	caal-cl	122-129	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-95
30217008-6	2018	The crystalline phases are identified as Co6Al2CO3(OH)16 4H2O, which is attributed to the co-precipitation process occurring in the interaction between Co(II) and CaAl-Cl-LDH.	co6al2co3(oh)16 4h2o	41-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-158
30217008-6	2018	The crystalline phases are identified as Co6Al2CO3(OH)16 4H2O, which is attributed to the co-precipitation process occurring in the interaction between Co(II) and CaAl-Cl-LDH.	caal-cl	163-170	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-158
30568777-0	2018	Merohedral icosahedral M48 (M = CoII, NiII) cage clusters supported by thiacalix[4]arene.	thiacalix	71-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-36
30568777-0	2018	Merohedral icosahedral M48 (M = CoII, NiII) cage clusters supported by thiacalix[4]arene.	arene	83-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-36
30124288-0	2018	Additive-Induced Supramolecular Isomerism and Enhancement of Robustness in Co(II)-Based MOFs for Efficiently Trapping Acetylene from Acetylene-Containing Mixtures.	Acetylene	133-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
29969649-0	2018	Meroterpenoid dimers from Ganoderma cochlear and their cytotoxic and COX-2 inhibitory activities.	meroterpenoid	0-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-74
30205620-8	2018	In vitro, PCS promotes alveolar cell death, cPLA2/COX-2/aquaporin-4 expression, and NADPH oxidase/mitochondria activation-related ROS.	4-cresol sulfate	10-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-55
30111101-6	2018	Metal chelates of CH3C(O)NHOH catalyze the hydrolysis of CH3C(O)N O at the efficacy order of CuII &gt; ZnII &gt; NiII &gt; CoII where only CuII catalyzes the hydrolysis also in the absence of the hydroxamate.	Metals	0-5	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-127
30111101-6	2018	Metal chelates of CH3C(O)NHOH catalyze the hydrolysis of CH3C(O)N O at the efficacy order of CuII &gt; ZnII &gt; NiII &gt; CoII where only CuII catalyzes the hydrolysis also in the absence of the hydroxamate.	nhoh	25-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-127
30111101-6	2018	Metal chelates of CH3C(O)NHOH catalyze the hydrolysis of CH3C(O)N O at the efficacy order of CuII &gt; ZnII &gt; NiII &gt; CoII where only CuII catalyzes the hydrolysis also in the absence of the hydroxamate.	hydroxamate	196-207	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-127
30149323-0	2018	Design, synthesis and biological evaluation of novel ferrocene-pyrazole derivatives containing nitric oxide donors as COX-2 inhibitors for cancer therapy.	Nitric Oxide	95-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-123
30149323-1	2018	A series of novel ferrocene-pyrazole derivatives containing nitric oxide donors as COX-2 inhibitors for cancer therapy were designed, synthesized and biologically evaluated.	ferrocene-pyrazole	18-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
30149323-1	2018	A series of novel ferrocene-pyrazole derivatives containing nitric oxide donors as COX-2 inhibitors for cancer therapy were designed, synthesized and biologically evaluated.	Nitric Oxide	60-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
30254666-5	2018	The ability of 2 to become reduced in the presence of ascorbic acid was probed demonstrating the likely reduction of the Co(III) metal center to Co(II).	Ascorbic Acid	54-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-151
30094570-3	2018	Accumulating evidence indicates that the COX2/PGE2/EP axis plays crucial roles not only in tumor development including initiation and progression but also in the development of therapeutic resistance.	Dinoprostone	46-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-45
30094570-4	2018	In this review, we will first dissect the relationship between the COX2/PGE2/EP axis and therapeutic resistance by focusing on the roles of the COX2/PGE2/EP axis in cancer stem cell repopulation, EMT, and anti-cancer immunity.	Dinoprostone	72-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-71
30019133-0	2018	Performance of ceria/iron oxide nano-composites based on chitosan as an effective adsorbent for removal of Cr(VI) and Co(II) ions from aqueous systems.	ceric oxide	15-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-124
30019133-0	2018	Performance of ceria/iron oxide nano-composites based on chitosan as an effective adsorbent for removal of Cr(VI) and Co(II) ions from aqueous systems.	ferric oxide	21-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-124
30019133-1	2018	A novel chitosan/ceria/iron oxide (CS/ceria/Fe3O4) nano-composite adsorbent was synthesized for removal of Cr(VI) and Co(II) ions from aqueous systems in a batch system.	Chitosan	8-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-124
30019133-1	2018	A novel chitosan/ceria/iron oxide (CS/ceria/Fe3O4) nano-composite adsorbent was synthesized for removal of Cr(VI) and Co(II) ions from aqueous systems in a batch system.	ceric oxide	17-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-124
30019133-1	2018	A novel chitosan/ceria/iron oxide (CS/ceria/Fe3O4) nano-composite adsorbent was synthesized for removal of Cr(VI) and Co(II) ions from aqueous systems in a batch system.	ferric oxide	23-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-124
30019133-1	2018	A novel chitosan/ceria/iron oxide (CS/ceria/Fe3O4) nano-composite adsorbent was synthesized for removal of Cr(VI) and Co(II) ions from aqueous systems in a batch system.	Cesium	35-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-124
30019133-1	2018	A novel chitosan/ceria/iron oxide (CS/ceria/Fe3O4) nano-composite adsorbent was synthesized for removal of Cr(VI) and Co(II) ions from aqueous systems in a batch system.	ceric oxide	38-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-124
30019133-1	2018	A novel chitosan/ceria/iron oxide (CS/ceria/Fe3O4) nano-composite adsorbent was synthesized for removal of Cr(VI) and Co(II) ions from aqueous systems in a batch system.	ferryl iron	44-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-124
30019133-10	2018	Finally, the evaluation of Cr(VI)-Co(II) coexisting system confirmed that the presence of Co(II) ions played an inhibitor role on the Cr(VI) adsorption.	chromium hexavalent ion	27-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-40
30019133-10	2018	Finally, the evaluation of Cr(VI)-Co(II) coexisting system confirmed that the presence of Co(II) ions played an inhibitor role on the Cr(VI) adsorption.	chromium hexavalent ion	27-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-96
30019133-10	2018	Finally, the evaluation of Cr(VI)-Co(II) coexisting system confirmed that the presence of Co(II) ions played an inhibitor role on the Cr(VI) adsorption.	chromium hexavalent ion	134-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-40
30019133-10	2018	Finally, the evaluation of Cr(VI)-Co(II) coexisting system confirmed that the presence of Co(II) ions played an inhibitor role on the Cr(VI) adsorption.	chromium hexavalent ion	134-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-96
30152699-0	2018	Co(II)/Ag(I) Synergistically Catalyzed Monoinsertion Reaction of Isocyanide to Terminal Alkynes with H2O: Synthesis of Alkynamide Derivatives.	Cyanides	65-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
30152699-0	2018	Co(II)/Ag(I) Synergistically Catalyzed Monoinsertion Reaction of Isocyanide to Terminal Alkynes with H2O: Synthesis of Alkynamide Derivatives.	Alkynes	88-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
30152699-0	2018	Co(II)/Ag(I) Synergistically Catalyzed Monoinsertion Reaction of Isocyanide to Terminal Alkynes with H2O: Synthesis of Alkynamide Derivatives.	Water	101-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
30152699-0	2018	Co(II)/Ag(I) Synergistically Catalyzed Monoinsertion Reaction of Isocyanide to Terminal Alkynes with H2O: Synthesis of Alkynamide Derivatives.	alkynamide	119-129	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
30152699-1	2018	A Co(II)/Ag(I) synergistically catalyzed three-component reaction of isocyanide with terminal alkyne and water to afford alkynamide derivatives is reported.	Cyanides	69-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	2-8
30152699-1	2018	A Co(II)/Ag(I) synergistically catalyzed three-component reaction of isocyanide with terminal alkyne and water to afford alkynamide derivatives is reported.	Alkynes	94-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	2-8
30152699-1	2018	A Co(II)/Ag(I) synergistically catalyzed three-component reaction of isocyanide with terminal alkyne and water to afford alkynamide derivatives is reported.	Water	105-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	2-8
30152699-1	2018	A Co(II)/Ag(I) synergistically catalyzed three-component reaction of isocyanide with terminal alkyne and water to afford alkynamide derivatives is reported.	alkynamide	121-131	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	2-8
30152699-3	2018	This synergistic process achieves the cleavage of a C-H bond and the construction of new C-C and C O bonds under mild conditions through the reaction of Co(II)-activated isocyanides and a Ag(I)-complex-activated terminal alkyne.	Cyanides	170-181	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	153-158
30152699-3	2018	This synergistic process achieves the cleavage of a C-H bond and the construction of new C-C and C O bonds under mild conditions through the reaction of Co(II)-activated isocyanides and a Ag(I)-complex-activated terminal alkyne.	Alkynes	221-227	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	153-158
30149323-0	2018	Design, synthesis and biological evaluation of novel ferrocene-pyrazole derivatives containing nitric oxide donors as COX-2 inhibitors for cancer therapy.	ferrocene-pyrazole	53-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-123
30180847-8	2018	Furthermore, time-course analysis of COX-2 expression revealed earlier increases in SAECs compared with NHBEs following CS exposure.	Cesium	120-122	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-42
29858743-6	2018	We show that cyclooxygenase (COX)-2 expression by breast cancer cells or tumor stroma leading to high PGE2 levels in the tumor milieu promotes lymphangiogenesis and lymphatic metastases, resulting from binding of PGE2 to PGE receptors (EP, in particular EP4) on multiple cell types: tumor cells, tumor-infiltrating immune cells, and LEC.	Dinoprostone	102-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-35
29858743-6	2018	We show that cyclooxygenase (COX)-2 expression by breast cancer cells or tumor stroma leading to high PGE2 levels in the tumor milieu promotes lymphangiogenesis and lymphatic metastases, resulting from binding of PGE2 to PGE receptors (EP, in particular EP4) on multiple cell types: tumor cells, tumor-infiltrating immune cells, and LEC.	Dinoprostone	213-217	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-35
29726034-0	2018	Flavonoids from Boldoa purpurascens inhibit proinflammatory cytokines (TNF-alpha and IL-6) and the expression of COX-2.	Flavonoids	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-118
30570856-6	2018	Celecoxib, a COX-2 selective inhibitor, was used to inhibit the COX-2 of HC8693 cells, and the inhibiting effect of TSIIA on HC8693 cell growth was assessed.	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
30570856-6	2018	Celecoxib, a COX-2 selective inhibitor, was used to inhibit the COX-2 of HC8693 cells, and the inhibiting effect of TSIIA on HC8693 cell growth was assessed.	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-69
29427085-5	2018	Among the tested neuroinflammation, epigallocatechin gallate (EGCG) and minocycline exerted BDNF upregulation to inhibit COX-2 and proinflammatory mediator expressions.	epigallocatechin gallate	36-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-126
29427085-5	2018	Among the tested neuroinflammation, epigallocatechin gallate (EGCG) and minocycline exerted BDNF upregulation to inhibit COX-2 and proinflammatory mediator expressions.	epigallocatechin gallate	62-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-126
29427085-5	2018	Among the tested neuroinflammation, epigallocatechin gallate (EGCG) and minocycline exerted BDNF upregulation to inhibit COX-2 and proinflammatory mediator expressions.	Minocycline	72-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-126
30015902-5	2018	Pretreatment with spilanthol decreased TNF-alpha-induced COX-2 expression by western blotting and suppressed the expression of pro-inflammatory mediators, including interleukin (IL)-6, IL-8 and monocyte chemotactic protein 1 using ELISA.	N-isobutyl-2E-decenamide	18-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-62
30015902-8	2018	These results demonstrated that spilanthol may exert its anti-inflammatory activity by suppressing the TNF-alpha-induced expression of ICAM-1, COX-2 and pro-inflammatory mediators by enhancing that of HO-1, and inhibiting the activation of the phosphorylated JNK signaling pathway.	N-isobutyl-2E-decenamide	32-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	143-148
30127998-8	2018	The AhR antagonist CH-223191, blocks the effects on TCDD-induced RANKL, COX-2, PGE2 and CXCR4 changes.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	19-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
30127998-8	2018	The AhR antagonist CH-223191, blocks the effects on TCDD-induced RANKL, COX-2, PGE2 and CXCR4 changes.	Polychlorinated Dibenzodioxins	52-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
30043217-10	2018	Moreover, cantharidin reduced cell proliferation and induced apoptosis with downregulation of STAT3 target genes, such as Bcl-2, COX-2, and cyclin D1.	Cantharidin	10-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-134
29978868-1	2018	Helical peptoids bearing 2,2"-bipyridine, varied in their chiral bulky side chains and their N-terminus form complexes with Cu(ii), Co(ii) and Ni(ii) via intramolecular binding.	2,2'-Dipyridyl	25-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-138
30028133-2	2018	We previously identified by in silico screening naproxen being a dual inhibitor of NP and cyclooxygenase COX2, thus combining antiviral and anti-inflammatory effects.	Naproxen	48-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-109
30135355-5	2018	Apoptosis occurred and the EGCG+IIF treatment decreased N-MYC protein expression and molecular markers of invasion (MMP-2, MMP-9 and COX-2).	epigallocatechin gallate	27-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	133-138
29978868-1	2018	Helical peptoids bearing 2,2"-bipyridine, varied in their chiral bulky side chains and their N-terminus form complexes with Cu(ii), Co(ii) and Ni(ii) via intramolecular binding.	2,2'-Dipyridyl	25-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-137
30043034-1	2018	The bis(di-tert-butyl-aminophenyl)amine ligand H3LN,N,N was reacted with Mn(ii), Co(ii), Fe(iii) and Cu(ii) salts in air.	bis(di-tert-butyl-aminophenyl)amine	4-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-78
30043034-1	2018	The bis(di-tert-butyl-aminophenyl)amine ligand H3LN,N,N was reacted with Mn(ii), Co(ii), Fe(iii) and Cu(ii) salts in air.	bis(di-tert-butyl-aminophenyl)amine	4-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-87
29978868-0	2018	Chiral Cu(ii), Co(ii) and Ni(ii) complexes based on 2,2"-bipyridine modified peptoids.	2,2'-Dipyridyl	52-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-12
29978868-0	2018	Chiral Cu(ii), Co(ii) and Ni(ii) complexes based on 2,2"-bipyridine modified peptoids.	2,2'-Dipyridyl	52-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-21
29885333-4	2018	Through ROS generation, cadmium increased the protein level of TNF-alpha, which activated NF-kappaB and its target protein COX-2, creating an inflammatory microenvironment.	Reactive Oxygen Species	8-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-128
29978868-0	2018	Chiral Cu(ii), Co(ii) and Ni(ii) complexes based on 2,2"-bipyridine modified peptoids.	2,2'-Dipyridyl	52-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-20
29978868-1	2018	Helical peptoids bearing 2,2"-bipyridine, varied in their chiral bulky side chains and their N-terminus form complexes with Cu(ii), Co(ii) and Ni(ii) via intramolecular binding.	2,2'-Dipyridyl	25-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	127-129
30094992-2	2018	More interestingly, under the same condition, the assembly of 4-methyl-3,5-di(pyridin-4-yl) benzoic acid (HMDPB) with Co(II) facilitates the formation of a cationic framework, [Co2(MDPB)3(DMF)](NO3)  xS (2), with cobalt dimer, [Co2(CO2)3N4], as building blocks.	4-methyl-3,5-di(pyridin-4-yl) benzoic acid	62-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-124
30094992-2	2018	More interestingly, under the same condition, the assembly of 4-methyl-3,5-di(pyridin-4-yl) benzoic acid (HMDPB) with Co(II) facilitates the formation of a cationic framework, [Co2(MDPB)3(DMF)](NO3)  xS (2), with cobalt dimer, [Co2(CO2)3N4], as building blocks.	hmdpb	106-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-124
30094992-2	2018	More interestingly, under the same condition, the assembly of 4-methyl-3,5-di(pyridin-4-yl) benzoic acid (HMDPB) with Co(II) facilitates the formation of a cationic framework, [Co2(MDPB)3(DMF)](NO3)  xS (2), with cobalt dimer, [Co2(CO2)3N4], as building blocks.	co2(mdpb)3(dmf)	177-192	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-124
30094992-2	2018	More interestingly, under the same condition, the assembly of 4-methyl-3,5-di(pyridin-4-yl) benzoic acid (HMDPB) with Co(II) facilitates the formation of a cationic framework, [Co2(MDPB)3(DMF)](NO3)  xS (2), with cobalt dimer, [Co2(CO2)3N4], as building blocks.	no3)  xs	194-202	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-124
30094992-2	2018	More interestingly, under the same condition, the assembly of 4-methyl-3,5-di(pyridin-4-yl) benzoic acid (HMDPB) with Co(II) facilitates the formation of a cationic framework, [Co2(MDPB)3(DMF)](NO3)  xS (2), with cobalt dimer, [Co2(CO2)3N4], as building blocks.	Cobalt	213-219	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-124
30094992-2	2018	More interestingly, under the same condition, the assembly of 4-methyl-3,5-di(pyridin-4-yl) benzoic acid (HMDPB) with Co(II) facilitates the formation of a cationic framework, [Co2(MDPB)3(DMF)](NO3)  xS (2), with cobalt dimer, [Co2(CO2)3N4], as building blocks.	co2(	177-181	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-124
30094992-2	2018	More interestingly, under the same condition, the assembly of 4-methyl-3,5-di(pyridin-4-yl) benzoic acid (HMDPB) with Co(II) facilitates the formation of a cationic framework, [Co2(MDPB)3(DMF)](NO3)  xS (2), with cobalt dimer, [Co2(CO2)3N4], as building blocks.	co2)3n4	232-239	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-124
30066004-5	2018	Chronic arsenite exposure also led to an upregulation of proliferation factors such as cyclin D1, COX2, PCNA, VEGF, and HIF-1alpha.	arsenite	8-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-102
29885333-4	2018	Through ROS generation, cadmium increased the protein level of TNF-alpha, which activated NF-kappaB and its target protein COX-2, creating an inflammatory microenvironment.	Cadmium	24-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-128
30043034-1	2018	The bis(di-tert-butyl-aminophenyl)amine ligand H3LN,N,N was reacted with Mn(ii), Co(ii), Fe(iii) and Cu(ii) salts in air.	bis(di-tert-butyl-aminophenyl)amine	4-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-86
30043034-1	2018	The bis(di-tert-butyl-aminophenyl)amine ligand H3LN,N,N was reacted with Mn(ii), Co(ii), Fe(iii) and Cu(ii) salts in air.	h3ln	47-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-78
30043034-1	2018	The bis(di-tert-butyl-aminophenyl)amine ligand H3LN,N,N was reacted with Mn(ii), Co(ii), Fe(iii) and Cu(ii) salts in air.	h3ln	47-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-87
30043034-1	2018	The bis(di-tert-butyl-aminophenyl)amine ligand H3LN,N,N was reacted with Mn(ii), Co(ii), Fe(iii) and Cu(ii) salts in air.	h3ln	47-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-86
30960859-0	2018	Influences of Fluorine Substituents on Iminopyridine Fe(II)- and Co(II)-Catalyzed Isoprene Polymerization.	Fluorine	14-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-71
30960859-0	2018	Influences of Fluorine Substituents on Iminopyridine Fe(II)- and Co(II)-Catalyzed Isoprene Polymerization.	isoprene	82-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-71
30960859-1	2018	A series of iminopyridine complexes of Fe(II) and Co(II) complexes bearing fluorinated aryl substituents were synthesized for the polymerization of isoprene.	Aminopyridines	12-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-56
30960859-1	2018	A series of iminopyridine complexes of Fe(II) and Co(II) complexes bearing fluorinated aryl substituents were synthesized for the polymerization of isoprene.	isoprene	148-156	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-56
30960859-4	2018	Complexes 2b and 3b represented rare examples of chlorine bridged bimetallic Co(II) complexes.	Chlorine	49-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-83
30960859-9	2018	In the series of Co(II)/AlEt2Cl binary systems, complexes containing electron-withdrawing N-aryl substituents (R = 4-CF3, 2,6-2F) afforded higher molecular weights polyisoprene than that was obtained by the complex containing electron-donating N-alkyl substituents (R = octyl).	Nitrogen	90-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-23
30960859-9	2018	In the series of Co(II)/AlEt2Cl binary systems, complexes containing electron-withdrawing N-aryl substituents (R = 4-CF3, 2,6-2F) afforded higher molecular weights polyisoprene than that was obtained by the complex containing electron-donating N-alkyl substituents (R = octyl).	alkyl	246-251	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-23
30031652-0	2018	Design and biological evaluation of novel hybrids of 1, 5-diarylpyrazole and Chrysin for selective COX-2 inhibition.	1, 5-diarylpyrazole	53-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-104
30103745-12	2018	CONCLUSIONS: Our results indicated that SPS may inhibit TSCC development through regulation of Bcl-2, COX-2, Bax, and cleaved caspase-3 expression.	Sodium phenolsulfonate	40-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-107
30103745-4	2018	After treatment with 5 mug/mL cisplatin and 0.64 mg/mL SPS, the induction of apoptosis and the protein and mRNA expression of Bax, Bcl-2, COX-2, and cleaved caspase-3 in HN-6 cells were quantified.	Cisplatin	30-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	138-143
30103745-10	2018	Compared with the control group, the expression of Bcl-2 and COX-2 was markedly reduced by SPS treatment, whereas the expression of Bax and cleaved caspase-3 was increased.	Sodium phenolsulfonate	91-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-66
30103745-11	2018	Moreover, SPS significantly inhibited the growth of the tumor xenograft, with similar changes in the expression of Bcl-2, COX-2, Bax, and cleaved caspase-3 in the tumor xenograft to the in vitro analysis.	Sodium phenolsulfonate	10-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-127
29980364-1	2018	A novel group of aryl methyl sulfones based on nonsteroidal anti-inflammatory compounds exhibiting a methyl sulfone instead of the acetic or propionic acid group was designed, synthesized and evaluated in vitro for inhibition against the human cyclooxygenase of COX-1 and COX-2 isoenzymes and in vivo for anti-inflammatory activity using the carrageenan induced rat paw edema model in rats.	aryl methyl sulfones	17-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	272-277
30031652-0	2018	Design and biological evaluation of novel hybrids of 1, 5-diarylpyrazole and Chrysin for selective COX-2 inhibition.	chrysin	77-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-104
29884023-2	2018	In addition, iodocyclization of fluorinated propargylamine affords chiral 3-iodo-2-(trifluoromethyl)-1,2-dihydroquinoline, which can be easily converted to 2-(trifluoromethyl)- 1,2-dihydroquinoline derivatives with the selective COX-2 inhibitory activity.	propargylamine	44-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	229-234
30042991-2	2018	The CoII ion possesses an ideal trigonal antiprismatic geometry because of the intermolecular hydrogen-bonds between the metalloligands via counter anions.	Hydrogen	94-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-8
30131758-2	2018	Cyclooxygenase (COX)-2 inhibitor celecoxib is used for the treatment of acute pain due to its potent anti-inflammatory and analgesic effects.	Celecoxib	33-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-22
31459006-4	2018	The functionalized MPM (F-MPM) had polar triazole groups generated by the click reaction, which were used as coordination sites for Co(II) ions.	Triazoles	41-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-138
31459006-5	2018	Cobalt nanoparticles were loaded to F-MPM through in situ reduction of coordinated Co(II) ions to produce a monolithic Co heterogeneous catalyst (Co-MPM).	Cobalt	0-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-89
29884023-2	2018	In addition, iodocyclization of fluorinated propargylamine affords chiral 3-iodo-2-(trifluoromethyl)-1,2-dihydroquinoline, which can be easily converted to 2-(trifluoromethyl)- 1,2-dihydroquinoline derivatives with the selective COX-2 inhibitory activity.	OCID190080241538	74-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	229-234
30083389-7	2018	Furthermore, a strong correlation was found between pain relief observed in patients as well as celecoxib- and diclofenac-induced decrease in prostaglandins after 6 h. The findings presented reveal insights about drug-induced modulation of cellular networks in a whole-body context, thereby describing complex pharmacokinetic/pharmacodynamic behavior of COX-2 and 5-LOX inhibitors in therapeutic situations.	Celecoxib	96-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	354-365
30083389-7	2018	Furthermore, a strong correlation was found between pain relief observed in patients as well as celecoxib- and diclofenac-induced decrease in prostaglandins after 6 h. The findings presented reveal insights about drug-induced modulation of cellular networks in a whole-body context, thereby describing complex pharmacokinetic/pharmacodynamic behavior of COX-2 and 5-LOX inhibitors in therapeutic situations.	Diclofenac	111-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	354-365
30083389-7	2018	Furthermore, a strong correlation was found between pain relief observed in patients as well as celecoxib- and diclofenac-induced decrease in prostaglandins after 6 h. The findings presented reveal insights about drug-induced modulation of cellular networks in a whole-body context, thereby describing complex pharmacokinetic/pharmacodynamic behavior of COX-2 and 5-LOX inhibitors in therapeutic situations.	Prostaglandins	142-156	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	354-365
29884023-2	2018	In addition, iodocyclization of fluorinated propargylamine affords chiral 3-iodo-2-(trifluoromethyl)-1,2-dihydroquinoline, which can be easily converted to 2-(trifluoromethyl)- 1,2-dihydroquinoline derivatives with the selective COX-2 inhibitory activity.	2-(trifluoromethyl)- 1,2-dihydroquinoline	156-197	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	229-234
30068904-0	2018	Berberine ameliorates blockade of autophagic flux in the liver by regulating cholesterol metabolism and inhibiting COX2-prostaglandin synthesis.	Berberine	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-119
30080172-4	2018	The X-ray crystal structure of the cage, i.e. [Co4L6-ClO4](ClO4)7, shows that the substituted benzyl groups are oriented away from the centres of their respective ligands towards the CoII vertices, making small outward-facing pockets from three benzyl rings at the corners of the tetrahedron.	co4l6-clo4](clo4)7	47-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	183-187
29853604-4	2018	However, in contrast with SeV and poly I:C, rintatolimod did not activate the MAVS/helicase pathway, thus avoiding NFkappaB- and TNFalpha-dependent induction of COX2, COX2/PGE2-dependent induction of IDO, IL10, CCL22, and CXCL12, and eliminating Treg attraction.	poly(I).poly(c12,U)	44-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	161-165
29550530-0	2018	Design, synthesis, analgesic, anti-inflammatory activity of novel pyrazolones possessing aminosulfonyl pharmacophore as inhibitors of COX-2/5-LOX enzymes: Histopathological and docking studies.	Pyrazolones	66-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-139
29550530-0	2018	Design, synthesis, analgesic, anti-inflammatory activity of novel pyrazolones possessing aminosulfonyl pharmacophore as inhibitors of COX-2/5-LOX enzymes: Histopathological and docking studies.	aminosulfonyl	89-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-139
29550530-3	2018	Compounds 5d, 5f and 5i were found to be the most potent COX-2/5-LOX inhibitors with superior COX-2 selectivity index values (SI = 5.29-5.69) to reference standard celecoxib (SI = 3.52).	Celecoxib	164-173	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-62
29550533-1	2018	Three new series of 5-aminosalicylic acid derivatives; series I (14, 16-18), series II (19-30) and series III (31-41) were synthesized as potential dual COX-2/5-LOX inhibitors.	Mesalamine	20-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	153-158
29550533-6	2018	Compounds 34 &amp;35 exhibited significant COX-2 inhibition (IC50 = 0.10 microM) with significant COX-2 selectivity indices (SI = 135 &amp; 145 respectively) approximate to celecoxib (IC50 = 0.049 microM, SI = 308.16) and exceeding indomethacin (IC50 = 0.51 microM, SI = 0.08).	Adenosine Monophosphate	14-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
29550533-6	2018	Compounds 34 &amp;35 exhibited significant COX-2 inhibition (IC50 = 0.10 microM) with significant COX-2 selectivity indices (SI = 135 &amp; 145 respectively) approximate to celecoxib (IC50 = 0.049 microM, SI = 308.16) and exceeding indomethacin (IC50 = 0.51 microM, SI = 0.08).	Adenosine Monophosphate	14-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-103
29550533-6	2018	Compounds 34 &amp;35 exhibited significant COX-2 inhibition (IC50 = 0.10 microM) with significant COX-2 selectivity indices (SI = 135 &amp; 145 respectively) approximate to celecoxib (IC50 = 0.049 microM, SI = 308.16) and exceeding indomethacin (IC50 = 0.51 microM, SI = 0.08).	Celecoxib	173-182	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-103
29853604-4	2018	However, in contrast with SeV and poly I:C, rintatolimod did not activate the MAVS/helicase pathway, thus avoiding NFkappaB- and TNFalpha-dependent induction of COX2, COX2/PGE2-dependent induction of IDO, IL10, CCL22, and CXCL12, and eliminating Treg attraction.	poly(I).poly(c12,U)	44-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	167-171
29853604-5	2018	Induction of CTL-attractants by either poly I:C or rintatolimod was further enhanced by exogenous IFNalpha (enhancer of TLR3 expression), whereas COX2 inhibition enhanced the response to poly-I:C only.	Poly I-C	187-195	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	146-150
29802617-7	2018	The maximum removal capacities were 100.1 and 139.75 mg/g for Zn(II) and 57.93 and 112.1 mg/g for Co(II) using NPANI and NPANI-NAg2O, respectively.	nag2o	127-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-104
30203727-3	2018	Two groups of cobalt compounds are differentiated on the basis of their mechanisms of toxicity: (1) those essentially involving the solubilization of Co(II) ions, and (2) metallic materials for which both surface corrosion and release of Co(II) ions act in concert.	Cobalt	14-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	150-156
30203727-3	2018	Two groups of cobalt compounds are differentiated on the basis of their mechanisms of toxicity: (1) those essentially involving the solubilization of Co(II) ions, and (2) metallic materials for which both surface corrosion and release of Co(II) ions act in concert.	Cobalt	14-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	238-244
29913427-3	2018	Results showed that formononetin significantly reduced the production of TNF-alpha, IL-6 and IL-1beta, nitrite and PGE2, as well as protein levels of iNOS and COX-2.	formononetin	20-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	159-164
30154906-5	2018	The results showed that KJS018A significantly inhibited the proliferation of hepatic malignant cells and downregulated levels of IL-6 and Cox-2.	kjs018a	24-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	138-143
30154906-6	2018	Furthermore, KJS018A diminished the effect of PMA, an inflammatory inducer via IL-6/STAT3/Cox-2 pathway.	kjs018a	13-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-95
30154906-6	2018	Furthermore, KJS018A diminished the effect of PMA, an inflammatory inducer via IL-6/STAT3/Cox-2 pathway.	Tetradecanoylphorbol Acetate	46-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-95
29238904-3	2018	The test compounds fenofibric acid, fenofibrate, and the standard drug diclofenac exhibited binding energies of - 9.0, - 7.2, and - 8.0 kcal mol-1, respectively, against COX-2 and - 7.2, - 7.0, and - 6.5 kcal mol-1, respectively, against COX-1.	fenofibric acid	19-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	170-175
29238904-3	2018	The test compounds fenofibric acid, fenofibrate, and the standard drug diclofenac exhibited binding energies of - 9.0, - 7.2, and - 8.0 kcal mol-1, respectively, against COX-2 and - 7.2, - 7.0, and - 6.5 kcal mol-1, respectively, against COX-1.	Fenofibrate	36-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	170-175
29238904-3	2018	The test compounds fenofibric acid, fenofibrate, and the standard drug diclofenac exhibited binding energies of - 9.0, - 7.2, and - 8.0 kcal mol-1, respectively, against COX-2 and - 7.2, - 7.0, and - 6.5 kcal mol-1, respectively, against COX-1.	Diclofenac	71-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	170-175
29653357-0	2018	Controlling bromate formation in the Co(II)/peroxymonosulfate process by ammonia, chlorine-ammonia and ammonia-chlorine pretreatment strategies.	Bromates	12-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-43
29936228-2	2018	For this purpose, ZINC database was screened on the basis of 50% structural similarity with celecoxib and indomethacin as the representative of COX-2 and COX-1/COX-2 inhibitors, respectively.	Celecoxib	92-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	144-149
29936228-2	2018	For this purpose, ZINC database was screened on the basis of 50% structural similarity with celecoxib and indomethacin as the representative of COX-2 and COX-1/COX-2 inhibitors, respectively.	Celecoxib	92-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	160-165
29936228-2	2018	For this purpose, ZINC database was screened on the basis of 50% structural similarity with celecoxib and indomethacin as the representative of COX-2 and COX-1/COX-2 inhibitors, respectively.	Indomethacin	106-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	144-149
29936228-2	2018	For this purpose, ZINC database was screened on the basis of 50% structural similarity with celecoxib and indomethacin as the representative of COX-2 and COX-1/COX-2 inhibitors, respectively.	Indomethacin	106-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	160-165
29936228-8	2018	Furthermore, RMSD, RMSF, hydrogen binds, Rg and energy analysis during MD simulation certainly indicated the stable binding of selected compounds with COX-2 structure.	Hydrogen	25-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-156
29936228-9	2018	Moreover, docking and MD results revealed that hydrophobic contacts and optimum hydrogen bonds were determinant factors in the interactions of in silico hits and COX-2.	Hydrogen	80-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	162-167
32559940-2	2018	Almost complete dissolution of Li and nearly 90% dissolution of Co occurred in at 80  C for 6 h. The reducing agent, ascorbic acid (AA), converts the dissolved Co(III) to Co(II) thereby selective recovery of Co as Co(II)-oxalate is possible.	Cobalt	64-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	171-177
32559940-2	2018	Almost complete dissolution of Li and nearly 90% dissolution of Co occurred in at 80  C for 6 h. The reducing agent, ascorbic acid (AA), converts the dissolved Co(III) to Co(II) thereby selective recovery of Co as Co(II)-oxalate is possible.	Ascorbic Acid	117-130	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	171-177
32559940-2	2018	Almost complete dissolution of Li and nearly 90% dissolution of Co occurred in at 80  C for 6 h. The reducing agent, ascorbic acid (AA), converts the dissolved Co(III) to Co(II) thereby selective recovery of Co as Co(II)-oxalate is possible.	Ascorbic Acid	117-130	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	214-220
29946976-6	2018	Analysis by X-ray crystallography and X-ray absorption spectroscopy demonstrate that the Co(II) forms of both ACO and CAO1 exhibit a close structural correspondence to the native Fe(II) enzyme forms.	ammonium ferrous sulfate	179-185	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-95
29777723-3	2018	COX-1 and COX-2 activity was determined through measurement of the products of prostaglandin E2 (PGE2) and thromboxane B2 (TXB2) in cell culture supernatants.	Dinoprostone	79-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
29777723-5	2018	Our study confirmed the inhibitory effects of donepezil and rivastigmine on the production of PGE2, TXB2, COX-1 and COX-2 mRNA and protein expression in macrophages.	Donepezil	46-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-121
29777723-5	2018	Our study confirmed the inhibitory effects of donepezil and rivastigmine on the production of PGE2, TXB2, COX-1 and COX-2 mRNA and protein expression in macrophages.	Rivastigmine	60-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-121
29653357-7	2018	However, the oxidation/degradation of NHBrCl in the Co(II)/PMS process reforms HOBr, and, although less in quantity, is oxidized to BrO3- at higher Co(II) and Br- concentrations.	bro3	132-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-58
29653357-7	2018	However, the oxidation/degradation of NHBrCl in the Co(II)/PMS process reforms HOBr, and, although less in quantity, is oxidized to BrO3- at higher Co(II) and Br- concentrations.	bro3	132-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	148-154
29653357-7	2018	However, the oxidation/degradation of NHBrCl in the Co(II)/PMS process reforms HOBr, and, although less in quantity, is oxidized to BrO3- at higher Co(II) and Br- concentrations.	Bromine	40-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-58
29653357-7	2018	However, the oxidation/degradation of NHBrCl in the Co(II)/PMS process reforms HOBr, and, although less in quantity, is oxidized to BrO3- at higher Co(II) and Br- concentrations.	Bromine	40-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	148-154
29653357-8	2018	Thus, the NH3-Cl2 and Cl2-NH3 pretreatment strategies inhibit the BrO3- formation more significantly at lower Co(II) and Br- concentrations.	nh3-cl2	10-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-116
29653357-8	2018	Thus, the NH3-Cl2 and Cl2-NH3 pretreatment strategies inhibit the BrO3- formation more significantly at lower Co(II) and Br- concentrations.	cl2-nh3	22-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-116
29653357-8	2018	Thus, the NH3-Cl2 and Cl2-NH3 pretreatment strategies inhibit the BrO3- formation more significantly at lower Co(II) and Br- concentrations.	bro3	66-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-116
29653357-0	2018	Controlling bromate formation in the Co(II)/peroxymonosulfate process by ammonia, chlorine-ammonia and ammonia-chlorine pretreatment strategies.	Ammonia	73-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-43
32559940-2	2018	Almost complete dissolution of Li and nearly 90% dissolution of Co occurred in at 80  C for 6 h. The reducing agent, ascorbic acid (AA), converts the dissolved Co(III) to Co(II) thereby selective recovery of Co as Co(II)-oxalate is possible.	Cobalt	160-162	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	171-177
29653357-0	2018	Controlling bromate formation in the Co(II)/peroxymonosulfate process by ammonia, chlorine-ammonia and ammonia-chlorine pretreatment strategies.	Chlorine	82-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-43
32559940-2	2018	Almost complete dissolution of Li and nearly 90% dissolution of Co occurred in at 80  C for 6 h. The reducing agent, ascorbic acid (AA), converts the dissolved Co(III) to Co(II) thereby selective recovery of Co as Co(II)-oxalate is possible.	Cobalt	160-162	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	214-220
29653357-0	2018	Controlling bromate formation in the Co(II)/peroxymonosulfate process by ammonia, chlorine-ammonia and ammonia-chlorine pretreatment strategies.	Ammonia	91-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-43
29653357-0	2018	Controlling bromate formation in the Co(II)/peroxymonosulfate process by ammonia, chlorine-ammonia and ammonia-chlorine pretreatment strategies.	ammonia-chlorine	103-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-43
29653357-1	2018	The Co(II)/peroxymonosulfate (Co(II)/PMS) process, producing sulfate radicals (SO4 -), effectively removes organic pollutants in water, while producing a significant amount of bromate (BrO3-) in the presence of bromide (Br-).	sulfate radical	61-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-28
29653357-1	2018	The Co(II)/peroxymonosulfate (Co(II)/PMS) process, producing sulfate radicals (SO4 -), effectively removes organic pollutants in water, while producing a significant amount of bromate (BrO3-) in the presence of bromide (Br-).	sulfate radical	61-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-40
29653357-1	2018	The Co(II)/peroxymonosulfate (Co(II)/PMS) process, producing sulfate radicals (SO4 -), effectively removes organic pollutants in water, while producing a significant amount of bromate (BrO3-) in the presence of bromide (Br-).	so4 -)	79-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-28
29653357-1	2018	The Co(II)/peroxymonosulfate (Co(II)/PMS) process, producing sulfate radicals (SO4 -), effectively removes organic pollutants in water, while producing a significant amount of bromate (BrO3-) in the presence of bromide (Br-).	so4 -)	79-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-40
29653357-1	2018	The Co(II)/peroxymonosulfate (Co(II)/PMS) process, producing sulfate radicals (SO4 -), effectively removes organic pollutants in water, while producing a significant amount of bromate (BrO3-) in the presence of bromide (Br-).	Water	129-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-28
29653357-1	2018	The Co(II)/peroxymonosulfate (Co(II)/PMS) process, producing sulfate radicals (SO4 -), effectively removes organic pollutants in water, while producing a significant amount of bromate (BrO3-) in the presence of bromide (Br-).	Water	129-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-40
29653357-1	2018	The Co(II)/peroxymonosulfate (Co(II)/PMS) process, producing sulfate radicals (SO4 -), effectively removes organic pollutants in water, while producing a significant amount of bromate (BrO3-) in the presence of bromide (Br-).	Bromates	176-183	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-28
29653357-1	2018	The Co(II)/peroxymonosulfate (Co(II)/PMS) process, producing sulfate radicals (SO4 -), effectively removes organic pollutants in water, while producing a significant amount of bromate (BrO3-) in the presence of bromide (Br-).	Bromates	176-183	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-40
29653357-1	2018	The Co(II)/peroxymonosulfate (Co(II)/PMS) process, producing sulfate radicals (SO4 -), effectively removes organic pollutants in water, while producing a significant amount of bromate (BrO3-) in the presence of bromide (Br-).	bro3-	185-190	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-28
29653357-1	2018	The Co(II)/peroxymonosulfate (Co(II)/PMS) process, producing sulfate radicals (SO4 -), effectively removes organic pollutants in water, while producing a significant amount of bromate (BrO3-) in the presence of bromide (Br-).	bro3-	185-190	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-40
29653357-1	2018	The Co(II)/peroxymonosulfate (Co(II)/PMS) process, producing sulfate radicals (SO4 -), effectively removes organic pollutants in water, while producing a significant amount of bromate (BrO3-) in the presence of bromide (Br-).	Bromides	211-218	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-28
29653357-1	2018	The Co(II)/peroxymonosulfate (Co(II)/PMS) process, producing sulfate radicals (SO4 -), effectively removes organic pollutants in water, while producing a significant amount of bromate (BrO3-) in the presence of bromide (Br-).	Bromides	211-218	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-40
29653357-1	2018	The Co(II)/peroxymonosulfate (Co(II)/PMS) process, producing sulfate radicals (SO4 -), effectively removes organic pollutants in water, while producing a significant amount of bromate (BrO3-) in the presence of bromide (Br-).	Bromine	185-187	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-28
29653357-1	2018	The Co(II)/peroxymonosulfate (Co(II)/PMS) process, producing sulfate radicals (SO4 -), effectively removes organic pollutants in water, while producing a significant amount of bromate (BrO3-) in the presence of bromide (Br-).	Bromine	185-187	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-40
29653357-2	2018	This paper investigates the ammonia (NH3) addition, chlorine-ammonia (Cl2-NH3) and ammonia-chlorine (NH3-Cl2) pretreatment strategies in controlling BrO3- formation in 20 min in the Co(II)/PMS process at pH 4.0.	ammonia (nh3)	28-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	182-188
29653357-2	2018	This paper investigates the ammonia (NH3) addition, chlorine-ammonia (Cl2-NH3) and ammonia-chlorine (NH3-Cl2) pretreatment strategies in controlling BrO3- formation in 20 min in the Co(II)/PMS process at pH 4.0.	ammonia-chlorine	83-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	182-188
29653357-2	2018	This paper investigates the ammonia (NH3) addition, chlorine-ammonia (Cl2-NH3) and ammonia-chlorine (NH3-Cl2) pretreatment strategies in controlling BrO3- formation in 20 min in the Co(II)/PMS process at pH 4.0.	nh3-cl2	101-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	182-188
29653357-2	2018	This paper investigates the ammonia (NH3) addition, chlorine-ammonia (Cl2-NH3) and ammonia-chlorine (NH3-Cl2) pretreatment strategies in controlling BrO3- formation in 20 min in the Co(II)/PMS process at pH 4.0.	bro3	149-153	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	182-188
29653357-7	2018	However, the oxidation/degradation of NHBrCl in the Co(II)/PMS process reforms HOBr, and, although less in quantity, is oxidized to BrO3- at higher Co(II) and Br- concentrations.	nhbrcl	38-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-58
29653357-7	2018	However, the oxidation/degradation of NHBrCl in the Co(II)/PMS process reforms HOBr, and, although less in quantity, is oxidized to BrO3- at higher Co(II) and Br- concentrations.	nhbrcl	38-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	148-154
29653357-7	2018	However, the oxidation/degradation of NHBrCl in the Co(II)/PMS process reforms HOBr, and, although less in quantity, is oxidized to BrO3- at higher Co(II) and Br- concentrations.	Promethium	59-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-58
29653357-7	2018	However, the oxidation/degradation of NHBrCl in the Co(II)/PMS process reforms HOBr, and, although less in quantity, is oxidized to BrO3- at higher Co(II) and Br- concentrations.	hypobromous acid	79-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-58
30151381-6	2018	The ability of T. pruinosum EO to inhibit the conversion of Arachidonic Acid (AA) to PGH2 by ovine COX-1 and human recombinant COX-2 was determined using a COX inhibitor screening assay.	Arachidonic Acid	60-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	127-132
30151381-6	2018	The ability of T. pruinosum EO to inhibit the conversion of Arachidonic Acid (AA) to PGH2 by ovine COX-1 and human recombinant COX-2 was determined using a COX inhibitor screening assay.	Prostaglandin H2	85-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	127-132
29949370-5	2018	There are positive shifts of 290 and 260 mV, respectively, for the CoII/CoI and CoIII-H/CoII-H couples from [Co(DPA-1-MPI)(H2O)](PF6)3 to [Co(DPA-3-MPI)(H2O)](PF6)3, with the former being ~32 times as active as the latter in photocatalytic H2 production.	Hydrogen	123-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-71
30140227-5	2018	We also found that Qu-loaded TCs (QTCs) could notably enhance the effect of Qu on inhibiting the NF-kB/COX-2 signaling pathway as well as ameliorating the skin edema caused by UVB radiation.	Quercetin	19-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-108
30140227-5	2018	We also found that Qu-loaded TCs (QTCs) could notably enhance the effect of Qu on inhibiting the NF-kB/COX-2 signaling pathway as well as ameliorating the skin edema caused by UVB radiation.	9-ethyl-N-(3,4,5-trimethoxyphenyl)carbazole-3-sulfonamide	29-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-108
30140227-5	2018	We also found that Qu-loaded TCs (QTCs) could notably enhance the effect of Qu on inhibiting the NF-kB/COX-2 signaling pathway as well as ameliorating the skin edema caused by UVB radiation.	qtcs	34-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-108
30140227-5	2018	We also found that Qu-loaded TCs (QTCs) could notably enhance the effect of Qu on inhibiting the NF-kB/COX-2 signaling pathway as well as ameliorating the skin edema caused by UVB radiation.	Quercetin	76-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-108
29678549-7	2018	The expressions of NF-kB p65, COX-2, pro (BAX, BAK) and anti-apoptotic (BCL-2, BCL-XL) genes were significantly reduced after treatment with FA-RES + DTX-NP.	Docetaxel	150-153	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-35
30060464-8	2018	The best performing polymer in terms of enantioselectivity (alpha = 1.60) was achieved using 4-vinyl pyridine as functional monomer and secondary ligand for the Co(II)-mediated imprinting of S-atenolol in the presence of EDMA as cross-linker in a porogenic mixture of [BMIM][BF4]:DMF:DMSO = 10:1:5, v/v/v.	4-vinylpyridine	93-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	161-166
30060464-8	2018	The best performing polymer in terms of enantioselectivity (alpha = 1.60) was achieved using 4-vinyl pyridine as functional monomer and secondary ligand for the Co(II)-mediated imprinting of S-atenolol in the presence of EDMA as cross-linker in a porogenic mixture of [BMIM][BF4]:DMF:DMSO = 10:1:5, v/v/v.	Atenolol	191-201	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	161-166
30060464-8	2018	The best performing polymer in terms of enantioselectivity (alpha = 1.60) was achieved using 4-vinyl pyridine as functional monomer and secondary ligand for the Co(II)-mediated imprinting of S-atenolol in the presence of EDMA as cross-linker in a porogenic mixture of [BMIM][BF4]:DMF:DMSO = 10:1:5, v/v/v.	EDMA	221-225	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	161-166
30060464-8	2018	The best performing polymer in terms of enantioselectivity (alpha = 1.60) was achieved using 4-vinyl pyridine as functional monomer and secondary ligand for the Co(II)-mediated imprinting of S-atenolol in the presence of EDMA as cross-linker in a porogenic mixture of [BMIM][BF4]:DMF:DMSO = 10:1:5, v/v/v.	1-butyl-3-methylimidazolium	269-273	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	161-166
30060464-8	2018	The best performing polymer in terms of enantioselectivity (alpha = 1.60) was achieved using 4-vinyl pyridine as functional monomer and secondary ligand for the Co(II)-mediated imprinting of S-atenolol in the presence of EDMA as cross-linker in a porogenic mixture of [BMIM][BF4]:DMF:DMSO = 10:1:5, v/v/v.	fluoroboric acid	275-278	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	161-166
30060464-8	2018	The best performing polymer in terms of enantioselectivity (alpha = 1.60) was achieved using 4-vinyl pyridine as functional monomer and secondary ligand for the Co(II)-mediated imprinting of S-atenolol in the presence of EDMA as cross-linker in a porogenic mixture of [BMIM][BF4]:DMF:DMSO = 10:1:5, v/v/v.	Dimethylformamide	280-283	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	161-166
30060464-8	2018	The best performing polymer in terms of enantioselectivity (alpha = 1.60) was achieved using 4-vinyl pyridine as functional monomer and secondary ligand for the Co(II)-mediated imprinting of S-atenolol in the presence of EDMA as cross-linker in a porogenic mixture of [BMIM][BF4]:DMF:DMSO = 10:1:5, v/v/v.	Dimethyl Sulfoxide	284-288	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	161-166
29949370-5	2018	There are positive shifts of 290 and 260 mV, respectively, for the CoII/CoI and CoIII-H/CoII-H couples from [Co(DPA-1-MPI)(H2O)](PF6)3 to [Co(DPA-3-MPI)(H2O)](PF6)3, with the former being ~32 times as active as the latter in photocatalytic H2 production.	Hydrogen	123-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-84
29975380-5	2018	Most interestingly, the mixed-metal systems can show a higher blocking temperature than the Co(ii) compound, suggesting that the randomly distributed metal ions have synergistic effects on slow relaxation of magnetization.	Metals	150-155	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-98
30001620-0	2018	Influence of a "Dangling" Co(II) Ion Bound to a [MnCo3O4] Oxo Cubane.	[mnco3o4] oxo cubane	48-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-32
29953212-2	2018	The paramagnetic 15-electron Co(II) complexes of the type [Co{kappa2 N,N"-5-R-NC4H2-2-C(H) N(2,6-iPr2-C6H3)}(Py)Cl] (3a-e; Py = pyridine) were prepared by salt metathesis of CoCl2(Py)4 with the respective potassium salts 2a-e in moderate to good yields.	co{kappa2 n,n"-5-r-nc4h2-2-c(h) n	59-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-35
30021004-0	2018	Feline calicivirus- and murine norovirus-induced COX-2/PGE2 signaling pathway has proviral effects.	Dinoprostone	55-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-54
29951660-0	2018	A Co(ii) framework derived from a tris(4-(triazol-1-yl)phenyl)amine redox-active linker: an electrochemical and magnetic study.	tris[4-(triazol-1-yl)phenyl]amine	34-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	2-8
29951660-4	2018	Furthermore, the incorporation of a paramagnetic Co(ii) metal ion into the framework caused 1 to show spin-flop behaviour as the result of a field-induced magnetic transition.	Metals	56-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-55
29951660-5	2018	The incorporation of two flexible ligands and Co(ii) metal ions represents a feasible approach for the advancement of multifunctional materials.	Metals	53-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-52
29975380-3	2018	These behaviors are quite different from the parent Co(ii) and Ni(ii) materials, and even a small amount of metal replacement can cause significant magnetic changes.	Metals	108-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-58
29975380-3	2018	These behaviors are quite different from the parent Co(ii) and Ni(ii) materials, and even a small amount of metal replacement can cause significant magnetic changes.	Metals	108-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-57
29975380-5	2018	Most interestingly, the mixed-metal systems can show a higher blocking temperature than the Co(ii) compound, suggesting that the randomly distributed metal ions have synergistic effects on slow relaxation of magnetization.	Metals	30-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-98
30037344-10	2018	Quantitative real-time PCR analysis revealed that curcumin, but not rapamycin, reduced the levels of inflammatory markers IL-6 and COX-2 in cultured astrocytes that were challenged with IL-1beta.	Curcumin	50-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-136
30021004-6	2018	Treatment with pharmacological inhibitors or transfection of small interfering RNAs (siRNAs) against COX-2 enzyme significantly reduced the production of PGE2 as well as FCV and MNV replications.	Dinoprostone	154-158	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-106
30021004-7	2018	The inhibitory effects of these pharmacological inhibitors against COX-2 enzyme on the replication of both viruses were restored by the addition of PGE2.	Dinoprostone	148-152	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-72
30021004-9	2018	These data indicate that the COX-2/PGE2 signaling pathway has proviral effects for the replication of FCV and MNV, and pharmacological inhibitors against these enzymes serve as potential therapeutic candidates for treating FCV and MNV infections.	Dinoprostone	35-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34
29847693-1	2018	A CoII /porphyrinate-based macrocycle in the presence of a 3,5-diphenylpyridine axial ligand functions as an endotopic ligand to direct the assembly of [2]rotaxanes from diazo and styrene half-threads, by radical-carbene-transfer reactions, in excellent 95 % yield.	2,6-diphenylpyridine	59-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	2-6
29847693-1	2018	A CoII /porphyrinate-based macrocycle in the presence of a 3,5-diphenylpyridine axial ligand functions as an endotopic ligand to direct the assembly of [2]rotaxanes from diazo and styrene half-threads, by radical-carbene-transfer reactions, in excellent 95 % yield.	Rotaxanes	155-164	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	2-6
29847693-1	2018	A CoII /porphyrinate-based macrocycle in the presence of a 3,5-diphenylpyridine axial ligand functions as an endotopic ligand to direct the assembly of [2]rotaxanes from diazo and styrene half-threads, by radical-carbene-transfer reactions, in excellent 95 % yield.	diazo	170-175	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	2-6
29847693-1	2018	A CoII /porphyrinate-based macrocycle in the presence of a 3,5-diphenylpyridine axial ligand functions as an endotopic ligand to direct the assembly of [2]rotaxanes from diazo and styrene half-threads, by radical-carbene-transfer reactions, in excellent 95 % yield.	Styrene	180-187	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	2-6
29847693-1	2018	A CoII /porphyrinate-based macrocycle in the presence of a 3,5-diphenylpyridine axial ligand functions as an endotopic ligand to direct the assembly of [2]rotaxanes from diazo and styrene half-threads, by radical-carbene-transfer reactions, in excellent 95 % yield.	carbene	213-220	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	2-6
29847693-3	2018	A careful quantitative analysis of the product distribution afforded from the rotaxane self-assembly reaction shows that the CoII /porphyrinate subunit is still active after formation of the mechanical bond and, upon coordination of an additional diazo half-thread derivative, promotes a novel intercomponent C-H insertion reaction to yield a new rotaxane-like species.	Rotaxanes	78-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-129
29847693-3	2018	A careful quantitative analysis of the product distribution afforded from the rotaxane self-assembly reaction shows that the CoII /porphyrinate subunit is still active after formation of the mechanical bond and, upon coordination of an additional diazo half-thread derivative, promotes a novel intercomponent C-H insertion reaction to yield a new rotaxane-like species.	porphyrinate	131-143	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-129
29847693-3	2018	A careful quantitative analysis of the product distribution afforded from the rotaxane self-assembly reaction shows that the CoII /porphyrinate subunit is still active after formation of the mechanical bond and, upon coordination of an additional diazo half-thread derivative, promotes a novel intercomponent C-H insertion reaction to yield a new rotaxane-like species.	Rotaxanes	347-355	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-129
29847693-4	2018	This unexpected intercomponent C-H insertion illustrates the distinct reactivity brought to the CoII /porphyrinate catalyst by the mechanical bond.	porphyrinate	102-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-100
29953212-2	2018	The paramagnetic 15-electron Co(II) complexes of the type [Co{kappa2 N,N"-5-R-NC4H2-2-C(H) N(2,6-iPr2-C6H3)}(Py)Cl] (3a-e; Py = pyridine) were prepared by salt metathesis of CoCl2(Py)4 with the respective potassium salts 2a-e in moderate to good yields.	2,6-ipr2-c6h3)}(py)cl	93-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-35
30038488-1	2018	Introduction: In this study, the radiation-enhancing effects of combined treatment with nimotuzumab, a humanized EGFR-blocking antibody, and celecoxib, a COX-2 selective inhibitor, in human nasopharyngeal carcinoma (NPC) cells were investigated.	Celecoxib	141-150	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	154-159
29953212-2	2018	The paramagnetic 15-electron Co(II) complexes of the type [Co{kappa2 N,N"-5-R-NC4H2-2-C(H) N(2,6-iPr2-C6H3)}(Py)Cl] (3a-e; Py = pyridine) were prepared by salt metathesis of CoCl2(Py)4 with the respective potassium salts 2a-e in moderate to good yields.	pyridine	109-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-35
29953212-2	2018	The paramagnetic 15-electron Co(II) complexes of the type [Co{kappa2 N,N"-5-R-NC4H2-2-C(H) N(2,6-iPr2-C6H3)}(Py)Cl] (3a-e; Py = pyridine) were prepared by salt metathesis of CoCl2(Py)4 with the respective potassium salts 2a-e in moderate to good yields.	pyridine	128-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-35
29953212-2	2018	The paramagnetic 15-electron Co(II) complexes of the type [Co{kappa2 N,N"-5-R-NC4H2-2-C(H) N(2,6-iPr2-C6H3)}(Py)Cl] (3a-e; Py = pyridine) were prepared by salt metathesis of CoCl2(Py)4 with the respective potassium salts 2a-e in moderate to good yields.	cocl2(py)4	174-184	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-35
29953212-2	2018	The paramagnetic 15-electron Co(II) complexes of the type [Co{kappa2 N,N"-5-R-NC4H2-2-C(H) N(2,6-iPr2-C6H3)}(Py)Cl] (3a-e; Py = pyridine) were prepared by salt metathesis of CoCl2(Py)4 with the respective potassium salts 2a-e in moderate to good yields.	potassium salts	205-220	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-35
29953212-9	2018	The Co(II) family 3a-d, on activation with K(HBEt3), catalyzed the hydroboration of several alpha-olefins with pinacolborane, in good to high yields (50-80%).	alpha-olefins	92-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
29953212-9	2018	The Co(II) family 3a-d, on activation with K(HBEt3), catalyzed the hydroboration of several alpha-olefins with pinacolborane, in good to high yields (50-80%).	4,4,5,5-tetramethyl(1,3,2)dioxaborolane	111-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
29986680-12	2018	Moreover, ROS scavenger (NAC) and Nox inhibitor (DPI) attenuated CBNPs-induced expressions of iNOS and COX-2.	Reactive Oxygen Species	10-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-108
29922779-1	2018	Using an asymmetric tetradentate ligand N-((6-(1H-pyrazol-1-yl)pyridin-2-yl)methylene)benzohydrazide (pypzbeyz), two high-coordinate 3d transition metal compounds [CoII(pypzbeyz)(NO3)2] (1) and [FeII(pypzbeyz)2](BF4)2(CH3CN) (2) have been synthesized and characterized by structural and magnetic measurements.	n-((6-(1h-pyrazol-1-yl)pyridin-2-yl)methylene)benzohydrazide	40-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	164-168
29986680-12	2018	Moreover, ROS scavenger (NAC) and Nox inhibitor (DPI) attenuated CBNPs-induced expressions of iNOS and COX-2.	3-aminodiphenyleneiodium	49-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-108
29986680-12	2018	Moreover, ROS scavenger (NAC) and Nox inhibitor (DPI) attenuated CBNPs-induced expressions of iNOS and COX-2.	cbnps	65-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-108
30310585-3	2018	Herein, we report the synthesis of a novel redox active ligand, [ibaps]3-, which binds to transition metals such as FeII and CoII in a meridional fashion through the three anionic nitrogen atoms and provides additional coordination sites for other ligands.	ibaps	65-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-129
29702455-8	2018	XPS analysis confirmed that substitution of copper could promote the cycle of CoII/CoIII, thus enhance the catalytic efficiency for PMS activation.	Copper	44-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-82
29702455-9	2018	The facilitated cycle of CoII/CoIII played a crucial role in the generation of sulfate radicals, hydroxyl radicals and singlet oxygen.	Sulfates	79-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-29
29702455-9	2018	The facilitated cycle of CoII/CoIII played a crucial role in the generation of sulfate radicals, hydroxyl radicals and singlet oxygen.	Hydroxyl Radical	97-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-29
29702455-9	2018	The facilitated cycle of CoII/CoIII played a crucial role in the generation of sulfate radicals, hydroxyl radicals and singlet oxygen.	Singlet Oxygen	119-133	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-29
27645771-6	2018	We have further identified eCBs as the retrograde messengers and shown that PAK1 regulates the eCB signaling via restricting the tissue level of AEA by promoting synaptic expression of COX-2, a key enzyme to oxidize AEA.	ecbs	27-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	185-190
27645771-6	2018	We have further identified eCBs as the retrograde messengers and shown that PAK1 regulates the eCB signaling via restricting the tissue level of AEA by promoting synaptic expression of COX-2, a key enzyme to oxidize AEA.	anandamide	145-148	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	185-190
27645771-6	2018	We have further identified eCBs as the retrograde messengers and shown that PAK1 regulates the eCB signaling via restricting the tissue level of AEA by promoting synaptic expression of COX-2, a key enzyme to oxidize AEA.	anandamide	216-219	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	185-190
29894170-0	2018	Magnetic Properties of Mononuclear Co(II) Complexes with Carborane Ligands.	carborane	57-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-41
29894170-9	2018	Overall, our results suggest that o-carborane-incorporated Co(II) complexes are worthwhile candidates for experimental exploration as single-ion molecular magnets.	o-Carborane	34-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
29982425-4	2018	Under in vitro conditions, NO-Aspirin significantly reduced the proliferation and survival of tumorigenic bronchial cell line (1170) and non-small cell lung cancer (NSCLC) cell lines (A549, H1650, H1975 and HCC827) and colony formation by NSCLC cells at sub- or low micromolar concentrations (&lt;=1 microM for 1170 cells and &lt;=6 microM for NSCLC cells) in a COX-2 independent manner.	Aspirin	30-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	362-367
30310585-3	2018	Herein, we report the synthesis of a novel redox active ligand, [ibaps]3-, which binds to transition metals such as FeII and CoII in a meridional fashion through the three anionic nitrogen atoms and provides additional coordination sites for other ligands.	Nitrogen	180-188	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-129
29653184-7	2018	Furthermore, the mRNA expression of inflammatory mediators such as Il-1beta, Il-6, iNos, and Cox-2 was more attenuated in 17beta-estradiol-treated group than in vehicle-treated group.	Estradiol	122-138	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-98
29774604-0	2018	Plant Sunscreen and Co(II)/(III) Porphyrins for UV-Resistant and Thermally Stable Perovskite Solar Cells: From Natural to Artificial.	Porphyrins	33-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-26
29774604-0	2018	Plant Sunscreen and Co(II)/(III) Porphyrins for UV-Resistant and Thermally Stable Perovskite Solar Cells: From Natural to Artificial.	perovskite	82-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-26
29758489-4	2018	Fisetin significantly inhibited COX-2 expression and reduced prostaglandin E2 production, and it suppressed the levels of IL-8, CCL5, monocyte chemotactic protein 1, tumor necrosis factor alpha, and IL-6.	fisetin	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-37
29514844-0	2018	COX-2/PGE2 Axis Regulates HIF2alpha Activity to Promote Hepatocellular Carcinoma Hypoxic Response and Reduce the Sensitivity of Sorafenib Treatment.	Sorafenib	128-137	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
29514844-3	2018	We sought to determine whether the COX-2/PGE2 axis is involved in the regulatory mechanisms of HIF2alpha activity and of sorafenib resistance in hypoxic HCC cells.Experimental Design: The cell viability, migration, and invasion abilities were measured to analyze the effects of HIF2alpha on hypoxic HCC cells.	Sorafenib	121-130	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40
29514844-4	2018	Both in vitro and in vivo HCC models were used to determine whether the COX-2/PGE2 axis is a driver of HIF2alpha level and activity, which then reduces the sensitivity of sorafenib treatment in hypoxic HCC cells.Results: Under hypoxic conditions, the COX-2/PGE2 axis effectively stabilized HIF2alpha and increased its level and activity via decreasing von Hippel-Lindau protein (p-VHL) level, and also enhanced HIF2alpha activity by promoting HIF2alpha nuclear translocation via MAPK pathway.	Sorafenib	171-180	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
29514844-4	2018	Both in vitro and in vivo HCC models were used to determine whether the COX-2/PGE2 axis is a driver of HIF2alpha level and activity, which then reduces the sensitivity of sorafenib treatment in hypoxic HCC cells.Results: Under hypoxic conditions, the COX-2/PGE2 axis effectively stabilized HIF2alpha and increased its level and activity via decreasing von Hippel-Lindau protein (p-VHL) level, and also enhanced HIF2alpha activity by promoting HIF2alpha nuclear translocation via MAPK pathway.	Sorafenib	171-180	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	251-256
29896263-3	2018	Nimesulide, a selective COX-2 inhibitor, can induce cell apoptosis, resulting in an anti-cancer effect.	nimesulide	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
29896263-11	2018	Furthermore, nimesulide enhanced expression of phosphatase and tensin homolog (PTEN), and decreased the expression level of COX-2 and vascular endothelial growth factor.	nimesulide	13-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	124-129
29396848-0	2018	Arsenic promotes the COX2/PGE2-SOX2 axis to increase the malignant stemness properties of urothelial cells.	Arsenic	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-25
29396848-5	2018	Following gene set enrichment analyses of arsenic-exposed and arsenic-unexposed cells, we found COX2 as an enriched gene for oncogenic signature.	Arsenic	42-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-100
29673704-4	2018	Only concurrent but not individual exposure to OTA and CIT at nanomolar concentrations led to (i) an increase of TNF protein and mRNA, (ii) a decrease of COX-2 protein and mRNA, (iii) a decrease of E-cadherin protein and (iv) an increase of vimentin and alpha-SMA protein.	Citrinin	55-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	154-159
29396848-5	2018	Following gene set enrichment analyses of arsenic-exposed and arsenic-unexposed cells, we found COX2 as an enriched gene for oncogenic signature.	Arsenic	62-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-100
29396848-6	2018	Mechanistically, arsenic-induced COX2/PGE2 increases SOX2 expression that eventually promotes malignant stem cell generation and repopulation.	Arsenic	17-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-37
29396848-7	2018	In urine samples from 90 subjects exposed to arsenic and 91 control subjects, we found a significant linear correlation between SOX2 and COX2 expression and the potential of SOX2 and COX2 expression as urinary markers to detect subjects exposed to arsenic.	Arsenic	45-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-141
29396848-7	2018	In urine samples from 90 subjects exposed to arsenic and 91 control subjects, we found a significant linear correlation between SOX2 and COX2 expression and the potential of SOX2 and COX2 expression as urinary markers to detect subjects exposed to arsenic.	Arsenic	45-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	183-187
29396848-7	2018	In urine samples from 90 subjects exposed to arsenic and 91 control subjects, we found a significant linear correlation between SOX2 and COX2 expression and the potential of SOX2 and COX2 expression as urinary markers to detect subjects exposed to arsenic.	Arsenic	248-255	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-141
29396848-7	2018	In urine samples from 90 subjects exposed to arsenic and 91 control subjects, we found a significant linear correlation between SOX2 and COX2 expression and the potential of SOX2 and COX2 expression as urinary markers to detect subjects exposed to arsenic.	Arsenic	248-255	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	183-187
29396848-10	2018	In conclusion, the COX2/PGE2-SOX2 axis promotes arsenic-induced malignant stem cell transformation.	Dinoprostone	24-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-23
29396848-10	2018	In conclusion, the COX2/PGE2-SOX2 axis promotes arsenic-induced malignant stem cell transformation.	Arsenic	48-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-23
31949699-2	2018	We have previously shown that exogenous H2S exerts its biological effects on hepatoma, glioma, and esophageal cancer cells through the activation of NF-kappaB, p38-MAPK/ERK1/2-COX-2, and HSP90 pathways.	hydrogen sulfite	40-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	176-181
29514844-6	2018	More importantly, COX-2-specific inhibitors synergistically enhanced the antitumor activity of sorafenib treatment.Conclusions: Our data obtained demonstrate that the COX/PGE2 axis acts as a regulator of HIF2alpha expression and activity to promote HCC development and reduce sorafenib sensitivity by constitutively activating the TGFalpha/EGFR pathway.	Sorafenib	95-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-23
29514844-6	2018	More importantly, COX-2-specific inhibitors synergistically enhanced the antitumor activity of sorafenib treatment.Conclusions: Our data obtained demonstrate that the COX/PGE2 axis acts as a regulator of HIF2alpha expression and activity to promote HCC development and reduce sorafenib sensitivity by constitutively activating the TGFalpha/EGFR pathway.	Dinoprostone	171-175	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-23
29514844-6	2018	More importantly, COX-2-specific inhibitors synergistically enhanced the antitumor activity of sorafenib treatment.Conclusions: Our data obtained demonstrate that the COX/PGE2 axis acts as a regulator of HIF2alpha expression and activity to promote HCC development and reduce sorafenib sensitivity by constitutively activating the TGFalpha/EGFR pathway.	Sorafenib	276-285	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-23
29514844-7	2018	This study highlights the potential of COX-2-specific inhibitors for HCC treatment and particularly for enhancing the response to sorafenib treatment.	Sorafenib	130-139	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-44
29940605-10	2018	Moreover, BK-induced up-regulation of p-p38, NF-kappaB p-p65, NLRP3, ASC, caspase-1, and COX-2 was dose-dependently down-regulated by propofol treatment.	Propofol	134-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-94
29714814-1	2018	A dinuclear CoII complex, [Co2 (tphz)(tpy)2 ]n+ (n=4, 3 or 2; tphz: tetrapyridophenazine; tpy: terpyridine), has been assembled using the redox-active and strongly complexing tphz bridging ligand.	[co2 (tphz)(tpy)2 ]n+	26-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-16
29714814-1	2018	A dinuclear CoII complex, [Co2 (tphz)(tpy)2 ]n+ (n=4, 3 or 2; tphz: tetrapyridophenazine; tpy: terpyridine), has been assembled using the redox-active and strongly complexing tphz bridging ligand.	tphz	32-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-16
29714814-1	2018	A dinuclear CoII complex, [Co2 (tphz)(tpy)2 ]n+ (n=4, 3 or 2; tphz: tetrapyridophenazine; tpy: terpyridine), has been assembled using the redox-active and strongly complexing tphz bridging ligand.	tetrapyridophenazine	68-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-16
29714814-1	2018	A dinuclear CoII complex, [Co2 (tphz)(tpy)2 ]n+ (n=4, 3 or 2; tphz: tetrapyridophenazine; tpy: terpyridine), has been assembled using the redox-active and strongly complexing tphz bridging ligand.	tpy	38-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-16
29714814-1	2018	A dinuclear CoII complex, [Co2 (tphz)(tpy)2 ]n+ (n=4, 3 or 2; tphz: tetrapyridophenazine; tpy: terpyridine), has been assembled using the redox-active and strongly complexing tphz bridging ligand.	2,2':6',2''-Terpyridine	95-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-16
29714814-1	2018	A dinuclear CoII complex, [Co2 (tphz)(tpy)2 ]n+ (n=4, 3 or 2; tphz: tetrapyridophenazine; tpy: terpyridine), has been assembled using the redox-active and strongly complexing tphz bridging ligand.	tphz	62-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-16
29940605-11	2018	CONCLUSIONS Propofol prevents inflammation in MG-63 cells by regulating p38MAPK-NF-kappaB pathway, NLRP3 inflammasome, and COX-2 expression.	Propofol	12-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-128
29862809-6	2018	Notably, we find that an electrostatic interaction between Co(II) and one hydrogen atom from a thiophenolate group in the xz plane increases the energy of the d x2- y2 orbital, leading to the nearly equal population with d xy and strong magnetic anisotropy.	Hydrogen	74-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
29932110-6	2018	Of these, only (2-(1,2-diphenyl-1H-indol-3-yl)ethanamine (DPIE) showed a synergistic increase in inflammatory molecules and cytokine production (IL-6, IL-8, and COX-2) at both mRNA and protein levels in IL-1&amp;beta;-stimulated GFs.	1,2-Diphenyltryptamine	16-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	161-166
29932110-6	2018	Of these, only (2-(1,2-diphenyl-1H-indol-3-yl)ethanamine (DPIE) showed a synergistic increase in inflammatory molecules and cytokine production (IL-6, IL-8, and COX-2) at both mRNA and protein levels in IL-1&amp;beta;-stimulated GFs.	dpie	58-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	161-166
29774906-3	2018	The reaction of 1 with LiCH2SiMe3 afforded the dark purple, paramagnetic [Co(CyP*NaCNHC)CH2SiMe3] (3) with a low spin d7 CoII; the electronic configurations of 1 and 3 were corroborated by EPR spectroscopy.	(Trimethylsilyl)methyllithium	23-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-125
29774906-6	2018	Reduction of CoII to CoI by silanes is uncommon.	Silanes	28-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-17
29799201-0	2018	Rational Design of Co(II) Dominant and Oxygen Vacancy Defective CuCo2O4@CQDs Hollow Spheres for Enhanced Overall Water Splitting and Supercapacitor Performance.	cuco2o4	64-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-25
29799201-0	2018	Rational Design of Co(II) Dominant and Oxygen Vacancy Defective CuCo2O4@CQDs Hollow Spheres for Enhanced Overall Water Splitting and Supercapacitor Performance.	Water	113-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-25
29799201-2	2018	XPS analysis shows the CuCo2O4@CQDs possesses the Co(II)-rich surface associated with the oxygen vacancies, which can effectively boost the Faradaic reactions and oxygen evolution reaction (OER) activity.	cuco2o4	23-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-56
29799201-2	2018	XPS analysis shows the CuCo2O4@CQDs possesses the Co(II)-rich surface associated with the oxygen vacancies, which can effectively boost the Faradaic reactions and oxygen evolution reaction (OER) activity.	Oxygen	90-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-56
29799201-2	2018	XPS analysis shows the CuCo2O4@CQDs possesses the Co(II)-rich surface associated with the oxygen vacancies, which can effectively boost the Faradaic reactions and oxygen evolution reaction (OER) activity.	Oxygen	163-169	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-56
29799201-5	2018	The synergy of Co(II)-rich surface, oxygen vacancies, and well-defined 3D hollow structures facilitates the subsequent surface electrochemical reactions.	Oxygen	36-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-20
29862809-6	2018	Notably, we find that an electrostatic interaction between Co(II) and one hydrogen atom from a thiophenolate group in the xz plane increases the energy of the d x2- y2 orbital, leading to the nearly equal population with d xy and strong magnetic anisotropy.	thiophenolate	95-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
29870229-0	2018	Random Co(II)-Ni(II) Ferromagnetic Chains Showing Coexistent Antiferromagnetism, Metamagnetism, and Single-Chain Magnetism.	Nickel(2+)	14-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	7-13
29942116-10	2018	Co-treatment of indomethacin inhibited AB1010-induced COX-2 expression leading to an additive effect in inhibition of cell viability and PGE2 production in tested TCC cells.	Indomethacin	16-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-59
29753720-1	2018	In the present study, a nanocomposite of f-MWCNTs-chitosan-Co was prepared by the immobilization of Co(II) on f-MWCNTs-chitosan by a self-assembly method and used for the quantitative determination of paracetamol (PR).	Acetaminophen	201-212	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-106
30038944-1	2018	Recent work suggests the selective Cox-2 inhibitor celecoxib delays progression to androgen independence in hormone sensitive prostate cancer (HSPC) through inhibition of the androgen receptor (AR) and ErbB signaling.	Celecoxib	51-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40
29942116-10	2018	Co-treatment of indomethacin inhibited AB1010-induced COX-2 expression leading to an additive effect in inhibition of cell viability and PGE2 production in tested TCC cells.	Dinoprostone	137-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-59
29942116-11	2018	Conclusion: Co-treatment of RTKIs with indomethacin inhibited cell viability and AB1010-induced COX-2 expression resulting in decreased PGE2 production in tested TCC cells.	masitinib	81-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-101
29850706-6	2018	The electrochemical properties of complex 5 were investigated in DMF, and the Co(ii)/Co(iii) redox couple was found to be negatively shifted compared to that of complex 1, while the ligand-based processes became irreversible.	Dimethylformamide	65-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-84
29850706-6	2018	The electrochemical properties of complex 5 were investigated in DMF, and the Co(ii)/Co(iii) redox couple was found to be negatively shifted compared to that of complex 1, while the ligand-based processes became irreversible.	co(iii)	85-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-84
28923363-4	2018	In fact, pure flavonoids (e.g., quercetin, genistein, hesperetin, epigallocatechin-3-gallate) or enriched-extracts, can reduce the expression of pro-inflammatory cytokines (IL-6, TNF-alpha, IL-1beta and COX-2), down-regulate inflammatory markers and prevent neural damage.	hesperetin	54-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	203-208
30008606-8	2018	ETMI exerted its anti-inflammatory activity by modulating the main inflammatory indicators such as cyclooxygenase (COX)-2, interleukin (IL)-6, inducible nitric oxide synthase (iNOS), tumor necrosis factor (TNF)-alpha, and nitric oxide (NO) in a dose-dependent manner.	etmi	0-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-121
28923363-4	2018	In fact, pure flavonoids (e.g., quercetin, genistein, hesperetin, epigallocatechin-3-gallate) or enriched-extracts, can reduce the expression of pro-inflammatory cytokines (IL-6, TNF-alpha, IL-1beta and COX-2), down-regulate inflammatory markers and prevent neural damage.	Flavonoids	14-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	203-208
28923363-4	2018	In fact, pure flavonoids (e.g., quercetin, genistein, hesperetin, epigallocatechin-3-gallate) or enriched-extracts, can reduce the expression of pro-inflammatory cytokines (IL-6, TNF-alpha, IL-1beta and COX-2), down-regulate inflammatory markers and prevent neural damage.	Quercetin	32-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	203-208
28923363-4	2018	In fact, pure flavonoids (e.g., quercetin, genistein, hesperetin, epigallocatechin-3-gallate) or enriched-extracts, can reduce the expression of pro-inflammatory cytokines (IL-6, TNF-alpha, IL-1beta and COX-2), down-regulate inflammatory markers and prevent neural damage.	epigallocatechin gallate	66-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	203-208
28923363-4	2018	In fact, pure flavonoids (e.g., quercetin, genistein, hesperetin, epigallocatechin-3-gallate) or enriched-extracts, can reduce the expression of pro-inflammatory cytokines (IL-6, TNF-alpha, IL-1beta and COX-2), down-regulate inflammatory markers and prevent neural damage.	Genistein	43-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	203-208
29634657-0	2018	Muramyl Dipeptide Induces Reactive Oxygen Species Generation Through the NOD2/COX-2/NOX4 Signaling Pathway in Human Umbilical Vein Endothelial Cells.	Acetylmuramyl-Alanyl-Isoglutamine	0-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-83
29877658-4	2018	The cardiovascular toxicity of these drugs in the direction of HF follow different pathways respect to their related vascular thrombosis toxicity and involves, in particular, the renal prostaglandins, PGE2 and prostacyclin, mostly synthesized by COX-2.	Prostaglandins	185-199	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	246-251
29877658-4	2018	The cardiovascular toxicity of these drugs in the direction of HF follow different pathways respect to their related vascular thrombosis toxicity and involves, in particular, the renal prostaglandins, PGE2 and prostacyclin, mostly synthesized by COX-2.	Dinoprostone	201-205	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	246-251
29877658-4	2018	The cardiovascular toxicity of these drugs in the direction of HF follow different pathways respect to their related vascular thrombosis toxicity and involves, in particular, the renal prostaglandins, PGE2 and prostacyclin, mostly synthesized by COX-2.	Epoprostenol	210-222	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	246-251
29928230-4	2018	Rofecoxib is a prescription COX-2 selective Non-Steroidal Anti-Inflammatory Drugs (NSAID) approved in 1999.	rofecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
29869728-3	2018	Methylation of the carboxylate group in the relatively nonselective COX inhibitor indomethacin confers significant COX-2 selectivity.	carboxylate	19-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-120
29869728-3	2018	Methylation of the carboxylate group in the relatively nonselective COX inhibitor indomethacin confers significant COX-2 selectivity.	Indomethacin	82-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-120
29869728-4	2018	Several other modifications converting indomethacin into a COX-2 selective inhibitor have been reported.	Indomethacin	39-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-64
29869728-5	2018	Earlier experimental and computational studies on neutral indomethacin derivatives suggest that the methyl ester derivative likely binds to COX-2 with a similar binding mode as that observed for the parent indomethacin.	Indomethacin	58-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-145
29869728-5	2018	Earlier experimental and computational studies on neutral indomethacin derivatives suggest that the methyl ester derivative likely binds to COX-2 with a similar binding mode as that observed for the parent indomethacin.	methyl ester	100-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-145
29869728-5	2018	Earlier experimental and computational studies on neutral indomethacin derivatives suggest that the methyl ester derivative likely binds to COX-2 with a similar binding mode as that observed for the parent indomethacin.	Indomethacin	206-218	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-145
29869728-6	2018	However, docking studies followed by molecular dynamics simulations revealed two possible binding modes in COX-2 for indomethacin methyl ester, which differs from the experimental binding mode found for indomethacin.	Indomethacin Methyl Ester	117-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-112
29869728-6	2018	However, docking studies followed by molecular dynamics simulations revealed two possible binding modes in COX-2 for indomethacin methyl ester, which differs from the experimental binding mode found for indomethacin.	Indomethacin	117-129	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-112
29869728-7	2018	Both alternative binding modes might explain the observed COX-2 selectivity of indomethacin methyl ester.	Indomethacin Methyl Ester	79-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
29634657-0	2018	Muramyl Dipeptide Induces Reactive Oxygen Species Generation Through the NOD2/COX-2/NOX4 Signaling Pathway in Human Umbilical Vein Endothelial Cells.	Reactive Oxygen Species	26-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-83
29634657-10	2018	Collectively, we indicated that NOD2 played a leading role in MDP-induced COX-2/NOX4/ROS signaling pathway in HUVECs, which was a novel regulatory mechanism in the progress of ROS generation.	Reactive Oxygen Species	85-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
29634657-10	2018	Collectively, we indicated that NOD2 played a leading role in MDP-induced COX-2/NOX4/ROS signaling pathway in HUVECs, which was a novel regulatory mechanism in the progress of ROS generation.	Reactive Oxygen Species	176-179	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
29561200-1	2018	Graphene oxide regulates cox2 in human embryonic kidney 293 T cells via epigenetic mechanisms: dynamic chromosomal interactions.	graphene oxide	0-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-29
29229353-0	2018	Novel 1,4-benzothazines obliterate COX-2 mediated JAK-2/STAT-3 signals with potential regulation of oxidative and metabolic stress during colorectal cancer.	1,4-benzothazines	6-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40
29928483-1	2018	Arachidonic acid (AA) can be converted into prostaglandins (PGs) or leukotrienes (LTs) by the enzymatic actions of cyclooxygenases (COX-1 and COX-2) or 5-lipoxygenase (5-LO), respectively.	Arachidonic Acid	0-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	142-147
29928483-1	2018	Arachidonic acid (AA) can be converted into prostaglandins (PGs) or leukotrienes (LTs) by the enzymatic actions of cyclooxygenases (COX-1 and COX-2) or 5-lipoxygenase (5-LO), respectively.	Prostaglandins	44-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	142-147
29928483-1	2018	Arachidonic acid (AA) can be converted into prostaglandins (PGs) or leukotrienes (LTs) by the enzymatic actions of cyclooxygenases (COX-1 and COX-2) or 5-lipoxygenase (5-LO), respectively.	Prostaglandins	60-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	142-147
29928483-1	2018	Arachidonic acid (AA) can be converted into prostaglandins (PGs) or leukotrienes (LTs) by the enzymatic actions of cyclooxygenases (COX-1 and COX-2) or 5-lipoxygenase (5-LO), respectively.	Leukotrienes	68-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	142-147
29928483-1	2018	Arachidonic acid (AA) can be converted into prostaglandins (PGs) or leukotrienes (LTs) by the enzymatic actions of cyclooxygenases (COX-1 and COX-2) or 5-lipoxygenase (5-LO), respectively.	Leukotrienes	82-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	142-147
29229353-1	2018	1,4-benzothiazines have ameliorative effects through inhibition of COX-2 mediated STAT-3 pathways at G-protein couple receptor site.	1,4-benzothiazine	0-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-72
29229353-13	2018	In conclusion, our study provided the evidence towards better antiproliferative effect of AR13 and AR15 in DMH-induced CRC through the blockade of COX-2/JAK-2/STAT-3 signal transduction pathway and could be demonstrated as useful anti-CRC candidate molecules for future anticancer therapy.	Dimethylhydrazines	107-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-152
29899697-4	2018	We found that icariin downregulated the protein expression of STAT3 downstream target gene products such as Bcl-2, Bcl-xl, survivin, IAP-1/2, COX-2, VEGF, and matrix metallopeptidase 9 (MMP-9) in a concentration-dependent manner.	icariin	14-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	142-147
30023927-3	2018	The significant reduction in the formation of prostaglandin E2 in the lipopolysaccharide-treated (COX-2-activated) human whole blood, almost no change in the production of thromboxane B2 in the calcium ionophore-treated (COX-1-activated) sample of human whole blood, and the mechanistic studies on Swiss albino mice ensured that compound 6 is selective for COX-2.	Dinoprostone	46-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-103
29974839-1	2018	Dimethyl-celecoxib (DMC), a close derivative of celecoxib (CXB) with a low COX-2 inhibitory function, exhibits significant anti-neoplastic properties.	dimethyl-celecoxib	0-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
29974839-1	2018	Dimethyl-celecoxib (DMC), a close derivative of celecoxib (CXB) with a low COX-2 inhibitory function, exhibits significant anti-neoplastic properties.	dmc	20-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
29974839-1	2018	Dimethyl-celecoxib (DMC), a close derivative of celecoxib (CXB) with a low COX-2 inhibitory function, exhibits significant anti-neoplastic properties.	Celecoxib	9-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
29974839-1	2018	Dimethyl-celecoxib (DMC), a close derivative of celecoxib (CXB) with a low COX-2 inhibitory function, exhibits significant anti-neoplastic properties.	Celecoxib	59-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
29974839-7	2018	Down-regulation of the COX-2 mRNA expression in the celecoxib-treated group was significant compared with that in the DMC-treated group.	Celecoxib	52-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-28
29974839-7	2018	Down-regulation of the COX-2 mRNA expression in the celecoxib-treated group was significant compared with that in the DMC-treated group.	dmc	118-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-28
29974839-9	2018	Owing to the more potent growth inhibitory effects of DMC compared to that of celecoxib, it may be important to conduct research on the anticancer application of this compound, which can reduce the side effects relating to COX2 inhibition.	dmc	54-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	223-227
29862139-10	2018	Furthermore, TcES-treated eyes were shown to have increased IL-10 expression, with a corresponding reduction in IL-6 and COX-2 expression as well as reduction in NF-kappaB phosphorylation.	tces	13-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-126
29872310-0	2018	Resveratrol inhibits the proliferation of A549 cells by inhibiting the expression of COX-2.	Resveratrol	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-90
29853736-8	2018	In our multivariate Cox model, high coexpression of cytoplasmic IDO1/COX2 was found to be an independent predictor of poor outcome in CRC (HR = 2.218, 95%CI: 1.011-4.48, P = 0.047) and celecoxib subgroup patients (HR = 3.210, 95%CI: 1.074-9.590, P = 0.037).	Celecoxib	185-194	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-73
29726862-0	2018	Natural and synthetic avenanthramides activate caspases 2, 8, 3 and downregulate hTERT, MDR1 and COX-2 genes in CaCo-2 and Hep3B cancer cells.	avenanthramide-2C	22-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
29872310-9	2018	Resveratrol at 60 mumol/L significantly inhibited A549 cells proliferation, S phase cells proportion and COX-2 expression (P&lt;0.01).	Resveratrol	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-110
29872310-11	2018	OD570 values, colony formation rate and S phase cells proportion of resveratrol + siRNA-COX-2 group were much lower than those of other groups (P&lt;0.01).	Resveratrol	68-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-93
29872310-12	2018	Conclusion: Resveratrol inhibits A549 cells proliferation by inhibiting COX-2 expression.	Resveratrol	12-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
29507184-7	2018	Interestingly, overexpression of the EMT factor, ZEB1, which declines during cAMP-induced type II cell differentiation, increased pri-miR-199a and reduced the expression of the targets NF-kappaB/p50 and COX-2.	Cyclic AMP	77-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	203-208
29741888-0	2018	Electron and Oxygen Atom Transfer Chemistry of Co(II) in a Proton Responsive, Redox Active Ligand Environment.	Oxygen	13-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-53
29741888-1	2018	The bis-pyrazolato pyridine complex LCo(PEt3)2 serves as a masked form of three-coordinate CoII and shows diverse reactivity in its reaction with several potential outer sphere oxidants and oxygen atom transfer reagents.	bis-pyrazolato pyridine	4-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-95
29741888-1	2018	The bis-pyrazolato pyridine complex LCo(PEt3)2 serves as a masked form of three-coordinate CoII and shows diverse reactivity in its reaction with several potential outer sphere oxidants and oxygen atom transfer reagents.	lco(pet3)2	36-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-95
29938022-3	2018	Experimental investigations, supported by electronic structure calculations, reveal that catalysis commences when nitrate binds to the two-electron reduced species CoII(DIM-), where cobalt and the macrocycle are each reduced by a single electron.	Nitrates	114-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	164-168
29938022-3	2018	Experimental investigations, supported by electronic structure calculations, reveal that catalysis commences when nitrate binds to the two-electron reduced species CoII(DIM-), where cobalt and the macrocycle are each reduced by a single electron.	Cobalt	182-188	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	164-168
30701895-3	2018	Patented microcrystalline glucosamine sulfate (pCGS) is likely to have an effect similar to NSAIDS because it can cause decrease of COX-2 and PGE2 gene expression.	Glucosamine	26-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-137
29501151-6	2018	As a proof of concept and example, the enhancement of the chemiluminescence signal produced by Co(II) on the luminol-H2O2 reaction in alkaline medium was used for illustrating this implementation determining vitamin B12 in pharmaceutical preparations (after mineralization for releasing Co(II)).	Luminol	109-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-101
29501151-6	2018	As a proof of concept and example, the enhancement of the chemiluminescence signal produced by Co(II) on the luminol-H2O2 reaction in alkaline medium was used for illustrating this implementation determining vitamin B12 in pharmaceutical preparations (after mineralization for releasing Co(II)).	Luminol	109-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	287-293
29501151-6	2018	As a proof of concept and example, the enhancement of the chemiluminescence signal produced by Co(II) on the luminol-H2O2 reaction in alkaline medium was used for illustrating this implementation determining vitamin B12 in pharmaceutical preparations (after mineralization for releasing Co(II)).	Hydrogen Peroxide	117-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-101
29501151-6	2018	As a proof of concept and example, the enhancement of the chemiluminescence signal produced by Co(II) on the luminol-H2O2 reaction in alkaline medium was used for illustrating this implementation determining vitamin B12 in pharmaceutical preparations (after mineralization for releasing Co(II)).	Hydrogen Peroxide	117-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	287-293
29501151-6	2018	As a proof of concept and example, the enhancement of the chemiluminescence signal produced by Co(II) on the luminol-H2O2 reaction in alkaline medium was used for illustrating this implementation determining vitamin B12 in pharmaceutical preparations (after mineralization for releasing Co(II)).	Vitamin B 12	208-219	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-101
29501151-6	2018	As a proof of concept and example, the enhancement of the chemiluminescence signal produced by Co(II) on the luminol-H2O2 reaction in alkaline medium was used for illustrating this implementation determining vitamin B12 in pharmaceutical preparations (after mineralization for releasing Co(II)).	Vitamin B 12	208-219	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	287-293
29655084-3	2018	Anti-convulsant activity of both potent COX-2 inhibitors was assessed in sc-PTZ induced seizure test and MTL-1 excellently protected animals against PTZ induced seizure at the dose of 30 mg/kg.	Pentylenetetrazole	76-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
29748523-0	2018	Unprecedented Fluorescent Dinuclear CoII and ZnII Coordination Compounds with a Symmetric Bis(salamo)-Like Tetraoxime.	bis(salamo)	90-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-40
29748523-0	2018	Unprecedented Fluorescent Dinuclear CoII and ZnII Coordination Compounds with a Symmetric Bis(salamo)-Like Tetraoxime.	tetraoxime	107-117	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-40
29748523-1	2018	Two unprecedented homometallic CoII and ZnII coordination compounds, [M2(L)(OCH3)][M2(L)(OAc)] (MII = CoII (1) and ZnII (2)), with a novel symmetric bis(salamo)-like tetraoxime ligand H3L were synthesized and characterized by elemental analyses, infrafred (IR), ultraviolet-visible spectroscopy (UV-Vis), fluorescent spectra and single-crystal X-ray diffraction analyses.	(l)(oac)	85-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-35
29748523-1	2018	Two unprecedented homometallic CoII and ZnII coordination compounds, [M2(L)(OCH3)][M2(L)(OAc)] (MII = CoII (1) and ZnII (2)), with a novel symmetric bis(salamo)-like tetraoxime ligand H3L were synthesized and characterized by elemental analyses, infrafred (IR), ultraviolet-visible spectroscopy (UV-Vis), fluorescent spectra and single-crystal X-ray diffraction analyses.	Methicillin	96-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-35
29748523-1	2018	Two unprecedented homometallic CoII and ZnII coordination compounds, [M2(L)(OCH3)][M2(L)(OAc)] (MII = CoII (1) and ZnII (2)), with a novel symmetric bis(salamo)-like tetraoxime ligand H3L were synthesized and characterized by elemental analyses, infrafred (IR), ultraviolet-visible spectroscopy (UV-Vis), fluorescent spectra and single-crystal X-ray diffraction analyses.	Zinc	115-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-35
29683320-4	2018	KCO-4 inhibited the oversecretion of inflammatory mediators (i.e., NO, TNF-alpha, IL-1beta, IL-8, iNOS, and COX-2).	kco-4	0-5	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-113
30701895-3	2018	Patented microcrystalline glucosamine sulfate (pCGS) is likely to have an effect similar to NSAIDS because it can cause decrease of COX-2 and PGE2 gene expression.	pcgs	47-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-137
29938025-5	2018	2017, 82, 2703-2712) and a Co(0)-Co(ii) redox mechanism was proposed.	co(0)	27-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-39
29697966-1	2018	In this work we present a systematic computational study of the structural and magnetic properties of a layered family of Co(II) hydroxichlorides, obeying to the general formula Co(OH)2- xCl x(H2O) y.	co(oh)2- xcl x	178-192	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-128
29697966-1	2018	In this work we present a systematic computational study of the structural and magnetic properties of a layered family of Co(II) hydroxichlorides, obeying to the general formula Co(OH)2- xCl x(H2O) y.	Water	193-196	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-128
29697966-6	2018	Moreover, our results suggest that the presence of interlayer water stabilizes the material and at the same time strongly modifies the electronic environment of tetrahedral Co(II), leading to a further drop of the band gap.	Water	62-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	173-179
29733109-6	2018	The examined derivatives showed interesting pharmacological activity, and the compound N-[2-[2,4-difluorophenyl)thio]-4-oxo-6-phenylthieno[3,2-d]pyridine-34H-yl]methanesulphonamide (7) was excellent COX-2 inhibitor.	n-[2-[2,4-difluorophenyl)thio]-4-oxo-6-phenylthieno[3,2-d]pyridine-34h-yl]methanesulphonamide	87-180	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	199-204
29477476-6	2018	Among 10 tumor related genes tested in 5 CRC cell lines, DHA and EPA induced promoter demethylation of Cox2 in HT29/219, p14 and PPARgamma in HCT116, and ECAD in SW742 cells.	dehydroacetic acid	57-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-107
29667993-1	2018	One-pot reaction between 8-hydroxyquinoline-2-carboxaldehyde (HQC) and tris(hydroxymethyl)aminomethane (TRIS) followed by in situ cyclization yielded an oxazolidine based ligand which produced four mononuclear complexes of MnII(1), CoII(2), NiII(3), ZnII(4), a tetranuclear iron (FeIII4) complex (5) and a trinuclear cobalt (CoIICoIII2) complex (6).	8-Hydroxyquinoline-2-carboxaldehyde	25-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	232-236
29667993-1	2018	One-pot reaction between 8-hydroxyquinoline-2-carboxaldehyde (HQC) and tris(hydroxymethyl)aminomethane (TRIS) followed by in situ cyclization yielded an oxazolidine based ligand which produced four mononuclear complexes of MnII(1), CoII(2), NiII(3), ZnII(4), a tetranuclear iron (FeIII4) complex (5) and a trinuclear cobalt (CoIICoIII2) complex (6).	HQC	62-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	232-236
29667993-1	2018	One-pot reaction between 8-hydroxyquinoline-2-carboxaldehyde (HQC) and tris(hydroxymethyl)aminomethane (TRIS) followed by in situ cyclization yielded an oxazolidine based ligand which produced four mononuclear complexes of MnII(1), CoII(2), NiII(3), ZnII(4), a tetranuclear iron (FeIII4) complex (5) and a trinuclear cobalt (CoIICoIII2) complex (6).	Tromethamine	71-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	232-236
29667993-1	2018	One-pot reaction between 8-hydroxyquinoline-2-carboxaldehyde (HQC) and tris(hydroxymethyl)aminomethane (TRIS) followed by in situ cyclization yielded an oxazolidine based ligand which produced four mononuclear complexes of MnII(1), CoII(2), NiII(3), ZnII(4), a tetranuclear iron (FeIII4) complex (5) and a trinuclear cobalt (CoIICoIII2) complex (6).	Tromethamine	104-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	232-236
29667993-1	2018	One-pot reaction between 8-hydroxyquinoline-2-carboxaldehyde (HQC) and tris(hydroxymethyl)aminomethane (TRIS) followed by in situ cyclization yielded an oxazolidine based ligand which produced four mononuclear complexes of MnII(1), CoII(2), NiII(3), ZnII(4), a tetranuclear iron (FeIII4) complex (5) and a trinuclear cobalt (CoIICoIII2) complex (6).	oxazolidine	153-164	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	232-236
29555649-3	2018	The mechanism of resveratrol action requires nuclear accumulation of inducible cyclooxygenase (COX)-2 and its complexation with phosphorylated ERK1/2.	Resveratrol	17-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-101
29555649-4	2018	In this study, we examined the mechanism by which T4 impairs resveratrol-induced antiproliferation in human ovarian cancer cells and found that T4 inhibited resveratrol-induced nuclear accumulation of COX-2.	Resveratrol	61-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	201-206
29555649-4	2018	In this study, we examined the mechanism by which T4 impairs resveratrol-induced antiproliferation in human ovarian cancer cells and found that T4 inhibited resveratrol-induced nuclear accumulation of COX-2.	Resveratrol	157-168	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	201-206
29555649-6	2018	Knockdown of PD-L1 by small hairpin RNA (shRNA) relieved the inhibitory effect of T4 on resveratrol-induced nuclear accumulation of COX-2- and COX-2/p53-dependent gene expression.	Resveratrol	88-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-137
29555649-6	2018	Knockdown of PD-L1 by small hairpin RNA (shRNA) relieved the inhibitory effect of T4 on resveratrol-induced nuclear accumulation of COX-2- and COX-2/p53-dependent gene expression.	Resveratrol	88-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	143-148
29922432-7	2018	Results: Co-administration of selective and non-selective COX-2 inhibitors with DEW led to a remarkable increase in cytotoxicity and apoptosis of A549 cells.	2-azanyl-1-(6,7-dihydro-4~{H}-thieno[3,2-c]pyridin-5-yl)ethanone	80-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
28989083-13	2018	Co-treatment with resveratrol also significantly restored iNOS and COX-2 levels in Abeta-treated hNSCs.	Resveratrol	18-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-72
29492773-5	2018	The ability of these metal ions to produce oligosaccharide adduct ions by ESI had the general trend: Ca(II) &gt; Mg(II) &gt; Ni(II) &gt; Co(II) &gt; Zn(II) &gt; Cu(II) &gt; Na(I) &gt; K(I) &gt; Al(III)   Fe(III)   Cr(III).	Metals	21-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-143
29492773-5	2018	The ability of these metal ions to produce oligosaccharide adduct ions by ESI had the general trend: Ca(II) &gt; Mg(II) &gt; Ni(II) &gt; Co(II) &gt; Zn(II) &gt; Cu(II) &gt; Na(I) &gt; K(I) &gt; Al(III)   Fe(III)   Cr(III).	Oligosaccharides	43-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-143
29492773-5	2018	The ability of these metal ions to produce oligosaccharide adduct ions by ESI had the general trend: Ca(II) &gt; Mg(II) &gt; Ni(II) &gt; Co(II) &gt; Zn(II) &gt; Cu(II) &gt; Na(I) &gt; K(I) &gt; Al(III)   Fe(III)   Cr(III).	Magnesium	113-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-143
29492773-5	2018	The ability of these metal ions to produce oligosaccharide adduct ions by ESI had the general trend: Ca(II) &gt; Mg(II) &gt; Ni(II) &gt; Co(II) &gt; Zn(II) &gt; Cu(II) &gt; Na(I) &gt; K(I) &gt; Al(III)   Fe(III)   Cr(III).	Zinc	149-151	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-143
29492773-5	2018	The ability of these metal ions to produce oligosaccharide adduct ions by ESI had the general trend: Ca(II) &gt; Mg(II) &gt; Ni(II) &gt; Co(II) &gt; Zn(II) &gt; Cu(II) &gt; Na(I) &gt; K(I) &gt; Al(III)   Fe(III)   Cr(III).	Copper	161-163	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-143
29492773-5	2018	The ability of these metal ions to produce oligosaccharide adduct ions by ESI had the general trend: Ca(II) &gt; Mg(II) &gt; Ni(II) &gt; Co(II) &gt; Zn(II) &gt; Cu(II) &gt; Na(I) &gt; K(I) &gt; Al(III)   Fe(III)   Cr(III).	Aluminum	194-196	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-143
29492773-5	2018	The ability of these metal ions to produce oligosaccharide adduct ions by ESI had the general trend: Ca(II) &gt; Mg(II) &gt; Ni(II) &gt; Co(II) &gt; Zn(II) &gt; Cu(II) &gt; Na(I) &gt; K(I) &gt; Al(III)   Fe(III)   Cr(III).	Chromium	214-216	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-143
28948649-0	2018	Association of GPIa and COX-2 gene polymorphism with aspirin resistance.	Aspirin	53-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
28948649-1	2018	OBJECTIVE: This study aimed to explore the association between GPIa, COX-2 gene polymorphisms and aspirin resistance in the ischemic stroke patients from the southern part of Jiangsu province.	Aspirin	98-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-74
29487225-9	2018	A patient with a CDKN2A-inactivating and a CTNNB1-activating mutation received matched treatment: palbociclib (CDK4/6 inhibitor) and celecoxib (COX-2/Wnt inhibitor); des-gamma-carboxy prothrombin level decreased by 84% at 2 months (1,410 to 242 ng/mL [normal: &lt;=7.4 ng/mL]; alpha fetoprotein [AFP] low at baseline).	Celecoxib	133-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	144-149
29616098-4	2018	Additional data suggested that a COX-2 inhibitor caused a marked reduction of NICD level in comparison with a control group treated with dimethyl sulfoxide.	Dimethyl Sulfoxide	137-155	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-38
29351170-11	2018	After adjustment for maternal autoimmune diseases, concomitant medication use, and other risk factors, COX-2 inhibitor use in late pregnancy was associated with a 2.46-fold increased risk of prematurity (adjusted OR, 2.46; 95% confidence interval, 1.28-4.72) compared to nonuse; only late pregnancy exposure to celecoxib was found to increase the risk (adjusted OR, 3.41; 95% confidence interval, 1.29-9.02).	Celecoxib	311-320	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-108
29413962-5	2018	Moreover, we demonstrated that the expression of NF-kappaB, COX-2, IL-8, and MMP-13 were elevated subsequent to inhibition of SIRT1/AMPK/PGC-1alpha/PPAR-gamma pathway by homocysteine, thereby causing detrimental effects on chondrocytes.	Homocysteine	170-182	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-65
29294438-7	2018	Furthermore, TiO2 NP exposure activates inflammatory responses by increasing mRNA levels of TNF-alpha, iNOS, and COX-2.	tio2 np	13-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-118
29294438-8	2018	Consistently, our targeted metabolomic analysis showed significantly increased production of COX-2 metabolites including PGD2, PGE2, and 15d-PGJ2.	Dinoprostone	127-131	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-98
29698447-1	2018	Drugs that inhibit cyclooxygenase (COX)-2 and the metabolism of arachidonic acid (ARA) to prostaglandin E2 are potent anti-inflammatory agents used widely in the treatment of joint and muscle pain.	Dinoprostone	90-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-41
29294438-8	2018	Consistently, our targeted metabolomic analysis showed significantly increased production of COX-2 metabolites including PGD2, PGE2, and 15d-PGJ2.	15-deoxyprostaglandin J2	137-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-98
29546906-4	2018	The engineered self-assembly of the pyridyl-2-cobalt complex (L1 Co(II)) was employed to selectively detect malathion while the pyridyl-4-cobalt complex (L2 Co(II)) could estimate azamethiphos fluorimetrically up to a detection limit of 9.2 nM and 11 nM, respectively.	pyridyl-2-cobalt	36-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-71
29546906-4	2018	The engineered self-assembly of the pyridyl-2-cobalt complex (L1 Co(II)) was employed to selectively detect malathion while the pyridyl-4-cobalt complex (L2 Co(II)) could estimate azamethiphos fluorimetrically up to a detection limit of 9.2 nM and 11 nM, respectively.	Malathion	108-117	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-71
29546906-4	2018	The engineered self-assembly of the pyridyl-2-cobalt complex (L1 Co(II)) was employed to selectively detect malathion while the pyridyl-4-cobalt complex (L2 Co(II)) could estimate azamethiphos fluorimetrically up to a detection limit of 9.2 nM and 11 nM, respectively.	pyridyl-4-cobalt	128-144	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	157-163
29546906-4	2018	The engineered self-assembly of the pyridyl-2-cobalt complex (L1 Co(II)) was employed to selectively detect malathion while the pyridyl-4-cobalt complex (L2 Co(II)) could estimate azamethiphos fluorimetrically up to a detection limit of 9.2 nM and 11 nM, respectively.	azamethiphos	180-192	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	157-163
29674687-0	2018	Celecoxib exerts protective effects in the vascular endothelium via COX-2-independent activation of AMPK-CREB-Nrf2 signalling.	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-73
29611559-5	2018	In order to confirm the effect of intermolecular FRET in photocatalysis, the excited state lifetime of the energy donor dye PPIX has been modulated by inserting d10 (ZnII) and d7 (CoII) metal ions in the central position of the dye (PP(Zn) and PP(Co)).	protoporphyrin IX	124-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	180-184
29674687-4	2018	Celecoxib derivative 2,5-dimethyl-celecoxib (DMC) which lacks COX-2 inhibition also upregulated HO-1, implicating a COX-2-independent mechanism.	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
29674687-4	2018	Celecoxib derivative 2,5-dimethyl-celecoxib (DMC) which lacks COX-2 inhibition also upregulated HO-1, implicating a COX-2-independent mechanism.	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-121
29674687-4	2018	Celecoxib derivative 2,5-dimethyl-celecoxib (DMC) which lacks COX-2 inhibition also upregulated HO-1, implicating a COX-2-independent mechanism.	2,5-dimethylcelecoxib	21-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
29674687-4	2018	Celecoxib derivative 2,5-dimethyl-celecoxib (DMC) which lacks COX-2 inhibition also upregulated HO-1, implicating a COX-2-independent mechanism.	2,5-dimethylcelecoxib	21-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-121
29674687-4	2018	Celecoxib derivative 2,5-dimethyl-celecoxib (DMC) which lacks COX-2 inhibition also upregulated HO-1, implicating a COX-2-independent mechanism.	2,5-dimethylcelecoxib	45-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-121
29436750-0	2018	A Moisture-Stable 3D Microporous CoII -Metal-Organic Framework with Potential for Highly Selective CO2 Separation under Ambient Conditions.	Metals	39-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-37
29436750-0	2018	A Moisture-Stable 3D Microporous CoII -Metal-Organic Framework with Potential for Highly Selective CO2 Separation under Ambient Conditions.	N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)-4-((4-fluorobenzyl)oxy)pyridine-2,6-dicarboxamide	99-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-37
29462704-2	2018	Sodium salicylate, a COX-2 inhibitor, can induce tinnitus in high doses.	Sodium Salicylate	0-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-26
29553263-7	2018	Magnetic measurement showed a general property, but the catalytic experiments demonstrated that CoII- and Zn II-containing POMs displayed a higher efficiency for the selective oxidation of thioanisole to sulfoxide.	methylphenylsulfide	189-200	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-100
29719610-8	2018	PGE2 levels, a manifestation of COX-2 activity were increased during hypoxia, but were reduced by the combination during both hypoxia and normoxia.	Dinoprostone	0-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-37
29626212-7	2018	Co-treatment of high glucose with palmitic acid potentiated the expression of several DR-relevant angiogenic and inflammatory targets, including PTGS2 (COX-2) and CXCL8 (IL-8).	Glucose	21-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-157
29626212-7	2018	Co-treatment of high glucose with palmitic acid potentiated the expression of several DR-relevant angiogenic and inflammatory targets, including PTGS2 (COX-2) and CXCL8 (IL-8).	Palmitic Acid	34-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-157
29528627-2	2018	Despite the coordination environment of Co(II) being of similar symmetry, the four complexes exhibit distinct dynamic magnetic properties owing to their packing arrangements and dipole-dipole interactions.	dipole-dipole	178-191	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
29553263-7	2018	Magnetic measurement showed a general property, but the catalytic experiments demonstrated that CoII- and Zn II-containing POMs displayed a higher efficiency for the selective oxidation of thioanisole to sulfoxide.	sulfoxide	204-213	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-100
29553723-1	2018	A chiral Co(II)-based coordination polymer, [Co3(pimda)2(H2O)5] (1, H3pimda = 2-propyl-1H-imidazole-4,5-dicarboxylic acid) with 3D hyperkagome topology is reported.	Polymers	35-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	9-14
29553723-1	2018	A chiral Co(II)-based coordination polymer, [Co3(pimda)2(H2O)5] (1, H3pimda = 2-propyl-1H-imidazole-4,5-dicarboxylic acid) with 3D hyperkagome topology is reported.	co3(pimda)2(h2o)	45-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	9-14
29553723-1	2018	A chiral Co(II)-based coordination polymer, [Co3(pimda)2(H2O)5] (1, H3pimda = 2-propyl-1H-imidazole-4,5-dicarboxylic acid) with 3D hyperkagome topology is reported.	h3pimda	68-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	9-14
29553723-1	2018	A chiral Co(II)-based coordination polymer, [Co3(pimda)2(H2O)5] (1, H3pimda = 2-propyl-1H-imidazole-4,5-dicarboxylic acid) with 3D hyperkagome topology is reported.	2-propyl-1H-imidazole-4,5-dicarboxylic Acid	78-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	9-14
29553723-2	2018	Upon heating/cooling, the water molecules which are coordinated to a pair of crystallographically symmetric Co(II) ions are removed/recovered discretely in two steps, giving [Co3(pimda)2(H2O)4] (2) and [Co3(pimda)2(H2O)3] (3), which is evidenced by the reversible single-crystal-to-single-crystal (SCSC) structural transformations.	Water	26-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-114
29553723-2	2018	Upon heating/cooling, the water molecules which are coordinated to a pair of crystallographically symmetric Co(II) ions are removed/recovered discretely in two steps, giving [Co3(pimda)2(H2O)4] (2) and [Co3(pimda)2(H2O)3] (3), which is evidenced by the reversible single-crystal-to-single-crystal (SCSC) structural transformations.	co3	175-178	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-114
29553723-2	2018	Upon heating/cooling, the water molecules which are coordinated to a pair of crystallographically symmetric Co(II) ions are removed/recovered discretely in two steps, giving [Co3(pimda)2(H2O)4] (2) and [Co3(pimda)2(H2O)3] (3), which is evidenced by the reversible single-crystal-to-single-crystal (SCSC) structural transformations.	Water	187-190	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-114
29553723-2	2018	Upon heating/cooling, the water molecules which are coordinated to a pair of crystallographically symmetric Co(II) ions are removed/recovered discretely in two steps, giving [Co3(pimda)2(H2O)4] (2) and [Co3(pimda)2(H2O)3] (3), which is evidenced by the reversible single-crystal-to-single-crystal (SCSC) structural transformations.	co3	203-206	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-114
29553723-3	2018	As the coordination geometry of the two Co(II) ions changes from octahedron to trigonal bipyramid, obvious color change from pink for 1 to dark violet for 2 and 3 is observed.	octahedron	65-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-46
29425717-3	2018	In this study, we designed a novel local sustained gene delivery system by using cyclooxygenase (COX-1 and COX-2)-engineered miRNA plasmid/nanoparticles embedded in hyaluronic acid (HA) hydrogel to reduce flexor tendon adhesions.	Hyaluronic Acid	165-180	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-112
29357430-8	2018	The cyclooxygenase (COX)-2/prostaglandin (PG) E2 pathway has been well documented as a contributor of AQP reduction in obstructed kidney; thus, we detected the levels of COX-1/2 and microsomal prostaglandin E synthase 1 (mPGES-1) in kidney and PGE2 secretion in urine.	Dinoprostone	244-248	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-26
29351444-8	2018	Moreover, coculture conditions induced COX-2 in HLFs but not in T cells, suggesting that T cells deliver an activating signal to HLFs, which in turn produce anti-fibrotic prostaglandins.	Prostaglandins	171-185	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-44
29502024-1	2018	Herein we report the synthesis of a new series of aromatic sulfamates designed considering the sulfonamide COX-2 selective inhibitors celecoxib and valdecoxib as lead compounds.	valdecoxib	148-158	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-112
29400411-0	2018	Design, synthesis, and biological evaluation of novel 1,2-diaryl-4-substituted-benzylidene-5(4H)-imidazolone derivatives as cytotoxic agents and COX-2/LOX inhibitors.	1,2-diaryl-4-substituted-benzylidene-5(4h)-imidazolone	54-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-150
29400411-5	2018	The synthesized compounds showed selectivity toward COX-2 rather than COX-1, and the IC50 values (0.25-1.7 microM) were lower than that of indomethacin (IC50  = 9.47 microM) and somewhat higher than that of celecoxib (IC50  = 0.071 microM).	Indomethacin	139-151	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-57
29400411-5	2018	The synthesized compounds showed selectivity toward COX-2 rather than COX-1, and the IC50 values (0.25-1.7 microM) were lower than that of indomethacin (IC50  = 9.47 microM) and somewhat higher than that of celecoxib (IC50  = 0.071 microM).	Celecoxib	207-216	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-57
29400411-6	2018	The selectivity index for COX-2 of the oxazole derivative 4e (SI = 3.67) was nearly equal to that of celecoxib (SI = 3.66).	Oxazoles	39-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-31
29400411-8	2018	The most active compound 4c (4-chlorobenzoxazole derivative) was found to have dual COX-2/LOX activity.	4-chlorobenzoxazole	29-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-89
29400411-10	2018	They linked to COX-2 through the N atom of the azole scaffold, while C O of the oxazolone moiety was responsible for the binding to amino acids inside the LOX active site.	Nitrogen	33-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-20
29400411-10	2018	They linked to COX-2 through the N atom of the azole scaffold, while C O of the oxazolone moiety was responsible for the binding to amino acids inside the LOX active site.	Azoles	47-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-20
29355485-0	2018	COX16 is required for assembly of cytochrome c oxidase in human cells and is involved in copper delivery to COX2.	Copper	89-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-112
29355485-10	2018	Finally, we found that copper supplementation increases COX activity and restores normal steady state levels of COX subunits in COX16 knockout cells, indicating that, even in the absence of a canonical copper binding motif, COX16 could be involved in copper delivery to COX2.	Copper	23-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	270-274
29226424-5	2018	Poly(I:C) induced the production of prostaglandin E2 in OHSCs by increasing cyclooxygenase (COX-2) and microsomal prostaglandin E synthase (mPGES)-1.	poly	0-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-97
29226424-5	2018	Poly(I:C) induced the production of prostaglandin E2 in OHSCs by increasing cyclooxygenase (COX-2) and microsomal prostaglandin E synthase (mPGES)-1.	Carbon	7-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-97
29226424-5	2018	Poly(I:C) induced the production of prostaglandin E2 in OHSCs by increasing cyclooxygenase (COX-2) and microsomal prostaglandin E synthase (mPGES)-1.	Iodine	5-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-97
29226424-5	2018	Poly(I:C) induced the production of prostaglandin E2 in OHSCs by increasing cyclooxygenase (COX-2) and microsomal prostaglandin E synthase (mPGES)-1.	Dinoprostone	36-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-97
28819782-0	2018	The effects of beta-D-mannuronic acid (M2000), as a novel NSAID, on COX1 and COX2 activities and gene expression in ankylosing spondylitis patients and the murine monocyte/macrophage, J774 cell line.	mannuronic acid	15-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-81
29505957-7	2018	Collectively, these findings indicated that COX-2 is not only a stimulus of YAP but also a target of Hippo-YAP pathway, thus forming a positive feedback circuit, COX-2-PGE2-EP2-Galphas-beta-catenin-YAP-COX-2.	Dinoprostone	168-172	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-49
29518743-5	2018	Andrographolide suppressed NF-kappaB activation as well as COX-2 expression induced by TLR3 or TLR4 agonists.	andrographolide	0-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-64
29068147-6	2018	The application capability is demonstrated by the analysis of a set of COX2 inhibitors with respect to Isoxicam.	isoxicam	103-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-75
29505957-7	2018	Collectively, these findings indicated that COX-2 is not only a stimulus of YAP but also a target of Hippo-YAP pathway, thus forming a positive feedback circuit, COX-2-PGE2-EP2-Galphas-beta-catenin-YAP-COX-2.	Dinoprostone	168-172	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	162-167
29505957-7	2018	Collectively, these findings indicated that COX-2 is not only a stimulus of YAP but also a target of Hippo-YAP pathway, thus forming a positive feedback circuit, COX-2-PGE2-EP2-Galphas-beta-catenin-YAP-COX-2.	Dinoprostone	168-172	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	162-167
29570987-5	2018	In vitro studies have revealed that EGCG can contain carcinogenesis by altering the molecules involved in multiple signal transduction pathways like ERK, VEGF, COX2, NEAT, Ras-GTPase, and kinases.	epigallocatechin gallate	36-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	160-164
29552221-3	2018	In the prostaglandin-dependent pathways, inhibition of cyclooxygenase (COX), particularly COX-2, is the primary mechanism known to be involved in aspirin-induced CRC suppression.	Prostaglandins	7-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-95
29552221-3	2018	In the prostaglandin-dependent pathways, inhibition of cyclooxygenase (COX), particularly COX-2, is the primary mechanism known to be involved in aspirin-induced CRC suppression.	Aspirin	146-153	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-95
29720833-0	2018	Evidence for the Involvement of COX-2/VEGF and PTEN/Pl3K/AKT Pathway the Mechanism of Oroxin B Treated Liver Cancer.	oroxin B	86-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-37
29577621-4	2018	Thorough spectroscopic characterizations reveal that strong chemical couplings at the hybrid interface trigger charge transfer from CoII in the oxide to FeIII in the LDHs through the interfacial Fe O Co bond, leading to considerable amounts of high oxidation state CoIII sites present in the hybrid.	Oxides	144-149	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-136
29408043-1	2018	Arachidonic acid is metabolized by cyclooxygenases (COX-1 and COX-2) into various prostanoids which exert different functions in mammalian physiology.	Arachidonic Acid	0-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
29408043-1	2018	Arachidonic acid is metabolized by cyclooxygenases (COX-1 and COX-2) into various prostanoids which exert different functions in mammalian physiology.	Prostaglandins	82-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
29614741-0	2018	Synthesis and Fluorescence Properties of a New Heterotrinuclear Co(II)-Ce(III)Complex Constructed from a bis(salamo)-Type Tetraoxime Ligand.	ce(iii)	71-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-69
29273868-4	2018	On the other hand, the toll like receptor 3 (TLR3) stimulant poly(I:C) increased expression of both COX-2 and PGES, resulting in a significant increase in PGE2 levels.	Dinoprostone	155-159	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-105
29273868-5	2018	This effect was reversed upon COX-2 inhibition with indomethacin or PGES downregulation by siRNA.	Indomethacin	52-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-35
29273868-8	2018	In summary, the present study reveals that upregulation of PGES via TLR3 is critical for BM-MSCs-mediated immunosuppression by PGE2 secretion via the COX-2/PGE2 pathway.	Dinoprostone	127-131	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	150-155
29273868-8	2018	In summary, the present study reveals that upregulation of PGES via TLR3 is critical for BM-MSCs-mediated immunosuppression by PGE2 secretion via the COX-2/PGE2 pathway.	Dinoprostone	156-160	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	150-155
29332822-3	2018	After photocatalysis, the complex of Fe-humic substances could be transformed into Fe(III) ions, the interference of colored organic matter (e.g., aqueous humic substance) was removed, Fe(III) was enriched selectively onto NMCP with the coexistence of interference metal ions (e.g. Co(II) and Cd(II)) and then transformed into Fe(II) by hydroxylamine and photoreduction and for colorimetric analysis.	Iron	37-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	282-288
29332822-3	2018	After photocatalysis, the complex of Fe-humic substances could be transformed into Fe(III) ions, the interference of colored organic matter (e.g., aqueous humic substance) was removed, Fe(III) was enriched selectively onto NMCP with the coexistence of interference metal ions (e.g. Co(II) and Cd(II)) and then transformed into Fe(II) by hydroxylamine and photoreduction and for colorimetric analysis.	humic	40-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	282-288
29332822-3	2018	After photocatalysis, the complex of Fe-humic substances could be transformed into Fe(III) ions, the interference of colored organic matter (e.g., aqueous humic substance) was removed, Fe(III) was enriched selectively onto NMCP with the coexistence of interference metal ions (e.g. Co(II) and Cd(II)) and then transformed into Fe(II) by hydroxylamine and photoreduction and for colorimetric analysis.	ferric sulfate	185-192	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	282-288
29596308-7	2018	We show that an aberrant over-expression of cyclooxygenase (COX)-2, which is an inflammation-associated enzyme, occurring in 40-50% of breast cancer patients leads to tumor progression and metastasis due to multiple cellular events resulting from an increased prostaglandin (PG) E2 production in the tumor milieu.	Dinoprostone	260-281	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-66
29614741-0	2018	Synthesis and Fluorescence Properties of a New Heterotrinuclear Co(II)-Ce(III)Complex Constructed from a bis(salamo)-Type Tetraoxime Ligand.	bis(salamo)	105-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-69
29614741-0	2018	Synthesis and Fluorescence Properties of a New Heterotrinuclear Co(II)-Ce(III)Complex Constructed from a bis(salamo)-Type Tetraoxime Ligand.	type tetraoxime	117-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-69
29614741-1	2018	[Co2(L)Ce(OAc)3(CH3CH2OH)] 1.5CH3OH 0.5CH2Cl2, a heterotrinuclear Co(II)-Ce(III) bis(salamo)-type complex with a symmetric bi(salamo)-type ligand H4L and an acyclic naphthalenediol moiety, was designed, synthesized and characterized by elemental analyses, FT-IR, UV-Vis and fluorescence spectroscopy and X-ray crystallography.	co2(l)ce(oac)3(ch3ch2oh)] 1.5ch3oh 0.5ch2cl2	1-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-72
29614741-1	2018	[Co2(L)Ce(OAc)3(CH3CH2OH)] 1.5CH3OH 0.5CH2Cl2, a heterotrinuclear Co(II)-Ce(III) bis(salamo)-type complex with a symmetric bi(salamo)-type ligand H4L and an acyclic naphthalenediol moiety, was designed, synthesized and characterized by elemental analyses, FT-IR, UV-Vis and fluorescence spectroscopy and X-ray crystallography.	bis(salamo)	81-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-72
29614741-3	2018	Two Co(II) atoms located in the N2O2 coordination spheres, are both hexacoordinated, with slightly distorted octahedral geometries.	dioxohydrazine	32-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
29614741-5	2018	In addition, supramolecular interactions exist in the Co(II)-Ce(III) complex.	ce(iii)	61-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-60
29492489-2	2018	With the objective of increasing the selectivity for COX-2, we introduced a chlorine substituent in position 3, 4, 5, or 6 of the ASS moiety, respectively.	Chlorine	76-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-58
29517777-0	2018	Synthesis of a new series of Ni(ii), Cu(ii), Co(ii) and Pd(ii) complexes with an ONS donor Schiff base: crystal structure, DFT study and catalytic investigation of palladium and nickel complexes towards deacylative sulfenylation of active methylenes and regioselective 3-sulfenylation of indoles via thiouronium salt formation.	Schiff Bases	91-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-34
29517777-0	2018	Synthesis of a new series of Ni(ii), Cu(ii), Co(ii) and Pd(ii) complexes with an ONS donor Schiff base: crystal structure, DFT study and catalytic investigation of palladium and nickel complexes towards deacylative sulfenylation of active methylenes and regioselective 3-sulfenylation of indoles via thiouronium salt formation.	Schiff Bases	91-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-42
29517777-1	2018	A series of Ni(ii), Cu(ii), Co(ii), and Pd(ii) complexes have been synthesized with a chelating Schiff base ligand coordinated to a metal center with ONS donor atoms.	Schiff Bases	96-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-34
29517777-0	2018	Synthesis of a new series of Ni(ii), Cu(ii), Co(ii) and Pd(ii) complexes with an ONS donor Schiff base: crystal structure, DFT study and catalytic investigation of palladium and nickel complexes towards deacylative sulfenylation of active methylenes and regioselective 3-sulfenylation of indoles via thiouronium salt formation.	Schiff Bases	91-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-51
29517777-5	2018	The synthesized Pd(ii) and Ni(ii) complexes as catalysts have been investigated in the C-S cross-coupling of indoles and active methylenes.	Carbon	87-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-21
29517777-5	2018	The synthesized Pd(ii) and Ni(ii) complexes as catalysts have been investigated in the C-S cross-coupling of indoles and active methylenes.	Carbon	87-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-32
29517777-0	2018	Synthesis of a new series of Ni(ii), Cu(ii), Co(ii) and Pd(ii) complexes with an ONS donor Schiff base: crystal structure, DFT study and catalytic investigation of palladium and nickel complexes towards deacylative sulfenylation of active methylenes and regioselective 3-sulfenylation of indoles via thiouronium salt formation.	Schiff Bases	91-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-42
29517777-5	2018	The synthesized Pd(ii) and Ni(ii) complexes as catalysts have been investigated in the C-S cross-coupling of indoles and active methylenes.	Sulfur	89-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-21
29517777-0	2018	Synthesis of a new series of Ni(ii), Cu(ii), Co(ii) and Pd(ii) complexes with an ONS donor Schiff base: crystal structure, DFT study and catalytic investigation of palladium and nickel complexes towards deacylative sulfenylation of active methylenes and regioselective 3-sulfenylation of indoles via thiouronium salt formation.	Palladium	164-173	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-34
29517777-5	2018	The synthesized Pd(ii) and Ni(ii) complexes as catalysts have been investigated in the C-S cross-coupling of indoles and active methylenes.	Sulfur	89-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-32
29517777-0	2018	Synthesis of a new series of Ni(ii), Cu(ii), Co(ii) and Pd(ii) complexes with an ONS donor Schiff base: crystal structure, DFT study and catalytic investigation of palladium and nickel complexes towards deacylative sulfenylation of active methylenes and regioselective 3-sulfenylation of indoles via thiouronium salt formation.	Palladium	164-173	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-42
29517777-5	2018	The synthesized Pd(ii) and Ni(ii) complexes as catalysts have been investigated in the C-S cross-coupling of indoles and active methylenes.	Indoles	109-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-21
29517777-5	2018	The synthesized Pd(ii) and Ni(ii) complexes as catalysts have been investigated in the C-S cross-coupling of indoles and active methylenes.	Indoles	109-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-32
29517777-0	2018	Synthesis of a new series of Ni(ii), Cu(ii), Co(ii) and Pd(ii) complexes with an ONS donor Schiff base: crystal structure, DFT study and catalytic investigation of palladium and nickel complexes towards deacylative sulfenylation of active methylenes and regioselective 3-sulfenylation of indoles via thiouronium salt formation.	Palladium	164-173	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-51
29517777-0	2018	Synthesis of a new series of Ni(ii), Cu(ii), Co(ii) and Pd(ii) complexes with an ONS donor Schiff base: crystal structure, DFT study and catalytic investigation of palladium and nickel complexes towards deacylative sulfenylation of active methylenes and regioselective 3-sulfenylation of indoles via thiouronium salt formation.	Palladium	164-173	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-42
29517777-0	2018	Synthesis of a new series of Ni(ii), Cu(ii), Co(ii) and Pd(ii) complexes with an ONS donor Schiff base: crystal structure, DFT study and catalytic investigation of palladium and nickel complexes towards deacylative sulfenylation of active methylenes and regioselective 3-sulfenylation of indoles via thiouronium salt formation.	Nickel	178-184	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-34
29517777-0	2018	Synthesis of a new series of Ni(ii), Cu(ii), Co(ii) and Pd(ii) complexes with an ONS donor Schiff base: crystal structure, DFT study and catalytic investigation of palladium and nickel complexes towards deacylative sulfenylation of active methylenes and regioselective 3-sulfenylation of indoles via thiouronium salt formation.	Nickel	178-184	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-42
29517777-0	2018	Synthesis of a new series of Ni(ii), Cu(ii), Co(ii) and Pd(ii) complexes with an ONS donor Schiff base: crystal structure, DFT study and catalytic investigation of palladium and nickel complexes towards deacylative sulfenylation of active methylenes and regioselective 3-sulfenylation of indoles via thiouronium salt formation.	Nickel	178-184	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-42
29517777-0	2018	Synthesis of a new series of Ni(ii), Cu(ii), Co(ii) and Pd(ii) complexes with an ONS donor Schiff base: crystal structure, DFT study and catalytic investigation of palladium and nickel complexes towards deacylative sulfenylation of active methylenes and regioselective 3-sulfenylation of indoles via thiouronium salt formation.	Indoles	288-295	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-34
29517777-0	2018	Synthesis of a new series of Ni(ii), Cu(ii), Co(ii) and Pd(ii) complexes with an ONS donor Schiff base: crystal structure, DFT study and catalytic investigation of palladium and nickel complexes towards deacylative sulfenylation of active methylenes and regioselective 3-sulfenylation of indoles via thiouronium salt formation.	Indoles	288-295	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-42
29517777-0	2018	Synthesis of a new series of Ni(ii), Cu(ii), Co(ii) and Pd(ii) complexes with an ONS donor Schiff base: crystal structure, DFT study and catalytic investigation of palladium and nickel complexes towards deacylative sulfenylation of active methylenes and regioselective 3-sulfenylation of indoles via thiouronium salt formation.	Indoles	288-295	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-42
29517777-0	2018	Synthesis of a new series of Ni(ii), Cu(ii), Co(ii) and Pd(ii) complexes with an ONS donor Schiff base: crystal structure, DFT study and catalytic investigation of palladium and nickel complexes towards deacylative sulfenylation of active methylenes and regioselective 3-sulfenylation of indoles via thiouronium salt formation.	thiouronium salt	300-316	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-34
29517777-0	2018	Synthesis of a new series of Ni(ii), Cu(ii), Co(ii) and Pd(ii) complexes with an ONS donor Schiff base: crystal structure, DFT study and catalytic investigation of palladium and nickel complexes towards deacylative sulfenylation of active methylenes and regioselective 3-sulfenylation of indoles via thiouronium salt formation.	thiouronium salt	300-316	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-42
29517777-0	2018	Synthesis of a new series of Ni(ii), Cu(ii), Co(ii) and Pd(ii) complexes with an ONS donor Schiff base: crystal structure, DFT study and catalytic investigation of palladium and nickel complexes towards deacylative sulfenylation of active methylenes and regioselective 3-sulfenylation of indoles via thiouronium salt formation.	thiouronium salt	300-316	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-42
29713361-4	2018	AGNE reduced histamine secretion, production of proinflammatory cytokines including interleukin- (IL-) 1beta, IL-4, IL-6, IL-8, and IL-10, and expression of cyclooxygenase- (COX-) 2 in HMC-1 cells.	agne	0-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	157-181
29556059-0	2018	Molecular Insights into the Interaction of RONS and Thieno[3,2-c]pyran Analogs with SIRT6/COX-2: A Molecular Dynamics Study.	rice bran saccharide	43-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-95
29556059-0	2018	Molecular Insights into the Interaction of RONS and Thieno[3,2-c]pyran Analogs with SIRT6/COX-2: A Molecular Dynamics Study.	thieno[3,2-c]pyran	52-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-95
29556059-3	2018	Herein, we studied the interaction of thieno[3,2-c]pyran analogs and RONS species with SIRT6 and COX-2 through the use of molecular docking and molecular dynamic simulations.	thieno[3,2-c]pyran	38-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
29562646-2	2018	Based on the fact that cyclooxygenase isoenzymes (COX-1, COX-2) are responsible for the production of prostaglandins that play an important role in inflammation, traditional treatment approaches include administration of non-steroidal anti-inflammatory drugs (NSAIDs), which act as selective or non-selective COX inhibitors.	Prostaglandins	102-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-62
29562646-6	2018	This review focuses on the biological activity of several thiazole and thiazolidinone derivatives as COX-1/COX-2 and LOX inhibitors.	Thiazoles	58-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-112
29562646-6	2018	This review focuses on the biological activity of several thiazole and thiazolidinone derivatives as COX-1/COX-2 and LOX inhibitors.	thiazolidinone	71-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-112
29593389-5	2018	The expression of key proteins such as AKT and COX-2 was suppressed, which suggests that doxorubicin and celecoxib synergistically inhibit multiple key signaling pathways.	Doxorubicin	89-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
29593389-5	2018	The expression of key proteins such as AKT and COX-2 was suppressed, which suggests that doxorubicin and celecoxib synergistically inhibit multiple key signaling pathways.	Celecoxib	105-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
29451291-1	2018	In this work, we demonstrate the synthesis and application of a novel CoII-based metal-organic framework {[Co2(Dcpp)(Bpe)0.5 (H2O)(mu2-H2O)] (Bpe)0.5}n (CoII-MOF, H4Dcpp = 4,5-bis(4"-carboxylphenyl)-phthalic acid, Bpe = 1,2-bis(4-pyridyl)ethane) as an electrochemical sensor for glucose detection.	Metals	81-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	153-157
29451291-1	2018	In this work, we demonstrate the synthesis and application of a novel CoII-based metal-organic framework {[Co2(Dcpp)(Bpe)0.5 (H2O)(mu2-H2O)] (Bpe)0.5}n (CoII-MOF, H4Dcpp = 4,5-bis(4"-carboxylphenyl)-phthalic acid, Bpe = 1,2-bis(4-pyridyl)ethane) as an electrochemical sensor for glucose detection.	Water	126-129	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-74
29451291-1	2018	In this work, we demonstrate the synthesis and application of a novel CoII-based metal-organic framework {[Co2(Dcpp)(Bpe)0.5 (H2O)(mu2-H2O)] (Bpe)0.5}n (CoII-MOF, H4Dcpp = 4,5-bis(4"-carboxylphenyl)-phthalic acid, Bpe = 1,2-bis(4-pyridyl)ethane) as an electrochemical sensor for glucose detection.	mu2-h2o)	131-139	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-74
29451291-1	2018	In this work, we demonstrate the synthesis and application of a novel CoII-based metal-organic framework {[Co2(Dcpp)(Bpe)0.5 (H2O)(mu2-H2O)] (Bpe)0.5}n (CoII-MOF, H4Dcpp = 4,5-bis(4"-carboxylphenyl)-phthalic acid, Bpe = 1,2-bis(4-pyridyl)ethane) as an electrochemical sensor for glucose detection.	h4dcpp	163-169	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-74
29451291-1	2018	In this work, we demonstrate the synthesis and application of a novel CoII-based metal-organic framework {[Co2(Dcpp)(Bpe)0.5 (H2O)(mu2-H2O)] (Bpe)0.5}n (CoII-MOF, H4Dcpp = 4,5-bis(4"-carboxylphenyl)-phthalic acid, Bpe = 1,2-bis(4-pyridyl)ethane) as an electrochemical sensor for glucose detection.	4,5-bis(4"-carboxylphenyl)-phthalic acid	172-212	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-74
29451291-1	2018	In this work, we demonstrate the synthesis and application of a novel CoII-based metal-organic framework {[Co2(Dcpp)(Bpe)0.5 (H2O)(mu2-H2O)] (Bpe)0.5}n (CoII-MOF, H4Dcpp = 4,5-bis(4"-carboxylphenyl)-phthalic acid, Bpe = 1,2-bis(4-pyridyl)ethane) as an electrochemical sensor for glucose detection.	1,2-Bis(4-pyridyl)ethane	220-244	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-74
29451291-1	2018	In this work, we demonstrate the synthesis and application of a novel CoII-based metal-organic framework {[Co2(Dcpp)(Bpe)0.5 (H2O)(mu2-H2O)] (Bpe)0.5}n (CoII-MOF, H4Dcpp = 4,5-bis(4"-carboxylphenyl)-phthalic acid, Bpe = 1,2-bis(4-pyridyl)ethane) as an electrochemical sensor for glucose detection.	Glucose	279-286	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-74
29451291-2	2018	Single-crystal X-ray diffraction analysis shows that the CoII-MOF has a two-dimensional (2D) bilayer structure composed of Co2 units and Dcpp4- ligands.	dcpp4	137-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-61
29451291-4	2018	The CoII-MOF modified glassy carbon electrode (GCE) shows good electrocatalytic activity towards glucose oxidation.	Carbon	29-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-8
29451291-4	2018	The CoII-MOF modified glassy carbon electrode (GCE) shows good electrocatalytic activity towards glucose oxidation.	Glucose	97-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-8
29451291-5	2018	To further improve the catalytic activity of the electrode, a new composite of CoII-MOF/acetylene black (CoII-MOF/Acb) was constructed.	Acetylene	88-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-109
29451291-6	2018	The CoII-MOF/Acb modified electrode exhibits enhanced sensing behavior for glucose detection.	Glucose	75-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-8
29568008-0	2018	Voriconazole-induced photocarcinogenesis is promoted by aryl hydrocarbon receptor-dependent COX-2 upregulation.	Voriconazole	0-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-97
29443339-5	2018	Furthermore, the isostructural ZnII analogue (5) has been prepared to examine the influence of dipolar interactions between adjacent CoII centres and magnetic dilution experiments were performed.	Zinc	31-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	133-137
29451291-0	2018	Enhanced glucose sensing based on a novel composite CoII-MOF/Acb modified electrode.	Glucose	9-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-56
29451291-1	2018	In this work, we demonstrate the synthesis and application of a novel CoII-based metal-organic framework {[Co2(Dcpp)(Bpe)0.5 (H2O)(mu2-H2O)] (Bpe)0.5}n (CoII-MOF, H4Dcpp = 4,5-bis(4"-carboxylphenyl)-phthalic acid, Bpe = 1,2-bis(4-pyridyl)ethane) as an electrochemical sensor for glucose detection.	Metals	81-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-74
30966346-1	2018	Herein, we report the preparation of chiral, one-dimensional coordination polymers based on trinuclear paddlewheel helices [M3(dpa)4]2+ (M = Co(II) and Ni(II); dpa = the anion of 2,2"-dipyridylamine).	Polymers	74-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	141-147
29780487-1	2018	The Cr7Co ring represents a model system to understand how the anisotropy of a CoII ion is transferred to the effective anisotropy of a polymetallic cluster by strong exchange interactions.	cr7co	4-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-83
31458563-10	2018	The calculations show that a small part of the inorganic spins are delocalized over the oxygens from hfac {~0.03 for Co(II) and ~0.015 for Mn(II)}, whereas a more significant fraction {~0.24 for Mn(II) and ~0.13 for Co(II)} of delocalized spins from the metal ion is transferred to the coordinated oxygen atom(s) of nitronyl nitroxide.	Oxygen	88-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-123
31458563-10	2018	The calculations show that a small part of the inorganic spins are delocalized over the oxygens from hfac {~0.03 for Co(II) and ~0.015 for Mn(II)}, whereas a more significant fraction {~0.24 for Mn(II) and ~0.13 for Co(II)} of delocalized spins from the metal ion is transferred to the coordinated oxygen atom(s) of nitronyl nitroxide.	Oxygen	88-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-123
30288211-0	2018	Correction: Novel valdecoxib derivatives by ruthenium(ii)-promoted 1,3-dipolar cycloaddition of nitrile oxides with alkynes - synthesis and COX-2 inhibition activity.	valdecoxib	18-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-145
30288211-0	2018	Correction: Novel valdecoxib derivatives by ruthenium(ii)-promoted 1,3-dipolar cycloaddition of nitrile oxides with alkynes - synthesis and COX-2 inhibition activity.	Ruthenium(II)	44-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-145
30288211-0	2018	Correction: Novel valdecoxib derivatives by ruthenium(ii)-promoted 1,3-dipolar cycloaddition of nitrile oxides with alkynes - synthesis and COX-2 inhibition activity.	nitrile oxides	96-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-145
29515134-7	2018	COX-2 siRNA and celecoxib were used to inhibit COX-2.	Celecoxib	16-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
28803844-0	2018	The ATF6alpha arm of the Unfolded Protein Response mediates replicative senescence in human fibroblasts through a COX2/prostaglandin E2 intracrine pathway.	Dinoprostone	119-135	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-118
29515134-9	2018	In conclusion, celecoxib partially restores autophagic flux via downregulation of COX-2 and alleviates steatosis in vitro and in vivo.	Celecoxib	15-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
28818745-6	2018	CONCLUSIONS: Extended research is necessary for the development of these novel compounds targeting the eicosanoid pathway, by increasing the levels of anti-inflammatory eicosanoids (PGD2,15dPGJ2), by inhibiting the production of pro-inflammatory eicosanoids (PGE2, LTB4, PGI2) involved in rheumatoid arthritis or also by developing dual compounds displaying both the COX-2 inhibitor/TP antagonist activity within a single compound.	Eicosanoids	103-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	367-372
29356224-4	2018	Our results demonstrated that sauchinone significantly attenuated NO and PGE2 production, as well as inhibited iNOS and COX-2 expression in IL-1beta-stimulated OA chondrocytes.	sauchinone	30-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-125
29562094-4	2018	At pH 9.0, the affinity of both generations towards heavy metal ions was also observed in the decreasing order of Zn(II) &gt; Co(II) &gt; Ni(II) &gt; Cu(II) &gt; Cd(II).	Metals	58-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-132
29562094-4	2018	At pH 9.0, the affinity of both generations towards heavy metal ions was also observed in the decreasing order of Zn(II) &gt; Co(II) &gt; Ni(II) &gt; Cu(II) &gt; Cd(II).	Zinc	114-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-132
29562094-4	2018	At pH 9.0, the affinity of both generations towards heavy metal ions was also observed in the decreasing order of Zn(II) &gt; Co(II) &gt; Ni(II) &gt; Cu(II) &gt; Cd(II).	Cadmium	162-164	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-132
29378219-3	2018	Biological activity of all the new meroterpenoids against COX-2 was evaluated in vitro, only ganotheaecoloid J (11) was found to have COX-2 inhibitory activity with IC50 value of 9.96muM.	Ganotheaecoloid J	93-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-139
29318480-4	2018	The results indicated that rosmarinic acid reduced the expression of CD11b, a marker of microglia and macrophages, in the brain and dramatically inhibited the levels of inflammatory cytokines and mediators, such as TNFalpha, IL-6, IL-1beta, COX-2, and iNOS, in a dose-dependent manner both in vitro and in vivo.	rosmarinic acid	27-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	241-246
29073723-0	2018	BMP9/COX-2 axial mediates high phosphate-induced calcification in vascular smooth muscle cells via Wnt/beta-catenin pathway.	Phosphates	31-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	5-10
29073723-7	2018	High phosphate and over-expression of BMP9 increases the level of COX-2.	Phosphates	5-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-71
29073723-8	2018	Over-expression of COX-2 enhances the inhibitory effect of BMP9 on alpha-SAM and increases the level of OPN and OCN induced by BMP9.	alpha-sam	67-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-24
28803844-4	2018	Herein, we investigated whether the up-regulation of the COX2 (PTGS2) limiting enzyme in the prostaglandin biosynthesis pathway, known to mediate cellular senescence in normal human fibroblasts, could be controlled by the UPR sensors ATF6alpha, IRE1alpha and PERK.	Prostaglandins	93-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-61
29353005-0	2018	Cryptotanshinone inhibits prostaglandin E2 production and COX-2 expression via suppression of TLR4/NF-kappaB signaling pathway in LPS-stimulated Caco-2 cells.	cryptotanshinone	0-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
28803844-9	2018	Taken together, our results support a critical role of ATF6alpha in the establishment and maintenance of cellular senescence in normal human fibroblasts via the up-regulation of a COX2/PGE2 intracrine pathway.	Dinoprostone	185-189	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	180-184
29353005-2	2018	The aim of this study was to evaluate the effect of CTN on prostaglandin E2 and COX-2 production in LPS-stimulated human intestinal cells (Caco-2 cells).	Cytidine	52-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-85
29353005-7	2018	The results showed that CTN dose-dependently inhibited the expression of COX-2 both in mRNA and protein levels, resulting in a decreased production of PGE2.	Cytidine	24-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-78
29353005-7	2018	The results showed that CTN dose-dependently inhibited the expression of COX-2 both in mRNA and protein levels, resulting in a decreased production of PGE2.	Dinoprostone	151-155	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-78
29197622-4	2018	Mechanistic study showed that dioscin significantly up-regulated the expression levels of Sirt3, SOD2, and then suppressed inflammation by decreasing the expression levels of NF-kB, HMGB1, c-Jun, c-Fos, COX2, TNF-alpha, IL-1beta and IL-6.	dioscin	30-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	203-207
29257341-3	2018	The results indicated that carvacrol inhibited nitric oxide (NO) and prostaglandin E2 (PGE2) production, and decreased the expression of inducible NO synthase (iNOS) and cyclooxygenase (COX-2).	carvacrol	27-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	186-191
29257341-6	2018	In conclusion, the present results demonstrated that carvacrol was able to inhibit IL-1beta-induced NO and PGE2 production, as well as iNOS, COX-2 and MMPs expression in human chondrocytes by suppressing the activation of NF-kappaB signaling pathway.	carvacrol	53-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	141-146
29338479-0	2018	Graphene oxide regulates cox2 in human embryonic kidney 293T cells via epigenetic mechanisms: dynamic chromosomal interactions.	graphene oxide	0-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-29
29407982-1	2018	In this work, a serie of cyclocoumarol derivatives was designed, synthesized, characterized and studied for their potentialities as selective inhibitors of COX-2.	cyclocumarol	25-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	156-161
29407982-4	2018	Docking studies revealed the capacity of this compound to occupy the selective COX-2 cavity establishing additional hydrogen bonds between the oxygen of the methoxy group and the His90 and Arg513 of the binding site of the enzyme.	Hydrogen	116-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-84
29407982-4	2018	Docking studies revealed the capacity of this compound to occupy the selective COX-2 cavity establishing additional hydrogen bonds between the oxygen of the methoxy group and the His90 and Arg513 of the binding site of the enzyme.	Oxygen	143-149	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-84
29412653-7	2018	Amide pendents deprotonate at high pH (&gt;8), and the water ligands of the Co(II) complexes are not deprotonated at neutral pH.	amide pendents deprotonate	0-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-82
29412653-0	2018	Inner-Sphere and Outer-Sphere Water Interactions in Co(II) paraCEST Agents.	Water	30-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-57
30966264-0	2018	Two New Three-Dimensional Pillared-Layer Co(II) and Cu(II) Frameworks Involving a [M2(EO-N3)2] Motif from a Semi-Flexible N-Donor Ligand, 5,5"-Bipyrimidin: Syntheses, Structures and Magnetic Properties.	(eo-n3)2	85-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-47
30966264-0	2018	Two New Three-Dimensional Pillared-Layer Co(II) and Cu(II) Frameworks Involving a [M2(EO-N3)2] Motif from a Semi-Flexible N-Donor Ligand, 5,5"-Bipyrimidin: Syntheses, Structures and Magnetic Properties.	Nitrogen	4-5	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-47
30966264-0	2018	Two New Three-Dimensional Pillared-Layer Co(II) and Cu(II) Frameworks Involving a [M2(EO-N3)2] Motif from a Semi-Flexible N-Donor Ligand, 5,5"-Bipyrimidin: Syntheses, Structures and Magnetic Properties.	5,5"-bipyrimidin	138-154	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-47
30966264-1	2018	Two new three-dimensional (3D) Co(II)- and Cu(II)-azido frameworks, [Co2(N3)4(bpym)2]n (1) and [Cu2(N3)4(bpym)]n (2), were successfully synthesized by introducing a semi-flexible N-donor ligand, 5,5"-bipyrimidin (bpym), with different bridging modes and orientations.	bpym)	78-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-37
30966264-1	2018	Two new three-dimensional (3D) Co(II)- and Cu(II)-azido frameworks, [Co2(N3)4(bpym)2]n (1) and [Cu2(N3)4(bpym)]n (2), were successfully synthesized by introducing a semi-flexible N-donor ligand, 5,5"-bipyrimidin (bpym), with different bridging modes and orientations.	2,2'-Bipyrimidine	78-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-37
30966264-4	2018	In Compound 1, the bpym ligands show trans mu2-bridging mode and the role as pillars to connect the Co(II)-azido layers, composed of [Co2(EO-N3)2] motifs and single end-to-end (EE) azido bridges, to a 3D network with BN topology.	3',5-diazido-2',3'-dideoxyuridine	107-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-106
29412653-2	2018	The first examples of Co(II) paraCEST agents with bound water ligands are presented here.	Water	56-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-27
29412653-7	2018	Amide pendents deprotonate at high pH (&gt;8), and the water ligands of the Co(II) complexes are not deprotonated at neutral pH.	Water	55-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-82
29412653-3	2018	Four Co(II) macrocyclic complexes based on 1,4,7-triazacyclononane and containing either pendent alcohol or pendent amide groups were prepared.	1,4,7-triazacyclononane	43-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	5-11
29511436-0	2018	Dihydroartemisinin inhibits indoxyl sulfate (IS)-promoted cell cycle progression in mesangial cells by targeting COX-2/mPGES-1/PGE2 cascade.	artenimol	0-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-118
29412653-3	2018	Four Co(II) macrocyclic complexes based on 1,4,7-triazacyclononane and containing either pendent alcohol or pendent amide groups were prepared.	pendent alcohol	89-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	5-11
29412653-3	2018	Four Co(II) macrocyclic complexes based on 1,4,7-triazacyclononane and containing either pendent alcohol or pendent amide groups were prepared.	Amides	116-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	5-11
29420045-0	2018	Thiocarbamate-Directed Tandem Olefination-Intramolecular Sulfuration of Two Ortho C-H Bonds: Application to Synthesis of a COX-2 Inhibitor.	Thiocarbamates	0-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-128
29420045-4	2018	This reaction provides a concise route to the S,O,C multisubstituted benzene skeleton which could be successfully applied for the synthesis of a COX-2 inhibitor.	Benzene	69-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-150
29511436-0	2018	Dihydroartemisinin inhibits indoxyl sulfate (IS)-promoted cell cycle progression in mesangial cells by targeting COX-2/mPGES-1/PGE2 cascade.	Indican	28-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-118
29511436-0	2018	Dihydroartemisinin inhibits indoxyl sulfate (IS)-promoted cell cycle progression in mesangial cells by targeting COX-2/mPGES-1/PGE2 cascade.	Indican	45-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-118
29511436-5	2018	Interestingly, DHA also inactivated the COX-2/mPGES-1/PGE2 cascade which has been shown to play a critical role in promoting the mesangial cell cycle progression by our previous studies.	artenimol	15-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
29511436-5	2018	Interestingly, DHA also inactivated the COX-2/mPGES-1/PGE2 cascade which has been shown to play a critical role in promoting the mesangial cell cycle progression by our previous studies.	Dinoprostone	54-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
29511436-7	2018	As expected, DHA treatment significantly retarded IS-induced cell cycle progression and inhibited the activation of COX-2/mPGES-1/PGE2 cascade induced by IS.	artenimol	13-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-121
29511436-8	2018	In summary, these data indicated that DHA inhibited the cell cycle progression in glomerular mesangial cells under normal condition or IS challenge possibly through the inhibition of COX-2/mPGES-1/PGE2 cascade, suggesting a potential of DHA in treating glomerular diseases with mesangial cell proliferation.	artenimol	38-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	183-188
29334459-6	2018	Lennard-Jones parameters for the cobalt center in the Co(II) and Co(I) states were optimized using a helium atom probe, and partial atomic charges were obtained with a combination of natural population analysis (NPA) and restrained electrostatic potential (RESP) fitting approaches.	Cobalt	33-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-60
30108944-0	2018	Novel valdecoxib derivatives by ruthenium(ii)-promoted 1,3-dipolar cycloaddition of nitrile oxides with alkynes - synthesis and COX-2 inhibition activity.	valdecoxib	6-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	128-133
30108944-0	2018	Novel valdecoxib derivatives by ruthenium(ii)-promoted 1,3-dipolar cycloaddition of nitrile oxides with alkynes - synthesis and COX-2 inhibition activity.	Ruthenium(II)	32-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	128-133
30108944-0	2018	Novel valdecoxib derivatives by ruthenium(ii)-promoted 1,3-dipolar cycloaddition of nitrile oxides with alkynes - synthesis and COX-2 inhibition activity.	nitrile oxides	84-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	128-133
30108944-3	2018	The new the 3,4-diaryl-substituted isoxazoles possessing a small substituent (H and Me) displayed high COX-2 inhibition affinity (IC50 = 0.042-0.073 muM) and excellent selectivity (COX-2 SI &gt; 2000).	3,4-diaryl-substituted isoxazoles	12-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-108
30108944-3	2018	The new the 3,4-diaryl-substituted isoxazoles possessing a small substituent (H and Me) displayed high COX-2 inhibition affinity (IC50 = 0.042-0.073 muM) and excellent selectivity (COX-2 SI &gt; 2000).	3,4-diaryl-substituted isoxazoles	12-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	181-186
30108944-5	2018	The introduction of a 4-fluorophenyl substituent resulted in retained high COX-2 affinity, making these compounds together with the feasible one step reaction promising candidates for the development of fluorine-18 labelled radiotracers.	Fluorine-18	203-214	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
29483877-10	2018	There is a decrease in the percentage of AA, associated with an increase of PLA2, COX2/TXA2R, CYP450 4A, and 5-LOX which leads to a greater synthesis of PGE2 than of 6-keto-PGF1alpha, thus contributing to the formation of the aortic aneurysm.	6-Ketoprostaglandin F1 alpha	166-182	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-86
29483877-10	2018	There is a decrease in the percentage of AA, associated with an increase of PLA2, COX2/TXA2R, CYP450 4A, and 5-LOX which leads to a greater synthesis of PGE2 than of 6-keto-PGF1alpha, thus contributing to the formation of the aortic aneurysm.	Dinoprostone	153-157	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-86
29091730-4	2018	Conversely, 1H NMR studies revealed that 2 equiv of AMA remove 2 equiv of Co(II) from Co(II)-substituted NDM-1, VIM-2, and IMP-7 when the MBL/AMA are at millimolar concentrations.	Hydrogen	12-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-80
29568391-7	2018	In MCF-7 cells, GlyPro increased collagen biosynthesis, concentration of proline and expression of caspase-3, cleaved caspases -3 and -9, iNOS, NF-kappaB, COX-2 and AMPKbeta.	glycylproline	16-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	155-160
29281763-2	2018	The chlorophosphine CoII complex (PPCl P)CoCl2 (2) can be generated through coordination of the chlorophosphine ligand (PPCl P, 1) to CoCl2 .	Chlorophosphorane	4-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-24
29302958-8	2018	Finally, we demonstrate that doping ZIF-8 by Co(II) enhances the photodegradation of methylene blue dye under visible light irradiation in the absence of hydrogen peroxide.	2-Methylimidazole zinc salt	36-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-51
29302958-8	2018	Finally, we demonstrate that doping ZIF-8 by Co(II) enhances the photodegradation of methylene blue dye under visible light irradiation in the absence of hydrogen peroxide.	Methylene Blue	85-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-51
29178431-3	2018	Metal ions such as cobalt(II), iron(III), platinum(IV) and nickel(II) are found to partition preferentially to one of the phases of the acidic aqueous biphasic system and it is here shown that it successfully allows the difficult separation of CoII from NiII , here studied at 24 and 50  C.	Metals	0-5	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	244-248
29178431-3	2018	Metal ions such as cobalt(II), iron(III), platinum(IV) and nickel(II) are found to partition preferentially to one of the phases of the acidic aqueous biphasic system and it is here shown that it successfully allows the difficult separation of CoII from NiII , here studied at 24 and 50  C.	Cobalt(2+)	19-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	244-248
29178431-3	2018	Metal ions such as cobalt(II), iron(III), platinum(IV) and nickel(II) are found to partition preferentially to one of the phases of the acidic aqueous biphasic system and it is here shown that it successfully allows the difficult separation of CoII from NiII , here studied at 24 and 50  C.	Iron	31-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	244-248
29178431-3	2018	Metal ions such as cobalt(II), iron(III), platinum(IV) and nickel(II) are found to partition preferentially to one of the phases of the acidic aqueous biphasic system and it is here shown that it successfully allows the difficult separation of CoII from NiII , here studied at 24 and 50  C.	Platinum	42-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	244-248
29178431-3	2018	Metal ions such as cobalt(II), iron(III), platinum(IV) and nickel(II) are found to partition preferentially to one of the phases of the acidic aqueous biphasic system and it is here shown that it successfully allows the difficult separation of CoII from NiII , here studied at 24 and 50  C.	Nickel	59-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	244-248
29281763-2	2018	The chlorophosphine CoII complex (PPCl P)CoCl2 (2) can be generated through coordination of the chlorophosphine ligand (PPCl P, 1) to CoCl2 .	ppcl p	34-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-24
29281763-2	2018	The chlorophosphine CoII complex (PPCl P)CoCl2 (2) can be generated through coordination of the chlorophosphine ligand (PPCl P, 1) to CoCl2 .	cobaltous chloride	41-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-24
29182950-0	2018	Design, synthesis, anti-inflammatory antitumor activities, molecular modeling and molecular dynamics simulations of potential naprosyn  analogs as COX-1 and/or COX-2 inhibitors.	Naproxen	126-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	160-165
29363959-6	2018	Chemically or electrochemically generated Co(I) porphyrins are known to be highly reactive in solutions containing alkyl or aryl halides, and this property was utilized to in situ generate a new series of methyl carbon-bonded cobalt(III) porphyrins with the same pi-extending or highly electron-withdrawing substituents as the initial Co(II) derivatives.	Carbon	212-218	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	335-341
29368926-2	2018	Macrocyclic tetrapyridyl ligands (pyrphyrins) and their CoII complexes emerged in this context as a highly efficient class of H2 evolution catalysts.	pyrphyrins	34-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-60
29368926-2	2018	Macrocyclic tetrapyridyl ligands (pyrphyrins) and their CoII complexes emerged in this context as a highly efficient class of H2 evolution catalysts.	Hydrogen	126-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-60
29568365-6	2018	Moreover, amiodarone suppressed miR-224 and increased its target COX-2 expression.	Amiodarone	10-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-70
29154948-2	2018	Upon synthesis, COX2 engages with COX20 in the inner mitochondrial membrane, a scaffold protein that recruits metallochaperones for copper delivery to the CuA-Site of COX2.	Copper	132-138	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-20
29154948-2	2018	Upon synthesis, COX2 engages with COX20 in the inner mitochondrial membrane, a scaffold protein that recruits metallochaperones for copper delivery to the CuA-Site of COX2.	Copper	132-138	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-38
29182950-4	2018	In this study, novel and successfully synthesized naproxen-derivatives indicated powerful anti-inflammatory properties as potent of COX-1 and/or COX-2 inhibitors are reported.	Naproxen	50-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-150
29085960-6	2018	Interestingly, podocyte co-incubated with TGF-beta1, high glucose and/or PGE2 showed strong increase in p38 MAPK and AKT phosphorylation as well as COX- 2 protein expression levels.	Glucose	58-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	148-154
29117589-6	2018	Additionally, long-term exposure of MC-LR at low concentration remarkably promoted the expression of NF-kappaB p65, COX-2, iNOS, TNF-alpha, IL-1beta, and IL-6 in the cells, suggesting that long-term MC-LR exposure at low concentration can induce inflammatory reaction to HepG2 cells, which might account for MC-induced human hepatitis.	cyanoginosin LR	36-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-121
29117589-6	2018	Additionally, long-term exposure of MC-LR at low concentration remarkably promoted the expression of NF-kappaB p65, COX-2, iNOS, TNF-alpha, IL-1beta, and IL-6 in the cells, suggesting that long-term MC-LR exposure at low concentration can induce inflammatory reaction to HepG2 cells, which might account for MC-induced human hepatitis.	Methylcholanthrene	36-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-121
29242151-0	2018	Resveratrol induces sumoylated COX-2-dependent anti-proliferation in human prostate cancer LNCaP cells.	Resveratrol	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-36
29242151-2	2018	However, resveratrol-induced nuclear accumulation of COX-2 enhances p53-dependent anti-proliferation in different types of cancers.	Resveratrol	9-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-58
29242151-3	2018	Treatment with resveratrol leads to phosphorylation and nuclear translocation of mitogen-activated protein kinase (ERK1/2), and accumulation of nuclear COX-2 to complex with pERK1/2 and p53.	Resveratrol	15-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-157
29242151-5	2018	We investigated the mechanisms by which resveratrol-inducible COX-2 facilitates p53-dependent anti-proliferation in prostate cancer LNCaP cells.	Resveratrol	40-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
29242151-6	2018	Resveratrol treatment caused nuclear accumulation and complexing of ERK1/2, pSer15-p53 and COX-2 which was activated ERK1/2-dependent.	Resveratrol	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-96
29242151-8	2018	Inhibition of nuclear accumulation by the COX-2 specific inhibitor, NS-398, inhibited co-localization of nuclear COX-2 and SUMO-1.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	68-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47
29242151-8	2018	Inhibition of nuclear accumulation by the COX-2 specific inhibitor, NS-398, inhibited co-localization of nuclear COX-2 and SUMO-1.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	68-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-118
29242151-11	2018	In summary, these results demonstrate that inducible COX-2 associates with phosphorylated ERK1/2 to induce the phosphorylation of Ser-15 in p53 and then complexes with p53 and SUMO-1 which binds to p53-responsive pro-apoptotic genes to enhance their expression.	Serine	130-133	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-58
29242151-12	2018	The inhibition of COX-2 expression and activity significantly blocks the pro-apoptotic effect of resveratrol.	Resveratrol	97-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-23
29085960-9	2018	Also, inhibition of phosphatases reversed TGF-beta1-induced COX-2 protein expression either alone or when incubated with high glucose or PGE2.	Glucose	126-133	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-65
29085960-9	2018	Also, inhibition of phosphatases reversed TGF-beta1-induced COX-2 protein expression either alone or when incubated with high glucose or PGE2.	Dinoprostone	137-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-65
29085960-6	2018	Interestingly, podocyte co-incubated with TGF-beta1, high glucose and/or PGE2 showed strong increase in p38 MAPK and AKT phosphorylation as well as COX- 2 protein expression levels.	Dinoprostone	73-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	148-154
29241029-2	2018	COX-2 is the key enzyme generating pleiotropic prostaglandins.	Prostaglandins	47-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
29230527-6	2018	Furthermore, LEFTY2 and the Orai1 blockers 2-APB, MRS-1845, as well as YM-58483, inhibited, whereas the Ca2+ ionophore, ionomycin, strongly upregulated COX2, BMP2 and WNT4 expression in decidualizing HESCs.	2-aminoethoxydiphenyl borate	43-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-156
29230527-6	2018	Furthermore, LEFTY2 and the Orai1 blockers 2-APB, MRS-1845, as well as YM-58483, inhibited, whereas the Ca2+ ionophore, ionomycin, strongly upregulated COX2, BMP2 and WNT4 expression in decidualizing HESCs.	Ionomycin	120-129	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-156
29230527-11	2018	LEFTY2 and the Orai1 blockers 2-APB, MRS-1845, and YM-58483 inhibit COX2, BMP2, and WNT4 expression in endometrial cells.	2-aminoethoxydiphenyl borate	30-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-72
29230527-11	2018	LEFTY2 and the Orai1 blockers 2-APB, MRS-1845, and YM-58483 inhibit COX2, BMP2, and WNT4 expression in endometrial cells.	4-methyl-4'-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)-1,2,3-thiadiazole-5-carboxanilide	51-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-72
29511456-11	2018	Our results demonstrated that expression of IL-6 and COX-2 were remarkably up-regulated in peripheral blood of DMCI patients compared with that in normal control group.	dmci	111-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-58
29511456-15	2018	Our data have implied that altered expression of miR-146b-3p is closely related to the progression and development of DCMI mediating the RAF/P38MAPK/COX-2 signal transduction pathway.	dcmi	118-122	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	149-154
29022246-3	2018	In this study, we investigated the role of endogenous antioxidant alpha-lipoic acid (ALA) as ROSs scavenger in the OLGs loss and myelin degeneration during cuprizone (cup)-induced demyelination in the experimental model of MS. Our results have shown that ALA treatment significantly increased population of mature OLGs (MOG+ cells), as well as decreased oxidative stress (ROSs, COX-2 and PGE2) and apoptosis mediators (caspase-3 and Bax/Bcl2 ratio) in corpus callosum (CC).	Thioctic Acid	85-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	378-383
29308820-3	2018	The S-nitrosylation detection and subsequent kinetic investigations into the arachidonic acid (AA) oxidation of COX enzymes indicate that NO S-nitrosylates both COX-1 and COX-2 in an oxygen-dependent manner, but enhances only the dioxygenase activity of COX-2.	Arachidonic Acid	77-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	171-176
29308820-3	2018	The S-nitrosylation detection and subsequent kinetic investigations into the arachidonic acid (AA) oxidation of COX enzymes indicate that NO S-nitrosylates both COX-1 and COX-2 in an oxygen-dependent manner, but enhances only the dioxygenase activity of COX-2.	Arachidonic Acid	77-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	254-259
29308820-3	2018	The S-nitrosylation detection and subsequent kinetic investigations into the arachidonic acid (AA) oxidation of COX enzymes indicate that NO S-nitrosylates both COX-1 and COX-2 in an oxygen-dependent manner, but enhances only the dioxygenase activity of COX-2.	Oxygen	183-189	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	171-176
29308820-4	2018	The solution viscosity, deuterium kinetic isotope effect (KIE), and oxygen-18 KIE experiments further demonstrate that NO activates COX-2 by altering the protein conformation to stimulate substrate association/product release and by accelerating the rate of hydrogen abstraction from AA by catalytic tyrosine radicals.	Deuterium	24-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-137
29308820-4	2018	The solution viscosity, deuterium kinetic isotope effect (KIE), and oxygen-18 KIE experiments further demonstrate that NO activates COX-2 by altering the protein conformation to stimulate substrate association/product release and by accelerating the rate of hydrogen abstraction from AA by catalytic tyrosine radicals.	Oxygen	68-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-137
29385156-9	2018	CONCLUSIONS: Patients who have OA and T2DM receiving combination COX-2 inhibitors and metformin therapy associated with lower joint replacement surgery rates than those without and this may be attributable to combination therapy much more decrease pro-inflammatory factors associated than those without metformin therapy.	Metformin	303-312	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-70
29308820-4	2018	The solution viscosity, deuterium kinetic isotope effect (KIE), and oxygen-18 KIE experiments further demonstrate that NO activates COX-2 by altering the protein conformation to stimulate substrate association/product release and by accelerating the rate of hydrogen abstraction from AA by catalytic tyrosine radicals.	Hydrogen	258-266	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-137
29308820-4	2018	The solution viscosity, deuterium kinetic isotope effect (KIE), and oxygen-18 KIE experiments further demonstrate that NO activates COX-2 by altering the protein conformation to stimulate substrate association/product release and by accelerating the rate of hydrogen abstraction from AA by catalytic tyrosine radicals.	tyrosine radical	300-317	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-137
29313552-0	2018	Effect of linear and non-linear pseudohalides on the structural and magnetic properties of Co(ii) hexacoordinate single-molecule magnets.	pseudohalides	32-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-97
29214722-3	2018	The best water oxidation activity is obtained with cobalt hydroxide carbonate templated t-CoII -CoIII with an overpotential as low as 240 mV to reach a current density of 10 mA cm-2 .	Water	9-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-94
29406528-0	2018	Corrigendum: Taheebo Polyphenols Attenuate FFA-Induced Inflammation in Murine and Human Macrophage Cell Lines As Inhibitor of COX-2.	taheebo polyphenols	13-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-131
29406528-0	2018	Corrigendum: Taheebo Polyphenols Attenuate FFA-Induced Inflammation in Murine and Human Macrophage Cell Lines As Inhibitor of COX-2.	Flufenamic Acid	43-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-131
29105862-4	2018	In contrast, {[Co2 (pbcd)(bpe)] 2 H2 O 2 DMF}n (3; bpe=1,2-bis(pyridin-4-yl)ethane) containing binuclear CoII and having large pore windows is a highly selective catalyst for obtaining exclusively the acylation products.	{[co2	13-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-109
29105862-4	2018	In contrast, {[Co2 (pbcd)(bpe)] 2 H2 O 2 DMF}n (3; bpe=1,2-bis(pyridin-4-yl)ethane) containing binuclear CoII and having large pore windows is a highly selective catalyst for obtaining exclusively the acylation products.	pbcd)(bpe)] 2 h2 o 2 dmf	20-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-109
29105862-4	2018	In contrast, {[Co2 (pbcd)(bpe)] 2 H2 O 2 DMF}n (3; bpe=1,2-bis(pyridin-4-yl)ethane) containing binuclear CoII and having large pore windows is a highly selective catalyst for obtaining exclusively the acylation products.	1,2-bis(pyridin-4-yl)ethane	55-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-109
29120070-1	2018	A CoII /Box-catalyzed [Box=bis(oxazoline)] enantioselective addition of potassium allyltrifluoroborate to cyclic ketimines was developed, providing the corresponding chiral alpha-tertiary amines in high yields and with good enantioselectivity values.	bis(oxazoline)	27-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	2-6
29120070-1	2018	A CoII /Box-catalyzed [Box=bis(oxazoline)] enantioselective addition of potassium allyltrifluoroborate to cyclic ketimines was developed, providing the corresponding chiral alpha-tertiary amines in high yields and with good enantioselectivity values.	Potassium allyltrifluoroborate	72-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	2-6
29381136-2	2018	The conserved mitochondrial-encoded COX1- and COX2-subunits are the heme- and copper-center containing core subunits that catalyze water formation.	Heme	68-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-50
29381136-2	2018	The conserved mitochondrial-encoded COX1- and COX2-subunits are the heme- and copper-center containing core subunits that catalyze water formation.	Copper	78-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-50
29381136-2	2018	The conserved mitochondrial-encoded COX1- and COX2-subunits are the heme- and copper-center containing core subunits that catalyze water formation.	Water	131-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-50
29240988-8	2018	The homolytic aromatic substitution reactions do not require a sacrificial or substrate-derived oxidant because the CoII by-product of CoIII -CF3 homolysis produces H2 .	Hydrogen	165-167	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-120
29214722-3	2018	The best water oxidation activity is obtained with cobalt hydroxide carbonate templated t-CoII -CoIII with an overpotential as low as 240 mV to reach a current density of 10 mA cm-2 .	cobalt hydroxide carbonate	51-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-94
29120070-1	2018	A CoII /Box-catalyzed [Box=bis(oxazoline)] enantioselective addition of potassium allyltrifluoroborate to cyclic ketimines was developed, providing the corresponding chiral alpha-tertiary amines in high yields and with good enantioselectivity values.	cyclic ketimines	106-122	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	2-6
29120070-1	2018	A CoII /Box-catalyzed [Box=bis(oxazoline)] enantioselective addition of potassium allyltrifluoroborate to cyclic ketimines was developed, providing the corresponding chiral alpha-tertiary amines in high yields and with good enantioselectivity values.	Amines	188-194	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	2-6
29313041-1	2018	Orientation selective (OS) RIDME and PELDOR were conducted on a low-spin CoII complex coordinated by two nitroxide (NO) labelled 2,2":6",2""-terpyridine ligands.	Hydroxylamine	105-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-77
29368698-0	2018	Ingenol-3-Angelate Suppresses Growth of Melanoma Cells and Skin Tumor Development by Downregulation of NF-kappaB-Cox2 Signaling.	3-ingenyl angelate	0-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-117
29168867-8	2018	In this study, we found that phloretin significantly inhibited the IL-1beta-induced production of NO, PGE2, TNF-alpha, and IL-6, the expression of COX-2, iNOS, MMP-3, MMP-13, and ADAMTS-5, and the degradation of aggrecan and collagen-II in human OA chondrocytes.	Phloretin	29-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-152
29313041-1	2018	Orientation selective (OS) RIDME and PELDOR were conducted on a low-spin CoII complex coordinated by two nitroxide (NO) labelled 2,2":6",2""-terpyridine ligands.	(2,2'-6',2'')-terpyridine	129-152	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-77
29174987-2	2018	MLX has a preferential affinity for COX-2, which is associated with a lower incidence of gastrointestinal side effects.	Meloxicam	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-41
29299581-0	2018	Reaction of tin(iv) phthalocyanine dichloride with decamethylmetallocenes (M = CrII and CoII).	Tin	12-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-92
29299581-0	2018	Reaction of tin(iv) phthalocyanine dichloride with decamethylmetallocenes (M = CrII and CoII).	iv) phthalocyanine dichloride	16-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-92
29299581-0	2018	Reaction of tin(iv) phthalocyanine dichloride with decamethylmetallocenes (M = CrII and CoII).	decamethylmetallocenes	51-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-92
29260180-1	2018	Several complexes of Co(ii) or Fe(ii) with 1,4,7,10-tetraazacyclododecane (CYCLEN) appended with 1,7-(6-methyl)2-picolyl groups are studied as 1H NMR paraSHIFT agents (paramagnetic shift agents) for the registration of temperature.	cyclen	43-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-27
29260180-1	2018	Several complexes of Co(ii) or Fe(ii) with 1,4,7,10-tetraazacyclododecane (CYCLEN) appended with 1,7-(6-methyl)2-picolyl groups are studied as 1H NMR paraSHIFT agents (paramagnetic shift agents) for the registration of temperature.	cyclen	43-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-26
29260180-1	2018	Several complexes of Co(ii) or Fe(ii) with 1,4,7,10-tetraazacyclododecane (CYCLEN) appended with 1,7-(6-methyl)2-picolyl groups are studied as 1H NMR paraSHIFT agents (paramagnetic shift agents) for the registration of temperature.	Hydrogen	143-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-27
29260180-1	2018	Several complexes of Co(ii) or Fe(ii) with 1,4,7,10-tetraazacyclododecane (CYCLEN) appended with 1,7-(6-methyl)2-picolyl groups are studied as 1H NMR paraSHIFT agents (paramagnetic shift agents) for the registration of temperature.	Hydrogen	143-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-26
29260180-5	2018	The 1H NMR spectra of both of the Fe(ii) complexes and one of the Co(ii) complexes are consistent with a predominant diastereomeric form in deuterium oxide solutions.	Hydrogen	4-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-39
29260180-5	2018	The 1H NMR spectra of both of the Fe(ii) complexes and one of the Co(ii) complexes are consistent with a predominant diastereomeric form in deuterium oxide solutions.	Hydrogen	4-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-72
29260180-5	2018	The 1H NMR spectra of both of the Fe(ii) complexes and one of the Co(ii) complexes are consistent with a predominant diastereomeric form in deuterium oxide solutions.	Deuterium	140-149	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-39
29260180-5	2018	The 1H NMR spectra of both of the Fe(ii) complexes and one of the Co(ii) complexes are consistent with a predominant diastereomeric form in deuterium oxide solutions.	Deuterium	140-149	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-72
29211477-0	2018	Titanium(III)-Oxo Clusters in a Metal-Organic Framework Support Single-Site Co(II)-Hydride Catalysts for Arene Hydrogenation.	titanium(iii)-oxo	0-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-81
29260180-10	2018	The crystal structure of [Co(BMPC)]Cl2 shows a six-coordinate Co(ii) bound to the macrocyclic amines and two pendent picolyl groups.	co(bmpc)]cl2	26-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-68
29260180-10	2018	The crystal structure of [Co(BMPC)]Cl2 shows a six-coordinate Co(ii) bound to the macrocyclic amines and two pendent picolyl groups.	Amines	94-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-68
29225187-6	2018	The principal aim of this study was to establish whether COX-1 and/or COX-2 mediates PGD2 generation from human lung mast cells.	Prostaglandin D2	85-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-75
28846901-1	2018	A novel nitrogen-doped biochar embedded with cobalt (Co-NB) was fabricated via pyrolysis of glucose pretreated with melamine (N donor) and Co(II).	Nitrogen	8-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-145
28846901-1	2018	A novel nitrogen-doped biochar embedded with cobalt (Co-NB) was fabricated via pyrolysis of glucose pretreated with melamine (N donor) and Co(II).	Cobalt	45-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-145
28846901-1	2018	A novel nitrogen-doped biochar embedded with cobalt (Co-NB) was fabricated via pyrolysis of glucose pretreated with melamine (N donor) and Co(II).	co-nb	53-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-145
29594450-4	2018	If, however, the CoOOH sheets are reduced to Co(II) ions in the presence of ascorbic acid (AA), fluorescence recovers.	Ascorbic Acid	76-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-51
29211477-0	2018	Titanium(III)-Oxo Clusters in a Metal-Organic Framework Support Single-Site Co(II)-Hydride Catalysts for Arene Hydrogenation.	Metals	32-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-81
29211477-0	2018	Titanium(III)-Oxo Clusters in a Metal-Organic Framework Support Single-Site Co(II)-Hydride Catalysts for Arene Hydrogenation.	arene	105-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-81
29211477-4	2018	Herein we report that the Ti8(mu2-O)8(mu2-OH)4 node of the Ti-BDC MOF (MIL-125) provides a single-site model of the classical TiO2 support to enable CoII-hydride-catalyzed arene hydrogenation.	mil-125	71-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	149-153
29211477-4	2018	Herein we report that the Ti8(mu2-O)8(mu2-OH)4 node of the Ti-BDC MOF (MIL-125) provides a single-site model of the classical TiO2 support to enable CoII-hydride-catalyzed arene hydrogenation.	titanium dioxide	126-130	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	149-153
29211477-4	2018	Herein we report that the Ti8(mu2-O)8(mu2-OH)4 node of the Ti-BDC MOF (MIL-125) provides a single-site model of the classical TiO2 support to enable CoII-hydride-catalyzed arene hydrogenation.	arene	172-177	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	149-153
29316620-2	2018	Aspirin is the most commonly used non-steroid anti-inflammatory drugs (NSAIDs), and it irreversibly inhibits cyclooxygenase-1 and -2 (COX1, COX2).	Aspirin	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-144
29316620-4	2018	The lower aspirin doses causing only minimal gastrointestinal disturbance, ideal for long-term use, can achieve only partial and transitory inhibition of COX2.	Aspirin	10-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	154-158
29316620-5	2018	Aspirin"s principal metabolite, salicylic acid, is also found in fruits and vegetables that inhibit COX2.	Aspirin	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-104
29316620-5	2018	Aspirin"s principal metabolite, salicylic acid, is also found in fruits and vegetables that inhibit COX2.	Salicylic Acid	32-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-104
29316620-6	2018	Other phytochemicals such as curcumin, resveratrol, and anthocyanins also inhibit COX2.	Curcumin	29-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-86
29316620-6	2018	Other phytochemicals such as curcumin, resveratrol, and anthocyanins also inhibit COX2.	Resveratrol	39-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-86
29316620-6	2018	Other phytochemicals such as curcumin, resveratrol, and anthocyanins also inhibit COX2.	Anthocyanins	56-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-86
28648567-8	2018	There was a tendency for both EPA and DHA groups to decrease COX-2 gene expressions.	Eicosapentaenoic Acid	30-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-66
28648567-8	2018	There was a tendency for both EPA and DHA groups to decrease COX-2 gene expressions.	Docosahexaenoic Acids	38-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-66
29231218-1	2018	We successfully developed an approach to synthesize a metal oxide- and N-codoped carbon nanosheet, NC@CoO/CuO, derived from a metal-organic framework nanofiber, Cu(ii)-Asp@Co(II) (Asp = l-aspartate).	metal oxide	54-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	172-178
29231218-1	2018	We successfully developed an approach to synthesize a metal oxide- and N-codoped carbon nanosheet, NC@CoO/CuO, derived from a metal-organic framework nanofiber, Cu(ii)-Asp@Co(II) (Asp = l-aspartate).	Nitrogen	71-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	172-178
29231218-1	2018	We successfully developed an approach to synthesize a metal oxide- and N-codoped carbon nanosheet, NC@CoO/CuO, derived from a metal-organic framework nanofiber, Cu(ii)-Asp@Co(II) (Asp = l-aspartate).	Carbon	81-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	172-178
29231218-1	2018	We successfully developed an approach to synthesize a metal oxide- and N-codoped carbon nanosheet, NC@CoO/CuO, derived from a metal-organic framework nanofiber, Cu(ii)-Asp@Co(II) (Asp = l-aspartate).	carboxyl radical	102-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	172-178
29231218-1	2018	We successfully developed an approach to synthesize a metal oxide- and N-codoped carbon nanosheet, NC@CoO/CuO, derived from a metal-organic framework nanofiber, Cu(ii)-Asp@Co(II) (Asp = l-aspartate).	Metals	54-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	172-178
29231218-1	2018	We successfully developed an approach to synthesize a metal oxide- and N-codoped carbon nanosheet, NC@CoO/CuO, derived from a metal-organic framework nanofiber, Cu(ii)-Asp@Co(II) (Asp = l-aspartate).	cu(ii)	161-167	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	172-178
29231218-1	2018	We successfully developed an approach to synthesize a metal oxide- and N-codoped carbon nanosheet, NC@CoO/CuO, derived from a metal-organic framework nanofiber, Cu(ii)-Asp@Co(II) (Asp = l-aspartate).	Aspartic Acid	168-171	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	172-178
29231218-1	2018	We successfully developed an approach to synthesize a metal oxide- and N-codoped carbon nanosheet, NC@CoO/CuO, derived from a metal-organic framework nanofiber, Cu(ii)-Asp@Co(II) (Asp = l-aspartate).	Aspartic Acid	180-183	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	172-178
29231218-1	2018	We successfully developed an approach to synthesize a metal oxide- and N-codoped carbon nanosheet, NC@CoO/CuO, derived from a metal-organic framework nanofiber, Cu(ii)-Asp@Co(II) (Asp = l-aspartate).	Aspartic Acid	186-197	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	172-178
29235601-7	2018	Molecular docking studies with COX-2 reveal that complexes 1 and 2 having naproxen and diclofenac ligands exhibit stronger interactions with COX-2 than their respective free NSAIDs and these results are in good agreement with their relative experimentally observed COX inhibition as well as anti-proliferative activities.	Naproxen	74-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-36
29235601-7	2018	Molecular docking studies with COX-2 reveal that complexes 1 and 2 having naproxen and diclofenac ligands exhibit stronger interactions with COX-2 than their respective free NSAIDs and these results are in good agreement with their relative experimentally observed COX inhibition as well as anti-proliferative activities.	Naproxen	74-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	141-146
29235601-7	2018	Molecular docking studies with COX-2 reveal that complexes 1 and 2 having naproxen and diclofenac ligands exhibit stronger interactions with COX-2 than their respective free NSAIDs and these results are in good agreement with their relative experimentally observed COX inhibition as well as anti-proliferative activities.	Diclofenac	87-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-36
29235601-7	2018	Molecular docking studies with COX-2 reveal that complexes 1 and 2 having naproxen and diclofenac ligands exhibit stronger interactions with COX-2 than their respective free NSAIDs and these results are in good agreement with their relative experimentally observed COX inhibition as well as anti-proliferative activities.	Diclofenac	87-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	141-146
29257677-2	2018	In this work, {Co-NO}8 complexes are induced to convert from (CoII)+ -NO  to CoIII-NO- by a core contraction of 0.06 A in saddled cobalt(II) porphyrins.	co-no	15-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-66
29257677-2	2018	In this work, {Co-NO}8 complexes are induced to convert from (CoII)+ -NO  to CoIII-NO- by a core contraction of 0.06 A in saddled cobalt(II) porphyrins.	cobalt(ii) porphyrins	130-151	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-66
29303495-3	2018	It consists of a mononuclear unit with the CoII ion on an inversion centre coordinated by two 2,6-diamino-7H-purin-1-ium cations, two 4,4"-oxydibenzoate anions (in a nonbridging kappaO-monodentate coordination mode, which is less common for the anion in its CoII complexes) and two water molecules, defining an octahedral environment around the metal atom.	Water	282-287	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-47
29303495-3	2018	It consists of a mononuclear unit with the CoII ion on an inversion centre coordinated by two 2,6-diamino-7H-purin-1-ium cations, two 4,4"-oxydibenzoate anions (in a nonbridging kappaO-monodentate coordination mode, which is less common for the anion in its CoII complexes) and two water molecules, defining an octahedral environment around the metal atom.	Metals	345-350	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-47
30178377-9	2018	Cytokine stimulation was found to differentially affect gene expression of major ROS synthesizing enzymes: eNOS was decreased whereas COX-2 and NOX-4 were increased.	ros	81-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-139
29866021-8	2018	Activation of NF-kappaB, expression of COX2, HIF-1alpha and cMyc, as well as expression and activity of LDH-A were significantly reduced by curcumin.	Curcumin	140-148	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-43
29962266-7	2018	FCGR3- NK with a phenotype of PTGS2/COX2high IFNGlow PRF1low GZMBlow induced by hck knockout (hck-/-) or 3-methyladenine (3-MA, an autophagy inhibitor)-stimulated ESCs accelerates ESC"s growth both in vitro and in vivo.	3-methyladenine	105-120	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-40
28993190-7	2018	Meanwhile, the infusion of HPO CM activated the COX2-PGE2 axis both in vitro and in vivo.	Dinoprostone	53-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-52
28993190-11	2018	In conclusion, the secretome from hypoxia-conditioned ADMSCs facilitates the repair of gastric mucosal injury through the enhancement of angiogenesis and re-epithelization, as well as the activation of COX2-PGE2 axis with a paracrine activity involving CCL-20 factor.	Dinoprostone	207-211	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	202-206
29017895-5	2018	A reduction in peroxisome proliferator-activated receptor gamma coactivator-1 alpha and Cytochrome c oxidase subunit II by fructose treatment is indicative of mitochondrial dysfunction.	Fructose	123-131	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-119
29191502-0	2018	Synthesis, in vitro and in silico evaluation of novel trans-stilbene analogues as potential COX-2 inhibitors.	Stilbenes	54-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-97
29191502-6	2018	Its ability to inhibit COX-2 in MCF-7 cell line was established and its cytotoxicity by MTT test was assessed.	monooxyethylene trimethylolpropane tristearate	88-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-28
29191502-8	2018	Finally, the investigated trans-stilbene was docked into COX-1 and COX-2 active sites using "CDOCKER" protocol.	Stilbenes	26-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-72
29109117-9	2018	Gene expression analyses from tissue obtained at endpoint of the trial demonstrated inhibition of the cancer pathways COX2/PGE2, EGFR, and WNT.	Dinoprostone	123-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-122
29180467-3	2018	Here, we report that the proinflammatory COX2/PGE2 pathway and the YAP1 growth-regulatory pathway cooperate to recruit the stem cell factor SOX2 in expanding and sustaining the accumulation of urothelial CSCs.	Dinoprostone	46-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-45
29732985-9	2018	The optimal pharmacologic treatment for chronic articular pain in these patients is paracetamol and COX-2 inhibitors (celecoxib and rofecoxib).	Celecoxib	118-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-105
29732985-9	2018	The optimal pharmacologic treatment for chronic articular pain in these patients is paracetamol and COX-2 inhibitors (celecoxib and rofecoxib).	rofecoxib	132-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-105
29884091-2	2018	Here, we reported that celecoxib, a selective COX-2 inhibitor in the NSAID class, exhibits strong antitumor activity in dose dependent manner in two OS cell lines-143B and U2OS.	Celecoxib	23-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
29180467-4	2018	Mechanistically, COX2/PGE2 signaling induced promoter methylation of let-7, resulting in its downregulation and subsequent SOX2 upregulation.	Dinoprostone	22-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-21
29180467-7	2018	Additional investigations suggested that activation of the COX2/PGE2 and YAP1 pathways also promoted acquired resistance to EGFR inhibitors in basal-type UCB.	Dinoprostone	64-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-63
29180467-9	2018	Our findings provide a preclinical rationale to target these pathways concurrently with systemic chemotherapy as a strategy to improve the clinical management of UCB.Significance: These findings offer a preclinical rationale to target the COX2 and YAP1 pathways concurrently with systemic chemotherapy to improve the clinical management of UCB, based on evidence that these two pathways expand cancer stem-like cell populations that mediate resistance to chemotherapy.	ucb	162-165	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	239-243
30261513-9	2018	Oleocanthal inhibited NO production and strongly decreased NOS2 and COX-2 protein and mRNA expression in LPS-activated human primary OA chondrocytes.	oleocanthal	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-73
29723847-10	2018	In particular, in the result from an RNA interference-mediated assay, our finding showed that silencing of Tollip resulted in abrogation of the inhibitory action of EGCG on LPS-induced production of pro-inflammatory mediators (inducible nitric oxide synthase-mediated NO/COX2, and IL-8) and activation of MAPKs and NF-kappaB signaling pathways.	epigallocatechin gallate	165-169	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	271-275
29105860-3	2018	Recently, we reported a series of novel molecular architectures based on a modified tris(2-pyridylmethyl)amine complex (TPMA), which are able to amplify the electronic CD, in the case of Zn(II) assemblies and vibrational CD, in the case of Co(II) assemblies.	tris(2-pyridylmethyl)amine	84-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	240-246
29105860-3	2018	Recently, we reported a series of novel molecular architectures based on a modified tris(2-pyridylmethyl)amine complex (TPMA), which are able to amplify the electronic CD, in the case of Zn(II) assemblies and vibrational CD, in the case of Co(II) assemblies.	Cadmium	168-170	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	240-246
29105860-3	2018	Recently, we reported a series of novel molecular architectures based on a modified tris(2-pyridylmethyl)amine complex (TPMA), which are able to amplify the electronic CD, in the case of Zn(II) assemblies and vibrational CD, in the case of Co(II) assemblies.	Cadmium	221-223	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	240-246
30285927-6	2018	The prothrombotic effect could be due to the inhibition of endothelial COX-2, with a decrease in production of prostacyclin and a relative increase in platelet thromboxane levels.	Epoprostenol	111-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-76
29391779-10	2018	A molecular docking study of compound 5 showed that xanthone formed binding interactions with some receptors involved in cancer pathology, including telomerase, tumor-promoting inflammation (COX-2), and cyclin-dependent kinase-2 (CDK2) inhibitor.	xanthone	52-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	191-196
28179185-3	2018	The mechanism of action of DS operates by way of cyclooxygenase (COX) inhibition.	Diclofenac	27-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-68
28179185-6	2018	As a non-steroidal anti-inflammatory drug (NSAID), DS binds to both forms of COX (COX-1 and COX-2) and inhibits the conversion of arachidonic acid into pro-inflammatory prostaglandins by means of chelation.	Diclofenac	51-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-80
28179185-6	2018	As a non-steroidal anti-inflammatory drug (NSAID), DS binds to both forms of COX (COX-1 and COX-2) and inhibits the conversion of arachidonic acid into pro-inflammatory prostaglandins by means of chelation.	Diclofenac	51-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-97
28179185-8	2018	DS is effective in overcoming pain and inflammation when it inhibits COX-2, but gastrointestinal side effects appear when it inhibits COX-1.	Diclofenac	0-2	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-74
28870762-2	2018	Diclofenac sodium (DS), one of these NSAIDs, has a high specificity for arachidonic acid-degrading cyclooxygenase (COX)-2 enzymes.	Diclofenac	0-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-121
28870762-2	2018	Diclofenac sodium (DS), one of these NSAIDs, has a high specificity for arachidonic acid-degrading cyclooxygenase (COX)-2 enzymes.	Diclofenac	19-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-121
28870762-2	2018	Diclofenac sodium (DS), one of these NSAIDs, has a high specificity for arachidonic acid-degrading cyclooxygenase (COX)-2 enzymes.	arachidonic	72-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-121
29804536-0	2018	Design, Synthesis and Biological Evaluation of New 1,3-diphenyl-3- (phenylamino)propan-1-ones as Selective Cyclooxygenase (COX-2) Inhibitors.	1,3-diphenyl-3- (phenylamino)propan-1-ones	51-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-128
29804536-4	2018	OBJECTIVE: A new group of 1,3-diphenyl-3-(phenylamino)propan-1-ones was designed and synthesized to investigate for their COX-2 inhibitory activity and inhibition of platelet aggregation.	1,3-diphenyl-3-(phenylamino)propan-1-ones	26-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-127
29804536-9	2018	Molecular modeling and docking studies indicated that synthesized compounds had a binding similar to that of the known inhibitor SC-558 and the SO2Me group was inserted into the COX-2 secondary pocket (Val523, Phe518, Ile517, Arg513 and His90) and C=O of the central alpha, beta-unsaturated-carbonyl moiety was oriented toward the entrance to the COX-2 binding site (Tyr355 and Arg120).	so2me	144-149	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	178-183
29804536-9	2018	Molecular modeling and docking studies indicated that synthesized compounds had a binding similar to that of the known inhibitor SC-558 and the SO2Me group was inserted into the COX-2 secondary pocket (Val523, Phe518, Ile517, Arg513 and His90) and C=O of the central alpha, beta-unsaturated-carbonyl moiety was oriented toward the entrance to the COX-2 binding site (Tyr355 and Arg120).	so2me	144-149	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	347-352
29804536-10	2018	CONCLUSION: The 1,3-diphenyl-3-(phenylamino)propan-1-ones are novel COX-2 inhibitors with good COX-2 inhibitory and low affinity for COX-1 isoenzyme.	1,3-diphenyl-3-(phenylamino)propan-1-ones	16-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-73
29804536-10	2018	CONCLUSION: The 1,3-diphenyl-3-(phenylamino)propan-1-ones are novel COX-2 inhibitors with good COX-2 inhibitory and low affinity for COX-1 isoenzyme.	1,3-diphenyl-3-(phenylamino)propan-1-ones	16-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-100
28923362-7	2018	PGE2 and PGI2 were the predominant prostanoids produced in response to IH, reflecting COX-2 immunoreactivity.	Dinoprostone	0-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-91
28923362-7	2018	PGE2 and PGI2 were the predominant prostanoids produced in response to IH, reflecting COX-2 immunoreactivity.	Epoprostenol	9-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-91
28923362-7	2018	PGE2 and PGI2 were the predominant prostanoids produced in response to IH, reflecting COX-2 immunoreactivity.	Prostaglandins	35-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-91
29879894-0	2018	Evaluation of the Effect of alpha-L-Guluronic Acid (G2013) on COX-1, COX-2 Activity and Gene Expression for Introducing this Drug as a Novel NSAID with Immunomodulatory Property.	guluronic acid	28-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-74
29879894-0	2018	Evaluation of the Effect of alpha-L-Guluronic Acid (G2013) on COX-1, COX-2 Activity and Gene Expression for Introducing this Drug as a Novel NSAID with Immunomodulatory Property.	2,3,4,5-tetrahydroxy-6-oxohexanoic acid	52-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-74
33445373-5	2017	Subsequently, the obtained TA/PSBMA film was further chelated with CoII for specific binding to a His-tagged protein.	Tannins	27-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-71
29227102-0	2017	Electronic Structure of Cobalt-Corrole-Pyridine Complexes: Noninnocent Five-Coordinate Co(II) Corrole-Radical States.	cobalt-corrole-pyridine	24-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-92
29199735-0	2017	Ligand-free, palladacycle-facilitated Suzuki coupling of hindered 2-arylbenzothiazole derivatives yields potent and selective COX-2 inhibitors.	palladacycle	13-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-131
29199735-0	2017	Ligand-free, palladacycle-facilitated Suzuki coupling of hindered 2-arylbenzothiazole derivatives yields potent and selective COX-2 inhibitors.	2-arylbenzothiazole	66-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-131
29199735-1	2017	A similarity search and molecular modeling study suggested the 2"-aryl-2-arylbenzothiazole framework as a novel scaffold for the design of COX-2-selective inhibitors.	2"-aryl-2-arylbenzothiazole	63-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-144
29199735-6	2017	Six compounds had potencies in the submicromolar range against COX-2 and higher selectivity for COX-2 vs. COX-1 compared to the currently used drug celecoxib.	Celecoxib	148-157	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-68
29210572-4	2017	X-ray absorption spectroscopic studies showed that the Co K rising edge of Co[TPC](PPh3) (TPC = triphenylcorrole) is red-shifted by ~1.8 eV relative to the bona fide Co(III) complexes Co[TPC](py)2 and Co[TPP](py)Cl (TPP = tetraphenylporphyrin, py = pyridine), consistent with a partial CoII-corrole 2- description for Co[TPC](PPh3).	co[tpc]	75-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	286-290
29210572-4	2017	X-ray absorption spectroscopic studies showed that the Co K rising edge of Co[TPC](PPh3) (TPC = triphenylcorrole) is red-shifted by ~1.8 eV relative to the bona fide Co(III) complexes Co[TPC](py)2 and Co[TPP](py)Cl (TPP = tetraphenylporphyrin, py = pyridine), consistent with a partial CoII-corrole 2- description for Co[TPC](PPh3).	triphenylcorrole)	96-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	286-290
29210572-7	2017	Together, the results presented herein suggest that cobalt-corrole-triphenylphosphine complexes are significantly noninnocent with moderate CoII-corrole 2- character, underscoring-yet again-the ubiquity of ligand noninnocence among first-row transition metal corroles.	cobalt-corrole-triphenylphosphine	52-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-144
29237478-7	2017	Moreover, AM404 also inhibited the production of PGD2 and the formation of reactive oxygen species (8-iso-PGF2 alpha) with a reversible reduction of COX-1- and COX-2 activity.	N-(4-hydroxyphenyl)arachidonylamide	10-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	160-165
33445373-5	2017	Subsequently, the obtained TA/PSBMA film was further chelated with CoII for specific binding to a His-tagged protein.	sulfobetaine methacrylate polymer	30-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-71
29111674-1	2017	In the present work, gold electrodes were modified using a redox-active layer based on dipyrromethene complexes with Cu(II) or Co(II) and a dipodal anion receptor functionalized with dipyrromethene.	dipyrromethene	87-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	127-133
29111674-7	2017	The electrodes based on Co(II) redox centers displayed better selectivity toward Cl- anion detection than those based on Cu(II) centers which can be attributed to the stronger electronic interaction between the receptor-target anion complex and the Co(II)/Co(III) redox centers in comparison to the Cu(II)/Cu(I) system.	cl- anion	81-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-30
29111674-7	2017	The electrodes based on Co(II) redox centers displayed better selectivity toward Cl- anion detection than those based on Cu(II) centers which can be attributed to the stronger electronic interaction between the receptor-target anion complex and the Co(II)/Co(III) redox centers in comparison to the Cu(II)/Cu(I) system.	cl- anion	81-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	249-255
29111674-7	2017	The electrodes based on Co(II) redox centers displayed better selectivity toward Cl- anion detection than those based on Cu(II) centers which can be attributed to the stronger electronic interaction between the receptor-target anion complex and the Co(II)/Co(III) redox centers in comparison to the Cu(II)/Cu(I) system.	cu(ii)	121-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	249-255
29111674-7	2017	The electrodes based on Co(II) redox centers displayed better selectivity toward Cl- anion detection than those based on Cu(II) centers which can be attributed to the stronger electronic interaction between the receptor-target anion complex and the Co(II)/Co(III) redox centers in comparison to the Cu(II)/Cu(I) system.	cu(ii)	299-305	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-30
29111674-7	2017	The electrodes based on Co(II) redox centers displayed better selectivity toward Cl- anion detection than those based on Cu(II) centers which can be attributed to the stronger electronic interaction between the receptor-target anion complex and the Co(II)/Co(III) redox centers in comparison to the Cu(II)/Cu(I) system.	cu(ii)	299-305	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	249-255
29111674-7	2017	The electrodes based on Co(II) redox centers displayed better selectivity toward Cl- anion detection than those based on Cu(II) centers which can be attributed to the stronger electronic interaction between the receptor-target anion complex and the Co(II)/Co(III) redox centers in comparison to the Cu(II)/Cu(I) system.	cuprous ion	306-311	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-30
29111674-7	2017	The electrodes based on Co(II) redox centers displayed better selectivity toward Cl- anion detection than those based on Cu(II) centers which can be attributed to the stronger electronic interaction between the receptor-target anion complex and the Co(II)/Co(III) redox centers in comparison to the Cu(II)/Cu(I) system.	cuprous ion	306-311	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	249-255
29111674-8	2017	Applicability of gold electrodes modified with DPM-Co(II)-DPM-AR for the electrochemical determination of Cl- anions was demonstrated using the artificial matrix mimicking human serum.	Argon	62-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-57
28683368-3	2017	The cation (+1) complexes contain a diethylenetriamine (dien) as auxiliary ligand and their structures were calculated by DFT studies which were also performed for the CoII (S=1/2 and S=3/2) configurations.	diethylenetriamine	56-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	168-172
28683368-5	2017	Cyclic voltammetry studies showed that structural modifications made in the L2- ligands caused a slight influence on the electronic density of the metal center, and the E1/2 values for the CoIII/CoII redox couple increased following the electronic effect of the R-substituent, in the order: 2 (R=OCH3)&lt;1 (R=H)&lt;3 (R=Cl).	Metals	147-152	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	189-193
29318300-2	2017	The virtual combinatorial library of previously unknown spiro-condensed derivatives of [1,2,4]triazino[2,3-c]quinazolines was formed and promising COX-2 inhibitors were identified by molecular docking method.	[1,2,4]triazino[2,3-c]quinazolines	87-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-152
28990249-8	2017	Berberine can block the caspase 3-iPLA2 -AA-COX-2-PGE2 pathway by inhibiting the expression of iPLA2 and COX-2.	Berberine	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-49
29116428-7	2017	The combination of BEI-9 with CPT or TNFalpha inhibited NF-kappaB activation and reduced the expression of NF-kappaB-responsive genes, Bcl-xL and COX2.	bei-9	19-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	146-150
29116428-11	2017	BEI-9 reduced the expression of COX2 both alone and in combination with CPT or TNF.	bei-9	0-5	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-36
28990249-8	2017	Berberine can block the caspase 3-iPLA2 -AA-COX-2-PGE2 pathway by inhibiting the expression of iPLA2 and COX-2.	Berberine	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-110
28990249-8	2017	Berberine can block the caspase 3-iPLA2 -AA-COX-2-PGE2 pathway by inhibiting the expression of iPLA2 and COX-2.	Dinoprostone	50-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-49
28990249-8	2017	Berberine can block the caspase 3-iPLA2 -AA-COX-2-PGE2 pathway by inhibiting the expression of iPLA2 and COX-2.	Dinoprostone	50-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-110
29031075-1	2017	New ring-extended analogs of indomethacin were designed based on the structure of active binding site of both COX-1 and COX-2 isoenzymes and the interaction pattern required for selective inhibition of COX-2 to improve its selectivity against COX-2.	Indomethacin	29-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-125
29031075-1	2017	New ring-extended analogs of indomethacin were designed based on the structure of active binding site of both COX-1 and COX-2 isoenzymes and the interaction pattern required for selective inhibition of COX-2 to improve its selectivity against COX-2.	Indomethacin	29-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	202-207
29031075-1	2017	New ring-extended analogs of indomethacin were designed based on the structure of active binding site of both COX-1 and COX-2 isoenzymes and the interaction pattern required for selective inhibition of COX-2 to improve its selectivity against COX-2.	Indomethacin	29-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	202-207
29031075-4	2017	In vitro and in vivo assays for data profiling the new candidates revealed the significant improvement in the potency and selectivity against COX-2 of 6-methoxytetrahydrocarbazole 4 (IC50 = 0.97 mumol) to verify the effect of ring extension in comparison to indomethacin (IC50 = 2.63 mumol), and 6-methylsulfonyltetrahydrocarbazole 10a (IC50 = 0.28 mumol) to verify the effect of ring extension and introduction of methylsulfonyl group.	6-methoxytetrahydrocarbazole	151-179	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	142-147
29031075-4	2017	In vitro and in vivo assays for data profiling the new candidates revealed the significant improvement in the potency and selectivity against COX-2 of 6-methoxytetrahydrocarbazole 4 (IC50 = 0.97 mumol) to verify the effect of ring extension in comparison to indomethacin (IC50 = 2.63 mumol), and 6-methylsulfonyltetrahydrocarbazole 10a (IC50 = 0.28 mumol) to verify the effect of ring extension and introduction of methylsulfonyl group.	Indomethacin	258-270	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	142-147
29031075-4	2017	In vitro and in vivo assays for data profiling the new candidates revealed the significant improvement in the potency and selectivity against COX-2 of 6-methoxytetrahydrocarbazole 4 (IC50 = 0.97 mumol) to verify the effect of ring extension in comparison to indomethacin (IC50 = 2.63 mumol), and 6-methylsulfonyltetrahydrocarbazole 10a (IC50 = 0.28 mumol) to verify the effect of ring extension and introduction of methylsulfonyl group.	6-methylsulfonyltetrahydrocarbazole	296-331	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	142-147
29031075-4	2017	In vitro and in vivo assays for data profiling the new candidates revealed the significant improvement in the potency and selectivity against COX-2 of 6-methoxytetrahydrocarbazole 4 (IC50 = 0.97 mumol) to verify the effect of ring extension in comparison to indomethacin (IC50 = 2.63 mumol), and 6-methylsulfonyltetrahydrocarbazole 10a (IC50 = 0.28 mumol) to verify the effect of ring extension and introduction of methylsulfonyl group.	methylsulfonyl	298-312	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	142-147
29031075-5	2017	9-(4-chlorobenzoyl)-6-(methylsulfonyl)-1,2,3,9-tetrahydro-4H-carbazol-4-one 12a showed the most potential and selective activity against COX-2 (IC50 = 0.23 mumol) to be with superior potency to Celecoxib (IC50 = 0.30 mumol).	CHEMBL4169347	0-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-142
29031075-5	2017	9-(4-chlorobenzoyl)-6-(methylsulfonyl)-1,2,3,9-tetrahydro-4H-carbazol-4-one 12a showed the most potential and selective activity against COX-2 (IC50 = 0.23 mumol) to be with superior potency to Celecoxib (IC50 = 0.30 mumol).	Celecoxib	194-203	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-142
28853308-4	2017	In this study, pre-treatment of insulin inhibited MPP+-induced cell membrane damages on LDH and NO releases, which also inhibited the iNOS and Cox-2 levels.	mangion-purified polysaccharide (Candida albicans)	50-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	143-148
28756519-4	2017	IL-1beta-induced iNOS and COX-2 expression were also inhibited by Lico A.	licochalcone A	66-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-31
28378280-0	2017	Efficacy of phenyl quinoline phenol derivatives as COX-2 inhibitors; an approach to emergent the small molecules as the anti-inflammatory and analgesic therapeutics.	phenyl quinoline	12-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-56
28378280-0	2017	Efficacy of phenyl quinoline phenol derivatives as COX-2 inhibitors; an approach to emergent the small molecules as the anti-inflammatory and analgesic therapeutics.	Phenol	29-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-56
28378280-1	2017	2-(4-phenylquinoline-2-yl)phenol derivatives (4a-l) with COX-2 enzyme inhibition, analgesic, anti-inflammatory and antipyretic potentials were executed and reported.	2-(4-phenylquinoline-2-yl)phenol	0-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-62
28834104-10	2017	Myricetin suppresses the upregulation of COX2 induced by UV in keratinocyte as demonstrated by real-time PCR and Western blot.	myricetin	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-45
28834104-11	2017	Furthermore, signal transduction studies confirmed that myricetin attenuates the upregulation of COX2 induced by UV via suppression of IkappaB/NFkappaB pathways.	myricetin	56-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-101
28834104-12	2017	CONCLUSION: These results showed that antioxidant property of myricetin can effectively attenuate UV-caused cell damage and suppress the expression of COX2 through the IkappaB/NFkappaB signaling pathways.	myricetin	62-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-155
29031211-0	2017	Cyanidin-3-O-glucoside inhibits the UVB-induced ROS/COX-2 pathway in HaCaT cells.	cyanidin-3-o-glucoside	0-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-57
29031211-0	2017	Cyanidin-3-O-glucoside inhibits the UVB-induced ROS/COX-2 pathway in HaCaT cells.	ros	48-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-57
28772160-4	2017	The obtained results revealed that the benzothiazolopyrazolone derivative 13c was the most potent COX-2 inhibitor (IC50=0.10muM), while the 5-acetylbenzimidazolylpyrazolone derivative 12a was the most COX-2 selective (S.I.=104.67) in comparison with celecoxib (COX-2 IC50=1.11muM, S.I.=13.33).	benzothiazolopyrazolone	39-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-103
29173788-2	2017	These drugs inhibit cyclooxygenase 1 (COX-1), COX-2, and peroxidases, thus, blocking prostaglandin (PG) synthesis.	Prostaglandins	85-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
29173788-2	2017	These drugs inhibit cyclooxygenase 1 (COX-1), COX-2, and peroxidases, thus, blocking prostaglandin (PG) synthesis.	Prostaglandins	100-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
28976729-0	2017	Tip-Enhanced Raman Spectromicroscopy of Co(II)-Tetraphenylporphyrin on Au(111): Toward the Chemists" Microscope.	Gold	71-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-67
29238213-3	2017	AM404, formed through conjugation of paracetamol-derived p-aminophenol with arachidonic acid in the brain, is an activator of the capsaicin receptor, TRPV1, and inhibits the reuptake of the endocannabinoid, anandamide, into postsynaptic neurons, as well as inhibiting synthesis of PGE2 by COX-2.	N-(4-hydroxyphenyl)arachidonylamide	0-5	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	289-294
29238213-3	2017	AM404, formed through conjugation of paracetamol-derived p-aminophenol with arachidonic acid in the brain, is an activator of the capsaicin receptor, TRPV1, and inhibits the reuptake of the endocannabinoid, anandamide, into postsynaptic neurons, as well as inhibiting synthesis of PGE2 by COX-2.	Acetaminophen	37-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	289-294
29052339-3	2017	For a cobalt complex of the tetradentate methanol-bridged bispyridyl-bipyridyl complex [CoII Br(tpy)]Br, a detailed mechanistic picture is obtained by combining electrochemistry, spectroscopy, and photocatalysis.	Cobalt	6-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-92
29052339-3	2017	For a cobalt complex of the tetradentate methanol-bridged bispyridyl-bipyridyl complex [CoII Br(tpy)]Br, a detailed mechanistic picture is obtained by combining electrochemistry, spectroscopy, and photocatalysis.	Methanol	41-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-92
28929561-5	2017	Analogues of the sulfonamide-containing COX-2 inhibitor Celecoxib were prepared and evaluated.	Sulfonamides	17-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
28929561-5	2017	Analogues of the sulfonamide-containing COX-2 inhibitor Celecoxib were prepared and evaluated.	Celecoxib	56-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
28710928-2	2017	The Fe3O4 magnetic nanoparticles (Fe3O4 MNPs) modified by SiO2/aminopropyl trimethoxy silane/cyanuric chloride (Fe3O4@SiO2-APTMS/CC) utilized for anchoring metformin-cobalt complex (Fe3O4 Ms@SiO2-APTMS/CC/Met@Co(II)).	ferryl iron	4-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	209-215
28710928-2	2017	The Fe3O4 magnetic nanoparticles (Fe3O4 MNPs) modified by SiO2/aminopropyl trimethoxy silane/cyanuric chloride (Fe3O4@SiO2-APTMS/CC) utilized for anchoring metformin-cobalt complex (Fe3O4 Ms@SiO2-APTMS/CC/Met@Co(II)).	ferryl iron	34-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	209-215
28710928-2	2017	The Fe3O4 magnetic nanoparticles (Fe3O4 MNPs) modified by SiO2/aminopropyl trimethoxy silane/cyanuric chloride (Fe3O4@SiO2-APTMS/CC) utilized for anchoring metformin-cobalt complex (Fe3O4 Ms@SiO2-APTMS/CC/Met@Co(II)).	ferryl iron	34-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	209-215
29022345-3	2017	PXRD, solid-state spectroscopy, EM analysis, and quantum-chemical calculations suggest an outer sphere electron transfer from the COF to the co-catalyst which subsequently follows a monometallic pathway of H2 generation from the CoIII-hydride and/or CoII-hydride species.	COF protocol	130-133	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	229-233
29022345-3	2017	PXRD, solid-state spectroscopy, EM analysis, and quantum-chemical calculations suggest an outer sphere electron transfer from the COF to the co-catalyst which subsequently follows a monometallic pathway of H2 generation from the CoIII-hydride and/or CoII-hydride species.	Hydrogen	206-208	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	229-233
29399008-3	2017	Dimethylglyoxime (DMG) was used as a Co(II) and Ni(II) chelator with selective chemical precipitation for trace electrochemical analysis.	dimethylglyoxime	0-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-43
29399008-3	2017	Dimethylglyoxime (DMG) was used as a Co(II) and Ni(II) chelator with selective chemical precipitation for trace electrochemical analysis.	dimethylglyoxime	18-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-43
29180881-0	2017	Curcumin potentiates the potent antitumor activity of ACNU against glioblastoma by suppressing the PI3K/AKT and NF-kappaB/COX-2 signaling pathways.	Curcumin	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-127
29180881-0	2017	Curcumin potentiates the potent antitumor activity of ACNU against glioblastoma by suppressing the PI3K/AKT and NF-kappaB/COX-2 signaling pathways.	Nimustine	54-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-127
29180881-7	2017	Further, curcumin and ACNU acted synergistically in their antitumor effects by targeting N-cadherin/MMP2/9, PI3K/AKT, and NF-kappaB/COX-2 signaling.	Curcumin	9-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-137
29180881-7	2017	Further, curcumin and ACNU acted synergistically in their antitumor effects by targeting N-cadherin/MMP2/9, PI3K/AKT, and NF-kappaB/COX-2 signaling.	Nimustine	22-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-137
29058412-1	2017	Exposure to humid O2 or ambient air affords a 5-order-of-magnitude increase in electronic conductivity of a new Prussian blue analogue incorporating CoII and VIV-oxo units.	Oxygen	18-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	149-153
29058412-1	2017	Exposure to humid O2 or ambient air affords a 5-order-of-magnitude increase in electronic conductivity of a new Prussian blue analogue incorporating CoII and VIV-oxo units.	ferric ferrocyanide	112-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	149-153
29064238-4	2017	Two irreversible reductions are observed for (TpYPP)CoII and butano(TpYPP)CoII in CH2Cl2 containing 0.1 M tetra-n-butylammonium perchlorate; the first leads to the formation of a highly reactive cobalt(I) porphyrin, which can then rapidly react with a solvent to give a CoIIICH2Cl as the product.	Methylene Chloride	82-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-56
29064238-4	2017	Two irreversible reductions are observed for (TpYPP)CoII and butano(TpYPP)CoII in CH2Cl2 containing 0.1 M tetra-n-butylammonium perchlorate; the first leads to the formation of a highly reactive cobalt(I) porphyrin, which can then rapidly react with a solvent to give a CoIIICH2Cl as the product.	Methylene Chloride	82-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-78
29064238-4	2017	Two irreversible reductions are observed for (TpYPP)CoII and butano(TpYPP)CoII in CH2Cl2 containing 0.1 M tetra-n-butylammonium perchlorate; the first leads to the formation of a highly reactive cobalt(I) porphyrin, which can then rapidly react with a solvent to give a CoIIICH2Cl as the product.	tetrabutylammonium	106-139	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-56
29064238-4	2017	Two irreversible reductions are observed for (TpYPP)CoII and butano(TpYPP)CoII in CH2Cl2 containing 0.1 M tetra-n-butylammonium perchlorate; the first leads to the formation of a highly reactive cobalt(I) porphyrin, which can then rapidly react with a solvent to give a CoIIICH2Cl as the product.	tetrabutylammonium	106-139	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-78
29064238-4	2017	Two irreversible reductions are observed for (TpYPP)CoII and butano(TpYPP)CoII in CH2Cl2 containing 0.1 M tetra-n-butylammonium perchlorate; the first leads to the formation of a highly reactive cobalt(I) porphyrin, which can then rapidly react with a solvent to give a CoIIICH2Cl as the product.	cobalt(i) porphyrin	195-214	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-56
29064238-4	2017	Two irreversible reductions are observed for (TpYPP)CoII and butano(TpYPP)CoII in CH2Cl2 containing 0.1 M tetra-n-butylammonium perchlorate; the first leads to the formation of a highly reactive cobalt(I) porphyrin, which can then rapidly react with a solvent to give a CoIIICH2Cl as the product.	cobalt(i) porphyrin	195-214	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-78
29064238-4	2017	Two irreversible reductions are observed for (TpYPP)CoII and butano(TpYPP)CoII in CH2Cl2 containing 0.1 M tetra-n-butylammonium perchlorate; the first leads to the formation of a highly reactive cobalt(I) porphyrin, which can then rapidly react with a solvent to give a CoIIICH2Cl as the product.	coiiich2cl	270-280	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-56
29064238-4	2017	Two irreversible reductions are observed for (TpYPP)CoII and butano(TpYPP)CoII in CH2Cl2 containing 0.1 M tetra-n-butylammonium perchlorate; the first leads to the formation of a highly reactive cobalt(I) porphyrin, which can then rapidly react with a solvent to give a CoIIICH2Cl as the product.	coiiich2cl	270-280	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-78
29064238-7	2017	The first oxidation is metal-centered for the (TpYPP)Co and benzo(TpYPP)CoII derivatives, leading to generation of a cobalt(III) porphyrin with an intact pi-ring system, but this redox process is ring-centered in the case of butano(TpYPP)CoII and gives a CoII pi-cation radical product.	Metals	23-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-76
29064238-7	2017	The first oxidation is metal-centered for the (TpYPP)Co and benzo(TpYPP)CoII derivatives, leading to generation of a cobalt(III) porphyrin with an intact pi-ring system, but this redox process is ring-centered in the case of butano(TpYPP)CoII and gives a CoII pi-cation radical product.	Metals	23-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	238-242
29064238-7	2017	The first oxidation is metal-centered for the (TpYPP)Co and benzo(TpYPP)CoII derivatives, leading to generation of a cobalt(III) porphyrin with an intact pi-ring system, but this redox process is ring-centered in the case of butano(TpYPP)CoII and gives a CoII pi-cation radical product.	Metals	23-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	238-242
29064238-7	2017	The first oxidation is metal-centered for the (TpYPP)Co and benzo(TpYPP)CoII derivatives, leading to generation of a cobalt(III) porphyrin with an intact pi-ring system, but this redox process is ring-centered in the case of butano(TpYPP)CoII and gives a CoII pi-cation radical product.	tpypp	47-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-76
29064238-7	2017	The first oxidation is metal-centered for the (TpYPP)Co and benzo(TpYPP)CoII derivatives, leading to generation of a cobalt(III) porphyrin with an intact pi-ring system, but this redox process is ring-centered in the case of butano(TpYPP)CoII and gives a CoII pi-cation radical product.	tpypp	47-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	238-242
29064238-7	2017	The first oxidation is metal-centered for the (TpYPP)Co and benzo(TpYPP)CoII derivatives, leading to generation of a cobalt(III) porphyrin with an intact pi-ring system, but this redox process is ring-centered in the case of butano(TpYPP)CoII and gives a CoII pi-cation radical product.	tpypp	47-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	238-242
29064238-7	2017	The first oxidation is metal-centered for the (TpYPP)Co and benzo(TpYPP)CoII derivatives, leading to generation of a cobalt(III) porphyrin with an intact pi-ring system, but this redox process is ring-centered in the case of butano(TpYPP)CoII and gives a CoII pi-cation radical product.	cobalt(iii) porphyrin	117-138	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-76
29064238-7	2017	The first oxidation is metal-centered for the (TpYPP)Co and benzo(TpYPP)CoII derivatives, leading to generation of a cobalt(III) porphyrin with an intact pi-ring system, but this redox process is ring-centered in the case of butano(TpYPP)CoII and gives a CoII pi-cation radical product.	cobalt(iii) porphyrin	117-138	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	238-242
29064238-7	2017	The first oxidation is metal-centered for the (TpYPP)Co and benzo(TpYPP)CoII derivatives, leading to generation of a cobalt(III) porphyrin with an intact pi-ring system, but this redox process is ring-centered in the case of butano(TpYPP)CoII and gives a CoII pi-cation radical product.	cobalt(iii) porphyrin	117-138	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	238-242
29064238-7	2017	The first oxidation is metal-centered for the (TpYPP)Co and benzo(TpYPP)CoII derivatives, leading to generation of a cobalt(III) porphyrin with an intact pi-ring system, but this redox process is ring-centered in the case of butano(TpYPP)CoII and gives a CoII pi-cation radical product.	butano(tpypp)	225-238	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-76
29064238-9	2017	The number of electrons transferred (n) during ORRs is 2.0 for the butano(TpYPP)CoII derivatives, consistent with only H2O2 being produced as a product for the reaction with O2.	Hydrogen Peroxide	119-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-84
29064238-9	2017	The number of electrons transferred (n) during ORRs is 2.0 for the butano(TpYPP)CoII derivatives, consistent with only H2O2 being produced as a product for the reaction with O2.	Oxygen	121-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-84
29250391-5	2017	A barium-mu2-oxygen motif develops along the a axis, connecting symmetry-related dinuclear BaII-CoII cationic fragments in a wave-like chain, forming a one-dimensional metal coordination polymer.	Metals	168-173	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-100
29250391-8	2017	To our knowledge, this is the first example of a macrocyclic ligand forming a BaII-based one-dimensional coordination polymer, containing CoII ions surrounded by a N4O2 donor set.	Polymers	118-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	138-142
28810535-8	2017	In addition, curcumin enhanced radiosensitivity was through markedly inhibiting IR-induced NF-kappaB signaling by modulating the related protein expressions including NF-kappaBP65, I-kappaB, VEGF, COX2, and Bcl-2 in ACHN cells, which was further strengthened by NF-kappaB inhibitor PDTC treatment.	Curcumin	13-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	197-201
29030657-2	2017	There are limited studies assessing the risk of MI associated with meloxicam, an increasingly popular drug with COX-2 inhibiting properties.	Meloxicam	67-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-117
28842003-3	2017	For this purpose, cyclohexylamine at microL level was initially added into an aqueous solution containing Co(II), Ni(II), and Cu(II) ions which was placed in a glass test tube.	Cyclohexylamines	18-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-112
29149707-9	2017	The platelet count on Day 8, RP proportions on Days 1, 4, 8, and COX-2 level on Day 4 were significantly increased compared to their baseline levels in AR group but not in AS group.	Argon	152-154	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-70
29149707-10	2017	Platelet count on Day 8, RP proportion and COX-2 on Day 4 were all significantly higher in AR group than those in AS group.	Argon	91-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
29225427-0	2017	Molecular docking analysis of curcumin analogues with COX-2.	Curcumin	30-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-59
29225427-1	2017	Curcumin analogues were evaluated for COX-2 inhibitory as anti-inflammatory activities.	Curcumin	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-43
29225427-5	2017	Molecular docking study revealed the binding orientations of curcumin analogues in the active sites of COX-2 towards the design of potent inhibitors.	Curcumin	61-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-108
29186794-2	2017	LMT exhibited efficient adsorption of cobalt ions (Co(II)), and the adsorbed Co(II) was readily desorbed by nitric acid (HNO3).	Nitric Acid	108-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-83
29186794-2	2017	LMT exhibited efficient adsorption of cobalt ions (Co(II)), and the adsorbed Co(II) was readily desorbed by nitric acid (HNO3).	Nitric Acid	121-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-83
29186794-3	2017	All parameters affecting the adsorption and/or desorption of Co(II), including initial Co(II) concentration, pH value, temperature, HNO3 concentration, and time, were optimized.	Nitric Acid	132-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-67
29155869-7	2017	In addition, PPS regulated NF-kappaB (P65) signaling by interfering with Toll-like receptor (TLR)-4, INOS and cyclooxygenase (COX)-2.	pps	13-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-132
29250408-0	2017	Crystal structure of a zigzag CoII coordination polymer: catena-poly[[di-chlorido-bis-(methanol-kappaO)cobalt(II)]-mu-bis-(pyridin-3-ylmeth-yl)sulfane-kappa2N:N"].	Polymers	48-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-34
29250408-1	2017	Reaction of bis-(pyridin-3-ylmeth-yl)sulfane (L) with cobalt(II) chloride in methanol led to the formation of the title coordination polymer, [CoCl2(C12H12N2S)(CH3OH)2] n , in which the CoII cation lies on a crystallographic inversion centre and the S atom of the L ligand lies on a twofold rotation axis.	bis-(pyridin-3-ylmeth-yl)sulfane	12-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	186-190
29250408-1	2017	Reaction of bis-(pyridin-3-ylmeth-yl)sulfane (L) with cobalt(II) chloride in methanol led to the formation of the title coordination polymer, [CoCl2(C12H12N2S)(CH3OH)2] n , in which the CoII cation lies on a crystallographic inversion centre and the S atom of the L ligand lies on a twofold rotation axis.	cobaltous chloride	54-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	186-190
29250408-1	2017	Reaction of bis-(pyridin-3-ylmeth-yl)sulfane (L) with cobalt(II) chloride in methanol led to the formation of the title coordination polymer, [CoCl2(C12H12N2S)(CH3OH)2] n , in which the CoII cation lies on a crystallographic inversion centre and the S atom of the L ligand lies on a twofold rotation axis.	cobaltous chloride	143-148	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	186-190
29250408-2	2017	Each CoII ion is coordinated by two pyridine N atoms from two bridging L ligands, two O atoms from methanol mol-ecules and two chloride anions, all inversion-related.	pyridine	36-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	5-9
29250408-2	2017	Each CoII ion is coordinated by two pyridine N atoms from two bridging L ligands, two O atoms from methanol mol-ecules and two chloride anions, all inversion-related.	Nitrogen	45-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	5-9
29250408-2	2017	Each CoII ion is coordinated by two pyridine N atoms from two bridging L ligands, two O atoms from methanol mol-ecules and two chloride anions, all inversion-related.	Methanol	99-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	5-9
29250408-2	2017	Each CoII ion is coordinated by two pyridine N atoms from two bridging L ligands, two O atoms from methanol mol-ecules and two chloride anions, all inversion-related.	Chlorides	127-135	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	5-9
29250408-4	2017	Each L ligand links two CoII ions, forming an infinite zigzag chain propagating along the c-axis direction and further stabilized by O-H Cl hydrogen bonds between the methanol mol-ecules and the chloride anions.	Chlorides	195-203	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-28
28474563-7	2017	Recent studies uncover two mechanisms by which morphine may up-regulate P-gp and BCRP at the BBB: 1) via a glutamate, NMDA-receptor and COX-2 signaling cascade, and 2) via TLR4 activation, subsequent development of neuroinflammation, and activation of NF-kB, presumably via glial cells.	Morphine	47-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	136-141
29068449-0	2017	Heteroleptic complexes via solubility control: examples of Cu(ii), Co(ii), Ni(ii) and Mn(ii) complexes based on the derivatives of terpyridine and hydroxyquinoline.	2,2':6',2''-Terpyridine	131-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-64
29068449-0	2017	Heteroleptic complexes via solubility control: examples of Cu(ii), Co(ii), Ni(ii) and Mn(ii) complexes based on the derivatives of terpyridine and hydroxyquinoline.	2,2':6',2''-Terpyridine	131-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-73
29068449-0	2017	Heteroleptic complexes via solubility control: examples of Cu(ii), Co(ii), Ni(ii) and Mn(ii) complexes based on the derivatives of terpyridine and hydroxyquinoline.	2,2':6',2''-Terpyridine	131-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-72
29068449-0	2017	Heteroleptic complexes via solubility control: examples of Cu(ii), Co(ii), Ni(ii) and Mn(ii) complexes based on the derivatives of terpyridine and hydroxyquinoline.	2,2':6',2''-Terpyridine	131-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-72
29068449-0	2017	Heteroleptic complexes via solubility control: examples of Cu(ii), Co(ii), Ni(ii) and Mn(ii) complexes based on the derivatives of terpyridine and hydroxyquinoline.	Hydroxyquinolines	147-163	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-64
29068449-0	2017	Heteroleptic complexes via solubility control: examples of Cu(ii), Co(ii), Ni(ii) and Mn(ii) complexes based on the derivatives of terpyridine and hydroxyquinoline.	Hydroxyquinolines	147-163	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-73
29068449-0	2017	Heteroleptic complexes via solubility control: examples of Cu(ii), Co(ii), Ni(ii) and Mn(ii) complexes based on the derivatives of terpyridine and hydroxyquinoline.	Hydroxyquinolines	147-163	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-72
29068449-0	2017	Heteroleptic complexes via solubility control: examples of Cu(ii), Co(ii), Ni(ii) and Mn(ii) complexes based on the derivatives of terpyridine and hydroxyquinoline.	Hydroxyquinolines	147-163	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-72
28990778-8	2017	Compared with the BaP group, the autophagy inhibitor 3-MA significantly (p &lt; 0.01) inhibited the release of LDH by 70.53% +- 0.46 and NO by 50.36% +- 0.80, the increase of electrical conductivity by 12.08% +- 0.55, and the expressions of pyroptotic marker proteins (Caspase-1, Cox-2, IL-1beta, IL-18).	3-methyladenine	53-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	280-285
29290997-6	2017	We found COX-2 over-expression in PMP explant tissue, which is known to activate G-protein coupled EP4/cAMP/PKA/CREB signaling pathway.	Cyclic AMP	103-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	9-14
29290997-7	2017	MUC2 expression was reduced in vitro by small molecule inhibitors targeting EP4/PKA/CREB molecules and celecoxib (COX-2 inhibitor), and this was mediated by reduced CREB transcription factor binding to the MUC2 promoter.	Celecoxib	103-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-119
29250391-0	2017	Crystal structure of the BaII-based CoII-containing one-dimensional coordination polymer poly[[aqua{mu4-2,2"-[(4,10-dimethyl-1,4,7,10-tetra-aza-cyclo-dodecane-1,7-di-yl)bis(methylidene)]bis-(4-oxo-4H-pyran-3-olato)}-perchloratocobaltbarium] perchlorate].	Polymers	81-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-40
29250391-5	2017	A barium-mu2-oxygen motif develops along the a axis, connecting symmetry-related dinuclear BaII-CoII cationic fragments in a wave-like chain, forming a one-dimensional metal coordination polymer.	Barium	2-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-100
29250391-5	2017	A barium-mu2-oxygen motif develops along the a axis, connecting symmetry-related dinuclear BaII-CoII cationic fragments in a wave-like chain, forming a one-dimensional metal coordination polymer.	mu2-oxygen	9-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-100
29052412-0	2017	Co(II)-Doped Cd-MOF as an Efficient Water Oxidation Catalyst: Doubly Interpenetrated Boron Nitride Network with the Encapsulation of Free Ligand Containing Pyridine Moieties.	Water	36-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
29052412-0	2017	Co(II)-Doped Cd-MOF as an Efficient Water Oxidation Catalyst: Doubly Interpenetrated Boron Nitride Network with the Encapsulation of Free Ligand Containing Pyridine Moieties.	boron nitride	85-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
29052412-0	2017	Co(II)-Doped Cd-MOF as an Efficient Water Oxidation Catalyst: Doubly Interpenetrated Boron Nitride Network with the Encapsulation of Free Ligand Containing Pyridine Moieties.	pyridine	156-164	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
29052412-2	2017	Herein, a novel strategy has been demonstrated for developing the OER electrocatalyst by doping Co(II) in to a three-dimensional Cd-based MOF that contains a naked pyridine moieties in the form of uncoordinated ligand.	Cadmium	129-131	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-102
29052412-2	2017	Herein, a novel strategy has been demonstrated for developing the OER electrocatalyst by doping Co(II) in to a three-dimensional Cd-based MOF that contains a naked pyridine moieties in the form of uncoordinated ligand.	pyridine	164-172	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-102
29024866-1	2017	BACKGROUND AND AIMS: We aimed at investigating the effect of celecoxib (COX-2 selective inhibitor) and diclofenac (non-selective COX inhibitor) on endothelial function, and at identifying the underlying mechanisms in adjuvant-induced arthritis (AIA).	Celecoxib	61-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
28942223-12	2017	We found that baicalin significantly inhibited the IL-1beta-induced production of NO and PGE2, expression of COX-2, iNOS, MMP-3, MMP-13 and ADAMTS-5 and degradation of aggrecan and collagen-II.	baicalin	14-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-114
28964868-7	2017	Moreover, rosiglitazone significantly normalized the inflammatory responses (TNF-alpha and IL-1beta), NF-kappaB (p65), and inflammatory genes (iNOS and COX-2) in the hNSCs treated with AGEs.	Rosiglitazone	10-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-157
27667581-4	2017	The stability of the complexes of COX-1, COX-2, Topo I, Topo IIbeta and aromatase with the most potent inhibitor curcumin and those of the respective drugs, namely ibuprofen, aspirin, topotecan, etoposide, and exemestane were also analyzed through MD simulation analyses which revealed better stability of curcumin complexes than those of respective drugs.	Curcumin	113-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-46
28778815-2	2017	This study investigated whether 14 days of the selective Cox-2 inhibitor etoricoxib (60 mg/day) would modify self-report of pain intensity and quality, and physical measures of hyperalgesia and function in individuals with knee OA.	Etoricoxib	73-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-62
28733021-0	2017	Sonochemical synthesis and structural characterization of a new nanostructured Co(II) supramolecular coordination polymer with Lewis base sites as a new catalyst for Knoevenagel condensation.	Polymers	114-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-84
28733021-1	2017	A new Co(II) mixed-ligand coordination supramolecular polymer with composition [Co2(ppda)(4-bpdh)2(NO3)2]n (1) (where, ppda=p-phenylenediacrylic acid, 4-bpdh=2,5-bis(4-pyridyl)-3,4-diaza-2,4-hexadiene) was synthesized using solvothermal, mechanochemical and sonochemical methods.	co2(ppda)(4-bpdh	80-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	6-12
28733021-1	2017	A new Co(II) mixed-ligand coordination supramolecular polymer with composition [Co2(ppda)(4-bpdh)2(NO3)2]n (1) (where, ppda=p-phenylenediacrylic acid, 4-bpdh=2,5-bis(4-pyridyl)-3,4-diaza-2,4-hexadiene) was synthesized using solvothermal, mechanochemical and sonochemical methods.	4-(2'-pyridyldithio)benzyldiazoacetate	84-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	6-12
28733021-1	2017	A new Co(II) mixed-ligand coordination supramolecular polymer with composition [Co2(ppda)(4-bpdh)2(NO3)2]n (1) (where, ppda=p-phenylenediacrylic acid, 4-bpdh=2,5-bis(4-pyridyl)-3,4-diaza-2,4-hexadiene) was synthesized using solvothermal, mechanochemical and sonochemical methods.	1,4-Benzenediacrylic acid	124-149	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	6-12
28733021-1	2017	A new Co(II) mixed-ligand coordination supramolecular polymer with composition [Co2(ppda)(4-bpdh)2(NO3)2]n (1) (where, ppda=p-phenylenediacrylic acid, 4-bpdh=2,5-bis(4-pyridyl)-3,4-diaza-2,4-hexadiene) was synthesized using solvothermal, mechanochemical and sonochemical methods.	4-bpdh	90-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	6-12
28733021-1	2017	A new Co(II) mixed-ligand coordination supramolecular polymer with composition [Co2(ppda)(4-bpdh)2(NO3)2]n (1) (where, ppda=p-phenylenediacrylic acid, 4-bpdh=2,5-bis(4-pyridyl)-3,4-diaza-2,4-hexadiene) was synthesized using solvothermal, mechanochemical and sonochemical methods.	2,5-bis(4-pyridyl)-	158-177	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	6-12
28733021-1	2017	A new Co(II) mixed-ligand coordination supramolecular polymer with composition [Co2(ppda)(4-bpdh)2(NO3)2]n (1) (where, ppda=p-phenylenediacrylic acid, 4-bpdh=2,5-bis(4-pyridyl)-3,4-diaza-2,4-hexadiene) was synthesized using solvothermal, mechanochemical and sonochemical methods.	3,4-diaza-2,4-hexadiene	177-200	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	6-12
29152374-2	2017	The CoII cations are coordinated by two terminal N-bonding thio-cyanate anions and four N-bonding pyridine-4-carbo-thio-amide ligands, resulting in discrete and slightly distorted octa-hedral complexes.	Nitrogen	49-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-8
29152374-2	2017	The CoII cations are coordinated by two terminal N-bonding thio-cyanate anions and four N-bonding pyridine-4-carbo-thio-amide ligands, resulting in discrete and slightly distorted octa-hedral complexes.	thiocyanate	59-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-8
29152374-2	2017	The CoII cations are coordinated by two terminal N-bonding thio-cyanate anions and four N-bonding pyridine-4-carbo-thio-amide ligands, resulting in discrete and slightly distorted octa-hedral complexes.	Nitrogen	88-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-8
29152374-2	2017	The CoII cations are coordinated by two terminal N-bonding thio-cyanate anions and four N-bonding pyridine-4-carbo-thio-amide ligands, resulting in discrete and slightly distorted octa-hedral complexes.	pyridine-4-carbo-thio-amide	98-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-8
29152374-2	2017	The CoII cations are coordinated by two terminal N-bonding thio-cyanate anions and four N-bonding pyridine-4-carbo-thio-amide ligands, resulting in discrete and slightly distorted octa-hedral complexes.	octa-hedral	180-191	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-8
28869320-1	2017	Ultrafast, reversible intersystem crossing (ISC) is reported under ambient conditions for the electronic ground state of the pentacoordinate cobalt nitrosyl complexes, [CoX2 (NO)(PMePh2 )2 ] (X=Cl, Br), in solution.	cobalt nitrosyl	141-156	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	169-173
29059216-10	2017	DEX (1 mg/kg) also reduced the immunoexpression of cyclooxygenase (COX)-2, matrix metalloproteinase (MMP)-2, transforming growth factor (TGF)-beta, MIF, Smad 2/3, Smad 2/3 phosphorylated and NFkappaB p65 in the jugal mucosa.	Dexamethasone	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-73
28951911-0	2017	Cobalt(ii)-catalyzed bis-isocyanide insertion reactions with sulfonyl azides via nitrene radicals: chemoselective synthesis of sulfonylamidyl amide and 3-imine indole derivatives.	bis-isocyanide	21-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	7-9
28951911-0	2017	Cobalt(ii)-catalyzed bis-isocyanide insertion reactions with sulfonyl azides via nitrene radicals: chemoselective synthesis of sulfonylamidyl amide and 3-imine indole derivatives.	sulfonyl azides	61-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	7-9
28951911-0	2017	Cobalt(ii)-catalyzed bis-isocyanide insertion reactions with sulfonyl azides via nitrene radicals: chemoselective synthesis of sulfonylamidyl amide and 3-imine indole derivatives.	phenylnitrene	81-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	7-9
28951911-0	2017	Cobalt(ii)-catalyzed bis-isocyanide insertion reactions with sulfonyl azides via nitrene radicals: chemoselective synthesis of sulfonylamidyl amide and 3-imine indole derivatives.	sulfonylamidyl amide	127-147	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	7-9
28951911-0	2017	Cobalt(ii)-catalyzed bis-isocyanide insertion reactions with sulfonyl azides via nitrene radicals: chemoselective synthesis of sulfonylamidyl amide and 3-imine indole derivatives.	3-imine indole	152-166	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	7-9
28951911-1	2017	A chemoselective Co(ii)-catalyzed effective synthesis of sulfonylamidyl amide and 3-imine indole derivatives by using isocyanides and sulfonyl azides has been developed.	sulfonylamidyl amide	57-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22
28951911-1	2017	A chemoselective Co(ii)-catalyzed effective synthesis of sulfonylamidyl amide and 3-imine indole derivatives by using isocyanides and sulfonyl azides has been developed.	3-imine indole	82-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22
28951911-1	2017	A chemoselective Co(ii)-catalyzed effective synthesis of sulfonylamidyl amide and 3-imine indole derivatives by using isocyanides and sulfonyl azides has been developed.	Cyanides	118-129	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22
28951911-1	2017	A chemoselective Co(ii)-catalyzed effective synthesis of sulfonylamidyl amide and 3-imine indole derivatives by using isocyanides and sulfonyl azides has been developed.	sulfonyl azides	134-149	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22
28952621-8	2017	We found that OL significantly inhibited the IL-1beta-induced production of NO and PGE2; expression of COX-2, iNOS, MMP-1, MMP-13, and ADAMTS-5; and degradation of aggrecan and collagen-II.	oleuropein	14-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-108
29049420-8	2017	Furthermore, DAPT and LiCl decreased production of IL-1beta, TNF-alpha, IL-6, iNOS, Cox2 and MCP-1; however, IL-10 expression was increased notably in LiCl treated cells.	dapt	13-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-88
29049420-8	2017	Furthermore, DAPT and LiCl decreased production of IL-1beta, TNF-alpha, IL-6, iNOS, Cox2 and MCP-1; however, IL-10 expression was increased notably in LiCl treated cells.	Lithium Chloride	22-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-88
29049420-8	2017	Furthermore, DAPT and LiCl decreased production of IL-1beta, TNF-alpha, IL-6, iNOS, Cox2 and MCP-1; however, IL-10 expression was increased notably in LiCl treated cells.	Lithium Chloride	151-155	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-88
29254203-3	2017	PROS exerted significant cytotoxicity, induced sub-G1 phase and S phase arrest, increased apoptotic bodies, and attenuated the expression of pro-PARP, Bcl-2, Cyclin E, Cyclin A, CDK2, E2F1, p-Src, p-STAT3, p-ERK, p-AKT, COX-2 and SOCS-1 in A549 and H460 cells along with disrupted binding of STAT3 with CDK2 or VEGF.	Proline	0-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	220-225
29151957-0	2017	Curcumin Enhances the Anticancer Effect Of 5-fluorouracil against Gastric Cancer through Down-Regulation of COX-2 and NF- kappaB Signaling Pathways.	Curcumin	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-113
29151957-0	2017	Curcumin Enhances the Anticancer Effect Of 5-fluorouracil against Gastric Cancer through Down-Regulation of COX-2 and NF- kappaB Signaling Pathways.	Fluorouracil	43-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-113
29151957-11	2017	Furthermore, the protein expressions of COX-2 and NF-kappaB in MKN45 cells were decreased by 44.79% and 37.67%, 47.17% and 48.21%, 60.21% and 62.44%, respectively, after treatment of curcumin (25 mumol/l) and 5-FU (50 mumol/l) alone or in combination for 48 h. Curcumin also enhanced the anticancer activity of 5-FU without increasing toxicity in nude mice bearing MKN45 tumor xenografts in vivo.	Curcumin	183-191	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
29151957-11	2017	Furthermore, the protein expressions of COX-2 and NF-kappaB in MKN45 cells were decreased by 44.79% and 37.67%, 47.17% and 48.21%, 60.21% and 62.44%, respectively, after treatment of curcumin (25 mumol/l) and 5-FU (50 mumol/l) alone or in combination for 48 h. Curcumin also enhanced the anticancer activity of 5-FU without increasing toxicity in nude mice bearing MKN45 tumor xenografts in vivo.	Fluorouracil	209-213	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
29151957-11	2017	Furthermore, the protein expressions of COX-2 and NF-kappaB in MKN45 cells were decreased by 44.79% and 37.67%, 47.17% and 48.21%, 60.21% and 62.44%, respectively, after treatment of curcumin (25 mumol/l) and 5-FU (50 mumol/l) alone or in combination for 48 h. Curcumin also enhanced the anticancer activity of 5-FU without increasing toxicity in nude mice bearing MKN45 tumor xenografts in vivo.	Curcumin	261-269	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
29151957-11	2017	Furthermore, the protein expressions of COX-2 and NF-kappaB in MKN45 cells were decreased by 44.79% and 37.67%, 47.17% and 48.21%, 60.21% and 62.44%, respectively, after treatment of curcumin (25 mumol/l) and 5-FU (50 mumol/l) alone or in combination for 48 h. Curcumin also enhanced the anticancer activity of 5-FU without increasing toxicity in nude mice bearing MKN45 tumor xenografts in vivo.	Fluorouracil	311-315	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
28968088-2	2017	Combined experimental and computational data suggest that the charge-neutral four-coordinate complexes are best formulated as Co(II) centers bound to closed-shell [OCO]2- dianions, of the general formula [(OCO)CoIIL] (where L is a solvent-derived MeCN or THF).	oco]2- dianions	164-179	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-132
28968088-2	2017	Combined experimental and computational data suggest that the charge-neutral four-coordinate complexes are best formulated as Co(II) centers bound to closed-shell [OCO]2- dianions, of the general formula [(OCO)CoIIL] (where L is a solvent-derived MeCN or THF).	acetonitrile	247-251	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-132
28968088-2	2017	Combined experimental and computational data suggest that the charge-neutral four-coordinate complexes are best formulated as Co(II) centers bound to closed-shell [OCO]2- dianions, of the general formula [(OCO)CoIIL] (where L is a solvent-derived MeCN or THF).	tetrahydrofuran	255-258	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-132
28968088-5	2017	The metal and ligand oxidation states of the monocationic complex are ambiguous; data are consistent with formulation as either [(SOCO)CoIII(THF)2]+ containing a closed-shell [SOCO]2- diphenolate ligand bound to a S = 1 Co(III) center, or [(SOCO )CoII(THF)2]+ with a low-spin Co(II) ion ferromagnetically coupled to monoanionic [SOCO ]- containing a single unpaired electron distributed across the [OCO] framework.	coiii(thf)2]+	135-148	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	276-282
28968088-6	2017	The dication is best described as [(SOCO0)CoII(THF)3]2+, with a single unpaired electron localized on the d7 Co(II) center and a doubly oxidized, charge-neutral, closed-shell SOCO0 ligand.	tetrahydrofuran	47-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-115
28651842-0	2017	Sulodexide prevents activation of the PLA2/COX-2/VEGF inflammatory pathway in human retinal endothelial cells by blocking the effect of AGE/RAGE.	glucuronyl glucosamine glycan sulfate	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
28651842-2	2017	We tested the hypothesis that sulodexide (SDX), a highly purified glycosaminoglycan composed of 80% iduronylglycosaminoglycan sulfate and 20% dermatan sulfate, protects human retinal endothelial cells (HREC) from high glucose (HG)-induced damage, through the suppression of inflammatory ERK/cPLA2/COX-2/PGE2 pathway, by blocking the effect of advanced glycation end-products (AGEs).	glucuronyl glucosamine glycan sulfate	30-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	297-302
28651842-2	2017	We tested the hypothesis that sulodexide (SDX), a highly purified glycosaminoglycan composed of 80% iduronylglycosaminoglycan sulfate and 20% dermatan sulfate, protects human retinal endothelial cells (HREC) from high glucose (HG)-induced damage, through the suppression of inflammatory ERK/cPLA2/COX-2/PGE2 pathway, by blocking the effect of advanced glycation end-products (AGEs).	glucuronyl glucosamine glycan sulfate	42-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	297-302
28651842-9	2017	These data show that SDX protects HREC from HG damage and suggest that it counteracts the activation of ERK/cPLA2/COX-2/PGE2 pathway by reducing AGE-related signaling and downstream NFkappaB activity.	glucuronyl glucosamine glycan sulfate	21-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-119
28651842-9	2017	These data show that SDX protects HREC from HG damage and suggest that it counteracts the activation of ERK/cPLA2/COX-2/PGE2 pathway by reducing AGE-related signaling and downstream NFkappaB activity.	Dinoprostone	120-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-119
28916158-5	2017	Interestingly, the most potent compound in MTT assay, compound 12b, exhibited high inhibitory activity against COX-2 with selectivity index (COX-1/COX-2)&gt;100.	monooxyethylene trimethylolpropane tristearate	43-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	111-116
28933477-1	2017	We present a new and efficient cobalt precursor, CoII(DMOCHCOCF3)2, to prepare Co3O4 thin films and conformal coatings.	Cobalt	31-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-53
28933477-1	2017	We present a new and efficient cobalt precursor, CoII(DMOCHCOCF3)2, to prepare Co3O4 thin films and conformal coatings.	co3o4	79-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-53
28953394-8	2017	In situ XANES experiments under photocatalytic conditions show that the {CoII4O4} core undergoes oxidation to Co(III) or higher valent states, which recover rather slowly to Co(II).	xanes	8-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	174-180
28953394-8	2017	In situ XANES experiments under photocatalytic conditions show that the {CoII4O4} core undergoes oxidation to Co(III) or higher valent states, which recover rather slowly to Co(II).	coii4o4	73-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	174-180
28953394-9	2017	Complementary ex situ chemical oxidation experiments with [Ru(bpy)3]3+ furthermore indicate that the oxidation of all Co(II) centers of Co4O4-dpk to Co(III) is not a mandatory prerequisite for oxygen evolution.	co4o4	136-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-124
28766619-2	2017	In addition, reactions effective with NHC ligands are often ineffective with phosphine ligands, further motivating the evaluation of the fundamental electronic structure and bonding differences in well-defined distorted tetrahedral Co(ii) complexes.	phosphine	77-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	232-238
28771266-1	2017	Herein, a bis-amido tris-amine macrocycle and five bipyridine-based bidentate chelating ligands were investigated towards various divalent transition metal ion (NiII, CoII, CuII, and ZnII)-templated syntheses of metallo [2]pseudorotaxanes.	bis-amido tris-amine	10-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	167-171
28771266-3	2017	Azide-terminated NiII, CoII, CuII, ZnII-templated [2]pseudorotaxanes were explored to generate [2]rotaxane, ROT, via reaction with an alkyne-terminated triphenylene unit as a stopper under the mild reaction condition of the CuI-catalyzed azide-alkyne cycloaddition reaction.	Azides	0-5	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-27
28771266-3	2017	Azide-terminated NiII, CoII, CuII, ZnII-templated [2]pseudorotaxanes were explored to generate [2]rotaxane, ROT, via reaction with an alkyne-terminated triphenylene unit as a stopper under the mild reaction condition of the CuI-catalyzed azide-alkyne cycloaddition reaction.	[2]pseudorotaxanes	50-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-27
28771266-3	2017	Azide-terminated NiII, CoII, CuII, ZnII-templated [2]pseudorotaxanes were explored to generate [2]rotaxane, ROT, via reaction with an alkyne-terminated triphenylene unit as a stopper under the mild reaction condition of the CuI-catalyzed azide-alkyne cycloaddition reaction.	Alkynes	134-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-27
28771266-3	2017	Azide-terminated NiII, CoII, CuII, ZnII-templated [2]pseudorotaxanes were explored to generate [2]rotaxane, ROT, via reaction with an alkyne-terminated triphenylene unit as a stopper under the mild reaction condition of the CuI-catalyzed azide-alkyne cycloaddition reaction.	triphenylene	152-164	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-27
28771266-3	2017	Azide-terminated NiII, CoII, CuII, ZnII-templated [2]pseudorotaxanes were explored to generate [2]rotaxane, ROT, via reaction with an alkyne-terminated triphenylene unit as a stopper under the mild reaction condition of the CuI-catalyzed azide-alkyne cycloaddition reaction.	Azides	238-243	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-27
28771266-3	2017	Azide-terminated NiII, CoII, CuII, ZnII-templated [2]pseudorotaxanes were explored to generate [2]rotaxane, ROT, via reaction with an alkyne-terminated triphenylene unit as a stopper under the mild reaction condition of the CuI-catalyzed azide-alkyne cycloaddition reaction.	Alkynes	244-250	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-27
28993951-0	2017	Dinuclear adducts of di-o-iminoquinone ligands with CoII diketonates: computational insights into two-step valence tautomeric rearrangements.	di-o-iminoquinone	21-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-56
28993951-1	2017	Density functional theory (DFT) computational modeling [B3LYP*/6-311++G(d,p)] of a series of potentially valence tautomeric (VT) dinuclear 2:1 adducts of CoII bis-acetylacetonate, bis-trifluoroacetylacetonate and bis-hexafluoroacetylacetonate with redox-active tetradentate di-o-iminoquinone ligands has been performed.	dinuclear	129-138	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	154-158
28993951-1	2017	Density functional theory (DFT) computational modeling [B3LYP*/6-311++G(d,p)] of a series of potentially valence tautomeric (VT) dinuclear 2:1 adducts of CoII bis-acetylacetonate, bis-trifluoroacetylacetonate and bis-hexafluoroacetylacetonate with redox-active tetradentate di-o-iminoquinone ligands has been performed.	bis-trifluoroacetylacetonate	180-208	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	154-158
28993951-1	2017	Density functional theory (DFT) computational modeling [B3LYP*/6-311++G(d,p)] of a series of potentially valence tautomeric (VT) dinuclear 2:1 adducts of CoII bis-acetylacetonate, bis-trifluoroacetylacetonate and bis-hexafluoroacetylacetonate with redox-active tetradentate di-o-iminoquinone ligands has been performed.	bis-hexafluoroacetylacetonate	213-242	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	154-158
28993951-1	2017	Density functional theory (DFT) computational modeling [B3LYP*/6-311++G(d,p)] of a series of potentially valence tautomeric (VT) dinuclear 2:1 adducts of CoII bis-acetylacetonate, bis-trifluoroacetylacetonate and bis-hexafluoroacetylacetonate with redox-active tetradentate di-o-iminoquinone ligands has been performed.	di-o-iminoquinone	274-291	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	154-158
28993951-3	2017	Electron-withdrawing CF3-groups in the diketonate moiety of the mixed-ligand complexes promote narrowing of the energy gaps between the electronic states, which allows one-step VT rearrangements to be expected in the adducts of CoII bis-trifluoromethylacetylacetonate.	diketonate	39-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	228-232
28837331-2	2017	The feasibility of the magnetophoretic mole-ratio method was studied for the determination of the stoichiometry of the complexes formed between a hydrophobic phosphate ligand adsorbed in mesoporous hydrophobic silica particles and paramagnetic metal ions of Co(II), Tb(III), and Dy(III) in aqueous solutions.	Phosphates	158-167	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	258-264
28881160-11	2017	Genetic testing reported the presence of a p.T41A mutations on the CTNNB1 gene, which predicted that he is sensitive to the COX-2 inhibitor celecoxib.	Celecoxib	140-149	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	124-129
28801962-1	2017	The CoII and FeII complexes 1Co and 1Fe with a coordinated phosphorus radical were easily obtained through a charge-transfer approach from the MI precursors LMI (tol) (M=Co, Fe; L=CH(MeC=NDipp)2 , Dipp=2,6-iPr2 C6 H3 ) to the diazafluorenylidene-substituted phosphaalkene 1.	phosphorus radical	59-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-8
28801962-1	2017	The CoII and FeII complexes 1Co and 1Fe with a coordinated phosphorus radical were easily obtained through a charge-transfer approach from the MI precursors LMI (tol) (M=Co, Fe; L=CH(MeC=NDipp)2 , Dipp=2,6-iPr2 C6 H3 ) to the diazafluorenylidene-substituted phosphaalkene 1.	ndipp	187-192	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-8
28801962-1	2017	The CoII and FeII complexes 1Co and 1Fe with a coordinated phosphorus radical were easily obtained through a charge-transfer approach from the MI precursors LMI (tol) (M=Co, Fe; L=CH(MeC=NDipp)2 , Dipp=2,6-iPr2 C6 H3 ) to the diazafluorenylidene-substituted phosphaalkene 1.	1,3-di(4-imidazolinophenoxyl)propane	188-192	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-8
28801962-1	2017	The CoII and FeII complexes 1Co and 1Fe with a coordinated phosphorus radical were easily obtained through a charge-transfer approach from the MI precursors LMI (tol) (M=Co, Fe; L=CH(MeC=NDipp)2 , Dipp=2,6-iPr2 C6 H3 ) to the diazafluorenylidene-substituted phosphaalkene 1.	diazafluorenylidene	226-245	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-8
28801962-1	2017	The CoII and FeII complexes 1Co and 1Fe with a coordinated phosphorus radical were easily obtained through a charge-transfer approach from the MI precursors LMI (tol) (M=Co, Fe; L=CH(MeC=NDipp)2 , Dipp=2,6-iPr2 C6 H3 ) to the diazafluorenylidene-substituted phosphaalkene 1.	phosphaalkene	258-271	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-8
28915022-7	2017	In contrast, the magnetic behavior of 2 is dominated at low temperature by the CoII ion which connects the antiferromagnetically coupled {CoII4} helical moieties.	coii4	138-143	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-83
28841752-4	2017	Further mechanistic study and theoretical modeling indicate that the fully utilized Co(II)/Ni(II) active sites, efficient charge transfer, and favorable kinetics guarantee the efficient activities.	Nickel(2+)	91-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-90
28353025-7	2017	The traditional NSAIDs (i.e., meloxicam, etodolac, and nabumetone) have significant COX-2 specificity, but naproxen and ibuprofen have less specificity.	Meloxicam	30-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-89
28353025-7	2017	The traditional NSAIDs (i.e., meloxicam, etodolac, and nabumetone) have significant COX-2 specificity, but naproxen and ibuprofen have less specificity.	Etodolac	41-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-89
28353025-7	2017	The traditional NSAIDs (i.e., meloxicam, etodolac, and nabumetone) have significant COX-2 specificity, but naproxen and ibuprofen have less specificity.	Nabumetone	55-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-89
28647573-6	2017	In contrast, the FAK inhibitor PF-562271 blocked COX2 induction, implicating focal adhesions as critical sensory components upstream of this key immunomodulatory factor.	PF-562271	31-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-53
28772160-4	2017	The obtained results revealed that the benzothiazolopyrazolone derivative 13c was the most potent COX-2 inhibitor (IC50=0.10muM), while the 5-acetylbenzimidazolylpyrazolone derivative 12a was the most COX-2 selective (S.I.=104.67) in comparison with celecoxib (COX-2 IC50=1.11muM, S.I.=13.33).	13c	74-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-103
28772160-4	2017	The obtained results revealed that the benzothiazolopyrazolone derivative 13c was the most potent COX-2 inhibitor (IC50=0.10muM), while the 5-acetylbenzimidazolylpyrazolone derivative 12a was the most COX-2 selective (S.I.=104.67) in comparison with celecoxib (COX-2 IC50=1.11muM, S.I.=13.33).	13c	74-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	201-206
28772160-4	2017	The obtained results revealed that the benzothiazolopyrazolone derivative 13c was the most potent COX-2 inhibitor (IC50=0.10muM), while the 5-acetylbenzimidazolylpyrazolone derivative 12a was the most COX-2 selective (S.I.=104.67) in comparison with celecoxib (COX-2 IC50=1.11muM, S.I.=13.33).	13c	74-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	201-206
28772160-4	2017	The obtained results revealed that the benzothiazolopyrazolone derivative 13c was the most potent COX-2 inhibitor (IC50=0.10muM), while the 5-acetylbenzimidazolylpyrazolone derivative 12a was the most COX-2 selective (S.I.=104.67) in comparison with celecoxib (COX-2 IC50=1.11muM, S.I.=13.33).	5-acetylbenzimidazolylpyrazolone	140-172	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	201-206
28772160-4	2017	The obtained results revealed that the benzothiazolopyrazolone derivative 13c was the most potent COX-2 inhibitor (IC50=0.10muM), while the 5-acetylbenzimidazolylpyrazolone derivative 12a was the most COX-2 selective (S.I.=104.67) in comparison with celecoxib (COX-2 IC50=1.11muM, S.I.=13.33).	5-acetylbenzimidazolylpyrazolone	140-172	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	201-206
28803372-9	2017	The addition of a transition metal as catalyst, such as Fe(II) or Co(II), increased considerably the TOC removal efficiency higher than 50%, but not in all cases.	Metals	29-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-72
28709031-0	2017	Bisphenol A induces COX-2 through the mitogen-activated protein kinase pathway and is associated with levels of inflammation-related markers in elderly populations.	bisphenol A	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-25
28709031-4	2017	BPA induced COX-2 expression via nuclear translocation of NF-kappaB and activation of mitogen-activated protein kinase (MAPK) by phosphorylation of ERK1/2 and enhanced the migration of lung cancer A549 and breast cancer MDAMB-231 cells.	bisphenol A	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-17
28608598-6	2017	It also induced expression of COX-2 and TNF-alpha mRNA in a dose-dependent manner in phorbol 12-myristate 13-acetate differentiated THP-1 cells, which play a crucial role during inflammation.	Tetradecanoylphorbol Acetate	85-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-35
29076755-5	2017	CONCLUSION: In addition, docking study of the most potent and selective compound 12h into COX-2 active site revealed that this target compound assumed interactions and binding pattern similar to that of as a cocrystallized ligand bromocelecoxib (S-58).	12-hydroxydodecanoic acid	81-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-95
29076755-5	2017	CONCLUSION: In addition, docking study of the most potent and selective compound 12h into COX-2 active site revealed that this target compound assumed interactions and binding pattern similar to that of as a cocrystallized ligand bromocelecoxib (S-58).	bromocelecoxib	230-244	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-95
28849163-0	2017	Melatonin potentiates the antitumor effect of curcumin by inhibiting IKKbeta/NF-kappaB/COX-2 signaling pathway.	Melatonin	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-92
28849163-0	2017	Melatonin potentiates the antitumor effect of curcumin by inhibiting IKKbeta/NF-kappaB/COX-2 signaling pathway.	Curcumin	46-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-92
28676971-6	2017	Elevated ROS also increased the expression of COX-2 and APE1 enzymes and pretreatment of Curcumin and Quercetin decreased COX-2 expression and increased APE1 expression in the oxidatively stressed U-87 MG cells.	Reactive Oxygen Species	9-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
28444871-5	2017	Further studies indicated that DCS down-regulated phosphorylation of JNK, p38, and NF-kappaB in NCI-H460 cells and tumours and suppressed the IkappaB and COX-2 expression.	Cycloserine	31-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	154-159
28444871-7	2017	Inhibition of p38 activation by DCS was a likely contributing factor in IL-1 and COX-2 down-regulation.	Cycloserine	32-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-86
29375050-12	2017	ATB-346 but not naproxen decreased COX-2 protein expression in gastric mucosa compromised by WRS (p &lt; 0.05).	4-anisyltetrazolium blue	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40
29375050-16	2017	In contrast to naproxen, ATB-346 decreased stress-induced systemic inflammation and pro-inflammatory COX-2 expression in the gastric mucosa.	4-anisyltetrazolium blue	25-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-106
28676971-6	2017	Elevated ROS also increased the expression of COX-2 and APE1 enzymes and pretreatment of Curcumin and Quercetin decreased COX-2 expression and increased APE1 expression in the oxidatively stressed U-87 MG cells.	Curcumin	89-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-127
28676971-6	2017	Elevated ROS also increased the expression of COX-2 and APE1 enzymes and pretreatment of Curcumin and Quercetin decreased COX-2 expression and increased APE1 expression in the oxidatively stressed U-87 MG cells.	Quercetin	102-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-127
28937969-1	2017	This work presented a facile and eco-friendly method for the determination of cobalt ions (Co(II)) in living cells based on layered double hydroxides (Mg-Al CO3-LDHs) enhanced chemiluminescence (CL) emission of a Co(II)-hydrogen peroxide-sodium hydroxide system.	Cobalt	78-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-97
28945110-10	2017	COX-2 inhibition resulted in lower expression of obesity-induced TAM markers.	tam	65-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
28945110-11	2017	Our data suggest that obesity promotes macrophage infiltration into the prostate tumor microenvironment, and induces TAM polarization through the COX-2/PGE2 pathway.	tam	117-120	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	146-151
28945110-11	2017	Our data suggest that obesity promotes macrophage infiltration into the prostate tumor microenvironment, and induces TAM polarization through the COX-2/PGE2 pathway.	Dinoprostone	152-156	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	146-151
28951072-0	2017	Introduction of beta-d-mannuronic acid (M2000) as a novel NSAID with immunosuppressive property based on COX-1/COX-2 activity and gene expression.	mannuronic acid	16-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	111-116
28951072-4	2017	This study aimed to study the effects of beta-d-mannuronic (M2000) acid on the gene expression and activity of COX-1/COX-2 enzymes in order to introduce a novel NSAID for treating inflammatory diseases.	beta-d-mannuronic	41-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-122
28841774-6	2017	Significantly, switching of the monolayers consisting of supramolecular Co(II) metallopolymer bearing trans-azoaryl units to a novel pattern based on cis isomers can be triggered by UV light and reversed back to the trans conformer by using visible light, thereby restoring the trans-based supramolecular 2D packing.	trans-azoaryl	102-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-78
28539261-4	2017	Succinate-mediated GPR91 activation upregulates vascular endothelial growth factor (VEGF) through ERK1/2-C/EBP beta (c-Fos) and/or ERK1/2-COX-2/PGE2 signaling pathways, which in turn, leads to the breakdown of blood-retina barriers in these disorders.	Succinic Acid	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	138-143
29070119-2	2017	METHODS: After the treatment of NS-398 combined with BOR, MTT assay was used to detect the proliferation inhibition effect on human multiply myeloma RPMI 8226 cells in vitro, Flow cytometry was used to analyze their effect of apoptosis and cell cycle; the caspase-3 activity of different treatment group was detected by using ELISA and the activity of Cox-2 was measured by using Cox-2 activity assay kit.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	32-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	352-357
29070119-2	2017	METHODS: After the treatment of NS-398 combined with BOR, MTT assay was used to detect the proliferation inhibition effect on human multiply myeloma RPMI 8226 cells in vitro, Flow cytometry was used to analyze their effect of apoptosis and cell cycle; the caspase-3 activity of different treatment group was detected by using ELISA and the activity of Cox-2 was measured by using Cox-2 activity assay kit.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	32-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	380-385
28937969-1	2017	This work presented a facile and eco-friendly method for the determination of cobalt ions (Co(II)) in living cells based on layered double hydroxides (Mg-Al CO3-LDHs) enhanced chemiluminescence (CL) emission of a Co(II)-hydrogen peroxide-sodium hydroxide system.	Cobalt	78-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	213-219
28937969-1	2017	This work presented a facile and eco-friendly method for the determination of cobalt ions (Co(II)) in living cells based on layered double hydroxides (Mg-Al CO3-LDHs) enhanced chemiluminescence (CL) emission of a Co(II)-hydrogen peroxide-sodium hydroxide system.	Hydroxides	139-149	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-97
28937969-1	2017	This work presented a facile and eco-friendly method for the determination of cobalt ions (Co(II)) in living cells based on layered double hydroxides (Mg-Al CO3-LDHs) enhanced chemiluminescence (CL) emission of a Co(II)-hydrogen peroxide-sodium hydroxide system.	mg-al	151-156	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-97
28937969-1	2017	This work presented a facile and eco-friendly method for the determination of cobalt ions (Co(II)) in living cells based on layered double hydroxides (Mg-Al CO3-LDHs) enhanced chemiluminescence (CL) emission of a Co(II)-hydrogen peroxide-sodium hydroxide system.	mg-al	151-156	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	213-219
28937969-1	2017	This work presented a facile and eco-friendly method for the determination of cobalt ions (Co(II)) in living cells based on layered double hydroxides (Mg-Al CO3-LDHs) enhanced chemiluminescence (CL) emission of a Co(II)-hydrogen peroxide-sodium hydroxide system.	co3	157-160	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-97
28937969-1	2017	This work presented a facile and eco-friendly method for the determination of cobalt ions (Co(II)) in living cells based on layered double hydroxides (Mg-Al CO3-LDHs) enhanced chemiluminescence (CL) emission of a Co(II)-hydrogen peroxide-sodium hydroxide system.	Hydrogen Peroxide	220-237	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-97
28937969-1	2017	This work presented a facile and eco-friendly method for the determination of cobalt ions (Co(II)) in living cells based on layered double hydroxides (Mg-Al CO3-LDHs) enhanced chemiluminescence (CL) emission of a Co(II)-hydrogen peroxide-sodium hydroxide system.	Sodium Hydroxide	238-254	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-97
28937969-3	2017	The proposed method displayed high selectivity toward Co(II) over other metal ions.	Metals	72-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-60
29163789-5	2017	The disruption of COX2/PGE2 signaling using COX2 inhibitors or PGE2 receptors EP2 and EP4 antagonists, combined with anti-PD-1 blockade was therapeutic in terms of improving eradication of tumors and augmenting the numbers of functional tumor-specific CTLs.	Dinoprostone	23-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-48
29163789-6	2017	Thus, COX2/PGE2 axis inhibition is a promising adjunct therapy to PD-1 blockade for immune-based therapies in cancer.	Dinoprostone	11-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	6-10
28852749-2	2017	The coordination polyhedron of the Co(ii) cations is a distorted octahedron built from two N and two S atoms of four equatorial NCS anions and two apical N atoms of the pyridine ligands.	octahedron	65-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-41
28852749-2	2017	The coordination polyhedron of the Co(ii) cations is a distorted octahedron built from two N and two S atoms of four equatorial NCS anions and two apical N atoms of the pyridine ligands.	pyridine	169-177	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-41
28925958-0	2017	Spiropyran-Isoquinoline Dyad as a Dual Chemosensor for Co(II) and In(III) Detection.	spiropyran-isoquinoline	0-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-61
28925958-0	2017	Spiropyran-Isoquinoline Dyad as a Dual Chemosensor for Co(II) and In(III) Detection.	dyad	24-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-61
29086874-0	2017	Reversible uptake of molecular oxygen by heteroligand Co(II)-L-alpha-amino acid-imidazole systems: equilibrium models at full mass balance.	Oxygen	31-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-60
29086874-1	2017	BACKGROUND: The paper examines Co(II)-amino acid-imidazole systems (where amino acid = L-alpha-amino acid: alanine, asparagine, histidine) which, when in aqueous solutions, activate and reversibly take up dioxygen, while maintaining the structural scheme of the heme group (imidazole as axial ligand and O2 uptake at the sixth, trans position) thus imitating natural respiratory pigments such as myoglobin and hemoglobin.	imidazole	49-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-37
29086874-1	2017	BACKGROUND: The paper examines Co(II)-amino acid-imidazole systems (where amino acid = L-alpha-amino acid: alanine, asparagine, histidine) which, when in aqueous solutions, activate and reversibly take up dioxygen, while maintaining the structural scheme of the heme group (imidazole as axial ligand and O2 uptake at the sixth, trans position) thus imitating natural respiratory pigments such as myoglobin and hemoglobin.	Amino Acids	87-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-37
29086874-1	2017	BACKGROUND: The paper examines Co(II)-amino acid-imidazole systems (where amino acid = L-alpha-amino acid: alanine, asparagine, histidine) which, when in aqueous solutions, activate and reversibly take up dioxygen, while maintaining the structural scheme of the heme group (imidazole as axial ligand and O2 uptake at the sixth, trans position) thus imitating natural respiratory pigments such as myoglobin and hemoglobin.	Alanine	107-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-37
29086874-1	2017	BACKGROUND: The paper examines Co(II)-amino acid-imidazole systems (where amino acid = L-alpha-amino acid: alanine, asparagine, histidine) which, when in aqueous solutions, activate and reversibly take up dioxygen, while maintaining the structural scheme of the heme group (imidazole as axial ligand and O2 uptake at the sixth, trans position) thus imitating natural respiratory pigments such as myoglobin and hemoglobin.	Asparagine	116-126	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-37
29086874-1	2017	BACKGROUND: The paper examines Co(II)-amino acid-imidazole systems (where amino acid = L-alpha-amino acid: alanine, asparagine, histidine) which, when in aqueous solutions, activate and reversibly take up dioxygen, while maintaining the structural scheme of the heme group (imidazole as axial ligand and O2 uptake at the sixth, trans position) thus imitating natural respiratory pigments such as myoglobin and hemoglobin.	Histidine	128-137	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-37
29086874-1	2017	BACKGROUND: The paper examines Co(II)-amino acid-imidazole systems (where amino acid = L-alpha-amino acid: alanine, asparagine, histidine) which, when in aqueous solutions, activate and reversibly take up dioxygen, while maintaining the structural scheme of the heme group (imidazole as axial ligand and O2 uptake at the sixth, trans position) thus imitating natural respiratory pigments such as myoglobin and hemoglobin.	Oxygen	205-213	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-37
28849635-1	2017	A Co(II) complex, [Co(L)2]Cl2, 1 of the ligand L (L = bis(2-ethyl-4-methylimidazol-5-yl)methane) upon reaction with H2O2 in methanol solution at -40  C resulted in the formation of the corresponding Co(III)-peroxo complex [Co(L)2(O2)]+ (2).	[co(l)2]cl2	18-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	2-8
28849635-1	2017	A Co(II) complex, [Co(L)2]Cl2, 1 of the ligand L (L = bis(2-ethyl-4-methylimidazol-5-yl)methane) upon reaction with H2O2 in methanol solution at -40  C resulted in the formation of the corresponding Co(III)-peroxo complex [Co(L)2(O2)]+ (2).	bis(2-ethyl-4-methylimidazol-5-yl)methane	54-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	2-8
28849635-1	2017	A Co(II) complex, [Co(L)2]Cl2, 1 of the ligand L (L = bis(2-ethyl-4-methylimidazol-5-yl)methane) upon reaction with H2O2 in methanol solution at -40  C resulted in the formation of the corresponding Co(III)-peroxo complex [Co(L)2(O2)]+ (2).	Hydrogen Peroxide	116-120	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	2-8
28849635-1	2017	A Co(II) complex, [Co(L)2]Cl2, 1 of the ligand L (L = bis(2-ethyl-4-methylimidazol-5-yl)methane) upon reaction with H2O2 in methanol solution at -40  C resulted in the formation of the corresponding Co(III)-peroxo complex [Co(L)2(O2)]+ (2).	Methanol	124-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	2-8
28849635-1	2017	A Co(II) complex, [Co(L)2]Cl2, 1 of the ligand L (L = bis(2-ethyl-4-methylimidazol-5-yl)methane) upon reaction with H2O2 in methanol solution at -40  C resulted in the formation of the corresponding Co(III)-peroxo complex [Co(L)2(O2)]+ (2).	co(iii)-peroxo	199-213	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	2-8
29086874-1	2017	BACKGROUND: The paper examines Co(II)-amino acid-imidazole systems (where amino acid = L-alpha-amino acid: alanine, asparagine, histidine) which, when in aqueous solutions, activate and reversibly take up dioxygen, while maintaining the structural scheme of the heme group (imidazole as axial ligand and O2 uptake at the sixth, trans position) thus imitating natural respiratory pigments such as myoglobin and hemoglobin.	Heme	250-254	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-37
28849635-1	2017	A Co(II) complex, [Co(L)2]Cl2, 1 of the ligand L (L = bis(2-ethyl-4-methylimidazol-5-yl)methane) upon reaction with H2O2 in methanol solution at -40  C resulted in the formation of the corresponding Co(III)-peroxo complex [Co(L)2(O2)]+ (2).	co(l)2(o2)	223-233	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	2-8
29086874-1	2017	BACKGROUND: The paper examines Co(II)-amino acid-imidazole systems (where amino acid = L-alpha-amino acid: alanine, asparagine, histidine) which, when in aqueous solutions, activate and reversibly take up dioxygen, while maintaining the structural scheme of the heme group (imidazole as axial ligand and O2 uptake at the sixth, trans position) thus imitating natural respiratory pigments such as myoglobin and hemoglobin.	imidazole	274-283	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-37
29086874-1	2017	BACKGROUND: The paper examines Co(II)-amino acid-imidazole systems (where amino acid = L-alpha-amino acid: alanine, asparagine, histidine) which, when in aqueous solutions, activate and reversibly take up dioxygen, while maintaining the structural scheme of the heme group (imidazole as axial ligand and O2 uptake at the sixth, trans position) thus imitating natural respiratory pigments such as myoglobin and hemoglobin.	Oxygen	304-306	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-37
28862848-0	2017	Enantioselective Aldol Reactions in Water by a Proline-Derived Cryptand and Fixation of CO2 by Its Exocyclic Co(II) Complex.	Water	36-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-115
29086874-2	2017	The oxygenated reaction shows higher reversibility than for Co(II)-amac systems with analogous amino acids without imidazole.	imidazole	115-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-66
28862848-0	2017	Enantioselective Aldol Reactions in Water by a Proline-Derived Cryptand and Fixation of CO2 by Its Exocyclic Co(II) Complex.	Proline	47-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-115
28862848-0	2017	Enantioselective Aldol Reactions in Water by a Proline-Derived Cryptand and Fixation of CO2 by Its Exocyclic Co(II) Complex.	N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)-4-((4-fluorobenzyl)oxy)pyridine-2,6-dicarboxamide	88-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-115
29086874-3	2017	Unlike previous investigations of the heteroligand Co(II)-amino acid-imidazole systems, the present study accurately calculates all equilibrium forms present in solution and determines the [Formula: see text]equilibrium constants without using any simplified approximations.	amino acid-imidazole	58-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-57
28862848-2	2017	On reacting with Co(II) perchlorate in the presence of KSCN, L readily formed the trinuclear complex {[Co3(L)2(NCS)6] (15CH3CN)(5acetone)(6H2O)} (1).	potassium thiocyanate	55-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-23
28862848-2	2017	On reacting with Co(II) perchlorate in the presence of KSCN, L readily formed the trinuclear complex {[Co3(L)2(NCS)6] (15CH3CN)(5acetone)(6H2O)} (1).	[co3(l)2(ncs)6] (15ch3cn)(5acetone	102-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-23
29086874-7	2017	RESULTS: Investigations of oxygenation of the Co(II)-amino acid-imidazole systems indicated that dioxygen uptake proceeds along with a rise in pH to 9-10.	imidazole	64-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-52
28862848-2	2017	On reacting with Co(II) perchlorate in the presence of KSCN, L readily formed the trinuclear complex {[Co3(L)2(NCS)6] (15CH3CN)(5acetone)(6H2O)} (1).	6h2o)	138-143	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-23
29086874-7	2017	RESULTS: Investigations of oxygenation of the Co(II)-amino acid-imidazole systems indicated that dioxygen uptake proceeds along with a rise in pH to 9-10.	Oxygen	97-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-52
29086874-9	2017	Calculations of the share of the free Co(II) ion as well as of the particular complex species existing in solution beside the oxygen adduct (regarding dioxygen bound both reversibly and irreversibly) indicated quite significant values for the systems with alanine and asparagine-in those cases the of oxygenation reaction is right shifted to a relatively lower extent.	Alanine	256-263	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-44
29086874-14	2017	CONCLUSIONS: The Co(II)-amac-Himid systems formed by using a [Co(imid)2]n polymer as starting material demonstrate that the reversible uptake of molecular oxygen occurs by forming dimeric mu-peroxy adducts.	amac-himid	24-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-23
29086874-14	2017	CONCLUSIONS: The Co(II)-amac-Himid systems formed by using a [Co(imid)2]n polymer as starting material demonstrate that the reversible uptake of molecular oxygen occurs by forming dimeric mu-peroxy adducts.	[co(imid)2]n polymer	61-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-23
29086874-14	2017	CONCLUSIONS: The Co(II)-amac-Himid systems formed by using a [Co(imid)2]n polymer as starting material demonstrate that the reversible uptake of molecular oxygen occurs by forming dimeric mu-peroxy adducts.	Oxygen	155-161	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-23
29254155-4	2017	Casticin decreased levels of IL-6, tumor necrosis factor alpha, and IL-8 and suppressed COX-2 expression and prostaglandin E2 production.	casticin	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-93
29152087-10	2017	Consistently, the COX-2 inhibitor Celecoxib blocked the invasive phenotype induced by the Rho-activating toxins.	Celecoxib	34-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-23
29066864-8	2017	The pharmacodynamic analysis revealed that the maximum effect of COX-2 inhibition was achieved at 2.0 hours for all genotypes of COX-2 SNPs after a single oral administration of 200 mg celecoxib.	Celecoxib	185-194	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-70
28783434-6	2017	Further characterization of Co-MFU-4l by X-ray absorption spectroscopy provided evidence for discrete, tris-pyrazolylborate-like coordination of Co(II).	tris(pyrazolyl)borate	103-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-151
29066864-8	2017	The pharmacodynamic analysis revealed that the maximum effect of COX-2 inhibition was achieved at 2.0 hours for all genotypes of COX-2 SNPs after a single oral administration of 200 mg celecoxib.	Celecoxib	185-194	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-134
29066864-10	2017	CONCLUSION: Our results demonstrated that inhibitory effects of celecoxib on COX-2 induction were different according to the genotype of COX-2 SNPs.	Celecoxib	64-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-82
29066864-10	2017	CONCLUSION: Our results demonstrated that inhibitory effects of celecoxib on COX-2 induction were different according to the genotype of COX-2 SNPs.	Celecoxib	64-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-142
29066864-11	2017	In the present study, rs689466 is responsible for the variability of the response to celecoxib, suggesting that a subject with the GG genotype of rs689466 would be more responsive to celecoxib in terms of COX-2 inhibition.	Celecoxib	85-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	205-210
28812076-2	2017	The combination of [WZn3(H2O)2(ZnW9O34)2]12- and Co(ii) provides a synergistical catalytic way to promote oximation of aldehyde/ketone with in situ generated hydroxylamine that initially produces an oxime, which further either dehydrates into a nitrile or undergoes a Beckmann rearrangement to form an amide.	Aldehydes	119-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-55
28812076-2	2017	The combination of [WZn3(H2O)2(ZnW9O34)2]12- and Co(ii) provides a synergistical catalytic way to promote oximation of aldehyde/ketone with in situ generated hydroxylamine that initially produces an oxime, which further either dehydrates into a nitrile or undergoes a Beckmann rearrangement to form an amide.	Ketones	128-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-55
28812076-2	2017	The combination of [WZn3(H2O)2(ZnW9O34)2]12- and Co(ii) provides a synergistical catalytic way to promote oximation of aldehyde/ketone with in situ generated hydroxylamine that initially produces an oxime, which further either dehydrates into a nitrile or undergoes a Beckmann rearrangement to form an amide.	Hydroxylamine	158-171	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-55
28812076-2	2017	The combination of [WZn3(H2O)2(ZnW9O34)2]12- and Co(ii) provides a synergistical catalytic way to promote oximation of aldehyde/ketone with in situ generated hydroxylamine that initially produces an oxime, which further either dehydrates into a nitrile or undergoes a Beckmann rearrangement to form an amide.	Oximes	199-204	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-55
28812076-2	2017	The combination of [WZn3(H2O)2(ZnW9O34)2]12- and Co(ii) provides a synergistical catalytic way to promote oximation of aldehyde/ketone with in situ generated hydroxylamine that initially produces an oxime, which further either dehydrates into a nitrile or undergoes a Beckmann rearrangement to form an amide.	Nitriles	245-252	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-55
28812076-2	2017	The combination of [WZn3(H2O)2(ZnW9O34)2]12- and Co(ii) provides a synergistical catalytic way to promote oximation of aldehyde/ketone with in situ generated hydroxylamine that initially produces an oxime, which further either dehydrates into a nitrile or undergoes a Beckmann rearrangement to form an amide.	Amides	302-307	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-55
29066864-11	2017	In the present study, rs689466 is responsible for the variability of the response to celecoxib, suggesting that a subject with the GG genotype of rs689466 would be more responsive to celecoxib in terms of COX-2 inhibition.	Celecoxib	183-192	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	205-210
28525865-3	2017	This bidentate ligand coordinates three metal ions of Co(II), Cu(II) and Fe(II) via nitrogen and oxygen atoms.	Metals	40-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-60
28494375-1	2017	Nanosized (NS) cobalt (II) bis(5-phenyl-azo-8-hydroxyquinolate) (NS Co(II)-(5PA-8HQ)2) thin films have been synthesized using static step-by-step soft surface reaction (SS-b-SSR) technique.	cobalt (ii) bis(5-phenyl-azo-8-hydroxyquinolate)	15-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-73
28494375-3	2017	The HR-TEM results revealed that the assembled Co(II)-complex exhibited a uniformly NS structure particles in the form of nanorods with width and length up to 16.90nm and 506.38nm, respectively.	ns	84-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
28650862-2	2017	Celecoxib (Cel) is a COX-2-selective nonsteroidal anti-inflammatory drug and its antitumoral effect has been shown widely in a variety of cancers including OS cells in vitro.	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-26
28650862-2	2017	Celecoxib (Cel) is a COX-2-selective nonsteroidal anti-inflammatory drug and its antitumoral effect has been shown widely in a variety of cancers including OS cells in vitro.	Celecoxib	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-26
28759712-9	2017	Results suggest that nonpeptide hormones inhibit resveratrol-induced antiproliferation in cancer cells downstream of the interaction between ligand and receptor and ERK1/2 activation to interfere with nuclear COX-2 accumulation.	Resveratrol	49-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	209-214
28593792-2	2017	The method is based on the catalytic effect of Co(II) on the Tiron oxidation by hydrogen peroxide in alkaline medium, forming a complex that absorbs radiation at 425 nm.	1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt	61-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-53
28593792-2	2017	The method is based on the catalytic effect of Co(II) on the Tiron oxidation by hydrogen peroxide in alkaline medium, forming a complex that absorbs radiation at 425 nm.	Hydrogen Peroxide	80-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-53
28757100-3	2017	Among them, the inhibitory activity of compound 1h to COX-2 was IC50=0.049mumol/L and SI &gt;1000.	Hydrogen	48-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-59
28911173-9	2017	These results indicate that LiCl upregulates the expression of COX-2 and the subsequent production of PGE2 through the canonical GSK-3beta/beta-catenin signaling pathway in hGL cells.	Lithium Chloride	28-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-68
28911173-2	2017	Cyclooxygenase (COX)-2 and its derivative, prostaglandin E2 (PGE2), play regulatory roles in the human ovulatory process.	Dinoprostone	43-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-22
28911173-2	2017	Cyclooxygenase (COX)-2 and its derivative, prostaglandin E2 (PGE2), play regulatory roles in the human ovulatory process.	Dinoprostone	61-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-22
28759712-4	2017	Resveratrol induces inducible COX-2-dependent antiproliferation via integrin alphav beta3 .	Resveratrol	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-35
28759712-6	2017	Hormones inhibit resveratrol-stimulated phosphorylation of p53 on Ser15, resveratrol-induced nuclear COX-2 accumulation, and formation of p53-COX-2 nuclear complexes.	Resveratrol	17-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-106
28759712-6	2017	Hormones inhibit resveratrol-stimulated phosphorylation of p53 on Ser15, resveratrol-induced nuclear COX-2 accumulation, and formation of p53-COX-2 nuclear complexes.	Resveratrol	17-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	142-147
28759712-6	2017	Hormones inhibit resveratrol-stimulated phosphorylation of p53 on Ser15, resveratrol-induced nuclear COX-2 accumulation, and formation of p53-COX-2 nuclear complexes.	Resveratrol	73-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-106
28759712-7	2017	Subsequently, hormones impair resveratrol-induced COX-2-/p53-dependent gene expression.	Resveratrol	30-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-55
28677874-0	2017	Enantioresolution and stereochemical characterization of two chiral sulfoxides endowed with COX-2 inhibitory activity.	Sulfoxides	68-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-97
28677874-1	2017	The capacity of nonsteroidal antiinflammatory drugs (NSAIDs) to prevent prostanoids biosynthesis through the inhibition of COX-2 enzyme is related to their structural backbone, based on the fusion of a cis-stilbene unit with a variety of heterocyclic and carbocyclic rings.	Prostaglandins	72-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-128
28677874-1	2017	The capacity of nonsteroidal antiinflammatory drugs (NSAIDs) to prevent prostanoids biosynthesis through the inhibition of COX-2 enzyme is related to their structural backbone, based on the fusion of a cis-stilbene unit with a variety of heterocyclic and carbocyclic rings.	cis-Stilbene	202-214	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-128
28677874-2	2017	By this route, a series of new selective COX-2 inhibitors was developed, by maintaining the 4-methylsulfone or 4-methylsulfonamide substituent on the phenyl moiety, essential for their activity.	4-methylsulfone	92-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-46
28677874-2	2017	By this route, a series of new selective COX-2 inhibitors was developed, by maintaining the 4-methylsulfone or 4-methylsulfonamide substituent on the phenyl moiety, essential for their activity.	4-methylsulfonamide	111-130	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-46
28677874-3	2017	In this frame, two novel propyl sulfoxide derivatives were synthesized, which proved selective and sufficiently potent COX-2 inhibition activity when tested as racemates.	dipropyl sulfoxide	25-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-124
28444938-4	2017	mRNA and protein expressions of proliferation factors, such as cyclin D1, COX-2, and proliferating cell nuclear antigen (PCNA), increased in chronically exposed arsenite SV-HUC-1 cells with exposure time.	arsenite	161-169	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
28444938-6	2017	Knockdown of STAT3 reduced expressions of cyclin D1, COX-2, PCNA, and BCL2 induced by arsenite.	arsenite	86-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-58
28444938-7	2017	In conclusion, arsenic induced proliferation in human uroepithelial cells after short and long term exposure to arsenite and JAK2/STAT3 signaling pathway might be pivotal in arsenite-induced proliferation by regulating cyclin D1, COX-2, PCNA, and BCL2.	Arsenic	15-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	230-235
28444938-7	2017	In conclusion, arsenic induced proliferation in human uroepithelial cells after short and long term exposure to arsenite and JAK2/STAT3 signaling pathway might be pivotal in arsenite-induced proliferation by regulating cyclin D1, COX-2, PCNA, and BCL2.	arsenite	112-120	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	230-235
28444938-7	2017	In conclusion, arsenic induced proliferation in human uroepithelial cells after short and long term exposure to arsenite and JAK2/STAT3 signaling pathway might be pivotal in arsenite-induced proliferation by regulating cyclin D1, COX-2, PCNA, and BCL2.	arsenite	174-182	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	230-235
28911173-3	2017	Whether LiCl affects ovulation by regulating COX2 expression and PGE2 production in the human ovary is still largely unknown.	Lithium Chloride	8-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-49
28911173-4	2017	The aim of this study was to investigate the effect of LiCl on the expression of COX-2 and production of PGE2 in human granulosa-lutein (hGL) cells, as well as the mechanisms underlying this effect.	Lithium Chloride	55-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-86
28911173-8	2017	Furthermore, knockdown of either beta-catenin or GSK-3beta reversed the LiCl-induced upregulation of COX-2 expression.	Lithium Chloride	72-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-106
28525865-3	2017	This bidentate ligand coordinates three metal ions of Co(II), Cu(II) and Fe(II) via nitrogen and oxygen atoms.	ammonium ferrous sulfate	73-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-60
28525865-3	2017	This bidentate ligand coordinates three metal ions of Co(II), Cu(II) and Fe(II) via nitrogen and oxygen atoms.	Nitrogen	84-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-60
28525865-3	2017	This bidentate ligand coordinates three metal ions of Co(II), Cu(II) and Fe(II) via nitrogen and oxygen atoms.	Oxygen	97-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-60
28618389-5	2017	BFNM inhibited NO and PGE2 production in a concentration-dependent manner and down-regulated the expression of iNOS and COX-2 at mRNA and protein levels.	bfnm	0-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-125
28447182-1	2017	Two new Co(II) complexes of 4-((3-ethoxy-2-hydroxybenzylidene)amino)-N-(thiazol-2-yl)benzenesulphonamide and 4-((pyridin-2-ylmethylene)amino)-N-(thiazol-2-yl)benzene sulfonamide were synthesised.	4-((pyridin-2-ylmethylene)amino)-n-(thiazol-2-yl)benzene sulfonamide	109-177	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	8-14
28666239-9	2017	We found that CTS significantly inhibited the IL-1beta-induced production of NO and PGE2; expression of COX-2, iNOS, MMP-3, MMP-13, and ADAMTS-5.	cryptotanshinone	14-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
28883751-0	2017	Resveratrol raises in vitro anticancer effects of paclitaxel in NSCLC cell line A549 through COX-2 expression.	Resveratrol	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-98
28883751-0	2017	Resveratrol raises in vitro anticancer effects of paclitaxel in NSCLC cell line A549 through COX-2 expression.	Paclitaxel	50-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-98
28652177-5	2017	The results showed that glycyrrhizin significantly inhibited LPS-induced IL-6 and IL-8 production, as well as COX-2 and iNOS expression.	Glycyrrhizic Acid	24-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-115
28729223-3	2017	These polymeric Schiff base ligands, SBOPA and SBPBA generates polymeric metal complexes in high yields on reaction with transition metal acetates, M(CH3COO)2.xH2O where M = Mn(II), Co(II), Ni(II), Cu(II) and Zn(II).	Schiff Bases	16-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	182-188
28729223-3	2017	These polymeric Schiff base ligands, SBOPA and SBPBA generates polymeric metal complexes in high yields on reaction with transition metal acetates, M(CH3COO)2.xH2O where M = Mn(II), Co(II), Ni(II), Cu(II) and Zn(II).	sbopa	37-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	182-188
28729223-3	2017	These polymeric Schiff base ligands, SBOPA and SBPBA generates polymeric metal complexes in high yields on reaction with transition metal acetates, M(CH3COO)2.xH2O where M = Mn(II), Co(II), Ni(II), Cu(II) and Zn(II).	sbpba	47-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	182-188
28729223-3	2017	These polymeric Schiff base ligands, SBOPA and SBPBA generates polymeric metal complexes in high yields on reaction with transition metal acetates, M(CH3COO)2.xH2O where M = Mn(II), Co(II), Ni(II), Cu(II) and Zn(II).	Metals	73-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	182-188
28729223-3	2017	These polymeric Schiff base ligands, SBOPA and SBPBA generates polymeric metal complexes in high yields on reaction with transition metal acetates, M(CH3COO)2.xH2O where M = Mn(II), Co(II), Ni(II), Cu(II) and Zn(II).	metal acetates	132-146	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	182-188
28729223-3	2017	These polymeric Schiff base ligands, SBOPA and SBPBA generates polymeric metal complexes in high yields on reaction with transition metal acetates, M(CH3COO)2.xH2O where M = Mn(II), Co(II), Ni(II), Cu(II) and Zn(II).	(ch3coo)2.xh2o	149-163	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	182-188
28729223-3	2017	These polymeric Schiff base ligands, SBOPA and SBPBA generates polymeric metal complexes in high yields on reaction with transition metal acetates, M(CH3COO)2.xH2O where M = Mn(II), Co(II), Ni(II), Cu(II) and Zn(II).	Nickel(2+)	190-196	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	182-188
28729223-3	2017	These polymeric Schiff base ligands, SBOPA and SBPBA generates polymeric metal complexes in high yields on reaction with transition metal acetates, M(CH3COO)2.xH2O where M = Mn(II), Co(II), Ni(II), Cu(II) and Zn(II).	cu(ii)	198-204	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	182-188
28729223-3	2017	These polymeric Schiff base ligands, SBOPA and SBPBA generates polymeric metal complexes in high yields on reaction with transition metal acetates, M(CH3COO)2.xH2O where M = Mn(II), Co(II), Ni(II), Cu(II) and Zn(II).	Zinc	209-215	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	182-188
28729223-6	2017	On the basis of FT-IR, 1HNMR, electronic spectra and magnetic moment values Mn(II), Co(II) and Ni(II) ion were found to have octahedral geometry while Cu(II) and Zn(II) were found to be square-planar in nature.	cu(ii)	151-157	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-90
28729223-6	2017	On the basis of FT-IR, 1HNMR, electronic spectra and magnetic moment values Mn(II), Co(II) and Ni(II) ion were found to have octahedral geometry while Cu(II) and Zn(II) were found to be square-planar in nature.	Zinc	162-168	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-90
28733029-0	2017	Synthesis of Ni(II), Cu(II) and Co(II) complexes with new macrocyclic Schiff-base ligand containing dihydrazide moiety: Spectroscopic, structural, antimicrobial and antioxidant properties.	Nickel(2+)	13-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-38
28733029-0	2017	Synthesis of Ni(II), Cu(II) and Co(II) complexes with new macrocyclic Schiff-base ligand containing dihydrazide moiety: Spectroscopic, structural, antimicrobial and antioxidant properties.	Schiff Bases	70-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-38
28733029-0	2017	Synthesis of Ni(II), Cu(II) and Co(II) complexes with new macrocyclic Schiff-base ligand containing dihydrazide moiety: Spectroscopic, structural, antimicrobial and antioxidant properties.	dihydrazide	100-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-38
28733029-1	2017	In this study, the macrocyclic Schiff base ligand (L) derived from 1, 4-dicarbonyl-phenyl-dihydrazide and glyoxal (2:2) and its Ni (II), Cu (II) and Co(II) complexes were synthesised and were characterised by elemental analyses, FTIR, UV-Vis., mass and 1H NMR.	Schiff Bases	31-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	149-155
28733029-1	2017	In this study, the macrocyclic Schiff base ligand (L) derived from 1, 4-dicarbonyl-phenyl-dihydrazide and glyoxal (2:2) and its Ni (II), Cu (II) and Co(II) complexes were synthesised and were characterised by elemental analyses, FTIR, UV-Vis., mass and 1H NMR.	cu (ii)	137-144	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	149-155
28577050-0	2017	Anticonvulsive activity of (1S)-(-)-verbenone involving RNA expression of BDNF, COX-2, and c-fos.	verbenone	27-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-85
28577050-8	2017	Pretreatment with flumazenil (FLU) did not reverse the anticonvulsive effect of VRB; however, it was able to upregulate BDNF and COX-2 genes and downregulate c-fos.	Flumazenil	18-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-134
28577050-8	2017	Pretreatment with flumazenil (FLU) did not reverse the anticonvulsive effect of VRB; however, it was able to upregulate BDNF and COX-2 genes and downregulate c-fos.	Flumazenil	30-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-134
28108282-5	2017	Studies on glomerular podocytes, tubular epithelial cells and bone osteocytes provide evidence for a significant role of COX-2 generated PGE2 and its receptors in response to tensile stress and FFSS.	Dinoprostone	137-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-126
28528242-2	2017	Celecoxib, a nonsteroidal anti-inflammatory drug that acts via the selective inhibition of cyclooxygenase (COX)-2, has shown favorable effects in several psychiatric disorders.	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-113
28606428-4	2017	TiO2 particles at 10mug/ml showed increased mRNA expression of inflammatory cytokines (TNFalpha, IL-1beta and IL-6), inflammatory mediators (iNOS and COX-2) and transcription factor (NFkappaB) similar to that of LPS stimulated macrophages.	titanium dioxide	0-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	150-155
28826906-10	2017	Al increased SBP, decreased ACh-induced relaxation, increased response to Phe, decreased endothelial modulation of vasoconstrictor responses, the bioavailability of nitric oxide (NO), the involvement of potassium channels on vascular responses, as well as increased ROS production from NAD(P)H oxidase and contractile prostanoids mainly from COX-2 in both aorta and mesenteric arteries.	Aluminum	0-2	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	342-347
28826906-13	2017	Our results point to an excess of ROS mainly from NAD(P)H oxidase after Al exposure and the increased vascular prostanoids from COX-2 acting in concert to decrease NO bioavailability, thus inducing vascular dysfunction and increasing blood pressure.	Prostaglandins	111-122	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	128-133
28805866-1	2017	Using deprotonated forms of tridentate azo-containing pyridine-2-/pyrazine-2-carboxamide 2-[N-(2-phenylazo)carbamoyl]-pyridine/pyrazine, seven bis-ligand complexes of FeII/CoII and FeIII/CoIII have been synthesized.	azo-containing pyridine-2-/pyrazine-2-carboxamide 2-[n-(2-phenylazo)carbamoyl]-pyridine	39-126	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	172-176
28805866-1	2017	Using deprotonated forms of tridentate azo-containing pyridine-2-/pyrazine-2-carboxamide 2-[N-(2-phenylazo)carbamoyl]-pyridine/pyrazine, seven bis-ligand complexes of FeII/CoII and FeIII/CoIII have been synthesized.	Pyrazines	66-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	172-176
28851389-3	2017	METHODS: Between 2003 and 2015, 40 patients with extra-peritoneal sporadic DF were prospectively treated with meloxicam or celecoxib, a COX-2 inhibitor, therapy.	Celecoxib	123-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	136-141
28605076-1	2017	Three new closely related CoII YIII complexes of general formula [Co(mu-L)(mu-X)Y(NO3 )2 ] (X- =NO3- 1, benzoate 2, or 9-anthracenecarboxylato 3) have been prepared with the compartmental ligand N,N",N""-trimethyl-N,N""-bis(2-hydroxy-3-methoxy-5-methylbenzyl)diethylenetriamine (H2 L).	co(mu-l)(mu-x)y(no3 )2	66-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-30
28605076-1	2017	Three new closely related CoII YIII complexes of general formula [Co(mu-L)(mu-X)Y(NO3 )2 ] (X- =NO3- 1, benzoate 2, or 9-anthracenecarboxylato 3) have been prepared with the compartmental ligand N,N",N""-trimethyl-N,N""-bis(2-hydroxy-3-methoxy-5-methylbenzyl)diethylenetriamine (H2 L).	Benzoates	104-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-30
28605076-1	2017	Three new closely related CoII YIII complexes of general formula [Co(mu-L)(mu-X)Y(NO3 )2 ] (X- =NO3- 1, benzoate 2, or 9-anthracenecarboxylato 3) have been prepared with the compartmental ligand N,N",N""-trimethyl-N,N""-bis(2-hydroxy-3-methoxy-5-methylbenzyl)diethylenetriamine (H2 L).	9-anthracenecarboxylato 3	119-144	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-30
28605076-1	2017	Three new closely related CoII YIII complexes of general formula [Co(mu-L)(mu-X)Y(NO3 )2 ] (X- =NO3- 1, benzoate 2, or 9-anthracenecarboxylato 3) have been prepared with the compartmental ligand N,N",N""-trimethyl-N,N""-bis(2-hydroxy-3-methoxy-5-methylbenzyl)diethylenetriamine (H2 L).	n,n",n""-trimethyl-n,n""-bis(2-hydroxy-3-methoxy-5-methylbenzyl)diethylenetriamine	195-277	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-30
28605076-1	2017	Three new closely related CoII YIII complexes of general formula [Co(mu-L)(mu-X)Y(NO3 )2 ] (X- =NO3- 1, benzoate 2, or 9-anthracenecarboxylato 3) have been prepared with the compartmental ligand N,N",N""-trimethyl-N,N""-bis(2-hydroxy-3-methoxy-5-methylbenzyl)diethylenetriamine (H2 L).	Hydrogen	279-281	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-30
28605076-2	2017	In these complexes, CoII and YIII are triply bridged by two phenoxide groups belonging to the di-deprotonated ligand (L2- ) and one ancillary anion X- .	phenolate	60-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-24
28605076-4	2017	Direct current magnetic, high-frequency and -field EPR (HFEPR), frequency domain Fourier transform THz electron paramagnetic resonance (FD-FT THz-EPR) measurements, and ab initio theoretical calculations demonstrate that CoII ions in compounds 1-3 have large and positive D values ( 50 cm-1 ), which decrease with increasing the distortion of the pseudo-octahedral CoII coordination sphere.	thz	99-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	221-225
28605076-4	2017	Direct current magnetic, high-frequency and -field EPR (HFEPR), frequency domain Fourier transform THz electron paramagnetic resonance (FD-FT THz-EPR) measurements, and ab initio theoretical calculations demonstrate that CoII ions in compounds 1-3 have large and positive D values ( 50 cm-1 ), which decrease with increasing the distortion of the pseudo-octahedral CoII coordination sphere.	thz	142-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	221-225
28766674-0	2017	A mononuclear Co(ii) complex formed from pyridinedimethanol with manifold slow relaxation channels.	pyridinedimethanol	41-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-20
28766674-1	2017	A mononuclear hexacoordinate complex [Co(pydm)2](dnbz)2 formed from 2,6-pyridinedimethanol in the coordination sphere of Co(ii) and dinitrobenzoato anions exhibits magnetic anisotropy of an easy axis type and a field induced slow magnetic relaxation with manifold relaxation channels.	[co(pydm)2](dnbz)2	37-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-127
28766674-1	2017	A mononuclear hexacoordinate complex [Co(pydm)2](dnbz)2 formed from 2,6-pyridinedimethanol in the coordination sphere of Co(ii) and dinitrobenzoato anions exhibits magnetic anisotropy of an easy axis type and a field induced slow magnetic relaxation with manifold relaxation channels.	2,6-pyridinedimethanol	68-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-127
29034924-0	2017	Trapping of superoxido cobalt and peroxido dicobalt species formed reversibly from CoII and O2.	Cobalt	23-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-87
29034924-0	2017	Trapping of superoxido cobalt and peroxido dicobalt species formed reversibly from CoII and O2.	peroxido dicobalt	34-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-87
28621377-0	2017	Controlling the oxidation of bis-tridentate cobalt(ii) complexes having bis(2-pyridylalkyl)amines: ligand vs. metal oxidation.	bis-tridentate	29-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-53
28621377-0	2017	Controlling the oxidation of bis-tridentate cobalt(ii) complexes having bis(2-pyridylalkyl)amines: ligand vs. metal oxidation.	bis(2-pyridylalkyl)amines	72-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-53
28621377-0	2017	Controlling the oxidation of bis-tridentate cobalt(ii) complexes having bis(2-pyridylalkyl)amines: ligand vs. metal oxidation.	Metals	110-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-53
28621377-1	2017	Two bis-tridentate chelated cobalt(ii) complexes, which differ in the ligand structure by a methylene group, activate molecular oxygen (O2), and give different oxidation products.	Oxygen	128-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-37
28621377-1	2017	Two bis-tridentate chelated cobalt(ii) complexes, which differ in the ligand structure by a methylene group, activate molecular oxygen (O2), and give different oxidation products.	Oxygen	136-138	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-37
28621377-2	2017	The O2 reaction of [CoII(pepma)2]2+ (1) with unsymmetrical 2-(2-pyridyl)-N-(2-pyridylmethyl)ethanamine (pepma) results in ligand oxidation, to the corresponding Co(ii) imine complex [CoII(pepmi)2]2+ (2).	2-(2-pyridyl)-n-(2-pyridylmethyl)ethanamine	59-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	161-167
28621377-3	2017	Contrastingly, the Co(ii) complex [CoII(bpma)2]2+ (3) of similar symmetrical bis(2-pyridylmethyl)amine (bpma), undergoes metal oxidation, yielding a cobalt(iii) complex, [CoIII(bpma)2]2+ (4).	bis(2-pyridyl)methylamine	39-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-25
28621377-3	2017	Contrastingly, the Co(ii) complex [CoII(bpma)2]2+ (3) of similar symmetrical bis(2-pyridylmethyl)amine (bpma), undergoes metal oxidation, yielding a cobalt(iii) complex, [CoIII(bpma)2]2+ (4).	bis(2-pyridyl)methylamine	77-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-25
28621377-3	2017	Contrastingly, the Co(ii) complex [CoII(bpma)2]2+ (3) of similar symmetrical bis(2-pyridylmethyl)amine (bpma), undergoes metal oxidation, yielding a cobalt(iii) complex, [CoIII(bpma)2]2+ (4).	bis(2-pyridyl)methylamine	40-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-25
28621377-3	2017	Contrastingly, the Co(ii) complex [CoII(bpma)2]2+ (3) of similar symmetrical bis(2-pyridylmethyl)amine (bpma), undergoes metal oxidation, yielding a cobalt(iii) complex, [CoIII(bpma)2]2+ (4).	cobalt(iii)	149-160	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-25
28621377-3	2017	Contrastingly, the Co(ii) complex [CoII(bpma)2]2+ (3) of similar symmetrical bis(2-pyridylmethyl)amine (bpma), undergoes metal oxidation, yielding a cobalt(iii) complex, [CoIII(bpma)2]2+ (4).	coiii(bpma)2	171-183	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-25
28621377-5	2017	Furthermore, the solution dynamics of Co(ii) complexes are highlighted with the help of paramagnetic 1H-NMR spectroscopy.	Hydrogen	101-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-44
28758752-4	2017	In the above heteroleptic complexes, the Lewis acidic, coordinatively unsaturated CoII/FeII centers chelated by two hexafluoroacetylacetonate (hfac) ligands maintain bridging interactions with oxygen atoms of acetylacetonate (acac) groups that chelate the neighboring FeIII metal ion.	hexafluoroacetylacetonate	116-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-86
28758752-4	2017	In the above heteroleptic complexes, the Lewis acidic, coordinatively unsaturated CoII/FeII centers chelated by two hexafluoroacetylacetonate (hfac) ligands maintain bridging interactions with oxygen atoms of acetylacetonate (acac) groups that chelate the neighboring FeIII metal ion.	Oxygen	193-199	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-86
28758752-4	2017	In the above heteroleptic complexes, the Lewis acidic, coordinatively unsaturated CoII/FeII centers chelated by two hexafluoroacetylacetonate (hfac) ligands maintain bridging interactions with oxygen atoms of acetylacetonate (acac) groups that chelate the neighboring FeIII metal ion.	acetyl acetonate	126-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-86
28758752-4	2017	In the above heteroleptic complexes, the Lewis acidic, coordinatively unsaturated CoII/FeII centers chelated by two hexafluoroacetylacetonate (hfac) ligands maintain bridging interactions with oxygen atoms of acetylacetonate (acac) groups that chelate the neighboring FeIII metal ion.	acetyl acetonate	226-230	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-86
28758752-4	2017	In the above heteroleptic complexes, the Lewis acidic, coordinatively unsaturated CoII/FeII centers chelated by two hexafluoroacetylacetonate (hfac) ligands maintain bridging interactions with oxygen atoms of acetylacetonate (acac) groups that chelate the neighboring FeIII metal ion.	Metals	274-279	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-86
28766939-5	2017	Here, we present magnetic resonance imaging (MRI) as an accessible and powerful technique to monitor bioreduction by treating the cobalt complex as an MRI contrast agent and monitoring the change in water signal induced by reduction from diamagnetic Co(III) to paramagnetic Co(II).	Water	199-204	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	274-280
28499169-0	2017	Two novel dinuclear ellipsoid Ni(II) and Co(II) complexes bridged by 4,5-bis(pyrazol-1-yl)phthalic acid: Synthesis, structural characterization and biological evaluation.	4,5-bis(pyrazol-1-yl)phthalic acid	69-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-47
28499169-2	2017	The structures for the complexes were determined by X-ray crystallography providing the dinuclear ellipsoid Ni(II) and Co(II) complexes bridged by 4,5-bis(pyrazol-1-yl)phthalic acid ligands with same coordination modes.	4,5-bis(pyrazol-1-yl)phthalic acid	147-181	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-125
28787164-0	2017	Co(II)-Catalyzed Regioselective Cross-Dehydrogenative Coupling of Aryl C-H Bonds with Carboxylic Acids.	Carboxylic Acids	86-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
28759223-4	2017	Despite generating less photocurrent, CoII/III(pz-py-pz)2 devices achieved maximum TTA-UC efficiency at excitation intensities well below solar irradiance (0.8 mW cm-2), which is on par with the lowest value yet reported for any TTA-UC system.	(pz-py-pz)2	46-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-42
28759223-4	2017	Despite generating less photocurrent, CoII/III(pz-py-pz)2 devices achieved maximum TTA-UC efficiency at excitation intensities well below solar irradiance (0.8 mW cm-2), which is on par with the lowest value yet reported for any TTA-UC system.	tta-uc	83-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-42
28759223-4	2017	Despite generating less photocurrent, CoII/III(pz-py-pz)2 devices achieved maximum TTA-UC efficiency at excitation intensities well below solar irradiance (0.8 mW cm-2), which is on par with the lowest value yet reported for any TTA-UC system.	tta-uc	229-235	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-42
28720504-0	2017	Synthesis of novel hybrids of pyrazole and coumarin as dual inhibitors of COX-2 and 5-LOX.	pyrazole	30-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
28720504-0	2017	Synthesis of novel hybrids of pyrazole and coumarin as dual inhibitors of COX-2 and 5-LOX.	coumarin	43-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
28720504-1	2017	In our previous study, we designed a series of pyrazole derivatives as novel COX-2 inhibitors.	pyrazole	47-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-82
28652251-3	2017	Reduced expression of DUSP2 led to overproduction of COX-2-derived prostaglandin E2, which promoted cancer stemness via the EP2/EP4 signaling pathways.	Dinoprostone	67-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-58
28807001-10	2017	Combination of anti-CTLA-4 with selumetinib negated this up-regulation of Cox-2 and Arg1, reduced the frequency of CD11+ Ly6G+ myeloid cells, and led to the accumulation of differentiating monocytes at the Ly6C+ MHC+ intermediate state in the tumor.	AZD 6244	32-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
28532672-1	2017	In this study, we found that catechins found in green tea (EGCG, EGC, and EC) differentially interfere with the IL-1beta signaling pathway which regulates the expression of pro-inflammatory mediators (IL-6 and IL-8) and Cox-2 in primary human rheumatoid arthritis synovial fibroblasts (RASFs).	Catechin	29-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	220-225
28532672-1	2017	In this study, we found that catechins found in green tea (EGCG, EGC, and EC) differentially interfere with the IL-1beta signaling pathway which regulates the expression of pro-inflammatory mediators (IL-6 and IL-8) and Cox-2 in primary human rheumatoid arthritis synovial fibroblasts (RASFs).	epigallocatechin gallate	59-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	220-225
28447182-0	2017	Co(II) Complexes of4-((3-ethoxy-2-hydroxybenzylidene)amino)-N-(thiazol-2-yl)benzenesulphonamide and 4-((pyridin-2-ylmethylene)amino)-N-(thiazol-2-tl)benzenesulfonamide: Synthesis, Fluorescence Properties and Anticancer Activity.	-((3-ethoxy-2-hydroxybenzylidene)amino)-n-(thiazol-2-yl)benzenesulphonamide	20-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
28532672-1	2017	In this study, we found that catechins found in green tea (EGCG, EGC, and EC) differentially interfere with the IL-1beta signaling pathway which regulates the expression of pro-inflammatory mediators (IL-6 and IL-8) and Cox-2 in primary human rheumatoid arthritis synovial fibroblasts (RASFs).	gallocatechol	59-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	220-225
28447182-0	2017	Co(II) Complexes of4-((3-ethoxy-2-hydroxybenzylidene)amino)-N-(thiazol-2-yl)benzenesulphonamide and 4-((pyridin-2-ylmethylene)amino)-N-(thiazol-2-tl)benzenesulfonamide: Synthesis, Fluorescence Properties and Anticancer Activity.	4-((pyridin-2-ylmethylene)amino)-n-(thiazol-2-tl)benzenesulfonamide	100-167	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
28447182-1	2017	Two new Co(II) complexes of 4-((3-ethoxy-2-hydroxybenzylidene)amino)-N-(thiazol-2-yl)benzenesulphonamide and 4-((pyridin-2-ylmethylene)amino)-N-(thiazol-2-yl)benzene sulfonamide were synthesised.	4-((3-ethoxy-2-hydroxybenzylidene)amino)-n-(thiazol-2-yl)benzenesulphonamide	28-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	8-14
28532672-1	2017	In this study, we found that catechins found in green tea (EGCG, EGC, and EC) differentially interfere with the IL-1beta signaling pathway which regulates the expression of pro-inflammatory mediators (IL-6 and IL-8) and Cox-2 in primary human rheumatoid arthritis synovial fibroblasts (RASFs).	ec	74-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	220-225
28532672-2	2017	EGCG and EGC inhibited IL-6, IL-8, and MMP-2 production and selectively inhibited Cox-2 expression.	epigallocatechin gallate	0-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
28532672-2	2017	EGCG and EGC inhibited IL-6, IL-8, and MMP-2 production and selectively inhibited Cox-2 expression.	gallocatechol	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
28685572-1	2017	A Co(II)-catalyzed isocyanide insertion reaction with sulfonyl azides in alcohols to form sulfonyl isoureas via nitrene intermediate has been developed.	Cyanides	19-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	2-8
28800793-0	2017	WITHDRAWN: Upregulation of HINT2 Inhibits Non-Small Cell Lung Cancer Cell Invasion Via COX-2/PGE2-Mediated Activation of ss-catenin Signaling.	Dinoprostone	93-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-92
28714576-2	2017	Herein, metalloporphyrinic MOFs, PCN-224-FeCo, with adjustable molar ratio of FeII /CoII alternatively residing inside the porphyrin center, were employed as precursors to afford FeCo-N-doped porous carbon (denoted as FeCo-NPC) by pyrolysis.	Pregnenolone Carbonitrile	33-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-88
28714576-2	2017	Herein, metalloporphyrinic MOFs, PCN-224-FeCo, with adjustable molar ratio of FeII /CoII alternatively residing inside the porphyrin center, were employed as precursors to afford FeCo-N-doped porous carbon (denoted as FeCo-NPC) by pyrolysis.	feco-n	179-185	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-88
28368394-7	2017	In addition, the inhibition of COX-2-mediated matriptase activation by Celebrex and sulindac sulfide suppressed the androgen-independent and COX2-overexpressing PCa PC-3 cell invasion, tumor growth and lung metastasis in an orthotopic xenograft model.	Celecoxib	71-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	141-145
28368394-7	2017	In addition, the inhibition of COX-2-mediated matriptase activation by Celebrex and sulindac sulfide suppressed the androgen-independent and COX2-overexpressing PCa PC-3 cell invasion, tumor growth and lung metastasis in an orthotopic xenograft model.	sulindac sulfide	84-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	141-145
28685572-1	2017	A Co(II)-catalyzed isocyanide insertion reaction with sulfonyl azides in alcohols to form sulfonyl isoureas via nitrene intermediate has been developed.	sulfonyl azides	54-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	2-8
28685572-1	2017	A Co(II)-catalyzed isocyanide insertion reaction with sulfonyl azides in alcohols to form sulfonyl isoureas via nitrene intermediate has been developed.	Alcohols	73-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	2-8
28685572-1	2017	A Co(II)-catalyzed isocyanide insertion reaction with sulfonyl azides in alcohols to form sulfonyl isoureas via nitrene intermediate has been developed.	sulfonyl isoureas	90-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	2-8
28685572-1	2017	A Co(II)-catalyzed isocyanide insertion reaction with sulfonyl azides in alcohols to form sulfonyl isoureas via nitrene intermediate has been developed.	phenylnitrene	112-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	2-8
28776513-4	2017	The CoII ion adopts an S = 3/2 spin state, as measured by the Evans NMR method, and UV-visible spectroscopic studies indicate that the title hydrated salt is stable in solution.	Salts	150-154	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-8
28939019-11	2017	MEMH inhibited NFkappaB signaling pathway and COX-2 protein expression in chondrocytes.	memh	0-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
28762981-1	2017	Four novel coordination polymers (CPs) assembled with [2,2"-bifuran]-5,5"-dicarboxylic acid (H2L) and metal ions ZnII, CdII or CoII have been successfully synthesized.	Polymers	24-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	127-131
28762981-1	2017	Four novel coordination polymers (CPs) assembled with [2,2"-bifuran]-5,5"-dicarboxylic acid (H2L) and metal ions ZnII, CdII or CoII have been successfully synthesized.	cps	34-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	127-131
28605057-0	2017	Synthesis and Biological Evaluation of New Diarylpyrazole and Triarylimidazoline Derivatives as Selective COX-2 Inhibitors.	diarylpyrazole	43-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-111
28605057-0	2017	Synthesis and Biological Evaluation of New Diarylpyrazole and Triarylimidazoline Derivatives as Selective COX-2 Inhibitors.	triarylimidazoline	62-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-111
28605057-2	2017	The synthesized compounds showed good selectivity for COX-2; compounds 8a, 8d, 8f, 11a, and 11c exhibited the highest COX-2 selectivity indexes (SI = 4.77-5.43) compared to the reference drug celecoxib (SI = 7.8).	Celecoxib	192-201	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-59
28605057-2	2017	The synthesized compounds showed good selectivity for COX-2; compounds 8a, 8d, 8f, 11a, and 11c exhibited the highest COX-2 selectivity indexes (SI = 4.77-5.43) compared to the reference drug celecoxib (SI = 7.8).	Celecoxib	192-201	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-123
28450158-2	2017	The purpose of this work was to determine the ability of the COX-2 inhibitor Celecoxib to modulate the EGFR-AR signaling pathway in androgen-dependent PCa cells and to provide a rationale for its beneficial use in chemopreventive strategies.	Celecoxib	77-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-66
28479391-0	2017	Differential cytotoxic activity of Quercetin on colonic cancer cells depends on ROS generation through COX-2 expression.	Quercetin	35-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-108
28479391-0	2017	Differential cytotoxic activity of Quercetin on colonic cancer cells depends on ROS generation through COX-2 expression.	Reactive Oxygen Species	80-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-108
28479391-5	2017	Though, nuclear translocation of NFkB was increased in 40 muM Quercetin treated HT29 and HCT15 cells, over expression of COX-2 was observed in 40 muM Quercetin treated HT29 cells, whereas, Quercetin treated HCT15 cells did not expressed COX-2.	Quercetin	62-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-126
28586004-1	2017	The conversion of arachidonic acid into prostaglandins by cyclooxygenase (COX)-2 contributes to the biological properties of malignant tumours.	Arachidonic Acid	18-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-80
28586004-1	2017	The conversion of arachidonic acid into prostaglandins by cyclooxygenase (COX)-2 contributes to the biological properties of malignant tumours.	Prostaglandins	40-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-80
28551529-4	2017	To address this gap, we report here an examination of the reactions of H2S, HS-, and S8 with MgII, CuII, CoII, ZnII, CrII, SnIV, and MnII/III protoporphyrins.	Hydrogen Sulfide	71-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-109
28552807-7	2017	Also, LPS-induced iNOS and COX-2 expression were attenuated by glycyrrhizin.	Glycyrrhizic Acid	63-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-32
28911173-0	2017	Lithium Chloride Increases COX-2 Expression and PGE2 Production in a Human Granulosa-Lutein SVOG Cell Line Via a GSK-3beta/beta-Catenin Signaling Pathway.	Lithium Chloride	0-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-32
28479391-5	2017	Though, nuclear translocation of NFkB was increased in 40 muM Quercetin treated HT29 and HCT15 cells, over expression of COX-2 was observed in 40 muM Quercetin treated HT29 cells, whereas, Quercetin treated HCT15 cells did not expressed COX-2.	Quercetin	62-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	237-242
28479391-5	2017	Though, nuclear translocation of NFkB was increased in 40 muM Quercetin treated HT29 and HCT15 cells, over expression of COX-2 was observed in 40 muM Quercetin treated HT29 cells, whereas, Quercetin treated HCT15 cells did not expressed COX-2.	Quercetin	150-159	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-126
28479391-5	2017	Though, nuclear translocation of NFkB was increased in 40 muM Quercetin treated HT29 and HCT15 cells, over expression of COX-2 was observed in 40 muM Quercetin treated HT29 cells, whereas, Quercetin treated HCT15 cells did not expressed COX-2.	Quercetin	150-159	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	237-242
28479391-5	2017	Though, nuclear translocation of NFkB was increased in 40 muM Quercetin treated HT29 and HCT15 cells, over expression of COX-2 was observed in 40 muM Quercetin treated HT29 cells, whereas, Quercetin treated HCT15 cells did not expressed COX-2.	Quercetin	150-159	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-126
28479391-5	2017	Though, nuclear translocation of NFkB was increased in 40 muM Quercetin treated HT29 and HCT15 cells, over expression of COX-2 was observed in 40 muM Quercetin treated HT29 cells, whereas, Quercetin treated HCT15 cells did not expressed COX-2.	Quercetin	150-159	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	237-242
28479391-6	2017	Increased generation of reactive oxygen species (ROS) was observed only in Quercetin treated HT29 cells, which is due to over expression of COX-2, as COX-2 silencing inhibited Quercetin induced apoptosis and ROS generation.	Reactive Oxygen Species	24-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-145
28479391-6	2017	Increased generation of reactive oxygen species (ROS) was observed only in Quercetin treated HT29 cells, which is due to over expression of COX-2, as COX-2 silencing inhibited Quercetin induced apoptosis and ROS generation.	Reactive Oxygen Species	24-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	150-155
28479391-6	2017	Increased generation of reactive oxygen species (ROS) was observed only in Quercetin treated HT29 cells, which is due to over expression of COX-2, as COX-2 silencing inhibited Quercetin induced apoptosis and ROS generation.	Reactive Oxygen Species	49-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-145
28479391-6	2017	Increased generation of reactive oxygen species (ROS) was observed only in Quercetin treated HT29 cells, which is due to over expression of COX-2, as COX-2 silencing inhibited Quercetin induced apoptosis and ROS generation.	Reactive Oxygen Species	49-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	150-155
28479391-6	2017	Increased generation of reactive oxygen species (ROS) was observed only in Quercetin treated HT29 cells, which is due to over expression of COX-2, as COX-2 silencing inhibited Quercetin induced apoptosis and ROS generation.	Quercetin	75-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-145
28479391-6	2017	Increased generation of reactive oxygen species (ROS) was observed only in Quercetin treated HT29 cells, which is due to over expression of COX-2, as COX-2 silencing inhibited Quercetin induced apoptosis and ROS generation.	Quercetin	75-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	150-155
28479391-6	2017	Increased generation of reactive oxygen species (ROS) was observed only in Quercetin treated HT29 cells, which is due to over expression of COX-2, as COX-2 silencing inhibited Quercetin induced apoptosis and ROS generation.	Quercetin	176-185	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-145
28479391-6	2017	Increased generation of reactive oxygen species (ROS) was observed only in Quercetin treated HT29 cells, which is due to over expression of COX-2, as COX-2 silencing inhibited Quercetin induced apoptosis and ROS generation.	Quercetin	176-185	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	150-155
28479391-6	2017	Increased generation of reactive oxygen species (ROS) was observed only in Quercetin treated HT29 cells, which is due to over expression of COX-2, as COX-2 silencing inhibited Quercetin induced apoptosis and ROS generation.	Reactive Oxygen Species	208-211	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-145
28479391-6	2017	Increased generation of reactive oxygen species (ROS) was observed only in Quercetin treated HT29 cells, which is due to over expression of COX-2, as COX-2 silencing inhibited Quercetin induced apoptosis and ROS generation.	Reactive Oxygen Species	208-211	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	150-155
28479391-7	2017	Insilico analysis provided evidence that Quercetin could partially inhibit COX-2 enzyme by binding to subunit A which has peroxidase activity and serves as source of ROS.	Quercetin	41-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
28479391-7	2017	Insilico analysis provided evidence that Quercetin could partially inhibit COX-2 enzyme by binding to subunit A which has peroxidase activity and serves as source of ROS.	Reactive Oxygen Species	166-169	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
28479391-9	2017	To conclude, differential sensitivity of two cancer cells, HT29 and HCT15, to Quercetin depends on COX-2 dependent ROS generation that induces apoptosis and inhibits cell survival.	Quercetin	78-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-104
28479391-9	2017	To conclude, differential sensitivity of two cancer cells, HT29 and HCT15, to Quercetin depends on COX-2 dependent ROS generation that induces apoptosis and inhibits cell survival.	Reactive Oxygen Species	115-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-104
28656311-3	2017	Oleocanthal (OC) is a naturally occurring minor phenolic compound isolated from EVOO, which has shown a potent anti-inflammatory activity, by means of its ability to inhibit the cyclooxygenase (COX) enzymes COX-1 and COX-2.	oleocanthal	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	217-222
28656311-3	2017	Oleocanthal (OC) is a naturally occurring minor phenolic compound isolated from EVOO, which has shown a potent anti-inflammatory activity, by means of its ability to inhibit the cyclooxygenase (COX) enzymes COX-1 and COX-2.	oleocanthal	13-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	217-222
28656311-3	2017	Oleocanthal (OC) is a naturally occurring minor phenolic compound isolated from EVOO, which has shown a potent anti-inflammatory activity, by means of its ability to inhibit the cyclooxygenase (COX) enzymes COX-1 and COX-2.	evoo	80-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	217-222
28781793-11	2017	On immunohistochemical examination, cyclooxygenase (COX)-1 and COX-2 were strongly positive, indicating that the tumor activated the arachidonic acid metabolic pathway and produced prostaglandin.	Arachidonic Acid	133-149	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-68
28781793-11	2017	On immunohistochemical examination, cyclooxygenase (COX)-1 and COX-2 were strongly positive, indicating that the tumor activated the arachidonic acid metabolic pathway and produced prostaglandin.	Prostaglandins	181-194	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-68
28737690-0	2017	Synthesis, Physico-chemical Characterization, Crystal Structure and Influence on Microbial and Tumor Cells of Some Co(II) Complexes with 5,7-Dimethyl-1,2,4-triazolo[1,5-a]pyrimidine.	5,7-dimethyl-(1,2,4)triazolo(1,5-a)pyrimidine	137-181	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-120
28738843-7	2017	RESULTS: In the current study, ASX exhibited significant protective effect against the Co(II)-induced cytotoxicity in MG-63 cell line.	astaxanthine	31-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-93
31457696-4	2017	The photosensitizing efficiencies of these Ru(II)-photosensitizer-immobilized nanoparticles for the O2 evolution reaction catalyzed by the Co(II)-containing Prussian blue analogue [CoII(H2O)2]1.31[{CoIII(CN)6}0.63{PtII(CN)4}0.37] decreased as the number of Ru(II)-photosensitizing layers increased.	ru(ii)	43-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-144
31457696-4	2017	The photosensitizing efficiencies of these Ru(II)-photosensitizer-immobilized nanoparticles for the O2 evolution reaction catalyzed by the Co(II)-containing Prussian blue analogue [CoII(H2O)2]1.31[{CoIII(CN)6}0.63{PtII(CN)4}0.37] decreased as the number of Ru(II)-photosensitizing layers increased.	Oxygen	100-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-144
31457696-4	2017	The photosensitizing efficiencies of these Ru(II)-photosensitizer-immobilized nanoparticles for the O2 evolution reaction catalyzed by the Co(II)-containing Prussian blue analogue [CoII(H2O)2]1.31[{CoIII(CN)6}0.63{PtII(CN)4}0.37] decreased as the number of Ru(II)-photosensitizing layers increased.	ferric ferrocyanide	157-170	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-144
31457696-4	2017	The photosensitizing efficiencies of these Ru(II)-photosensitizer-immobilized nanoparticles for the O2 evolution reaction catalyzed by the Co(II)-containing Prussian blue analogue [CoII(H2O)2]1.31[{CoIII(CN)6}0.63{PtII(CN)4}0.37] decreased as the number of Ru(II)-photosensitizing layers increased.	coii(h2o)2	181-191	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-144
31457696-4	2017	The photosensitizing efficiencies of these Ru(II)-photosensitizer-immobilized nanoparticles for the O2 evolution reaction catalyzed by the Co(II)-containing Prussian blue analogue [CoII(H2O)2]1.31[{CoIII(CN)6}0.63{PtII(CN)4}0.37] decreased as the number of Ru(II)-photosensitizing layers increased.	cobalt adenosine diphosphate complex	198-203	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-144
31457696-4	2017	The photosensitizing efficiencies of these Ru(II)-photosensitizer-immobilized nanoparticles for the O2 evolution reaction catalyzed by the Co(II)-containing Prussian blue analogue [CoII(H2O)2]1.31[{CoIII(CN)6}0.63{PtII(CN)4}0.37] decreased as the number of Ru(II)-photosensitizing layers increased.	Platinum(2+)	214-218	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-144
31457696-4	2017	The photosensitizing efficiencies of these Ru(II)-photosensitizer-immobilized nanoparticles for the O2 evolution reaction catalyzed by the Co(II)-containing Prussian blue analogue [CoII(H2O)2]1.31[{CoIII(CN)6}0.63{PtII(CN)4}0.37] decreased as the number of Ru(II)-photosensitizing layers increased.	ru(ii)	257-263	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-144
28671820-0	2017	Slow Magnetic Relaxation in One-Dimensional Azido-Bridged CoII Complexes.	3',5-diazido-2',3'-dideoxyuridine	44-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-62
28512770-0	2017	Role of Halide Ions in the Nature of the Magnetic Anisotropy in Tetrahedral CoII Complexes.	halide	8-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-80
28512770-1	2017	A series of mononuclear tetrahedral CoII complexes with a general molecular formula [CoL2 X2 ] [L=thiourea and X=Cl (1), Br (2) and I (3)] were synthesized and their structures were characterized by single-crystal X-ray diffraction.	Thiourea	98-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-40
28671820-5	2017	Similarly, the chain structure of 3 is constructed from a similar tetramer unit {[CoN5][CoN4O2]2[CoN5]} (denoted as Co4B), where half of the CoII centers are in the [CoN5] trigonal bipyramid because of the larger steric effect of the DIPF ligand, while, for compound 2 of the medium-sized amide, it has the transition structure between those of 1 and 3.	co4b	116-120	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	141-145
28671845-0	2017	Understanding the Lewis Acidity of Co(II) Sites on a Silica Surface.	Silicon Dioxide	53-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-41
29137258-4	2017	Cox-2 stimulates GSC self-renewal and proliferation through prostaglandin E2 (PGE2), which in turn activates the Wnt signaling pathway.	Dinoprostone	60-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
29137258-4	2017	Cox-2 stimulates GSC self-renewal and proliferation through prostaglandin E2 (PGE2), which in turn activates the Wnt signaling pathway.	Dinoprostone	78-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
29137258-7	2017	Our findings uncover an aberrant positive feedback interaction between the Cox-2/PGE2 and Wnt pathways that mediates the stem-like state in glioblastoma.	Dinoprostone	81-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
28671845-3	2017	A recent report from our group showed that silica-supported Co(II) sites, prepared via surface organometallic chemistry, are active in both alkene hydrogenation and alkane dehydrogenation, possibly linked to the Lewis acidity of the Co(II) sites.	Silicon Dioxide	43-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-66
28671845-3	2017	A recent report from our group showed that silica-supported Co(II) sites, prepared via surface organometallic chemistry, are active in both alkene hydrogenation and alkane dehydrogenation, possibly linked to the Lewis acidity of the Co(II) sites.	Silicon Dioxide	43-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	233-239
28671845-3	2017	A recent report from our group showed that silica-supported Co(II) sites, prepared via surface organometallic chemistry, are active in both alkene hydrogenation and alkane dehydrogenation, possibly linked to the Lewis acidity of the Co(II) sites.	Alkenes	140-146	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-66
28671845-3	2017	A recent report from our group showed that silica-supported Co(II) sites, prepared via surface organometallic chemistry, are active in both alkene hydrogenation and alkane dehydrogenation, possibly linked to the Lewis acidity of the Co(II) sites.	Alkenes	140-146	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	233-239
28671845-3	2017	A recent report from our group showed that silica-supported Co(II) sites, prepared via surface organometallic chemistry, are active in both alkene hydrogenation and alkane dehydrogenation, possibly linked to the Lewis acidity of the Co(II) sites.	Alkanes	165-171	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-66
28671845-3	2017	A recent report from our group showed that silica-supported Co(II) sites, prepared via surface organometallic chemistry, are active in both alkene hydrogenation and alkane dehydrogenation, possibly linked to the Lewis acidity of the Co(II) sites.	Alkanes	165-171	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	233-239
28609105-1	2017	We investigate ligand-exchange reactions of a biomimetic Co(II)-based heterocubane complex in aqueous solution by means of various approaches for consideration of solvent effects.	heterocubane	70-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-62
28488285-3	2017	Experimental results revealed that the parent [CoII CoII ] complex undergoes two successive metal-based 1 e- reductions to generate the catalytically active species [CoI CoI ], and DFT calculations suggested that addition of a proton to one CoI triggers a cooperative 1 e- transfer by each of these CoI centers.	Metals	92-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-51
28488285-3	2017	Experimental results revealed that the parent [CoII CoII ] complex undergoes two successive metal-based 1 e- reductions to generate the catalytically active species [CoI CoI ], and DFT calculations suggested that addition of a proton to one CoI triggers a cooperative 1 e- transfer by each of these CoI centers.	Metals	92-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-56
28488285-5	2017	This [CoII (CoII -H- )] species then accepts another H+ to release H2 .	Hydrogen	67-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	6-10
28488285-5	2017	This [CoII (CoII -H- )] species then accepts another H+ to release H2 .	Hydrogen	67-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-16
28502905-11	2017	The resulted potent COX-2 inhibitor of the isolated constituents compound 5, designated as coumaroyl lupendioic acid (CLA), was investigated in carrageenan induced inflammation and its effect was also compared with betulinic acid (BA) at the doses of 10 and 20mgkg-1, p.o.	coumaroyl lupendioic acid	91-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-25
28502905-11	2017	The resulted potent COX-2 inhibitor of the isolated constituents compound 5, designated as coumaroyl lupendioic acid (CLA), was investigated in carrageenan induced inflammation and its effect was also compared with betulinic acid (BA) at the doses of 10 and 20mgkg-1, p.o.	Clarithromycin	118-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-25
28502905-16	2017	Among the all isolated compounds 3beta-O-trans-coumaryl-lup-6, 9(11), 20(29)-triene-27, 28-olioic acid designated as coumaroyl lupendioic acid (CLA) showed higher COX-2 selectivity which is comparable to reference drug (celecoxib).	3beta-o-trans-coumaryl-lup-6	33-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	163-168
28502905-16	2017	Among the all isolated compounds 3beta-O-trans-coumaryl-lup-6, 9(11), 20(29)-triene-27, 28-olioic acid designated as coumaroyl lupendioic acid (CLA) showed higher COX-2 selectivity which is comparable to reference drug (celecoxib).	triene-27, 28-olioic acid	77-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	163-168
28502905-16	2017	Among the all isolated compounds 3beta-O-trans-coumaryl-lup-6, 9(11), 20(29)-triene-27, 28-olioic acid designated as coumaroyl lupendioic acid (CLA) showed higher COX-2 selectivity which is comparable to reference drug (celecoxib).	coumaroyl lupendioic acid	117-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	163-168
28502905-20	2017	Furthermore, immunohistochemical studies revealed that CLA significantly down regulated NF-kB, COX-2 and TNF-alpha protein expression.	Clarithromycin	55-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-100
28696369-4	2017	It was discovered that DHAP downregulated the expression of oncogenic gene products like Bcl-xl, Bcl-2, Mcl-1, Survivin, Cyclin D1, IAP-1, Cyclin E, COX-2, and MMP-9, and upregulated the expression of Bax and p21 proteins, consistent with the induction of G2/M phase cell cycle arrest and apoptosis in U266 cells.	Dihydroxyacetone Phosphate	23-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	149-154
28617591-2	2017	Co(II) spins in a chain are ferromagnetically coupled through carboxylate and phenoxide bridges.	carboxylate	62-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
28676124-10	2017	Another finding was the concomitant use of COX-2 inhibitors (Etoricoxib or Celecoxib) and PPIs.	Etoricoxib	61-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
28676124-10	2017	Another finding was the concomitant use of COX-2 inhibitors (Etoricoxib or Celecoxib) and PPIs.	Celecoxib	75-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
28617591-2	2017	Co(II) spins in a chain are ferromagnetically coupled through carboxylate and phenoxide bridges.	phenolate	78-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
28605198-1	2017	An anionic CoII complex, [Co(TTT) (NCS)3]- (TTT = 4,4",4""-tri-tert-butyl-2,2":6",2""-terpyridine and NCS = isothiocyanate), was synthesized for use in dye-sensitized solar cells (DSSCs).	4,4',4''-tri-tert-butyl-2,2'-6',2''-terpyridine	50-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-15
28605198-1	2017	An anionic CoII complex, [Co(TTT) (NCS)3]- (TTT = 4,4",4""-tri-tert-butyl-2,2":6",2""-terpyridine and NCS = isothiocyanate), was synthesized for use in dye-sensitized solar cells (DSSCs).	isothiocyanic acid	108-122	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-15
28668885-7	2017	TX-1123 bound to the COX2 molecule, and the oxygen atom of the 4-cyclopentene-1,3-dione region of TX-1123 interacted with Cys26 and Gln447 of COX2.	Oxygen	44-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	142-146
28605198-2	2017	The CoII complex was found to ion-pair with the hexacationic sensitizer [Ru(tmam)2(dcb)]6+ (tmam = 4,4"-bis(trimethylaminomethyl)-2,2"-bipyridine and dcb = 4,4"-(CO2H)2-2,2"-bipyridine) anchored to TiO2 thin films immersed in acetonitrile solution.	ru(tmam)2(dcb)]6+	73-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-8
28605198-2	2017	The CoII complex was found to ion-pair with the hexacationic sensitizer [Ru(tmam)2(dcb)]6+ (tmam = 4,4"-bis(trimethylaminomethyl)-2,2"-bipyridine and dcb = 4,4"-(CO2H)2-2,2"-bipyridine) anchored to TiO2 thin films immersed in acetonitrile solution.	tmam	76-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-8
28605198-2	2017	The CoII complex was found to ion-pair with the hexacationic sensitizer [Ru(tmam)2(dcb)]6+ (tmam = 4,4"-bis(trimethylaminomethyl)-2,2"-bipyridine and dcb = 4,4"-(CO2H)2-2,2"-bipyridine) anchored to TiO2 thin films immersed in acetonitrile solution.	4,4"-bis(trimethylaminomethyl)-2,2"-bipyridine	99-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-8
28605198-2	2017	The CoII complex was found to ion-pair with the hexacationic sensitizer [Ru(tmam)2(dcb)]6+ (tmam = 4,4"-bis(trimethylaminomethyl)-2,2"-bipyridine and dcb = 4,4"-(CO2H)2-2,2"-bipyridine) anchored to TiO2 thin films immersed in acetonitrile solution.	dcb	83-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-8
28605198-2	2017	The CoII complex was found to ion-pair with the hexacationic sensitizer [Ru(tmam)2(dcb)]6+ (tmam = 4,4"-bis(trimethylaminomethyl)-2,2"-bipyridine and dcb = 4,4"-(CO2H)2-2,2"-bipyridine) anchored to TiO2 thin films immersed in acetonitrile solution.	4,4"-(co2h)2-2,2"-bipyridine	156-184	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-8
28605198-2	2017	The CoII complex was found to ion-pair with the hexacationic sensitizer [Ru(tmam)2(dcb)]6+ (tmam = 4,4"-bis(trimethylaminomethyl)-2,2"-bipyridine and dcb = 4,4"-(CO2H)2-2,2"-bipyridine) anchored to TiO2 thin films immersed in acetonitrile solution.	titanium dioxide	198-202	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-8
28605198-2	2017	The CoII complex was found to ion-pair with the hexacationic sensitizer [Ru(tmam)2(dcb)]6+ (tmam = 4,4"-bis(trimethylaminomethyl)-2,2"-bipyridine and dcb = 4,4"-(CO2H)2-2,2"-bipyridine) anchored to TiO2 thin films immersed in acetonitrile solution.	acetonitrile	226-238	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-8
28613850-0	2017	A Highly Selective and Robust Co(II)-Based Homogeneous Catalyst for Reduction of CO2 to CO in CH3CN/H2O Solution Driven by Visible Light.	N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)-4-((4-fluorobenzyl)oxy)pyridine-2,6-dicarboxamide	81-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-35
28613850-0	2017	A Highly Selective and Robust Co(II)-Based Homogeneous Catalyst for Reduction of CO2 to CO in CH3CN/H2O Solution Driven by Visible Light.	Carbon Monoxide	81-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-35
28613850-0	2017	A Highly Selective and Robust Co(II)-Based Homogeneous Catalyst for Reduction of CO2 to CO in CH3CN/H2O Solution Driven by Visible Light.	acetonitrile	94-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-35
28613850-0	2017	A Highly Selective and Robust Co(II)-Based Homogeneous Catalyst for Reduction of CO2 to CO in CH3CN/H2O Solution Driven by Visible Light.	Water	100-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-35
28613850-3	2017	Herein, we report a Co(II)-based homogeneous catalyst, [Co(NTB)CH3CN](ClO4)2 (1, NTB = tris(benzimidazolyl-2-methyl)amine), which shows high selectivity and stability for the catalytic reduction of CO2 to CO in a water-containing system driven by visible light, with turnover number (TON) and turnover frequency (TOF) values of 1179 and 0.032 s-1, respectively, and selectivity to CO of 97%.	co(ntb)ch3cn	56-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-25
28613850-3	2017	Herein, we report a Co(II)-based homogeneous catalyst, [Co(NTB)CH3CN](ClO4)2 (1, NTB = tris(benzimidazolyl-2-methyl)amine), which shows high selectivity and stability for the catalytic reduction of CO2 to CO in a water-containing system driven by visible light, with turnover number (TON) and turnover frequency (TOF) values of 1179 and 0.032 s-1, respectively, and selectivity to CO of 97%.	perchlorate	70-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-25
28613850-3	2017	Herein, we report a Co(II)-based homogeneous catalyst, [Co(NTB)CH3CN](ClO4)2 (1, NTB = tris(benzimidazolyl-2-methyl)amine), which shows high selectivity and stability for the catalytic reduction of CO2 to CO in a water-containing system driven by visible light, with turnover number (TON) and turnover frequency (TOF) values of 1179 and 0.032 s-1, respectively, and selectivity to CO of 97%.	naltrindole benzofuran	59-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-25
28613850-3	2017	Herein, we report a Co(II)-based homogeneous catalyst, [Co(NTB)CH3CN](ClO4)2 (1, NTB = tris(benzimidazolyl-2-methyl)amine), which shows high selectivity and stability for the catalytic reduction of CO2 to CO in a water-containing system driven by visible light, with turnover number (TON) and turnover frequency (TOF) values of 1179 and 0.032 s-1, respectively, and selectivity to CO of 97%.	Tromethamine	87-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-25
28613850-3	2017	Herein, we report a Co(II)-based homogeneous catalyst, [Co(NTB)CH3CN](ClO4)2 (1, NTB = tris(benzimidazolyl-2-methyl)amine), which shows high selectivity and stability for the catalytic reduction of CO2 to CO in a water-containing system driven by visible light, with turnover number (TON) and turnover frequency (TOF) values of 1179 and 0.032 s-1, respectively, and selectivity to CO of 97%.	benzimidazolyl-2-methyl)amine	92-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-25
28613850-3	2017	Herein, we report a Co(II)-based homogeneous catalyst, [Co(NTB)CH3CN](ClO4)2 (1, NTB = tris(benzimidazolyl-2-methyl)amine), which shows high selectivity and stability for the catalytic reduction of CO2 to CO in a water-containing system driven by visible light, with turnover number (TON) and turnover frequency (TOF) values of 1179 and 0.032 s-1, respectively, and selectivity to CO of 97%.	N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)-4-((4-fluorobenzyl)oxy)pyridine-2,6-dicarboxamide	198-201	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-25
28613850-3	2017	Herein, we report a Co(II)-based homogeneous catalyst, [Co(NTB)CH3CN](ClO4)2 (1, NTB = tris(benzimidazolyl-2-methyl)amine), which shows high selectivity and stability for the catalytic reduction of CO2 to CO in a water-containing system driven by visible light, with turnover number (TON) and turnover frequency (TOF) values of 1179 and 0.032 s-1, respectively, and selectivity to CO of 97%.	Carbon Monoxide	198-200	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-25
28613850-3	2017	Herein, we report a Co(II)-based homogeneous catalyst, [Co(NTB)CH3CN](ClO4)2 (1, NTB = tris(benzimidazolyl-2-methyl)amine), which shows high selectivity and stability for the catalytic reduction of CO2 to CO in a water-containing system driven by visible light, with turnover number (TON) and turnover frequency (TOF) values of 1179 and 0.032 s-1, respectively, and selectivity to CO of 97%.	Water	213-218	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-25
28613850-3	2017	Herein, we report a Co(II)-based homogeneous catalyst, [Co(NTB)CH3CN](ClO4)2 (1, NTB = tris(benzimidazolyl-2-methyl)amine), which shows high selectivity and stability for the catalytic reduction of CO2 to CO in a water-containing system driven by visible light, with turnover number (TON) and turnover frequency (TOF) values of 1179 and 0.032 s-1, respectively, and selectivity to CO of 97%.	Carbon Monoxide	205-207	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-25
28617591-0	2017	Control of Interchain Antiferromagnetic Coupling in Porous Co(II)-Based Metal-Organic Frameworks by Tuning the Aromatic Linker Length: How Far Does Magnetic Interaction Propagate?	Metals	72-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-64
28678922-0	2017	Two novel Co(II) complexes with two different Schiff bases: inhibiting growth of human skin cancer cells.	Schiff Bases	46-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-16
28668885-7	2017	TX-1123 bound to the COX2 molecule, and the oxygen atom of the 4-cyclopentene-1,3-dione region of TX-1123 interacted with Cys26 and Gln447 of COX2.	4-cyclopentene-1,3-dione	63-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	142-146
28668885-7	2017	TX-1123 bound to the COX2 molecule, and the oxygen atom of the 4-cyclopentene-1,3-dione region of TX-1123 interacted with Cys26 and Gln447 of COX2.	2-hydroxyarylidene-4-cyclopentene-1,3-dione	98-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	142-146
28668885-6	2017	The COX2 inhibitory activity of TX-1123 was potent (IC50=1.16x10-6 M), and the ratio of COX1/COX2 inhibition was 13.5.	2-hydroxyarylidene-4-cyclopentene-1,3-dione	32-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-8
28668885-8	2017	CONCLUSION: The TX-1123-binding pocket of COX2 differs from that of the COX2-selective celecoxib-binding pocket.	2-hydroxyarylidene-4-cyclopentene-1,3-dione	16-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-46
28668885-6	2017	The COX2 inhibitory activity of TX-1123 was potent (IC50=1.16x10-6 M), and the ratio of COX1/COX2 inhibition was 13.5.	2-hydroxyarylidene-4-cyclopentene-1,3-dione	32-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-97
28668885-8	2017	CONCLUSION: The TX-1123-binding pocket of COX2 differs from that of the COX2-selective celecoxib-binding pocket.	Celecoxib	87-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-46
28668885-7	2017	TX-1123 bound to the COX2 molecule, and the oxygen atom of the 4-cyclopentene-1,3-dione region of TX-1123 interacted with Cys26 and Gln447 of COX2.	2-hydroxyarylidene-4-cyclopentene-1,3-dione	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-25
28668885-8	2017	CONCLUSION: The TX-1123-binding pocket of COX2 differs from that of the COX2-selective celecoxib-binding pocket.	Celecoxib	87-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-76
28668885-7	2017	TX-1123 bound to the COX2 molecule, and the oxygen atom of the 4-cyclopentene-1,3-dione region of TX-1123 interacted with Cys26 and Gln447 of COX2.	2-hydroxyarylidene-4-cyclopentene-1,3-dione	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	142-146
28668885-9	2017	TX-1123 exhibited a different COX2-interactive mechanism from that of celecoxib.	2-hydroxyarylidene-4-cyclopentene-1,3-dione	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-34
28495310-0	2017	Resveratrol inhibits urban particulate matter-induced COX-2/PGE2 release in human fibroblast-like synoviocytes via the inhibition of activation of NADPH oxidase/ROS/NF-kappaB.	Resveratrol	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-59
28495310-9	2017	Thus, we concluded that resveratrol functions as a suppressor of PM-induced inflammatory signaling pathways by inhibiting COX-2/PGE2 expression.	Resveratrol	24-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-127
28412252-6	2017	Treatment of senesecent cells with a NADPH oxidase inhibitor (VAS-2870) or by a COX inhibitor (indomethacin) reduced oxidative stress, decreased TF activity and expression, and reduced the expression of gp91phox, p47phox and COX-2 and restored the ability of ECs to inhibit effectively platelet aggregation.	3-benzyl-7-(2-benzoxazolyl)thio-1,2,3-triazolo(4,5-d)pyrimidine	62-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	225-230
28412252-6	2017	Treatment of senesecent cells with a NADPH oxidase inhibitor (VAS-2870) or by a COX inhibitor (indomethacin) reduced oxidative stress, decreased TF activity and expression, and reduced the expression of gp91phox, p47phox and COX-2 and restored the ability of ECs to inhibit effectively platelet aggregation.	Indomethacin	95-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	225-230
28495310-0	2017	Resveratrol inhibits urban particulate matter-induced COX-2/PGE2 release in human fibroblast-like synoviocytes via the inhibition of activation of NADPH oxidase/ROS/NF-kappaB.	ros	161-164	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-59
28495310-4	2017	Up-regulation of cyclooxygenase (COX)-2 and its metabolite prostaglandin E2 (PGE2) are implicated in various inflammatory diseases.	Dinoprostone	59-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-39
28495310-4	2017	Up-regulation of cyclooxygenase (COX)-2 and its metabolite prostaglandin E2 (PGE2) are implicated in various inflammatory diseases.	Dinoprostone	77-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-39
28495310-6	2017	In the present study, we demonstrated that resveratrol reduced PM-induced COX-2/PGE2 expression in human FLSs, and attenuated PM-enhanced NADPH oxidase activity and ROS generation.	Resveratrol	43-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
28626213-1	2017	BACKGROUND To observe and demonstrate therapeutic effects and side effects of two selective COX-2 inhibitors, imrecoxib and celecoxib, on patients with axial spondyloarthritis (axSpA) and observe the correlation between imaging scores and serum DKK-1 levels.	Imrecoxib	110-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-97
28407559-5	2017	To investigate the underlying molecular mechanism, we examined the impact of PI3K inhibitors on PG-induced COX-2 expression.	Prostaglandins	96-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-112
28407559-6	2017	Interestingly, COX-2 induction by PGE2 and beraprost, but not PGF2alpha, was enhanced by wortmannin and LY294002.	Dinoprostone	34-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-20
28407559-6	2017	Interestingly, COX-2 induction by PGE2 and beraprost, but not PGF2alpha, was enhanced by wortmannin and LY294002.	Wortmannin	89-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-20
28407559-6	2017	Interestingly, COX-2 induction by PGE2 and beraprost, but not PGF2alpha, was enhanced by wortmannin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	104-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-20
28407559-9	2017	Our current findings imply that PGE2 and PGI2 stimulate COX-2 expression in FDC by inhibiting Akt phosphorylation.	Dinoprostone	32-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-61
28407559-9	2017	Our current findings imply that PGE2 and PGI2 stimulate COX-2 expression in FDC by inhibiting Akt phosphorylation.	Epoprostenol	41-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-61
28411820-5	2017	Moreover, the PtNPs@Co(II)MOFs@PtNPs nanocomposites could directly use as redox tags for charge-generating and electron-transporting with the electron transfer from Co(II) to Co(III).	Cobalt(2+)	20-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	165-171
28561569-1	2017	In this work, the effects of ligand field strength as well as the metal coordination geometry on magnetic anisotropy of pentacoordinated CoII complexes have been investigated using a combined experimental and theoretical approach.	Metals	66-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-141
28630405-7	2017	Increased PG biosynthesis in males was accompanied by elevated cyclooxygenase (COX)-2 expression connected to increased nuclear factor-kappa B activation, and was abolished when LT synthesis was pharmacologically blocked, suggesting that elevated PG production in males might be caused by increased COX-2 expression and by shunting phenomena due to suppressed LT formation.	Prostaglandins	10-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-85
28630405-7	2017	Increased PG biosynthesis in males was accompanied by elevated cyclooxygenase (COX)-2 expression connected to increased nuclear factor-kappa B activation, and was abolished when LT synthesis was pharmacologically blocked, suggesting that elevated PG production in males might be caused by increased COX-2 expression and by shunting phenomena due to suppressed LT formation.	Prostaglandins	10-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	299-304
28561569-2	2017	For that, a strategic design and synthesis of three pentacoordinate CoII complexes [Co(bbp)Cl2] (MeOH) (1), [Co(bbp)Br2] (MeOH) (2), and [Co(bbp)(NCS)2] (3) has been achieved by using the tridentate coordination environment of the ligand in conjunction with the accommodating terminal ligands (i.e., chloride, bromide, and thiocyanate).	co(bbp)cl2	84-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-72
28561569-2	2017	For that, a strategic design and synthesis of three pentacoordinate CoII complexes [Co(bbp)Cl2] (MeOH) (1), [Co(bbp)Br2] (MeOH) (2), and [Co(bbp)(NCS)2] (3) has been achieved by using the tridentate coordination environment of the ligand in conjunction with the accommodating terminal ligands (i.e., chloride, bromide, and thiocyanate).	Methanol	97-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-72
28561569-2	2017	For that, a strategic design and synthesis of three pentacoordinate CoII complexes [Co(bbp)Cl2] (MeOH) (1), [Co(bbp)Br2] (MeOH) (2), and [Co(bbp)(NCS)2] (3) has been achieved by using the tridentate coordination environment of the ligand in conjunction with the accommodating terminal ligands (i.e., chloride, bromide, and thiocyanate).	co(bbp)br2	109-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-72
28561569-2	2017	For that, a strategic design and synthesis of three pentacoordinate CoII complexes [Co(bbp)Cl2] (MeOH) (1), [Co(bbp)Br2] (MeOH) (2), and [Co(bbp)(NCS)2] (3) has been achieved by using the tridentate coordination environment of the ligand in conjunction with the accommodating terminal ligands (i.e., chloride, bromide, and thiocyanate).	Methanol	122-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-72
28626213-1	2017	BACKGROUND To observe and demonstrate therapeutic effects and side effects of two selective COX-2 inhibitors, imrecoxib and celecoxib, on patients with axial spondyloarthritis (axSpA) and observe the correlation between imaging scores and serum DKK-1 levels.	Celecoxib	124-133	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-97
28561569-2	2017	For that, a strategic design and synthesis of three pentacoordinate CoII complexes [Co(bbp)Cl2] (MeOH) (1), [Co(bbp)Br2] (MeOH) (2), and [Co(bbp)(NCS)2] (3) has been achieved by using the tridentate coordination environment of the ligand in conjunction with the accommodating terminal ligands (i.e., chloride, bromide, and thiocyanate).	co(bbp)	84-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-72
28626213-12	2017	Selective COX-2 inhibitors imrecoxib and celecoxib had no obvious effects on serum DKK-1 levels.	Imrecoxib	27-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
28561569-2	2017	For that, a strategic design and synthesis of three pentacoordinate CoII complexes [Co(bbp)Cl2] (MeOH) (1), [Co(bbp)Br2] (MeOH) (2), and [Co(bbp)(NCS)2] (3) has been achieved by using the tridentate coordination environment of the ligand in conjunction with the accommodating terminal ligands (i.e., chloride, bromide, and thiocyanate).	Chlorides	300-308	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-72
28561569-2	2017	For that, a strategic design and synthesis of three pentacoordinate CoII complexes [Co(bbp)Cl2] (MeOH) (1), [Co(bbp)Br2] (MeOH) (2), and [Co(bbp)(NCS)2] (3) has been achieved by using the tridentate coordination environment of the ligand in conjunction with the accommodating terminal ligands (i.e., chloride, bromide, and thiocyanate).	Bromides	310-317	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-72
28285462-5	2017	In vitro anti-inflammatory activity was evaluated through the inhibition of 5-LOX-catalyzed leukotriene B4 (LTB4) formation in human neutrophils and inhibition of COX-1- and COX-2-catalyzed prostaglandin E2 (PGE2) formation in human whole blood.	Dinoprostone	190-206	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	174-179
28561569-2	2017	For that, a strategic design and synthesis of three pentacoordinate CoII complexes [Co(bbp)Cl2] (MeOH) (1), [Co(bbp)Br2] (MeOH) (2), and [Co(bbp)(NCS)2] (3) has been achieved by using the tridentate coordination environment of the ligand in conjunction with the accommodating terminal ligands (i.e., chloride, bromide, and thiocyanate).	thiocyanate	323-334	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-72
28534627-0	2017	Highly Stable and Regenerative Metal-Organic Framework Designed by Multiwalled Divider Installation Strategy for Detection of Co(II) Ions and Organic Aromatics in Water.	Metals	31-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-132
28534627-0	2017	Highly Stable and Regenerative Metal-Organic Framework Designed by Multiwalled Divider Installation Strategy for Detection of Co(II) Ions and Organic Aromatics in Water.	Water	163-168	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-132
28573307-1	2017	We report a combined experimental characterization and theoretical modeling of the hexa-coordinated high-spin Co(ii) complex cis-[Co(hfac)2(H2O)2] (I).	[co(hfac)	129-138	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-115
28573307-1	2017	We report a combined experimental characterization and theoretical modeling of the hexa-coordinated high-spin Co(ii) complex cis-[Co(hfac)2(H2O)2] (I).	Water	140-143	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-115
30920519-9	2017	Moreover, nanodexa inhibited COX-2 expression induced by PMA+A23187 in Jurkat cells after 24-48 h incubation in the 10-8-10-5 M concentration range, while dexamethasone was effective only at 10-5 M after 48 h treatment.	Calcimycin	61-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34
28775861-1	2017	In the title compound, [Co(C57H52N6O6)], the central CoII atom is coordinated by four pyrrole N atoms of the porphyrin core and one O atom of the crown ether.	co(c57h52n6o6)	24-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-57
28775861-1	2017	In the title compound, [Co(C57H52N6O6)], the central CoII atom is coordinated by four pyrrole N atoms of the porphyrin core and one O atom of the crown ether.	pyrrole n	86-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-57
28775861-1	2017	In the title compound, [Co(C57H52N6O6)], the central CoII atom is coordinated by four pyrrole N atoms of the porphyrin core and one O atom of the crown ether.	Porphyrins	109-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-57
28547007-1	2017	Simple ML2 [M = Fe(ii), Co(ii), Ni(ii)] complexes obtained from a perfluoroalkylamide derivative of 4-aminophenyl-2,2",6,2"-terpyridine spontaneously, yet anion selectively, self-assemble into gels, which manifest an unprecedented rapid gel strength recovery, viz.	perfluoroalkylamide	66-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-30
28547007-1	2017	Simple ML2 [M = Fe(ii), Co(ii), Ni(ii)] complexes obtained from a perfluoroalkylamide derivative of 4-aminophenyl-2,2",6,2"-terpyridine spontaneously, yet anion selectively, self-assemble into gels, which manifest an unprecedented rapid gel strength recovery, viz.	4-aminophenyl-2,2",6,2"-terpyridine	100-135	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-21
28547007-1	2017	Simple ML2 [M = Fe(ii), Co(ii), Ni(ii)] complexes obtained from a perfluoroalkylamide derivative of 4-aminophenyl-2,2",6,2"-terpyridine spontaneously, yet anion selectively, self-assemble into gels, which manifest an unprecedented rapid gel strength recovery, viz.	4-aminophenyl-2,2",6,2"-terpyridine	100-135	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-30
28547007-1	2017	Simple ML2 [M = Fe(ii), Co(ii), Ni(ii)] complexes obtained from a perfluoroalkylamide derivative of 4-aminophenyl-2,2",6,2"-terpyridine spontaneously, yet anion selectively, self-assemble into gels, which manifest an unprecedented rapid gel strength recovery, viz.	4-aminophenyl-2,2",6,2"-terpyridine	100-135	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-29
28509540-0	2017	Characterization of the High-Spin Co(II) Intermediate Species of the O2-Evolving Co4O4 Cubic Molecules.	Oxygen	69-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-40
28509540-0	2017	Characterization of the High-Spin Co(II) Intermediate Species of the O2-Evolving Co4O4 Cubic Molecules.	co4o4	81-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-40
28509540-8	2017	Additionally, a possible role of the symmetry of the Co(II) species and a proposed model that explains its formation during the O2-evolving process of the Co4O4 cubic molecules are discussed.	Oxygen	128-130	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-58
28509540-8	2017	Additionally, a possible role of the symmetry of the Co(II) species and a proposed model that explains its formation during the O2-evolving process of the Co4O4 cubic molecules are discussed.	co4o4	155-160	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-58
28402673-12	2017	In conclusion, ACL enhances the therapeutic and anticancer efficacy of MTX, when coencapsulated into fucose-anchored LPHNPs, as confirmed by cell viability and serum angiogenesis (IL-6, TNF-alpha, IL-1beta, COX2, and MMP1) at both transcript and proteome level.	Methotrexate	71-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	207-211
28402673-12	2017	In conclusion, ACL enhances the therapeutic and anticancer efficacy of MTX, when coencapsulated into fucose-anchored LPHNPs, as confirmed by cell viability and serum angiogenesis (IL-6, TNF-alpha, IL-1beta, COX2, and MMP1) at both transcript and proteome level.	Fucose	101-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	207-211
28315455-7	2017	While 7,8-DHF treatment and exercise individually mitigated TBI-induced effects, administration of 7,8-DHF concurrently with exercise facilitated memory performance and augmented levels of markers of cell energy metabolism viz., PGC-1alpha, COII and AMPK.	6,7-dihydroxyflavone	99-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	241-245
28411407-1	2017	A new series of 1,2-diaryl-4-substituted-benzylidene-5-4H-imidazolone derivatives 10a-h was designed and synthesized for evaluation as selective COX-2 inhibitors, anti-inflammatory agents and as analgesic agents.	1,2-diaryl-4-substituted-benzylidene-5-4h-imidazolone	16-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-150
28427813-0	2017	Novel pyrazoles and pyrazolo[1,2-a]pyridazines as selective COX-2 inhibitors; Ultrasound-assisted synthesis, biological evaluation, and DFT calculations.	Pyrazoles	6-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-65
28427813-0	2017	Novel pyrazoles and pyrazolo[1,2-a]pyridazines as selective COX-2 inhibitors; Ultrasound-assisted synthesis, biological evaluation, and DFT calculations.	pyrazolo[1,2-a]pyridazines	20-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-65
28427813-3	2017	Herein, we report the design and synthesis of a series of pyrazoles and pyrazolo[1,2-a]pyridazines with selective COX-2 inhibitory activity and in vivo anti-inflammatory effect.	Pyrazoles	58-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-119
28427813-3	2017	Herein, we report the design and synthesis of a series of pyrazoles and pyrazolo[1,2-a]pyridazines with selective COX-2 inhibitory activity and in vivo anti-inflammatory effect.	pyrazolo[1,2-a]pyridazines	72-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-119
28346830-7	2017	A combination of DHA and ASA efficiently enhanced heterodimer formations of PPARalpha and RXRalpha and increased the expression of neurotrophic factors PSD-95, brain-derived neurotrophic factor (BDNF), and glial cell-derived neurotrophic factor (GDNF), while inhibiting NFkappaB and COX2.	Docosahexaenoic Acids	17-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	283-287
28346830-7	2017	A combination of DHA and ASA efficiently enhanced heterodimer formations of PPARalpha and RXRalpha and increased the expression of neurotrophic factors PSD-95, brain-derived neurotrophic factor (BDNF), and glial cell-derived neurotrophic factor (GDNF), while inhibiting NFkappaB and COX2.	Aspirin	25-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	283-287
28591155-9	2017	In protocol 2, seven volunteers were administered COX-2 inhibitor celecoxib (200 mg orally twice daily) for five days.	Celecoxib	66-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-55
28517938-0	2017	Glutamate Ligation in the Ni(II)- and Co(II)-Responsive Escherichia coli Transcriptional Regulator, RcnR.	Glutamic Acid	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-44
28517938-1	2017	Escherichia coli RcnR (resistance to cobalt and nickel regulator, EcRcnR) is a metal-responsive repressor of the genes encoding the Ni(II) and Co(II) exporter proteins RcnAB by binding to PRcnAB.	Cobalt	37-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	143-149
28517938-1	2017	Escherichia coli RcnR (resistance to cobalt and nickel regulator, EcRcnR) is a metal-responsive repressor of the genes encoding the Ni(II) and Co(II) exporter proteins RcnAB by binding to PRcnAB.	Nickel	48-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	143-149
28517938-1	2017	Escherichia coli RcnR (resistance to cobalt and nickel regulator, EcRcnR) is a metal-responsive repressor of the genes encoding the Ni(II) and Co(II) exporter proteins RcnAB by binding to PRcnAB.	Metals	79-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	143-149
28517938-2	2017	The DNA binding affinity is weakened when the cognate ions Ni(II) and Co(II) bind to EcRcnR in a six-coordinate site that features a (N/O)5S ligand donor-atom set in distinct sites: while both metal ions are bound by the N terminus, Cys35, and His64, Co(II) is additionally bound by His3.	Nickel(2+)	59-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	251-257
28517938-2	2017	The DNA binding affinity is weakened when the cognate ions Ni(II) and Co(II) bind to EcRcnR in a six-coordinate site that features a (N/O)5S ligand donor-atom set in distinct sites: while both metal ions are bound by the N terminus, Cys35, and His64, Co(II) is additionally bound by His3.	CHEMBL3739852	138-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-76
28517938-2	2017	The DNA binding affinity is weakened when the cognate ions Ni(II) and Co(II) bind to EcRcnR in a six-coordinate site that features a (N/O)5S ligand donor-atom set in distinct sites: while both metal ions are bound by the N terminus, Cys35, and His64, Co(II) is additionally bound by His3.	Metals	193-198	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-76
28517938-6	2017	X-ray absorption spectroscopy was used to assess the structural changes in the Ni(II), Co(II), and Zn(II) binding sites of Glu   Ala and Glu   Cys variants at both positions.	Glutamic Acid	123-126	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-93
28517938-6	2017	X-ray absorption spectroscopy was used to assess the structural changes in the Ni(II), Co(II), and Zn(II) binding sites of Glu   Ala and Glu   Cys variants at both positions.	Alanine	129-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-93
28517938-6	2017	X-ray absorption spectroscopy was used to assess the structural changes in the Ni(II), Co(II), and Zn(II) binding sites of Glu   Ala and Glu   Cys variants at both positions.	Glutamic Acid	137-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-93
28517938-6	2017	X-ray absorption spectroscopy was used to assess the structural changes in the Ni(II), Co(II), and Zn(II) binding sites of Glu   Ala and Glu   Cys variants at both positions.	Cysteine	143-146	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-93
28517938-12	2017	The spectroscopic and functional data obtained on the mutants were used to calculate models of the metal-site structures of EcRcnR bound to Ni(II), Co(II), and Zn(II).	Metals	99-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	148-154
28670490-0	2017	Dehydrocostus lactone, a natural sesquiterpene lactone, suppresses the biological characteristics of glioma, through inhibition of the NF-kappaB/COX-2 signaling pathway by targeting IKKbeta.	dehydrocostus lactone	0-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-150
28670490-0	2017	Dehydrocostus lactone, a natural sesquiterpene lactone, suppresses the biological characteristics of glioma, through inhibition of the NF-kappaB/COX-2 signaling pathway by targeting IKKbeta.	sesquiterpene lactone	33-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-150
28670490-7	2017	Furthermore, our results fully demonstrate that DHE significantly suppressed COX-2 expression by inhibiting the phosphorylation of IKKbeta via targeting the ATP-binding site, thereby abrogating NF-kappaB binding and p300 recruitment to COX-2 promoter.	dehydrocostus lactone	48-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-82
28670490-7	2017	Furthermore, our results fully demonstrate that DHE significantly suppressed COX-2 expression by inhibiting the phosphorylation of IKKbeta via targeting the ATP-binding site, thereby abrogating NF-kappaB binding and p300 recruitment to COX-2 promoter.	dehydrocostus lactone	48-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	236-241
28670490-7	2017	Furthermore, our results fully demonstrate that DHE significantly suppressed COX-2 expression by inhibiting the phosphorylation of IKKbeta via targeting the ATP-binding site, thereby abrogating NF-kappaB binding and p300 recruitment to COX-2 promoter.	Adenosine Triphosphate	157-160	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-82
28390993-1	2017	New molecular hybrids combining benzothiophene or its bioisostere benzofuran with rhodanine were synthesized as potential dual COX-2/5-LOX inhibitors.	benzothiophene	32-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	127-132
28390993-1	2017	New molecular hybrids combining benzothiophene or its bioisostere benzofuran with rhodanine were synthesized as potential dual COX-2/5-LOX inhibitors.	benzofuran	66-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	127-132
28390993-1	2017	New molecular hybrids combining benzothiophene or its bioisostere benzofuran with rhodanine were synthesized as potential dual COX-2/5-LOX inhibitors.	Rhodanine	82-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	127-132
28500957-0	2017	Design &amp; synthesis of novel oxazolone &amp; triazinone derivatives and their biological evaluation as COX-2 inhibitors.	Oxazolone	32-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-111
28500957-0	2017	Design &amp; synthesis of novel oxazolone &amp; triazinone derivatives and their biological evaluation as COX-2 inhibitors.	Adenosine Monophosphate	8-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-111
28500957-0	2017	Design &amp; synthesis of novel oxazolone &amp; triazinone derivatives and their biological evaluation as COX-2 inhibitors.	triazinone	48-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-111
28500957-1	2017	A new series of oxazolones and triazinones were designed and synthesized and evaluated against both COX-1 and COX-2 enzymes.	Oxazolone	16-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-115
28500957-1	2017	A new series of oxazolones and triazinones were designed and synthesized and evaluated against both COX-1 and COX-2 enzymes.	triazinones	31-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-115
28500957-3	2017	Most of the derivatives showed good inhibitory activity against COX-2 enzyme specifically compounds IIIc, IIIe, IVd and IVg with IC50 values 0.024, 0.019, 0.011 and 0.014microM compared to celecoxib as reference drug with IC50 value of 0.05microM.	Celecoxib	189-198	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-69
28533298-0	2017	The COX-2/PGE2/EP3/Gi/o/cAMP/GSIS Pathway in the Islet: The Beat Goes On.	Cyclic AMP	24-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
28432625-7	2017	The enhanced catalytic activity of CoFe2O4/OMC nanocomposites compared to that of CoFe2O4 nanoparticles could be attributable to the increased adsorption capacity and accelerated redox cycles between Co(III)/Co(II) and Fe(III)/Fe(II).	cobalt ferrite	35-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	208-214
28432625-7	2017	The enhanced catalytic activity of CoFe2O4/OMC nanocomposites compared to that of CoFe2O4 nanoparticles could be attributable to the increased adsorption capacity and accelerated redox cycles between Co(III)/Co(II) and Fe(III)/Fe(II).	2'-O-methylcytidine 5'-monophosphate	43-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	208-214
28432625-7	2017	The enhanced catalytic activity of CoFe2O4/OMC nanocomposites compared to that of CoFe2O4 nanoparticles could be attributable to the increased adsorption capacity and accelerated redox cycles between Co(III)/Co(II) and Fe(III)/Fe(II).	cobalt ferrite	82-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	208-214
28285462-5	2017	In vitro anti-inflammatory activity was evaluated through the inhibition of 5-LOX-catalyzed leukotriene B4 (LTB4) formation in human neutrophils and inhibition of COX-1- and COX-2-catalyzed prostaglandin E2 (PGE2) formation in human whole blood.	Dinoprostone	208-212	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	174-179
28285462-9	2017	All the studied arylxanthones were ineffective to prevent the formation of PGE2 catalyzed by COX-2, up to the maximum concentration of 100 muM.	Dinoprostone	75-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-98
28393249-2	2017	Cyclooxygenase (COX)-2 is the key enzyme catalyzing prostaglandin synthesis and is involved in breast cancer progression and metastasis.	Prostaglandins	52-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-22
28415390-0	2017	Synthesis, spectroscopic and DNA binding ability of CoII, NiII, CuII and ZnII complexes of Schiff base ligand (E)-1-(((1H-benzo[d]imidazol-2-yl)methylimino)methyl)naphthalen-2-ol.	Schiff Bases	91-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-56
28415390-0	2017	Synthesis, spectroscopic and DNA binding ability of CoII, NiII, CuII and ZnII complexes of Schiff base ligand (E)-1-(((1H-benzo[d]imidazol-2-yl)methylimino)methyl)naphthalen-2-ol.	(e)-1-(((1h-benzo[d]imidazol-2-yl)methylimino)methyl)naphthalen-2-ol	110-178	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-56
29442025-9	2017	We found that sinomenine suppressed not only NO and PGE2 production but also iNOS and COX-2 expression in IL-1beta-induced RAFLS.	sinomenine	14-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-91
28513135-1	2017	A new Co(II)-based MOF, {[Co2(tzpa)(OH)(H2O)2] DMF}n (1) (H3tzpa = 5-(4-(tetrazol-5-yl)phenyl)isophthalic acid), was constructed by employing a tetrazolyl-carboxyl ligand H3tzpa.	h3tzpa	58-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	6-11
27388291-5	2017	To illustrate the utility of our approach, we re-analyze individual participant data from 29 randomized placebo-controlled studies on the cardiovascular risk of Vioxx, a Cox-2 selective nonsteroidal anti-inflammatory drug approved by the FDA in 1999 for the management of pain and withdrawn from the market in 2004.	rofecoxib	161-166	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	170-175
28325708-4	2017	During leaching process, glucose was oxidized into monocarboxylic acid with reduction of Co(III) to Co(II).	Glucose	25-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-106
28325708-4	2017	During leaching process, glucose was oxidized into monocarboxylic acid with reduction of Co(III) to Co(II).	monocarboxylic acid	51-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-106
28513135-1	2017	A new Co(II)-based MOF, {[Co2(tzpa)(OH)(H2O)2] DMF}n (1) (H3tzpa = 5-(4-(tetrazol-5-yl)phenyl)isophthalic acid), was constructed by employing a tetrazolyl-carboxyl ligand H3tzpa.	5-(4-(tetrazol-5-yl)phenyl)isophthalic acid	67-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	6-11
28513135-1	2017	A new Co(II)-based MOF, {[Co2(tzpa)(OH)(H2O)2] DMF}n (1) (H3tzpa = 5-(4-(tetrazol-5-yl)phenyl)isophthalic acid), was constructed by employing a tetrazolyl-carboxyl ligand H3tzpa.	carboxyl	155-163	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	6-11
28513135-1	2017	A new Co(II)-based MOF, {[Co2(tzpa)(OH)(H2O)2] DMF}n (1) (H3tzpa = 5-(4-(tetrazol-5-yl)phenyl)isophthalic acid), was constructed by employing a tetrazolyl-carboxyl ligand H3tzpa.	h3tzpa	171-177	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	6-11
28561772-0	2017	Chiral Derivatives of Xanthones: Investigation of the Effect of Enantioselectivity on Inhibition of Cyclooxygenases (COX-1 and COX-2) and Binding Interaction with Human Serum Albumin.	Xanthones	22-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	127-132
28561772-2	2017	Herein, we describe in silico studies and in vitro inhibitory assays of cyclooxygenases (COX-1 and COX-2) for different enantiomeric pairs of CDXs.	cdxs	142-146	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-104
28561772-5	2017	All the CDXs evaluated exhibited COX-1 and COX-2 inhibition potential as predicted.	cdxs	8-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
28638773-5	2017	Interaction of this novel free base with CoII resulted in Co[iso-10-H-[CF3)8TpOMePC], a CoII 10-hydro isocorrole.	co[iso-10-h-[cf3)8tpomepc	58-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-45
28638773-5	2017	Interaction of this novel free base with CoII resulted in Co[iso-10-H-[CF3)8TpOMePC], a CoII 10-hydro isocorrole.	co[iso-10-h-[cf3)8tpomepc	58-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-92
28536229-3	2017	On clinical history, she indicated that 3 weeks prior, she had been initiated on a cyclooygenase-2 (COX-2) inhibitor, celecoxib, for her osteoarthritis of her knees.	Celecoxib	118-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-105
28587064-0	2017	Prostaglandin E2-Induced COX-2 Expressions via EP2 and EP4 Signaling Pathways in Human LoVo Colon Cancer Cells.	Dinoprostone	0-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-30
28587064-10	2017	Inhibition of EP2 and EP4 shows that PGE2 induces protein expression of COX-2 through EP2 and EP4 receptors in LoVo colon cancer cells.	Dinoprostone	37-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
28398602-0	2017	Heptacoordinate CoII Complex: A New Architecture for Photochemical Hydrogen Production.	Hydrogen	67-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-20
28441011-6	2017	In this work, we show that terpyridine ligand functionalization allows tuning the redox potentials of the Co(III)/Co(II), Co(II)/Co(I), and Co(I)/Co(I) (tpy) - couples over a 1 V range.	2,2':6',2''-Terpyridine	27-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-120
28069127-0	2017	Application of dahlia-like molybdenum disulfide nanosheets for solid phase extraction of Co(II) in vegetable and water samples.	molybdenum disulfide	27-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-95
28181858-9	2017	TNFalpha stimulation increased expression of IL-6 at both RNA and protein level as well as upregulated COX2 gene expression and PTGES1.Stimulation with both INFgamma and TNFalpha resulted in significant increase in PGE2 levels in cell culture medium.	Dinoprostone	215-219	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-107
28425546-1	2017	An unexpected substitution of the anionic chelating ligands at the MII centre by a neutral tripodal ligand has been observed in the reaction of MnII, CoII, NiII and CuII hexafluoroacetylacetonates (hfac) with tris(2-pyridyl)phosphine (Py3P) or its oxide (Py3P = O).	tris(2-pyridyl)phosphine	209-233	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	150-154
28471399-0	2017	Brazilian Green Propolis Extract Synergizes with Protoporphyrin IX-mediated Photodynamic Therapy via Enhancement of Intracellular Accumulation of Protoporphyrin IX and Attenuation of NF-kappaB and COX-2.	protoporphyrin IX	49-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	197-202
28471399-11	2017	The protein expression levels of p-IKKalpha/beta, NF-kappaB and COX-2 were upregulated by PpIX-PDT but significantly attenuated when in combination with BGP extract.	protoporphyrin IX	90-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-69
28471399-11	2017	The protein expression levels of p-IKKalpha/beta, NF-kappaB and COX-2 were upregulated by PpIX-PDT but significantly attenuated when in combination with BGP extract.	BETA-GALACTOSE-6-PHOSPHATE	153-156	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-69
28288820-0	2017	Resveratrol inhibits BK-induced COX-2 transcription by suppressing acetylation of AP-1 and NF-kappaB in human rheumatoid arthritis synovial fibroblasts.	Resveratrol	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-37
28288820-3	2017	Here, we investigated the mechanisms underlying BK-induced COX-2 expression which is modulated by resveratrol/Sirt1 in human rheumatoid arthritis synovial fibroblasts (RASFs).	Resveratrol	98-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-64
28288820-4	2017	We found that BK-induced COX-2 protein and mRNA expression associated with PGE2 synthesis, and promoter activity was mediated through B2R receptors, which were attenuated by selective B2R antagonist Hoe140 or transfection with B2R siRNA.	Dinoprostone	75-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-30
28288820-6	2017	Up-regulation of Sirt1 by resveratrol suppressed the BK-induced COX-2/PGE2 production through inhibiting the interaction of AP-1 and NF-kappaB with COX-2 promoter in RASFs.	Resveratrol	26-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-69
28288820-6	2017	Up-regulation of Sirt1 by resveratrol suppressed the BK-induced COX-2/PGE2 production through inhibiting the interaction of AP-1 and NF-kappaB with COX-2 promoter in RASFs.	Resveratrol	26-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	148-153
28288820-7	2017	BK-induced COX-2/PGE2 expression is mediated through a B2R-PKCmu-dependent MAPKs, AP-1, and NF-kappaB cascade.	Dinoprostone	17-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-16
28288820-8	2017	Resveratrol inhibited the phosphorylation and acetylation of p65, c-Jun, and Fos and reduced the binding to the COX-2 promoter, thereby attenuated the COX-2 expression.	Resveratrol	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-117
28288820-8	2017	Resveratrol inhibited the phosphorylation and acetylation of p65, c-Jun, and Fos and reduced the binding to the COX-2 promoter, thereby attenuated the COX-2 expression.	Resveratrol	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-156
28443665-6	2017	The derivatives with nonredox active metal centers could accept four electrons on the conjugated macrocycle, while the CoII complex was characterized by a single one-electron oxidation and five reductions in DMSO.	Dimethyl Sulfoxide	208-212	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-123
28546767-13	2017	CONCLUSION: These findings suggest that CGRP expression in the synovial fibroblasts is regulated by the COX-2/PGE2 pathway and that elevation of synovial CGRP levels may contribute to OA pain.	Dinoprostone	110-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
28415726-3	2017	Indeed, cyclin D1, COX-2, iNOS and c-Myc mRNA levels are upregulated following PGE2 treatment.	Dinoprostone	79-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-24
28441011-6	2017	In this work, we show that terpyridine ligand functionalization allows tuning the redox potentials of the Co(III)/Co(II), Co(II)/Co(I), and Co(I)/Co(I) (tpy) - couples over a 1 V range.	2,2':6',2''-Terpyridine	27-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-128
28418202-1	2017	Two series of benzodioxole-pyrazole hybrids were synthesized and the IC50 values for in vitro inhibition of the enzymes cyclooxygenase 1/2 (COX-1, COX-2) and 5-lipoxygenase (5-LOX) were investigated.	Benzodioxoles	14-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-152
28464017-2	2017	Current techniques limit radiosynthesis to analogs of the COX-2 inhibitors with fluorine-18 added via a carbon chain, or on an aromatic position which renders the radiolabeled analog less specific towards COX-2, resulting in tracers with low in vivo stability or specificity.	Fluorine-18	80-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
28418202-6	2017	A molecular docking study was performed to investigate the possible binding mode of compounds 11, 17, and 26 with the active sites of the COX-2 and 5-LOX enzymes, where they showed nearly the same binding pattern as that of celecoxib and meclofenamic acid, respectively.	Celecoxib	224-233	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	138-143
28212885-2	2017	Here, we report that although catecholamines, mediators of systemic sympathetic activity, display only weak immunosuppressive impact on their own, their combination with inflammatory signals leads to the induction of COX-2 and multiple COX-2-dependent suppressive factors in human myeloid cells and cancer tissues.	Catecholamines	30-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	217-222
28418202-6	2017	A molecular docking study was performed to investigate the possible binding mode of compounds 11, 17, and 26 with the active sites of the COX-2 and 5-LOX enzymes, where they showed nearly the same binding pattern as that of celecoxib and meclofenamic acid, respectively.	Meclofenamic Acid	238-255	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	138-143
28370254-6	2017	The bipyrazole 10 and the pyranopyrazole 27 could be considered as the most active members in this study, being nearly equiactive to celecoxib, besides their obvious selective COX-2 inhibition, high safety margin, and predicted pharmacokinetic (ADME-T) suitability for oral use.	bipyrazole	4-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	176-181
28370254-6	2017	The bipyrazole 10 and the pyranopyrazole 27 could be considered as the most active members in this study, being nearly equiactive to celecoxib, besides their obvious selective COX-2 inhibition, high safety margin, and predicted pharmacokinetic (ADME-T) suitability for oral use.	pyranopyrazole	26-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	176-181
28212885-2	2017	Here, we report that although catecholamines, mediators of systemic sympathetic activity, display only weak immunosuppressive impact on their own, their combination with inflammatory signals leads to the induction of COX-2 and multiple COX-2-dependent suppressive factors in human myeloid cells and cancer tissues.	Catecholamines	30-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	236-241
28212885-3	2017	Human macrophages exposed to epinephrine and TNFalpha, or macrophages generated in 6day cultures in the presence of epinephrine, expressed high levels of COX-2, IDO and IL-10, and strongly suppressed both the proliferation and IFNgamma production of CD8+ T cells.	Epinephrine	29-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	154-159
28212885-4	2017	These suppressive effects of epinephrine were counteracted by celecoxib, a selective inhibitor of COX-2 activity, which inhibited the induction of immunosuppressive factors (including the elevated expression of COX-2 itself) and the ability of epinephrine-exposed macrophages to suppress CD8+ T cell responses.	Epinephrine	29-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-103
28212885-4	2017	These suppressive effects of epinephrine were counteracted by celecoxib, a selective inhibitor of COX-2 activity, which inhibited the induction of immunosuppressive factors (including the elevated expression of COX-2 itself) and the ability of epinephrine-exposed macrophages to suppress CD8+ T cell responses.	Epinephrine	29-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	211-216
28202625-6	2017	Interestingly, COX2-mediated prostaglandin E2 (PGE2) production suppresses the antitumor immunity through a PTGER4 receptor, thereby contributing to HCC progression.	Dinoprostone	29-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-19
28202625-6	2017	Interestingly, COX2-mediated prostaglandin E2 (PGE2) production suppresses the antitumor immunity through a PTGER4 receptor, thereby contributing to HCC progression.	Dinoprostone	47-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-19
28202625-8	2017	The gut microbiota-driven COX2 pathway produced the lipid mediator PGE2 in senescent HSCs in the tumor microenvironment, which plays a pivotal role in suppressing antitumor immunity, suggesting that PGE2 and its receptor may be novel therapeutic targets for noncirrhotic NASH-associated HCC.	Dinoprostone	67-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-30
28202625-8	2017	The gut microbiota-driven COX2 pathway produced the lipid mediator PGE2 in senescent HSCs in the tumor microenvironment, which plays a pivotal role in suppressing antitumor immunity, suggesting that PGE2 and its receptor may be novel therapeutic targets for noncirrhotic NASH-associated HCC.	Dinoprostone	199-203	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-30
28212885-4	2017	These suppressive effects of epinephrine were counteracted by celecoxib, a selective inhibitor of COX-2 activity, which inhibited the induction of immunosuppressive factors (including the elevated expression of COX-2 itself) and the ability of epinephrine-exposed macrophages to suppress CD8+ T cell responses.	Celecoxib	62-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-103
28212885-4	2017	These suppressive effects of epinephrine were counteracted by celecoxib, a selective inhibitor of COX-2 activity, which inhibited the induction of immunosuppressive factors (including the elevated expression of COX-2 itself) and the ability of epinephrine-exposed macrophages to suppress CD8+ T cell responses.	Celecoxib	62-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	211-216
28212885-5	2017	The activation of the COX-2/PGE2 system and COX-2-dependent suppressive events were also observed in ex vivo human breast and colon cancer explant cultures and were similarly counteracted by celecoxib.	Dinoprostone	28-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-27
28212885-5	2017	The activation of the COX-2/PGE2 system and COX-2-dependent suppressive events were also observed in ex vivo human breast and colon cancer explant cultures and were similarly counteracted by celecoxib.	Celecoxib	191-200	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-27
28212885-5	2017	The activation of the COX-2/PGE2 system and COX-2-dependent suppressive events were also observed in ex vivo human breast and colon cancer explant cultures and were similarly counteracted by celecoxib.	Celecoxib	191-200	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-49
28212885-7	2017	The current demonstration of the interplay between inflammation and the induction of immunosuppressive factors by catecholamines suggest a contextual impact of stress, helping to explain variable results of epidemiologic studies of the link between sympathetic activity and cancer progression, and implicating COX-2 blockade as a potential means to mitigate stress-related immune suppression.	Catecholamines	114-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	310-315
28529668-6	2017	The CoII complexes derived from the tetramethyltetraaza[14]annulene ligand are easier to prepare than cobalt(II) porphyrins and present a similar catalytic carbene radical reactivity but are more active.	tetramethyltetraaza[14]annulene	36-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-8
28285845-11	2017	COX-2 expression in cervical biopsies declined from pre-treatment to the end of treatment with celecoxib; it did not change with placebo.	Celecoxib	95-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
28083807-1	2017	New phthalonitrile compound with Schiff base, carbothioamide and thiazole moieties as substituents and its corresponding metal-free and metallophthalocyanines (Zn(II), Ni(II), Co(II), and Cu(II)) were synthesized and characterized for the first time.	1,2-benzenedicarbonitrile	4-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	176-181
28083807-1	2017	New phthalonitrile compound with Schiff base, carbothioamide and thiazole moieties as substituents and its corresponding metal-free and metallophthalocyanines (Zn(II), Ni(II), Co(II), and Cu(II)) were synthesized and characterized for the first time.	Metals	121-126	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	176-181
28436418-0	2017	Oxoaporphine Metal Complexes (CoII, NiII, ZnII) with High Antitumor Activity by Inducing Mitochondria-Mediated Apoptosis and S-phase Arrest in HepG2.	oxoaporphine	0-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-34
28436418-0	2017	Oxoaporphine Metal Complexes (CoII, NiII, ZnII) with High Antitumor Activity by Inducing Mitochondria-Mediated Apoptosis and S-phase Arrest in HepG2.	Metals	13-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-34
28436418-1	2017	Three new oxoaporphine Co(II), Ni(II) and Zn(II) complexes 1-3 have been synthesized and fully characterized.	oxoaporphine	10-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-29
28436418-1	2017	Three new oxoaporphine Co(II), Ni(II) and Zn(II) complexes 1-3 have been synthesized and fully characterized.	Zinc	42-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-29
28537665-9	2017	Furthermore, overexpression of miR-138 suppressed the protein levels of p65, COX-2 and IL6 in human OA chondrocytes and chondrogenic SW1353 cells.	mir-138	31-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-82
27403856-6	2017	Moreover, we also found that stromal-derived PGE2, acting as a stimulator of IL-1 epithelial expression was one of the factors that promote the acquisition of motile properties by epithelial cells and the maintenance of a COX-2/PGE2-dependent inflammatory condition.	Dinoprostone	45-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	222-227
27403856-6	2017	Moreover, we also found that stromal-derived PGE2, acting as a stimulator of IL-1 epithelial expression was one of the factors that promote the acquisition of motile properties by epithelial cells and the maintenance of a COX-2/PGE2-dependent inflammatory condition.	Dinoprostone	228-232	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	222-227
28409286-0	2017	The dependence on ammonia pretreatment of N-O activation by Co(II) sites in zeolites: a DFT and ab initio molecular dynamics study.	Ammonia	18-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-66
28409286-2	2017	It is based on cluster and periodic density functional theory modeling for relevant {[Co(II)(NH3)n]-NO} adducts, where Co(II) means a cobalt cation embedded either in a periodic model of chabasite (CHA) zeolite or in model clusters.	Cobalt	134-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-92
28409286-2	2017	It is based on cluster and periodic density functional theory modeling for relevant {[Co(II)(NH3)n]-NO} adducts, where Co(II) means a cobalt cation embedded either in a periodic model of chabasite (CHA) zeolite or in model clusters.	Cobalt	134-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-125
28409286-4	2017	By relating calculated NO frequencies to experimental FTIR spectra, it was shown that the forms of {Co(II)-NO} adducts comprising three or four ammonia co-ligands dominate the spectrum taken in ammonia-saturation conditions while forms with two NH3 ligands prevail under intermediate ammonia saturation.	Ammonia	144-151	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-106
28409286-4	2017	By relating calculated NO frequencies to experimental FTIR spectra, it was shown that the forms of {Co(II)-NO} adducts comprising three or four ammonia co-ligands dominate the spectrum taken in ammonia-saturation conditions while forms with two NH3 ligands prevail under intermediate ammonia saturation.	Ammonia	194-201	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-106
28409286-4	2017	By relating calculated NO frequencies to experimental FTIR spectra, it was shown that the forms of {Co(II)-NO} adducts comprising three or four ammonia co-ligands dominate the spectrum taken in ammonia-saturation conditions while forms with two NH3 ligands prevail under intermediate ammonia saturation.	Ammonia	194-201	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-106
28409286-5	2017	Finally, this work confirms the critical dependence of Co(II) activation ability towards NO upon the center donor properties, reinforced by ligation of strong donor ammonia ligands.	Ammonia	165-172	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-60
28347141-3	2017	Here we demonstrate that elemental halogens quantitatively oxidize coordinatively unsaturated Co(II) ions in a robust azolate metal-organic framework (MOF) to produce stable and safe-to-handle Co(III) materials featuring terminal Co(III)-halogen bonds.	azolate	118-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-100
28347141-3	2017	Here we demonstrate that elemental halogens quantitatively oxidize coordinatively unsaturated Co(II) ions in a robust azolate metal-organic framework (MOF) to produce stable and safe-to-handle Co(III) materials featuring terminal Co(III)-halogen bonds.	Metals	126-131	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-100
28347141-3	2017	Here we demonstrate that elemental halogens quantitatively oxidize coordinatively unsaturated Co(II) ions in a robust azolate metal-organic framework (MOF) to produce stable and safe-to-handle Co(III) materials featuring terminal Co(III)-halogen bonds.	co(iii)	193-200	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-100
28347141-3	2017	Here we demonstrate that elemental halogens quantitatively oxidize coordinatively unsaturated Co(II) ions in a robust azolate metal-organic framework (MOF) to produce stable and safe-to-handle Co(III) materials featuring terminal Co(III)-halogen bonds.	co(iii)	230-237	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-100
28347141-3	2017	Here we demonstrate that elemental halogens quantitatively oxidize coordinatively unsaturated Co(II) ions in a robust azolate metal-organic framework (MOF) to produce stable and safe-to-handle Co(III) materials featuring terminal Co(III)-halogen bonds.	Halogens	35-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-100
28529668-6	2017	The CoII complexes derived from the tetramethyltetraaza[14]annulene ligand are easier to prepare than cobalt(II) porphyrins and present a similar catalytic carbene radical reactivity but are more active.	cobalt(ii) porphyrins	102-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-8
28529668-6	2017	The CoII complexes derived from the tetramethyltetraaza[14]annulene ligand are easier to prepare than cobalt(II) porphyrins and present a similar catalytic carbene radical reactivity but are more active.	carbene	156-163	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-8
28375018-1	2017	The preparations of related mononuclear and binuclear Co(II) complexes with a quasi-identical local C3v symmetry using a cryptand organic ligand are reported.	CHEMBL4081585	100-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-60
28378861-0	2017	Effect of the apical ligand on the geometry and magnetic properties of copper(ii)/mesoxalate trinuclear units.	mesoxalic acid	82-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-80
28358208-0	2017	Imidazole-Appended Macrocyclic Complexes of Fe(II), Co(II), and Ni(II) as ParaCEST Agents.	imidazole	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-57
28375018-4	2017	The weak magnitude of the antiferromagnetic exchange coupling, analyzed using a combination of broken-symmetry density functional theory and wave function based calculations, is ascribed to the weak overlap between the singly occupied orbitals because of the local C3v symmetry of the Co(II) ions; the organic ligand was found to contribute to the exchange coupling as the azido bridge that directly links the Co(II) ions.	3',5-diazido-2',3'-dideoxyuridine	373-378	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	285-291
28358208-1	2017	The solution chemistry and solid state structures of the Co(II), Fe(II), and Ni(II) complexes of N,N"-bis(imidazole-2-ylmethyl)-4,10-diaza-15-crown-5 (HINO) are reported.	n,n"-bis(imidazole-2-ylmethyl)-4,10-diaza-15-crown-5	97-149	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-62
28529781-1	2017	The asymmetric unit of the title one-dimensional polymeric compound, {[Co(C10H11O2)2(H2O)3] 2H2O} n , contains one CoII cation situated on a centre of inversion, one-half of a coordinating water mol-ecule, one 2,4,6-tri-methyl-benzoate (TMB) anion together with one coordinating and one non-coordinating water mol-ecule; the TMB anion acts as a monodentate ligand.	[co(c10h11o2)2(h2o)3] 2h2o	70-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-119
28358208-1	2017	The solution chemistry and solid state structures of the Co(II), Fe(II), and Ni(II) complexes of N,N"-bis(imidazole-2-ylmethyl)-4,10-diaza-15-crown-5 (HINO) are reported.	hino	151-155	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-62
28358208-2	2017	The Co(II) and Ni(II) complexes of HINO are the first examples of paraCEST agents (paramagnetic chemical exchange saturation transfer) that feature exchangeable imidazole NH protons.	imidazole	161-170	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
28420140-7	2017	The expression of COX-2 and IL-17 were significantly lower in samples treated with OLE + EC-LPS compared with those treated with EC-LPS alone (0.80 +- 0.15 arbitrary units (a.u.)	ole + ec-lps	83-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-23
28420140-7	2017	The expression of COX-2 and IL-17 were significantly lower in samples treated with OLE + EC-LPS compared with those treated with EC-LPS alone (0.80 +- 0.15 arbitrary units (a.u.)	ec-lps	89-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-23
28529781-3	2017	The CoII atom is coordinated by two TMB anions and two water mol-ecules in the basal plane, while another water mol-ecule bridges the CoII atoms in the axial directions, forming polymeric chains running along [001].	1,2,4,5-tetramethoxybenzene	36-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-8
28529781-3	2017	The CoII atom is coordinated by two TMB anions and two water mol-ecules in the basal plane, while another water mol-ecule bridges the CoII atoms in the axial directions, forming polymeric chains running along [001].	Water	55-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-8
28129624-9	2017	What"s more, we examined that Erianin might play its role in angiogenesis through down-regulating phosphorylation of JAK2/STAT3, inhibiting its downstream target genes MMP-2/-9 and some inflammatory mediators (COX-2, HIF-1alpha and IL-6), which were all induced by IDO.	Erianin	30-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	210-215
28539818-11	2017	Our findings suggest that isoflurane pretreatment could attenuate tPA-exaggerated brain ischemic injury, by reducing tPA-induced LRP/NF-kappaB/Cox-2 in endothelial cells, endothelial MMP-2 and MMP-9 activation, and subsequent pro-apoptotic molecule in neurons after OGD/R.	Isoflurane	26-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	143-148
28903343-0	2017	A study on the anti-tumor mechanism of total flavonoids from Radix Tetrastigmae against additional cell line based on COX-2-mediated Wnt/beta-catenin signaling pathway.	Flavonoids	45-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-123
28369131-3	2017	We performed an in vivo model of PD using the neurotoxin 1-methyl-4-phenyl-1, 2,3,6-tetrahydropyridine (MPTP) and our results clearly showed that TO901317 administration reduces all of the inflammatory markers involved in PD such as iNOS and COX2, IkappaB-alpha and NF-kappaB.	T0901317	146-154	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	242-246
27826802-3	2017	The balance of evidence suggests that cardiovascular risk correlates with cyclooxygenase (COX)-2 selectivity, and the low COX-2 selectivity of naproxen results in a lower cardiovascular risk than that of other NSAIDs.	Naproxen	143-151	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-127
28373419-9	2017	Furthermore, western blotting data showed that E-cadherin, beta-catenin, VEGF and COX-2 expressions were suppressed by isosteviol derivative 10C in HepG2 cells.	isosteviol	119-129	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
28362295-2	2017	The re-crystallization of (1S) in toluene at 277 K resulted in a concomitant formation of a solvent-free polymorph, CoII(3,5-DBSQ)2(DBPy)2 (1).	Toluene	34-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-120
28362295-2	2017	The re-crystallization of (1S) in toluene at 277 K resulted in a concomitant formation of a solvent-free polymorph, CoII(3,5-DBSQ)2(DBPy)2 (1).	dbpy	132-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-120
27973724-0	2017	Investigations on Antioxidant, Antiproliferative and COX-2 Inhibitory Potential of Alkaloids from Anthocephalus cadamba (Roxb.)	Alkaloids	83-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-58
28236449-6	2017	Molecular docking studies showed appreciable binding of new pyridazinone analogues with the amino acids present at the active site of hCOX-2 enzyme.	2-phenyl-3(2H)-pyridazinone	60-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-140
28394629-0	2017	Synthesis and molecular docking of new imidazoquinazolinones as analgesic agents and selective COX-2 inhibitors.	imidazoquinazolinones	39-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-100
31961595-1	2017	Four metalloporphyrin dimers linked by bridging amide-bonded xanthene moieties and that contain either MnIII , CoII , NiII , or CuII metal centers were synthesized.	Metalloporphyrins	5-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	111-115
28402056-3	2017	The aim of this study was to evaluate the gene transcription pattern of prostaglandin (PG) synthesis enzymes (cyclooxygenase [COX2], PTGES-1 and PGFS) in the endometrium of bitches with or without endometritis.	Prostaglandins	72-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-131
28101847-7	2017	Furthermore, AZ11645373 inhibited induction of mRNA encoding for COX-2 (PTGS2) suggesting that its anti-inflammatory potential is not limited to suppression of IL-8 production.	AZ 11645373	13-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-70
28979307-0	2017	QSAR Modeling of COX -2 Inhibitory Activity of Some Dihydropyridine and Hydroquinoline Derivatives Using Multiple Linear Regression (MLR) Method.	1,4-dihydropyridine	52-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-23
28979307-0	2017	QSAR Modeling of COX -2 Inhibitory Activity of Some Dihydropyridine and Hydroquinoline Derivatives Using Multiple Linear Regression (MLR) Method.	quinoline	72-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-23
28979307-1	2017	COX-2 inhibitory activities of some 1,4-dihydropyridine and 5-oxo-1,4,5,6,7,8-hexahydroquinoline derivatives were modeled by quantitative structure-activity relationship (QSAR) using stepwise-multiple linear regression (SW-MLR) method.	1,4-dihydropyridine	36-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
28979307-1	2017	COX-2 inhibitory activities of some 1,4-dihydropyridine and 5-oxo-1,4,5,6,7,8-hexahydroquinoline derivatives were modeled by quantitative structure-activity relationship (QSAR) using stepwise-multiple linear regression (SW-MLR) method.	SCHEMBL5322983	60-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
28375409-1	2017	The Vioxx Gastrointestinal Outcomes Research (VIGOR) trial, published in 2000, was the first to raise concerns that NSAIDs (specifically, the COX-2 selective inhibitor rofecoxib) might be associated with a higher risk for cardiovascular (CV) events.	rofecoxib	4-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	142-147
28375409-1	2017	The Vioxx Gastrointestinal Outcomes Research (VIGOR) trial, published in 2000, was the first to raise concerns that NSAIDs (specifically, the COX-2 selective inhibitor rofecoxib) might be associated with a higher risk for cardiovascular (CV) events.	rofecoxib	168-177	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	142-147
28283800-3	2017	While the selective COX-2 inhibitor celecoxib showed anti-neoplastic activity against several malignant tumors, its effects against LGG remain to be elucidated.	Celecoxib	36-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-25
27666139-1	2017	OBJECTIVES: The role of celecoxib in preventing and treating tumors has attracted broad attention in recent years because of its selective and specific inhibition of COX-2 activity.	Celecoxib	24-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	166-171
28157665-5	2017	Formation of threshold level of 8-hydroxyoctanoic acid was quantified from COX-catalyzed DGLA peroxidation in the cancer cells that overexpress COX-2 and their delta-5-desaturases were knocked down by shRNA transfection.	8-hydroxyoctanoic acid	32-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	144-149
28157665-5	2017	Formation of threshold level of 8-hydroxyoctanoic acid was quantified from COX-catalyzed DGLA peroxidation in the cancer cells that overexpress COX-2 and their delta-5-desaturases were knocked down by shRNA transfection.	8,11,14-Eicosatrienoic Acid	89-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	144-149
28402056-3	2017	The aim of this study was to evaluate the gene transcription pattern of prostaglandin (PG) synthesis enzymes (cyclooxygenase [COX2], PTGES-1 and PGFS) in the endometrium of bitches with or without endometritis.	Prostaglandins	87-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-131
28503262-1	2017	The cobalt (Co(II)) ion is a main component of alloys and considered to be carcinogenic, especially due to the carcinogenic and toxicological effects in the aquatic environment.	Cobalt	4-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-18
28503262-2	2017	The toxic trace of the Co(II) detection was conducted using the infrared photodiode electrode (IPDE) using a working electrode, via the cyclic and square-wave anodic stripping voltammetry.	ipde	95-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-29
28263588-2	2017	This behavior is not observed with the analogous bipyridine and pyrazolylpyridine complexes (3 and 4), which display an electrochemical signature typical of CoIII systems: two sequential one-electron reductions to CoII at -0.4 V and CoI at -1.0 to -1.3 V versus Fc0/+.	2,2'-Dipyridyl	49-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	157-161
28263588-2	2017	This behavior is not observed with the analogous bipyridine and pyrazolylpyridine complexes (3 and 4), which display an electrochemical signature typical of CoIII systems: two sequential one-electron reductions to CoII at -0.4 V and CoI at -1.0 to -1.3 V versus Fc0/+.	2-(1H-Pyrazol-3-Yl)Pyridine	64-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	157-161
28043910-0	2017	Metformin inhibits castration-induced EMT in prostate cancer by repressing COX2/PGE2/STAT3 axis.	Metformin	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-79
28043910-0	2017	Metformin inhibits castration-induced EMT in prostate cancer by repressing COX2/PGE2/STAT3 axis.	Dinoprostone	80-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-79
28043910-5	2017	In addition, we showed the effects of metformin on the expression of genes involved in EMT through repressing the levels of COX2, PGE2 and phosphorylated STAT3.	Metformin	38-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	124-128
28043910-6	2017	Furthermore, inactivating COX2 abolishes metformin"s regulatory effects and exogenously administered PGE2 is capable of enhancing STAT3 phosphorylation and expression of EMT biomarker.	Metformin	41-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-30
28043910-7	2017	We propose that metformin represses prostate cancer EMT and metastasis through targeting the COX2/PGE2/STAT3 axis.	Metformin	16-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-97
28043910-7	2017	We propose that metformin represses prostate cancer EMT and metastasis through targeting the COX2/PGE2/STAT3 axis.	Dinoprostone	98-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-97
28118518-4	2017	The alteration of the D value by N-bound axial CN ligands, upon association with cyanometallates, was also assessed for heptacoordinated FeII as well as for related NiII and CoII derivatives.	Nitrogen	33-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	174-178
30090515-5	2017	The results showed that low concentration arsenite increased the expressions of proliferative factors BCL2, cyclin D1, COX-2, MMP1 and PCNA in SV-HUC-1 cells, and ATF2 siRNA partly decreased the expressions of BCL2, cyclin D1, and COX-2.	arsenite	42-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-124
30090515-5	2017	The results showed that low concentration arsenite increased the expressions of proliferative factors BCL2, cyclin D1, COX-2, MMP1 and PCNA in SV-HUC-1 cells, and ATF2 siRNA partly decreased the expressions of BCL2, cyclin D1, and COX-2.	arsenite	42-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	231-236
28423516-1	2017	Here we showed that the addition of the COX-2 inhibitor celecoxib improved the antitumor efficacy in colorectal cancer (CRC) of the monoclonal anti-EGFR antibody cetuximab.	Celecoxib	56-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
28251211-0	2017	Slow magnetic relaxation in a Co(ii) octahedral-tetrahedral system formed of a [CoL3]2+ core with L = bis(diphenylphosphanoxido) methane and tetrahedral [CoBr4]2- counter anions.	bis(diphenylphosphanoxido) methane	102-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-36
28251211-0	2017	Slow magnetic relaxation in a Co(ii) octahedral-tetrahedral system formed of a [CoL3]2+ core with L = bis(diphenylphosphanoxido) methane and tetrahedral [CoBr4]2- counter anions.	cobr4	154-159	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-36
28251211-1	2017	A bimetallic Co(ii) compound [Co(dppmO,O)3][CoBr4] consisting of cationic octahedral and anionic tetrahedral units in the crystal lattice shows a sizable magnetic anisotropy and field-supported slow magnetic relaxation with the relaxation time tau = 0.1-0.3 s at T = 1.9 K.	co(dppmo,o)3]	30-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-19
28251211-1	2017	A bimetallic Co(ii) compound [Co(dppmO,O)3][CoBr4] consisting of cationic octahedral and anionic tetrahedral units in the crystal lattice shows a sizable magnetic anisotropy and field-supported slow magnetic relaxation with the relaxation time tau = 0.1-0.3 s at T = 1.9 K.	cobr4	44-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-19
28752712-6	2017	Results: Compared with control group, the expression of COX-2, iNOS and GRP78 in PA group was enhanced to 6.07+-0.73(P&lt;0.05), 3.18+-0.91 (P&lt;0.01) and 3.21+-1.00(P&lt;0.05), respectively.	Palmitic Acid	81-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-61
28752712-7	2017	Compared to control group, the expression of COX-2,iNOS and GRP78 in 100 mumol/L DGPL group was reduced to 2.40+-0.76, 1.60+-0.49 and 1.17 +-0.42 (P&lt;0.05); and 20 mumol DGPL had similar inhibition effect on COX-2 and iNOS elevation induced by PA (P&lt;0.01, P&lt;0.05 respectively).	dgpl	81-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-50
28752712-7	2017	Compared to control group, the expression of COX-2,iNOS and GRP78 in 100 mumol/L DGPL group was reduced to 2.40+-0.76, 1.60+-0.49 and 1.17 +-0.42 (P&lt;0.05); and 20 mumol DGPL had similar inhibition effect on COX-2 and iNOS elevation induced by PA (P&lt;0.01, P&lt;0.05 respectively).	dgpl	81-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	210-215
28752712-7	2017	Compared to control group, the expression of COX-2,iNOS and GRP78 in 100 mumol/L DGPL group was reduced to 2.40+-0.76, 1.60+-0.49 and 1.17 +-0.42 (P&lt;0.05); and 20 mumol DGPL had similar inhibition effect on COX-2 and iNOS elevation induced by PA (P&lt;0.01, P&lt;0.05 respectively).	dgpl	172-176	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-50
28752712-7	2017	Compared to control group, the expression of COX-2,iNOS and GRP78 in 100 mumol/L DGPL group was reduced to 2.40+-0.76, 1.60+-0.49 and 1.17 +-0.42 (P&lt;0.05); and 20 mumol DGPL had similar inhibition effect on COX-2 and iNOS elevation induced by PA (P&lt;0.01, P&lt;0.05 respectively).	Palmitic Acid	246-248	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-50
28752712-9	2017	Conclusion: PA can induce the up-regulated expression of inflammation associated genes COX-2, iNOS and ER stress-associated gene GRP78 in Huh7 cells.	Palmitic Acid	12-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-92
28240885-5	2017	Electronic absorption and infrared spectra indicate that the Lewis acid cations have a minor effect on the electronic structure of the Co(II) ion, which suggests the shifts in redox potential are primarily a result of electrostatic effects due to the cationic charge.	Lewis Acids	61-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-141
28257185-0	2017	Incorporation of Pyrazine and Bipyridine Linkers with High-Spin Fe(II) and Co(II) in a Metal-Organic Framework.	Pyrazines	17-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-81
28257185-0	2017	Incorporation of Pyrazine and Bipyridine Linkers with High-Spin Fe(II) and Co(II) in a Metal-Organic Framework.	2,2'-Dipyridyl	30-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-81
28257185-0	2017	Incorporation of Pyrazine and Bipyridine Linkers with High-Spin Fe(II) and Co(II) in a Metal-Organic Framework.	Metals	87-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-81
28212033-3	2017	This thermochromic transformation in the near-surface region goes along with a loss in preferential surface orientation of free [SCN]- anions and with a pronounced decrease in the complex density; both effects are attributed to the formation of a weakly bound solvation shell around the [Co(II) (NCS)6]4- anion, leading to an effective complex dilution.	thiocyanate	129-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	288-294
28212033-3	2017	This thermochromic transformation in the near-surface region goes along with a loss in preferential surface orientation of free [SCN]- anions and with a pronounced decrease in the complex density; both effects are attributed to the formation of a weakly bound solvation shell around the [Co(II) (NCS)6]4- anion, leading to an effective complex dilution.	)6]4- anion	299-310	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	288-294
28386348-0	2017	Inhibition of COX-2/PGE2 cascade ameliorates cisplatin-induced mesangial cell apoptosis.	Dinoprostone	20-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
28386348-0	2017	Inhibition of COX-2/PGE2 cascade ameliorates cisplatin-induced mesangial cell apoptosis.	Cisplatin	45-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
28386348-6	2017	Interestingly, cisplatin-induced cell apoptosis was accompanied by an upregulation of COX-2 at both mRNA and protein levels in dose- and time-dependent manners.	Cisplatin	15-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-91
28386348-7	2017	Importantly, inhibition of COX-2 via a specific COX-2 inhibitor celecoxib markedly blocked cisplatin-induced mesangial cell apoptosis as evidenced by the decreased number of apoptotic cells, blocked increments of cleaved caspase-3 and Bax, and reversed Bcl-2 downregulation.	Celecoxib	64-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-32
28386348-7	2017	Importantly, inhibition of COX-2 via a specific COX-2 inhibitor celecoxib markedly blocked cisplatin-induced mesangial cell apoptosis as evidenced by the decreased number of apoptotic cells, blocked increments of cleaved caspase-3 and Bax, and reversed Bcl-2 downregulation.	Celecoxib	64-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-53
28386348-7	2017	Importantly, inhibition of COX-2 via a specific COX-2 inhibitor celecoxib markedly blocked cisplatin-induced mesangial cell apoptosis as evidenced by the decreased number of apoptotic cells, blocked increments of cleaved caspase-3 and Bax, and reversed Bcl-2 downregulation.	Cisplatin	91-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-32
28386348-7	2017	Importantly, inhibition of COX-2 via a specific COX-2 inhibitor celecoxib markedly blocked cisplatin-induced mesangial cell apoptosis as evidenced by the decreased number of apoptotic cells, blocked increments of cleaved caspase-3 and Bax, and reversed Bcl-2 downregulation.	Cisplatin	91-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-53
28386348-9	2017	In conclusion, this study indicated that COX-2/PGE2 cascade activation mediated cisplatin-induced mesangial cell apoptosis.	Dinoprostone	47-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-46
28386348-9	2017	In conclusion, this study indicated that COX-2/PGE2 cascade activation mediated cisplatin-induced mesangial cell apoptosis.	Cisplatin	80-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-46
28386348-10	2017	The findings not only offered new insights into the understanding of cisplatin nephrotoxicity but also provided the therapeutic potential by targeting COX-2/PGE2 cascade in treating cisplatin-induced kidney injury.	Dinoprostone	157-161	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-156
28386348-10	2017	The findings not only offered new insights into the understanding of cisplatin nephrotoxicity but also provided the therapeutic potential by targeting COX-2/PGE2 cascade in treating cisplatin-induced kidney injury.	Cisplatin	182-191	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-156
28225613-3	2017	To further investigate this issue and inspired by research in water oxidation, we calculate in the present study the dehydrogenation free energy of aqueous Co2+, which is the free energy change associated with the first step of the water oxidation reaction mechanism of recently investigated model Co(II)-aqua catalysts.	Water	62-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	298-303
28225613-3	2017	To further investigate this issue and inspired by research in water oxidation, we calculate in the present study the dehydrogenation free energy of aqueous Co2+, which is the free energy change associated with the first step of the water oxidation reaction mechanism of recently investigated model Co(II)-aqua catalysts.	Cobalt(2+)	156-160	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	298-303
28225613-3	2017	To further investigate this issue and inspired by research in water oxidation, we calculate in the present study the dehydrogenation free energy of aqueous Co2+, which is the free energy change associated with the first step of the water oxidation reaction mechanism of recently investigated model Co(II)-aqua catalysts.	Water	232-237	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	298-303
28135104-3	2017	Here we report the solution using multiwall carbon nanotubes (MCNTs)@MnO2 nanocomposite cathode integrated with N,N"-bis(salicylidene)ethylenediaminocobalt(II) (CoII-salen) in electrolyte for LABs.	Carbon	44-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	161-165
28135104-3	2017	Here we report the solution using multiwall carbon nanotubes (MCNTs)@MnO2 nanocomposite cathode integrated with N,N"-bis(salicylidene)ethylenediaminocobalt(II) (CoII-salen) in electrolyte for LABs.	manganese dioxide	69-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	161-165
28135104-3	2017	Here we report the solution using multiwall carbon nanotubes (MCNTs)@MnO2 nanocomposite cathode integrated with N,N"-bis(salicylidene)ethylenediaminocobalt(II) (CoII-salen) in electrolyte for LABs.	n,n"-bis(salicylidene)ethylenediaminocobalt	112-155	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	161-165
28135104-5	2017	On the other hand, CoII-salen works as a mobile O2-carrier and accelerates Li2O2 formation through the reaciton of (CoIII-salen)2-O22- + 2Li+ + 2e-   2CoII-salen + Li2O2.	Li2O2	75-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-23
28225611-1	2017	The magnetic properties of pseudotetrahedral Co(II) complexes spawned intense interest after (PPh4)2[Co(SPh)4] was shown to be the first mononuclear transition-metal complex displaying slow relaxation of the magnetization in the absence of a direct current magnetic field.	Metals	160-165	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-51
28225611-6	2017	Notably, the paramagnetic Co(II) complex [Co(SPh)4]2- shows strong axial magnetic anisotropy in 1, with D = -55(1) cm-1 and E/D = 0.00(3), but rhombic anisotropy is seen for 2, with D = +11(1) cm-1 and E/D = 0.18(3).	co(sph)4	42-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-32
28038418-0	2017	Kinetic and thermodynamic studies of the Co(II) and Ni(II) ions removal from aqueous solutions by Ca-Mg phosphates.	ca-mg phosphates	98-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-47
28126288-4	2017	The present work aims to summarize the current approaches adopted for the synthesis of the 1,2,3-triazole and medicinal significance of these architectures as a lead structure for the discovery of drug molecules such as COX-1/COX-2 inhibitors (celecoxib, pyrazofurin), HIV protease inhibitors, CB1 cannabinoid receptor antagonist and much more which are in the pipeline of clinical trials.	Triazoles	91-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	226-231
28126288-4	2017	The present work aims to summarize the current approaches adopted for the synthesis of the 1,2,3-triazole and medicinal significance of these architectures as a lead structure for the discovery of drug molecules such as COX-1/COX-2 inhibitors (celecoxib, pyrazofurin), HIV protease inhibitors, CB1 cannabinoid receptor antagonist and much more which are in the pipeline of clinical trials.	Celecoxib	244-253	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	226-231
28126288-4	2017	The present work aims to summarize the current approaches adopted for the synthesis of the 1,2,3-triazole and medicinal significance of these architectures as a lead structure for the discovery of drug molecules such as COX-1/COX-2 inhibitors (celecoxib, pyrazofurin), HIV protease inhibitors, CB1 cannabinoid receptor antagonist and much more which are in the pipeline of clinical trials.	pyrazofurin	255-266	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	226-231
28153724-1	2017	Nonsteroidal anti-inflammatory drugs (NSAIDs), including ibuprofen, are amongst the most commonly used medications and produce their anti-inflammatory and analgesic benefits by blocking cyclooxygenase (COX)-2.	Ibuprofen	57-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	186-208
28153724-5	2017	The ibuprofen salt, ibuprofen arginate (Spididol ) was created to increase drug solubility but we have previously established that it not only effectively blocks COX-2 but also provides an arginine source able to reverse the effects of ADMA in vitro and in vivo.	ibuprofen salt	4-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	162-167
28153724-5	2017	The ibuprofen salt, ibuprofen arginate (Spididol ) was created to increase drug solubility but we have previously established that it not only effectively blocks COX-2 but also provides an arginine source able to reverse the effects of ADMA in vitro and in vivo.	ibuprofen arginine	20-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	162-167
28153724-5	2017	The ibuprofen salt, ibuprofen arginate (Spididol ) was created to increase drug solubility but we have previously established that it not only effectively blocks COX-2 but also provides an arginine source able to reverse the effects of ADMA in vitro and in vivo.	spididol	40-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	162-167
28193829-8	2017	Our data show that binding of sCD83 to MD-2 alters this signaling cascade by rapidly degrading IL-1R-associated kinase-1, leading to induction of the anti-inflammatory mediators IDO, IL-10, and PGE2 in a COX-2-dependent manner.	Dinoprostone	194-198	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	204-209
28273917-6	2017	Inhibition of PGE2 was partially dependent on the reduced levels of PGE2 synthesising enzymes, COX-2 and mPGES-1.	Dinoprostone	14-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-100
28186419-4	2017	In turn, in the Co(II) derivatives, the incorporation of the (Me4cyclam)CoII moiety diminishes the aromaticity of the triazole ring and has a marked effect on the energy and distribution of the LUSO orbital, mostly resident on the Co(II) fragment.	(me4cyclam	61-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-22
28186419-4	2017	In turn, in the Co(II) derivatives, the incorporation of the (Me4cyclam)CoII moiety diminishes the aromaticity of the triazole ring and has a marked effect on the energy and distribution of the LUSO orbital, mostly resident on the Co(II) fragment.	(me4cyclam	61-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	231-237
28186419-4	2017	In turn, in the Co(II) derivatives, the incorporation of the (Me4cyclam)CoII moiety diminishes the aromaticity of the triazole ring and has a marked effect on the energy and distribution of the LUSO orbital, mostly resident on the Co(II) fragment.	Triazoles	118-126	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-22
28195727-7	2017	The hydrogenation activity of Co(II) compounds with redox-innocent phosphine donors involves the Co(0)-Co(II) catalytic mechanism.	phosphine	67-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-36
28195727-7	2017	The hydrogenation activity of Co(II) compounds with redox-innocent phosphine donors involves the Co(0)-Co(II) catalytic mechanism.	phosphine	67-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-109
28195727-7	2017	The hydrogenation activity of Co(II) compounds with redox-innocent phosphine donors involves the Co(0)-Co(II) catalytic mechanism.	co(0)	97-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-36
28195727-7	2017	The hydrogenation activity of Co(II) compounds with redox-innocent phosphine donors involves the Co(0)-Co(II) catalytic mechanism.	co(0)	97-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-109
28127603-0	2017	Luminescent iridium(iii) complexes as COX-2-specific imaging agents in cancer cells.	Iridium	12-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-43
28127603-2	2017	This is the first application of iridium(iii) complexes as imaging agents for COX-2.	Iridium	33-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-83
27864660-1	2017	Celecoxib, a selective cyclooxygenase (COX)-2 inhibitor, is used for the treatment of rheumatoid arthritis and osteoarthritis.	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-45
28033575-7	2017	The ABTS method also had a good anti-interference performance against Co(II) ions.	ABTS diammonium salt	4-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-76
28094049-2	2017	The abnormal expression of COX-2, which is involved in the synthesis of PGE2, was recently reported as a critical determinant for invasiveness of human breast cancer cells.	Dinoprostone	72-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-32
28338176-0	2017	The inhibitory effect of resveratrol on COX-2 expression in human colorectal cancer: a promising therapeutic strategy.	Resveratrol	25-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
28338176-1	2017	OBJECTIVE: The objective of this study is to investigate the mechanism of resveratrol (RSVL) on the inhibitory effect on the expression of COX-2 in human colorectal cancer.	Resveratrol	74-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-144
28338176-1	2017	OBJECTIVE: The objective of this study is to investigate the mechanism of resveratrol (RSVL) on the inhibitory effect on the expression of COX-2 in human colorectal cancer.	Resveratrol	87-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-144
28338176-3	2017	The inhibitory effect induced by RSVL on the COX-2 expression in human colorectal cancer was investigated.	Resveratrol	33-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-50
28338176-8	2017	According to the results from enzyme-linked immunosorbent assay (ELISA) and Western blot, the expression of the COX-2 protein in the observation group treated with RSVL was significantly lower than that in the blank control group; however, results from the observation group and the control group were similar.	Resveratrol	164-168	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-117
28338176-10	2017	CONCLUSIONS: RSVL (in a certain concentration) can suppress the human colorectal cancer through inhibition of COX-2 expression.	Resveratrol	13-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-115
28038418-1	2017	The aim of this work was to study the sorption kinetics and thermodynamics of Co(II) and Ni(II) from aqueous solutions by sorbents on the basis of hydrogen (PD-1) and tertiary (PD-2) Ca-Mg phosphates depending on the solution temperature and sorbents chemical composition.	Hydrogen	147-155	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-84
28038418-1	2017	The aim of this work was to study the sorption kinetics and thermodynamics of Co(II) and Ni(II) from aqueous solutions by sorbents on the basis of hydrogen (PD-1) and tertiary (PD-2) Ca-Mg phosphates depending on the solution temperature and sorbents chemical composition.	Palladium	157-159	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-84
28038418-1	2017	The aim of this work was to study the sorption kinetics and thermodynamics of Co(II) and Ni(II) from aqueous solutions by sorbents on the basis of hydrogen (PD-1) and tertiary (PD-2) Ca-Mg phosphates depending on the solution temperature and sorbents chemical composition.	mg phosphates	186-199	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-84
28038418-2	2017	Kinetic studies of adsorption of Co(II) and Ni(II) ions onto samples of phosphate sorbents were performed in batch experiment at the temperatures 288, 303, 318 and 333 K. The sorbent dose was fixed at 10 g L-1, initial pH value 2.6, and contact time varied from 5 to 600 min.	Phosphates	72-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-39
28038418-6	2017	Thermodynamic studies confirmed the spontaneous and endothermic nature of removal process which indicate that sorption of Co(II) and Ni(II) ions onto both phosphate sorbents is favoured at higher temperatures and has the chemisorptive mechanism.	Phosphates	155-164	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-128
27843000-8	2017	We also demonstrated that cells cultured with histamine increase COX-2 mRNA expression and osthole reduce it.	Histamine	46-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-70
28199187-8	2017	Interestingly, the combined treatment with curcumin and docetaxel modulates the expression of RTKs, PI3K, phospho-AKT, NF-kappa B, p53, and COX-2.	Curcumin	43-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-145
28199187-8	2017	Interestingly, the combined treatment with curcumin and docetaxel modulates the expression of RTKs, PI3K, phospho-AKT, NF-kappa B, p53, and COX-2.	Docetaxel	56-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-145
27178425-5	2017	Selective inhibition of COX-1 with SC-560 preferentially reduced the early reduction in CBF while selective COX-2 inhibition with NS-398 affected only the later response.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	130-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-113
26982261-3	2017	Celecoxib, rofecoxib, and valdecoxib are well-known specific COX-2 inhibiting drugs.	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-66
26982261-3	2017	Celecoxib, rofecoxib, and valdecoxib are well-known specific COX-2 inhibiting drugs.	rofecoxib	11-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-66
26982261-3	2017	Celecoxib, rofecoxib, and valdecoxib are well-known specific COX-2 inhibiting drugs.	valdecoxib	26-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-66
26982261-4	2017	Recently, polmacoxib, a COX-2/CA-II dual inhibitor has been approved by the Korean FDA.	CG100649	10-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
27843000-0	2017	Changes in gene expression induced by histamine, fexofenadine and osthole: Expression of histamine H1 receptor, COX-2, NF-kappaB, CCR1, chemokine CCL5/RANTES and interleukin-1beta in PBMC allergic and non-allergic patients.	osthol	66-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-117
27669541-8	2017	Sucrose activated autophagy blocked IL-1beta-induced apoptosis and mRNA expression of MMP-13, COX-2, and IL-6 in human OA chondrocytes.	Sucrose	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-99
27178425-7	2017	Our results suggest that the long-lasting oligemia following CSD consists of at least two distinct temporal phases, mediated by preferential actions of COX-1- and COX-2-derived prostanoids: an initial phase mediated by COX-1 that involves TXA2 followed by a later phase, mediated by COX-2 and PGF2alpha.	Prostaglandins	177-188	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	163-168
27677346-8	2017	In addition, curcumin and IFN-beta/RA combination inhibited the expression of COX-2 and up-regulated GADD153.	Curcumin	13-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-83
27677346-8	2017	In addition, curcumin and IFN-beta/RA combination inhibited the expression of COX-2 and up-regulated GADD153.	Tretinoin	35-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-83
28231533-0	2017	Synthesis, characterization and DNA binding/cleavage, protein binding and cytotoxicity studies of Co(II), Ni(II), Cu(II) and Zn(II) complexes of aminonaphthoquinone.	aminonaphthoquinone	145-164	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-104
27897337-2	2017	Above 200 K, solids as well as solutions of 1 exhibit thermally induced spin-crossover (SCO) from the ls to the high-spin (hs) CoII semiquinonate state instead of the frequently observed valence tautomerism from ls CoIII catecholate to hs CoII semiquinonate.	hassio	123-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	127-131
27897337-3	2017	DFT calculations demonstrate that the (closed shell) CoIII catecholate suffers from a triplet instability leading to the ls CoII semiquinonate ground state.	catecholate(2-)	59-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-57
27897337-3	2017	DFT calculations demonstrate that the (closed shell) CoIII catecholate suffers from a triplet instability leading to the ls CoII semiquinonate ground state.	leucylserine	121-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-57
28052039-0	2017	COX-2/mPGES-1/PGE2 cascade activation mediates uric acid-induced mesangial cell proliferation.	Dinoprostone	14-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
28052039-0	2017	COX-2/mPGES-1/PGE2 cascade activation mediates uric acid-induced mesangial cell proliferation.	Uric Acid	47-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
28052039-3	2017	The present study was undertaken to examined the role of inflammatory cascade of COX-2/mPGES-1/PGE2 in UA-induced MC proliferation.	Uric Acid	103-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-86
28052039-5	2017	Interestingly, UA-induced cell proliferation was accompanied with the upregulation of COX-2 and mPGES-1 at both mRNA and protein levels.	Uric Acid	15-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-91
28106394-1	2017	The structure and properties of metallo-supramolecular polyelectrolytes (MEPEs) self-assembled from rigid 2,6-bis(2-pyridyl)pyrimidine and the metal ions FeII and CoII are presented.	Metals	32-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	163-167
27935181-3	2017	The periodic connection of a one-dimensional anionic tungstoselenate molecular wire building block with a CoII ion is used to construct the crystalline material.	tungstoselenate	53-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-110
28231533-1	2017	The Co(II), Ni(II), Cu(II) and Zn(II) complexes of an aminonaphthoquinone ligand (L) have been prepared and characterized using analytical and spectral techniques.	aminonaphthoquinone	54-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
28231533-3	2017	The results indicate that Co(II), Ni(II) and Zn(II) complexes possess tetrahedral geometry while Cu(II) complex exhibits square planar structure.	Zinc	45-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-32
28231533-3	2017	The results indicate that Co(II), Ni(II) and Zn(II) complexes possess tetrahedral geometry while Cu(II) complex exhibits square planar structure.	cu(ii)	97-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-32
28454270-2	2017	There is a strong correlation between COX-2 expression and PGE2 production in tissues from CRC patients, suggesting an important role for COX-2 on the regulation of PGE2 production.	Dinoprostone	59-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-43
28454270-2	2017	There is a strong correlation between COX-2 expression and PGE2 production in tissues from CRC patients, suggesting an important role for COX-2 on the regulation of PGE2 production.	Dinoprostone	165-169	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-43
28454270-2	2017	There is a strong correlation between COX-2 expression and PGE2 production in tissues from CRC patients, suggesting an important role for COX-2 on the regulation of PGE2 production.	Dinoprostone	165-169	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	138-143
28454270-5	2017	The present study aimed to investigate the role of FosB on the COX-2/PGE2 axis in CRC cells with high COX-2 expression levels.	Dinoprostone	69-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-107
28344655-0	2017	Interactions among COX-2, GPIIIa and P2Y1 variants are associated with aspirin responsiveness and adverse events in patients with ischemic stroke.	Aspirin	71-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-24
28772606-0	2017	Magnetic Anisotropy and Field-induced Slow  Relaxation of Magnetization in Tetracoordinate CoII Compound [Co(CH3-im)2Cl2].	co(ch3-im)2cl2	106-120	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-95
28772606-1	2017	Static and dynamic magnetic properties of the tetracoordinate CoII complex [Co(CH3-im)2Cl2], (1, CH3-im = N-methyl-imidazole), studied using thorough analyses of magnetometry, and High-Frequency and -Field EPR (HFEPR) measurements, are reported.	co(ch3-im)2cl2	76-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-66
28772606-1	2017	Static and dynamic magnetic properties of the tetracoordinate CoII complex [Co(CH3-im)2Cl2], (1, CH3-im = N-methyl-imidazole), studied using thorough analyses of magnetometry, and High-Frequency and -Field EPR (HFEPR) measurements, are reported.	1-methylimidazole	106-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-66
28231855-8	2017	Lastly the BRAFV600E A375 and NRASQ61R SK-MEL-2 melanoma cell lines were used to evaluate the effect of COX-2 inhibition by celecoxib on expression of PD-L1 in vitro.	Celecoxib	124-133	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
28231855-14	2017	Lastly, inhibition of COX-2 activity by celecoxib down-regulated the expression of PD-L1 in both BRAFV600E A375 and NRASQ61R SK-MEL-2 melanoma cell lines.	Celecoxib	40-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-27
28191552-2	2017	In one case, involving an aromatic dibromide substrate in NpRdhA, a novel CoII-Br interaction was observed using EPR, suggesting a mechanism involving a [CoXR] adduct.	Dibromide	35-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-78
28177256-0	2017	Synthesis, Structure, and Magnetic Electrochemical Properties of a Family of Tungstoarsenates Containing Just CoII Centers or Both CoII and FeIII Centers.	tungstoarsenate	77-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-114
28177256-0	2017	Synthesis, Structure, and Magnetic Electrochemical Properties of a Family of Tungstoarsenates Containing Just CoII Centers or Both CoII and FeIII Centers.	tungstoarsenate	77-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-135
28182416-4	2017	Their characterization clearly revealed that epsilon-Keggin-type cobaltomolybdate units, [epsilon-CoMo12O40]n-, constructed by a central CoIIO4 tetrahedron and 12 surrounding MoO6 octahedra, are linked with CoII to form 3D frameworks.	cobaltomolybdate	65-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-141
27837994-2	2017	Compounds 19 and 27 exhibited the highest potency and selectivity for COX-2 inhibitory activity (IC50 = 1.21 and 1.13 muM, respectively; selectivity index (COX-1/COX-2) = 6.52 and 7.61, respectively) in comparison to the reference drug celecoxib (COX-2 IC50 = 0.88 muM; selectivity index (COX-1/COX-2) = 8.31).	Celecoxib	236-245	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-75
27837994-5	2017	The molecular docking study of compounds 19 and 27 into COX-2 active site suggested that these hits assumed binding pattern and interactions similar to that of bromocelecoxib (S-58) as a cocrystallized ligand explaining their remarkable COX-2 inhibitory activity and selectivity.	bromocelecoxib	160-174	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-61
27837994-5	2017	The molecular docking study of compounds 19 and 27 into COX-2 active site suggested that these hits assumed binding pattern and interactions similar to that of bromocelecoxib (S-58) as a cocrystallized ligand explaining their remarkable COX-2 inhibitory activity and selectivity.	bromocelecoxib	160-174	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	237-242
28089698-1	2017	A library of fourteen 2-imino-4-thiazolidinone derivatives (1a-1n) has been synthesized and evaluated for in vivo anti-inflammatory activity and effect on ex-vivo COX-2 and TNF-alpha expression.	1a-1n	60-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	163-168
28089698-3	2017	Compound 1k showed a reduction of 68.32% in the level of COX-2 as compared to the indomethacin which exhibited 66.23% inhibition of COX-2.	Indomethacin	82-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-137
28052039-6	2017	Strikingly, inhibition of COX-2 via a specific COX-2 inhibitor NS-398 markedly blocked UA-induced MC proliferation.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	63-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-31
28052039-6	2017	Strikingly, inhibition of COX-2 via a specific COX-2 inhibitor NS-398 markedly blocked UA-induced MC proliferation.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	63-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
28052039-6	2017	Strikingly, inhibition of COX-2 via a specific COX-2 inhibitor NS-398 markedly blocked UA-induced MC proliferation.	Uric Acid	87-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-31
28052039-6	2017	Strikingly, inhibition of COX-2 via a specific COX-2 inhibitor NS-398 markedly blocked UA-induced MC proliferation.	Uric Acid	87-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
28052039-10	2017	In conclusion, our findings indicated that COX-2/mPGES-1/PGE2 cascade activation mediated UA-induced MC proliferation.	Dinoprostone	57-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
28052039-10	2017	In conclusion, our findings indicated that COX-2/mPGES-1/PGE2 cascade activation mediated UA-induced MC proliferation.	Uric Acid	90-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
28080044-2	2017	Three sulfur-containing trigonal bipyramidal Co(II) complexes were synthesized and characterized.	Sulfur	6-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-51
28094522-5	2017	Structural variations were found in the CoII-O bond lengths that range from 1.953(4) to 2.051(3) A; this range in bond lengths were attributed to the differences in the intramolecular hydrogen bonds that surround the hydroxido ligand.	Hydrogen	184-192	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-44
27927986-4	2017	Moreover, GlcN suppressed LPS-induced up-regulation of COX-2, IL-6, and TNF-alpha mRNAs under 25 mm glucose conditions yet did not inhibit up-regulation under 5 mm glucose conditions.	Glucosamine	10-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-60
27007742-2	2017	The major purpose of this research was to develop a novel poly(ethyleneglycol)-block-poly(epsilon-caprolactone) (PEG-b-PCL) nano-sized particles encapsulated with nimesulide (NMS), a selective COX-2 inhibitor, and to evaluate its anticancer activity against MCF-7 breast cancer cells.	poly(ethylene glycol)-block-poly(epsilon-caprolactone)	58-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	193-198
27007742-2	2017	The major purpose of this research was to develop a novel poly(ethyleneglycol)-block-poly(epsilon-caprolactone) (PEG-b-PCL) nano-sized particles encapsulated with nimesulide (NMS), a selective COX-2 inhibitor, and to evaluate its anticancer activity against MCF-7 breast cancer cells.	nimesulide	163-173	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	193-198
28057325-0	2017	Design, synthesis and biological screening of some novel celecoxib and etoricoxib analogs with promising COX-2 selectivity, anti-inflammatory activity and gastric safety profile.	Celecoxib	57-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-110
28057325-0	2017	Design, synthesis and biological screening of some novel celecoxib and etoricoxib analogs with promising COX-2 selectivity, anti-inflammatory activity and gastric safety profile.	Etoricoxib	71-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-110
28057407-3	2017	While compound 2b showed comparable level of COX-2 selectivity as celecoxib, compound 11b outperformed indomethacin in terms of selectivity towards COX-2 relative to COX-1.	Indomethacin	103-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	148-153
27998828-10	2017	Resveratrol slightly decreased COX-2 expression after 18h but not after 6h, but reduced PGE2 levels after 6h.	Resveratrol	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-36
28002977-4	2017	Log transformed levels of mtDNA coding for MT-CO1 and MT-CO2 were significantly higher among infants of active smokers with higher serum level of cotinine (p &lt; 0.05) and inversely associated with gestational age (p = 0.08; p = 0.02).	Cotinine	146-154	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-60
28002977-6	2017	We identified a dose-dependent increase in the level of MT-CO1 and MT-CO2 associated to increased cord serum cotinine and decreased gestational age.	Cotinine	109-117	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-73
28254043-0	2017	Adsorption of Co(II) from aqueous solutions by water treatment residuals.	Water	47-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-20
28254043-1	2017	A study on the removal of Co(II) from aqueous solutions by water treatment residuals (WTR) was conducted in batch conditions.	Water	59-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-32
28254043-7	2017	The shifting of peaks in FT-IR spectra indicated that Co(II) interacted with the WTR surface through strong covalent bond formation with Fe(Al)-O functional groups.	fe(al)	137-143	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-60
27889630-1	2017	An old anti-inflammatory/analgesic drug called Toradol is a racemic form of Ketorolac (50% R-form and 50% S-form) that blocks the oncogenic RAC-PAK1-COX-2 (cyclooxygenase-2) signaling, through the direct inhibition of RAC by the R-form and of COX-2 by the S-form, eventually down-regulating the production of prostaglandins.	Ketorolac Tromethamine	47-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	149-154
27769779-4	2017	Plumbagin and Celecoxib are two agents that were identified to synergistically kill melanoma cells by inhibiting the COX-2 and STAT3 pathways, which are constitutively activated in up to 70% of melanomas.	plumbagin	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-122
27769779-4	2017	Plumbagin and Celecoxib are two agents that were identified to synergistically kill melanoma cells by inhibiting the COX-2 and STAT3 pathways, which are constitutively activated in up to 70% of melanomas.	Celecoxib	14-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-122
27769779-7	2017	Mechanistically, combination of Celecoxib and Plumbagin decreased melanoma cell proliferation and retarded vascular development of tumors mediated by inhibition of COX-2 and STAT3 leading to decreased levels of key cyclins key on which melanoma cell were dependent for survival.	Celecoxib	32-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	164-169
27569276-6	2017	Intervention was perioperative use of any available COX-2 inhibitors in current practice (celecoxib, parecoxib, or etoricoxib), compared to non-selective NSAIDs, analgesics, or placebo.	Celecoxib	90-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-57
28025110-0	2017	Hypomethylation of inflammatory genes (COX2, EGR1, and SOCS3) and increased urinary 8-nitroguanine in arsenic-exposed newborns and children.	Arsenic	102-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-43
28025110-3	2017	Our previous study reported that prenatal arsenic exposure leads to increased mRNA expression of several genes related to inflammation, including COX2, EGR1, and SOCS3.	Arsenic	42-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	146-150
28025110-4	2017	This study aimed to investigate the effects of arsenic exposure on promoter DNA methylation and mRNA expression of these inflammatory genes (COX2, EGR1, and SOCS3), as well as the generation of 8-nitroguanine, which is a mutagenic DNA lesion involved in inflammation-related carcinogenesis.	Arsenic	47-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	141-145
28025110-5	2017	Prenatally arsenic-exposed newborns had promoter hypomethylation of COX2, EGR1, and SOCS3 in cord blood lymphocytes (p&lt;0.01).	Arsenic	11-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-72
28025110-10	2017	These results indicated that early-life exposure to arsenic causes hypomethylation of COX2, EGR1, and SOCS3, increases mRNA expression of these genes, and increases 8-nitroguanine formation.	Arsenic	52-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-90
27826040-5	2017	Importantly, we identified that NF-kappaB/COX-2/PGE2 axis acted as downstream signaling of caspase 3, mediating proangiogenic response after irradiation.	Dinoprostone	48-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47
28051316-5	2017	Compounds 6 and 7A inhibited COX-2 by 10% and 8%, respectively, at a concentration of 12.5 muM compared to 12% for 1 mM aspirin (the positive control).	Aspirin	120-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34
27889630-1	2017	An old anti-inflammatory/analgesic drug called Toradol is a racemic form of Ketorolac (50% R-form and 50% S-form) that blocks the oncogenic RAC-PAK1-COX-2 (cyclooxygenase-2) signaling, through the direct inhibition of RAC by the R-form and of COX-2 by the S-form, eventually down-regulating the production of prostaglandins.	Ketorolac Tromethamine	47-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	243-248
27889630-1	2017	An old anti-inflammatory/analgesic drug called Toradol is a racemic form of Ketorolac (50% R-form and 50% S-form) that blocks the oncogenic RAC-PAK1-COX-2 (cyclooxygenase-2) signaling, through the direct inhibition of RAC by the R-form and of COX-2 by the S-form, eventually down-regulating the production of prostaglandins.	Ketorolac	76-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	149-154
27889630-1	2017	An old anti-inflammatory/analgesic drug called Toradol is a racemic form of Ketorolac (50% R-form and 50% S-form) that blocks the oncogenic RAC-PAK1-COX-2 (cyclooxygenase-2) signaling, through the direct inhibition of RAC by the R-form and of COX-2 by the S-form, eventually down-regulating the production of prostaglandins.	Ketorolac	76-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	243-248
27889630-1	2017	An old anti-inflammatory/analgesic drug called Toradol is a racemic form of Ketorolac (50% R-form and 50% S-form) that blocks the oncogenic RAC-PAK1-COX-2 (cyclooxygenase-2) signaling, through the direct inhibition of RAC by the R-form and of COX-2 by the S-form, eventually down-regulating the production of prostaglandins.	Prostaglandins	309-323	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	149-154
27889630-7	2017	Thus, the Click Chemistry dramatically boosts the anti-cancer activity of Ketorolac, at least in three ways: increasing its cell-permeability, the anti-PAK1 activity of R-form and anti-COX-2 activity of S-form.	Ketorolac	74-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	185-190
28051870-0	2017	Asymmetric Radical Cyclopropanation of Alkenes with In Situ-Generated Donor-Substituted Diazo Reagents via Co(II)-Based Metalloradical Catalysis.	Alkenes	39-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-112
28051870-0	2017	Asymmetric Radical Cyclopropanation of Alkenes with In Situ-Generated Donor-Substituted Diazo Reagents via Co(II)-Based Metalloradical Catalysis.	diazo reagents	88-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-112
28051870-1	2017	Donor-substituted diazo reagents, generated in situ from sulfonyl hydrazones in the presence of base, can serve as suitable radical precursors for Co(II)-based metalloradical catalysis (MRC).	diazo reagents	18-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-152
28051870-1	2017	Donor-substituted diazo reagents, generated in situ from sulfonyl hydrazones in the presence of base, can serve as suitable radical precursors for Co(II)-based metalloradical catalysis (MRC).	sulfonyl hydrazones	57-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-152
28051870-3	2017	This Co(II)-based metalloradical system represents the first catalytic protocol that can effectively utilize donor-type diazo reagents for asymmetric olefin cyclopropanation.	diazo reagents	120-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	5-10
28051870-3	2017	This Co(II)-based metalloradical system represents the first catalytic protocol that can effectively utilize donor-type diazo reagents for asymmetric olefin cyclopropanation.	Alkenes	150-156	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	5-10
27974694-0	2017	Hormophysa triquerta polyphenol, an elixir that deters CXCR4- and COX2-dependent dissemination destiny of treatment-resistant pancreatic cancer cells.	Polyphenols	21-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-70
28105626-11	2017	After rofecoxib (a COX-2 specific inhibitor) inhibited the expression of COX-2, the expression level of PGE2 was significantly decreased in a dose-dependent manner.	rofecoxib	6-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-24
28105626-11	2017	After rofecoxib (a COX-2 specific inhibitor) inhibited the expression of COX-2, the expression level of PGE2 was significantly decreased in a dose-dependent manner.	rofecoxib	6-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-78
28105626-11	2017	After rofecoxib (a COX-2 specific inhibitor) inhibited the expression of COX-2, the expression level of PGE2 was significantly decreased in a dose-dependent manner.	Dinoprostone	104-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-24
28105626-11	2017	After rofecoxib (a COX-2 specific inhibitor) inhibited the expression of COX-2, the expression level of PGE2 was significantly decreased in a dose-dependent manner.	Dinoprostone	104-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-78
28105626-12	2017	In co-culture system, whose gastric cancer cells expressed positive COX-2, omega-6 could increase angiogenesis of gastric cancer cells(P&lt;0.01), but omega-3 could inhibit such angiogenesis(P&lt;0.01).	omega-6	75-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-73
28105626-14	2017	CONCLUSIONS: The PUFA omega-6 can enhance the angiogenesis via the promotion of proliferation and migration of HUVECs, and COX-2 and PGE2 may play an important role in this process, whereas, the omega-3 can inhibit the angiogenesis through its middle metabolites PGE3 to inhibit the proliferation and migration of HUVECs.	prostaglandin E3	263-267	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-128
27897354-1	2017	An anionic CoII -MOF, (Me2 NH2 )[Co3 (Me2 NH)3 (OH)(SDBA)3 ] (1) (H2 SDBA=4,4"-sulfonyldibenzoic acid) consisting of highly symmetric CoII3 (mu3 -OH) triangles exhibits spin-canting, spin-flop, and easy-plane magnetic anisotropy.	1-ETHOXY-2-(2-METHOXYETHOXY)ETHANE	23-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-15
27897354-1	2017	An anionic CoII -MOF, (Me2 NH2 )[Co3 (Me2 NH)3 (OH)(SDBA)3 ] (1) (H2 SDBA=4,4"-sulfonyldibenzoic acid) consisting of highly symmetric CoII3 (mu3 -OH) triangles exhibits spin-canting, spin-flop, and easy-plane magnetic anisotropy.	co3 (me2 nh	33-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-15
27897354-1	2017	An anionic CoII -MOF, (Me2 NH2 )[Co3 (Me2 NH)3 (OH)(SDBA)3 ] (1) (H2 SDBA=4,4"-sulfonyldibenzoic acid) consisting of highly symmetric CoII3 (mu3 -OH) triangles exhibits spin-canting, spin-flop, and easy-plane magnetic anisotropy.	sdba	52-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-15
27897354-1	2017	An anionic CoII -MOF, (Me2 NH2 )[Co3 (Me2 NH)3 (OH)(SDBA)3 ] (1) (H2 SDBA=4,4"-sulfonyldibenzoic acid) consisting of highly symmetric CoII3 (mu3 -OH) triangles exhibits spin-canting, spin-flop, and easy-plane magnetic anisotropy.	4"-sulfonyldibenzoic acid	76-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-15
28174685-8	2017	Additionally, unlike traditional COX-2 inhibitors, this response rather specifically attenuated PGE2 levels in the presence of inflammation and without lowering levels of other eicosanoids.	Dinoprostone	96-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-38
28035824-3	2017	A comparison of their Kbeta XES spectra with the spectra of cobalt coordination complexes with known oxidation and spin states demonstrates that the low-temperature valence tautomer can be described as a low-spin CoIII configuration and the high-temperature valence tautomer as a high-spin CoII configuration.	Cobalt	60-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	213-217
27916468-6	2017	Four compounds; diphenylthiazole glycine derivatives (15a, 15b) and diphenylimidazolo acetic acid derivatives (19a, 19b), which possess carboxylic acid group exhibited significant activity and selectivity against COX-1 over COX-2.	diphenylthiazole glycine	16-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	224-229
27916468-6	2017	Four compounds; diphenylthiazole glycine derivatives (15a, 15b) and diphenylimidazolo acetic acid derivatives (19a, 19b), which possess carboxylic acid group exhibited significant activity and selectivity against COX-1 over COX-2.	diphenylimidazolo acetic acid	68-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	224-229
27916468-6	2017	Four compounds; diphenylthiazole glycine derivatives (15a, 15b) and diphenylimidazolo acetic acid derivatives (19a, 19b), which possess carboxylic acid group exhibited significant activity and selectivity against COX-1 over COX-2.	Carboxylic Acids	136-151	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	224-229
27916468-7	2017	Of these compounds, (4,5-bis(4-methoxyphenyl)thiazol-2-yl)glycine 15b was the most potent compound against COX-1 with an inhibitory half maximal concentration (IC50) of 0.32muM and a selectivity index (COX-2 IC50/COX-1 IC50) of 28.84.	(4,5-bis(4-methoxyphenyl)thiazol-2-yl)glycine	20-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	202-207
27541797-2	2017	Co(II), Ni(II), Cu(II) and Zn(II) of the synthesized Schiff bases were prepared by using a molar ratio of ligand:metal as 1:1.	Schiff Bases	53-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
27541797-2	2017	Co(II), Ni(II), Cu(II) and Zn(II) of the synthesized Schiff bases were prepared by using a molar ratio of ligand:metal as 1:1.	Metals	113-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
27541797-8	2017	On the basis of the spectral studies, TGA and DFT data an octahedral geometry has been assigned for Co(II), Ni(II), square planar for Cu(II) and tetrahedral for Zn(II) complexes.	Zinc	161-167	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-106
28068952-0	2017	Interaction among COX-2, P2Y1 and GPIIIa gene variants is associated with aspirin resistance and early neurological deterioration in Chinese stroke patients.	Aspirin	74-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-23
27935298-1	2017	A study of the magnetic structure of the [NH2(CH3)2]n[FeIIIMII(HCOO)6]n niccolite-like compounds, with MII = CoII (2) and MnII (3) ions, has been carried out using neutron diffraction and compared with the previously reported FeII-containing compound (1).	(hcoo)6]	62-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-113
28056899-2	2017	We had earlier shown that cyclooxygenase (COX)-2 expression by human or murine breast cancer cells promoted lymphangiogenesis and lymphatic metastasis by upregulating VEGF-C/D production by tumor cells or tumor-associated macrophages primarily due to activation of the prostaglandin receptor EP4 by endogenous PGE2.	Dinoprostone	310-314	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-48
28056899-7	2017	Addition of PGE2 or EP4 agonist, or C3L5-CM individually in the presence of COX-2 inhibitor, or EP4 antagonist, restored tube formation, reinforcing the role of EP4 on RMLEC in tubulogenesis.	Dinoprostone	12-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-81
28115830-1	2017	OBJECTIVE: Prostaglandin E2 (PGE2) synthesis is modulated by COX2.	Dinoprostone	11-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-65
28115830-1	2017	OBJECTIVE: Prostaglandin E2 (PGE2) synthesis is modulated by COX2.	Dinoprostone	29-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-65
28115830-2	2017	Changes in PGE2 could be used to quantify the COX2 inhibition after ibuprofen administration.	Dinoprostone	11-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-50
28115830-2	2017	Changes in PGE2 could be used to quantify the COX2 inhibition after ibuprofen administration.	Ibuprofen	68-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-50
28115830-3	2017	This study investigated the pharmacokinetic and pharmacodynamic relationships for COX2 inhibition according to three formulations of ibuprofen in healthy male subjects.	Ibuprofen	133-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-86
27935298-1	2017	A study of the magnetic structure of the [NH2(CH3)2]n[FeIIIMII(HCOO)6]n niccolite-like compounds, with MII = CoII (2) and MnII (3) ions, has been carried out using neutron diffraction and compared with the previously reported FeII-containing compound (1).	Nickel arsenide (NiAs)	72-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-113
28053596-6	2017	METHODS: We have attempted to identify the anti-proliferation of celecoxib, a selective COX-2 inhibitor, and the combination of celecoxib and cisplatin in MG-63 cells, and to explore the potential molecular mechanisms involved.	Celecoxib	65-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-93
28123844-6	2017	Further mechanism studies showed that the combined treatment of melatonin and cisplatin enhanced the cleavage of caspase-3, caspase-9 and poly-(ADP-ribose) polymerase (PARP), decreased the expression of Bcl-2 and p-IKKalpha/beta, suppressed the nuclear translocation of NF-kappaB p50/p65 proteins, and abrogated the binding of p65 to COX-2 promoter, thereby inhibiting COX-2 expression.	Melatonin	64-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	334-339
28123844-6	2017	Further mechanism studies showed that the combined treatment of melatonin and cisplatin enhanced the cleavage of caspase-3, caspase-9 and poly-(ADP-ribose) polymerase (PARP), decreased the expression of Bcl-2 and p-IKKalpha/beta, suppressed the nuclear translocation of NF-kappaB p50/p65 proteins, and abrogated the binding of p65 to COX-2 promoter, thereby inhibiting COX-2 expression.	Melatonin	64-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	369-374
28123844-6	2017	Further mechanism studies showed that the combined treatment of melatonin and cisplatin enhanced the cleavage of caspase-3, caspase-9 and poly-(ADP-ribose) polymerase (PARP), decreased the expression of Bcl-2 and p-IKKalpha/beta, suppressed the nuclear translocation of NF-kappaB p50/p65 proteins, and abrogated the binding of p65 to COX-2 promoter, thereby inhibiting COX-2 expression.	Cisplatin	78-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	334-339
28123844-6	2017	Further mechanism studies showed that the combined treatment of melatonin and cisplatin enhanced the cleavage of caspase-3, caspase-9 and poly-(ADP-ribose) polymerase (PARP), decreased the expression of Bcl-2 and p-IKKalpha/beta, suppressed the nuclear translocation of NF-kappaB p50/p65 proteins, and abrogated the binding of p65 to COX-2 promoter, thereby inhibiting COX-2 expression.	Cisplatin	78-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	369-374
28123844-9	2017	Collectively, our results demonstrated that melatonin sensitizes the cisplatin-mediated growth suppression of cells via the inactivation of NF-kappaB/COX-2 and AP-2beta/hTERT signaling in hepatocellular carcinoma cells.	Melatonin	44-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	150-155
28123844-9	2017	Collectively, our results demonstrated that melatonin sensitizes the cisplatin-mediated growth suppression of cells via the inactivation of NF-kappaB/COX-2 and AP-2beta/hTERT signaling in hepatocellular carcinoma cells.	Cisplatin	69-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	150-155
28356021-0	2017	Novel Thiourea Derivatives Bearing Sulfonamide Moiety as Anticancer Agents Through COX-2 Inhibition.	Thiourea	6-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
28356021-0	2017	Novel Thiourea Derivatives Bearing Sulfonamide Moiety as Anticancer Agents Through COX-2 Inhibition.	Sulfonamides	35-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
28618989-6	2017	And as part of an in silico screening the leading compounds were docked into the tyrosine sites of COX-1/COX-2 enzymes (PDB code: 1DIY and 1CVU).	Tyrosine	81-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-110
28618989-9	2017	CONCLUSION: The tendency to occurrence of anti-inflammatory properties of synthesized derivatives of quinolizidine alkaloid (-)-cytisine can be explained on the basis of molecular docking results, which assume the possibility of interaction of more potent compounds with key amino acids of COX-1/COX-2 active sites.	UNII-W676AVD2TS	101-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	296-301
28618989-9	2017	CONCLUSION: The tendency to occurrence of anti-inflammatory properties of synthesized derivatives of quinolizidine alkaloid (-)-cytisine can be explained on the basis of molecular docking results, which assume the possibility of interaction of more potent compounds with key amino acids of COX-1/COX-2 active sites.	cytisine	124-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	296-301
27816443-12	2017	In macrophages, lucidone-activated NF-kappaB-mediated inflammation (COX-2/iNOS/NO) and VEGF, which may contribute to the growth of keratinocytes/fibroblasts and endothelial cells.	lucidone	16-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-73
29386985-1	2017	Co(II) electronic configuration allows its use as a spectroscopic probe in UV-Vis experiments to characterize the metal coordination sphere that is an essential component of the functional structure of zinc-binding proteins and to evaluate the metal ion affinities of these proteins.	Metals	114-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
29386985-1	2017	Co(II) electronic configuration allows its use as a spectroscopic probe in UV-Vis experiments to characterize the metal coordination sphere that is an essential component of the functional structure of zinc-binding proteins and to evaluate the metal ion affinities of these proteins.	Metals	244-249	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
29386985-2	2017	Here, exploiting the capability of the prokaryotic zinc finger to use different combinations of residues to properly coordinate the structural metal ion, we provide the UV-Vis characterization of Co(II) addition to Ros87 and its mutant Ros87_C27D which bears an unusual CysAspHis2 coordination sphere.	Metals	143-148	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	196-202
27842798-2	2017	In COX-1 and COX-2, the active sites are composed of the same group of amino acids with the exception of the only one residue in position 523, in COX-1 is an isoleucine, while in COX-2 is a valine.	Isoleucine	158-168	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
27842798-2	2017	In COX-1 and COX-2, the active sites are composed of the same group of amino acids with the exception of the only one residue in position 523, in COX-1 is an isoleucine, while in COX-2 is a valine.	Isoleucine	158-168	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	179-184
27842798-2	2017	In COX-1 and COX-2, the active sites are composed of the same group of amino acids with the exception of the only one residue in position 523, in COX-1 is an isoleucine, while in COX-2 is a valine.	Valine	190-196	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
28854439-2	2017	However, the specific prostaglandin contributing to COX-2 effect on IS-induced MC proliferation remained unknown.	Prostaglandins	22-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-57
28828990-2	2017	The discovery of cyclooxygenase-2 (COX- 2) improved the pharmacology of nonsteroidal anti-inflammatory drugs (NSAID) giving a clear mechanism for prostaglandin regulation in vivo and providing a new target for the development of COX-2-selective drugs without gastrointestinal side-effects.	Prostaglandins	146-159	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	229-234
29332887-1	2017	15 K is 1,2, 3-triazolyl ester of ketorolac, an old pain-killer, that blocks PAK1 by its R-form and inhibits COX-2 by its S-form.	1,2, 3-triazolyl ester	8-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-114
29332887-1	2017	15 K is 1,2, 3-triazolyl ester of ketorolac, an old pain-killer, that blocks PAK1 by its R-form and inhibits COX-2 by its S-form.	Ketorolac	34-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-114
27863298-10	2017	We found that butein significantly inhibited the IL-1beta-induced production of NO and PGE2, expression of COX-2, iNOS, TNF-alpha, IL-6 and MMP-13, degradation of COL-2 and SOX-9 at mRNA and protein levels as well as MMP-1, MMP-3, ADAMTS-4 and ADAMTS-5 gene expression.	butein	14-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-112
27741434-4	2017	Short pretreatment of M-CSF macrophages with autologous postprandial TRLs induced the down-regulation of HCA2 gene and up-regulation of genes encoding COX1 and COX2 enzymes in a fatty acid-dependent manner.	Fatty Acids	178-188	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	160-164
28007462-2	2017	We previously reported that in colon cancer cells, celecoxib, a COX-2-selective NSAID, inhibited the canonical Wnt/beta-catenin signaling pathway.	Celecoxib	51-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-69
28592114-11	2017	Additionally, SZC014 treatment suppressed the levels of Akt, phosphorylated-Akt (p-Akt), COX-2, p-p65 in the cytoplasmic and p65 in nuclear.	2-(pyrrolidine-1-yl)methyl-3-oxoolean-12-en-28-oic acid	14-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-94
27689692-5	2017	These results demonstrate that Schizandrin B can regulate the function of decreasing intracellular SOD"s activity and increasing the expression level of MDA in HaCaT cells result from the guidance of UVB, and it markedly reduced the production of inflammatory factors such as Cox-2, IL-6 or IL-18, decreased the expression level of MMP-1, and interdicted degradation process of collagens in UVB-radiated cells.	schizandrin B	31-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	276-281
28119811-6	2017	Molecular docking studies on the most active compound 3f revealed a binding mode similar to that of celecoxib in the active site of the COX-2 enzyme.	Celecoxib	100-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	136-141
28826532-5	2017	Emerging data from multiple labs also show that monoacylglycerols (including 2-AG), COX-2 metabolites, and fatty acid esters of hydroxyl fatty acids are interconnected with these lipoamines at both the biosynthetic and metabolic levels.	lipoamines	179-189	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-89
28270082-2	2017	OBJECTIVE: In this research, the actions of a synthetic beta lactam-structured Cox-2 inhibitor with 4-(4- (Methylsulfonyl) phenyl)-1-pentyl-3-phenoxyazetidin-2-one on cellular viability of cancerous lymphoblast obtained from patients with acute lymphocytic leukemia (ALL) and normal lymphocytes obtained from healthy donors were compared.	beta-Lactams	56-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-84
28270082-2	2017	OBJECTIVE: In this research, the actions of a synthetic beta lactam-structured Cox-2 inhibitor with 4-(4- (Methylsulfonyl) phenyl)-1-pentyl-3-phenoxyazetidin-2-one on cellular viability of cancerous lymphoblast obtained from patients with acute lymphocytic leukemia (ALL) and normal lymphocytes obtained from healthy donors were compared.	4-(4-(methylsulfonyl)phenyl)-1-pentyl-3-phenoxyazetidin-2-one	100-163	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-84
27354402-4	2017	In this study, we have hypothesized that COX-2 specific inhibitors such as Valdecoxib (VLX), being highly hydrophobic, may alter biophysical properties of cellular lipids.	valdecoxib	75-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-46
27354402-4	2017	In this study, we have hypothesized that COX-2 specific inhibitors such as Valdecoxib (VLX), being highly hydrophobic, may alter biophysical properties of cellular lipids.	valdecoxib	87-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-46
28458341-2	2017	In some animal models of brain disease, the genetic disruption and chemical inhibition of cyclooxygenase (COX)-2 resulted in the reduction of PGE2 and amelioration of symptoms, and it had been thought that PGE2 produced by COX-2 may be involved in the progression of injuries.	Dinoprostone	142-146	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-112
28458341-2	2017	In some animal models of brain disease, the genetic disruption and chemical inhibition of cyclooxygenase (COX)-2 resulted in the reduction of PGE2 and amelioration of symptoms, and it had been thought that PGE2 produced by COX-2 may be involved in the progression of injuries.	Dinoprostone	206-210	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-112
28458341-2	2017	In some animal models of brain disease, the genetic disruption and chemical inhibition of cyclooxygenase (COX)-2 resulted in the reduction of PGE2 and amelioration of symptoms, and it had been thought that PGE2 produced by COX-2 may be involved in the progression of injuries.	Dinoprostone	206-210	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	223-228
28458341-3	2017	However, COX-2 produces not only PGE2, but also some other prostanoids, and thus the protective effects of COX-2 inhibition, as well as severe side effects, may be caused by the inhibition of prostanoids other than PGE2.	Dinoprostone	33-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	9-14
28458341-3	2017	However, COX-2 produces not only PGE2, but also some other prostanoids, and thus the protective effects of COX-2 inhibition, as well as severe side effects, may be caused by the inhibition of prostanoids other than PGE2.	Prostaglandins	59-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	9-14
28458341-3	2017	However, COX-2 produces not only PGE2, but also some other prostanoids, and thus the protective effects of COX-2 inhibition, as well as severe side effects, may be caused by the inhibition of prostanoids other than PGE2.	Prostaglandins	192-203	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	9-14
28458341-3	2017	However, COX-2 produces not only PGE2, but also some other prostanoids, and thus the protective effects of COX-2 inhibition, as well as severe side effects, may be caused by the inhibition of prostanoids other than PGE2.	Prostaglandins	192-203	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-112
29376073-5	2017	Molecular mechanisms or pathways involving autophagy, hypoxia, COX-2, NF-kappaB activity, and stemness are known to be induced by BQ ingredients and are very closely related to the carcinogenesis of cancers of oral and pharynx.	bulaquine	130-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-68
29250535-7	2017	The expressions of HPV16 E6 and COX-2 in paraffin-embedded tissues of the invasive ductal breast cancer were detected by qPCR and IHC.	Paraffin	41-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-37
29250535-12	2017	Inhibition of COX-2 by siCOX-2 or Celecoxib attenuated the proliferation of breast cancer cells with HPV16 E6 expression; and the upregulation of COX-2 could be suppressed by the inhibition of NF-kappaB activity.	sicox	23-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
29250535-12	2017	Inhibition of COX-2 by siCOX-2 or Celecoxib attenuated the proliferation of breast cancer cells with HPV16 E6 expression; and the upregulation of COX-2 could be suppressed by the inhibition of NF-kappaB activity.	Celecoxib	34-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
27842798-2	2017	In COX-1 and COX-2, the active sites are composed of the same group of amino acids with the exception of the only one residue in position 523, in COX-1 is an isoleucine, while in COX-2 is a valine.	Valine	190-196	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	179-184
27842798-3	2017	Here, we presented a series of isothiazolopyridine/benzisothiazole derivatives substituted differently into an isothiazole ring, which were synthesized and investigated for their potencies to inhibit COX-1 and COX-2 enzymes by colorimetric inhibitor screening assay.	isothiazolopyridine	31-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	210-215
27842798-3	2017	Here, we presented a series of isothiazolopyridine/benzisothiazole derivatives substituted differently into an isothiazole ring, which were synthesized and investigated for their potencies to inhibit COX-1 and COX-2 enzymes by colorimetric inhibitor screening assay.	benzisothiazole	51-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	210-215
27842798-3	2017	Here, we presented a series of isothiazolopyridine/benzisothiazole derivatives substituted differently into an isothiazole ring, which were synthesized and investigated for their potencies to inhibit COX-1 and COX-2 enzymes by colorimetric inhibitor screening assay.	Isothiazole	55-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	210-215
28039239-9	2017	For AOM used alone, morphine consumption reduction was greatest with alpha-2 agonists, NSAIDs, and COX-2 inhibitors.	Morphine	20-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-104
27761963-1	2017	We previously reported that celecoxib, a selective COX-2 inhibitor, strongly inhibited human colon cancer cell proliferation by suppressing the Wnt/beta-catenin signaling pathway.	Celecoxib	28-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-56
28210513-0	2017	Seizure following the Use of the COX-2 Inhibitor Etoricoxib.	Etoricoxib	49-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-38
28210513-4	2017	Neuroimaging and blood samples studies did not evidence alterations, but a careful pharmacological history revealed that the patient had taken the COX-2 inhibitor etoricoxib to treat lumbago few days before the onset of clinical symptoms.	Etoricoxib	163-173	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-152
27528055-2	2017	We have evaluated the most promising compounds for their efficiency to a) intercept and scavenge free radicals, b) inhibit the metal ion (Cu2+)- induced LDL oxidation c) act intracellularly as antioxidants in THP-1 monocytes from a leukemic patient and d) inhibit the pro-inflammatory enzymes cyclooxygenase-1 (COX-1) and -2 (COX-2) in vitro.	cupric ion	138-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	326-331
28571535-2	2017	After the identification of a second isoform of COX, the pharmaceutical research focused on developing COX-2- selective drugs (COXIBs) considered as second generation NSAIDs that would retain the anti-inflammatory and analgesic activities of traditional NSAID without blunting the gastrointestinal cytoprotection sustained by COX1-derived products such as PGE2.	Dinoprostone	356-360	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-108
27237330-1	2017	Isoindole derivatives constitute an important class of biologically active heterocyclic compounds and continue to attract considerable attention due to their diverse pharmacological profile such as, antimicrobial, anthelmintic, insecticidal, cyclooxygenase isoenzyme (COX-2) and thrombin inhibition with special emphasis on anticancer activity.	Isoindoles	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	268-273
27405497-9	2017	Clinical data on aspirin, an irreversible inhibitor of both COX-1 and COX-2, are mainly experimental and hypothetical at this stage, but may be promising in depressed patients with concomitant inflammatory conditions.	Aspirin	17-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-75
27128654-6	2017	Curcumin and its analogues significantly inhibited VEGF-A synthesis and secretion in both cell lines in association with loss of HIF-1alpha, COX-2, and p-STAT-3 expression.	Curcumin	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	141-146
27852824-2	2016	VEGF-C and VEGF-D were thought to exhibit similar bioactivities, yet recent studies indicated distinct signaling mechanisms (e.g. tumor-derived VEGF-C promoted expression of the prostaglandin biosynthetic enzyme COX-2 in lymphatics, a response thought to facilitate metastasis via the lymphatic vasculature, whereas VEGF-D did not).	Prostaglandins	178-191	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	212-217
28785285-4	2017	We show that MAPC suppress the secretion of tumor necrosis factor alpha (TNF-alpha) by inflammatory macrophages partially through a cyclooxygenase 2- (COX-2-) dependent mechanism.	mapc	13-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-156
28785285-5	2017	In turn, we demonstrate that inflammatory macrophages trigger the immunomodulatory properties of MAPC, including an increased expression of immunomodulatory mediators (e.g., inducible nitric oxide synthase (iNOS) and COX-2), chemokines, and chemokine receptors.	mapc	97-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	217-222
28884717-7	2017	A drug of choice in case of intensive pain and marked nociceptive component are highly effective and safe nonsteroidal anti-inflammatory drugs, in particular etoricoxib (Arcoxia), a selective COX-2 inhibitor.	Etoricoxib	158-168	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	192-197
28884717-7	2017	A drug of choice in case of intensive pain and marked nociceptive component are highly effective and safe nonsteroidal anti-inflammatory drugs, in particular etoricoxib (Arcoxia), a selective COX-2 inhibitor.	Etoricoxib	170-177	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	192-197
27874901-0	2016	The assembly of thiophene-based bis-pyridyl-bis-amide CoII coordination polymers and their polypyrrole-functionalized hybrid materials for boosting their photocatalytic performances.	Polymers	72-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-58
27818125-7	2016	In the present study, we examined the effect of aflatoxin B1 on COX-2 by using the placental cell model JEG-3 and the respective signaling pathway.	Aflatoxin B1	48-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-69
27824617-7	2016	Moreover, knockdown of COX-2 by siRNA Oligonucleotides or abrogating activity of COX-2 by specific inhibitors resulted in impairment of VM formation.	Oligonucleotides	38-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-28
27841393-0	2016	A CoII complex for 19F MRI-based detection of reactive oxygen species.	Reactive Oxygen Species	46-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	2-6
27841393-2	2016	Upon oxidation with H2O2, the complex converts from paramagnetic high spin CoII to diamagnetic low spin CoIII resulting in a chemical shift change and enhancement in 19F NMR signal.	Hydrogen Peroxide	20-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-79
27835884-0	2016	Combination of COX-2 expression and PIK3CA mutation as prognostic and predictive markers for celecoxib treatment in breast cancer.	Celecoxib	93-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-20
27835884-3	2016	Based on an interesting study of aspirin efficacy in colorectal cancer, we hypothesized that celecoxib antitumoral activity may be restricted to PIK3CA mutated BC.COX-2 mRNA expression was analyzed in 446 BC samples and in 61 BC patient-derived xenografts (PDX) using quantitative RT-PCR.	Celecoxib	93-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	163-168
27835884-5	2016	The antitumoral activity of celecoxib was tested in two triple-negative (TN) PDX with a PIK3CA wild-type (wt) or mutated genotype.COX-2 mRNA was overexpressed in 2% of BC and significantly associated with TN subtype.	Celecoxib	28-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	130-135
27835884-9	2016	Celecoxib antitumoral activity involved S6 ribosomal protein and AKT phosphorylation.Low expression of COX-2 has a significant negative impact on the MFS/DFS of BC patients.	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-108
27874901-0	2016	The assembly of thiophene-based bis-pyridyl-bis-amide CoII coordination polymers and their polypyrrole-functionalized hybrid materials for boosting their photocatalytic performances.	polypyrrole	91-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-58
27882369-5	2016	The polymerization results show that the cis-1,4 selectivity is influenced by the steric hindrance, increasing with the bulkiness of the substituent groups (CoX2-iPr &gt; CoX2-Me &gt; CoX2-H) at the 3,5-positions of the pyrazole moiety, together with a slight decrease in activity.	pyrazole	220-228	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	157-161
27835591-3	2016	The anti-inflammatory COX2 inhibitor celecoxib has been utilized as anti-tumour drug due to its anti-proliferative activity.	Celecoxib	37-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-26
27882369-5	2016	The polymerization results show that the cis-1,4 selectivity is influenced by the steric hindrance, increasing with the bulkiness of the substituent groups (CoX2-iPr &gt; CoX2-Me &gt; CoX2-H) at the 3,5-positions of the pyrazole moiety, together with a slight decrease in activity.	pyrazole	220-228	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	171-175
27835591-8	2016	Finally, it suppressed colony formation of CD34+ cells from CML patients, while sparing most CD34+ progenitors from healthy donors, and induced apoptosis of primary Ph+ ALL cells.Together, these findings indicate that celecoxib may serve as a COX2-independent lead compound to simultaneously target the mTOR and beta-catenin pathways, key players in the resistance of CML stem cells to TKIs.	Celecoxib	218-227	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	243-247
27882369-5	2016	The polymerization results show that the cis-1,4 selectivity is influenced by the steric hindrance, increasing with the bulkiness of the substituent groups (CoX2-iPr &gt; CoX2-Me &gt; CoX2-H) at the 3,5-positions of the pyrazole moiety, together with a slight decrease in activity.	pyrazole	220-228	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	171-175
27698065-13	2016	The enhanced intracellular cAMP in FSS conditions was blocked by COX1/COX2 (cyclooxygenase) inhibitors, suggesting that the increase in prostaglandin E2 production could activate the cAMP/protein kinase A pathway in an autocrine/paracrine fashion.	Cyclic AMP	27-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-74
27934436-2	2016	Upon oxidation and deprotonation in the presence of the acetate salts of CoII and DyIII, the vdpyCH2OH radical is able to self-assemble [(vdpyCH2O)2Co2Dy2ac8] (Hac = HO2CCH3), a 2p-3d-4f cluster displaying single-molecule-magnet properties.	Acetates	56-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-77
27934436-2	2016	Upon oxidation and deprotonation in the presence of the acetate salts of CoII and DyIII, the vdpyCH2OH radical is able to self-assemble [(vdpyCH2O)2Co2Dy2ac8] (Hac = HO2CCH3), a 2p-3d-4f cluster displaying single-molecule-magnet properties.	ho2cch3	166-173	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-77
27601438-0	2016	Ibuprofen arginate retains eNOS substrate activity and reverses endothelial dysfunction: implications for the COX-2/ADMA axis.	Ibuprofen	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-115
27601438-0	2016	Ibuprofen arginate retains eNOS substrate activity and reverses endothelial dysfunction: implications for the COX-2/ADMA axis.	L-argininate	10-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-115
27601438-1	2016	Nonsteroidal antiinflammatory drugs, including ibuprofen, are among the most commonly used medications and produce their antiinflammatory effects by blocking cyclooxygenase (COX)-2.	Ibuprofen	47-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	158-180
27601438-2	2016	Their use is associated with increased risk of heart attacks caused by blocking COX-2 in the vasculature and/or kidney, with our recent work implicating the endogenous NOS inhibitor asymmetric dimethylarginine (ADMA), a cardiotoxic hormone whose effects can be prevented by l-arginine.	dimethylarginine	193-209	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-85
27601438-2	2016	Their use is associated with increased risk of heart attacks caused by blocking COX-2 in the vasculature and/or kidney, with our recent work implicating the endogenous NOS inhibitor asymmetric dimethylarginine (ADMA), a cardiotoxic hormone whose effects can be prevented by l-arginine.	N,N-dimethylarginine	211-215	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-85
27601438-4	2016	Here we investigated the idea that ibuprofen arginate can act to simultaneously inhibit COX-2 and preserve the NO pathway.	ibuprofen arginine	35-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-93
27601438-5	2016	Ibuprofen arginate functioned similarly to ibuprofen sodium for inhibition of mouse/human COX-2, but only ibuprofen arginate served as a substrate for NOS.	ibuprofen arginine	0-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-95
27601438-5	2016	Ibuprofen arginate functioned similarly to ibuprofen sodium for inhibition of mouse/human COX-2, but only ibuprofen arginate served as a substrate for NOS.	Ibuprofen	43-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-95
27601438-7	2016	These observations show that ibuprofen arginate provides, in one preparation, a COX-2 inhibitor and NOS substrate that could act to negate the harmful cardiovascular consequences mediated by blocking renal COX-2 and increased ADMA.	ibuprofen arginine	29-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-85
27601438-7	2016	These observations show that ibuprofen arginate provides, in one preparation, a COX-2 inhibitor and NOS substrate that could act to negate the harmful cardiovascular consequences mediated by blocking renal COX-2 and increased ADMA.	ibuprofen arginine	29-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	206-211
27601438-10	2016	Ibuprofen arginate retains eNOS substrate activity and reverses endothelial dysfunction: implications for the COX-2/ADMA axis.	ibuprofen arginine	0-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-115
27698065-13	2016	The enhanced intracellular cAMP in FSS conditions was blocked by COX1/COX2 (cyclooxygenase) inhibitors, suggesting that the increase in prostaglandin E2 production could activate the cAMP/protein kinase A pathway in an autocrine/paracrine fashion.	Dinoprostone	136-152	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-74
27192488-0	2016	Resistance to 3-HTMC-Induced Apoptosis Through Activation of PI3K/Akt, MEK/ERK, and p38/COX-2/PGE2 Pathways in Human HT-29 and HCT116 Colorectal Cancer Cells.	3-hydroxy-3',4,4',5'-tetramethoxychalcone	14-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-93
28053929-2	2016	PGE2 and PGI2 are two important prostaglandins synthesised by COX-2 enzymes, involved in migraine pain signals.	Dinoprostone	0-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
28053929-2	2016	PGE2 and PGI2 are two important prostaglandins synthesised by COX-2 enzymes, involved in migraine pain signals.	Epoprostenol	9-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
28053929-2	2016	PGE2 and PGI2 are two important prostaglandins synthesised by COX-2 enzymes, involved in migraine pain signals.	Prostaglandins	32-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
27515563-5	2016	Here, we showed that EGCG inhibits COX-2 mRNA/protein expression or prostaglandin E2 (PGE2 ) production via up-regulating microRNA hsa-miR-199a-3p expression in interleukin (IL)-1beta-stimulated human OA chondrocytes.	epigallocatechin gallate	21-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40
26610257-4	2016	Based on phenols previously identified, and taking as reference the crystallographic structures of COX-1 and COX-2 in complex with the commercial drug Celecoxib, a molecular docking procedure was devised to adjust 123 phenolic molecular models at the enzyme-binding sites.	Celecoxib	151-160	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-114
27816506-2	2016	The active constituents of Rosa spp., such as flavonoids, triterpenoids, and phytosterols, could act on different targets in the NF-kappaB signalling pathway, inhibit pro-inflammatory enzymes (e.g. MMPs and COX-2), lower the production of inflammatory cytokines and chemokines (e.g. TNF-alpha, IL-1beta, IL-6, CCL5), and reduce oxidative stress, which in turn suppress inflammatory processes.	Flavonoids	46-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	207-212
27576781-1	2016	WHAT IS KNOWN AND OBJECTIVE: Etoricoxib is a non-steroidal anti-inflammatory drug (NSAID) that inhibits the inducible cyclooxygenase (COX-2) with a good safety profile.	Etoricoxib	29-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-139
27072288-6	2016	In addition, molecular docking studies were performed for compounds 13d, 13f, 13k and 13o inside COX-2 active site which showed acceptable binding interactions (affinity in kcal/mol -2.1774, -6.9498) in comparison with celecoxib (affinity in kcal/mol -6.5330).	Celecoxib	219-228	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
27515563-6	2016	This negative co-regulation of hsa-miR-199a-3p and COX-2 by EGCG was confirmed by transfection of OA chondrocytes with anti-miR-199a-3p.	epigallocatechin gallate	60-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-56
27515563-7	2016	Transfection of OA chondrocytes with anti-miR-199a-3p significantly enhanced COX-2 expression and PGE2 production (P &lt; 0.001), while EGCG treatment significantly inhibited anti-miR-199a-3p transfection-induced COX-2 expression or PGE2 production in a dose-dependent manner.	epigallocatechin gallate	136-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	213-218
27515563-9	2016	EGCG treatment consistently up-regulated the IL-1beta-decreased hsa-miR-199a-3p expression (P &lt; 0.05) and significantly inhibited the IL-1beta-induced COX-2 expression/PGE2 production (P &lt; 0.05) in OA chondrocytes transfected with anti-hsa-miR-199a-3p.	epigallocatechin gallate	0-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	154-159
27515563-10	2016	Taken together, these results clearly indicate that EGCG inhibits COX-2 expression/PGE2 production via up-regulation of hsa-miR-199a-3p expression.	epigallocatechin gallate	52-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-71
27816506-2	2016	The active constituents of Rosa spp., such as flavonoids, triterpenoids, and phytosterols, could act on different targets in the NF-kappaB signalling pathway, inhibit pro-inflammatory enzymes (e.g. MMPs and COX-2), lower the production of inflammatory cytokines and chemokines (e.g. TNF-alpha, IL-1beta, IL-6, CCL5), and reduce oxidative stress, which in turn suppress inflammatory processes.	Phytosterols	77-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	207-212
27775741-0	2016	Spin-state diversity in a series of Co(ii) PNP pincer bromide complexes.	pincer bromide	47-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-42
27775741-1	2016	We describe the structural and electronic impacts of modifying the bridging atom in a family of Co(ii) pincer complexes with the formula Co(t-Bu)2PEPyEP(t-Bu)2Br2 (Py = pyridine, E = CH2, NH, and O for compounds 1-3, respectively).	co(t-bu)2pepyep(t-bu)2br2	137-162	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-102
27775741-1	2016	We describe the structural and electronic impacts of modifying the bridging atom in a family of Co(ii) pincer complexes with the formula Co(t-Bu)2PEPyEP(t-Bu)2Br2 (Py = pyridine, E = CH2, NH, and O for compounds 1-3, respectively).	pyridine	148-150	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-102
27775741-1	2016	We describe the structural and electronic impacts of modifying the bridging atom in a family of Co(ii) pincer complexes with the formula Co(t-Bu)2PEPyEP(t-Bu)2Br2 (Py = pyridine, E = CH2, NH, and O for compounds 1-3, respectively).	pyridine	169-177	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-102
27775741-2	2016	Structural characterization by single crystal X-ray diffraction indicates that compounds 1 and 3 are 5-coordinate complexes with both bromides bound to the Co(ii) ion, while compound 2 is square planar with one bromide in the outer coordination sphere.	Bromides	134-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	156-162
27775741-2	2016	Structural characterization by single crystal X-ray diffraction indicates that compounds 1 and 3 are 5-coordinate complexes with both bromides bound to the Co(ii) ion, while compound 2 is square planar with one bromide in the outer coordination sphere.	Bromides	134-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	156-162
27766836-5	2016	Here, we synthesize well-defined Co(II) ions on a silica surface using a metal siloxide precursor followed by thermal treatment under vacuum at 500  C. We show that these isolated Co(II) sites are catalysts for a number of hydrocarbon conversion reactions, such as the dehydrogenation of propane, the hydrogenation of propene, and the trimerization of terminal alkynes.	Silicon Dioxide	50-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-39
27994517-5	2016	COX-2 in TAMs induces MMP-9 expression and promotes epithelial-mesenchymal transition (EMT) in breast cancer cells.	tams	9-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
27994517-6	2016	In addition, COX-2/PGE2 induces IL-6 release in macrophages.	Dinoprostone	19-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
27662097-2	2016	The crystal structure of the host alpha-LiZnBO3 , which is both disordered and distorted with respect to Li and Zn occupancies and coordination geometries, is largely retained in the derivatives, which gives rise to unique colors (blue for CoII , magenta for NiII , violet for CuII ) that could be of significance for the development of new, inexpensive, and environmentally friendly pigment materials, particularly in the case of the blue pigments.	alpha-liznbo3	34-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	240-244
27662097-2	2016	The crystal structure of the host alpha-LiZnBO3 , which is both disordered and distorted with respect to Li and Zn occupancies and coordination geometries, is largely retained in the derivatives, which gives rise to unique colors (blue for CoII , magenta for NiII , violet for CuII ) that could be of significance for the development of new, inexpensive, and environmentally friendly pigment materials, particularly in the case of the blue pigments.	Zinc	42-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	240-244
27887602-1	2016	It has been suggested that aspirin may be of benefit in treating sepsis and ARDS in view of its ability to block cyclo-oxygenase-1 (COX-1) and COX-2 activities; inhibit nuclear factor kappa B (NF-kappaB); enhance the production of endothelial nitric oxide (eNO) and lipoxin A4 (LXA4).	Aspirin	27-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	143-148
27934305-1	2016	Two high-spin Fe(II) and Co(II) complexes of 1,4,7,10-tetraazacyclododecane (CYCLEN) appended with four 2-amino-6-picolyl groups, denoted as [Fe(TAPC)]2+ and [Co(TAPC)]2+, are reported.	cyclen	45-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-31
27934305-1	2016	Two high-spin Fe(II) and Co(II) complexes of 1,4,7,10-tetraazacyclododecane (CYCLEN) appended with four 2-amino-6-picolyl groups, denoted as [Fe(TAPC)]2+ and [Co(TAPC)]2+, are reported.	tapc)	145-150	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-31
27934305-1	2016	Two high-spin Fe(II) and Co(II) complexes of 1,4,7,10-tetraazacyclododecane (CYCLEN) appended with four 2-amino-6-picolyl groups, denoted as [Fe(TAPC)]2+ and [Co(TAPC)]2+, are reported.	co(tapc)	159-167	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-31
27980840-2	2016	The CoII cation is octa-hedrally coordinated by two terminal N-bonding thio-cyanate anions, two methanol mol-ecules and two 3,5-di-methyl-pyridine ligands into a discrete complex.	thiocyanate	71-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-8
27980840-2	2016	The CoII cation is octa-hedrally coordinated by two terminal N-bonding thio-cyanate anions, two methanol mol-ecules and two 3,5-di-methyl-pyridine ligands into a discrete complex.	Methanol	96-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-8
27980840-2	2016	The CoII cation is octa-hedrally coordinated by two terminal N-bonding thio-cyanate anions, two methanol mol-ecules and two 3,5-di-methyl-pyridine ligands into a discrete complex.	3,5-dimethylpyridine	124-146	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-8
27766836-5	2016	Here, we synthesize well-defined Co(II) ions on a silica surface using a metal siloxide precursor followed by thermal treatment under vacuum at 500  C. We show that these isolated Co(II) sites are catalysts for a number of hydrocarbon conversion reactions, such as the dehydrogenation of propane, the hydrogenation of propene, and the trimerization of terminal alkynes.	Silicon Dioxide	50-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	180-186
27766836-5	2016	Here, we synthesize well-defined Co(II) ions on a silica surface using a metal siloxide precursor followed by thermal treatment under vacuum at 500  C. We show that these isolated Co(II) sites are catalysts for a number of hydrocarbon conversion reactions, such as the dehydrogenation of propane, the hydrogenation of propene, and the trimerization of terminal alkynes.	metal siloxide	73-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-39
27766836-5	2016	Here, we synthesize well-defined Co(II) ions on a silica surface using a metal siloxide precursor followed by thermal treatment under vacuum at 500  C. We show that these isolated Co(II) sites are catalysts for a number of hydrocarbon conversion reactions, such as the dehydrogenation of propane, the hydrogenation of propene, and the trimerization of terminal alkynes.	metal siloxide	73-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	180-186
27766836-5	2016	Here, we synthesize well-defined Co(II) ions on a silica surface using a metal siloxide precursor followed by thermal treatment under vacuum at 500  C. We show that these isolated Co(II) sites are catalysts for a number of hydrocarbon conversion reactions, such as the dehydrogenation of propane, the hydrogenation of propene, and the trimerization of terminal alkynes.	Hydrocarbons	223-234	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-39
27766836-5	2016	Here, we synthesize well-defined Co(II) ions on a silica surface using a metal siloxide precursor followed by thermal treatment under vacuum at 500  C. We show that these isolated Co(II) sites are catalysts for a number of hydrocarbon conversion reactions, such as the dehydrogenation of propane, the hydrogenation of propene, and the trimerization of terminal alkynes.	Hydrocarbons	223-234	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	180-186
27766836-5	2016	Here, we synthesize well-defined Co(II) ions on a silica surface using a metal siloxide precursor followed by thermal treatment under vacuum at 500  C. We show that these isolated Co(II) sites are catalysts for a number of hydrocarbon conversion reactions, such as the dehydrogenation of propane, the hydrogenation of propene, and the trimerization of terminal alkynes.	Propane	288-295	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-39
27766836-5	2016	Here, we synthesize well-defined Co(II) ions on a silica surface using a metal siloxide precursor followed by thermal treatment under vacuum at 500  C. We show that these isolated Co(II) sites are catalysts for a number of hydrocarbon conversion reactions, such as the dehydrogenation of propane, the hydrogenation of propene, and the trimerization of terminal alkynes.	Propane	288-295	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	180-186
27766836-5	2016	Here, we synthesize well-defined Co(II) ions on a silica surface using a metal siloxide precursor followed by thermal treatment under vacuum at 500  C. We show that these isolated Co(II) sites are catalysts for a number of hydrocarbon conversion reactions, such as the dehydrogenation of propane, the hydrogenation of propene, and the trimerization of terminal alkynes.	propylene	318-325	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-39
27766836-5	2016	Here, we synthesize well-defined Co(II) ions on a silica surface using a metal siloxide precursor followed by thermal treatment under vacuum at 500  C. We show that these isolated Co(II) sites are catalysts for a number of hydrocarbon conversion reactions, such as the dehydrogenation of propane, the hydrogenation of propene, and the trimerization of terminal alkynes.	propylene	318-325	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	180-186
27766836-5	2016	Here, we synthesize well-defined Co(II) ions on a silica surface using a metal siloxide precursor followed by thermal treatment under vacuum at 500  C. We show that these isolated Co(II) sites are catalysts for a number of hydrocarbon conversion reactions, such as the dehydrogenation of propane, the hydrogenation of propene, and the trimerization of terminal alkynes.	Alkynes	361-368	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-39
27766836-5	2016	Here, we synthesize well-defined Co(II) ions on a silica surface using a metal siloxide precursor followed by thermal treatment under vacuum at 500  C. We show that these isolated Co(II) sites are catalysts for a number of hydrocarbon conversion reactions, such as the dehydrogenation of propane, the hydrogenation of propene, and the trimerization of terminal alkynes.	Alkynes	361-368	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	180-186
27541263-6	2016	The inhibitory activity of COX-2 and 5-LOX were tested for 5a-h. Three compounds, 5c, 5d and 5f showed excellent COX-2 inhibitory activity with IC50 ranging from 0.98 to 1.23 muM compared to the reference celecoxib (1.54 muM).	Celecoxib	205-214	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-32
27683033-5	2016	Molecular and cellular study demonstrated that Asp-UA significantly down-regulated the expression of cell adhesion and invasion molecules including integrin alpha6beta1, CD44 ,MMP-2, MMP-9, COX-2, EGFR and ERK proteins, and up-regulated the epithelial markers "E-cadherin" and "beta-catenin", and PTEN proteins.	asp-ua	47-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	190-195
27677075-7	2016	This resulted in MS-444-mediated inhibition of COX-2 and other ARE-mRNA expression levels.	5,8-dihydroxy-3-methyl-4-(9H)-naphtho(2,3-c)furanone	17-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
27677075-9	2016	In vivo treatment of MS-444 inhibited HuR cytoplasmic localization and decreased COX-2 expression in tumors.	5,8-dihydroxy-3-methyl-4-(9H)-naphtho(2,3-c)furanone	21-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-86
27541263-6	2016	The inhibitory activity of COX-2 and 5-LOX were tested for 5a-h. Three compounds, 5c, 5d and 5f showed excellent COX-2 inhibitory activity with IC50 ranging from 0.98 to 1.23 muM compared to the reference celecoxib (1.54 muM).	Celecoxib	205-214	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-38
27774535-1	2016	Partial reductive hydrolysis of a penta-CoII/III cluster [Co(H2O)2(CoIIIW9O34)(PW9O34)]12- (1) leads to the formation of [Co2{Co3(H2O)(Co(OH)2W7O26)(PW9O34)}2]22- (2).	Water	61-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-44
27697529-4	2016	MSCs were transfected with pcDNA-Cox2 and NS-398 to promote or inhibit the expression of Cox2.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	42-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-93
27774535-1	2016	Partial reductive hydrolysis of a penta-CoII/III cluster [Co(H2O)2(CoIIIW9O34)(PW9O34)]12- (1) leads to the formation of [Co2{Co3(H2O)(Co(OH)2W7O26)(PW9O34)}2]22- (2).	N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)-4-((4-fluorobenzyl)oxy)pyridine-2,6-dicarboxamide	122-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-44
27774535-1	2016	Partial reductive hydrolysis of a penta-CoII/III cluster [Co(H2O)2(CoIIIW9O34)(PW9O34)]12- (1) leads to the formation of [Co2{Co3(H2O)(Co(OH)2W7O26)(PW9O34)}2]22- (2).	co3(h2o)	126-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-44
27774535-1	2016	Partial reductive hydrolysis of a penta-CoII/III cluster [Co(H2O)2(CoIIIW9O34)(PW9O34)]12- (1) leads to the formation of [Co2{Co3(H2O)(Co(OH)2W7O26)(PW9O34)}2]22- (2).	co(oh)2w7o26	135-147	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-44
30974663-0	2016	Influences of Alkyl and Aryl Substituents on Iminopyridine Fe(II)- and Co(II)-Catalyzed Isoprene Polymerization.	isoprene	88-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-77
27774535-2	2016	This polyoxometalate is made up of two capping [PW9O34]9- units and two bridging [W7O26]10- units that assemble to encapsulate a novel deca-CoII cluster core comprising octahedral and tetrahedral CoII ions.	polyoxometalate I	5-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-144
30974663-4	2016	In contrast, the Co(II) complexes produced polymers with low molecular weight and relatively high cis-1,4 selectivity.	Polymers	43-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-23
27774535-2	2016	This polyoxometalate is made up of two capping [PW9O34]9- units and two bridging [W7O26]10- units that assemble to encapsulate a novel deca-CoII cluster core comprising octahedral and tetrahedral CoII ions.	polyoxometalate I	5-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	196-200
27537326-6	2016	Increasing COX-2 drug selectivity, as for rofecoxib, valdecoxib, parecoxib, and lumiracoxib, has been associated with higher cardiovascular risk, as well as dermatological and serious hepatic reactions.	rofecoxib	42-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-16
27779319-5	2016	Their IC50 values against the COX-2 enzyme were 0.67 and 0.85 microM, respectively, which is more potent than etoricoxib.	Etoricoxib	110-120	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-35
27811411-0	2016	New homodinuclear tris(3-alkylpyrazolyl)borate complexes of CoII and NiII with a tetraacetylethane dianion as a bridging ligand.	tris(3-alkylpyrazolyl)borate	18-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-64
27811411-0	2016	New homodinuclear tris(3-alkylpyrazolyl)borate complexes of CoII and NiII with a tetraacetylethane dianion as a bridging ligand.	tetraacetylethane dianion	81-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-64
27537326-6	2016	Increasing COX-2 drug selectivity, as for rofecoxib, valdecoxib, parecoxib, and lumiracoxib, has been associated with higher cardiovascular risk, as well as dermatological and serious hepatic reactions.	valdecoxib	53-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-16
27537326-6	2016	Increasing COX-2 drug selectivity, as for rofecoxib, valdecoxib, parecoxib, and lumiracoxib, has been associated with higher cardiovascular risk, as well as dermatological and serious hepatic reactions.	parecoxib	65-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-16
27537326-6	2016	Increasing COX-2 drug selectivity, as for rofecoxib, valdecoxib, parecoxib, and lumiracoxib, has been associated with higher cardiovascular risk, as well as dermatological and serious hepatic reactions.	lumiracoxib	80-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-16
27794413-2	2016	COX-2 catalyzes the transformation of arachidonate to PGE2.	Arachidonic Acid	38-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
27523985-6	2016	Moreover, selective COX-2 inhibitor NSAIDs, such as meloxicam or parecoxib, were advantageous over the non-selective COX-1 and COX-2 inhibitor NSAIDs lornoxicam and diclofenac.	Meloxicam	52-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-25
27523985-6	2016	Moreover, selective COX-2 inhibitor NSAIDs, such as meloxicam or parecoxib, were advantageous over the non-selective COX-1 and COX-2 inhibitor NSAIDs lornoxicam and diclofenac.	parecoxib	65-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-25
27794413-2	2016	COX-2 catalyzes the transformation of arachidonate to PGE2.	Dinoprostone	54-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
27725279-0	2016	Design, synthesis, characterization and antimicrobial/antioxidant activities of 1, 4-dicarbonyl-phenyl-dihydrazide based macrocyclic ligand and its Cu(II), Co(II) and Ni(II) complexes.	1, 4-dicarbonyl-phenyl-dihydrazide	80-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	156-173
27687548-10	2016	Indomethacin, diclofenac, and meloxicam highly upregulated radiation-induced expression of ICAM-1 and COX-2.	Meloxicam	30-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-107
27725279-1	2016	Mononuclear transition metal complexes of Cu(II), Co(II) and Ni(II) with a newly synthesised macrocyclic ligand derived from 1, 4-dicarbonyl-phenyl-dihydrazide and 1,2-diphenylethane-1,2-dione (2:2) have been synthesised.	Metals	23-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-56
27725279-1	2016	Mononuclear transition metal complexes of Cu(II), Co(II) and Ni(II) with a newly synthesised macrocyclic ligand derived from 1, 4-dicarbonyl-phenyl-dihydrazide and 1,2-diphenylethane-1,2-dione (2:2) have been synthesised.	1, 4-dicarbonyl-phenyl-dihydrazide	125-159	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-56
27725279-1	2016	Mononuclear transition metal complexes of Cu(II), Co(II) and Ni(II) with a newly synthesised macrocyclic ligand derived from 1, 4-dicarbonyl-phenyl-dihydrazide and 1,2-diphenylethane-1,2-dione (2:2) have been synthesised.	benzil	164-192	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-56
27826185-7	2016	These selective COX2 inhibitors were docked into the active site of COX2, and showed the same orientation and binding mode to that of celecoxib (selective COX2 inhibitor).	Celecoxib	134-143	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-20
27826185-7	2016	These selective COX2 inhibitors were docked into the active site of COX2, and showed the same orientation and binding mode to that of celecoxib (selective COX2 inhibitor).	Celecoxib	134-143	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-72
27826185-7	2016	These selective COX2 inhibitors were docked into the active site of COX2, and showed the same orientation and binding mode to that of celecoxib (selective COX2 inhibitor).	Celecoxib	134-143	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-72
27826185-8	2016	Docking studies also showed that the SO2NH2 of 5u and 5s is inserted deep inside the selective pocket of the COX2-active site and formed a hydrogen-bond interaction with His90, Arg513, Phe518, Ser353, Gln192, and Ile517, which was further validated by superimposed docked pose with celecoxib.	so2nh2	37-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-113
27826185-8	2016	Docking studies also showed that the SO2NH2 of 5u and 5s is inserted deep inside the selective pocket of the COX2-active site and formed a hydrogen-bond interaction with His90, Arg513, Phe518, Ser353, Gln192, and Ile517, which was further validated by superimposed docked pose with celecoxib.	Hydrogen	139-147	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-113
27826185-8	2016	Docking studies also showed that the SO2NH2 of 5u and 5s is inserted deep inside the selective pocket of the COX2-active site and formed a hydrogen-bond interaction with His90, Arg513, Phe518, Ser353, Gln192, and Ile517, which was further validated by superimposed docked pose with celecoxib.	Celecoxib	282-291	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-113
27479158-13	2016	In this comparative study, the administration of the preferential COX-2 inhibitor Meloxicam via histidine-tryptophan-ketoglutarate showed the best graft-protective attributes and the lowest hepatotoxic side effects.	Meloxicam	82-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-71
27894402-3	2016	Celecoxib, a selective COX-2 inhibitor, is the only non-steroidal anti-inflammatory drug (NSAID) that has been approved for cancer therapy and prevention.	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-28
27687548-0	2016	NSAIDs diclofenac, indomethacin, and meloxicam highly upregulate expression of ICAM-1 and COX-2 induced by X-irradiation in human endothelial cells.	Diclofenac	7-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-95
27687548-0	2016	NSAIDs diclofenac, indomethacin, and meloxicam highly upregulate expression of ICAM-1 and COX-2 induced by X-irradiation in human endothelial cells.	Indomethacin	19-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-95
27687548-0	2016	NSAIDs diclofenac, indomethacin, and meloxicam highly upregulate expression of ICAM-1 and COX-2 induced by X-irradiation in human endothelial cells.	Meloxicam	37-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-95
27687548-10	2016	Indomethacin, diclofenac, and meloxicam highly upregulated radiation-induced expression of ICAM-1 and COX-2.	Indomethacin	0-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-107
27687548-10	2016	Indomethacin, diclofenac, and meloxicam highly upregulated radiation-induced expression of ICAM-1 and COX-2.	Diclofenac	14-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-107
27687548-13	2016	CONCLUSION: Indomethacin, diclofenac, and meloxicam highly upregulated radiation-induced expression of ICAM-1 and COX-2 in HUVECs, which suggests that use of these NSAIDs may increase the effects of ionizing radiation and affect the risk of MI after radiation exposure to the heart.	Indomethacin	12-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-119
27687548-13	2016	CONCLUSION: Indomethacin, diclofenac, and meloxicam highly upregulated radiation-induced expression of ICAM-1 and COX-2 in HUVECs, which suggests that use of these NSAIDs may increase the effects of ionizing radiation and affect the risk of MI after radiation exposure to the heart.	Diclofenac	26-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-119
27687548-13	2016	CONCLUSION: Indomethacin, diclofenac, and meloxicam highly upregulated radiation-induced expression of ICAM-1 and COX-2 in HUVECs, which suggests that use of these NSAIDs may increase the effects of ionizing radiation and affect the risk of MI after radiation exposure to the heart.	Meloxicam	42-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-119
27731868-3	2016	Among metal ions studied, Cr(iii), Mn(ii), Fe(ii), Co(ii), Cu(ii) and Zn(ii) were found to enhance the photocurrent by 30-300%; whereas photocurrent density significantly dropped by 90% in Ni(ii) solution after 90 min of illumination.	Metals	6-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-31
27646116-3	2016	In this study, pretreatment of insulin inhibited MPP+-induced cell membrane damages, which also inhibited the Cox-2 and alpha-synuclein levels.	mangion-purified polysaccharide (Candida albicans)	49-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-115
27731868-3	2016	Among metal ions studied, Cr(iii), Mn(ii), Fe(ii), Co(ii), Cu(ii) and Zn(ii) were found to enhance the photocurrent by 30-300%; whereas photocurrent density significantly dropped by 90% in Ni(ii) solution after 90 min of illumination.	Metals	6-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-40
27731868-3	2016	Among metal ions studied, Cr(iii), Mn(ii), Fe(ii), Co(ii), Cu(ii) and Zn(ii) were found to enhance the photocurrent by 30-300%; whereas photocurrent density significantly dropped by 90% in Ni(ii) solution after 90 min of illumination.	Metals	6-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-57
27731868-3	2016	Among metal ions studied, Cr(iii), Mn(ii), Fe(ii), Co(ii), Cu(ii) and Zn(ii) were found to enhance the photocurrent by 30-300%; whereas photocurrent density significantly dropped by 90% in Ni(ii) solution after 90 min of illumination.	Metals	6-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-40
27731868-3	2016	Among metal ions studied, Cr(iii), Mn(ii), Fe(ii), Co(ii), Cu(ii) and Zn(ii) were found to enhance the photocurrent by 30-300%; whereas photocurrent density significantly dropped by 90% in Ni(ii) solution after 90 min of illumination.	Metals	6-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-40
27731868-3	2016	Among metal ions studied, Cr(iii), Mn(ii), Fe(ii), Co(ii), Cu(ii) and Zn(ii) were found to enhance the photocurrent by 30-300%; whereas photocurrent density significantly dropped by 90% in Ni(ii) solution after 90 min of illumination.	Metals	6-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-40
27731868-3	2016	Among metal ions studied, Cr(iii), Mn(ii), Fe(ii), Co(ii), Cu(ii) and Zn(ii) were found to enhance the photocurrent by 30-300%; whereas photocurrent density significantly dropped by 90% in Ni(ii) solution after 90 min of illumination.	tris(1,10-phenanthroline)chromium(III) chloride	26-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-40
27731868-3	2016	Among metal ions studied, Cr(iii), Mn(ii), Fe(ii), Co(ii), Cu(ii) and Zn(ii) were found to enhance the photocurrent by 30-300%; whereas photocurrent density significantly dropped by 90% in Ni(ii) solution after 90 min of illumination.	tris(1,10-phenanthroline)chromium(III) chloride	26-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-57
27731868-3	2016	Among metal ions studied, Cr(iii), Mn(ii), Fe(ii), Co(ii), Cu(ii) and Zn(ii) were found to enhance the photocurrent by 30-300%; whereas photocurrent density significantly dropped by 90% in Ni(ii) solution after 90 min of illumination.	tris(1,10-phenanthroline)chromium(III) chloride	26-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-40
27731868-3	2016	Among metal ions studied, Cr(iii), Mn(ii), Fe(ii), Co(ii), Cu(ii) and Zn(ii) were found to enhance the photocurrent by 30-300%; whereas photocurrent density significantly dropped by 90% in Ni(ii) solution after 90 min of illumination.	tris(1,10-phenanthroline)chromium(III) chloride	26-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-40
27731868-3	2016	Among metal ions studied, Cr(iii), Mn(ii), Fe(ii), Co(ii), Cu(ii) and Zn(ii) were found to enhance the photocurrent by 30-300%; whereas photocurrent density significantly dropped by 90% in Ni(ii) solution after 90 min of illumination.	tris(1,10-phenanthroline)chromium(III) chloride	26-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-40
27768866-1	2016	Prostaglandins have been characterized as the metabolic products of arachidonic acid released from glycerophospholipids following hydrolysis by phospholipase A2s and enzymatic oxidation by the COX1 and COX2.	Glycerophospholipids	99-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	202-206
27768866-3	2016	(2016) examine the metabolism of 2-arachidonoyl-lyso-phosphatidylcholine and 2-arachidonoyl-lyso-phosphatidylethanolamine by COX2 and conversion to glycerolipid linked prostanoids, raising a series of interesting and important questions.	2-arachidonoyllysophosphatidylcholine	33-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-129
27768866-1	2016	Prostaglandins have been characterized as the metabolic products of arachidonic acid released from glycerophospholipids following hydrolysis by phospholipase A2s and enzymatic oxidation by the COX1 and COX2.	Prostaglandins	0-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	202-206
27768866-1	2016	Prostaglandins have been characterized as the metabolic products of arachidonic acid released from glycerophospholipids following hydrolysis by phospholipase A2s and enzymatic oxidation by the COX1 and COX2.	Arachidonic Acid	68-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	202-206
27768866-3	2016	(2016) examine the metabolism of 2-arachidonoyl-lyso-phosphatidylcholine and 2-arachidonoyl-lyso-phosphatidylethanolamine by COX2 and conversion to glycerolipid linked prostanoids, raising a series of interesting and important questions.	2-arachidonoyl-lyso-phosphatidylethanolamine	77-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-129
27768866-3	2016	(2016) examine the metabolism of 2-arachidonoyl-lyso-phosphatidylcholine and 2-arachidonoyl-lyso-phosphatidylethanolamine by COX2 and conversion to glycerolipid linked prostanoids, raising a series of interesting and important questions.	glycerolipid	148-160	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-129
27768866-3	2016	(2016) examine the metabolism of 2-arachidonoyl-lyso-phosphatidylcholine and 2-arachidonoyl-lyso-phosphatidylethanolamine by COX2 and conversion to glycerolipid linked prostanoids, raising a series of interesting and important questions.	Prostaglandins	168-179	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-129
30860381-4	2016	Inhibited COX-2 (44 +- 6%) and iNOS (15 +- 7%) expression played a role in reducing the production of prostaglandin E2 (40 +- 20%) and NO (31 +- 9%), respectively.	Dinoprostone	102-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
27612418-6	2016	Mebendazole as a single agent decreased COX2 expression, blood vessel formation, VEGFR2 phosphorylation, and worked synergistically with sulindac to reduce overexpression of MYC, BCL2, and various pro-inflammatory cytokines.	Mebendazole	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-44
27673751-0	2016	Distorted Tetrahedral CoII in K5H[CoW12O40] xH2O Probed by 2p3d Resonant Inelastic X-ray Scattering.	k5h	30-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-26
28097001-8	2016	Although 0.1 mumol/L MAG-DPA did not significantly reduce inflammatory biomarkers, the higher concentrations of MAG-DPA (0.3 and 1 mumol/L) blunted the activation of the TNF-alpha/NF kappaB pathway and abolished COX-2 expression in human and guinea pig tissues.	1-O-docosapentaenoylglycerol	112-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	212-217
27673751-0	2016	Distorted Tetrahedral CoII in K5H[CoW12O40] xH2O Probed by 2p3d Resonant Inelastic X-ray Scattering.	[cow12o40] xh2o	33-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-26
27736969-0	2016	Downregulation of HOTAIR Expression Mediated Anti-Metastatic Effect of Artesunate on Cervical Cancer by Inhibiting COX-2 Expression.	Artesunate	71-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-120
30974640-6	2016	The Co(II) doping into polysilazane leads to the emission from 465 to 415 nm.	polysilazane	23-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
27690397-4	2016	The CoII-LnIII assembly was synthesized from Ln(NO3)3 xH2O/Co(OAc)2 4H2O/H2vab/NaOMe in a 0.4:0.5:1:1 ratio in methanol.	ln(no3)3 xh2o	45-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-8
27690397-4	2016	The CoII-LnIII assembly was synthesized from Ln(NO3)3 xH2O/Co(OAc)2 4H2O/H2vab/NaOMe in a 0.4:0.5:1:1 ratio in methanol.	co(oac)2 4h2o	59-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-8
27690397-4	2016	The CoII-LnIII assembly was synthesized from Ln(NO3)3 xH2O/Co(OAc)2 4H2O/H2vab/NaOMe in a 0.4:0.5:1:1 ratio in methanol.	h2vab	73-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-8
27690397-4	2016	The CoII-LnIII assembly was synthesized from Ln(NO3)3 xH2O/Co(OAc)2 4H2O/H2vab/NaOMe in a 0.4:0.5:1:1 ratio in methanol.	Sodium methanolate	79-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-8
27690397-4	2016	The CoII-LnIII assembly was synthesized from Ln(NO3)3 xH2O/Co(OAc)2 4H2O/H2vab/NaOMe in a 0.4:0.5:1:1 ratio in methanol.	Methanol	111-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-8
27519123-2	2016	This works describes an unusual large easy-plane magnetic anisotropy (with a zero-field splitting parameter D of +40.2 cm-1 ), mainly arising from the second-order spin-orbit coupling effect in a trigonal-planar CoII complex [Li(THF)4 ][Co(NPh2 )3 ], revealed by combined studies of magnetism, high frequency/field electron paramagnetic resonance spectroscopy, and ab initio calculations.	li(thf)4	226-234	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	212-216
27632142-1	2016	In this article we report the synthesis and structure of the new Co(II) complex Et4N[CoII(hfac)3] (I) (hfac = hexafluoroacetylacetonate) exhibiting single-ion magnet (SIM) behavior.	et4n	80-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-71
27318118-1	2016	A new series of 2-substituted mercapto-4(3H)-quinazolinone 1-26 were synthesized and assessed for in vivo anti-inflammatory and analgesic activities and in vitro inhibition of cyclooxygenase COX-1/COX-2.	2-substituted mercapto-4(3h)-quinazolinone 1-26	16-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	197-202
27632142-1	2016	In this article we report the synthesis and structure of the new Co(II) complex Et4N[CoII(hfac)3] (I) (hfac = hexafluoroacetylacetonate) exhibiting single-ion magnet (SIM) behavior.	hexafluoroacetylacetonate	110-135	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-71
27695098-0	2016	Regulation of Matrix Metalloproteinase-2 Activity by COX-2-PGE2-pAKT Axis Promotes Angiogenesis in Endometriosis.	Dinoprostone	59-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-58
27636564-1	2016	This study reports the static and dynamic magnetic characterization of two mononuclear tetrahedral CoII complexes, [Co{iPr2P(E)NP(E)iPr2}2], where E = S (CoS4) and Se (CoSe4), which behave as single-ion magnets (SIMs).	cos4	154-158	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-103
27413198-7	2016	To study the potential mechanisms in mediating the rotenone effects on AQPs, we examined the regulation of the COX-2/microsomal prostaglandin E synthase (mPGES)-1/PGE2/EP pathway and found that COX-2, mPGES-1, and renal PGE2 content were all significantly elevated in obstructive kidneys, which was not affected by rotenone treatment.	Rotenone	51-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	111-116
27636564-1	2016	This study reports the static and dynamic magnetic characterization of two mononuclear tetrahedral CoII complexes, [Co{iPr2P(E)NP(E)iPr2}2], where E = S (CoS4) and Se (CoSe4), which behave as single-ion magnets (SIMs).	Selenium	164-166	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-103
27636564-1	2016	This study reports the static and dynamic magnetic characterization of two mononuclear tetrahedral CoII complexes, [Co{iPr2P(E)NP(E)iPr2}2], where E = S (CoS4) and Se (CoSe4), which behave as single-ion magnets (SIMs).	cose4	168-173	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-103
27636564-5	2016	Moreover, alternating-current susceptibility measurements on these CoII complexes, magnetically diluted in their isostructural ZnII analogues, highlight the role of dipolar magnetic coupling in the mechanism of magnetization reversal.	Zinc	127-131	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-71
27601359-3	2016	Compound 13h was the most COX-2 selective compound (COX-2 selectivity index (SI) = 10.23) and the most potent anti-inflammatory derivative (ED50  = 60.1 micromol/kg) in comparison with celecoxib (COX-2 SI = 9.29 and ED50  = 81.4 micromol/kg).	13h	9-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-31
27601359-3	2016	Compound 13h was the most COX-2 selective compound (COX-2 selectivity index (SI) = 10.23) and the most potent anti-inflammatory derivative (ED50  = 60.1 micromol/kg) in comparison with celecoxib (COX-2 SI = 9.29 and ED50  = 81.4 micromol/kg).	13h	9-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-57
27601359-3	2016	Compound 13h was the most COX-2 selective compound (COX-2 selectivity index (SI) = 10.23) and the most potent anti-inflammatory derivative (ED50  = 60.1 micromol/kg) in comparison with celecoxib (COX-2 SI = 9.29 and ED50  = 81.4 micromol/kg).	13h	9-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-57
27567369-5	2016	Among the screened compounds, tetrazole 4i showed the best inhibition potency and selectivity values for both COX-2 enzyme (IC50=3muM, SI&gt;67) and COX-1 isoenzyme (IC50&gt;200muM).	tetrazole 4i	30-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-115
27317138-4	2016	Products of COX-2 activity (e.g. PGE2 and prostacyclin) are involved in diverse physiological and pathophysiological processes, including renal haemodynamics and the control of blood pressure, endothelial thromboresistance, pain and inflammation, and colorectal tumorigenesis.	Dinoprostone	33-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-17
27317138-4	2016	Products of COX-2 activity (e.g. PGE2 and prostacyclin) are involved in diverse physiological and pathophysiological processes, including renal haemodynamics and the control of blood pressure, endothelial thromboresistance, pain and inflammation, and colorectal tumorigenesis.	Epoprostenol	42-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-17
27344083-7	2016	The aspirin-mediated inactivation of platelets may restore antitumor reactivity by blocking the release of paracrine lipid and protein mediators that induce COX-2 expression in adjacent nucleated cells at sites of mucosal injury.	Aspirin	4-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	157-162
27592455-6	2016	Moreover, lentiviral-mediated overexpression of cytochrome c oxidase subunit II antagonized the decrease in ATP synthesis caused by knockdown of tumor necrosis factor receptor-associated protein 1, whereas knockdown of cytochrome c oxidase subunit II attenuated the increase in ATP synthesis caused by overexpression of tumor necrosis factor receptor-associated protein 1.	Adenosine Triphosphate	108-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-79
27592455-6	2016	Moreover, lentiviral-mediated overexpression of cytochrome c oxidase subunit II antagonized the decrease in ATP synthesis caused by knockdown of tumor necrosis factor receptor-associated protein 1, whereas knockdown of cytochrome c oxidase subunit II attenuated the increase in ATP synthesis caused by overexpression of tumor necrosis factor receptor-associated protein 1.	Adenosine Triphosphate	278-281	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-79
27592455-6	2016	Moreover, lentiviral-mediated overexpression of cytochrome c oxidase subunit II antagonized the decrease in ATP synthesis caused by knockdown of tumor necrosis factor receptor-associated protein 1, whereas knockdown of cytochrome c oxidase subunit II attenuated the increase in ATP synthesis caused by overexpression of tumor necrosis factor receptor-associated protein 1.	Adenosine Triphosphate	278-281	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	219-250
27592455-7	2016	In addition, inhibition of cytochrome c oxidase subunit II by a specific inhibitor sodium azide suppressed the ATP sy nthesis induced by overexpressed tumor necrosis factor receptor-associated protein 1.	Sodium Azide	83-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-58
27592455-7	2016	In addition, inhibition of cytochrome c oxidase subunit II by a specific inhibitor sodium azide suppressed the ATP sy nthesis induced by overexpressed tumor necrosis factor receptor-associated protein 1.	Adenosine Triphosphate	111-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-58
27619024-9	2016	The amount of COX-2 protein production was significantly decreased by metformin pretreatment (4 mM, p = 0.01).	Metformin	70-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
27384335-7	2016	Furthermore, DPSC/I-DPSC-mediated inhibition of TNF-alpha secretion by macrophages was abolished by pretreatment with 1-methyl-D-tryptophan, a specific inhibitor of indoleamine-pyrrole 2,3-dioxygenase (IDO), but not by NSC-398, a specific inhibitor of COX-2, suggesting IDO as a mediator.	1-methyltryptophan	118-139	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	252-257
27567143-2	2016	Cbl(II) (Co(II)) is rapidly oxidized by HOCl to predominately aquacobalamin/hydroxycobalamin (Cbl(III), Co(III)) with a second-order rate constant of 2.4x107M-1s-1 (25.0 C).	Hypochlorous Acid	40-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	9-15
27567143-2	2016	Cbl(II) (Co(II)) is rapidly oxidized by HOCl to predominately aquacobalamin/hydroxycobalamin (Cbl(III), Co(III)) with a second-order rate constant of 2.4x107M-1s-1 (25.0 C).	aquacobalamin/hydroxycobalamin	62-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	9-15
27695098-9	2016	Inhibition of COX-2 and/or phosphorylated AKT suppressed MMP-2 activity and endothelial tube formation suggesting involvement of PGE2 in regulation of MMP-2 activity during angiogenesis.	Dinoprostone	129-133	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
27695098-13	2016	In conclusion, our study establishes the involvement of MMP-2 activity via COX-2-PGE2-pAKT axis in promoting angiogenesis during endometriosis progression.	Dinoprostone	81-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
28077888-1	2016	OBJECTIVE: Virtual molecular dynamic sesquiterpenoid Pogostemon Herba (CID56928117, CID94275, CID107152, and CID519743) have screening as cyclooxygenase (COX-1/COX-2) selective inhibitor.	sesquiterpenoid	37-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	160-165
28077888-2	2016	METHODS: Molecular interaction studies sesquiterpenoid compounds with COX-1 and COX-2 were using the molecular docking tools by Hex 8.0 and interactions were further visualized using by Discovery Studio Client 3.5 software tool and Virtual Molecular Dynamic 1.9.1 software.	sesquiterpenoid	39-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-85
28077888-4	2016	RESULT: The analysis of the sesquiterpenoid compounds showed that CID56928117, CID94275, CID107152, and CID519743 have suggested as inhibitor of COX-1 and COX-2.	sesquiterpenoid	28-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	155-160
28077888-5	2016	CONCLUSION: Collectively, the scoring binding energy calculation (with PBSA Model Solvent) sesquiterpenoid compounds: CID519743 had suggested as candidate for non-selective inhibitor; CID56928117 and CID94275 had suggested as candidate for a selective COX-1 inhibitor; and CID107152 had suggested as candidate for a selective COX-2 inhibitor.	poly(tetramethylene succinate-co-tetramethylene adipate)	71-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	326-331
28077888-5	2016	CONCLUSION: Collectively, the scoring binding energy calculation (with PBSA Model Solvent) sesquiterpenoid compounds: CID519743 had suggested as candidate for non-selective inhibitor; CID56928117 and CID94275 had suggested as candidate for a selective COX-1 inhibitor; and CID107152 had suggested as candidate for a selective COX-2 inhibitor.	sesquiterpenoid	91-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	326-331
28077888-5	2016	CONCLUSION: Collectively, the scoring binding energy calculation (with PBSA Model Solvent) sesquiterpenoid compounds: CID519743 had suggested as candidate for non-selective inhibitor; CID56928117 and CID94275 had suggested as candidate for a selective COX-1 inhibitor; and CID107152 had suggested as candidate for a selective COX-2 inhibitor.	cid519743	118-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	326-331
28077888-5	2016	CONCLUSION: Collectively, the scoring binding energy calculation (with PBSA Model Solvent) sesquiterpenoid compounds: CID519743 had suggested as candidate for non-selective inhibitor; CID56928117 and CID94275 had suggested as candidate for a selective COX-1 inhibitor; and CID107152 had suggested as candidate for a selective COX-2 inhibitor.	cid56928117	184-195	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	326-331
28077888-5	2016	CONCLUSION: Collectively, the scoring binding energy calculation (with PBSA Model Solvent) sesquiterpenoid compounds: CID519743 had suggested as candidate for non-selective inhibitor; CID56928117 and CID94275 had suggested as candidate for a selective COX-1 inhibitor; and CID107152 had suggested as candidate for a selective COX-2 inhibitor.	cid94275	200-208	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	326-331
28077888-5	2016	CONCLUSION: Collectively, the scoring binding energy calculation (with PBSA Model Solvent) sesquiterpenoid compounds: CID519743 had suggested as candidate for non-selective inhibitor; CID56928117 and CID94275 had suggested as candidate for a selective COX-1 inhibitor; and CID107152 had suggested as candidate for a selective COX-2 inhibitor.	cid107152	273-282	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	326-331
27520485-11	2016	Chromatin immunoprecipitation assays showed that TPA elevated H3K27Ac enrichment in the COX2 promoter region, which is mediated by p300, and Brd4.	Tetradecanoylphorbol Acetate	49-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-92
27317138-2	2016	The rest of the Themed section will appear in a future issue of BJP and will be available at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1476-5381 Prostaglandin (PG) H synthase 2 [also referred to colloquially as cyclooxygenase (COX) 2] represents a key enzyme in arachidonic acid metabolism in health and disease.	Prostaglandins	156-169	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	222-244
27831630-2	2016	Data collected during the last 10 years reported a dose-duration dependent increasing of cardiovascular risk associated with the use of diclofenac, supporting the evidence of a close association with the degree of COX-2 inhibition achieved in vivo.	Diclofenac	136-146	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	214-219
27831630-6	2016	Today, new low-dosage diclofenac formulations are available, allowing to reduce the systemic exposure, the degree of COX-2 inhibition and possibly the risk of occurrence of cardiovascular events.	Diclofenac	22-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-122
27413198-7	2016	To study the potential mechanisms in mediating the rotenone effects on AQPs, we examined the regulation of the COX-2/microsomal prostaglandin E synthase (mPGES)-1/PGE2/EP pathway and found that COX-2, mPGES-1, and renal PGE2 content were all significantly elevated in obstructive kidneys, which was not affected by rotenone treatment.	Rotenone	51-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	194-199
27562882-0	2016	Synthesis of Co(II)-NO(-) Complexes and Their Reactivity as a Source of Nitroxyl.	nitroxyl	72-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-19
27562882-3	2016	Experimental (NMR, IR, MS, EPR, XAS, XRD) and computational data (DFT) support an oxidation state assignment for 3 and 4 of high spin Co(II) (SCo = 3/2) coordinated to (3)NO(-) (SNO = 1) for Stot = 1/2.	(3)no	168-173	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-140
27420768-1	2016	A new pentanuclear "cylinder"-like cobalt(ii) phenylsilsesquioxane [(PhSiO1.5)10(CoO)5(NaOH)] exhibits a slow relaxation of the magnetization and a high catalytic activity and stereoselectivity in the oxidation of alkanes and alcohols.	(phsio1.5)10(coo)5	68-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-44
27086708-0	2016	Tolerability of the COX-1/COX-2 inhibitor lornoxicam in the treatment of acute and rheumatic pain.	lornoxicam	42-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-31
27746942-2	2016	The CoII ion is coordinated in a slightly distorted trigonal-bipyramidal environment which is defined by three O atoms occupying the equatorial plane and the N and Cl atoms in the apical sites.	Nitrogen	158-159	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-8
27420768-1	2016	A new pentanuclear "cylinder"-like cobalt(ii) phenylsilsesquioxane [(PhSiO1.5)10(CoO)5(NaOH)] exhibits a slow relaxation of the magnetization and a high catalytic activity and stereoselectivity in the oxidation of alkanes and alcohols.	naoh)	87-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-44
27420768-1	2016	A new pentanuclear "cylinder"-like cobalt(ii) phenylsilsesquioxane [(PhSiO1.5)10(CoO)5(NaOH)] exhibits a slow relaxation of the magnetization and a high catalytic activity and stereoselectivity in the oxidation of alkanes and alcohols.	Alkanes	214-221	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-44
27420768-1	2016	A new pentanuclear "cylinder"-like cobalt(ii) phenylsilsesquioxane [(PhSiO1.5)10(CoO)5(NaOH)] exhibits a slow relaxation of the magnetization and a high catalytic activity and stereoselectivity in the oxidation of alkanes and alcohols.	Alcohols	226-234	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-44
27457782-1	2016	A simple admixture of Co(II) -salcy complexes with [Cp2 Fe(III) ]PF6 resulted in reproduction of the results with isolated Co(III) -salcy complexes in the copolymerization of epoxide and carbon dioxide.	Carbon Dioxide	187-201	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-28
27628421-0	2016	Influence of Genetic Polymorphisms in Prostaglandin E2 Pathway (COX-2/HPGD/SLCO2A1/ABCC4) on the Risk for Colorectal Adenoma Development and Recurrence after Polypectomy.	Dinoprostone	38-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-69
27628421-2	2016	Our aim was to evaluate the influence of the genetic variability in COX-2/HPGD/SLCO2A1/ABCC4 PGE2 pathway genes on the development and recurrence of colorectal adenomas.	Dinoprostone	93-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-73
27628421-9	2016	CONCLUSIONS: Genetic polymorphisms in COX-2/PGE2 pathway appear to contribute to the development of colorectal adenomas and influence the interval time to adenomas recurrence.	Dinoprostone	44-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-43
27560462-3	2016	This Co(II) (H2 O2 ) compound is made observable by incorporating second-sphere hydrogen-bonding interactions between bound H2 O2 and the supporting ligand, a trianionic trisulfonamido ligand.	Hydrogen Peroxide	13-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	5-11
27560462-3	2016	This Co(II) (H2 O2 ) compound is made observable by incorporating second-sphere hydrogen-bonding interactions between bound H2 O2 and the supporting ligand, a trianionic trisulfonamido ligand.	Hydrogen	80-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	5-11
27560462-3	2016	This Co(II) (H2 O2 ) compound is made observable by incorporating second-sphere hydrogen-bonding interactions between bound H2 O2 and the supporting ligand, a trianionic trisulfonamido ligand.	Hydrogen Peroxide	124-129	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	5-11
27560462-4	2016	Thermodynamics of H2 O2 binding and decay kinetics of the Co(II) (H2 O2 ) species are described, as well as the reaction of this Co(II) (H2 O2 ) species with Group 2 cations.	Hydrogen Peroxide	18-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-64
27560462-4	2016	Thermodynamics of H2 O2 binding and decay kinetics of the Co(II) (H2 O2 ) species are described, as well as the reaction of this Co(II) (H2 O2 ) species with Group 2 cations.	Hydrogen Peroxide	66-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-64
27560462-4	2016	Thermodynamics of H2 O2 binding and decay kinetics of the Co(II) (H2 O2 ) species are described, as well as the reaction of this Co(II) (H2 O2 ) species with Group 2 cations.	Hydrogen Peroxide	137-144	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-135
27470422-3	2016	The present study shows that acute Cr(VI) treatment in human bronchial epithelial cells (BEAS-2B) increased inflammatory responses (TNF-alpha, COX-2, and NF-kB/p65) and expression of Nrf2.	Chromium	35-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	143-148
27711752-0	2016	Anti-inflammatory activity and enhanced COX-2 selectivity of nitric oxide-donating zinc(ii)-NSAID complexes.	Nitric Oxide	61-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
27711752-0	2016	Anti-inflammatory activity and enhanced COX-2 selectivity of nitric oxide-donating zinc(ii)-NSAID complexes.	Zinc	83-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
27711752-1	2016	Zinc(ii)-NSAID complexes supported by NO-donating 1,10-phenanthrolinefuroxan exhibit anti-inflammatory activities through selective inhibition of the COX-2 pathway.	Zinc	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	150-155
27711752-1	2016	Zinc(ii)-NSAID complexes supported by NO-donating 1,10-phenanthrolinefuroxan exhibit anti-inflammatory activities through selective inhibition of the COX-2 pathway.	1,10-phenanthrolinefuroxan	50-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	150-155
27457782-1	2016	A simple admixture of Co(II) -salcy complexes with [Cp2 Fe(III) ]PF6 resulted in reproduction of the results with isolated Co(III) -salcy complexes in the copolymerization of epoxide and carbon dioxide.	Epoxy Compounds	175-182	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-28
27457782-3	2016	In contrast, the Co(II) -salcy complex substituted with the more strongly electron-donating NMe2 group did not show any activity for this copolymerization.	salcy	25-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-23
27500422-3	2016	In both structures, the Co(II) centers adopt octahedral {CoN2O4} geometries filled by pairs of mutually trans terminal 3,5-dnb, py, and water ligands.	con2o4	57-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-30
27422817-8	2016	We also found that the COX2 inhibitor NS398 down-regulated DNMTs and increased expression of SPARC, which led to tumor growth suppression in bone in vivo These findings suggest that SPARC plays a key role in maintaining the dormancy of prostate cancer cells in the bone microenvironment.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	38-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-27
27475498-0	2016	Structural insight into the inhibition of carbonic anhydrase by the COX-2-selective inhibitor polmacoxib (CG100649).	CG100649	94-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-73
27475498-0	2016	Structural insight into the inhibition of carbonic anhydrase by the COX-2-selective inhibitor polmacoxib (CG100649).	CG100649	106-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-73
27475498-1	2016	Polmacoxib is not only a selective COX-2 inhibitor but also a potent inhibitor of carbonic anhydrases (CAs).	CG100649	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40
27475498-3	2016	By inhibition assays, we show that both CA I and CA II are strongly inhibited by polmacoxib, while CA II also demonstrates direct competition with COX-2.	CG100649	81-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-152
27500422-3	2016	In both structures, the Co(II) centers adopt octahedral {CoN2O4} geometries filled by pairs of mutually trans terminal 3,5-dnb, py, and water ligands.	3,5-dnb	119-126	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-30
27500422-3	2016	In both structures, the Co(II) centers adopt octahedral {CoN2O4} geometries filled by pairs of mutually trans terminal 3,5-dnb, py, and water ligands.	pyridine	128-130	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-30
27500422-3	2016	In both structures, the Co(II) centers adopt octahedral {CoN2O4} geometries filled by pairs of mutually trans terminal 3,5-dnb, py, and water ligands.	Water	136-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-30
27433926-1	2016	In the presence of a molecular Co(II) catalyst, CO2 reduction occurred at much less negative potentials on Si photoelectrodes than on an Au electrode.	N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)-4-((4-fluorobenzyl)oxy)pyridine-2,6-dicarboxamide	48-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-37
29638057-9	2016	Molecular docking studies showed that the tested compounds induced good fitting and forming different hydrogen bonds with the amino acid residues at the active sites of COX-2 enzyme.	Hydrogen	102-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	169-174
27433926-1	2016	In the presence of a molecular Co(II) catalyst, CO2 reduction occurred at much less negative potentials on Si photoelectrodes than on an Au electrode.	Silicon	107-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-37
27433926-1	2016	In the presence of a molecular Co(II) catalyst, CO2 reduction occurred at much less negative potentials on Si photoelectrodes than on an Au electrode.	Gold	137-139	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-37
27433926-2	2016	The addition of 1 % H2 O significantly improved the performance of the Co(II) catalyst.	Water	20-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-77
27432344-1	2016	Treatment with celecoxib, a selective COX-2 inhibitor, reduces formation of premalignant adenomatous polyps in the gastrointestinal tracts of humans and mice.	Celecoxib	15-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-43
27321932-6	2016	Even more, hCOX-2-Tg mice treated with CCl4 had significantly lower stages of fibrosis and less hepatic content of collagen, hydroxyproline and pro-fibrogenic markers than Wt controls.	Hydroxyproline	125-139	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-17
27490211-12	2016	Tideglusib reported a significant dose-dependent increase in pro-apoptotic proteins (PARP, Caspase-9, Caspase-7, Caspase-3) and tumor-related genes (FasL, TNF-alpha, Cox-2, IL-8, Caspase-3).	tideglusib	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	166-171
26378497-10	2016	Using transient transfection of the COX-2 promoter, UDCA pretreatment abrogated DCA-induced COX-2 promoter activation.	Deoxycholic Acid	53-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-41
26378497-10	2016	Using transient transfection of the COX-2 promoter, UDCA pretreatment abrogated DCA-induced COX-2 promoter activation.	Deoxycholic Acid	53-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-97
27318652-0	2016	Interaction between COX-1 and COX-2 Variants Associated with Aspirin Resistance in Chinese Stroke Patients.	Aspirin	61-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-35
27395793-1	2016	Three new nano sized Cu(II), Co(II) and Ni(II) complexes of imine ligand derived from the condensation of 2-amino-3-hydroxypyridine and 3-methoxysalicylaldehyde have been prepared and investigated using various chemical techniques such as NMR, elemental analysis, molar conductance, IR, electronic spectra, TGA and magnetic moment measurements.	Imines	60-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-35
27395793-1	2016	Three new nano sized Cu(II), Co(II) and Ni(II) complexes of imine ligand derived from the condensation of 2-amino-3-hydroxypyridine and 3-methoxysalicylaldehyde have been prepared and investigated using various chemical techniques such as NMR, elemental analysis, molar conductance, IR, electronic spectra, TGA and magnetic moment measurements.	2-amino-3-hydroxypyridine	106-131	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-35
27395793-1	2016	Three new nano sized Cu(II), Co(II) and Ni(II) complexes of imine ligand derived from the condensation of 2-amino-3-hydroxypyridine and 3-methoxysalicylaldehyde have been prepared and investigated using various chemical techniques such as NMR, elemental analysis, molar conductance, IR, electronic spectra, TGA and magnetic moment measurements.	2-vanillin	136-160	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-35
27301070-2	2016	We established that cyclo-oxygenase(COX)-2 expression promotes human breast cancer progression by activation of the prostaglandin(PG)E-2 receptor EP4.	prostaglandin(pg	116-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-42
27484716-7	2016	The results demonstrated that celastrol significantly attenuated the expression of IL-6, IL-8, cyclooxygenase (COX)-2 and intercellular adhesion molecule-1 (ICAM-1), and inhibited IL-1beta-induced increases in the expression of IL-6, IL-8, ICAM-1 and COX-2.	celastrol	30-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-117
27484716-7	2016	The results demonstrated that celastrol significantly attenuated the expression of IL-6, IL-8, cyclooxygenase (COX)-2 and intercellular adhesion molecule-1 (ICAM-1), and inhibited IL-1beta-induced increases in the expression of IL-6, IL-8, ICAM-1 and COX-2.	celastrol	30-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	251-256
27343605-0	2016	Sulphate radical generation through interaction of peroxymonosulphate with Co(II) for in-line sample preparation aiming at spectrophotometric flow-based determination of phosphate and phosphite in fertilizers.	sulphate radical	0-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-81
27343605-0	2016	Sulphate radical generation through interaction of peroxymonosulphate with Co(II) for in-line sample preparation aiming at spectrophotometric flow-based determination of phosphate and phosphite in fertilizers.	Phosphates	170-179	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-81
27343605-0	2016	Sulphate radical generation through interaction of peroxymonosulphate with Co(II) for in-line sample preparation aiming at spectrophotometric flow-based determination of phosphate and phosphite in fertilizers.	Phosphites	184-193	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-81
27224899-0	2016	Zeranol induces COX-2 expression through TRPC-3 activation in the placental cells JEG-3.	Zeranol	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-21
27224899-9	2016	In response to the calcium flow, ERK, P38 and PKCbeta were activated and COX-2 expression was increased.	Calcium	19-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-78
27548780-7	2016	COX-2 inhibition activity of diclofenac was retained when conjugated to DKP.	Diclofenac	29-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
27539669-3	2016	Our previous study has shown that human chorionic gonadotropin (hCG)/luteinizing hormone (LH) up-regulates the expression levels of EGF-like growth factor, amphiregulin (AREG), which subsequently contributes to the hCG/LH-induced COX-2 expression and PGE2 production.	Dinoprostone	251-255	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	230-235
27344214-1	2016	A new series, 2-substituted mercapto-3-[2-(pyridin-2-yl)ethyl]-4(3H)-quinazolinone 1-21, was synthesized and evaluated for in vivo anti-inflammatory and analgesic activities and in vitro COX-1/COX-2 inhibition.	2-substituted mercapto-3-[2-(pyridin-2-yl)ethyl]-4(3h)-quinazolinone	14-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	193-198
26335394-0	2016	COX-2, aspirin and metabolism of arachidonic, eicosapentaenoic and docosahexaenoic acids and their physiological and clinical significance.	arachidonic	33-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
26335394-0	2016	COX-2, aspirin and metabolism of arachidonic, eicosapentaenoic and docosahexaenoic acids and their physiological and clinical significance.	eicosapentaenoic	46-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
26335394-0	2016	COX-2, aspirin and metabolism of arachidonic, eicosapentaenoic and docosahexaenoic acids and their physiological and clinical significance.	Docosahexaenoic Acids	67-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
27502582-0	2016	Evaluation of two doses of etoricoxib, a COX-2 selective non-steroidal anti-inflammatory drug (NSAID), in the treatment of Rheumatoid Arthritis in a double-blind, randomized controlled trial.	Etoricoxib	27-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-46
27502582-2	2016	Etoricoxib is a COX-2 selective NSAID that has demonstrated efficacy in the treatment of RA at a dose of 90 mg.	Etoricoxib	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-21
27107323-1	2016	Degradation of tetrabromobisphenol A (TBBPA), a flame retardant widely spread in the environment, in Co(II) catalyzed peroxymonosulfate (PMS) oxidation process was systematically explored.	tetrabromobisphenol A	15-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-107
27107323-1	2016	Degradation of tetrabromobisphenol A (TBBPA), a flame retardant widely spread in the environment, in Co(II) catalyzed peroxymonosulfate (PMS) oxidation process was systematically explored.	tetrabromobisphenol A	38-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-107
27107323-1	2016	Degradation of tetrabromobisphenol A (TBBPA), a flame retardant widely spread in the environment, in Co(II) catalyzed peroxymonosulfate (PMS) oxidation process was systematically explored.	peroxymonosulfate	118-135	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-107
27107323-1	2016	Degradation of tetrabromobisphenol A (TBBPA), a flame retardant widely spread in the environment, in Co(II) catalyzed peroxymonosulfate (PMS) oxidation process was systematically explored.	peroxymonosulfate	137-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-107
27107323-3	2016	Apparently, degradation of TBBPA showed first-order kinetics to the concentrations of both Co(II) and PMS.	tetrabromobisphenol A	27-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-97
27107323-7	2016	Further oxidative degradation of intermediates in Co(II)/PMS process yielded brominated disinfection by-products (Br-DBPs) such as bromoform and brominated acetic acids.	peroxymonosulfate	57-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-56
27107323-7	2016	Further oxidative degradation of intermediates in Co(II)/PMS process yielded brominated disinfection by-products (Br-DBPs) such as bromoform and brominated acetic acids.	br-dbps	114-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-56
27107323-7	2016	Further oxidative degradation of intermediates in Co(II)/PMS process yielded brominated disinfection by-products (Br-DBPs) such as bromoform and brominated acetic acids.	Acetates	156-168	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-56
27363023-4	2016	DHA could inhibit proliferation and invasion of breast cancer cells in vitro, and this was mainly through blocking Cox-2-PGE2-NF-kappaB-MMPs cascades.	Docosahexaenoic Acids	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-120
27478470-0	2016	Sulforaphane protects against acrolein-induced oxidative stress and inflammatory responses: modulation of Nrf-2 and COX-2 expression.	sulforaphane	0-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-121
27478470-0	2016	Sulforaphane protects against acrolein-induced oxidative stress and inflammatory responses: modulation of Nrf-2 and COX-2 expression.	Acrolein	30-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-121
27478470-8	2016	Acrolein-induced inflammation was observed through upregulation (p &lt; 0.001) of COX-2 and PGE2 levels.	Acrolein	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
27478470-10	2016	Acrolein-induced inflammation was significantly inhibited through suppression of COX-2 (p &lt; 0.001) and PGE2 levels (p &lt; 0.001).	Acrolein	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-86
27501354-6	2016	This effect disappeared completely in the presence of JTE-013, which is a specific blocker of sphingosine-1-phosphate receptor 2 (S1PR2), as well as in the presence of calphostin and indomethacin, which are inhibitors of protein kinase C (PKC) and COX-2, respectively.	JTE 013	54-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	248-253
27501354-6	2016	This effect disappeared completely in the presence of JTE-013, which is a specific blocker of sphingosine-1-phosphate receptor 2 (S1PR2), as well as in the presence of calphostin and indomethacin, which are inhibitors of protein kinase C (PKC) and COX-2, respectively.	Indomethacin	183-195	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	248-253
27349331-0	2016	Coumarin sulfonamides derivatives as potent and selective COX-2 inhibitors with efficacy in suppressing cancer proliferation and metastasis.	coumarin sulfonamides	0-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
27349331-2	2016	We designed novel series of coumarin sulfonamides derivatives to improve biological activities of COX-2 inhibition and anticancer.	coumarin sulfonamides	28-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-103
31968839-1	2016	By assembling CoII ions and a combination of 5-(4-pyridyl)tetrazole (4-ptz) and formate ions, two distinct metal-organic frameworks, [Co3 (4-ptz)5 (HCOO)(H2 O)2 ] and [Co3 (4-ptz)4 (dmf)2 (HCOO)2 ] (dmf=N,N"-dimethylformamide), were synthesized.	5-(3-pyridyl)tetrazole	134-160	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-18
31968839-1	2016	By assembling CoII ions and a combination of 5-(4-pyridyl)tetrazole (4-ptz) and formate ions, two distinct metal-organic frameworks, [Co3 (4-ptz)5 (HCOO)(H2 O)2 ] and [Co3 (4-ptz)4 (dmf)2 (HCOO)2 ] (dmf=N,N"-dimethylformamide), were synthesized.	2(HCOO)-lysyl-alanyl-alanyl-lysyl-tyrosine-OCH3	148-152	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-18
27312705-5	2016	First, NS-398, instead of reducing inflammation, appeared to further enhance IL-1beta-mediated COX-2 and IL-8 production.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	7-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-100
27578916-9	2016	In the tissue sampled by DBE, apoptotic bodies were found; therefore, it was suggested that the stenoses in this case were caused by the COX-2 inhibitor from the relationship between COX-2 inhibition and apoptosis.	Ethylene Dibromide	25-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-142
27578916-9	2016	In the tissue sampled by DBE, apoptotic bodies were found; therefore, it was suggested that the stenoses in this case were caused by the COX-2 inhibitor from the relationship between COX-2 inhibition and apoptosis.	Ethylene Dibromide	25-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	183-188
30051682-2	2016	Celecoxib is a selective COX-2 inhibitor and has a lower effect of platelet aggregation compared with conventional non-steroidal anti-inflammatory drugs (NSAIDs).	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-30
27115333-0	2016	Nanoscaled zero valent iron/graphene composite as an efficient adsorbent for Co(II) removal from aqueous solution.	Iron	23-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-83
27115333-0	2016	Nanoscaled zero valent iron/graphene composite as an efficient adsorbent for Co(II) removal from aqueous solution.	Graphite	28-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-83
27115333-1	2016	A magnetic graphene, i.e., nanoscaled zero valent iron/graphene (0FG) composite, was prepared, characterized and applied for the removal of Co(II) from aqueous solution.	Graphite	11-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-146
27115333-1	2016	A magnetic graphene, i.e., nanoscaled zero valent iron/graphene (0FG) composite, was prepared, characterized and applied for the removal of Co(II) from aqueous solution.	Iron	50-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-146
27115333-1	2016	A magnetic graphene, i.e., nanoscaled zero valent iron/graphene (0FG) composite, was prepared, characterized and applied for the removal of Co(II) from aqueous solution.	Graphite	55-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-146
27115333-1	2016	A magnetic graphene, i.e., nanoscaled zero valent iron/graphene (0FG) composite, was prepared, characterized and applied for the removal of Co(II) from aqueous solution.	D-Leucyl-N-(4-Fluorobenzyl)-L-Phenylalaninamide	65-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-146
27420328-3	2016	The tandem repeats of the Cysteine-Glycine-Histidine (CGH) metal ion binding motif exhibited concerted binding to Co(II) ions, suggesting that conformational transition of peptide was triggered by the sequential metal ion binding.	cysteine-glycine	26-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-120
27420328-3	2016	The tandem repeats of the Cysteine-Glycine-Histidine (CGH) metal ion binding motif exhibited concerted binding to Co(II) ions, suggesting that conformational transition of peptide was triggered by the sequential metal ion binding.	Histidine	43-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-120
27420328-3	2016	The tandem repeats of the Cysteine-Glycine-Histidine (CGH) metal ion binding motif exhibited concerted binding to Co(II) ions, suggesting that conformational transition of peptide was triggered by the sequential metal ion binding.	Metals	59-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-120
27420328-3	2016	The tandem repeats of the Cysteine-Glycine-Histidine (CGH) metal ion binding motif exhibited concerted binding to Co(II) ions, suggesting that conformational transition of peptide was triggered by the sequential metal ion binding.	Metals	212-217	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-120
27420328-4	2016	Evaluation of the free thiol content after reduction by reducing reagent showed that metal-ion binding elicited strong retardation of cysteine oxidation in the order of Zn(II)&gt;Ni(II)&gt;Co(II).	Sulfhydryl Compounds	23-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	189-195
27420328-4	2016	Evaluation of the free thiol content after reduction by reducing reagent showed that metal-ion binding elicited strong retardation of cysteine oxidation in the order of Zn(II)&gt;Ni(II)&gt;Co(II).	Metals	85-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	189-195
27420328-4	2016	Evaluation of the free thiol content after reduction by reducing reagent showed that metal-ion binding elicited strong retardation of cysteine oxidation in the order of Zn(II)&gt;Ni(II)&gt;Co(II).	Cysteine	134-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	189-195
27420328-4	2016	Evaluation of the free thiol content after reduction by reducing reagent showed that metal-ion binding elicited strong retardation of cysteine oxidation in the order of Zn(II)&gt;Ni(II)&gt;Co(II).	Zinc	169-175	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	189-195
27420328-4	2016	Evaluation of the free thiol content after reduction by reducing reagent showed that metal-ion binding elicited strong retardation of cysteine oxidation in the order of Zn(II)&gt;Ni(II)&gt;Co(II).	Nickel(2+)	179-185	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	189-195
27384529-6	2016	Our data support binding of a serine residue from the reductive-activator protein (RACo) of CoFeSP to the cobalt ion in the CoFeSP-RACo protein complex that stabilizes Co(II).	Serine	30-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	168-174
27384529-6	2016	Our data support binding of a serine residue from the reductive-activator protein (RACo) of CoFeSP to the cobalt ion in the CoFeSP-RACo protein complex that stabilizes Co(II).	Cobalt	106-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	168-174
26985874-3	2016	The initial electrolysis results revealed a change in the oxidation reduction potential (ORP) of [Co(II)(OH)4](2-) (Co(II)) from -267 mV to -800 mV on anodized Ti during electrolytic reduction identifies low-valent homogeneous [Co(I)(OH)4](3-)(Co(I)) formation in 10 M NaOH.	Sodium Hydroxide	269-273	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-104
26985874-3	2016	The initial electrolysis results revealed a change in the oxidation reduction potential (ORP) of [Co(II)(OH)4](2-) (Co(II)) from -267 mV to -800 mV on anodized Ti during electrolytic reduction identifies low-valent homogeneous [Co(I)(OH)4](3-)(Co(I)) formation in 10 M NaOH.	Sodium Hydroxide	269-273	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-122
26985874-4	2016	Cyclic voltammetry analysis of Co(II) at different anodized electrodes, Ag, carbon and Ti, in a 10 M NaOH solution, showed no stripping like peak in the reverse scan only the Ti electrode, supporting the formation of low-valent Co(I).	Sodium Hydroxide	101-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-37
27299178-6	2016	SMM properties for the Co(II) and Mn(III) systems can be rationalized due to the presence of low-energy excitations in the case of Co(II), which are much higher in energy in the case of Mn(III).	manganese(III) acetate dihydrate	34-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-137
27299178-6	2016	SMM properties for the Co(II) and Mn(III) systems can be rationalized due to the presence of low-energy excitations in the case of Co(II), which are much higher in energy in the case of Mn(III).	manganese(III) acetate dihydrate	186-193	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-29
27299178-6	2016	SMM properties for the Co(II) and Mn(III) systems can be rationalized due to the presence of low-energy excitations in the case of Co(II), which are much higher in energy in the case of Mn(III).	manganese(III) acetate dihydrate	186-193	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-137
27305969-0	2016	Effect of ligand denticity on the nitric oxide reactivity of cobalt(ii) complexes.	Nitric Oxide	34-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-70
27328206-1	2016	A long and highly flexible internally functionalized dipyridyl ligand alpha,alpha"-p-xylylenebis(1-(4-pyridylmethylene)-piper-4-azine), L, has been employed in the synthesis of a series of coordination polymer materials with Co(II), Cd(II), and Ag(I) ions.	2,2'-Dipyridyl	53-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	225-231
27328206-1	2016	A long and highly flexible internally functionalized dipyridyl ligand alpha,alpha"-p-xylylenebis(1-(4-pyridylmethylene)-piper-4-azine), L, has been employed in the synthesis of a series of coordination polymer materials with Co(II), Cd(II), and Ag(I) ions.	alpha,alpha"-p-xylylenebis(1-(4-pyridylmethylene)-piper-4-azine)	70-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	225-231
27177092-11	2016	These findings indicate that cholinergic contractility in the human colon can be decreased by the blockade of COX-2 generated excitatory prostanoids, but major pro-inflammatory cytokines or LPS do not alter the sensitivity or amplitude of this contraction ex vivo.	Prostaglandins	137-148	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-115
27135485-6	2016	Bisulfite-treated DNA was used for methylation testing of RUNX3, COX2, and MINT1.	hydrogen sulfite	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-69
27229514-6	2016	Co(II)-substituted analogs (Co2- and ZnCo) of cdMMP16 were prepared and characterized using several spectroscopic techniques, such as UV-Vis, (1)H NMR, and EXAFS spectroscopies.	N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)-4-((4-fluorobenzyl)oxy)pyridine-2,6-dicarboxamide	28-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
27229514-6	2016	Co(II)-substituted analogs (Co2- and ZnCo) of cdMMP16 were prepared and characterized using several spectroscopic techniques, such as UV-Vis, (1)H NMR, and EXAFS spectroscopies.	znco	37-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
27430377-2	2016	Nevertheless, the precise biological mechanism of how celecoxib, a selective COX-2 inhibitor, regulates the growth and invasion of pancreatic tumors is not completely understood.	Celecoxib	54-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-82
27571070-12	2016	This was supported further by COX2 expression induced by 24-h treatment with 1-NP.	1-nitropyrene	77-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-34
27459105-4	2016	The reaction starts with the reduction of Co(II) to Co(I) through a proton-coupled electron transfer process, with the proton delivered to a Tyr246 anion.	tyr246 anion	141-153	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-48
27459105-6	2016	Subsequently, a one-electron transfer leads to the formation of the Co(II) -Cl product, from which the chloride and the dehalogenated product can be released from the active site.	Chlorides	103-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-74
27582708-7	2016	Therefore, in the present review, we summarize the role of dual-acting molecules (FAAH/TRPV1 and FAAH/COX-2 inhibitors) that interact with endocannabinoid and endovanillinoid systems and act as analgesics by elevating the endogenously produced endocannabinoids and dampening the production of pro-inflammatory prostaglandins.	Endocannabinoids	139-154	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-107
27454286-1	2016	A family of Co(II) complexes supported by the bulky, dianionic bis(pyrrolyl)pyridine pincer ligand pyrr2py [pyrr2py(2-) = 3,5-(t)Bu2-bis(pyrrolyl)pyridine] are reported in this work.	bis(pyrrolyl)pyridine	63-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-18
27454286-1	2016	A family of Co(II) complexes supported by the bulky, dianionic bis(pyrrolyl)pyridine pincer ligand pyrr2py [pyrr2py(2-) = 3,5-(t)Bu2-bis(pyrrolyl)pyridine] are reported in this work.	pyrr2py [pyrr2py(2-)	99-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-18
27454286-1	2016	A family of Co(II) complexes supported by the bulky, dianionic bis(pyrrolyl)pyridine pincer ligand pyrr2py [pyrr2py(2-) = 3,5-(t)Bu2-bis(pyrrolyl)pyridine] are reported in this work.	3,5-(t)bu2-bis(pyrrolyl)pyridine	122-154	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-18
27320443-1	2016	By introducing photoactive fac-tris(2-phenylpyridine)iridium moieties as a ligand backbone to constrain the coordination geometry of cobalt ions, a multifunctional Ir2Co3-type capsule was achieved and showed induced-fit capsule-capsule conversion by cooperative binding one carbonate anion with the equatorial Co(ii) centers.	Tris(2-phenylpyridine)iridium	31-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	310-316
27320443-1	2016	By introducing photoactive fac-tris(2-phenylpyridine)iridium moieties as a ligand backbone to constrain the coordination geometry of cobalt ions, a multifunctional Ir2Co3-type capsule was achieved and showed induced-fit capsule-capsule conversion by cooperative binding one carbonate anion with the equatorial Co(ii) centers.	Cobalt	133-139	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	310-316
27320443-1	2016	By introducing photoactive fac-tris(2-phenylpyridine)iridium moieties as a ligand backbone to constrain the coordination geometry of cobalt ions, a multifunctional Ir2Co3-type capsule was achieved and showed induced-fit capsule-capsule conversion by cooperative binding one carbonate anion with the equatorial Co(ii) centers.	carbonate anion	274-289	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	310-316
27547824-6	2016	Finally, the in vitro results were extrapolated to ex vivo studies by administration of the COX-2 inhibitor, celecoxib, to volunteers, illustrating how this approach can be used to integrate preclinical and clinical studies during drug development.	Celecoxib	109-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-97
27363023-4	2016	DHA could inhibit proliferation and invasion of breast cancer cells in vitro, and this was mainly through blocking Cox-2-PGE2-NF-kappaB-MMPs cascades.	Dinoprostone	121-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-120
27363023-5	2016	DHA treatment significantly decreased Cox-2 and NF-kappaB expression as well as nuclear translocation of NF-kappaB in MDA-MB-231 cells.	Docosahexaenoic Acids	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-43
27435418-1	2016	[Co(II)(dpt)(NCS)2], where dpt = bis(3-aminopropyl)amine, was identified as a pentacoordinate Co(II) compound showing field-induced slow relaxation of magnetization.	diphenylthiosulfinate	8-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	1-7
27435418-1	2016	[Co(II)(dpt)(NCS)2], where dpt = bis(3-aminopropyl)amine, was identified as a pentacoordinate Co(II) compound showing field-induced slow relaxation of magnetization.	diphenylthiosulfinate	8-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-100
27435418-1	2016	[Co(II)(dpt)(NCS)2], where dpt = bis(3-aminopropyl)amine, was identified as a pentacoordinate Co(II) compound showing field-induced slow relaxation of magnetization.	diphenylthiosulfinate	27-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	1-7
27435418-1	2016	[Co(II)(dpt)(NCS)2], where dpt = bis(3-aminopropyl)amine, was identified as a pentacoordinate Co(II) compound showing field-induced slow relaxation of magnetization.	diphenylthiosulfinate	27-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-100
27435418-1	2016	[Co(II)(dpt)(NCS)2], where dpt = bis(3-aminopropyl)amine, was identified as a pentacoordinate Co(II) compound showing field-induced slow relaxation of magnetization.	dipropylenetriame	33-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	1-7
27435418-1	2016	[Co(II)(dpt)(NCS)2], where dpt = bis(3-aminopropyl)amine, was identified as a pentacoordinate Co(II) compound showing field-induced slow relaxation of magnetization.	dipropylenetriame	33-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-100
27440001-2	2016	IGDDC exhibited preferential uptake by COX-2 positive cells both in vitro and ex vivo highlighting indomethacin"s role in designing new cancer-specific drug delivery frameworks.	Indomethacin	99-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-44
27385366-5	2016	Additionally, elevated levels of cyclo-oxygenase 2 (PTGS2; COX-2) and prostaglandin E2 (PGE2) secretion were observed in senescent fibroblasts, and inhibition of COX-2 by celecoxib reduced the expression of miR-335, restored PTEN expression and decreased the pro-tumourigenic effects of the SASP.	Celecoxib	171-180	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	162-167
27177970-0	2016	Identification of the two-phase mechanism of arachidonic acid regulating inflammatory prostaglandin E2 biosynthesis by targeting COX-2 and mPGES-1.	Arachidonic Acid	45-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-134
27177970-0	2016	Identification of the two-phase mechanism of arachidonic acid regulating inflammatory prostaglandin E2 biosynthesis by targeting COX-2 and mPGES-1.	Dinoprostone	86-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-134
27177970-1	2016	Through linking inducible cyclooxygenase (COX)-2 with microsomal prostaglandin E2 (PGE2) synthase-1 (mPGES-1), a Single-Chain Enzyme Complex (SCEC, COX-2-10aa-mPGES-1) was engineered to mimic a specific inflammatory PGE2 biosynthesis from omega-6 fatty acid, arachidonic acid (AA), by eliminating involvements of non-inducible COX-1 and other PGE2 synthases.	Dinoprostone	65-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	148-153
27177970-1	2016	Through linking inducible cyclooxygenase (COX)-2 with microsomal prostaglandin E2 (PGE2) synthase-1 (mPGES-1), a Single-Chain Enzyme Complex (SCEC, COX-2-10aa-mPGES-1) was engineered to mimic a specific inflammatory PGE2 biosynthesis from omega-6 fatty acid, arachidonic acid (AA), by eliminating involvements of non-inducible COX-1 and other PGE2 synthases.	Dinoprostone	83-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	148-153
27177970-2	2016	Using the SCEC, we characterized coupling reactions between COX-2 and mPGES-1 at 1:1 ratio of inflammatory PGE2 production.	Dinoprostone	107-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-65
27267893-2	2016	We investigated the effectiveness of curcumin, a potent inhibitor of NF-kappaB/COX-2, molecules perturbed in oral carcinogenesis, to treat leukoplakia.	Curcumin	37-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-84
27368132-1	2016	Recent research has demonstrated that colon cancer cell proliferation can be suppressed in the cells that overexpress COX-2 via generating 8-hydroxyoctanoic acid (a free radical byproduct) during dihomo-gamma-linolenic acid (DGLA, an omega-6 fatty acid) peroxidation from knocking down cellular delta-5-desaturase (D5D, the key enzyme for converting DGLA to the downstream omega-6, arachidonic acid).	8-hydroxyoctanoic acid	139-161	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-123
27368132-1	2016	Recent research has demonstrated that colon cancer cell proliferation can be suppressed in the cells that overexpress COX-2 via generating 8-hydroxyoctanoic acid (a free radical byproduct) during dihomo-gamma-linolenic acid (DGLA, an omega-6 fatty acid) peroxidation from knocking down cellular delta-5-desaturase (D5D, the key enzyme for converting DGLA to the downstream omega-6, arachidonic acid).	alpha-Linolenic Acid	208-223	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-123
27368132-1	2016	Recent research has demonstrated that colon cancer cell proliferation can be suppressed in the cells that overexpress COX-2 via generating 8-hydroxyoctanoic acid (a free radical byproduct) during dihomo-gamma-linolenic acid (DGLA, an omega-6 fatty acid) peroxidation from knocking down cellular delta-5-desaturase (D5D, the key enzyme for converting DGLA to the downstream omega-6, arachidonic acid).	8,11,14-Eicosatrienoic Acid	225-229	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-123
27368132-1	2016	Recent research has demonstrated that colon cancer cell proliferation can be suppressed in the cells that overexpress COX-2 via generating 8-hydroxyoctanoic acid (a free radical byproduct) during dihomo-gamma-linolenic acid (DGLA, an omega-6 fatty acid) peroxidation from knocking down cellular delta-5-desaturase (D5D, the key enzyme for converting DGLA to the downstream omega-6, arachidonic acid).	Fatty Acids, Omega-6	234-252	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-123
27368132-1	2016	Recent research has demonstrated that colon cancer cell proliferation can be suppressed in the cells that overexpress COX-2 via generating 8-hydroxyoctanoic acid (a free radical byproduct) during dihomo-gamma-linolenic acid (DGLA, an omega-6 fatty acid) peroxidation from knocking down cellular delta-5-desaturase (D5D, the key enzyme for converting DGLA to the downstream omega-6, arachidonic acid).	8,11,14-Eicosatrienoic Acid	350-354	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-123
27368132-1	2016	Recent research has demonstrated that colon cancer cell proliferation can be suppressed in the cells that overexpress COX-2 via generating 8-hydroxyoctanoic acid (a free radical byproduct) during dihomo-gamma-linolenic acid (DGLA, an omega-6 fatty acid) peroxidation from knocking down cellular delta-5-desaturase (D5D, the key enzyme for converting DGLA to the downstream omega-6, arachidonic acid).	omega-6	234-241	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-123
27368132-1	2016	Recent research has demonstrated that colon cancer cell proliferation can be suppressed in the cells that overexpress COX-2 via generating 8-hydroxyoctanoic acid (a free radical byproduct) during dihomo-gamma-linolenic acid (DGLA, an omega-6 fatty acid) peroxidation from knocking down cellular delta-5-desaturase (D5D, the key enzyme for converting DGLA to the downstream omega-6, arachidonic acid).	Arachidonic Acid	382-398	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-123
27368132-3	2016	The pancreatic cancer cell line, BxPC-3 (with high COX-2 expression and mutated p53), was used to assess not only the inhibitory effects of the enhanced formation of 8-hydroxyoctanoic acid from cellular COX-2-catalyzed DGLA peroxidation but also its potential synergistic and/or additive effect on current chemotherapy drugs.	8-hydroxyoctanoic acid	166-188	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	203-208
27368132-7	2016	Based on the COX-2 metabolic cascade, the outcomes presented here could guide the development of a novel omega-6-based dietary care strategy in combination with chemotherapy for pancreatic cancer.	omega-6	105-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
27375229-12	2016	In vivo, Co(0) in complexes was oxidised to Co(II).	co(0)	9-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-50
27312705-3	2016	NS-398 is a selective inhibitor of COX-2 bioactivity and thus this drug is able to mitigate the COX-2-mediated production of downstream prostaglandins and the subsequent inflammatory response.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	0-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40
27312705-3	2016	NS-398 is a selective inhibitor of COX-2 bioactivity and thus this drug is able to mitigate the COX-2-mediated production of downstream prostaglandins and the subsequent inflammatory response.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	0-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-101
27312705-3	2016	NS-398 is a selective inhibitor of COX-2 bioactivity and thus this drug is able to mitigate the COX-2-mediated production of downstream prostaglandins and the subsequent inflammatory response.	Prostaglandins	136-150	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40
27312705-3	2016	NS-398 is a selective inhibitor of COX-2 bioactivity and thus this drug is able to mitigate the COX-2-mediated production of downstream prostaglandins and the subsequent inflammatory response.	Prostaglandins	136-150	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-101
27372846-3	2016	COX-2(-/-) animal models showed the dependence of osseointegration on prostaglandins.	Prostaglandins	70-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
27372846-4	2016	PGE2, a product of COX-2, augments Wnt signalling, a pathway that promotes the regeneration in many types of tissues.	Dinoprostone	0-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-24
27007068-0	2016	Evidence for a central mode of action for etoricoxib (COX-2 inhibitor) in patients with painful knee osteoarthritis.	Etoricoxib	42-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-59
27007068-1	2016	The COX-2 inhibitor etoricoxib modulates the peripheral and central nociceptive mechanisms in animals.	Etoricoxib	20-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
27489545-1	2016	In subjects with non-steroidal anti-inflammatory drugs (NSAIDs)- exacerbated respiratory disease (NERD) symptoms are triggered by acetyl salicylic acid (ASA) and other strong COX-1 inhibitors, and in some cases by weak COX-1 or by selective COX-2 inhibitors.	Aspirin	153-156	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	241-246
27037477-0	2016	The impact of functionalized CNT in the network of sodium alginate-based nanocomposite beads on the removal of Co(II) ions from aqueous solutions.	Alginates	51-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	111-117
27259813-10	2016	SIGNIFICANCE: These findings indicate that celecoxib enhances the degranulation of CD8(+) T cells on HPV16-induced lesions, suggesting the potential clinical use of COX-2 inhibitors.	Celecoxib	43-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	165-170
27356282-0	2016	Co(II) PCP Pincer Complexes as Catalysts for the Alkylation of Aromatic Amines with Primary Alcohols.	aromatic amines	63-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
27356282-0	2016	Co(II) PCP Pincer Complexes as Catalysts for the Alkylation of Aromatic Amines with Primary Alcohols.	Alcohols	92-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
27356282-1	2016	Efficient alkylations of amines by alcohols catalyzed by well-defined Co(II) complexes are described that are stabilized by a PCP ligand (N,N"-bis(diisopropylphosphino)-N,N"-dimethyl-1,3-diaminobenzene) based on the 1,3-diaminobenzene scaffold.	Amines	25-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-76
27356282-1	2016	Efficient alkylations of amines by alcohols catalyzed by well-defined Co(II) complexes are described that are stabilized by a PCP ligand (N,N"-bis(diisopropylphosphino)-N,N"-dimethyl-1,3-diaminobenzene) based on the 1,3-diaminobenzene scaffold.	Alcohols	35-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-76
27356282-1	2016	Efficient alkylations of amines by alcohols catalyzed by well-defined Co(II) complexes are described that are stabilized by a PCP ligand (N,N"-bis(diisopropylphosphino)-N,N"-dimethyl-1,3-diaminobenzene) based on the 1,3-diaminobenzene scaffold.	pcp	126-129	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-76
27356282-1	2016	Efficient alkylations of amines by alcohols catalyzed by well-defined Co(II) complexes are described that are stabilized by a PCP ligand (N,N"-bis(diisopropylphosphino)-N,N"-dimethyl-1,3-diaminobenzene) based on the 1,3-diaminobenzene scaffold.	n,n"-bis(diisopropylphosphino)-n,n"-dimethyl-1,3-diaminobenzene	138-201	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-76
27356282-1	2016	Efficient alkylations of amines by alcohols catalyzed by well-defined Co(II) complexes are described that are stabilized by a PCP ligand (N,N"-bis(diisopropylphosphino)-N,N"-dimethyl-1,3-diaminobenzene) based on the 1,3-diaminobenzene scaffold.	3-phenylenediamine	183-201	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-76
27312695-3	2016	Previously, we had validated the corresponding Co(II) complexes as synthetic model systems for dioxygen-binding heme proteins and demonstrated the structural requirements for proper distal H-bonding to Co(II) -bound dioxygen.	Oxygen	95-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-53
27312695-3	2016	Previously, we had validated the corresponding Co(II) complexes as synthetic model systems for dioxygen-binding heme proteins and demonstrated the structural requirements for proper distal H-bonding to Co(II) -bound dioxygen.	Oxygen	95-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	202-208
27312695-3	2016	Previously, we had validated the corresponding Co(II) complexes as synthetic model systems for dioxygen-binding heme proteins and demonstrated the structural requirements for proper distal H-bonding to Co(II) -bound dioxygen.	Oxygen	216-224	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-53
27312695-3	2016	Previously, we had validated the corresponding Co(II) complexes as synthetic model systems for dioxygen-binding heme proteins and demonstrated the structural requirements for proper distal H-bonding to Co(II) -bound dioxygen.	Oxygen	216-224	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	202-208
27312695-5	2016	The H-bond in the dioxygen adducts of the Co(II) porphyrins was directly measured by Q-band Davies-ENDOR spectroscopy.	Oxygen	18-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-48
27300721-2	2016	We report that a combination of variable scan rate cyclic voltammetry and foot-of-the-wave analysis (FOWA) can be used to detect transient Co(III)H and Co(II)H intermediates of electrocatalytic H2 production by [Co(II)(P(tBu)2N(Ph)2)(CH3CN)3](2+) and Co(II)(dmgBF2)2(CH3CN)2.	co(iii)h	139-147	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	212-218
27300721-2	2016	We report that a combination of variable scan rate cyclic voltammetry and foot-of-the-wave analysis (FOWA) can be used to detect transient Co(III)H and Co(II)H intermediates of electrocatalytic H2 production by [Co(II)(P(tBu)2N(Ph)2)(CH3CN)3](2+) and Co(II)(dmgBF2)2(CH3CN)2.	co(iii)h	139-147	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	212-218
27300721-2	2016	We report that a combination of variable scan rate cyclic voltammetry and foot-of-the-wave analysis (FOWA) can be used to detect transient Co(III)H and Co(II)H intermediates of electrocatalytic H2 production by [Co(II)(P(tBu)2N(Ph)2)(CH3CN)3](2+) and Co(II)(dmgBF2)2(CH3CN)2.	Cobalt(2+)	152-158	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	212-218
27300721-2	2016	We report that a combination of variable scan rate cyclic voltammetry and foot-of-the-wave analysis (FOWA) can be used to detect transient Co(III)H and Co(II)H intermediates of electrocatalytic H2 production by [Co(II)(P(tBu)2N(Ph)2)(CH3CN)3](2+) and Co(II)(dmgBF2)2(CH3CN)2.	Cobalt(2+)	152-158	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	212-218
27300721-2	2016	We report that a combination of variable scan rate cyclic voltammetry and foot-of-the-wave analysis (FOWA) can be used to detect transient Co(III)H and Co(II)H intermediates of electrocatalytic H2 production by [Co(II)(P(tBu)2N(Ph)2)(CH3CN)3](2+) and Co(II)(dmgBF2)2(CH3CN)2.	Hydrogen	194-196	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	212-218
27300721-2	2016	We report that a combination of variable scan rate cyclic voltammetry and foot-of-the-wave analysis (FOWA) can be used to detect transient Co(III)H and Co(II)H intermediates of electrocatalytic H2 production by [Co(II)(P(tBu)2N(Ph)2)(CH3CN)3](2+) and Co(II)(dmgBF2)2(CH3CN)2.	Hydrogen	194-196	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	212-218
27300721-2	2016	We report that a combination of variable scan rate cyclic voltammetry and foot-of-the-wave analysis (FOWA) can be used to detect transient Co(III)H and Co(II)H intermediates of electrocatalytic H2 production by [Co(II)(P(tBu)2N(Ph)2)(CH3CN)3](2+) and Co(II)(dmgBF2)2(CH3CN)2.	tbu)2n	221-227	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	212-218
27300721-2	2016	We report that a combination of variable scan rate cyclic voltammetry and foot-of-the-wave analysis (FOWA) can be used to detect transient Co(III)H and Co(II)H intermediates of electrocatalytic H2 production by [Co(II)(P(tBu)2N(Ph)2)(CH3CN)3](2+) and Co(II)(dmgBF2)2(CH3CN)2.	tbu)2n	221-227	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	212-218
27300721-2	2016	We report that a combination of variable scan rate cyclic voltammetry and foot-of-the-wave analysis (FOWA) can be used to detect transient Co(III)H and Co(II)H intermediates of electrocatalytic H2 production by [Co(II)(P(tBu)2N(Ph)2)(CH3CN)3](2+) and Co(II)(dmgBF2)2(CH3CN)2.	dmgbf2	258-264	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	212-218
27300721-2	2016	We report that a combination of variable scan rate cyclic voltammetry and foot-of-the-wave analysis (FOWA) can be used to detect transient Co(III)H and Co(II)H intermediates of electrocatalytic H2 production by [Co(II)(P(tBu)2N(Ph)2)(CH3CN)3](2+) and Co(II)(dmgBF2)2(CH3CN)2.	dmgbf2	258-264	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	212-218
27300721-5	2016	A bridge-protonated Co(I) species was ruled out as a catalytic intermediate for Co(II)(dmgBF2)2(CH3CN)2 from voltammograms recorded at 1000 psi of H2.	NAD	20-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-86
27300721-5	2016	A bridge-protonated Co(I) species was ruled out as a catalytic intermediate for Co(II)(dmgBF2)2(CH3CN)2 from voltammograms recorded at 1000 psi of H2.	Hydrogen	147-149	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-86
27301436-0	2016	Carving a 1D Co(II)-carboranylcarboxylate system by using organic solvents to create stable trinuclear molecular analogues: complete structural and magnetic studies.	trinuclear	92-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-19
27301436-1	2016	This work presents a straightforward methodology to achieve small linear trinuclear molecules based on the Co(II)-carboranylcarboxylate system obtained by carving a 1D polynuclear analogous system with the use of diethylether.	carboranylcarboxylate	114-135	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-113
27301436-5	2016	X-ray analysis of and revealed that presents a dinuclear structure whereas is trinuclear; in both cases a six-coordinated Co(II) compound with water molecules bridging each of the two Co(II) centres has been observed.	Water	143-148	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-128
27301436-5	2016	X-ray analysis of and revealed that presents a dinuclear structure whereas is trinuclear; in both cases a six-coordinated Co(II) compound with water molecules bridging each of the two Co(II) centres has been observed.	Water	143-148	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	184-190
27301436-6	2016	The magnetic properties of and show a weak antiferromagnetic behaviour, respectively, between the Co(II) centres mediated by two carboxylate ligands and a molecule of water.	carboxylate	129-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-104
27301436-6	2016	The magnetic properties of and show a weak antiferromagnetic behaviour, respectively, between the Co(II) centres mediated by two carboxylate ligands and a molecule of water.	Water	167-172	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-104
27177092-3	2016	While colitis is associated with upregulated COX-2 -derived prostanoids and nitric oxide (NO), the direct activity of pro-inflammatory cytokines on human colonic neuromuscular function is less clear.	Prostaglandins	60-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-50
27177092-8	2016	None of the cytokine or LPS explant incubations affected the potency or maximum cholinergic contraction in vitro, and subsequent COX-2 blockade with nimesulide revealed a significant but similar decrease in potency of ACh-evoked contraction in control, LPS and cytokine-incubated muscle strips.	nimesulide	149-159	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-134
27247213-3	2016	The proposed sorbent is obtained due to the surfactant-assisted self-assembly of Co(II)/imidazolate PCPs on commercially available melamine foam, followed by the in situ conversion of the PCP into the final dissolvable LDH coating.	melamine foam	131-144	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-87
27161844-0	2016	Steroid receptor co-activator interacting protein (SIP) mediates EGF-stimulated expression of the prostaglandin synthase COX2 and prostaglandin release in human myometrium.	Prostaglandins	98-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-125
27088506-0	2016	Some new nano-sized Cr(III), Fe(II), Co(II), and Ni(II) complexes incorporating 2-((E)-(pyridine-2-ylimino)methyl)napthalen-1-ol ligand: Structural characterization, electrochemical, antioxidant, antimicrobial, antiviral assessment and DNA interaction.	2-((e)-(pyridine-2-ylimino)methyl)napthalen-1-ol	80-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-43
27088506-1	2016	To estimate the biological preference of synthetic small drugs towards DNA target, new metal based chemotherapeutic agents of nano-sized Cr(III), Fe(II), Co(II) and Ni(II) Schiff base complexes having N,N,O donor system were synthesized and thoroughly characterized by physic-chemical techniques.	Metals	87-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	154-160
27088506-2	2016	The redox behavior of the Cr(III), Fe(II) and Co(II) complex was investigated by electrochemical method using cyclic voltammetry.	tris(1,10-phenanthroline)chromium(III) chloride	26-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-52
27428192-2	2016	Parecoxib, a selective cyclooxygenase (COX)-2 inhibitor, is used for postoperative analgesia for its potent anti-inflammatory and analgesic effects.	parecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-45
27111555-1	2016	Biosynthesis of prostaglandins from arachidonic acid (AA) is catalyzed by cyclooxygenase (COX), which exists as COX-1 and COX-2.	Prostaglandins	16-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-127
27111555-1	2016	Biosynthesis of prostaglandins from arachidonic acid (AA) is catalyzed by cyclooxygenase (COX), which exists as COX-1 and COX-2.	Arachidonic Acid	36-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-127
27161844-1	2016	STUDY HYPOTHESIS: Steroid receptor coactivator interacting protein (SIP/KANK2) is involved in regulating the expression of the prostaglandin (PG)-endoperoxide synthase 2 (PTGS2; also known as cyclo-oxygenase 2, COX2) and PG release in human myometrium.	Prostaglandins	127-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	211-215
27161844-1	2016	STUDY HYPOTHESIS: Steroid receptor coactivator interacting protein (SIP/KANK2) is involved in regulating the expression of the prostaglandin (PG)-endoperoxide synthase 2 (PTGS2; also known as cyclo-oxygenase 2, COX2) and PG release in human myometrium.	Prostaglandins	142-144	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	211-215
27161844-4	2016	A key mediator of uterine PG production is the highly inducible enzyme COX2.	Prostaglandins	26-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-75
26995677-4	2016	Here we identified that of the five primary prostanoids produced by COX-1/COX-2, only PGD2 displayed significant repressor activity.	Prostaglandins	44-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
27376271-8	2016	Furthermore, AL7 also modulated the expression of COX-2, IL-1beta and TNF-alpha in these cell lines, suggesting anti-inflammatory activity.	AL7099A	13-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-55
27273116-6	2016	While maintains near-TP configurations in the presence of metal ions with strong octahedral preferences, distorts towards predominantly octahedral co-ordination geometries, increasing in the order Co(II) &lt; Ni(II) &lt; Fe(II) and no trigonal prismatic structures.	Metals	58-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	197-203
27273116-6	2016	While maintains near-TP configurations in the presence of metal ions with strong octahedral preferences, distorts towards predominantly octahedral co-ordination geometries, increasing in the order Co(II) &lt; Ni(II) &lt; Fe(II) and no trigonal prismatic structures.	Nickel(2+)	209-215	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	197-203
27273116-6	2016	While maintains near-TP configurations in the presence of metal ions with strong octahedral preferences, distorts towards predominantly octahedral co-ordination geometries, increasing in the order Co(II) &lt; Ni(II) &lt; Fe(II) and no trigonal prismatic structures.	ammonium ferrous sulfate	221-227	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	197-203
27367692-2	2016	Based on a selectivity study, the SG-APTMS-N,N-EPANTf2 phase showed a perfect selectivity towards Zr(IV) at pH 4 as compared to other metallic ions, including gold [Au(III)], copper [Cu(II)], cobalt [Co(II)], chromium [Cr(III)], lead [Pb(II)], selenium [Se(IV)] and mercury [Hg(II)] ions.	Nitrogen	43-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	200-207
27302622-0	2016	Co(ii)-induced giant vibrational CD provides a new design of methods for rapid and sensitive chirality recognition.	Cadmium	33-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
27227459-6	2016	MG also impaired zymosan-stimulated macrophages by inhibiting IL-6 and NO production, COX-2 and iNOS expression, and intracellular calcium mobilization.	Zymosan	17-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-91
27167594-1	2016	Under H2 pressure, Co(II)(dmgBF2)2L2 (L = H2O, THF) generates a low concentration of an H  donor.	Hydrogen	6-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-36
27167594-1	2016	Under H2 pressure, Co(II)(dmgBF2)2L2 (L = H2O, THF) generates a low concentration of an H  donor.	Water	42-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-36
27167594-1	2016	Under H2 pressure, Co(II)(dmgBF2)2L2 (L = H2O, THF) generates a low concentration of an H  donor.	tetrahydrofuran	47-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-36
27251465-3	2016	Further, the gram scale synthesis of a COX-2 inhibitor (3-(pyridin-2-ylthio)-1H-indole), regioselectivity and recyclability (up to four cycles) are the additional merits of this cooperative cascade bio-chemocatalytic (BSA-I2) protocol.	3-(pyridin-2-ylthio)-1h-indole	56-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-44
27151823-0	2016	Single-ion magnet behaviour in mononuclear and two-dimensional dicyanamide-containing cobalt(ii) complexes.	trimethylsulfonium dicyanamide	63-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-95
27230103-1	2016	A series of Ni(II), Co(II), Zn(II) and Cd(II) complexes with polytopic Schiff base ligands have been synthesized.	Schiff Bases	71-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-26
27151823-2	2016	Compound is a mononuclear species where the cobalt(ii) ion is six-coordinate with four bim molecules in the equatorial positions [Co-Nbim = 2.1546(15) and 2.1489(15) A] and two trans-positioned dca ligands [Co-Ndca = 2.1575(18) A] in the axial sites of a somewhat distorted octahedral surrounding.	co-nbim	130-137	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-53
27151823-2	2016	Compound is a mononuclear species where the cobalt(ii) ion is six-coordinate with four bim molecules in the equatorial positions [Co-Nbim = 2.1546(15) and 2.1489(15) A] and two trans-positioned dca ligands [Co-Ndca = 2.1575(18) A] in the axial sites of a somewhat distorted octahedral surrounding.	Dichloroacetic Acid	194-197	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-53
27151823-2	2016	Compound is a mononuclear species where the cobalt(ii) ion is six-coordinate with four bim molecules in the equatorial positions [Co-Nbim = 2.1546(15) and 2.1489(15) A] and two trans-positioned dca ligands [Co-Ndca = 2.1575(18) A] in the axial sites of a somewhat distorted octahedral surrounding.	co-ndca	207-214	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-53
27243450-1	2016	The ionic liquid trihexyl(tetradecyl)phosphonium thiocyanate has been used for the extraction of the transition metal ions Co(ii), Ni(ii), Zn(ii), and the rare-earth ions La(iii), Sm(iii) and Eu(iii) from aqueous solutions containing nitrate or chloride salts.	SCHEMBL3782995	17-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-128
27151823-3	2016	The structures of and consist of two-dimensional grids of cobalt(ii) ions where each metal atom is linked to the other four metal centres by single dca bridges exhibiting the mu1,5-dca coordination mode [Co-Ndca = 2.190(3)-2.220(3) () and 2.127(3)-2.153(3) A ()].	Metals	85-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-67
27151823-3	2016	The structures of and consist of two-dimensional grids of cobalt(ii) ions where each metal atom is linked to the other four metal centres by single dca bridges exhibiting the mu1,5-dca coordination mode [Co-Ndca = 2.190(3)-2.220(3) () and 2.127(3)-2.153(3) A ()].	Metals	124-129	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-67
27151823-3	2016	The structures of and consist of two-dimensional grids of cobalt(ii) ions where each metal atom is linked to the other four metal centres by single dca bridges exhibiting the mu1,5-dca coordination mode [Co-Ndca = 2.190(3)-2.220(3) () and 2.127(3)-2.153(3) A ()].	Dichloroacetic Acid	148-151	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-67
27151823-3	2016	The structures of and consist of two-dimensional grids of cobalt(ii) ions where each metal atom is linked to the other four metal centres by single dca bridges exhibiting the mu1,5-dca coordination mode [Co-Ndca = 2.190(3)-2.220(3) () and 2.127(3)-2.153(3) A ()].	co-ndca	204-211	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-67
27151823-4	2016	Two trans-coordinated bim ()/bmim () molecules achieve the six-coordination around each cobalt(ii) ion [Co-Nbim = 2.128(3)-2.134(4) A () and Co-Nbmim = 2.156(3)-2.163(39) A ()].	co-nbim	104-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-97
27151823-4	2016	Two trans-coordinated bim ()/bmim () molecules achieve the six-coordination around each cobalt(ii) ion [Co-Nbim = 2.128(3)-2.134(4) A () and Co-Nbmim = 2.156(3)-2.163(39) A ()].	co-nbmim	141-149	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-97
27243450-1	2016	The ionic liquid trihexyl(tetradecyl)phosphonium thiocyanate has been used for the extraction of the transition metal ions Co(ii), Ni(ii), Zn(ii), and the rare-earth ions La(iii), Sm(iii) and Eu(iii) from aqueous solutions containing nitrate or chloride salts.	SCHEMBL3782995	17-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-129
27243450-1	2016	The ionic liquid trihexyl(tetradecyl)phosphonium thiocyanate has been used for the extraction of the transition metal ions Co(ii), Ni(ii), Zn(ii), and the rare-earth ions La(iii), Sm(iii) and Eu(iii) from aqueous solutions containing nitrate or chloride salts.	SCHEMBL3782995	17-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-136
27243450-1	2016	The ionic liquid trihexyl(tetradecyl)phosphonium thiocyanate has been used for the extraction of the transition metal ions Co(ii), Ni(ii), Zn(ii), and the rare-earth ions La(iii), Sm(iii) and Eu(iii) from aqueous solutions containing nitrate or chloride salts.	Metals	112-117	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-129
27243450-1	2016	The ionic liquid trihexyl(tetradecyl)phosphonium thiocyanate has been used for the extraction of the transition metal ions Co(ii), Ni(ii), Zn(ii), and the rare-earth ions La(iii), Sm(iii) and Eu(iii) from aqueous solutions containing nitrate or chloride salts.	Metals	112-117	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-128
27243450-1	2016	The ionic liquid trihexyl(tetradecyl)phosphonium thiocyanate has been used for the extraction of the transition metal ions Co(ii), Ni(ii), Zn(ii), and the rare-earth ions La(iii), Sm(iii) and Eu(iii) from aqueous solutions containing nitrate or chloride salts.	Metals	112-117	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-136
27243450-6	2016	Close to 100% loading was possible for Co(ii) and Zn(ii) up to a concentration of 40 g L(-1) of the transition metal salt in the initial aqueous feed solution, whereas the extraction efficiency for Ni(ii) gradually decreased with increase in the initial feed concentration.	metal salt	111-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-45
27243450-6	2016	Close to 100% loading was possible for Co(ii) and Zn(ii) up to a concentration of 40 g L(-1) of the transition metal salt in the initial aqueous feed solution, whereas the extraction efficiency for Ni(ii) gradually decreased with increase in the initial feed concentration.	metal salt	111-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-44
27243450-6	2016	Close to 100% loading was possible for Co(ii) and Zn(ii) up to a concentration of 40 g L(-1) of the transition metal salt in the initial aqueous feed solution, whereas the extraction efficiency for Ni(ii) gradually decreased with increase in the initial feed concentration.	metal salt	111-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-55
27243450-7	2016	Stripping of Co(ii), Zn(ii) and Ni(ii) from the loaded ionic liquid phase was possible by a 15 wt% NH3 solution.	Ammonia	99-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-19
27243450-7	2016	Stripping of Co(ii), Zn(ii) and Ni(ii) from the loaded ionic liquid phase was possible by a 15 wt% NH3 solution.	Ammonia	99-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-18
27243450-7	2016	Stripping of Co(ii), Zn(ii) and Ni(ii) from the loaded ionic liquid phase was possible by a 15 wt% NH3 solution.	Ammonia	99-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-26
27216189-4	2016	We found that YAP function is required for NF2-null Schwann cell survival, proliferation, and tumor growth in vivo Moreover, YAP promotes transcription of several targets including PTGS2, which codes for COX-2, a key enzyme in prostaglandin biosynthesis, and AREG, which codes for the EGFR ligand, amphiregulin.	Prostaglandins	227-240	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	204-209
27386557-1	2016	Metal-free carbon-based electrocatalysts for dye-sensitized solar cells (DSSCs) are sufficiently active in Co(II)/Co(III) electrolytes but are not satisfactory in the most commonly used iodide/triiodide (I(-)/I3 (-)) electrolytes.	Metals	0-5	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-113
27386557-1	2016	Metal-free carbon-based electrocatalysts for dye-sensitized solar cells (DSSCs) are sufficiently active in Co(II)/Co(III) electrolytes but are not satisfactory in the most commonly used iodide/triiodide (I(-)/I3 (-)) electrolytes.	Carbon	11-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-113
27386557-3	2016	We report the synthesis of edge-selenated graphene nanoplatelets (SeGnPs) prepared by a simple mechanochemical reaction between graphite and selenium (Se) powders, and their application to the counter electrode (CE) for DSSCs in both I(-)/I3 (-) and Co(II)/Co(III) electrolytes.	Graphite	42-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	250-256
27386557-3	2016	We report the synthesis of edge-selenated graphene nanoplatelets (SeGnPs) prepared by a simple mechanochemical reaction between graphite and selenium (Se) powders, and their application to the counter electrode (CE) for DSSCs in both I(-)/I3 (-) and Co(II)/Co(III) electrolytes.	segnps	66-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	250-256
27386557-3	2016	We report the synthesis of edge-selenated graphene nanoplatelets (SeGnPs) prepared by a simple mechanochemical reaction between graphite and selenium (Se) powders, and their application to the counter electrode (CE) for DSSCs in both I(-)/I3 (-) and Co(II)/Co(III) electrolytes.	Selenium	66-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	250-256
27074576-1	2016	Our objective was to evaluate the effect of the COX-2 inhibitor, celecoxib, on (1) proliferation and apoptosis in human ovarian cancer cell lines and primary cultures of ovarian cancer cells, and (2) inhibition of tumor growth in a genetically engineered mouse model of serous ovarian cancer under obese and non-obese conditions.	Celecoxib	65-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-53
27158139-1	2016	Two new series of 1,5-diaryl pyrazoline (3a-f) and 1,5-diaryl pyrazole (5a and 5b) were designed as both COX-2 and 15-LOX inhibitors.	1,5-diaryl pyrazoline	18-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-110
27158139-1	2016	Two new series of 1,5-diaryl pyrazoline (3a-f) and 1,5-diaryl pyrazole (5a and 5b) were designed as both COX-2 and 15-LOX inhibitors.	1,5-diaryl pyrazole	51-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-110
27020655-1	2016	To explore the epigenetic mechanisms underlying the effects of anti-Helicobacter pylori (H. pylori) alone and combined with COX-2 inhibitor (celecoxib), we dynamically evaluated the associations between COX-2 methylation alterations and gastric lesion evolution during the process of interventions.	Celecoxib	141-150	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	124-129
27158139-4	2016	Pyrazoline 3f is the most effective with IC50=1.14 and 4.7muM against COX-2 and 15-LOX respectively, and more potent than celecoxib and meclofenamate references.	pyrazoline	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-75
27235710-14	2016	Furthermore, the results of qRT-PCR showed that lupeol pre-treatment significantly (p&lt;0.05) decreased mancozeb-induced expression of DNA damage (p53, MDM2, COX-2, GADD45alpha and p21) and increased expression of DNA repair responsive genes (hOGG1 and XRCC1) in CHLs.	mancozeb	105-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	159-164
27153549-2	2016	MATERIALS AND METHODS: Immunohistochemistry assay was used to detect expression of APAF-1 and COX-2 in paraffin-wax embedded tissues obtained before neo-CRT for patients with RAC.	Paraffin	103-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-99
27253400-0	2016	Finasteride Enhances the Generation of Human Myeloid-Derived Suppressor Cells by Up-Regulating the COX2/PGE2 Pathway.	Finasteride	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-103
27253400-7	2016	Next, we aimed to determine the mechanism of action of FIN and found that FIN induced the expansion of MDSCs through up-regulation of the COX2/PGE2 pathway by enhancing the activity of COX2 promoter.	Dinoprostone	143-147	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	138-142
27253400-7	2016	Next, we aimed to determine the mechanism of action of FIN and found that FIN induced the expansion of MDSCs through up-regulation of the COX2/PGE2 pathway by enhancing the activity of COX2 promoter.	Dinoprostone	143-147	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	185-189
27253400-8	2016	In addition, the administration of indomethacin (IND), a COX2 inhibitor, abrogated the effect of FIN.	Indomethacin	35-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-61
27253400-8	2016	In addition, the administration of indomethacin (IND), a COX2 inhibitor, abrogated the effect of FIN.	Indomethacin	49-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-61
27020655-1	2016	To explore the epigenetic mechanisms underlying the effects of anti-Helicobacter pylori (H. pylori) alone and combined with COX-2 inhibitor (celecoxib), we dynamically evaluated the associations between COX-2 methylation alterations and gastric lesion evolution during the process of interventions.	Celecoxib	141-150	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	203-208
27020655-4	2016	With placebo group as reference, COX-2 methylation levels were decreased in anti-H. pylori [OR, 3.30; 95% confidence interval (CI), 2.16-5.02], celecoxib (OR, 2.04; 95% CI, 1.36-3.07), and anti-H. pylori followed by celecoxib (OR, 2.10; 95% CI, 1.38-3.17) groups.	Celecoxib	144-153	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-38
27020655-4	2016	With placebo group as reference, COX-2 methylation levels were decreased in anti-H. pylori [OR, 3.30; 95% confidence interval (CI), 2.16-5.02], celecoxib (OR, 2.04; 95% CI, 1.36-3.07), and anti-H. pylori followed by celecoxib (OR, 2.10; 95% CI, 1.38-3.17) groups.	Celecoxib	216-225	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-38
27020655-5	2016	When stratified by baseline histology, the three active arms significantly decreased COX-2 methylation levels in indefinite dysplasia/dysplasia subjects, and ORs were 3.65 (95% CI, 1.96-6.80) for anti-H. pylori, 2.43 (95% CI 1.34-4.39) for celecoxib, and 2.80 (95% CI, 1.52-5.15) for anti-H. pylori followed by celecoxib, respectively.	Celecoxib	240-249	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-90
27020655-5	2016	When stratified by baseline histology, the three active arms significantly decreased COX-2 methylation levels in indefinite dysplasia/dysplasia subjects, and ORs were 3.65 (95% CI, 1.96-6.80) for anti-H. pylori, 2.43 (95% CI 1.34-4.39) for celecoxib, and 2.80 (95% CI, 1.52-5.15) for anti-H. pylori followed by celecoxib, respectively.	Celecoxib	311-320	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-90
27020655-8	2016	These findings suggest that anti-H. pylori or celecoxib treatment alone could decrease COX-2 methylation levels in gastric mucosa.	Celecoxib	46-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-92
26155780-6	2016	RESULTS: PWE (25-200 mug/ml) dose dependently reduced COX-2-dependent PGE2 production in SK-N-SH cells stimulated with IL-1beta.	Dinoprostone	70-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-59
26538205-3	2016	METHODS: Fifty-seven healthy subjects were randomly assigned groups given the cyclooxygenase (COX) 2 inhibitor celecoxib (200 mg, twice daily) plus placebo for 2 weeks (COX-2 + placebo group, n = 30), or celecoxib plus the PPI rabeprazole (20 mg, once daily) for 2 weeks (COX-2 + PPI group, n = 27).	Celecoxib	111-120	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-100
27059979-0	2016	Interactions of 2-O-arachidonylglycerol ether and ibuprofen with the allosteric and catalytic subunits of human COX-2.	2-o-arachidonylglycerol ether	16-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-117
26944662-0	2016	Aqueous Co(II) adsorption using 8-hydroxyquinoline anchored gamma-Fe2O3@chitosan with Co(II) as imprinted ions.	Oxyquinoline	32-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	8-14
26944662-0	2016	Aqueous Co(II) adsorption using 8-hydroxyquinoline anchored gamma-Fe2O3@chitosan with Co(II) as imprinted ions.	Oxyquinoline	32-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-92
26944662-0	2016	Aqueous Co(II) adsorption using 8-hydroxyquinoline anchored gamma-Fe2O3@chitosan with Co(II) as imprinted ions.	gamma-fe2o3	60-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	8-14
26944662-0	2016	Aqueous Co(II) adsorption using 8-hydroxyquinoline anchored gamma-Fe2O3@chitosan with Co(II) as imprinted ions.	gamma-fe2o3	60-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-92
26944662-1	2016	A novel, bio-based 8-hydroxyquinoline (8-HQ) anchored magnetic chitosan using Co(II) as imprinted ions was prepared and applied for selective removal of Co(II) from aqueous solutions.	Oxyquinoline	19-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-84
26944662-1	2016	A novel, bio-based 8-hydroxyquinoline (8-HQ) anchored magnetic chitosan using Co(II) as imprinted ions was prepared and applied for selective removal of Co(II) from aqueous solutions.	Oxyquinoline	19-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	153-159
26944662-5	2016	The experimental results showed that equilibrium time was 10min moreover, the maximum adsorption capacity of Co(II) with non-imprinted and surface imprinted polymer at pH 8 were 66.6 and 100mgg(-1), respectively.	Polymers	157-164	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-115
26944662-6	2016	The selectivity coefficient of Co(II) ions relative to Cd(II), Ni(II) and Pb(II) were 11, 42 and 2, respectively.	cd(ii)	55-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-37
26944662-6	2016	The selectivity coefficient of Co(II) ions relative to Cd(II), Ni(II) and Pb(II) were 11, 42 and 2, respectively.	Nickel(2+)	63-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-37
26944662-6	2016	The selectivity coefficient of Co(II) ions relative to Cd(II), Ni(II) and Pb(II) were 11, 42 and 2, respectively.	pb(ii)	74-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-37
26836460-5	2016	GA inhibited UV-B-mediated activation of p38 and JNK MAP kinases, COX-2 expression and nuclear translocation of NF-kappaB.	Glycyrrhizic Acid	0-2	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-71
26808712-5	2016	In particular, functional and immunohistochemical experiments with selective COX inhibitors identified the isoform COX-2 as the main source of intravascular ROS generation in isolated small vessels from essential hypertensive patients.	Reactive Oxygen Species	157-160	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-120
27059979-0	2016	Interactions of 2-O-arachidonylglycerol ether and ibuprofen with the allosteric and catalytic subunits of human COX-2.	Ibuprofen	50-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-117
27059979-1	2016	Prostaglandin (PG) endoperoxide H synthase (PGHS)-2, also known as cyclooxygenase (COX)-2, can convert arachidonic acid (AA) to PGH2 in the committed step of PG synthesis.	Prostaglandins	0-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-89
27059979-1	2016	Prostaglandin (PG) endoperoxide H synthase (PGHS)-2, also known as cyclooxygenase (COX)-2, can convert arachidonic acid (AA) to PGH2 in the committed step of PG synthesis.	Arachidonic Acid	103-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-89
27059979-1	2016	Prostaglandin (PG) endoperoxide H synthase (PGHS)-2, also known as cyclooxygenase (COX)-2, can convert arachidonic acid (AA) to PGH2 in the committed step of PG synthesis.	Prostaglandin H2	128-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-89
27059979-1	2016	Prostaglandin (PG) endoperoxide H synthase (PGHS)-2, also known as cyclooxygenase (COX)-2, can convert arachidonic acid (AA) to PGH2 in the committed step of PG synthesis.	Prostaglandins	15-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-89
27014880-3	2016	In fact, diclofenac"s increased effect on spinal nociception and chronic neuro-inflammatory pain may be referred to: 1) its synergistic effects on peroxisome proliferator-activated receptor-gamma (PPAR- gamma) activation and prostaglandin synthesis inhibition (COX-2 inhibition); 2) its capacity of suppressing neuronal hyperexcitability through the blockage of neuronal K+ channels in a concentration-dependant manner; and 3) its facility to cross the blood-brain barrier.	Diclofenac	9-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	261-266
27054774-0	2016	3D chiral and 2D achiral cobalt(ii) compounds constructed from a 4-(benzimidazole-1-yl)benzoic ligand exhibiting field-induced single-ion-magnet-type slow magnetic relaxation.	(benzimidazole-1-yl	67-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-34
27108782-2	2016	We have previously reported the proliferation/anti-apoptosis/angiogenesis/migration effects of exogenous H2S on liver cancer and glioma via amplifying the activation of NF-kappaB and p38 MAPK/ERK1/2-COX-2 pathway.	Hydrogen Sulfide	105-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	199-204
27186601-0	2016	New Fe(iii) and Co(ii) salen complexes with pendant distamycins: selective targeting of cancer cells by DNA damage and mitochondrial pathways.	Distamycins	52-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-22
27186601-1	2016	Minor groove binding distamycin like moieties were conjugated with core salens and the corresponding Fe(iii) and Co(ii) complexes were synthesized.	stallimycin	21-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-119
27186601-1	2016	Minor groove binding distamycin like moieties were conjugated with core salens and the corresponding Fe(iii) and Co(ii) complexes were synthesized.	disalicylaldehyde ethylenediamine	72-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-119
27186601-4	2016	Interestingly, the Co(ii) complexes exhibited greater activity than the Fe(iii) complexes in accordance with the stronger affinity of the former in the biophysical studies.	ferric sulfate	72-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-25
27145282-1	2016	We reported previously that human fibroblasts release 5-methoxytryptophan (5-MTP) which inhibits cancer cell COX-2 overexpression and suppresses cancer cell migration and metastasis.	5-methoxytryptophan	54-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-114
27217781-8	2016	HER2-induced expression and promoter activity of COX-2 were also suppressed by U0126, suggesting that the MEK/ERK signaling pathway regulates COX-2 expression.	U 0126	79-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-54
27217781-8	2016	HER2-induced expression and promoter activity of COX-2 were also suppressed by U0126, suggesting that the MEK/ERK signaling pathway regulates COX-2 expression.	U 0126	79-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	142-147
27217781-10	2016	MTT and invasion assays revealed that HER2 induced cell proliferation and invasion that were reversed by pretreatment with U0126 and COX-2 siRNA.	monooxyethylene trimethylolpropane tristearate	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	133-138
27082443-1	2016	A series of hetero-bimetallic transition metal-substituted polyoxometalates (TMSPs) were synthesized based on the Co(II)-centered ligand [Co(II)W11O39](10-).	polyoxometalate I	59-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-120
27082443-1	2016	A series of hetero-bimetallic transition metal-substituted polyoxometalates (TMSPs) were synthesized based on the Co(II)-centered ligand [Co(II)W11O39](10-).	tmsps	77-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-120
27109804-0	2016	Meloxicam suppresses hepatocellular carcinoma cell proliferation and migration by targeting COX-2/PGE2-regulated activation of the beta-catenin signaling pathway.	Meloxicam	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-97
27109804-0	2016	Meloxicam suppresses hepatocellular carcinoma cell proliferation and migration by targeting COX-2/PGE2-regulated activation of the beta-catenin signaling pathway.	Dinoprostone	98-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-97
27109804-3	2016	Meloxicam is a selective COX-2 inhibitor that has been reported to exert an anti-proliferation and invasion/migration response in various tumors.	Meloxicam	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-30
27109804-6	2016	Furthermore, meloxicam suppressed the ability of HCC cells expressing higher levels of COX-2 and prostaglandin E2 (PGE2) to migration via potentiating expression of E-cadherin and alleviating expression of matrix metalloproteinase (MMP)-2 and -9.	Meloxicam	13-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-92
27109804-7	2016	COX-2/PGE2 has been considered to activate the beta-catenin signaling pathway which promotes cancer cell migration.	Dinoprostone	6-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
25429611-3	2016	The aim of the present study was to determine the effects of a cyclo-oxygenase (COX)-2 inhibitor (meloxicam) on gonadotropin-releasing hormone (GnRH) and LH secretion in anoestrous ewes during systemic inflammation induced by LPS.	Meloxicam	98-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-86
26656048-3	2016	SUMMARY OF BACKGROUND DATA: We previously reported that a selective COX-2 inhibitor enhanced, whereas PGE2 suppressed the induction of NGF by IL-1 in human IVD cells, and proposed that PGE2 can suppress NGF expression by a negative feedback mechanism.	Dinoprostone	185-189	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-73
27109712-0	2016	Probing bistability in Fe(II) and Co(II) complexes with an unsymmetrically substituted quinonoid ligand.	quinonoid	87-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-40
27109712-6	2016	Furthermore, we show here that the spin state of the Fe(II) complex can be influenced by temperature, pressure and light and the Co(II) complex displays redox-induced spin-state switching.	ammonium ferrous sulfate	53-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-135
26927686-0	2016	Indomethacin based new triazolothiadiazine derivatives: Synthesis, evaluation of their anticancer effects on T98 human glioma cell line related to COX-2 inhibition and docking studies.	Indomethacin	0-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-152
26927686-0	2016	Indomethacin based new triazolothiadiazine derivatives: Synthesis, evaluation of their anticancer effects on T98 human glioma cell line related to COX-2 inhibition and docking studies.	TRIAZOLOTHIADIAZINE	23-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-152
26927686-7	2016	The docking study suggested that the COX-2 inhibitory effects of compound 8 and indomethacin were similar in the catalytic active site of COX-2.	Indomethacin	80-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-42
26927686-7	2016	The docking study suggested that the COX-2 inhibitory effects of compound 8 and indomethacin were similar in the catalytic active site of COX-2.	Indomethacin	80-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	138-143
27142691-6	2016	Molecular analysis revealed that both glucocorticoids and pioglitazone enhanced glomerular synaptopodin and nephrin expression, and reduced COX-2 expression, after injury.	Pioglitazone	58-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-145
27064169-4	2016	Detailed mechanistic studies show that while the complexes retain the monodentate X ligand upon electrochemical reduction to Co(II) species in MeCN solution, in aqueous solution, upon reduction by ascorbate (photocatalytic conditions), [Co(II)(N4Py)(HA)](+) is formed in all cases and is the precursor to the Co(I) species which presumably reacts with a proton.	acetonitrile	143-147	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-131
27064169-4	2016	Detailed mechanistic studies show that while the complexes retain the monodentate X ligand upon electrochemical reduction to Co(II) species in MeCN solution, in aqueous solution, upon reduction by ascorbate (photocatalytic conditions), [Co(II)(N4Py)(HA)](+) is formed in all cases and is the precursor to the Co(I) species which presumably reacts with a proton.	Ascorbic Acid	197-206	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-131
27064169-4	2016	Detailed mechanistic studies show that while the complexes retain the monodentate X ligand upon electrochemical reduction to Co(II) species in MeCN solution, in aqueous solution, upon reduction by ascorbate (photocatalytic conditions), [Co(II)(N4Py)(HA)](+) is formed in all cases and is the precursor to the Co(I) species which presumably reacts with a proton.	Ascorbic Acid	197-206	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	237-243
27064169-4	2016	Detailed mechanistic studies show that while the complexes retain the monodentate X ligand upon electrochemical reduction to Co(II) species in MeCN solution, in aqueous solution, upon reduction by ascorbate (photocatalytic conditions), [Co(II)(N4Py)(HA)](+) is formed in all cases and is the precursor to the Co(I) species which presumably reacts with a proton.	histidinoalanine	250-253	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-131
27064169-4	2016	Detailed mechanistic studies show that while the complexes retain the monodentate X ligand upon electrochemical reduction to Co(II) species in MeCN solution, in aqueous solution, upon reduction by ascorbate (photocatalytic conditions), [Co(II)(N4Py)(HA)](+) is formed in all cases and is the precursor to the Co(I) species which presumably reacts with a proton.	histidinoalanine	250-253	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	237-243
27025376-7	2016	Combination treatment of cells with cetuximab and tectochrysin significantly reduced the expressions of p-EGFR and COX-2 in both cell lines.	tectochrysin	50-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-120
27054774-2	2016	Herein 3D chiral and 2D achiral cobalt(ii) coordination compounds based on single metal nodes with a 4-(benzimidazole-1-yl)benzoic acid (Hbmzbc) ligand, namely, [Co(bmzbc)2(1,2-etdio)]n () (1,2-etdio = 1,2-ethanediol) and [Co(bmzbc)2(Hbmzbc)]n (), have been synthesized and structurally characterized.	Metals	82-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-41
27054774-2	2016	Herein 3D chiral and 2D achiral cobalt(ii) coordination compounds based on single metal nodes with a 4-(benzimidazole-1-yl)benzoic acid (Hbmzbc) ligand, namely, [Co(bmzbc)2(1,2-etdio)]n () (1,2-etdio = 1,2-ethanediol) and [Co(bmzbc)2(Hbmzbc)]n (), have been synthesized and structurally characterized.	4-(benzimidazole-1-yl)benzoic acid	101-135	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-41
27054774-2	2016	Herein 3D chiral and 2D achiral cobalt(ii) coordination compounds based on single metal nodes with a 4-(benzimidazole-1-yl)benzoic acid (Hbmzbc) ligand, namely, [Co(bmzbc)2(1,2-etdio)]n () (1,2-etdio = 1,2-ethanediol) and [Co(bmzbc)2(Hbmzbc)]n (), have been synthesized and structurally characterized.	hbmzbc	137-143	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-41
27054774-2	2016	Herein 3D chiral and 2D achiral cobalt(ii) coordination compounds based on single metal nodes with a 4-(benzimidazole-1-yl)benzoic acid (Hbmzbc) ligand, namely, [Co(bmzbc)2(1,2-etdio)]n () (1,2-etdio = 1,2-ethanediol) and [Co(bmzbc)2(Hbmzbc)]n (), have been synthesized and structurally characterized.	co(bmzbc)2(1,2-etdio)]n	162-185	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-41
27054774-2	2016	Herein 3D chiral and 2D achiral cobalt(ii) coordination compounds based on single metal nodes with a 4-(benzimidazole-1-yl)benzoic acid (Hbmzbc) ligand, namely, [Co(bmzbc)2(1,2-etdio)]n () (1,2-etdio = 1,2-ethanediol) and [Co(bmzbc)2(Hbmzbc)]n (), have been synthesized and structurally characterized.	Ethylene Glycol	202-216	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-41
27054774-2	2016	Herein 3D chiral and 2D achiral cobalt(ii) coordination compounds based on single metal nodes with a 4-(benzimidazole-1-yl)benzoic acid (Hbmzbc) ligand, namely, [Co(bmzbc)2(1,2-etdio)]n () (1,2-etdio = 1,2-ethanediol) and [Co(bmzbc)2(Hbmzbc)]n (), have been synthesized and structurally characterized.	co(bmzbc)2(hbmzbc)	223-241	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-41
27025563-6	2016	Docking study of compounds 7a, 7e and 9 into the COX-2 binding site revealed a similar binding mode to SC-558, a selective COX-2 inhibitor.	SC 558	103-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-54
27025563-6	2016	Docking study of compounds 7a, 7e and 9 into the COX-2 binding site revealed a similar binding mode to SC-558, a selective COX-2 inhibitor.	SC 558	103-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-128
29997819-3	2016	Emphasis was given to the spectroscopic investigation of the coordination preferences and spin configurations among the different 3d6 CoIII, 3d7 CoII, and 3d8 CoI oxidation states of the metal, and to the catalytic proton reduction with an evaluation of the pathways for the generation of H2via CoIII-H- or CoII-H- intermediates by mono and bimetallic routes.	Metals	187-192	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-138
29997819-3	2016	Emphasis was given to the spectroscopic investigation of the coordination preferences and spin configurations among the different 3d6 CoIII, 3d7 CoII, and 3d8 CoI oxidation states of the metal, and to the catalytic proton reduction with an evaluation of the pathways for the generation of H2via CoIII-H- or CoII-H- intermediates by mono and bimetallic routes.	Metals	187-192	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-149
29997819-8	2016	The intermediacy of a trifluoroacetate-bound CoIII/CoII couple in the catalytic mechanism is proposed.	Trifluoroacetic Acid	22-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-49
27040110-4	2016	It was found that the crucial factor for the Co(II)-alpha benzoin oxime complex formation is the pH of the alkaline alcoholic medium.	alpha-Benzoin oxime	58-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-51
26922413-7	2016	Our study results suggest that genetic polymorphisms of COX2, EPHX1, CAT, and SOD2 modify the association of BPA with liver function.	bisphenol A	109-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-60
26984380-3	2016	HepG2 cells treated with CoCl2 was employed as a hypoxia cell model in vitro to study hypoxia-induced HIF-1alpha, COX-2 expression, and EMT alteration.	cobaltous chloride	25-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-119
26984380-7	2016	It was further verified that hypoxia enhanced protein expression of HIF-1alpha and COX-2 in HepG2 cells treated with CoCl2.	cobaltous chloride	117-122	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
26477987-4	2016	Pretreatment of cells with NS398, a COX-2 inhibitor, partially blunted this effect.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	27-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-41
26895560-8	2016	Downstream of PAR2, the cyclooxygenase (COX) inhibitor indomethacin, the COX2 inhibitor celecoxib or the thromboxane receptors blocker SQ29548 prevented the deleterious effects of sDPP4.	Celecoxib	88-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-77
26331692-1	2016	An exposure-response model was used to characterize the pharmacokinetic-pharmacodynamic relationship of GW406381, a COX-2 inhibitor, based on data from ex vivo prostaglandin E2 inhibition collected in a phase 1 study in healthy subjects.	GW406381X	104-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-121
26987083-0	2016	Hydrogen sulfide promotes cell proliferation of oral cancer through activation of the COX2/AKT/ERK1/2 axis.	Hydrogen Sulfide	0-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-90
26876621-9	2016	CONCLUSION: Our comprehensive analysis revealed that COX-2 inhibitors may be beneficial for suppressing aggrecan degradation and for reducing inflammatory pain by inhibiting PGE2 release, although they may have limited efficacy in suppressing collagen degradation and nerve growth.	Dinoprostone	174-178	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-58
25787879-5	2016	DGC treatment attenuated TPA-induced activator protein-1 (AP-1) and nuclear factor-kappaB (NF-kappaB) transcriptional activation, two major regulators of TPA-induced cell transformation, and COX-2 expression.	Tetradecanoylphorbol Acetate	25-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	191-196
27079258-7	2016	In addition, CuNP induced the expression of COX-2 and the production of PGE2 through arginase activation.	cunp	13-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-49
26987083-5	2016	Our results showed that hydrogen sulfide promoted oral cancer cell proliferation through activation of the COX2, AKT and ERK1/2 pathways in a dose-dependent manner.	Hydrogen Sulfide	24-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-111
26987083-7	2016	Meanwhile, blockade of COX2 by niflumic acid downregulated NaHS-induced p-ERK and p-AKT expression.	Niflumic Acid	31-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-27
26987083-7	2016	Meanwhile, blockade of COX2 by niflumic acid downregulated NaHS-induced p-ERK and p-AKT expression.	sodium bisulfide	59-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-27
26987083-10	2016	Our data revealed, for the first time, that hydrogen sulfide promotes oral cancer cell proliferation through activation of the COX2/AKT/ERK1/2 axis, suggesting new potential targets to eliminate the effect of hydrogen sulfide on the development of oral cancer.	Hydrogen Sulfide	44-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	127-131
26987083-10	2016	Our data revealed, for the first time, that hydrogen sulfide promotes oral cancer cell proliferation through activation of the COX2/AKT/ERK1/2 axis, suggesting new potential targets to eliminate the effect of hydrogen sulfide on the development of oral cancer.	Hydrogen Sulfide	209-225	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	127-131
27086487-14	2016	CONCLUSION: Our results suggested that COX-2 and HB-EGF are important in development of HNSCC cisplatin resistance.	Cisplatin	94-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-44
27086487-0	2016	Up-regulation of HB-EGF by the COX-2/PGE2 signaling associates with the cisplatin resistance and tumor recurrence of advanced HNSCC.	Cisplatin	72-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-36
27086487-4	2016	Both HB-EGF and COX-2 have been reported to increase cisplatin-resistance.	Cisplatin	53-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-21
27086487-5	2016	Here, we have focused on the regulation of HB-EGF/COX-2 and their roles in cisplatin resistance.	Cisplatin	75-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-55
27086487-9	2016	RESULTS: Patients of advanced HNSCC patients with increased HB-EGF and COX-2 expression have higher tumor recurrent rates that was related to cisplatin resistance.	Cisplatin	142-151	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-76
27086487-11	2016	The activation of Akt by either EGF or areca nut extract were able to upregulate COX-2, which would increase the expression of HB-EGF in a PGE2 dependent manner.	Dinoprostone	139-143	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-86
26801201-1	2016	COX-2 and its product PGE2 enhance carcinogenesis and tumor progression, which has been previously reported in melanoma.	Dinoprostone	22-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
26900671-4	2016	While the gas adsorption experiments reveal that Cu(II) and Co(II) exchanged samples exhibit comparable CO2 adsorption capability to the pristine Zn(II) -based MOF under the same conditions, catalytic investigations for the cycloaddition reaction of CO2 with epoxides into related carbonates demonstrate that Zn(II) -based MOF affords the highest catalytic activity as compared with Cu(II) and Co(II) exchanged ones.	cu(ii)	49-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	394-400
26900671-4	2016	While the gas adsorption experiments reveal that Cu(II) and Co(II) exchanged samples exhibit comparable CO2 adsorption capability to the pristine Zn(II) -based MOF under the same conditions, catalytic investigations for the cycloaddition reaction of CO2 with epoxides into related carbonates demonstrate that Zn(II) -based MOF affords the highest catalytic activity as compared with Cu(II) and Co(II) exchanged ones.	N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)-4-((4-fluorobenzyl)oxy)pyridine-2,6-dicarboxamide	104-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-66
26900671-4	2016	While the gas adsorption experiments reveal that Cu(II) and Co(II) exchanged samples exhibit comparable CO2 adsorption capability to the pristine Zn(II) -based MOF under the same conditions, catalytic investigations for the cycloaddition reaction of CO2 with epoxides into related carbonates demonstrate that Zn(II) -based MOF affords the highest catalytic activity as compared with Cu(II) and Co(II) exchanged ones.	Zinc	146-152	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-66
26900671-4	2016	While the gas adsorption experiments reveal that Cu(II) and Co(II) exchanged samples exhibit comparable CO2 adsorption capability to the pristine Zn(II) -based MOF under the same conditions, catalytic investigations for the cycloaddition reaction of CO2 with epoxides into related carbonates demonstrate that Zn(II) -based MOF affords the highest catalytic activity as compared with Cu(II) and Co(II) exchanged ones.	N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)-4-((4-fluorobenzyl)oxy)pyridine-2,6-dicarboxamide	250-253	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-66
26900671-4	2016	While the gas adsorption experiments reveal that Cu(II) and Co(II) exchanged samples exhibit comparable CO2 adsorption capability to the pristine Zn(II) -based MOF under the same conditions, catalytic investigations for the cycloaddition reaction of CO2 with epoxides into related carbonates demonstrate that Zn(II) -based MOF affords the highest catalytic activity as compared with Cu(II) and Co(II) exchanged ones.	Epoxy Compounds	259-267	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-66
26900671-4	2016	While the gas adsorption experiments reveal that Cu(II) and Co(II) exchanged samples exhibit comparable CO2 adsorption capability to the pristine Zn(II) -based MOF under the same conditions, catalytic investigations for the cycloaddition reaction of CO2 with epoxides into related carbonates demonstrate that Zn(II) -based MOF affords the highest catalytic activity as compared with Cu(II) and Co(II) exchanged ones.	Carbonates	281-291	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-66
26900671-4	2016	While the gas adsorption experiments reveal that Cu(II) and Co(II) exchanged samples exhibit comparable CO2 adsorption capability to the pristine Zn(II) -based MOF under the same conditions, catalytic investigations for the cycloaddition reaction of CO2 with epoxides into related carbonates demonstrate that Zn(II) -based MOF affords the highest catalytic activity as compared with Cu(II) and Co(II) exchanged ones.	Zinc	309-315	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-66
26900671-4	2016	While the gas adsorption experiments reveal that Cu(II) and Co(II) exchanged samples exhibit comparable CO2 adsorption capability to the pristine Zn(II) -based MOF under the same conditions, catalytic investigations for the cycloaddition reaction of CO2 with epoxides into related carbonates demonstrate that Zn(II) -based MOF affords the highest catalytic activity as compared with Cu(II) and Co(II) exchanged ones.	cu(ii)	383-389	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-66
26631035-7	2016	Celecoxib showed anti-cancer effects in both COX-2 dependent and independent pathways and used to act as a radiosensitizing enhancer.	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-50
26940876-5	2016	Concomitant up-regulation of several cell signaling molecules after DETA-NO preconditioning was observed by Western blotting, including elevated phosphorylation of NRF2, NFkappaB, STAT3, ERK, and AKT, as well as increased protein expression of HO-1 and COX2.	DEET	68-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	253-257
27019020-2	2016	A novel coordination environment for Co(II) is observed including a weak but significant Fe-Co interaction, which was characterized using X-ray crystallography, Mossbauer spectroscopy, and VT-magnetometry.	Iron	89-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-43
27022765-0	2016	Two Isostructural Coordination Polymers Showing Diverse Magnetic Behaviors: Weak Coupling (Ni(II)) and an Ordered Array of Single-Chain Magnets (Co(II)).	Polymers	31-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-151
27143925-7	2016	Then, treatment of Tca-8113 cells with carvacrol resulted in downregulation of Bcl-2, Cox2, and upregulation of Bax.	Trichloroacetic Acid	19-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-90
27143925-7	2016	Then, treatment of Tca-8113 cells with carvacrol resulted in downregulation of Bcl-2, Cox2, and upregulation of Bax.	carvacrol	39-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-90
27010501-0	2016	Evaluation of the anti-inflammatory action of curcumin analog (DM1): Effect on iNOS and COX-2 gene expression and autophagy pathways.	Curcumin	46-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-93
27014926-8	2016	A 2.6 A resolution X-ray crystal structure of a complex between oxalate and the Co(II)-substituted DeltaE162 OxDC variant, in which Glu(162) has been deleted from the active site loop, reveals the likely mode by which the substrate coordinates the catalytically active Mn ion prior to C-C bond cleavage.	Oxalates	64-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-85
27014926-8	2016	A 2.6 A resolution X-ray crystal structure of a complex between oxalate and the Co(II)-substituted DeltaE162 OxDC variant, in which Glu(162) has been deleted from the active site loop, reveals the likely mode by which the substrate coordinates the catalytically active Mn ion prior to C-C bond cleavage.	Glutamic Acid	132-135	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-85
27014926-8	2016	A 2.6 A resolution X-ray crystal structure of a complex between oxalate and the Co(II)-substituted DeltaE162 OxDC variant, in which Glu(162) has been deleted from the active site loop, reveals the likely mode by which the substrate coordinates the catalytically active Mn ion prior to C-C bond cleavage.	Carbon	112-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-85
26915975-0	2016	In vitro antiproliferative activity of 2,3-dihydroxy-9,10-anthraquinone induced apoptosis against COLO320 cells through cytochrome c release caspase mediated pathway with PI3K/AKT and COX-2 inhibition.	2,3-dihydroxy-9,10-anthraquinone	39-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	184-189
27146576-4	2016	In the crystal structure, each Co(II) cation is surrounded by three N atoms of a PTP ligand and three O atoms, two from a bidentate and one from a symmetry-related monodentate 4,4"-oxydibenzoate (ODA(2-)) ligand, completing a distorted octahedral coordination geometry.	4,4"-oxydibenzoate	176-194	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-37
27146576-4	2016	In the crystal structure, each Co(II) cation is surrounded by three N atoms of a PTP ligand and three O atoms, two from a bidentate and one from a symmetry-related monodentate 4,4"-oxydibenzoate (ODA(2-)) ligand, completing a distorted octahedral coordination geometry.	di-(4-aminophenyl)ether	196-199	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-37
26900671-2	2016	Subsequently, single-crystal-to-single-crystal metal cation exchange using the constructed MOF is investigated, and the results show that Cu(II) and Co(II) ions can selectively be introduced into the MOF without compromising the crystallinity of the pristine framework.	Metals	47-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	149-155
27124181-6	2016	Targeted LC-MS/MS lipidomic analysis identified increased PGE2 levels in obese fat in the context of a remarkable COX-2 induction and in the absence of changes in the expression of terminal prostaglandin E synthases (i.e. mPGES-1, mPGES-2 and cPGES).	Dinoprostone	58-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-119
26997130-3	2016	In contrast, the Co(II) centres in the unreduced analogue [(HAN){Co(N"")2 }3 ] are weakly coupled (J -4.4 cm(-1) ).	co(n"")2 }3	65-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-23
26956368-0	2016	Charge transfer complexes of fullerenes containing C60 - and C70 - radical anions with paramagnetic Co(II)(dppe)2Cl+ cations (dppe: 1,2-bis(diphenylphosphino)ethane).	Fullerenes	29-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-105
26956368-0	2016	Charge transfer complexes of fullerenes containing C60 - and C70 - radical anions with paramagnetic Co(II)(dppe)2Cl+ cations (dppe: 1,2-bis(diphenylphosphino)ethane).	dppe	107-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-105
26956368-0	2016	Charge transfer complexes of fullerenes containing C60 - and C70 - radical anions with paramagnetic Co(II)(dppe)2Cl+ cations (dppe: 1,2-bis(diphenylphosphino)ethane).	bis(diphenylphosphine)ethane	132-164	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-105
26956368-1	2016	The reduction of Co(II)(dppe)Cl2 with sodium fluorenone ketyl produces a red solution containing the Co(I) species.	sodium fluorenone ketyl	38-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22
26956368-9	2016	These signals originate from the exchange interaction between the paramagnetic Co(II)(dppe)2Cl(+) cations and the fullerene (-) radical anions.	Fullerenes	114-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-84
26826540-7	2016	Prophylactic administration of meloxicam, a preferential inhibitor of COX-2 activity, prevented both central inflammation and deficits in affective-like behaviors.	Meloxicam	31-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-75
26983759-0	2016	Syntheses and magnetic properties of a pyrimidyl-substituted nitronyl nitroxide radical and its cobalt(ii) complexes.	pyrimidyl-substituted nitronyl nitroxide radical	39-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-105
26983759-1	2016	A new bis-bidentate nitronyl nitroxide radical with a pyrimidyl substituent group and two Co(ii) complexes of this ligand were synthesized and characterized.	bis-bidentate nitronyl nitroxide radical	6-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-96
27045367-5	2016	Furthermore, naringenin downregulated KO2-induced mRNA expression of gp91phox, cyclooxygenase (COX)-2, and preproendothelin-1.	naringenin	13-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-101
27045367-5	2016	Furthermore, naringenin downregulated KO2-induced mRNA expression of gp91phox, cyclooxygenase (COX)-2, and preproendothelin-1.	ko2	38-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-101
26974224-5	2016	Best-fit analysis of chiT versus T showed that the anisotropic contribution (arising from a large zero-field splitting in Co(II) ions) dominates (weak-exchange limit) in the Co(II)2Eu(III)2 complex (D = 20.5 cm(-1), J = -0.4 cm(-1), gCo = 2.22).	Cobalt(2+)	174-180	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-128
26931344-8	2016	CONCLUSIONS: Celecoxib, both in vitro and in vivo, induced apoptosis of colorectal cancer cells but increased the VEGF levels at the same time in a COX-2-independent manner, namely by activating ER stress.	Celecoxib	13-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	148-153
26944612-4	2016	Molecular docking interactions of dimethylamino curcuminoids derivatives against cyclooxygenase enzymes (COX-1 and COX-2) were studied.	dimethylamino curcuminoids	34-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-120
26931344-1	2016	PURPOSE: In our previous study, we found that celecoxib, a kind of COX-2 inhibitor, led to cell apoptosis while up-regulating the expression of vascular endothelial growth factor (VEGF) in colorectal cancer HCT116 cells (COX-2 deficient), and endoplasmic reticulum (ER) stress was involved in the mechanism.	Celecoxib	46-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-72
26931344-1	2016	PURPOSE: In our previous study, we found that celecoxib, a kind of COX-2 inhibitor, led to cell apoptosis while up-regulating the expression of vascular endothelial growth factor (VEGF) in colorectal cancer HCT116 cells (COX-2 deficient), and endoplasmic reticulum (ER) stress was involved in the mechanism.	Celecoxib	46-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	221-226
26802265-3	2016	It was found that DDT was efficiently degraded in the PMS/Co(II) solutions within several hours, and the degradation efficiency of DDT was dependent on the concentrations of PMS and Co(II), and the optimum molar ratio of PMS and Co(II) was 50:1.	DDT	18-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-64
26802265-3	2016	It was found that DDT was efficiently degraded in the PMS/Co(II) solutions within several hours, and the degradation efficiency of DDT was dependent on the concentrations of PMS and Co(II), and the optimum molar ratio of PMS and Co(II) was 50:1.	DDT	18-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	182-188
26802265-3	2016	It was found that DDT was efficiently degraded in the PMS/Co(II) solutions within several hours, and the degradation efficiency of DDT was dependent on the concentrations of PMS and Co(II), and the optimum molar ratio of PMS and Co(II) was 50:1.	DDT	18-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	182-188
26802265-3	2016	It was found that DDT was efficiently degraded in the PMS/Co(II) solutions within several hours, and the degradation efficiency of DDT was dependent on the concentrations of PMS and Co(II), and the optimum molar ratio of PMS and Co(II) was 50:1.	peroxymonosulfate	54-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-64
26802265-3	2016	It was found that DDT was efficiently degraded in the PMS/Co(II) solutions within several hours, and the degradation efficiency of DDT was dependent on the concentrations of PMS and Co(II), and the optimum molar ratio of PMS and Co(II) was 50:1.	peroxymonosulfate	54-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	182-188
26802265-3	2016	It was found that DDT was efficiently degraded in the PMS/Co(II) solutions within several hours, and the degradation efficiency of DDT was dependent on the concentrations of PMS and Co(II), and the optimum molar ratio of PMS and Co(II) was 50:1.	peroxymonosulfate	54-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	182-188
26802265-3	2016	It was found that DDT was efficiently degraded in the PMS/Co(II) solutions within several hours, and the degradation efficiency of DDT was dependent on the concentrations of PMS and Co(II), and the optimum molar ratio of PMS and Co(II) was 50:1.	DDT	131-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-64
26802265-3	2016	It was found that DDT was efficiently degraded in the PMS/Co(II) solutions within several hours, and the degradation efficiency of DDT was dependent on the concentrations of PMS and Co(II), and the optimum molar ratio of PMS and Co(II) was 50:1.	DDT	131-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	182-188
26802265-3	2016	It was found that DDT was efficiently degraded in the PMS/Co(II) solutions within several hours, and the degradation efficiency of DDT was dependent on the concentrations of PMS and Co(II), and the optimum molar ratio of PMS and Co(II) was 50:1.	DDT	131-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	182-188
26802265-3	2016	It was found that DDT was efficiently degraded in the PMS/Co(II) solutions within several hours, and the degradation efficiency of DDT was dependent on the concentrations of PMS and Co(II), and the optimum molar ratio of PMS and Co(II) was 50:1.	peroxymonosulfate	174-177	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-64
26802265-3	2016	It was found that DDT was efficiently degraded in the PMS/Co(II) solutions within several hours, and the degradation efficiency of DDT was dependent on the concentrations of PMS and Co(II), and the optimum molar ratio of PMS and Co(II) was 50:1.	peroxymonosulfate	174-177	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-64
26280673-4	2016	Treatment of human immortalized HaCaT keratinocytes with calcitriol (3-100 nM, 2-24 h) increased PGE2 production due to increased mRNA and protein expression of COX-2, but not to increase of COX-1 or release of arachidonic acid.	Calcitriol	57-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	161-166
26280673-5	2016	The effect of calcitriol on COX-2 mRNA was observed also in primary human keratinocytes.	Calcitriol	14-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
26280673-8	2016	Treatment with a COX-2 inhibitor partially prevented the attenuation of the keratinocyte inflammatory response by calcitriol.	Calcitriol	114-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22
26280673-9	2016	We conclude that upregulation of COX-2 expression with the consequent increase in PGE2 synthesis may be one of the mechanisms explaining the Janus face of calcitriol as both a promoter and attenuator of cutaneous inflammation.	Dinoprostone	82-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-38
26280673-9	2016	We conclude that upregulation of COX-2 expression with the consequent increase in PGE2 synthesis may be one of the mechanisms explaining the Janus face of calcitriol as both a promoter and attenuator of cutaneous inflammation.	Calcitriol	155-165	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-38
26916231-0	2016	Synthesis of 2-(methylsulfonyl)-5-(4-(methylsulfonyl) phenyl)-4-phenyl-1H-[5-(14)C]imidazole, a selective COX-2 inhibitor, via asymmetrical benzoins.	2-(methylsulfonyl)-5-(4-(methylsulfonyl)phenyl)-4-phenyl-1H-imidazole	13-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-111
26916231-0	2016	Synthesis of 2-(methylsulfonyl)-5-(4-(methylsulfonyl) phenyl)-4-phenyl-1H-[5-(14)C]imidazole, a selective COX-2 inhibitor, via asymmetrical benzoins.	Benzoin	140-148	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-111
26869668-8	2016	Lastly, DCF-AG was screened for pharmacologic activity against COX-1 and COX-2 and was found to have IC50 values of 0.620 +- 0.105 and 2.91 +- 0.36 muM, respectively, which represents a novel finding.	dcf-ag	8-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-78
26838881-2	2016	Etoricoxib (COX-2 inhibitor), a highly hydrophobic drug was chosen as a model drug for the study.	Etoricoxib	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-17
26656634-5	2016	Quercetin-loaded NPs can significantly block UVB irradiation induced COX-2 up-expression and NF-kB activation in Hacat cell line.	Quercetin	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-74
26431978-5	2016	Consistently, recent evidence has confirmed that CFTR plays a major role in the osteoprotegerin (OPG) and COX-2 metabolite prostaglandin E2 (PGE2) production, two key regulators in the bone formation and regeneration.	Dinoprostone	123-139	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-111
26431978-5	2016	Consistently, recent evidence has confirmed that CFTR plays a major role in the osteoprotegerin (OPG) and COX-2 metabolite prostaglandin E2 (PGE2) production, two key regulators in the bone formation and regeneration.	Dinoprostone	141-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-111
27241143-8	2016	The caspase-3 activities were significantly increased in T24 cells in the osthole group compared with control group, while the expression of angiogenesis related-protein COX-2, VEGF, and NF-kappaB in T24 cells were decreased.	osthol	74-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	170-175
27375886-2	2016	In the chain complex that extends along the c axis, the Co(II) atom is six-coordinated, the O-donor atoms of the chelating acac ligands occupying the equatorial positions and the bridging DABCO ligands being in trans-axial positions.	triethylenediamine	188-193	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-62
27375886-4	2016	The metal-metal distance is very close to that in a related compound exhibiting weak anti-ferromagnetic exchange between the Co(II) ions, and the title compound can thus be useful for obtaining more information about the contribution of different bridges to the magnetic coupling between paramagnetic ions.	Metals	4-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-131
27375886-4	2016	The metal-metal distance is very close to that in a related compound exhibiting weak anti-ferromagnetic exchange between the Co(II) ions, and the title compound can thus be useful for obtaining more information about the contribution of different bridges to the magnetic coupling between paramagnetic ions.	Metals	10-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-131
26998549-0	2016	Unusual Recognition and Separation of Hydrated Metal Sulfates [M2(mu-SO4)2(H2O)n, M = Zn(II), Cd(II), Co(II), Mn(II)] by a Ditopic Receptor.	(mu-so4)2	65-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-108
26998549-7	2016	Sulfate salts of Cd(II)/Co(II) also exhibit binding constants in the order of ~1 x 10(6) as in the case of ZnSO4.	Sulfates	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-30
26998549-7	2016	Sulfate salts of Cd(II)/Co(II) also exhibit binding constants in the order of ~1 x 10(6) as in the case of ZnSO4.	cd(ii)	17-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-30
26998549-7	2016	Sulfate salts of Cd(II)/Co(II) also exhibit binding constants in the order of ~1 x 10(6) as in the case of ZnSO4.	Zinc Sulfate	107-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-30
30090276-0	2016	Multiscale study of mononuclear CoII SMMs based on curcuminoid ligands.	curcuminoid	51-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-36
30090276-1	2016	This work introduces a novel family of CoII species having a curcuminoid (CCMoid) ligand, 9Accm, attached, namely [Co(9Accm)2(py)2] (1) and [Co(9Accm)2(2,2"-bpy)] (2), achieved in high yields by the use of a microwave reactor, and exhibiting two different arrangements for the 9Accm ligands, described as "cis"(2) and "trans"(1).	curcuminoid	61-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-43
30090276-1	2016	This work introduces a novel family of CoII species having a curcuminoid (CCMoid) ligand, 9Accm, attached, namely [Co(9Accm)2(py)2] (1) and [Co(9Accm)2(2,2"-bpy)] (2), achieved in high yields by the use of a microwave reactor, and exhibiting two different arrangements for the 9Accm ligands, described as "cis"(2) and "trans"(1).	ccmoid	74-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-43
26844393-1	2016	A novel adsorbent, poly(itaconic acid/methacrylic acid)-grafted-nanocellulose/nanobentonite composite [P(IA/MAA)-g-NC/NB] with multi carboxyl functional groups for the effective removal of Cobalt(II) [Co(II)] from aqueous solutions.	poly(itaconic acid	19-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	189-199
26844393-1	2016	A novel adsorbent, poly(itaconic acid/methacrylic acid)-grafted-nanocellulose/nanobentonite composite [P(IA/MAA)-g-NC/NB] with multi carboxyl functional groups for the effective removal of Cobalt(II) [Co(II)] from aqueous solutions.	poly(itaconic acid	19-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	201-207
26844393-3	2016	FTIR spectra revealed that Co(II) adsorption on to the polymer may be due to the involvement of COOH groups.	Polymers	55-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-33
26844393-3	2016	FTIR spectra revealed that Co(II) adsorption on to the polymer may be due to the involvement of COOH groups.	Carbonic Acid	96-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-33
26936488-11	2016	Both Zn(II)-CP-1(CAHH) and Co(II)-CP-1(CAHH) show good hydrolytic activity toward the test substrate 4-nitrophenyl acetate, exhibiting faster rates than most active synthetic Zn(II) complexes.	4-nitrophenyl acetate	101-122	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-33
26936488-11	2016	Both Zn(II)-CP-1(CAHH) and Co(II)-CP-1(CAHH) show good hydrolytic activity toward the test substrate 4-nitrophenyl acetate, exhibiting faster rates than most active synthetic Zn(II) complexes.	Zinc	5-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-33
26687822-10	2016	Blocking of ERK, SAPK/JNK, and p38 MAPK inhibited the CTS-induced stimulation of COX-2 and IL-8, while IL-6 expression was mediated only by SAPK/JNK and p38 MAPK.	castanospermine	54-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-86
26922534-6	2016	COX-2 expression was decreased while PPARdelta expression and cPLA2 activity was increased after fatty acid supplementation and PAHs treatment.	Fatty Acids	97-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
26922534-6	2016	COX-2 expression was decreased while PPARdelta expression and cPLA2 activity was increased after fatty acid supplementation and PAHs treatment.	Polycyclic Aromatic Hydrocarbons	128-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
26922534-9	2016	The altered profile of lipid mediators from n-3 FA as well as repression of the COX-2 protein by n-3 PUFAs in A549 cells incubated with PAHs suggests anti-inflammatory and pro-resolving properties of DHA and EPA.	Polycyclic Aromatic Hydrocarbons	136-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-85
26922534-9	2016	The altered profile of lipid mediators from n-3 FA as well as repression of the COX-2 protein by n-3 PUFAs in A549 cells incubated with PAHs suggests anti-inflammatory and pro-resolving properties of DHA and EPA.	Dihydroalprenolol	200-203	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-85
26922534-9	2016	The altered profile of lipid mediators from n-3 FA as well as repression of the COX-2 protein by n-3 PUFAs in A549 cells incubated with PAHs suggests anti-inflammatory and pro-resolving properties of DHA and EPA.	Eicosapentaenoic Acid	208-211	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-85
27023525-18	2016	CORM-2 decreased NO and increased HO-1 expression and CO and COHb content, downregulated HIF-1alpha, as well as WRS-elevated COX-2 and iNOS mRNAs.	Carbon Monoxide	0-2	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-130
27042204-1	2016	BACKGROUND: Heteroligand Co(II) complexes involving imidazole and selected bio-relevant L-alpha-amino acids of four different groups (aspartic acid, lysine, histidine and asparagine) were formed by using a polymeric, pseudo-tetrahedral, semi-conductive Co(II) complex with imidazole-[Co(imid)2]n as starting material.	imidazole	52-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-31
27042204-1	2016	BACKGROUND: Heteroligand Co(II) complexes involving imidazole and selected bio-relevant L-alpha-amino acids of four different groups (aspartic acid, lysine, histidine and asparagine) were formed by using a polymeric, pseudo-tetrahedral, semi-conductive Co(II) complex with imidazole-[Co(imid)2]n as starting material.	imidazole	52-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	253-259
27042204-1	2016	BACKGROUND: Heteroligand Co(II) complexes involving imidazole and selected bio-relevant L-alpha-amino acids of four different groups (aspartic acid, lysine, histidine and asparagine) were formed by using a polymeric, pseudo-tetrahedral, semi-conductive Co(II) complex with imidazole-[Co(imid)2]n as starting material.	l-alpha-amino acids	88-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-31
27042204-1	2016	BACKGROUND: Heteroligand Co(II) complexes involving imidazole and selected bio-relevant L-alpha-amino acids of four different groups (aspartic acid, lysine, histidine and asparagine) were formed by using a polymeric, pseudo-tetrahedral, semi-conductive Co(II) complex with imidazole-[Co(imid)2]n as starting material.	l-alpha-amino acids	88-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	253-259
27042204-1	2016	BACKGROUND: Heteroligand Co(II) complexes involving imidazole and selected bio-relevant L-alpha-amino acids of four different groups (aspartic acid, lysine, histidine and asparagine) were formed by using a polymeric, pseudo-tetrahedral, semi-conductive Co(II) complex with imidazole-[Co(imid)2]n as starting material.	Aspartic Acid	134-147	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-31
27042204-1	2016	BACKGROUND: Heteroligand Co(II) complexes involving imidazole and selected bio-relevant L-alpha-amino acids of four different groups (aspartic acid, lysine, histidine and asparagine) were formed by using a polymeric, pseudo-tetrahedral, semi-conductive Co(II) complex with imidazole-[Co(imid)2]n as starting material.	Aspartic Acid	134-147	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	253-259
27042204-1	2016	BACKGROUND: Heteroligand Co(II) complexes involving imidazole and selected bio-relevant L-alpha-amino acids of four different groups (aspartic acid, lysine, histidine and asparagine) were formed by using a polymeric, pseudo-tetrahedral, semi-conductive Co(II) complex with imidazole-[Co(imid)2]n as starting material.	Lysine	149-155	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-31
27042204-1	2016	BACKGROUND: Heteroligand Co(II) complexes involving imidazole and selected bio-relevant L-alpha-amino acids of four different groups (aspartic acid, lysine, histidine and asparagine) were formed by using a polymeric, pseudo-tetrahedral, semi-conductive Co(II) complex with imidazole-[Co(imid)2]n as starting material.	Lysine	149-155	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	253-259
27042204-1	2016	BACKGROUND: Heteroligand Co(II) complexes involving imidazole and selected bio-relevant L-alpha-amino acids of four different groups (aspartic acid, lysine, histidine and asparagine) were formed by using a polymeric, pseudo-tetrahedral, semi-conductive Co(II) complex with imidazole-[Co(imid)2]n as starting material.	Histidine	157-166	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-31
27042204-1	2016	BACKGROUND: Heteroligand Co(II) complexes involving imidazole and selected bio-relevant L-alpha-amino acids of four different groups (aspartic acid, lysine, histidine and asparagine) were formed by using a polymeric, pseudo-tetrahedral, semi-conductive Co(II) complex with imidazole-[Co(imid)2]n as starting material.	Histidine	157-166	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	253-259
27042204-1	2016	BACKGROUND: Heteroligand Co(II) complexes involving imidazole and selected bio-relevant L-alpha-amino acids of four different groups (aspartic acid, lysine, histidine and asparagine) were formed by using a polymeric, pseudo-tetrahedral, semi-conductive Co(II) complex with imidazole-[Co(imid)2]n as starting material.	Asparagine	171-181	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-31
27042204-1	2016	BACKGROUND: Heteroligand Co(II) complexes involving imidazole and selected bio-relevant L-alpha-amino acids of four different groups (aspartic acid, lysine, histidine and asparagine) were formed by using a polymeric, pseudo-tetrahedral, semi-conductive Co(II) complex with imidazole-[Co(imid)2]n as starting material.	Asparagine	171-181	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	253-259
27042204-1	2016	BACKGROUND: Heteroligand Co(II) complexes involving imidazole and selected bio-relevant L-alpha-amino acids of four different groups (aspartic acid, lysine, histidine and asparagine) were formed by using a polymeric, pseudo-tetrahedral, semi-conductive Co(II) complex with imidazole-[Co(imid)2]n as starting material.	imidazole-[co(imid)2]n	273-295	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-31
27042204-4	2016	Precise knowledge of equilibria under oxygen-free conditions would enable evaluation of the reversible oxygen uptake in the same Co(II)-amino acid-imidazole systems, which are known models of artificial blood-substituting agents.	imidazole	147-156	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-135
27042204-11	2016	The parameter Deltalog10 K, which describes the influence of the bonded primary ligand in the binary complex Co(II)(Himid) towards an incoming secondary ligand (L) forming a heteroligand complex, was negative for all the Amac ligands (except for histidine, which shows stacking interactions).	himid	116-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-115
26859480-6	2016	Thione and selone coordination to Fe(ii) lowers the Fe(ii/iii) reduction potential, with a greater decrease for Fe(ii)-bound dmise than Fe(ii)-bound dmit.	Thiones	0-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-57
27231478-6	2016	The X-ray crystal structure of COX2 / 5-LOX enzymes and alpha-amyrins was retrieved and energetically minimized respectively.	beta-amyrin	56-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-35
26859480-0	2016	Synthesis, characterization, DFT calculations, and electrochemical comparison of novel iron(ii) complexes with thione and selone ligands.	Thiones	111-117	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-94
26859480-0	2016	Synthesis, characterization, DFT calculations, and electrochemical comparison of novel iron(ii) complexes with thione and selone ligands.	selone	122-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-94
26859480-2	2016	Although Cu(i/ii), Co(ii), Ag(i), and Zn(ii) coordination to thione and selone ligands has been broadly studied and Fe(ii) plays an important role in oxidative damage, very few iron-thione complexes and no iron-selone complexes are reported.	Copper	9-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-16
26859480-2	2016	Although Cu(i/ii), Co(ii), Ag(i), and Zn(ii) coordination to thione and selone ligands has been broadly studied and Fe(ii) plays an important role in oxidative damage, very few iron-thione complexes and no iron-selone complexes are reported.	Thiones	61-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-16
26859480-2	2016	Although Cu(i/ii), Co(ii), Ag(i), and Zn(ii) coordination to thione and selone ligands has been broadly studied and Fe(ii) plays an important role in oxidative damage, very few iron-thione complexes and no iron-selone complexes are reported.	Thiones	61-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-25
26859480-2	2016	Although Cu(i/ii), Co(ii), Ag(i), and Zn(ii) coordination to thione and selone ligands has been broadly studied and Fe(ii) plays an important role in oxidative damage, very few iron-thione complexes and no iron-selone complexes are reported.	Thiones	61-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-24
26859480-2	2016	Although Cu(i/ii), Co(ii), Ag(i), and Zn(ii) coordination to thione and selone ligands has been broadly studied and Fe(ii) plays an important role in oxidative damage, very few iron-thione complexes and no iron-selone complexes are reported.	Thiones	61-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-24
26859480-2	2016	Although Cu(i/ii), Co(ii), Ag(i), and Zn(ii) coordination to thione and selone ligands has been broadly studied and Fe(ii) plays an important role in oxidative damage, very few iron-thione complexes and no iron-selone complexes are reported.	selone	72-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-16
26859480-2	2016	Although Cu(i/ii), Co(ii), Ag(i), and Zn(ii) coordination to thione and selone ligands has been broadly studied and Fe(ii) plays an important role in oxidative damage, very few iron-thione complexes and no iron-selone complexes are reported.	selone	72-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-25
26859480-2	2016	Although Cu(i/ii), Co(ii), Ag(i), and Zn(ii) coordination to thione and selone ligands has been broadly studied and Fe(ii) plays an important role in oxidative damage, very few iron-thione complexes and no iron-selone complexes are reported.	selone	72-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-24
26859480-2	2016	Although Cu(i/ii), Co(ii), Ag(i), and Zn(ii) coordination to thione and selone ligands has been broadly studied and Fe(ii) plays an important role in oxidative damage, very few iron-thione complexes and no iron-selone complexes are reported.	selone	72-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-24
26859480-6	2016	Thione and selone coordination to Fe(ii) lowers the Fe(ii/iii) reduction potential, with a greater decrease for Fe(ii)-bound dmise than Fe(ii)-bound dmit.	Thiones	0-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-39
26859480-6	2016	Thione and selone coordination to Fe(ii) lowers the Fe(ii/iii) reduction potential, with a greater decrease for Fe(ii)-bound dmise than Fe(ii)-bound dmit.	Thiones	0-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-57
26859480-6	2016	Thione and selone coordination to Fe(ii) lowers the Fe(ii/iii) reduction potential, with a greater decrease for Fe(ii)-bound dmise than Fe(ii)-bound dmit.	Thiones	0-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-57
26980433-4	2016	The expression of COX2 mRNA in platelets and its influences on the effect of aspirin was also investigated.	Aspirin	77-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-22
26859427-3	2016	Si@Co(OH)2 MWs were utilized as precursors to synthesize Si@CoX2 (X = S or Se) photocathodes.	Silicon	0-2	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-64
26859427-3	2016	Si@Co(OH)2 MWs were utilized as precursors to synthesize Si@CoX2 (X = S or Se) photocathodes.	Carbonic Acid	3-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-64
26859427-3	2016	Si@Co(OH)2 MWs were utilized as precursors to synthesize Si@CoX2 (X = S or Se) photocathodes.	Silicon	57-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-64
26859427-5	2016	The CoX2 outer shell served as cocatalyst to accelerate the kinetics of photogenerated electrons from the underlying Si MWs and reduce the recombination.	Silicon	117-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-8
26859427-6	2016	Moreover, the CoX2 layer completely deposited on the Si surface functioned as a passivation layer by decreasing the oxide formation on Si MWs during solar hydrogen evolution.	Silicon	53-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-18
26859427-6	2016	Moreover, the CoX2 layer completely deposited on the Si surface functioned as a passivation layer by decreasing the oxide formation on Si MWs during solar hydrogen evolution.	Oxides	116-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-18
26859427-6	2016	Moreover, the CoX2 layer completely deposited on the Si surface functioned as a passivation layer by decreasing the oxide formation on Si MWs during solar hydrogen evolution.	Silicon	135-137	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-18
26859427-6	2016	Moreover, the CoX2 layer completely deposited on the Si surface functioned as a passivation layer by decreasing the oxide formation on Si MWs during solar hydrogen evolution.	Hydrogen	155-163	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-18
26859324-1	2016	Aspirin and other nonsteroidal anti-inflammatory drugs target the cyclooxygenase enzymes (COX-1 and COX-2) to block the formation of prostaglandins.	Aspirin	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-105
26660642-16	2016	At 72 h, serelaxin treatment improved bradykinin-mediated relaxation through COX2-derived PGI2 production.	serelaxin protein, human	9-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-81
26660642-16	2016	At 72 h, serelaxin treatment improved bradykinin-mediated relaxation through COX2-derived PGI2 production.	Epoprostenol	90-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-81
26685098-4	2016	But COX-2 products may not be all bad: prostanoids can exert anti-inflammatory/bronchoprotective functions in airways in addition to their pro-inflammatory actions.	Prostaglandins	39-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
26685098-7	2016	Evidence suggests that prostanoids produced via COX-2 upregulation show diverse actions (and herein we focus on prostaglandin E2 as a key example); these can be either beneficial or deleterious and their impact on respiratory disease can be dictated by local concentration and specific interaction with individual receptors.	Prostaglandins	23-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-53
26685098-7	2016	Evidence suggests that prostanoids produced via COX-2 upregulation show diverse actions (and herein we focus on prostaglandin E2 as a key example); these can be either beneficial or deleterious and their impact on respiratory disease can be dictated by local concentration and specific interaction with individual receptors.	Dinoprostone	112-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-53
26745504-8	2016	GlcN downregulated excessive expression of pro-inflammatory markers and promoted filopodia formation through NFkappaB/COX-2 inhibition in PAF-stimulated HMO6 cells.	Glucosamine	0-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-123
26166140-2	2016	BACKGROUND: RCT studies report that COX-2 selective inhibitor celecoxib induces fewer small intestinal injuries than nonselective nonsteroidal anti-inflammatory drugs (NSAIDs).	Celecoxib	62-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-41
26928048-6	2016	The gene expression analysis of arachidonate COX pathway revealed that the transcript levels of inducible COX-2, membrane-bound PGE synthase-1, and PGF synthase declined more greatly in cultured preadipocytes treated with AA.	Arachidonic Acid	32-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-111
27241143-9	2016	:  CONCLUSION: Through the inhibitory effect on EGFR-TPK, APN and MMP-2, osthole can decrease COX-2, VEGF and NF-kappaB expression while increase the activity of caspase-3, eventually blocking the growth and invasion of bladder cancer cell.	osthol	73-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-99
26909823-1	2016	The single molecule conductances of a series of bis-2,2":6",2""-terpyridine complexes featuring Ru(II), Fe(II), and Co(II) metal ions and trimethylsilylethynyl (Me3SiC C-) or thiomethyl (MeS-) surface contact groups have been determined.	bis-2,2":6",2""-terpyridine	48-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-122
26777227-2	2016	In this study, we describe the successful demonstration of the water- and temperature-triggered reversible structural transformation between cubane- and planar-type tetranuclear Co(II) cores sandwiched by polyoxometalates.	Water	63-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	178-184
26820843-5	2016	The complexation of labile Co(II) ions with the ligands afforded the macrocycle with four-fold rotational symmetry, exhibiting the right-angled geometries of the beta-diketonate ligands on the carbazole.	beta-diketonate	162-177	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-33
26820843-5	2016	The complexation of labile Co(II) ions with the ligands afforded the macrocycle with four-fold rotational symmetry, exhibiting the right-angled geometries of the beta-diketonate ligands on the carbazole.	carbazole	193-202	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-33
26820843-6	2016	The subsequent oxidation of the Co(II) ions inside the macrocycle into Co(III) ions made the metal-ligand bonds almost inert, thus affording a kinetically locked 4 : 4 metallomacrocycle.	co(iii)	71-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-38
26820843-6	2016	The subsequent oxidation of the Co(II) ions inside the macrocycle into Co(III) ions made the metal-ligand bonds almost inert, thus affording a kinetically locked 4 : 4 metallomacrocycle.	Metals	93-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-38
26762192-1	2016	IC50 values were obtained for two series of isoindolines derived from alpha-amino acids over cyclooxygenase 1 and 2 (COX-1 and COX-2).	isoindolines	44-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	127-132
26762192-3	2016	The model probed whether the COX-1 and COX-2 inhibitory activities of the isoindolines correlate with steric, hydrophobic, and thermodynamic parameters.	isoindolines	74-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-44
26762192-5	2016	In conclusion, the data suggests that the physicochemical descriptors evaluated have an impact on the inhibitory activity and selectivity of isoindolines over COX-1 and COX-2.	isoindolines	141-153	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	169-174
26859324-1	2016	Aspirin and other nonsteroidal anti-inflammatory drugs target the cyclooxygenase enzymes (COX-1 and COX-2) to block the formation of prostaglandins.	Prostaglandins	133-147	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-105
26859324-3	2016	Acetylation of COX-1 leads to complete loss of activity, while acetylation of COX-2 results in the generation of the monooxygenated product 15(R)-hydroxyeicosatetraenoic acid (15R-HETE).	(r)-hydroxyeicosatetraenoic acid	142-174	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-83
26859324-3	2016	Acetylation of COX-1 leads to complete loss of activity, while acetylation of COX-2 results in the generation of the monooxygenated product 15(R)-hydroxyeicosatetraenoic acid (15R-HETE).	15R-HETE	176-184	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-83
26859324-5	2016	We determined the crystal structures of S530T murine (mu) COX-2, aspirin-acetylated human (hu) COX-2, and huCOX-2 in complex with salicylate to 1.9, 2.0, and 2.4 A, respectively.	Aspirin	65-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-100
26859324-5	2016	We determined the crystal structures of S530T murine (mu) COX-2, aspirin-acetylated human (hu) COX-2, and huCOX-2 in complex with salicylate to 1.9, 2.0, and 2.4 A, respectively.	Salicylates	130-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-100
26859324-7	2016	On the basis of these structural observations, along with functional analysis of the S530T/G533V double mutant, we propose a working hypothesis for the generation of 15R-HETE by aspirin-acetylated COX-2.	15R-HETE	166-174	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	197-202
26859324-7	2016	On the basis of these structural observations, along with functional analysis of the S530T/G533V double mutant, we propose a working hypothesis for the generation of 15R-HETE by aspirin-acetylated COX-2.	Aspirin	178-185	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	197-202
26859480-6	2016	Thione and selone coordination to Fe(ii) lowers the Fe(ii/iii) reduction potential, with a greater decrease for Fe(ii)-bound dmise than Fe(ii)-bound dmit.	selone	11-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-39
26859480-6	2016	Thione and selone coordination to Fe(ii) lowers the Fe(ii/iii) reduction potential, with a greater decrease for Fe(ii)-bound dmise than Fe(ii)-bound dmit.	selone	11-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-57
26859480-6	2016	Thione and selone coordination to Fe(ii) lowers the Fe(ii/iii) reduction potential, with a greater decrease for Fe(ii)-bound dmise than Fe(ii)-bound dmit.	selone	11-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-57
26859480-6	2016	Thione and selone coordination to Fe(ii) lowers the Fe(ii/iii) reduction potential, with a greater decrease for Fe(ii)-bound dmise than Fe(ii)-bound dmit.	selone	11-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-57
26859480-7	2016	Dmit and dmise ligand-based oxidation potentials also significantly increase upon Fe(ii) binding compared, indicating that bound thione and selone ligands will undergo oxidation prior to Fe(ii).	dmit	0-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-87
26859480-7	2016	Dmit and dmise ligand-based oxidation potentials also significantly increase upon Fe(ii) binding compared, indicating that bound thione and selone ligands will undergo oxidation prior to Fe(ii).	dmit	0-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	190-192
26859480-7	2016	Dmit and dmise ligand-based oxidation potentials also significantly increase upon Fe(ii) binding compared, indicating that bound thione and selone ligands will undergo oxidation prior to Fe(ii).	DMISe	9-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-87
26859480-7	2016	Dmit and dmise ligand-based oxidation potentials also significantly increase upon Fe(ii) binding compared, indicating that bound thione and selone ligands will undergo oxidation prior to Fe(ii).	Thiones	129-135	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-87
26859480-7	2016	Dmit and dmise ligand-based oxidation potentials also significantly increase upon Fe(ii) binding compared, indicating that bound thione and selone ligands will undergo oxidation prior to Fe(ii).	Thiones	129-135	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	190-192
26859480-7	2016	Dmit and dmise ligand-based oxidation potentials also significantly increase upon Fe(ii) binding compared, indicating that bound thione and selone ligands will undergo oxidation prior to Fe(ii).	selone	140-146	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-87
26859480-7	2016	Dmit and dmise ligand-based oxidation potentials also significantly increase upon Fe(ii) binding compared, indicating that bound thione and selone ligands will undergo oxidation prior to Fe(ii).	selone	140-146	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	190-192
26758420-8	2016	Thus, our data show that HSCs are required for MDSC accumulation mediated by the COX2-PGE2-EP4 pathway, and these data are the first to link HSC and MDSC subsets in HCC immune microenvironment and provide a rationale for targeting PGE2 signaling for HCC therapy.	Dinoprostone	86-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-85
26440049-0	2016	Alpha-linolenic acid regulates Cox2/VEGF/MAP kinase pathway and decreases the expression of HPV oncoproteins E6/E7 through restoration of p53 and Rb expression in human cervical cancer cell lines.	alpha-Linolenic Acid	0-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-35
26440049-5	2016	Besides this, ALA significantly decreased the expression of phosphorylated p38, pERK1/2, c-JUN, NFkappaB, and COX2, proteins.	alpha-Linolenic Acid	14-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-114
26950454-11	2016	Caspase-3 and COX-2 dependent molecular targets seem to be involved in mediating the anti-proliferative effects of IM and CX combination.	Celecoxib	122-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
27006821-3	2016	In the complex cation, the Co(II) ion is octa-hedrally coordinated by two N,O,O"-tridentate TEA mol-ecules with a facial distribution and the N atoms in a trans arrangement.	triethanolamine	92-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-33
27006821-4	2016	Two ethanol groups of each TEA mol-ecule form two five-membered chelate rings around the Co(II) ion, while the third ethanol group does not coordinate to the metal.	Ethanol	4-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-95
26895946-9	2016	CONCLUSION: The biological processes induced by Wnt-5a in hippocampal neurons, involve the regulation of several miRNAs including miR-101b, which has the capacity to regulate several targets, including COX-2 in the central nervous system.	101b	134-138	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	202-207
26896068-9	2016	Moreover, metformin enhanced the anti-inflammatory effect of 5-ASA by decreasing the gene expression of IL-1beta, IL-6, COX-2 and TNF-alpha and its receptors; TNF-R1 and TNF-R2.	Metformin	10-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-125
26896068-9	2016	Moreover, metformin enhanced the anti-inflammatory effect of 5-ASA by decreasing the gene expression of IL-1beta, IL-6, COX-2 and TNF-alpha and its receptors; TNF-R1 and TNF-R2.	Mesalamine	61-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-125
26774035-0	2016	Synthesis and biological evaluation of fluorinated 1,5-diarylpyrrole-3-alkoxyethyl ether derivatives as selective COX-2 inhibitors endowed with anti-inflammatory activity.	1,5-diarylpyrrole-3-alkoxyethyl ether	51-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-119
26907236-2	2016	In the pursuit of employing ortho-YH substituted (Y = O, NH) aryl azides in Co(II) porphyrin-catalyzed nitrene transfer reactions, unexpected hydrogen atom transfer (HAT) from the OH or NH2 group in the ortho-position to the nitrene moiety of the key radical-intermediate was observed.	H-TYR-HIS-OH	34-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-82
26907236-2	2016	In the pursuit of employing ortho-YH substituted (Y = O, NH) aryl azides in Co(II) porphyrin-catalyzed nitrene transfer reactions, unexpected hydrogen atom transfer (HAT) from the OH or NH2 group in the ortho-position to the nitrene moiety of the key radical-intermediate was observed.	aryl azides	61-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-82
26799113-0	2016	Oxygen Activation by Co(II) and a Redox Non-Innocent Ligand: Spectroscopic Characterization of a Radical-Co(II)-Superoxide Complex with Divergent Catalytic Reactivity.	Oxygen	0-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-27
26799113-0	2016	Oxygen Activation by Co(II) and a Redox Non-Innocent Ligand: Spectroscopic Characterization of a Radical-Co(II)-Superoxide Complex with Divergent Catalytic Reactivity.	Oxygen	0-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-111
26799113-0	2016	Oxygen Activation by Co(II) and a Redox Non-Innocent Ligand: Spectroscopic Characterization of a Radical-Co(II)-Superoxide Complex with Divergent Catalytic Reactivity.	Superoxides	112-122	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-27
26799113-0	2016	Oxygen Activation by Co(II) and a Redox Non-Innocent Ligand: Spectroscopic Characterization of a Radical-Co(II)-Superoxide Complex with Divergent Catalytic Reactivity.	Superoxides	112-122	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-111
26669719-4	2016	Here we show that yeast Coa6 is an orthologue of human COA6, and like Cox2, is regulated by copper availability, further implicating it in copper delivery to Cox2.	Copper	92-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-74
26669719-4	2016	Here we show that yeast Coa6 is an orthologue of human COA6, and like Cox2, is regulated by copper availability, further implicating it in copper delivery to Cox2.	Copper	92-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	158-162
26669719-4	2016	Here we show that yeast Coa6 is an orthologue of human COA6, and like Cox2, is regulated by copper availability, further implicating it in copper delivery to Cox2.	Copper	139-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-74
26669719-4	2016	Here we show that yeast Coa6 is an orthologue of human COA6, and like Cox2, is regulated by copper availability, further implicating it in copper delivery to Cox2.	Copper	139-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	158-162
26757444-0	2016	A Mononuclear Co(II) Coordination Complex Locked in a Confined Space and Acting as an Electrochemical Water-Oxidation Catalyst: A "Ship-in-a-Bottle" Approach.	Water	102-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
26757444-4	2016	In the crystal structure of Co-WOC-1, a mononuclear Co(II) complex {Co(H2O)4(DMF)2}(2+) is encapsulated in the void space of a 3D framework structure and this translationally rigid complex cation is responsible for a remarkable electrocatalytic WO activity, with a catalytic turnover frequency (TOF) of 0.05 s(-1) at an overpotential of 390 mV (vs. NHE) in 0.1 m KOH along with prolonged stability.	co(h2o)4(dmf)2	68-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-57
26757444-4	2016	In the crystal structure of Co-WOC-1, a mononuclear Co(II) complex {Co(H2O)4(DMF)2}(2+) is encapsulated in the void space of a 3D framework structure and this translationally rigid complex cation is responsible for a remarkable electrocatalytic WO activity, with a catalytic turnover frequency (TOF) of 0.05 s(-1) at an overpotential of 390 mV (vs. NHE) in 0.1 m KOH along with prolonged stability.	potassium hydroxide	363-366	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-57
26647310-7	2016	The failure in tRNA(Tyr) metabolism impaired mitochondrial translation, especially for polypeptides with high content of tyrosine codon such as ND4, ND5, ND6 and COX2 in cells lines carrying homozygous YARS2 p.191Gly>Val and m.11778G>A mutations.	Tyrosine	20-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	162-166
26790581-3	2016	The probe was designed as the Co(II) complex of a cyanine dye, which shows a turn-on fluorescence signal based on a histamine-induced coordination displacement mechanism.	thionine	50-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-36
26790581-3	2016	The probe was designed as the Co(II) complex of a cyanine dye, which shows a turn-on fluorescence signal based on a histamine-induced coordination displacement mechanism.	Histamine	116-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-36
26846498-0	2016	Two-dimensional Zn(II) and one-dimensional Co(II) coordination polymers based on benzene-1,4-dicarboxylate and pyridine ligands.	1,4-benzenedicarboxylate	81-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
26846498-0	2016	Two-dimensional Zn(II) and one-dimensional Co(II) coordination polymers based on benzene-1,4-dicarboxylate and pyridine ligands.	pyridine	111-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
26846498-8	2016	The Co(II) cations are bridged by BDC(2-) ligands and are octahedrally coordinated by three carboxylate O atoms from three BDC(2-) ligands, one water O atom and two pyridine N atoms.	bdc(2-)	34-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
26846498-8	2016	The Co(II) cations are bridged by BDC(2-) ligands and are octahedrally coordinated by three carboxylate O atoms from three BDC(2-) ligands, one water O atom and two pyridine N atoms.	carboxylate	92-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
26846498-8	2016	The Co(II) cations are bridged by BDC(2-) ligands and are octahedrally coordinated by three carboxylate O atoms from three BDC(2-) ligands, one water O atom and two pyridine N atoms.	bdc(2-)	123-130	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
26846498-8	2016	The Co(II) cations are bridged by BDC(2-) ligands and are octahedrally coordinated by three carboxylate O atoms from three BDC(2-) ligands, one water O atom and two pyridine N atoms.	Water	144-149	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
26846498-8	2016	The Co(II) cations are bridged by BDC(2-) ligands and are octahedrally coordinated by three carboxylate O atoms from three BDC(2-) ligands, one water O atom and two pyridine N atoms.	pyridine n	165-175	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
26846500-0	2016	Bis(triethanolamine)bis(mu2-trimesato)dicobalt(II): a Co(II) dimer with an unreported two-dimensional supramolecular topology formed from triethanolamine and trimesic acid ligands.	bis(triethanolamine)bis(mu2-trimesato)dicobalt	0-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-60
26846500-0	2016	Bis(triethanolamine)bis(mu2-trimesato)dicobalt(II): a Co(II) dimer with an unreported two-dimensional supramolecular topology formed from triethanolamine and trimesic acid ligands.	triethanolamine	4-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-60
26846500-0	2016	Bis(triethanolamine)bis(mu2-trimesato)dicobalt(II): a Co(II) dimer with an unreported two-dimensional supramolecular topology formed from triethanolamine and trimesic acid ligands.	trimesic acid	158-171	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-60
26561742-0	2016	Design, synthesis and biological screening of new 4-thiazolidinone derivatives with promising COX-2 selectivity, anti-inflammatory activity and gastric safety profile.	4-thiazolidinone	50-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-99
26828949-2	2016	Compared to the precursor complex [Co5Cl4(Me2bta)6], which contains one Co(II) ion in octahedral and four Co(II) ions in tetrahedral coordination geometry, the title compound features all five Co(II) ions in an octahedral coordination environment while keeping a high complex symmetry.	co5cl4	35-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-78
26828949-2	2016	Compared to the precursor complex [Co5Cl4(Me2bta)6], which contains one Co(II) ion in octahedral and four Co(II) ions in tetrahedral coordination geometry, the title compound features all five Co(II) ions in an octahedral coordination environment while keeping a high complex symmetry.	co5cl4	35-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-112
26828949-2	2016	Compared to the precursor complex [Co5Cl4(Me2bta)6], which contains one Co(II) ion in octahedral and four Co(II) ions in tetrahedral coordination geometry, the title compound features all five Co(II) ions in an octahedral coordination environment while keeping a high complex symmetry.	co5cl4	35-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-112
26828949-2	2016	Compared to the precursor complex [Co5Cl4(Me2bta)6], which contains one Co(II) ion in octahedral and four Co(II) ions in tetrahedral coordination geometry, the title compound features all five Co(II) ions in an octahedral coordination environment while keeping a high complex symmetry.	me2bta)6	42-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-78
26828949-2	2016	Compared to the precursor complex [Co5Cl4(Me2bta)6], which contains one Co(II) ion in octahedral and four Co(II) ions in tetrahedral coordination geometry, the title compound features all five Co(II) ions in an octahedral coordination environment while keeping a high complex symmetry.	me2bta)6	42-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-112
26828949-2	2016	Compared to the precursor complex [Co5Cl4(Me2bta)6], which contains one Co(II) ion in octahedral and four Co(II) ions in tetrahedral coordination geometry, the title compound features all five Co(II) ions in an octahedral coordination environment while keeping a high complex symmetry.	me2bta)6	42-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-112
26828949-6	2016	The magnetic properties of here reported novel complex [Co5Tp*4(Me2bta)6] as well as its precursor [Co5Cl4(Me2bta)6] were examined in detail via ESR and SQUID measurements, which indicated weak anti-ferromagnetic exchange interactions between high-spin Co(II) centers at T &lt; 20 and 50 K, respectively.	co5tp*4(me2bta)6	56-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	253-259
26828949-6	2016	The magnetic properties of here reported novel complex [Co5Tp*4(Me2bta)6] as well as its precursor [Co5Cl4(Me2bta)6] were examined in detail via ESR and SQUID measurements, which indicated weak anti-ferromagnetic exchange interactions between high-spin Co(II) centers at T &lt; 20 and 50 K, respectively.	co5cl4(me2bta)6	100-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	253-259
26691217-2	2016	The aim of this study was to assess the effects of CUGBP2-mediated post-transcriptional regulation of COX-2 and HO-1 in pancreatic cancer cells in regard of response to gemcitabine (GEM) treatment.	gemcitabine	169-180	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-107
26691217-9	2016	Induction of CUGBP2 expression by curcumin resulted in the downregulation of HO-1 and COX-2 and strongly sensitized tumor cells to GEM treatment.	Curcumin	34-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-91
26677076-2	2016	Polyunsaturated fatty acids (PUFA) metabolism impaired by cyclooxygenases (COX-1, COX-2), which are responsible for formation of several eicosanoids, and by lipoxygenases (LOXs) that catalyze the addition of oxygen to linolenic, arachidonic (AA), and docosahexaenoic acids (DHA) and other PUFA leading to formation of bioactive lipids, significantly affects the course of neurodegenerative diseases.	Fatty Acids, Unsaturated	0-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
26677076-2	2016	Polyunsaturated fatty acids (PUFA) metabolism impaired by cyclooxygenases (COX-1, COX-2), which are responsible for formation of several eicosanoids, and by lipoxygenases (LOXs) that catalyze the addition of oxygen to linolenic, arachidonic (AA), and docosahexaenoic acids (DHA) and other PUFA leading to formation of bioactive lipids, significantly affects the course of neurodegenerative diseases.	Fatty Acids, Unsaturated	29-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
26677076-2	2016	Polyunsaturated fatty acids (PUFA) metabolism impaired by cyclooxygenases (COX-1, COX-2), which are responsible for formation of several eicosanoids, and by lipoxygenases (LOXs) that catalyze the addition of oxygen to linolenic, arachidonic (AA), and docosahexaenoic acids (DHA) and other PUFA leading to formation of bioactive lipids, significantly affects the course of neurodegenerative diseases.	Eicosanoids	137-148	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
26677076-2	2016	Polyunsaturated fatty acids (PUFA) metabolism impaired by cyclooxygenases (COX-1, COX-2), which are responsible for formation of several eicosanoids, and by lipoxygenases (LOXs) that catalyze the addition of oxygen to linolenic, arachidonic (AA), and docosahexaenoic acids (DHA) and other PUFA leading to formation of bioactive lipids, significantly affects the course of neurodegenerative diseases.	Oxygen	63-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
26677076-2	2016	Polyunsaturated fatty acids (PUFA) metabolism impaired by cyclooxygenases (COX-1, COX-2), which are responsible for formation of several eicosanoids, and by lipoxygenases (LOXs) that catalyze the addition of oxygen to linolenic, arachidonic (AA), and docosahexaenoic acids (DHA) and other PUFA leading to formation of bioactive lipids, significantly affects the course of neurodegenerative diseases.	linolenic	218-227	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
26677076-2	2016	Polyunsaturated fatty acids (PUFA) metabolism impaired by cyclooxygenases (COX-1, COX-2), which are responsible for formation of several eicosanoids, and by lipoxygenases (LOXs) that catalyze the addition of oxygen to linolenic, arachidonic (AA), and docosahexaenoic acids (DHA) and other PUFA leading to formation of bioactive lipids, significantly affects the course of neurodegenerative diseases.	Docosahexaenoic Acids	251-272	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
26677076-2	2016	Polyunsaturated fatty acids (PUFA) metabolism impaired by cyclooxygenases (COX-1, COX-2), which are responsible for formation of several eicosanoids, and by lipoxygenases (LOXs) that catalyze the addition of oxygen to linolenic, arachidonic (AA), and docosahexaenoic acids (DHA) and other PUFA leading to formation of bioactive lipids, significantly affects the course of neurodegenerative diseases.	Docosahexaenoic Acids	274-277	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
26677076-2	2016	Polyunsaturated fatty acids (PUFA) metabolism impaired by cyclooxygenases (COX-1, COX-2), which are responsible for formation of several eicosanoids, and by lipoxygenases (LOXs) that catalyze the addition of oxygen to linolenic, arachidonic (AA), and docosahexaenoic acids (DHA) and other PUFA leading to formation of bioactive lipids, significantly affects the course of neurodegenerative diseases.	Fatty Acids, Unsaturated	289-293	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
26768271-1	2016	NSAIDs exert their anti-inflammatory and analgesic effects by inhibition of COX-2, a key enzyme for proinflammatory prostanoid synthesis.	Prostaglandins	116-126	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-81
26929740-10	2016	Reagents which inhibit inflammation, such as the Cox2 inhibitor celecoxib, block the feed-forward loop and prevent induction of PDAC in models with endogenous oncogenic K-Ras(mt).	Celecoxib	64-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-53
26929740-10	2016	Reagents which inhibit inflammation, such as the Cox2 inhibitor celecoxib, block the feed-forward loop and prevent induction of PDAC in models with endogenous oncogenic K-Ras(mt).	pdac	128-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-53
26088701-4	2016	Notably, introduction of a nido-dicarbaborate cluster into the cyclooxygenase (COX) inhibitor indomethacin results in remarkably increased inhibitory potency and selectivity for COX-2 relative to the respective phenyl analogue.	nido	27-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	178-183
26088701-4	2016	Notably, introduction of a nido-dicarbaborate cluster into the cyclooxygenase (COX) inhibitor indomethacin results in remarkably increased inhibitory potency and selectivity for COX-2 relative to the respective phenyl analogue.	dicarbaborate	32-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	178-183
26088701-4	2016	Notably, introduction of a nido-dicarbaborate cluster into the cyclooxygenase (COX) inhibitor indomethacin results in remarkably increased inhibitory potency and selectivity for COX-2 relative to the respective phenyl analogue.	Indomethacin	94-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	178-183
26088701-5	2016	The first crystal structure of a carbaborane-containing inhibitor bound to COX-2 further reveals a novel binding mode for the inhibitor that is strikingly different from that of indomethacin.	carbaborane	33-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
26088701-5	2016	The first crystal structure of a carbaborane-containing inhibitor bound to COX-2 further reveals a novel binding mode for the inhibitor that is strikingly different from that of indomethacin.	Indomethacin	178-190	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
26716610-1	2016	Paramagnetic Fe(II) and Co(II) complexes are utilized as the first transition metal examples of (1)H NMR shift agents (paraSHIFT) for thermometry applications using Magnetic Resonance Spectroscopy (MRS).	Metals	78-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-30
26716610-3	2016	(1)H NMR spectra of the MPT- and TMPC-based Fe(II) and Co(II) complexes demonstrate narrow and highly shifted resonances that are dispersed as broadly as 440 ppm.	tmpc	33-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-61
26716610-3	2016	(1)H NMR spectra of the MPT- and TMPC-based Fe(II) and Co(II) complexes demonstrate narrow and highly shifted resonances that are dispersed as broadly as 440 ppm.	ammonium ferrous sulfate	44-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-61
26716933-10	2016	Metal-centered oxidations were exhibited for all of the Co(II) porphyrins and an M(II)/M(III) process was also observed to occur for NiOPP(R) (R = CH2OH, H, CHO, and NO2) and CuOPP(NO2)(CN)2.	Metals	0-5	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-61
27551490-9	2016	DBME also downregulated LPS-induced increased expression of iNOS, COX-2 and TNF-alpha along with suppression on intracellular ROS production that confirms the potential of DBME as anti-inflammatory extract.	dbme	0-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-71
26368802-0	2016	Mechanism of Co(II) adsorption by zero valent iron/graphene nanocomposite.	Iron	46-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-19
26368802-0	2016	Mechanism of Co(II) adsorption by zero valent iron/graphene nanocomposite.	Graphite	51-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-19
26368802-9	2016	The adsorption mechanism of Co(II) was attributed to inner-sphere complexation and dissolution/re-precipitation of the substituted metal oxides.	metal oxides	131-143	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-34
26454381-5	2016	The addition of Co(II) and Cu(II) solutions to the l-Tyr AgNPs also induces a paramagnetic quenching of the fluorescence in the PL spectra and the related Stern Volmer plots highlight a linear correlation over the whole concentration range for both metal ions, with a more pronounced effect for the copper(II) ion.	Tyrosine	53-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-22
26454381-5	2016	The addition of Co(II) and Cu(II) solutions to the l-Tyr AgNPs also induces a paramagnetic quenching of the fluorescence in the PL spectra and the related Stern Volmer plots highlight a linear correlation over the whole concentration range for both metal ions, with a more pronounced effect for the copper(II) ion.	Metals	249-254	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-22
26454381-5	2016	The addition of Co(II) and Cu(II) solutions to the l-Tyr AgNPs also induces a paramagnetic quenching of the fluorescence in the PL spectra and the related Stern Volmer plots highlight a linear correlation over the whole concentration range for both metal ions, with a more pronounced effect for the copper(II) ion.	cupric ion	299-309	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-22
26728231-3	2016	In compound 1, this approach reveals the correlation between the single-ion easy magnetization direction and a trigonal elongation axis of the Co(II) coordination octahedron.	octahedron	163-173	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	143-149
26823679-3	2016	DCF, which is a potent inhibitor of COX-2 and prostaglandin E2 synthesis, displays a range of effects on the immune system, the angiogenic cascade, chemo- and radio-sensitivity and tumour metabolism.	Diclofenac	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-41
26926362-8	2016	In the airways of COPD subjects, fibroblast-derived PGE2 may regulate angiogenesis and inflammation through the production of VEGF and IL-8 respectively, suggesting that the increase in expression of COX-2, EP2 and EP4 observed in COPD fibroblasts may contribute to steering the role of PGE2 from homeostatic to pro-inflammatory.	Dinoprostone	52-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	200-205
26926362-8	2016	In the airways of COPD subjects, fibroblast-derived PGE2 may regulate angiogenesis and inflammation through the production of VEGF and IL-8 respectively, suggesting that the increase in expression of COX-2, EP2 and EP4 observed in COPD fibroblasts may contribute to steering the role of PGE2 from homeostatic to pro-inflammatory.	Dinoprostone	287-291	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	200-205
26632201-5	2016	PGE2 appearing at this sub-mucosal level is a product of arachidonic acid metabolism mediated by type-2 cyclooxygenase (COX-2) situated on the membrane of many immune cells.	Dinoprostone	0-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-125
26632201-5	2016	PGE2 appearing at this sub-mucosal level is a product of arachidonic acid metabolism mediated by type-2 cyclooxygenase (COX-2) situated on the membrane of many immune cells.	Arachidonic Acid	57-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-125
26632201-7	2016	This inhibitory action of acetaminophen on COX2 only relates to physiological, low arachidonic acid concentrations.	Acetaminophen	26-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-47
26632201-7	2016	This inhibitory action of acetaminophen on COX2 only relates to physiological, low arachidonic acid concentrations.	Arachidonic Acid	83-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-47
26632201-11	2016	Several recent epidemiological studies have also reported on the magnitude of acetaminophen and ibuprofen exposure in children and the increase in immune deviations, it is important to better understand the potential negative impact of repeated inhibitions of prostaglandin synthesis by COX2s during infancy.	Prostaglandins	260-273	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	287-291
26723906-0	2016	Synthesis of dihydropyrazole sulphonamide derivatives that act as anti-cancer agents through COX-2 inhibition.	dihydropyrazole sulphonamide	13-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-98
26674056-0	2016	Phenolate based metallomacrocyclic xanthate complexes of Co(II)/Cu(II) and their exclusive deployment in [2 : 2] binuclear N,O-Schiff base macrocycle formation and in vitro anticancer studies.	phenoxy radical	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-63
26674056-0	2016	Phenolate based metallomacrocyclic xanthate complexes of Co(II)/Cu(II) and their exclusive deployment in [2 : 2] binuclear N,O-Schiff base macrocycle formation and in vitro anticancer studies.	cu(ii)	64-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-63
26674056-0	2016	Phenolate based metallomacrocyclic xanthate complexes of Co(II)/Cu(II) and their exclusive deployment in [2 : 2] binuclear N,O-Schiff base macrocycle formation and in vitro anticancer studies.	n,o-schiff base	123-138	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-63
26754960-1	2016	The generation, under self-assembly conditions, of coordination polymers on surface based combinations of a terpyridine-antracene-pyridine based tecton and Co(II) or Pd(II) cations is primarily governed by the coordination geometry of the metal center (octahedral and square planar respectively).	Polymers	64-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	156-162
26754960-1	2016	The generation, under self-assembly conditions, of coordination polymers on surface based combinations of a terpyridine-antracene-pyridine based tecton and Co(II) or Pd(II) cations is primarily governed by the coordination geometry of the metal center (octahedral and square planar respectively).	Metals	239-244	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	156-162
26701372-2	2016	Depending on the electronic effects of the substituents on the ligand, the redox of the metal center was systematically modulated, and the magnetic behavior from essentially high-spin Co(II) in 3 versus completely diamagnetic Co(III) in 1 to Co(II) spin-crossover in 2 can be achieved.	Metals	88-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	184-190
26704937-2	2016	Neutralization of the carboxylic acid moiety of the NSAID indomethacin to an ester or amide functionality confers COX-2 selectivity, but the molecular basis for this selectivity has not been completely revealed through mutagenesis studies and/or X-ray crystallographic attempts.	Carboxylic Acids	22-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-119
26704937-2	2016	Neutralization of the carboxylic acid moiety of the NSAID indomethacin to an ester or amide functionality confers COX-2 selectivity, but the molecular basis for this selectivity has not been completely revealed through mutagenesis studies and/or X-ray crystallographic attempts.	Indomethacin	58-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-119
26704937-2	2016	Neutralization of the carboxylic acid moiety of the NSAID indomethacin to an ester or amide functionality confers COX-2 selectivity, but the molecular basis for this selectivity has not been completely revealed through mutagenesis studies and/or X-ray crystallographic attempts.	Esters	77-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-119
26704937-2	2016	Neutralization of the carboxylic acid moiety of the NSAID indomethacin to an ester or amide functionality confers COX-2 selectivity, but the molecular basis for this selectivity has not been completely revealed through mutagenesis studies and/or X-ray crystallographic attempts.	Amides	86-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-119
26704937-3	2016	We expressed and assayed a number of divergent secondary shell COX-2 active site mutants and found that a COX-2 to COX-1 change at position 472 (Leu in COX-2, Met in COX-1) reduced the potency of enzyme inhibition by a series of COX-2-selective indomethacin amides and esters.	Leucine	145-148	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-68
26704937-3	2016	We expressed and assayed a number of divergent secondary shell COX-2 active site mutants and found that a COX-2 to COX-1 change at position 472 (Leu in COX-2, Met in COX-1) reduced the potency of enzyme inhibition by a series of COX-2-selective indomethacin amides and esters.	Leucine	145-148	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-111
26704937-3	2016	We expressed and assayed a number of divergent secondary shell COX-2 active site mutants and found that a COX-2 to COX-1 change at position 472 (Leu in COX-2, Met in COX-1) reduced the potency of enzyme inhibition by a series of COX-2-selective indomethacin amides and esters.	Leucine	145-148	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-111
26704937-3	2016	We expressed and assayed a number of divergent secondary shell COX-2 active site mutants and found that a COX-2 to COX-1 change at position 472 (Leu in COX-2, Met in COX-1) reduced the potency of enzyme inhibition by a series of COX-2-selective indomethacin amides and esters.	Leucine	145-148	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-111
26704937-3	2016	We expressed and assayed a number of divergent secondary shell COX-2 active site mutants and found that a COX-2 to COX-1 change at position 472 (Leu in COX-2, Met in COX-1) reduced the potency of enzyme inhibition by a series of COX-2-selective indomethacin amides and esters.	Indomethacin	245-257	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-68
26704937-3	2016	We expressed and assayed a number of divergent secondary shell COX-2 active site mutants and found that a COX-2 to COX-1 change at position 472 (Leu in COX-2, Met in COX-1) reduced the potency of enzyme inhibition by a series of COX-2-selective indomethacin amides and esters.	Indomethacin	245-257	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-111
26704937-3	2016	We expressed and assayed a number of divergent secondary shell COX-2 active site mutants and found that a COX-2 to COX-1 change at position 472 (Leu in COX-2, Met in COX-1) reduced the potency of enzyme inhibition by a series of COX-2-selective indomethacin amides and esters.	Indomethacin	245-257	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-111
26704937-3	2016	We expressed and assayed a number of divergent secondary shell COX-2 active site mutants and found that a COX-2 to COX-1 change at position 472 (Leu in COX-2, Met in COX-1) reduced the potency of enzyme inhibition by a series of COX-2-selective indomethacin amides and esters.	Indomethacin	245-257	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-111
26704937-3	2016	We expressed and assayed a number of divergent secondary shell COX-2 active site mutants and found that a COX-2 to COX-1 change at position 472 (Leu in COX-2, Met in COX-1) reduced the potency of enzyme inhibition by a series of COX-2-selective indomethacin amides and esters.	Amides	258-264	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-68
26704937-3	2016	We expressed and assayed a number of divergent secondary shell COX-2 active site mutants and found that a COX-2 to COX-1 change at position 472 (Leu in COX-2, Met in COX-1) reduced the potency of enzyme inhibition by a series of COX-2-selective indomethacin amides and esters.	Amides	258-264	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-111
26704937-3	2016	We expressed and assayed a number of divergent secondary shell COX-2 active site mutants and found that a COX-2 to COX-1 change at position 472 (Leu in COX-2, Met in COX-1) reduced the potency of enzyme inhibition by a series of COX-2-selective indomethacin amides and esters.	Amides	258-264	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-111
26704937-3	2016	We expressed and assayed a number of divergent secondary shell COX-2 active site mutants and found that a COX-2 to COX-1 change at position 472 (Leu in COX-2, Met in COX-1) reduced the potency of enzyme inhibition by a series of COX-2-selective indomethacin amides and esters.	Amides	258-264	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-111
26704937-3	2016	We expressed and assayed a number of divergent secondary shell COX-2 active site mutants and found that a COX-2 to COX-1 change at position 472 (Leu in COX-2, Met in COX-1) reduced the potency of enzyme inhibition by a series of COX-2-selective indomethacin amides and esters.	Esters	269-275	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-68
26704937-3	2016	We expressed and assayed a number of divergent secondary shell COX-2 active site mutants and found that a COX-2 to COX-1 change at position 472 (Leu in COX-2, Met in COX-1) reduced the potency of enzyme inhibition by a series of COX-2-selective indomethacin amides and esters.	Esters	269-275	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-111
26704937-3	2016	We expressed and assayed a number of divergent secondary shell COX-2 active site mutants and found that a COX-2 to COX-1 change at position 472 (Leu in COX-2, Met in COX-1) reduced the potency of enzyme inhibition by a series of COX-2-selective indomethacin amides and esters.	Esters	269-275	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-111
26704937-3	2016	We expressed and assayed a number of divergent secondary shell COX-2 active site mutants and found that a COX-2 to COX-1 change at position 472 (Leu in COX-2, Met in COX-1) reduced the potency of enzyme inhibition by a series of COX-2-selective indomethacin amides and esters.	Esters	269-275	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-111
26691756-0	2016	Synthesis, cyclooxygenase inhibition, anti-inflammatory evaluation and ulcerogenic liability of new 1,3,5-triarylpyrazoline and 1,5-diarylpyrazole derivatives as selective COX-2 inhibitors.	1,3,5-triarylpyrazoline	100-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	172-177
26691756-0	2016	Synthesis, cyclooxygenase inhibition, anti-inflammatory evaluation and ulcerogenic liability of new 1,3,5-triarylpyrazoline and 1,5-diarylpyrazole derivatives as selective COX-2 inhibitors.	1,5-diarylpyrazole	128-146	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	172-177
26586210-3	2016	We found that in primary human amniocytes, Atosiban (10 muM) signals via PTX-sensitive Galphai to activate transcription factor NF-kappaB p65, ERK1/2, and p38 which subsequently drives upregulation of the prostaglandin synthesis enzymes, COX-2 and phospho-cPLA2 and excretion of prostaglandins (PGE2) (n = 6; p &lt; 0.05, ANOVA).	atosiban	43-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	238-243
26586210-3	2016	We found that in primary human amniocytes, Atosiban (10 muM) signals via PTX-sensitive Galphai to activate transcription factor NF-kappaB p65, ERK1/2, and p38 which subsequently drives upregulation of the prostaglandin synthesis enzymes, COX-2 and phospho-cPLA2 and excretion of prostaglandins (PGE2) (n = 6; p &lt; 0.05, ANOVA).	ptx	73-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	238-243
26586210-3	2016	We found that in primary human amniocytes, Atosiban (10 muM) signals via PTX-sensitive Galphai to activate transcription factor NF-kappaB p65, ERK1/2, and p38 which subsequently drives upregulation of the prostaglandin synthesis enzymes, COX-2 and phospho-cPLA2 and excretion of prostaglandins (PGE2) (n = 6; p &lt; 0.05, ANOVA).	galphai	87-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	238-243
30979111-2	2016	Although the work herein reported is focused upon a particular kind of coordination polymer ([M(mu-ox)(4-apy)2]n, M: Co(II), Ni(II)), the results are of interest in the field of porous materials and of MOFs, as the employed synthetic approach implies that any coordination polymer could be processable as a mesoporous material.	Polymers	84-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-123
26498361-1	2016	OBJECTIVES: This review stated the possible application of the active components of licorice, glycyrrhizin (GL) and glycyrrhetinic acid (GA), in rheumatoid arthritis (RA) treatment based on the cyclooxygenase (COX)-2/thromboxane A2 (TxA2) pathway.	Glycyrrhizic Acid	94-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	194-216
26498361-1	2016	OBJECTIVES: This review stated the possible application of the active components of licorice, glycyrrhizin (GL) and glycyrrhetinic acid (GA), in rheumatoid arthritis (RA) treatment based on the cyclooxygenase (COX)-2/thromboxane A2 (TxA2) pathway.	Glycyrrhizic Acid	108-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	194-216
26498361-1	2016	OBJECTIVES: This review stated the possible application of the active components of licorice, glycyrrhizin (GL) and glycyrrhetinic acid (GA), in rheumatoid arthritis (RA) treatment based on the cyclooxygenase (COX)-2/thromboxane A2 (TxA2) pathway.	Glycyrrhetinic Acid	116-135	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	194-216
26498361-1	2016	OBJECTIVES: This review stated the possible application of the active components of licorice, glycyrrhizin (GL) and glycyrrhetinic acid (GA), in rheumatoid arthritis (RA) treatment based on the cyclooxygenase (COX)-2/thromboxane A2 (TxA2) pathway.	Glycyrrhetinic Acid	137-139	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	194-216
26498361-3	2016	RESULTS: The active components of licorice GL and GA exert the potential anti-inflammatory effects through, at least in part, suppressing COX-2 and its downstream product TxA2.	Glycyrrhizic Acid	43-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	138-143
26498361-3	2016	RESULTS: The active components of licorice GL and GA exert the potential anti-inflammatory effects through, at least in part, suppressing COX-2 and its downstream product TxA2.	Glycyrrhetinic Acid	50-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	138-143
26498361-7	2016	CONCLUSIONS: The active components of licorice, GL and GA, could not only potentiate the therapeutic effects but also decrease the adverse effects of NSAIDs or DMARDs through suppressing the COX-2/TxA2 pathway during treatment course of RA.	Glycyrrhizic Acid	48-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	191-196
26498361-7	2016	CONCLUSIONS: The active components of licorice, GL and GA, could not only potentiate the therapeutic effects but also decrease the adverse effects of NSAIDs or DMARDs through suppressing the COX-2/TxA2 pathway during treatment course of RA.	Glycyrrhetinic Acid	55-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	191-196
26691217-2	2016	The aim of this study was to assess the effects of CUGBP2-mediated post-transcriptional regulation of COX-2 and HO-1 in pancreatic cancer cells in regard of response to gemcitabine (GEM) treatment.	gemcitabine	182-185	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-107
26970793-1	2016	The ion-associated complex formed between anionic chelate of Co(II)-4-(2-Thiazolylazo)resorcinol (TAR) with the monotetrazolium cation of 2-(4-Iodophenyl)-3-(4-nitrophenyl)-5-phenyl-2H-tetrazolium chloride (INT) in the liquid-liquid extraction system Co(II)-TAR-INT-H(2)O-CHCl(3) was studied by the spectrophotometric method.	tar	98-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-67
26517522-3	2016	Lovastatin inhibited the expressions of transforming growth factor (TGF)-beta1, cyclooxygenase (COX)-2, and intercellular adhesion molecule (ICAM)-1.	Lovastatin	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-102
26517522-5	2016	While Lovastatin"s inhibitory effects on TGFbeta1, COX2, and ICAM-1 expression were independently controlled by the tumor suppressor LKB1, integrin beta3 expression was not affected.	Lovastatin	6-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-55
26870577-1	2016	The asymmetric unit of the title polymer, [Co2(C3H3O4)2Cl2(H2O)2] n , comprises one Co(II) atom, one water mol-ecule, one singly deprotonated malonic acid mol-ecule (HMal(-); systematic name 2-carb-oxy-acetate) and one Cl(-) anion.	[co2(c3h3o4)2cl2(h2o)2] n	42-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-90
26970793-1	2016	The ion-associated complex formed between anionic chelate of Co(II)-4-(2-Thiazolylazo)resorcinol (TAR) with the monotetrazolium cation of 2-(4-Iodophenyl)-3-(4-nitrophenyl)-5-phenyl-2H-tetrazolium chloride (INT) in the liquid-liquid extraction system Co(II)-TAR-INT-H(2)O-CHCl(3) was studied by the spectrophotometric method.	tar	98-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	251-257
26870577-2	2016	The Co(II) atom is octa-hedrally coordinated by the O atom of a water mol-ecule, by one terminally bound carboxyl-ate O atom of an HMal(-) anion and by two O atoms of a chelating HMal(-) anion, as well as by two Cl(-) anions.	Water	64-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
26870577-2	2016	The Co(II) atom is octa-hedrally coordinated by the O atom of a water mol-ecule, by one terminally bound carboxyl-ate O atom of an HMal(-) anion and by two O atoms of a chelating HMal(-) anion, as well as by two Cl(-) anions.	carboxyl-ate o	105-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
26870577-2	2016	The Co(II) atom is octa-hedrally coordinated by the O atom of a water mol-ecule, by one terminally bound carboxyl-ate O atom of an HMal(-) anion and by two O atoms of a chelating HMal(-) anion, as well as by two Cl(-) anions.	Anions	135-144	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
26870577-2	2016	The Co(II) atom is octa-hedrally coordinated by the O atom of a water mol-ecule, by one terminally bound carboxyl-ate O atom of an HMal(-) anion and by two O atoms of a chelating HMal(-) anion, as well as by two Cl(-) anions.	Anions	183-192	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
26870577-3	2016	The Cl(-) anions bridge two Co(II) atoms, forming a centrosymmetric Co2Cl2 core.	co2cl2	68-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-34
26970793-1	2016	The ion-associated complex formed between anionic chelate of Co(II)-4-(2-Thiazolylazo)resorcinol (TAR) with the monotetrazolium cation of 2-(4-Iodophenyl)-3-(4-nitrophenyl)-5-phenyl-2H-tetrazolium chloride (INT) in the liquid-liquid extraction system Co(II)-TAR-INT-H(2)O-CHCl(3) was studied by the spectrophotometric method.	monotetrazolium	112-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-67
26870577-4	2016	Each malonate ligand is involved in the formation of six-membered chelate rings involving one Co(II) atom of the dinuclear unit and at the same time is coordinating to another Co(II) atom of a neighbouring dinuclear unit in a bridging mode.	malonic acid	5-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-100
26970793-1	2016	The ion-associated complex formed between anionic chelate of Co(II)-4-(2-Thiazolylazo)resorcinol (TAR) with the monotetrazolium cation of 2-(4-Iodophenyl)-3-(4-nitrophenyl)-5-phenyl-2H-tetrazolium chloride (INT) in the liquid-liquid extraction system Co(II)-TAR-INT-H(2)O-CHCl(3) was studied by the spectrophotometric method.	monotetrazolium	112-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	251-257
26870577-4	2016	Each malonate ligand is involved in the formation of six-membered chelate rings involving one Co(II) atom of the dinuclear unit and at the same time is coordinating to another Co(II) atom of a neighbouring dinuclear unit in a bridging mode.	malonic acid	5-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	176-182
26970793-1	2016	The ion-associated complex formed between anionic chelate of Co(II)-4-(2-Thiazolylazo)resorcinol (TAR) with the monotetrazolium cation of 2-(4-Iodophenyl)-3-(4-nitrophenyl)-5-phenyl-2H-tetrazolium chloride (INT) in the liquid-liquid extraction system Co(II)-TAR-INT-H(2)O-CHCl(3) was studied by the spectrophotometric method.	iodonitrotetrazolium	138-205	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-67
26970793-1	2016	The ion-associated complex formed between anionic chelate of Co(II)-4-(2-Thiazolylazo)resorcinol (TAR) with the monotetrazolium cation of 2-(4-Iodophenyl)-3-(4-nitrophenyl)-5-phenyl-2H-tetrazolium chloride (INT) in the liquid-liquid extraction system Co(II)-TAR-INT-H(2)O-CHCl(3) was studied by the spectrophotometric method.	iodonitrotetrazolium	138-205	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	251-257
26970793-1	2016	The ion-associated complex formed between anionic chelate of Co(II)-4-(2-Thiazolylazo)resorcinol (TAR) with the monotetrazolium cation of 2-(4-Iodophenyl)-3-(4-nitrophenyl)-5-phenyl-2H-tetrazolium chloride (INT) in the liquid-liquid extraction system Co(II)-TAR-INT-H(2)O-CHCl(3) was studied by the spectrophotometric method.	iodonitrotetrazolium	207-210	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-67
26970793-1	2016	The ion-associated complex formed between anionic chelate of Co(II)-4-(2-Thiazolylazo)resorcinol (TAR) with the monotetrazolium cation of 2-(4-Iodophenyl)-3-(4-nitrophenyl)-5-phenyl-2H-tetrazolium chloride (INT) in the liquid-liquid extraction system Co(II)-TAR-INT-H(2)O-CHCl(3) was studied by the spectrophotometric method.	h(2)o-chcl	266-276	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-67
26098693-5	2016	S1P significantly enhanced COX-2 expression and PGE2 secretion, and this was repressed by the selective COX-2 inhibitor celecoxib, the corticosteroid dexamethasone, or small interfering RNA (siRNA) knockdown of COX-2 expression.	Dinoprostone	48-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
30979108-1	2016	A series of iminopyridine ligated Co(II) (1a-7a) and Ni(II) (1b-7b) complexes were synthesized.	Aminopyridines	12-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-40
26098693-5	2016	S1P significantly enhanced COX-2 expression and PGE2 secretion, and this was repressed by the selective COX-2 inhibitor celecoxib, the corticosteroid dexamethasone, or small interfering RNA (siRNA) knockdown of COX-2 expression.	Dinoprostone	48-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
26098693-5	2016	S1P significantly enhanced COX-2 expression and PGE2 secretion, and this was repressed by the selective COX-2 inhibitor celecoxib, the corticosteroid dexamethasone, or small interfering RNA (siRNA) knockdown of COX-2 expression.	Celecoxib	120-129	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-32
26098693-5	2016	S1P significantly enhanced COX-2 expression and PGE2 secretion, and this was repressed by the selective COX-2 inhibitor celecoxib, the corticosteroid dexamethasone, or small interfering RNA (siRNA) knockdown of COX-2 expression.	Celecoxib	120-129	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
26098693-5	2016	S1P significantly enhanced COX-2 expression and PGE2 secretion, and this was repressed by the selective COX-2 inhibitor celecoxib, the corticosteroid dexamethasone, or small interfering RNA (siRNA) knockdown of COX-2 expression.	Celecoxib	120-129	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
26098693-8	2016	Taken together, these data indicate that S1P represses beta2-adrenergic activity in ASM cells by increasing COX-2-mediated PGE2 production, and suggest that this bioactive sphingolipid found elevated in asthma may contribute to beta2-adrenergic desensitization.	Dinoprostone	123-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-113
26098693-8	2016	Taken together, these data indicate that S1P represses beta2-adrenergic activity in ASM cells by increasing COX-2-mediated PGE2 production, and suggest that this bioactive sphingolipid found elevated in asthma may contribute to beta2-adrenergic desensitization.	Sphingolipids	172-184	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-113
27324742-3	2016	METHODS: A series of 3-arylidene-5-(naphthalene-2-yl)-furan-2(3H)-ones (2a-j) were synthesized by incorporating pharmacophore of COX-2 inhibitor rofecoxib and naphthyl ring of naproxen as potential non steroidal anti-inflammatory agents.	3-arylidene-5-(naphthalene-2-yl)-furan-2	21-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-134
27324742-3	2016	METHODS: A series of 3-arylidene-5-(naphthalene-2-yl)-furan-2(3H)-ones (2a-j) were synthesized by incorporating pharmacophore of COX-2 inhibitor rofecoxib and naphthyl ring of naproxen as potential non steroidal anti-inflammatory agents.	3h)-ones	62-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-134
27324742-3	2016	METHODS: A series of 3-arylidene-5-(naphthalene-2-yl)-furan-2(3H)-ones (2a-j) were synthesized by incorporating pharmacophore of COX-2 inhibitor rofecoxib and naphthyl ring of naproxen as potential non steroidal anti-inflammatory agents.	rofecoxib	145-154	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-134
27324742-3	2016	METHODS: A series of 3-arylidene-5-(naphthalene-2-yl)-furan-2(3H)-ones (2a-j) were synthesized by incorporating pharmacophore of COX-2 inhibitor rofecoxib and naphthyl ring of naproxen as potential non steroidal anti-inflammatory agents.	Naproxen	176-184	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-134
27221835-0	2016	Celecoxib, a COX-2 Selective Inhibitor, Induces Cell Cycle Arrest at the G2/M Phase in HeLa Cervical Cancer Cells.	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
27221835-1	2016	Celecoxib, a selective inhibitor of COX-2, showed cytotoxic effects in many cancer cell lines including cervical cancer cells.	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-41
27022316-3	2016	The specific configuration of the alpha-amino acid group affects the eg (1) electron of Co(II) transfer to the pi (*) orbit of O2; this phenomenon also favors the reversible formation and dissociation of Co-O2 bond when O2 coordinates with Co(II) complexes.	Oxygen	207-209	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	240-246
27022316-3	2016	The specific configuration of the alpha-amino acid group affects the eg (1) electron of Co(II) transfer to the pi (*) orbit of O2; this phenomenon also favors the reversible formation and dissociation of Co-O2 bond when O2 coordinates with Co(II) complexes.	Oxygen	207-209	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-94
27022316-3	2016	The specific configuration of the alpha-amino acid group affects the eg (1) electron of Co(II) transfer to the pi (*) orbit of O2; this phenomenon also favors the reversible formation and dissociation of Co-O2 bond when O2 coordinates with Co(II) complexes.	Oxygen	207-209	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	240-246
27648004-0	2016	Reversible Oxygenation of 2,4-Diaminobutanoic Acid-Co(II) Complexes.	2,4-diaminobutyric acid	26-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-57
27648004-1	2016	This paper introduces the structural characterization and studies on reversible oxygenation behavior of a new oxygen carrier Co(II)-2,4-diaminobutanoic acid (DABA) complex in aqueous solution.	Oxygen	80-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-131
27648004-1	2016	This paper introduces the structural characterization and studies on reversible oxygenation behavior of a new oxygen carrier Co(II)-2,4-diaminobutanoic acid (DABA) complex in aqueous solution.	daba)	158-163	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-131
27648004-4	2016	This complex can maintain 50% of its original oxygenation capacity after 30 cycles in 24 h and retain 5% of the original oxygenation capacity after more than 260 cycles after 72 h. When a ligand analogue was linked to histidine (His), the new complex exhibited as excellent reversible oxygenation property as His-Co(II) complex.	Histidine	218-227	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	313-319
27648004-4	2016	This complex can maintain 50% of its original oxygenation capacity after 30 cycles in 24 h and retain 5% of the original oxygenation capacity after more than 260 cycles after 72 h. When a ligand analogue was linked to histidine (His), the new complex exhibited as excellent reversible oxygenation property as His-Co(II) complex.	Histidine	229-232	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	313-319
27648004-4	2016	This complex can maintain 50% of its original oxygenation capacity after 30 cycles in 24 h and retain 5% of the original oxygenation capacity after more than 260 cycles after 72 h. When a ligand analogue was linked to histidine (His), the new complex exhibited as excellent reversible oxygenation property as His-Co(II) complex.	Histidine	309-312	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	313-319
27698647-0	2016	Novel FeII and CoII Complexes of Natural Product Tryptanthrin: Synthesis and Binding with G-Quadruplex DNA.	tryptanthrine	49-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-19
27698647-3	2016	Two novel FeII and CoII complexes of tryptanthrin were first synthesized.	tryptanthrine	37-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-23
26785683-0	2016	Ester Prodrugs of Ketoprofen: Synthesis, In Vitro Stability, In Vivo Biological Evaluation and In Silico Comparative Docking Studies Against COX-1 and COX-2.	Esters	0-5	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-156
26785683-0	2016	Ester Prodrugs of Ketoprofen: Synthesis, In Vitro Stability, In Vivo Biological Evaluation and In Silico Comparative Docking Studies Against COX-1 and COX-2.	Ketoprofen	18-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-156
26503024-12	2016	Our findings indicate that COX-2/PGE2 may be associated with the MCA occlusion and the hemorrhagic stroke in patients with MMD.	Dinoprostone	33-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-32
30568809-1	2016	PURPOSE: The main objective of this study was the comparison of the influence for three non-steroidal anti-inflammatory drugs (NSAIDs) belonging to the oxicam class, namely piroxicam and tenoxicam, as non-selective inhibitors of cyclooxygenase (COX), and meloxicam, a selective COX-2 inhibitor, on glutathione peroxidase (GPx) activity in patients with osteoarthritis of the knee.	tenoxicam	187-196	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	278-283
26474693-1	2016	It has been demonstrated that COX-2-selective inhibitor celecoxib shows synergy with oxaliplatin for suppressing tumor growth.	Celecoxib	56-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-35
26474693-1	2016	It has been demonstrated that COX-2-selective inhibitor celecoxib shows synergy with oxaliplatin for suppressing tumor growth.	Oxaliplatin	85-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-35
26634864-8	2016	Naproxen sodium significantly decreased PGE2 secretion (p &lt; 0.01) and COX-2 mRNA expression (p &lt; 0.01).	Naproxen	0-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-78
26634864-9	2016	TNF-alpha induced PGE2 release was reduced in presence of naproxen sodium (p &lt; 0.05), in association with decreased COX-2 and increased HPDG mRNAs expression.	Dinoprostone	18-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-124
26634864-9	2016	TNF-alpha induced PGE2 release was reduced in presence of naproxen sodium (p &lt; 0.05), in association with decreased COX-2 and increased HPDG mRNAs expression.	Naproxen	58-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-124
26634864-10	2016	Naproxen sodium decreases endometrial PGE2 release induced by inflammatory stimulus acting on endometrial COX-2 and HPDG expression, suggesting endometrial synthesis of prostaglandins as a possible target for reduction of uterine inflammatory mechanism in dysmenorrhea.	Naproxen	0-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-111
26634864-10	2016	Naproxen sodium decreases endometrial PGE2 release induced by inflammatory stimulus acting on endometrial COX-2 and HPDG expression, suggesting endometrial synthesis of prostaglandins as a possible target for reduction of uterine inflammatory mechanism in dysmenorrhea.	Dinoprostone	38-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-111
27610157-0	2016	Design, Synthesis and Biological Evaluation of4-(Imidazolylmethyl)-2-(4-methylsulfonyl phenyl)-Quinoline Derivatives as Selective COX-2 Inhibitors and In-vitro Anti-breast Cancer Agents.	-(imidazolylmethyl)-2-(4-methylsulfonyl phenyl)-quinoline	47-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	130-135
27022316-1	2016	We systematically investigated the reversibility, time lapse, and oxygenation-deoxygenation properties of 15 natural alpha-amino acid-Co(II) complexes through UV-vis spectrophotometer, polarographic oxygen electrode, and DFT calculations, respectively, to explore the relationship between the coordinating structure and reversible oxygenation of alpha-amino acid-Co(II) complexes.	Amino Acids	117-133	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-140
27022316-1	2016	We systematically investigated the reversibility, time lapse, and oxygenation-deoxygenation properties of 15 natural alpha-amino acid-Co(II) complexes through UV-vis spectrophotometer, polarographic oxygen electrode, and DFT calculations, respectively, to explore the relationship between the coordinating structure and reversible oxygenation of alpha-amino acid-Co(II) complexes.	Amino Acids	117-133	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	363-369
27022316-1	2016	We systematically investigated the reversibility, time lapse, and oxygenation-deoxygenation properties of 15 natural alpha-amino acid-Co(II) complexes through UV-vis spectrophotometer, polarographic oxygen electrode, and DFT calculations, respectively, to explore the relationship between the coordinating structure and reversible oxygenation of alpha-amino acid-Co(II) complexes.	Oxygen	66-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-140
27022316-1	2016	We systematically investigated the reversibility, time lapse, and oxygenation-deoxygenation properties of 15 natural alpha-amino acid-Co(II) complexes through UV-vis spectrophotometer, polarographic oxygen electrode, and DFT calculations, respectively, to explore the relationship between the coordinating structure and reversible oxygenation of alpha-amino acid-Co(II) complexes.	Amino Acids	346-362	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-140
27022316-3	2016	The specific configuration of the alpha-amino acid group affects the eg (1) electron of Co(II) transfer to the pi (*) orbit of O2; this phenomenon also favors the reversible formation and dissociation of Co-O2 bond when O2 coordinates with Co(II) complexes.	Oxygen	127-129	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-94
27022316-3	2016	The specific configuration of the alpha-amino acid group affects the eg (1) electron of Co(II) transfer to the pi (*) orbit of O2; this phenomenon also favors the reversible formation and dissociation of Co-O2 bond when O2 coordinates with Co(II) complexes.	Oxygen	127-129	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	240-246
27022316-3	2016	The specific configuration of the alpha-amino acid group affects the eg (1) electron of Co(II) transfer to the pi (*) orbit of O2; this phenomenon also favors the reversible formation and dissociation of Co-O2 bond when O2 coordinates with Co(II) complexes.	Cobalt	88-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	240-246
27022316-3	2016	The specific configuration of the alpha-amino acid group affects the eg (1) electron of Co(II) transfer to the pi (*) orbit of O2; this phenomenon also favors the reversible formation and dissociation of Co-O2 bond when O2 coordinates with Co(II) complexes.	Oxygen	207-209	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-94
26545354-1	2016	The compound N-(2-hydroxybenzylidene)-1-ethyl-1, 4-dihydro-7-methyl-4-oxo-1, 8 naphthyridine-3-carbohydrazide (LH) and its Cu (II), Co (II) and Zn (II) complexes were synthesized and characterized.	N-(2-hydroxybenzylidene)-1-ethyl-1, 4-dihydro-7-methyl-4-oxo-1, 8 naphthyridine-3-carbohydrazide	13-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-151
26560040-0	2016	Low E-prostanoid 2 receptor levels and deficient induction of the IL-1beta/IL-1 type I receptor/COX-2 pathway: Vicious circle in patients with aspirin-exacerbated respiratory disease.	Aspirin	143-150	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-101
26560040-1	2016	BACKGROUND: We hypothesized that the 2 reported alterations in aspirin-exacerbated respiratory disease (AERD), reduced expression/production of COX-2/prostaglandin (PG) E2 and diminished expression of E-prostanoid (EP) 2 receptor, are closely linked.	Aspirin	63-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	144-149
26560040-1	2016	BACKGROUND: We hypothesized that the 2 reported alterations in aspirin-exacerbated respiratory disease (AERD), reduced expression/production of COX-2/prostaglandin (PG) E2 and diminished expression of E-prostanoid (EP) 2 receptor, are closely linked.	prostaglandin (pg) e2	150-171	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	144-149
27232977-3	2016	The structure of the TBZA, and its Co(II) and Cu(II) complexes, was determined by X-ray diffraction methods.	tbza	21-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-41
26545354-1	2016	The compound N-(2-hydroxybenzylidene)-1-ethyl-1, 4-dihydro-7-methyl-4-oxo-1, 8 naphthyridine-3-carbohydrazide (LH) and its Cu (II), Co (II) and Zn (II) complexes were synthesized and characterized.	Luteinizing Hormone	111-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-151
29912514-6	2016	Nepafenac shows high selectivity and activity against COX-2 isoform, the key enzyme implicated in inducing inflammation, which is the main cause of macular edema.	nepafenac	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-59
26410343-4	2016	We found that Tyr and OA significantly inhibited TNF-alpha-induced COX-2 gene and protein expression, as well as PGE2 secretion.	4-hydroxyphenylethanol	14-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-72
26834307-4	2016	The separation of Co(II) from Zn(II), Ni(II) and Cu(II) was also studied, but the selective recovery of the metals was possible using the multi-stage stripping process.	Zinc	30-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-24
26834307-4	2016	The separation of Co(II) from Zn(II), Ni(II) and Cu(II) was also studied, but the selective recovery of the metals was possible using the multi-stage stripping process.	Nickel(2+)	38-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-24
26834307-4	2016	The separation of Co(II) from Zn(II), Ni(II) and Cu(II) was also studied, but the selective recovery of the metals was possible using the multi-stage stripping process.	cu(ii)	49-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-24
27843201-0	2016	Indoxyl Sulfate Induces Mesangial Cell Proliferation via the Induction of COX-2.	Indican	0-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
27630451-7	2016	In addition, we identified that the PGE2-limiting checkpoint downstream TLR3, TLR5, and TLR7 was a defect in COX2 induction, while TLR1/2 and TLR2/6 failed to mobilize arachidonic acid, the substrate for the COX2 enzyme.	Dinoprostone	36-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-113
27630451-7	2016	In addition, we identified that the PGE2-limiting checkpoint downstream TLR3, TLR5, and TLR7 was a defect in COX2 induction, while TLR1/2 and TLR2/6 failed to mobilize arachidonic acid, the substrate for the COX2 enzyme.	Dinoprostone	36-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	208-212
27843201-4	2016	COX-2 expression was examined by Western blotting and qRT-PCR, and a specific COX-2 inhibitor NS398 was applied to define its role in IS-induced MC proliferation.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	94-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-83
27843201-6	2016	Next, we found an inducible inflammation-related enzyme COX-2 was remarkably enhanced by IS, and the inhibition of COX-2 by NS398 significantly blocked IS-induced MC proliferation in line with a blockade of PGE2 production.	Indican	89-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-61
27843201-6	2016	Next, we found an inducible inflammation-related enzyme COX-2 was remarkably enhanced by IS, and the inhibition of COX-2 by NS398 significantly blocked IS-induced MC proliferation in line with a blockade of PGE2 production.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	124-129	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-120
27843201-6	2016	Next, we found an inducible inflammation-related enzyme COX-2 was remarkably enhanced by IS, and the inhibition of COX-2 by NS398 significantly blocked IS-induced MC proliferation in line with a blockade of PGE2 production.	Dinoprostone	207-211	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-61
27843201-6	2016	Next, we found an inducible inflammation-related enzyme COX-2 was remarkably enhanced by IS, and the inhibition of COX-2 by NS398 significantly blocked IS-induced MC proliferation in line with a blockade of PGE2 production.	Dinoprostone	207-211	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-120
27245906-2	2016	These neutral arachidonic acid (AA) derivatives have been identified as efficient substrates for the second isoform of the cyclooxygenase enzyme (COX-2).	Arachidonic Acid	14-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	146-151
27245906-3	2016	A diverse family of prostaglandin glycerol esters (PG-Gs) and prostaglandin ethanolamides (PG-EAs) is generated by the action of COX-2 (and downstream prostaglandin synthases) on 2-AG and AEA.	prostaglandin glycerol esters	20-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-134
27245906-3	2016	A diverse family of prostaglandin glycerol esters (PG-Gs) and prostaglandin ethanolamides (PG-EAs) is generated by the action of COX-2 (and downstream prostaglandin synthases) on 2-AG and AEA.	pg-gs	51-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-134
27245906-3	2016	A diverse family of prostaglandin glycerol esters (PG-Gs) and prostaglandin ethanolamides (PG-EAs) is generated by the action of COX-2 (and downstream prostaglandin synthases) on 2-AG and AEA.	prostaglandin ethanolamides	62-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-134
27245906-3	2016	A diverse family of prostaglandin glycerol esters (PG-Gs) and prostaglandin ethanolamides (PG-EAs) is generated by the action of COX-2 (and downstream prostaglandin synthases) on 2-AG and AEA.	pg-eas	91-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-134
27245906-3	2016	A diverse family of prostaglandin glycerol esters (PG-Gs) and prostaglandin ethanolamides (PG-EAs) is generated by the action of COX-2 (and downstream prostaglandin synthases) on 2-AG and AEA.	glyceryl 2-arachidonate	179-183	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-134
27245906-3	2016	A diverse family of prostaglandin glycerol esters (PG-Gs) and prostaglandin ethanolamides (PG-EAs) is generated by the action of COX-2 (and downstream prostaglandin synthases) on 2-AG and AEA.	anandamide	188-191	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-134
27156517-4	2016	However, because of their effectiveness in blocking PGE2 mediated inflammation, a key pathway that drives many diseases, there is a clear unmet medical need to develop new COX-2 inhibitors that are free of the aforementioned problems.	Dinoprostone	52-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	172-177
26870226-0	2016	Sinomenine, a COX-2 inhibitor, induces cell cycle arrest and inhibits growth of human colon carcinoma cells in vitro and in vivo.	sinomenine	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
26553519-0	2016	Hypertension: Haematopoietic COX-2 in salt-sensitive hypertension.	Salts	38-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34
26870226-8	2016	Our findings demonstrate that SIN inhibits the proliferation of SW1116 cells by promoting their accumulation in the G1 phase, with concomitant suppression of COX-2 expression.	sinomenine	30-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	158-163
26636181-3	2015	We have utilized double-quantum coherence (DQC) spectroscopy to determine the distance distributions between Tyr-385 and Tyr-504 radicals in COX-2.	Tyrosine	109-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	141-146
26245626-2	2016	Cobalt oxido catalyst (Co-OECs) films deposited from buffered Co(II) solutions have emerged as arguably the most studied class of heterogeneous oxygen evolution catalysts.	Cobalt	0-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-68
26636181-3	2015	We have utilized double-quantum coherence (DQC) spectroscopy to determine the distance distributions between Tyr-385 and Tyr-504 radicals in COX-2.	Tyrosine	121-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	141-146
26636181-4	2015	The distances obtained with DQC confirm that Tyr-385 and Tyr-504 radicals were generated in each monomer and accurately match the distances measured in COX-2 crystal structures.	Tyrosine	45-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-157
26636181-4	2015	The distances obtained with DQC confirm that Tyr-385 and Tyr-504 radicals were generated in each monomer and accurately match the distances measured in COX-2 crystal structures.	Tyrosine	57-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-157
26467233-1	2015	A heterometallic phenylsilsesquioxane [(PhSiO1,5)22(CoO)3(NaO0.5)6] (EtOH)6 (H2O) 1 cage architecture of Co(II) ions in a triangular topology exhibits a slow dynamic behavior in its magnetization, induced by the freezing of the spins of individual molecules.	Octaphenylsilsesquioxane	17-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-111
26636830-10	2015	Similar calculations for the six-coordinate neutral complexes [Co(II)(tpy( ))2](0) and [Co(II)(bpy( ))2(bpy(0))](0) point to a common S = (3)/2 ground state, each possessing a central high-spin Co(II) ion and two pi-radical anion ligands.	bpy(0))	104-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-94
26636830-10	2015	Similar calculations for the six-coordinate neutral complexes [Co(II)(tpy( ))2](0) and [Co(II)(bpy( ))2(bpy(0))](0) point to a common S = (3)/2 ground state, each possessing a central high-spin Co(II) ion and two pi-radical anion ligands.	bpy(0))	104-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-94
26546221-0	2015	Synthesis, cyclooxygenase inhibition, anti-inflammatory evaluation and ulcerogenic liability of novel triarylpyrazoline derivatives as selective COX-2 inhibitors.	triarylpyrazoline	102-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-150
26546221-1	2015	A new series of triarylpyrazoline derivatives 8a-p containing the most important COX-2 pharmacophore (SO2CH3 or/and SO2NH2) were synthesized by reaction of propen-1-one derivatives 6a-h with different phenyl hydrazine hydrochloride derivatives 7a-b in aqueous ethanol.	triarylpyrazoline	16-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-86
26546221-1	2015	A new series of triarylpyrazoline derivatives 8a-p containing the most important COX-2 pharmacophore (SO2CH3 or/and SO2NH2) were synthesized by reaction of propen-1-one derivatives 6a-h with different phenyl hydrazine hydrochloride derivatives 7a-b in aqueous ethanol.	8a-p	46-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-86
26546221-1	2015	A new series of triarylpyrazoline derivatives 8a-p containing the most important COX-2 pharmacophore (SO2CH3 or/and SO2NH2) were synthesized by reaction of propen-1-one derivatives 6a-h with different phenyl hydrazine hydrochloride derivatives 7a-b in aqueous ethanol.	so2ch3	102-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-86
26546221-1	2015	A new series of triarylpyrazoline derivatives 8a-p containing the most important COX-2 pharmacophore (SO2CH3 or/and SO2NH2) were synthesized by reaction of propen-1-one derivatives 6a-h with different phenyl hydrazine hydrochloride derivatives 7a-b in aqueous ethanol.	so2nh2	116-122	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-86
26546221-1	2015	A new series of triarylpyrazoline derivatives 8a-p containing the most important COX-2 pharmacophore (SO2CH3 or/and SO2NH2) were synthesized by reaction of propen-1-one derivatives 6a-h with different phenyl hydrazine hydrochloride derivatives 7a-b in aqueous ethanol.	phenylhydrazine	201-231	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-86
26546221-1	2015	A new series of triarylpyrazoline derivatives 8a-p containing the most important COX-2 pharmacophore (SO2CH3 or/and SO2NH2) were synthesized by reaction of propen-1-one derivatives 6a-h with different phenyl hydrazine hydrochloride derivatives 7a-b in aqueous ethanol.	Boron	141-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-86
26546221-1	2015	A new series of triarylpyrazoline derivatives 8a-p containing the most important COX-2 pharmacophore (SO2CH3 or/and SO2NH2) were synthesized by reaction of propen-1-one derivatives 6a-h with different phenyl hydrazine hydrochloride derivatives 7a-b in aqueous ethanol.	Ethanol	260-267	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-86
26498129-6	2015	ABSTRACT: The present study aimed to assess the effect of a 1-week high-salt (HS) diet on the role of cyclo-oxygenases (COX-1 and COX-2) and the vasoconstrictor prostaglandins, thromboxane A2 (TXA2 ) and prostaglandin F2alpha (PGF2alpha ), on skin microcirculatory blood flow, as well as to detect its effect on markers of endothelial activation such as soluble cell adhesion molecules.	hassio	78-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	130-135
26537572-2	2015	In an effort to access this unique combination of geometry and spin state, we report the synthesis of a series of M(II) compounds stabilized by a trianionic pincer-type ligand, highlighting the formation of a high-spin square-planar Co(II) complex.	m(ii)	114-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	233-239
26467233-1	2015	A heterometallic phenylsilsesquioxane [(PhSiO1,5)22(CoO)3(NaO0.5)6] (EtOH)6 (H2O) 1 cage architecture of Co(II) ions in a triangular topology exhibits a slow dynamic behavior in its magnetization, induced by the freezing of the spins of individual molecules.	phsio1	40-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-111
26548460-12	2015	30% yield) with respect to the instantaneous and quantitative conversion of Co(II)2SS into Co(III)I under similar conditions.	co(iii)i	91-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-81
26467233-1	2015	A heterometallic phenylsilsesquioxane [(PhSiO1,5)22(CoO)3(NaO0.5)6] (EtOH)6 (H2O) 1 cage architecture of Co(II) ions in a triangular topology exhibits a slow dynamic behavior in its magnetization, induced by the freezing of the spins of individual molecules.	carboxyl radical	52-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-111
26467233-1	2015	A heterometallic phenylsilsesquioxane [(PhSiO1,5)22(CoO)3(NaO0.5)6] (EtOH)6 (H2O) 1 cage architecture of Co(II) ions in a triangular topology exhibits a slow dynamic behavior in its magnetization, induced by the freezing of the spins of individual molecules.	nao0	58-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-111
26467233-1	2015	A heterometallic phenylsilsesquioxane [(PhSiO1,5)22(CoO)3(NaO0.5)6] (EtOH)6 (H2O) 1 cage architecture of Co(II) ions in a triangular topology exhibits a slow dynamic behavior in its magnetization, induced by the freezing of the spins of individual molecules.	Ethanol	69-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-111
26467233-1	2015	A heterometallic phenylsilsesquioxane [(PhSiO1,5)22(CoO)3(NaO0.5)6] (EtOH)6 (H2O) 1 cage architecture of Co(II) ions in a triangular topology exhibits a slow dynamic behavior in its magnetization, induced by the freezing of the spins of individual molecules.	Water	77-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-111
26540629-0	2015	Palbociclib inhibits epithelial-mesenchymal transition and metastasis in breast cancer via c-Jun/COX-2 signaling pathway.	palbociclib	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
26538114-0	2015	The electrochemical oxidation of toluene catalysed by Co(II) in N-butyl-N-methylpyrrolidinium bis(trifluoromethylsulfonyl)imide.	Toluene	33-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-60
26538114-0	2015	The electrochemical oxidation of toluene catalysed by Co(II) in N-butyl-N-methylpyrrolidinium bis(trifluoromethylsulfonyl)imide.	n-butyl-n-methylpyrrolidinium bis(trifluoromethylsulfonyl)imide	64-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-60
26538114-1	2015	The electrochemical oxidation of toluene in N-butyl-N-methylpyrrolidinium bis(trifluoromethylsulfonyl)imide ([bmpyr](+)[Ntf2](-)) was investigated by using cyclic voltammetry and galvanostatic electrolysis in the presence of Co(II) at a Pt disc working electrode.	Toluene	33-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	225-231
26538114-1	2015	The electrochemical oxidation of toluene in N-butyl-N-methylpyrrolidinium bis(trifluoromethylsulfonyl)imide ([bmpyr](+)[Ntf2](-)) was investigated by using cyclic voltammetry and galvanostatic electrolysis in the presence of Co(II) at a Pt disc working electrode.	n-butyl-n-methylpyrrolidinium bis(trifluoromethylsulfonyl)imide	44-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	225-231
26538114-1	2015	The electrochemical oxidation of toluene in N-butyl-N-methylpyrrolidinium bis(trifluoromethylsulfonyl)imide ([bmpyr](+)[Ntf2](-)) was investigated by using cyclic voltammetry and galvanostatic electrolysis in the presence of Co(II) at a Pt disc working electrode.	[bmpyr](+)[ntf2](-)	109-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	225-231
26538114-2	2015	Cyclic voltammetry (CV) investigations revealed that Co(II)-Co(III) oxidation is a diffusion controlled electron transfer process.	co(iii)	60-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-59
26538114-3	2015	The diffusion coefficient values of Co(II) were found to increase from 0.38 x 10(-7) to 1.9 x 10(-7) cm(2) s(-1) as the temperature was increased from 25  C to 80  C. The CV peak current for toluene electro-oxidation increased by nearly 7 fold in the presence of Co(II) demonstrating a good catalytic effect.	Toluene	191-198	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-42
26538114-4	2015	Co(II) catalysed galvanostatic electrolysis of toluene at room temperature has shown that benzaldehyde was formed along with a small quantity of 3-methyl-1-hexanol.	Toluene	47-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
26538114-4	2015	Co(II) catalysed galvanostatic electrolysis of toluene at room temperature has shown that benzaldehyde was formed along with a small quantity of 3-methyl-1-hexanol.	benzaldehyde	90-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
26538114-4	2015	Co(II) catalysed galvanostatic electrolysis of toluene at room temperature has shown that benzaldehyde was formed along with a small quantity of 3-methyl-1-hexanol.	3-METHYL-1-HEXANOL	145-163	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
26542630-1	2015	In our present work, magnetic cobalt ferrite (CoFe2O4) nanoparticles have been successfully synthesised by thermal decomposition of Fe(III) and Co(II) acetylacetonate compounds in organic solvents in the presence of oleic acid (OA)/ oleylamine (OLA) as surfactants and 1,2-hexadecanediol (HDD) or octadecanol (OCD-ol) as an accelerating agent.	cobalt ferrite	30-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	144-150
26542630-1	2015	In our present work, magnetic cobalt ferrite (CoFe2O4) nanoparticles have been successfully synthesised by thermal decomposition of Fe(III) and Co(II) acetylacetonate compounds in organic solvents in the presence of oleic acid (OA)/ oleylamine (OLA) as surfactants and 1,2-hexadecanediol (HDD) or octadecanol (OCD-ol) as an accelerating agent.	cobalt ferrite	46-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	144-150
26540629-7	2015	COX-2 was decreased after palbociclib treatment.	palbociclib	26-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
26540629-8	2015	The production of PGE2 was also reduced along with COX-2.	Dinoprostone	18-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-56
26697402-9	2015	PGE2 is produced downstream of caspase 3 and the cyclooxygenases COX1 and COX2, and we show that the pan COX1-2 inhibitor indomethacin blocks IR-induced PGE2 production in the presence or absence of DDR inhibitors.	Dinoprostone	0-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-78
26494320-0	2015	Six, Seven or Eight Coordinate Fe(II) , Co(II) or Ni(II) Complexes of Amide-Appended Tetraazamacrocycles for ParaCEST Thermometry.	Amides	70-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-46
26494320-0	2015	Six, Seven or Eight Coordinate Fe(II) , Co(II) or Ni(II) Complexes of Amide-Appended Tetraazamacrocycles for ParaCEST Thermometry.	tetraazamacrocycles	85-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-46
26494320-7	2015	For [Co(L2)](2+) , one structure has seven-coordinate Co(II) with three bound amide pendents and a second structure has a six-coordinate Co(II) with two bound amide pendents.	co(l2)	5-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-60
26494320-7	2015	For [Co(L2)](2+) , one structure has seven-coordinate Co(II) with three bound amide pendents and a second structure has a six-coordinate Co(II) with two bound amide pendents.	co(l2)	5-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-143
26697402-9	2015	PGE2 is produced downstream of caspase 3 and the cyclooxygenases COX1 and COX2, and we show that the pan COX1-2 inhibitor indomethacin blocks IR-induced PGE2 production in the presence or absence of DDR inhibitors.	Indomethacin	122-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-78
26697402-9	2015	PGE2 is produced downstream of caspase 3 and the cyclooxygenases COX1 and COX2, and we show that the pan COX1-2 inhibitor indomethacin blocks IR-induced PGE2 production in the presence or absence of DDR inhibitors.	Dinoprostone	153-157	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-78
26551030-6	2015	The TPAP ligand forms 6-membered chelate rings upon coordination and binds in the desired tetradentate fashion to a Co(II) ion.	tpap	4-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-122
26579729-2	2015	The Co(II) ions are bridged by the rod-like bmzbc(-) ligands to give a two-dimensional (2D) sheet wherein the Co(II) ions are spatially separated from each other by the long bmzbc(-) rods.	bmzbc	44-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
26551246-2	2015	Both Cu(II) and Cu(I) reagents were independently added to a Co(II) metalloligand to provide (py3tren)CoCuCl (1-Cl) and (py3tren)CoCu(CH3CN) (2-CH3CN), respectively, where py3tren is the triply deprotonated form of N,N,N-tris(2-(2-pyridylamino)ethyl)amine.	cu(ii)	5-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-67
26551246-2	2015	Both Cu(II) and Cu(I) reagents were independently added to a Co(II) metalloligand to provide (py3tren)CoCuCl (1-Cl) and (py3tren)CoCu(CH3CN) (2-CH3CN), respectively, where py3tren is the triply deprotonated form of N,N,N-tris(2-(2-pyridylamino)ethyl)amine.	cu(i) reagents	16-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-67
26551246-2	2015	Both Cu(II) and Cu(I) reagents were independently added to a Co(II) metalloligand to provide (py3tren)CoCuCl (1-Cl) and (py3tren)CoCu(CH3CN) (2-CH3CN), respectively, where py3tren is the triply deprotonated form of N,N,N-tris(2-(2-pyridylamino)ethyl)amine.	(py3tren)cocucl	93-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-67
26551246-2	2015	Both Cu(II) and Cu(I) reagents were independently added to a Co(II) metalloligand to provide (py3tren)CoCuCl (1-Cl) and (py3tren)CoCu(CH3CN) (2-CH3CN), respectively, where py3tren is the triply deprotonated form of N,N,N-tris(2-(2-pyridylamino)ethyl)amine.	1-cl	110-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-67
26551246-2	2015	Both Cu(II) and Cu(I) reagents were independently added to a Co(II) metalloligand to provide (py3tren)CoCuCl (1-Cl) and (py3tren)CoCu(CH3CN) (2-CH3CN), respectively, where py3tren is the triply deprotonated form of N,N,N-tris(2-(2-pyridylamino)ethyl)amine.	(py3tren)cocu(ch3cn)	120-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-67
26551246-2	2015	Both Cu(II) and Cu(I) reagents were independently added to a Co(II) metalloligand to provide (py3tren)CoCuCl (1-Cl) and (py3tren)CoCu(CH3CN) (2-CH3CN), respectively, where py3tren is the triply deprotonated form of N,N,N-tris(2-(2-pyridylamino)ethyl)amine.	2-ch3cn	142-149	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-67
26551246-2	2015	Both Cu(II) and Cu(I) reagents were independently added to a Co(II) metalloligand to provide (py3tren)CoCuCl (1-Cl) and (py3tren)CoCu(CH3CN) (2-CH3CN), respectively, where py3tren is the triply deprotonated form of N,N,N-tris(2-(2-pyridylamino)ethyl)amine.	py3tren	94-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-67
26551246-2	2015	Both Cu(II) and Cu(I) reagents were independently added to a Co(II) metalloligand to provide (py3tren)CoCuCl (1-Cl) and (py3tren)CoCu(CH3CN) (2-CH3CN), respectively, where py3tren is the triply deprotonated form of N,N,N-tris(2-(2-pyridylamino)ethyl)amine.	n,n,n-tris(2-(2-pyridylamino)ethyl)amine	215-255	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-67
26579729-2	2015	The Co(II) ions are bridged by the rod-like bmzbc(-) ligands to give a two-dimensional (2D) sheet wherein the Co(II) ions are spatially separated from each other by the long bmzbc(-) rods.	bmzbc	174-179	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
26579729-2	2015	The Co(II) ions are bridged by the rod-like bmzbc(-) ligands to give a two-dimensional (2D) sheet wherein the Co(II) ions are spatially separated from each other by the long bmzbc(-) rods.	bmzbc	174-179	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-116
26780018-5	2015	All eligible patients were given a COX-2 inhibitor--celecoxib 100 mg--twice daily starting on the day of surgery until the seventh day post-operatively or discharge, whichever was earlier.	Celecoxib	52-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40
26163790-1	2015	Two new mixed chelidamate complexes, [M(chel)(mhpOCH3) 2H2O] 2H2O [M=Ni(II) (1); Co(II) (2); chel: chelidamate or 4-hydroxypyridine-2,6-dicarboxylate; mhp: 4-methoxypyridine], were prepared and characterized through a combination of X-ray diffraction method, FT-IR and UV-Vis spectroscopy.	chelidamate	14-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-87
26524410-6	2015	At similar concentrations and 4h incubation, DAA-I increased the release of the 4 prostaglandins via the angiotensin AT1 receptor and COX-2, again mimicking the action of angiotensin II.	daa	45-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-139
26524410-6	2015	At similar concentrations and 4h incubation, DAA-I increased the release of the 4 prostaglandins via the angiotensin AT1 receptor and COX-2, again mimicking the action of angiotensin II.	Prostaglandins	82-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-139
26709467-5	2015	Findings show, for the first time, evidence of controlled optical recognition of Pd(II), Au(III), and Co(II) ions and a highly selective system for recovery of Pd(II) ions (up to ~95%) in ores and industrial wastes.	Polydioxanone	160-166	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-108
29861945-6	2015	Thus, this work should support an understanding of the possible mechanisms of the CoII/CoIII-catalyzed C(sp2)-H functionalization, and also provide an example of the rational design of novel catalytic reactions guided by theoretical calculations.	(sp2)	104-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-86
26462142-0	2015	New Coumarin Derivatives as Potent Selective COX-2 Inhibitors: Synthesis, Anti-Inflammatory, QSAR, and Molecular Modeling Studies.	coumarin	4-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-50
26462142-1	2015	Two new series of coumarin derivatives incorporating thiazoline and thiazolidinone moieties were designed, synthesized, and investigated in vivo for their anti-inflammatory activities using the carrageenan-induced rat paw edema model and in vitro for their inhibitory activities against the human cyclooxygenase (COX)-1 and COX-2 isoforms.	coumarin	18-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	324-329
26462142-3	2015	All the bioactive compounds showed in vitro high affinity and selectivity toward the COX-2 isoenzyme, compared to the reference celecoxib with IC50 values ranging from 0.31 to 0.78 muM.	Celecoxib	128-137	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-90
26462142-4	2015	The ethyl thiosemicarbazone 2b, thiazoline derivatives 3a, 3b, 5b, 6a, and 7f, and the thiazolidinone compounds 8b and 9a showed the highest in vivo and in vitro anti-inflammatory activities with remarkable COX-2 selectivity.	ethyl thiosemicarbazone	4-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	207-212
26462142-4	2015	The ethyl thiosemicarbazone 2b, thiazoline derivatives 3a, 3b, 5b, 6a, and 7f, and the thiazolidinone compounds 8b and 9a showed the highest in vivo and in vitro anti-inflammatory activities with remarkable COX-2 selectivity.	thiazolidinone	87-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	207-212
26904451-2	2015	Etoricoxib is a second-generation cox-2 inhibitor and as its use increases so do the reports of side effects.	Etoricoxib	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-39
25980490-3	2015	The cyclooxygenase enzymes (COX-1, COX-2) are the key enzymes in the conversion of arachidonic acid into prostaglandins.	Arachidonic Acid	83-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40
25980490-3	2015	The cyclooxygenase enzymes (COX-1, COX-2) are the key enzymes in the conversion of arachidonic acid into prostaglandins.	Prostaglandins	105-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40
25980490-4	2015	Prostaglandin E2 (PGE2), a key product of COX-2, has an immunomodulatory role.	Dinoprostone	0-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47
25980490-4	2015	Prostaglandin E2 (PGE2), a key product of COX-2, has an immunomodulatory role.	Dinoprostone	18-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47
25980490-12	2015	CONCLUSIONS: COX-2 and its product PGE2 are strongly expressed in LP skin lesions, indicating that they have a role in the pathogenesis of LP through their immunomodulatory effects.	Dinoprostone	35-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
25899770-2	2015	PATIENTS AND METHODS: Since March 2003, patients pathologically diagnosed with extraperitoneal desmoid tumors have been prospectively treated with meloxicam, a COX-2 inhibitor, at our institution.	Meloxicam	147-156	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	160-165
26156811-5	2015	The results demonstrated that thymoquinone concentration-dependently inhibited IL-1beta-induced COX-2, iNOS, NO, and PGE2 production.	thymoquinone	30-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-101
26407807-7	2015	Activation of AMPK, using two pharmacologically distinct compounds, AICAR or phenformin, significantly suppressed LPS- or IL-1beta-induced gene expression and secretion of pro-inflammatory cytokine IL-6, the chemokines IL-8 and MCP-1, and COX-2 and subsequent prostaglandin release from adipose tissue and skeletal muscle.	Phenformin	77-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	239-244
26590114-7	2015	Fisetin also inhibited the production of NO, PGE2 IL-1beta, IL-6, expression of iNOS and COX-2, and activation of NF-kappaB in HaCaT cells treated with TNF-alpha.	fisetin	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-94
26641550-10	2015	Through neutralization of IL-1beta or inhibition of COX2-PGE2 pathways, A2E-laden RPE cells expressed reduced effect in inducing Th1 cells.	Dinoprostone	57-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-56
27610157-1	2016	A new group of 4-(Imidazolylmethyl)quinoline derivatives possessing a methylsulfonyl COX-2 pharmacophore at the para position of the C-2 phenyl ring were designed and synthesized as selective COX-2 inhibitors and in-vitroanti breast cancer agents.	4-(imidazolylmethyl)quinoline	15-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-90
27610157-1	2016	A new group of 4-(Imidazolylmethyl)quinoline derivatives possessing a methylsulfonyl COX-2 pharmacophore at the para position of the C-2 phenyl ring were designed and synthesized as selective COX-2 inhibitors and in-vitroanti breast cancer agents.	4-(imidazolylmethyl)quinoline	15-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	192-197
27610157-3	2016	Molecular modeling studies indicated that the methylsulfonyl substituent can be inserted into the secondary pocket of COX-2 active site for interactions with Arg(513).	Arginine	158-161	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-123
27610157-6	2016	Among the quinolines 9a-e, 4-((1H-Imidazol-1-yl)methyl) 7,8,9,10-tetrahydro-2-(4-methylsulfonylphenyl)-benzo[h]quinoline (9d)was identified as the most potent andselective COX-2inhibitor as well as the most cytotoxic agent against MCF-7 cells.	Quinolines	10-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	172-177
27610157-6	2016	Among the quinolines 9a-e, 4-((1H-Imidazol-1-yl)methyl) 7,8,9,10-tetrahydro-2-(4-methylsulfonylphenyl)-benzo[h]quinoline (9d)was identified as the most potent andselective COX-2inhibitor as well as the most cytotoxic agent against MCF-7 cells.	9a-e	21-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	172-177
27610157-6	2016	Among the quinolines 9a-e, 4-((1H-Imidazol-1-yl)methyl) 7,8,9,10-tetrahydro-2-(4-methylsulfonylphenyl)-benzo[h]quinoline (9d)was identified as the most potent andselective COX-2inhibitor as well as the most cytotoxic agent against MCF-7 cells.	4-((1h-imidazol-1-yl)methyl) 7,8,9,10-tetrahydro-2-(4-methylsulfonylphenyl)-benzo[h]quinoline	27-120	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	172-177
26319435-10	2015	All 3 positional isomers of NOSH-aspirin preferentially inhibited COX-1 over COX-2.	Aspirin	33-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-82
26319435-5	2015	Since the parent compound aspirin, inhibits both COX-1 and COX-2, we also evaluated the effects of these compounds on COX-1 and COX-2 enzyme activities and also performed modeling of the interactions between the positional isomers of NOSH-aspirin and COX-1 and COX-2 enzymes.	Aspirin	26-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-64
26385185-0	2015	Induction of HO-1 by carbon monoxide releasing molecule-2 attenuates thrombin-induced COX-2 expression and hypertrophy in primary human cardiomyocytes.	Carbon Monoxide	21-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-91
26385185-5	2015	We found that thrombin-induced COX-2 expression, PGE2 release and cardiomyocyte hypertrophy markers (increase in ANF/BNP, alpha-actin expression and cell surface area) was attenuated by pretreatment with CORM-2 which was partially reversed by hemoglobin (Hb) or ZnPP (an inhibitor of HO-1 activity), suggesting that HO-1/CO system may be of clinical importance to ameliorate heart failure through inhibition of inflammatory responses.	zinc protoporphyrin	262-266	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-36
26440770-2	2015	Here, we predict that employing a ligand that forces a trigonal bipyramidal arrangement and has weak equatorial sigma-donating atoms, increases (in absolute value) the negative zero field splitting parameter D. With these considerations in mind, we used a sulfur containing ligand (NS3(iPr)), which imposes a trigonal bipyramidal geometry to the central Co(II) ion with long equatorial Co-S bonds.	Sulfur	256-262	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	354-360
26460817-3	2015	The results of the magnetic measurements displayed that ferromagnetic interactions occurred in the frameworks (3-7) containing "heavy" lanthanide ions (Gd, Tb, Dy, Ho, and Er), which should be ascribed to the coupling between the Ln(III) and Co(II) ions.	Lanthanoid Series Elements	135-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	242-248
26498167-4	2015	Specific responses in the lattice adjustment are detected for Co(II) in the octahedral and Pd(II) in the square planar positions.	Polydioxanone	91-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-68
26527363-2	2015	In the present study, feeding sows with betaine-supplemented diets throughout gestation significantly upregulated the expression of mtDNA-encoded OXPHOS genes (p &lt; 0.05), including COX1, COX2, and ND5, in the muscle of newborn piglets, which was associated with enhanced mitochondrial COX enzyme activity (p &lt; 0.05).	Betaine	40-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	190-194
27293584-4	2015	Herein we describe the stepwise optimisation of reaction parameters (pH, reagent concentrations and reaction time) for the room temperature, water-based synthesis of several members of the CPO-27/MOF-74-M series of MOFs, including ones made from Mg(II), Ni(II), Co(II) and Zn(II) ions.	Water	141-146	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	262-268
26600514-3	2015	In the present study, the ability of meloxicam, a COX-2-specific inhibitor to enhance doxorubicin-mediated inhibition was investigated in human A549 lung cancer in vivo and in vitro.	Meloxicam	37-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-55
26600514-3	2015	In the present study, the ability of meloxicam, a COX-2-specific inhibitor to enhance doxorubicin-mediated inhibition was investigated in human A549 lung cancer in vivo and in vitro.	Doxorubicin	86-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-55
26600514-7	2015	The results reported in the present study demonstrate for the first time that the specific COX-2 inhibitor meloxicam can increase the intracellular accumulation of doxorubicin and enhance doxorubicin-induced cytotoxicity in A549 cancer cells by reducing the expression of MRP1 and MRP4.	Meloxicam	107-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-96
26600514-7	2015	The results reported in the present study demonstrate for the first time that the specific COX-2 inhibitor meloxicam can increase the intracellular accumulation of doxorubicin and enhance doxorubicin-induced cytotoxicity in A549 cancer cells by reducing the expression of MRP1 and MRP4.	Doxorubicin	164-175	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-96
26600514-7	2015	The results reported in the present study demonstrate for the first time that the specific COX-2 inhibitor meloxicam can increase the intracellular accumulation of doxorubicin and enhance doxorubicin-induced cytotoxicity in A549 cancer cells by reducing the expression of MRP1 and MRP4.	Doxorubicin	188-199	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-96
26509841-1	2015	Subcomponent self-assembly of two isomeric bis(3-aminophenyl)pyrenes, 2-formylpyridine and the metal ions Fe(II), Co(II), and Zn(II) led to the formation of two previously unidentified structure types: a C2-symmetric M(II)4L6 assembly with meridionally coordinated metal centers, and a C3-symmetric self-included M(II)4L6 assembly with facially coordinated metal centers.	Metals	95-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-119
26509841-1	2015	Subcomponent self-assembly of two isomeric bis(3-aminophenyl)pyrenes, 2-formylpyridine and the metal ions Fe(II), Co(II), and Zn(II) led to the formation of two previously unidentified structure types: a C2-symmetric M(II)4L6 assembly with meridionally coordinated metal centers, and a C3-symmetric self-included M(II)4L6 assembly with facially coordinated metal centers.	Zinc	126-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-119
26509841-1	2015	Subcomponent self-assembly of two isomeric bis(3-aminophenyl)pyrenes, 2-formylpyridine and the metal ions Fe(II), Co(II), and Zn(II) led to the formation of two previously unidentified structure types: a C2-symmetric M(II)4L6 assembly with meridionally coordinated metal centers, and a C3-symmetric self-included M(II)4L6 assembly with facially coordinated metal centers.	(ii)4l6	218-225	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-119
26509841-1	2015	Subcomponent self-assembly of two isomeric bis(3-aminophenyl)pyrenes, 2-formylpyridine and the metal ions Fe(II), Co(II), and Zn(II) led to the formation of two previously unidentified structure types: a C2-symmetric M(II)4L6 assembly with meridionally coordinated metal centers, and a C3-symmetric self-included M(II)4L6 assembly with facially coordinated metal centers.	Metals	265-270	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-119
26509841-1	2015	Subcomponent self-assembly of two isomeric bis(3-aminophenyl)pyrenes, 2-formylpyridine and the metal ions Fe(II), Co(II), and Zn(II) led to the formation of two previously unidentified structure types: a C2-symmetric M(II)4L6 assembly with meridionally coordinated metal centers, and a C3-symmetric self-included M(II)4L6 assembly with facially coordinated metal centers.	(ii)4l6	314-321	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-119
26509841-1	2015	Subcomponent self-assembly of two isomeric bis(3-aminophenyl)pyrenes, 2-formylpyridine and the metal ions Fe(II), Co(II), and Zn(II) led to the formation of two previously unidentified structure types: a C2-symmetric M(II)4L6 assembly with meridionally coordinated metal centers, and a C3-symmetric self-included M(II)4L6 assembly with facially coordinated metal centers.	Metals	265-270	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-119
26472707-5	2015	Results indicates that pretreatment with Cucurbitacins significantly reduced the pro-inflammatory cytokine (TNF-alpha, IL-1beta and IL-6) and attenuated iNOS and COX-2 expression in TLR 2/4 agonists-stimulated microglia.	Cucurbitacins	41-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	162-167
26885023-8	2015	All volunteers received the COX-2 inhibitor celecoxib (200 mg orally twice daily) for 5 days.	Celecoxib	44-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
26509213-4	2015	In situ spectroelectrochemical measurements provided insights into the cobalt oxidation state during the course of reaction and showed that the majority of catalytic centers in this MOF are redox-accessible where Co(II) is reduced to Co(I) during catalysis.	Cobalt	71-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	213-219
26406288-5	2015	All four cages have been structurally characterised: in the Ru(ii)/Cd(ii) cage (reported in a recent communication) the Ru(ii) and Cd(ii) ions are crystallographically distinct; in the other three cages [Ru(ii)/Co(ii), Os(ii)/Cd(ii) and Os(ii)/Co(ii), reported here] the ions are disordered around the periphery such that every metal site refines as a 50 : 50 mixture of the two metal atom types.	Metals	328-333	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-72
26406288-5	2015	All four cages have been structurally characterised: in the Ru(ii)/Cd(ii) cage (reported in a recent communication) the Ru(ii) and Cd(ii) ions are crystallographically distinct; in the other three cages [Ru(ii)/Co(ii), Os(ii)/Cd(ii) and Os(ii)/Co(ii), reported here] the ions are disordered around the periphery such that every metal site refines as a 50 : 50 mixture of the two metal atom types.	Metals	328-333	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-72
26406288-5	2015	All four cages have been structurally characterised: in the Ru(ii)/Cd(ii) cage (reported in a recent communication) the Ru(ii) and Cd(ii) ions are crystallographically distinct; in the other three cages [Ru(ii)/Co(ii), Os(ii)/Cd(ii) and Os(ii)/Co(ii), reported here] the ions are disordered around the periphery such that every metal site refines as a 50 : 50 mixture of the two metal atom types.	Metals	328-333	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-72
26406288-5	2015	All four cages have been structurally characterised: in the Ru(ii)/Cd(ii) cage (reported in a recent communication) the Ru(ii) and Cd(ii) ions are crystallographically distinct; in the other three cages [Ru(ii)/Co(ii), Os(ii)/Cd(ii) and Os(ii)/Co(ii), reported here] the ions are disordered around the periphery such that every metal site refines as a 50 : 50 mixture of the two metal atom types.	Metals	328-333	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-72
26406288-5	2015	All four cages have been structurally characterised: in the Ru(ii)/Cd(ii) cage (reported in a recent communication) the Ru(ii) and Cd(ii) ions are crystallographically distinct; in the other three cages [Ru(ii)/Co(ii), Os(ii)/Cd(ii) and Os(ii)/Co(ii), reported here] the ions are disordered around the periphery such that every metal site refines as a 50 : 50 mixture of the two metal atom types.	Metals	328-333	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-72
26406288-5	2015	All four cages have been structurally characterised: in the Ru(ii)/Cd(ii) cage (reported in a recent communication) the Ru(ii) and Cd(ii) ions are crystallographically distinct; in the other three cages [Ru(ii)/Co(ii), Os(ii)/Cd(ii) and Os(ii)/Co(ii), reported here] the ions are disordered around the periphery such that every metal site refines as a 50 : 50 mixture of the two metal atom types.	Metals	328-333	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-72
26406288-5	2015	All four cages have been structurally characterised: in the Ru(ii)/Cd(ii) cage (reported in a recent communication) the Ru(ii) and Cd(ii) ions are crystallographically distinct; in the other three cages [Ru(ii)/Co(ii), Os(ii)/Cd(ii) and Os(ii)/Co(ii), reported here] the ions are disordered around the periphery such that every metal site refines as a 50 : 50 mixture of the two metal atom types.	Metals	328-333	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-72
26406288-5	2015	All four cages have been structurally characterised: in the Ru(ii)/Cd(ii) cage (reported in a recent communication) the Ru(ii) and Cd(ii) ions are crystallographically distinct; in the other three cages [Ru(ii)/Co(ii), Os(ii)/Cd(ii) and Os(ii)/Co(ii), reported here] the ions are disordered around the periphery such that every metal site refines as a 50 : 50 mixture of the two metal atom types.	Metals	379-384	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-72
26406288-5	2015	All four cages have been structurally characterised: in the Ru(ii)/Cd(ii) cage (reported in a recent communication) the Ru(ii) and Cd(ii) ions are crystallographically distinct; in the other three cages [Ru(ii)/Co(ii), Os(ii)/Cd(ii) and Os(ii)/Co(ii), reported here] the ions are disordered around the periphery such that every metal site refines as a 50 : 50 mixture of the two metal atom types.	Metals	379-384	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-72
26406288-5	2015	All four cages have been structurally characterised: in the Ru(ii)/Cd(ii) cage (reported in a recent communication) the Ru(ii) and Cd(ii) ions are crystallographically distinct; in the other three cages [Ru(ii)/Co(ii), Os(ii)/Cd(ii) and Os(ii)/Co(ii), reported here] the ions are disordered around the periphery such that every metal site refines as a 50 : 50 mixture of the two metal atom types.	Metals	379-384	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-72
26406288-5	2015	All four cages have been structurally characterised: in the Ru(ii)/Cd(ii) cage (reported in a recent communication) the Ru(ii) and Cd(ii) ions are crystallographically distinct; in the other three cages [Ru(ii)/Co(ii), Os(ii)/Cd(ii) and Os(ii)/Co(ii), reported here] the ions are disordered around the periphery such that every metal site refines as a 50 : 50 mixture of the two metal atom types.	Metals	379-384	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-72
26406288-5	2015	All four cages have been structurally characterised: in the Ru(ii)/Cd(ii) cage (reported in a recent communication) the Ru(ii) and Cd(ii) ions are crystallographically distinct; in the other three cages [Ru(ii)/Co(ii), Os(ii)/Cd(ii) and Os(ii)/Co(ii), reported here] the ions are disordered around the periphery such that every metal site refines as a 50 : 50 mixture of the two metal atom types.	Metals	379-384	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-72
26406288-5	2015	All four cages have been structurally characterised: in the Ru(ii)/Cd(ii) cage (reported in a recent communication) the Ru(ii) and Cd(ii) ions are crystallographically distinct; in the other three cages [Ru(ii)/Co(ii), Os(ii)/Cd(ii) and Os(ii)/Co(ii), reported here] the ions are disordered around the periphery such that every metal site refines as a 50 : 50 mixture of the two metal atom types.	Metals	379-384	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-72
26406288-5	2015	All four cages have been structurally characterised: in the Ru(ii)/Cd(ii) cage (reported in a recent communication) the Ru(ii) and Cd(ii) ions are crystallographically distinct; in the other three cages [Ru(ii)/Co(ii), Os(ii)/Cd(ii) and Os(ii)/Co(ii), reported here] the ions are disordered around the periphery such that every metal site refines as a 50 : 50 mixture of the two metal atom types.	Metals	379-384	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-72
26406288-6	2015	The incorporation of Os(ii) units into the cages results in both redox activity [a reversible Os(ii)/Os(iii) couple for all four metal ions simultaneously, at a modest potential] and luminescence [the Os(ii) units have luminescent (3)MLCT excited states which will be good photo-electron donors] being incorporated into the cage superstructure.	Metals	129-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-26
26406288-6	2015	The incorporation of Os(ii) units into the cages results in both redox activity [a reversible Os(ii)/Os(iii) couple for all four metal ions simultaneously, at a modest potential] and luminescence [the Os(ii) units have luminescent (3)MLCT excited states which will be good photo-electron donors] being incorporated into the cage superstructure.	Metals	129-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-99
26406288-6	2015	The incorporation of Os(ii) units into the cages results in both redox activity [a reversible Os(ii)/Os(iii) couple for all four metal ions simultaneously, at a modest potential] and luminescence [the Os(ii) units have luminescent (3)MLCT excited states which will be good photo-electron donors] being incorporated into the cage superstructure.	Metals	129-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-99
27293584-4	2015	Herein we describe the stepwise optimisation of reaction parameters (pH, reagent concentrations and reaction time) for the room temperature, water-based synthesis of several members of the CPO-27/MOF-74-M series of MOFs, including ones made from Mg(II), Ni(II), Co(II) and Zn(II) ions.	cpo	189-192	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	262-268
26350254-7	2015	These results were supported by experiments in the human colonic epithelial cell line Caco-2, where ALA supplementation was shown to be effective in inhibiting inflammation induced by IL-1beta by down-regulating mRNA levels of pro-inflammatory genes including IL-8, COX2 and inducible nitric oxide synthase.	alpha-Linolenic Acid	100-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	266-270
26545734-5	2015	RESULTS: For COX-2 inhibitors, celecoxib dispensing halved after rofecoxib withdrawal, but meloxicam dispensing increased by 60 %.	Celecoxib	31-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
26056978-2	2015	In this work benzimidazole based metal organic thin films of dichlorobis (1H-Benzimidazole) Co(II) and dichlorobis (1H-Benzimidazole) Cu(II) were deposited by chemical bath deposition method.	benzimidazole	13-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-98
26056978-2	2015	In this work benzimidazole based metal organic thin films of dichlorobis (1H-Benzimidazole) Co(II) and dichlorobis (1H-Benzimidazole) Cu(II) were deposited by chemical bath deposition method.	Metals	33-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-98
26056978-2	2015	In this work benzimidazole based metal organic thin films of dichlorobis (1H-Benzimidazole) Co(II) and dichlorobis (1H-Benzimidazole) Cu(II) were deposited by chemical bath deposition method.	dichlorobis (1h-benzimidazole)	61-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-98
26190312-9	2015	COX-2 expression was higher after 72 hr of treatment with PBDE-99.	2,2',4,4',5-brominated diphenyl ether	58-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
26456774-8	2015	DHT inhibited resveratrol-induced nuclear complex of p53-COX-2 formation which is required p53-dependent apoptosis.	Dihydrotestosterone	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-62
26456774-8	2015	DHT inhibited resveratrol-induced nuclear complex of p53-COX-2 formation which is required p53-dependent apoptosis.	Resveratrol	14-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-62
26456774-9	2015	ChIP studies of COX-2/p53 binding to DNA and expression of p53-responsive genes indicated that DHT inhibited resveratrol-induced p53-directed transcriptional activity.	Dihydrotestosterone	95-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-21
26456774-9	2015	ChIP studies of COX-2/p53 binding to DNA and expression of p53-responsive genes indicated that DHT inhibited resveratrol-induced p53-directed transcriptional activity.	Resveratrol	109-120	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-21
26456774-10	2015	In addition, DHT did inhibit resveratrol-induced COX-2/p53-dependent gene expression.	Dihydrotestosterone	13-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-54
26456774-10	2015	In addition, DHT did inhibit resveratrol-induced COX-2/p53-dependent gene expression.	Resveratrol	29-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-54
26456774-11	2015	These results suggest that DHT inhibits p53-dependent apoptosis in breast cancer cells by interfering with nuclear COX-2 accumulation which is essential for stimulation of apoptotic pathways.	Dihydrotestosterone	27-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-120
26190312-11	2015	CONCLUSIONS: Congener-dependent OS response, p38 MAPK activation, senescence, and COX-2 expression were seen in human amnion cells by PBDEs.	Halogenated Diphenyl Ethers	134-139	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
25904239-4	2015	While compounds 13e, 13h and 13i showed moderate COX-2 selectivity in vitro and good anti-inflammatory activity in vivo, compound 13i showed the highest anti-inflammatory activity that is very close in potency to the reference drug (celecoxib) with better gastric profile than celecoxib.	13h	21-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-54
25904239-4	2015	While compounds 13e, 13h and 13i showed moderate COX-2 selectivity in vitro and good anti-inflammatory activity in vivo, compound 13i showed the highest anti-inflammatory activity that is very close in potency to the reference drug (celecoxib) with better gastric profile than celecoxib.	13I	29-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-54
25847254-3	2015	We found that 10-MDP caused the release of inflammatory cytokines including NO, PGE2, iNOS, COX-2, TNF-alpha, IL-1beta, IL-6 and IL-8 in a concentration-dependent manner.	methacryloyloxydecyl dihydrogen phosphate	14-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-97
26359950-0	2015	Mevastatin ameliorates sphingosine 1-phosphate-induced COX-2/PGE2-dependent cell migration via FoxO1 and CREB phosphorylation and translocation.	mevastatin	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-60
26116446-6	2015	Until now, leaching of Co(II) from LiCoO2 particles, and removal of metal ions i.e. Co(III/II), Cr(VI), Cu(II), Hg(II), Ag(I), Se(IV), and Cd(II) from aqueous solutions has been demonstrated.	licoo2	35-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-29
26556331-1	2015	In this study, immobilized COX-2 was successfully constructed through glutaraldehyde-mediated covalent coupling on functional silica gel microspheres.	Glutaral	70-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-32
26556331-1	2015	In this study, immobilized COX-2 was successfully constructed through glutaraldehyde-mediated covalent coupling on functional silica gel microspheres.	Silica Gel	126-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-32
26359950-0	2015	Mevastatin ameliorates sphingosine 1-phosphate-induced COX-2/PGE2-dependent cell migration via FoxO1 and CREB phosphorylation and translocation.	sphingosine 1-phosphate	23-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-60
26359950-0	2015	Mevastatin ameliorates sphingosine 1-phosphate-induced COX-2/PGE2-dependent cell migration via FoxO1 and CREB phosphorylation and translocation.	Dinoprostone	61-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-60
26377664-2	2015	Although epidemiological, clinical and preclinical studies have shown that the inhibition of PGE2 synthesis through the use of either non-steroidal anti-inflammatory drugs (NSAIDs) or specific COX-2 inhibitors (COXibs) has the potential to prevent and treat malignant disease, toxicities due to inhibition of COX-2 have limited their use.	Dinoprostone	93-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	309-314
26359950-1	2015	BACKGROUND AND PURPOSE: Sphingosine 1-phosphate (S1P), an important inflammatory mediator, has been shown to regulate COX-2 production and promote various cellular responses such as cell migration.	sphingosine 1-phosphate	24-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-123
26359950-1	2015	BACKGROUND AND PURPOSE: Sphingosine 1-phosphate (S1P), an important inflammatory mediator, has been shown to regulate COX-2 production and promote various cellular responses such as cell migration.	sphingosine 1-phosphate	49-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-123
26359950-3	2015	However, the mechanisms underlying S1P-evoked COX-2-dependent cell migration, which is modulated by mevastatin in human tracheal smooth muscle cells (HTSMCs) remain unclear.	mevastatin	100-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
26592832-1	2015	OBJECTIVE: The goal of this study was to determine the effect of celecoxib, a selective COX-2 inhibitor, on the growth inhibition of osteosarcoma and its potential anticancer mechanisms.	Celecoxib	65-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-93
26438445-0	2015	Theoretical and experimental studies on three new coordination complexes of Co(II), Ni(II), and Cu(II) with 2,4-dichloro-6-{(E)-[(5-chloro-2 sulfanylphenyl)imino]methyl}phenol Schiff base ligand.	cu(ii)	96-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-82
26586936-7	2015	As4S4 inhibited COX2 and cyclin D1 expression.	as4s4	0-5	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-20
26359950-10	2015	Finally, we showed that pretreatment with mevastatin markedly reduced S1P-induced cell migration and COX-2/PGE2 production via a PPARgamma-dependent signalling pathway.	mevastatin	42-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-106
26359950-11	2015	CONCLUSIONS AND IMPLICATIONS: Mevastatin attenuates the S1P-induced increased expression of COX-2 and cell migration via the regulation of FoxO1 and CREB phosphorylation and translocation by PPARgamma in HTSMCs.	mevastatin	30-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-97
26377664-2	2015	Although epidemiological, clinical and preclinical studies have shown that the inhibition of PGE2 synthesis through the use of either non-steroidal anti-inflammatory drugs (NSAIDs) or specific COX-2 inhibitors (COXibs) has the potential to prevent and treat malignant disease, toxicities due to inhibition of COX-2 have limited their use.	Dinoprostone	93-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	193-198
25894361-7	2015	Based on the docking studies, scaffold 2-thiazolylimino-5-benzylidene-thiazolidin-4-one is observed to exhibit affinity against diverse targets, particularly, towards COX-2, acetylcholinesterase, aldose reductase, and thyroid hormone receptor alpha.	2-thiazolylimino-5-benzylidene-thiazolidin-4-one	39-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	167-172
26352871-3	2015	Induction of COX-2 and membrane-associated PGE synthase 1 (mPGES-1), which are overexpressed in numerous cancer types, cooperatively enhance PGE2 expression, which contributes to carcinogenesis and cancer progression.	Dinoprostone	141-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
25956433-2	2015	NSAIDs profoundly modify prostaglandin homeostasis through inhibition of the enzyme, cyclooxygenase (COX), especially COX-2.	Prostaglandins	25-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-123
26586936-8	2015	When As4S4 was combined with chemotherapy drug cisplatin or COX2 inhibitor celecoxib, its inhibition of COX2, BCL2, and p38 expression was enhanced.	as4s4	5-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-64
26586936-8	2015	When As4S4 was combined with chemotherapy drug cisplatin or COX2 inhibitor celecoxib, its inhibition of COX2, BCL2, and p38 expression was enhanced.	as4s4	5-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-108
26586936-8	2015	When As4S4 was combined with chemotherapy drug cisplatin or COX2 inhibitor celecoxib, its inhibition of COX2, BCL2, and p38 expression was enhanced.	Cisplatin	47-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-108
26586936-8	2015	When As4S4 was combined with chemotherapy drug cisplatin or COX2 inhibitor celecoxib, its inhibition of COX2, BCL2, and p38 expression was enhanced.	Celecoxib	75-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-64
26586936-8	2015	When As4S4 was combined with chemotherapy drug cisplatin or COX2 inhibitor celecoxib, its inhibition of COX2, BCL2, and p38 expression was enhanced.	Celecoxib	75-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-108
26399396-1	2015	Adducts of Co(II) diketonates with cyclic redox-active tetraone ligands.	cyclic redox	35-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-16
26604686-6	2015	Increased level of PGs in premalignant and/or malignant cutaneous tumors is also favored by upregulation of COX-2 and downregulation of the tumor suppressor gene 15-hydroxy-prostaglandin dehydrogenase.	Prostaglandins	19-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-113
26399396-1	2015	Adducts of Co(II) diketonates with cyclic redox-active tetraone ligands.	tetraone	55-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-16
26391615-0	2015	Three tetracoordinate Co(II) complexes [Co(biq)X2] (X = Cl, Br, I) with easy-plane magnetic anisotropy as field-induced single-molecule magnets.	co(biq)x2	40-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-28
26434364-4	2015	Key elements in these total syntheses include: (1) FeCl3-catalyzed cationic cascade cyclization to construct podocarpane-type skeleton; (2) Mn(III)/Co(II)-catalyzed radical hydroxylation of alkene with high regio-, diastereo-, and chemoselectivities; (3) and a ketal-deprotection/lactone-opening/deprotonation/lactonization cascade.	ferric chloride	51-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	148-153
26391615-2	2015	In all three complexes the Co(ii) atom is tetrahedrally coordinated by one biq ligand bonded in a chelate manner and two halogenido ligands.	Bis-Q	75-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-33
26393338-1	2015	This work presents synthesis and characterization of trinuclear {Co(2+)-Co(3+)-Co(2+)} and {Co(2+)-Fe(3+)-Co(2+)} complexes with accessible peripheral Co(ii) ions.	Cobalt(2+)	65-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-157
26393338-1	2015	This work presents synthesis and characterization of trinuclear {Co(2+)-Co(3+)-Co(2+)} and {Co(2+)-Fe(3+)-Co(2+)} complexes with accessible peripheral Co(ii) ions.	cobalt adenosine diphosphate complex	72-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-157
26434364-4	2015	Key elements in these total syntheses include: (1) FeCl3-catalyzed cationic cascade cyclization to construct podocarpane-type skeleton; (2) Mn(III)/Co(II)-catalyzed radical hydroxylation of alkene with high regio-, diastereo-, and chemoselectivities; (3) and a ketal-deprotection/lactone-opening/deprotonation/lactonization cascade.	podocarpane	109-120	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	148-153
26393338-1	2015	This work presents synthesis and characterization of trinuclear {Co(2+)-Co(3+)-Co(2+)} and {Co(2+)-Fe(3+)-Co(2+)} complexes with accessible peripheral Co(ii) ions.	Cobalt(2+)	79-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-157
26393338-1	2015	This work presents synthesis and characterization of trinuclear {Co(2+)-Co(3+)-Co(2+)} and {Co(2+)-Fe(3+)-Co(2+)} complexes with accessible peripheral Co(ii) ions.	Cobalt(2+)	79-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-157
26434364-4	2015	Key elements in these total syntheses include: (1) FeCl3-catalyzed cationic cascade cyclization to construct podocarpane-type skeleton; (2) Mn(III)/Co(II)-catalyzed radical hydroxylation of alkene with high regio-, diastereo-, and chemoselectivities; (3) and a ketal-deprotection/lactone-opening/deprotonation/lactonization cascade.	Alkenes	190-196	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	148-153
26393338-1	2015	This work presents synthesis and characterization of trinuclear {Co(2+)-Co(3+)-Co(2+)} and {Co(2+)-Fe(3+)-Co(2+)} complexes with accessible peripheral Co(ii) ions.	ferric sulfate	99-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-157
26434364-4	2015	Key elements in these total syntheses include: (1) FeCl3-catalyzed cationic cascade cyclization to construct podocarpane-type skeleton; (2) Mn(III)/Co(II)-catalyzed radical hydroxylation of alkene with high regio-, diastereo-, and chemoselectivities; (3) and a ketal-deprotection/lactone-opening/deprotonation/lactonization cascade.	Lactones	280-287	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	148-153
26393338-1	2015	This work presents synthesis and characterization of trinuclear {Co(2+)-Co(3+)-Co(2+)} and {Co(2+)-Fe(3+)-Co(2+)} complexes with accessible peripheral Co(ii) ions.	Cobalt(2+)	79-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-157
26393338-3	2015	The mechanistic investigations suggest the involvement of a Co(ii)-Co(i) cycle in the catalysis.	NAD	67-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-66
26493885-2	2015	The investigated systems contain the benzotriazinyl radical 1 coordinated to a divalent metal cation, Mn(II) , Fe(II) , Co(II) , or Ni(II) , with 1,1,1,5,5,5-hexafluoroacetylacetonato (hfac) as the auxiliary ligand of choice.	benzotriazinyl radical	37-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-126
26323791-1	2015	A one-photon two-electron process was made possible in photocatalytic H2 evolution from ascorbic acid with a cobalt(II) chlorin complex [Co(II)(Ch)] via electron transfer from ascorbate to the excited state of [Ru(bpy)3](2+) followed by electron transfer from [Ru(bpy)3](+) to Co(II)(Ch) with proton to give the hydride complex, which reacts with proton to produce H2.	Hydrogen	70-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-143
26323791-1	2015	A one-photon two-electron process was made possible in photocatalytic H2 evolution from ascorbic acid with a cobalt(II) chlorin complex [Co(II)(Ch)] via electron transfer from ascorbate to the excited state of [Ru(bpy)3](2+) followed by electron transfer from [Ru(bpy)3](+) to Co(II)(Ch) with proton to give the hydride complex, which reacts with proton to produce H2.	Hydrogen	70-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	277-283
26323791-1	2015	A one-photon two-electron process was made possible in photocatalytic H2 evolution from ascorbic acid with a cobalt(II) chlorin complex [Co(II)(Ch)] via electron transfer from ascorbate to the excited state of [Ru(bpy)3](2+) followed by electron transfer from [Ru(bpy)3](+) to Co(II)(Ch) with proton to give the hydride complex, which reacts with proton to produce H2.	Ascorbic Acid	88-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-143
26323791-1	2015	A one-photon two-electron process was made possible in photocatalytic H2 evolution from ascorbic acid with a cobalt(II) chlorin complex [Co(II)(Ch)] via electron transfer from ascorbate to the excited state of [Ru(bpy)3](2+) followed by electron transfer from [Ru(bpy)3](+) to Co(II)(Ch) with proton to give the hydride complex, which reacts with proton to produce H2.	Ascorbic Acid	88-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	277-283
26323791-1	2015	A one-photon two-electron process was made possible in photocatalytic H2 evolution from ascorbic acid with a cobalt(II) chlorin complex [Co(II)(Ch)] via electron transfer from ascorbate to the excited state of [Ru(bpy)3](2+) followed by electron transfer from [Ru(bpy)3](+) to Co(II)(Ch) with proton to give the hydride complex, which reacts with proton to produce H2.	cobalt(ii) chlorin	109-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-143
26323791-1	2015	A one-photon two-electron process was made possible in photocatalytic H2 evolution from ascorbic acid with a cobalt(II) chlorin complex [Co(II)(Ch)] via electron transfer from ascorbate to the excited state of [Ru(bpy)3](2+) followed by electron transfer from [Ru(bpy)3](+) to Co(II)(Ch) with proton to give the hydride complex, which reacts with proton to produce H2.	cobalt(ii) chlorin	109-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	277-283
26323791-1	2015	A one-photon two-electron process was made possible in photocatalytic H2 evolution from ascorbic acid with a cobalt(II) chlorin complex [Co(II)(Ch)] via electron transfer from ascorbate to the excited state of [Ru(bpy)3](2+) followed by electron transfer from [Ru(bpy)3](+) to Co(II)(Ch) with proton to give the hydride complex, which reacts with proton to produce H2.	Ascorbic Acid	176-185	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-143
26323791-1	2015	A one-photon two-electron process was made possible in photocatalytic H2 evolution from ascorbic acid with a cobalt(II) chlorin complex [Co(II)(Ch)] via electron transfer from ascorbate to the excited state of [Ru(bpy)3](2+) followed by electron transfer from [Ru(bpy)3](+) to Co(II)(Ch) with proton to give the hydride complex, which reacts with proton to produce H2.	Ascorbic Acid	176-185	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	277-283
26323791-1	2015	A one-photon two-electron process was made possible in photocatalytic H2 evolution from ascorbic acid with a cobalt(II) chlorin complex [Co(II)(Ch)] via electron transfer from ascorbate to the excited state of [Ru(bpy)3](2+) followed by electron transfer from [Ru(bpy)3](+) to Co(II)(Ch) with proton to give the hydride complex, which reacts with proton to produce H2.	[ru(bpy)3](2+)	210-224	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-143
26323791-1	2015	A one-photon two-electron process was made possible in photocatalytic H2 evolution from ascorbic acid with a cobalt(II) chlorin complex [Co(II)(Ch)] via electron transfer from ascorbate to the excited state of [Ru(bpy)3](2+) followed by electron transfer from [Ru(bpy)3](+) to Co(II)(Ch) with proton to give the hydride complex, which reacts with proton to produce H2.	[ru(bpy)3](2+)	210-224	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	277-283
26323791-1	2015	A one-photon two-electron process was made possible in photocatalytic H2 evolution from ascorbic acid with a cobalt(II) chlorin complex [Co(II)(Ch)] via electron transfer from ascorbate to the excited state of [Ru(bpy)3](2+) followed by electron transfer from [Ru(bpy)3](+) to Co(II)(Ch) with proton to give the hydride complex, which reacts with proton to produce H2.	ru(bpy)3	260-273	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-143
26323791-1	2015	A one-photon two-electron process was made possible in photocatalytic H2 evolution from ascorbic acid with a cobalt(II) chlorin complex [Co(II)(Ch)] via electron transfer from ascorbate to the excited state of [Ru(bpy)3](2+) followed by electron transfer from [Ru(bpy)3](+) to Co(II)(Ch) with proton to give the hydride complex, which reacts with proton to produce H2.	ru(bpy)3	260-273	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	277-283
26323791-1	2015	A one-photon two-electron process was made possible in photocatalytic H2 evolution from ascorbic acid with a cobalt(II) chlorin complex [Co(II)(Ch)] via electron transfer from ascorbate to the excited state of [Ru(bpy)3](2+) followed by electron transfer from [Ru(bpy)3](+) to Co(II)(Ch) with proton to give the hydride complex, which reacts with proton to produce H2.	Creatinine	312-319	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-143
26323791-1	2015	A one-photon two-electron process was made possible in photocatalytic H2 evolution from ascorbic acid with a cobalt(II) chlorin complex [Co(II)(Ch)] via electron transfer from ascorbate to the excited state of [Ru(bpy)3](2+) followed by electron transfer from [Ru(bpy)3](+) to Co(II)(Ch) with proton to give the hydride complex, which reacts with proton to produce H2.	Creatinine	312-319	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	277-283
26323791-1	2015	A one-photon two-electron process was made possible in photocatalytic H2 evolution from ascorbic acid with a cobalt(II) chlorin complex [Co(II)(Ch)] via electron transfer from ascorbate to the excited state of [Ru(bpy)3](2+) followed by electron transfer from [Ru(bpy)3](+) to Co(II)(Ch) with proton to give the hydride complex, which reacts with proton to produce H2.	Hydrogen	365-367	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-143
26323791-1	2015	A one-photon two-electron process was made possible in photocatalytic H2 evolution from ascorbic acid with a cobalt(II) chlorin complex [Co(II)(Ch)] via electron transfer from ascorbate to the excited state of [Ru(bpy)3](2+) followed by electron transfer from [Ru(bpy)3](+) to Co(II)(Ch) with proton to give the hydride complex, which reacts with proton to produce H2.	Hydrogen	365-367	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	277-283
26323791-2	2015	[Co(III)(Ch)](+) was reduced by ascorbate to reproduce Co(II)(Ch).	co(iii)	1-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-61
26323791-2	2015	[Co(III)(Ch)](+) was reduced by ascorbate to reproduce Co(II)(Ch).	Ascorbic Acid	32-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-61
26324662-1	2015	A new type of homochiral metal-organic nanotubular structures based on metal phosphonates are reported, namely, (R)- or (S)-[M(pemp)(H2O)2][M = Co(II) (1), Ni(II) (2)] [pemp(2-) = (R)- or (S)-(1-phenylethylamino)methylphosphonate].	Metals	25-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	144-150
26324662-1	2015	A new type of homochiral metal-organic nanotubular structures based on metal phosphonates are reported, namely, (R)- or (S)-[M(pemp)(H2O)2][M = Co(II) (1), Ni(II) (2)] [pemp(2-) = (R)- or (S)-(1-phenylethylamino)methylphosphonate].	(R)-(2,3-Dimethoxyphenyl)-4-piperidinemethanol	112-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	144-150
26220687-3	2015	In the present study, we hypothesized that ethanol would enhance the function of an environmental carcinogen such as arsenic through increase in COX-2 expression.	Ethanol	43-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-150
26594532-2	2015	The Co(II) ion has a slightly distorted octahedral coordination environment which is defined by two N atoms occupying the apical position, while the equatorial plane is furnished by two hy-droxy O atoms and two carboxyl-ate O atoms.	Nitrogen	100-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
26143270-5	2015	In the first step, apart from the known oxidation of bromide to free bromine and of free bromine to bromate by sulfate radicals (SO4(-)), Co(III) produced from the oxidation of Co(II) by PMS and SO4(-) also oxidizes bromide to free bromine.	peroxymonosulfate	187-190	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	138-143
26143270-5	2015	In the first step, apart from the known oxidation of bromide to free bromine and of free bromine to bromate by sulfate radicals (SO4(-)), Co(III) produced from the oxidation of Co(II) by PMS and SO4(-) also oxidizes bromide to free bromine.	sulfuric acid	195-198	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	138-143
26143270-5	2015	In the first step, apart from the known oxidation of bromide to free bromine and of free bromine to bromate by sulfate radicals (SO4(-)), Co(III) produced from the oxidation of Co(II) by PMS and SO4(-) also oxidizes bromide to free bromine.	Bromides	216-223	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	138-143
26220687-3	2015	In the present study, we hypothesized that ethanol would enhance the function of an environmental carcinogen such as arsenic through increase in COX-2 expression.	Arsenic	117-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-150
26143270-7	2015	In the presence of methanol, free bromine formation increased with increasing Co(II) dosage but no bromate was detected, indicating that Co(III) oxidized bromide to form free bromine but not bromate.	Methanol	19-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-83
26143270-7	2015	In the presence of methanol, free bromine formation increased with increasing Co(II) dosage but no bromate was detected, indicating that Co(III) oxidized bromide to form free bromine but not bromate.	Bromine	34-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-83
26220687-4	2015	Our in vitro results show that ethanol enhanced arsenic-induced COX-2 expression.	Ethanol	31-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-69
26143270-7	2015	In the presence of methanol, free bromine formation increased with increasing Co(II) dosage but no bromate was detected, indicating that Co(III) oxidized bromide to form free bromine but not bromate.	Bromides	154-161	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-83
26220687-4	2015	Our in vitro results show that ethanol enhanced arsenic-induced COX-2 expression.	Arsenic	48-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-69
26220687-5	2015	We also show that the increased COX-2 expression associates with intracellular ROS generation, up-regulated AKT signaling, with activation of both NFAT and NF-kappaB pathways.	ros	79-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-37
26220687-6	2015	We demonstrate that antioxidant enzymes have an inhibitory effect on arsenic/ethanol-induced COX-2 expression, indicating that the responsive signaling pathways from co-exposure to arsenic and ethanol relate to ROS generation.	Arsenic	69-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-98
26220687-6	2015	We demonstrate that antioxidant enzymes have an inhibitory effect on arsenic/ethanol-induced COX-2 expression, indicating that the responsive signaling pathways from co-exposure to arsenic and ethanol relate to ROS generation.	Ethanol	77-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-98
26220687-6	2015	We demonstrate that antioxidant enzymes have an inhibitory effect on arsenic/ethanol-induced COX-2 expression, indicating that the responsive signaling pathways from co-exposure to arsenic and ethanol relate to ROS generation.	Arsenic	181-188	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-98
26220687-6	2015	We demonstrate that antioxidant enzymes have an inhibitory effect on arsenic/ethanol-induced COX-2 expression, indicating that the responsive signaling pathways from co-exposure to arsenic and ethanol relate to ROS generation.	Ethanol	193-200	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-98
26220687-6	2015	We demonstrate that antioxidant enzymes have an inhibitory effect on arsenic/ethanol-induced COX-2 expression, indicating that the responsive signaling pathways from co-exposure to arsenic and ethanol relate to ROS generation.	ros	211-214	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-98
26220687-8	2015	We conclude that ethanol enhances arsenic-induced COX-2 expression in colorectal cancer cells via both the NFAT and NF-kappaB pathways.	Ethanol	17-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-55
26220687-8	2015	We conclude that ethanol enhances arsenic-induced COX-2 expression in colorectal cancer cells via both the NFAT and NF-kappaB pathways.	Arsenic	34-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-55
26440517-0	2015	Food Polyphenols Fail to Cause a Biologically Relevant Reduction of COX-2 Activity.	Polyphenols	5-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-73
26314616-10	2015	In parallel, the solid-state transformation of CoOOH(s) and Co(II)(ad) to form Co3O4(s) occurs.	co3o4	79-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-66
26359357-3	2015	Ectopic over-expression of COX-2 in TAMs enhanced breast cancer cell survival both in vitro and in vivo.	tams	36-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-32
26359357-4	2015	COX-2 in TAMs was determined to be essential for the induction and maintenance of M2-phenotype macrophage polarity.	tams	9-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
26359357-7	2015	Inhibiting PI3K/Akt pathway in cancer cells suppressed COX-2(+) TAMs-induced cancer cell survival.	tams	64-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-60
26438445-0	2015	Theoretical and experimental studies on three new coordination complexes of Co(II), Ni(II), and Cu(II) with 2,4-dichloro-6-{(E)-[(5-chloro-2 sulfanylphenyl)imino]methyl}phenol Schiff base ligand.	2,4-dichloro-6-{(e)-[(5-chloro-2 sulfanylphenyl)imino]methyl}phenol schiff base	108-187	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-82
26440517-4	2015	This study characterized effects of a subset of polyphenols on COX-2 expression and activity in vitro and compared the potency with known drugs.	Polyphenols	48-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-68
26438445-8	2015	Graphical abstract Three new coordination complexes of Co(II), Ni(II) and Cu(II) with 2,4-dichloro-6-{(E)-[(5-chloro-2 sulfanylphenyl)imino]methyl}phenol Schiff base ligand.	Nickel(2+)	63-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-61
26440517-6	2015	Enzyme assays and incubations of polyphenols with the cancer cell line HCA-7 and lipopolysaccharide (LPS) stimulated primary monocytes support the hypothesis that polyphenols can effect COX-2 expression and activity in vitro.	Polyphenols	163-174	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	186-191
26438445-8	2015	Graphical abstract Three new coordination complexes of Co(II), Ni(II) and Cu(II) with 2,4-dichloro-6-{(E)-[(5-chloro-2 sulfanylphenyl)imino]methyl}phenol Schiff base ligand.	cu(ii)	74-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-61
26279265-0	2015	Spontaneous symmetry breaking of Co(II) metal-organic frameworks from achiral precursors via asymmetrical crystallization.	Metals	40-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-39
26438445-8	2015	Graphical abstract Three new coordination complexes of Co(II), Ni(II) and Cu(II) with 2,4-dichloro-6-{(E)-[(5-chloro-2 sulfanylphenyl)imino]methyl}phenol Schiff base ligand.	2,4-dichloro-6-{(e)-[(5-chloro-2 sulfanylphenyl)imino]methyl}phenol schiff base	86-165	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-61
26162701-5	2015	The results showed that farrerol remarkably inhibited IL-1beta-induced NO and PGE2 production, as well as COX-2 and iNOS expression.	farrerol	24-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-111
26378471-2	2015	For Mn(II), Fe(II), and Co(II), complexes of formula Na2[M(AzaIn)4] 2L (L = tetrahydrofuran (THF), 2-MeTHF, toluene, or benzene) were isolated by treatment of the corresponding metal chloride salts with 7-azaindole in the presence of sodium hexamethyldisilazide.	na2[m(azain)4] 2l	53-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-30
26177858-7	2015	KEY RESULTS: EPA offered significant cytoprotection by increasing EPA/AA ratios in cell membranes, inhibiting ROS generation, enhancing antioxidant status and modulating nuclear translocation of redox-sensitive transcription factors (NF-kappaB p65 and Nrf-2) and expression of NF-kappaB p65, COX-2 and Nrf-2.	Eicosapentaenoic Acid	13-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	292-297
26381025-9	2015	In addition, the Melasma Activity and Severity Index score, fraction of solar elastosis, and epidermal melanin were positively associated with COX-2 expression.	Melanins	103-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	143-148
26299912-7	2015	This new well-demonstrated action of paracetamol on peripheral COX-2 of intact cells could explain recent observations making this drug a potential alternative in treating patent ductus arteriosus.	Acetaminophen	37-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-68
26275572-4	2015	Protein and gene expression levels for genes related to COX-2 and RXRalpha were evaluated in tumor samples from before and after etodolac exposure.	Etodolac	129-137	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-61
26275572-8	2015	Additionally, etodolac exposure was associated with a significant increase in COX-2 gene expression levels (fold change: 3.25 [95% CI: 1.9, 5.55]) and a trend toward increased beta-catenin expression (fold change: 2.03 [95% CI: 0.93, 4.47]).	Etodolac	14-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-83
26160915-4	2015	Complete loss of COA6 activity using gene editing in HEK293T cells resulted in a profound growth defect due to complex IV deficiency, caused by impaired biogenesis of the copper-bound mitochondrial DNA-encoded subunit COX2 and subsequent accumulation of complex IV assembly intermediates.	Copper	171-177	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	218-222
26160915-7	2015	Our data reveal that COA6 is intricately involved in the copper-dependent biogenesis of COX2.	Copper	57-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-92
26026498-3	2015	Treatment with 20 muM BDE-47 significantly increased mRNA expression of prostaglandin-endoperoxide synthase 2 (PTGS2) at 4, 12 and 24 h, and 24-h treatment significantly increased cyclooxygenase (COX)-2 cellular protein expression and prostaglandin E2 (PGE2) concentration in culture medium.	2,2',4,4'-tetrabromodiphenyl ether	22-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	180-202
26664375-1	2015	As a continuous research for discovery of new COX-2 inhibitors, chemical synthesis, in vitro biological activity and molecular docking study of a new group of 1, 4-dihydropyridine (DHP) derivatives were presented.	1,4-dihydropyridine	159-179	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
26664375-1	2015	As a continuous research for discovery of new COX-2 inhibitors, chemical synthesis, in vitro biological activity and molecular docking study of a new group of 1, 4-dihydropyridine (DHP) derivatives were presented.	dhp	181-184	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
26664375-2	2015	Novel synthesized compounds possessing a COX-2 SO2Me pharmacophore at the para position of C-4 phenyl ring, different hydrophobic groups (R1) at C-2 position and alkoxycarbonyl groups (COOR2) at C-3 position of 1, 4-dihydropyridine, displayed selective inhibitory activity against COX-2 isozyme.	so2me	47-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-46
26664375-5	2015	The study showed that the p-SO2Me-phenyl fragment of 5e inserted inside secondary COX-2 binding site (Arg(513), Phe(518), Gly(519), and His(90)).	Arginine	102-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
26664375-5	2015	The study showed that the p-SO2Me-phenyl fragment of 5e inserted inside secondary COX-2 binding site (Arg(513), Phe(518), Gly(519), and His(90)).	Phenylalanine	112-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
26664375-5	2015	The study showed that the p-SO2Me-phenyl fragment of 5e inserted inside secondary COX-2 binding site (Arg(513), Phe(518), Gly(519), and His(90)).	Glycine	122-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
26119525-2	2015	Therefore we decided to examine whether cyclooxygenases (particular COX-2) activity and expression may be changed by fluoride in THP1 macrophages and in this way may change the prostanoids biosynthesis.	Fluorides	117-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-73
26119525-2	2015	Therefore we decided to examine whether cyclooxygenases (particular COX-2) activity and expression may be changed by fluoride in THP1 macrophages and in this way may change the prostanoids biosynthesis.	Prostaglandins	177-188	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-73
26119525-5	2015	COX-2 protein up-regulation probably is mediated by ROS, produced during fluoride-induced inflammatory reactions.	ros	52-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
26119525-5	2015	COX-2 protein up-regulation probably is mediated by ROS, produced during fluoride-induced inflammatory reactions.	Fluorides	73-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
26119525-6	2015	Additional fluoride activates the transcription factor, nuclear factor (NF)-kappaB, which is involved in the up-regulation of COX-2 gene expression.	Fluorides	11-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-131
26119525-7	2015	This study indicated that even in small concentrations fluoride changes the amounts and activity of COX-1 and COX-2 enzymes taking part in the initiating and development of inflammatory process.	Fluorides	55-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-115
26347189-1	2015	A novel two-dimensional (2D) coordination polymer, [Co(ppad)2]n (1), resulted from the assembly of Co(II) ions based on a versatile ligand termed N(3)-(3-pyridoyl)-3-pyridinecarboxamidrazone.	[co(ppad)2]n (1)	51-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-105
26057147-0	2015	COX-2 induces lytic reactivation of EBV through PGE2 by modulating the EP receptor signaling pathway.	Dinoprostone	48-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
26057147-4	2015	In various tumors, PGE2 is the principle COX-2 regulated downstream product which exerts its effects on cellular processes through the EP1-4 receptors.	Dinoprostone	19-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-46
26057147-6	2015	Our data suggest a role for upregulated COX-2 on modulation of EBV latency through its downstream effector PGE2.	Dinoprostone	107-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
26347189-1	2015	A novel two-dimensional (2D) coordination polymer, [Co(ppad)2]n (1), resulted from the assembly of Co(II) ions based on a versatile ligand termed N(3)-(3-pyridoyl)-3-pyridinecarboxamidrazone.	n(3)-(3-pyridoyl)-3-pyridinecarboxamidrazone	146-190	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-105
26389864-9	2015	To determine the mechanism of the anti-inflammatory activity of 17c, a docking study was carried out on the COX-2 enzyme.	17c	64-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-113
26235941-7	2015	BK, through activation of the kinin B2 receptor, potentiated the COX-2 mediated prostaglandin release in cytokines-primed RPE cells while new protein synthesis and prostaglandin production contribute to the potentiating effect of cytokines on BK-induced Ca(2+) response.	Prostaglandins	80-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-70
26213094-0	2015	Biphenyl-2,4,6,3",5"-pentacarboxylic acid as a tecton for six new Co(II) coordination polymers: pH and N-donor ligand-dependent assemblies, structure diversities and magnetic properties.	biphenyl-2,4,6,3",5"-pentacarboxylic acid	0-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-72
26280846-10	2015	Using electron paramagnetic resonance (EPR) spectroscopy and density functional theory (DFT), it was determined that one-electron oxidation of [Co2(L(N3O2)) (bpy)2](+) results in formation of a S = 1/2 species with a L(N3O2)-based radical coupled to low-spin Co(II) centers.	co2(l(n3o2)) (bpy)2	144-163	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	259-265
26213094-0	2015	Biphenyl-2,4,6,3",5"-pentacarboxylic acid as a tecton for six new Co(II) coordination polymers: pH and N-donor ligand-dependent assemblies, structure diversities and magnetic properties.	Nitrogen	103-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-72
26087400-7	2015	Furthermore, COX2 inhibitor celecoxib strongly reduced growth and invasiveness following hypoxic PCA cells reoxygenation, and inhibited invasiveness induced by hypoxic PCA EVs.	Celecoxib	28-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-17
25633180-7	2015	17-AAG pretreatment induced the degradation of upstream regulators of IkappaB, IL-1R-associated kinase-1 (IRAK-1), and IkappaB kinases (IKKs), dose and time dependently, which resulted in blocking of PS-341-induced IkappaBalpha degradation, p65 nuclear translocation, transcriptional activity, and NF-kappaB-regulated antiapoptotic gene expressions such as COX-2.	tanespimycin	0-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	357-362
25932976-2	2015	Single crystal X-ray structure reveals that in 1, the adjacent Co(II) and Co(III) ions are linked by double end-on azido bridges and thus the full molecule is generated by the site symmetry of a crystallographic twofold rotation axis.	3',5-diazido-2',3'-dideoxyuridine	115-120	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-69
26229042-0	2015	Field-induced slow relaxation of magnetization in a pentacoordinate Co(II) compound [Co(phen)(DMSO)Cl2].	co(phen)(dmso)cl2	85-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-74
26102077-0	2015	Betulinic acid exerts anti-hepatitis C virus activity via the suppression of NF-kappaB- and MAPK-ERK1/2-mediated COX-2 expression.	betulinic acid	0-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-118
26139640-2	2015	Celecoxib, a nonsteroidal anti-inflammatory drug, which acts via the selective inhibition of cyclo-oxygenase (COX)-2, has been shown to have antidepressive effects.	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-116
26139640-3	2015	OBJECTIVES: Here, we aimed to compare the efficacy and safety of celecoxib, a selective inhibitor of COX-2, with diclofenac, a nonselective inhibitor of both COX-1 and COX-2 in reducing depressive symptoms and pain in breast cancer patients.	Celecoxib	65-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-106
26102077-8	2015	Exogenous overexpression of COX-2 gradually attenuated the inhibitory effect of BA on HCV replication, suggesting that BA reduces HCV replication by suppressing the expression of COX-2.	betulinic acid	119-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
26102077-8	2015	Exogenous overexpression of COX-2 gradually attenuated the inhibitory effect of BA on HCV replication, suggesting that BA reduces HCV replication by suppressing the expression of COX-2.	betulinic acid	119-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	179-184
26140661-4	2015	KEY RESULTS: In dHUVEC treated with IL-1beta, the expression of COX-2 mRNA and protein was enhanced and generation of prostanoids increased (the most abundant was the promitogenic PGF2alpha ).	dhuvec	16-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-69
26102077-9	2015	In particular, BA down-regulated HCV-induced COX-2 expression by reducing the phosphorylation of NF-kappaB and ERK1/2 of the MAPK signalling pathway.	betulinic acid	15-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-50
26102077-8	2015	Exogenous overexpression of COX-2 gradually attenuated the inhibitory effect of BA on HCV replication, suggesting that BA reduces HCV replication by suppressing the expression of COX-2.	betulinic acid	80-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
26140661-4	2015	KEY RESULTS: In dHUVEC treated with IL-1beta, the expression of COX-2 mRNA and protein was enhanced and generation of prostanoids increased (the most abundant was the promitogenic PGF2alpha ).	Dinoprost	180-189	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-69
26140661-5	2015	COX-2 mRNA was more stable in dHUVEC and this was associated with miR-16 down-regulation and c-Myc induction (a suppressor of miR expression).	dhuvec	30-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
26140661-6	2015	dHUVEC showed increased proliferation in response to IL-1beta, which was prevented by a COX-2 inhibitor and PGF2alpha receptor antagonist.	dhuvec	0-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-93
26140661-7	2015	Comparable changes in COX-2 mRNA, miR-16 and c-Myc detected in dHUVEC were produced in nHUVEC exposed to transient high glucose and then stimulated with IL-1beta under physiological glucose levels; superoxide anion production was enhanced under these experimental conditions.	dhuvec	63-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-27
26140661-7	2015	Comparable changes in COX-2 mRNA, miR-16 and c-Myc detected in dHUVEC were produced in nHUVEC exposed to transient high glucose and then stimulated with IL-1beta under physiological glucose levels; superoxide anion production was enhanced under these experimental conditions.	Glucose	120-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-27
26140661-7	2015	Comparable changes in COX-2 mRNA, miR-16 and c-Myc detected in dHUVEC were produced in nHUVEC exposed to transient high glucose and then stimulated with IL-1beta under physiological glucose levels; superoxide anion production was enhanced under these experimental conditions.	Glucose	182-189	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-27
26102077-8	2015	Exogenous overexpression of COX-2 gradually attenuated the inhibitory effect of BA on HCV replication, suggesting that BA reduces HCV replication by suppressing the expression of COX-2.	betulinic acid	80-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	179-184
26140661-7	2015	Comparable changes in COX-2 mRNA, miR-16 and c-Myc detected in dHUVEC were produced in nHUVEC exposed to transient high glucose and then stimulated with IL-1beta under physiological glucose levels; superoxide anion production was enhanced under these experimental conditions.	Superoxides	198-214	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-27
26140661-8	2015	CONCLUSIONS AND IMPLICATIONS: Our results describe a possible mechanism operating in GDM that links the enhanced superoxide anion production and epigenetic changes, associated with hyperglycaemic memory, to endothelial dysfunction through dysregulated post-transcriptional control of COX-2 gene expression in response to inflammatory stimuli.	Superoxides	113-129	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	284-289
26036909-0	2015	The TLR-2/TLR-6 agonist macrophage-activating lipopeptide-2 augments human NK cell cytotoxicity when PGE2 production by monocytes is inhibited by a COX-2 blocker.	Dinoprostone	101-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	148-153
25380191-8	2015	This review synthesizes the evidence on the COX-2-independent mechanisms of action of aspirin, salicylates, and other NSAIDs on breast cancer.	Aspirin	86-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-49
27137142-10	2015	Acetaminophen and indomethacin inhibited COX-1 and COX-2 following a single dose, but acetaminophen was a less potent COX-1 inhibitor than indomethacin.	Acetaminophen	0-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-56
27137142-10	2015	Acetaminophen and indomethacin inhibited COX-1 and COX-2 following a single dose, but acetaminophen was a less potent COX-1 inhibitor than indomethacin.	Indomethacin	18-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-56
24639330-2	2015	Previously, we found that Pb(2+) ions induce COX-2 gene expression via the EGF receptor/nuclear factor-kappaB signal transduction pathway in epidermoid carcinoma cell line A431.	Lead	26-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-50
24639330-3	2015	In this study, to see whether Pb(2+) ions affect COX-2 expression by epigenetic mechanisms, we looked at the mRNAs of DNA methyltransferases (DNMTs) using real-time PCR of total RNA from these cells.	Lead	30-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-54
24639330-5	2015	Pretreatment of cells with DNMT inhibitor 5-aza-2"-deoxycytidine (5 muM) followed by Pb(2+) (1 muM) significantly increased levels of COX-2 mRNA compared with cells treated with Pb(2+) alone.	Decitabine	42-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-139
24639330-5	2015	Pretreatment of cells with DNMT inhibitor 5-aza-2"-deoxycytidine (5 muM) followed by Pb(2+) (1 muM) significantly increased levels of COX-2 mRNA compared with cells treated with Pb(2+) alone.	Lead	85-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-139
25380191-8	2015	This review synthesizes the evidence on the COX-2-independent mechanisms of action of aspirin, salicylates, and other NSAIDs on breast cancer.	Salicylates	95-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-49
24639330-5	2015	Pretreatment of cells with DNMT inhibitor 5-aza-2"-deoxycytidine (5 muM) followed by Pb(2+) (1 muM) significantly increased levels of COX-2 mRNA compared with cells treated with Pb(2+) alone.	Lead	178-180	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-139
26201059-6	2015	Acetylation of COX-2 allows for generation of 15-(R)HETE and subsequent formation of "aspirin-triggered lipoxin" (ATL) by interaction with white cell lipoxygenases.	Aspirin	86-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-20
24639330-10	2015	Our findings suggest Pb(2+) ions induce COX-2 expression indirectly by reducing DNMT3a methylation of the COX-2 promoter via transcription factors Rb and E2F1.	Lead	21-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
24639330-10	2015	Our findings suggest Pb(2+) ions induce COX-2 expression indirectly by reducing DNMT3a methylation of the COX-2 promoter via transcription factors Rb and E2F1.	Lead	21-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-111
25239119-8	2015	Besides, the survival benefit of postdiagnosis aspirin use appeared to be confined to those patients with positive prostaglandin endoperoxide synthase 2 (PTGS2, also known as cyclooxygenase-2, COX-2) expression (HR=0.65, 95% CI 0.50 to 0.85) and with mutated PIK3CA tumours (HR=0.58, 95% CI 0.37 to 0.90).	Aspirin	47-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	193-198
25239119-11	2015	CONCLUSIONS: These findings provide further indication that postdiagnosis aspirin therapy improved CRC overall survival, especially for patients with positive PTGS2 (COX-2) expression and mutated PIK3CA tumours.	Aspirin	74-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	166-171
26617722-15	2015	Overexpression of miR-101 decreased expression of its target gene Cox-2 and inhibited proliferation and invasion, and promoted apoptosis to suppress tumorigenicity.	mir-101	18-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-71
25981877-3	2015	Metformin may harbor a pleiotropic action, (a) decreasing inflammation (via anti COX 2 pathway and other mechanism), (b) decreasing COX 2 and VEGF mediated angiogenesis, (c) increasing negative angiogenic regulation pathway by stimulating SMAD 2/3 expression either directly or via the AMPK pathway and preventing from pulmonary hypertension development and (d) diminushin oxidative stress.	Metformin	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-86
25981877-3	2015	Metformin may harbor a pleiotropic action, (a) decreasing inflammation (via anti COX 2 pathway and other mechanism), (b) decreasing COX 2 and VEGF mediated angiogenesis, (c) increasing negative angiogenic regulation pathway by stimulating SMAD 2/3 expression either directly or via the AMPK pathway and preventing from pulmonary hypertension development and (d) diminushin oxidative stress.	Metformin	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-137
26081696-7	2015	The results of the present study demonstrated that elevation in the ratio of AA to PGE2 via suppression of the protein expression of cPLA2 and COX-2 in the AA metabolic pathway is involved in the inhibitory effect of BBR in HCC.	Dinoprostone	83-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	143-148
25962348-5	2015	COX-2 expression was evaluated by indirect streptavidin biotin method.	Biotin	56-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
26085050-6	2015	For example, aspirin at antiplatelet doses might acetylate COX-2 in vascular cells, directing the activity of the enzyme into a 15-lipoxygenase which by transcellular metabolism results in the formation of 15-epi-lipoxin ( aspirin-triggered lipoxin ), an antiinflammatory mediator.	Aspirin	13-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-64
26363168-11	2015	Conversely, autophagy inhibition by 3-methyladenine enhanced COX-2 expression.	3-methyladenine	36-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-66
26085050-6	2015	For example, aspirin at antiplatelet doses might acetylate COX-2 in vascular cells, directing the activity of the enzyme into a 15-lipoxygenase which by transcellular metabolism results in the formation of 15-epi-lipoxin ( aspirin-triggered lipoxin ), an antiinflammatory mediator.	15-epi-lipoxin	206-220	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-64
26085050-6	2015	For example, aspirin at antiplatelet doses might acetylate COX-2 in vascular cells, directing the activity of the enzyme into a 15-lipoxygenase which by transcellular metabolism results in the formation of 15-epi-lipoxin ( aspirin-triggered lipoxin ), an antiinflammatory mediator.	Aspirin	223-230	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-64
26085050-6	2015	For example, aspirin at antiplatelet doses might acetylate COX-2 in vascular cells, directing the activity of the enzyme into a 15-lipoxygenase which by transcellular metabolism results in the formation of 15-epi-lipoxin ( aspirin-triggered lipoxin ), an antiinflammatory mediator.	Lipoxins	213-220	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-64
26270596-0	2015	Reactivity of Hydride Bridges in High-Spin [3M-3(mu-H)] Clusters (M = FeII, CoII).	Creatinine	14-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-80
26197159-0	2015	Synthesis of new 4-phenylpyrimidine-2(1H)-thiones and their potency to inhibit COX-1 and COX-2.	4-phenylpyrimidine-2(1h)-thiones	17-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-94
26197159-1	2015	Several new 4-phenylpyrimidine-2(1H)-thiones have been prepared and investigated for their potencies to inhibit COX-1 and COX-2 enzymes, and COX-2 expression in THP-1 cells.	4-phenylpyrimidine-2(1h)-thiones	12-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-127
26197159-1	2015	Several new 4-phenylpyrimidine-2(1H)-thiones have been prepared and investigated for their potencies to inhibit COX-1 and COX-2 enzymes, and COX-2 expression in THP-1 cells.	4-phenylpyrimidine-2(1h)-thiones	12-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	141-146
26225623-2	2015	Thin films of polyCo, based on bisterpyridine ligand assembled with Co(II) metal ion, were constructed by spray casting the polymer onto ITO glass.	polyco	14-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-74
26225623-3	2015	With such simple fabricating means to form good-quality films, polyCo films show stable switching at the central metal ion of the Co(II)/Co(I) redox reaction when immersed in aqueous solution.	Metals	113-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	130-136
26270596-1	2015	The designed [3M-3(mu-H)] clusters (M = Fe(II), Co(II)) Fe3H3L (1-H) and Co3H3L (2-H) [where L(3-) is a tris(beta-diketiminate) cyclophane] were synthesized by treating the corresponding M3Br3L complexes with KBEt3H.	fe3h3l	56-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-54
25827764-1	2015	The crystal structure of a new coordination compound tri(2-(2,6-dichlorophenyl)-1H-imidazo[4,5-f][1,10]phenanthroline) Co(II) complex ([Co(dcpip)3]Cl2) was measured with X-ray diffraction measurements.	co(dcpip)3]cl2)	136-151	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-125
26213196-8	2015	Combined experimental and theoretical study suggest a formal Co(II)-hydride species as a key intermediate that triggers H2 generation.	Hydrogen	120-122	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-67
33435084-4	2015	It was confirmed that both Co(II) and Cr(III) ions, and their combination, at concentrations relevant for the metal release situation, resulted in protein aggregation and its concomitant precipitation, which increased the friction coefficient.	Metals	110-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-33
26253302-4	2015	METHODS: Magnolin-mediated signaling inhibition was confirmed by Western blotting using RSK2(+/+) and RSK2(-/-) MEFs, A549 and NCI-H1975 lung cancer cells, and by NF-kappaB and Cox-2 promoter luciferase reporter assays.	magnolin	9-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	177-182
26253302-8	2015	Moreover, magnolin abrogated the increase in EGF-induced COX-2 protein levels and wound healing.	magnolin	10-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-62
26307959-0	2015	Design and Synthesis of Imidazopyrazolopyridines as Novel Selective COX-2 Inhibitors.	imidazopyrazolopyridines	24-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-73
26307959-7	2015	In the present study, we introduced imidazopyrazolopyridines as new potent and selective COX-2 inhibitors that lack the standard pharmacophoric binding features to hERG.	imidazopyrazolopyridines	36-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-94
25827270-0	2015	Co(II)-grafted Ag3PO4 photocatalysts with unexpected photocatalytic ability: Enhanced photogenerated charge separation efficiency, photocatalytic mechanism and activity.	ag3po4	15-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
25827270-2	2015	Here, we made large improvement on the surface of Ag3PO4 using Co(II)-grafted Ag3PO4 by a hydrothermal method.	ag3po4	50-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-69
25827270-2	2015	Here, we made large improvement on the surface of Ag3PO4 using Co(II)-grafted Ag3PO4 by a hydrothermal method.	ag3po4	78-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-69
25827270-5	2015	The synergy of Co(II) and Ag3PO4 greatly promoted the separation and transmission efficiency of the photogenerated charges, and severely improved the photocatalytic activity of Ag3PO4.	ag3po4	177-183	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-21
25827270-6	2015	The surface grafted Co(II) on Ag3PO4 is responsible for the enhancement of photocatalytic activity.	ag3po4	30-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-26
26158563-2	2015	The Co(II)/sarcosine catalytic system is shown to perform efficiently when phenyl and benzyl Grignards are coupled with alkenyl bromides.	Sarcosine	11-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
26158563-2	2015	The Co(II)/sarcosine catalytic system is shown to perform efficiently when phenyl and benzyl Grignards are coupled with alkenyl bromides.	alkenyl bromides	120-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
26158563-3	2015	Notably, previously unachievable Co-catalyzed coupling of allylic bromides with Grignards to linearly coupled alpha-products was also realized with Co(II)/sarcosine catalyst.	allylic bromides	58-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	148-154
26158563-3	2015	Notably, previously unachievable Co-catalyzed coupling of allylic bromides with Grignards to linearly coupled alpha-products was also realized with Co(II)/sarcosine catalyst.	Sarcosine	155-164	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	148-154
25827764-3	2015	The ligand, 2-(2,6-dichlorophenyl)-1H-imidazo[4,5-f][1,10]phenanthroline(dcpip), binds to Co(II) ions with a bis-dentate mode, and each Co(II) ion with a distorted octahedral coordination geometry.	2-(2,6-dichlorophenyl)-1h-imidazo[4,5-f][1,10]phenanthroline	12-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-96
25827764-3	2015	The ligand, 2-(2,6-dichlorophenyl)-1H-imidazo[4,5-f][1,10]phenanthroline(dcpip), binds to Co(II) ions with a bis-dentate mode, and each Co(II) ion with a distorted octahedral coordination geometry.	2-(2,6-dichlorophenyl)-1h-imidazo[4,5-f][1,10]phenanthroline	12-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	136-142
25827764-3	2015	The ligand, 2-(2,6-dichlorophenyl)-1H-imidazo[4,5-f][1,10]phenanthroline(dcpip), binds to Co(II) ions with a bis-dentate mode, and each Co(II) ion with a distorted octahedral coordination geometry.	1,3-dihydroxypropan-2-one 1,3-diiopanoate	73-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-96
25827764-3	2015	The ligand, 2-(2,6-dichlorophenyl)-1H-imidazo[4,5-f][1,10]phenanthroline(dcpip), binds to Co(II) ions with a bis-dentate mode, and each Co(II) ion with a distorted octahedral coordination geometry.	1,3-dihydroxypropan-2-one 1,3-diiopanoate	73-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	136-142
25827764-3	2015	The ligand, 2-(2,6-dichlorophenyl)-1H-imidazo[4,5-f][1,10]phenanthroline(dcpip), binds to Co(II) ions with a bis-dentate mode, and each Co(II) ion with a distorted octahedral coordination geometry.	bis-dentate	109-120	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-96
25827773-0	2015	Synthesis, spectral, antitumor, antioxidant and antimicrobial studies on Cu(II), Ni(II) and Co(II) complexes of 4-[(1H-Benzoimidazol-2-ylimino)-methyl]-benzene-1,3-diol.	cu(ii)	73-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-98
25827773-0	2015	Synthesis, spectral, antitumor, antioxidant and antimicrobial studies on Cu(II), Ni(II) and Co(II) complexes of 4-[(1H-Benzoimidazol-2-ylimino)-methyl]-benzene-1,3-diol.	4-[(1h-benzoimidazol-2-ylimino)-methyl]-benzene-1,3-diol	112-168	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-98
25827773-1	2015	A new Schiff base of 2-aminobenzimidazole with 2,4-dihydroybezaldehyde (H3L), and its Cu(II), Ni(II) and Co(II) complexes have been synthesized and characterized by elemental analyses, molar conductance, thermal analysis (TGA), inductive coupled plasma (ICP), magnetic moment measurements, IR, EI-mass, UV-Vis.	Schiff Bases	6-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-111
25827773-1	2015	A new Schiff base of 2-aminobenzimidazole with 2,4-dihydroybezaldehyde (H3L), and its Cu(II), Ni(II) and Co(II) complexes have been synthesized and characterized by elemental analyses, molar conductance, thermal analysis (TGA), inductive coupled plasma (ICP), magnetic moment measurements, IR, EI-mass, UV-Vis.	2-aminobenzimidazole	21-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-111
25827773-1	2015	A new Schiff base of 2-aminobenzimidazole with 2,4-dihydroybezaldehyde (H3L), and its Cu(II), Ni(II) and Co(II) complexes have been synthesized and characterized by elemental analyses, molar conductance, thermal analysis (TGA), inductive coupled plasma (ICP), magnetic moment measurements, IR, EI-mass, UV-Vis.	h3l	72-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-111
25841152-3	2015	The thermal activation energies of decomposition (Ea) of HL and its metal complexes with Cu(II), Co(II) and Ni(II) are found to be 48.76, 36.83, 30.59 and 40.45 kJ/mol, respectively.	Metals	68-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-103
26047642-4	2015	Here we show that bradykinin (BK) stimulation of HASMC increases amphiregulin secretion in a mechanism dependent on BK-induced COX-2 expression, increased PGE2 output, and the stimulation of HASMC EP2 and EP4 receptors.	hasmc	49-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	127-132
26047642-5	2015	Conditioned medium from BK treated HASMC induced CXCL8, VEGF, and COX-2 mRNA and protein accumulation in airway epithelial cells, which were blocked by anti-amphiregulin antibodies and amphiregulin siRNA, suggesting a paracrine effect of HASMC-derived amphiregulin on airway epithelial cells.	hasmc	35-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-71
26047642-8	2015	Our study provides evidence of a dynamic axis of interaction between HASMC and epithelial cells that amplifies CXCL8, VEGF, COX-2, and amphiregulin production.	hasmc	69-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	124-129
26190093-5	2015	Resveratrol"s primary targets appear to be the transcription factors AP-1 and NF-kappaB, as well as the gene COX2.	Resveratrol	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-113
26048794-3	2015	Molecular docking analyses demonstrated that an isoleucine residue in the active site of COX1 is responsible for lower affinity to COX1 and increased potency towards COX2.	Isoleucine	48-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	166-170
26056075-0	2015	Aflibercept, bevacizumab and ranibizumab prevent glucose-induced damage in human retinal pericytes in vitro, through a PLA2/COX-2/VEGF-A pathway.	Glucose	49-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	124-129
26056075-2	2015	Here we tested two hypotheses: (i) high glucose damages retinal pericytes, the cell layer surrounding endothelial cells, via VEGF induction, which may be counteracted by anti-VEGFs and (ii) activation of PLA2/COX-2 pathway by high glucose might be upstream and/or downstream of VEGF in perycites, as previously observed in endothelial cells.	Glucose	40-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	209-214
26056075-6	2015	High glucose induced also activation of PLA2/COX-2 pathway, as revealed by increased phosphorylation of cPLA2, COX-2 expression and PGE2 release.	Glucose	5-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-50
26056075-6	2015	High glucose induced also activation of PLA2/COX-2 pathway, as revealed by increased phosphorylation of cPLA2, COX-2 expression and PGE2 release.	Glucose	5-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	111-116
26056075-6	2015	High glucose induced also activation of PLA2/COX-2 pathway, as revealed by increased phosphorylation of cPLA2, COX-2 expression and PGE2 release.	Dinoprostone	132-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-50
26056075-7	2015	Treatment with cPLA2 (50muM AACOCF3) and COX-2 (5muM NS-392) inhibitors prevented both cell damage and VEGF-A induced by high glucose.	ns-392	53-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-46
26056075-7	2015	Treatment with cPLA2 (50muM AACOCF3) and COX-2 (5muM NS-392) inhibitors prevented both cell damage and VEGF-A induced by high glucose.	Glucose	126-133	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-46
26056075-9	2015	These data indicate that high glucose directly damages pericytes through activation of PLA2/COX-2/VEGF-A pathway.	Glucose	30-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-97
26254051-6	2015	However, there is cross-reactivity between the NSAIDs in patients with NSAID-exacerbated cutaneous disease and NIUA, and thus only use of selective COX-2 inhibitors can replace the culprit drug if the chronic treatment is necessary, although aspirin desensitization will allow for chronic treatment with NSAIDs in some patients with NIUA.	niua	111-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	148-153
26254051-6	2015	However, there is cross-reactivity between the NSAIDs in patients with NSAID-exacerbated cutaneous disease and NIUA, and thus only use of selective COX-2 inhibitors can replace the culprit drug if the chronic treatment is necessary, although aspirin desensitization will allow for chronic treatment with NSAIDs in some patients with NIUA.	Aspirin	242-249	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	148-153
26254051-6	2015	However, there is cross-reactivity between the NSAIDs in patients with NSAID-exacerbated cutaneous disease and NIUA, and thus only use of selective COX-2 inhibitors can replace the culprit drug if the chronic treatment is necessary, although aspirin desensitization will allow for chronic treatment with NSAIDs in some patients with NIUA.	niua	333-337	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	148-153
25955644-6	2015	Treatment with gallic acid was observed to significantly mitigate SCI-induced oxidative stress and the inflammatory response by reducing the oxidative stress, decreasing the expression of NF-kappaB and COX-2 as well as increasing the antioxidant status of cells.	Gallic Acid	15-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	202-207
26135905-0	2015	Mn(II)- and Co(II)-Catalyzed Transformation of 2-Cyanopyrimidine to Methylimidate by Sodium Azide: Isolation, Structural Characterization, and Magnetic Studies on 2D Mn(II)- and Cu(II)-Complexes.	4-amino-5-pyrimidinecarbonitrile	47-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-18
26135905-0	2015	Mn(II)- and Co(II)-Catalyzed Transformation of 2-Cyanopyrimidine to Methylimidate by Sodium Azide: Isolation, Structural Characterization, and Magnetic Studies on 2D Mn(II)- and Cu(II)-Complexes.	methylimidate	68-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-18
26135905-0	2015	Mn(II)- and Co(II)-Catalyzed Transformation of 2-Cyanopyrimidine to Methylimidate by Sodium Azide: Isolation, Structural Characterization, and Magnetic Studies on 2D Mn(II)- and Cu(II)-Complexes.	Sodium Azide	85-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-18
26135905-0	2015	Mn(II)- and Co(II)-Catalyzed Transformation of 2-Cyanopyrimidine to Methylimidate by Sodium Azide: Isolation, Structural Characterization, and Magnetic Studies on 2D Mn(II)- and Cu(II)-Complexes.	Manganese(2+)	166-172	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-18
26135905-0	2015	Mn(II)- and Co(II)-Catalyzed Transformation of 2-Cyanopyrimidine to Methylimidate by Sodium Azide: Isolation, Structural Characterization, and Magnetic Studies on 2D Mn(II)- and Cu(II)-Complexes.	cu(ii)	178-184	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-18
26135905-3	2015	The catalytic nature of this transformation reaction was confirmed by performing these experiments under catalytic conditions and analyzing the products using liquid chromatography-mass spectrometry techniques, which clearly showed ~96% and ~60% selectivity of methylimidate along with almost 100% conversion in the presence of Mn(II) and Co(II) as catalysts, respectively.	methylimidate	261-274	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	339-345
26135905-3	2015	The catalytic nature of this transformation reaction was confirmed by performing these experiments under catalytic conditions and analyzing the products using liquid chromatography-mass spectrometry techniques, which clearly showed ~96% and ~60% selectivity of methylimidate along with almost 100% conversion in the presence of Mn(II) and Co(II) as catalysts, respectively.	Manganese(2+)	328-334	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	339-345
26193270-0	2015	A New Ligustrazine Derivative-Selective Cytotoxicity by Suppression of NF-kappaB/p65 and COX-2 Expression on Human Hepatoma Cells.	tetramethylpyrazine	6-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-94
26221076-8	2015	Icariside II has been found to induce apoptosis in various human cancer cell lines of different origin by targeting multiple signaling pathways including STAT3, PI3K/AKT, MAPK/ERK, COX-2/PGE2 and beta-Catenin which are frequently deregulated in cancers, suggesting that this collective activity rather than just a single effect may play an important role in developing Icariside II into a potential lead compound for anticancer therapy.	baohuoside I	0-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	181-186
26033709-1	2015	The reaction of the chiral dipeptide glycyl-L(S)-glutamate with Co(II) ions produces chiral ladders that can be used as rigid 1D building units.	Dipeptides	27-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-70
26033709-1	2015	The reaction of the chiral dipeptide glycyl-L(S)-glutamate with Co(II) ions produces chiral ladders that can be used as rigid 1D building units.	glycyl-l(s)-glutamate	37-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-70
26043416-0	2015	Triimidosulfonates as Acute Bite-Angle Chelates: Slow Relaxation of the Magnetization in Zero Field and Hysteresis Loop of a Co(II) Complex.	triimidosulfonates	0-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-131
26043416-1	2015	Starting from a polyimido sulfonate the four-coordinate, N,N"-chelated Co(II) complex [Co{(NtBu)3 SMe}2 ] (1) was synthesized, and its molecular structure was elucidated by single-crystal X-ray structural analysis.	polyimido sulfonate	16-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-77
26043416-1	2015	Starting from a polyimido sulfonate the four-coordinate, N,N"-chelated Co(II) complex [Co{(NtBu)3 SMe}2 ] (1) was synthesized, and its molecular structure was elucidated by single-crystal X-ray structural analysis.	co{(ntbu)3 sme	87-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-77
26043416-2	2015	The acute N-Co-N bite angle imposed by the N,N"-chelating ligand (NtBu)3 SMe(-) leads to pronounced C2v distortion of the tetrahedral coordination environment and thus to high anisotropy of the Co(II) ion (D -58 cm(-1) ), favorable for single-molecule-magnet (SMM) properties.	n-co-n	10-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	194-200
25913073-4	2015	TiO2 NPs significantly enhanced the IL-1beta-induced prostaglandin E2 production and COX-1 and COX-2 protein expression.	titanium dioxide	0-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-100
26130144-21	2015	Since a study of a selective COX-2 inhibitor NSAID (valdecoxib) that was subsequently withdrawn from the market dominates the evidence for this comparison (706 participants included in the analyses for pain, function and gastrointestinal adverse events), the applicability of these results is in doubt and we give only a brief summary.	valdecoxib	52-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34
26122769-0	2015	Structure Based Library Design (SBLD) for new 1,4-dihydropyrimidine scaffold as simultaneous COX-1/COX-2 and 5-LOX inhibitors.	1,4-dihydropyrimidine	46-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-110
26122769-1	2015	The various scaffolds containing 1,4-dihydropyrimidine ring were designed by considering the environment of the active site of COX-1/COX-2 and 5-LOX enzymes.	1,4-dihydropyrimidine	33-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	133-144
26349982-4	2015	Mechanistic studies revealed that BDMC-A might have exerted its activity by inhibiting metastatic and angiogenic pathways by modulating the expression of proteins upstream to NF-kappaB (TGF-beta, TNF-alpha, IL-1beta and c-Src), and NF-kappaB signaling cascade (c-Rel, COX-2, MMP-9, VEGF, IL-8) and by upregulating TIMP-2 levels.	BDMC-A	34-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	268-273
25869511-9	2015	Therefore, nonselective COX inhibition with ASA 325mg and ibuprofen completely inhibit the protective effects of rosuvastatin in the setting of IR injury, as does therapy with the specific COX-2 antagonist celecoxib.	Celecoxib	206-215	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	189-194
26183281-7	2015	Moreover, secretion of PGE2 was considerably reduced by treatment with the COX-2 inhibitor Valdecoxib, demonstrating the functional utility of our newly established monolayer for preclinical therapeutic assays.	Dinoprostone	23-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
26183281-7	2015	Moreover, secretion of PGE2 was considerably reduced by treatment with the COX-2 inhibitor Valdecoxib, demonstrating the functional utility of our newly established monolayer for preclinical therapeutic assays.	valdecoxib	91-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
26073883-0	2015	Strong Direct Magnetic Coupling in a Dinuclear Co(II) Tetrazine Radical Single-Molecule Magnet.	tetrazine radical	54-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-53
26430505-10	2015	Electron-rich phospholanes, bis-oxazolines and N-heterocyclic carbenes appear to be poor ligands for the Co(II)-catalysed hydrovinylation of 1,3-dienes.	phospholanes	14-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-110
26430505-10	2015	Electron-rich phospholanes, bis-oxazolines and N-heterocyclic carbenes appear to be poor ligands for the Co(II)-catalysed hydrovinylation of 1,3-dienes.	bis-oxazolines	28-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-110
26430505-10	2015	Electron-rich phospholanes, bis-oxazolines and N-heterocyclic carbenes appear to be poor ligands for the Co(II)-catalysed hydrovinylation of 1,3-dienes.	1,3-dienes	141-151	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-110
26048794-4	2015	Overall, our study reveals that the new 1,2-oxazine-based small molecules qualify as lead structures in developing COX2-specific inhibitors for anti-inflammatory therapy.	1,2-oxazine	40-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-119
26117823-2	2015	The results of the ETM-NN calculations allowed for the selection of pharmacophoric molecular fragments, which could be taken as a basis for a system capable of predicting the COX-2/5-LOX inhibitory activity.	etm-nn	19-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	175-180
26117823-6	2015	The system for the selective COX-2/5-LOX inhibitory activity prediction that has been developed as the result of the ETM-NN study recognized correctly 93% of compounds as highly active ones.	etm-nn	117-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34
25792567-6	2015	Both in monovulatory and poliovulatory species, the increase in PGE2 production induced by NO via a stimulatory effect on COX-2 activity appears to be a common ovulatory mechanism.	Dinoprostone	64-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-127
26072731-6	2015	Increased prostacyclin (PGI2) via COX-1 and COX-2 overexpression, and increased EETs/heme-oxygenase-1/K channels/gap junctions (endothelial derived hyperpolarizing factor system) play a major role in mesenteric vasodilatation, hyporeactivity to vasoconstrictors, and hyper-response to vasodilators.	Epoprostenol	24-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-49
25585956-0	2015	Enhanced Anti-Angiogenic Effect of Low Molecular Weight Heparin-Bile Acid Conjugates by Co-Administration of a Selective COX-2 Inhibitor.	Heparin	56-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-126
25585956-0	2015	Enhanced Anti-Angiogenic Effect of Low Molecular Weight Heparin-Bile Acid Conjugates by Co-Administration of a Selective COX-2 Inhibitor.	Bile Acids and Salts	64-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-126
25585956-3	2015	RESULTS: While hypoxia-mediated COX-2 overexpression and macrophage recruitment were observed at LHT7-treated tumor tissues, it was well-controlled by the combination of celecoxib and LHT7.	lht7	97-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-37
26041519-4	2015	The usefulness of this sensor was tested by Ni(II) and Co(II) traces determination by means of differential pulse adsorptive stripping voltammetry (DP AdSV), after complexation with dimethylglyoxime (DMG) in ammonia buffer (pH 8.2).	dp	148-150	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-61
26041519-4	2015	The usefulness of this sensor was tested by Ni(II) and Co(II) traces determination by means of differential pulse adsorptive stripping voltammetry (DP AdSV), after complexation with dimethylglyoxime (DMG) in ammonia buffer (pH 8.2).	dimethylglyoxime	182-198	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-61
26041519-4	2015	The usefulness of this sensor was tested by Ni(II) and Co(II) traces determination by means of differential pulse adsorptive stripping voltammetry (DP AdSV), after complexation with dimethylglyoxime (DMG) in ammonia buffer (pH 8.2).	dimethylglyoxime	200-203	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-61
26041519-4	2015	The usefulness of this sensor was tested by Ni(II) and Co(II) traces determination by means of differential pulse adsorptive stripping voltammetry (DP AdSV), after complexation with dimethylglyoxime (DMG) in ammonia buffer (pH 8.2).	Ammonia	208-215	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-61
26013160-4	2015	Significantly, the transmetalation of Co(II) or Ni(II) on the Zn(II) centers in 446-MOF can enhance the sorption capacities of CO2 and CH4 (16-21%), whereas the impregnation of Eu(III) and Tb(III) in the channels of 446-MOF will result in adjustable light-emitting behaviors.	Zinc	62-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-44
26009874-9	2015	In a combination regimen, Sabutoclax and COX-2 inhibitor, Celecoxib, synergistically inhibited the growth of OSCC in vitro and also significantly reduced OSCC tumor growth in vivo.	Celecoxib	58-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-46
26013160-4	2015	Significantly, the transmetalation of Co(II) or Ni(II) on the Zn(II) centers in 446-MOF can enhance the sorption capacities of CO2 and CH4 (16-21%), whereas the impregnation of Eu(III) and Tb(III) in the channels of 446-MOF will result in adjustable light-emitting behaviors.	N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)-4-((4-fluorobenzyl)oxy)pyridine-2,6-dicarboxamide	127-130	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-44
26013160-4	2015	Significantly, the transmetalation of Co(II) or Ni(II) on the Zn(II) centers in 446-MOF can enhance the sorption capacities of CO2 and CH4 (16-21%), whereas the impregnation of Eu(III) and Tb(III) in the channels of 446-MOF will result in adjustable light-emitting behaviors.	Methane	135-138	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-44
26013160-4	2015	Significantly, the transmetalation of Co(II) or Ni(II) on the Zn(II) centers in 446-MOF can enhance the sorption capacities of CO2 and CH4 (16-21%), whereas the impregnation of Eu(III) and Tb(III) in the channels of 446-MOF will result in adjustable light-emitting behaviors.	Terbium	189-191	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-44
26018933-4	2015	The mutants allow us to demonstrate convincingly the preparation of a mixed-metal analogue, Co(C)Zn(S)-MMP-1, with Zn(II) in the structural site and Co(II) in the catalytic site.	Metals	76-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	149-155
25906749-7	2015	Licofelone suppressed pancreatic tumor COX-2 and 5-LOX activities and modulated miRNAs characteristic of CSC and inflammation in correlation with PDAC inhibition.	licofelone	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-50
26018933-4	2015	The mutants allow us to demonstrate convincingly the preparation of a mixed-metal analogue, Co(C)Zn(S)-MMP-1, with Zn(II) in the structural site and Co(II) in the catalytic site.	co(c)zn	92-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	149-155
26113985-3	2015	The calcium influx triggered by TRPV1 activation in endothelial cells mimics the impact of shear stress in this regard, activating and increasing the expression of eNOS-but also increasing expression of cox-2, thrombomodulin, and nrf2-responsive antioxidant enzymes, while decreasing expression of proinflammatory proteins.	Calcium	4-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	203-208
27980965-2	2015	For example, by utilizing the valence change from Co(III) to Co(II) in MgCo2O4, Mg insertion occurs at a considerably high potential of about 2.9 V vs. Mg2+/Mg, and similarly it occurs around 2.3 V vs. Mg2+/Mg with the valence change from Mn(III) to Mn(II) in MgMn2O4, being comparable to the ab initio calculation.	mgco2o4	71-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-67
27980965-2	2015	For example, by utilizing the valence change from Co(III) to Co(II) in MgCo2O4, Mg insertion occurs at a considerably high potential of about 2.9 V vs. Mg2+/Mg, and similarly it occurs around 2.3 V vs. Mg2+/Mg with the valence change from Mn(III) to Mn(II) in MgMn2O4, being comparable to the ab initio calculation.	Magnesium	71-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-67
27980965-2	2015	For example, by utilizing the valence change from Co(III) to Co(II) in MgCo2O4, Mg insertion occurs at a considerably high potential of about 2.9 V vs. Mg2+/Mg, and similarly it occurs around 2.3 V vs. Mg2+/Mg with the valence change from Mn(III) to Mn(II) in MgMn2O4, being comparable to the ab initio calculation.	Magnesium	80-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-67
27980965-2	2015	For example, by utilizing the valence change from Co(III) to Co(II) in MgCo2O4, Mg insertion occurs at a considerably high potential of about 2.9 V vs. Mg2+/Mg, and similarly it occurs around 2.3 V vs. Mg2+/Mg with the valence change from Mn(III) to Mn(II) in MgMn2O4, being comparable to the ab initio calculation.	Magnesium	80-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-67
27980965-2	2015	For example, by utilizing the valence change from Co(III) to Co(II) in MgCo2O4, Mg insertion occurs at a considerably high potential of about 2.9 V vs. Mg2+/Mg, and similarly it occurs around 2.3 V vs. Mg2+/Mg with the valence change from Mn(III) to Mn(II) in MgMn2O4, being comparable to the ab initio calculation.	Manganese(2+)	250-256	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-67
27980965-2	2015	For example, by utilizing the valence change from Co(III) to Co(II) in MgCo2O4, Mg insertion occurs at a considerably high potential of about 2.9 V vs. Mg2+/Mg, and similarly it occurs around 2.3 V vs. Mg2+/Mg with the valence change from Mn(III) to Mn(II) in MgMn2O4, being comparable to the ab initio calculation.	mgmn2o4	260-267	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-67
26039085-0	2015	Suppressing of slow magnetic relaxation in tetracoordinate Co(II) field-induced single-molecule magnet in hybrid material with ferromagnetic barium ferrite.	barium ferrite	141-155	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
25917121-3	2015	The mechanism of mediated oxygen reduction by single VB12 droplets is revealed as via both Co(II) and Co(I) reduced from Co(III) in VB12 through one or two electron transfer followed by the four-electron reduction of oxygen.	Oxygen	26-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-97
25917121-3	2015	The mechanism of mediated oxygen reduction by single VB12 droplets is revealed as via both Co(II) and Co(I) reduced from Co(III) in VB12 through one or two electron transfer followed by the four-electron reduction of oxygen.	Oxygen	217-223	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-97
25946982-0	2015	Enhancing the ferromagnetic coupling in extended phloroglucinol complexes by increasing the metal SOMO-ligand overlap: synthesis and characterization of a trinuclear Co(II)(3) triplesalophen complex.	Phloroglucinol	49-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	166-172
25946982-1	2015	The triplesalophen complex [(baron(Me))Co(II)(3)] has been synthesized and characterized.	triplesalophen	4-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-45
25446850-9	2015	Among genes involved in PGF2alpha biosynthesis, metabolism and action PLA2G2A, PTGS2/COX-2, ABCC4 and PTGFR were up-regulated, mRNA levels of SLCO2A, PTGDS and HPGDS were unchanged, and genes PLA2G4A and HPGD were down-regulated in diseased tissue.	Dinoprost	24-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-90
25797286-9	2015	The expression of COX-2 and iNOS was also inhibited by taraxasterol.	taraxasterol	55-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-23
25909690-0	2015	Diaryl-Substituted (Dihydro)pyrrolo[3,2,1-hi]indoles, a Class of Potent COX-2 Inhibitors with Tricyclic Core Structure.	diaryl-substituted (dihydro)pyrrolo[3,2,1-hi]indoles	0-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
26053397-3	2015	We describe the exact mechanism of the effect of vanadium compounds on protein tyrosine phosphatases (PTP), epidermal growth factor receptor (EGFR), PLCgamma, Src, mitogen-activated protein kinase (MAPK) cascades, transcription factor NF-kappaB, the effect on the proteolysis of COX-2 and the activity of cPLA2.	Vanadium	49-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	279-284
25959673-0	2015	Cooperation between COA6 and SCO2 in COX2 maturation during cytochrome c oxidase assembly links two mitochondrial cardiomyopathies.	sco2	29-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-41
25959673-2	2015	COX1 and COX2 contain heme and copper redox centers, which are integrated during assembly of the enzyme.	Heme	22-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	9-13
25959673-2	2015	COX1 and COX2 contain heme and copper redox centers, which are integrated during assembly of the enzyme.	Copper	31-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	9-13
25959673-6	2015	COA6 interacts transiently with the copper-containing catalytic domain of newly synthesized COX2.	Copper	36-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-96
25959673-9	2015	Our analyses define COA6 as a constituent of the mitochondrial copper relay system, linking defects in COX2 metallation to cardiac cytochrome c oxidase deficiency.	Copper	63-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-107
26039085-1	2015	The novel field-induced single-molecule magnet based on a tetracoordinate mononuclear heteroleptic Co(II) complex involving two heterocyclic benzimidazole (bzi) and two thiocyanido ligands, [Co(bzi)2(NSC)2], (CoL4), was prepared and thoroughly characterized.	benzimidazole	141-154	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-105
26039085-1	2015	The novel field-induced single-molecule magnet based on a tetracoordinate mononuclear heteroleptic Co(II) complex involving two heterocyclic benzimidazole (bzi) and two thiocyanido ligands, [Co(bzi)2(NSC)2], (CoL4), was prepared and thoroughly characterized.	benzimidazole	156-159	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-105
26039085-1	2015	The novel field-induced single-molecule magnet based on a tetracoordinate mononuclear heteroleptic Co(II) complex involving two heterocyclic benzimidazole (bzi) and two thiocyanido ligands, [Co(bzi)2(NSC)2], (CoL4), was prepared and thoroughly characterized.	co(bzi)	191-198	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-105
25645360-6	2015	PGE2 and TXB2 production is not altered by all tested Cd concentrations; however, the significant stimulation of PGE2 and TXB2 production is observed when macrophages are exposed to both cadmium and COX-2 selective inhibitor, NS-398.	Dinoprostone	0-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	199-204
26139944-0	2015	Room Temperature Activation of Aryloxysulfonyl Azides by [Co(II)(TPP)] for Selective Radical Aziridination of Alkenes via Metalloradical Catalysis.	aryloxysulfonyl azides	31-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
26139944-0	2015	Room Temperature Activation of Aryloxysulfonyl Azides by [Co(II)(TPP)] for Selective Radical Aziridination of Alkenes via Metalloradical Catalysis.	Alkenes	110-117	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
26139944-3	2015	In addition to generating the environmentally benign N2 as the only byproduct, this Co(II)-based metalloradical aziridination process features mild reaction conditions and operational simplicity.	Nitrogen	53-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-89
25645360-0	2015	The Effect of Cadmium on COX-1 and COX-2 Gene, Protein Expression, and Enzymatic Activity in THP-1 Macrophages.	Cadmium	14-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40
25645360-6	2015	PGE2 and TXB2 production is not altered by all tested Cd concentrations; however, the significant stimulation of PGE2 and TXB2 production is observed when macrophages are exposed to both cadmium and COX-2 selective inhibitor, NS-398.	Dinoprostone	113-117	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	199-204
25645360-1	2015	The aim of this study was to examine the effects of cadmium in concentrations relevant to those detected in human serum on cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) expression at mRNA, protein, and enzyme activity levels in THP-1 macrophages.	Cadmium	52-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	170-175
25645360-6	2015	PGE2 and TXB2 production is not altered by all tested Cd concentrations; however, the significant stimulation of PGE2 and TXB2 production is observed when macrophages are exposed to both cadmium and COX-2 selective inhibitor, NS-398.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	226-232	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	199-204
25645360-5	2015	Our study demonstrates that cadmium at the highest tested concentrations modulates COX-1 and COX-2 at mRNA level in THP-1 macrophages; however, the lower tested cadmium concentrations appear to inhibit COX-1 protein expression.	Cadmium	28-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-98
25996641-0	2015	Phloretin inhibits interleukin-1beta-induced COX-2 and ICAM-1 expression through inhibition of MAPK, Akt, and NF-kappaB signaling in human lung epithelial cells.	Phloretin	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-50
25996641-4	2015	Phloretin inhibited levels of prostaglandin E2, decreased COX-2 expression, and suppressed IL-8, monocyte chemotactic protein 1, and IL-6 production.	Phloretin	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
25996641-7	2015	In addition, ICAM-1 and COX-2 expression was suppressed by pretreatment with both MAPK inhibitors and phloretin in inflammatory A549 cells.	Phloretin	102-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
25996641-9	2015	These results suggest that phloretin might have an anti-inflammatory effect by inhibiting proinflammatory cytokine, COX-2, and ICAM-1 expression via blocked NF-kappaB and MAPK signaling pathways.	Phloretin	27-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-121
25970648-10	2015	These potentials are shifted to significantly higher potentials (by ~0.45 V) than the literature values for the corresponding Fe(II) and Co(II) complexes of the equivalent all-pyridine ligand, consistent with replacement of the two pyridine rings by two pyrazine rings significantly stabilizing the lower oxidation states.	pyridine	176-184	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-143
25970648-10	2015	These potentials are shifted to significantly higher potentials (by ~0.45 V) than the literature values for the corresponding Fe(II) and Co(II) complexes of the equivalent all-pyridine ligand, consistent with replacement of the two pyridine rings by two pyrazine rings significantly stabilizing the lower oxidation states.	pyridine	232-240	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-143
25974728-3	2015	In contrast, absorption of methanol and ethanol by 2 at 295 K led to structural transformation probably connected with coordination of these alcohols to Co(II).	Methanol	27-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	153-159
25970648-10	2015	These potentials are shifted to significantly higher potentials (by ~0.45 V) than the literature values for the corresponding Fe(II) and Co(II) complexes of the equivalent all-pyridine ligand, consistent with replacement of the two pyridine rings by two pyrazine rings significantly stabilizing the lower oxidation states.	Pyrazines	254-262	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-143
25974728-3	2015	In contrast, absorption of methanol and ethanol by 2 at 295 K led to structural transformation probably connected with coordination of these alcohols to Co(II).	Ethanol	28-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	153-159
25974728-3	2015	In contrast, absorption of methanol and ethanol by 2 at 295 K led to structural transformation probably connected with coordination of these alcohols to Co(II).	Alcohols	141-149	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	153-159
25974728-0	2015	Solvent-Induced Change of Electronic Spectra and Magnetic Susceptibility of Co(II) Coordination Polymer with 2,4,6-Tris(4-pyridyl)-1,3,5-triazine.	2,4,6-Tri(4-pyridyl)-1,3,5-triazine	109-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-81
25691007-4	2015	The MDR phenotype is associated with the constitutive expression of COX-2 and iNOS, whereas celecoxib, a specific inhibitor of COX-2 activity, reverses drug resistance of MDR cells by releasing cytochrome c from mitochondria.	Celecoxib	92-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	127-132
25691007-8	2015	Low and moderate concentrations of celecoxib modulate the expression of iNOS and P-gp in mitochondria of MDR cancer cells independently from inhibition of COX-2 activity.	Celecoxib	35-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	155-160
26028848-12	2015	An enhancement of phagocytic cells was observed following the pre exposure of cells to 1 muM dexamethasone, a glucocorticoids, In this study, histologic evidence is presented which supports the finding that COX-2 expression is upregulated in OSF specimens compared to normal oral submucosal cells.	Dexamethasone	93-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	207-212
25841193-1	2015	New carbonaceous materials were obtained using a fast aqueous solution combustion process from mixtures of exhausted coffee, ammonium nitrate (oxidizer) and urea (fuel) heated at 600, 700, 800 or 900  C. The resulting powders were effective adsorbents for removing Co(II) and Cd(II) from aqueous solutions.	carbonaceous	4-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	265-271
26028848-13	2015	Strong immunostaining for COX-2 was detected in arecoline exposed NOMC and cells from OSF patient.	Arecoline	48-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-31
25898179-9	2015	Pharmacological targeting of cyclooxygenase-1 and -2 (COX-1 and -2) using the nonselective inhibitor indomethacin, COX-1 inhibitor SC-560, and COX-2 inhibitor celecoxib revealed a contribution of COX-2 activity to the NMDA receptor"s downstream signaling events affecting BCRP.	Celecoxib	159-168	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	143-148
25672286-7	2015	Furthermore, the expression levels of chemokine (C-C motif) ligand (CCL)2, cyclooxygenase (COX)-2 and prostaglandin E2 (PGE2) were increased in the Transwell system and the inhibition of COX-2, but not CCL2, significantly decreased the polarization of the M2 macrophages.	Dinoprostone	102-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	187-192
25672286-7	2015	Furthermore, the expression levels of chemokine (C-C motif) ligand (CCL)2, cyclooxygenase (COX)-2 and prostaglandin E2 (PGE2) were increased in the Transwell system and the inhibition of COX-2, but not CCL2, significantly decreased the polarization of the M2 macrophages.	Dinoprostone	120-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	187-192
25672286-8	2015	In addition, mechanistic analysis revealed the importance of the COX-2/PGE2 pathway in OCSCs to activate Janus kinase (JAK) signaling in macrophages to elicit M2 polarization.	Dinoprostone	71-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-70
25845399-4	2015	We found that the proliferation of PC3 cells, as determined using the MTT assay, and the expression of cyclin D1, COX-2, Bcl-2 and survivin proteins elevated by LPS were distinctly inhibited by sesamin in a dose-dependent manner.	sesamin	194-201	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-119
25724470-8	2015	Nimesulide also induced apoptosis, which was accompanied by a significant decrease in the expression of COX-2 and survivin and an increase in caspase-3 expression.	nimesulide	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
25724470-9	2015	Nimesulide downregulated the phosphorylation levels of JAK2 and STAT3, and JAK2 inhibition by AG490 significantly augmented both nimesulide-induced apoptosis and the downregulation of COX-2 and survivin (P&lt;0.05).	nimesulide	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	184-189
25724470-11	2015	Thus, nimesulide downregulates COX-2 and survivin expression and upregulates caspase-3 expression in Eca-109 cells, by inactivating the JAK2/STAT3 pathway.	nimesulide	6-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-36
25933977-10	2015	Moreover, compared to AA and AA+LPS groups, cells incubated with EPA, DHA, EPA+LPS and DHA+LPS showed decreased expression of COX-2, cPGES and FP-receptor.	dehydroacetic acid	70-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-131
25933977-10	2015	Moreover, compared to AA and AA+LPS groups, cells incubated with EPA, DHA, EPA+LPS and DHA+LPS showed decreased expression of COX-2, cPGES and FP-receptor.	dehydroacetic acid	87-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-131
26034355-4	2015	The expression of COX-2 and HER-2 were detected by immunohistochemistry using the streptavidin-biotin-peroxidase method.	Biotin	95-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-23
25881506-5	2015	NS398, a selective COX-2 inhibitor, reduced nitrite levels.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	0-5	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-24
25881506-5	2015	NS398, a selective COX-2 inhibitor, reduced nitrite levels.	Nitrites	44-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-24
25924972-1	2015	An electrocatalytic material for the H2 evolution reaction (HER) in acidic aqueous solution has been prepared by electropolymerization of Co(ii) dibenzotetraaza[14] annulene (CoTAA).	Hydrogen	37-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	138-144
25907670-3	2015	Owing to the different orientations of the carboxylate groups, the benzenedicarboxylates adopt various bridging modes to connect the Co(II) ions into a series of 1D carboxylate cobalt architectures based on the 1D chain, binuclear and single-ion magnetic units, respectively.	carboxylate	43-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	133-139
25882594-5	2015	Thus, at 300  C, Co(II)-azide units in the SBU of Co-MFU-4l are converted into Co(II)-isocyanate under continuous CO gas flow, involving the formation of a nitrene intermediate.	phenylnitrene	156-163	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22
25882594-5	2015	Thus, at 300  C, Co(II)-azide units in the SBU of Co-MFU-4l are converted into Co(II)-isocyanate under continuous CO gas flow, involving the formation of a nitrene intermediate.	phenylnitrene	156-163	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-84
25907670-3	2015	Owing to the different orientations of the carboxylate groups, the benzenedicarboxylates adopt various bridging modes to connect the Co(II) ions into a series of 1D carboxylate cobalt architectures based on the 1D chain, binuclear and single-ion magnetic units, respectively.	carboxylate	76-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	133-139
25907670-3	2015	Owing to the different orientations of the carboxylate groups, the benzenedicarboxylates adopt various bridging modes to connect the Co(II) ions into a series of 1D carboxylate cobalt architectures based on the 1D chain, binuclear and single-ion magnetic units, respectively.	Cobalt	177-183	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	133-139
25891820-0	2015	Plausible mechanisms of the fenton-like reactions, M = Fe(II) and Co(II), in the presence of RCO2(-) substrates: are OH( ) radicals formed in the process?	rco2	93-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-72
25868745-7	2015	Some compounds with significant analgesic and/or anti-inflammatory activities as well as low ulcer scores were further evaluated for in vitro COX-1 and COX-2 inhibitory potential in a COX-catalyzed prostaglandin biosynthesis assay.	Prostaglandins	198-211	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-157
25706679-2	2015	The synthesized Schiff bases were used for complexation with different metal ions like Co(II), Ni(II) and Cu(II) by using a molar ratio of ligand: metal as 2:1.	Schiff Bases	16-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-93
25706679-2	2015	The synthesized Schiff bases were used for complexation with different metal ions like Co(II), Ni(II) and Cu(II) by using a molar ratio of ligand: metal as 2:1.	Metals	71-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-93
25706679-2	2015	The synthesized Schiff bases were used for complexation with different metal ions like Co(II), Ni(II) and Cu(II) by using a molar ratio of ligand: metal as 2:1.	Metals	147-152	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-93
25891820-1	2015	DFT calculations concerning the plausible mechanism of Fenton-like reactions catalyzed by Fe(II) and Co(II) cations in the presence of carboxylate ligands suggest that hydroxyl radicals are not formed in these reactions.	carboxylate	135-146	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-107
25891820-1	2015	DFT calculations concerning the plausible mechanism of Fenton-like reactions catalyzed by Fe(II) and Co(II) cations in the presence of carboxylate ligands suggest that hydroxyl radicals are not formed in these reactions.	Hydroxyl Radical	168-185	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-107
25946000-10	2015	Among the 9 drugs, 4 drugs (diflunisal, nabumetone, niflumic acid and valdecoxib) targeting COX2 (prostaglandin G/H synthase 2) were repurposed for treating type 1 diabetes, and 2 drugs (phenoxybenzamine and idazoxan) targeting ADRA2A (Alpha-2A adrenergic receptor) had a new indication for treating type 2 diabetes.	Diflunisal	28-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-96
25946000-10	2015	Among the 9 drugs, 4 drugs (diflunisal, nabumetone, niflumic acid and valdecoxib) targeting COX2 (prostaglandin G/H synthase 2) were repurposed for treating type 1 diabetes, and 2 drugs (phenoxybenzamine and idazoxan) targeting ADRA2A (Alpha-2A adrenergic receptor) had a new indication for treating type 2 diabetes.	Nabumetone	40-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-96
25946000-10	2015	Among the 9 drugs, 4 drugs (diflunisal, nabumetone, niflumic acid and valdecoxib) targeting COX2 (prostaglandin G/H synthase 2) were repurposed for treating type 1 diabetes, and 2 drugs (phenoxybenzamine and idazoxan) targeting ADRA2A (Alpha-2A adrenergic receptor) had a new indication for treating type 2 diabetes.	Niflumic Acid	52-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-96
25946000-10	2015	Among the 9 drugs, 4 drugs (diflunisal, nabumetone, niflumic acid and valdecoxib) targeting COX2 (prostaglandin G/H synthase 2) were repurposed for treating type 1 diabetes, and 2 drugs (phenoxybenzamine and idazoxan) targeting ADRA2A (Alpha-2A adrenergic receptor) had a new indication for treating type 2 diabetes.	valdecoxib	70-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-96
25946000-10	2015	Among the 9 drugs, 4 drugs (diflunisal, nabumetone, niflumic acid and valdecoxib) targeting COX2 (prostaglandin G/H synthase 2) were repurposed for treating type 1 diabetes, and 2 drugs (phenoxybenzamine and idazoxan) targeting ADRA2A (Alpha-2A adrenergic receptor) had a new indication for treating type 2 diabetes.	Phenoxybenzamine	187-203	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-96
25946000-10	2015	Among the 9 drugs, 4 drugs (diflunisal, nabumetone, niflumic acid and valdecoxib) targeting COX2 (prostaglandin G/H synthase 2) were repurposed for treating type 1 diabetes, and 2 drugs (phenoxybenzamine and idazoxan) targeting ADRA2A (Alpha-2A adrenergic receptor) had a new indication for treating type 2 diabetes.	Idazoxan	208-216	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-96
25770423-4	2015	In this study, we showed that COX-2 selective inhibitor celecoxib enhanced the radiation-induced inhibition of cell proliferation and apoptosis in HeLa and SACC-83 cells.	Celecoxib	56-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-35
25770423-7	2015	However, treatment with celecoxib or another COX-2 selective inhibitor (valdecoxib) completely blocked radiation-induced increase of PTEN phosphorylation, rescued radiation-induced decrease in PTEN membrane translocation, and correspondingly inactivated AKT.	valdecoxib	72-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-50
25661191-7	2015	A potential action of 7,8-DHF on cell energy homeostasis was corroborated by the normalization in levels of PGC-1alpha, TFAM, COII, AMPK and SIRT1 in animals subjected to TBI.	6,7-dihydroxyflavone	22-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-130
25866240-0	2015	Design, synthesis, biological evaluation and molecular modeling of dihydropyrazole sulfonamide derivatives as potential COX-1/COX-2 inhibitors.	dihydropyrazole sulfonamide	67-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-131
25866240-1	2015	Novel dihydropyrazole sulfonamide derivatives (30-56) were designed, synthesized, and evaluated for their biological activities as COX-1 and COX-2 inhibitors.	dihydropyrazole sulfonamide	6-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	141-146
25866240-3	2015	Among the compounds, compound 48 exhibited the most potent and selective COX-2 inhibitor (COX-2 IC50=0.33 muM; COX-1 IC50=68.49 muM) relative to the reference drugs celecoxib (IC50=0.052 muM).	Celecoxib	165-174	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-78
25422106-4	2015	Our results show that constitutive expression of human COX-2 (hCOX-2) in hepatocytes protects against adiposity, inflammation, and, hence, insulin resistance induced by a high-fat diet, as demonstrated by decreased hepatic steatosis, adiposity, plasmatic and hepatic triglycerides and free fatty acids, increased adiponectin-to-leptin ratio, and decreased levels of proinflammatory cytokines, together with an enhancement of insulin sensitivity and glucose tolerance.	Triglycerides	267-280	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-60
25422106-4	2015	Our results show that constitutive expression of human COX-2 (hCOX-2) in hepatocytes protects against adiposity, inflammation, and, hence, insulin resistance induced by a high-fat diet, as demonstrated by decreased hepatic steatosis, adiposity, plasmatic and hepatic triglycerides and free fatty acids, increased adiponectin-to-leptin ratio, and decreased levels of proinflammatory cytokines, together with an enhancement of insulin sensitivity and glucose tolerance.	Triglycerides	267-280	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-68
25422106-4	2015	Our results show that constitutive expression of human COX-2 (hCOX-2) in hepatocytes protects against adiposity, inflammation, and, hence, insulin resistance induced by a high-fat diet, as demonstrated by decreased hepatic steatosis, adiposity, plasmatic and hepatic triglycerides and free fatty acids, increased adiponectin-to-leptin ratio, and decreased levels of proinflammatory cytokines, together with an enhancement of insulin sensitivity and glucose tolerance.	Fatty Acids, Nonesterified	285-301	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-60
25422106-4	2015	Our results show that constitutive expression of human COX-2 (hCOX-2) in hepatocytes protects against adiposity, inflammation, and, hence, insulin resistance induced by a high-fat diet, as demonstrated by decreased hepatic steatosis, adiposity, plasmatic and hepatic triglycerides and free fatty acids, increased adiponectin-to-leptin ratio, and decreased levels of proinflammatory cytokines, together with an enhancement of insulin sensitivity and glucose tolerance.	Fatty Acids, Nonesterified	285-301	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-68
25422106-4	2015	Our results show that constitutive expression of human COX-2 (hCOX-2) in hepatocytes protects against adiposity, inflammation, and, hence, insulin resistance induced by a high-fat diet, as demonstrated by decreased hepatic steatosis, adiposity, plasmatic and hepatic triglycerides and free fatty acids, increased adiponectin-to-leptin ratio, and decreased levels of proinflammatory cytokines, together with an enhancement of insulin sensitivity and glucose tolerance.	Glucose	449-456	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-60
25422106-4	2015	Our results show that constitutive expression of human COX-2 (hCOX-2) in hepatocytes protects against adiposity, inflammation, and, hence, insulin resistance induced by a high-fat diet, as demonstrated by decreased hepatic steatosis, adiposity, plasmatic and hepatic triglycerides and free fatty acids, increased adiponectin-to-leptin ratio, and decreased levels of proinflammatory cytokines, together with an enhancement of insulin sensitivity and glucose tolerance.	Glucose	449-456	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-68
25422106-5	2015	Furthermore, hCOX-2 transgenic mice exhibited increased whole-body energy expenditure due in part by induction of thermogenesis and fatty acid oxidation.	Fatty Acids	132-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-19
25666316-2	2015	PGE2 levels are regulated not only by cyclooxygenases (COX-1 and COX-2) but also by 15-hydroxyprostaglandin dehydrogenase (15-PGDH), the major PGE2-degrading enzyme.	Dinoprostone	0-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-70
25666316-10	2015	CONCLUSIONS: Our study for the first time demonstrated differential expression of the PGE2-related enzymes COX-2 and 15-PGDH in colonic mucosa from UC, CD, and acute DD.	Dinoprostone	86-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-112
25732618-6	2015	A good recovery of silver (40-65%) was also obtained in the presence of Cd(II), Co(II), Cr(VI), Ni(II), and As(V) at lower or equivalent concentrations with Ag(I), either from individually added metals or from all metal ions mixed together.	Silver	19-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-86
25738635-10	2015	Treatment of PLC/PRF/5 hepatoma cells with 500 micromol/l NaHS (a donor of H2S) for 24 h markedly increased the expression levels of CSE, CBS, p-IkappaB and NF-kappaB activation, leading to COX-2 and MMP-2 overexpression, and decreased caspase-3 production, as well as increased cell viability and decreased number of apoptotic cells.	sodium bisulfide	58-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	190-195
25738635-10	2015	Treatment of PLC/PRF/5 hepatoma cells with 500 micromol/l NaHS (a donor of H2S) for 24 h markedly increased the expression levels of CSE, CBS, p-IkappaB and NF-kappaB activation, leading to COX-2 and MMP-2 overexpression, and decreased caspase-3 production, as well as increased cell viability and decreased number of apoptotic cells.	Hydrogen Sulfide	75-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	190-195
25691529-7	2015	Furthermore, in a mutant deleted of the Zn(II) exporter ZntA, they also trigger the expression of their target genes in response to either Zn(II), Cd(II), Pb(II), or Co(II).	Zinc	40-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	166-172
25691529-7	2015	Furthermore, in a mutant deleted of the Zn(II) exporter ZntA, they also trigger the expression of their target genes in response to either Zn(II), Cd(II), Pb(II), or Co(II).	znta	56-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	166-172
25988363-2	2015	In this study, we found that a majority of the product from the cells co-expressing human COX-2, mPGES-1, and PGIS was PGE2.	Dinoprostone	119-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-95
25988363-6	2015	When COX-2-10aa-PGIS (with a 14.4 A separation) was co-expressed with mPGES-1 on the ER membrane, a major product was PGE2, but not PGI2.	Dinoprostone	118-122	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	5-10
25988363-7	2015	However, expression of COX-2-10aa-PGIS and mPGES-1 on a separated ER with a distance of &gt;&gt;30.8 A reduced the level of PGE2 production.	Dinoprostone	124-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-28
25303541-5	2015	The effects of celecoxib were COX2 independent.	Celecoxib	15-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-34
25804832-5	2015	It was found that fluorescence intensity of the modified CdS QDs quenched selectively by addition of Co(II) ion in comparison with other cations tested.	Cadmium	57-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-107
25804832-6	2015	The ligand capped CdS QDs can be used as a fluorescent bulk chemosensor for detection of Co(II) ions.	Cadmium	18-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-95
25804832-9	2015	The nanosensor exhibits high selectivity toward Co(II) ions in comparison with common metal ions.	Metals	86-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-54
25891820-0	2015	Plausible mechanisms of the fenton-like reactions, M = Fe(II) and Co(II), in the presence of RCO2(-) substrates: are OH( ) radicals formed in the process?	oh( ) radicals	117-131	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-72
25812605-9	2015	Cells treated with TMP exhibited significantly attenuated GSK-3beta, NF-kappaB (p65) and c-myc expression, followed by downregulation of bcl-2, cox-2 and survivin and an upregulation of p27.	tetramethylpyrazine	19-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	144-149
25886460-9	2015	In contrast, 5-FU enhanced formation of PGE2, LTB4 and mPGES expression, but suppressed LXA4 synthesis and COX-2 expression.	Fluorouracil	13-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-112
25638779-3	2015	Aspirin (acetylsalicylate, ASA) inhibits AA oxidation by cyclooxygenase (COX)-1 and COX-2.	Aspirin	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-89
25638779-3	2015	Aspirin (acetylsalicylate, ASA) inhibits AA oxidation by cyclooxygenase (COX)-1 and COX-2.	Aspirin	9-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-89
25638779-3	2015	Aspirin (acetylsalicylate, ASA) inhibits AA oxidation by cyclooxygenase (COX)-1 and COX-2.	Aspirin	27-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-89
26137580-0	2015	COX-2 and EGFR: Partners in Crime Split by Aspirin.	Aspirin	43-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
25898207-10	2015	Pretreatment with NS398 (a COX-2 inhibitor) to inhibit prostaglandin E2 (PGE2) production reversed the induction of cleaved caspase-3, cleaved PARP, and MS1 cell viability.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	18-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-32
25898207-10	2015	Pretreatment with NS398 (a COX-2 inhibitor) to inhibit prostaglandin E2 (PGE2) production reversed the induction of cleaved caspase-3, cleaved PARP, and MS1 cell viability.	Dinoprostone	55-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-32
25898207-10	2015	Pretreatment with NS398 (a COX-2 inhibitor) to inhibit prostaglandin E2 (PGE2) production reversed the induction of cleaved caspase-3, cleaved PARP, and MS1 cell viability.	Dinoprostone	73-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-32
25839944-7	2015	Collectively, our results indicate that a reduction in the basicity of the lower axial ligand causes changes to the cofactor"s electronic structure in the Co(II) state that replicate the effects seen upon binding of Co(II)Cbl to Class I isomerases, which replace the lower axial dimethylbenzimidazole ligand of AdoCbl with a protein-derived histidine (His) residue.	Cobalt(2+)	216-222	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	155-161
25839944-7	2015	Collectively, our results indicate that a reduction in the basicity of the lower axial ligand causes changes to the cofactor"s electronic structure in the Co(II) state that replicate the effects seen upon binding of Co(II)Cbl to Class I isomerases, which replace the lower axial dimethylbenzimidazole ligand of AdoCbl with a protein-derived histidine (His) residue.	5,6-dimethylbenzimidazole	279-300	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	155-161
25839944-7	2015	Collectively, our results indicate that a reduction in the basicity of the lower axial ligand causes changes to the cofactor"s electronic structure in the Co(II) state that replicate the effects seen upon binding of Co(II)Cbl to Class I isomerases, which replace the lower axial dimethylbenzimidazole ligand of AdoCbl with a protein-derived histidine (His) residue.	Histidine	341-350	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	155-161
25839944-7	2015	Collectively, our results indicate that a reduction in the basicity of the lower axial ligand causes changes to the cofactor"s electronic structure in the Co(II) state that replicate the effects seen upon binding of Co(II)Cbl to Class I isomerases, which replace the lower axial dimethylbenzimidazole ligand of AdoCbl with a protein-derived histidine (His) residue.	Histidine	352-355	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	155-161
25886460-11	2015	All the PUFAs tested enhanced, while 5-FU decreased LXA4 formation in RKO cells; whereas GLA, AA, and 5-FU augmented while LA, ALA, EPA and DHA enhanced COX-2 expression in RKO cells.	Alanine	127-130	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	153-158
25886460-11	2015	All the PUFAs tested enhanced, while 5-FU decreased LXA4 formation in RKO cells; whereas GLA, AA, and 5-FU augmented while LA, ALA, EPA and DHA enhanced COX-2 expression in RKO cells.	dehydroacetic acid	140-143	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	153-158
25854540-11	2015	Most of these transformations proceed through low-valent cobalt complexes, which are conveniently generated in situ from air-stable Co(II) salts by Zn- or Mn-mediated reduction.	Cobalt	57-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-138
25854540-11	2015	Most of these transformations proceed through low-valent cobalt complexes, which are conveniently generated in situ from air-stable Co(II) salts by Zn- or Mn-mediated reduction.	Zinc	148-150	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-138
25760669-1	2015	Nine new coordination compounds have been synthesized by the reaction of salts of bivalent metal ions (a=Zn(II) , b=Cu(II) , c=Ni(II) , d=Co(II) ) with the bis(benzoylhydrazone) derivative of 4,6-diacetylresorcinol (H4 L).	bis(benzoylhydrazone)	156-177	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	138-144
25760981-10	2015	(-) from a carbon atom not involved in the pi conjugation system of the corrin occurs in the first step, resulting in formation of a Co(III) C-centered radical that undergoes rapid intramolecular electron transfer to form the corresponding Co(II) carbocation complex for about 50 % of these complexes.	Carbon	11-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	133-138
25760981-10	2015	(-) from a carbon atom not involved in the pi conjugation system of the corrin occurs in the first step, resulting in formation of a Co(III) C-centered radical that undergoes rapid intramolecular electron transfer to form the corresponding Co(II) carbocation complex for about 50 % of these complexes.	corrin	72-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	133-138
26131080-5	2015	And several genes related to tumor growth and metastasis including COX2, HIF-1alpha, VEGF-A, COMP, MMP-1, MMP-9, SCP2, SDC3, which were down-regulated by DHA, were further confirmed in HCT-15 cell line using RT-PCR method.	Docosahexaenoic Acids	154-157	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-71
25945055-0	2015	Artesunate inhibits the growth and induces apoptosis of human gastric cancer cells by downregulating COX-2.	Artesunate	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-106
25945055-6	2015	Artesunate markedly inhibited gastric cancer cell proliferation in a time- and dose-dependent manner and induced apoptosis in gastric cancer cells a dose-dependent manner, which was associated with a reduction in COX-2 expression.	Artesunate	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	213-218
25945055-7	2015	Treatment with the selective COX-2 inhibitor celecoxib, or transient transfection of gastric cancer cells with COX-2 siRNA, also inhibited cell proliferation and induced apoptosis.	Celecoxib	45-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34
25945055-11	2015	One of the antitumor mechanisms of artesunate may be that its inhibition of COX-2 led to reduced proliferation and induction of apoptosis, connected with mitochondrial dysfunction.	Artesunate	35-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-81
25798900-4	2015	A paramagnetic S = 3/2 impurity that forms during the synthesis of [Co(II)(dmgH)2P(nBu)3] when exposed to adventitious oxygen has also been characterized.	2p	80-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-74
25798900-4	2015	A paramagnetic S = 3/2 impurity that forms during the synthesis of [Co(II)(dmgH)2P(nBu)3] when exposed to adventitious oxygen has also been characterized.	Oxygen	119-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-74
25659740-0	2015	DNA binding, photoactivated DNA cleavage and cytotoxic activity of Cu(II) and Co(II) based Schiff-base azo photosensitizers.	Schiff Bases	91-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-84
25666328-3	2015	Metal complexes are like [M(AMTA)2], [M(ATA)2] type, where M=Mn(II), Co(II) and Cu(II).	Metals	0-5	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-75
25659740-0	2015	DNA binding, photoactivated DNA cleavage and cytotoxic activity of Cu(II) and Co(II) based Schiff-base azo photosensitizers.	anthrone	103-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-84
25659740-1	2015	A new class of Cu(II) and Co(II) complexes of azo-containing Schiff base of the type [Cu(L1)2] and [Co(L1)2], where L1=4-[(E)-{2-hydroxy-3-[(E)-(4-bromophenyl)diazenyl]benzylidene}amino]benzoic acid have been synthesized and characterized.	anthrone	46-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-32
25659740-1	2015	A new class of Cu(II) and Co(II) complexes of azo-containing Schiff base of the type [Cu(L1)2] and [Co(L1)2], where L1=4-[(E)-{2-hydroxy-3-[(E)-(4-bromophenyl)diazenyl]benzylidene}amino]benzoic acid have been synthesized and characterized.	Schiff Bases	61-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-32
25659740-4	2015	Furthermore, the Cu(II) and Co(II) complexes showed photocytotoxicity toward two selected tumor cell lines MCF-7 and A549 by 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazoliumbromide (MTT) method, and the Cu(II) complex exhibits higher photocytotoxicity than Co(II) complex against each of the selected cell lines, this result is identical with their DNA binding ability order.	monooxyethylene trimethylolpropane tristearate	186-190	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-34
25659740-4	2015	Furthermore, the Cu(II) and Co(II) complexes showed photocytotoxicity toward two selected tumor cell lines MCF-7 and A549 by 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazoliumbromide (MTT) method, and the Cu(II) complex exhibits higher photocytotoxicity than Co(II) complex against each of the selected cell lines, this result is identical with their DNA binding ability order.	cu(ii)	207-213	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-34
25686861-4	2015	IR spectrum shows that the ligand act in a bidentate manner and coordinates N4 donor groups of the ligands to Ni(II), Cu(II), Co(II) and Zn(II) ions.	Folic Acid	76-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-132
25659740-1	2015	A new class of Cu(II) and Co(II) complexes of azo-containing Schiff base of the type [Cu(L1)2] and [Co(L1)2], where L1=4-[(E)-{2-hydroxy-3-[(E)-(4-bromophenyl)diazenyl]benzylidene}amino]benzoic acid have been synthesized and characterized.	cu(l1)2	86-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-32
25659740-1	2015	A new class of Cu(II) and Co(II) complexes of azo-containing Schiff base of the type [Cu(L1)2] and [Co(L1)2], where L1=4-[(E)-{2-hydroxy-3-[(E)-(4-bromophenyl)diazenyl]benzylidene}amino]benzoic acid have been synthesized and characterized.	co(l1)2	100-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-32
25659740-1	2015	A new class of Cu(II) and Co(II) complexes of azo-containing Schiff base of the type [Cu(L1)2] and [Co(L1)2], where L1=4-[(E)-{2-hydroxy-3-[(E)-(4-bromophenyl)diazenyl]benzylidene}amino]benzoic acid have been synthesized and characterized.	Deferiprone	89-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-32
25659740-1	2015	A new class of Cu(II) and Co(II) complexes of azo-containing Schiff base of the type [Cu(L1)2] and [Co(L1)2], where L1=4-[(E)-{2-hydroxy-3-[(E)-(4-bromophenyl)diazenyl]benzylidene}amino]benzoic acid have been synthesized and characterized.	4-[(e)-{2-hydroxy-3-[(e)-(4-bromophenyl)diazenyl]benzylidene}amino]benzoic acid	119-198	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-32
25686861-4	2015	IR spectrum shows that the ligand act in a bidentate manner and coordinates N4 donor groups of the ligands to Ni(II), Cu(II), Co(II) and Zn(II) ions.	Nickel(2+)	110-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-132
25659740-3	2015	The Cu(II) and Co(II) complexes interacted with CT-DNA via intercalative mode with the respective Kb value of 3.2x10(4) M(-1) and 2.9x10(4) M(-1) and acted as proficient photocleavers of SC pUC19 DNA in UV-A light, forming (1)O2 as the reactive oxygen species with the quantum yield of 0.38 and 0.36, respectively.	Oxygen	226-228	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-21
25686861-5	2015	The detection of H-bonding (OH O) in the [M(LH)2] metal complexes by IR spectra supported the square-planar MN4 coordination of Ni(II), Cu(II) and Co(II) complexes.	oh o	28-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-153
25659740-3	2015	The Cu(II) and Co(II) complexes interacted with CT-DNA via intercalative mode with the respective Kb value of 3.2x10(4) M(-1) and 2.9x10(4) M(-1) and acted as proficient photocleavers of SC pUC19 DNA in UV-A light, forming (1)O2 as the reactive oxygen species with the quantum yield of 0.38 and 0.36, respectively.	Reactive Oxygen Species	236-259	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-21
25686861-5	2015	The detection of H-bonding (OH O) in the [M(LH)2] metal complexes by IR spectra supported the square-planar MN4 coordination of Ni(II), Cu(II) and Co(II) complexes.	(lh)2	43-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-153
25659740-4	2015	Furthermore, the Cu(II) and Co(II) complexes showed photocytotoxicity toward two selected tumor cell lines MCF-7 and A549 by 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazoliumbromide (MTT) method, and the Cu(II) complex exhibits higher photocytotoxicity than Co(II) complex against each of the selected cell lines, this result is identical with their DNA binding ability order.	cu(ii)	17-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	261-267
25659740-4	2015	Furthermore, the Cu(II) and Co(II) complexes showed photocytotoxicity toward two selected tumor cell lines MCF-7 and A549 by 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazoliumbromide (MTT) method, and the Cu(II) complex exhibits higher photocytotoxicity than Co(II) complex against each of the selected cell lines, this result is identical with their DNA binding ability order.	thiazolyl blue	125-184	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-34
25686861-5	2015	The detection of H-bonding (OH O) in the [M(LH)2] metal complexes by IR spectra supported the square-planar MN4 coordination of Ni(II), Cu(II) and Co(II) complexes.	Metals	50-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-153
25686861-5	2015	The detection of H-bonding (OH O) in the [M(LH)2] metal complexes by IR spectra supported the square-planar MN4 coordination of Ni(II), Cu(II) and Co(II) complexes.	Manganese	108-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-153
25686861-5	2015	The detection of H-bonding (OH O) in the [M(LH)2] metal complexes by IR spectra supported the square-planar MN4 coordination of Ni(II), Cu(II) and Co(II) complexes.	Nickel(2+)	128-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-153
25691572-6	2015	We also found that COX2 was highly up-regulated in brain metastatic cells and that COX2-induced prostaglandins were directly able to promote the expression of MMP1 followed by augmenting brain metastasis.	Prostaglandins	96-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-87
26574378-0	2015	1H Chemical Shifts in Paramagnetic Co(II) Pyrazolylborate Complexes: A First-Principles Study.	Hydrogen	0-2	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-41
26574378-0	2015	1H Chemical Shifts in Paramagnetic Co(II) Pyrazolylborate Complexes: A First-Principles Study.	pyrazolylborate	42-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-41
25691572-7	2015	Furthermore, we found that COX2 and prostaglandin were able to activate astrocytes to release chemokine (C-C motif) ligand 7 (CCL7), which in turn promoted self-renewal of tumor-initiating cells in the brain and that knockdown of COX2 significantly reduced the brain metastatic ability of tumor cells.	Prostaglandins	36-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	230-234
25743249-1	2015	A pair of supramolecular isomers of Co(II)-based metal-organic frameworks can be directionally constructed in virtue of solvent templates, which show diverse bilayer networks and lattice packing with the same Co3 SBUs and organic linkers.	Metals	49-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-41
25731596-0	2015	Discrete {Gd(III)4M} (M = Gd(III) or Co(II)) pentanuclear complexes: a new class of metal-organophosphate molecular coolers.	Gadolinium	10-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-43
25731596-0	2015	Discrete {Gd(III)4M} (M = Gd(III) or Co(II)) pentanuclear complexes: a new class of metal-organophosphate molecular coolers.	metal-organophosphate	84-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-43
25743249-1	2015	A pair of supramolecular isomers of Co(II)-based metal-organic frameworks can be directionally constructed in virtue of solvent templates, which show diverse bilayer networks and lattice packing with the same Co3 SBUs and organic linkers.	co3 sbus	209-217	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-41
25643632-4	2015	This conclusion is supported by the fact, that a selective PKC inhibitor, BIM, inhibits ERK1/2 and COX-2 signalings, MEK/ERK1/2 inhibitor, PD98059, nullifies COX-2 signaling, and COX-2 inhibitor, NS-398, attenuates the proliferation and invasiveness potential of the colonic cancer cells.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	139-146	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-104
25643632-4	2015	This conclusion is supported by the fact, that a selective PKC inhibitor, BIM, inhibits ERK1/2 and COX-2 signalings, MEK/ERK1/2 inhibitor, PD98059, nullifies COX-2 signaling, and COX-2 inhibitor, NS-398, attenuates the proliferation and invasiveness potential of the colonic cancer cells.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	139-146	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	158-163
25643632-4	2015	This conclusion is supported by the fact, that a selective PKC inhibitor, BIM, inhibits ERK1/2 and COX-2 signalings, MEK/ERK1/2 inhibitor, PD98059, nullifies COX-2 signaling, and COX-2 inhibitor, NS-398, attenuates the proliferation and invasiveness potential of the colonic cancer cells.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	139-146	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	158-163
24766661-4	2015	alpha-, beta- and delta-CAs use Zn(II) ions at the active site, the gamma-CAs are probably Fe(II) enzymes (but they are active also with bound Zn(II) or Co(II) ions), whereas the zeta-class uses Cd(II) or Zn(II) to perform the physiologic reaction catalysis.	delta-cas	18-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	153-159
25681793-6	2015	Activation of PRR elevated PGE2 release and COX-2 expression in renal inner medullary cells whereas COX-2-derived PGE2via the EP4 receptor mediates the upregulation of PRR during AngII infusion, thus forming a vicious cycle.	pge2via	114-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-105
24946751-9	2015	Treatment with SC-514 reduced the elevated levels of pro-inflammatory cytokines (TNF-alpha and IL-6), iNOS, and COX-2.	SC 514	15-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-117
25892567-10	2015	Delphinidins dose-dependently inhibit NF-kappaB-, activator protein-1- as well as COX-2 expression in UV-exposed epidermis.	delphinidin	0-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
25356658-0	2015	Ethyl acetate extract from Glycosmis parva leaf induces apoptosis and cell-cycle arrest by decreasing expression of COX-2 and altering BCL-2 family gene expression in human colorectal cancer HT-29 cells.	ethyl acetate	0-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-121
25907945-8	2015	CONCLUSION: With a lower efficacy than Sou-Medrol in decreasing postoperative inflammation, celecoxib produces a better effect in inhibiting COX-2 expression, but it does not lower postoperative recurrence rate of rectal cancer.	Celecoxib	92-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	141-146
25806956-0	2015	Correction: olmesartan decreased levels of IL-1beta and TNF-alpha, down-regulated MMP-2, MMP-9, COX-2, RANK/RANKL and up-regulated SOCs-1 in an intestinal mucositis model.	olmesartan	12-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-101
25697075-5	2015	At low temperature, significant antiferromagnetic exchange between magnetic centres is observed for the Co(II) homologue, whereas the magnetic centres are magnetically independent in the Cu(II) derivative, in line with the observed higher clearing temperature in the Co(II) case that testifies of stronger interdisk interactions.	cu(ii)	187-193	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	267-273
25714230-2	2015	In the molecular structures of 1 and 2, the Co(II) ion adopts a distorted tetrahedral coordination geometry, and is coordinated by two nonequivalent bisthienylethene molecules (BrL- in 1, PL- in 2), showing non-photoactive parallel and photoactive antiparallel conformations, respectively.	bisthienylethene	149-165	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-50
25826533-10	2015	In hepatocytes, 2-AG induced the expression of IL-6, -17A, -32 and COX-2, and enhanced activation of hepatic stellate cells (HSC) co-cultivated with PBMC from subjects with CHC.	glyceryl 2-arachidonate	16-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-72
25806762-1	2015	BACKGROUND: The selective cyclooxygenase (COX)-2 inhibitor rofecoxib was withdrawn from the market in 2004 due to cardiovascular toxicity.	rofecoxib	59-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-48
25700155-1	2015	The self-assembly between a water-soluble bis-bidentate ligand L(18w) and Co(II) salts in water affords three high-spin Co(II) products: a dinuclear meso-helicate [Co2(L(18w))3]X4; a tetrahedral cage [Co4(L(18w))6]X8; and a dodecanuclear truncated-tetrahedral cage [Co12(L(18w))18]X24 (X = BF4 or ClO4).	Water	28-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-80
25544494-2	2015	In this study, we investigated the underlying mechanisms and transformation pathways of atrazine degradation by cobalt catalyzed peroxymonosulfate (Co(II)/PMS).	Atrazine	88-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	148-154
25544494-2	2015	In this study, we investigated the underlying mechanisms and transformation pathways of atrazine degradation by cobalt catalyzed peroxymonosulfate (Co(II)/PMS).	Cobalt	112-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	148-154
25544494-2	2015	In this study, we investigated the underlying mechanisms and transformation pathways of atrazine degradation by cobalt catalyzed peroxymonosulfate (Co(II)/PMS).	peroxymonosulfate	129-146	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	148-154
25544494-3	2015	Co(II)/PMS was found to be more efficient for ATZ elimination in aqueous solution than Fe(II)/PMS process.	ammonium ferrous sulfate	87-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
25544494-11	2015	Our results reveal that Co(II)/PMS process might be an efficient technique for remediation of groundwater contaminated by ATZ and structurally related s-triazine herbicides.	Atazanavir Sulfate	122-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-30
25544494-11	2015	Our results reveal that Co(II)/PMS process might be an efficient technique for remediation of groundwater contaminated by ATZ and structurally related s-triazine herbicides.	Triazines	151-161	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-30
25700155-1	2015	The self-assembly between a water-soluble bis-bidentate ligand L(18w) and Co(II) salts in water affords three high-spin Co(II) products: a dinuclear meso-helicate [Co2(L(18w))3]X4; a tetrahedral cage [Co4(L(18w))6]X8; and a dodecanuclear truncated-tetrahedral cage [Co12(L(18w))18]X24 (X = BF4 or ClO4).	Water	28-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-126
25700155-1	2015	The self-assembly between a water-soluble bis-bidentate ligand L(18w) and Co(II) salts in water affords three high-spin Co(II) products: a dinuclear meso-helicate [Co2(L(18w))3]X4; a tetrahedral cage [Co4(L(18w))6]X8; and a dodecanuclear truncated-tetrahedral cage [Co12(L(18w))18]X24 (X = BF4 or ClO4).	Bismuth	42-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-126
25700155-1	2015	The self-assembly between a water-soluble bis-bidentate ligand L(18w) and Co(II) salts in water affords three high-spin Co(II) products: a dinuclear meso-helicate [Co2(L(18w))3]X4; a tetrahedral cage [Co4(L(18w))6]X8; and a dodecanuclear truncated-tetrahedral cage [Co12(L(18w))18]X24 (X = BF4 or ClO4).	bidentate	46-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-126
25700155-1	2015	The self-assembly between a water-soluble bis-bidentate ligand L(18w) and Co(II) salts in water affords three high-spin Co(II) products: a dinuclear meso-helicate [Co2(L(18w))3]X4; a tetrahedral cage [Co4(L(18w))6]X8; and a dodecanuclear truncated-tetrahedral cage [Co12(L(18w))18]X24 (X = BF4 or ClO4).	Water	90-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-80
25700155-1	2015	The self-assembly between a water-soluble bis-bidentate ligand L(18w) and Co(II) salts in water affords three high-spin Co(II) products: a dinuclear meso-helicate [Co2(L(18w))3]X4; a tetrahedral cage [Co4(L(18w))6]X8; and a dodecanuclear truncated-tetrahedral cage [Co12(L(18w))18]X24 (X = BF4 or ClO4).	Water	90-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-126
25700155-1	2015	The self-assembly between a water-soluble bis-bidentate ligand L(18w) and Co(II) salts in water affords three high-spin Co(II) products: a dinuclear meso-helicate [Co2(L(18w))3]X4; a tetrahedral cage [Co4(L(18w))6]X8; and a dodecanuclear truncated-tetrahedral cage [Co12(L(18w))18]X24 (X = BF4 or ClO4).	co12	266-270	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-80
25700155-1	2015	The self-assembly between a water-soluble bis-bidentate ligand L(18w) and Co(II) salts in water affords three high-spin Co(II) products: a dinuclear meso-helicate [Co2(L(18w))3]X4; a tetrahedral cage [Co4(L(18w))6]X8; and a dodecanuclear truncated-tetrahedral cage [Co12(L(18w))18]X24 (X = BF4 or ClO4).	perchlorate	297-301	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-80
25700155-5	2015	The assemblies Co2, Co4, and Co12 are in slow equilibrium (hours/days) in aqueous solution, and this can be conveniently monitored by (1)H NMR spectroscopy because (i) the paramagnetism of Co(II) disperses the signals over a range of ca.	co12	29-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	189-195
25451977-5	2015	Both in human myometrium and amnion, OT-induced activation of the canonical NF-kappaB pathway upregulated key inflammatory labour-associated genes including IL-8, CCL5, IL-6 and COX-2.	Oxytocin	37-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	178-183
25653182-2	2015	Herein, we report a series of 2-D In-Sn-Q compounds prepared using a metal-phenanthroline cationic template, [M(Phen)3](In2Sn2Q8) (amine) nH2O (M = Ni(II), Fe(II) or Co(II); amine = cyclohexylamine (Cha) or 1,6-diaminohexane (Dah); Q = S or Se).	Echothiophate Iodide	30-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	166-172
25653182-2	2015	Herein, we report a series of 2-D In-Sn-Q compounds prepared using a metal-phenanthroline cationic template, [M(Phen)3](In2Sn2Q8) (amine) nH2O (M = Ni(II), Fe(II) or Co(II); amine = cyclohexylamine (Cha) or 1,6-diaminohexane (Dah); Q = S or Se).	-sn-q	36-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	166-172
25653182-2	2015	Herein, we report a series of 2-D In-Sn-Q compounds prepared using a metal-phenanthroline cationic template, [M(Phen)3](In2Sn2Q8) (amine) nH2O (M = Ni(II), Fe(II) or Co(II); amine = cyclohexylamine (Cha) or 1,6-diaminohexane (Dah); Q = S or Se).	Amines	131-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	166-172
25653182-2	2015	Herein, we report a series of 2-D In-Sn-Q compounds prepared using a metal-phenanthroline cationic template, [M(Phen)3](In2Sn2Q8) (amine) nH2O (M = Ni(II), Fe(II) or Co(II); amine = cyclohexylamine (Cha) or 1,6-diaminohexane (Dah); Q = S or Se).	Sulfur	37-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	166-172
25649899-1	2015	Two unprecedented oxonate based 1D coordination polymers with Fe(II) and Co(II) have been synthesized.	Oxonic Acid	18-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-79
25649899-1	2015	Two unprecedented oxonate based 1D coordination polymers with Fe(II) and Co(II) have been synthesized.	Polymers	48-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-79
25617797-6	2015	on COX-2-dependent PGE2 production.	Dinoprostone	19-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	3-8
25774496-10	2015	Inhibition of COX-1 and COX-2 activity significantly diminished NaHS- and L-cysteine-induced protection and hyperemia.	sodium bisulfide	64-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
25774496-10	2015	Inhibition of COX-1 and COX-2 activity significantly diminished NaHS- and L-cysteine-induced protection and hyperemia.	Cysteine	74-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
25774496-11	2015	NaHS increased expression of COX-1, COX-2 mRNAs and proteins and raised CGRP mRNA expression.	sodium bisulfide	0-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-41
25774496-12	2015	These effects of NaHS on COX-1 and COX-2 protein contents were reversed by PAG and capsaicin denervation.	sodium bisulfide	17-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40
25774496-12	2015	These effects of NaHS on COX-1 and COX-2 protein contents were reversed by PAG and capsaicin denervation.	pag	75-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40
25774496-12	2015	These effects of NaHS on COX-1 and COX-2 protein contents were reversed by PAG and capsaicin denervation.	Capsaicin	83-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40
25573411-1	2015	One pot syntheses of furan, thiophene, and pyrrole were accomplished by oxidative deacetylation using Mn(III)/Co(II) catalysts and the Paal-Knorr reaction from 1,5-dicarbonyl compounds, which are prepared from the conjugate addition of ethyl acetoacetate to alpha,beta-unsaturated carbonyl compounds.	furan	21-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-115
25573411-1	2015	One pot syntheses of furan, thiophene, and pyrrole were accomplished by oxidative deacetylation using Mn(III)/Co(II) catalysts and the Paal-Knorr reaction from 1,5-dicarbonyl compounds, which are prepared from the conjugate addition of ethyl acetoacetate to alpha,beta-unsaturated carbonyl compounds.	Thiophenes	28-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-115
25573411-1	2015	One pot syntheses of furan, thiophene, and pyrrole were accomplished by oxidative deacetylation using Mn(III)/Co(II) catalysts and the Paal-Knorr reaction from 1,5-dicarbonyl compounds, which are prepared from the conjugate addition of ethyl acetoacetate to alpha,beta-unsaturated carbonyl compounds.	Pyrroles	43-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-115
25573411-1	2015	One pot syntheses of furan, thiophene, and pyrrole were accomplished by oxidative deacetylation using Mn(III)/Co(II) catalysts and the Paal-Knorr reaction from 1,5-dicarbonyl compounds, which are prepared from the conjugate addition of ethyl acetoacetate to alpha,beta-unsaturated carbonyl compounds.	paal	135-139	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-115
25451977-7	2015	In both gestational tissues, MEK1/2 (U0126; 10 microM) or p38 inhibition (SB203580; 10 microM) suppressed OT-induced COX-2 expression, but OT-induced p65-phosphorylation was only inhibited in amnion, suggesting OT activation of NF-kappaB in amnion is MAPK-dependent.	U 0126	37-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-122
25370832-1	2015	Four novel mononuclear tetrahedral cobalt(II) complexes containing exocyclic mesoionic ligands of molecular formulae [Co(II)(L1)(X)2(MeCN)] X = Cl (1) or Br (2) and [Co(II)(L2)(X)2(MeCN)], X = Cl (3) or Br (4) have been reported.	Cobalt(2+)	35-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-124
25451977-7	2015	In both gestational tissues, MEK1/2 (U0126; 10 microM) or p38 inhibition (SB203580; 10 microM) suppressed OT-induced COX-2 expression, but OT-induced p65-phosphorylation was only inhibited in amnion, suggesting OT activation of NF-kappaB in amnion is MAPK-dependent.	SB 203580	74-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-122
24766418-6	2015	RESULTS: Glutamine reduced LPS-induced iNOS and COX-2 protein expression as well as production of NO and PGE2 in a dose-dependent fashion.	Glutamine	9-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-53
25440768-11	2015	Since recently published data have repeatedly reported an increase of immune deviations associated with paracetamol exposure at a young age, it appears important to better understand the possible negative impact of excessive and repetitive inhibitions of the physiological synthesis of prostaglandins by COX2s in childhood during which all immune mechanisms are built up at the intestinal submucosal level.	Prostaglandins	286-300	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	304-308
25500741-9	2015	Methylation-specific PCR and direct bisulfite sequencing revealed positive COX II gene methylation.	hydrogen sulfite	36-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-81
25500741-10	2015	AZA administration partly increased mRNA and protein expressions of COX II, and COX activity decreased by CSE and attenuated the toxic effects of CSE.	aza	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-74
25690564-0	2015	Design, synthesis and in vitro study of 5,6-diaryl-1,2,4-triazine-3-ylthioacetate derivatives as COX-2 and beta-amyloid aggregation inhibitors.	5,6-diaryl-1,2,4-triazine-3-ylthioacetate	40-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
25690564-1	2015	In order to find novel cyclooxygenase (COX)-2 inhibitors for treating inflammatory-based diseases such as Alzheimer"s disease (AD), an ethyl carboxylate side chain was added to 5-(4-chlorophenyl)-6-(4-(methylsulfonyl)phenyl)-3-(methylthio)-1,2,4-triazine (lead compound II) to maintain residual inhibition of COX-1 through interacting with Arg120.	ethyl carboxylate	135-152	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-45
25690564-1	2015	In order to find novel cyclooxygenase (COX)-2 inhibitors for treating inflammatory-based diseases such as Alzheimer"s disease (AD), an ethyl carboxylate side chain was added to 5-(4-chlorophenyl)-6-(4-(methylsulfonyl)phenyl)-3-(methylthio)-1,2,4-triazine (lead compound II) to maintain residual inhibition of COX-1 through interacting with Arg120.	5-(4-chlorophenyl)-6-(4-(methylsulfonyl)phenyl)-3-(methylthio)-1,2,4-triazine	177-254	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-45
25690564-1	2015	In order to find novel cyclooxygenase (COX)-2 inhibitors for treating inflammatory-based diseases such as Alzheimer"s disease (AD), an ethyl carboxylate side chain was added to 5-(4-chlorophenyl)-6-(4-(methylsulfonyl)phenyl)-3-(methylthio)-1,2,4-triazine (lead compound II) to maintain residual inhibition of COX-1 through interacting with Arg120.	lead compound ii	256-272	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-45
25662537-6	2015	The results showed that, in the presence of PMA, zinc treatment leads to reduce the production of ROS, which results in decrease of COX-2 expression and PGE2 release.	ros	98-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-137
25469667-0	2015	Co(II)-mediated effects of plain and plasma immersion ion implanted cobalt-chromium alloys on the osteogenic differentiation of human mesenchymal stem cells.	Cobalt	68-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
25469667-0	2015	Co(II)-mediated effects of plain and plasma immersion ion implanted cobalt-chromium alloys on the osteogenic differentiation of human mesenchymal stem cells.	Chromium	75-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
25469667-2	2015	CoCr surfaces modified by nitrogen plasma immersion ion implantation (PIII) are characterized by improved wear resistance but also showed increased Co(II) ion release under in vitro conditions.	Nitrogen	26-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	148-153
25646683-7	2015	It is hypothesized that 1) inflammatory mediators upregulate cyclooxygenase-2/prostaglandin E2 (COX-2/PGE2), which then in turn regulate E-cadherin expression in HNSCC; and 2) PGE2 downregulates E-cadherin via transcriptional repressors of E-cadherin (such as Snail) in HNSCC.	Dinoprostone	102-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-101
25646683-7	2015	It is hypothesized that 1) inflammatory mediators upregulate cyclooxygenase-2/prostaglandin E2 (COX-2/PGE2), which then in turn regulate E-cadherin expression in HNSCC; and 2) PGE2 downregulates E-cadherin via transcriptional repressors of E-cadherin (such as Snail) in HNSCC.	Dinoprostone	176-180	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-101
25620665-7	2015	In addition, Srxn1 appeared to influence the strength of TLR4 signaling pathway; the expression of COX-2, IL-6, and NOS2 were strongly induced by OGD/R and H2O2 in astrocyte cultures with Srxn1-shRNAs.	Hydrogen Peroxide	156-160	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-104
25612618-6	2015	On the basis of the resistance profile, we were able to successfully predict that a novel resveratrol-derived COX-2 inhibitor, M8, would be active against the vemurafenib-resistant but not the vemurafenib-sensitive melanoma cells.	Resveratrol	90-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-115
25612618-6	2015	On the basis of the resistance profile, we were able to successfully predict that a novel resveratrol-derived COX-2 inhibitor, M8, would be active against the vemurafenib-resistant but not the vemurafenib-sensitive melanoma cells.	Vemurafenib	159-170	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-115
25611163-4	2015	On the other hand, in linear trinuclear complex , in addition to the mu2-phenoxido and mu1,1-azido bridges with terminal octahedral Co(III) centres, the central Co(II) is bonded with two mutually trans-oxygen atoms of water molecules.	Oxygen	202-208	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	161-167
24581331-4	2015	Antibodies against human sRANKL and inhibitor of COX-2: NS398 were added to conditioned medium to investigate the inhibitory effect on osteoclastogenesis.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	56-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-54
25497868-6	2015	Significant inhibition of VEGF, angiopoietin 1, angiopoietin 2, platelet derived growth factor, COX-2, and TGFbeta secretion was observed in PC cell lines treated with UBS109, EF31 or curcumin.	UBS109	168-174	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-101
25497868-6	2015	Significant inhibition of VEGF, angiopoietin 1, angiopoietin 2, platelet derived growth factor, COX-2, and TGFbeta secretion was observed in PC cell lines treated with UBS109, EF31 or curcumin.	Curcumin	184-192	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-101
25611163-4	2015	On the other hand, in linear trinuclear complex , in addition to the mu2-phenoxido and mu1,1-azido bridges with terminal octahedral Co(III) centres, the central Co(II) is bonded with two mutually trans-oxygen atoms of water molecules.	Water	218-223	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	161-167
25497868-9	2015	Finally, we demonstrate for the first time that curcumin analogues EF31 and UBS109 induce the downregulation of HIF-1alpha, Hsp90, COX-2 and VEGF in tumor samples from xenograft models compared to untreated xenografts.	Curcumin	48-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-136
25611163-6	2015	In complex 3, the two terminal octahedral Co(III)N2O4 centers coordinate to the central penta-coordinated Co(II) ion through double phenoxido bridges along with the nitrogen atom of a terminal azido ligand.	PENTA	88-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-112
25497868-9	2015	Finally, we demonstrate for the first time that curcumin analogues EF31 and UBS109 induce the downregulation of HIF-1alpha, Hsp90, COX-2 and VEGF in tumor samples from xenograft models compared to untreated xenografts.	UBS109	76-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-136
25611163-6	2015	In complex 3, the two terminal octahedral Co(III)N2O4 centers coordinate to the central penta-coordinated Co(II) ion through double phenoxido bridges along with the nitrogen atom of a terminal azido ligand.	3',5-diazido-2',3'-dideoxyuridine	193-198	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-112
25611163-13	2015	Mechanistic investigations of the catalytic behaviors by X-band EPR spectroscopy and estimation of hydrogen peroxide formation indicate that the oxidation reaction proceeds through the reduction of Co(III) to Co(II).	Hydrogen Peroxide	99-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	209-215
25623286-0	2015	Inter-ligand azo (N=N) unit formation and stabilization of a Co(II)-diradical complex via metal-to-ligand dpi-ppi* back donation: synthesis, characterization, and theoretical study.	anthrone	13-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-67
25623286-0	2015	Inter-ligand azo (N=N) unit formation and stabilization of a Co(II)-diradical complex via metal-to-ligand dpi-ppi* back donation: synthesis, characterization, and theoretical study.	Metals	90-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-67
25623286-0	2015	Inter-ligand azo (N=N) unit formation and stabilization of a Co(II)-diradical complex via metal-to-ligand dpi-ppi* back donation: synthesis, characterization, and theoretical study.	dpi-ppi	106-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-67
25623286-1	2015	An azide (-N3) group attached at the -ortho carbon atom to the aniline moiety of 2-anilino-4,6-di-tert-butylphenol formed a diradical-containing Co(II) complex via inter-ligand azo (N=N) bond formation.	Azides	3-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-151
25623286-1	2015	An azide (-N3) group attached at the -ortho carbon atom to the aniline moiety of 2-anilino-4,6-di-tert-butylphenol formed a diradical-containing Co(II) complex via inter-ligand azo (N=N) bond formation.	Carbon	44-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-151
25623286-1	2015	An azide (-N3) group attached at the -ortho carbon atom to the aniline moiety of 2-anilino-4,6-di-tert-butylphenol formed a diradical-containing Co(II) complex via inter-ligand azo (N=N) bond formation.	aniline	63-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-151
25623286-1	2015	An azide (-N3) group attached at the -ortho carbon atom to the aniline moiety of 2-anilino-4,6-di-tert-butylphenol formed a diradical-containing Co(II) complex via inter-ligand azo (N=N) bond formation.	2-anilino-4,6-di-tert-butylphenol	81-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-151
25548276-3	2015	COX-2 is degraded via endoplasmic reticulum (ER)-associated degradation (ERAD) following post-translational glycosylation of Asn-594.	Asparagine	125-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
25623286-1	2015	An azide (-N3) group attached at the -ortho carbon atom to the aniline moiety of 2-anilino-4,6-di-tert-butylphenol formed a diradical-containing Co(II) complex via inter-ligand azo (N=N) bond formation.	anthrone	177-180	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-151
25548276-8	2015	Substituting this sequence with KDEL, a robust ER retention signal, concentrated COX-2 in the ER where it was stable and slowly glycosylated on Asn-594.	Asparagine	144-147	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-86
25218230-1	2015	New Co(II), Ni(II) and Cu(II) complexes derived from tetradentate macrocyclic nitrogen ligand, (1E,4E,8E,12E)-5,8,13,16-tetramethyl-1,4,9,12-tetrazacyclohexadeca-4,8,12,16-tetraene (EDHDH) have been synthesized.	cu(ii)	23-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
25548276-10	2015	We conclude that N-glycosylation of Asn-594 of COX-2 occurs in the ER, leading to anterograde movement of COX-2 to the Golgi where the Asn-594-linked glycan is trimmed prior to retrograde COX-2 transport to the ER for ERAD.	Nitrogen	17-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
25548276-10	2015	We conclude that N-glycosylation of Asn-594 of COX-2 occurs in the ER, leading to anterograde movement of COX-2 to the Golgi where the Asn-594-linked glycan is trimmed prior to retrograde COX-2 transport to the ER for ERAD.	Nitrogen	17-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-111
25548276-10	2015	We conclude that N-glycosylation of Asn-594 of COX-2 occurs in the ER, leading to anterograde movement of COX-2 to the Golgi where the Asn-594-linked glycan is trimmed prior to retrograde COX-2 transport to the ER for ERAD.	Nitrogen	17-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-111
25548276-10	2015	We conclude that N-glycosylation of Asn-594 of COX-2 occurs in the ER, leading to anterograde movement of COX-2 to the Golgi where the Asn-594-linked glycan is trimmed prior to retrograde COX-2 transport to the ER for ERAD.	Asparagine	36-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
25548276-10	2015	We conclude that N-glycosylation of Asn-594 of COX-2 occurs in the ER, leading to anterograde movement of COX-2 to the Golgi where the Asn-594-linked glycan is trimmed prior to retrograde COX-2 transport to the ER for ERAD.	Asparagine	36-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-111
25548276-10	2015	We conclude that N-glycosylation of Asn-594 of COX-2 occurs in the ER, leading to anterograde movement of COX-2 to the Golgi where the Asn-594-linked glycan is trimmed prior to retrograde COX-2 transport to the ER for ERAD.	Asparagine	36-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-111
25548276-10	2015	We conclude that N-glycosylation of Asn-594 of COX-2 occurs in the ER, leading to anterograde movement of COX-2 to the Golgi where the Asn-594-linked glycan is trimmed prior to retrograde COX-2 transport to the ER for ERAD.	Asparagine	135-138	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
25548276-10	2015	We conclude that N-glycosylation of Asn-594 of COX-2 occurs in the ER, leading to anterograde movement of COX-2 to the Golgi where the Asn-594-linked glycan is trimmed prior to retrograde COX-2 transport to the ER for ERAD.	Asparagine	135-138	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-111
25548276-10	2015	We conclude that N-glycosylation of Asn-594 of COX-2 occurs in the ER, leading to anterograde movement of COX-2 to the Golgi where the Asn-594-linked glycan is trimmed prior to retrograde COX-2 transport to the ER for ERAD.	Asparagine	135-138	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-111
25548276-10	2015	We conclude that N-glycosylation of Asn-594 of COX-2 occurs in the ER, leading to anterograde movement of COX-2 to the Golgi where the Asn-594-linked glycan is trimmed prior to retrograde COX-2 transport to the ER for ERAD.	Polysaccharides	150-156	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
25548276-10	2015	We conclude that N-glycosylation of Asn-594 of COX-2 occurs in the ER, leading to anterograde movement of COX-2 to the Golgi where the Asn-594-linked glycan is trimmed prior to retrograde COX-2 transport to the ER for ERAD.	Polysaccharides	150-156	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-111
25548276-10	2015	We conclude that N-glycosylation of Asn-594 of COX-2 occurs in the ER, leading to anterograde movement of COX-2 to the Golgi where the Asn-594-linked glycan is trimmed prior to retrograde COX-2 transport to the ER for ERAD.	Polysaccharides	150-156	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-111
25548276-14	2015	We propose that cytosolic phospholipase A2alpha, COX-2, and mPGES-1 in the Golgi comprise a dedicated system for COX-2-dependent PGE2 biosynthesis.	Dinoprostone	129-133	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-54
25548276-14	2015	We propose that cytosolic phospholipase A2alpha, COX-2, and mPGES-1 in the Golgi comprise a dedicated system for COX-2-dependent PGE2 biosynthesis.	Dinoprostone	129-133	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-118
25233028-6	2015	The photocatalytic activity was found to be more efficient in the presence of Ni(II) complexes than the Co(II) complex.	Nickel(2+)	78-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-110
25238187-4	2015	The sensor properties of the Schiff bases were examined and color changes were observed upon addition of the metal cations, such as Hg(II), Cu(II), Co(II) and Al(III).	Schiff Bases	29-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	148-154
25280332-0	2015	Spectroscopic properties of a series of Co(II) coordination polymers and the influence of Co(II) coordination environment on photoelectric property.	Polymers	60-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
25280332-2	2015	The structural analyses indicate that the coordination numbers of the Co(II) ions are 4, 5, 6 and 6 for the polymers 1-4, respectively.	Polymers	108-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-76
25280332-3	2015	And polymers 1 and 2 exhibit 3D structure formed by suc(2-) and pdc(2-) anions bridging Co(II) ions, respectively.	Polymers	4-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-94
25710724-0	2015	Licochalcone A, a polyphenol present in licorice, suppresses UV-induced COX-2 expression by targeting PI3K, MEK1, and B-Raf.	licochalcone A	0-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
25710724-0	2015	Licochalcone A, a polyphenol present in licorice, suppresses UV-induced COX-2 expression by targeting PI3K, MEK1, and B-Raf.	Polyphenols	18-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
25710724-7	2015	Here, we show that LicoA, a major chalcone compound of licorice, effectively inhibits sUV-induced COX-2 expression and prostaglandin E2 PGE2 generation through the inhibition of activator protein 1 AP-1 transcriptional activity, with an effect that is notably more potent than Gc.	licochalcone A	19-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-103
25605013-6	2015	Biochemical studies revealed that galectin-1 knockdown led to the suppression of COX-2/PGE2 and AKT/mTOR pathways, indicating galectin-1 might control the phenotypes of CSCs by regulating these signaling pathways.	Dinoprostone	87-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-86
25759598-4	2015	All available NSAIDs, including acetaminophen and aspirin, are associated with potential side effects, particularly gastrointestinal and cardiovascular effects, related to their relative selectivity for COX-1 and COX-2.	Acetaminophen	32-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	213-218
25759598-4	2015	All available NSAIDs, including acetaminophen and aspirin, are associated with potential side effects, particularly gastrointestinal and cardiovascular effects, related to their relative selectivity for COX-1 and COX-2.	Aspirin	50-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	213-218
25607569-5	2015	Under a Fe/M weight ratio of 5:1, Co(II), Ni(II), and Cu(II) were removed by the formation of MFe2O4 spinel phase and partially through their structural incorporation into octahedral positions of gamma-Fe2O3 (maghemite) nanoparticles.	mfe2o4	94-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-40
25607569-5	2015	Under a Fe/M weight ratio of 5:1, Co(II), Ni(II), and Cu(II) were removed by the formation of MFe2O4 spinel phase and partially through their structural incorporation into octahedral positions of gamma-Fe2O3 (maghemite) nanoparticles.	gamma-fe2o3	196-207	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-40
25607569-5	2015	Under a Fe/M weight ratio of 5:1, Co(II), Ni(II), and Cu(II) were removed by the formation of MFe2O4 spinel phase and partially through their structural incorporation into octahedral positions of gamma-Fe2O3 (maghemite) nanoparticles.	ferric oxide	209-218	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-40
25549802-3	2015	Using spectroscopic methods and competitive titrations with Zn(II), Co(II), and Ni(II) ions, we determined conditional dissociation constants for Zn(II) complexes of PARPzf1 and PARPzf2 at pH 7.4 (HEPESbuffer) as 26 +- 4 nM and 4 +- 1 pM, respectively.	Zinc	146-152	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-73
25632988-3	2015	With M = Fe, Co, or Ni, electrochemical formation of the Ta-Ta bonds is accompanied by a partial reduction of the Fe(II), Co(II), or Ni(II) to Fe(0), Co(0), or Ni(0).	Iron	9-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-128
25632988-3	2015	With M = Fe, Co, or Ni, electrochemical formation of the Ta-Ta bonds is accompanied by a partial reduction of the Fe(II), Co(II), or Ni(II) to Fe(0), Co(0), or Ni(0).	Cobalt	13-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-128
25460694-5	2015	EPR and CV of Si/Al-PAEA=PyCA@CoNP confirmed that most of the covalently bond active sites of the nano-adsorbent are in the form of Co(II) ions.	Aluminum	17-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-138
25588991-0	2015	The ligand field of the azido ligand: insights into bonding parameters and magnetic anisotropy in a Co(II)-azido complex.	3',5-diazido-2',3'-dideoxyuridine	24-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-106
25588991-7	2015	Calculations were performed on 1 and a related four-coordinate Co(II)-azido complex lacking a fifth axial ligand (2).	3',5-diazido-2',3'-dideoxyuridine	70-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-69
25533319-2	2015	An initial Co(II) amine complex 1 is prone to aerial oxidation yielding a Co(III) imine complex 2 that is further converted into an amide complex 4 in presence of adventitious water.	co(iii) imine	74-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-16
25533319-2	2015	An initial Co(II) amine complex 1 is prone to aerial oxidation yielding a Co(III) imine complex 2 that is further converted into an amide complex 4 in presence of adventitious water.	Amides	132-137	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-16
25533319-2	2015	An initial Co(II) amine complex 1 is prone to aerial oxidation yielding a Co(III) imine complex 2 that is further converted into an amide complex 4 in presence of adventitious water.	Water	176-181	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-16
25533319-3	2015	Introduction of an N-methyl protecting group to the ligand inhibits this oxidation and gives rise to the Co(II) species 5.	n-methyl	19-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-110
25533319-4	2015	Both the Co(III) 4 and Co(II) 5 show electrocatalytic H2 generation in weakly acidic media as well as in water.	Hydrogen	54-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	9-14
25533319-4	2015	Both the Co(III) 4 and Co(II) 5 show electrocatalytic H2 generation in weakly acidic media as well as in water.	Water	105-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	9-14
25537966-1	2015	We are reporting two new mixed valent Co(ii)/Co(iii) polynuclear complexes, {Co(II)6Co(III)3} and {Co(II)Co(III)4}, bearing different amount of Co(ii) ions in their cores, through the employment of the multidentate triethanolamine (teaH3) ligand in different stoichiometric ratios.	co(iii)	45-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-44
25537966-1	2015	We are reporting two new mixed valent Co(ii)/Co(iii) polynuclear complexes, {Co(II)6Co(III)3} and {Co(II)Co(III)4}, bearing different amount of Co(ii) ions in their cores, through the employment of the multidentate triethanolamine (teaH3) ligand in different stoichiometric ratios.	co(iii)	45-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-82
25537966-1	2015	We are reporting two new mixed valent Co(ii)/Co(iii) polynuclear complexes, {Co(II)6Co(III)3} and {Co(II)Co(III)4}, bearing different amount of Co(ii) ions in their cores, through the employment of the multidentate triethanolamine (teaH3) ligand in different stoichiometric ratios.	co(iii)	45-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-89
25537966-1	2015	We are reporting two new mixed valent Co(ii)/Co(iii) polynuclear complexes, {Co(II)6Co(III)3} and {Co(II)Co(III)4}, bearing different amount of Co(ii) ions in their cores, through the employment of the multidentate triethanolamine (teaH3) ligand in different stoichiometric ratios.	co(iii)	45-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	144-150
25537966-1	2015	We are reporting two new mixed valent Co(ii)/Co(iii) polynuclear complexes, {Co(II)6Co(III)3} and {Co(II)Co(III)4}, bearing different amount of Co(ii) ions in their cores, through the employment of the multidentate triethanolamine (teaH3) ligand in different stoichiometric ratios.	co(iii)4	105-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-44
25537966-1	2015	We are reporting two new mixed valent Co(ii)/Co(iii) polynuclear complexes, {Co(II)6Co(III)3} and {Co(II)Co(III)4}, bearing different amount of Co(ii) ions in their cores, through the employment of the multidentate triethanolamine (teaH3) ligand in different stoichiometric ratios.	co(iii)4	105-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	144-150
25537966-1	2015	We are reporting two new mixed valent Co(ii)/Co(iii) polynuclear complexes, {Co(II)6Co(III)3} and {Co(II)Co(III)4}, bearing different amount of Co(ii) ions in their cores, through the employment of the multidentate triethanolamine (teaH3) ligand in different stoichiometric ratios.	triethanolamine	215-230	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-44
25537966-1	2015	We are reporting two new mixed valent Co(ii)/Co(iii) polynuclear complexes, {Co(II)6Co(III)3} and {Co(II)Co(III)4}, bearing different amount of Co(ii) ions in their cores, through the employment of the multidentate triethanolamine (teaH3) ligand in different stoichiometric ratios.	triethanolamine	215-230	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	144-150
25537966-1	2015	We are reporting two new mixed valent Co(ii)/Co(iii) polynuclear complexes, {Co(II)6Co(III)3} and {Co(II)Co(III)4}, bearing different amount of Co(ii) ions in their cores, through the employment of the multidentate triethanolamine (teaH3) ligand in different stoichiometric ratios.	teah3)	232-238	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-44
25537966-1	2015	We are reporting two new mixed valent Co(ii)/Co(iii) polynuclear complexes, {Co(II)6Co(III)3} and {Co(II)Co(III)4}, bearing different amount of Co(ii) ions in their cores, through the employment of the multidentate triethanolamine (teaH3) ligand in different stoichiometric ratios.	teah3)	232-238	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	144-150
25583367-1	2015	Several members of the recently reported peroxy chamigrane family of natural products were synthesized via a distereoselective route with a novel facial-selective epoxidation of a spiroundecadiene, a facile epoxide rearrangement, and a Co(II)-mediated silylperoxidation as the key steps.	peroxy chamigrane	41-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	236-241
24315445-1	2015	The reactions of Co(II) sources with N-salicylidene-o-aminophenol (H2saph), N-salicylidene-o-amino-4-methylphenol (H2saph-4Me) and N-salicylidene-o-amino-4-chlorophenol (H2saph-4Cl) were studied in MeOH.	N-salicylidene-o-aminophenol	37-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22
24315445-1	2015	The reactions of Co(II) sources with N-salicylidene-o-aminophenol (H2saph), N-salicylidene-o-amino-4-methylphenol (H2saph-4Me) and N-salicylidene-o-amino-4-chlorophenol (H2saph-4Cl) were studied in MeOH.	h2saph	67-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22
24315445-1	2015	The reactions of Co(II) sources with N-salicylidene-o-aminophenol (H2saph), N-salicylidene-o-amino-4-methylphenol (H2saph-4Me) and N-salicylidene-o-amino-4-chlorophenol (H2saph-4Cl) were studied in MeOH.	n-salicylidene-o-amino-4-methylphenol	76-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22
24315445-1	2015	The reactions of Co(II) sources with N-salicylidene-o-aminophenol (H2saph), N-salicylidene-o-amino-4-methylphenol (H2saph-4Me) and N-salicylidene-o-amino-4-chlorophenol (H2saph-4Cl) were studied in MeOH.	h2saph-4me	115-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22
24315445-1	2015	The reactions of Co(II) sources with N-salicylidene-o-aminophenol (H2saph), N-salicylidene-o-amino-4-methylphenol (H2saph-4Me) and N-salicylidene-o-amino-4-chlorophenol (H2saph-4Cl) were studied in MeOH.	n-salicylidene-o-amino-4-chlorophenol	131-168	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22
24315445-1	2015	The reactions of Co(II) sources with N-salicylidene-o-aminophenol (H2saph), N-salicylidene-o-amino-4-methylphenol (H2saph-4Me) and N-salicylidene-o-amino-4-chlorophenol (H2saph-4Cl) were studied in MeOH.	h2saph-4cl	170-180	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22
24315445-1	2015	The reactions of Co(II) sources with N-salicylidene-o-aminophenol (H2saph), N-salicylidene-o-amino-4-methylphenol (H2saph-4Me) and N-salicylidene-o-amino-4-chlorophenol (H2saph-4Cl) were studied in MeOH.	Methanol	198-202	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22
25440581-0	2015	Synthesis of novel binary and ternary complexes derived from 1-(2-hydroxy benzoyl)-4-phenylthiosemicarbazide (L(1)) and 2,2"-dipyridyl (L(2)) with Co(II), Cu(II) and Zn(II) salts.	1-(2-hydroxy benzoyl)-4-phenylthiosemicarbazide	61-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-153
25440581-0	2015	Synthesis of novel binary and ternary complexes derived from 1-(2-hydroxy benzoyl)-4-phenylthiosemicarbazide (L(1)) and 2,2"-dipyridyl (L(2)) with Co(II), Cu(II) and Zn(II) salts.	Deferiprone	110-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-153
25440581-0	2015	Synthesis of novel binary and ternary complexes derived from 1-(2-hydroxy benzoyl)-4-phenylthiosemicarbazide (L(1)) and 2,2"-dipyridyl (L(2)) with Co(II), Cu(II) and Zn(II) salts.	2,2'-Dipyridyl	120-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-153
25440581-0	2015	Synthesis of novel binary and ternary complexes derived from 1-(2-hydroxy benzoyl)-4-phenylthiosemicarbazide (L(1)) and 2,2"-dipyridyl (L(2)) with Co(II), Cu(II) and Zn(II) salts.	Threonine	136-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-153
25440581-0	2015	Synthesis of novel binary and ternary complexes derived from 1-(2-hydroxy benzoyl)-4-phenylthiosemicarbazide (L(1)) and 2,2"-dipyridyl (L(2)) with Co(II), Cu(II) and Zn(II) salts.	cu(ii)	155-161	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-153
25440581-0	2015	Synthesis of novel binary and ternary complexes derived from 1-(2-hydroxy benzoyl)-4-phenylthiosemicarbazide (L(1)) and 2,2"-dipyridyl (L(2)) with Co(II), Cu(II) and Zn(II) salts.	zn(ii) salts	166-178	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-153
25440581-1	2015	The complexes derived the reactions of 1-(2-hydroxybenzoyl)-4-phenylthiosemicarbazide (L(1)) with MX2 (M = Co(II), Cu(II) and Zn(II) ions; X = Cl(-) in case of Co(II) and Cu(II) ions, Cl(-) and Ac(-) in case of Zn(II)) in EtOH, were synthesized and characterized.	CHEMBL3633780	39-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-113
25440581-1	2015	The complexes derived the reactions of 1-(2-hydroxybenzoyl)-4-phenylthiosemicarbazide (L(1)) with MX2 (M = Co(II), Cu(II) and Zn(II) ions; X = Cl(-) in case of Co(II) and Cu(II) ions, Cl(-) and Ac(-) in case of Zn(II)) in EtOH, were synthesized and characterized.	CHEMBL3633780	39-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	160-166
25440581-1	2015	The complexes derived the reactions of 1-(2-hydroxybenzoyl)-4-phenylthiosemicarbazide (L(1)) with MX2 (M = Co(II), Cu(II) and Zn(II) ions; X = Cl(-) in case of Co(II) and Cu(II) ions, Cl(-) and Ac(-) in case of Zn(II)) in EtOH, were synthesized and characterized.	Zinc	126-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	160-166
25440581-1	2015	The complexes derived the reactions of 1-(2-hydroxybenzoyl)-4-phenylthiosemicarbazide (L(1)) with MX2 (M = Co(II), Cu(II) and Zn(II) ions; X = Cl(-) in case of Co(II) and Cu(II) ions, Cl(-) and Ac(-) in case of Zn(II)) in EtOH, were synthesized and characterized.	Zinc	126-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	160-166
25459625-1	2015	Spectroscopic (IR, Raman, NMR, UV-visible, and ESR), and structural studies of the ligand 3-methoxy-N-salicylidene-o-amino phenol (H2L) and its synthesized complexes with some transition metal ions (Mn(II), Co(II), Ni(II)), Cu(II) and Zn(II)) were recorded and analyzed.	3-methoxy-N-salicylidene-o-amino phenol	90-129	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	207-213
25459625-1	2015	Spectroscopic (IR, Raman, NMR, UV-visible, and ESR), and structural studies of the ligand 3-methoxy-N-salicylidene-o-amino phenol (H2L) and its synthesized complexes with some transition metal ions (Mn(II), Co(II), Ni(II)), Cu(II) and Zn(II)) were recorded and analyzed.	h2l	131-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	207-213
25459625-3	2015	The metal complexes were found to have The structural formula ML H2O and the metal ions Mn(II), Co(II), Ni(II)) and Zn(II) were found to form tetrahedral complexes with the ligand whereas Cu(II) formed a square planar one.	Metals	4-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-102
25459625-3	2015	The metal complexes were found to have The structural formula ML H2O and the metal ions Mn(II), Co(II), Ni(II)) and Zn(II) were found to form tetrahedral complexes with the ligand whereas Cu(II) formed a square planar one.	Water	65-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-102
25459625-3	2015	The metal complexes were found to have The structural formula ML H2O and the metal ions Mn(II), Co(II), Ni(II)) and Zn(II) were found to form tetrahedral complexes with the ligand whereas Cu(II) formed a square planar one.	Metals	77-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-102
25459625-3	2015	The metal complexes were found to have The structural formula ML H2O and the metal ions Mn(II), Co(II), Ni(II)) and Zn(II) were found to form tetrahedral complexes with the ligand whereas Cu(II) formed a square planar one.	cu(ii)	188-194	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-102
25398544-5	2015	The aim of this study was to examine the effect of micromolar concentrations of sodium orthovanadate, Na3VO4, on the activity and expression of cyclooxygenases: COX-1 and COX-2.	Sodium orthovanadate	80-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	171-176
25398544-5	2015	The aim of this study was to examine the effect of micromolar concentrations of sodium orthovanadate, Na3VO4, on the activity and expression of cyclooxygenases: COX-1 and COX-2.	Sodium orthovanadate	102-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	171-176
25398544-8	2015	The use of a COX-2 inhibitor, NS-398, revealed that this effect was independent of changes in the activity of COX-2.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	30-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
25398544-9	2015	Western blotting analysis showed that sodium orthovanadate increased the expression of COX-2 when used with NS-398.	Sodium orthovanadate	38-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-92
25398544-9	2015	Western blotting analysis showed that sodium orthovanadate increased the expression of COX-2 when used with NS-398.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	108-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-92
24965577-0	2015	Autocrine prostaglandin E2 signaling promotes promonocytic leukemia cell survival via COX-2 expression and MAPK pathway.	Dinoprostone	10-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-91
24965577-1	2015	The COX-2/PGE2 pathway has been implicated in the occurrence and progression of cancer.	Dinoprostone	10-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
24965577-2	2015	The underlying mechanisms facilitating the production of COX-2 and its mediator, PGE2, in cancer survival remain unknown.	Dinoprostone	81-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-62
24965577-3	2015	Herein, we investigated PGE2-induced COX-2 expression and signaling in HL-60 cells following menadione treatment.	Dinoprostone	24-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-42
24965577-3	2015	Herein, we investigated PGE2-induced COX-2 expression and signaling in HL-60 cells following menadione treatment.	Vitamin K 3	93-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-42
24965577-5	2015	PGE2 not only induced COX-2 expression, but also prevented casapse-3, PARP, and lamin B cleavage.	Dinoprostone	0-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-27
24965577-6	2015	Silencing and inhibition of COX-2 with siRNA transfection or treatment with indomethacin led to a pronounced reduction of the extracellular levels of PGEv, and restored the menadione- induced cell death.	Indomethacin	76-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
24965577-6	2015	Silencing and inhibition of COX-2 with siRNA transfection or treatment with indomethacin led to a pronounced reduction of the extracellular levels of PGEv, and restored the menadione- induced cell death.	Vitamin K 3	173-182	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
24965577-7	2015	In addition, pretreatment of cells with the MEK inhibitor PD98059 and the PKA inhibitor H89 abrogated the PGE2-induced expression of COX-2, suggesting involvement of the MAPK and PKA pathways.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	58-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	133-138
24965577-7	2015	In addition, pretreatment of cells with the MEK inhibitor PD98059 and the PKA inhibitor H89 abrogated the PGE2-induced expression of COX-2, suggesting involvement of the MAPK and PKA pathways.	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	88-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	133-138
24965577-7	2015	In addition, pretreatment of cells with the MEK inhibitor PD98059 and the PKA inhibitor H89 abrogated the PGE2-induced expression of COX-2, suggesting involvement of the MAPK and PKA pathways.	Dinoprostone	106-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	133-138
25685314-0	2015	Stereoselective Radical C-H Alkylation with Acceptor/Acceptor-Substituted Diazo Reagents via Co(II)-Based Metalloradical Catalysis.	diazo reagents	74-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-98
25685314-1	2015	Co(II)-based metalloradical catalysis has been, for the first time, successfully applied for asymmetric intramolecular C-H alkylation of acceptor/acceptor-substituted diazo reagents.	diazo reagents	167-181	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
25685314-2	2015	Through the design and synthesis of a new D2-symmetric chiral amidoporphyrin as the supporting ligand, the Co(II)-based metalloradical system, which operates at room temperature, is capable of 1,5-C-H alkylation of alpha-methoxycarbonyl-alpha-diazosulfones with a broad range of electronic properties, providing the 5-membered sulfolane derivatives in high yields with excellent diastereoselectivity and enantioselectivity.	amidoporphyrin	62-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-112
25685314-2	2015	Through the design and synthesis of a new D2-symmetric chiral amidoporphyrin as the supporting ligand, the Co(II)-based metalloradical system, which operates at room temperature, is capable of 1,5-C-H alkylation of alpha-methoxycarbonyl-alpha-diazosulfones with a broad range of electronic properties, providing the 5-membered sulfolane derivatives in high yields with excellent diastereoselectivity and enantioselectivity.	sulfolane	327-336	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-112
25399887-13	2015	Furthermore, the ERK inhibitor pd98059 (30 mumol/L) and the JNK inhibitor sp600125 (10 mumol/L) blocked CRP-induced COX-1 and COX-2 expression for 12 h. Together, the findings of the present study suggest that CRP can promote the development of the no-reflow phenomenon by increasing COX-1 and COX-2 expression, which is regulated, in part, via ERK and JNK activity.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	31-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-131
25399887-13	2015	Furthermore, the ERK inhibitor pd98059 (30 mumol/L) and the JNK inhibitor sp600125 (10 mumol/L) blocked CRP-induced COX-1 and COX-2 expression for 12 h. Together, the findings of the present study suggest that CRP can promote the development of the no-reflow phenomenon by increasing COX-1 and COX-2 expression, which is regulated, in part, via ERK and JNK activity.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	31-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	294-299
25399887-13	2015	Furthermore, the ERK inhibitor pd98059 (30 mumol/L) and the JNK inhibitor sp600125 (10 mumol/L) blocked CRP-induced COX-1 and COX-2 expression for 12 h. Together, the findings of the present study suggest that CRP can promote the development of the no-reflow phenomenon by increasing COX-1 and COX-2 expression, which is regulated, in part, via ERK and JNK activity.	pyrazolanthrone	74-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-131
25399887-13	2015	Furthermore, the ERK inhibitor pd98059 (30 mumol/L) and the JNK inhibitor sp600125 (10 mumol/L) blocked CRP-induced COX-1 and COX-2 expression for 12 h. Together, the findings of the present study suggest that CRP can promote the development of the no-reflow phenomenon by increasing COX-1 and COX-2 expression, which is regulated, in part, via ERK and JNK activity.	pyrazolanthrone	74-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	294-299
25342287-5	2015	Notably, Nrf2 siRNA and the inhibitors of COX-2 and NOX attenuated the inhibition of propofol on ROS production.	Propofol	85-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47
25342287-5	2015	Notably, Nrf2 siRNA and the inhibitors of COX-2 and NOX attenuated the inhibition of propofol on ROS production.	Reactive Oxygen Species	97-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47
25515365-0	2015	The effect of COX-2-selective meloxicam on the myocardial, vascular and renal risks: a systematic review.	Meloxicam	30-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
25973134-6	2015	Taken together, it could conclude that PA might inhibit proliferation and invasion of ovarian carcinoma cell through decreasing beta-catenin and COX-2 expression and increasing E-cadherin expression.	pachymic acid	39-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-150
25458528-4	2015	Our results indicated that selenium supplementation, as selenite, decreased acetylation of histone H4 at K12 and K16 in COX-2 and TNFalpha promoters, and of the p65 subunit of the redox sensitive transcription factor NFkappaB in primary and immortalized macrophages.	Selenium	27-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-125
25458528-4	2015	Our results indicated that selenium supplementation, as selenite, decreased acetylation of histone H4 at K12 and K16 in COX-2 and TNFalpha promoters, and of the p65 subunit of the redox sensitive transcription factor NFkappaB in primary and immortalized macrophages.	Selenious Acid	56-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-125
25379992-6	2015	Procyanidin B2 mediated inhibition of inflammasome activation includes the inactivation of the NF-kappaB signalling pathway, the first stage required for the transcription of inflammasome precursors, through the inhibition of p65 nuclear expression and DNA binding, resulting in the transcriptional repression of target genes, such as COX2 , iNOS and production of IL-6 and NO.	procyanidin B2	0-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	335-339
25483152-6	2015	Specific inhibition of COX-2 activity by nimesulide further confirmed that miR-26b was able to regulate the cell proliferation and metastasis of the human tongue squamous cell carcinoma cells through a COX-2-dependent mechanism.	nimesulide	41-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-28
25500692-9	2015	Kaempferol-treated cells also led to a decrease in p-Akt, p-ERK and COX-2 expression levels.	kaempferol	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-73
25687049-3	2015	Recent studies showed Dox-induced coexpression of COX2 and MDR1 genes in human leukaemia cells, and whether Dox-induced MDR1 up-regulation in acute leukaemia cells is dependent on COX2-transcriptional activity and thus might be overcome or prevented with COX2-promotor inhibitor quercetin interfering with COX2 expression and activity.	Doxorubicin	22-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-54
25687049-3	2015	Recent studies showed Dox-induced coexpression of COX2 and MDR1 genes in human leukaemia cells, and whether Dox-induced MDR1 up-regulation in acute leukaemia cells is dependent on COX2-transcriptional activity and thus might be overcome or prevented with COX2-promotor inhibitor quercetin interfering with COX2 expression and activity.	Doxorubicin	108-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	180-184
25687049-3	2015	Recent studies showed Dox-induced coexpression of COX2 and MDR1 genes in human leukaemia cells, and whether Dox-induced MDR1 up-regulation in acute leukaemia cells is dependent on COX2-transcriptional activity and thus might be overcome or prevented with COX2-promotor inhibitor quercetin interfering with COX2 expression and activity.	Doxorubicin	108-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	180-184
25687049-3	2015	Recent studies showed Dox-induced coexpression of COX2 and MDR1 genes in human leukaemia cells, and whether Dox-induced MDR1 up-regulation in acute leukaemia cells is dependent on COX2-transcriptional activity and thus might be overcome or prevented with COX2-promotor inhibitor quercetin interfering with COX2 expression and activity.	Doxorubicin	108-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	180-184
25687049-3	2015	Recent studies showed Dox-induced coexpression of COX2 and MDR1 genes in human leukaemia cells, and whether Dox-induced MDR1 up-regulation in acute leukaemia cells is dependent on COX2-transcriptional activity and thus might be overcome or prevented with COX2-promotor inhibitor quercetin interfering with COX2 expression and activity.	Quercetin	279-288	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	180-184
25687049-3	2015	Recent studies showed Dox-induced coexpression of COX2 and MDR1 genes in human leukaemia cells, and whether Dox-induced MDR1 up-regulation in acute leukaemia cells is dependent on COX2-transcriptional activity and thus might be overcome or prevented with COX2-promotor inhibitor quercetin interfering with COX2 expression and activity.	Quercetin	279-288	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	180-184
25687049-3	2015	Recent studies showed Dox-induced coexpression of COX2 and MDR1 genes in human leukaemia cells, and whether Dox-induced MDR1 up-regulation in acute leukaemia cells is dependent on COX2-transcriptional activity and thus might be overcome or prevented with COX2-promotor inhibitor quercetin interfering with COX2 expression and activity.	Quercetin	279-288	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	180-184
25687049-4	2015	This study was purposed to investigate the impacts of quercetin on Dox-induced mRNA expression of MDR1 and COX2 genes in HL-60 leukemia cells.	Quercetin	54-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-111
25687049-4	2015	This study was purposed to investigate the impacts of quercetin on Dox-induced mRNA expression of MDR1 and COX2 genes in HL-60 leukemia cells.	Doxorubicin	67-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-111
25687049-6	2015	RESULTS: The incubation of HL-60 cells with Dox not only up-regulated MDR1 mRNA, but also COX2 mRNA expression, and after co-incubation with quercetin or celecoxib, Dox-induced overexpression of MDR1 and COX2 mRNA were reduced by quercetin, not by celecoxib, whereas PGE2 release was significantly decreased with subsequent enhancement of Dox cytotoxic efficacy by both of them.	Doxorubicin	44-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-94
25687049-6	2015	RESULTS: The incubation of HL-60 cells with Dox not only up-regulated MDR1 mRNA, but also COX2 mRNA expression, and after co-incubation with quercetin or celecoxib, Dox-induced overexpression of MDR1 and COX2 mRNA were reduced by quercetin, not by celecoxib, whereas PGE2 release was significantly decreased with subsequent enhancement of Dox cytotoxic efficacy by both of them.	Doxorubicin	44-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	204-208
25687049-6	2015	RESULTS: The incubation of HL-60 cells with Dox not only up-regulated MDR1 mRNA, but also COX2 mRNA expression, and after co-incubation with quercetin or celecoxib, Dox-induced overexpression of MDR1 and COX2 mRNA were reduced by quercetin, not by celecoxib, whereas PGE2 release was significantly decreased with subsequent enhancement of Dox cytotoxic efficacy by both of them.	Quercetin	141-150	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-94
25687049-6	2015	RESULTS: The incubation of HL-60 cells with Dox not only up-regulated MDR1 mRNA, but also COX2 mRNA expression, and after co-incubation with quercetin or celecoxib, Dox-induced overexpression of MDR1 and COX2 mRNA were reduced by quercetin, not by celecoxib, whereas PGE2 release was significantly decreased with subsequent enhancement of Dox cytotoxic efficacy by both of them.	Quercetin	141-150	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	204-208
25687049-7	2015	CONCLUSIONS: Dox-induced MDR1 up-regulation may be dependent on COX2-transcriptional activity, not PGE2, suggesting that the existence of causal link between COX2 and MDR1 expression induced by Dox, and modulation of COX2 transcriptional expression by quercetin would not only sensitize leukemia cells to Dox, but also prevent the acquisition of MDR during chemotherapy.	Doxorubicin	13-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-68
25687049-7	2015	CONCLUSIONS: Dox-induced MDR1 up-regulation may be dependent on COX2-transcriptional activity, not PGE2, suggesting that the existence of causal link between COX2 and MDR1 expression induced by Dox, and modulation of COX2 transcriptional expression by quercetin would not only sensitize leukemia cells to Dox, but also prevent the acquisition of MDR during chemotherapy.	Doxorubicin	13-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	158-162
25687049-7	2015	CONCLUSIONS: Dox-induced MDR1 up-regulation may be dependent on COX2-transcriptional activity, not PGE2, suggesting that the existence of causal link between COX2 and MDR1 expression induced by Dox, and modulation of COX2 transcriptional expression by quercetin would not only sensitize leukemia cells to Dox, but also prevent the acquisition of MDR during chemotherapy.	Doxorubicin	13-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	158-162
25687049-7	2015	CONCLUSIONS: Dox-induced MDR1 up-regulation may be dependent on COX2-transcriptional activity, not PGE2, suggesting that the existence of causal link between COX2 and MDR1 expression induced by Dox, and modulation of COX2 transcriptional expression by quercetin would not only sensitize leukemia cells to Dox, but also prevent the acquisition of MDR during chemotherapy.	Doxorubicin	194-197	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-68
25687049-7	2015	CONCLUSIONS: Dox-induced MDR1 up-regulation may be dependent on COX2-transcriptional activity, not PGE2, suggesting that the existence of causal link between COX2 and MDR1 expression induced by Dox, and modulation of COX2 transcriptional expression by quercetin would not only sensitize leukemia cells to Dox, but also prevent the acquisition of MDR during chemotherapy.	Doxorubicin	194-197	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	158-162
25687049-7	2015	CONCLUSIONS: Dox-induced MDR1 up-regulation may be dependent on COX2-transcriptional activity, not PGE2, suggesting that the existence of causal link between COX2 and MDR1 expression induced by Dox, and modulation of COX2 transcriptional expression by quercetin would not only sensitize leukemia cells to Dox, but also prevent the acquisition of MDR during chemotherapy.	Doxorubicin	194-197	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	158-162
25687049-7	2015	CONCLUSIONS: Dox-induced MDR1 up-regulation may be dependent on COX2-transcriptional activity, not PGE2, suggesting that the existence of causal link between COX2 and MDR1 expression induced by Dox, and modulation of COX2 transcriptional expression by quercetin would not only sensitize leukemia cells to Dox, but also prevent the acquisition of MDR during chemotherapy.	Quercetin	252-261	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-68
25687049-7	2015	CONCLUSIONS: Dox-induced MDR1 up-regulation may be dependent on COX2-transcriptional activity, not PGE2, suggesting that the existence of causal link between COX2 and MDR1 expression induced by Dox, and modulation of COX2 transcriptional expression by quercetin would not only sensitize leukemia cells to Dox, but also prevent the acquisition of MDR during chemotherapy.	Quercetin	252-261	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	158-162
25687049-7	2015	CONCLUSIONS: Dox-induced MDR1 up-regulation may be dependent on COX2-transcriptional activity, not PGE2, suggesting that the existence of causal link between COX2 and MDR1 expression induced by Dox, and modulation of COX2 transcriptional expression by quercetin would not only sensitize leukemia cells to Dox, but also prevent the acquisition of MDR during chemotherapy.	Quercetin	252-261	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	158-162
25687049-7	2015	CONCLUSIONS: Dox-induced MDR1 up-regulation may be dependent on COX2-transcriptional activity, not PGE2, suggesting that the existence of causal link between COX2 and MDR1 expression induced by Dox, and modulation of COX2 transcriptional expression by quercetin would not only sensitize leukemia cells to Dox, but also prevent the acquisition of MDR during chemotherapy.	Doxorubicin	194-197	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-68
25687049-7	2015	CONCLUSIONS: Dox-induced MDR1 up-regulation may be dependent on COX2-transcriptional activity, not PGE2, suggesting that the existence of causal link between COX2 and MDR1 expression induced by Dox, and modulation of COX2 transcriptional expression by quercetin would not only sensitize leukemia cells to Dox, but also prevent the acquisition of MDR during chemotherapy.	Doxorubicin	194-197	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	158-162
25687049-7	2015	CONCLUSIONS: Dox-induced MDR1 up-regulation may be dependent on COX2-transcriptional activity, not PGE2, suggesting that the existence of causal link between COX2 and MDR1 expression induced by Dox, and modulation of COX2 transcriptional expression by quercetin would not only sensitize leukemia cells to Dox, but also prevent the acquisition of MDR during chemotherapy.	Doxorubicin	194-197	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	158-162
25778894-9	2015	RT-PCR examination showed that VEGF and COX-2 mRNA expression decreased by ursolic acid treatment.	ursolic acid	75-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
25529444-8	2015	Our results also indicate that GA pretreatment attenuates the up-regulation of COX-2 and iNOS.	Glatiramer Acetate	31-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-84
25494338-0	2015	Valence tautomeric dinuclear adducts of Co(II) diketonates with redox-active diquinones for the design of spin qubits: computational modeling.	redox-active diquinones	64-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
25494338-1	2015	The possibility of employing the mechanism of intramolecular electron transfer between metal and ligand centers in the valence tautomeric complexes formed as electrically neutral 2 : 1 adducts of Co(II) diketonates and redox-active tetradentate di-o-quinones, for quantum information processing, has been computationally studied using the DFT B3LYP*/6-311++G(d,p) method.	Metals	87-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	196-201
25494338-1	2015	The possibility of employing the mechanism of intramolecular electron transfer between metal and ligand centers in the valence tautomeric complexes formed as electrically neutral 2 : 1 adducts of Co(II) diketonates and redox-active tetradentate di-o-quinones, for quantum information processing, has been computationally studied using the DFT B3LYP*/6-311++G(d,p) method.	di-o-quinones	245-258	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	196-201
25494338-3	2015	These are exemplified by the adduct of bis-(hexafluoroacetylacetonate)Co(ii) with a diquinone containing dimethylene linker.	diquinone	84-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-75
25494338-3	2015	These are exemplified by the adduct of bis-(hexafluoroacetylacetonate)Co(ii) with a diquinone containing dimethylene linker.	chamazulene	105-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-75
25036645-4	2015	The DPPH free radical scavenging ability of phthalocyanine Co(II) and Zn(II) complexes on DPPH are 44.8% and 40.1% at 100 mg/L concentration, respectively.	1,1-diphenyl-2-picrylhydrazyl	4-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
25036645-4	2015	The DPPH free radical scavenging ability of phthalocyanine Co(II) and Zn(II) complexes on DPPH are 44.8% and 40.1% at 100 mg/L concentration, respectively.	phthalocyanine	44-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
25036645-4	2015	The DPPH free radical scavenging ability of phthalocyanine Co(II) and Zn(II) complexes on DPPH are 44.8% and 40.1% at 100 mg/L concentration, respectively.	1,1-diphenyl-2-picrylhydrazyl	90-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
25036645-5	2015	The phthalocyanine Co(II) and Cu(II) complexes show very strong ferrous ion chelating activity of 91.2% and 89.3% at concentration of 100 mg/L, respectively.	phthalocyanine	4-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-25
25064505-1	2015	Metal complexes of the chloride, nitrate and acetate salts of Co(II), Ni(II) Cu(II), Zn(II), Cd(II) or Hg(II) with 2,3-butanedione bis(isonicotinylhydrazone) [BBINH] have been synthesized and structurally characterized.	Metals	0-5	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-68
24724948-1	2015	OBJECTIVE: Previous studies examining the association between genetic variations in prostaglandin pathway and risk of head and neck cancer (HNC) have only included polymorphisms in the PTGS2 (COX2) gene.	Prostaglandins	84-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	192-196
25483263-6	2015	These findings suggest that 6 as a representative of these pyrazolecarboxamides function as anti-HCV agents via targeting COX-2 at both the transcription and translation levels.	pyrazolecarboxamides	59-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-127
25988128-8	2014	EGCG improved efficacy of cisplatin treatment in HeLa cells by regulating NFkappaB p65, COX-2, p-Akt, and p-mTOR pathways, whereas it increased the expression levels of Nrf2/HO-1 in combined therapy.	epigallocatechin gallate	0-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-93
25988128-8	2014	EGCG improved efficacy of cisplatin treatment in HeLa cells by regulating NFkappaB p65, COX-2, p-Akt, and p-mTOR pathways, whereas it increased the expression levels of Nrf2/HO-1 in combined therapy.	Cisplatin	26-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-93
25084240-3	2015	All of the M(II) (Co(II) or Ni(II)) ions for the cobalt(II) or nickel(II) complexes are six-coordinated and have slightly distorted octahedral coordination geometries.	Cobalt(2+)	49-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-24
25084240-3	2015	All of the M(II) (Co(II) or Ni(II)) ions for the cobalt(II) or nickel(II) complexes are six-coordinated and have slightly distorted octahedral coordination geometries.	Nickel(2+)	63-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-24
25064505-1	2015	Metal complexes of the chloride, nitrate and acetate salts of Co(II), Ni(II) Cu(II), Zn(II), Cd(II) or Hg(II) with 2,3-butanedione bis(isonicotinylhydrazone) [BBINH] have been synthesized and structurally characterized.	Chlorides	23-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-68
25064505-1	2015	Metal complexes of the chloride, nitrate and acetate salts of Co(II), Ni(II) Cu(II), Zn(II), Cd(II) or Hg(II) with 2,3-butanedione bis(isonicotinylhydrazone) [BBINH] have been synthesized and structurally characterized.	Nitrates	33-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-68
25218230-1	2015	New Co(II), Ni(II) and Cu(II) complexes derived from tetradentate macrocyclic nitrogen ligand, (1E,4E,8E,12E)-5,8,13,16-tetramethyl-1,4,9,12-tetrazacyclohexadeca-4,8,12,16-tetraene (EDHDH) have been synthesized.	Nitrogen	78-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
25064505-1	2015	Metal complexes of the chloride, nitrate and acetate salts of Co(II), Ni(II) Cu(II), Zn(II), Cd(II) or Hg(II) with 2,3-butanedione bis(isonicotinylhydrazone) [BBINH] have been synthesized and structurally characterized.	Acetates	45-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-68
25064505-1	2015	Metal complexes of the chloride, nitrate and acetate salts of Co(II), Ni(II) Cu(II), Zn(II), Cd(II) or Hg(II) with 2,3-butanedione bis(isonicotinylhydrazone) [BBINH] have been synthesized and structurally characterized.	2,3-butanedione bis(isonicotinylhydrazone)	115-157	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-68
25105264-0	2015	Synthesis, antimicrobial activity, structural and spectral characterization and DFT calculations of Co(II), Ni(II), Cu(II) and Pd(II) complexes of 4-amino-5-pyrimidinecarbonitrile.	Polydioxanone	127-133	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-106
25105264-0	2015	Synthesis, antimicrobial activity, structural and spectral characterization and DFT calculations of Co(II), Ni(II), Cu(II) and Pd(II) complexes of 4-amino-5-pyrimidinecarbonitrile.	4-amino-5-pyrimidinecarbonitrile	147-179	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-106
25218230-1	2015	New Co(II), Ni(II) and Cu(II) complexes derived from tetradentate macrocyclic nitrogen ligand, (1E,4E,8E,12E)-5,8,13,16-tetramethyl-1,4,9,12-tetrazacyclohexadeca-4,8,12,16-tetraene (EDHDH) have been synthesized.	(1e,4e,8e,12e)-5,8,13,16-tetramethyl-1,4,9,12-tetrazacyclohexadeca-4,8,12,16-tetraene	95-180	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
25105264-1	2015	Co(II), Ni(II), Cu(II) and Pd(II) complexes of 4-amino-5-pyrimidinecarbonitrile (APC) have been synthesized and characterized using elemental analysis, magnetic susceptibility, mass spectrometry, infrared (4000-200 cm(-1)), UV-Visible (200-1100 nm), (1)H NMR and ESR spectroscopy as well as TGA analysis.	4-amino-5-pyrimidinecarbonitrile	47-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
25064505-7	2015	In [Co2(BBINH)(H2O)Cl3]Cl H2O, BBINH has the same dentate but with the two Co(II) ions.	2,3-butanedione bis(isonicotinylhydrazone)	8-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-81
25064507-1	2015	A new chelating agent, N"-(4-methoxybenzylidene)-2-oxo-2-(phenylamino)acetohydrazide (H2OMPH) and its complexes with Mn(II), Co(II), Ni(II), Cu(II), Zn(II), Hg(II) and U(IV)O2(2+) ions have been prepared and characterized by conventional techniques.	n"-(4-methoxybenzylidene)-2-oxo-2-(phenylamino)acetohydrazide	23-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-131
25218230-1	2015	New Co(II), Ni(II) and Cu(II) complexes derived from tetradentate macrocyclic nitrogen ligand, (1E,4E,8E,12E)-5,8,13,16-tetramethyl-1,4,9,12-tetrazacyclohexadeca-4,8,12,16-tetraene (EDHDH) have been synthesized.	edhdh	182-187	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
25064507-1	2015	A new chelating agent, N"-(4-methoxybenzylidene)-2-oxo-2-(phenylamino)acetohydrazide (H2OMPH) and its complexes with Mn(II), Co(II), Ni(II), Cu(II), Zn(II), Hg(II) and U(IV)O2(2+) ions have been prepared and characterized by conventional techniques.	h2omph	86-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-131
25105264-3	2015	The infrared spectra of Co(II), Ni(II) and Cu(II) complexes indicate a bidentate type of bonding for APC through the exocyclic amino and adjacent pyrimidine nitrogen as donors whereas APC coordinated to Pd(II) ion as a monodentated ligand via a pyrimidine nitrogen donor.	pyrimidine	146-156	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-30
25105264-3	2015	The infrared spectra of Co(II), Ni(II) and Cu(II) complexes indicate a bidentate type of bonding for APC through the exocyclic amino and adjacent pyrimidine nitrogen as donors whereas APC coordinated to Pd(II) ion as a monodentated ligand via a pyrimidine nitrogen donor.	Nitrogen	157-165	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-30
25105264-3	2015	The infrared spectra of Co(II), Ni(II) and Cu(II) complexes indicate a bidentate type of bonding for APC through the exocyclic amino and adjacent pyrimidine nitrogen as donors whereas APC coordinated to Pd(II) ion as a monodentated ligand via a pyrimidine nitrogen donor.	Polydioxanone	203-209	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-30
25105264-3	2015	The infrared spectra of Co(II), Ni(II) and Cu(II) complexes indicate a bidentate type of bonding for APC through the exocyclic amino and adjacent pyrimidine nitrogen as donors whereas APC coordinated to Pd(II) ion as a monodentated ligand via a pyrimidine nitrogen donor.	pyrimidine	245-255	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-30
25218230-3	2015	The complexes afforded the formulae: [Cu(EDHDH)Cl2] 2EtOH and [M(EDHDH)X2] nH2O where M=Co(II) and Ni(II), X=Cl(-) or OH(-), n=1,0, respectively.	[m(edhdh)x2	62-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-94
25105264-3	2015	The infrared spectra of Co(II), Ni(II) and Cu(II) complexes indicate a bidentate type of bonding for APC through the exocyclic amino and adjacent pyrimidine nitrogen as donors whereas APC coordinated to Pd(II) ion as a monodentated ligand via a pyrimidine nitrogen donor.	Nitrogen	256-264	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-30
25531180-2	2015	The list of metal ions studied here includes Zn(II), Cd(II), Ni(II), Co(II), and Cu(I).	Metals	12-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-74
25124845-1	2015	A new series of complexes of Ni(II), Co(II), Cu(II), Cd(II), Mn(II), Hg(II) and UO2(2+) derived from 2-acetylpyridine-alpha-naphthoxyacetylhydrazone (HA2PNA) have been prepared and characterized by elemental analyses, spectral (IR, UV-visible, ESR and (1)H NMR) as well as magnetic and thermal measurements.	2-acetylpyridine-alpha-naphthoxyacetylhydrazone	101-148	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-43
25620445-4	2015	To identify the immunomodulatory factors stimulated through 5-aza treatment, we investigated the changes in promoter methylation patterns using methylation arrays and observed that the promoters of immunomodulatory factors, COX2 and PTGES, and migration-related factors, CXCR2 and CXCR4, were hypomethylated after 5-aza treatment.	Azacitidine	60-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	224-228
25620445-5	2015	In addition, we observed that the COX2-PGE2 pathway is one of the main pathways for the enhanced immunosuppressive activity of hMSCs through 5-aza treatment.	Dinoprostone	39-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-38
25620445-5	2015	In addition, we observed that the COX2-PGE2 pathway is one of the main pathways for the enhanced immunosuppressive activity of hMSCs through 5-aza treatment.	Azacitidine	141-146	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-38
25494642-1	2015	We report the synthesis of a perylene derivative (perylene tetracarboxylic di(propyl imidazole), abbreviated as PDI) that is coordinated with Co(II) ions to form a coordination polymer [PDI-Co(Cl)2(H2O)2]n (abbreviated as PDI-Co).	Perylene	29-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	142-148
25218028-0	2015	COX-2- and endoplasmic reticulum stress-independent induction of ULBP-1 and enhancement of sensitivity to NK cell-mediated cytotoxicity by celecoxib in colon cancer cells.	Celecoxib	139-148	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
25218028-2	2015	Celecoxib and its non-coxib analog, 2,5-dimethyl celecoxib, induced ULBP-1 and DR5 in both COX-2 negative HCT-15 cells and COX-2 positive HT-29 cells.	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-96
25218028-2	2015	Celecoxib and its non-coxib analog, 2,5-dimethyl celecoxib, induced ULBP-1 and DR5 in both COX-2 negative HCT-15 cells and COX-2 positive HT-29 cells.	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-128
25218028-2	2015	Celecoxib and its non-coxib analog, 2,5-dimethyl celecoxib, induced ULBP-1 and DR5 in both COX-2 negative HCT-15 cells and COX-2 positive HT-29 cells.	2,5-dimethylcelecoxib	36-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-96
25218028-2	2015	Celecoxib and its non-coxib analog, 2,5-dimethyl celecoxib, induced ULBP-1 and DR5 in both COX-2 negative HCT-15 cells and COX-2 positive HT-29 cells.	2,5-dimethylcelecoxib	36-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-128
25218028-7	2015	Taken together, these findings suggest that celecoxib induces the expression of ULBP-1 as well as DR5 in clonogenic colon cancer cells via COX-2 and ER stress-independent pathways, and increases their susceptibility to NK cells.	Celecoxib	44-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-144
25494642-1	2015	We report the synthesis of a perylene derivative (perylene tetracarboxylic di(propyl imidazole), abbreviated as PDI) that is coordinated with Co(II) ions to form a coordination polymer [PDI-Co(Cl)2(H2O)2]n (abbreviated as PDI-Co).	perylene tetracarboxylic di(propyl imidazole	50-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	142-148
25434878-0	2015	3D Co(II) coordination polymer with ferrimagnetic-like layers based on azide and tetrazolate bridges showing slow magnetic dynamics.	Azides	71-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	3-8
25434878-0	2015	3D Co(II) coordination polymer with ferrimagnetic-like layers based on azide and tetrazolate bridges showing slow magnetic dynamics.	tetrazolate	81-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	3-8
25494642-1	2015	We report the synthesis of a perylene derivative (perylene tetracarboxylic di(propyl imidazole), abbreviated as PDI) that is coordinated with Co(II) ions to form a coordination polymer [PDI-Co(Cl)2(H2O)2]n (abbreviated as PDI-Co).	co(cl)	190-196	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	142-148
25434878-1	2015	A novel 3D Co(II) coordination polymer, [Co6(4-ptz)6(N3)6]n (1) (4-ptz = 4-(pyridinyl)tetrazole), was synthesized by in situ hydrothermal reaction and characterized magnetically.	[co6(4-ptz)6(n3)6]n	40-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-16
25494642-1	2015	We report the synthesis of a perylene derivative (perylene tetracarboxylic di(propyl imidazole), abbreviated as PDI) that is coordinated with Co(II) ions to form a coordination polymer [PDI-Co(Cl)2(H2O)2]n (abbreviated as PDI-Co).	Water	198-201	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	142-148
25434878-1	2015	A novel 3D Co(II) coordination polymer, [Co6(4-ptz)6(N3)6]n (1) (4-ptz = 4-(pyridinyl)tetrazole), was synthesized by in situ hydrothermal reaction and characterized magnetically.	4-ptz	45-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-16
25494642-2	2015	The PDI-Co complex combines the photoactivity of the perylene dye with the electrocatalytic activity of the "Co(II)" center for photoelectrochemical hydrogen evolution reaction (HER).	Perylene	53-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-115
25434878-1	2015	A novel 3D Co(II) coordination polymer, [Co6(4-ptz)6(N3)6]n (1) (4-ptz = 4-(pyridinyl)tetrazole), was synthesized by in situ hydrothermal reaction and characterized magnetically.	4-(pyridinyl)tetrazole	73-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-16
25494642-2	2015	The PDI-Co complex combines the photoactivity of the perylene dye with the electrocatalytic activity of the "Co(II)" center for photoelectrochemical hydrogen evolution reaction (HER).	Hydrogen	149-157	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-115
25494642-4	2015	The composite shows good performance in multiple cycle testing and the turnover number (TON vs Co(II)) of this hybrid material for hydrogen evolution reaction (754 after 5 h) is considerably higher than previously reported dye-sensitized cobalt-based catalysts.	Hydrogen	131-139	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-101
25494642-4	2015	The composite shows good performance in multiple cycle testing and the turnover number (TON vs Co(II)) of this hybrid material for hydrogen evolution reaction (754 after 5 h) is considerably higher than previously reported dye-sensitized cobalt-based catalysts.	Cobalt	238-244	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-101
25460026-6	2015	Moreover, AM404 inhibited both the expression of COX-2 at transcriptional and post-transcriptional levels and the synthesis of PGE2.	N-(4-hydroxyphenyl)arachidonylamide	10-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-54
25407696-4	2015	The maximum sorption capacities of U(VI), Eu(III) and Co(II) on PAM/GO (0.698, 1.245 and 1.621 mmol g(-1), respectively) at pH = 5.0 +- 0.1 and T = 295 K were much higher than those of radionuclides on GO and other adsorbents.	Radioisotopes	185-198	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-60
25452446-1	2015	PURPOSE: Overexpression of COX-2 correlates with advanced stage and worse outcomes in non-small-cell lung cancer (NSCLC), possibly as a result of elevated levels of COX-2-dependent prostaglandin E2 (PGE2).	Dinoprostone	181-197	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-32
25452446-1	2015	PURPOSE: Overexpression of COX-2 correlates with advanced stage and worse outcomes in non-small-cell lung cancer (NSCLC), possibly as a result of elevated levels of COX-2-dependent prostaglandin E2 (PGE2).	Dinoprostone	181-197	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	165-170
25452446-1	2015	PURPOSE: Overexpression of COX-2 correlates with advanced stage and worse outcomes in non-small-cell lung cancer (NSCLC), possibly as a result of elevated levels of COX-2-dependent prostaglandin E2 (PGE2).	Dinoprostone	199-203	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-32
25452446-1	2015	PURPOSE: Overexpression of COX-2 correlates with advanced stage and worse outcomes in non-small-cell lung cancer (NSCLC), possibly as a result of elevated levels of COX-2-dependent prostaglandin E2 (PGE2).	Dinoprostone	199-203	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	165-170
25452446-2	2015	Exploratory analyses of studies that used COX-2 inhibitors have demonstrated potentially superior outcome in patients in whom the urinary metabolite of PGE2 (PGE-M) is suppressed.	Dinoprostone	152-156	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47
25452446-2	2015	Exploratory analyses of studies that used COX-2 inhibitors have demonstrated potentially superior outcome in patients in whom the urinary metabolite of PGE2 (PGE-M) is suppressed.	Prostaglandins E	152-155	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47
25462243-0	2015	Synthesis, molecular structure, biological properties and molecular docking studies on Mn(II), Co(II) and Zn(II) complexes containing bipyridine-azide ligands.	bipyridine-azide	134-150	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-101
25462243-2	2015	The structure of complexes (1-3) have been determined by single crystal X-ray diffraction studies and the configuration of ligand-coordinated metal(II) ion was well described as distorted octahedral coordination geometry for Mn(II), Co(II) and distorted square pyramidal geometry for Zn(II) complexes.	metal(ii)	142-151	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	233-239
25460026-8	2015	We found that Cot/Tlp-2 induced NFAT and COX-2 transcriptional activities were inhibited by AM404.	N-(4-hydroxyphenyl)arachidonylamide	92-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-46
25323059-4	2015	Virtual screening was performed by docking the designed compounds into the ATP binding site of COX-2 receptor to predict if these compounds have analogous binding mode to the COX-2 inhibitor.	Adenosine Triphosphate	75-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-100
25366592-7	2015	Currently, we propose that IA is a chronic inflammatory disease regulated by a positive feedback loop consisting of the cyclooxygenase (COX)-2 - prostaglandin (PG) E2 - prostaglandin E receptor 2 (EP2) - nuclear factor (NF)-kappaB signaling pathway triggered under hemodynamic stress and macrophage infiltration via NF-kappaB-mediated monocyte chemoattractant protein (MCP)-1 induction.	prostaglandin (pg	145-162	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-142
25590316-9	2015	PGE2 concentrations are reduced in AERD, and our published studies confirm that this reflects diminished expression of cyclooxygenase (COX)-2.	Dinoprostone	0-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-141
25409926-4	2015	We explored whether luteolin, a common flavonoid in many types of plants, may inhibit interleukin (IL)-1beta function induction of the inflammation biomarker cyclooxygenase (COX)-2.	Luteolin	20-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	158-180
26609524-7	2015	When BMP9 and miR-548d-5p were combined, more potent effects on both COX-2 and PPARgamma were observed than BMP9 or miR-548d-5p alone.	mir-548d-5p	14-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-74
26074738-1	2015	Co(II), Ni(II), Cu(II), and Zn(II) complexes of (4E)-4-[(2-{(E)-[1-(2,4-dihydroxyphenyl)ethylidene]amino}ethyl)imino]pentan-2-one have been synthesized and characterized by elemental analyses, molar conductance, electronic and IR spectral studies, and XRD.	(4e)-4-[(2-{(e)-[1-(2,4-dihydroxyphenyl)ethylidene]amino}ethyl)imino]pentan-2-one	48-129	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
26074738-3	2015	Tetrahedral geometry is proposed for Co(II) complex and square-planar geometry for Ni(II) and Cu(II) complexes.	Nickel(2+)	83-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-43
26074738-3	2015	Tetrahedral geometry is proposed for Co(II) complex and square-planar geometry for Ni(II) and Cu(II) complexes.	cu(ii)	94-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-43
26074738-5	2015	The antioxidant activity by DPPH and ABTS method was examined and it shows Cu(II); IC50 = 2.31 +- 1.54 microM for DPPH and Co(II); IC50 = 1.83 +- 1.08 microM for ABTS were the most active.	1,1-diphenyl-2-picrylhydrazyl	28-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-129
26074738-5	2015	The antioxidant activity by DPPH and ABTS method was examined and it shows Cu(II); IC50 = 2.31 +- 1.54 microM for DPPH and Co(II); IC50 = 1.83 +- 1.08 microM for ABTS were the most active.	2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid	37-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-129
26074738-5	2015	The antioxidant activity by DPPH and ABTS method was examined and it shows Cu(II); IC50 = 2.31 +- 1.54 microM for DPPH and Co(II); IC50 = 1.83 +- 1.08 microM for ABTS were the most active.	cu(ii)	75-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-129
26074738-5	2015	The antioxidant activity by DPPH and ABTS method was examined and it shows Cu(II); IC50 = 2.31 +- 1.54 microM for DPPH and Co(II); IC50 = 1.83 +- 1.08 microM for ABTS were the most active.	2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid	162-166	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-129
26609524-7	2015	When BMP9 and miR-548d-5p were combined, more potent effects on both COX-2 and PPARgamma were observed than BMP9 or miR-548d-5p alone.	mir-548d-5p	116-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-74
25385481-1	2015	Hierarchically superstructured Prussian blue analogues (hexacyanoferrate, M=Ni(II) , Co(II) and Cu(II) ) are synthesized through a spontaneous assembly technique.	ferric ferrocyanide	31-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-91
26584288-7	2015	RESULTS: The different concentrations of ginsenoside Rg1 that were added to the basic chondrogenic inductive culture medium promoted the proliferation of HBASCs at earlier stages (groups B, C, and D) but resulted in chondrogenic phenotype differentiation and higher mRNA expression of collagen type II (CO-II), collagen type XI (CO-XI), acid phosphatase (ACP), cartilage oligomeric matrix protein (COMP) and ELASTIN compared with the control (group A) at later stages.	Ginsenosides	41-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	285-301
26584288-7	2015	RESULTS: The different concentrations of ginsenoside Rg1 that were added to the basic chondrogenic inductive culture medium promoted the proliferation of HBASCs at earlier stages (groups B, C, and D) but resulted in chondrogenic phenotype differentiation and higher mRNA expression of collagen type II (CO-II), collagen type XI (CO-XI), acid phosphatase (ACP), cartilage oligomeric matrix protein (COMP) and ELASTIN compared with the control (group A) at later stages.	Ginsenosides	41-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	303-308
25773949-8	2015	CONCLUSIONS: Since this transcription factor is controlled by the altered expression of COX-2, the inhibition of this enzyme by ketoprofen may represent a significant step in synergistic cascade of the therapy and prevention of colon and cervical cancer (Tab.	Ketoprofen	128-138	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-93
25701047-7	2015	These discrete responses at the single-cell resolution were correlated with PGE2 secretion and were ablated by shRNA-mediated knockdown of COX-2.	Dinoprostone	76-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-144
25701047-10	2015	To our knowledge this is the first report linking the expression of COX-2 with mechanotransduction of human breast cancer cells, and the regulation of COX-2-PGE2-EP signaling with physical properties of the tumor microenvironment.	Dinoprostone	157-161	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-156
25967073-8	2015	Walls of ruptured human intracranial aneurysms have higher levels of COX-2 and microsomal prostaglandin E2 synthase 1 (mPGES-1), both of which are known to be inhibited by aspirin.	Aspirin	172-179	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-74
25967073-9	2015	In a pilot study, patients undergoing microsurgical clipping had attenuated expression of COX-2, mPGES-1, and macrophages in aneurysm walls after 3 months of aspirin therapy versus those that did not receive aspirin.	Aspirin	158-165	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-95
25967073-11	2015	Treatment with aspirin also resulted in decreased expression of COX-2 within leukocytes within aneurysms as compared to peripheral blood samples.	Aspirin	15-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-69
26002457-3	2015	By examining the recent literature on the effect of the anti-inflammatory prostaglandins 15d-PGJ2 and Delta12-PGJ2, we propose that new therapeutic agents for this disease could facilitate the transition from the COX-2-dependent pro-inflammatory synthesis of the prostaglandin PGE2 (catalyzed by mPGES-1), to the equally COX-2-dependent synthesis of the aforementioned anti-inflammatory prostaglandins.	prostaglandins 15d-pgj2	74-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	213-218
25097102-0	2015	Pharmacokinetic, pharmacodynamic, and safety/tolerability profiles of CG100649, a novel COX-2 inhibitor: results of a phase i, randomized, multiple-dose study in healthy Korean men and women.	CG100649	70-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-93
26521945-4	2015	Beneficial effect of COX-2 inhibitor celecoxib add-on therapy has been reported in early stage of schizophrenia.	Celecoxib	37-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-26
26369678-3	2015	Epidemiological, clinical, and observational studies have demonstrated that aspirin and non-steroidal antiinflammatory drugs (NSAIDs), including COX-2 inhibitors, can protect against CRC and significantly reduce its incidence.	Aspirin	76-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-150
25636958-7	2015	The effects of BM567 on mRNA expression of cyclooxygenase (COX)-2, a downstream product of NF-kappaB2 and an upstream enzyme of TxA2, was examined by real-time quantitative PCR experiments.	BM 567	15-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-65
25434759-5	2015	The expression levels of iNOS, COX-2, and NF-kappaB were also suppressed by treatment with calcium citrate.	Calcium Citrate	91-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-36
26495958-8	2015	In contrast, in normal HBE-1 cells, fully sulfated heparin significantly suppressed only ERK signaling, COX-2 gene expression at 12 hours, and CXCL-8 gene expression at 6 and 12 hours, while desulfated heparin had no significant effects on LPS-stimulated signaling or on gene or protein expression.	Heparin	51-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
26566186-8	2015	Among the described compounds, selenium-containing coxibs inhibiting COX-2 and Akt, in addition to the multi-target biphenyl derivatives as dual inhibitors of COX and fatty acid amide hydrolase, are the most promising ones.	Selenium	31-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-74
26408159-1	2015	The endocannabinoids anandamide and 2-arachidonoylglycerol are metabolised by both hydrolytic enzymes (primarily fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MGL)) and oxygenating enzymes (e.g. cyclooxygenase-2, COX-2).	Endocannabinoids	4-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	230-235
26408159-1	2015	The endocannabinoids anandamide and 2-arachidonoylglycerol are metabolised by both hydrolytic enzymes (primarily fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MGL)) and oxygenating enzymes (e.g. cyclooxygenase-2, COX-2).	anandamide	21-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	230-235
26408159-1	2015	The endocannabinoids anandamide and 2-arachidonoylglycerol are metabolised by both hydrolytic enzymes (primarily fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MGL)) and oxygenating enzymes (e.g. cyclooxygenase-2, COX-2).	glyceryl 2-arachidonate	36-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	230-235
24620015-10	2015	BMI, BP and lipid profile, the potential CV risk factors, showed significant impairment in a selective COX-2-I group: p&lt;0.01, p&lt;0.001 and p&lt;0.05, respectively, vs. baseline and p&lt;0.05 for BMI and triglycerides vs. nonselective COX-Is.	Triglycerides	208-221	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-108
25176057-8	2015	Furthermore, Western blot assay and immunohistochemistry results showed that DHGA-D pre-treatment significantly inhibits UVB-induced COX-2 expression in vivo.	dehydroglyasperin D	77-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	133-138
25676325-2	2015	NSAIDs are known as targets of cyclooxygenase enzyme (COX-1, COX-2 and COX-3) in arachidonic acid metabolism.	Arachidonic Acid	81-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-66
25463020-1	2015	The cyclooxygenases (COX-1 and COX-2) catalyze the rate-limiting step in the biosynthesis of prostaglandins, and are the pharmacological targets of non-steroidal anti-inflammatory drugs (NSAIDs) and COX-2 selective inhibitors (coxibs).	Prostaglandins	93-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-36
25463020-1	2015	The cyclooxygenases (COX-1 and COX-2) catalyze the rate-limiting step in the biosynthesis of prostaglandins, and are the pharmacological targets of non-steroidal anti-inflammatory drugs (NSAIDs) and COX-2 selective inhibitors (coxibs).	Prostaglandins	93-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	199-204
25463020-6	2015	Our structure reveals that only the S-isomer of IBP was bound, indicating that the S-isomer possesses higher affinity for COX-2 than the R-isomer.	Ibuprofen	48-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-127
25463020-7	2015	Mutational analysis of Arg-120 and Tyr-355 at the entrance of the cyclooxygenase channel confirmed their role in binding and inhibition of COX-2 by IBP.	Arginine	23-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-144
25463020-7	2015	Mutational analysis of Arg-120 and Tyr-355 at the entrance of the cyclooxygenase channel confirmed their role in binding and inhibition of COX-2 by IBP.	Tyrosine	35-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-144
25463020-7	2015	Mutational analysis of Arg-120 and Tyr-355 at the entrance of the cyclooxygenase channel confirmed their role in binding and inhibition of COX-2 by IBP.	Ibuprofen	148-151	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-144
25433956-3	2015	Thus, the question arises, how NSAIDs do exert their damaging effects especially in the lower GI tract and how to explain the reduced risk of a COX-2 selective inhibitor, celecoxib.	Celecoxib	171-180	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	144-149
25575814-5	2015	Association of phospho-PHBT258 with MEKK1 but not MEKK3 activates IKK/IkappaB/NF-kappaB and MEK/ERK to increase cellular COX-2/PGE2 and an E-cadherin suppressor Snail leading to enhancement of epithelial-mesenchymal transition (EMT) and lung cancer migration/invasion.	phospho-phbt258	15-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-126
25734181-7	2015	PGE2 is induced in the arachidonate cascade by COX-2.	Dinoprostone	0-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
25734181-7	2015	PGE2 is induced in the arachidonate cascade by COX-2.	Arachidonic Acid	23-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
25734181-8	2015	PGE2 maintains high expression of COX-2 and induces angiogenic factors including VEGF and bFGF, causing carcinogenesis.	Dinoprostone	0-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-39
26163782-1	2015	Some new complexes of Mn(II), Co(II), Ni(II), Cu(II), Zn(II), and Fe(III) with the Schiff base 5-chloro-2-(furan-2-yl methylamino)phenyl)phenyl methanone has been synthesized and characterized by elemental analysis, spectroscopic data including FT-IR, (1)H NMR, Electronic, ESI mass, Mossbauer &amp; ESR.	Zinc	54-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-36
26163782-1	2015	Some new complexes of Mn(II), Co(II), Ni(II), Cu(II), Zn(II), and Fe(III) with the Schiff base 5-chloro-2-(furan-2-yl methylamino)phenyl)phenyl methanone has been synthesized and characterized by elemental analysis, spectroscopic data including FT-IR, (1)H NMR, Electronic, ESI mass, Mossbauer &amp; ESR.	Schiff Bases	83-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-36
26163782-1	2015	Some new complexes of Mn(II), Co(II), Ni(II), Cu(II), Zn(II), and Fe(III) with the Schiff base 5-chloro-2-(furan-2-yl methylamino)phenyl)phenyl methanone has been synthesized and characterized by elemental analysis, spectroscopic data including FT-IR, (1)H NMR, Electronic, ESI mass, Mossbauer &amp; ESR.	5-chloro-2-(furan-2-yl methylamino)phenyl)phenyl methanone	95-153	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-36
26163782-1	2015	Some new complexes of Mn(II), Co(II), Ni(II), Cu(II), Zn(II), and Fe(III) with the Schiff base 5-chloro-2-(furan-2-yl methylamino)phenyl)phenyl methanone has been synthesized and characterized by elemental analysis, spectroscopic data including FT-IR, (1)H NMR, Electronic, ESI mass, Mossbauer &amp; ESR.	Adenosine Monophosphate	295-298	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-36
26163782-6	2015	The antitumor activity of Co(II) complex was tested by MTT assay.	monooxyethylene trimethylolpropane tristearate	55-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-32
26163785-1	2015	Mononuclear transition metal complexes of Mn(II), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) with a new hydrazone ligand derived from pyrazine-2-carbohydrazide and 2-hydroxyacetophenone have been synthesized.	Metals	23-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-56
26163785-1	2015	Mononuclear transition metal complexes of Mn(II), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) with a new hydrazone ligand derived from pyrazine-2-carbohydrazide and 2-hydroxyacetophenone have been synthesized.	Hydrazones	103-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-56
26163785-1	2015	Mononuclear transition metal complexes of Mn(II), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) with a new hydrazone ligand derived from pyrazine-2-carbohydrazide and 2-hydroxyacetophenone have been synthesized.	pyrazine-2-carbohydrazide	133-158	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-56
26163785-6	2015	The Mn(II), Co(II), Ni(II) and Cu(II) complexes have been assigned a monomeric octahedral geometry whereas tetrahedral to Zn(II) and Cd(II) complexes.	Zinc	122-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-18
26163785-6	2015	The Mn(II), Co(II), Ni(II) and Cu(II) complexes have been assigned a monomeric octahedral geometry whereas tetrahedral to Zn(II) and Cd(II) complexes.	cd(ii)	133-139	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-18
25531650-0	2014	Olmesartan decreased levels of IL-1beta and TNF-alpha, down-regulated MMP-2, MMP-9, COX-2, RANK/RANKL and up-regulated SOCs-1 in an intestinal mucositis model.	olmesartan	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-89
25139172-4	2015	In general terms, non-flavonoid polyphenols reduce the production of inflammatory mediators, such as IL-1beta, IL-8, MCP-1, COX-2 or iNOS in these animal models of diabetes.	Flavonoids	22-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	124-129
25139172-4	2015	In general terms, non-flavonoid polyphenols reduce the production of inflammatory mediators, such as IL-1beta, IL-8, MCP-1, COX-2 or iNOS in these animal models of diabetes.	Polyphenols	32-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	124-129
26002457-3	2015	By examining the recent literature on the effect of the anti-inflammatory prostaglandins 15d-PGJ2 and Delta12-PGJ2, we propose that new therapeutic agents for this disease could facilitate the transition from the COX-2-dependent pro-inflammatory synthesis of the prostaglandin PGE2 (catalyzed by mPGES-1), to the equally COX-2-dependent synthesis of the aforementioned anti-inflammatory prostaglandins.	Prostaglandins	74-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	321-326
26002457-3	2015	By examining the recent literature on the effect of the anti-inflammatory prostaglandins 15d-PGJ2 and Delta12-PGJ2, we propose that new therapeutic agents for this disease could facilitate the transition from the COX-2-dependent pro-inflammatory synthesis of the prostaglandin PGE2 (catalyzed by mPGES-1), to the equally COX-2-dependent synthesis of the aforementioned anti-inflammatory prostaglandins.	Dinoprostone	277-281	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	213-218
26002457-3	2015	By examining the recent literature on the effect of the anti-inflammatory prostaglandins 15d-PGJ2 and Delta12-PGJ2, we propose that new therapeutic agents for this disease could facilitate the transition from the COX-2-dependent pro-inflammatory synthesis of the prostaglandin PGE2 (catalyzed by mPGES-1), to the equally COX-2-dependent synthesis of the aforementioned anti-inflammatory prostaglandins.	Prostaglandins	74-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	213-218
26002457-3	2015	By examining the recent literature on the effect of the anti-inflammatory prostaglandins 15d-PGJ2 and Delta12-PGJ2, we propose that new therapeutic agents for this disease could facilitate the transition from the COX-2-dependent pro-inflammatory synthesis of the prostaglandin PGE2 (catalyzed by mPGES-1), to the equally COX-2-dependent synthesis of the aforementioned anti-inflammatory prostaglandins.	Prostaglandins	74-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	321-326
26004413-4	2015	However, numerous studies have now shown that the cancer chemopreventive properties of ibuprofen are much more complex and likely involve multiple COX-2-independent effects.	Ibuprofen	87-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-152
25872333-2	2015	MATERIALS AND METHODS: Double-stranded DNA oligonucleotide of COX-2-shRNA was designed and synthesized, and the recombinant lentiviral vector COX-2-ShRNA (LV-COX-2-ShRNA) was constructed.	Oligonucleotides	43-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
26495958-0	2015	Heparin and LPS-induced COX-2 expression in airway cells: a link between its anti-inflammatory effects and GAG sulfation.	Glycosaminoglycans	107-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
26495958-6	2015	In H292 cells, fully-sulfated HMW heparin significantly reduced LPS-induced gene expression of both COX-2 and CXCL-8 for up to 48 hours, while desulfated heparin had little to no significant suppressive effect on signaling or on COX-2 gene or protein expression.	Heparin	34-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-105
26495958-6	2015	In H292 cells, fully-sulfated HMW heparin significantly reduced LPS-induced gene expression of both COX-2 and CXCL-8 for up to 48 hours, while desulfated heparin had little to no significant suppressive effect on signaling or on COX-2 gene or protein expression.	Heparin	34-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	229-234
26400662-9	2015	A more accentuated evolution occurs under continuous irradiation, where Electron Paramagnetic Resonance (EPR) spectroscopy reveals the formation of Co(ii) intermediates, likely contributing to the catalytic process that evolves oxygen.	Oxygen	228-234	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	148-154
25823424-7	2015	FK-3000 suppressed NF-kappaB nuclear translocation, decreased NF-kappaB phosphorylation, and decreased COX-2 protein expression.	FK3000	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-108
25490374-2	2015	Subsequently metal complexes of the type [MLX2] and [CuL]X2; (M=Mn(II), Co(II), Ni(II) and Zn(II); X=Cl or NO3) were synthesized by the reaction of the free macrocyclic ligand (L) with the corresponding metal salts in 1:1 molar ratio.	Metals	13-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-78
25134430-0	2015	Synthesis and evaluation of benzimidazole derivatives as selective COX-2 inhibitors.	benzimidazole	28-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-72
25487445-0	2015	Hypoxia promotes 786-O cells invasiveness and resistance to sorafenib via HIF-2alpha/COX-2.	Sorafenib	60-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-90
25487445-9	2015	In conclusion, our results demonstrated that hypoxia promoted the invasiveness and resistance of 786-O cells to sorafenib via HIF2 and COX-2 and induced the activation of Snail/E-cadherin, suggesting that a signalling mechanism involving HIF2/COX2 modulates invasiveness and resistance to sorafenib in 786-O cells under hypoxia.	Sorafenib	112-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-140
25729216-1	2015	COX-2/mPGES-1/PGE2 cascade plays critical roles in modulating many physiological and pathological actions in different organs.	Dinoprostone	14-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
25729216-5	2015	The new insights from this review not only increase the understanding of the pathological role of the COX-2/mPGES-1/PGE2 pathway in kidney injuries, but also shed new light on the innovation of the strategies for the treatment of kidney diseases.	Dinoprostone	116-120	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-107
25620812-8	2015	Graphical AbstractThis study describes the facile synthesis of micro-nano Cu-Co by one-step electrodeposition of Cu(II) and Co(II) on gold electrode.	cu-co	74-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	124-130
25575814-9	2015	Phospho-PHBT258 and MIG-7 may thus play complementary roles in the initiation and sustainment of the effects of growth factors and COX-2/PGE2 on cancer invasion/metastasis.	phbt258	8-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-136
25575814-9	2015	Phospho-PHBT258 and MIG-7 may thus play complementary roles in the initiation and sustainment of the effects of growth factors and COX-2/PGE2 on cancer invasion/metastasis.	Dinoprostone	137-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-136
25666703-3	2015	NSAIDs inhibit cyclooxygenase (COX) activity resulting in the suppression of mucosal generation of gastroprotective prostaglandins (PGs) derived from a constitutive isoform, COX-1, as well as an inducible isoform, COX-2.	Prostaglandins	116-130	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	214-219
25666703-3	2015	NSAIDs inhibit cyclooxygenase (COX) activity resulting in the suppression of mucosal generation of gastroprotective prostaglandins (PGs) derived from a constitutive isoform, COX-1, as well as an inducible isoform, COX-2.	Prostaglandins	132-135	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	214-219
25666703-4	2015	COX-1-derived PGs are responsible for gastroprotection, while PGs generated via COX-2 activity also play an important role in gastroprotection and ulcer healing.	Prostaglandins	62-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-85
25666703-6	2015	In contrast to native NSAIDs, their NO-releasing derivatives such as NO-ASA were found to exhibit lower gastric toxicity despite inhibiting both COX-1 and COX-2 activity in the gastric mucosa.	Aspirin	72-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	155-160
26023055-1	2015	Schiff base complexes of Co(II), Ni(II) and Cu(II) with (E)-3-(2-benzylidenehydrazinyl)-3-oxo-N-(p-tolyl)propanamide (H2BHAH) containing N and O donor sites were synthesized.	Schiff Bases	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-31
26023055-1	2015	Schiff base complexes of Co(II), Ni(II) and Cu(II) with (E)-3-(2-benzylidenehydrazinyl)-3-oxo-N-(p-tolyl)propanamide (H2BHAH) containing N and O donor sites were synthesized.	cu(ii)	44-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-31
26023055-1	2015	Schiff base complexes of Co(II), Ni(II) and Cu(II) with (E)-3-(2-benzylidenehydrazinyl)-3-oxo-N-(p-tolyl)propanamide (H2BHAH) containing N and O donor sites were synthesized.	(e)-3-(2-benzylidenehydrazinyl)-3-oxo-n-(p-tolyl)propanamide	56-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-31
26023055-1	2015	Schiff base complexes of Co(II), Ni(II) and Cu(II) with (E)-3-(2-benzylidenehydrazinyl)-3-oxo-N-(p-tolyl)propanamide (H2BHAH) containing N and O donor sites were synthesized.	h2bhah	118-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-31
25654274-2	2015	In mammalian cells, prostaglandins are produced from arachidonic acid (AA) via cyclooxygenases (COX1 and COX2).	Prostaglandins	20-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-109
25654274-2	2015	In mammalian cells, prostaglandins are produced from arachidonic acid (AA) via cyclooxygenases (COX1 and COX2).	Arachidonic Acid	53-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-109
25263922-6	2014	The Fe3O4@CD MNPs exhibit favorable removal performance toward Co(II) and 1-naphthol from the simulated effluent.	ferryl iron	4-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-69
25407218-0	2014	Water oxidation catalysis by Co(II) impurities in Co(III)4O4 cubanes.	Water	0-5	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-35
25407218-0	2014	Water oxidation catalysis by Co(II) impurities in Co(III)4O4 cubanes.	co(iii)4o4	50-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-35
25407218-1	2014	The observed water oxidation activity of the compound class Co4O4(OAc)4(Py-X)4 emanates from a Co(II) impurity.	Water	13-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-101
25407218-1	2014	The observed water oxidation activity of the compound class Co4O4(OAc)4(Py-X)4 emanates from a Co(II) impurity.	co4o4(oac)4(py-x)4	60-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-101
25407218-3	2014	We present results from electron paramagnetic resonance spectroscopy, nuclear magnetic resonance line broadening analysis, and electrochemical titrations to establish the existence of the Co(II) impurity as the major source of water oxidation activity that has been reported for Co4O4 molecular cubanes.	Water	227-232	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	188-194
25407218-3	2014	We present results from electron paramagnetic resonance spectroscopy, nuclear magnetic resonance line broadening analysis, and electrochemical titrations to establish the existence of the Co(II) impurity as the major source of water oxidation activity that has been reported for Co4O4 molecular cubanes.	co4o4	279-284	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	188-194
25467164-0	2014	Inhibition of FAAH, TRPV1, and COX2 by NSAID-serotonin conjugates.	Serotonin	45-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-35
25467164-2	2014	The resulting NSAID-serotonin conjugates were tested in vitro for their ability to inhibit FAAH, TRPV1, and COX2.	Serotonin	20-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-112
25467164-3	2014	Ibuprofen-5-HT and Flurbiprofen-5-HT inhibited all three targets with approximately the same potency as N-arachidonoyl serotonin (AA-5-HT), while Fenoprofen-5-HT and Naproxen-5-HT showed activity as dual inhibitors of TRPV1 and COX2.	Flurbiprofen	19-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	228-232
25511800-11	2014	In multivariate analysis COX-2 expression retained its significance independent of established prognostic factors for shorter DFS (P &lt; 0.001, HR = 2.767, 95% CI = 1.563-4.901) and for inferior MFS (P = 0.002, HR = 2.7, 95% CI = 1.469-5.263) but not for OS (P = 0.096, HR = 1.929, 95% CI = 0.889-4.187).	Osmium	256-258	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-30
25423999-5	2014	The carboxylate groups of benzoate anions are coordinated to Co(II) ions in a strong bridging mode, which is the driving force for the anisotropic growth of nanofibers.	carboxylate	4-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-67
25423999-5	2014	The carboxylate groups of benzoate anions are coordinated to Co(II) ions in a strong bridging mode, which is the driving force for the anisotropic growth of nanofibers.	Benzoates	26-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-67
25423999-6	2014	When NaOH is added during the synthesis, green irregular shaped platelets are obtained, in which the carboxylate groups of benzoate anions are coordinated to the Co(II) ions in a unidentate fashion.	Sodium Hydroxide	5-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	162-168
25423999-6	2014	When NaOH is added during the synthesis, green irregular shaped platelets are obtained, in which the carboxylate groups of benzoate anions are coordinated to the Co(II) ions in a unidentate fashion.	carboxylate	101-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	162-168
25423999-6	2014	When NaOH is added during the synthesis, green irregular shaped platelets are obtained, in which the carboxylate groups of benzoate anions are coordinated to the Co(II) ions in a unidentate fashion.	Benzoates	123-131	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	162-168
25423999-7	2014	Interestingly, the nanofibers exhibit a reversible transformation of the coordination geometry of the Co(II) ions between octahedral and pseudotetrahedral with a concomitant color change between pink and blue, which involves the loss and reuptake of unusual weakly coordinated water molecules without destroying the structure.	Water	277-282	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-108
25472020-1	2014	Five novel metal organic frameworks were obtained by hydro-solvothermal reactions using the hexafluorisopropylidenebis(benzoic) acid (H2hfipbb) as linker and Co(II) or Mn(II) ions as connectors.	Metals	11-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	158-164
25494948-4	2014	Here, gamma-cyclodextrin was used to template magnetic Co(II) and nonmagnetic auxiliary Li(+) ions to form a heterometallic {Co, Li, Li}4 ring.	gamma-cyclodextrin	6-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-61
25494948-5	2014	In the sandwich-type complex [(gamma-CD)2Co4Li8(H2O)12] spatially separated Co(II) ions are prevented from superexchange magnetic coupling.	(gamma-cd)2co4li8(h2o)12	30-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-82
25318637-0	2014	A Co(II) thiocyanato coordination polymer with 4-(3-phenylpropyl)pyridine: the influence of the co-ligand on the magnetic properties.	(4-(3-phenylpropyl)pyridine)	47-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	2-8
26002457-3	2015	By examining the recent literature on the effect of the anti-inflammatory prostaglandins 15d-PGJ2 and Delta12-PGJ2, we propose that new therapeutic agents for this disease could facilitate the transition from the COX-2-dependent pro-inflammatory synthesis of the prostaglandin PGE2 (catalyzed by mPGES-1), to the equally COX-2-dependent synthesis of the aforementioned anti-inflammatory prostaglandins.	prostaglandins 15d-pgj2	74-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	321-326
26002457-3	2015	By examining the recent literature on the effect of the anti-inflammatory prostaglandins 15d-PGJ2 and Delta12-PGJ2, we propose that new therapeutic agents for this disease could facilitate the transition from the COX-2-dependent pro-inflammatory synthesis of the prostaglandin PGE2 (catalyzed by mPGES-1), to the equally COX-2-dependent synthesis of the aforementioned anti-inflammatory prostaglandins.	Prostaglandins	74-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	213-218
24960108-1	2014	A novel trinuclear Co(II) complex, {[CoL(PrOH)]2Co(H2O)} PrOH, has been synthesized with 6-ethoxy-6"-hydroxy-2,2"-[ethylenedioxybis(nitrilomethylidyne)]diphenol (H3L), and characterized by elemental analyses, FT-IR, UV-Vis, molar conductance and X-ray crystallographic analysis.	{[col(proh)]2co(h2o)} proh	35-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-25
27308371-0	2014	Improving VEGF-targeted therapies through inhibition of COX-2/PGE2 signaling.	Dinoprostone	62-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-61
27308371-2	2014	Recent studies suggest that enhanced signaling through a COX-2/PGE2 axis contributes to VEGF-independent tumor angiogenesis.	Dinoprostone	63-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-62
24960108-1	2014	A novel trinuclear Co(II) complex, {[CoL(PrOH)]2Co(H2O)} PrOH, has been synthesized with 6-ethoxy-6"-hydroxy-2,2"-[ethylenedioxybis(nitrilomethylidyne)]diphenol (H3L), and characterized by elemental analyses, FT-IR, UV-Vis, molar conductance and X-ray crystallographic analysis.	6-ethoxy-6"-hydroxy-2,2"-[ethylenedioxybis(nitrilomethylidyne)]diphenol	89-160	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-25
24960108-1	2014	A novel trinuclear Co(II) complex, {[CoL(PrOH)]2Co(H2O)} PrOH, has been synthesized with 6-ethoxy-6"-hydroxy-2,2"-[ethylenedioxybis(nitrilomethylidyne)]diphenol (H3L), and characterized by elemental analyses, FT-IR, UV-Vis, molar conductance and X-ray crystallographic analysis.	h3l	162-165	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-25
24960108-2	2014	Two n-propanol molecules and one water molecule coordinate to three Co(II) ions and four mu-phenoxo oxygen atoms from two [CoL(CH3CH2CH2OH)] units also coordinating to Co(II) ion.	1-Propanol	4-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-74
24960108-2	2014	Two n-propanol molecules and one water molecule coordinate to three Co(II) ions and four mu-phenoxo oxygen atoms from two [CoL(CH3CH2CH2OH)] units also coordinating to Co(II) ion.	1-Propanol	4-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	168-174
24960108-2	2014	Two n-propanol molecules and one water molecule coordinate to three Co(II) ions and four mu-phenoxo oxygen atoms from two [CoL(CH3CH2CH2OH)] units also coordinating to Co(II) ion.	Water	33-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-74
24960108-2	2014	Two n-propanol molecules and one water molecule coordinate to three Co(II) ions and four mu-phenoxo oxygen atoms from two [CoL(CH3CH2CH2OH)] units also coordinating to Co(II) ion.	Water	33-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	168-174
24960108-2	2014	Two n-propanol molecules and one water molecule coordinate to three Co(II) ions and four mu-phenoxo oxygen atoms from two [CoL(CH3CH2CH2OH)] units also coordinating to Co(II) ion.	mu-phenoxo	89-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	168-174
24960108-2	2014	Two n-propanol molecules and one water molecule coordinate to three Co(II) ions and four mu-phenoxo oxygen atoms from two [CoL(CH3CH2CH2OH)] units also coordinating to Co(II) ion.	Oxygen	100-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	168-174
24960108-2	2014	Two n-propanol molecules and one water molecule coordinate to three Co(II) ions and four mu-phenoxo oxygen atoms from two [CoL(CH3CH2CH2OH)] units also coordinating to Co(II) ion.	ch3ch2ch2oh	127-138	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	168-174
24960108-3	2014	All the penta-coordinated Co(II) ions of the Co(II) complex have a slightly distorted trigonal bipyramidal coordinated polyhedron.	PENTA	8-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-32
24960108-3	2014	All the penta-coordinated Co(II) ions of the Co(II) complex have a slightly distorted trigonal bipyramidal coordinated polyhedron.	PENTA	8-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-51
25303727-0	2014	Design and synthesis of benzimidazole analogs endowed with oxadiazole as selective COX-2 inhibitor.	benzimidazole	24-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
25464507-4	2014	The analytical parameters of prepared NCs were also calculated for a selective detection of divalent cobalt [Co(II)] prior to its determination by inductively coupled plasma-optical emission spectrometry (ICP-OES).	Cobalt	101-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-115
25464507-5	2014	The selectivity of NCs toward various metal ions, including Cd(II), Co(II), Cr(III), Cu(II), Fe(III), Ni(II), and Zn(II) was studied.	N-chlorosuccinimide	19-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-74
25464507-6	2014	Results of the selectivity study demonstrated that Ag2O3-ZnO NC phase was the most selective towards Co(II) ion.	ag2o3	51-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-107
25464507-6	2014	Results of the selectivity study demonstrated that Ag2O3-ZnO NC phase was the most selective towards Co(II) ion.	Zinc Oxide	57-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-107
25464507-9	2014	Kinetic study revealed that the adsorption of Co(II) on Ag2O3-ZnO NCs phase followed the pseudo-second-order kinetic model.	ag2o3	56-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-52
25464507-9	2014	Kinetic study revealed that the adsorption of Co(II) on Ag2O3-ZnO NCs phase followed the pseudo-second-order kinetic model.	Zinc Oxide	62-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-52
25464507-10	2014	In addition, thermodynamic results provided that the adsorption mechanism of Co(II) ions on Ag2O3-ZnO NCs was a spontaneous process and thermodynamically favorable.	ag2o3	92-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-83
25464507-10	2014	In addition, thermodynamic results provided that the adsorption mechanism of Co(II) ions on Ag2O3-ZnO NCs was a spontaneous process and thermodynamically favorable.	Zinc Oxide	98-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-83
25184246-0	2014	Statins enhance rotator cuff healing by stimulating the COX2/PGE2/EP4 pathway: an in vivo and in vitro study.	Dinoprostone	61-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-60
25303727-0	2014	Design and synthesis of benzimidazole analogs endowed with oxadiazole as selective COX-2 inhibitor.	Oxadiazoles	59-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
24964373-8	2014	RESULTS: The follow-up of our original case of a patient with rapid cycling who had shown impressive psychopathological improvement under celecoxib revealed complete loss of this effect upon discontinuation of the COX2 inhibitor.	Celecoxib	138-147	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	214-218
25453792-10	2014	At the concentration of 0.25 muM, the amine also inhibited both COX-1 and COX-2 enzymes by 51% and 25% (P &lt; 0.05), respectively.	Amines	38-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
25091578-7	2014	KEY RESULTS: Simvastatin was shown to activate a stress cascade, leading to the synthesis of 15-deoxy-12,14-PGJ2 (15d-PGJ2 ), in a p38- and COX-2-dependent manner.	Simvastatin	13-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-145
25091578-7	2014	KEY RESULTS: Simvastatin was shown to activate a stress cascade, leading to the synthesis of 15-deoxy-12,14-PGJ2 (15d-PGJ2 ), in a p38- and COX-2-dependent manner.	15-deoxy-12,14-pgj2	93-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-145
25091578-7	2014	KEY RESULTS: Simvastatin was shown to activate a stress cascade, leading to the synthesis of 15-deoxy-12,14-PGJ2 (15d-PGJ2 ), in a p38- and COX-2-dependent manner.	15-deoxyprostaglandin J2	114-122	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-145
25218594-6	2014	Fidarestat also decreased the expression of COX-2, iNOS, XIAP, survivin, beta-catenin and NF-kappaB in high glucose-treated HT29 colon cancer cells.	fidarestat	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-49
25186613-8	2014	Moreover, interference with COX-2 activity by indomethacin or the specific COX-2 inhibitor NS-398 also blunted the increased A549 proliferation in the presence of neutrophils.	Indomethacin	46-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
25186613-8	2014	Moreover, interference with COX-2 activity by indomethacin or the specific COX-2 inhibitor NS-398 also blunted the increased A549 proliferation in the presence of neutrophils.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	91-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
25186613-8	2014	Moreover, interference with COX-2 activity by indomethacin or the specific COX-2 inhibitor NS-398 also blunted the increased A549 proliferation in the presence of neutrophils.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	91-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
25186613-9	2014	In parallel, a massive amplification of COX-2-dependent prostaglandin E2 synthesis was detected in A549-neutrophil co-cultures.	Dinoprostone	56-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
25450471-0	2014	Selective COX-2 inhibitors suppress prostacyclin.	Epoprostenol	36-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
25261564-1	2014	Prostaglandin (PG) E2, a major product of cyclooxygenase (COX)-2, acts as an immunomodulator at the maternal-fetal interface during pregnancy.	Dinoprostone	0-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-64
25209136-7	2014	Selective cyclooxygenase (COX)-2 inhibitors, like celecoxib at usual doses, carry the lowest GI risk and are the best option in patients with moderate/high GI risk without high CV risk.	Celecoxib	50-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-32
25261564-3	2014	The activation of the COX-2/PGE2/EP signal pathway can alter the expression of the ATP-binding cassette (ABC) transporters, multidrug resistance protein 1 [P-glycoprotein (Pgp); gene: ABCB1], and breast cancer resistance protein (BCRP; gene: ABCG2), which function to extrude drugs and xenobiotics from cells.	Dinoprostone	28-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-27
25319133-0	2014	Prednisone inhibits the IL-1beta-induced expression of COX-2 in HEI-OC1 murine auditory cells through the inhibition of ERK-1/2, JNK-1 and AP-1 activity.	Prednisone	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-60
25029569-1	2014	AIM: The present meta-analysis attempted to assess whether an unfavourable cardiovascular risk profile could be identified in the case of two COX2 selective inhibitors (COXIBs), namely celecoxib and etoricoxib.	Etoricoxib	199-209	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	142-146
25319133-3	2014	In the present study, we investigated the inhibitory effects and the mechanisms of action of PDN on the expression of cyclooxygenase (COX)-2, an inflammatory enzyme involved in the production of prostaglandins (PGs), in House Ear Institute-Organ of Corti 1 (HEI-OC1) cells (a murine auditory cell line) treated with the inflammatory cytokine, interleukin (IL)-1beta.	Prostaglandins	195-209	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-140
25319133-3	2014	In the present study, we investigated the inhibitory effects and the mechanisms of action of PDN on the expression of cyclooxygenase (COX)-2, an inflammatory enzyme involved in the production of prostaglandins (PGs), in House Ear Institute-Organ of Corti 1 (HEI-OC1) cells (a murine auditory cell line) treated with the inflammatory cytokine, interleukin (IL)-1beta.	Prostaglandins	211-214	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-140
25319133-8	2014	Of note, the inhibitory effects of PDN on the IL-1beta-induced expression of COX-2 and the activation of ERK-1/2 and JNK-1 in the HEI-OC1 cells were significantly diminished by RU486, a glucocorticoid receptor (GR) antagonist, suggesting that PDN exerts its inhibitory effects through GR.	Mifepristone	177-182	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-82
25114172-5	2014	The immediate release of PGD2 from the activated MCs was solely dependent on cyclooxygenase (COX) 1, while during the delayed phase of lipid mediator production, the inducible COX-2 also contributed to its release.	Prostaglandin D2	25-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	176-181
25632479-0	2014	Selective COX-2 inhibitory properties of dihydrostilbenes from liquorice leaves--in vitro assays and structure/activity relationship study.	1,2-dihydrostilbene	41-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
25632479-4	2014	The results show that the liquorice dihydrostilbenes are preferred ligands for COX-2 rather than for COX-1, providing a good rational for the observed selectivity in ex vivo experiments.	1,2-dihydrostilbene	36-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-84
25042112-0	2014	Anti-inflammatory effects of ginsenosides Rg5 , Rz1 , and Rk1 : inhibition of TNF-alpha-induced NF-kappaB, COX-2, and iNOS transcriptional expression.	Ginsenosides	29-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-112
25042112-1	2014	In the course of this experiment on the anti-inflammatory effect of ginsenosides, protopanaxdiol ginsenosides have shown inhibition activities in inflammatory responses: NF-kappaB, COX-2, and iNOS were induced by TNF-alpha.	Ginsenosides	68-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	181-186
25042112-5	2014	Particularly, ginsenosides Rg5 , Rz1 , and Rk1 as converted ginsenosides from primary protopanaxdiol ginsenosidess significantly inhibited COX-2 and iNOS gene expression.	Ginsenosides	60-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-144
25042112-1	2014	In the course of this experiment on the anti-inflammatory effect of ginsenosides, protopanaxdiol ginsenosides have shown inhibition activities in inflammatory responses: NF-kappaB, COX-2, and iNOS were induced by TNF-alpha.	protopanaxdiol ginsenosides	82-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	181-186
25042112-5	2014	Particularly, ginsenosides Rg5 , Rz1 , and Rk1 as converted ginsenosides from primary protopanaxdiol ginsenosidess significantly inhibited COX-2 and iNOS gene expression.	protopanaxdiol ginsenosidess	86-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-144
25042112-5	2014	Particularly, ginsenosides Rg5 , Rz1 , and Rk1 as converted ginsenosides from primary protopanaxdiol ginsenosidess significantly inhibited COX-2 and iNOS gene expression.	Ginsenosides	14-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-144
25280972-8	2014	Gene expression for Cx43 and COX-2 was enhanced by tensile strain leading to increased PGE2 release and GAG levels in PAM and CAM when compared to unstrained controls.	Dinoprostone	87-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34
25280972-8	2014	Gene expression for Cx43 and COX-2 was enhanced by tensile strain leading to increased PGE2 release and GAG levels in PAM and CAM when compared to unstrained controls.	Glycosaminoglycans	104-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34
25356958-1	2014	This study examines metal binding to metallo-beta-lactamase VIM-2, demonstrating the first successful preparation of a Co(II)-substituted VIM-2 analogue.	Metals	20-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-125
25356958-2	2014	Spectroscopic studies of the half- and fully metal loaded enzymes show that both Zn(II) and Co(II) bind cooperatively, where the major species present, regardless of stoichiometry, are apo- and di-Zn (or di-Co) enzymes.	Metals	45-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-98
24576797-3	2014	Furthermore, compounds (6b, 7a and 10) showed remarkable selective inhibition of COX-2 enzyme close to that of Celecoxcib.	celecoxcib	111-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-86
25129768-9	2014	The maximum sorption capacities of sorbent in ammonium acetate buffer solution at pH 6.0 were 1.72 mmol/g for Cu(II), 1.23 mmol/g for Ag(I) and below 0.5 mmol/g for Co(II), Zn(II), Cd(II), Pb(II), Mn(II) and Ni(II) ions.	ammonium acetate	46-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	165-171
25378670-8	2014	Comparing the different COX-2 inhibitors, the HR was driven by new use of older traditional COX-2 inhibitors (1.42, 95% CI: 1.14-1.78) among which it was 1.53 (95% CI: 1.02-2.28) for etodolac and 1.28 (95% CI: 0.98-1.68) for diclofenac.	Etodolac	183-191	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
25378670-8	2014	Comparing the different COX-2 inhibitors, the HR was driven by new use of older traditional COX-2 inhibitors (1.42, 95% CI: 1.14-1.78) among which it was 1.53 (95% CI: 1.02-2.28) for etodolac and 1.28 (95% CI: 0.98-1.68) for diclofenac.	Etodolac	183-191	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-97
25378670-8	2014	Comparing the different COX-2 inhibitors, the HR was driven by new use of older traditional COX-2 inhibitors (1.42, 95% CI: 1.14-1.78) among which it was 1.53 (95% CI: 1.02-2.28) for etodolac and 1.28 (95% CI: 0.98-1.68) for diclofenac.	Diclofenac	225-235	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
25378670-8	2014	Comparing the different COX-2 inhibitors, the HR was driven by new use of older traditional COX-2 inhibitors (1.42, 95% CI: 1.14-1.78) among which it was 1.53 (95% CI: 1.02-2.28) for etodolac and 1.28 (95% CI: 0.98-1.68) for diclofenac.	Diclofenac	225-235	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-97
25200595-0	2014	Utilization of a ligand containing 2,2"-bipyridyl and tetrazolate groups to construct a 2D Co(II) coordination polymer: spin canting and metamagnetism.	2,2"-bipyridyl and tetrazolate	35-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-96
25200595-2	2014	The synthesis, X-ray crystal structure and magnetic properties of a new Co(II) coordination polymer, [Co(btzbp)]n (1), are reported.	co(btzbp)	102-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
25338262-0	2014	Synthesis and structural features of Co(II) and Co(III) complexes supported by aminotrisphenolate ligand scaffolds.	aminotrisphenolate	79-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-43
25369453-11	2014	Thus addition of AA to the culture media is skewing the DCs towards the secretion of more IL-12 and less of IL-10 along with the restoration of eicosanoids levels in a COX-2 mediated pathway thereby enhancing the functionality of these cells to be used as a potent cellular vaccine.	Eicosanoids	144-155	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	168-173
25338262-1	2014	Co(II) complexes of aminotrisphenolate ((ArO)3N(3-)) ligands can be prepared straightforwardly in high yield.	aminotrisphenolate	20-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
25338262-1	2014	Co(II) complexes of aminotrisphenolate ((ArO)3N(3-)) ligands can be prepared straightforwardly in high yield.	(aro)3n(3-))	40-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
25338262-3	2014	These Co(II) complexes can be easily converted into their Co(III) analogues in air in the presence of suitable bases such as dimethylaminopyridine and 2,2"-bipyridine, and the structural features and magnetic properties of these latter compounds are also reported.	2-Dimethylaminopyridine	125-146	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	6-12
25338262-3	2014	These Co(II) complexes can be easily converted into their Co(III) analogues in air in the presence of suitable bases such as dimethylaminopyridine and 2,2"-bipyridine, and the structural features and magnetic properties of these latter compounds are also reported.	2,2'-Dipyridyl	151-166	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	6-12
25124340-5	2014	Paracetamol, NSAIDs, COX-2 antagonists, and gabapentin reduced 24 h post-operative morphine requirements with 6.3 (95% confidence interval: 3.7 to 9.0) mg, 10.2 (8.7, 11.7) mg, 10.9 (9.1, 12.8) mg, and &gt;= 13 mg, respectively, when administered as monotherapy.	Morphine	83-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-26
25699354-8	2014	The expressional differences of the 5 informative oncogenes: EGFr, PIK3R1, PTGS2 (COX-2), PTGS1 (COX1), and ALOX5AP between SC and MC were really tiny.	Scandium	124-126	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
25037006-6	2014	Heme a3 and the CuB sites (as well as the CuA center of COX-2) are located within the channel that includes TM-6, TM-7, TM-10 and TM-11 of COX-1 and are associated with multiple cholesterol and caveolin-binding (CB) motifs.	Cholesterol	178-189	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-61
25037006-10	2014	Under physiological conditions, caveolins may introduce channel formers juxtaposed to those in COX-1, COX-2 and COX-3, which together with cholesterol may form channel(s) essential for proton translocation through the inner mitochondrial membrane.	Cholesterol	139-150	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-107
24910202-16	2014	Blocking COX2/PGE2/EP4 signaling at an earlier stage of inflammation or injury is crucial for preventing the transition from acute pain to a chronic state.	Dinoprostone	14-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	9-13
25106704-6	2014	Finally, using an HSP70 antisense strategy, we showed that the inhibitory effect of 15d-PGJ2 on IL-1-induced activation of the NF-kappaB pathway, COX-2 and mPGES-1 expression, and PGE2 synthesis was partly supported by HSP70.	15-deoxy-delta(12,14)-prostaglandin J2	84-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	146-151
25471032-3	2014	At the same time, molecular analyses revealed particular contribution of a COX-2 product - prostaglandin E2 (PGE2) - in RCC development.	Dinoprostone	91-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
25471032-3	2014	At the same time, molecular analyses revealed particular contribution of a COX-2 product - prostaglandin E2 (PGE2) - in RCC development.	Dinoprostone	109-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
25263922-0	2014	Simultaneous removal of Co(II) and 1-naphthol by core-shell structured Fe 3O4@cyclodextrin magnetic nanoparticles.	fe 3o4	71-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-30
25263922-0	2014	Simultaneous removal of Co(II) and 1-naphthol by core-shell structured Fe 3O4@cyclodextrin magnetic nanoparticles.	Cyclodextrins	78-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-30
25263922-3	2014	The removal performance of Fe3O4@CD MNPs toward Co(II) and 1-naphthol were investigated by using the batch technique.	ferryl iron	27-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-54
25263922-4	2014	The maximum sorption capacities of Fe3O4@CD MNPs toward Co(II) and 1-naphthol are higher than a series of adsorbent materials.	ferryl iron	35-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-62
25263922-5	2014	The simultaneous removal of Co(II) and 1-naphthol is achieved via the binding of Co(II) on the external surface sites of Fe3O4@CD MNPs and the incorporation of 1-naphthol into the hydrophobic cavity of surface-coated beta-CD.	1-naphthol	39-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-87
25263922-5	2014	The simultaneous removal of Co(II) and 1-naphthol is achieved via the binding of Co(II) on the external surface sites of Fe3O4@CD MNPs and the incorporation of 1-naphthol into the hydrophobic cavity of surface-coated beta-CD.	ferryl iron	121-126	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-34
25263922-5	2014	The simultaneous removal of Co(II) and 1-naphthol is achieved via the binding of Co(II) on the external surface sites of Fe3O4@CD MNPs and the incorporation of 1-naphthol into the hydrophobic cavity of surface-coated beta-CD.	ferryl iron	121-126	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-87
25263922-5	2014	The simultaneous removal of Co(II) and 1-naphthol is achieved via the binding of Co(II) on the external surface sites of Fe3O4@CD MNPs and the incorporation of 1-naphthol into the hydrophobic cavity of surface-coated beta-CD.	1-naphthol	160-170	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-34
25263922-5	2014	The simultaneous removal of Co(II) and 1-naphthol is achieved via the binding of Co(II) on the external surface sites of Fe3O4@CD MNPs and the incorporation of 1-naphthol into the hydrophobic cavity of surface-coated beta-CD.	betadex	217-224	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-34
25458048-2	2014	Parecoxib is the only parenterally administered selective cyclooxygenase (COX)-2 inhibitor widely used in acute pain control.	parecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-80
26909300-8	2014	The selective COX-2 inhibitor NS-398 inhibited PGE2 production and suppressed bone metastases with reduced osteoclastogenesis.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	30-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
25127574-1	2014	In general, the chemiluminescence (CL) sensing of vitamin B12 is achieved by determining Co(II) liberated from acidified vitamin B12 by a luminol system.	Luminol	138-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-95
25127574-3	2014	In this study, as a novel CL amplifier of the Co(II)+H2O2+OH(-) ultra-weak CL reaction (Fenton-like system), dodecylbenzene sulfonate (DBS)-layered double hydroxides (LDHs) have been applied to the specific determination of vitamin B12 by liberating Co(II).	Hydrogen Peroxide	53-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-52
25127574-3	2014	In this study, as a novel CL amplifier of the Co(II)+H2O2+OH(-) ultra-weak CL reaction (Fenton-like system), dodecylbenzene sulfonate (DBS)-layered double hydroxides (LDHs) have been applied to the specific determination of vitamin B12 by liberating Co(II).	Hydrogen Peroxide	53-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	250-256
25127574-3	2014	In this study, as a novel CL amplifier of the Co(II)+H2O2+OH(-) ultra-weak CL reaction (Fenton-like system), dodecylbenzene sulfonate (DBS)-layered double hydroxides (LDHs) have been applied to the specific determination of vitamin B12 by liberating Co(II).	DODECYL BENZENESULFONATE	109-133	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-52
25127574-3	2014	In this study, as a novel CL amplifier of the Co(II)+H2O2+OH(-) ultra-weak CL reaction (Fenton-like system), dodecylbenzene sulfonate (DBS)-layered double hydroxides (LDHs) have been applied to the specific determination of vitamin B12 by liberating Co(II).	DODECYL BENZENESULFONATE	109-133	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	250-256
25127574-3	2014	In this study, as a novel CL amplifier of the Co(II)+H2O2+OH(-) ultra-weak CL reaction (Fenton-like system), dodecylbenzene sulfonate (DBS)-layered double hydroxides (LDHs) have been applied to the specific determination of vitamin B12 by liberating Co(II).	dbs)	135-139	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-52
25127574-3	2014	In this study, as a novel CL amplifier of the Co(II)+H2O2+OH(-) ultra-weak CL reaction (Fenton-like system), dodecylbenzene sulfonate (DBS)-layered double hydroxides (LDHs) have been applied to the specific determination of vitamin B12 by liberating Co(II).	dbs)	135-139	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	250-256
25127574-3	2014	In this study, as a novel CL amplifier of the Co(II)+H2O2+OH(-) ultra-weak CL reaction (Fenton-like system), dodecylbenzene sulfonate (DBS)-layered double hydroxides (LDHs) have been applied to the specific determination of vitamin B12 by liberating Co(II).	Hydroxides	155-165	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-52
25127574-3	2014	In this study, as a novel CL amplifier of the Co(II)+H2O2+OH(-) ultra-weak CL reaction (Fenton-like system), dodecylbenzene sulfonate (DBS)-layered double hydroxides (LDHs) have been applied to the specific determination of vitamin B12 by liberating Co(II).	Hydroxides	155-165	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	250-256
26909300-8	2014	The selective COX-2 inhibitor NS-398 inhibited PGE2 production and suppressed bone metastases with reduced osteoclastogenesis.	Dinoprostone	47-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
26909300-11	2014	Our results suggest that COX2/PGE2 axis plays a critical role in the pathophysiology of osteolytic bone metastases and tumor development of the SK-NS-AS human NB.	Dinoprostone	30-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-29
25241831-4	2014	Pyrite film CEs prepared by spray pyrolysis are utilized in I3(-)/I(-) and Co(III)/Co(II) electrolyte-mediated DSSCs.	pyrite	0-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-89
25342622-0	2014	Hyaluronic acid induces COX-2 expression via CD44 in orbital fibroblasts from patients with thyroid-associated ophthalmopathy.	Hyaluronic Acid	0-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
25283436-2	2014	The design and synthesis of a novel type of Co(II) -N4 macrocyclic complex, [CoN4 ], based on the phenanthroline-indole macrocyclic ligand (PIM) is reported.	phenanthroline-indole	98-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-50
25342622-7	2014	RESULTS: Hyaluronic acid increased COX-2 expression in orbital fibroblasts from patients with TAO, which was not observed in the cells from non-TAO subjects and conjunctival or dermal fibroblasts.	Hyaluronic Acid	9-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40
25342622-9	2014	Hyaluronic acid induced MAPK and IkappaB phosphorylation; and cotreatment with specific MAPK or NF-kappaB inhibitors halted HA-induced transcription of COX-2, suggesting the involvement of these signaling pathways.	Hyaluronic Acid	0-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-157
25342622-10	2014	CONCLUSIONS: Hyaluronic acid induced COX-2 expression in orbital fibroblasts from patients with TAO via CD44 through the MAPK and NF-kappaB-mediated signaling pathways.	Hyaluronic Acid	13-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-42
25243488-1	2014	Low-temperature photolysis experiments (T = 10 K) on the tripodal azido complex [(BIMPN(Mes,Ad,Me))Co(II)(N3)] (1) were monitored by EPR spectroscopy and support the formation of an exceedingly reactive, high-valent Co nitrido species [(BIMPN(Mes,Ad,Me))Co(IV)(N)] (2).	tripodal azido	57-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-105
25177845-1	2014	In the present work we describe the synthesis, crystal structures and magnetic properties of four coordination compounds obtained by assembling a new phosphinic amide containing the TEMPO moiety, 1-piperidinyloxy-4-[(diphenylphosphinyl)amino]-2,2,6,6-tetramethyl radical (dppnTEMPO), with [M(hfac)2] building blocks (M = Cu(II), Co(II), Mn(II)).	phosphinic amide	150-166	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	329-335
25243488-1	2014	Low-temperature photolysis experiments (T = 10 K) on the tripodal azido complex [(BIMPN(Mes,Ad,Me))Co(II)(N3)] (1) were monitored by EPR spectroscopy and support the formation of an exceedingly reactive, high-valent Co nitrido species [(BIMPN(Mes,Ad,Me))Co(IV)(N)] (2).	(bimpn	81-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-105
25243488-1	2014	Low-temperature photolysis experiments (T = 10 K) on the tripodal azido complex [(BIMPN(Mes,Ad,Me))Co(II)(N3)] (1) were monitored by EPR spectroscopy and support the formation of an exceedingly reactive, high-valent Co nitrido species [(BIMPN(Mes,Ad,Me))Co(IV)(N)] (2).	2-(N-morpholino)ethanesulfonic acid	88-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-105
25243488-1	2014	Low-temperature photolysis experiments (T = 10 K) on the tripodal azido complex [(BIMPN(Mes,Ad,Me))Co(II)(N3)] (1) were monitored by EPR spectroscopy and support the formation of an exceedingly reactive, high-valent Co nitrido species [(BIMPN(Mes,Ad,Me))Co(IV)(N)] (2).	2-(N-morpholino)ethanesulfonic acid	243-246	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-105
25243488-3	2014	Although the reactivity of this species precludes handling above 50 K or isolation in the solid state, the N-migratory insertion product [(NH-BIMPN(Mes,Ad,Me))Co(II)](BPh4) (3) is isolable and was reproducibly synthesized as well as fully characterized, including CHN elemental analysis, paramagnetic (1)H NMR, IR, UV-vis, and EPR spectroscopy as well as SQUID magnetization and single-crystal X-ray crystallography studies.	(nh-bimpn	138-147	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	159-165
25243488-3	2014	Although the reactivity of this species precludes handling above 50 K or isolation in the solid state, the N-migratory insertion product [(NH-BIMPN(Mes,Ad,Me))Co(II)](BPh4) (3) is isolable and was reproducibly synthesized as well as fully characterized, including CHN elemental analysis, paramagnetic (1)H NMR, IR, UV-vis, and EPR spectroscopy as well as SQUID magnetization and single-crystal X-ray crystallography studies.	2-(N-morpholino)ethanesulfonic acid	148-151	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	159-165
25243488-3	2014	Although the reactivity of this species precludes handling above 50 K or isolation in the solid state, the N-migratory insertion product [(NH-BIMPN(Mes,Ad,Me))Co(II)](BPh4) (3) is isolable and was reproducibly synthesized as well as fully characterized, including CHN elemental analysis, paramagnetic (1)H NMR, IR, UV-vis, and EPR spectroscopy as well as SQUID magnetization and single-crystal X-ray crystallography studies.	sapropterin	167-171	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	159-165
25243488-5	2014	In addition to the unusual reactivity of the nitride 2, the resulting divalent cobalt complex 3 is a rare example of a trigonal pyramidal complex with four different donor ligands of a tetradentate chelate-an N-heterocyclic carbene, a phenolate, an imine, and an amine-binding to a high-spin Co(II) ion.	Cobalt	79-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	292-298
25243488-5	2014	In addition to the unusual reactivity of the nitride 2, the resulting divalent cobalt complex 3 is a rare example of a trigonal pyramidal complex with four different donor ligands of a tetradentate chelate-an N-heterocyclic carbene, a phenolate, an imine, and an amine-binding to a high-spin Co(II) ion.	carbene	224-231	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	292-298
25135438-2	2014	Bond Valence Sum (BVS) calculations and bond lengths indicate the presence of mixed valent Co (Co(II), Co(III)) centres in compounds and and only Co(III) centres in and as required for the charge balances and supported by the magnetic measurements.	Cobalt	91-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-101
25333664-6	2014	Pretreatment with a COX-2 or NF-kappaB-selective inhibitor (celecoxib or ammonium pyrrolidinedithiocarbamate) had an additive effect on the effusanin E-mediated inhibition of proliferation, while pretreatment with an activator of NF-kappaB/COX-2 (lipopolysaccharides) abrogated the effusanin E-mediated inhibition of proliferation.	Celecoxib	60-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-25
25201510-3	2014	The novel method also proved applicable for the synthesis of heteroaromatic unsymmetric diamides as well as a potent COX-2 enzyme inhibitor.	Diamide	88-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-122
25275501-0	2014	Molecular Co(II) and Co(III) heteroarylalkenolates as efficient precursors for chemical vapor deposition of Co3O4 nanowires.	co3o4	108-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-16
25275501-1	2014	Two new cobalt precursors, Co(II)(PyCHCOCF3)2(DMAP)2 (1) and Co(III)(PyCHCOCF3)3 (2), based on Co(II) and Co(III) centers were synthesized using a redox active ligand system.	Cobalt	8-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-52
25275501-1	2014	Two new cobalt precursors, Co(II)(PyCHCOCF3)2(DMAP)2 (1) and Co(III)(PyCHCOCF3)3 (2), based on Co(II) and Co(III) centers were synthesized using a redox active ligand system.	Cobalt	8-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-33
25333664-6	2014	Pretreatment with a COX-2 or NF-kappaB-selective inhibitor (celecoxib or ammonium pyrrolidinedithiocarbamate) had an additive effect on the effusanin E-mediated inhibition of proliferation, while pretreatment with an activator of NF-kappaB/COX-2 (lipopolysaccharides) abrogated the effusanin E-mediated inhibition of proliferation.	Celecoxib	60-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	240-245
25587329-2	2014	Specific COX-2 inhibitor celecoxib has been shown to enhance the sensitivity of cancer cells to anticancer drugs.	Celecoxib	25-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	9-14
25333664-6	2014	Pretreatment with a COX-2 or NF-kappaB-selective inhibitor (celecoxib or ammonium pyrrolidinedithiocarbamate) had an additive effect on the effusanin E-mediated inhibition of proliferation, while pretreatment with an activator of NF-kappaB/COX-2 (lipopolysaccharides) abrogated the effusanin E-mediated inhibition of proliferation.	pyrrolidine dithiocarbamic acid	73-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-25
25333664-6	2014	Pretreatment with a COX-2 or NF-kappaB-selective inhibitor (celecoxib or ammonium pyrrolidinedithiocarbamate) had an additive effect on the effusanin E-mediated inhibition of proliferation, while pretreatment with an activator of NF-kappaB/COX-2 (lipopolysaccharides) abrogated the effusanin E-mediated inhibition of proliferation.	pyrrolidine dithiocarbamic acid	73-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	240-245
25248683-0	2014	Enhanced water-soluble derivative of PC407 as a novel potential COX-2 inhibitor injectable formulation.	Water	9-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-69
25248683-0	2014	Enhanced water-soluble derivative of PC407 as a novel potential COX-2 inhibitor injectable formulation.	4-(5-naphthyl-3- (trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide	37-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-69
25248683-1	2014	PC407 is an effective COX-2 inhibitor in non-steroidal anti-inflammatory drug development but the poor solubility limits their usefulness.	4-(5-naphthyl-3- (trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide	0-5	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-27
25248683-4	2014	This derivative represents the profiles of prodrug and potential candidate of PC407 for the development of injectable COX-2 inhibitor due to extraordinary water solubility, low toxicity, and impressive analgesic activity.	4-(5-naphthyl-3- (trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide	78-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-123
25248683-4	2014	This derivative represents the profiles of prodrug and potential candidate of PC407 for the development of injectable COX-2 inhibitor due to extraordinary water solubility, low toxicity, and impressive analgesic activity.	Water	155-160	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-123
24840495-1	2014	An unexpected mononuclear Co(III) complex, [Co(L2)2 (CH3COO)] CH3OH (HL2=1-(2-{[(E)-3,5-dichloro-2-hydroxybenzylidene]amino}phenyl)ethanone oxime), has been synthesized via complexation of Co(II) acetate tetrahydrate with HL1 originally.	co(l2)2 (ch3coo)] ch3oh	44-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	189-195
24840495-1	2014	An unexpected mononuclear Co(III) complex, [Co(L2)2 (CH3COO)] CH3OH (HL2=1-(2-{[(E)-3,5-dichloro-2-hydroxybenzylidene]amino}phenyl)ethanone oxime), has been synthesized via complexation of Co(II) acetate tetrahydrate with HL1 originally.	1-(2-{[(e)-3,5-dichloro-2-hydroxybenzylidene]amino}phenyl)ethanone oxime	73-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	189-195
25317535-6	2014	Furthermore, treatment with mycosporine-Gly resulted in a significant decrease in COX-2 mRNA levels, which are typically increased in response to inflammation in the skin, in a concentration-dependent manner.	mycosporine-gly	28-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
25408841-2	2014	Deletion of the SO2CH3 group of rofecoxib switches the compound from a COX-2- to a COX-1-selective inhibitor, providing a 3,4-diarylfuran-2(5H)-one scaffold for structure-activity relationship studies of COX-1 inhibition.	rofecoxib	32-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-76
24961511-12	2014	Gene expression analysis showed that several genes involved in tumor development and metastasis (EGR1, COX2, MALAT1, AKAP12, ADM) were similarly induced in CSC and cisplatin-resistant H460 cells, in agreement with a close similarity between these two cell populations.	Cisplatin	164-173	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-107
24894428-9	2014	Cancer cells released soluble factors that inhibited granzyme B, perforin and IFN-gamma production that was partially associated with the PGE2 /COX2 pathway.	Dinoprostone	138-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	144-148
24907682-3	2014	Compounds 8a, 10c and 13c were the most potent and selective ligands against COX-2 with inhibition percentages of 79.6%, 78.7% and 78.9% at a concentration of 2 muM respectively, while compound 13c significantly inhibited both COX subtypes.	13c	22-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-82
24671668-0	2014	Sulforaphane inhibits IL-1beta-induced proliferation of rheumatoid arthritis synovial fibroblasts and the production of MMPs, COX-2, and PGE2.	sulforaphane	0-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-131
24671668-4	2014	Sulforaphane inhibits unstimulated and IL-1beta-induced proliferation of RASFs; the expression of MMP-1, MMP-3, and COX-2 mRNA and protein; and the PGE2 production induced by IL-1beta.	sulforaphane	0-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-121
24671668-6	2014	These results indicate that sulforaphane inhibits the proliferation of synovial fibroblasts, the expression of MMPs and COX-2, and the production of PGE2, which are involved in synovitis and destruction of RA, and suggest that sulforaphane might be a new therapeutic agent for RA.	sulforaphane	28-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-125
25587329-6	2014	The COX-2 inhibitor celecoxib up-regulated the expression of ABCG2 mRNA in MCF-7 and MCF7-MX cells, which was accompanied by increased ABCG2 protein expression.	Celecoxib	20-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
25587329-7	2014	While celecoxib was able to block the 12-O-tetradecanoylphorbol-13-acetate (TPA)-mediated increase in COX-2 expression in MDA-MB-231 cells, it increased the expression of ABCG2 up to 4.27 times to the control level at mRNA level and with less intensity at protein level.	Celecoxib	6-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-107
25587329-7	2014	While celecoxib was able to block the 12-O-tetradecanoylphorbol-13-acetate (TPA)-mediated increase in COX-2 expression in MDA-MB-231 cells, it increased the expression of ABCG2 up to 4.27 times to the control level at mRNA level and with less intensity at protein level.	Tetradecanoylphorbol Acetate	38-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-107
25587329-7	2014	While celecoxib was able to block the 12-O-tetradecanoylphorbol-13-acetate (TPA)-mediated increase in COX-2 expression in MDA-MB-231 cells, it increased the expression of ABCG2 up to 4.27 times to the control level at mRNA level and with less intensity at protein level.	Tetradecanoylphorbol Acetate	76-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-107
25271420-5	2014	Our data showed that resveratrol, used in a concentration 20 times lower than 5-aminosalicylic acid, was able to significantly reduce NO and PGE2 production, iNOS and COX-2 expression and reactive oxidant species formation induced by the cytokine challenge.	Resveratrol	21-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	167-172
25094029-0	2014	Downregulation of COX-2 and CYP 4A signaling by isoliquiritigenin inhibits human breast cancer metastasis through preventing anoikis resistance, migration and invasion.	isoliquiritigenin	48-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-23
25094029-3	2014	Here, we demonstrate that isoliquiritigenin (ISL), a flavonoid from Glycyrrhiza glabra, inhibits human breast cancer metastasis by preventing anoikis resistance, migration and invasion through downregulating cyclooxygenase (COX)-2 and cytochrome P450 (CYP) 4A signaling.	isoliquiritigenin	26-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	208-230
25094029-3	2014	Here, we demonstrate that isoliquiritigenin (ISL), a flavonoid from Glycyrrhiza glabra, inhibits human breast cancer metastasis by preventing anoikis resistance, migration and invasion through downregulating cyclooxygenase (COX)-2 and cytochrome P450 (CYP) 4A signaling.	isoliquiritigenin	45-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	208-230
25124276-14	2014	The active methanolic fraction was also found to inhibit the expression of NF-kappaB and COX-2 induced by carrageenan.	Carrageenan	106-117	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-94
25484680-1	2014	In the title complex, [Co(C15H6ClO4)2(H2O)4] 2H2O, the Co(II) ion is bound by two carboxylate O atoms of two 5-chloro-9,10-anthra-quinone-1-carboxyl-ate anions and four water O atoms in a trans conformation, forming an irregular octa-hedral coordination geometry.	[co(c15h6clo4)2(h2o)4] 2h2o	22-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-61
25484680-1	2014	In the title complex, [Co(C15H6ClO4)2(H2O)4] 2H2O, the Co(II) ion is bound by two carboxylate O atoms of two 5-chloro-9,10-anthra-quinone-1-carboxyl-ate anions and four water O atoms in a trans conformation, forming an irregular octa-hedral coordination geometry.	carboxylate	82-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-61
25484680-1	2014	In the title complex, [Co(C15H6ClO4)2(H2O)4] 2H2O, the Co(II) ion is bound by two carboxylate O atoms of two 5-chloro-9,10-anthra-quinone-1-carboxyl-ate anions and four water O atoms in a trans conformation, forming an irregular octa-hedral coordination geometry.	5-chloro-9,10-anthra-quinone-1-carboxyl-ate anions	109-159	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-61
25484680-1	2014	In the title complex, [Co(C15H6ClO4)2(H2O)4] 2H2O, the Co(II) ion is bound by two carboxylate O atoms of two 5-chloro-9,10-anthra-quinone-1-carboxyl-ate anions and four water O atoms in a trans conformation, forming an irregular octa-hedral coordination geometry.	Water	169-174	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-61
25144313-6	2014	A polarity-sensitive naphthalene derivative (BTDAN) as fluorophore was introduced into the molecule to enhance two-photon properties of BTDAN-COX-2.	naphthalene	21-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	142-147
25144313-6	2014	A polarity-sensitive naphthalene derivative (BTDAN) as fluorophore was introduced into the molecule to enhance two-photon properties of BTDAN-COX-2.	btdan	45-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	142-147
25148569-0	2014	Cooperative metal-ligand assisted E/Z isomerization and cyano activation at Cu(II) and Co(II) complexes of arylhydrazones of active methylene nitriles.	Metals	12-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-93
25148569-0	2014	Cooperative metal-ligand assisted E/Z isomerization and cyano activation at Cu(II) and Co(II) complexes of arylhydrazones of active methylene nitriles.	arylhydrazones	107-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-93
25148569-0	2014	Cooperative metal-ligand assisted E/Z isomerization and cyano activation at Cu(II) and Co(II) complexes of arylhydrazones of active methylene nitriles.	methylene nitriles	132-150	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-93
26839798-1	2015	In order to develop new selective COX-2 inhibitors, a new series of 2-phenyl-4H-chromen-4-one derivatives possessing a methylsulfonyl pharmacophore group at the para position of the C-4 phenyl ring were designed, synthesized, and evaluated for cyclooxygenase-2 inhibitory activity.	flavone	68-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-39
26839798-2	2015	In vitro COX-1/COX-2 isozyme inhibition structure-activity studies identified 3-(benzyloxy)-2-[4-(methylsulfonyl)phenyl]-4H-chromen-4-one (5d) as a potent COX-2 inhibitor (IC50 = 0.07 muM) with a high COX-2 selectivity index (SI = 287.1) comparable to the reference drug celecoxib (COX-2 IC50 = 0.06 muM; COX-2 SI = 405).	3-(benzyloxy)-2-[4-(methylsulfonyl)phenyl]-4h-chromen-4-one	78-137	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-20
26839798-2	2015	In vitro COX-1/COX-2 isozyme inhibition structure-activity studies identified 3-(benzyloxy)-2-[4-(methylsulfonyl)phenyl]-4H-chromen-4-one (5d) as a potent COX-2 inhibitor (IC50 = 0.07 muM) with a high COX-2 selectivity index (SI = 287.1) comparable to the reference drug celecoxib (COX-2 IC50 = 0.06 muM; COX-2 SI = 405).	3-(benzyloxy)-2-[4-(methylsulfonyl)phenyl]-4h-chromen-4-one	78-137	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	155-160
26839798-2	2015	In vitro COX-1/COX-2 isozyme inhibition structure-activity studies identified 3-(benzyloxy)-2-[4-(methylsulfonyl)phenyl]-4H-chromen-4-one (5d) as a potent COX-2 inhibitor (IC50 = 0.07 muM) with a high COX-2 selectivity index (SI = 287.1) comparable to the reference drug celecoxib (COX-2 IC50 = 0.06 muM; COX-2 SI = 405).	3-(benzyloxy)-2-[4-(methylsulfonyl)phenyl]-4h-chromen-4-one	78-137	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	155-160
26839798-2	2015	In vitro COX-1/COX-2 isozyme inhibition structure-activity studies identified 3-(benzyloxy)-2-[4-(methylsulfonyl)phenyl]-4H-chromen-4-one (5d) as a potent COX-2 inhibitor (IC50 = 0.07 muM) with a high COX-2 selectivity index (SI = 287.1) comparable to the reference drug celecoxib (COX-2 IC50 = 0.06 muM; COX-2 SI = 405).	3-(benzyloxy)-2-[4-(methylsulfonyl)phenyl]-4h-chromen-4-one	78-137	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	155-160
26839798-2	2015	In vitro COX-1/COX-2 isozyme inhibition structure-activity studies identified 3-(benzyloxy)-2-[4-(methylsulfonyl)phenyl]-4H-chromen-4-one (5d) as a potent COX-2 inhibitor (IC50 = 0.07 muM) with a high COX-2 selectivity index (SI = 287.1) comparable to the reference drug celecoxib (COX-2 IC50 = 0.06 muM; COX-2 SI = 405).	3-(benzyloxy)-2-[4-(methylsulfonyl)phenyl]-4h-chromen-4-one	78-137	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	155-160
26839798-2	2015	In vitro COX-1/COX-2 isozyme inhibition structure-activity studies identified 3-(benzyloxy)-2-[4-(methylsulfonyl)phenyl]-4H-chromen-4-one (5d) as a potent COX-2 inhibitor (IC50 = 0.07 muM) with a high COX-2 selectivity index (SI = 287.1) comparable to the reference drug celecoxib (COX-2 IC50 = 0.06 muM; COX-2 SI = 405).	Celecoxib	271-280	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-20
26839798-4	2015	The structure-activity data acquired indicated that the nature and size of the substituent on the C-3 chromene scaffold are important for COX-2 inhibitory activity.	c-3 chromene	98-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	138-143
26839798-5	2015	Our results also indicated that the chromene moiety constitutes a suitable template to design new COX-2 inhibitors.	Benzopyrans	36-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-103
25117517-4	2014	Here we report on an improved redox buffer platform based on equimolar amounts of the much less hydrophilic Co(III) and Co(II) complexes of 4,4"-dinonyl-2,2"-bipyridyl, which makes it possible to extend the redox buffer approach to ionophore-based ISEs.	4,4"-dinonyl-2,2"-bipyridyl	140-167	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-126
25122190-1	2014	Saddle-shaped Co(II)[OET(p-R)PP] (R = CF3, H, CH3) can be readily oxidized with Cl2, Br2, and I2 to the corresponding one-electron-oxidation product Co[OET(p-R)PP]X (X = Cl, Br, I) with the clear character of a ring cation radical.	oet(p-r)pp	21-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-20
25122190-1	2014	Saddle-shaped Co(II)[OET(p-R)PP] (R = CF3, H, CH3) can be readily oxidized with Cl2, Br2, and I2 to the corresponding one-electron-oxidation product Co[OET(p-R)PP]X (X = Cl, Br, I) with the clear character of a ring cation radical.	Chlorine	80-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-20
25122190-1	2014	Saddle-shaped Co(II)[OET(p-R)PP] (R = CF3, H, CH3) can be readily oxidized with Cl2, Br2, and I2 to the corresponding one-electron-oxidation product Co[OET(p-R)PP]X (X = Cl, Br, I) with the clear character of a ring cation radical.	Bromine	85-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-20
25122190-1	2014	Saddle-shaped Co(II)[OET(p-R)PP] (R = CF3, H, CH3) can be readily oxidized with Cl2, Br2, and I2 to the corresponding one-electron-oxidation product Co[OET(p-R)PP]X (X = Cl, Br, I) with the clear character of a ring cation radical.	co[oet(p-r)pp	149-162	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-20
25122190-1	2014	Saddle-shaped Co(II)[OET(p-R)PP] (R = CF3, H, CH3) can be readily oxidized with Cl2, Br2, and I2 to the corresponding one-electron-oxidation product Co[OET(p-R)PP]X (X = Cl, Br, I) with the clear character of a ring cation radical.	Bromine	85-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-20
25136992-2	2014	They are of formula [M(L)(N3)]n 3nH2O [M = Mn(II), Co(II), and Ni(II)].	m(l)(n3)]n 3nh2o	21-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-56
25202054-0	2014	LLW-3-6 and celecoxib impacts growth in prostate cancer cells and subcellular localization of COX-2.	Celecoxib	12-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-99
25202054-5	2014	Localization of COX-2 in LLW-3-6- and CBX-treated PC3 cells is consistent with protein aggregation known for cells responding to stress stimuli.	Carboxin	38-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-21
25074847-2	2014	In this study, we have investigated the effect of artesunate on PGE2 production/COX-2 protein expression in LPS+IFNgamma-activated BV2 microglia.	Artesunate	50-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-85
25045102-1	2014	Two new trihydrazine bridged Co(II) chain compounds have been synthesized and magnetically characterized.	trihydrazine	8-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-35
25229174-1	2014	Etoricoxib is a newer cyclooxygenase (COX)-2 inhibitor anti-inflammatory drug with a favorable safety profile.	Etoricoxib	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-44
24796340-10	2014	Our results suggest that a genetic decrease in COX-2 activity may be beneficial with respect to CVD risk, especially, in higher risk patients on aspirin.	Aspirin	145-152	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
24938358-5	2014	The upregulation of COX-2 caused by HBx through generation of mitochondrial reactive oxygen species promoted cell growth.	Reactive Oxygen Species	76-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-25
24501112-11	2014	Wogonin, baicalin, and berberine inhibited expression of COX-2 mRNA without affecting PGE2 metabolic activity.	Berberine	23-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-62
25255073-1	2014	Meloxicam is a commonly used COX2-preferential NSAID in both human and veterinary patients.	Meloxicam	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-33
25054056-3	2014	Cyclooxygenase (COX)-2 regulates the production of prostaglandins and is overexpressed in a variety of solid tumors.	Prostaglandins	51-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-22
25047043-2	2014	The oxidative conversion of arachidonic acid to prostaglandin H2 is carried out by two isozymes of cyclooxygenase, COX-1 and COX-2.	Arachidonic Acid	28-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-130
25047043-2	2014	The oxidative conversion of arachidonic acid to prostaglandin H2 is carried out by two isozymes of cyclooxygenase, COX-1 and COX-2.	Prostaglandin H2	48-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-130
25047043-9	2014	Introduction of miR-146a can specifically ablate COX-2 protein and the biological activity of COX-2 as measured by prostaglandin production.	Prostaglandins	115-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-99
24967690-0	2014	Eupafolin inhibits PGE2 production and COX2 expression in LPS-stimulated human dermal fibroblasts by blocking JNK/AP-1 and Nox2/p47(phox) pathway.	eupafolin	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-43
24867094-8	2014	Furthermore, crebanine suppressed the TNF-alpha-mediated expression of proteins that involved cancer cell invasion (matrix metalloproteinase 9 urokinase-type plasminogen activator, urokinase-type plasminogen activator receptor and intercellular adhesion molecule 1) and angiogenesis (COX-2 and VEGF), all of which are known to be regulated by NF-kappaB.	crebanine	13-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	284-289
25559449-3	2014	Here we developed an improved method for evaluating the enzyme activity and screening COX-2 inhibitors using ultrahigh-performance liquid chromatography/tandem mass spectrometry (UPLC/MS/MS) combined with PGE2 derivatization.	Dinoprostone	205-209	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-91
25559449-5	2014	The established method was performed to screen the COX-2 inhibitors from effective constituents of herbs and detect the concentration of PGE2 in biological tissue samples (liver and kidney).	Dinoprostone	137-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-56
25559449-6	2014	The IC50 values of celecoxib, rofecoxib, sinomenine, bulleyaconitine A, tetrandrine, fangchinoline, berberine hydrochloride and sophocarpidine towards COX-2 were determined.	Celecoxib	19-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-156
25559449-6	2014	The IC50 values of celecoxib, rofecoxib, sinomenine, bulleyaconitine A, tetrandrine, fangchinoline, berberine hydrochloride and sophocarpidine towards COX-2 were determined.	rofecoxib	30-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-156
25559449-6	2014	The IC50 values of celecoxib, rofecoxib, sinomenine, bulleyaconitine A, tetrandrine, fangchinoline, berberine hydrochloride and sophocarpidine towards COX-2 were determined.	sinomenine	41-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-156
25559449-6	2014	The IC50 values of celecoxib, rofecoxib, sinomenine, bulleyaconitine A, tetrandrine, fangchinoline, berberine hydrochloride and sophocarpidine towards COX-2 were determined.	bulleyaconitine A	53-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-156
25559449-6	2014	The IC50 values of celecoxib, rofecoxib, sinomenine, bulleyaconitine A, tetrandrine, fangchinoline, berberine hydrochloride and sophocarpidine towards COX-2 were determined.	tetrandrine	72-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-156
25559449-6	2014	The IC50 values of celecoxib, rofecoxib, sinomenine, bulleyaconitine A, tetrandrine, fangchinoline, berberine hydrochloride and sophocarpidine towards COX-2 were determined.	fangchinoline	85-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-156
25559449-6	2014	The IC50 values of celecoxib, rofecoxib, sinomenine, bulleyaconitine A, tetrandrine, fangchinoline, berberine hydrochloride and sophocarpidine towards COX-2 were determined.	berberine chloride	100-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-156
25559449-6	2014	The IC50 values of celecoxib, rofecoxib, sinomenine, bulleyaconitine A, tetrandrine, fangchinoline, berberine hydrochloride and sophocarpidine towards COX-2 were determined.	oxysophocarpine	128-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-156
25559449-9	2014	Besides the positive control, sinomenine (IC50 =113 muM) and bulleyaconitine A (IC50=53 muM) were found to be potent COX-2 inhibitors.	sinomenine	30-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-122
25559449-9	2014	Besides the positive control, sinomenine (IC50 =113 muM) and bulleyaconitine A (IC50=53 muM) were found to be potent COX-2 inhibitors.	bulleyaconitine A	61-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-122
25559449-10	2014	CONCLUSIONS: All the results indicate that the present derivatization quantification method of PGE2 could be used as the detection method of COX-2 enzyme activity and as the screening method for COX-2 inhibitors.	Dinoprostone	95-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	141-146
25559449-10	2014	CONCLUSIONS: All the results indicate that the present derivatization quantification method of PGE2 could be used as the detection method of COX-2 enzyme activity and as the screening method for COX-2 inhibitors.	Dinoprostone	95-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	195-200
25168879-0	2014	Staurosporine synergistically potentiates the deoxycholate-mediated induction of COX-2 expression.	Staurosporine	0-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-86
25168879-0	2014	Staurosporine synergistically potentiates the deoxycholate-mediated induction of COX-2 expression.	Deoxycholic Acid	46-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-86
25168879-4	2014	The expression of cyclooxygenase (COX)-2, an inducible isozyme of cyclooxygenase, is induced by bile acids and correlates with the incidence and progression of cancers.	Bile Acids and Salts	96-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-40
25168879-5	2014	In this study, we investigated the signal transduction pathways involved in the bile-acid-mediated induction of COX-2 expression.	Bile Acids and Salts	80-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-117
25168879-6	2014	We found that staurosporine (sts), a potent protein kinase C (PKC) inhibitor, synergistically potentiated the deoxycholate-mediated induction of COX-2 expression.	Staurosporine	14-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-150
25168879-6	2014	We found that staurosporine (sts), a potent protein kinase C (PKC) inhibitor, synergistically potentiated the deoxycholate-mediated induction of COX-2 expression.	Staurosporine	29-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-150
25168879-6	2014	We found that staurosporine (sts), a potent protein kinase C (PKC) inhibitor, synergistically potentiated the deoxycholate-mediated induction of COX-2 expression.	Deoxycholic Acid	110-122	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-150
25168879-8	2014	The sts- and deoxycholate-mediated synergistic induction of COX-2 expression was suppressed by a membrane-permeable Ca(2+) chelator, a phosphoinositide 3-kinase inhibitor, a nuclear factor-kappaB pathway inhibitor, and inhibitors of canonical and stress-inducible mitogen-activated protein kinase pathways.	Deoxycholic Acid	13-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-65
25168879-12	2014	We conclude that staurosporine synergistically enhances deoxycholate-induced COX-2 expression in RCM-1 colon cancer cells.	Staurosporine	17-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-82
25168879-12	2014	We conclude that staurosporine synergistically enhances deoxycholate-induced COX-2 expression in RCM-1 colon cancer cells.	Deoxycholic Acid	56-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-82
24983538-0	2014	Novel 1-[4-(Aminosulfonyl)phenyl]-1H-1,2,4-triazole derivatives with remarkable selective COX-2 inhibition: design, synthesis, molecular docking, anti-inflammatory and ulcerogenicity studies.	1-(4-(aminosulfonyl)phenyl)-1H-1,2,4-triazole	6-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-95
24983538-5	2014	The additional H-bonds with the oxygen of the amide and/or H of NH of the amide with the amino acid residues may be responsible for the higher binding affinity of this group of compounds towards COX-2.	Oxygen	32-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	195-200
24983538-5	2014	The additional H-bonds with the oxygen of the amide and/or H of NH of the amide with the amino acid residues may be responsible for the higher binding affinity of this group of compounds towards COX-2.	Amides	46-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	195-200
24983538-5	2014	The additional H-bonds with the oxygen of the amide and/or H of NH of the amide with the amino acid residues may be responsible for the higher binding affinity of this group of compounds towards COX-2.	Amides	74-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	195-200
26290896-4	2014	We also found that a PPARdelta downstream pathway, namely the COX-2-derived PGE2 signaling, mediated crosstalk between tumor epithelial cells and macrophages to promote chronic inflammation and colitis-associated tumor genesis.	Dinoprostone	76-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
26290896-5	2014	In this brief review, we summarize recent studies on the role of PPARdelta in inflammatory bowel disease (IBD) and colorectal cancer (CRC) and highlight recent advances in our understanding of how PPARdelta and COX-2-drevided PGE2 signaling coordinately promote chronic colonic inflammation and colitis-associate tumorigenesis.	Dinoprostone	226-230	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	211-216
25419347-8	2014	When these cells were treated with H2O2, there was higher expression of NOX-4, TNF-alpha and COX-2 mRNA.	Hydrogen Peroxide	35-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-98
25129543-11	2014	EGR-1 was found to induce expression of COX-2 in the SGA group (P &lt; 0.01) and both, EGR-1 and COX-2 stimulated glucose uptake in MSCs (P &lt; 0.01).	Glucose	114-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
25299780-10	2014	Finally, TRAIL-induced expression of COX-2 was diminished through siRNA targeting c-Rel or NFATc2 and pharmacologic inhibition of COX-2 with celecoxib or siRNA targeting COX-2, enhanced TRAIL apoptosis.	Celecoxib	141-150	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-42
25299780-10	2014	Finally, TRAIL-induced expression of COX-2 was diminished through siRNA targeting c-Rel or NFATc2 and pharmacologic inhibition of COX-2 with celecoxib or siRNA targeting COX-2, enhanced TRAIL apoptosis.	Celecoxib	141-150	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	130-135
25299780-10	2014	Finally, TRAIL-induced expression of COX-2 was diminished through siRNA targeting c-Rel or NFATc2 and pharmacologic inhibition of COX-2 with celecoxib or siRNA targeting COX-2, enhanced TRAIL apoptosis.	Celecoxib	141-150	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	130-135
25317410-10	2014	CONCLUSION: We verified that silibinin had anticancer effect on xenograft model of MDA-MB-468 cells in the way of preventing the phosphorylation of EGFR and eventually suppressed the production of COX-2, VEGF, and MMP-9 expression.	Silybin	29-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	197-202
24902855-12	2014	CONCLUSIONS AND IMPLICATIONS: These findings demonstrate that MAPKs-mediated activation of AP-1/NF-kappaB pathways is, at least in part, required for COX-2/PGE2 /EP2 -triggered cell proliferation in human cardiomyocytes.	Dinoprostone	156-160	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	150-155
25234831-0	2014	Orange peel extract, containing high levels of polymethoxyflavonoid, suppressed UVB-induced COX-2 expression and PGE2 production in HaCaT cells through PPAR-gamma activation.	polymethoxyflavonoid	47-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-97
25234831-7	2014	The suppression of UVB-induced COX-2 expression by this extract was inhibited by GW 9662 and T0070907, which are both PPAR-gamma antagonists.	glycyltryptophan	81-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-36
25066075-2	2014	Celecoxib (CXB), a selective COX-2 inhibitor, is able to control inflammation and pain, to improve the efficacy of radiotherapy, and to inhibit at high doses the growth of cancer cells.	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34
25066075-2	2014	Celecoxib (CXB), a selective COX-2 inhibitor, is able to control inflammation and pain, to improve the efficacy of radiotherapy, and to inhibit at high doses the growth of cancer cells.	Celecoxib	11-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34
24990321-0	2014	Sphingosine-1-phosphate induces thrombin receptor PAR-4 expression to enhance cell migration and COX-2 formation in human monocytes.	sphingosine 1-phosphate	0-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
24990321-7	2014	PAR-4-mediated induction of COX-2 was prevented by the PI3K inhibitor LY (10 muM).	Lysine	70-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
25175318-0	2014	Effect of NSAIDS and COX-2 inhibitors on the incidence and severity of asbestos-induced malignant mesothelioma: evidence from an animal model and a human cohort.	Asbestos	71-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-26
25175318-2	2014	Because asbestos can cause chronic inflammation at the pleural and peritoneal surfaces we hypothesised that NSAID and COX-2 inhibitors would inhibit the development of asbestos-induced mesothelioma.	Asbestos	8-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-123
25110109-0	2014	Helicobacter pylori promotes VEGF expression via the p38 MAPK-mediated COX-2-PGE2 pathway in MKN45 cells.	Dinoprostone	77-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-76
25110109-6	2014	In combination, these results suggest that VEGF expression is regulated by the p38 MAPK COX-2-PGE2-EP2/EP4 pathway in gastric cancer cells induced by H. pylori.	Dinoprostone	94-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-93
25124319-7	2014	COX-1 and COX-2 was localized to epithelium and connective tissue in human gingival tissue sections from cyclosporine induced gingival overgrowth.	Cyclosporine	105-117	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
25271421-5	2014	Subsequently, we tested the ability of meloxicam, a selective COX-2 inhibitor, to attenuate behavioral deficits via inflammatory mechanisms.	Meloxicam	39-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
25751962-1	2014	The new generation cyclooxygenase (COX-2) inhibitor could reduce the gastrointestinal side effect of NSAID drugs, but eventually increase the cardiovascular risk, because its selective inhibition of COX-2 induces the imbalance between PGI2 and TXA2 and the reduction of vasodilatory NO.	Epoprostenol	235-239	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40
25751962-1	2014	The new generation cyclooxygenase (COX-2) inhibitor could reduce the gastrointestinal side effect of NSAID drugs, but eventually increase the cardiovascular risk, because its selective inhibition of COX-2 induces the imbalance between PGI2 and TXA2 and the reduction of vasodilatory NO.	Epoprostenol	235-239	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	199-204
25751962-5	2014	If antioxidant structures with active ingredients of traditional Chinese medicines were introduced to improve the antioxidant activity of NSAIDs, they could scavenge the active oxygen species to protect the normal function of vascular endothelia and enhance the bioavailability of NO, which is conducive to enhance the cardiovascular safety of cyclooxygenase (COX-2) inhibitor.	Oxygen	177-183	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	360-365
25250794-0	2014	The inhibitory effect of pseudolaric acid B on gastric cancer and multidrug resistance via Cox-2/PKC-alpha/P-gp pathway.	pseudolaric acid B	25-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-96
25250794-8	2014	CONCLUSION: Pseudolaric acid B has a significant inhibitory effect and an additive inhibitory effect in combination with adriamycin on the growth of gastric cancer in vivo, which reverses the multidrug resistance of gastric neoplasm to chemotherapy drugs by downregulating the Cox-2/PKC-alpha/P-gp/mdr1 signaling pathway.	pseudolaric acid B	12-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	277-282
25033219-2	2014	However, the orange single crystal of [2](NO3)2 transforms to the single crystal of monomeric [Co(II)(hep-H)2(NO3)]NO3 [4]NO3 (orange) upon exposure to heat (110  C) where one of the NO3(-) counter anions in [2](NO3)2 moves to the coordination sphere.	[2](no3)2	38-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-101
25033219-2	2014	However, the orange single crystal of [2](NO3)2 transforms to the single crystal of monomeric [Co(II)(hep-H)2(NO3)]NO3 [4]NO3 (orange) upon exposure to heat (110  C) where one of the NO3(-) counter anions in [2](NO3)2 moves to the coordination sphere.	punky blue	42-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-101
25033219-2	2014	However, the orange single crystal of [2](NO3)2 transforms to the single crystal of monomeric [Co(II)(hep-H)2(NO3)]NO3 [4]NO3 (orange) upon exposure to heat (110  C) where one of the NO3(-) counter anions in [2](NO3)2 moves to the coordination sphere.	[2](no3)2	208-217	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-101
25033219-4	2014	Moreover, the immersion of the pink single crystal of 3 in 1 N HCl results in a green single crystal of ionic monomeric [Co(II)(H2O)6] SO4[5]SO4, which indeed demonstrates the unprecedented unique two-step SCSC transformations.	Hydrochloric Acid	63-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-127
25033219-4	2014	Moreover, the immersion of the pink single crystal of 3 in 1 N HCl results in a green single crystal of ionic monomeric [Co(II)(H2O)6] SO4[5]SO4, which indeed demonstrates the unprecedented unique two-step SCSC transformations.	sulfuric acid	135-138	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-127
25122505-7	2014	Catechol (10-50 microM) suppressed COX-1 activity by 29-44% and COX-2 activity by 29-50%.	catechol	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-69
25136992-5	2014	The magnetic coupling through (mu-1,1-N3)(mu-1,3-COO)2 is antiferromagnetic in the Mn(II) compound but ferromagnetic in the Co(II) and Ni(II) analogues.	(mu-1,1-n3)(mu-1,3-coo)2	30-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	124-130
25136992-8	2014	With strong magnetic anisotropy, the Co(II) compound behaves as a single-chain magnet showing hysteresis and Glauber-type slow dynamics probably in the infinite-chain region, with Delta(tau)/k = 86 K, Delta(xi)/k = 26 K, and Delta(A)/k = 34 K. With weaker anisotropy, the Ni(II) species shows slow relaxation of magnetization at much lower temperature.	Nickel(2+)	272-278	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-43
24842191-8	2014	Miconazole also inhibited RANKL-induced expression of the pro-inflammatory cytokines, COX-2 and iNOS.	Miconazole	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-91
25010336-4	2014	Interestingly, it was found that the CTAB bilayer confined at the interface of carbon dots can amplify H2O2 induced ultraweak CL emissions, such as the Co(II)-triggered Fenton-like reaction, the peroxynitrous acid (ONOOH) system, and the peroxymonocarbonate (HCO4(-)) system.	Cetrimonium	37-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-157
24910117-5	2014	Western blot assay data demonstrated that curcumin inhibited phosphorylation of PI3K and Akt signaling pathways and subsequently attenuated MMP1/7 and COX-2 protein expressions in FTC133.	Curcumin	42-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-156
24989818-2	2014	Due to the strong fluorescence of the acridine yellow fluorophore, it is not completely quenched when the ligand is coordinated to Co(II) .	Acridines	38-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-137
25010336-4	2014	Interestingly, it was found that the CTAB bilayer confined at the interface of carbon dots can amplify H2O2 induced ultraweak CL emissions, such as the Co(II)-triggered Fenton-like reaction, the peroxynitrous acid (ONOOH) system, and the peroxymonocarbonate (HCO4(-)) system.	Carbon	79-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-157
25010336-4	2014	Interestingly, it was found that the CTAB bilayer confined at the interface of carbon dots can amplify H2O2 induced ultraweak CL emissions, such as the Co(II)-triggered Fenton-like reaction, the peroxynitrous acid (ONOOH) system, and the peroxymonocarbonate (HCO4(-)) system.	Hydrogen Peroxide	103-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-157
25010336-4	2014	Interestingly, it was found that the CTAB bilayer confined at the interface of carbon dots can amplify H2O2 induced ultraweak CL emissions, such as the Co(II)-triggered Fenton-like reaction, the peroxynitrous acid (ONOOH) system, and the peroxymonocarbonate (HCO4(-)) system.	peroxycarbonic acid	238-257	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-157
25010336-4	2014	Interestingly, it was found that the CTAB bilayer confined at the interface of carbon dots can amplify H2O2 induced ultraweak CL emissions, such as the Co(II)-triggered Fenton-like reaction, the peroxynitrous acid (ONOOH) system, and the peroxymonocarbonate (HCO4(-)) system.	hco4	259-263	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-157
24934992-0	2014	Novel pyrazoline derivatives as bi-inhibitor of COX-2 and B-Raf in treating cervical carcinoma.	pyrazoline	6-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-53
25057907-1	2014	A new homonuclear single-chain magnet self-assembles as a one-dimensional coordination network of defective dicubane {Co(II)4} complexes linked by single Co(II) ions with the assistance of azido and picolinate ligands.	dicubane	108-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-124
25057907-1	2014	A new homonuclear single-chain magnet self-assembles as a one-dimensional coordination network of defective dicubane {Co(II)4} complexes linked by single Co(II) ions with the assistance of azido and picolinate ligands.	picolinic acid	199-209	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-124
24934992-1	2014	Twenty four pyrazoline derivatives modified from Celecoxib were designed and synthesized as bi-inhibitor of COX-2 and B-Raf.	pyrazoline	12-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-113
24934992-1	2014	Twenty four pyrazoline derivatives modified from Celecoxib were designed and synthesized as bi-inhibitor of COX-2 and B-Raf.	Celecoxib	49-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-113
24859418-3	2014	The treatment of neuroblastoma cells in vitro with celecoxib, a COX2 inhibitor, induces apoptosis.	Celecoxib	51-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-68
25085874-3	2014	Therefore, we examined the association between recent (1 year) prediagnostic use of aspirin (COX1/COX2 inhibitor), lymph node involvement at breast cancer diagnosis, and breast cancer-specific mortality.	Aspirin	84-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-102
24220749-1	2014	The present work was conducted to examine whether celecoxib, a selective COX-2 inhibitor, 200 mg administered 1 h preoperatively to patients undergoing arthroscopic hip surgery reduces postoperative pain.	Celecoxib	50-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-78
24953043-1	2014	Aspirin (ASA) is a commonly used nonsteroidal anti-inflammatory drug (NSAID), which exerts its therapeutic effects through inhibition of cyclooxygenase (COX) isoform 2 (COX-2), while the inhibition of COX-1 by ASA leads to apparent side effects.	Aspirin	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	169-174
24953043-1	2014	Aspirin (ASA) is a commonly used nonsteroidal anti-inflammatory drug (NSAID), which exerts its therapeutic effects through inhibition of cyclooxygenase (COX) isoform 2 (COX-2), while the inhibition of COX-1 by ASA leads to apparent side effects.	Aspirin	9-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	169-174
24953043-1	2014	Aspirin (ASA) is a commonly used nonsteroidal anti-inflammatory drug (NSAID), which exerts its therapeutic effects through inhibition of cyclooxygenase (COX) isoform 2 (COX-2), while the inhibition of COX-1 by ASA leads to apparent side effects.	Aspirin	210-213	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	169-174
24969217-2	2014	We have previously demonstrated that COX2-derived prostaglandin E2 (PGE2) promotes human ovarian cancer cell invasion.	Dinoprostone	50-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-41
24969217-2	2014	We have previously demonstrated that COX2-derived prostaglandin E2 (PGE2) promotes human ovarian cancer cell invasion.	Dinoprostone	68-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-41
24969217-8	2014	Moreover, we also showed that EGF-induced cell invasion is attenuated by treatment with a selective COX2 inhibitor, NS-398, as well as PGE2 siRNA.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	116-122	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-104
24969217-9	2014	This study demonstrates an important role for COX2 and its derivative, PGE2, in the mediation of the effects of EGF on human ovarian cancer cell invasion.	Dinoprostone	71-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-50
26674754-5	2014	This article reviews those components in the CP-PC connection, including the role of macrophages, the maintenance of genome stability, cytokines, and other nodal factors such as nuclear factor kappa B, COX-2 and reactive oxygen species.	cp-pc	45-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	202-207
24481501-0	2014	Insights into the mechanisms underlying the antiproliferative potential of a Co(II) coordination compound bearing 1,10-phenanthroline-5,6-dione: DNA and protein interaction studies.	1,10-phenanthroline-5,6-dione	114-143	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-83
24461582-1	2014	BACKGROUND: Prostaglandins that constrict and relax airways are synthesized in reactions catalyzed by either COX-1 or COX-2.	Prostaglandins	12-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-123
24461582-3	2014	OBJECTIVE: To determine the effects of the selective COX-2 inhibitor, etoricoxib, on allergen-induced bronchoconstriction in asthmatic subjects.	Etoricoxib	70-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-58
24998701-5	2014	Since the distance between the cobalt ions is quite large (11.59 A), this is attributed in a first instance to the intrinsic properties of each Co(II) center (single-ion magnet behavior).	Cobalt	31-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	144-150
24631063-8	2014	Piroxicam inhibited Masitinib-induced COX-2 expression in all tested OSCCs.	Piroxicam	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-43
24631063-8	2014	Piroxicam inhibited Masitinib-induced COX-2 expression in all tested OSCCs.	masitinib	20-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-43
24882526-7	2014	In contrast to these reactions, the first reduction of the nitro-substituted porphyrins is macrocycle-centered under the same solution conditions and gives a Co(II) porphyrin pi-anion radical product.	nitro-substituted porphyrins	59-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	158-164
24882526-11	2014	Each neutral Co(II) porphyrin was also examined as to its catalytic activity for electroreduction of molecular oxygen when coated on an edge-plane pyrolytic graphite electrode in 1.0 M HClO4.	Oxygen	111-117	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-19
24756243-6	2014	Notably, the effect of DADS was largely abolished in the presence of either COX inhibitor indomethacin or siRNA-targeting COX-2, or in the absence of the PGE2 receptor EP2, supporting an essential role for the COX-2-PGE2-cAMP autocrine loop.	diallyl disulfide	23-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	210-220
24756243-6	2014	Notably, the effect of DADS was largely abolished in the presence of either COX inhibitor indomethacin or siRNA-targeting COX-2, or in the absence of the PGE2 receptor EP2, supporting an essential role for the COX-2-PGE2-cAMP autocrine loop.	Cyclic AMP	221-225	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	210-220
25024195-2	2014	COX-2 inhibitors, which block the formation of prostaglandins, suppress tumor growth, whereas sEH inhibitors, which increase endogenous EETs, stimulate primary tumor growth and metastasis.	Prostaglandins	47-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
24815057-0	2014	Synthesis and characterization of new transition metal {Cu(II), Ni(II) and Co(II)} L-phenylalanine-DACH conjugate complexes: in vitro DNA binding, cleavage and molecular docking studies.	cu(ii)	56-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-81
25034144-7	2014	Importantly, a positive correlation between the tissue amounts of Cr(III) and Co(II) ions and tissue oxidative damage was observed.	tris(1,10-phenanthroline)chromium(III) chloride	66-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-84
25034144-8	2014	Immobilized- Cr(III) and Co(II) affinity chromatography indicated that metal ions can also directly bind to several metallo and non-metalloproteins and, as demonstrated for aldolase and catalase, induce loss of their biological function.	Metals	71-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-31
25093007-21	2014	Taking an aspirin (ASA) regularly after being diagnosed with colon cancer is associated with less risk of dying from this cancer, especially among people who have tumors with COX-2 overexpression.16 Nonetheless, these data do not contradict the data obtained on a possible genetic predisposition, even in sporadic or non-hereditary CRC.	Aspirin	10-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	175-180
25093007-21	2014	Taking an aspirin (ASA) regularly after being diagnosed with colon cancer is associated with less risk of dying from this cancer, especially among people who have tumors with COX-2 overexpression.16 Nonetheless, these data do not contradict the data obtained on a possible genetic predisposition, even in sporadic or non-hereditary CRC.	Aspirin	19-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	175-180
24867695-6	2014	Furthermore, treatment with conventional chemotherapeutic drugs (e.g., gemcitabine and doxorubicin) or COX-2 inhibitor, celecoxib, sensitised the cells to 2-DG treatment.	Celecoxib	120-129	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-108
24867695-6	2014	Furthermore, treatment with conventional chemotherapeutic drugs (e.g., gemcitabine and doxorubicin) or COX-2 inhibitor, celecoxib, sensitised the cells to 2-DG treatment.	Deoxyglucose	155-159	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-108
24874483-8	2014	Concomitant reduction in COX-2 expression was statistically significant in the exemestane and celecoxib arm (P&lt;0.03) only.	exemestane	79-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-30
24874483-8	2014	Concomitant reduction in COX-2 expression was statistically significant in the exemestane and celecoxib arm (P&lt;0.03) only.	Celecoxib	94-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-30
24874483-10	2014	A combination of an aromatase inhibitor and celecoxib has significant biological effect and may be integrated into treatment of COX2-positive DCIS at high risk of recurrence.	Celecoxib	44-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	128-132
25000190-0	2014	Melatonin enhances the anti-tumor effect of fisetin by inhibiting COX-2/iNOS and NF-kappaB/p300 signaling pathways.	Melatonin	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-71
25000190-0	2014	Melatonin enhances the anti-tumor effect of fisetin by inhibiting COX-2/iNOS and NF-kappaB/p300 signaling pathways.	fisetin	44-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-71
25000190-7	2014	The combinational treatment of fisetin with melatonin increased the cleavage of PARP proteins, triggered more release of cytochrome-c from the mitochondrial inter-membrane, enhanced the inhibition of COX-2 and iNOS expression, repressed the nuclear localization of p300 and NF-kappaB proteins, and abrogated the binding of NF-kappaB on COX-2 promoter.	Melatonin	44-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	200-205
25000190-7	2014	The combinational treatment of fisetin with melatonin increased the cleavage of PARP proteins, triggered more release of cytochrome-c from the mitochondrial inter-membrane, enhanced the inhibition of COX-2 and iNOS expression, repressed the nuclear localization of p300 and NF-kappaB proteins, and abrogated the binding of NF-kappaB on COX-2 promoter.	Melatonin	44-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	336-341
25000190-8	2014	Thus, these results demonstrated that melatonin potentiated the anti-tumor effect of fisetin in melanoma cells by activating cytochrome-c-dependent apoptotic pathway and inhibiting COX-2/iNOS and NF-kappaB/p300 signaling pathways, and our study suggests the potential of such a combinational treatment of natural products in melanoma therapy.	Melatonin	38-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	181-186
25000190-8	2014	Thus, these results demonstrated that melatonin potentiated the anti-tumor effect of fisetin in melanoma cells by activating cytochrome-c-dependent apoptotic pathway and inhibiting COX-2/iNOS and NF-kappaB/p300 signaling pathways, and our study suggests the potential of such a combinational treatment of natural products in melanoma therapy.	fisetin	85-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	181-186
24815057-1	2014	The novel metal-based molecular entities {Cu(II), Ni(II) and Co(II)} 1-3, respectively were synthesized and characterized by elemental analysis and spectroscopic methods (IR, (1)H and (13)C NMR, EPR, UV-vis, ESI-MS and XRPD).	Metals	10-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-67
24682052-0	2014	Synthesis, spectral, electrochemical and X-ray single crystal studies on Ni(II) and Co(II) complexes derived from 1-benzoyl-3-(4-methylpyridin-2-yl) thiourea.	1-benzoyl-3-(4-methylpyridin-2-yl) thiourea	114-157	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-90
24682052-1	2014	1-Benzoyl-3-(4-methylpyridin-2-yl) thiourea ligand was coordinated with Ni(II) and Co(II) perchlorate salts to isolate complexes.	1-benzoyl-3-(4-methylpyridin-2-yl) thiourea	0-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-89
24699295-0	2014	Synthesis, characterization, biological activity of binuclear Co(II), Cu(II) and mononuclear Ni(II) complexes of bulky multi-dentate thiosemicarbazide.	thiosemicarbazide	133-150	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-68
24699295-3	2014	The isolated Ni(II) and Cu(II) complexes are square-planar while the Co(II) is tetrahedral.	Nickel(2+)	13-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-75
24815057-0	2014	Synthesis and characterization of new transition metal {Cu(II), Ni(II) and Co(II)} L-phenylalanine-DACH conjugate complexes: in vitro DNA binding, cleavage and molecular docking studies.	Metals	49-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-81
25107843-0	2014	The PI3K/Akt pathway in colitis associated colon cancer and its chemoprevention with celecoxib, a Cox-2 selective inhibitor.	Celecoxib	85-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-103
24674948-5	2014	Using this assay, we measured the steady-state kinetics of peptides representing the H4 histone tail and demonstrate that a C-terminally conjugated methylcoumarin enhances the catalytic efficiency of deacetylation catalyzed by cobalt(II)-bound histone deacetylase 8 [Co(II)-HDAC8] compared with peptide substrates containing a C-terminal carboxylate, amide, and tryptophan by 50-, 2.8-, and 2.3-fold, respectively.	Cobalt(2+)	227-237	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	267-279
24674948-5	2014	Using this assay, we measured the steady-state kinetics of peptides representing the H4 histone tail and demonstrate that a C-terminally conjugated methylcoumarin enhances the catalytic efficiency of deacetylation catalyzed by cobalt(II)-bound histone deacetylase 8 [Co(II)-HDAC8] compared with peptide substrates containing a C-terminal carboxylate, amide, and tryptophan by 50-, 2.8-, and 2.3-fold, respectively.	carboxylate	338-349	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	267-279
24674948-5	2014	Using this assay, we measured the steady-state kinetics of peptides representing the H4 histone tail and demonstrate that a C-terminally conjugated methylcoumarin enhances the catalytic efficiency of deacetylation catalyzed by cobalt(II)-bound histone deacetylase 8 [Co(II)-HDAC8] compared with peptide substrates containing a C-terminal carboxylate, amide, and tryptophan by 50-, 2.8-, and 2.3-fold, respectively.	Amides	351-356	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	267-279
24674948-5	2014	Using this assay, we measured the steady-state kinetics of peptides representing the H4 histone tail and demonstrate that a C-terminally conjugated methylcoumarin enhances the catalytic efficiency of deacetylation catalyzed by cobalt(II)-bound histone deacetylase 8 [Co(II)-HDAC8] compared with peptide substrates containing a C-terminal carboxylate, amide, and tryptophan by 50-, 2.8-, and 2.3-fold, respectively.	Tryptophan	362-372	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	267-279
24889552-2	2014	The construction of the pyridazine nucleus from one alkyne and two nitrile units is proposed to follow either a conventional organometallic mechanism or to be triggered by a single-electron transfer from a Co(II) species.	pyridazine	24-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	206-212
24646155-2	2014	Moreover, activation of enzymes, such as COX-2, may contribute to isoprostane formation.	Isoprostanes	66-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-46
24889552-2	2014	The construction of the pyridazine nucleus from one alkyne and two nitrile units is proposed to follow either a conventional organometallic mechanism or to be triggered by a single-electron transfer from a Co(II) species.	Alkynes	52-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	206-212
24889552-2	2014	The construction of the pyridazine nucleus from one alkyne and two nitrile units is proposed to follow either a conventional organometallic mechanism or to be triggered by a single-electron transfer from a Co(II) species.	Nitriles	67-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	206-212
24388008-0	2014	Safety risks for patients with aspirin-exacerbated respiratory disease after acute exposure to selective nonsteroidal anti-inflammatory drugs and COX-2 inhibitors: Meta-analysis of controlled clinical trials.	Aspirin	31-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	146-151
25006185-9	2014	Selective cox-2 inhibitors were associated with a modest increased hazard for cardiovascular events (hazard ratio, 1.13; 1.04-1.23; P=0.004 and celecoxib only: HR, 1.13; 1.01-1.27; P=0.031).	Celecoxib	144-153	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
25006185-10	2014	Among aspirin users, concomitant selective cox-2 inhibitor use was no longer associated with increased hazard for cardiovascular events.	Aspirin	6-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
25006185-11	2014	There was an increased risk for agents with cox-2&gt;cox-1 inhibition (HR, 1.17; 1.10-1.24; P&lt;0.001 and naproxen only: HR, 1.22; 1.12-1.34; P&lt;0.001).	Naproxen	107-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-49
25276196-2	2014	In this study, a group of recently synthesized chalcones, with the structure of 1,3-diarylprop-2-en-1-one having different COX-1 and/or COX-2 selectivities have been examined on human hepatocarcinoma (HepG2), lung carcinoma (A549), and breast adenocarcinoma (MCF-7) cell line, using Sulforhodamine B (SRB) assay.	Chalcones	47-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	136-141
24507930-4	2014	Each compound can undergo two metal-centered one-electron reductions leading to formation of Co(II) and Co(I) derivatives in CH2Cl2 or pyridine containing 0.1 M tetra-n-butylammonium perchlorate (TBAP).	Metals	30-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-99
25276196-6	2014	Our results show that the subgroup possessing p-azido COX-2 pharmacophore seems to be more cytotoxic, while the cells seem to show more acquired resistance to them and the subgroup possessing a p-MeSO2NH COX-2 pharmacophore is less cytotoxic, while the cells also acquire less resistance to them.	p-azido	46-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-59
25276196-6	2014	Our results show that the subgroup possessing p-azido COX-2 pharmacophore seems to be more cytotoxic, while the cells seem to show more acquired resistance to them and the subgroup possessing a p-MeSO2NH COX-2 pharmacophore is less cytotoxic, while the cells also acquire less resistance to them.	p-azido	46-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	204-209
25276196-6	2014	Our results show that the subgroup possessing p-azido COX-2 pharmacophore seems to be more cytotoxic, while the cells seem to show more acquired resistance to them and the subgroup possessing a p-MeSO2NH COX-2 pharmacophore is less cytotoxic, while the cells also acquire less resistance to them.	p-meso2nh	194-203	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-59
25276196-6	2014	Our results show that the subgroup possessing p-azido COX-2 pharmacophore seems to be more cytotoxic, while the cells seem to show more acquired resistance to them and the subgroup possessing a p-MeSO2NH COX-2 pharmacophore is less cytotoxic, while the cells also acquire less resistance to them.	p-meso2nh	194-203	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	204-209
24829218-8	2014	The effects of the NOD1 ligand iE-DAP were mediated via NFkappaB, as the NFkappaB inhibitor BAY 11-7082 significantly attenuated iE-DAP-induced expression and secretion of pro-inflammatory cytokines, COX2 gene expression and subsequent prostaglandin production, MMP9 expression and secretion and ICAM1 and VCAM1 gene expression and secretion.	3-(4-methylphenylsulfonyl)-2-propenenitrile	92-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	200-204
24507930-9	2014	Thin-layer UV-visible spectroelectrochemical measurements in CH2Cl2, 0.1 M TBAP demonstrate the occurrence of an equilibrium between a Co(III) pi-anion radical and a Co(II) derivative with an uncharged macrocycle after the first controlled potential reduction of the nitro-substituted corroles.	nitro	267-272	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	166-172
24507930-9	2014	Thin-layer UV-visible spectroelectrochemical measurements in CH2Cl2, 0.1 M TBAP demonstrate the occurrence of an equilibrium between a Co(III) pi-anion radical and a Co(II) derivative with an uncharged macrocycle after the first controlled potential reduction of the nitro-substituted corroles.	corrole	285-293	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	166-172
24507930-4	2014	Each compound can undergo two metal-centered one-electron reductions leading to formation of Co(II) and Co(I) derivatives in CH2Cl2 or pyridine containing 0.1 M tetra-n-butylammonium perchlorate (TBAP).	Methylene Chloride	125-131	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-99
24507930-4	2014	Each compound can undergo two metal-centered one-electron reductions leading to formation of Co(II) and Co(I) derivatives in CH2Cl2 or pyridine containing 0.1 M tetra-n-butylammonium perchlorate (TBAP).	pyridine	135-143	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-99
24507930-4	2014	Each compound can undergo two metal-centered one-electron reductions leading to formation of Co(II) and Co(I) derivatives in CH2Cl2 or pyridine containing 0.1 M tetra-n-butylammonium perchlorate (TBAP).	tetrabutylammonium	161-194	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-99
24507930-4	2014	Each compound can undergo two metal-centered one-electron reductions leading to formation of Co(II) and Co(I) derivatives in CH2Cl2 or pyridine containing 0.1 M tetra-n-butylammonium perchlorate (TBAP).	tetrabutylammonium	196-200	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-99
24507930-8	2014	The second reduction of the NO2Ph groups is irreversible and located at a potential which overlaps the Co(II)/Co(I) process of the compounds.	no2ph	28-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-109
24507930-9	2014	Thin-layer UV-visible spectroelectrochemical measurements in CH2Cl2, 0.1 M TBAP demonstrate the occurrence of an equilibrium between a Co(III) pi-anion radical and a Co(II) derivative with an uncharged macrocycle after the first controlled potential reduction of the nitro-substituted corroles.	Methylene Chloride	61-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	166-172
24507930-9	2014	Thin-layer UV-visible spectroelectrochemical measurements in CH2Cl2, 0.1 M TBAP demonstrate the occurrence of an equilibrium between a Co(III) pi-anion radical and a Co(II) derivative with an uncharged macrocycle after the first controlled potential reduction of the nitro-substituted corroles.	tetrabutylammonium	75-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	166-172
24802614-3	2014	METHODS: Prostate cancer LNCaP, 22Rv1, and PC3 cells were cultured and treated with the COX-2 inhibitors celecoxib and CAY10404.	Celecoxib	105-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-93
23371504-2	2014	Here we investigated the effect of eicosapentaenoic acid (EPA) on the proliferation of human non-small cell lung cancer A549 (COX-2 over-expressing) and H1299 (COX-2 null) cells as well as their xenograft models.	Eicosapentaenoic Acid	58-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-131
23371504-5	2014	Intriguingly, when COX-2 expression was reduced by siRNA or shRNA in A549 cells, the antiproliferative activity of EPA was reduced substantially compared to that of control siRNA or shRNA transfected A549 cells.	Eicosapentaenoic Acid	115-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-24
23371504-10	2014	Taken together, the results of our study suggest that the ability of EPA to generate PGE3 through the COX-2 enzyme might be critical for EPA-mediated tumor growth inhibition which is at least partly due to down-regulation of Akt phosphorylation by PGE3.	Eicosapentaenoic Acid	69-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-107
23371504-10	2014	Taken together, the results of our study suggest that the ability of EPA to generate PGE3 through the COX-2 enzyme might be critical for EPA-mediated tumor growth inhibition which is at least partly due to down-regulation of Akt phosphorylation by PGE3.	prostaglandin E3	85-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-107
23371504-10	2014	Taken together, the results of our study suggest that the ability of EPA to generate PGE3 through the COX-2 enzyme might be critical for EPA-mediated tumor growth inhibition which is at least partly due to down-regulation of Akt phosphorylation by PGE3.	Eicosapentaenoic Acid	137-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-107
23371504-10	2014	Taken together, the results of our study suggest that the ability of EPA to generate PGE3 through the COX-2 enzyme might be critical for EPA-mediated tumor growth inhibition which is at least partly due to down-regulation of Akt phosphorylation by PGE3.	prostaglandin E3	248-252	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-107
24469906-4	2014	Systemic and local drug concentrations, assessed by means of subcutaneous in-vivo microdialysis, were related to COX-2 inhibiting effects, quantified as inhibition of prostaglandin ex-vivo production in whole blood as well as local tissue prostaglandin (PG) concentrations.	Prostaglandins	167-180	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-118
24469906-4	2014	Systemic and local drug concentrations, assessed by means of subcutaneous in-vivo microdialysis, were related to COX-2 inhibiting effects, quantified as inhibition of prostaglandin ex-vivo production in whole blood as well as local tissue prostaglandin (PG) concentrations.	Prostaglandins	239-252	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-118
24469906-4	2014	Systemic and local drug concentrations, assessed by means of subcutaneous in-vivo microdialysis, were related to COX-2 inhibiting effects, quantified as inhibition of prostaglandin ex-vivo production in whole blood as well as local tissue prostaglandin (PG) concentrations.	Prostaglandins	254-256	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-118
24469906-7	2014	The local COX-2 inhibition by etoricoxib was most pronounced for PGD2.	Etoricoxib	30-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
24469906-7	2014	The local COX-2 inhibition by etoricoxib was most pronounced for PGD2.	Prostaglandin D2	65-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
24469906-9	2014	CONCLUSIONS: Doses of 50 mg lumiracoxib and 90 mg etoricoxib produced similar maximum inhibition of systemic COX-2 function whereas 50 mg lumiracoxib was ineffective in producing local COX-2 inhibition.	lumiracoxib	28-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-114
24469906-9	2014	CONCLUSIONS: Doses of 50 mg lumiracoxib and 90 mg etoricoxib produced similar maximum inhibition of systemic COX-2 function whereas 50 mg lumiracoxib was ineffective in producing local COX-2 inhibition.	Etoricoxib	50-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-114
25019142-4	2014	For instance, nonsteroidal anti-inflammatory agents (NSAIDs), both classical nonselective (cNSAIDs) and the selective COX-2 inhibitors (coxibs) attenuate the generation of PGH2 from AA that in turn reduces the synthesis of PGE2 and modifies the inflammatory conditions.	Prostaglandin H2	172-176	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-123
25019142-4	2014	For instance, nonsteroidal anti-inflammatory agents (NSAIDs), both classical nonselective (cNSAIDs) and the selective COX-2 inhibitors (coxibs) attenuate the generation of PGH2 from AA that in turn reduces the synthesis of PGE2 and modifies the inflammatory conditions.	Dinoprostone	223-227	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-123
25019142-6	2014	Microsomal prostaglandin E2 synthase-1 (mPGES-1), a downstream PG synthase, specifically catalyzes the biosynthesis of COX-2-derived PGE2 from PGH2, and describes itself as a valuable therapeutic target for the treatment of acute and chronic inflammatory disease conditions.	Prostaglandins	11-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-124
25019142-6	2014	Microsomal prostaglandin E2 synthase-1 (mPGES-1), a downstream PG synthase, specifically catalyzes the biosynthesis of COX-2-derived PGE2 from PGH2, and describes itself as a valuable therapeutic target for the treatment of acute and chronic inflammatory disease conditions.	Dinoprostone	133-137	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-124
25019142-6	2014	Microsomal prostaglandin E2 synthase-1 (mPGES-1), a downstream PG synthase, specifically catalyzes the biosynthesis of COX-2-derived PGE2 from PGH2, and describes itself as a valuable therapeutic target for the treatment of acute and chronic inflammatory disease conditions.	Prostaglandin H2	143-147	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-124
24910778-0	2014	Stereoselective Intramolecular Cyclopropanation of alpha-Diazoacetates via Co(II)-Based Metalloradical Catalysis.	alpha-diazoacetates	51-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-81
24910778-1	2014	Co(II) complexes of D2-symmetric chiral porphyrins have been proven to be effective metalloradical catalysts for the asymmetric intramolecular cyclopropanation of allyl alpha-diazoacetates.	alpha-diazoacetates	169-188	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
24802614-3	2014	METHODS: Prostate cancer LNCaP, 22Rv1, and PC3 cells were cultured and treated with the COX-2 inhibitors celecoxib and CAY10404.	3-(4-methylsulfonylphenyl)-4-phenyl-5-trifluoromethylisoxazole	119-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-93
24802614-8	2014	RESULTS: Treatment with the COX-2 inhibitors celecoxib and CAY10404 or knockdown of COX-2 significantly inhibited prostate cancer cell proliferation.	Celecoxib	45-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
24802614-8	2014	RESULTS: Treatment with the COX-2 inhibitors celecoxib and CAY10404 or knockdown of COX-2 significantly inhibited prostate cancer cell proliferation.	3-(4-methylsulfonylphenyl)-4-phenyl-5-trifluoromethylisoxazole	59-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
24970799-4	2014	We report that FYN phosphorylates human COX2 on Tyr 446, and while corresponding phospho-mimetic COX2 mutation promotes COX2 activity, the phosphorylation blocking mutation prevents FYN-mediated increase in COX2 activity.	Tyrosine	48-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-44
24970799-4	2014	We report that FYN phosphorylates human COX2 on Tyr 446, and while corresponding phospho-mimetic COX2 mutation promotes COX2 activity, the phosphorylation blocking mutation prevents FYN-mediated increase in COX2 activity.	Tyrosine	48-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-101
24970799-4	2014	We report that FYN phosphorylates human COX2 on Tyr 446, and while corresponding phospho-mimetic COX2 mutation promotes COX2 activity, the phosphorylation blocking mutation prevents FYN-mediated increase in COX2 activity.	Tyrosine	48-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-101
24970799-4	2014	We report that FYN phosphorylates human COX2 on Tyr 446, and while corresponding phospho-mimetic COX2 mutation promotes COX2 activity, the phosphorylation blocking mutation prevents FYN-mediated increase in COX2 activity.	Tyrosine	48-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-101
24888451-1	2014	Reaction of Co(II) with the nitrogen-rich ligand N,N-bis(1H-tetrazole-5-yl)-amine (H2bta) leads to a mixed-valence, 3D, porous, metal-organic framework (MOF)-based, energetic material with the nitrogen content of 51.78%, [Co9(bta)10(Hbta)2(H2O)10]n (22 H2O)n (1).	Nitrogen	28-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-18
24819564-1	2014	A homogeneous solution of Co(II) in acetate buffer at pH 7 is found to be an efficient water oxidation catalyst (WOC) showing significantly greater current density than Co(II) in phosphate buffer (Co-Pi) under identical conditions owing to the higher solubility of the former.	Acetates	36-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-32
24819564-1	2014	A homogeneous solution of Co(II) in acetate buffer at pH 7 is found to be an efficient water oxidation catalyst (WOC) showing significantly greater current density than Co(II) in phosphate buffer (Co-Pi) under identical conditions owing to the higher solubility of the former.	Water	87-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-32
24819564-1	2014	A homogeneous solution of Co(II) in acetate buffer at pH 7 is found to be an efficient water oxidation catalyst (WOC) showing significantly greater current density than Co(II) in phosphate buffer (Co-Pi) under identical conditions owing to the higher solubility of the former.	Phosphates	179-188	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-32
24819564-1	2014	A homogeneous solution of Co(II) in acetate buffer at pH 7 is found to be an efficient water oxidation catalyst (WOC) showing significantly greater current density than Co(II) in phosphate buffer (Co-Pi) under identical conditions owing to the higher solubility of the former.	Cobalt	26-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	169-175
24664104-0	2014	A Co(II)-Ru(II) dyad relevant to light-driven water oxidation catalysis.	Water	46-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	2-8
24888451-1	2014	Reaction of Co(II) with the nitrogen-rich ligand N,N-bis(1H-tetrazole-5-yl)-amine (H2bta) leads to a mixed-valence, 3D, porous, metal-organic framework (MOF)-based, energetic material with the nitrogen content of 51.78%, [Co9(bta)10(Hbta)2(H2O)10]n (22 H2O)n (1).	n,n-bis(1h-tetrazole-5-yl)-amine	49-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-18
24836072-0	2014	Synthesis of novel 2-mercaptobenzoxazole based 1,2,3-triazoles as inhibitors of proinflammatory cytokines and suppressors of COX-2 gene expression.	2-mercaptobenzoxazole	19-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-130
24888451-1	2014	Reaction of Co(II) with the nitrogen-rich ligand N,N-bis(1H-tetrazole-5-yl)-amine (H2bta) leads to a mixed-valence, 3D, porous, metal-organic framework (MOF)-based, energetic material with the nitrogen content of 51.78%, [Co9(bta)10(Hbta)2(H2O)10]n (22 H2O)n (1).	h2bta	83-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-18
24836072-0	2014	Synthesis of novel 2-mercaptobenzoxazole based 1,2,3-triazoles as inhibitors of proinflammatory cytokines and suppressors of COX-2 gene expression.	1,2,3-triazoles	47-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-130
24888451-1	2014	Reaction of Co(II) with the nitrogen-rich ligand N,N-bis(1H-tetrazole-5-yl)-amine (H2bta) leads to a mixed-valence, 3D, porous, metal-organic framework (MOF)-based, energetic material with the nitrogen content of 51.78%, [Co9(bta)10(Hbta)2(H2O)10]n (22 H2O)n (1).	Metals	128-133	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-18
24888451-1	2014	Reaction of Co(II) with the nitrogen-rich ligand N,N-bis(1H-tetrazole-5-yl)-amine (H2bta) leads to a mixed-valence, 3D, porous, metal-organic framework (MOF)-based, energetic material with the nitrogen content of 51.78%, [Co9(bta)10(Hbta)2(H2O)10]n (22 H2O)n (1).	Nitrogen	193-201	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-18
24888451-1	2014	Reaction of Co(II) with the nitrogen-rich ligand N,N-bis(1H-tetrazole-5-yl)-amine (H2bta) leads to a mixed-valence, 3D, porous, metal-organic framework (MOF)-based, energetic material with the nitrogen content of 51.78%, [Co9(bta)10(Hbta)2(H2O)10]n (22 H2O)n (1).	1-({2-[(1s)-1-Aminoethyl]-1,3-Oxazol-4-Yl}carbonyl)-L-Prolyl-L-Tryptophan	222-225	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-18
24888451-1	2014	Reaction of Co(II) with the nitrogen-rich ligand N,N-bis(1H-tetrazole-5-yl)-amine (H2bta) leads to a mixed-valence, 3D, porous, metal-organic framework (MOF)-based, energetic material with the nitrogen content of 51.78%, [Co9(bta)10(Hbta)2(H2O)10]n (22 H2O)n (1).	benzotriazole	85-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-18
24888451-1	2014	Reaction of Co(II) with the nitrogen-rich ligand N,N-bis(1H-tetrazole-5-yl)-amine (H2bta) leads to a mixed-valence, 3D, porous, metal-organic framework (MOF)-based, energetic material with the nitrogen content of 51.78%, [Co9(bta)10(Hbta)2(H2O)10]n (22 H2O)n (1).	hbta	233-237	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-18
24802678-9	2014	Marcus diagram is derived for the electron transfer reaction Co(II) + D35(+)  Co(III) + D35 using the Co-N bond length as a reaction coordinate.	co(iii)	78-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-67
24802678-9	2014	Marcus diagram is derived for the electron transfer reaction Co(II) + D35(+)  Co(III) + D35 using the Co-N bond length as a reaction coordinate.	co-n	102-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-67
24888451-1	2014	Reaction of Co(II) with the nitrogen-rich ligand N,N-bis(1H-tetrazole-5-yl)-amine (H2bta) leads to a mixed-valence, 3D, porous, metal-organic framework (MOF)-based, energetic material with the nitrogen content of 51.78%, [Co9(bta)10(Hbta)2(H2O)10]n (22 H2O)n (1).	Water	240-243	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-18
24888451-1	2014	Reaction of Co(II) with the nitrogen-rich ligand N,N-bis(1H-tetrazole-5-yl)-amine (H2bta) leads to a mixed-valence, 3D, porous, metal-organic framework (MOF)-based, energetic material with the nitrogen content of 51.78%, [Co9(bta)10(Hbta)2(H2O)10]n (22 H2O)n (1).	Water	253-256	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-18
24788679-1	2014	A significant improvement in the long-term stability for cobalt-based dye-sensitized solar cells (DSCs) under light-soaking conditions has been achieved by optimization of the composition of tris(2,2"-bipyridine) Co(ii)/Co(iii) electrolytes.	Cobalt	57-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	213-219
24861568-5	2014	The coordination of Co(II) in the porphyrin macrocycle is crucial and responsible for the formation of the required topology to trap CO2.	N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)-4-((4-fluorobenzyl)oxy)pyridine-2,6-dicarboxamide	133-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-26
24797689-0	2014	An unusual water-bridged homospin Co(II) single-chain magnet.	Water	11-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-40
24797689-1	2014	An unusual water-bridged homospin Co(II) coordination polymer has been successfully assembled, which exhibits slow relaxation of the magnetization at low temperature.	Water	11-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-40
24918932-6	2014	Interestingly, we observed that even chronic activation per se resulted in increased CD8+ T cell production of PGE2, mediated by higher COX-2 activity, thus inducing a negative feedback loop that further inhibits effector function.	Dinoprostone	111-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	136-141
24928142-0	2014	Peripheral administration of morphine attenuates postincisional pain by regulating macrophage polarization through COX-2-dependent pathway.	Morphine	29-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-120
24928142-11	2014	Conversely, cyclooxygenase (COX)-2, primarily produced from peripheral macrophages in acute inflammation states, was up-regulated in the early phase at morphine-injected sites.	Morphine	152-160	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-34
24928142-14	2014	A morphine-induced shift in macrophage phenotype may be mediated by a COX-2-dependent mechanism.	Morphine	2-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-75
24926985-4	2014	Capsaicin-treatment re-activated p53-SMAR1 positive feed-back loop in these cells to persuade p53-mediated HIF-1alpha degradation and SMAR1-induced repression of Cox-2 expression that restrained HIF-1alpha nuclear localization.	Capsaicin	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	162-167
24959102-2	2014	The combinations of retinoids and celecoxib as a COX-2 inhibitor were reported to be effective in some regimens of metronomic therapy of relapsed solid tumors with poor prognosis.	Retinoids	20-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-54
24959102-2	2014	The combinations of retinoids and celecoxib as a COX-2 inhibitor were reported to be effective in some regimens of metronomic therapy of relapsed solid tumors with poor prognosis.	Celecoxib	34-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-54
24959102-7	2014	Caffeic acid (an inhibitor of 5-LOX) and celecoxib (an inhibitor on COX-2) were used in combined treatment with ATRA.	Celecoxib	41-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-73
24705925-0	2014	A comparative synthetic, magnetic and theoretical study of functional M4Cl4 cubane-type Co(II) and Ni(II) complexes.	m4cl4	70-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-94
24794773-5	2014	Compound 15d appeared selectivity index (COX-2/COX-1) almost the half of celecoxib while 15c is non-selective for COX-2.	Celecoxib	73-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-46
24991280-0	2014	Synthesis of chiral N-phosphoryl aziridines through enantioselective aziridination of alkenes with phosphoryl azide via Co(II)-based metalloradical catalysis.	n-phosphoryl aziridines	20-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-125
24991280-0	2014	Synthesis of chiral N-phosphoryl aziridines through enantioselective aziridination of alkenes with phosphoryl azide via Co(II)-based metalloradical catalysis.	Alkenes	86-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-125
24991280-0	2014	Synthesis of chiral N-phosphoryl aziridines through enantioselective aziridination of alkenes with phosphoryl azide via Co(II)-based metalloradical catalysis.	phosphoryl azide	99-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-125
24991280-1	2014	The Co(II) complex of a new D 2-symmetric chiral porphyrin 3,5-DiMes-QingPhyrin, [Co(P6)], can catalyze asymmetric aziridination of alkenes with bis(2,2,2-trichloroethyl)phosphoryl azide (TcepN3) as a nitrene source.	porphyrin 3,5-dimes-qingphyrin	49-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
24901713-6	2014	Importantly, we found that sinomenine enhances the sensitivity of MDR-Caco-2 cells towards doxorubicin by downregulating MDR-1 and COX-2 expression through inhibition of the NF-kappaB signaling pathway.	sinomenine	27-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-136
24901713-6	2014	Importantly, we found that sinomenine enhances the sensitivity of MDR-Caco-2 cells towards doxorubicin by downregulating MDR-1 and COX-2 expression through inhibition of the NF-kappaB signaling pathway.	Doxorubicin	91-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-136
24991280-1	2014	The Co(II) complex of a new D 2-symmetric chiral porphyrin 3,5-DiMes-QingPhyrin, [Co(P6)], can catalyze asymmetric aziridination of alkenes with bis(2,2,2-trichloroethyl)phosphoryl azide (TcepN3) as a nitrene source.	co(p6)	82-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
24991280-1	2014	The Co(II) complex of a new D 2-symmetric chiral porphyrin 3,5-DiMes-QingPhyrin, [Co(P6)], can catalyze asymmetric aziridination of alkenes with bis(2,2,2-trichloroethyl)phosphoryl azide (TcepN3) as a nitrene source.	Alkenes	132-139	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
24991280-1	2014	The Co(II) complex of a new D 2-symmetric chiral porphyrin 3,5-DiMes-QingPhyrin, [Co(P6)], can catalyze asymmetric aziridination of alkenes with bis(2,2,2-trichloroethyl)phosphoryl azide (TcepN3) as a nitrene source.	bis(2,2,2-trichloroethyl)phosphoryl azide	145-186	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
24991280-1	2014	The Co(II) complex of a new D 2-symmetric chiral porphyrin 3,5-DiMes-QingPhyrin, [Co(P6)], can catalyze asymmetric aziridination of alkenes with bis(2,2,2-trichloroethyl)phosphoryl azide (TcepN3) as a nitrene source.	tcepn3	188-194	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
24991280-1	2014	The Co(II) complex of a new D 2-symmetric chiral porphyrin 3,5-DiMes-QingPhyrin, [Co(P6)], can catalyze asymmetric aziridination of alkenes with bis(2,2,2-trichloroethyl)phosphoryl azide (TcepN3) as a nitrene source.	phenylnitrene	201-208	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
24991280-2	2014	This new Co(II)-based metalloradical aziridination is suitable for different aromatic olefins, producing the corresponding N-phosphorylaziridines in good to excellent yields (up to 99%) with moderate to high enantioselectivities (up to 85% ee).	aromatic olefins	77-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	9-14
24991280-2	2014	This new Co(II)-based metalloradical aziridination is suitable for different aromatic olefins, producing the corresponding N-phosphorylaziridines in good to excellent yields (up to 99%) with moderate to high enantioselectivities (up to 85% ee).	n-phosphorylaziridines	123-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	9-14
25071929-0	2014	Selective Radical Amination of Aldehydic C(sp2)-H Bonds with Fluoroaryl Azides via Co(II)-Based Metalloradical Catalysis: Synthesis of N-Fluoroaryl Amides from Aldehydes under Neutral and Nonoxidative Conditions.	fluoroaryl azides	61-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
24520814-6	2014	KEY RESULTS: (E)-2,4-bis(p-hydroxyphenyl)-2-butenal (2.5-10 mug mL(-1) ) inhibited LPS-inducedNO generation, iNOS and COX2 expression, and NF-kappaB/IKK and STAT3 activities in macrophage and human synoviocytes.	SCHEMBL6784264	13-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-122
25071929-1	2014	The Co(II) complex of the D2h-symmetric amidoporphyrin 3,5-Di t Bu-IbuPhyrin, [Co(P1)], has proven to be an effective metalloradical catalyst for intermolecular amination of C(sp2)-H bonds of aldehydes with fluoroaryl azides.	fluoroaryl azides	207-224	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
24783984-6	2014	Special emphasis is given to the ability of aspirin to acetylate cyclooxygenases (especially COX-2) and thus to initiate a biochemical pathway leading to the generation of anti-inflammatory pro-resolving mediators synthesized from both omega-3 and omega-6 long-chain polyunsaturated fatty acids.	omega-6 long-chain polyunsaturated fatty acids	248-294	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-98
24721459-4	2014	This study evaluated the effect of celecoxib, a selective COX-2 inhibitor, on extracellular matrix (ECM) metabolism of mandibular condylar chondrocytes under CTS.	Celecoxib	35-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
24721459-8	2014	RESULTS: The presence of celecoxib normalized the release of PGE2 and diminished the CTS-induced COX-2, MMP-1, MMP-3, MMP-9 and ADAMTS-5 gene expressions while recovered the downregulated type II collagen and aggrecan gene expressions.	Celecoxib	25-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
25023354-2	2014	Activated platelets, in response to tissue damage, induce a proinflammatory program involving the aberrant expression of cyclooxygenase (COX)-2, which leads to increased tissue concentrations of the proinflammatory and protumorigenic prostaglandin E2.	Dinoprostone	234-250	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-143
24989281-0	2014	[Effect of COX-2 inhibitor celecoxib on proliferation, apoptosis of HL-60 cells and its mechanism].	Celecoxib	27-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-16
24989281-1	2014	This study was aimed to investigate the effect of COX-2 inhibitor celecoxib on proliferation, apoptosis of human acute myeloid leukemia cell line HL-60 and its mechanism.	Celecoxib	66-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-55
24989281-7	2014	It is concluded that celecoxib can inhibit the proliferation of HL-60 cells in dose-dependent manner, celecoxib causes cell G0/G1 arrest and induces cell apoptosis possibly through down-regulation of the cyclin D1 and cyclin E1 expression, and down-regulation of COX-2 expression respectively.	Celecoxib	21-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	263-268
24989281-7	2014	It is concluded that celecoxib can inhibit the proliferation of HL-60 cells in dose-dependent manner, celecoxib causes cell G0/G1 arrest and induces cell apoptosis possibly through down-regulation of the cyclin D1 and cyclin E1 expression, and down-regulation of COX-2 expression respectively.	Celecoxib	102-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	263-268
24710036-0	2014	A supramolecular Co(II)14-metal-organic cube in a hydrogen-bonded network and a Co(II)-organic framework with a flexible methoxy substituent.	Hydrogen	50-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22
24710036-1	2014	The reaction of 4,5-dicyano-2-methoxyimidazole (L1) with Co(NO3)2 6H2O under solvothermal conditions in DMF, a MOF, and a hydrogen-bonded network consisting of tetradecanuclear Co(ii)14-metal organic cube () are achieved.	2-methoxyimidazole-4,5-dicarbonitrile	16-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	177-182
24710036-1	2014	The reaction of 4,5-dicyano-2-methoxyimidazole (L1) with Co(NO3)2 6H2O under solvothermal conditions in DMF, a MOF, and a hydrogen-bonded network consisting of tetradecanuclear Co(ii)14-metal organic cube () are achieved.	Deferiprone	48-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	177-182
24710036-1	2014	The reaction of 4,5-dicyano-2-methoxyimidazole (L1) with Co(NO3)2 6H2O under solvothermal conditions in DMF, a MOF, and a hydrogen-bonded network consisting of tetradecanuclear Co(ii)14-metal organic cube () are achieved.	cobaltous nitrate	57-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	177-182
24710036-1	2014	The reaction of 4,5-dicyano-2-methoxyimidazole (L1) with Co(NO3)2 6H2O under solvothermal conditions in DMF, a MOF, and a hydrogen-bonded network consisting of tetradecanuclear Co(ii)14-metal organic cube () are achieved.	Hydrogen	122-130	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	177-182
24162794-0	2014	An unprecedented Co(II) cuboctahedron as the secondary building unit in a Co-based metal-organic framework.	Metals	83-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-23
24162794-2	2014	The obtained SBU is composed of 8 Co(II) ions at each vertex, 6 mu4-OH groups at each face, and 12 cpt(-) ligands framing the metal core.	sbu	13-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-40
24162794-4	2014	Magnetic measurements as well as DFT calculations on this crystalline MOF reveal intramolecular antiferromagnetic coupling between Co(II) ions in the octanuclear SBU.	sbu	162-165	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-137
24859347-0	2014	The involvement of NFAT transcriptional activity suppression in SIRT1-mediated inhibition of COX-2 expression induced by PMA/Ionomycin.	Tetradecanoylphorbol Acetate	121-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-98
24859347-0	2014	The involvement of NFAT transcriptional activity suppression in SIRT1-mediated inhibition of COX-2 expression induced by PMA/Ionomycin.	Ionomycin	125-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-98
24859347-8	2014	Adenoviral over-expression of SIRT1 suppressed PMA and calcium ionophore Ionomycin (PMA/Io)-induced COX-2 expression in human umbilical vein endothelial cells (HUVECs), while SIRT1 RNAi reversed the effects in HUVECs.	Calcium	55-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-105
24859347-8	2014	Adenoviral over-expression of SIRT1 suppressed PMA and calcium ionophore Ionomycin (PMA/Io)-induced COX-2 expression in human umbilical vein endothelial cells (HUVECs), while SIRT1 RNAi reversed the effects in HUVECs.	Ionomycin	73-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-105
24754678-3	2014	This marks the first preparation of a metallo-beta-lactamase selectively substituted with a paramagnetic metal ion, Co(II), either in the Zn1 (CoCd-NDM-1) or in the Zn2 site (ZnCo-NDM-1), as well as both (CoCo-NDM-1).	Metals	38-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-122
24614081-8	2014	Our findings demonstrate the involvement of COX-2 in the genesis of CSFTCs and suggest that COX-2 inhibitors should be investigated in patients with breast cancer with brain metastases for their ability to reduce CSFTC counts and prevent systemic recurrence.	csftc	68-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-49
24697248-2	2014	This risk seems to be related to the COX-2 inhibitory potency and has been found with most NSAIDs except naproxen.	Naproxen	105-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-42
24697248-3	2014	Two main hypotheses have been advanced: an imbalance between COX-1-dependent platelet production of thromboxane and partly COX-2-dependent endothelial production of prostacyclin, and a COX-2-dependent increase in blood pressure.	Epoprostenol	165-177	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-128
24474408-0	2014	Effect of a selective COX-2 inhibitor, celecoxib, on heterotopic ossification after total hip arthroplasty: a case-controlled study.	Celecoxib	39-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-27
24474408-2	2014	In this study, we examined the effect of the selective COX-2 inhibitor, celecoxib, on the rates of HO after THA.	Celecoxib	72-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-60
24589569-6	2014	Moreover, TET attenuated expression of cyclooxygenase (COX)-2.	tetrandrine	10-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-61
24589569-9	2014	Furthermore, TET suppressed the expression of TNF-alpha, IL-8, IL-6 and COX-2 through suppression of the ERK1/2, JNK1/2, IkappaBalpha degradation and phosphorylation, and NF-kappaB activation.	tetrandrine	13-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
24783984-6	2014	Special emphasis is given to the ability of aspirin to acetylate cyclooxygenases (especially COX-2) and thus to initiate a biochemical pathway leading to the generation of anti-inflammatory pro-resolving mediators synthesized from both omega-3 and omega-6 long-chain polyunsaturated fatty acids.	Aspirin	44-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-98
24783984-6	2014	Special emphasis is given to the ability of aspirin to acetylate cyclooxygenases (especially COX-2) and thus to initiate a biochemical pathway leading to the generation of anti-inflammatory pro-resolving mediators synthesized from both omega-3 and omega-6 long-chain polyunsaturated fatty acids.	omega-3	236-243	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-98
24699315-8	2014	IMPLICATIONS: Cholangiocarcinogenesis and tumor progression are regulated by a novel interplay between COX-2/PGE2 and miR-21 signaling, which converges at 15-PGDH.	Dinoprostone	109-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-108
24638056-2	2014	In order to understand cell proliferation and its association with COX-2 in HepG2 cells in the presence of ursolic acid (UA), viili exopolysaccharides (VEPS) and Astragalus polysaccharides (APS), the cell proliferation, superoxide dismutase (SOD) and metabolic malondialdehyde (MDA) of fatty acids, COX-2, prostaglandin E2 (PGE2), as well as apoptotic morphology and rate were investigated.	Polysaccharides	135-150	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-72
24721459-8	2014	RESULTS: The presence of celecoxib normalized the release of PGE2 and diminished the CTS-induced COX-2, MMP-1, MMP-3, MMP-9 and ADAMTS-5 gene expressions while recovered the downregulated type II collagen and aggrecan gene expressions.	castanospermine	85-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
24719198-2	2014	We report herein a mononuclear dithiolate Co(III) complex, [Co(III)LS(Cl)] (1; LS=sulfur containing ligand), that undergoes a clean, fast, quantitative and reversible Co(II) disulfide/Co(III) thiolate interconversion mediated by a chloride anion.	dithiolate	31-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	167-173
24719198-2	2014	We report herein a mononuclear dithiolate Co(III) complex, [Co(III)LS(Cl)] (1; LS=sulfur containing ligand), that undergoes a clean, fast, quantitative and reversible Co(II) disulfide/Co(III) thiolate interconversion mediated by a chloride anion.	Sulfur	82-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	167-173
24719198-2	2014	We report herein a mononuclear dithiolate Co(III) complex, [Co(III)LS(Cl)] (1; LS=sulfur containing ligand), that undergoes a clean, fast, quantitative and reversible Co(II) disulfide/Co(III) thiolate interconversion mediated by a chloride anion.	Chlorides	231-239	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	167-173
24779588-7	2014	In turn, magnetic properties of the Fe2CoO(Piv)6 unit were fitted using two models, one of which directly took into account a spin-orbit coupling of Co(II), and in the second model the spin-orbit coupling of Co(II) was approximated as zero-field splitting.	fe2coo	36-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	149-154
24779588-7	2014	In turn, magnetic properties of the Fe2CoO(Piv)6 unit were fitted using two models, one of which directly took into account a spin-orbit coupling of Co(II), and in the second model the spin-orbit coupling of Co(II) was approximated as zero-field splitting.	fe2coo	36-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	149-155
24845412-0	2014	Lasiodin inhibits proliferation of human nasopharyngeal carcinoma cells by simultaneous modulation of the Apaf-1/caspase, AKT/MAPK and COX-2/NF-kappaB signaling pathways.	lasiodin	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-140
24845412-9	2014	Moreover, the treatment with lasiodin inhibited the COX-2 expression, abrogated NF-kappaB binding to the COX-2 promoter, and promoted the NF-kappaB translocation from cell nuclei to cytosol.	lasiodin	29-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-57
24845412-9	2014	Moreover, the treatment with lasiodin inhibited the COX-2 expression, abrogated NF-kappaB binding to the COX-2 promoter, and promoted the NF-kappaB translocation from cell nuclei to cytosol.	lasiodin	29-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-110
24845412-10	2014	The pretreatment with a COX-2-selective inhibitor abrogated the lasiodin-induced inhibition of cell proliferation.	lasiodin	64-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
24845412-11	2014	These results indicated that lasiodin simultaneously activated the Apaf-1/caspase-dependent apoptotic pathways and suppressed the AKT/MAPK and COX-2/NF-kappaB signaling pathways.	lasiodin	29-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	143-148
24700242-1	2014	The cobalt(II) anilinosalen complex [Co(II)(L)] was prepared and subsequently oxidized by one electron.	cobalt(ii) anilinosalen	4-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-43
24700242-2	2014	The resulting cation comprises a square planar low spin Co(II) ion anti-ferromagnetically exchange coupled to an anilinyl radical.	anilinyl radical	113-129	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-62
24842612-10	2014	These studies for the first time define a link between tumor COX-2 induction, PGE2 production and expression of TREM-1 in macrophages in tumor microenvironment and suggest that TREM-1 might be a novel target for tumor immunomodulation.	Dinoprostone	78-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-66
24637636-0	2014	COX-2-independent effects of celecoxib sensitize lymphoma B cells to TRAIL-mediated apoptosis.	Celecoxib	29-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
24637636-5	2014	This production is abrogated after celecoxib treatment, targeting the COX-2 isoenzyme involved in PGE2 synthesis.	Celecoxib	35-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-75
24637636-5	2014	This production is abrogated after celecoxib treatment, targeting the COX-2 isoenzyme involved in PGE2 synthesis.	Dinoprostone	98-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-75
24637636-8	2014	We provide evidence that celecoxib affects proliferation and sensitizes NHL B-cell lines to apoptosis through COX-2-independent effects by slowing down the cell cycle and decreasing the expression of survival proteins, such as Mcl-1.	Celecoxib	25-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-115
24830713-3	2014	The results demonstrated that some derivatives of benzothieno[3,2-d] pyrimidine exhibit interesting anti-inflammatory properties related to interactions with active sites of COX-2 and are fluorescent.	benzothieno[3,2-d] pyrimidine	50-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	174-179
24763687-3	2014	Importantly, PPARdelta is required for dextran sodium sulfate induction of proinflammatory mediators, including chemokines, cytokines, COX-2, and prostaglandin E2 (PGE2), in vivo.	dextran sodium sulfate	39-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-140
24763687-5	2014	COX-2-derived PGE2 stimulates macrophages to produce proinflammatory chemokines and cytokines that are responsible for recruitment of leukocytes from the circulation to local sites of inflammation.	Dinoprostone	14-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
24763687-6	2014	Our results suggest that PPARdelta promotes colonic inflammation and colitis-associated tumor growth via the COX-2-derived PGE2 signaling axis that mediates cross-talk between tumor epithelial cells and macrophages.	Dinoprostone	123-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-114
26580539-2	2014	Cob(II)alamin is an intermediate which participates in many reactions catalyzed by derivatives of vitamin B12 and that can be detected by EPR spectroscopy due to the presence of the paramagnetic Co(II)(d(7)) center.	cob(II)alamin	0-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	195-201
26580539-2	2014	Cob(II)alamin is an intermediate which participates in many reactions catalyzed by derivatives of vitamin B12 and that can be detected by EPR spectroscopy due to the presence of the paramagnetic Co(II)(d(7)) center.	Vitamin B 12	98-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	195-201
24815497-10	2014	Selective COX-2 inhibition abrogated the IH-induced MAP increase (P=0.19), but resulted in lower post-IH CBF (P=0.01).	Ile-His	41-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
24826080-1	2014	BACKGROUND: Cyclooxygenase (COX) is a rate-limiting enzyme in prostaglandins synthesis which exists in two isoforms, COX-1 and COX-2.	Prostaglandins	62-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	127-132
24796327-6	2014	RESULTS: The half-maximal inhibitory concentration (IC50) of diclofenac, bromfenac, and amfenac was 55.5, 5.56, and 15.3 nM for human COX-1, and 30.7, 7.45, and 20.4 nM for human COX-2, respectively.	Diclofenac	61-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	179-184
24796327-6	2014	RESULTS: The half-maximal inhibitory concentration (IC50) of diclofenac, bromfenac, and amfenac was 55.5, 5.56, and 15.3 nM for human COX-1, and 30.7, 7.45, and 20.4 nM for human COX-2, respectively.	bromfenac	73-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	179-184
24796327-6	2014	RESULTS: The half-maximal inhibitory concentration (IC50) of diclofenac, bromfenac, and amfenac was 55.5, 5.56, and 15.3 nM for human COX-1, and 30.7, 7.45, and 20.4 nM for human COX-2, respectively.	amfenac	88-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	179-184
24705122-1	2014	Our previous studies have shown that quercetin inhibits Cox-2 and Bcl-2 expressions, and induces human leukemia HL-60 cell apoptosis.	Quercetin	37-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-61
24705122-4	2014	The expressions of LKB1, p-AMPK, and Cox-2 were detected in HL-60 cells after culture with quercetin.	Quercetin	91-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-42
24705122-5	2014	The expressions of p-AMPK were detected in HL-60 cells after culture with AMPK inhibitor Compound C. Then, the expressions of LKB1, p-AMPK, and Cox-2 were detected in HL-60 cells after culture with quercetin alone or quercetin + Compound C. It was found that there was no significant difference in LKB1 between PBMCs and HL-60.	Quercetin	198-207	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	144-149
24705122-5	2014	The expressions of p-AMPK were detected in HL-60 cells after culture with AMPK inhibitor Compound C. Then, the expressions of LKB1, p-AMPK, and Cox-2 were detected in HL-60 cells after culture with quercetin alone or quercetin + Compound C. It was found that there was no significant difference in LKB1 between PBMCs and HL-60.	Quercetin	217-226	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	144-149
24705122-7	2014	After culture of HL-60 with quercetin, p-AMPK was increased, Cox-2 was decreased, but LKB1 remained unchanged.	Quercetin	28-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-66
24705122-10	2014	p-AMPK decreased more significantly, while Cox-2 increased more significantly in the quercetin + Compound C groups than those in the quercetin-alone groups.	Quercetin	85-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
24705122-11	2014	Taken together, these findings suggested that quercetin activates AMPK expression in HL-60 cells independent of LKB1 activation, inhibits Cox-2 expression by activating AMPK, and further regulates the Bcl-2-dependent pathways of apoptosis to exert its anti-leukemia effect.	Quercetin	46-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	138-143
24816026-1	2014	Two different one-dimensional supramolecular chains with Co(II) cations have been synthesized based on the semi-rigid ligand 2-[1-(pyridin-4-ylmethyl)-1H-benzimidazol-2-yl]quinoline (L), obtained by condensation of 2-(1H-benzimidazol-2-yl)quinoline and 4-(chloromethyl)pyridine hydrochloride.	2-(1-(pyridin-4-ylmethyl)-1H-benzimidazol-2-yl)quinoline	125-181	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-63
24816026-1	2014	Two different one-dimensional supramolecular chains with Co(II) cations have been synthesized based on the semi-rigid ligand 2-[1-(pyridin-4-ylmethyl)-1H-benzimidazol-2-yl]quinoline (L), obtained by condensation of 2-(1H-benzimidazol-2-yl)quinoline and 4-(chloromethyl)pyridine hydrochloride.	2-(1H-Benzo[d]imidazol-2-yl)quinoline	215-248	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-63
24816026-1	2014	Two different one-dimensional supramolecular chains with Co(II) cations have been synthesized based on the semi-rigid ligand 2-[1-(pyridin-4-ylmethyl)-1H-benzimidazol-2-yl]quinoline (L), obtained by condensation of 2-(1H-benzimidazol-2-yl)quinoline and 4-(chloromethyl)pyridine hydrochloride.	4-(Chloromethyl)pyridine hydrochloride	253-291	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-63
24816026-4	2014	In (I), the Co(II) centres lie in a distorted octahedral [CoN3O3] coordination environment.	con3o3	58-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-17
24816026-7	2014	In (II), the Co(II) centres lie in a distorted trigonal-bipyramidal [CoCl2N3] coordination environment.	cocl2n3	69-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
24375908-5	2014	When the cells were treated with LPA, the level of mRNA of COX-2 but not COX-1 was upregulated.	lysophosphatidic acid	33-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-64
24603988-5	2014	The induction of apoptosis by PM was associated with the inhibition of the pro-survival Akt, NF-kappaB and mTOR signaling proteins and their downstream intermediaries such as Foxo-3alpha and cyclin D1 (Akt); Cox-2 and VEGF (NF-kappaB); p-S6K1 and p-4E-BP1 (mTOR) as well as PKCepsilon.	pristimerin	30-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	208-213
25071929-0	2014	Selective Radical Amination of Aldehydic C(sp2)-H Bonds with Fluoroaryl Azides via Co(II)-Based Metalloradical Catalysis: Synthesis of N-Fluoroaryl Amides from Aldehydes under Neutral and Nonoxidative Conditions.	n-fluoroaryl amides	135-154	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
25071929-0	2014	Selective Radical Amination of Aldehydic C(sp2)-H Bonds with Fluoroaryl Azides via Co(II)-Based Metalloradical Catalysis: Synthesis of N-Fluoroaryl Amides from Aldehydes under Neutral and Nonoxidative Conditions.	Aldehydes	160-169	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
25071929-1	2014	The Co(II) complex of the D2h-symmetric amidoporphyrin 3,5-Di t Bu-IbuPhyrin, [Co(P1)], has proven to be an effective metalloradical catalyst for intermolecular amination of C(sp2)-H bonds of aldehydes with fluoroaryl azides.	amidoporphyrin 3,5-di t bu-ibuphyrin	40-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
25071929-1	2014	The Co(II) complex of the D2h-symmetric amidoporphyrin 3,5-Di t Bu-IbuPhyrin, [Co(P1)], has proven to be an effective metalloradical catalyst for intermolecular amination of C(sp2)-H bonds of aldehydes with fluoroaryl azides.	Aldehydes	192-201	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
24682422-6	2014	The anandamide-induced relaxation was virtually abolished by removal of the endothelium and strongly attenuated by inhibitors of cyclooxygenases (indomethacin, COX-1/COX-2, and nimesulide, COX-2), nitric oxide synthase (N (G) -nitro-L-arginine methyl ester) given separately or in combination, FAAH (URB597), and the prostanoid IP receptor antagonist, RO1138452.	anandamide	4-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	166-171
24849444-4	2014	RESULTS: Compared with the negative and blank control groups, COX-2 siRNA transfection resulted in significant growth inhibition of KB/VCR cells exposed to vincristine (P&lt;0.01), down-regulated the expressions of COX-2 and MDR-1 mRNAs, and obviously increased Rho-123 accumulation in KB/VCR cells.	Vincristine	156-167	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
24849444-5	2014	CONCLUSION: COX-2 gene silencing can enhance the chemosensitivity of KB/VCR cells to vincristine, the mechanism of which may involve down-regulated MDR-1 gene expression and inhibition of P-glycoprotein activity.	Vincristine	85-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-17
24646146-3	2014	The reduction of inadvertently oxidized corrinoids ([Co(II) ]-state) is catalysed in an ATP-dependent reaction by RACE proteins, the reductive activators of corrinoid-dependent enzymes.	Adenosine Triphosphate	88-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-59
24646146-3	2014	The reduction of inadvertently oxidized corrinoids ([Co(II) ]-state) is catalysed in an ATP-dependent reaction by RACE proteins, the reductive activators of corrinoid-dependent enzymes.	Corrinoids	40-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-59
24646146-7	2014	ATP hydrolysis was significantly stimulated by the corrinoid protein in the [Co(II) ]-state of the corrinoid cofactor.	Adenosine Triphosphate	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-83
24646146-7	2014	ATP hydrolysis was significantly stimulated by the corrinoid protein in the [Co(II) ]-state of the corrinoid cofactor.	Corrinoids	51-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-83
24682422-6	2014	The anandamide-induced relaxation was virtually abolished by removal of the endothelium and strongly attenuated by inhibitors of cyclooxygenases (indomethacin, COX-1/COX-2, and nimesulide, COX-2), nitric oxide synthase (N (G) -nitro-L-arginine methyl ester) given separately or in combination, FAAH (URB597), and the prostanoid IP receptor antagonist, RO1138452.	anandamide	4-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	189-194
24644094-1	2014	Coordination of a [Co(hfac)2] moiety (hfac = hexafluoroacetylacetonate) with a nitronylnitroxide radical linked to bulky, rigid pyrene (PyrNN) gives a helical 1:1 chain complex, in which both oxygen atoms of the radical NO( ) groups are bonded to Co(II) ions with strong antiferromagnetic exchange.	co(hfac)2	19-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	247-253
24603952-7	2014	The responsible mechanism is at least partially due to TQ inhibiting the growth of CCA cell lines induced by downregulation of PI3K/Akt and NF-kappaB and regulated gene products, including p-AKT, p65, XIAP, Bcl-2, COX-2, VEGF.	thymoquinone	55-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	214-219
24611712-5	2014	Using this method, dual-target inhibitors for COX-2 and LTA4H were designed, with the most potent one inhibiting PGE2 and LTB4 production in the human whole blood assay with IC50 values of 7.0 and 7.1 muM, respectively.	Dinoprostone	113-117	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
24644094-1	2014	Coordination of a [Co(hfac)2] moiety (hfac = hexafluoroacetylacetonate) with a nitronylnitroxide radical linked to bulky, rigid pyrene (PyrNN) gives a helical 1:1 chain complex, in which both oxygen atoms of the radical NO( ) groups are bonded to Co(II) ions with strong antiferromagnetic exchange.	nitronylnitroxide radical	79-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	247-253
24644094-1	2014	Coordination of a [Co(hfac)2] moiety (hfac = hexafluoroacetylacetonate) with a nitronylnitroxide radical linked to bulky, rigid pyrene (PyrNN) gives a helical 1:1 chain complex, in which both oxygen atoms of the radical NO( ) groups are bonded to Co(II) ions with strong antiferromagnetic exchange.	pyrene	128-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	247-253
24644094-1	2014	Coordination of a [Co(hfac)2] moiety (hfac = hexafluoroacetylacetonate) with a nitronylnitroxide radical linked to bulky, rigid pyrene (PyrNN) gives a helical 1:1 chain complex, in which both oxygen atoms of the radical NO( ) groups are bonded to Co(II) ions with strong antiferromagnetic exchange.	pyrnn)	136-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	247-253
24644094-1	2014	Coordination of a [Co(hfac)2] moiety (hfac = hexafluoroacetylacetonate) with a nitronylnitroxide radical linked to bulky, rigid pyrene (PyrNN) gives a helical 1:1 chain complex, in which both oxygen atoms of the radical NO( ) groups are bonded to Co(II) ions with strong antiferromagnetic exchange.	hexafluoro-acetylacetone	22-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	247-253
24644094-1	2014	Coordination of a [Co(hfac)2] moiety (hfac = hexafluoroacetylacetonate) with a nitronylnitroxide radical linked to bulky, rigid pyrene (PyrNN) gives a helical 1:1 chain complex, in which both oxygen atoms of the radical NO( ) groups are bonded to Co(II) ions with strong antiferromagnetic exchange.	hexafluoroacetylacetonate	45-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	247-253
24589710-1	2014	Linear trimetallic Co(III)/Co(II)/Co(III) cobalt complexes with bridging acyl-alkoxy ligands are electrocatalysts for the reduction of tosic acid in acetonitrile.	trimetallic	7-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-33
24577223-0	2014	Solvents and auxiliary ligands co-regulate three antiferromagnetic Co(II) MOFs based on a semi-rigid carboxylate ligand.	carboxylate	101-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-72
24525159-3	2014	When used as an adsorbent, the GO-NH2 demonstrated a very quick adsorption property for the removal of Co(II) ions, more than 90% of Co(II) ions could be removed within 5 min for dilute solutions at 0.3g/L adsorbent dose.	go-nh2	31-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-109
24525159-3	2014	When used as an adsorbent, the GO-NH2 demonstrated a very quick adsorption property for the removal of Co(II) ions, more than 90% of Co(II) ions could be removed within 5 min for dilute solutions at 0.3g/L adsorbent dose.	go-nh2	31-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	133-139
24525159-5	2014	The thermodynamic parameters calculated from temperature-dependent adsorption isotherms suggested that the Co(II) ions adsorption on GO-NH2 was a spontaneous process.	go-nh2	133-139	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-113
24525159-7	2014	Membrane filtration experiments revealed that the removal capabilities of the materials for cobalt ions depended on the membrane"s thickness, flow rate and initial concentration of Co(II) ions.	Cobalt	92-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	181-187
24496095-3	2014	Particularly, the central Mn(III) ion in MnCl(DPyP) was transmetallated with Co(II) or Zn(II) ions and the central Co(II) or Zn(II) ions were further coordinated to pyridyl groups of neighboring M(DPyP) (M = Co or Zn) porphyrin complexes.	manganese(III) acetate dihydrate	26-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-83
24496095-3	2014	Particularly, the central Mn(III) ion in MnCl(DPyP) was transmetallated with Co(II) or Zn(II) ions and the central Co(II) or Zn(II) ions were further coordinated to pyridyl groups of neighboring M(DPyP) (M = Co or Zn) porphyrin complexes.	manganese(III) acetate dihydrate	26-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-121
24496095-3	2014	Particularly, the central Mn(III) ion in MnCl(DPyP) was transmetallated with Co(II) or Zn(II) ions and the central Co(II) or Zn(II) ions were further coordinated to pyridyl groups of neighboring M(DPyP) (M = Co or Zn) porphyrin complexes.	mncl	41-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-83
24496095-3	2014	Particularly, the central Mn(III) ion in MnCl(DPyP) was transmetallated with Co(II) or Zn(II) ions and the central Co(II) or Zn(II) ions were further coordinated to pyridyl groups of neighboring M(DPyP) (M = Co or Zn) porphyrin complexes.	mncl	41-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-121
24496095-3	2014	Particularly, the central Mn(III) ion in MnCl(DPyP) was transmetallated with Co(II) or Zn(II) ions and the central Co(II) or Zn(II) ions were further coordinated to pyridyl groups of neighboring M(DPyP) (M = Co or Zn) porphyrin complexes.	1,3-di-(1-pyrenyl)propane	46-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-83
24496095-3	2014	Particularly, the central Mn(III) ion in MnCl(DPyP) was transmetallated with Co(II) or Zn(II) ions and the central Co(II) or Zn(II) ions were further coordinated to pyridyl groups of neighboring M(DPyP) (M = Co or Zn) porphyrin complexes.	1,3-di-(1-pyrenyl)propane	46-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-121
24496095-3	2014	Particularly, the central Mn(III) ion in MnCl(DPyP) was transmetallated with Co(II) or Zn(II) ions and the central Co(II) or Zn(II) ions were further coordinated to pyridyl groups of neighboring M(DPyP) (M = Co or Zn) porphyrin complexes.	1,3-di-(1-pyrenyl)propane	197-201	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-121
24496095-3	2014	Particularly, the central Mn(III) ion in MnCl(DPyP) was transmetallated with Co(II) or Zn(II) ions and the central Co(II) or Zn(II) ions were further coordinated to pyridyl groups of neighboring M(DPyP) (M = Co or Zn) porphyrin complexes.	zn) porphyrin	214-227	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-121
24589710-1	2014	Linear trimetallic Co(III)/Co(II)/Co(III) cobalt complexes with bridging acyl-alkoxy ligands are electrocatalysts for the reduction of tosic acid in acetonitrile.	Cobalt	42-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-33
24589710-1	2014	Linear trimetallic Co(III)/Co(II)/Co(III) cobalt complexes with bridging acyl-alkoxy ligands are electrocatalysts for the reduction of tosic acid in acetonitrile.	4-toluenesulfonic acid	135-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-33
24589710-1	2014	Linear trimetallic Co(III)/Co(II)/Co(III) cobalt complexes with bridging acyl-alkoxy ligands are electrocatalysts for the reduction of tosic acid in acetonitrile.	acetonitrile	149-161	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-33
24673361-3	2014	When exposed to O2, it transformed from an EPR inactive to an EPR active species indicative of oxidation of Co(I) to Co(II) with the formation of H2O2.	Oxygen	16-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-123
24673361-3	2014	When exposed to O2, it transformed from an EPR inactive to an EPR active species indicative of oxidation of Co(I) to Co(II) with the formation of H2O2.	Hydrogen Peroxide	146-150	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-123
24604763-4	2014	The initially formed states of 1 a and 3 a are considered to result from metal-to-polyoxometalate charge transfer (MPCT) from Co(II) to W, while the longer-lived excited state of 1 a is tentatively assigned to a localized intermediate MPCT state.	Metals	73-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-132
24604763-4	2014	The initially formed states of 1 a and 3 a are considered to result from metal-to-polyoxometalate charge transfer (MPCT) from Co(II) to W, while the longer-lived excited state of 1 a is tentatively assigned to a localized intermediate MPCT state.	Tungsten	136-137	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-132
24604763-5	2014	The excited state formed by the tetrahedral cobalt(II) centered heteropolyanion (1 a) is far longer-lived (tau=420 ps in H2 O; tau=1700 ps in MeCN) than that of 3 a (tau=1.3 ps), in which the single Co(II) atom is located in a pseudo-octahedral addendum site.	Cobalt(2+)	44-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	199-205
24463219-7	2014	The Co(II) complex of L(3)H2 has shown approximately %50 apoptotic effect at 10muM concentration.	l(3)h2	22-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
24562186-0	2014	Outer Co(II) ions in Co-ZIF-67 reversibly adsorb oxygen from both gas phase and liquid water.	Oxygen	49-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	6-12
24562186-0	2014	Outer Co(II) ions in Co-ZIF-67 reversibly adsorb oxygen from both gas phase and liquid water.	Water	87-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	6-12
24562186-1	2014	Outer Co(II) species in Co-ZIF-67 coordinate molecular oxygen both from the gas phase and liquid water, through an adsorption process (presumably yielding in both cases surface superoxo species), respectively weak and reversible (gas phase), and strong and irreversible (liquid); in the latter case desorption is however brought about by illumination with solar light comprising the UV component.	Oxygen	55-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	6-12
24562186-1	2014	Outer Co(II) species in Co-ZIF-67 coordinate molecular oxygen both from the gas phase and liquid water, through an adsorption process (presumably yielding in both cases surface superoxo species), respectively weak and reversible (gas phase), and strong and irreversible (liquid); in the latter case desorption is however brought about by illumination with solar light comprising the UV component.	Water	97-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	6-12
24635104-2	2014	The ligand readily accommodates Co(II) bearing two axial chlorides, and the resulting complex is reasonably soluble in water.	Chlorides	57-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-38
24635104-2	2014	The ligand readily accommodates Co(II) bearing two axial chlorides, and the resulting complex is reasonably soluble in water.	Water	119-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-38
24611507-1	2014	We report the synthesis, structure, and sorption properties of a family of eight diamondoid (dia) metal-organic materials (MOMs) that are sustained by Co(II) or Zn(II) cations linked by one of three rigid ligands: 4-(2-(4-pyridyl)ethenyl)benzoate (1), 4-(pyridin-4-yl)benzoate (2), and 4-(pyridin-4-yl)acrylate (3).	Metals	98-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-157
24694877-10	2014	In addition, embelin inhibited the expression of markers of angiogenesis (COX-2, VEGF, VEGFR, and IL-8), and metastasis (MMP-2 and MMP-9) in tumor tissues.	embelin	13-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
24576559-0	2014	Importance of reduced sulfur for the equilibrium chemistry and kinetics of Fe(II), Co(II) and Ni(II) supplemented to semi-continuous stirred tank biogas reactors fed with stillage.	Sulfur	22-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-89
24520038-7	2014	For aspirin, the major mechanism is the anti-inflammatory action through the inhibition of COX-1/COX-2 and modulation of the NFkappaB or STAT3 pathway.	Aspirin	4-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
24534771-12	2014	Ellagic acid ameliorated COX-2 expression; meloxicam inhibited while indomethacin failed.	Ellagic Acid	0-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-30
24534771-14	2014	The docking study revealed a high affinity of ellagic acid towards COX-2.	Ellagic Acid	46-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-72
24534771-16	2014	The mechanisms of ellagic acid induced protection were proved to be due to reduction of NO, MDA, IL-1beta, TNF-alpha, COX-2 and NF-kappaB expression and induction of GSH and IL-10 production.	Ellagic Acid	18-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-123
24338998-7	2014	The monocyte COX-2 induction and PGE2 secretion due to thrombin were down-regulated by phloretin, deterring endothelial CD40 expression.	Phloretin	87-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
23818450-8	2014	It was found that nobiletin downregulated the expressions of Bcl-2 and COX-2 and up-regulated the expressions of Bax and caspase-3 in SMMC-7721 cells by western blotting.	nobiletin	18-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-76
23818450-9	2014	The experiment in vivo demonstrated that nobiletin significantly inhibited the growth of H22 transplantable tumor, downregulated the expressions of COX-2, up-regulated the expressions of Bax and caspase-3 detected by immunohistochemistry and western blotting, and the ratios of Bcl-2/Bax were decreased.	nobiletin	41-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	148-153
24607109-1	2014	Polyamidoamine (PAMAM) dendrimer generation 2.5 was synthesized and evaluated as sweeping agent for in-column enrichment and as stationary phase for capillary electrochromatographic separation of heavy metal ions, viz., Pb(II), Cu(II), Hg(II), Zn(II) and Co(II), in a running buffer containing 4-(2-pyridylazo)resorcinol (PAR) as a chromogenic reagent.	Poly(amidoamine)	0-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	255-261
24607109-1	2014	Polyamidoamine (PAMAM) dendrimer generation 2.5 was synthesized and evaluated as sweeping agent for in-column enrichment and as stationary phase for capillary electrochromatographic separation of heavy metal ions, viz., Pb(II), Cu(II), Hg(II), Zn(II) and Co(II), in a running buffer containing 4-(2-pyridylazo)resorcinol (PAR) as a chromogenic reagent.	Poly(amidoamine)	16-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	255-261
24607109-7	2014	Under the optimum conditions, the detection limits were 0.299, 0.184, 0.774, 0.182 and 0.047 mug/L for Pb(II), Cu(II), Hg(II), Zn(II) and Co(II), respectively.	pb(ii)	103-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	138-144
24576559-1	2014	The objective of the present study was to assess major chemical reactions and chemical forms contributing to solubility and speciation of Fe(II), Co(II), and Ni(II) during anaerobic digestion of sulfur (S)-rich stillage in semi-continuous stirred tank biogas reactors (SCSTR).	Sulfur	195-201	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	146-151
24576559-1	2014	The objective of the present study was to assess major chemical reactions and chemical forms contributing to solubility and speciation of Fe(II), Co(II), and Ni(II) during anaerobic digestion of sulfur (S)-rich stillage in semi-continuous stirred tank biogas reactors (SCSTR).	Sulfur	202-205	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	146-151
24675684-0	2014	Meloxicam executes its antitumor effects against hepatocellular carcinoma in COX-2- dependent and -independent pathways.	Meloxicam	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-82
24675684-2	2014	Meloxicam, a selective COX-2 inhibitor, has shown potential therapeutic effects against HCC, but the mechanisms accounting for its anti-cancer activities remain unclear.	Meloxicam	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-28
24675684-3	2014	METHODS AND FINDINGS: Meloxicam inhibited the ability of human HCC cells expressing higher levels of COX-2 to migrate, invade, adhere and form colonies through upregulating the expression of E-cadherin and downregulating the expression of matrix metalloproteinase (MMP) -2.	Meloxicam	22-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-106
24675684-5	2014	Addition of prostaglandin E2 (PGE2), the major product of COX-2, could abrogate the effects of meloxicam on the expression of survivin and myeloid cell leukemia-1 (Mcl-1), but not Bax and Fas-L, indicating that meloxicam induces cell apoptosis via both COX-2-dependent and -independent pathways.	Dinoprostone	12-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
24647589-7	2014	Fetal brains were collected after 6 h. In human fetal membranes, silibinin significantly decreased LPS-stimulated expression of IL-6 and IL-8, COX-2, and prostaglandins PGE2 and PGF2alpha.	Silybin	65-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	143-148
24675684-5	2014	Addition of prostaglandin E2 (PGE2), the major product of COX-2, could abrogate the effects of meloxicam on the expression of survivin and myeloid cell leukemia-1 (Mcl-1), but not Bax and Fas-L, indicating that meloxicam induces cell apoptosis via both COX-2-dependent and -independent pathways.	Dinoprostone	12-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	253-258
24675684-5	2014	Addition of prostaglandin E2 (PGE2), the major product of COX-2, could abrogate the effects of meloxicam on the expression of survivin and myeloid cell leukemia-1 (Mcl-1), but not Bax and Fas-L, indicating that meloxicam induces cell apoptosis via both COX-2-dependent and -independent pathways.	Dinoprostone	30-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
24675684-5	2014	Addition of prostaglandin E2 (PGE2), the major product of COX-2, could abrogate the effects of meloxicam on the expression of survivin and myeloid cell leukemia-1 (Mcl-1), but not Bax and Fas-L, indicating that meloxicam induces cell apoptosis via both COX-2-dependent and -independent pathways.	Dinoprostone	30-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	253-258
24675684-5	2014	Addition of prostaglandin E2 (PGE2), the major product of COX-2, could abrogate the effects of meloxicam on the expression of survivin and myeloid cell leukemia-1 (Mcl-1), but not Bax and Fas-L, indicating that meloxicam induces cell apoptosis via both COX-2-dependent and -independent pathways.	Meloxicam	95-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
24675684-5	2014	Addition of prostaglandin E2 (PGE2), the major product of COX-2, could abrogate the effects of meloxicam on the expression of survivin and myeloid cell leukemia-1 (Mcl-1), but not Bax and Fas-L, indicating that meloxicam induces cell apoptosis via both COX-2-dependent and -independent pathways.	Meloxicam	95-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	253-258
24675684-5	2014	Addition of prostaglandin E2 (PGE2), the major product of COX-2, could abrogate the effects of meloxicam on the expression of survivin and myeloid cell leukemia-1 (Mcl-1), but not Bax and Fas-L, indicating that meloxicam induces cell apoptosis via both COX-2-dependent and -independent pathways.	Meloxicam	211-220	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
24675684-8	2014	CONCLUSIONS: Meloxicam executes its antitumor effects by targeting the COX-2/MMP-2/E-cadherin, AKT, apoptotic and autophagic pathways in COX-2-dependent and -independent pathways, and inhibition of cell autophagy could help to overcome the resistance to meloxicam-induced apoptosis in HCC.	Meloxicam	13-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-76
24675684-8	2014	CONCLUSIONS: Meloxicam executes its antitumor effects by targeting the COX-2/MMP-2/E-cadherin, AKT, apoptotic and autophagic pathways in COX-2-dependent and -independent pathways, and inhibition of cell autophagy could help to overcome the resistance to meloxicam-induced apoptosis in HCC.	Meloxicam	13-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-142
24675684-8	2014	CONCLUSIONS: Meloxicam executes its antitumor effects by targeting the COX-2/MMP-2/E-cadherin, AKT, apoptotic and autophagic pathways in COX-2-dependent and -independent pathways, and inhibition of cell autophagy could help to overcome the resistance to meloxicam-induced apoptosis in HCC.	Meloxicam	254-263	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-76
24492244-1	2014	Allylic rearrangement or the migration of a double bond from its original position in the carbon skeleton to an adjacent site was observed when 3,4,5,6-tetrahydrophthalate was hydrolyzed in a basic solution and in the presence of Co(ii) and Mn(ii) under hydrothermal conditions.	Carbon	90-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	230-236
24492244-1	2014	Allylic rearrangement or the migration of a double bond from its original position in the carbon skeleton to an adjacent site was observed when 3,4,5,6-tetrahydrophthalate was hydrolyzed in a basic solution and in the presence of Co(ii) and Mn(ii) under hydrothermal conditions.	Carbon	90-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	233-235
24564195-2	2014	Chemically stable Co(II) and Cu(II) coordination complexes were prepared with this nonsoluble polyelectrolyte, poly(EGDE-DA), and studied by ss-NMR, FT-IR, thermogravimetry, and microscopy.	poly(egde-da)	111-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-24
24492244-1	2014	Allylic rearrangement or the migration of a double bond from its original position in the carbon skeleton to an adjacent site was observed when 3,4,5,6-tetrahydrophthalate was hydrolyzed in a basic solution and in the presence of Co(ii) and Mn(ii) under hydrothermal conditions.	3,4,5,6-tetrahydrophthalate	144-171	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	230-236
24492244-1	2014	Allylic rearrangement or the migration of a double bond from its original position in the carbon skeleton to an adjacent site was observed when 3,4,5,6-tetrahydrophthalate was hydrolyzed in a basic solution and in the presence of Co(ii) and Mn(ii) under hydrothermal conditions.	3,4,5,6-tetrahydrophthalate	144-171	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	233-235
24564195-5	2014	The Co(II)-poly(EGDE-DA)/H2O2 heterogeneous system produced O2, an anion superoxide (O2( ) ), and a hydroxyl radical (OH( )), which diffused into the solution at the time that a decrease in pH was detected.	Hydrogen Peroxide	25-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-11
24564195-5	2014	The Co(II)-poly(EGDE-DA)/H2O2 heterogeneous system produced O2, an anion superoxide (O2( ) ), and a hydroxyl radical (OH( )), which diffused into the solution at the time that a decrease in pH was detected.	Oxygen	27-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-11
24564195-5	2014	The Co(II)-poly(EGDE-DA)/H2O2 heterogeneous system produced O2, an anion superoxide (O2( ) ), and a hydroxyl radical (OH( )), which diffused into the solution at the time that a decrease in pH was detected.	anion superoxide	67-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-11
24564195-5	2014	The Co(II)-poly(EGDE-DA)/H2O2 heterogeneous system produced O2, an anion superoxide (O2( ) ), and a hydroxyl radical (OH( )), which diffused into the solution at the time that a decrease in pH was detected.	Oxygen	60-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-11
24564195-5	2014	The Co(II)-poly(EGDE-DA)/H2O2 heterogeneous system produced O2, an anion superoxide (O2( ) ), and a hydroxyl radical (OH( )), which diffused into the solution at the time that a decrease in pH was detected.	Hydroxyl Radical	100-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-11
24564195-7	2014	H2O2 activation by the poly(EGDE-DA) complexes with Co(II) and Cu(II) were applied on the decolorization of solutions of the azo-dye methyl orange (MO).	Hydrogen Peroxide	0-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-58
24564195-7	2014	H2O2 activation by the poly(EGDE-DA) complexes with Co(II) and Cu(II) were applied on the decolorization of solutions of the azo-dye methyl orange (MO).	poly(egde-da)	23-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-58
24564195-7	2014	H2O2 activation by the poly(EGDE-DA) complexes with Co(II) and Cu(II) were applied on the decolorization of solutions of the azo-dye methyl orange (MO).	azo-dye methyl orange	125-146	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-58
24564195-8	2014	In the presence of 63 mM H2O2, 87% of MO was removed in 10 min with Cu(II)-poly(EGDE-DA) and in 110 min with Co(II)-poly(EGDE-DA).	Hydrogen Peroxide	25-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-116
24564195-8	2014	In the presence of 63 mM H2O2, 87% of MO was removed in 10 min with Cu(II)-poly(EGDE-DA) and in 110 min with Co(II)-poly(EGDE-DA).	egde-da	121-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-116
24564195-9	2014	In addition, the pharmaceutical product epinephrine was partially oxidized to adrenochrome by the O2( )  released from the Co(II)-poly(EGDE-DA)/H2O2 heterogeneous system.	Epinephrine	40-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-130
24601533-2	2014	The metal center Co(II) ion in each complex shows a similar distorted octahedral geometry.	Metals	4-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-23
24564195-9	2014	In addition, the pharmaceutical product epinephrine was partially oxidized to adrenochrome by the O2( )  released from the Co(II)-poly(EGDE-DA)/H2O2 heterogeneous system.	Oxygen	98-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-130
24564195-9	2014	In addition, the pharmaceutical product epinephrine was partially oxidized to adrenochrome by the O2( )  released from the Co(II)-poly(EGDE-DA)/H2O2 heterogeneous system.	Hydrogen Peroxide	144-148	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-130
24503478-8	2014	The cyclooxygenase activity of nanodisc-reconstituted COX-2 was reduced by aspirin acetylation and potentiated by the nonsubstrate fatty acid palmitic acid to the same extent as detergent solubilized enzyme, independent of phospholipid composition.	Aspirin	75-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-59
24206708-2	2014	In this study, cobalt containing compounds, namely Co(II), cyanocobalamin (CN-Cbl) and hydroxylcobalamin (OH-Cbl), were well separated by reversed phase HPLC with a C8-HPLC column as the stationary phase and 8 mmol L(-1) ammonium acetate in 22%v/v methanol solution (pH 4) as the mobile phase using isocratic elution.	Cobalt	15-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-57
24503478-1	2014	Cyclooxygenases (COX-1 and COX-2) oxygenate arachidonic acid (AA) to generate prostaglandins.	Arachidonic Acid	44-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-32
24503478-1	2014	Cyclooxygenases (COX-1 and COX-2) oxygenate arachidonic acid (AA) to generate prostaglandins.	Prostaglandins	78-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-32
24503478-8	2014	The cyclooxygenase activity of nanodisc-reconstituted COX-2 was reduced by aspirin acetylation and potentiated by the nonsubstrate fatty acid palmitic acid to the same extent as detergent solubilized enzyme, independent of phospholipid composition.	Fatty Acids	131-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-59
24503478-6	2014	Nanodisc-reconstituted COX-2 exhibited similar kinetic profiles for the oxygenation of AA, eicosapentaenoic acid, and 1-arachidonoyl glycerol compared to those derived using detergent solubilized enzyme.	Eicosapentaenoic Acid	91-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-28
24503478-6	2014	Nanodisc-reconstituted COX-2 exhibited similar kinetic profiles for the oxygenation of AA, eicosapentaenoic acid, and 1-arachidonoyl glycerol compared to those derived using detergent solubilized enzyme.	1-arachidonyl monoglyceride	118-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-28
24503478-8	2014	The cyclooxygenase activity of nanodisc-reconstituted COX-2 was reduced by aspirin acetylation and potentiated by the nonsubstrate fatty acid palmitic acid to the same extent as detergent solubilized enzyme, independent of phospholipid composition.	Palmitic Acid	142-155	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-59
24503478-8	2014	The cyclooxygenase activity of nanodisc-reconstituted COX-2 was reduced by aspirin acetylation and potentiated by the nonsubstrate fatty acid palmitic acid to the same extent as detergent solubilized enzyme, independent of phospholipid composition.	Phospholipids	223-235	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-59
24659686-7	2014	GBM cells with COX-2 overexpression show increased growth of colonies in soft agar.	Agar	78-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-20
24440378-1	2014	Nimesulide, a COX-2 preferential inhibitor with a favorable gastric and cardiovascular safety profile, was responsible for some cases of acute liver failure attributed to the nitrobenzene ring.	nimesulide	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
24425867-2	2014	Isoxicam is a nonselective inhibitor of COX-1 and COX-2 whereas meloxicam displays some selectivity for COX-2.	isoxicam	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-55
24425867-2	2014	Isoxicam is a nonselective inhibitor of COX-1 and COX-2 whereas meloxicam displays some selectivity for COX-2.	Meloxicam	64-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
24425867-3	2014	Here we report crystal complexes of COX-2 with isoxicam and meloxicam at 2.0 and 2.45 angstroms, respectively, and a crystal complex of COX-1 with meloxicam at 2.4 angstroms.	isoxicam	47-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-41
24425867-3	2014	Here we report crystal complexes of COX-2 with isoxicam and meloxicam at 2.0 and 2.45 angstroms, respectively, and a crystal complex of COX-1 with meloxicam at 2.4 angstroms.	Meloxicam	60-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-41
24425867-4	2014	These structures reveal that the oxicams bind to the active site of COX-2 using a binding pose not seen with other NSAIDs through two highly coordinated water molecules.	Water	153-158	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-73
24425867-8	2014	In addition, a detailed study of meloxicam COX-2 interactions revealed that mutation of Val-434 to Ile significantly reduces inhibition by meloxicam due to subtle changes around Phe-518, giving rise to the preferential inhibition of COX-2 over COX-1.	Meloxicam	33-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
24425867-8	2014	In addition, a detailed study of meloxicam COX-2 interactions revealed that mutation of Val-434 to Ile significantly reduces inhibition by meloxicam due to subtle changes around Phe-518, giving rise to the preferential inhibition of COX-2 over COX-1.	Meloxicam	139-148	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
24425867-8	2014	In addition, a detailed study of meloxicam COX-2 interactions revealed that mutation of Val-434 to Ile significantly reduces inhibition by meloxicam due to subtle changes around Phe-518, giving rise to the preferential inhibition of COX-2 over COX-1.	Meloxicam	139-148	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	233-238
24425867-8	2014	In addition, a detailed study of meloxicam COX-2 interactions revealed that mutation of Val-434 to Ile significantly reduces inhibition by meloxicam due to subtle changes around Phe-518, giving rise to the preferential inhibition of COX-2 over COX-1.	Phenylalanine	178-181	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
24425867-8	2014	In addition, a detailed study of meloxicam COX-2 interactions revealed that mutation of Val-434 to Ile significantly reduces inhibition by meloxicam due to subtle changes around Phe-518, giving rise to the preferential inhibition of COX-2 over COX-1.	Phenylalanine	178-181	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	233-238
24634581-4	2014	We found that minocycline inhibited ConA-induced formation of autophagic acidic vacuoles, green fluorescent microtubule-associated protein 1 light chain 3 (GFP-LC3) puncta formation, gene and protein expression of autophagy biomarker BCL2/adenovirus E1B 19 kDa interacting protein 3 (BNIP3), invasion biomarker MT1-MMP, and inflammation biomarker cyclooxygenase (COX)-2.	Minocycline	14-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	347-369
24589238-0	2014	5-methoxyindole metabolites of L-tryptophan: control of COX-2 expression, inflammation and tumorigenesis.	5-methoxyindole	0-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-61
24528370-1	2014	We report single-crystal X-band EPR and magnetic measurements of the coordination polymer catena-(trans-(mu2-fumarato)tetraaquacobalt(II)), 1, and the Co(II)-doped Zn(II) analogue, 2, in different Zn:Co ratios.	Zinc	164-170	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-157
24528370-1	2014	We report single-crystal X-band EPR and magnetic measurements of the coordination polymer catena-(trans-(mu2-fumarato)tetraaquacobalt(II)), 1, and the Co(II)-doped Zn(II) analogue, 2, in different Zn:Co ratios.	Zinc	164-166	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-157
24589238-12	2014	5-hydroxytryptophan inhibits COX-2 expression through conversion to 5-MTP.	5-Hydroxytryptophan	0-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34
24589238-0	2014	5-methoxyindole metabolites of L-tryptophan: control of COX-2 expression, inflammation and tumorigenesis.	Tryptophan	31-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-61
24589238-3	2014	5-methoxyindole metabolites of L-tryptophan represent a new class of compounds that control COX-2 expression at the transcriptional level.	5-methoxyindole	0-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-97
24589238-3	2014	5-methoxyindole metabolites of L-tryptophan represent a new class of compounds that control COX-2 expression at the transcriptional level.	Tryptophan	31-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-97
24589238-10	2014	Melatonin possesses similar COX-2 suppressing and anti-cancer properties albeit at supra-pharmacological concentrations.	Melatonin	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
24590498-8	2014	As Ni(II) and Co(II) ions especially favor octahedral coordination geometry in oxygen-ligand fields, Ni(II) ions and Co(II) ions could only selectively exchange with the octahedral Zn(II) ions, as was also confirmed by the experimental results.	Nickel(2+)	3-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-123
24594722-4	2014	Each 2,5-PDC(2-) anion chelates to one Co(II) cation via the pyridine N atom and an O atom of the adjacent carboxylate group, and links to two other Co(II) cations in a bridging mode via the O atoms of the other carboxylate group.	pyridine	61-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-45
24590498-8	2014	As Ni(II) and Co(II) ions especially favor octahedral coordination geometry in oxygen-ligand fields, Ni(II) ions and Co(II) ions could only selectively exchange with the octahedral Zn(II) ions, as was also confirmed by the experimental results.	Oxygen	79-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-20
24590498-8	2014	As Ni(II) and Co(II) ions especially favor octahedral coordination geometry in oxygen-ligand fields, Ni(II) ions and Co(II) ions could only selectively exchange with the octahedral Zn(II) ions, as was also confirmed by the experimental results.	Oxygen	79-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-123
24590498-8	2014	As Ni(II) and Co(II) ions especially favor octahedral coordination geometry in oxygen-ligand fields, Ni(II) ions and Co(II) ions could only selectively exchange with the octahedral Zn(II) ions, as was also confirmed by the experimental results.	Zinc	181-187	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-20
24590498-8	2014	As Ni(II) and Co(II) ions especially favor octahedral coordination geometry in oxygen-ligand fields, Ni(II) ions and Co(II) ions could only selectively exchange with the octahedral Zn(II) ions, as was also confirmed by the experimental results.	Zinc	181-187	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-123
24424498-9	2014	It was also shown that 6-shogaol combined with gemcitabine treatment was more effective than drug alone, consistent with the downregulation of NF-kappaB activity along with its target genes COX-2, cyclinD1, survivin, cIAP-1, and XIAP.	shogaol	23-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	190-195
24424498-9	2014	It was also shown that 6-shogaol combined with gemcitabine treatment was more effective than drug alone, consistent with the downregulation of NF-kappaB activity along with its target genes COX-2, cyclinD1, survivin, cIAP-1, and XIAP.	gemcitabine	47-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	190-195
24594722-4	2014	Each 2,5-PDC(2-) anion chelates to one Co(II) cation via the pyridine N atom and an O atom of the adjacent carboxylate group, and links to two other Co(II) cations in a bridging mode via the O atoms of the other carboxylate group.	Nitrogen	70-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-45
24594722-4	2014	Each 2,5-PDC(2-) anion chelates to one Co(II) cation via the pyridine N atom and an O atom of the adjacent carboxylate group, and links to two other Co(II) cations in a bridging mode via the O atoms of the other carboxylate group.	carboxylate	107-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-45
24594722-4	2014	Each 2,5-PDC(2-) anion chelates to one Co(II) cation via the pyridine N atom and an O atom of the adjacent carboxylate group, and links to two other Co(II) cations in a bridging mode via the O atoms of the other carboxylate group.	carboxylate	212-223	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-45
23984829-0	2014	Drug analogs of COX-2 selective inhibitors lumiracoxib and valdecoxib derived from in silico search and optimization.	lumiracoxib	43-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-21
23984829-0	2014	Drug analogs of COX-2 selective inhibitors lumiracoxib and valdecoxib derived from in silico search and optimization.	valdecoxib	59-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-21
23984829-2	2014	This study presents 16 analogs of lumiracoxib and 10 analogs to valdecoxib having properties suitable as COX-2 inhibitors.	valdecoxib	64-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-110
23984829-11	2014	Path analysis indicated that number of atoms, oxygen &amp; nitrogen atoms, and Log P are the greatest determinants for formula weight for known COX-2 inhibitors.	Oxygen	46-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	144-149
23984829-11	2014	Path analysis indicated that number of atoms, oxygen &amp; nitrogen atoms, and Log P are the greatest determinants for formula weight for known COX-2 inhibitors.	Nitrogen	59-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	144-149
25337570-6	2014	Linoleic acid treatment decreased the expression levels of the cyclooxygenase (COX)-2 mRNA and protein without causing significant changes in the COX-1 levels, which was correlated with the inhibition of PGE2 synthesis.	Linoleic Acid	0-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-85
24327271-4	2014	In these cohorts, the survival benefit of aspirin was shown to depend upon the level of COX-2 expression in the primary colorectal cancer.	Aspirin	42-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-93
24327271-6	2014	Aspirin intake following colorectal cancer resection was associated with a significant improvement of survival in patients whose tumors carried mutant, but not wild-type, copies of the phosphoinositide 3-kinase (PI3KCA) gene, especially tumors that overexpressed COX-2.	Aspirin	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	263-268
24413338-8	2014	Re-expression of miR-199a-5p impaired arsenic-induced angiogenesis and tumor growth through its direct targets HIF-1alpha and COX-2.	Arsenic	38-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-131
24413338-9	2014	We further showed that arsenic induced COX-2 expression through HIF-1 regulation at the transcriptional level.	Arsenic	23-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-44
24413338-10	2014	In addition, we demonstrated that reactive oxygen species are an upstream event of miR-199a-5p/ HIF-1alpha/COX-2 pathway in arsenic-induced carcinogenesis.	Reactive Oxygen Species	34-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-112
24413338-11	2014	CONCLUSION: The findings establish critical roles of miR-199a-5p and its downstream targets HIF-1/COX-2 in arsenic-induced tumor growth and angiogenesis.	Arsenic	107-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-103
24413338-14	2014	Chronic arsenic exposure and angiogenesis in human bronchial epithelial cells via the ROS/miR-199a-5p/HIF-1alpha/COX-2 Pathway.	Arsenic	8-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-118
24521161-4	2014	Astaxanthin (5 mum) caused a significant decrease in the protein content and the mRNA levels of inducible nitric oxide (iNOS) and cyclooxygenase (COX)-2, and decreased the release of prostaglandin E2 from HaCaT keratinocytes after UVB (20 mJ/cm(2) ) or UVC (5 mJ/cm(2) ) irradiation.	astaxanthine	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	130-152
24483845-3	2014	AREAS COVERED: The authors illustrate the role of prostaglandins following the overexpression of PTGS2 (COX-2) in signaling pathways.	Prostaglandins	50-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
25337570-8	2014	CONCLUSIONS: Taken together, our results indicate that linoleic acid inhibits the production of PGE2 and activity of telomerase by suppressing COX-2 and hTERT expression.	Linoleic Acid	55-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	143-148
25337570-8	2014	CONCLUSIONS: Taken together, our results indicate that linoleic acid inhibits the production of PGE2 and activity of telomerase by suppressing COX-2 and hTERT expression.	Dinoprostone	96-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	143-148
24141321-2	2014	In the present study, we evaluated the neuronal activity in the brain to elucidate the possible mechanisms underlying a stress-specific relevance between COX-2-related signaling and activation of the HPA axis under infectious (lipopolysaccharide, LPS), hypoglycemic (2-deoxy-D-glucose, 2DG) and restraint (1 hr) stress conditions.	Deoxyglucose	286-289	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	154-159
24013551-6	2014	The expression level of COX-2 and GFAP proteins was up regulated by LPS but the increased level of COX-2 and GFAP was significantly down regulated by treatment with guggulipid.	guggulu extract	165-175	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
24141321-2	2014	In the present study, we evaluated the neuronal activity in the brain to elucidate the possible mechanisms underlying a stress-specific relevance between COX-2-related signaling and activation of the HPA axis under infectious (lipopolysaccharide, LPS), hypoglycemic (2-deoxy-D-glucose, 2DG) and restraint (1 hr) stress conditions.	Deoxyglucose	267-284	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	154-159
24013551-6	2014	The expression level of COX-2 and GFAP proteins was up regulated by LPS but the increased level of COX-2 and GFAP was significantly down regulated by treatment with guggulipid.	guggulu extract	165-175	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-104
24658473-13	2014	CONCLUSION: In the present proof-of-concept trial, short-term treatment with the selective COX-2-inhibitor parecoxib influenced neither PPT nor edema or pain.	parecoxib	107-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-96
24518515-2	2014	Celecoxib is a selective COX-2 inhibitor and reported to prevent the progression of prostate cancer.	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-30
24518515-9	2014	CONCLUSIONS: Celecoxib exerts antitumor activity through EP2 signaling regulating AR and COX-2 expression.	Celecoxib	13-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-94
24366870-5	2014	LMW HA was a potent stimulant of AA release in a time- and dose-dependent manner, induced cPLA2alpha, ERK1/2, p38, and JNK phosphorylation, as well as activated COX2 expression and prostaglandin (PG) E2 production in primary human monocytes, murine RAW 264.7, and wild-type bone marrow-derived macrophages.	2-(4-Amino-N-ethylanilino)ethanol	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	161-165
24300990-2	2014	The addition of either perylene or axial ligands to Co(II)(bisporphyrin) completely transforms the syn form into the anti because of strong pi-pi interaction and axial coordination, respectively.	Perylene	23-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-58
24402189-1	2014	Efficient photocatalytic hydrogen evolution is obtained from 1 M phosphate buffer at pH 7 in the presence of a Ru(bpy)3(2+) sensitizer, an ascorbic acid sacrificial donor, and a water-soluble Co(II) porphyrin catalyst.	Hydrogen	25-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	192-198
24402189-1	2014	Efficient photocatalytic hydrogen evolution is obtained from 1 M phosphate buffer at pH 7 in the presence of a Ru(bpy)3(2+) sensitizer, an ascorbic acid sacrificial donor, and a water-soluble Co(II) porphyrin catalyst.	Phosphates	65-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	192-198
24402189-1	2014	Efficient photocatalytic hydrogen evolution is obtained from 1 M phosphate buffer at pH 7 in the presence of a Ru(bpy)3(2+) sensitizer, an ascorbic acid sacrificial donor, and a water-soluble Co(II) porphyrin catalyst.	ru(bpy)3	111-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	192-198
24402189-1	2014	Efficient photocatalytic hydrogen evolution is obtained from 1 M phosphate buffer at pH 7 in the presence of a Ru(bpy)3(2+) sensitizer, an ascorbic acid sacrificial donor, and a water-soluble Co(II) porphyrin catalyst.	Water	178-183	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	192-198
24300990-2	2014	The addition of either perylene or axial ligands to Co(II)(bisporphyrin) completely transforms the syn form into the anti because of strong pi-pi interaction and axial coordination, respectively.	bisporphyrin	59-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-58
24300990-9	2014	The addition of axial ligands to Co(II)(bisporphyrin) also completely transforms the syn form into the anti form.	bisporphyrin)	40-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-39
24300990-10	2014	While additions of THF and I2/I(-) both result in the formation of five-coordinate complexes, Co(II) is oxidized to Co(III) in the case of the latter.	co(iii)	116-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-100
24300990-11	2014	However, additions of 1-methylimidazole, pyridine and pyrazine as axial ligands result in the formation of a six-coordinate complex in which Co(II) is spontaneously oxidized to Co(III) in air.	1-methylimidazole	22-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	141-147
24300990-11	2014	However, additions of 1-methylimidazole, pyridine and pyrazine as axial ligands result in the formation of a six-coordinate complex in which Co(II) is spontaneously oxidized to Co(III) in air.	pyridine	41-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	141-147
24300990-11	2014	However, additions of 1-methylimidazole, pyridine and pyrazine as axial ligands result in the formation of a six-coordinate complex in which Co(II) is spontaneously oxidized to Co(III) in air.	Pyrazines	54-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	141-147
24433170-2	2014	The synthesis of a COX-2 inhibitor and the wide-ranging derivatization of the 2-pyrone moiety to trifluoromethyl substituted aromatics and heteroaromatics is also disclosed.	2-pyrone	78-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-24
24300990-11	2014	However, additions of 1-methylimidazole, pyridine and pyrazine as axial ligands result in the formation of a six-coordinate complex in which Co(II) is spontaneously oxidized to Co(III) in air.	co(iii)	177-184	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	141-147
24437997-0	2014	High nuclearity (octa-, dodeca-, and pentadecanuclear) metal (M = Co(II), Ni(II)) phosphonate cages: synthesis, structure, and magnetic behavior.	Metals	55-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-72
24433170-2	2014	The synthesis of a COX-2 inhibitor and the wide-ranging derivatization of the 2-pyrone moiety to trifluoromethyl substituted aromatics and heteroaromatics is also disclosed.	trifluoromethyl substituted aromatics	97-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-24
24125042-1	2014	A multidentate ligand platform is introduced that enables the isolation of both homo- and heterobimetallic complexes of divalent first-row transition metal ions such as Mn(II), Fe(II), and Co(II).	Metals	98-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	189-195
24605250-7	2014	Daily low-dose aspirin achieves complete and persistent inhibition of cyclooxygenase (COX)-1 in platelets (in pre-systemic circulation) while causing a limited and rapidly reversible inhibitory effect on COX-2 and/or COX-1 expressed in nucleated cells.	Aspirin	15-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	204-209
24140606-7	2014	Moreover, UDMA stimulated COX-2, HO-1 and CES2 mRNA expression of pulp cells.	urethane dimethacrylate luting resin	10-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-31
24370195-6	2014	RESULTS: Both CS- and LPS-applications upregulated COX-2 and RANKL but downregulated OPG.	Cesium	14-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-56
24441123-1	2014	Four new variants of the 1,4-benzenedicarboxylate MIL-53 structure have been prepared for Co(II) under solvothermal conditions and their structures solved and refined from single-crystal X-ray data.	1,4-benzenedicarboxylate	25-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-96
24441123-1	2014	Four new variants of the 1,4-benzenedicarboxylate MIL-53 structure have been prepared for Co(II) under solvothermal conditions and their structures solved and refined from single-crystal X-ray data.	mil-53	50-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-96
24441123-2	2014	All materials contain pendant pyridine-N-oxide ligands that bridge pairs of Co(II) atoms in the inorganic backbone of the structure via O.	pyridine N-oxide	30-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-82
24243443-0	2014	Synthesis and evaluation of 2-(2-arylmorpholino)ethyl esters of ibuprofen hydrochlorides as COX-2 and serotonin reuptake inhibitors.	2-(2-arylmorpholino)ethyl esters	28-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-97
24243443-0	2014	Synthesis and evaluation of 2-(2-arylmorpholino)ethyl esters of ibuprofen hydrochlorides as COX-2 and serotonin reuptake inhibitors.	ibuprofen hydrochlorides	64-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-97
24243443-1	2014	Based on the positive effects of COX-2 inhibitors on depressive symptoms and the desirable physicochemical and biological properties of the morpholine group, a series of novel 2-(2-arylmorpholino)ethyl esters of ibuprofen hydrochlorides were designed, synthesized, and tested for their COX-2 inhibitory and serotonin reuptake inhibitory activities in vitro.	2-(2-arylmorpholino)ethyl esters	176-208	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-38
24243443-1	2014	Based on the positive effects of COX-2 inhibitors on depressive symptoms and the desirable physicochemical and biological properties of the morpholine group, a series of novel 2-(2-arylmorpholino)ethyl esters of ibuprofen hydrochlorides were designed, synthesized, and tested for their COX-2 inhibitory and serotonin reuptake inhibitory activities in vitro.	2-(2-arylmorpholino)ethyl esters	176-208	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	286-291
24370195-8	2014	NS398 (a specific inhibitor of COX-2) significantly inhibited CS-induced RANKL-upregulation but not LPS-induced RANKL upregulation, indicating a critical role of COX-2/PGE2 pathway in CS-induced osteoclastogenesis.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	0-5	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-36
24243443-1	2014	Based on the positive effects of COX-2 inhibitors on depressive symptoms and the desirable physicochemical and biological properties of the morpholine group, a series of novel 2-(2-arylmorpholino)ethyl esters of ibuprofen hydrochlorides were designed, synthesized, and tested for their COX-2 inhibitory and serotonin reuptake inhibitory activities in vitro.	ibuprofen hydrochlorides	212-236	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-38
24243443-2	2014	The structure-activity relationships of the 2-(2-arylmorpholino)ethyl esters of ibuprofen hydrochlorides as dual COX-2 and serotonin reuptake inhibitors were determined and discussed in detail.	2-(2-arylmorpholino)ethyl esters	44-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-118
24370195-8	2014	NS398 (a specific inhibitor of COX-2) significantly inhibited CS-induced RANKL-upregulation but not LPS-induced RANKL upregulation, indicating a critical role of COX-2/PGE2 pathway in CS-induced osteoclastogenesis.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	0-5	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	162-167
24243443-2	2014	The structure-activity relationships of the 2-(2-arylmorpholino)ethyl esters of ibuprofen hydrochlorides as dual COX-2 and serotonin reuptake inhibitors were determined and discussed in detail.	ibuprofen hydrochlorides	80-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-118
24370195-8	2014	NS398 (a specific inhibitor of COX-2) significantly inhibited CS-induced RANKL-upregulation but not LPS-induced RANKL upregulation, indicating a critical role of COX-2/PGE2 pathway in CS-induced osteoclastogenesis.	Cesium	62-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-36
24243443-4	2014	The compound 2-[2-(4-benzyloxyphenyl)morpholino]ethyl 2-(4-iso-butylphenyl)-propanoate hydrochloride (1k) shows better COX-2 inhibitory activity (IC50  = 0.78 microM) than ibuprofen (IC50  = 7.6 microM), and it simultaneously possesses favorable serotonin reuptake inhibitory activity.	2-[2-(4-benzyloxyphenyl)morpholino]ethyl 2-(4-iso-butylphenyl)-propanoate hydrochloride	13-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-124
24243443-4	2014	The compound 2-[2-(4-benzyloxyphenyl)morpholino]ethyl 2-(4-iso-butylphenyl)-propanoate hydrochloride (1k) shows better COX-2 inhibitory activity (IC50  = 0.78 microM) than ibuprofen (IC50  = 7.6 microM), and it simultaneously possesses favorable serotonin reuptake inhibitory activity.	Ibuprofen	172-181	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-124
24243443-4	2014	The compound 2-[2-(4-benzyloxyphenyl)morpholino]ethyl 2-(4-iso-butylphenyl)-propanoate hydrochloride (1k) shows better COX-2 inhibitory activity (IC50  = 0.78 microM) than ibuprofen (IC50  = 7.6 microM), and it simultaneously possesses favorable serotonin reuptake inhibitory activity.	Serotonin	246-255	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-124
24370195-8	2014	NS398 (a specific inhibitor of COX-2) significantly inhibited CS-induced RANKL-upregulation but not LPS-induced RANKL upregulation, indicating a critical role of COX-2/PGE2 pathway in CS-induced osteoclastogenesis.	Dinoprostone	168-172	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-36
24370195-8	2014	NS398 (a specific inhibitor of COX-2) significantly inhibited CS-induced RANKL-upregulation but not LPS-induced RANKL upregulation, indicating a critical role of COX-2/PGE2 pathway in CS-induced osteoclastogenesis.	Cesium	184-186	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-36
24384558-1	2014	5-Methoxytryptophan (5-MTP), a catabolic product of tryptophan, can block Cox-2 overexpression in cancer cells as well as suppress cancer cell growth, migration and invasion.	5-methoxytryptophan	0-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
24384558-1	2014	5-Methoxytryptophan (5-MTP), a catabolic product of tryptophan, can block Cox-2 overexpression in cancer cells as well as suppress cancer cell growth, migration and invasion.	Tryptophan	9-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
24327721-1	2014	Naproxen [(S)-6-methoxy-alpha-methyl-2-naphthaleneacetic acid] is a potent nonsteroidal anti-inflammatory drug that inhibits both COX-1 and COX-2 and is widely used as an over-the-counter medication.	Naproxen	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-145
24172143-1	2014	BACKGROUND AND PURPOSE: The COX-2/PGE2 pathway in hypoxic cancer cells has important implications for stimulation of inflammation and tumourigenesis.	Dinoprostone	34-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
24172143-6	2014	KEY RESULTS: The hypoxia-induced increase in COX-2 protein and mRNA levels and promoter activity were suppressed by dexamethasone, and this effect of dexamethasone was antagonized by the GR antagonist RU486.	Dexamethasone	116-129	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-50
24172143-6	2014	KEY RESULTS: The hypoxia-induced increase in COX-2 protein and mRNA levels and promoter activity were suppressed by dexamethasone, and this effect of dexamethasone was antagonized by the GR antagonist RU486.	Dexamethasone	150-163	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-50
24172143-6	2014	KEY RESULTS: The hypoxia-induced increase in COX-2 protein and mRNA levels and promoter activity were suppressed by dexamethasone, and this effect of dexamethasone was antagonized by the GR antagonist RU486.	Mifepristone	201-206	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-50
24172143-7	2014	Overexpression of GILZ in A549 cells also inhibited hypoxia-induced COX-2 expression levels and knockdown of GILZ reduced the glucocorticoid-mediated inhibition of hypoxia-induced COX-2 expression, indicating that the inhibitory effects of dexamethasone on hypoxia-induced COX-2 are mediated by GILZ.	Dexamethasone	240-253	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	180-185
24172143-7	2014	Overexpression of GILZ in A549 cells also inhibited hypoxia-induced COX-2 expression levels and knockdown of GILZ reduced the glucocorticoid-mediated inhibition of hypoxia-induced COX-2 expression, indicating that the inhibitory effects of dexamethasone on hypoxia-induced COX-2 are mediated by GILZ.	Dexamethasone	240-253	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	180-185
24172143-10	2014	CONCLUSION AND IMPLICATIONS: Dexamethasone-induced upregulation of GILZ not only inhibits the hypoxic-evoked induction of COX-2 expression and cell invasion but further blocks the HIF-1 pathway by destabilizing HIF-1alpha expression.	Dexamethasone	29-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-127
24327721-1	2014	Naproxen [(S)-6-methoxy-alpha-methyl-2-naphthaleneacetic acid] is a potent nonsteroidal anti-inflammatory drug that inhibits both COX-1 and COX-2 and is widely used as an over-the-counter medication.	Naproxen	10-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-145
24285354-8	2014	Consistent with its ability to induce apoptosis, the acacetin-mediated inhibition of the pro-survival pathway, Akt, and of the NF-kappaB pathway was accompanied by a marked reduction in the levels of the NF-kappaB-regulated anti-apoptotic proteins, Bcl-2 and X-linked inhibitor of apoptosis protein (XIAP), as well as of the proliferative protein, cyclooxygenase (COX)-2.	acacetin	53-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	348-370
31986579-1	2014	By using a rigid multicarboxylate ligand, 4,5-di(4"-carboxylphenyl)phthalic acid (H4 L), two CoII complexes formulated as [Co4 L2 (4,4"-bpy)(H2 O)6 ] 3.5 H2 O (4,4"-bpy=4,4"-bipyridine) (1) and [Co2 L(azene)(H2 O)3 ] DMF (azene=(E)-1,2-di(pyridin-4-yl)diazene, DMF=dimethylformamide) (2) have been synthesized and structurally characterized by single-crystal X-ray diffraction.	Phthalic Acids	42-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-97
31986579-1	2014	By using a rigid multicarboxylate ligand, 4,5-di(4"-carboxylphenyl)phthalic acid (H4 L), two CoII complexes formulated as [Co4 L2 (4,4"-bpy)(H2 O)6 ] 3.5 H2 O (4,4"-bpy=4,4"-bipyridine) (1) and [Co2 L(azene)(H2 O)3 ] DMF (azene=(E)-1,2-di(pyridin-4-yl)diazene, DMF=dimethylformamide) (2) have been synthesized and structurally characterized by single-crystal X-ray diffraction.	tris(2,2'-bipyridyl)cobalt(II)	123-147	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-97
31986579-1	2014	By using a rigid multicarboxylate ligand, 4,5-di(4"-carboxylphenyl)phthalic acid (H4 L), two CoII complexes formulated as [Co4 L2 (4,4"-bpy)(H2 O)6 ] 3.5 H2 O (4,4"-bpy=4,4"-bipyridine) (1) and [Co2 L(azene)(H2 O)3 ] DMF (azene=(E)-1,2-di(pyridin-4-yl)diazene, DMF=dimethylformamide) (2) have been synthesized and structurally characterized by single-crystal X-ray diffraction.	Water	141-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-97
31986579-1	2014	By using a rigid multicarboxylate ligand, 4,5-di(4"-carboxylphenyl)phthalic acid (H4 L), two CoII complexes formulated as [Co4 L2 (4,4"-bpy)(H2 O)6 ] 3.5 H2 O (4,4"-bpy=4,4"-bipyridine) (1) and [Co2 L(azene)(H2 O)3 ] DMF (azene=(E)-1,2-di(pyridin-4-yl)diazene, DMF=dimethylformamide) (2) have been synthesized and structurally characterized by single-crystal X-ray diffraction.	4,4'-bipyridyl	160-184	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-97
31986579-1	2014	By using a rigid multicarboxylate ligand, 4,5-di(4"-carboxylphenyl)phthalic acid (H4 L), two CoII complexes formulated as [Co4 L2 (4,4"-bpy)(H2 O)6 ] 3.5 H2 O (4,4"-bpy=4,4"-bipyridine) (1) and [Co2 L(azene)(H2 O)3 ] DMF (azene=(E)-1,2-di(pyridin-4-yl)diazene, DMF=dimethylformamide) (2) have been synthesized and structurally characterized by single-crystal X-ray diffraction.	Water	195-214	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-97
31986579-1	2014	By using a rigid multicarboxylate ligand, 4,5-di(4"-carboxylphenyl)phthalic acid (H4 L), two CoII complexes formulated as [Co4 L2 (4,4"-bpy)(H2 O)6 ] 3.5 H2 O (4,4"-bpy=4,4"-bipyridine) (1) and [Co2 L(azene)(H2 O)3 ] DMF (azene=(E)-1,2-di(pyridin-4-yl)diazene, DMF=dimethylformamide) (2) have been synthesized and structurally characterized by single-crystal X-ray diffraction.	3'-dimethylaminoflavone	217-220	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-97
31986579-1	2014	By using a rigid multicarboxylate ligand, 4,5-di(4"-carboxylphenyl)phthalic acid (H4 L), two CoII complexes formulated as [Co4 L2 (4,4"-bpy)(H2 O)6 ] 3.5 H2 O (4,4"-bpy=4,4"-bipyridine) (1) and [Co2 L(azene)(H2 O)3 ] DMF (azene=(E)-1,2-di(pyridin-4-yl)diazene, DMF=dimethylformamide) (2) have been synthesized and structurally characterized by single-crystal X-ray diffraction.	diazene	222-259	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-97
31986579-1	2014	By using a rigid multicarboxylate ligand, 4,5-di(4"-carboxylphenyl)phthalic acid (H4 L), two CoII complexes formulated as [Co4 L2 (4,4"-bpy)(H2 O)6 ] 3.5 H2 O (4,4"-bpy=4,4"-bipyridine) (1) and [Co2 L(azene)(H2 O)3 ] DMF (azene=(E)-1,2-di(pyridin-4-yl)diazene, DMF=dimethylformamide) (2) have been synthesized and structurally characterized by single-crystal X-ray diffraction.	3'-dimethylaminoflavone	261-282	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-97
24337227-0	2014	H2S inhibition of chemical hypoxia-induced proliferation of HPASMCs is mediated by the upregulation of COX-2/PGI2.	Hydrogen Sulfide	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-108
24337484-2	2014	Cyclooxygenase (COX) converts arachidonic acid to prostanoids, and increased expression of its isoform, COX-2, has been observed in lung cancer tissue.	Arachidonic Acid	30-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
24337227-0	2014	H2S inhibition of chemical hypoxia-induced proliferation of HPASMCs is mediated by the upregulation of COX-2/PGI2.	Epoprostenol	109-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-108
24337227-6	2014	The exposure of the HPASMCs to CoCl(2) markedly increased cell proliferation, accompanied by a decrease in COX-2 expression, PGI(2) secretion and H(2)S levels; however, the levels of ROS were not altered.	cobaltous chloride	31-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-112
24337227-10	2014	Importantly, the exposure of the cells to H(2)S suppressed the CoCl(2)-induced downregulation in COX-2 expression and PGI(2) secretion from the HPASMCs.	Hydrogen Sulfide	42-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
24337227-10	2014	Importantly, the exposure of the cells to H(2)S suppressed the CoCl(2)-induced downregulation in COX-2 expression and PGI(2) secretion from the HPASMCs.	cobaltous chloride	63-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
24337227-11	2014	In conclusion, the results from the current study suggest that H(2)S enhances hypoxia-induced cell proliferation through the upregulation of COX-2/PGI(2), as opposed to ROS.	Hydrogen Sulfide	63-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	141-146
24337227-11	2014	In conclusion, the results from the current study suggest that H(2)S enhances hypoxia-induced cell proliferation through the upregulation of COX-2/PGI(2), as opposed to ROS.	Prostaglandins I	147-150	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	141-146
24337484-3	2014	The aim of the present study was to investigate expression alteration of COX-2 in A549 lung cancer cells following butein treatment at the mRNA and protein levels by quantitative polymerase chain reaction and western blotting, respectively.	butein	115-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-78
24337484-4	2014	It was observed that COX-2 mRNA and protein levels were significantly downregulated in the butein treatment group in comparison with the control group (P&lt;0.05).	butein	91-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-26
24640603-1	2014	Celecoxib is a selective inhibitor of COX-2, whose connection with the development and progression of human tumors has been extensively studied.	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-43
24374095-5	2014	We found that pretreatment of trophoblasts with 1,25(OH)2D3 significantly reduced 8-isoprostane and the ratio of thromboxane-A2 to prostacyclin production, and blocked COX-2 expression induced by CoCl2.	Calcitriol	48-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	168-173
24374095-5	2014	We found that pretreatment of trophoblasts with 1,25(OH)2D3 significantly reduced 8-isoprostane and the ratio of thromboxane-A2 to prostacyclin production, and blocked COX-2 expression induced by CoCl2.	cobaltous chloride	196-201	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	168-173
24355293-19	2014	SIGNIFICANCE: These results indicate that 1.5-DHP produces anti-inflammatory, antinociceptive and antipyretic effects by PGE2 synthesis reduction through COX-1/COX-2 inhibition and by TNF-alpha synthesis/release inhibition.	Dinoprostone	121-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	160-165
24361493-0	2014	Preparation, characterization of electrospun meso-hydroxylapatite nanofibers and their sorptions on Co(II).	meso-hydroxylapatite	45-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-106
24361493-1	2014	In this work, mesoporous hydroxylapatite (meso-HA) nanofibers were prepared via calcination process with polyvinyl alcohol/HA (PVA/HA) hybrid nanofibers fabricated by electrospinning technique as precursors, and the removal efficiency of meso-HA nanofibers toward Co(II) was evaluated via sorption kinetics and sorption isotherms.	mesoporous hydroxylapatite	14-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	264-270
24161591-2	2014	In this study, we have used human myometrial cells to investigate whether cAMP potentiates the ability of progesterone to repress IL-1beta-driven COX-2 expression.	Cyclic AMP	74-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	146-151
24161591-2	2014	In this study, we have used human myometrial cells to investigate whether cAMP potentiates the ability of progesterone to repress IL-1beta-driven COX-2 expression.	Progesterone	106-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	146-151
24161591-3	2014	We found that forskolin enhanced progesterone-repression of IL-1beta-driven COX-2 expression in association with delayed IL-1beta-induced nuclear phospho-p65 entry and reduced NF-kappaB binding to the COX-2 promoter.	Colforsin	14-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-81
24161591-3	2014	We found that forskolin enhanced progesterone-repression of IL-1beta-driven COX-2 expression in association with delayed IL-1beta-induced nuclear phospho-p65 entry and reduced NF-kappaB binding to the COX-2 promoter.	Colforsin	14-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	201-206
24060479-1	2014	New Co(II) complexes with drugs such as trimethoprim (TMP), cimetidine (CTD), niacinamide (NAM) and ofloxacin (OFL) as ligands were synthesized.	Trimethoprim	40-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
24060479-1	2014	New Co(II) complexes with drugs such as trimethoprim (TMP), cimetidine (CTD), niacinamide (NAM) and ofloxacin (OFL) as ligands were synthesized.	Trimethoprim	54-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
24060479-1	2014	New Co(II) complexes with drugs such as trimethoprim (TMP), cimetidine (CTD), niacinamide (NAM) and ofloxacin (OFL) as ligands were synthesized.	Cimetidine	60-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
24060479-1	2014	New Co(II) complexes with drugs such as trimethoprim (TMP), cimetidine (CTD), niacinamide (NAM) and ofloxacin (OFL) as ligands were synthesized.	Cimetidine	72-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
24060479-1	2014	New Co(II) complexes with drugs such as trimethoprim (TMP), cimetidine (CTD), niacinamide (NAM) and ofloxacin (OFL) as ligands were synthesized.	Niacinamide	78-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
24060479-1	2014	New Co(II) complexes with drugs such as trimethoprim (TMP), cimetidine (CTD), niacinamide (NAM) and ofloxacin (OFL) as ligands were synthesized.	Ofloxacin	100-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
24900856-1	2014	Fluorocoxib A is an effective COX-2-targeted optical imaging agent, used for in vivo detection of inflammatory tissues and premalignant and malignant tumors that express elevated levels of COX-2 (Uddin et al.	fluorocoxib A	0-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-35
24900856-1	2014	Fluorocoxib A is an effective COX-2-targeted optical imaging agent, used for in vivo detection of inflammatory tissues and premalignant and malignant tumors that express elevated levels of COX-2 (Uddin et al.	fluorocoxib A	0-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	189-194
24900856-4	2014	In an effort to discover novel optical probes for COX-2, a trifluoromethyl analogue of fluorocoxib A (CF3-fluorocoxib A) was synthesized and evaluated for its ability to inhibit COX-2 in vitro purified enzyme and human cancer cell lines.	fluorocoxib A	87-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-55
24900856-4	2014	In an effort to discover novel optical probes for COX-2, a trifluoromethyl analogue of fluorocoxib A (CF3-fluorocoxib A) was synthesized and evaluated for its ability to inhibit COX-2 in vitro purified enzyme and human cancer cell lines.	fluorocoxib A	87-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	178-183
24400781-3	2014	The Co(II)-catalyzed process can tolerate various substitution patterns and produces the corresponding 2H-chromene products in good isolated yields.	5,7-dimethoxy-2-methyl-2H-benzopyran	103-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
24465925-7	2014	For COX-2 and IL-6 this increase of mRNA is due to an mRNA stabilizing effect of TE and betulin, a process in which p38 MAPK and HuR are involved.	betulin	88-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
24400974-1	2014	A series of new hybrid multilayers has been synthesized by insertion-grafting of transition metal (Cu(II), Co(II), Ni(II), and Zn(II)) tetrasulfonato phthalocyanines between layers of Cu(II) and Co(II) simple hydroxides.	zn(ii)) tetrasulfonato phthalocyanines	127-165	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	195-201
24438088-1	2014	BACKGROUND: Recent studies have shown that glucosamine inhibits the proliferation of various human cancer cell lines and downregulates the activity of COX-2, HIF-1alpha, p70S6K, and transglutaminase 2.	Glucosamine	43-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-156
24438088-2	2014	Because the IGF-1R/Akt pathway is a common upstream regulator of p70S6K, HIF-1alpha, and COX-2, we hypothesized that glucosamine inhibits cancer cell proliferation through this pathway.	Glucosamine	117-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-94
24578654-4	2014	In the title complex, the Co(II) ion is six-coordinated by two pyridine N atoms and two carboxyl O atoms from two 2-picolinic acid anions, and two O atoms from two H2O molecules, and forming a slightly distorted octahedral geometry.	pyridine n	63-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-32
24578654-4	2014	In the title complex, the Co(II) ion is six-coordinated by two pyridine N atoms and two carboxyl O atoms from two 2-picolinic acid anions, and two O atoms from two H2O molecules, and forming a slightly distorted octahedral geometry.	picolinic acid	114-130	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-32
24578654-4	2014	In the title complex, the Co(II) ion is six-coordinated by two pyridine N atoms and two carboxyl O atoms from two 2-picolinic acid anions, and two O atoms from two H2O molecules, and forming a slightly distorted octahedral geometry.	Water	164-167	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-32
24361187-2	2014	All of compounds showed strong inhibition of COX-2 with IC50 values in the range of 0.1-0.2muM and in most cases had stronger anti-inflammatory and analgesic effects than indomethacin at doses 3 and 6mg/kg.	Indomethacin	171-183	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-50
24361187-3	2014	Among them, 5-(4-chlorophenyl)-6-(4-(methylsulfonyl) phenyl)-3-(methylthio)-1,2,4-triazine (9c) was the most potent and selective COX-2 compound; its selectivity index of 395 was comparable to celecoxib (SI=405).	5-(4-chlorophenyl)-6-(4-(methylsulfonyl) phenyl)-3-(methylthio)-1,2,4-triazine	12-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	130-135
24333447-1	2014	The cyclooxygenase (COX) enzyme isoforms COX-1 and COX-2 catalyze the main step in the generation of prostanoids that mediate major physiological functions.	Prostaglandins	101-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-56
24333447-4	2014	Here we show that the sensitivity of both COX-1 and COX-2 to EP1 is altered upon modification of one lysine residue.	Lysine	101-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-57
24333447-5	2014	A point mutation of lysine to-arginine in position 432 of COX-2 (K432R) yields an enzyme with decreased sensitivity to EP1 -mediated degradation.	Lysine	20-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
24333447-5	2014	A point mutation of lysine to-arginine in position 432 of COX-2 (K432R) yields an enzyme with decreased sensitivity to EP1 -mediated degradation.	Arginine	30-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
24416340-7	2014	In addition, Wnt5a treatment stimulated macrophages to produce inflammatory cytokines and COX-2/PGE2, which was also suppressed by SFRP5 from GECs.	Dinoprostone	96-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-95
24695963-2	2014	Individual members of this large family of repressors coordinate Cu(I) or Ni(II)/Co(II) or perform cysteine sulfur chemistry in mitigating the effects of metal or metabolite toxicity, respectively.	cuprous ion	65-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-87
24695963-2	2014	Individual members of this large family of repressors coordinate Cu(I) or Ni(II)/Co(II) or perform cysteine sulfur chemistry in mitigating the effects of metal or metabolite toxicity, respectively.	Nickel(2+)	74-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-87
24695963-2	2014	Individual members of this large family of repressors coordinate Cu(I) or Ni(II)/Co(II) or perform cysteine sulfur chemistry in mitigating the effects of metal or metabolite toxicity, respectively.	Metals	154-159	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-87
24386899-1	2014	BACKGROUND: Parecoxib sodium is the first parenteral COX-2 inhibitor used for pain management licensed for postoperative pain.	parecoxib	12-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-58
25422199-1	2014	Cyclo-oxygenase-2(Cox-2), a key regulator of inflammation-producing prostaglandins, promotes cell proliferation and growth.	Prostaglandins	68-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-23
24815456-0	2014	Anticancer effect of COX-2 inhibitor DuP-697 alone and in combination with tyrosine kinase inhibitor (E7080) on colon cancer cell lines.	DuP 697	37-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-26
24815456-2	2014	In this study, we aimed to investigate effects of DuP-697, an irreversible selective inhibitor of COX- 2 on colorectal cancer cells alone and in combination with a promising new multi-targeted kinase inhibitor E7080.	DuP 697	50-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-104
24161694-0	2014	Quercetin modulates OTA-induced oxidative stress and redox signalling in HepG2 cells - up regulation of Nrf2 expression and down regulation of NF-kappaB and COX-2.	Quercetin	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	157-162
24161694-13	2014	Quercetin"s anti-inflammatory property was exhibited as it down regulated COX-2.	Quercetin	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
24592203-1	2014	A new Schiff base and a new series of Co(II), Ni(II), Cu(II), Cd(II), and Hg(II) complexes were synthesized by the condensation of naphthofuran-2-carbohydrazide and diacetylmonoxime.	cd(ii)	62-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-44
24592203-1	2014	A new Schiff base and a new series of Co(II), Ni(II), Cu(II), Cd(II), and Hg(II) complexes were synthesized by the condensation of naphthofuran-2-carbohydrazide and diacetylmonoxime.	naphtho[2,1-b]furan-2-carbohydrazide	131-160	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-44
24592203-1	2014	A new Schiff base and a new series of Co(II), Ni(II), Cu(II), Cd(II), and Hg(II) complexes were synthesized by the condensation of naphthofuran-2-carbohydrazide and diacetylmonoxime.	diacetylmonoxime	165-181	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-44
24592203-2	2014	Metal complexes of the Schiff base were prepared from their chloride salts of Co(II), Ni(II), Cu(II), Cd(II), and Hg(II) in ethanol.	Metals	0-5	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-84
24592203-2	2014	Metal complexes of the Schiff base were prepared from their chloride salts of Co(II), Ni(II), Cu(II), Cd(II), and Hg(II) in ethanol.	Schiff Bases	23-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-84
24592203-5	2014	The elemental analysis of the complexes confirm the stoichiometry of the type CuL2Cl2 and MLCl2 where M = Ni(II), Co(II), Cd(II), and Hg(II) and L = Schiff base.	cul2cl2	78-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-120
24592203-5	2014	The elemental analysis of the complexes confirm the stoichiometry of the type CuL2Cl2 and MLCl2 where M = Ni(II), Co(II), Cd(II), and Hg(II) and L = Schiff base.	mlcl2	90-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-120
24592203-7	2014	In the light of these results, Co(II), Ni(II), and Cu(II) complexes are assigned octahedral geometry, Cd(II), and Hg(II) complexes tetrahedral geometry.	cd(ii)	102-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-37
25371658-2	2014	By these spectral studies it is found that Co(II), Ni(II), and Cu(II) complexes have exhibited octahedral geometry whereas the Zn(II), Cd(II), and Hg(II) complexes have exhibited tetrahedral geometry.	zn(ii)	127-133	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-49
25371658-3	2014	Potentiometric studies have been carried out on complexes of Schiff base (BHMQMHI) with Cu(II), Co(II), and Ni(II).	Schiff Bases	61-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-101
25371658-3	2014	Potentiometric studies have been carried out on complexes of Schiff base (BHMQMHI) with Cu(II), Co(II), and Ni(II).	bhmqmhi	74-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-101
25371658-5	2014	Metal-ligand stability constants fall in the order of Cu(II) &gt; Co(II) &gt; Ni(II) which is in agreement with those reported by Irving stability order.	Metals	0-5	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-72
25371658-5	2014	Metal-ligand stability constants fall in the order of Cu(II) &gt; Co(II) &gt; Ni(II) which is in agreement with those reported by Irving stability order.	cu(ii)	54-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-72
25371658-5	2014	Metal-ligand stability constants fall in the order of Cu(II) &gt; Co(II) &gt; Ni(II) which is in agreement with those reported by Irving stability order.	Nickel(2+)	78-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-72
24900965-2	2014	Activation of COX-1 and COX-2 results in increased levels of prostaglandins and the induction of angiogenic, antiapoptotic and inflammatory processes.	Prostaglandins	61-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
24209633-0	2014	Aspirin inhibits lipopolysaccharide-induced COX-2 expression and PGE2 production in porcine alveolar macrophages by modulating protein kinase C and protein tyrosine phosphatase activity.	Aspirin	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-49
24209633-1	2014	Aspirin has been demonstrated to be effective in inhibiting COX-2 and PGE(2) in Alveolar macrophages (AMs).	Aspirin	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-65
24209633-3	2014	In the present study, we found that pretreatment with aspirin inhibited LPS-induced COX-2 and PGE(2) upregulation, IkappaBalpha degradation, NFkappaB activation and the increase of PKC activity, but elevated LPS-induced the decrease of PTP activity.	Aspirin	54-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-89
24282256-2	2014	Aspirin inhibits several pathways mediated by NF-kappaB, COX-2, or their targets that are important in multiple myeloma pathogenesis.	Aspirin	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-62
24282256-12	2014	This prospective study of aspirin use and multiple myeloma supports an etiologic role for aspirin-inhibited (i.e., NF-kappaB- or COX-2 mediated) pathways.	Aspirin	90-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-134
24854838-5	2014	RESULTS: Celecoxib enhances radiation cytotoxicity in C666-1 and CNE-1 nasopharyngeal carcinoma cells that expressed high COX-2 but not in CNE-2 cells that expressed low COX-2.	Celecoxib	9-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-127
24854838-5	2014	RESULTS: Celecoxib enhances radiation cytotoxicity in C666-1 and CNE-1 nasopharyngeal carcinoma cells that expressed high COX-2 but not in CNE-2 cells that expressed low COX-2.	Celecoxib	9-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	170-175
24059588-2	2014	Elevated production of prostanoids from the constitutive (COX-1) or inducible (COX-2) cyclo-oxygenases has been involved in the alterations in vascular function, structure and mechanical properties observed in cardiovascular diseases, including hypertension.	Prostaglandins	23-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-84
25258584-2	2014	Previous studies showed that the selective cyclooxygenase (COX)-2 inhibitor celecoxib can enhance the tumor response to radiotherapy.	Celecoxib	76-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-65
24372204-4	2014	Both, ectoine and lauryl-ectoine considerably decreased lipopolysaccharide (LPS)-induced interleukin (IL)- 1, IL-6, tumor necrosis factor (TNF)- alpha, and cyclooxygenase (COX)-2 gene expression in macrophages as well as TNF-alpha- induced IL-1, IL-6 and COX-2 expression in RISM cells.	ectoine	6-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	156-178
24372204-4	2014	Both, ectoine and lauryl-ectoine considerably decreased lipopolysaccharide (LPS)-induced interleukin (IL)- 1, IL-6, tumor necrosis factor (TNF)- alpha, and cyclooxygenase (COX)-2 gene expression in macrophages as well as TNF-alpha- induced IL-1, IL-6 and COX-2 expression in RISM cells.	ectoine	6-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	255-260
24372204-4	2014	Both, ectoine and lauryl-ectoine considerably decreased lipopolysaccharide (LPS)-induced interleukin (IL)- 1, IL-6, tumor necrosis factor (TNF)- alpha, and cyclooxygenase (COX)-2 gene expression in macrophages as well as TNF-alpha- induced IL-1, IL-6 and COX-2 expression in RISM cells.	lauryl-ectoine	18-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	156-178
24372204-4	2014	Both, ectoine and lauryl-ectoine considerably decreased lipopolysaccharide (LPS)-induced interleukin (IL)- 1, IL-6, tumor necrosis factor (TNF)- alpha, and cyclooxygenase (COX)-2 gene expression in macrophages as well as TNF-alpha- induced IL-1, IL-6 and COX-2 expression in RISM cells.	lauryl-ectoine	18-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	255-260
24413338-0	2014	Chronic arsenic exposure and angiogenesis in human bronchial epithelial cells via the ROS/miR-199a-5p/HIF-1alpha/COX-2 pathway.	Arsenic	8-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-118
24413338-0	2014	Chronic arsenic exposure and angiogenesis in human bronchial epithelial cells via the ROS/miR-199a-5p/HIF-1alpha/COX-2 pathway.	Reactive Oxygen Species	86-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-118
24394438-6	2014	The UV-visible-near IR spectroscopies and magnetic moment data for the Co(II) and Ni(II) complexes indicated a tetragonal distorted coordination geometry for both metal centres.	Metals	163-168	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-88
23985482-0	2014	Synthesis and spectral characterization of Schiff base complexes of Cu(II), Co(II), Zn(II) and VO(IV) containing 4-(4-aminophenyl)morpholine derivatives: antimicrobial evaluation and anticancer studies.	Schiff Bases	43-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-82
23985482-0	2014	Synthesis and spectral characterization of Schiff base complexes of Cu(II), Co(II), Zn(II) and VO(IV) containing 4-(4-aminophenyl)morpholine derivatives: antimicrobial evaluation and anticancer studies.	4-Morpholinoaniline	113-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-82
23985482-2	2014	The complexes are of the type M(X-MPMP)2 [where M=Cu(II), Co(II)), Zn(II), or VO(IV); MPMP=2-[(4 morpholinophenyl imino) methyl] 4-X-phenol, X=Cl, (L1H), X=Br (L2H)].	x-mpmp	32-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-64
24232001-5	2014	Pre- and coadministration of paeoniflorin significantly reduced the severity of colitis and resulted in downregulation of several inflammatory parameters in the colon, including the activity of myeloperoxidase (MPO), the levels of TNF-alpha and IL-6, and the mRNA expression of proinflammatory mediators (MCP-1, Cox2, IFN-gamma, TNF-alpha, IL-6, and IL-17).	peoniflorin	29-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	312-316
24460806-2	2014	We hypothesized that the COX-2 inhibitor celecoxib alters atrial electrophysiology, and thus promotes the development of AF.	Celecoxib	41-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-30
24401212-0	2014	Hydroxytyrosol suppresses MMP-9 and COX-2 activity and expression in activated human monocytes via PKCalpha and PKCbeta1 inhibition.	3,4-dihydroxyphenylethanol	0-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-41
24744691-0	2014	Evaluation of DNA Binding, Cleavage, and Cytotoxic Activity of Cu(II), Co(II), and Ni(II) Schiff Base Complexes of 1-Phenylindoline-2,3-dione with Isonicotinohydrazide.	1-Phenylisatin	115-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-76
24744691-0	2014	Evaluation of DNA Binding, Cleavage, and Cytotoxic Activity of Cu(II), Co(II), and Ni(II) Schiff Base Complexes of 1-Phenylindoline-2,3-dione with Isonicotinohydrazide.	(1,1-difluoro-1-((6-carboxy)naphth-2-yl))methylphosphonic acid	147-167	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-76
24744691-1	2014	One new series of Cu(II), Co(II), and Ni(II) Schiff base complexes was prepared through the condensation reaction between 1-phenylindoline-2,3-dione with isonicotinohydrazide followed by metalation, respectively.	1-Phenylisatin	122-148	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-31
24744691-1	2014	One new series of Cu(II), Co(II), and Ni(II) Schiff base complexes was prepared through the condensation reaction between 1-phenylindoline-2,3-dione with isonicotinohydrazide followed by metalation, respectively.	(1,1-difluoro-1-((6-carboxy)naphth-2-yl))methylphosphonic acid	154-174	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-31
25614733-0	2014	DNA Binding Test, X-Ray Crystal Structure, Spectral Studies, TG-DTA, and Electrochemistry of [CoX 2 (dmdphphen)] (Dmdphphen Is 2,9-Dimethyl-4,7-diphenyl-1,10-phenanthroline, X = Cl, and NCS) Complexes.	dmdphphen	101-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-99
25614733-0	2014	DNA Binding Test, X-Ray Crystal Structure, Spectral Studies, TG-DTA, and Electrochemistry of [CoX 2 (dmdphphen)] (Dmdphphen Is 2,9-Dimethyl-4,7-diphenyl-1,10-phenanthroline, X = Cl, and NCS) Complexes.	dmdphphen	114-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-99
25614733-5	2014	The two complexes exhibit a quasireversible one-electron response at -550 and 580 mV versus Cp2Fe/Cp2Fe(+), which has been assigned to Co(I)/Co(II) and Co(II)/Co(III) couples.	cp2fe	92-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	141-147
25614733-5	2014	The two complexes exhibit a quasireversible one-electron response at -550 and 580 mV versus Cp2Fe/Cp2Fe(+), which has been assigned to Co(I)/Co(II) and Co(II)/Co(III) couples.	cp2fe	92-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-158
25614733-5	2014	The two complexes exhibit a quasireversible one-electron response at -550 and 580 mV versus Cp2Fe/Cp2Fe(+), which has been assigned to Co(I)/Co(II) and Co(II)/Co(III) couples.	cp2fe(+)	98-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	141-147
25614733-5	2014	The two complexes exhibit a quasireversible one-electron response at -550 and 580 mV versus Cp2Fe/Cp2Fe(+), which has been assigned to Co(I)/Co(II) and Co(II)/Co(III) couples.	cp2fe(+)	98-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-158
24209633-4	2014	The PKC inhibitor calphostin C dramatically reduced the COX-2 mRNA and PGE(2) levels, but the PTP inhibitor peroxovanadium (POV) significantly increased the COX-2 mRNA and PGE(2) levels.	peroxovanadium	108-122	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	157-162
24209633-5	2014	Furthermore, the PTP inhibitor mitigated the inhibitory effect of aspirin on COX-2 and PGE(2) upregulation and NF-kappaB activation, whereas the PKC inhibitor enhanced the inhibitory effects of aspirin on the production of COX-2 and PGE(2).	Aspirin	66-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-82
24520227-0	2014	Synergistic Effect of COX-2 Inhibitor on Paclitaxel-Induced Apoptosis in the Human Ovarian Cancer Cell Line OVCAR-3.	Paclitaxel	41-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-27
24854838-6	2014	The radiosensitization of celecoxib in C666-1 cells disappeared after the COX-2 knocked down, while the CNE-2 cells were radiosensitized by celecoxib after the transfection of COX-2.	Celecoxib	26-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
24854838-6	2014	The radiosensitization of celecoxib in C666-1 cells disappeared after the COX-2 knocked down, while the CNE-2 cells were radiosensitized by celecoxib after the transfection of COX-2.	Celecoxib	26-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	176-181
24712550-0	2014	In vivo tracking of novel SPIO-Molday ION rhodamine-B -labeled human bone marrow-derived mesenchymal stem cells after lentivirus- mediated COX-2 silencing: a preliminary study.	rhodamine B	42-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-144
24251671-15	2014	Evidence is provided that exogenous melatonin and that converted from its precursor, L-tryptophan, attenuates acute gastric lesions and accelerates ulcer healing via interaction with MT2 receptors due to an enhancement of gastric microcirculation, probably mediated by NO and PG derived from NOS and COX-1 and COX-2 overexpression and activity.	Melatonin	36-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	310-315
24251671-15	2014	Evidence is provided that exogenous melatonin and that converted from its precursor, L-tryptophan, attenuates acute gastric lesions and accelerates ulcer healing via interaction with MT2 receptors due to an enhancement of gastric microcirculation, probably mediated by NO and PG derived from NOS and COX-1 and COX-2 overexpression and activity.	Tryptophan	85-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	310-315
23298324-11	2014	Plasma concentration of meloxicam was maintained above its IC50 concentration required for COX-2 inhibition for 23 days.	Meloxicam	24-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-96
24176919-8	2014	Conditional complex stability constant determinations for Dp44mT with Cu(II), Co(II), Fe(II), Ni(II) and Zn(II) revealed that the metal-to-ligand ratio is 1:1 in [Cu(II)Dp44mT] complex, while for Co(II), Fe(II) and Ni(II) is 1:2.	Metals	130-135	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	196-202
24512453-2	2014	By direct measurement of cellular Hg(II) uptake in model iron and sulfate reducing bacteria, we have observed that specific trace metals, such as Zn(II) and Cd(II), inhibit uptake and methylation in these organisms, whereas other metals, such as Ni(II), Co(II), or Fe(II), do not.	Zinc	146-152	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	254-260
24512453-2	2014	By direct measurement of cellular Hg(II) uptake in model iron and sulfate reducing bacteria, we have observed that specific trace metals, such as Zn(II) and Cd(II), inhibit uptake and methylation in these organisms, whereas other metals, such as Ni(II), Co(II), or Fe(II), do not.	cd(ii)	157-163	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	254-260
25477992-5	2014	Platycodin D showed favorable cytotoxic effects on the H520 cells, and also dose-dependently decreased the tumor volumes and weights with increases of apoptotic cells (caspase-3 and PARP immunopositive cells), iNOS and TNF-alpha immunoreactivities, decreases of COX-2 immunoreactivities in tumor masses.	platycodin D	0-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	262-267
24365321-21	2014	Selective inhibition of COX-2 by drugs such as rofecoxib (Vioxx) and valdecoxib (Bextra) results in specific inhibition of synthesis of prostaglandins participating in inflammation and was found to lead to vascular complications including an increased risk for stroke.	rofecoxib	47-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
24365321-21	2014	Selective inhibition of COX-2 by drugs such as rofecoxib (Vioxx) and valdecoxib (Bextra) results in specific inhibition of synthesis of prostaglandins participating in inflammation and was found to lead to vascular complications including an increased risk for stroke.	rofecoxib	58-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
24365321-21	2014	Selective inhibition of COX-2 by drugs such as rofecoxib (Vioxx) and valdecoxib (Bextra) results in specific inhibition of synthesis of prostaglandins participating in inflammation and was found to lead to vascular complications including an increased risk for stroke.	valdecoxib	69-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
24365321-21	2014	Selective inhibition of COX-2 by drugs such as rofecoxib (Vioxx) and valdecoxib (Bextra) results in specific inhibition of synthesis of prostaglandins participating in inflammation and was found to lead to vascular complications including an increased risk for stroke.	valdecoxib	81-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
24365321-21	2014	Selective inhibition of COX-2 by drugs such as rofecoxib (Vioxx) and valdecoxib (Bextra) results in specific inhibition of synthesis of prostaglandins participating in inflammation and was found to lead to vascular complications including an increased risk for stroke.	Prostaglandins	136-150	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
24176919-7	2014	A 50-times higher Co(II) extracellular concentration hindered the Cu(II) uptake almost completely and a 10-times higher Co(II) concentration already decreased the Dp44mT-mediated Cu toxicity.	cu(ii)	66-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-24
24176919-8	2014	Conditional complex stability constant determinations for Dp44mT with Cu(II), Co(II), Fe(II), Ni(II) and Zn(II) revealed that the metal-to-ligand ratio is 1:1 in [Cu(II)Dp44mT] complex, while for Co(II), Fe(II) and Ni(II) is 1:2.	di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone	58-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-84
24176919-8	2014	Conditional complex stability constant determinations for Dp44mT with Cu(II), Co(II), Fe(II), Ni(II) and Zn(II) revealed that the metal-to-ligand ratio is 1:1 in [Cu(II)Dp44mT] complex, while for Co(II), Fe(II) and Ni(II) is 1:2.	di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone	58-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	196-202
25404377-4	2014	Further gene expression studies showed significant down-regulation of AKT1/2/3, p-AKT, and COX-2 proteins including up-regulation of active caspase-3 in ME treated Hep G2 cells.	methionylglutamic acid	153-155	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-96
24558308-0	2014	Korean Red Ginseng water extract inhibits COX-2 expression by suppressing p38 in acrolein-treated human endothelial cells.	Water	19-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47
24558308-0	2014	Korean Red Ginseng water extract inhibits COX-2 expression by suppressing p38 in acrolein-treated human endothelial cells.	Acrolein	81-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47
24558308-5	2014	Acrolein-induced COX-2 expression was accompanied by increased levels of phosphorylated p38 in HUVECs and KRG inhibited COX-2 expression in HUVECs.	Acrolein	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22
24558308-5	2014	Acrolein-induced COX-2 expression was accompanied by increased levels of phosphorylated p38 in HUVECs and KRG inhibited COX-2 expression in HUVECs.	Acrolein	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-125
24558308-6	2014	These results suggest that KRG suppresses acrolein-induced COX-2 expression via inhibition of the p38 mitogen-activated protein kinase signaling pathway.	Acrolein	42-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-64
25421594-0	2014	Water-extracted Ampelopsis brevipedunculata downregulates IL-1beta,CCL5, and COX-2 expression via inhibition of PKC-mediated JNK/NF-kappaB signaling pathways in human monocytic cells.	Water	0-5	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-82
25421594-8	2014	Collectively, our data showed that water-extracted A.bre inhibited the protein kinase C-JNKs/NF-kappaB signaling pathways, resulting in the suppression of IL-1beta, CCL-5, and COX-2 expression.	Water	35-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	176-181
24254970-6	2014	We also confirm, that PDX is an anti-aggregatory and anti-inflammatory agent by inhibiting both cyclooxygenase-1 and -2 (COX-1 and COX-2, E.C.	10,17-dihydroxydocosa-4,7,11,13,15,19-hexaenoic acid	22-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-136
25612650-9	2014	Also, endothelium removal, and COX-2 and NAD(P)H oxidase inhibitors attenuate the LXA4-induced contraction.	lipoxin A4	82-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-36
24729783-7	2014	In conclusion, the anticancer effects of combined gamma -tocotrienol and PPAR gamma antagonists treatment in PPAR gamma negative/silenced breast cancer cells are mediated through PPAR gamma -independent mechanisms that are associated with a downregulation in COX-2, PGDS, and PGD2 synthesis.	plastochromanol 8	50-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	259-264
24220687-0	2014	Sanguinarine inhibits invasiveness and the MMP-9 and COX-2 expression in TPA-induced breast cancer cells by inducing HO-1 expression.	sanguinarine	0-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-58
24220687-0	2014	Sanguinarine inhibits invasiveness and the MMP-9 and COX-2 expression in TPA-induced breast cancer cells by inducing HO-1 expression.	Tetradecanoylphorbol Acetate	73-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-58
24220687-5	2014	The results showed that sanguinarine inhibited TPA-induced MMP-9 and COX-2 mRNA and protein expression in a dose-dependent manner at non-cytotoxic concentrations.	sanguinarine	24-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-74
24220687-5	2014	The results showed that sanguinarine inhibited TPA-induced MMP-9 and COX-2 mRNA and protein expression in a dose-dependent manner at non-cytotoxic concentrations.	Tetradecanoylphorbol Acetate	47-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-74
23723142-9	2014	Moreover, safety concerns related to alternative medications such as acetaminophen and selective COX-2 inhibitors may influence users of these drugs to switch to aspirin and NSAIDs.	Aspirin	162-169	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
24286396-2	2014	The ability of these compounds to inhibit cyclooxygenase (COX-1 and 2) enzyme has been determined in-vitro; the results indicated that quinazolinone derivatives were selective towards COX-2 rather than COX-1.	Quinazolinones	135-148	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	184-189
24286396-3	2014	Among the quinazolinone derivatives tested, compound 32 showed better inhibition against COX-2 when compared with Celecoxib.	Quinazolinones	10-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-94
24976682-5	2014	trans-Resveratrol was identified as an inhibitor of COX-1 (IC50 = 2.27 muM) and COX-2 (IC50 = 3.40 muM).	Resveratrol	0-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-85
24976682-6	2014	Red wine as a complex mixture is a powerful inhibitor of COX-1, COX-2, and 5-LOX, the enzymes involved in eicosanoid biosynthetic pathway.	Eicosanoids	106-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-69
24729783-6	2014	Western blot and qRT-PCR studies showed that the growth inhibitory effects of combined gamma -tocotrienol and PPAR gamma antagonist treatment decreased cyclooxygenase (COX-2), prostaglandin synthase (PGDS), and prostaglandin D2 (PGD2) synthesis.	plastochromanol 8	87-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	168-173
24239764-5	2014	IR spectra show that the ligands act in a bidentate manner and coordinates N4 donor groups of the ligands to Ni(II), Cu(II) and Co(II) ions.	Nickel(2+)	109-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	128-134
24231744-0	2014	Highly stable water dispersible calix[4]pyrrole octa-hydrazide protected gold nanoparticles as colorimetric and fluorometric chemosensors for selective signaling of Co(II) ions.	Water	14-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	165-171
24231744-0	2014	Highly stable water dispersible calix[4]pyrrole octa-hydrazide protected gold nanoparticles as colorimetric and fluorometric chemosensors for selective signaling of Co(II) ions.	calix[4]pyrrole octa-hydrazide	32-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	165-171
24231744-4	2014	Ion sensing property of CPOH-AuNps has been investigated for various metal ions Pb(II), Cd(II), Mn(II), Fe(III), Ni(II), Zn(II), Hg(II), Co(II) and Cu(II) by colorimetry and spectrofluorimetry.	cpoh	24-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-143
24231744-5	2014	Among all the metal ions investigated, only Co(II) ions gives sharp colour change from ruby red to blue and is easily detectable by naked-eye.	Metals	14-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-50
24231744-6	2014	CPOH-AuNps being fluorescent in nature also shows great sensitivity and selectivity for Co(II) ions.	cpoh	0-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-94
24239761-0	2014	Synthesis and characterization of Cu(II), Co(II) and Ni(II) complexes of a number of sulfadrug azodyes and their application for wastewater treatment.	Azo Compounds	95-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-48
24239761-3	2014	Cu(II), Co(II) and Ni(II) complexes of the prepared ligands have been synthesized and characterized by various spectroscopic techniques like IR, UV-Visible as well as magnetic and thermal (TG and DTA) measurements.	Thioguanine	189-191	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	8-14
24239761-3	2014	Cu(II), Co(II) and Ni(II) complexes of the prepared ligands have been synthesized and characterized by various spectroscopic techniques like IR, UV-Visible as well as magnetic and thermal (TG and DTA) measurements.	deoxythymidylyl-3'-5'-deoxyadenylate	196-199	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	8-14
24239764-0	2014	Spectroscopic and biological approach of Ni(II), Cu(II) and Co(II) complexes of 4-methoxy/ethoxybenzaldehyde thiosemicarbazone glyoxime.	Nickel(2+)	41-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-66
24239764-0	2014	Spectroscopic and biological approach of Ni(II), Cu(II) and Co(II) complexes of 4-methoxy/ethoxybenzaldehyde thiosemicarbazone glyoxime.	4-methoxy/ethoxybenzaldehyde	80-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-66
24239764-0	2014	Spectroscopic and biological approach of Ni(II), Cu(II) and Co(II) complexes of 4-methoxy/ethoxybenzaldehyde thiosemicarbazone glyoxime.	Thiosemicarbazones	109-126	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-66
24239764-0	2014	Spectroscopic and biological approach of Ni(II), Cu(II) and Co(II) complexes of 4-methoxy/ethoxybenzaldehyde thiosemicarbazone glyoxime.	glyoxal dioxime	127-135	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-66
24239764-5	2014	IR spectra show that the ligands act in a bidentate manner and coordinates N4 donor groups of the ligands to Ni(II), Cu(II) and Co(II) ions.	Folic Acid	75-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	128-134
25325542-1	2014	Based on the sensitive reaction of Co(II) and salicyl fluorone with the presence of cetylpyridinium bromide in basic solution, a new method of flow injection micelle-solubilized spectrophotometry was developed for the determination of cobalt.	hexadecylpyridinium bromide	84-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-41
25325542-1	2014	Based on the sensitive reaction of Co(II) and salicyl fluorone with the presence of cetylpyridinium bromide in basic solution, a new method of flow injection micelle-solubilized spectrophotometry was developed for the determination of cobalt.	Cobalt	235-241	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-41
24526951-2	2014	The Co(II) ion, situated on a twofold rotation axis, forms a complex with the crown-4 moiety of the 3,3"-[(1,7-dioxa-4,10-di-aza-cyclo-do-decane-4,10-di-yl)bis-(meth-ylene)]dibenzoate anion.	3,3"-[(1,7-dioxa-4,10-di-aza-cyclo-do-decane-4,10-di-yl)bis-(meth-ylene)]dibenzoate anion	100-189	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
24526951-3	2014	The dis-torted octahedral coordination sphere of the Co(II) ion is completed by two carboxyl-ate O atoms from two bridging intra-chain ligands.	carboxyl-ate o	84-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-59
24266650-1	2013	A Co(II) anilinosalen catalyst containing proton relays in the first coordination sphere has been synthesized that catalyzes the electrochemical production of hydrogen from acid in dichloromethane and acetonitrile solutions.	Hydrogen	159-167	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	2-8
24266650-1	2013	A Co(II) anilinosalen catalyst containing proton relays in the first coordination sphere has been synthesized that catalyzes the electrochemical production of hydrogen from acid in dichloromethane and acetonitrile solutions.	Methylene Chloride	181-196	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	2-8
24266650-1	2013	A Co(II) anilinosalen catalyst containing proton relays in the first coordination sphere has been synthesized that catalyzes the electrochemical production of hydrogen from acid in dichloromethane and acetonitrile solutions.	acetonitrile	201-213	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	2-8
24266650-3	2013	We show that both coordinated anilido groups of the neutral Co(II) complex can be protonated into aniline form.	aniline	98-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-66
24304351-3	2013	It has been established from susceptibility results that the switching between diamagnetic and paramagnetic phases emanates from electron transfer between low spin Fe(II) and Co(III), resulting in low spin Fe(III) (S = 1/2) and high spin Co(II) (S = 3/2).	ammonium ferrous sulfate	164-170	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	238-244
24231650-3	2013	In this study, we screened novel anacardic acid derivatives as modulators of human 5-LOX and COX-2 activity.	anacardic acid	33-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-98
24012435-3	2013	We demonstrated that PL stimulation induces a transient increase of the inflammatory response in quiescent human osteoblasts, via NF-kB activation, COX-2 induction, PGE2 production and secretion of pro-inflammatory cytokines.	pl	21-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	148-153
24195792-3	2013	We found that the anti-inflammatory cascade of eriodictyol is mediated through the Toll-like Receptor (TLR)4/CD14, p38 mitogen-activated protein kinases (MAPK), extracellular-signal-regulated kinase (ERK), Jun-N terminal kinase (JNK), and cyclooxygenase (COX)-2 pathway.	eriodictyol	47-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	239-261
23792775-4	2013	Here, we examined mechanisms of chemoprotection by NAC against Cd(II), Co(II), and Cr(VI) in human cells.	Acetylcysteine	51-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-76
23792775-9	2013	Suppression of Co(II) uptake resulted from a rapid formation of Co(II)-NAC conjugates that were unable to enter cells.	Acetylcysteine	71-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-21
23792775-9	2013	Suppression of Co(II) uptake resulted from a rapid formation of Co(II)-NAC conjugates that were unable to enter cells.	Acetylcysteine	71-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-70
23792775-11	2013	Good clinical safety and effectiveness in Co(II) sequestration suggest that NAC could be useful in the prevention of tissue accumulation and toxic effects of Co ions released by cobalt-chromium hip prostheses.	Acetylcysteine	76-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-48
24496160-12	2014	CONCLUSION: Overexpression of COX-2 and TGF-beta1 is an independent predictor for poor outcome of interferon and ribavirin therapy and these might be useful markers for the response to treatment.	Ribavirin	113-122	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-35
24279370-1	2013	We introduce the novel Co4O4 complex [Co(II)4(hmp)4(mu-OAc)2(mu2-OAc)2(H2O)2] (1) (hmp = 2-(hydroxymethyl)pyridine) as the first Co(II)-based cubane water oxidation catalyst.	co4o4	23-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-44
24279370-1	2013	We introduce the novel Co4O4 complex [Co(II)4(hmp)4(mu-OAc)2(mu2-OAc)2(H2O)2] (1) (hmp = 2-(hydroxymethyl)pyridine) as the first Co(II)-based cubane water oxidation catalyst.	(mu2-oac)2(h2o)2	60-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-44
24279370-1	2013	We introduce the novel Co4O4 complex [Co(II)4(hmp)4(mu-OAc)2(mu2-OAc)2(H2O)2] (1) (hmp = 2-(hydroxymethyl)pyridine) as the first Co(II)-based cubane water oxidation catalyst.	2-PYRIDINEMETHANOL	89-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-44
24279370-1	2013	We introduce the novel Co4O4 complex [Co(II)4(hmp)4(mu-OAc)2(mu2-OAc)2(H2O)2] (1) (hmp = 2-(hydroxymethyl)pyridine) as the first Co(II)-based cubane water oxidation catalyst.	Water	149-154	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-44
24279370-4	2013	The Co(II) core combines robustness and stability with flexibility through a new type of water-oxidation mechanism via mobile ligands.	Water	89-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
24224463-1	2013	We report the magnetic structure of the two magnetically ordered phases of Co3(OH)2(C4O4)2, a coordination polymer that consists of a triangular framework decorated with anisotropic Co(II) ions.	co3(oh)2(c4o4)2	75-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	182-188
24363623-2	2013	The photocatalytic bleaching of cationic dye methylene blue was carried out spectrometrically on irradiation of UV light using Cu(II), Ni(II), and Co(II) complexes of (2E)-2-[(2E)-3-phenylprop-2-en-1-ylidene]hydrazinecarbothioamide (HL).	Methylene Blue	45-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-153
24363623-2	2013	The photocatalytic bleaching of cationic dye methylene blue was carried out spectrometrically on irradiation of UV light using Cu(II), Ni(II), and Co(II) complexes of (2E)-2-[(2E)-3-phenylprop-2-en-1-ylidene]hydrazinecarbothioamide (HL).	Cinnamaldehyde thiosemicarbazone	167-231	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-153
24363623-2	2013	The photocatalytic bleaching of cationic dye methylene blue was carried out spectrometrically on irradiation of UV light using Cu(II), Ni(II), and Co(II) complexes of (2E)-2-[(2E)-3-phenylprop-2-en-1-ylidene]hydrazinecarbothioamide (HL).	histidylleucine	233-235	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-153
24089379-7	2013	Ibuprofen treatment blocked exercise-induced increases in COX-1 and COX-2-derived prostanoids but also resulted in off-target reductions in leukotriene biosynthesis, and a diminished proresolving lipid mediator response.	Ibuprofen	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-73
24089379-7	2013	Ibuprofen treatment blocked exercise-induced increases in COX-1 and COX-2-derived prostanoids but also resulted in off-target reductions in leukotriene biosynthesis, and a diminished proresolving lipid mediator response.	Prostaglandins	82-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-73
24383977-2	2013	Etoricoxib, a cox-2 inhibitor NSAID, has been shown to be a safe alternative in these patients.	Etoricoxib	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
24035605-7	2013	RESULT(S): This study showed a marked increase in the key PG biosynthesis enzymes Cox-2, mPGES-1, mPGES-2, cPGES, and AKR-1C3 in ectopic endometrial tissue of women with endometriosis, particularly in the earliest and most active stages of the disease, without a noticeable change in the expression of the PG catabolic enzyme 15-hydroxyprostaglandin dehydrogenase.	Prostaglandins	58-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
24570829-0	2013	Synthesis, Anti-Inflammatory and Anti- Nociceptive Activities and Cytotoxic Effect of Novel Thiazolidin-4-ones Derivatives as Selective Cyclooxygenase (COX-2) Inhibitors.	thiazolidin-4-ones	92-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-157
24570829-1	2013	OBJECTIVE(S): Nowadays, COX - 2 inhibitors such as valdecoxib are removed from the market because of their cardiovascular toxicity and their potential to increase the risk of strokes.	valdecoxib	51-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-31
24570829-10	2013	The COX-2 inhibition potency and selectivity index for test compounds 2a-b were as follows; celecoxib &gt; 2b &gt; 2a.	Celecoxib	92-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
24064800-4	2013	Furthermore, caudatin treatment resulted in a decrease in beta-catenin and GSK3beta in SMMC-7721 cells, with a concomitant reduction in metastatic capability and expression of Wnt signaling pathway targeted genes including cox-2, mmp-2 and mmp-9.	caudatin	13-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	223-228
24081326-6	2013	CB82 and CB91 down-regulated the expression of phosphorylated proteins like NF-kappaB, ERK, Akt and the enzyme Cox-2, CB91 blocked the expression of the CB2 receptor and its inhibitory effect was CB2 receptor mediated.	cb82	0-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	111-116
24027177-3	2013	Etodolac is a cyclooxygenase (COX)-2 inhibitor that belongs to the class of nonsteroidal anti-inflammatory drugs (NSAIDs).	Etodolac	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-36
24100466-0	2013	Overcoming paclitaxel resistance in uterine endometrial cancer using a COX-2 inhibitor.	Paclitaxel	11-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-76
24100466-2	2013	In the present study, we investigated the association between COX-2 and MDR1 expression in endometrial cancers and evaluated the effects of the COX-2 inhibitor, etodolac, in combination with paclitaxel on paclitaxel-resistant endometrial cancer cells.	Etodolac	161-169	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	144-149
24100466-2	2013	In the present study, we investigated the association between COX-2 and MDR1 expression in endometrial cancers and evaluated the effects of the COX-2 inhibitor, etodolac, in combination with paclitaxel on paclitaxel-resistant endometrial cancer cells.	Paclitaxel	205-215	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	144-149
24100466-11	2013	In OMC-2 cells, COX-2 and MDR1 mRNA levels were significantly upregulated by paclitaxel treatment and downregulated by co-administration with etodolac.	Paclitaxel	77-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-21
24100466-11	2013	In OMC-2 cells, COX-2 and MDR1 mRNA levels were significantly upregulated by paclitaxel treatment and downregulated by co-administration with etodolac.	Etodolac	142-150	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-21
24100466-12	2013	In OMC-2P cells, COX-2 mRNA expression was also significantly upregulated by paclitaxel treatment and tended to be downregulated by co-administration with etodolac.	Paclitaxel	77-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22
24100466-12	2013	In OMC-2P cells, COX-2 mRNA expression was also significantly upregulated by paclitaxel treatment and tended to be downregulated by co-administration with etodolac.	Etodolac	155-163	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22
24100466-17	2013	These findings suggest that paclitaxel resistance may be associated with COX-2 and MDR1 expression in cancer cells.	Paclitaxel	28-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-78
24100466-18	2013	Co-administration of COX-2 inhibitors and paclitaxel may have a key role in modulating or overcoming paclitaxel resistance in endometrial cancers.	Paclitaxel	101-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-26
24255997-3	2013	Selective inhibition of cyclo-oxygenase-2 (COX)-2 could produce a relative reduction in endothelial production of prostacyclin, while leaving the platelet production of thromboxane A2 (TXA2 ) intact.	Epoprostenol	114-126	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-49
24255997-7	2013	RESULTS: Selective inhibition of COX-2 could produce a relative reduction in endothelial production of prostacyclin, while leaving the platelet production of TXA2 intact.	Epoprostenol	103-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-38
24255720-2	2013	The level of reactive oxygen species is regulated by a number of enzymes and physiological antioxidants, including HO-1, Sod2, catalase and COX-2, etc.	Reactive Oxygen Species	13-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-145
24068677-4	2013	We found that Co(II) showed almost 8 times higher accumulation than Ni(II) in H460 cells but caused a less efficient activation of the transcriptional factor p53 as measured by its accumulation, Ser15 phosphorylation, and target gene expression.	Nickel(2+)	68-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-20
24068677-6	2013	Co(II)-treated cells continued DNA replication at internal doses that caused massive apoptosis by Ni(II).	Nickel(2+)	98-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
24068677-12	2013	Thus, carcinogenicity of soluble Co(II) could be related to high survival of metal-loaded cells, which permits accumulation of genetic and epigenetic abnormalities.	Metals	77-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-39
23999614-2	2013	We found that the two Co(I) species were oxidized by these sulfur-containing compounds to Co(II) forms: oxidation by excess thiosulfate leads to penta-coordinate complexes and oxidation by excess sulfite or dithionite leads to hexa-coordinate Co(II)-SO2(-) complexes.	NAD	22-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-96
23999614-2	2013	We found that the two Co(I) species were oxidized by these sulfur-containing compounds to Co(II) forms: oxidation by excess thiosulfate leads to penta-coordinate complexes and oxidation by excess sulfite or dithionite leads to hexa-coordinate Co(II)-SO2(-) complexes.	NAD	22-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	243-249
23999614-2	2013	We found that the two Co(I) species were oxidized by these sulfur-containing compounds to Co(II) forms: oxidation by excess thiosulfate leads to penta-coordinate complexes and oxidation by excess sulfite or dithionite leads to hexa-coordinate Co(II)-SO2(-) complexes.	Sulfur	59-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-96
23999614-2	2013	We found that the two Co(I) species were oxidized by these sulfur-containing compounds to Co(II) forms: oxidation by excess thiosulfate leads to penta-coordinate complexes and oxidation by excess sulfite or dithionite leads to hexa-coordinate Co(II)-SO2(-) complexes.	Sulfur	59-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	243-249
23999614-2	2013	We found that the two Co(I) species were oxidized by these sulfur-containing compounds to Co(II) forms: oxidation by excess thiosulfate leads to penta-coordinate complexes and oxidation by excess sulfite or dithionite leads to hexa-coordinate Co(II)-SO2(-) complexes.	Thiosulfates	124-135	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-96
23999614-2	2013	We found that the two Co(I) species were oxidized by these sulfur-containing compounds to Co(II) forms: oxidation by excess thiosulfate leads to penta-coordinate complexes and oxidation by excess sulfite or dithionite leads to hexa-coordinate Co(II)-SO2(-) complexes.	Thiosulfates	124-135	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	243-249
23999614-2	2013	We found that the two Co(I) species were oxidized by these sulfur-containing compounds to Co(II) forms: oxidation by excess thiosulfate leads to penta-coordinate complexes and oxidation by excess sulfite or dithionite leads to hexa-coordinate Co(II)-SO2(-) complexes.	PENTA	145-150	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-96
23999614-2	2013	We found that the two Co(I) species were oxidized by these sulfur-containing compounds to Co(II) forms: oxidation by excess thiosulfate leads to penta-coordinate complexes and oxidation by excess sulfite or dithionite leads to hexa-coordinate Co(II)-SO2(-) complexes.	Sulfites	196-203	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-96
23999614-2	2013	We found that the two Co(I) species were oxidized by these sulfur-containing compounds to Co(II) forms: oxidation by excess thiosulfate leads to penta-coordinate complexes and oxidation by excess sulfite or dithionite leads to hexa-coordinate Co(II)-SO2(-) complexes.	Dithionite	207-217	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-96
24002675-1	2013	The mononuclear Co(II) complex CoBr (dmph = 2,9-dimethyl-1,10-phenanthroline) was obtained and X-ray structurally characterized as a distorted tetrahedron environment that is responsible for the moderately strong positive anisotropy of high spin Co(II).	cobr	31-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-22
24002675-1	2013	The mononuclear Co(II) complex CoBr (dmph = 2,9-dimethyl-1,10-phenanthroline) was obtained and X-ray structurally characterized as a distorted tetrahedron environment that is responsible for the moderately strong positive anisotropy of high spin Co(II).	cobr	31-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	246-252
24002675-1	2013	The mononuclear Co(II) complex CoBr (dmph = 2,9-dimethyl-1,10-phenanthroline) was obtained and X-ray structurally characterized as a distorted tetrahedron environment that is responsible for the moderately strong positive anisotropy of high spin Co(II).	Dexmethylphenidate Hydrochloride	37-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-22
24002675-1	2013	The mononuclear Co(II) complex CoBr (dmph = 2,9-dimethyl-1,10-phenanthroline) was obtained and X-ray structurally characterized as a distorted tetrahedron environment that is responsible for the moderately strong positive anisotropy of high spin Co(II).	Dexmethylphenidate Hydrochloride	37-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	246-252
24002675-1	2013	The mononuclear Co(II) complex CoBr (dmph = 2,9-dimethyl-1,10-phenanthroline) was obtained and X-ray structurally characterized as a distorted tetrahedron environment that is responsible for the moderately strong positive anisotropy of high spin Co(II).	neocuproine	44-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-22
24002675-1	2013	The mononuclear Co(II) complex CoBr (dmph = 2,9-dimethyl-1,10-phenanthroline) was obtained and X-ray structurally characterized as a distorted tetrahedron environment that is responsible for the moderately strong positive anisotropy of high spin Co(II).	neocuproine	44-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	246-252
24244288-10	2013	CONCLUSION: Our findings provide strong evidence that COX-2 and ITGA2 genetic defects might increase the risk of having aspirin insensitivity, especially for aspirin semi-resistance and in Chinese populations.	Aspirin	120-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-59
24244288-10	2013	CONCLUSION: Our findings provide strong evidence that COX-2 and ITGA2 genetic defects might increase the risk of having aspirin insensitivity, especially for aspirin semi-resistance and in Chinese populations.	Aspirin	158-165	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-59
24085292-4	2013	However, we found that long-term incubation with PIs (PS-341 or MG132) increased NF-kappaB-regulated gene expression such as COX-2, cIAP2, XIAP, and IL-8 in a dose- and time-dependent manner, which was mediated by phosphorylation of IkappaBalpha and its subsequent degradation via the alternative route, lysosome.	Bortezomib	54-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-130
24085292-4	2013	However, we found that long-term incubation with PIs (PS-341 or MG132) increased NF-kappaB-regulated gene expression such as COX-2, cIAP2, XIAP, and IL-8 in a dose- and time-dependent manner, which was mediated by phosphorylation of IkappaBalpha and its subsequent degradation via the alternative route, lysosome.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	64-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-130
24171470-0	2013	Structural and magnetic studies of a new Co(II) thiocyanato coordination polymer showing slow magnetic relaxations and a metamagnetic transition.	thiocyanato coordination polymer	48-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-47
23999828-0	2013	Auxiliary ligand-directed synthesis of a series of Cd(II)/Co(II) coordination polymers with methylenebis(3,5-dimethylpyrazole): syntheses, crystal structures, and properties.	cd(ii)	51-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
23999828-0	2013	Auxiliary ligand-directed synthesis of a series of Cd(II)/Co(II) coordination polymers with methylenebis(3,5-dimethylpyrazole): syntheses, crystal structures, and properties.	methylenebis(3,5-dimethylpyrazole)	92-126	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
24255720-9	2013	CoPP induces HO-1 and other oxidative stress-responsive genes expression, such as catalase, cytochrome c, Sod2, and COX-2, and decreases mitochondria-derived reactive oxygen species production, which are mediated partially by FOXO1.	COPP protocol	0-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-121
23838006-7	2013	Aldosterone stimulated phosphorylation of MAP kinases and increased expression of pro-inflammatory mediators ICAM-1, Cox-2 and PAI-1 in Deltakinase and K1648R cells, effects that were inhibited by eplerenone (mineralocorticoid receptor (MR) blocker).	Aldosterone	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-122
24105795-2	2013	In this study, DFT calculations were used to investigate their catalytic mechanism, to demonstrate that the initial active state was a Co(I) complex and that H2 was evolved in a heterolytic manner through the protonation of a Co(II)-hydride intermediate.	NAD	135-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	226-231
24105795-2	2013	In this study, DFT calculations were used to investigate their catalytic mechanism, to demonstrate that the initial active state was a Co(I) complex and that H2 was evolved in a heterolytic manner through the protonation of a Co(II)-hydride intermediate.	Hydrogen	158-160	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	226-231
24431307-3	2013	OBJECTIVES: The aim of this study was to check whether valdecoxib - a selective COX-2 inhibitor - inhibits VEGF and/or bFGF secretion in the presence of LPS or cobalt chloride in normal human microvascular endothelial cells (HMEC-1).	valdecoxib	55-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-85
23838006-7	2013	Aldosterone stimulated phosphorylation of MAP kinases and increased expression of pro-inflammatory mediators ICAM-1, Cox-2 and PAI-1 in Deltakinase and K1648R cells, effects that were inhibited by eplerenone (mineralocorticoid receptor (MR) blocker).	Eplerenone	197-207	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-122
24070708-7	2013	At concentrations of less than 10 mumol/L, JLU1124 inhibits p38 phosphorylation in a dose-dependent manner and significantly suppresses LPS-induced production of NO, IL-6 and TNF-alpha, and decreases the expressions of iNOS and COX-2 in RAW264.7 macrophages which indicate that JLU1124 has anti-inflammatory effects.	JLU1124	43-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	228-233
24180550-4	2013	The data showed salidroside inhibited LPS-induced NO and PGE2 production and reduced iNOS and COX-2 protein expression in RAW 264.7 macrophages.	rhodioloside	16-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-99
24009185-8	2013	HEK293 cells transiently expressing TxAS together with cyclooxygenase (COX)-1 or COX-2 produced both TxB2 and 12-HHT from arachidonic acid, while HEK293 cells expressing only COX-1 or COX-2 produced significant amounts of 12-HHT but no TxB2.	Thromboxane B2	101-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-86
24009185-8	2013	HEK293 cells transiently expressing TxAS together with cyclooxygenase (COX)-1 or COX-2 produced both TxB2 and 12-HHT from arachidonic acid, while HEK293 cells expressing only COX-1 or COX-2 produced significant amounts of 12-HHT but no TxB2.	12-hydroxy-5,8,10-heptadecatrienoic acid	110-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-86
23945567-2	2013	We have previously established that 11-oxo-eicosatetraenoic acid (oxo-ETE) and 15-oxo-ETE are COX-2/15-PGDH-derived metabolites.	11-oxoeicosatetraenoic acid	36-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-99
23945567-2	2013	We have previously established that 11-oxo-eicosatetraenoic acid (oxo-ETE) and 15-oxo-ETE are COX-2/15-PGDH-derived metabolites.	oxo-ete	66-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-99
23945567-2	2013	We have previously established that 11-oxo-eicosatetraenoic acid (oxo-ETE) and 15-oxo-ETE are COX-2/15-PGDH-derived metabolites.	15-oxo-5,8,11,13-eicosatetraenoic acid	79-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-99
23945567-10	2013	Therefore, this study has established that the COX-2/15-PGDH-derived eicosanoids 11-oxo- and 15-oxo-ETE enter target cells, that they inhibit cellular proliferation, and that their inhibitory effects are modulated by MRP exporters.	Eicosanoids	69-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
24180550-7	2013	These results suggest that salidroside suppresses NO and PGE2 production by inhibiting iNOS and COX-2 protein expression, level of [Ca2+](i), and activation of NF-kappaB signal transduction pathway.	rhodioloside	27-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-101
24000351-1	2013	The reaction site of the Co(II) porphyrin created by an amide group and coordinating 1,2-dimethylimidazole at the fifth site activated an O2 molecule, and then hydroxylated the meso-carbon of the ligand.	Amides	56-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-31
23945567-10	2013	Therefore, this study has established that the COX-2/15-PGDH-derived eicosanoids 11-oxo- and 15-oxo-ETE enter target cells, that they inhibit cellular proliferation, and that their inhibitory effects are modulated by MRP exporters.	11-oxo- and 15-oxo-ete	81-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
24640118-7	2013	Follow-up reactions, such as inhibition of platelet-dependent thromboxane formation and action, release of storage products such as VEGF or sphingosine-1-phosphate and acetylation of COX-2 with subsequent generation of antioncogenic lipid mediators, such as lipoxins, are also possible.	Lipoxins	258-266	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	183-188
24286132-14	2013	CONCLUSIONS: The present findings revealed that FN-fs are more potent than IL-1beta in exerting catabolic effects dependent on oxygen tension via iNOS and COX-2 upregulation.	Fenofibrate	48-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	155-160
24286132-14	2013	CONCLUSIONS: The present findings revealed that FN-fs are more potent than IL-1beta in exerting catabolic effects dependent on oxygen tension via iNOS and COX-2 upregulation.	Oxygen	127-133	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	155-160
24044877-3	2013	Additionally, the reactivities of Co(II) and Co(I) dppe complexes toward the Diels-Alder substrates isoprene and phenylacetylene were probed in gas-phase ion/molecule reactions (IMRs).	isoprene	100-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-40
24044877-3	2013	Additionally, the reactivities of Co(II) and Co(I) dppe complexes toward the Diels-Alder substrates isoprene and phenylacetylene were probed in gas-phase ion/molecule reactions (IMRs).	phenylacetylene	113-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-40
23306427-0	2013	The efficacy of rebamipide add-on therapy in arthritic patients with COX-2 selective inhibitor-related gastrointestinal events: a prospective, randomized, open-label blinded-endpoint pilot study by the GLORIA study group.	rebamipide	16-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-74
23306427-10	2013	Rebamipide might be a candidate for an option to prevent COX-2 selective inhibitor-induced upper GI events.	rebamipide	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-62
24427928-6	2013	The dichloromethane extract of privet leaves showed a considerable inhibitory effect against COX-1 and COX-2 enzyme activity.	Methylene Chloride	4-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-108
23922312-4	2013	The structures were similar to MSC spheres formed in cultures demonstrated by the increased expression of genes for inflammation-modulating factors TSG6, STC1, and COX2, a key enzyme in production of PGE2.	Dinoprostone	200-204	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	164-168
24101498-2	2013	The biochemical selection of manganese over iron presents a particularly intricate problem because manganese is generally present in cells at a lower concentration than iron, while also having a lower predicted complex stability according to the Irving-Williams series (Mn(II) &lt; Fe(II) &lt; Ni(II) &lt; Co(II) &lt; Cu(II) &gt; Zn(II)).	Manganese	99-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	306-312
24112144-0	2013	Synthesis, spectroscopic characterization, and determination of the solution association energy of the dimer [Co{N(SiMe3)2}2]2: magnetic studies of low-coordinate Co(II) silylamides [Co{N(SiMe3)2}2L] (L = PMe3, pyridine, and THF) and related species that reveal evidence of very large zero-field splittings.	co{n(sime3)2}2]2	110-126	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	163-169
24112144-0	2013	Synthesis, spectroscopic characterization, and determination of the solution association energy of the dimer [Co{N(SiMe3)2}2]2: magnetic studies of low-coordinate Co(II) silylamides [Co{N(SiMe3)2}2L] (L = PMe3, pyridine, and THF) and related species that reveal evidence of very large zero-field splittings.	silylamides	170-181	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	163-169
24000351-1	2013	The reaction site of the Co(II) porphyrin created by an amide group and coordinating 1,2-dimethylimidazole at the fifth site activated an O2 molecule, and then hydroxylated the meso-carbon of the ligand.	1,2-dimethylimidazole	85-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-31
24000351-1	2013	The reaction site of the Co(II) porphyrin created by an amide group and coordinating 1,2-dimethylimidazole at the fifth site activated an O2 molecule, and then hydroxylated the meso-carbon of the ligand.	Oxygen	138-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-31
24000351-1	2013	The reaction site of the Co(II) porphyrin created by an amide group and coordinating 1,2-dimethylimidazole at the fifth site activated an O2 molecule, and then hydroxylated the meso-carbon of the ligand.	Carbon	182-188	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-31
24526931-2	2013	One carboxyl-ate group of the anionic ligand chelates a Co(II) cation while another carboxyl-ate group bridges two Co(II) cations, resulting in a polymeric layer parallel to (101).	carboxyl-ate	4-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-62
24041928-7	2013	AEA cytotoxicity was potentiated by FAAH inhibition (2-fold increase, p&lt;0.05) and mitigated by COX-2 or lipoxygenase (LOX) inhibition (5- and 3-fold decrease, respectively; p&lt;0.01).	anandamide	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-103
24041928-10	2013	Overall, these findings demonstrate that AEA induces cytotoxicity against human melanoma cells in the micromolar range of concentrations through a complex mechanism, which involves COX-2 and LOX-derived product synthesis and CB1 activation.	anandamide	41-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	181-186
24155892-2	2013	In this paper, we evaluated, for the first time, the therapeutic benefit of blocking EGRF and/or COX-2 (using gefitinib and NS-398, respectively) in terms of improving the efficacy of the conventional clinical chemotherapeutic drug docetaxel in vitro and vivo.	Gefitinib	110-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
24155892-2	2013	In this paper, we evaluated, for the first time, the therapeutic benefit of blocking EGRF and/or COX-2 (using gefitinib and NS-398, respectively) in terms of improving the efficacy of the conventional clinical chemotherapeutic drug docetaxel in vitro and vivo.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	124-130	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
24155892-2	2013	In this paper, we evaluated, for the first time, the therapeutic benefit of blocking EGRF and/or COX-2 (using gefitinib and NS-398, respectively) in terms of improving the efficacy of the conventional clinical chemotherapeutic drug docetaxel in vitro and vivo.	Docetaxel	232-241	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
24155892-11	2013	Based on previous preclinical research, we conclude that simultaneously blocking EGFR and COX-2 by gefitinib and NS-398 sensitizes advanced PCa cells to docetaxel-induced cytotoxicity.	Gefitinib	99-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-95
24155892-11	2013	Based on previous preclinical research, we conclude that simultaneously blocking EGFR and COX-2 by gefitinib and NS-398 sensitizes advanced PCa cells to docetaxel-induced cytotoxicity.	Docetaxel	153-162	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-95
23897214-0	2013	Cu(I), Co(II) and Fe(II) coordination polymers with pyrazine and benzoate as ligands.	Pyrazines	52-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	7-13
23897214-0	2013	Cu(I), Co(II) and Fe(II) coordination polymers with pyrazine and benzoate as ligands.	Benzoates	65-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	7-13
23897214-2	2013	The isolation and characterization of four coordination polymers obtained by direct reactions of metal ion salts of Cu(II), Co(II) and Fe(II) with pyrazine (pyz) and benzoic/benzoate (Bz) ligands under hydrothermal or hydrothermal microwave conditions are described.	Metals	97-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	124-130
23897214-2	2013	The isolation and characterization of four coordination polymers obtained by direct reactions of metal ion salts of Cu(II), Co(II) and Fe(II) with pyrazine (pyz) and benzoic/benzoate (Bz) ligands under hydrothermal or hydrothermal microwave conditions are described.	Pyrazines	147-155	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	124-130
23897214-2	2013	The isolation and characterization of four coordination polymers obtained by direct reactions of metal ion salts of Cu(II), Co(II) and Fe(II) with pyrazine (pyz) and benzoic/benzoate (Bz) ligands under hydrothermal or hydrothermal microwave conditions are described.	Pyrazines	157-160	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	124-130
23897214-6	2013	These coordination polymers show a spin-canting antiferromagnetism and metamagnetism behaviour for Co(II) and HS   HS/LS   LS spin-crossover phenomena for Fe(II), respectively.	Polymers	19-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-105
23900212-3	2013	The structure of the octanuclear Co(II) complex, 2, is based upon a central Co4 square with the remaining four Co(II) centres at the "wing-tips" of the complex.	2,4-DIAMINO-5-METHYL-6-[(3,4,5-TRIMETHOXY-N-METHYLANILINO)METHYL]PYRIDO[2,3-D]PYRIMIDINE	76-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-39
23900267-3	2013	The presence of acetonitrile molecules in the structure of 1b seems to change the spatial orientation of the terminal metalloligands [NiL] from pseudo-eclipsed in 1a to staggered-like in 1b around the central Co(II).	acetonitrile	16-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	209-215
23939252-0	2013	Voltammetric and spectroscopic characterization of early intermediates in the Co(II)-polypyridyl-catalyzed reduction of water.	Water	120-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-84
24044777-5	2013	The combined experimental and theoretical charge density study identifies the different characters of two types of cobalt ions; more pronounced charge concentration and depletion features in the valence shell charge concentration (VSCC) are found in the Co(III) ion than in the Co(II) ion, and d-orbital populations also show the difference.	Cobalt	115-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	278-284
24044879-0	2013	Tuning transverse anisotropy in Co(III)-Co(II)-Co(III) mixed-valence complex toward slow magnetic relaxation.	co(iii)	32-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-46
24044879-0	2013	Tuning transverse anisotropy in Co(III)-Co(II)-Co(III) mixed-valence complex toward slow magnetic relaxation.	co(iii)	47-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-46
24050728-2	2013	Reaction of [(HPNP)CoCl2] (1) with n-BuLi generated both the deprotonated Co(II) species [(PNP)CoCl] (2) along with the Co(I) complex [(HPNP)CoCl] (3).	(hpnp)cocl2	13-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
24050728-2	2013	Reaction of [(HPNP)CoCl2] (1) with n-BuLi generated both the deprotonated Co(II) species [(PNP)CoCl] (2) along with the Co(I) complex [(HPNP)CoCl] (3).	n-butyllithium	35-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
24050728-2	2013	Reaction of [(HPNP)CoCl2] (1) with n-BuLi generated both the deprotonated Co(II) species [(PNP)CoCl] (2) along with the Co(I) complex [(HPNP)CoCl] (3).	(pnp)cocl	90-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
24050728-2	2013	Reaction of [(HPNP)CoCl2] (1) with n-BuLi generated both the deprotonated Co(II) species [(PNP)CoCl] (2) along with the Co(I) complex [(HPNP)CoCl] (3).	(hpnp)	13-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
24050728-2	2013	Reaction of [(HPNP)CoCl2] (1) with n-BuLi generated both the deprotonated Co(II) species [(PNP)CoCl] (2) along with the Co(I) complex [(HPNP)CoCl] (3).	cocl	19-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
23991708-1	2013	One-electron oxidation or reduction of the paramagnetic dinuclear Co(II) complex dmp2Nin{Co[N(SiMe3)2]}2 (1; dmp2Nin(2-) = bis(2,6-dimethylphenyl)nindigo), by fully reversible chemical or electrochemical methods, generates the radical salts [1(OEt2)](+) and [1](-), respectively.	dmp2nin{co[n(sime3)2]}2	81-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-72
23991708-1	2013	One-electron oxidation or reduction of the paramagnetic dinuclear Co(II) complex dmp2Nin{Co[N(SiMe3)2]}2 (1; dmp2Nin(2-) = bis(2,6-dimethylphenyl)nindigo), by fully reversible chemical or electrochemical methods, generates the radical salts [1(OEt2)](+) and [1](-), respectively.	dmp2nin	81-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-72
23991708-1	2013	One-electron oxidation or reduction of the paramagnetic dinuclear Co(II) complex dmp2Nin{Co[N(SiMe3)2]}2 (1; dmp2Nin(2-) = bis(2,6-dimethylphenyl)nindigo), by fully reversible chemical or electrochemical methods, generates the radical salts [1(OEt2)](+) and [1](-), respectively.	bis(2,6-dimethylphenyl)nindigo	123-153	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-72
23991708-1	2013	One-electron oxidation or reduction of the paramagnetic dinuclear Co(II) complex dmp2Nin{Co[N(SiMe3)2]}2 (1; dmp2Nin(2-) = bis(2,6-dimethylphenyl)nindigo), by fully reversible chemical or electrochemical methods, generates the radical salts [1(OEt2)](+) and [1](-), respectively.	radical salts	227-240	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-72
23991708-1	2013	One-electron oxidation or reduction of the paramagnetic dinuclear Co(II) complex dmp2Nin{Co[N(SiMe3)2]}2 (1; dmp2Nin(2-) = bis(2,6-dimethylphenyl)nindigo), by fully reversible chemical or electrochemical methods, generates the radical salts [1(OEt2)](+) and [1](-), respectively.	(oet2)	243-249	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-72
24526931-1	2013	In the title compound, [Co(C12H12O4)(C5H5N)2] n , the Co(II) cation is coordinated by four O atoms from three 5-tert-butyl-benzene-1,3-di-carboxyl-ate anions and two N atoms from pyridine mol-ecules in a distorted octa-hedral geometry.	[co(c12h12o4)(c5h5n)2] n	23-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-60
24526931-1	2013	In the title compound, [Co(C12H12O4)(C5H5N)2] n , the Co(II) cation is coordinated by four O atoms from three 5-tert-butyl-benzene-1,3-di-carboxyl-ate anions and two N atoms from pyridine mol-ecules in a distorted octa-hedral geometry.	5-tert-butyl-benzene	110-130	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-60
24526931-1	2013	In the title compound, [Co(C12H12O4)(C5H5N)2] n , the Co(II) cation is coordinated by four O atoms from three 5-tert-butyl-benzene-1,3-di-carboxyl-ate anions and two N atoms from pyridine mol-ecules in a distorted octa-hedral geometry.	1,3-di-carboxyl-ate anions	131-157	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-60
24526931-1	2013	In the title compound, [Co(C12H12O4)(C5H5N)2] n , the Co(II) cation is coordinated by four O atoms from three 5-tert-butyl-benzene-1,3-di-carboxyl-ate anions and two N atoms from pyridine mol-ecules in a distorted octa-hedral geometry.	pyridine	179-187	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-60
24526931-1	2013	In the title compound, [Co(C12H12O4)(C5H5N)2] n , the Co(II) cation is coordinated by four O atoms from three 5-tert-butyl-benzene-1,3-di-carboxyl-ate anions and two N atoms from pyridine mol-ecules in a distorted octa-hedral geometry.	octa-hedral	214-225	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-60
24526931-2	2013	One carboxyl-ate group of the anionic ligand chelates a Co(II) cation while another carboxyl-ate group bridges two Co(II) cations, resulting in a polymeric layer parallel to (101).	carboxyl-ate	84-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-121
24047234-3	2013	To address this problem, we report here a new method of constructing this intermediate layer based on the lipophilic redox buffer consisting of the Co(III) and Co(II) complexes of 1,10-phenanthroline ([Co(phen)3](3+/2+)) paired with tetrakis(pentafluorophenyl)borate as counterion.	1,10-phenanthroline	180-199	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	160-166
24047234-3	2013	To address this problem, we report here a new method of constructing this intermediate layer based on the lipophilic redox buffer consisting of the Co(III) and Co(II) complexes of 1,10-phenanthroline ([Co(phen)3](3+/2+)) paired with tetrakis(pentafluorophenyl)borate as counterion.	co(phen)3	202-211	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	160-166
24047234-3	2013	To address this problem, we report here a new method of constructing this intermediate layer based on the lipophilic redox buffer consisting of the Co(III) and Co(II) complexes of 1,10-phenanthroline ([Co(phen)3](3+/2+)) paired with tetrakis(pentafluorophenyl)borate as counterion.	tetrakis(pentafluorophenyl)borate	233-266	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	160-166
24883266-7	2013	NSAIDs and Cox-2 selective inhibitors are anti-inflammatory drugs that decrease prostaglandin and thromboxane production while promoting the synthesis of specialized proresolving mediators.	Prostaglandins	80-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-16
23948065-3	2013	In this study, we found that the isoflavone, biochanin A, inhibited the expression of sUV-induced COX-2, which is a well-characterized sUV-induced enzyme, in both human HaCaT keratinocytes and JB6 P+ mouse skin epidermal cells.	Isoflavones	33-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-103
27121942-1	2013	CG100649, proposed as a dual inhibitor of cyclooxygenase (COX)-2 and carbonic anhydrase (CA)-I/-II, is long-lived in plasma and whole blood.	CG100649	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-64
23536473-0	2013	Necrosis in DU145 prostate cancer spheroids induces COX-2/mPGES-1-derived PGE2 to promote tumor growth and to inhibit T cell activation.	Dinoprostone	74-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-57
23536473-3	2013	Therefore, targeting microsomal PGE synthase 1 (mPGES-1), the downstream enzyme in the COX-2-dependent pathway of PGE2 production might be attractive, although conflicting data regarding a potential tumor-supporting function of mPGES-1 were reported.	Dinoprostone	114-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-92
23536473-7	2013	Pharmacological inhibition of COX-2 and mPGES-1 supported the crucial role of PGE2 for growth of MCTS.	Dinoprostone	78-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-35
23536473-12	2013	In conclusion, necrosis-dependent COX-2 upregulation in MCTS promoted PGE2 -dependent tumor growth and inhibited activated cytotoxic T cells.	Dinoprostone	70-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-39
23838114-11	2013	Piperine significantly decreased the IL-1beta-stimulated gene expression and production of MMP-3, MMP-13, iNOS and COX-2 in human OA chondrocytes.	piperine	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-120
23934131-0	2013	Kaempferol inhibits IL-1beta-induced proliferation of rheumatoid arthritis synovial fibroblasts and the production of COX-2, PGE2 and MMPs.	kaempferol	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-123
23934131-6	2013	Kaempferol inhibited the proliferation of both unstimulated and IL-1beta-stimulated RASFs, as well as the mRNA and protein expression of MMP-1, MMP-3, COX-2 and PGE2 induced by IL-1beta.	kaempferol	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-156
23934131-8	2013	These results indicate that kaempferol inhibits synovial fibroblast proliferation, as well as the production of and MMPs, COX-2 and PGE2, which is involved in articular inflammation and destruction in rheumatoid arthritis (RA).	kaempferol	28-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-127
23953484-9	2013	Acrolein at 5-50 mug/mL increased expression of TNF-alpha and COX-2, as shown by RT-PCR and Western blotting.	Acrolein	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
24156425-0	2013	[COX-2 inhibitor celecoxib can suppress the proliferation of FLT3-ITD positive acute myeloid leukemia cells with prominent down regulation of MEK/MCL-1 expression in vitro].	Celecoxib	17-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	1-6
24308187-5	2013	RESULTS: In comparison with the control group, VAS and RSS-COX 2 scores were significantly lower in the SP 36, GB 39 and non-acupoint groups (P &lt; 0.001, P &lt; 0.05), suggesting an alleviation of the pain severity after EA treatment.	RSS	55-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-64
24308187-5	2013	RESULTS: In comparison with the control group, VAS and RSS-COX 2 scores were significantly lower in the SP 36, GB 39 and non-acupoint groups (P &lt; 0.001, P &lt; 0.05), suggesting an alleviation of the pain severity after EA treatment.	TFF2 protein, human	104-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-64
23884539-0	2013	Employing tripodal carboxylate ligand to construct Co(II) coordination networks modulated by N-donor ligands: syntheses, structures and magnetic properties.	carboxylate	19-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-56
23884539-0	2013	Employing tripodal carboxylate ligand to construct Co(II) coordination networks modulated by N-donor ligands: syntheses, structures and magnetic properties.	Nitrogen	93-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-56
23981089-9	2013	As a result, isomer AEH-based DSSC with quasi-solid-state electrolyte displays the highest eta of 7.10% which remained at 98% of the initial value after continuous light soaking for 1000 h. Promisingly, a eta of 8.66% has been achieved for AEH-based DSSC with liquid electrolyte containing Co(II)/(III) redox couple.	4-(2-aminoethyl)-2-ethylphenol	20-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	290-296
24058438-7	2013	Curcumin also has wide pharmacokinetic effects as an inhibitor of NF-kappaB, eIF-2alpha dephosphorylation, proteasome and COX2.	Curcumin	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-126
24058438-9	2013	Treatment with salubrinal, MG132 and COX2 inhibitor, like curcumin, prevented the replication of RSV and the epithelial responses, and treatment with salubrinal and MG132 enhanced the upregulation of tight junction molecules induced by infection with RSV.	Curcumin	58-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-41
23842534-0	2013	Two novel Co(II) coordination polymers based on 1,4-bis(3-pyridylaminomethyl)benzene as electrocatalysts for oxygen evolution from water.	Polymers	30-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-16
23842534-0	2013	Two novel Co(II) coordination polymers based on 1,4-bis(3-pyridylaminomethyl)benzene as electrocatalysts for oxygen evolution from water.	1,4-bis(3-pyridylaminomethyl)benzene	48-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-16
23842534-0	2013	Two novel Co(II) coordination polymers based on 1,4-bis(3-pyridylaminomethyl)benzene as electrocatalysts for oxygen evolution from water.	Oxygen	109-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-16
23842534-0	2013	Two novel Co(II) coordination polymers based on 1,4-bis(3-pyridylaminomethyl)benzene as electrocatalysts for oxygen evolution from water.	Water	131-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-16
23973710-0	2013	miR-143 decreases COX-2 mRNA stability and expression in pancreatic cancer cells.	mir-143	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-23
23973710-9	2013	COX-2 expression and cellular proliferation in BxPC-3 and HPAF-II inversely correlated with increasing miR-143.	mir-143	103-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
24011132-11	2013	The vasoactive factors: COX-2 and NOS were increased in the ovaries of the OHSS group (P&lt;0.05 and P&lt;0.01) and metformin normalized their expression (P&lt;0.05); suggesting that metformin has a role preventing the increased in vascular permeability caused by the syndrome.	Metformin	183-192	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
24011132-13	2013	These effects of metformin are mediated by inhibiting the increased of the vasoactive molecules: VEGF, COX-2 and partially NOS.	Metformin	17-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-108
24039842-5	2013	Our data showed that cyanidin-3-glucoside reduced cytokine-induced inflammation in intestinal cells, in terms of NO, PGE2 and IL-8 production and of iNOS and COX-2 expressions, at a much lower concentration than 5-aminosalicylic acid, suggesting a higher anti-inflammatory efficiency.	cyanidin-3-o-glucoside	21-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	158-163
23817787-9	2013	The results suggest that the inducible COX-2 can contribute to the endogenous synthesis of PGJ2 derivatives acting as autocrine mediators to simulate adipogenesis during the maturation phase by way of compensation for the suppressed expression of the constitutive COX-1.	9-deoxy-delta-9-prostaglandin D2	91-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-44
23810915-1	2013	BACKGROUND: Studies have examined whether tumor expression of PTGS2 (also known as COX-2), an enzyme inhibited by nonsteroidal anti-inflammatory drugs such as aspirin, is associated with prognosis in patients with colorectal cancer.	Aspirin	159-166	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
22609818-1	2013	BACKGROUND: Cyclooxygenase 1 (COX-1), COX-2, and HO-1 are involved in the process of aspirin"s effect.	Aspirin	85-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-43
23899748-2	2013	This study assesses the chronic effects of celecoxib (selective COX-2 inhibitor) versus diclofenac (non-selective NSAID) therapy on arterial dysfunction in patients with rheumatoid arthritis (RA).	Celecoxib	43-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-69
24204414-2	2013	A regio- and diastereoselective Co(II)-catalyzed hydration of the olefin and a transannular epoxide opening were used as the key reactions.	Alkenes	66-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-37
24204414-2	2013	A regio- and diastereoselective Co(II)-catalyzed hydration of the olefin and a transannular epoxide opening were used as the key reactions.	Epoxy Compounds	92-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-37
23832857-1	2013	Chain gang: A chain-based 2D Co(II) coordination polymer was prepared by hydrothermal reaction of Co(NO3)2 6 H2O, H2L and bpa in the presence of sodium hydroxide.	cobaltous nitrate	98-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34
23832857-1	2013	Chain gang: A chain-based 2D Co(II) coordination polymer was prepared by hydrothermal reaction of Co(NO3)2 6 H2O, H2L and bpa in the presence of sodium hydroxide.	h2l	114-117	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34
23832857-1	2013	Chain gang: A chain-based 2D Co(II) coordination polymer was prepared by hydrothermal reaction of Co(NO3)2 6 H2O, H2L and bpa in the presence of sodium hydroxide.	bisphenol A	122-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34
23832857-1	2013	Chain gang: A chain-based 2D Co(II) coordination polymer was prepared by hydrothermal reaction of Co(NO3)2 6 H2O, H2L and bpa in the presence of sodium hydroxide.	Sodium Hydroxide	145-161	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34
23834707-0	2013	Antiproliferative diarylpyrazole derivatives as dual inhibitors of the ERK pathway and COX-2.	diarylpyrazole	18-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-92
24883266-7	2013	NSAIDs and Cox-2 selective inhibitors are anti-inflammatory drugs that decrease prostaglandin and thromboxane production while promoting the synthesis of specialized proresolving mediators.	Thromboxanes	98-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-16
23001685-3	2013	The aim of this study was to evaluate the effects of a selective cyclooxygenase (COX)-2 inhibitor, celecoxib, on synovial fluids and tissues in severely osteoarthritic knees.	Celecoxib	99-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-87
23764826-6	2013	The calculated redox tuning of Co(I)H interactions on the reduction potential of Co(II)/Co(I) couple (60-800 mV vs standard hydrogen electrode (SHE)), irrespective of the beta-axial ligand considered, is significantly higher than the biological redox gap between the reduction potential of Co(II)/Co(I) couple and that of the biological reducing agents (50 mV vs SHE).	NAD	31-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-87
23764826-6	2013	The calculated redox tuning of Co(I)H interactions on the reduction potential of Co(II)/Co(I) couple (60-800 mV vs standard hydrogen electrode (SHE)), irrespective of the beta-axial ligand considered, is significantly higher than the biological redox gap between the reduction potential of Co(II)/Co(I) couple and that of the biological reducing agents (50 mV vs SHE).	NAD	31-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	290-296
23764826-6	2013	The calculated redox tuning of Co(I)H interactions on the reduction potential of Co(II)/Co(I) couple (60-800 mV vs standard hydrogen electrode (SHE)), irrespective of the beta-axial ligand considered, is significantly higher than the biological redox gap between the reduction potential of Co(II)/Co(I) couple and that of the biological reducing agents (50 mV vs SHE).	Hydrogen	124-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-87
23764826-7	2013	The analysis of existing crystallographic data for the reactivation conformation of MetH enzyme (1K7Y (@3.0 A); 1K98 (@3.8 A) and 3IVA (@2.7 A)) indicates that the Y1139 residue and the beta-axial H2O ligand in the MetH-bound Co(II)Cbx complex are equidistant from the Co(II) ion (Y1139Co(II)=3.97 A; H2OCo(II)=3.96 A).	Water	197-200	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	269-275
23764826-7	2013	The analysis of existing crystallographic data for the reactivation conformation of MetH enzyme (1K7Y (@3.0 A); 1K98 (@3.8 A) and 3IVA (@2.7 A)) indicates that the Y1139 residue and the beta-axial H2O ligand in the MetH-bound Co(II)Cbx complex are equidistant from the Co(II) ion (Y1139Co(II)=3.97 A; H2OCo(II)=3.96 A).	Cobalt(2+)	226-232	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	269-275
23764826-7	2013	The analysis of existing crystallographic data for the reactivation conformation of MetH enzyme (1K7Y (@3.0 A); 1K98 (@3.8 A) and 3IVA (@2.7 A)) indicates that the Y1139 residue and the beta-axial H2O ligand in the MetH-bound Co(II)Cbx complex are equidistant from the Co(II) ion (Y1139Co(II)=3.97 A; H2OCo(II)=3.96 A).	Carboxin	232-235	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	269-275
24084455-11	2013	NM inhibited COX-2 expression in a dose-dependent fashion and had no effect on COX-1 expression.	nm	0-2	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
23679681-8	2013	Melatonin also reduced the expression of COX-2 and inhibited AKT activation in HepG2 and SMMC-7721 cells.	Melatonin	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-46
23931237-0	2013	Re: Cox-2 inhibition enhances the activity of sunitinib in human renal cell carcinoma xenografts.	Sunitinib	46-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
23643743-5	2013	CUS produced an increase in COX-2 protein expression and enhanced Meth-induced monoaminergic depletions in the striatum and hippocampus.	cus	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
23617728-8	2013	In fact, inhibition of COX-2 with NS398 is associated with a 2-9-fold upregulation of KAI-1/CD82 RNA.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	34-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-28
24352312-1	2013	AIMS: Etoricoxib is a second-generation selective COX-2 inhibitor.	Etoricoxib	6-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-55
23092161-6	2013	MAG-DHA decreased NFkappaB activation leading to a reduction in COX-2 expression level in both A549 cells and lung adenocarcinoma tissues.	docosahexaenoic acid monoacylglyceride	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-69
23092161-9	2013	Lastly, MAG-DHA markedly decreased COX-2 and enhanced PTEN protein expression in tumor tissue sections.	docosahexaenoic acid monoacylglyceride	8-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40
23679681-9	2013	Inhibition of COX-2 activity with the selective inhibitor, NS398, and inhibition of AKT activation using the PI3K inhibitor, LY294002, in tumor cells confirmed that melatonin-induced apoptosis was COX-2/PI3K/AKT-dependent, suggesting that the COX-2/PI3K/AKT pathway plays a role in melatonin inhibition of IAPs.	Melatonin	165-174	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
23679681-9	2013	Inhibition of COX-2 activity with the selective inhibitor, NS398, and inhibition of AKT activation using the PI3K inhibitor, LY294002, in tumor cells confirmed that melatonin-induced apoptosis was COX-2/PI3K/AKT-dependent, suggesting that the COX-2/PI3K/AKT pathway plays a role in melatonin inhibition of IAPs.	Melatonin	165-174	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	197-202
23679681-9	2013	Inhibition of COX-2 activity with the selective inhibitor, NS398, and inhibition of AKT activation using the PI3K inhibitor, LY294002, in tumor cells confirmed that melatonin-induced apoptosis was COX-2/PI3K/AKT-dependent, suggesting that the COX-2/PI3K/AKT pathway plays a role in melatonin inhibition of IAPs.	Melatonin	165-174	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	197-202
23679681-10	2013	Taken together, these results suggest that melatonin overcomes apoptosis resistance by the suppressing survivin and XIAP via the COX-2/PI3K/AKT pathway in HCC cells.	Melatonin	43-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-134
23932824-6	2013	Furthermore, MAG-DPA treatments decreased NFkappaB activation leading to a reduction in Bcl-2, CyclinD1, c-myc, COX-2, MMP9 and VEGF expression levels in tumor tissue sections.	1-O-docosapentaenoylglycerol	13-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-117
23643631-0	2013	Melamine activates NFkappaB/COX-2/PGE2 pathway and increases NADPH oxidase-dependent ROS production in macrophages and human embryonic kidney cells.	melamine	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
23643631-6	2013	In addition, melamine significantly increased COX-2 expression and prostaglandin E2 (PGE2) production.	melamine	13-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
23643631-9	2013	In conclusion, our findings suggest melamine increased inflammation and oxidative stress via activation of NF-kappaB/COX-2 and NOX/ROS pathway, and first revealed the critical role of NOX in melamine-induced ROS production, suggesting the potential of NOX inhibitor against melamine toxicity.	melamine	36-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-122
23643631-9	2013	In conclusion, our findings suggest melamine increased inflammation and oxidative stress via activation of NF-kappaB/COX-2 and NOX/ROS pathway, and first revealed the critical role of NOX in melamine-induced ROS production, suggesting the potential of NOX inhibitor against melamine toxicity.	melamine	191-199	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-122
23643631-9	2013	In conclusion, our findings suggest melamine increased inflammation and oxidative stress via activation of NF-kappaB/COX-2 and NOX/ROS pathway, and first revealed the critical role of NOX in melamine-induced ROS production, suggesting the potential of NOX inhibitor against melamine toxicity.	melamine	191-199	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-122
24027449-0	2013	Co(II) and Cd(II) complexes derived from heterocyclic Schiff-Bases: synthesis, structural characterisation, and biological activity.	Schiff Bases	54-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
23831835-1	2013	Terpyridine ligands with ter- and quater-phenyl substituents at the 4" position provide bis(ligand)Co(II) complexes showing very different magnetic properties to those of their analogues with long-chain aliphatic substituents, with no evidence of "re-entrant" behavior involving multiple high- and low-spin species.	2,2':6',2''-Terpyridine	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-104
23831835-3	2013	Consideration of available structural and magnetic data for these and other Co(II) complexes of functionalised terpyridines and terpyridine itself provides evidence that spin crossover behaviour may be regulated by face-to-face contacts of the pyridyl units of the head groups.	terpyridines	111-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-82
23831835-3	2013	Consideration of available structural and magnetic data for these and other Co(II) complexes of functionalised terpyridines and terpyridine itself provides evidence that spin crossover behaviour may be regulated by face-to-face contacts of the pyridyl units of the head groups.	2,2':6',2''-Terpyridine	111-122	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-82
23847198-5	2013	We demonstrate that IVIg expands Tregs via induction of cyclooxygenase (COX)-2-dependent prostaglandin E2 (PGE2) in human DCs.	Dinoprostone	89-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-78
23847198-5	2013	We demonstrate that IVIg expands Tregs via induction of cyclooxygenase (COX)-2-dependent prostaglandin E2 (PGE2) in human DCs.	Dinoprostone	107-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-78
23847198-7	2013	Inhibition of PGE2 synthesis by COX-2 inhibitors prevented IVIg-mediated Treg expansion in vitro and significantly diminished IVIg-mediated Treg expansion in vivo and protection from disease in experimental autoimmune encephalomyelitis model.	Dinoprostone	14-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-37
24427001-1	2013	The title mol-ecule, [CoCl2(C5H5N)2(H2O)2], has -1 symmetry with the Co(II) ion situated on an inversion centre.	cocl2(c5h5n)2(h2o)2	22-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-75
23872401-8	2013	Moreover, it was found that treatment of prostaglandin E2 (PGE2), which was the main down-stream metabolite of COX-2, increased the expression of PLGF.	Dinoprostone	41-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	111-116
23872401-8	2013	Moreover, it was found that treatment of prostaglandin E2 (PGE2), which was the main down-stream metabolite of COX-2, increased the expression of PLGF.	Dinoprostone	59-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	111-116
23806103-10	2013	Films of poly-[M(vbpy)3](PF6)2 with M = Co(II) or Cu(II) were also prepared and evaluated as electrocatalysts for H2O oxidation.	poly-[m(vbpy)3](pf6)2	9-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-46
23806103-11	2013	Films containing Co(II) reached current densities of 6.0 mA/cm(2) at +1.8 V vs NHE in H2O.	Water	86-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-23
23973990-2	2013	Cyclooxygenase (COX)-2, the rate-limiting enzyme in the synthesis of prostaglandins, is over-expressed by several tumours.	Prostaglandins	69-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-22
23783365-7	2013	X-ray photoelectron spectroscopy (XPS) data displayed the valence state of the cobalt element as Co(ii) or Co(iii) oxide species.	Cobalt	79-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-103
24027449-3	2013	Complexes of the general formula [M(L)2]Cl2 (where M = Co(II) or Cd(II), L = L1 or L2) have been obtained from the reaction of the corresponding metal chloride with the ligands.	[m(l)2]cl2	33-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-61
23848966-5	2013	The crystal structure of the mixed-anion complex salt 2 consists of trinuclear [Co3(mu3-MoO4)2(mu2-F)2] units self-assembling in Co(II)-undulating chains (Co   Co 3.0709(15) and 3.3596(7) A), which are cross-linked by tr2pr in layers.	Salts	49-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-135
23807426-0	2013	Unusual composition dependence of magnetic relaxation for Co(II)(1-x)Ni(II)(x) chain-based metal-organic frameworks.	Nickel(2+)	69-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-64
23807426-0	2013	Unusual composition dependence of magnetic relaxation for Co(II)(1-x)Ni(II)(x) chain-based metal-organic frameworks.	Metals	91-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-64
23807426-1	2013	A series of isomorphous 3D Co(II)(1-x)Ni(II)(x) MOFs based on ferromagnetic chains show SCM-type slow relaxation and the Co-rich system can exhibit a higher blocking temperature than both Co(II) and Ni(II) parent materials.	Nickel(2+)	38-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-33
23807426-1	2013	A series of isomorphous 3D Co(II)(1-x)Ni(II)(x) MOFs based on ferromagnetic chains show SCM-type slow relaxation and the Co-rich system can exhibit a higher blocking temperature than both Co(II) and Ni(II) parent materials.	Nickel(2+)	199-205	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-33
23859016-0	2013	Enhanced 5-fluorouracil cytotoxicity in high COX-2 expressing hepatocellular carcinoma cells by wogonin via the PI3K/Akt pathway.	Fluorouracil	9-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-50
23907872-1	2013	The title compound, Rb2[Co(H2O)6](C8H5O4)4 4H2O, consists of nearly regular octahedral [Co(H2O)6]2+ cations with the CoII cations on the inversion centre (special position 2a), Rb+ cations, hydrogen phthalate (Hpht-) anions and disordered water molecules.	co(h2o)6	24-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-121
23664858-8	2013	IL-1beta-induced COX-2 mRNA and protein expression decreased significantly following co-treatment with pirfenidone.	pirfenidone	103-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22
23788486-5	2013	Upon changing the I(-) /I3 (-) electrolyte to the Co(II) /Co(III) redox couple, the cell gave rise to a significantly improved conversion efficiency of 10.02% with the multifunctional HC-A, which is one of the highest values reported for DSSCs with a cobalt-based electrolyte.	Cobalt	251-257	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-56
23788486-5	2013	Upon changing the I(-) /I3 (-) electrolyte to the Co(II) /Co(III) redox couple, the cell gave rise to a significantly improved conversion efficiency of 10.02% with the multifunctional HC-A, which is one of the highest values reported for DSSCs with a cobalt-based electrolyte.	Electrolytes	31-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-56
23664858-11	2013	Our results suggest that pirfenidone attenuates the IL-1beta-induced PGE2/COX-2 production in TAO orbital fibroblasts, which is related with suppression of the NF-kappaB activation.	pirfenidone	25-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
23664858-0	2013	Pirfenidone attenuates IL-1beta-induced COX-2 and PGE2 production in orbital fibroblasts through suppression of NF-kappaB activity.	pirfenidone	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
23689555-7	2013	Post-treatment with PPs also more efficiently than pretreatment prevented UV-induced overexpression of IL-1 beta, IL-6 and COX2 mRNAs.	pps	20-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-127
23664858-1	2013	The aim of this study was to determine the effect of pirfenidone on interleukin (IL)-1beta-induced cyclooxygenase (COX)-2 and prostaglandin (PG)E2 expression in orbital fibroblasts from patients with thyroid-associated ophthalmopathy (TAO).	pirfenidone	53-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-121
23664858-4	2013	The effect of pirfenidone on IL-1beta-induced COX-2 expression in orbital fibroblasts from patients with TAO was evaluated by reverse transcription-polymerase chain reaction (PCR) and quantitative real-time PCR analyses, and verified by Western blot.	pirfenidone	14-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
23734008-12	2013	In small resistance arteries of essential hypertensive patients, COX-2 is overexpressed and reduces nitric oxide availability.	Nitric Oxide	100-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-70
23791636-7	2013	By immunoprecipitation (IP) assays we also demonstrated an increased association between Group V sPLA2 and COX-2 in retinas exposed to iron overload.	Iron	135-139	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-112
23685470-1	2013	The interaction of Co(III) and Co(II) cobalamin (Cbl) and cobinamide (Cbi) with thiocyanate was examined with UV-vis and EPR spectra.	Vitamin B 12	49-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-37
23775426-5	2013	Cu(I) binds to both the apopeptides and the Co(II)-substituted peptides, and the stoichiometry of Cu(I) binding is dependent on the number of cysteine thiols at the metal binding site.	cuprous ion	0-5	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-49
23775426-5	2013	Cu(I) binds to both the apopeptides and the Co(II)-substituted peptides, and the stoichiometry of Cu(I) binding is dependent on the number of cysteine thiols at the metal binding site.	cysteine thiols	142-157	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-49
23817417-6	2013	Importantly, treatment with celecoxib, a COX-2 inhibitor, resulted in significantly lower PGE2 and IL-17A, but not IFN-gamma, production.	Celecoxib	28-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-46
23817417-6	2013	Importantly, treatment with celecoxib, a COX-2 inhibitor, resulted in significantly lower PGE2 and IL-17A, but not IFN-gamma, production.	Dinoprostone	90-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-46
23817417-8	2013	These findings show a critical role for the COX-2/PGE2 pathway in driving Th17-mediated synovial inflammation in an IL-23- and monocyte-independent manner.	Dinoprostone	50-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-49
23685470-1	2013	The interaction of Co(III) and Co(II) cobalamin (Cbl) and cobinamide (Cbi) with thiocyanate was examined with UV-vis and EPR spectra.	cobinamide	58-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-37
23685470-1	2013	The interaction of Co(III) and Co(II) cobalamin (Cbl) and cobinamide (Cbi) with thiocyanate was examined with UV-vis and EPR spectra.	cobinamide	70-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-37
23685470-1	2013	The interaction of Co(III) and Co(II) cobalamin (Cbl) and cobinamide (Cbi) with thiocyanate was examined with UV-vis and EPR spectra.	thiocyanate	80-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-37
23685470-3	2013	Performed calculations suggest the prevalence of isothiocyanato isomers over thiocyanato complexes on both Co(III) and Co(II) centers.	isothiocyanato	49-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-125
23685470-3	2013	Performed calculations suggest the prevalence of isothiocyanato isomers over thiocyanato complexes on both Co(III) and Co(II) centers.	thiocyanato	52-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-125
23685470-5	2013	DFT data maintain the possibility of hexacoordinated Co(II) complexes with thiocyanate in which one of extra-ligands is weakly coordinated.	thiocyanate	75-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-59
23778325-0	2013	Impact of genetic polymorphisms on adenoma recurrence and toxicity in a COX2 inhibitor (celecoxib) trial: results from a pilot study.	Celecoxib	88-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-76
24101387-8	2013	NF-kappaB and MAPK cascades-activated transcription factor activator protein 1 (AP-1) and CREB-binding protein (CBP/p300) lead to expression of cytosolic phospholipase A2 (cPLA2), cyclooxygenase-2 (COX-2) and membrane-bound prostaglandin E synthase 1 (mPGES-1), and thus to increased release of arachidonic acid and production of prostaglandins, particularly prostaglandin E2 (PGE2).	Arachidonic Acid	295-311	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	198-203
24101387-8	2013	NF-kappaB and MAPK cascades-activated transcription factor activator protein 1 (AP-1) and CREB-binding protein (CBP/p300) lead to expression of cytosolic phospholipase A2 (cPLA2), cyclooxygenase-2 (COX-2) and membrane-bound prostaglandin E synthase 1 (mPGES-1), and thus to increased release of arachidonic acid and production of prostaglandins, particularly prostaglandin E2 (PGE2).	Prostaglandins	330-344	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	198-203
24101387-8	2013	NF-kappaB and MAPK cascades-activated transcription factor activator protein 1 (AP-1) and CREB-binding protein (CBP/p300) lead to expression of cytosolic phospholipase A2 (cPLA2), cyclooxygenase-2 (COX-2) and membrane-bound prostaglandin E synthase 1 (mPGES-1), and thus to increased release of arachidonic acid and production of prostaglandins, particularly prostaglandin E2 (PGE2).	Dinoprostone	359-375	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	198-203
24101387-8	2013	NF-kappaB and MAPK cascades-activated transcription factor activator protein 1 (AP-1) and CREB-binding protein (CBP/p300) lead to expression of cytosolic phospholipase A2 (cPLA2), cyclooxygenase-2 (COX-2) and membrane-bound prostaglandin E synthase 1 (mPGES-1), and thus to increased release of arachidonic acid and production of prostaglandins, particularly prostaglandin E2 (PGE2).	Dinoprostone	377-381	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	198-203
23880112-9	2013	The ability of sunitinib to affect NF-kappaB, COX2 and NOS2 expression was determined by western blot.	Sunitinib	15-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-50
23880112-12	2013	Exposure of neurons to sunitinib also induced an increase in the expression of NF-kappaB, COX2 and NOS2.	Sunitinib	23-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-94
23880112-14	2013	Treatment of cell cultures with both sunitinib and NF-kappaB inhibitors mitigated the increase in COX2 and NOS2 caused by sunitinib.	Sunitinib	37-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-102
23880112-14	2013	Treatment of cell cultures with both sunitinib and NF-kappaB inhibitors mitigated the increase in COX2 and NOS2 caused by sunitinib.	Sunitinib	122-131	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-102
23880112-16	2013	Also, the inflammatory proteins COX2 and NOS2 are upregulated by sunitinib in an NF-kappaB-dependent manner.	Sunitinib	65-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-36
23786234-2	2013	For COX-2, the stereochemistry and relative abundance of generated products is influenced by Ser530 acetylation following aspirin treatment.	Aspirin	122-129	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
23786234-3	2013	The molecular bases of the high degree of stereospecificity which characterizes COX-2-catalyzed oxygenations are not yet completely understood, nor are the reasons behind the aspirin-induced shift in lipid mediator production.	Aspirin	175-182	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-85
23786234-5	2013	This hypothesis is supported by a computational model which accurately reproduces experimental oxygenation patterns on both native and aspirin-inhibited COX-2.	Aspirin	135-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	153-158
23454738-1	2013	In this work, based on electronic spinning resonance and chemiluminescence (CL) measurements, it is found that the reaction kinetics of Co(II)-triggered Fenton-like reaction is much faster than those of other transition metal ions, which facilitates the observation of the strong CL signals from Co(II).	Metals	220-225	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	136-141
23454738-1	2013	In this work, based on electronic spinning resonance and chemiluminescence (CL) measurements, it is found that the reaction kinetics of Co(II)-triggered Fenton-like reaction is much faster than those of other transition metal ions, which facilitates the observation of the strong CL signals from Co(II).	Metals	220-225	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	136-142
23454738-2	2013	Utilizing the polymer-surfactant complexes (i.e., necklace model) to act as a novel CL microenvironment, a highly selective CL sensing system for the detection of Co(II) has been successfully fabricated based on the CL resonance energy transfer between the Fenton-like reaction and necklace model microenvironment-modulated carbon dots.	Carbon	324-330	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	163-169
23869238-0	2013	Berberine Targets AP-2/hTERT, NF-kappaB/COX-2, HIF-1alpha/VEGF and Cytochrome-c/Caspase Signaling to Suppress Human Cancer Cell Growth.	Berberine	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
23732516-2	2013	Compound 1 was formed by the cleavage of Co-Cl bonds, the reduction of Co(II) to Co(I) and by the coordination of a toluene molecule.	Cobalt	0-2	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-77
23695032-0	2013	Tuning affinity and reversibility for O2 binding in dinuclear Co(II) complexes.	Oxygen	38-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-68
23695032-6	2013	Using density functional theory calculations, we conclude that the Co(II) atoms of the deoxy complexes coordinate solvent molecules as auxiliary ligands and that a conformation change of the ligand is involved in the reversible O2 binding process.	Oxygen	228-230	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-72
23676951-1	2013	One pot reaction of hydrated chloride salts of Fe(II) and Co(II) with stoichiometric amounts of 2,2"-bipyrimidine (bpym) in a methanol-acetonitrile mixture afforded the corresponding 1D homonuclear coordination polymers, [mu-(bpym)MCl2]n. Crystal structures of both complexes are isomorphous in the highly symmetric orthorhombic space group Fddd.	Chlorides	29-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-64
23676951-1	2013	One pot reaction of hydrated chloride salts of Fe(II) and Co(II) with stoichiometric amounts of 2,2"-bipyrimidine (bpym) in a methanol-acetonitrile mixture afforded the corresponding 1D homonuclear coordination polymers, [mu-(bpym)MCl2]n. Crystal structures of both complexes are isomorphous in the highly symmetric orthorhombic space group Fddd.	2,2'-Bipyrimidine	96-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-64
23676951-1	2013	One pot reaction of hydrated chloride salts of Fe(II) and Co(II) with stoichiometric amounts of 2,2"-bipyrimidine (bpym) in a methanol-acetonitrile mixture afforded the corresponding 1D homonuclear coordination polymers, [mu-(bpym)MCl2]n. Crystal structures of both complexes are isomorphous in the highly symmetric orthorhombic space group Fddd.	2,2'-Bipyrimidine	115-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-64
23676951-1	2013	One pot reaction of hydrated chloride salts of Fe(II) and Co(II) with stoichiometric amounts of 2,2"-bipyrimidine (bpym) in a methanol-acetonitrile mixture afforded the corresponding 1D homonuclear coordination polymers, [mu-(bpym)MCl2]n. Crystal structures of both complexes are isomorphous in the highly symmetric orthorhombic space group Fddd.	Methanol	126-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-64
23676951-1	2013	One pot reaction of hydrated chloride salts of Fe(II) and Co(II) with stoichiometric amounts of 2,2"-bipyrimidine (bpym) in a methanol-acetonitrile mixture afforded the corresponding 1D homonuclear coordination polymers, [mu-(bpym)MCl2]n. Crystal structures of both complexes are isomorphous in the highly symmetric orthorhombic space group Fddd.	acetonitrile	135-147	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-64
23874405-5	2013	In contrast, the non-selective COX inhibitor aspirin and the COX-2 specific inhibitor NS-398 had no effect on MYC expression and glucose metabolism.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	86-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-66
23668350-2	2013	Human COX-1 and COX-2 isozymes have been modeled using in silico tools and relative efficacies of terpenoids as their inhibitors have been investigated by docking.	Terpenes	98-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-21
24109269-1	2013	In the title salt, [Co(C7H9NO)2(H2O)2]Cl2, the Co(II) cation, located on an inversion center, is N,O-chelated by two hy-droxy-ethyl-pyridine ligands and coordinated by two water mol-ecules in a distorted O4N2 octa-hedral geometry.	Salts	13-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-53
24109269-1	2013	In the title salt, [Co(C7H9NO)2(H2O)2]Cl2, the Co(II) cation, located on an inversion center, is N,O-chelated by two hy-droxy-ethyl-pyridine ligands and coordinated by two water mol-ecules in a distorted O4N2 octa-hedral geometry.	[co(c7h9no)2(h2o)2]cl2	19-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-53
24109269-1	2013	In the title salt, [Co(C7H9NO)2(H2O)2]Cl2, the Co(II) cation, located on an inversion center, is N,O-chelated by two hy-droxy-ethyl-pyridine ligands and coordinated by two water mol-ecules in a distorted O4N2 octa-hedral geometry.	ethyl-pyridine	126-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-53
24109269-1	2013	In the title salt, [Co(C7H9NO)2(H2O)2]Cl2, the Co(II) cation, located on an inversion center, is N,O-chelated by two hy-droxy-ethyl-pyridine ligands and coordinated by two water mol-ecules in a distorted O4N2 octa-hedral geometry.	Water	172-177	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-53
23682075-1	2013	COX-2 and 5-lipoxygenase (5-LO) use arachidonic acid for the synthesis of eicosanoids that have been implicated in carcinogenesis and cardiovascular disease.	Arachidonic Acid	36-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
23682075-1	2013	COX-2 and 5-lipoxygenase (5-LO) use arachidonic acid for the synthesis of eicosanoids that have been implicated in carcinogenesis and cardiovascular disease.	Eicosanoids	74-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
23682075-2	2013	The ability of celecoxib, a selective COX-2 inhibitor, to redirect arachidonic acid into the 5-LO pathway can potentially reduce its efficacy as a chemopreventive agent and increase the risk of cardiovascular complications.	Celecoxib	15-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-43
23682075-2	2013	The ability of celecoxib, a selective COX-2 inhibitor, to redirect arachidonic acid into the 5-LO pathway can potentially reduce its efficacy as a chemopreventive agent and increase the risk of cardiovascular complications.	Arachidonic Acid	67-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-43
23682075-9	2013	In conclusion, zileuton was an effective inhibitor of 5-LO activity resulting in marked suppression of urinary LTE4 levels and possible redirection of arachidonic acid into the COX-2 pathway in a subset of subjects.	zileuton	15-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	177-182
23682075-10	2013	Combining celecoxib and zileuton was associated with inhibition of both the COX-2 and 5-LO pathways manifested as reduced levels of urinary PGE-M and LTE4.	Celecoxib	10-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-87
23682075-10	2013	Combining celecoxib and zileuton was associated with inhibition of both the COX-2 and 5-LO pathways manifested as reduced levels of urinary PGE-M and LTE4.	zileuton	24-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-87
23682075-10	2013	Combining celecoxib and zileuton was associated with inhibition of both the COX-2 and 5-LO pathways manifested as reduced levels of urinary PGE-M and LTE4.	Prostaglandins E	140-143	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-87
23398566-7	2013	Following co-incubation with n-butyrate and lipopolysaccharide, key enzymes of the eicosanoid pathway, like PTGS2 (COX-2), TXS, ALOX5, LTA4H and LTC4S, were significantly up-regulated compared with stimulation with lipopolysaccharide alone.	Butyrates	29-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-120
23398566-7	2013	Following co-incubation with n-butyrate and lipopolysaccharide, key enzymes of the eicosanoid pathway, like PTGS2 (COX-2), TXS, ALOX5, LTA4H and LTC4S, were significantly up-regulated compared with stimulation with lipopolysaccharide alone.	Eicosanoids	83-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-120
23812217-9	2013	In vitro treatment with 4-NQO altered expression of RARbeta2, p-ERK1/2, and COX2 in human esophageal cancer cells.	4-Nitroquinoline-1-oxide	24-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-80
23812217-13	2013	CONCLUSION: 4-NQO-induced cancer in oral cavity and esophagus of mice not only pathologically and morphologically mimicked human oral and esophageal cancer, but also shared some molecular alterations (e.g. aberrant expression of Rarb2, p-ERK1/2, and Cox2).	4-Nitroquinoline-1-oxide	12-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	250-254
23777336-2	2013	Magnetic susceptibility measurements and X-ray diffraction (XRD) analysis reveal a central low-spin octahedral Co(2+) ion with both ligands in the neutral radical form (L( )) forming a linear L( )   Co(II)   L( ) arrangement.	Cobalt(2+)	111-117	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	199-205
23331485-11	2013	CONCLUSION: The COX inhibitors indomethacin and celecoxib reduce the expression of inflammatory factors, such as COX-2 and IL-6, in FLS from the TMJ via suppression of PGE2 production.	Indomethacin	31-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-118
23331485-11	2013	CONCLUSION: The COX inhibitors indomethacin and celecoxib reduce the expression of inflammatory factors, such as COX-2 and IL-6, in FLS from the TMJ via suppression of PGE2 production.	Celecoxib	48-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-118
23475986-6	2013	In placenta and foetal membranes, all treatments significantly reduced LPS-stimulated release and gene expression of pro-inflammatory cytokines IL-6 and IL-8; placenta decreased cyclooxygenase (COX-2) mRNA expression, subsequent release of prostaglandins PGE2 and PGF2alpha and expression and activity of matrix-degrading enzyme matrix metalloproteinase (MMP)-9.	Prostaglandins	240-254	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	194-199
23475986-6	2013	In placenta and foetal membranes, all treatments significantly reduced LPS-stimulated release and gene expression of pro-inflammatory cytokines IL-6 and IL-8; placenta decreased cyclooxygenase (COX-2) mRNA expression, subsequent release of prostaglandins PGE2 and PGF2alpha and expression and activity of matrix-degrading enzyme matrix metalloproteinase (MMP)-9.	Dinoprostone	255-259	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	194-199
23475986-6	2013	In placenta and foetal membranes, all treatments significantly reduced LPS-stimulated release and gene expression of pro-inflammatory cytokines IL-6 and IL-8; placenta decreased cyclooxygenase (COX-2) mRNA expression, subsequent release of prostaglandins PGE2 and PGF2alpha and expression and activity of matrix-degrading enzyme matrix metalloproteinase (MMP)-9.	Dinoprost	264-273	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	194-199
23624211-1	2013	The binuclear complexes of 2-(3-amino-2-hydrazono-4-oxothiazolidin-5-yl) acetic acid ligand (HL) with Fe(III), Co(II), Ni(II), Cu(II) and Zn(II) ions were prepared and their stoichiometry was determined by elemental analysis.	2-(3-amino-2-hydrazono-4-oxothiazolidin-5-yl) acetic acid	27-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	111-117
23624211-3	2013	According to the elemental analysis data, the complexes were found to have the formulae [Fe2L(H2O)8]Cl5 and [M2L(H2O)8]Cl3 (M=Co(II), Ni(II), Cu(II) and Zn(II)).	[m2l(h2o)8]cl3	108-122	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-132
23796953-2	2013	Among the COX-2 downstream signaling pathways, the prostaglandin E2 (PGE2) receptor EP2 subtype (PTGER2) is emerging as a crucial mediator of many physiological and pathological events.	Dinoprostone	51-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
24833939-11	2013	COX-2 expression was observed after the addition of the demethylating agent 5-Aza-dC and was enhanced by PDBu.	Decitabine	76-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
23637134-9	2013	COX-2 activity was elevated at 4 and 24 h after RE (P &lt; 0.05, PRE: 51 +- 7, 4 h: 100 +- 19, 24 h: 98 +- 14 nmol PGH2 g total protein(-1) min(-1)).	Prostaglandin H2	115-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
24046862-4	2013	Using the NS398 specific inhibitor of COX-2, we provide evidence that reactive oxygen species by-produced by the COX-2 enzymatic activity are negligible in front of the total senescence-associated oxidative stress.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	10-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-43
24046862-4	2013	Using the NS398 specific inhibitor of COX-2, we provide evidence that reactive oxygen species by-produced by the COX-2 enzymatic activity are negligible in front of the total senescence-associated oxidative stress.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	10-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-118
24046862-4	2013	Using the NS398 specific inhibitor of COX-2, we provide evidence that reactive oxygen species by-produced by the COX-2 enzymatic activity are negligible in front of the total senescence-associated oxidative stress.	Reactive Oxygen Species	70-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-43
24046862-4	2013	Using the NS398 specific inhibitor of COX-2, we provide evidence that reactive oxygen species by-produced by the COX-2 enzymatic activity are negligible in front of the total senescence-associated oxidative stress.	Reactive Oxygen Species	70-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-118
24046862-11	2013	Taken together, these results suggest that COX-2 contributes to the establishment and maintenance of senescence of normal human fibroblasts via an independent-ROS and a dependent-PGE2/EPs intracrine pathway.	Reactive Oxygen Species	159-162	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
24046862-11	2013	Taken together, these results suggest that COX-2 contributes to the establishment and maintenance of senescence of normal human fibroblasts via an independent-ROS and a dependent-PGE2/EPs intracrine pathway.	Dinoprostone	179-183	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
24046862-11	2013	Taken together, these results suggest that COX-2 contributes to the establishment and maintenance of senescence of normal human fibroblasts via an independent-ROS and a dependent-PGE2/EPs intracrine pathway.	exophthalmos producing substance	184-187	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
23668350-3	2013	The docking analyses of 10 selected terpenoids along with drugs revealed that all of the terpenoids were more potent inhibitors of COX-1 rather than COX-2 with the oleanolic acid as the most potent inhibitor of COX in general (binding energy [-18.68Kcal/mol and -18.25Kcal/mol] and estimated Ki [5.57x10(-8)microM and 11.4x10(-8)microM] for COX-1 and COX-2, respectively) and beta-carotene as most selective inhibitor of COX-1.	Oleanolic Acid	164-178	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	149-154
23668350-4	2013	Furthermore, ibuprofen and aspirin were found to be preferential inhibitor of COX-1 and COX-2, respectively.	Ibuprofen	13-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-93
23668350-4	2013	Furthermore, ibuprofen and aspirin were found to be preferential inhibitor of COX-1 and COX-2, respectively.	Aspirin	27-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-93
23680778-5	2013	Inflammation is an essential step in the fracture healing process in which prostaglandin production by COX-2 is involved.	Prostaglandins	75-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-108
23398566-10	2013	Our results suggest that among many other mediators of eicosanoid signalling n-butyrate massively induces PGE(2) production by increasing the expression of PTGS2 (COX-2) in monocytes following TLR4 and TLR2 activation and induces secretion of LTB(4) and thromboxane B(2).	Eicosanoids	55-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	163-168
23398566-10	2013	Our results suggest that among many other mediators of eicosanoid signalling n-butyrate massively induces PGE(2) production by increasing the expression of PTGS2 (COX-2) in monocytes following TLR4 and TLR2 activation and induces secretion of LTB(4) and thromboxane B(2).	Butyrates	77-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	163-168
23398566-10	2013	Our results suggest that among many other mediators of eicosanoid signalling n-butyrate massively induces PGE(2) production by increasing the expression of PTGS2 (COX-2) in monocytes following TLR4 and TLR2 activation and induces secretion of LTB(4) and thromboxane B(2).	Prostaglandins E	106-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	163-168
23398566-10	2013	Our results suggest that among many other mediators of eicosanoid signalling n-butyrate massively induces PGE(2) production by increasing the expression of PTGS2 (COX-2) in monocytes following TLR4 and TLR2 activation and induces secretion of LTB(4) and thromboxane B(2).	thromboxane b	254-267	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	163-168
23580446-4	2013	Platelet-induced COX-2-dependent prostaglandin E2 (PGE2) synthesis in HT29 cells was involved in the downregulation of p21(WAF1/CIP1) and the upregulation of cyclinB1 since these effects were prevented by rofecoxib (a selective COX-2 inhibitor) and rescued by exogenous PGE2.	Dinoprostone	33-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22
23580446-4	2013	Platelet-induced COX-2-dependent prostaglandin E2 (PGE2) synthesis in HT29 cells was involved in the downregulation of p21(WAF1/CIP1) and the upregulation of cyclinB1 since these effects were prevented by rofecoxib (a selective COX-2 inhibitor) and rescued by exogenous PGE2.	Dinoprostone	33-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	228-233
23580446-4	2013	Platelet-induced COX-2-dependent prostaglandin E2 (PGE2) synthesis in HT29 cells was involved in the downregulation of p21(WAF1/CIP1) and the upregulation of cyclinB1 since these effects were prevented by rofecoxib (a selective COX-2 inhibitor) and rescued by exogenous PGE2.	Dinoprostone	51-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22
23580446-4	2013	Platelet-induced COX-2-dependent prostaglandin E2 (PGE2) synthesis in HT29 cells was involved in the downregulation of p21(WAF1/CIP1) and the upregulation of cyclinB1 since these effects were prevented by rofecoxib (a selective COX-2 inhibitor) and rescued by exogenous PGE2.	Dinoprostone	51-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	228-233
23580446-4	2013	Platelet-induced COX-2-dependent prostaglandin E2 (PGE2) synthesis in HT29 cells was involved in the downregulation of p21(WAF1/CIP1) and the upregulation of cyclinB1 since these effects were prevented by rofecoxib (a selective COX-2 inhibitor) and rescued by exogenous PGE2.	rofecoxib	205-214	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22
23580446-4	2013	Platelet-induced COX-2-dependent prostaglandin E2 (PGE2) synthesis in HT29 cells was involved in the downregulation of p21(WAF1/CIP1) and the upregulation of cyclinB1 since these effects were prevented by rofecoxib (a selective COX-2 inhibitor) and rescued by exogenous PGE2.	Dinoprostone	270-274	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22
23645839-7	2013	In addition, treatment with nimesulide, a COX-2 selective inhibitor, dramatically suppresses xenograft tumor formation and inhibits in vivo progression of human leukemia cells.	nimesulide	28-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47
23692429-1	2013	Electrocatalytic water oxidation occurs at fluoride-doped tin oxide (FTO) electrodes that have been surface-modified by addition of Co(II).	Water	17-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-138
23692429-1	2013	Electrocatalytic water oxidation occurs at fluoride-doped tin oxide (FTO) electrodes that have been surface-modified by addition of Co(II).	Fluorides	43-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-138
23692429-1	2013	Electrocatalytic water oxidation occurs at fluoride-doped tin oxide (FTO) electrodes that have been surface-modified by addition of Co(II).	stannic oxide	58-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-138
23692429-1	2013	Electrocatalytic water oxidation occurs at fluoride-doped tin oxide (FTO) electrodes that have been surface-modified by addition of Co(II).	L 685458	69-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-138
23692429-3	2013	On the basis of cyclic voltammetry measurements, surface-bound Co(II) undergoes a pH-dependent 1e(-)/1H(+) oxidation to Co(III), which is followed by pH-dependent catalytic water oxidation.	Hydrogen	101-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-69
23692429-3	2013	On the basis of cyclic voltammetry measurements, surface-bound Co(II) undergoes a pH-dependent 1e(-)/1H(+) oxidation to Co(III), which is followed by pH-dependent catalytic water oxidation.	Water	173-178	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-69
24046556-1	2013	The title compound, [Co(C3H7NO)(H2O)5]SO4 C3H7NO, contains five aqua ligands, a Co(II) atom, a sulfate ion and both a coordinating and a non-coordinating di-methyl-formamide (DMF) mol-ecule.	[co(c3h7no)(h2o)5]so4 c3h7no	20-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-86
24046556-4	2013	The Co(II) atom has distorted octa-hedral coordination geometry, being ligated by five aqua ligands and the O atom of the DMF ligand.	octa-hedral	30-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
24046556-4	2013	The Co(II) atom has distorted octa-hedral coordination geometry, being ligated by five aqua ligands and the O atom of the DMF ligand.	Dimethylformamide	122-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
23532394-6	2013	DFT calculations (BP86/TZVP) on model compounds of BzCbl and PhVnCbl show that the Co-C bond dissociation energy for homolysis to Co(II) and an organic radical in the former is 8 kcal mol(-1) lower than in the latter.	bzcbl	51-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	130-136
23532394-6	2013	DFT calculations (BP86/TZVP) on model compounds of BzCbl and PhVnCbl show that the Co-C bond dissociation energy for homolysis to Co(II) and an organic radical in the former is 8 kcal mol(-1) lower than in the latter.	phvncbl	61-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	130-136
23532394-6	2013	DFT calculations (BP86/TZVP) on model compounds of BzCbl and PhVnCbl show that the Co-C bond dissociation energy for homolysis to Co(II) and an organic radical in the former is 8 kcal mol(-1) lower than in the latter.	co-c	83-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	130-136
32260983-9	2013	The expression levels of IL-6 and COX-2 were reduced dramatically when increasing the proportion of Mg80-OLA20 from 0 to 50 wt%.	mg80-ola20	100-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-39
23692474-4	2013	Here, the magnetic blocking in the series of isostructural 3d-4f complexes Co(II)-Ln(III)-Co(II), Ln = Gd, Tb, and Dy, is analyzed using an originally developed ab initio based approach for the investigation of blocking barriers.	Terbium	107-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-96
23692474-6	2013	It turns out that the highly efficient magnetic blockage in the Co-Gd-Co complex results from a concomitant effect of unexpectedly large unquenched orbital momentum on Co(II) ions (ca.	co-gd-co	64-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	168-174
23731702-3	2013	Celecoxib (CXB), a selective COX-2 inhibitor, suppresses VEGF gene expression by targeting the VEGF promoter responsible for its inhibitory effect.	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34
23731702-3	2013	Celecoxib (CXB), a selective COX-2 inhibitor, suppresses VEGF gene expression by targeting the VEGF promoter responsible for its inhibitory effect.	Celecoxib	11-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34
23731702-8	2013	At the molecular level, TAM-CXB suppresses VHL-mediated HIF-1alpha activation, responsible for expression of COX-2, MMP-2 and VEGF.	tam-cxb	24-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-114
24189757-2	2013	Adverse effects of NSAIDs are specifically related to their underlying mechanisms of action.The most plausible mechanism underlying the cardiovascular risk of NSAIDs has been identified in the profound inhibition of COX-2-dependent PGI2 in the presence of incomplete and intermittent inhibition of platelet COX-1.	Epoprostenol	232-236	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	216-221
23715071-7	2013	Ketorolac most effectively inhibited COX-1 enzymes; COX-2 enzymes were most effectively reduced by amfenac.	amfenac	99-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-57
23670888-5	2013	Compound 2b had a better selectivity ratio (COX-1/COX-2) compared to that of celecoxib and can be used as a novel template for the design of selective COX-2 inhibitors.	Celecoxib	77-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-156
23485680-10	2013	Further, 4-ME significantly ameliorated the upregulated non-enzymatic inflammatory markers like TNF-alpha, IL-1beta, IL-6, COX-2 and PGE2.	4-methylesculetin	9-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-128
23558156-8	2013	Western blot analyses showed an inhibitory effect of L137 on the iNOS and COX-2 expression, mediated by a modulation of redox-sensitive nuclear transcriptional factor (NF)-kappaB, known to control a wide array of genes involved in inflammation.	1-phenyl-6,7-dihydroxy-isochroman	53-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
23636051-4	2013	Considering the importance of the proinflammatory COX-2-derived prostaglandin E2 (PGE2) in inflammation and cancer, Morris and colleagues found that urinary PGE-M is positively associated with obesity, smoking, and lung metastases in patients with breast cancer (4).	Dinoprostone	64-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-55
23636051-4	2013	Considering the importance of the proinflammatory COX-2-derived prostaglandin E2 (PGE2) in inflammation and cancer, Morris and colleagues found that urinary PGE-M is positively associated with obesity, smoking, and lung metastases in patients with breast cancer (4).	Dinoprostone	82-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-55
23636051-4	2013	Considering the importance of the proinflammatory COX-2-derived prostaglandin E2 (PGE2) in inflammation and cancer, Morris and colleagues found that urinary PGE-M is positively associated with obesity, smoking, and lung metastases in patients with breast cancer (4).	Prostaglandins E	82-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-55
23505121-1	2013	Cyclooxygenase (COX) enzyme synthesizes prostaglandins (PGs) from arachidonic acid and exists as two major isozymes, COX-1 and COX-2.	Prostaglandins	40-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	127-132
23505121-1	2013	Cyclooxygenase (COX) enzyme synthesizes prostaglandins (PGs) from arachidonic acid and exists as two major isozymes, COX-1 and COX-2.	Prostaglandins	56-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	127-132
23505121-1	2013	Cyclooxygenase (COX) enzyme synthesizes prostaglandins (PGs) from arachidonic acid and exists as two major isozymes, COX-1 and COX-2.	Arachidonic Acid	66-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	127-132
23307337-0	2013	Taurine enhances antinociception produced by a COX-2 inhibitor in an inflammatory pain model.	Taurine	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
23307337-2	2013	In this work, we interfere pharmacologically with those states that produce peripheral and central sensitisation after an acute inflammatory process, inhibiting at the periphery the COX-2 with celecoxib and using taurine (glycine A receptor agonist) for central pain relief.	Celecoxib	193-202	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	182-187
23719833-4	2013	Despite the similarities to NSAIDs, the mode of action of paracetamol has been uncertain, but it is now generally accepted that it inhibits COX-1 and COX-2 through metabolism by the peroxidase function of these isoenzymes.	Acetaminophen	58-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	150-155
23719833-5	2013	This results in inhibition of phenoxyl radical formation from a critical tyrosine residue essential for the cyclooxygenase activity of COX-1 and COX-2 and prostaglandin (PG) synthesis.	phenoxy radical	30-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-150
23719833-14	2013	As is the case with the NSAIDs, including the selective COX-2 inhibitors, the analgesic effects of paracetamol are reduced by inhibitors of many endogenous neurotransmitter systems including serotonergic, opioid and cannabinoid systems.	Cannabinoids	216-227	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-61
23719833-5	2013	This results in inhibition of phenoxyl radical formation from a critical tyrosine residue essential for the cyclooxygenase activity of COX-1 and COX-2 and prostaglandin (PG) synthesis.	Tyrosine	73-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-150
23719833-5	2013	This results in inhibition of phenoxyl radical formation from a critical tyrosine residue essential for the cyclooxygenase activity of COX-1 and COX-2 and prostaglandin (PG) synthesis.	Prostaglandins	155-168	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-150
23719833-8	2013	Paracetamol often appears to have COX-2 selectivity.	Acetaminophen	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-39
23719833-9	2013	The apparent COX-2 selectivity of action of paracetamol is shown by its poor anti-platelet activity and good gastrointestinal tolerance.	Acetaminophen	44-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
23719833-14	2013	As is the case with the NSAIDs, including the selective COX-2 inhibitors, the analgesic effects of paracetamol are reduced by inhibitors of many endogenous neurotransmitter systems including serotonergic, opioid and cannabinoid systems.	Acetaminophen	99-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-61
23588209-10	2013	In addition, TES inhibited the expression of cyclooxygenase (COX)-2 and the phosphorylation of c-Jun NH2-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK) MAPKs, suggesting that it inhibits the secretion of the pro-inflammatory cytokines IL-6 and IL-8 and COX-2 expression by blocking MAPK phosphorylation.	tectroside	13-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-67
23588209-10	2013	In addition, TES inhibited the expression of cyclooxygenase (COX)-2 and the phosphorylation of c-Jun NH2-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK) MAPKs, suggesting that it inhibits the secretion of the pro-inflammatory cytokines IL-6 and IL-8 and COX-2 expression by blocking MAPK phosphorylation.	tectroside	13-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	276-281
25337538-5	2013	Human papillomavirus, a necessary cause of cervical cancer, induces COX-2 expression via E5, E6 and E7 oncoproteins, which leads to prostaglandin E2 increase and the loss of E-cadherin, promotes cell proliferation and production of vascular endothelial growth factor.	Dinoprostone	132-148	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-73
23645882-6	2013	Blocking PGE2 synthesis by NS398, a COX2 inhibitor, abrogated the enhancement of p19 expression both in vitro and in vivo.	Dinoprostone	9-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-40
23645882-6	2013	Blocking PGE2 synthesis by NS398, a COX2 inhibitor, abrogated the enhancement of p19 expression both in vitro and in vivo.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	27-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-40
23737956-7	2013	UA also significantly inhibited colon cancer cell COX-2 expression and PGE2 production.	ursolic acid	0-2	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-55
23737956-8	2013	Pretreatment with a COX-2 inhibitor (celecoxib) abrogated the UA-induced cell proliferation.	Celecoxib	37-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-25
23737956-8	2013	Pretreatment with a COX-2 inhibitor (celecoxib) abrogated the UA-induced cell proliferation.	ursolic acid	62-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-25
23737956-12	2013	These results indicate that UA inhibits cell proliferation and induces apoptosis in colon cancer cells through simultaneous modulation of the multiple signaling pathways such as MMP9/CDH1, Akt/ERK, COX-2/PGE2, p300/NF-kappaB/CREB2, and cytochrome c/caspase pathways.	ursolic acid	28-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	198-203
23634668-5	2013	In an effort to seek Co(II)-independent inhibitors, a novel structural class containing a 2-(pyridin-2-yl)quinazoline core has been discovered.	2-(pyridin-2-yl)quinazoline	90-117	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-27
23508380-2	2013	Aminolysis of [Co(NHC){N(SiMe3)2}Cl] with N-H acidic compounds such as substituted amidines and anilines leads to novel Co(II) complexes with monodentate N-heterocyclic carbene ligation.	n(sime3)2}cl	23-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-126
23508380-2	2013	Aminolysis of [Co(NHC){N(SiMe3)2}Cl] with N-H acidic compounds such as substituted amidines and anilines leads to novel Co(II) complexes with monodentate N-heterocyclic carbene ligation.	Amidines	83-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-126
23508380-2	2013	Aminolysis of [Co(NHC){N(SiMe3)2}Cl] with N-H acidic compounds such as substituted amidines and anilines leads to novel Co(II) complexes with monodentate N-heterocyclic carbene ligation.	Aniline Compounds	96-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-126
23508380-2	2013	Aminolysis of [Co(NHC){N(SiMe3)2}Cl] with N-H acidic compounds such as substituted amidines and anilines leads to novel Co(II) complexes with monodentate N-heterocyclic carbene ligation.	carbene	169-176	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-126
23508380-3	2013	Attempts to prepare Co(II) dibenzyl complexes with bulky IPr coligands led to metal reduction to Co(I) and aromatic C-H activation and C-C coupling between the benzyl groups.	Metals	78-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-26
23706161-4	2013	RESULTS: Treatment of breast cancer cell lines with lapatinib and OSU-03012 (a small molecule derivative of the Cox-2 inhibitor celecoxib) induced synergistic cytotoxic/cytostatic effects.	Lapatinib	52-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-117
23706161-4	2013	RESULTS: Treatment of breast cancer cell lines with lapatinib and OSU-03012 (a small molecule derivative of the Cox-2 inhibitor celecoxib) induced synergistic cytotoxic/cytostatic effects.	OSU 03012	66-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-117
23706161-4	2013	RESULTS: Treatment of breast cancer cell lines with lapatinib and OSU-03012 (a small molecule derivative of the Cox-2 inhibitor celecoxib) induced synergistic cytotoxic/cytostatic effects.	Celecoxib	128-137	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-117
23717544-1	2013	BACKGROUND: 15-Hydroxyprostaglandin dehydrogenase (15-PGDH) is a metabolic antagonist of COX-2, catalyzing the degradation of inflammation mediator prostaglandin E2 (PGE2) and other prostanoids.	Dinoprostone	148-164	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-94
23508268-3	2013	Structural analysis shows that in 1 the capped-octahedral environment around the Co(II) centers is highly distorted with rather long bonds between the metal and donor atoms.	Metals	151-156	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-87
23508268-4	2013	The tbta ligand binds to the Co(II) centers through the three triazole nitrogen donor atoms in a facial form, with the Co-N(amine) distance of 2.494(2) A acting as a capping bond to the octahedron.	titanocene bis(trichloroacetate)	4-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-35
23508268-4	2013	The tbta ligand binds to the Co(II) centers through the three triazole nitrogen donor atoms in a facial form, with the Co-N(amine) distance of 2.494(2) A acting as a capping bond to the octahedron.	Triazoles	62-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-35
23508268-4	2013	The tbta ligand binds to the Co(II) centers through the three triazole nitrogen donor atoms in a facial form, with the Co-N(amine) distance of 2.494(2) A acting as a capping bond to the octahedron.	Nitrogen	71-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-35
23508268-4	2013	The tbta ligand binds to the Co(II) centers through the three triazole nitrogen donor atoms in a facial form, with the Co-N(amine) distance of 2.494(2) A acting as a capping bond to the octahedron.	co-n	119-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-35
23508268-4	2013	The tbta ligand binds to the Co(II) centers through the three triazole nitrogen donor atoms in a facial form, with the Co-N(amine) distance of 2.494(2) A acting as a capping bond to the octahedron.	Amines	124-129	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-35
23508268-4	2013	The tbta ligand binds to the Co(II) centers through the three triazole nitrogen donor atoms in a facial form, with the Co-N(amine) distance of 2.494(2) A acting as a capping bond to the octahedron.	octahedron	186-196	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-35
23508268-5	2013	In the crystal an unusual observation of one acetonitrile molecule statistically occupying the coordination sites at both Co(II) centers is made.	acetonitrile	45-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-128
23717544-1	2013	BACKGROUND: 15-Hydroxyprostaglandin dehydrogenase (15-PGDH) is a metabolic antagonist of COX-2, catalyzing the degradation of inflammation mediator prostaglandin E2 (PGE2) and other prostanoids.	Dinoprostone	166-170	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-94
23717544-1	2013	BACKGROUND: 15-Hydroxyprostaglandin dehydrogenase (15-PGDH) is a metabolic antagonist of COX-2, catalyzing the degradation of inflammation mediator prostaglandin E2 (PGE2) and other prostanoids.	Prostaglandins	182-193	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-94
23646986-4	2013	The Co(II)-Ln(III) and Ni(II)-Ln(III) complexes are crystallized in an isomorphous monoclinic space group P2(1)/c, where the Co(II) or Ni(II) ion at the high-spin state has an octahedral coordination environment with N2O2 donor atoms of 3-MeOsaltn at the equatorial sites, and one oxygen atom of the bridged acetato and a methanol oxygen atom at the two axial sites.	Oxygen	281-287	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
23646986-4	2013	The Co(II)-Ln(III) and Ni(II)-Ln(III) complexes are crystallized in an isomorphous monoclinic space group P2(1)/c, where the Co(II) or Ni(II) ion at the high-spin state has an octahedral coordination environment with N2O2 donor atoms of 3-MeOsaltn at the equatorial sites, and one oxygen atom of the bridged acetato and a methanol oxygen atom at the two axial sites.	Nickel(2+)	23-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-131
23646986-4	2013	The Co(II)-Ln(III) and Ni(II)-Ln(III) complexes are crystallized in an isomorphous monoclinic space group P2(1)/c, where the Co(II) or Ni(II) ion at the high-spin state has an octahedral coordination environment with N2O2 donor atoms of 3-MeOsaltn at the equatorial sites, and one oxygen atom of the bridged acetato and a methanol oxygen atom at the two axial sites.	Nickel(2+)	135-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
23646986-4	2013	The Co(II)-Ln(III) and Ni(II)-Ln(III) complexes are crystallized in an isomorphous monoclinic space group P2(1)/c, where the Co(II) or Ni(II) ion at the high-spin state has an octahedral coordination environment with N2O2 donor atoms of 3-MeOsaltn at the equatorial sites, and one oxygen atom of the bridged acetato and a methanol oxygen atom at the two axial sites.	dioxohydrazine	217-221	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
23646986-4	2013	The Co(II)-Ln(III) and Ni(II)-Ln(III) complexes are crystallized in an isomorphous monoclinic space group P2(1)/c, where the Co(II) or Ni(II) ion at the high-spin state has an octahedral coordination environment with N2O2 donor atoms of 3-MeOsaltn at the equatorial sites, and one oxygen atom of the bridged acetato and a methanol oxygen atom at the two axial sites.	3-meosaltn	237-247	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
23646986-4	2013	The Co(II)-Ln(III) and Ni(II)-Ln(III) complexes are crystallized in an isomorphous monoclinic space group P2(1)/c, where the Co(II) or Ni(II) ion at the high-spin state has an octahedral coordination environment with N2O2 donor atoms of 3-MeOsaltn at the equatorial sites, and one oxygen atom of the bridged acetato and a methanol oxygen atom at the two axial sites.	acetato	308-315	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
23646986-4	2013	The Co(II)-Ln(III) and Ni(II)-Ln(III) complexes are crystallized in an isomorphous monoclinic space group P2(1)/c, where the Co(II) or Ni(II) ion at the high-spin state has an octahedral coordination environment with N2O2 donor atoms of 3-MeOsaltn at the equatorial sites, and one oxygen atom of the bridged acetato and a methanol oxygen atom at the two axial sites.	Methanol	322-330	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
23794966-3	2013	The Co(II) ion is octahedrally coordinated by three phosphonoformato ligands (one bi- and the other monodentate) and by two O atoms from the bridging aqua ligands.	phosphonoformato	52-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
23646986-4	2013	The Co(II)-Ln(III) and Ni(II)-Ln(III) complexes are crystallized in an isomorphous monoclinic space group P2(1)/c, where the Co(II) or Ni(II) ion at the high-spin state has an octahedral coordination environment with N2O2 donor atoms of 3-MeOsaltn at the equatorial sites, and one oxygen atom of the bridged acetato and a methanol oxygen atom at the two axial sites.	Oxygen	331-337	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
23794966-5	2013	The complex mol-ecules are linked to give a three-dimensional structure by phosphono-formate ligands bridging Co(II) atoms and water mol-ecules establishing cobalt-sodium bridges.	Foscarnet	75-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-116
23646986-11	2013	Alternating current (ac) susceptibility measurements demonstrated that the Ni(II)-Tb(III) and Co(II)-Tb(III) complexes showed out-of-phase signal with frequency-dependence and the Ni(II)-Dy(III) and Co(II)-Dy(III) complexes showed small frequency-dependence.	Nickel(2+)	75-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	199-205
23794966-5	2013	The complex mol-ecules are linked to give a three-dimensional structure by phosphono-formate ligands bridging Co(II) atoms and water mol-ecules establishing cobalt-sodium bridges.	cobalt-sodium	157-170	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-116
23646986-11	2013	Alternating current (ac) susceptibility measurements demonstrated that the Ni(II)-Tb(III) and Co(II)-Tb(III) complexes showed out-of-phase signal with frequency-dependence and the Ni(II)-Dy(III) and Co(II)-Dy(III) complexes showed small frequency-dependence.	Terbium	82-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	199-205
23646986-11	2013	Alternating current (ac) susceptibility measurements demonstrated that the Ni(II)-Tb(III) and Co(II)-Tb(III) complexes showed out-of-phase signal with frequency-dependence and the Ni(II)-Dy(III) and Co(II)-Dy(III) complexes showed small frequency-dependence.	tb(iii)	82-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	199-205
23646986-11	2013	Alternating current (ac) susceptibility measurements demonstrated that the Ni(II)-Tb(III) and Co(II)-Tb(III) complexes showed out-of-phase signal with frequency-dependence and the Ni(II)-Dy(III) and Co(II)-Dy(III) complexes showed small frequency-dependence.	Nickel(2+)	180-186	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-100
23646986-12	2013	The energy barrier for the spin flipping was estimated from the Arrhenius plot to be 14.9(6) and 17.0(4) K for the Ni(II)-Tb(III) and Co(II)-Tb(III) complexes, respectively, under a dc bias field of 1000 Oe.	Terbium	141-143	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-140
23631353-2	2013	Previous studies mainly focused on the development of highly efficient catalysts, while rare reports concerned the mechanistic understanding of metal valence change, associated with the formation of inactive Co(II)-Salen complex.	Metals	144-149	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	208-214
23631353-3	2013	Herein, we report the mechanistic aspects of catalyst deactivation regarding the transformation of Co(III) to Co(II) derivative in the HKR of racemic epoxides catalyzed by SalenCo(III)OAc complexes with an appended 1,5,7-triazabicyclo[4.4.0]dec-5-ene on the ligand framework by means of electrospray ionization mass spectrometry (ESI-MS).	Epoxy Compounds	150-158	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-116
23631353-3	2013	Herein, we report the mechanistic aspects of catalyst deactivation regarding the transformation of Co(III) to Co(II) derivative in the HKR of racemic epoxides catalyzed by SalenCo(III)OAc complexes with an appended 1,5,7-triazabicyclo[4.4.0]dec-5-ene on the ligand framework by means of electrospray ionization mass spectrometry (ESI-MS).	triazabicyclodecene	215-250	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-116
23631353-4	2013	Continuous determination of transient cationic species in ESI-MS positive mode in conjunction with UV-vis spectroscopic studies at various time points provides evidence that a certain amount of SalenCo(III)OAc molecules were reduced to the corresponding Co(II) derivatives in the HKR of racemic propylene oxide or styrene oxide.	propylene oxide	295-310	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	254-260
23631353-4	2013	Continuous determination of transient cationic species in ESI-MS positive mode in conjunction with UV-vis spectroscopic studies at various time points provides evidence that a certain amount of SalenCo(III)OAc molecules were reduced to the corresponding Co(II) derivatives in the HKR of racemic propylene oxide or styrene oxide.	styrene oxide	314-327	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	254-260
23631353-5	2013	To be accompanied by the reduction of Co(III) to Co(II), the resultant diols were oxidized to alpha-hydroxy ketones.	alpha-hydroxy ketones	94-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-55
23471155-8	2013	Whereas in complex 3, H2L(-) ligand links two Co(II) centers via one oxygen and one sulphur atoms.	h2l	22-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-52
23471155-8	2013	Whereas in complex 3, H2L(-) ligand links two Co(II) centers via one oxygen and one sulphur atoms.	Oxygen	69-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-52
23583394-9	2013	GM reduced expression of anti-apoptotic protein Bcl-2 and induced expression of Bax and cleaved caspase 3; these effects and GM-induced expression of COX-2 and iNOS were also attenuated by MSP.	Gentamicins	125-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	150-155
23454135-1	2013	Selective COX-2 inhibitors (COXib) belonging to the class of diaryl heterocycles (e.g., celecoxib, rofecoxib, etc.	Celecoxib	88-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
23454135-1	2013	Selective COX-2 inhibitors (COXib) belonging to the class of diaryl heterocycles (e.g., celecoxib, rofecoxib, etc.	rofecoxib	99-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
23454135-10	2013	These data suggest that compounds VA441 and VA428, along with their role in inhibiting COX-2 and inflammation, could have a possible therapeutic (topical and systemic) use against skin proliferative disorders, such as psoriasis.	2-methyl-5-(4-methylsulphonyl)phenyl-1-phenyl-3-(2-n-propyloxyethyl)-1H-pyrrole	34-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-92
23454135-10	2013	These data suggest that compounds VA441 and VA428, along with their role in inhibiting COX-2 and inflammation, could have a possible therapeutic (topical and systemic) use against skin proliferative disorders, such as psoriasis.	VA428	44-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-92
23687559-0	2013	The 2"-Trifluoromethyl Analogue of Indomethacin Is a Potent and Selective COX-2 Inhibitor.	Indomethacin	35-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
23687559-1	2013	Indomethacin is a potent, time-dependent, nonselective inhibitor of the cyclooxygenase enzymes (COX-1 and COX-2).	Indomethacin	0-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-111
23687559-3	2013	Here, we report that substitution of the 2"-methyl group of indomethacin with trifluoromethyl produces CF3-indomethacin, a tight-binding inhibitor with kinetic properties similar to those of indomethacin and unexpected COX-2 selectivity (IC50 mCOX-2 = 267 nM; IC50 oCOX-1 &gt; 100 muM).	Indomethacin	60-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	219-224
23687559-3	2013	Here, we report that substitution of the 2"-methyl group of indomethacin with trifluoromethyl produces CF3-indomethacin, a tight-binding inhibitor with kinetic properties similar to those of indomethacin and unexpected COX-2 selectivity (IC50 mCOX-2 = 267 nM; IC50 oCOX-1 &gt; 100 muM).	cf3-indomethacin	103-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	219-224
23687559-3	2013	Here, we report that substitution of the 2"-methyl group of indomethacin with trifluoromethyl produces CF3-indomethacin, a tight-binding inhibitor with kinetic properties similar to those of indomethacin and unexpected COX-2 selectivity (IC50 mCOX-2 = 267 nM; IC50 oCOX-1 &gt; 100 muM).	Indomethacin	107-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	219-224
23687559-4	2013	Studies with site-directed mutants reveal that COX-2 selectivity results from insertion of the CF3 group into a small hydrophobic pocket formed by Ala-527, Val-349, Ser-530, and Leu-531 and projection of the methoxy group toward a side pocket bordered by Val-523.	Alanine	147-150	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
23687559-4	2013	Studies with site-directed mutants reveal that COX-2 selectivity results from insertion of the CF3 group into a small hydrophobic pocket formed by Ala-527, Val-349, Ser-530, and Leu-531 and projection of the methoxy group toward a side pocket bordered by Val-523.	Valine	156-159	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
23687559-4	2013	Studies with site-directed mutants reveal that COX-2 selectivity results from insertion of the CF3 group into a small hydrophobic pocket formed by Ala-527, Val-349, Ser-530, and Leu-531 and projection of the methoxy group toward a side pocket bordered by Val-523.	Serine	165-168	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
23687559-4	2013	Studies with site-directed mutants reveal that COX-2 selectivity results from insertion of the CF3 group into a small hydrophobic pocket formed by Ala-527, Val-349, Ser-530, and Leu-531 and projection of the methoxy group toward a side pocket bordered by Val-523.	Leucine	178-181	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
23687559-4	2013	Studies with site-directed mutants reveal that COX-2 selectivity results from insertion of the CF3 group into a small hydrophobic pocket formed by Ala-527, Val-349, Ser-530, and Leu-531 and projection of the methoxy group toward a side pocket bordered by Val-523.	Valine	255-258	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
23687559-5	2013	CF3-indomethacin inhibited COX-2 activity in human head and neck squamous cell carcinoma cells and exhibited in vivo anti-inflammatory activity in the carrageenan-induced rat paw edema model with similar potency to that of indomethacin.	cf3-indomethacin	0-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-32
23687559-5	2013	CF3-indomethacin inhibited COX-2 activity in human head and neck squamous cell carcinoma cells and exhibited in vivo anti-inflammatory activity in the carrageenan-induced rat paw edema model with similar potency to that of indomethacin.	Indomethacin	4-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-32
23031659-8	2013	COX-2 inhibitors were well tolerated in the majority of the patients [nimesulide: 91.9%; meloxicam: 90.2%; rofecoxib: 94.9%; and celecoxib: 94.9%)].	nimesulide	70-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
23535906-1	2013	The dinucleating ligand L (1,3-bis[bis(pyridin-2-ylmethyl)amino]propan-2-ol) combined with metal ions efficiently cleaves DNA when M : L is 1 : 1 (M = Co(II) or Fe(III)) at pH 5.5-7.0, with free L being more active at acidic pH than when bound to Zn(II), Cu(II) or Ni(II) at neutral pH.	1,3-bis(bis(pyridin-2-ylmethyl)amino)propan-2-ol	27-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-157
23535906-1	2013	The dinucleating ligand L (1,3-bis[bis(pyridin-2-ylmethyl)amino]propan-2-ol) combined with metal ions efficiently cleaves DNA when M : L is 1 : 1 (M = Co(II) or Fe(III)) at pH 5.5-7.0, with free L being more active at acidic pH than when bound to Zn(II), Cu(II) or Ni(II) at neutral pH.	Metals	91-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-157
23658755-9	2013	However, co-pretreatment with tunicamycin and Pae decreased the expression of COX-2 and levels of activation of Akt as well as increasing the levels of CHOP in HCC cells.	Tunicamycin	30-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-83
23658755-10	2013	CONCLUSIONS/SIGNIFICANCE: Our results demonstrate that Pae reverses ER stress-induced resistance to doxorubicin in human hepatocellular carcinoma cells by targeting COX-2 mediated inactivation of PI3K/AKT/CHOP.	paeonol	55-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	165-170
23031659-8	2013	COX-2 inhibitors were well tolerated in the majority of the patients [nimesulide: 91.9%; meloxicam: 90.2%; rofecoxib: 94.9%; and celecoxib: 94.9%)].	Meloxicam	89-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
23031659-8	2013	COX-2 inhibitors were well tolerated in the majority of the patients [nimesulide: 91.9%; meloxicam: 90.2%; rofecoxib: 94.9%; and celecoxib: 94.9%)].	rofecoxib	107-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
23031659-8	2013	COX-2 inhibitors were well tolerated in the majority of the patients [nimesulide: 91.9%; meloxicam: 90.2%; rofecoxib: 94.9%; and celecoxib: 94.9%)].	Celecoxib	129-138	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
23031659-11	2013	CONCLUSION: Our results suggest to follow the traditional DPT method to introduce COX-2 inhibitors for finding safe alternatives in all patients with cross-reactive NSAID hypersensitivity before prescription as uncertainty of any predictive factor for a positive response continues.	dpt	58-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
23528298-0	2013	Molecular design, synthesis and biological evaluation of cyclic imides bearing benzenesulfonamide fragment as potential COX-2 inhibitors.	cyclic imides	57-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-125
23517721-2	2013	The di-tert-butyl phenol class of compounds has been found to inhibit both COX-2 and 5-LOX enzymes with proven effectiveness in arresting tumor growth.	di-tert-butyl phenol	4-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-86
23528298-0	2013	Molecular design, synthesis and biological evaluation of cyclic imides bearing benzenesulfonamide fragment as potential COX-2 inhibitors.	benzenesulfonamide	79-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-125
23528298-2	2013	A group of cyclic imides (1-10) was designed for evaluation as a selective COX-2 inhibitors and investigated in vivo for their anti-inflammatory activity.	cyclic imides	11-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
23528298-6	2013	The study showed that the homosulfonamide fragment of 8a inserted deep inside the 2 -pocket of the COX-2 active site, where the SO2NH2 group underwent H-bonding interaction with Gln(192)(2.95 A), Phe(518)(2.82 A) and Arg(513)(2.63 and 2.73 A).	homosulfonamide	26-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-104
23528298-6	2013	The study showed that the homosulfonamide fragment of 8a inserted deep inside the 2 -pocket of the COX-2 active site, where the SO2NH2 group underwent H-bonding interaction with Gln(192)(2.95 A), Phe(518)(2.82 A) and Arg(513)(2.63 and 2.73 A).	so2nh2	128-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-104
23528298-6	2013	The study showed that the homosulfonamide fragment of 8a inserted deep inside the 2 -pocket of the COX-2 active site, where the SO2NH2 group underwent H-bonding interaction with Gln(192)(2.95 A), Phe(518)(2.82 A) and Arg(513)(2.63 and 2.73 A).	Glutamine	178-181	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-104
23528298-6	2013	The study showed that the homosulfonamide fragment of 8a inserted deep inside the 2 -pocket of the COX-2 active site, where the SO2NH2 group underwent H-bonding interaction with Gln(192)(2.95 A), Phe(518)(2.82 A) and Arg(513)(2.63 and 2.73 A).	Phenylalanine	196-199	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-104
23528298-6	2013	The study showed that the homosulfonamide fragment of 8a inserted deep inside the 2 -pocket of the COX-2 active site, where the SO2NH2 group underwent H-bonding interaction with Gln(192)(2.95 A), Phe(518)(2.82 A) and Arg(513)(2.63 and 2.73 A).	Arginine	217-220	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-104
23528298-7	2013	Docking study of the synthesized compound 8a into the active site of COX-2 revealed a similar binding mode to SC-558, a selective COX-2 inhibitor.	SC 558	110-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-74
23528298-7	2013	Docking study of the synthesized compound 8a into the active site of COX-2 revealed a similar binding mode to SC-558, a selective COX-2 inhibitor.	SC 558	110-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	130-135
23330808-6	2013	Moreover, we found that the enhanced effects of UA and melatonin combination are mediated through simultaneous modulation of cytochrome c/caspase, MMP9/COX-2, and p300/NF-kappaB signaling pathways.	ursolic acid	48-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-157
23531445-6	2013	Fluorocoxib A was taken up by COX-2-expressing tumors but not by COX-2-negative human UMUC-3 xenograft tumors.	fluorocoxib A	0-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-35
23515290-3	2013	Correlations between cyclooxygenase (COX)-2 overexpression and enhanced production of prostaglandin (PG)E2 have been implicated in cancer progression; however, there are no studies indicating that TGF-beta effects in prostate cancer cells involve PGE2 synthesis.	Dinoprostone	86-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-43
23507189-14	2013	This study clearly shows that cryptolepine (CAS) inhibits neuroinflammation through mechanisms involving inhibition of COX-2 and mPGES-1.	cryptolepine	30-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-124
23330808-6	2013	Moreover, we found that the enhanced effects of UA and melatonin combination are mediated through simultaneous modulation of cytochrome c/caspase, MMP9/COX-2, and p300/NF-kappaB signaling pathways.	Melatonin	55-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-157
23330808-7	2013	Combined treatment with UA and melatonin triggered the release of cytochrome c from the mitochondrial intermembrane space into the cytosol, induced cleavage of caspase and PARP proteins, enhanced inhibition of MMP9 and COX-2 expression, promoted p300 and NF-kappaB translocation from cell nuclei to cytoplasm, and abrogated NF-kappaB binding and p300 recruitment to COX-2 promoter in colon cancer cells.	ursolic acid	24-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	219-224
23330808-7	2013	Combined treatment with UA and melatonin triggered the release of cytochrome c from the mitochondrial intermembrane space into the cytosol, induced cleavage of caspase and PARP proteins, enhanced inhibition of MMP9 and COX-2 expression, promoted p300 and NF-kappaB translocation from cell nuclei to cytoplasm, and abrogated NF-kappaB binding and p300 recruitment to COX-2 promoter in colon cancer cells.	ursolic acid	24-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	366-371
23330808-7	2013	Combined treatment with UA and melatonin triggered the release of cytochrome c from the mitochondrial intermembrane space into the cytosol, induced cleavage of caspase and PARP proteins, enhanced inhibition of MMP9 and COX-2 expression, promoted p300 and NF-kappaB translocation from cell nuclei to cytoplasm, and abrogated NF-kappaB binding and p300 recruitment to COX-2 promoter in colon cancer cells.	Melatonin	31-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	219-224
23330808-7	2013	Combined treatment with UA and melatonin triggered the release of cytochrome c from the mitochondrial intermembrane space into the cytosol, induced cleavage of caspase and PARP proteins, enhanced inhibition of MMP9 and COX-2 expression, promoted p300 and NF-kappaB translocation from cell nuclei to cytoplasm, and abrogated NF-kappaB binding and p300 recruitment to COX-2 promoter in colon cancer cells.	Melatonin	31-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	366-371
22715144-2	2013	A metal ion-chelating ligand complex with a Co(II) ion and a chelating reagent like ethylenediaminetetraacetic acid (EDTA) produced highly enhanced chemiluminescence (CL) intensity as well as longer lifetime in the luminol-H2 O2 system compared to metals that exist as free ions.	Oxygen	226-228	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-50
22715144-4	2013	Based on the observed phenomenon, it was possible to determine Co(II), Fe(II) and Cr(III) ions with enhanced sensitivity and selectivity using the chelating reagents of the luminol-H2 O2 system.	tris(1,10-phenanthroline)chromium(III) chloride	82-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-69
22715144-0	2013	A chelate complex-enhanced luminol system for selective determination of Co(II), Fe(II) and Cr(III).	Luminol	27-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-79
22715144-1	2013	A determination method for Co(II), Fe(II) and Cr(III) ions by luminol-H2 O2 system using chelating reagents is presented.	Luminol	62-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-33
22715144-4	2013	Based on the observed phenomenon, it was possible to determine Co(II), Fe(II) and Cr(III) ions with enhanced sensitivity and selectivity using the chelating reagents of the luminol-H2 O2 system.	Luminol	173-180	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-69
22715144-1	2013	A determination method for Co(II), Fe(II) and Cr(III) ions by luminol-H2 O2 system using chelating reagents is presented.	Hydrogen Peroxide	70-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-33
22715144-4	2013	Based on the observed phenomenon, it was possible to determine Co(II), Fe(II) and Cr(III) ions with enhanced sensitivity and selectivity using the chelating reagents of the luminol-H2 O2 system.	Hydrogen Peroxide	181-186	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-69
22715144-2	2013	A metal ion-chelating ligand complex with a Co(II) ion and a chelating reagent like ethylenediaminetetraacetic acid (EDTA) produced highly enhanced chemiluminescence (CL) intensity as well as longer lifetime in the luminol-H2 O2 system compared to metals that exist as free ions.	Metals	2-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-50
22715144-2	2013	A metal ion-chelating ligand complex with a Co(II) ion and a chelating reagent like ethylenediaminetetraacetic acid (EDTA) produced highly enhanced chemiluminescence (CL) intensity as well as longer lifetime in the luminol-H2 O2 system compared to metals that exist as free ions.	Edetic Acid	84-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-50
22715144-5	2013	The effects of ligand, H2 O2 concentration, pH, buffer solution and concentrations of chelating reagents on CL intensity of the luminol-H2 O2 system were investigated and optimized for the determination of Co(II), Fe(II) and Cr(III) ions.	Hydrogen Peroxide	136-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	206-212
22715144-2	2013	A metal ion-chelating ligand complex with a Co(II) ion and a chelating reagent like ethylenediaminetetraacetic acid (EDTA) produced highly enhanced chemiluminescence (CL) intensity as well as longer lifetime in the luminol-H2 O2 system compared to metals that exist as free ions.	Edetic Acid	117-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-50
22715144-6	2013	Under optimized conditions, the calibration curve of metal ions was linear over the range of 2.0 x 10(-8) to 2.0 x 10(-5) M for Co(II), 1.0 x 10(-7) to 2.0 x 10(-5) M for Fe (II) and 2.0 x 10(-7) to 1.0 x 10(-4) M for Cr(III).	Metals	53-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	128-133
22715144-2	2013	A metal ion-chelating ligand complex with a Co(II) ion and a chelating reagent like ethylenediaminetetraacetic acid (EDTA) produced highly enhanced chemiluminescence (CL) intensity as well as longer lifetime in the luminol-H2 O2 system compared to metals that exist as free ions.	Luminol	215-222	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-50
22715144-2	2013	A metal ion-chelating ligand complex with a Co(II) ion and a chelating reagent like ethylenediaminetetraacetic acid (EDTA) produced highly enhanced chemiluminescence (CL) intensity as well as longer lifetime in the luminol-H2 O2 system compared to metals that exist as free ions.	Hydrogen	223-225	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-50
22715144-6	2013	Under optimized conditions, the calibration curve of metal ions was linear over the range of 2.0 x 10(-8) to 2.0 x 10(-5) M for Co(II), 1.0 x 10(-7) to 2.0 x 10(-5) M for Fe (II) and 2.0 x 10(-7) to 1.0 x 10(-4) M for Cr(III).	fe (ii)	171-178	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	128-133
22715144-6	2013	Under optimized conditions, the calibration curve of metal ions was linear over the range of 2.0 x 10(-8) to 2.0 x 10(-5) M for Co(II), 1.0 x 10(-7) to 2.0 x 10(-5) M for Fe (II) and 2.0 x 10(-7) to 1.0 x 10(-4) M for Cr(III).	tris(1,10-phenanthroline)chromium(III) chloride	218-225	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	128-133
23427297-12	2013	Tandutinib treatment also inhibited the expression of cancer-promoting genes COX-2 and VEGF and suppressed the activation of Akt/mTOR signaling proteins in the xenograft tissues.	tandutinib	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-82
23488692-8	2013	Stimulation of SFs with HMGB1 in complex with suboptimal amounts of IL-1beta significantly increased mPGES-1 and COX-2 expressions as well as PGE2 production, as compared to treatment with HMGB1 or IL-1beta alone.	SFS	15-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-118
23545701-4	2013	In the present study, RPMI8226 MM cells were treated with the Cox-2 inhibitor NS-398 to investigate whether it enhanced the effect of bortezomib on MM.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	78-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
23761819-9	2013	Furthermore, canolol downregulated the mRNA levels of COX-2, but had no significant effect on the mRNA expession of the Bax and Bcl-2 genes.	4-vinyl-2,6-dimethoxyphenol	13-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-59
23565678-1	2013	Celecoxib, a tricyclic compound having pyrazole ring exhibits an excellent level of antiinflammatory action against COX-2 enzymes and some of its analogs act as anticancer and antibacterial agents.	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-121
23565678-1	2013	Celecoxib, a tricyclic compound having pyrazole ring exhibits an excellent level of antiinflammatory action against COX-2 enzymes and some of its analogs act as anticancer and antibacterial agents.	pyrazole	39-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-121
23658734-8	2013	Indeed, 1,8-naphthyridin-2-one derivative reduced the levels of Cox-2 in lymphocytes from patients whereas no effect was observed in control cells.	1,8-naphthyridin-2(1H)-one	8-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-69
23646189-5	2013	RESULTS: 8-CPT-2Me-cAMP treatment caused a 2-2.5-fold increase of p-cPLA2(S505), COX-2, and PGE2 levels in human prostate cancer cell lines.	8-(4-chloro-phenylthio)-2'-O-methyladenosine-3'-5'-cyclic monophosphate	9-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-86
23646189-6	2013	Pretreatment of cells with the COX-2 inhibitor SC-58125 or the EP4 antagonist AH-23848, or with an inhibitor of mTORC1 and mTORC2, Torin1, significantly reduced the Epac1-dependent increase of p-cPLA2 and COX-2, p-S6-kinase(T389), and p-AKT(S473).	1-((4-methylsulfonyl)phenyl)-3-trifluoromethyl-5-(4-fluorophenyl)pyrazole	47-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-36
23646189-6	2013	Pretreatment of cells with the COX-2 inhibitor SC-58125 or the EP4 antagonist AH-23848, or with an inhibitor of mTORC1 and mTORC2, Torin1, significantly reduced the Epac1-dependent increase of p-cPLA2 and COX-2, p-S6-kinase(T389), and p-AKT(S473).	1-((4-methylsulfonyl)phenyl)-3-trifluoromethyl-5-(4-fluorophenyl)pyrazole	47-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	205-210
23646189-6	2013	Pretreatment of cells with the COX-2 inhibitor SC-58125 or the EP4 antagonist AH-23848, or with an inhibitor of mTORC1 and mTORC2, Torin1, significantly reduced the Epac1-dependent increase of p-cPLA2 and COX-2, p-S6-kinase(T389), and p-AKT(S473).	AH 23848	78-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	205-210
23416140-1	2013	To investigate mechanisms of neuronal cell death in response to chlorpyrifos (CPF), a pesticide, we evaluated the regulation of ROS and COX-2 in human neuroblastoma SH-SY5Y cells treated with CPF.	Chlorpyrifos	64-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	136-141
23462930-6	2013	The crystal structures of all the studied hetero-trinuclear species highlight that such systems are formed thanks to the synergy between the different stereochemical requirement of the transition metal (Cu(II) or Co(II)) and the different donor atoms set of the ligands which preorganize the maltol units for the binding of the hard M(III) metal, otherwise difficult to bind in water, through L/M(II)/M(III) self-assembling.	Metals	196-201	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	213-219
23462930-6	2013	The crystal structures of all the studied hetero-trinuclear species highlight that such systems are formed thanks to the synergy between the different stereochemical requirement of the transition metal (Cu(II) or Co(II)) and the different donor atoms set of the ligands which preorganize the maltol units for the binding of the hard M(III) metal, otherwise difficult to bind in water, through L/M(II)/M(III) self-assembling.	maltol	292-298	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	213-219
23462930-6	2013	The crystal structures of all the studied hetero-trinuclear species highlight that such systems are formed thanks to the synergy between the different stereochemical requirement of the transition metal (Cu(II) or Co(II)) and the different donor atoms set of the ligands which preorganize the maltol units for the binding of the hard M(III) metal, otherwise difficult to bind in water, through L/M(II)/M(III) self-assembling.	Metals	340-345	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	213-219
23462930-6	2013	The crystal structures of all the studied hetero-trinuclear species highlight that such systems are formed thanks to the synergy between the different stereochemical requirement of the transition metal (Cu(II) or Co(II)) and the different donor atoms set of the ligands which preorganize the maltol units for the binding of the hard M(III) metal, otherwise difficult to bind in water, through L/M(II)/M(III) self-assembling.	Water	378-383	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	213-219
23534442-2	2013	New classes of pyrrole-derived nitrooxyalkyl inverse esters, carbonates, and ethers (7-10) as COX-2 selective inhibitors and NO donors were synthesized and are herein reported.	pyrrole-derived nitrooxyalkyl inverse esters	15-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-99
23658609-4	2013	We and others have reported that prostaglandin E3 (PGE3), derived from COX-2 metabolism of the omega-3 fatty acid eicosapentaenoic acid (EPA), inhibited the proliferation of human lung, colon and pancreatic cancer cells.	prostaglandin E3	33-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-76
23658609-4	2013	We and others have reported that prostaglandin E3 (PGE3), derived from COX-2 metabolism of the omega-3 fatty acid eicosapentaenoic acid (EPA), inhibited the proliferation of human lung, colon and pancreatic cancer cells.	prostaglandin E3	51-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-76
23658609-4	2013	We and others have reported that prostaglandin E3 (PGE3), derived from COX-2 metabolism of the omega-3 fatty acid eicosapentaenoic acid (EPA), inhibited the proliferation of human lung, colon and pancreatic cancer cells.	Fatty Acids, Omega-3	95-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-76
23658609-4	2013	We and others have reported that prostaglandin E3 (PGE3), derived from COX-2 metabolism of the omega-3 fatty acid eicosapentaenoic acid (EPA), inhibited the proliferation of human lung, colon and pancreatic cancer cells.	Eicosapentaenoic Acid	114-135	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-76
23658609-4	2013	We and others have reported that prostaglandin E3 (PGE3), derived from COX-2 metabolism of the omega-3 fatty acid eicosapentaenoic acid (EPA), inhibited the proliferation of human lung, colon and pancreatic cancer cells.	Eicosapentaenoic Acid	137-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-76
23534442-2	2013	New classes of pyrrole-derived nitrooxyalkyl inverse esters, carbonates, and ethers (7-10) as COX-2 selective inhibitors and NO donors were synthesized and are herein reported.	Carbonates	61-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-99
23534442-2	2013	New classes of pyrrole-derived nitrooxyalkyl inverse esters, carbonates, and ethers (7-10) as COX-2 selective inhibitors and NO donors were synthesized and are herein reported.	Ethers	77-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-99
23534442-7	2013	Finally, molecular modeling and (1)H- and (13)C-NMR studies performed on compounds 6c,d, 9c, and 10b allowed the right conformation of nitrooxyalkyl ester and ether side chain of these molecules within the COX-2 active site to be assessed.	nitrooxyalkyl ester	135-154	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	206-211
23637886-4	2013	And H(H2O)m significantly prevented UV-induced MMP-1, COX-2, IL-6 and IL-1beta mRNA expressions in human skin in vivo.	Water	6-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-59
23506332-0	2013	Triazole-linked anthracenyl-appended calix[4]arene conjugate as receptor for Co(II): synthesis, spectroscopy, microscopy, and computational studies.	Triazoles	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-83
23637886-5	2013	We found that H(H2O)m prevented UV-induced ROS generation and inhibited UV-induced MMP-1, COX-2 and IL-6 expressions, and UV-induced JNK and c-Jun phosphorylation in HaCaT cells.	Water	16-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-95
23435550-0	2013	First structurally characterized self-assembly of bipodal N-thiophosphorylated bis-thiourea with Co(II): magnetic properties and thermal decomposition.	Nitrogen	58-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-103
23435550-0	2013	First structurally characterized self-assembly of bipodal N-thiophosphorylated bis-thiourea with Co(II): magnetic properties and thermal decomposition.	bis-thiourea	79-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-103
23435550-3	2013	Reaction of doubly deprotonated L with Co(II) leads to the [Co2L2] complex.	co2l2	60-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-45
23411617-0	2013	Defective dicubanes of Co(II)/Co(III) complexes with triethanolamine and N-donors.	triethanolamine	53-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-29
23411617-0	2013	Defective dicubanes of Co(II)/Co(III) complexes with triethanolamine and N-donors.	n-donors	73-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-29
23411617-3	2013	In 1, the central rhombic core Co2O2 is occupied by two Co(III) ions while the external cobalt atoms display Co(II) oxidation states; meanwhile 2 and 3 exhibit a reversal in their Co(II)2Co(III)2 oxidation state distribution.	Cobalt	88-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-115
23506332-0	2013	Triazole-linked anthracenyl-appended calix[4]arene conjugate as receptor for Co(II): synthesis, spectroscopy, microscopy, and computational studies.	anthracenyl	16-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-83
23620771-0	2013	The association between COX-2 polymorphisms and hematologic toxicity in patients with advanced non-small-cell lung cancer treated with platinum-based chemotherapy.	Platinum	135-143	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
23620771-3	2013	This study aimed at investigating the association between COX-2 polymorphisms and the occurrence of grade 3 or 4 toxicity in advanced non-small cell lung cancer patients treated with platinum-based chemotherapy.	Platinum	183-191	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
23506332-0	2013	Triazole-linked anthracenyl-appended calix[4]arene conjugate as receptor for Co(II): synthesis, spectroscopy, microscopy, and computational studies.	calix(4)arene	37-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-83
23557586-1	2013	The reaction of the multisite coordination ligand (LH4) with CoX2 nH2O in the presence of tetrabutylammonium hydroxide affords a series of homometallic dinuclear mixed-valence complexes, [Co(III)Co(II)(LH2)2(X)(H2O)](H2O)m (1, X = Cl and m = 4; 2, X = Br and m = 4; 3, X = NO3 and m = 3).	5-[(3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4- d]imidazolidin-4-yl]-N'-{2,6-bis[4-(morpholine-4- sulfonyl)phenyl]phenyl}pentanehydrazide	51-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-65
23473947-4	2013	In molecular modeling, interaction of 2-sulfonylalkyl moiety with Arg120 in COX-1 and an extra hydrogen bond with Tyr341 in COX-2 increased the residence time of ligands in the active site in 2-sulfonylalkyl and 2-alkylthio analogs, respectively.	2-sulfonylalkyl	38-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	124-129
23473947-4	2013	In molecular modeling, interaction of 2-sulfonylalkyl moiety with Arg120 in COX-1 and an extra hydrogen bond with Tyr341 in COX-2 increased the residence time of ligands in the active site in 2-sulfonylalkyl and 2-alkylthio analogs, respectively.	Hydrogen	95-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	124-129
23551211-1	2013	This report describes the synthesis, characterization, and magnetic properties of two novel phosphonate-based Co(II) cages.	Organophosphonates	92-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-116
23886271-3	2013	The effects of COX-2 silencing on the proliferation, cell cycle and migration of SaOS2 cells were assessed by thiazolyl blue tetrazolium bromide, flow cytometry and migration assays respectively.	thiazolyl blue	110-144	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-20
23886271-5	2013	RESULTS: A decreased expression of COX-2 in human osteosarcoma cells significantly inhibited the growth and decreased the migration ability of SaOS2 cells.	saos2	143-148	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40
23656559-6	2013	Based on the available information, most people with clearly elevated serum Co, like supplement users and hip implant patients, have &gt;90% of Co as albumin-bound, with considerable excess binding capacity to sequester Co(II) ions.	Cobalt	76-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	220-226
23517550-3	2013	Recent theoretical calculations raised a new proposal that the Co(salen)(H2O)(SbF6) complex contains appreciable contribution from a Co(II)(salen( +)) electronic structure (Kochem, A.; Kanso, H.; Baptiste, B.; Arora, H.; Philouze, C.; Jarjayes, O.; Vezin, H.; Luneau, D.; Orio, M.; Thomas, F. Inorg.	co(salen)(	63-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	133-139
23517550-3	2013	Recent theoretical calculations raised a new proposal that the Co(salen)(H2O)(SbF6) complex contains appreciable contribution from a Co(II)(salen( +)) electronic structure (Kochem, A.; Kanso, H.; Baptiste, B.; Arora, H.; Philouze, C.; Jarjayes, O.; Vezin, H.; Luneau, D.; Orio, M.; Thomas, F. Inorg.	Water	73-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	133-139
23517550-3	2013	Recent theoretical calculations raised a new proposal that the Co(salen)(H2O)(SbF6) complex contains appreciable contribution from a Co(II)(salen( +)) electronic structure (Kochem, A.; Kanso, H.; Baptiste, B.; Arora, H.; Philouze, C.; Jarjayes, O.; Vezin, H.; Luneau, D.; Orio, M.; Thomas, F. Inorg.	sbf6)	78-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	133-139
23517550-15	2013	The CH2Cl2 solution of Co(salen)(X) shows an intense near-IR absorption, which is assigned as overlapped transitions from a ligand-to-metal charge transfer in Co(III)(salen)(X) and a ligand-to-ligand charge transfer in Co(II)(salen( +))(X).	Methylene Chloride	4-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	219-225
23517550-15	2013	The CH2Cl2 solution of Co(salen)(X) shows an intense near-IR absorption, which is assigned as overlapped transitions from a ligand-to-metal charge transfer in Co(III)(salen)(X) and a ligand-to-ligand charge transfer in Co(II)(salen( +))(X).	SALCOMINE	23-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	219-225
24520457-3	2013	Celecoxib is a selective inhibitor of COX-2 with numerous pharmacologic functions.	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-43
23333714-8	2013	Here, we first report the acting of Co(II)(Chro)2, the groove-binding drug, to trinucleotide repeats.	trinucleotide	79-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-49
23357220-2	2013	Nonsteroidal anti-inflammatory drugs reduce production of prostanoids including PGE2 by inhibiting COX-1 and/or COX-2, and thereby suppress inflammatory pain in patients suffering from rheumatoid arthritis, osteoarthritis, and migraine.	Prostaglandins	58-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-117
23357220-2	2013	Nonsteroidal anti-inflammatory drugs reduce production of prostanoids including PGE2 by inhibiting COX-1 and/or COX-2, and thereby suppress inflammatory pain in patients suffering from rheumatoid arthritis, osteoarthritis, and migraine.	Dinoprostone	80-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-117
23579701-5	2013	In both polymorphic forms, the dinuclear complex molecules are located on a crystallographic centre of inversion, with the Co(II) cations in a distorted octahedral environment consisting of a chloride ligand, three pyridine ligands and a chelating bis-bidentate oxalate ligand.	Chlorides	192-200	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-129
23067366-2	2013	Short-term 8-week celecoxib, a selective COX-2 inhibitor, exerts a preliminary hint to improve regression in part for persistent IM after Helicobacter pylori eradication.	Celecoxib	18-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-46
23067366-10	2013	Even in the patients without IM regression, the mean IM scores and COX-2 expressions were significantly more decreased in the celecoxib group than in the controls (p &lt; .005).	Celecoxib	126-135	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-72
23755755-2	2013	The objectives of this study were to evaluate in Thai healthy volunteers: i) the inhibition of whole blood cyclooxygenase(COX)-2 and COX-1 activity by floctafenine and its metabolite floctafenic acid in vitro and ex vivo after dosing with floctafenine; ii) the possible interference of floctafenine administration with aspirin antiplatelet effects.	floctafenine	151-163	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-128
23755755-2	2013	The objectives of this study were to evaluate in Thai healthy volunteers: i) the inhibition of whole blood cyclooxygenase(COX)-2 and COX-1 activity by floctafenine and its metabolite floctafenic acid in vitro and ex vivo after dosing with floctafenine; ii) the possible interference of floctafenine administration with aspirin antiplatelet effects.	floctafenic acid	183-199	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-128
23755755-4	2013	Floctafenine and floctafenic acid resulted potent inhibitors of COX-1 and COX-2 in vitro (floctafenic acid was more potent than floctafenine) showing a slight preference for COX-1.	floctafenine	0-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
23755755-4	2013	Floctafenine and floctafenic acid resulted potent inhibitors of COX-1 and COX-2 in vitro (floctafenic acid was more potent than floctafenine) showing a slight preference for COX-1.	floctafenic acid	17-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
23755755-4	2013	Floctafenine and floctafenic acid resulted potent inhibitors of COX-1 and COX-2 in vitro (floctafenic acid was more potent than floctafenine) showing a slight preference for COX-1.	floctafenic acid	90-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
23755755-4	2013	Floctafenine and floctafenic acid resulted potent inhibitors of COX-1 and COX-2 in vitro (floctafenic acid was more potent than floctafenine) showing a slight preference for COX-1.	floctafenine	128-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
23755755-5	2013	After dosing with floctafenine alone, whole blood COX-1 and COX-2 activities were inhibited ex vivo in a time-dependent fashion which paralleled floctafenic acid plasma concentrations.	floctafenine	18-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-65
23755755-5	2013	After dosing with floctafenine alone, whole blood COX-1 and COX-2 activities were inhibited ex vivo in a time-dependent fashion which paralleled floctafenic acid plasma concentrations.	floctafenic acid	145-161	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-65
23333714-2	2013	This study focused on the binding of the Co(II) complex of dimeric chromomycin A3(Chro), Co(II)(Chro)2, to DNA with CXG trinucleotide repeats.	Chromomycin A3	67-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-47
23333714-2	2013	This study focused on the binding of the Co(II) complex of dimeric chromomycin A3(Chro), Co(II)(Chro)2, to DNA with CXG trinucleotide repeats.	Chromomycin A3	67-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-102
23333714-2	2013	This study focused on the binding of the Co(II) complex of dimeric chromomycin A3(Chro), Co(II)(Chro)2, to DNA with CXG trinucleotide repeats.	trinucleotide	120-133	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-47
23333714-2	2013	This study focused on the binding of the Co(II) complex of dimeric chromomycin A3(Chro), Co(II)(Chro)2, to DNA with CXG trinucleotide repeats.	trinucleotide	120-133	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-102
23566058-8	2013	Our result suggests that Oligonol has the potential to suppress increases in body temperature under heat stress, and this is associated with decreases in serum levels of PGE2 and COX-2.	oligonol	25-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	179-184
23763181-1	2013	Different phases in hybrid complexes of Co(II) with cis-4-cyclohexene-1-2-dicarboxylicacid (C6H8-1,2-CO2H=Cy-H2) have been generated depending on the reaction conditions.	cis-4-cyclohexene-1-2-dicarboxylicacid	52-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-46
23763181-1	2013	Different phases in hybrid complexes of Co(II) with cis-4-cyclohexene-1-2-dicarboxylicacid (C6H8-1,2-CO2H=Cy-H2) have been generated depending on the reaction conditions.	c6h8-1,2-co2h	92-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-46
23763181-1	2013	Different phases in hybrid complexes of Co(II) with cis-4-cyclohexene-1-2-dicarboxylicacid (C6H8-1,2-CO2H=Cy-H2) have been generated depending on the reaction conditions.	cy-h2	106-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-46
23629578-2	2013	Classical non-steroidal anti-inflammatory drugs (NSAID) inhibit the COX-2 enzyme that produces inflammatory prostaglandins as well as the COX-1 enzyme that produces gastric mucosa protecting prostaglandins.	Prostaglandins	108-122	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-73
23629578-4	2013	However, COX-2 at the vascular endothelium produces antithrombotic prostaglandins, and so by inhibiting COX-2 enzyme, the coxibs promote thrombosis.	Prostaglandins	67-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	9-14
23629578-4	2013	However, COX-2 at the vascular endothelium produces antithrombotic prostaglandins, and so by inhibiting COX-2 enzyme, the coxibs promote thrombosis.	Prostaglandins	67-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
23012315-6	2013	Vitamin D also attenuated IL-1beta-induced MCP-1, IL-6, connexin 43, cyclooxygenase (COX)-2, and prostaglandin receptor expression.	Vitamin D	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-91
23555156-8	2013	The factors associated with an increased risk of upper gastrointestinal (GI) complications in subjects taking LDA are aspirin dose, history of ulcer or upper GI bleeding, age &gt; 70 years, concomitant use of non-aspirin NSAIDs including COX-2-selective NSAIDs, and Helicobacter pylori (H. pylori) infection.	lda	110-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	238-243
23506529-3	2013	Aspirin is a non-steroidal anti-inflammatory drug that is an irreversible inhibitor of both cyclooxygenase (COX)-1 and COX-2, It stimulates endogenous production of anti-inflammatory regulatory "braking signals", including lipoxins, which dampen the inflammatory response and reduce levels of inflammatory biomarkers, including C-reactive protein, tumor necrosis factor-alpha and interleukin (IL)--6, but not negative immunoregulatory cytokines, such as IL-4 and IL-10.	Aspirin	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-124
23634005-1	2013	In the title compound, [Co(C7H4ClO2)2(C5H5N)2(H2O)], the Co(II) atom is six-coordinated by three O atoms from a bidentate and a monodentate 4-chloro-benzoate ligand, two N atoms from two pyridine ligands and a water O atom, giving a distorted octa-hedral geometry.	co(c7h4clo2)2(c5h5n)2(h2o)	24-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-63
23634005-1	2013	In the title compound, [Co(C7H4ClO2)2(C5H5N)2(H2O)], the Co(II) atom is six-coordinated by three O atoms from a bidentate and a monodentate 4-chloro-benzoate ligand, two N atoms from two pyridine ligands and a water O atom, giving a distorted octa-hedral geometry.	4-chlorobenzoic acid	140-157	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-63
23634005-1	2013	In the title compound, [Co(C7H4ClO2)2(C5H5N)2(H2O)], the Co(II) atom is six-coordinated by three O atoms from a bidentate and a monodentate 4-chloro-benzoate ligand, two N atoms from two pyridine ligands and a water O atom, giving a distorted octa-hedral geometry.	Nitrogen	42-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-63
23634005-1	2013	In the title compound, [Co(C7H4ClO2)2(C5H5N)2(H2O)], the Co(II) atom is six-coordinated by three O atoms from a bidentate and a monodentate 4-chloro-benzoate ligand, two N atoms from two pyridine ligands and a water O atom, giving a distorted octa-hedral geometry.	pyridine	187-195	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-63
23634005-1	2013	In the title compound, [Co(C7H4ClO2)2(C5H5N)2(H2O)], the Co(II) atom is six-coordinated by three O atoms from a bidentate and a monodentate 4-chloro-benzoate ligand, two N atoms from two pyridine ligands and a water O atom, giving a distorted octa-hedral geometry.	Water	210-215	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-63
23634005-1	2013	In the title compound, [Co(C7H4ClO2)2(C5H5N)2(H2O)], the Co(II) atom is six-coordinated by three O atoms from a bidentate and a monodentate 4-chloro-benzoate ligand, two N atoms from two pyridine ligands and a water O atom, giving a distorted octa-hedral geometry.	octa-hedral	243-254	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-63
23261351-4	2013	The supported Co catalysts presented higher activity in activation of OXONE  for phenol degradation due to higher dispersion of Co(3)O(4) on the supports and Co(II) coordination sites.	potassium peroxymonosulfuric acid	70-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	158-163
23261351-4	2013	The supported Co catalysts presented higher activity in activation of OXONE  for phenol degradation due to higher dispersion of Co(3)O(4) on the supports and Co(II) coordination sites.	Phenol	81-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	158-163
23344965-1	2013	Subtle differences in metal-ligand bond lengths between a series of [M(4)L(6)](4-) tetrahedral cages, where M = Fe(II), Co(II), or Ni(II), were observed to result in substantial differences in affinity for hydrophobic guests in water.	Water	228-233	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-126
23386517-1	2013	A change for the better: Exchange of Cd(II) in the catalytically inactive framework MMPF-5 (see scheme) with Co(II) afforded a metalloporphyrin-based nanoreactor, MMPF-5(Co).	cd(ii)	37-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-115
23386517-1	2013	A change for the better: Exchange of Cd(II) in the catalytically inactive framework MMPF-5 (see scheme) with Co(II) afforded a metalloporphyrin-based nanoreactor, MMPF-5(Co).	mmpf-5	84-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-115
23386517-1	2013	A change for the better: Exchange of Cd(II) in the catalytically inactive framework MMPF-5 (see scheme) with Co(II) afforded a metalloporphyrin-based nanoreactor, MMPF-5(Co).	Metalloporphyrins	127-143	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-115
23386517-1	2013	A change for the better: Exchange of Cd(II) in the catalytically inactive framework MMPF-5 (see scheme) with Co(II) afforded a metalloporphyrin-based nanoreactor, MMPF-5(Co).	mmpf-5	163-169	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-115
23398593-1	2013	The synthesis and characterization of a 4-fold-interpenetrated pseudodiamond metal-organic framework (MOF), Co(II)(pybz)2 2DMF [pybz = 4-(4-pyridyl)benzoate], are reported.	pybz	115-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-114
23398593-1	2013	The synthesis and characterization of a 4-fold-interpenetrated pseudodiamond metal-organic framework (MOF), Co(II)(pybz)2 2DMF [pybz = 4-(4-pyridyl)benzoate], are reported.	4-(4-pyridyl)benzoate	135-156	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-114
23398593-10	2013	The desolvated Co(II)(pybz)2 can absorb several gases such as CO2, N2, H2, and CH4 and also vapors of methanol, ethanol, benzene, and cyclohexane.	N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)-4-((4-fluorobenzyl)oxy)pyridine-2,6-dicarboxamide	62-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-21
23398593-10	2013	The desolvated Co(II)(pybz)2 can absorb several gases such as CO2, N2, H2, and CH4 and also vapors of methanol, ethanol, benzene, and cyclohexane.	Nitrogen	67-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-21
23398593-10	2013	The desolvated Co(II)(pybz)2 can absorb several gases such as CO2, N2, H2, and CH4 and also vapors of methanol, ethanol, benzene, and cyclohexane.	Hydrogen	71-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-21
23398593-10	2013	The desolvated Co(II)(pybz)2 can absorb several gases such as CO2, N2, H2, and CH4 and also vapors of methanol, ethanol, benzene, and cyclohexane.	Methane	79-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-21
23398593-10	2013	The desolvated Co(II)(pybz)2 can absorb several gases such as CO2, N2, H2, and CH4 and also vapors of methanol, ethanol, benzene, and cyclohexane.	Methanol	102-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-21
23398593-10	2013	The desolvated Co(II)(pybz)2 can absorb several gases such as CO2, N2, H2, and CH4 and also vapors of methanol, ethanol, benzene, and cyclohexane.	Ethanol	103-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-21
23398593-10	2013	The desolvated Co(II)(pybz)2 can absorb several gases such as CO2, N2, H2, and CH4 and also vapors of methanol, ethanol, benzene, and cyclohexane.	Benzene	121-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-21
23398593-10	2013	The desolvated Co(II)(pybz)2 can absorb several gases such as CO2, N2, H2, and CH4 and also vapors of methanol, ethanol, benzene, and cyclohexane.	Cyclohexane	134-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-21
23453006-0	2013	Effects of ectopic HER-2/neu gene expression on the COX-2/PGE2/P450arom signaling pathway in endometrial carcinoma cells: HER-2/neu gene expression in endometrial carcinoma cells.	Dinoprostone	58-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-57
23339966-6	2013	Interestingly, docking of the two active molecules 3k and 3w into the active site of COX-2 indicates that these compounds are COX-2 ligands with strong hydrophobic and hydrogen bonding interactions.	Hydrogen	168-176	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-90
23339966-6	2013	Interestingly, docking of the two active molecules 3k and 3w into the active site of COX-2 indicates that these compounds are COX-2 ligands with strong hydrophobic and hydrogen bonding interactions.	Hydrogen	168-176	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-131
22941037-0	2013	Sinomenine hydrochloride enhancement of the inhibitory effects of anti-transferrin receptor antibody-dependent on the COX-2 pathway in human hepatoma cells.	sinomenine	0-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-123
22941037-7	2013	In contrast, COX-2 expression was dramatically decreased in HepG2 cells treated with sinomenine hydrochloride alone.	sinomenine	85-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
22941037-9	2013	To sum up, these results showed that the combined use of sinomenine hydrochloride and anti-TfR mAb may exert synergistic inhibitory effects on human hepatoma HepG2 cells in a COX-2-dependent manner.	sinomenine	57-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	175-180
23268707-10	2013	Apoptosis was induced in irradiated cells 48 hours after treatment with celecoxib dependent of COX-2.	Celecoxib	72-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-100
23321929-9	2013	Next, to confirm COX-2 as a source for 4-HNE, we assayed the products generated by recombinant human COX-2 and found 4-HNE in a concentration-dependent manner using arachidonic acid as a substrate.	Arachidonic Acid	165-181	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22
23321929-9	2013	Next, to confirm COX-2 as a source for 4-HNE, we assayed the products generated by recombinant human COX-2 and found 4-HNE in a concentration-dependent manner using arachidonic acid as a substrate.	Arachidonic Acid	165-181	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-106
23321929-12	2013	These data show that E. faecalis, a human intestinal commensal, can trigger macrophages to produce 4-HNE through COX-2.	4-hydroxy-2-nonenal	99-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-118
23250922-6	2013	SOPs-impaired vasorelaxation was completely reversed by cyclooxygenase (COX)-2 inhibitor DuP-697, whereas the reversal by COX-1 inhibitor SC-560 was only partial.	DuP 697	89-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-78
23250922-13	2013	SOPs decreased cGMP production, and the effect could be reversed by inhibiting COX-2 or TP receptor.	Cyclic GMP	15-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-84
23506493-3	2013	RESULTS: NO and peroxynitrite are mainly responsible for vasoplegia and vascular hyporeactivity while COX 2 enzyme is responsible for the increase in PGI2, which also contributes to hyporeactivity.	Epoprostenol	150-154	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-107
22810378-4	2013	The optimum pH range for the maximum sorption of Ni(II), Mn(II), Cu(II), Zn(II), Cd(II), Cr(III), and Co(II) was observed at pH 5.5-8.0 with the corresponding half-loading time (t                 (1/2)) of 9, 5, 9, 9, 3, 9, and 5 min, respectively.	Nickel(2+)	49-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-108
22810378-4	2013	The optimum pH range for the maximum sorption of Ni(II), Mn(II), Cu(II), Zn(II), Cd(II), Cr(III), and Co(II) was observed at pH 5.5-8.0 with the corresponding half-loading time (t                 (1/2)) of 9, 5, 9, 9, 3, 9, and 5 min, respectively.	Manganese(2+)	57-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-108
23557586-1	2013	The reaction of the multisite coordination ligand (LH4) with CoX2 nH2O in the presence of tetrabutylammonium hydroxide affords a series of homometallic dinuclear mixed-valence complexes, [Co(III)Co(II)(LH2)2(X)(H2O)](H2O)m (1, X = Cl and m = 4; 2, X = Br and m = 4; 3, X = NO3 and m = 3).	tetrabutylammonium	90-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-65
23557586-1	2013	The reaction of the multisite coordination ligand (LH4) with CoX2 nH2O in the presence of tetrabutylammonium hydroxide affords a series of homometallic dinuclear mixed-valence complexes, [Co(III)Co(II)(LH2)2(X)(H2O)](H2O)m (1, X = Cl and m = 4; 2, X = Br and m = 4; 3, X = NO3 and m = 3).	co(iii)	188-195	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-65
23557586-1	2013	The reaction of the multisite coordination ligand (LH4) with CoX2 nH2O in the presence of tetrabutylammonium hydroxide affords a series of homometallic dinuclear mixed-valence complexes, [Co(III)Co(II)(LH2)2(X)(H2O)](H2O)m (1, X = Cl and m = 4; 2, X = Br and m = 4; 3, X = NO3 and m = 3).	Water	211-215	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-65
23557586-1	2013	The reaction of the multisite coordination ligand (LH4) with CoX2 nH2O in the presence of tetrabutylammonium hydroxide affords a series of homometallic dinuclear mixed-valence complexes, [Co(III)Co(II)(LH2)2(X)(H2O)](H2O)m (1, X = Cl and m = 4; 2, X = Br and m = 4; 3, X = NO3 and m = 3).	Water	67-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-65
23357750-4	2013	In the interference study, Co(II) was selectivity extracted in the top phase in the presence of Ni(II) and Cd(II) in a concentration of up to 20 times the cobalt level in the system.	Nickel(2+)	96-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-33
23059845-11	2013	Non-transfected and hCOX-2-transfected cells were cultured at 5 and 25 mM of glucose by 72 h. At 25 mM there was an increase in apoptosis in non-transfected cells versus those exposed to 5 mM.	Glucose	77-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-26
23059845-13	2013	Moreover, the protective effect observed in hCOX-2-transfected cells was suppressed by addition of DFU (COX-2 selective inhibitor), and mimicked by addition of PGE(2) in non-transfected cells.	5,5-dimethyl-3-(3-fluorophenyl)-4-(4-methylsulfonyl)phenyl-2(5H)-furanone	99-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-50
23059845-13	2013	Moreover, the protective effect observed in hCOX-2-transfected cells was suppressed by addition of DFU (COX-2 selective inhibitor), and mimicked by addition of PGE(2) in non-transfected cells.	Prostaglandins E	160-163	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-50
23338544-1	2013	We have previously shown that specific COX-2 inhibitors, including DuP 697, have anti-proliferative effects on mesothelioma cells and potentiate the cytotoxicity of pemetrexed.	Pemetrexed	165-175	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-44
23232839-0	2013	Endothelial dysfunction in diabetes and hypertension: cross talk in RAS, BMP4, and ROS-dependent COX-2-derived prostanoids.	ros	83-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
23232839-0	2013	Endothelial dysfunction in diabetes and hypertension: cross talk in RAS, BMP4, and ROS-dependent COX-2-derived prostanoids.	Prostaglandins	111-122	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
23357750-4	2013	In the interference study, Co(II) was selectivity extracted in the top phase in the presence of Ni(II) and Cd(II) in a concentration of up to 20 times the cobalt level in the system.	cd(ii)	107-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-33
23357750-4	2013	In the interference study, Co(II) was selectivity extracted in the top phase in the presence of Ni(II) and Cd(II) in a concentration of up to 20 times the cobalt level in the system.	Cobalt	155-161	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-33
22121107-1	2013	Prostaglandin E2 (PGE2) is an important pro-angiogenic and pro-proliferative cytokine and the key enzymes modulating its levels, cyclooxygenase (COX)-2 and 15-hydroxyprostaglandin dehydrogenase (15-PGDH) play important opposing roles in carcinogenesis.	Dinoprostone	0-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-151
23293373-5	2013	A cyclooxygenase (COX)-1 selective inhibitor enhanced, whereas a COX-2 selective or a dual COX-1/2 inhibitor attenuated adipogenesis induced by 20-HETE.	20-hydroxy-5,8,11,14-eicosatetraenoic acid	144-151	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-70
23293373-8	2013	Taken together we show for the first time that 20-HETE-derived COX-2-dependent 20-OH-PGE2 enhances mature inflamed adipocyte hypertrophy in MSC undergoing adipogenic differentiation.	20-hydroxy-5,8,11,14-eicosatetraenoic acid	47-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-68
23293373-8	2013	Taken together we show for the first time that 20-HETE-derived COX-2-dependent 20-OH-PGE2 enhances mature inflamed adipocyte hypertrophy in MSC undergoing adipogenic differentiation.	20-hydroxyprostaglandin E2	79-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-68
23356845-0	2013	Synthesis and characterisation of novel Co(II) complexes of pyrazole carboxylate derivated of sulfonamide as carbonic anhydrase inhibitors.	pyrazole carboxylate	60-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-46
23356845-0	2013	Synthesis and characterisation of novel Co(II) complexes of pyrazole carboxylate derivated of sulfonamide as carbonic anhydrase inhibitors.	Sulfonamides	94-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-46
22121107-7	2013	In this study, we identify a potentially adverse effect of HDACIs through induction of both 15-PGDH and COX-2 leading to elevated PGE2 levels and thereby stimulation of angiogenesis.	Dinoprostone	130-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
22121107-1	2013	Prostaglandin E2 (PGE2) is an important pro-angiogenic and pro-proliferative cytokine and the key enzymes modulating its levels, cyclooxygenase (COX)-2 and 15-hydroxyprostaglandin dehydrogenase (15-PGDH) play important opposing roles in carcinogenesis.	Dinoprostone	18-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-151
24237030-1	2013	The PGE2 pathway is important in inflammation-driven diseases and specific targeting of the inducible mPGES-1 is warranted due to the cardiovascular problems associated with the long-term use of COX-2 inhibitors.	Dinoprostone	4-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	195-200
23274253-0	2013	Characterization and biological studies on Co(II), Ni(II) and Cu(II) complexes of carbohydrazones ending by pyridyl ring.	carbohydrazones	82-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-49
23277181-5	2013	Cobalt olivine silicate (Co(2)SiO(4), Co II only) was clearly identified as the blue pigment in "Aranhoes" sample (2nd half of the 17th C.) - 824 cm(-1) band in the micro-Raman-spectrum.	cobalt olivine silicate	0-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-43
23274253-1	2013	The chelating behavior of ligands based on carbohydrazone core modified with pyridine end towards Co(II), Ni(II) and Cu(II) ions have been examined.	carbohydrazone	43-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-104
23277181-6	2013	Cobalt aluminate (CoAl(2)O(4), Co II only) is the blue pigment in the Wanli plate - 203 and 512 cm(-1) bands in the micro-Raman spectrum.	Cobalt aluminate	0-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-36
23274253-1	2013	The chelating behavior of ligands based on carbohydrazone core modified with pyridine end towards Co(II), Ni(II) and Cu(II) ions have been examined.	pyridine	77-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-104
23274253-6	2013	On the other hand, H(2)APEC acts as a mononegative tridentate in Co(II) complex, neutral tridentate in Ni(II) complex and neutral bidentate in Cu(II) complex.	h(2)	19-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-71
23343346-2	2013	The two-electron reduction of O(2) by 1,1"-dibromoferrocene (Br(2)Fc) was catalyzed by Co(II)(Ch), whereas virtually no reduction of O(2) occurred with Co(II)(OEP).	Oxygen	30-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-93
23243667-4	2013	The Me2Cyclen base is always involved in the coordination of the transition metal cation with the four amine functions; both side-arms bind Co(II) while only one of them binds Cu(II).	me2cyclen	4-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-146
23243667-4	2013	The Me2Cyclen base is always involved in the coordination of the transition metal cation with the four amine functions; both side-arms bind Co(II) while only one of them binds Cu(II).	Metals	76-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-146
23243667-4	2013	The Me2Cyclen base is always involved in the coordination of the transition metal cation with the four amine functions; both side-arms bind Co(II) while only one of them binds Cu(II).	Amines	103-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-146
23363008-10	2013	In addition, chicoric acid down regulated HO-1 and COX-2 via the PI3K/Akt pathway.	chicoric acid	13-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-56
23525414-9	2013	Expression of COX-2 (but not COX-1), mPGES-1, and macrophages was lower in the ASA group than in the control group.	Aspirin	79-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
23362992-1	2013	Flavone glucuronide isomers of five flavones (chrysin, apigenin, luteolin, baicalein, and scutellarein) were differentiated by collision-induced dissociation of [Co(II) (flavone-H) (4,7-diphenyl-1,10-phenanthroline)(2)](+) complexes.	flavone	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	162-168
23362992-1	2013	Flavone glucuronide isomers of five flavones (chrysin, apigenin, luteolin, baicalein, and scutellarein) were differentiated by collision-induced dissociation of [Co(II) (flavone-H) (4,7-diphenyl-1,10-phenanthroline)(2)](+) complexes.	Glucuronides	8-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	162-168
23362992-1	2013	Flavone glucuronide isomers of five flavones (chrysin, apigenin, luteolin, baicalein, and scutellarein) were differentiated by collision-induced dissociation of [Co(II) (flavone-H) (4,7-diphenyl-1,10-phenanthroline)(2)](+) complexes.	chrysin	46-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	162-168
23362992-1	2013	Flavone glucuronide isomers of five flavones (chrysin, apigenin, luteolin, baicalein, and scutellarein) were differentiated by collision-induced dissociation of [Co(II) (flavone-H) (4,7-diphenyl-1,10-phenanthroline)(2)](+) complexes.	scutellarein	90-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	162-168
23362992-1	2013	Flavone glucuronide isomers of five flavones (chrysin, apigenin, luteolin, baicalein, and scutellarein) were differentiated by collision-induced dissociation of [Co(II) (flavone-H) (4,7-diphenyl-1,10-phenanthroline)(2)](+) complexes.	flavone-h) (4,7-diphenyl-1,10-phenanthroline)	170-215	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	162-168
23343346-2	2013	The two-electron reduction of O(2) by 1,1"-dibromoferrocene (Br(2)Fc) was catalyzed by Co(II)(Ch), whereas virtually no reduction of O(2) occurred with Co(II)(OEP).	Oxygen	30-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-163
23343346-2	2013	The two-electron reduction of O(2) by 1,1"-dibromoferrocene (Br(2)Fc) was catalyzed by Co(II)(Ch), whereas virtually no reduction of O(2) occurred with Co(II)(OEP).	1,1"-dibromoferrocene	38-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-93
23343346-2	2013	The two-electron reduction of O(2) by 1,1"-dibromoferrocene (Br(2)Fc) was catalyzed by Co(II)(Ch), whereas virtually no reduction of O(2) occurred with Co(II)(OEP).	1,1"-dibromoferrocene	38-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-163
23343346-2	2013	The two-electron reduction of O(2) by 1,1"-dibromoferrocene (Br(2)Fc) was catalyzed by Co(II)(Ch), whereas virtually no reduction of O(2) occurred with Co(II)(OEP).	br(2)fc)	61-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-93
23343346-3	2013	In addition, Co(II)(Ch) is more stable than Co(II)(OEP), where the catalytic turnover number (TON) of the two-electron reduction of O(2) catalyzed by Co(II)(Ch) exceeded 30000.	Oxygen	132-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-19
23343346-3	2013	In addition, Co(II)(Ch) is more stable than Co(II)(OEP), where the catalytic turnover number (TON) of the two-electron reduction of O(2) catalyzed by Co(II)(Ch) exceeded 30000.	Oxygen	132-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-50
23343346-3	2013	In addition, Co(II)(Ch) is more stable than Co(II)(OEP), where the catalytic turnover number (TON) of the two-electron reduction of O(2) catalyzed by Co(II)(Ch) exceeded 30000.	Oxygen	132-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-54
23343346-3	2013	In addition, Co(II)(Ch) is more stable than Co(II)(OEP), where the catalytic turnover number (TON) of the two-electron reduction of O(2) catalyzed by Co(II)(Ch) exceeded 30000.	Oxygen	132-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-50
23343346-4	2013	The detailed kinetic studies have revealed that the rate-determining step in the catalytic cycle is the proton-coupled electron transfer reduction of O(2) with the protonated Co(II)(Ch) ([Co(II)(ChH)](+)) that is produced by facile electron-transfer reduction of [Co(III)(ChH)](2+) by ferrocene derivative in the presence of HClO(4).	Oxygen	150-154	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	175-185
23343346-4	2013	The detailed kinetic studies have revealed that the rate-determining step in the catalytic cycle is the proton-coupled electron transfer reduction of O(2) with the protonated Co(II)(Ch) ([Co(II)(ChH)](+)) that is produced by facile electron-transfer reduction of [Co(III)(ChH)](2+) by ferrocene derivative in the presence of HClO(4).	Oxygen	150-154	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	175-181
23343346-4	2013	The detailed kinetic studies have revealed that the rate-determining step in the catalytic cycle is the proton-coupled electron transfer reduction of O(2) with the protonated Co(II)(Ch) ([Co(II)(ChH)](+)) that is produced by facile electron-transfer reduction of [Co(III)(ChH)](2+) by ferrocene derivative in the presence of HClO(4).	co(iii)	264-271	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	175-185
23343346-4	2013	The detailed kinetic studies have revealed that the rate-determining step in the catalytic cycle is the proton-coupled electron transfer reduction of O(2) with the protonated Co(II)(Ch) ([Co(II)(ChH)](+)) that is produced by facile electron-transfer reduction of [Co(III)(ChH)](2+) by ferrocene derivative in the presence of HClO(4).	co(iii)	264-271	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	175-181
23343346-4	2013	The detailed kinetic studies have revealed that the rate-determining step in the catalytic cycle is the proton-coupled electron transfer reduction of O(2) with the protonated Co(II)(Ch) ([Co(II)(ChH)](+)) that is produced by facile electron-transfer reduction of [Co(III)(ChH)](2+) by ferrocene derivative in the presence of HClO(4).	ferrocene	285-294	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	175-185
23343346-4	2013	The detailed kinetic studies have revealed that the rate-determining step in the catalytic cycle is the proton-coupled electron transfer reduction of O(2) with the protonated Co(II)(Ch) ([Co(II)(ChH)](+)) that is produced by facile electron-transfer reduction of [Co(III)(ChH)](2+) by ferrocene derivative in the presence of HClO(4).	ferrocene	285-294	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	175-181
23343346-4	2013	The detailed kinetic studies have revealed that the rate-determining step in the catalytic cycle is the proton-coupled electron transfer reduction of O(2) with the protonated Co(II)(Ch) ([Co(II)(ChH)](+)) that is produced by facile electron-transfer reduction of [Co(III)(ChH)](2+) by ferrocene derivative in the presence of HClO(4).	Hypochlorous Acid	325-329	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	175-185
23343346-4	2013	The detailed kinetic studies have revealed that the rate-determining step in the catalytic cycle is the proton-coupled electron transfer reduction of O(2) with the protonated Co(II)(Ch) ([Co(II)(ChH)](+)) that is produced by facile electron-transfer reduction of [Co(III)(ChH)](2+) by ferrocene derivative in the presence of HClO(4).	Hypochlorous Acid	325-329	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	175-181
23343346-6	2013	Such a positive shift of [Co(III)(Ch)](+) by protonation resulted in enhancement of the catalytic reactivity of [Co(III)(ChH)](2+) for the two-electron reduction of O(2) with a lower overpotential as compared with that of [Co(III)(OEP)](+).	co(iii)	26-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	231-234
23343346-6	2013	Such a positive shift of [Co(III)(Ch)](+) by protonation resulted in enhancement of the catalytic reactivity of [Co(III)(ChH)](2+) for the two-electron reduction of O(2) with a lower overpotential as compared with that of [Co(III)(OEP)](+).	co(iii)	113-120	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	231-234
23343346-6	2013	Such a positive shift of [Co(III)(Ch)](+) by protonation resulted in enhancement of the catalytic reactivity of [Co(III)(ChH)](2+) for the two-electron reduction of O(2) with a lower overpotential as compared with that of [Co(III)(OEP)](+).	Oxygen	165-169	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	231-234
23343346-6	2013	Such a positive shift of [Co(III)(Ch)](+) by protonation resulted in enhancement of the catalytic reactivity of [Co(III)(ChH)](2+) for the two-electron reduction of O(2) with a lower overpotential as compared with that of [Co(III)(OEP)](+).	co(iii)	113-120	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	231-234
23414519-2	2013	METHODOLOGY: Immunohistochemical expression of COX2 and iNOS was assessed in formalin fixed paraffin wax processed tissues obtained from 155 patients with bladder cancers (87 SCC and 68 TCC) and 39 patients with benign bladder cystitis.	Formaldehyde	77-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-51
23414519-2	2013	METHODOLOGY: Immunohistochemical expression of COX2 and iNOS was assessed in formalin fixed paraffin wax processed tissues obtained from 155 patients with bladder cancers (87 SCC and 68 TCC) and 39 patients with benign bladder cystitis.	Paraffin	92-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-51
23160418-0	2013	Computational design of valence tautomeric adducts of Co(II) diketonates with redox-active o-benzoquinone ligands.	2-benzoquinone	91-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-59
23402310-1	2013	BACKGROUND: Celecoxib is a selective cyclooxygenase (COX)-2 inhibitor that has been reported to reduce the risk of breast cancer.	Celecoxib	12-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-59
23394575-8	2013	CONCLUSIONS: These data suggest aATC can suppress MDSC differentiation and attenuation of their suppressive activity through down regulation of COX2, PGE2 and ARG1 pathway that is potentiated in presence of Th1 cytokines, suggesting that Th1 enriching immunotherapy may be beneficial in pancreatic cancer treatment.	aatc	32-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	144-148
23266605-3	2013	The metal complexes with Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II) and Th(IV) have been prepared and characterized by elemental analyses, IR and (1)H-NMR spectroscopy, thermal and magnetic measurements.	Metals	4-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-57
23322198-0	2013	Cox-2 inhibition enhances the activity of sunitinib in human renal cell carcinoma xenografts.	Sunitinib	42-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
23165737-0	2013	Bipyridine and phenanthroline IR-spectral bands as indicators of metal spin state in hexacoordinated complexes of Fe(II), Ni(II) and Co(II).	2,2'-Dipyridyl	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	133-139
23165737-0	2013	Bipyridine and phenanthroline IR-spectral bands as indicators of metal spin state in hexacoordinated complexes of Fe(II), Ni(II) and Co(II).	Phenanthrolines	15-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	133-139
23165737-0	2013	Bipyridine and phenanthroline IR-spectral bands as indicators of metal spin state in hexacoordinated complexes of Fe(II), Ni(II) and Co(II).	Metals	65-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	133-139
23165737-0	2013	Bipyridine and phenanthroline IR-spectral bands as indicators of metal spin state in hexacoordinated complexes of Fe(II), Ni(II) and Co(II).	ammonium ferrous sulfate	114-120	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	133-139
23165737-5	2013	Found spectral markers have been validated at a number of complexes of Fe(II), Ni(II), Co(II), Zn(II) and Cu(II) with bpy and phen ligands.	ammonium ferrous sulfate	71-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-93
23165737-5	2013	Found spectral markers have been validated at a number of complexes of Fe(II), Ni(II), Co(II), Zn(II) and Cu(II) with bpy and phen ligands.	2,2'-Dipyridyl	118-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-93
23172152-0	2013	An alpha-Keggin polyoxometalate completely constructed from the late transition metal Co(II) as poly atom.	poly	16-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-92
23172152-1	2013	We report a catalytic eight-cobalt-capped alpha-Keggin polyoxoazocobaltite with a highly symmetric structure completely constructed from the late transition-metal Co(II) as a poly atom, [Co(20)(OH)(24)(MMT)(12)(SO(4))](NO(3))(2) 6H(2)O (1) (MMT: 2-mercapto-5-methyl-1,3,4-thiadiazole).	Cobalt	28-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	163-168
23172152-1	2013	We report a catalytic eight-cobalt-capped alpha-Keggin polyoxoazocobaltite with a highly symmetric structure completely constructed from the late transition-metal Co(II) as a poly atom, [Co(20)(OH)(24)(MMT)(12)(SO(4))](NO(3))(2) 6H(2)O (1) (MMT: 2-mercapto-5-methyl-1,3,4-thiadiazole).	alpha-keggin	42-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	163-168
23322198-11	2013	Clinical trials combining Su and COX-2 inhibitors should be considered as a means delaying time to progression on sunitinib in patients with metastatic cRCC.	Sunitinib	114-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-38
23172152-1	2013	We report a catalytic eight-cobalt-capped alpha-Keggin polyoxoazocobaltite with a highly symmetric structure completely constructed from the late transition-metal Co(II) as a poly atom, [Co(20)(OH)(24)(MMT)(12)(SO(4))](NO(3))(2) 6H(2)O (1) (MMT: 2-mercapto-5-methyl-1,3,4-thiadiazole).	polyoxoazocobaltite	55-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	163-168
23424399-2	2013	The unique Co(II) ion is coordinated in a slightly distorted octa-hedral coordination geometry by two O atoms from a chelating 4-(carb-oxy-phen-oxy)phthalate ligand, three water O atoms and a further O atom from a bridging carboxyl-ate group of a symmetry-related 4-(carb-oxy-phen-oxy)phthalate ligand.	4-(carb-oxy-phen-oxy)phthalate	127-157	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-17
23172152-1	2013	We report a catalytic eight-cobalt-capped alpha-Keggin polyoxoazocobaltite with a highly symmetric structure completely constructed from the late transition-metal Co(II) as a poly atom, [Co(20)(OH)(24)(MMT)(12)(SO(4))](NO(3))(2) 6H(2)O (1) (MMT: 2-mercapto-5-methyl-1,3,4-thiadiazole).	Metals	157-162	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	163-168
23172152-1	2013	We report a catalytic eight-cobalt-capped alpha-Keggin polyoxoazocobaltite with a highly symmetric structure completely constructed from the late transition-metal Co(II) as a poly atom, [Co(20)(OH)(24)(MMT)(12)(SO(4))](NO(3))(2) 6H(2)O (1) (MMT: 2-mercapto-5-methyl-1,3,4-thiadiazole).	poly	55-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	163-168
23172152-1	2013	We report a catalytic eight-cobalt-capped alpha-Keggin polyoxoazocobaltite with a highly symmetric structure completely constructed from the late transition-metal Co(II) as a poly atom, [Co(20)(OH)(24)(MMT)(12)(SO(4))](NO(3))(2) 6H(2)O (1) (MMT: 2-mercapto-5-methyl-1,3,4-thiadiazole).	co(20)	187-193	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	163-168
23172152-1	2013	We report a catalytic eight-cobalt-capped alpha-Keggin polyoxoazocobaltite with a highly symmetric structure completely constructed from the late transition-metal Co(II) as a poly atom, [Co(20)(OH)(24)(MMT)(12)(SO(4))](NO(3))(2) 6H(2)O (1) (MMT: 2-mercapto-5-methyl-1,3,4-thiadiazole).	so(4))	211-217	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	163-168
23172152-1	2013	We report a catalytic eight-cobalt-capped alpha-Keggin polyoxoazocobaltite with a highly symmetric structure completely constructed from the late transition-metal Co(II) as a poly atom, [Co(20)(OH)(24)(MMT)(12)(SO(4))](NO(3))(2) 6H(2)O (1) (MMT: 2-mercapto-5-methyl-1,3,4-thiadiazole).	no(3))(2) 6h	219-231	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	163-168
23172152-1	2013	We report a catalytic eight-cobalt-capped alpha-Keggin polyoxoazocobaltite with a highly symmetric structure completely constructed from the late transition-metal Co(II) as a poly atom, [Co(20)(OH)(24)(MMT)(12)(SO(4))](NO(3))(2) 6H(2)O (1) (MMT: 2-mercapto-5-methyl-1,3,4-thiadiazole).	2-methyl-1,3,4-thiadiazole-5-thiol	246-283	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	163-168
23317083-1	2013	The 5,10,15,20-tetraphenyl-21-oxaporphyrin complexes of Mn(II), Co(II), and Zn(II) have been crystallized and studied by X-ray diffraction, NMR and UV/vis spectroscopy, and mass spectrometry as well as cyclic voltammetry.	5,10,15,20-tetraphenyl-21-oxaporphyrin	4-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-69
23317083-6	2013	Cyclic voltammetry studies reveal that the reduction of the complex bound Mn(II), Co(II), and Zn(II) ions is a ligand-centered process whereas the first oxidation step depends on the metal ion present.	Manganese(2+)	74-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
23317083-6	2013	Cyclic voltammetry studies reveal that the reduction of the complex bound Mn(II), Co(II), and Zn(II) ions is a ligand-centered process whereas the first oxidation step depends on the metal ion present.	Metals	183-188	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
23424399-2	2013	The unique Co(II) ion is coordinated in a slightly distorted octa-hedral coordination geometry by two O atoms from a chelating 4-(carb-oxy-phen-oxy)phthalate ligand, three water O atoms and a further O atom from a bridging carboxyl-ate group of a symmetry-related 4-(carb-oxy-phen-oxy)phthalate ligand.	water o	172-179	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-17
23424399-2	2013	The unique Co(II) ion is coordinated in a slightly distorted octa-hedral coordination geometry by two O atoms from a chelating 4-(carb-oxy-phen-oxy)phthalate ligand, three water O atoms and a further O atom from a bridging carboxyl-ate group of a symmetry-related 4-(carb-oxy-phen-oxy)phthalate ligand.	carboxyl-ate	223-235	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-17
23424399-2	2013	The unique Co(II) ion is coordinated in a slightly distorted octa-hedral coordination geometry by two O atoms from a chelating 4-(carb-oxy-phen-oxy)phthalate ligand, three water O atoms and a further O atom from a bridging carboxyl-ate group of a symmetry-related 4-(carb-oxy-phen-oxy)phthalate ligand.	4-(carb-oxy-phen-oxy)phthalate	264-294	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-17
23424401-1	2013	In the title compound, [Co(H(2)O)(6)](C(14)H(10)O(6)) 2H(2)O, the 2,2"-[naphthalene-1,8-diylbis(-oxy)]diacetate dianion L is not coordinated to the Co(II) ion.	co(h(2)o)(6)	24-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	148-154
23424401-1	2013	In the title compound, [Co(H(2)O)(6)](C(14)H(10)O(6)) 2H(2)O, the 2,2"-[naphthalene-1,8-diylbis(-oxy)]diacetate dianion L is not coordinated to the Co(II) ion.	2h(2)o	54-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	148-154
22923191-5	2013	Large amounts of COX-2-derived prostaglandin (PG)E(2) were secreted from LPS-stimulated A549 cells.	Prostaglandins E	31-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22
23023196-0	2013	Promoter scanning of the human COX-2 gene with 8-ring polyamides: unexpected weakening of polyamide-DNA binding and selectivity by replacing an internal N-Me-pyrrole with beta-alanine.	Nylons	54-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-36
23023196-0	2013	Promoter scanning of the human COX-2 gene with 8-ring polyamides: unexpected weakening of polyamide-DNA binding and selectivity by replacing an internal N-Me-pyrrole with beta-alanine.	Nylons	54-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-36
23023196-0	2013	Promoter scanning of the human COX-2 gene with 8-ring polyamides: unexpected weakening of polyamide-DNA binding and selectivity by replacing an internal N-Me-pyrrole with beta-alanine.	n-me-pyrrole	153-165	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-36
23023196-0	2013	Promoter scanning of the human COX-2 gene with 8-ring polyamides: unexpected weakening of polyamide-DNA binding and selectivity by replacing an internal N-Me-pyrrole with beta-alanine.	beta-Alanine	171-183	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-36
22923191-8	2013	Inhibition of COX-2 activity in A549 cells severely attenuated both PGE(2) release and proliferation in response to LPS.	Dinoprostone	68-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
23362950-4	2013	IL-6 and COX-2 were decreased by the free bile acids and increased by the conjugated bile acids.	Bile Acids and Salts	42-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	9-14
23245395-2	2013	The aim of the present study was to investigate the effect of celecoxib, a COX-2 inhibitor, on CD133 expression in HT29 and DLD1 cells.	Celecoxib	62-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
23179791-0	2013	Role of LOXs and COX-2 on FAK activation and cell migration induced by linoleic acid in MDA-MB-231 breast cancer cells.	Linoleic Acid	71-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22
23362950-4	2013	IL-6 and COX-2 were decreased by the free bile acids and increased by the conjugated bile acids.	Bile Acids and Salts	85-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	9-14
23256547-0	2013	Mitochondrial COX2 G7598A mutation may have a modifying role in the phenotypic manifestation of aminoglycoside antibiotic-induced deafness associated with 12S rRNA A1555G mutation in a Han Chinese pedigree.	Aminoglycosides	96-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-18
22812394-3	2013	In this study, we prepared a group of Co(II)-pbzim complexes that bear variable numbers of both positive charges and benzimidazole (bzim) groups.	benzimidazole	117-130	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-44
22812394-3	2013	In this study, we prepared a group of Co(II)-pbzim complexes that bear variable numbers of both positive charges and benzimidazole (bzim) groups.	benzimidazole	46-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-44
22812394-9	2013	The MTT data indicated that cytotoxicity of both Co(II) complexes and condensates is enhanced with increasing positive charges and bzim groups.	monooxyethylene trimethylolpropane tristearate	4-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-55
23256547-8	2013	Phylogenetic analysis of COX2 polypeptide sequences demonstrates that the alanine residue is relatively conserved, but owing to the missense mutation (p.Ala 5 Thr), its side chain hydrophobicity will be changed, and what is more, as it is adjacent to a glutamine residue, which is highly conserved and hydrophilic, in an evolutionary stable domain; G7598A (p.Ala 5 Thr) may alter the protein secondary structure and physiological function of COX2 and, thus, aggravate the mitochondrial dysfunction conferred by the A1555G mutation.	Alanine	74-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-29
23256547-8	2013	Phylogenetic analysis of COX2 polypeptide sequences demonstrates that the alanine residue is relatively conserved, but owing to the missense mutation (p.Ala 5 Thr), its side chain hydrophobicity will be changed, and what is more, as it is adjacent to a glutamine residue, which is highly conserved and hydrophilic, in an evolutionary stable domain; G7598A (p.Ala 5 Thr) may alter the protein secondary structure and physiological function of COX2 and, thus, aggravate the mitochondrial dysfunction conferred by the A1555G mutation.	Alanine	74-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	442-446
23256547-8	2013	Phylogenetic analysis of COX2 polypeptide sequences demonstrates that the alanine residue is relatively conserved, but owing to the missense mutation (p.Ala 5 Thr), its side chain hydrophobicity will be changed, and what is more, as it is adjacent to a glutamine residue, which is highly conserved and hydrophilic, in an evolutionary stable domain; G7598A (p.Ala 5 Thr) may alter the protein secondary structure and physiological function of COX2 and, thus, aggravate the mitochondrial dysfunction conferred by the A1555G mutation.	Glutamine	253-262	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-29
23244055-7	2013	The results suggest that sulfite is rapidly autoxidized in the presence of Co(II), Cu(II), Cr(VI), Fe(III), and Mn(II), producing radicals that cause the DNA damage.	Sulfites	25-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-81
23190385-6	2013	CsA decreased whole-blood COX-2 activity by 39% (P = 0.05) and basal plasma 6-keto-PGF(1alpha)  levels by 31%, only nonsignificantly.	Cyclosporine	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-31
23190385-13	2013	CsA suppresses COX-2 activity, while Tac decreases platelet activity.	Cyclosporine	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-20
23343191-8	2013	Furthermore, doxorubicin alone greatly induced COX-2, a NF-kappaB target and Cdk-1, a target of P276-00, which was downregulated by P276-00 in the combination.	Doxorubicin	13-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
23137061-8	2013	Compared to the passage-matched control, chronic arsenic exposure caused exposure-duration dependent increases in secreted MMP-2 and MMP-9 activity, Cox-2 expression, and more rapid proliferation (all &gt;2-fold), characteristics typical of cancer cells.	Arsenic	49-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	149-154
23441769-1	2013	BACKGROUND: Cyclo-oxygenase (COX)-2 inhibitors have been the target of severe criticism, more so following the withdrawal of Rofecoxib.	rofecoxib	125-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-35
23153451-8	2013	In addition, these fatty acids altered expression of several lipid metabolic genes such as ADRP, FABP4, FABP3, and COX-2 those are involved in angiogenesis.	Fatty Acids	19-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-120
23268743-5	2013	In the TNF-alpha-induced 3T3-L1 adipocyte model, garcinol and pterostilbene significantly decreased the mRNA expression of COX-2, iNOS, IL-6, and IL-1beta and IL-6 secretion by suppressing phosphorylation of p-IkappaBalpha and p-p65.	garcinol	49-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-128
23268743-5	2013	In the TNF-alpha-induced 3T3-L1 adipocyte model, garcinol and pterostilbene significantly decreased the mRNA expression of COX-2, iNOS, IL-6, and IL-1beta and IL-6 secretion by suppressing phosphorylation of p-IkappaBalpha and p-p65.	pterostilbene	62-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-128
23268743-7	2013	In the RAW 264.7 macrophage-derived conditioned medium (RAW-CM)-induced 3T3-L1 adipocyte and 3T3-CM-induced RAW 264.7 macrophage models, pterostilbene significantly decreased IL-6 and TNF-alpha secretion and proinflammatory mRNA expression (COX-2, iNOS, IL-6, TNF-alpha, PAI-1, CRP, MCP-1, resistin, and leptin).	pterostilbene	137-150	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	241-246
23223191-6	2013	The radiolytic oxidation of Co(II) to Co(III) was completed in 100 min and the chemical composition of the final particles was identified as Co(3)O(4) by XPS, Raman and UV-Vis spectroscopy.	co(3)o(4)	141-150	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-34
23276282-1	2013	Reaction of iron(II) thiocyanate with an excess of trans-1,2-bis(4-pyridyl)-ethylene (bpe) in acetonitrile at room temperature leads to the formation of [Fe(NCS)(2)(bpe)(2) (bpe)] (1), which is isotypic to its Co(II) analogue.	ferrous thiocyanate	12-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	210-216
23276282-1	2013	Reaction of iron(II) thiocyanate with an excess of trans-1,2-bis(4-pyridyl)-ethylene (bpe) in acetonitrile at room temperature leads to the formation of [Fe(NCS)(2)(bpe)(2) (bpe)] (1), which is isotypic to its Co(II) analogue.	trans-1,2-bis(4-pyridyl)-ethylene	51-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	210-216
23276282-1	2013	Reaction of iron(II) thiocyanate with an excess of trans-1,2-bis(4-pyridyl)-ethylene (bpe) in acetonitrile at room temperature leads to the formation of [Fe(NCS)(2)(bpe)(2) (bpe)] (1), which is isotypic to its Co(II) analogue.	1,2-bis(4-pyridyl)ethene	86-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	210-216
23276282-1	2013	Reaction of iron(II) thiocyanate with an excess of trans-1,2-bis(4-pyridyl)-ethylene (bpe) in acetonitrile at room temperature leads to the formation of [Fe(NCS)(2)(bpe)(2) (bpe)] (1), which is isotypic to its Co(II) analogue.	acetonitrile	94-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	210-216
23276282-1	2013	Reaction of iron(II) thiocyanate with an excess of trans-1,2-bis(4-pyridyl)-ethylene (bpe) in acetonitrile at room temperature leads to the formation of [Fe(NCS)(2)(bpe)(2) (bpe)] (1), which is isotypic to its Co(II) analogue.	fe(ncs)	154-161	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	210-216
23244055-8	2013	These radicals can be ranked in a descending order of their ability to induce DNA damage with sulfite as follows: Fe(III) &gt; Co(II) &gt; Cu(II) &gt; Cr(VI) &gt; Mn(II).	Sulfites	94-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	127-133
23244055-9	2013	The DNA damage induced by sulfite plus Co(II), Cr(VI), and Fe(III) was inhibited by primary alcohols, but they were not when superoxide dismutase (SOD) and tert-butyl alcohol were used.	Alcohols	92-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-45
23292931-0	2013	COX-2, the dominant source of prostacyclin.	Epoprostenol	30-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
24289600-9	2013	Thus reduced miR-101 expression could participate in the development of cervical cancer at least partly through loss of inhibition of target gene COX-2, which probably occurs in a relative late phase of carcinogenesis.	mir-101	13-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	146-151
23180690-3	2013	The negative D value, and hence an easy axis of magnetization, found for the Ni(II) complex indicates stabilization of the highest M(S) value of the S = 1 ground spin state, while a large and positive D value, and hence an easy plane of magnetization, found for Co(II) indicates stabilization of the M(S) = +-1/2 sublevels of the S = 3/2 spin state.	Nickel(2+)	77-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	262-268
23306154-7	2013	In addition, the medicinal effect of the Si-QDs (i.e., the inhibition of COX-2 enzyme) was maintained compared to that of the original drug.	Silicon	41-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-78
23289871-0	2013	Inhibition of COX-2 expression by topical diclofenac enhanced radiation sensitivity via enhancement of TRAIL in human prostate adenocarcinoma xenograft model.	Diclofenac	42-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
23289871-3	2013	In this study, we tested if topical diclofenac, which inhibits both COX-1 and COX-2, administration rendered prostate tumor cells sensitize to the effects of radiation.	Diclofenac	36-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-83
23289871-7	2013	In addition, we assessed the tumor volumes of xenograft LNCaP-COX-2 cells treated with topical diclofenac with or without radiation therapy (RT).	Diclofenac	95-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
23289871-8	2013	RESULTS: LNCaP-COX-2 and LNCaP-Neo cell lines experienced cytotoxic effects of diclofenac in a dose related manner.	Diclofenac	79-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-20
23289871-10	2013	Furthermore, the addition of diclofenac sensitized LNCaP-COX-2 not but LNCaP-Neo cells to the cytocidal effects of radiation.	Diclofenac	29-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-62
23289871-11	2013	In LNCaP-COX-2 cells, diclofenac enhanced radiation-induced apoptosis compared with RT alone.	Diclofenac	22-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	9-14
23289871-14	2013	CONCLUSIONS: These in vitro and in vivo findings suggest that conventional COX inhibitor, diclofenac enhances the effect of RT on prostate cancer cells that express COX-2.	Diclofenac	90-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	165-170
23749135-5	2013	The metal ions were extracted through complexation with 8-hydroxyquinoline in the organic-rich phase with distribution constants and extraction percentage values, respectively, of 0.47 and 74 for Fe(III), 0.15 and 47 for Co(II), and 0.08 and 32 for Ni(II).	Metals	4-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	221-226
23749135-5	2013	The metal ions were extracted through complexation with 8-hydroxyquinoline in the organic-rich phase with distribution constants and extraction percentage values, respectively, of 0.47 and 74 for Fe(III), 0.15 and 47 for Co(II), and 0.08 and 32 for Ni(II).	Oxyquinoline	56-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	221-226
23737767-5	2013	In particular, clinically relevant DDIs have been described during the treatment with MTX and NSAIDs, for example, diclofenac, indomethacin, or COX-2 inhibitors, and between MTX and prednisone or immunosuppressant drugs (e.g., leflunomide and cyclosporine).	Methotrexate	86-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	144-149
23737767-5	2013	In particular, clinically relevant DDIs have been described during the treatment with MTX and NSAIDs, for example, diclofenac, indomethacin, or COX-2 inhibitors, and between MTX and prednisone or immunosuppressant drugs (e.g., leflunomide and cyclosporine).	Methotrexate	174-177	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	144-149
23737767-5	2013	In particular, clinically relevant DDIs have been described during the treatment with MTX and NSAIDs, for example, diclofenac, indomethacin, or COX-2 inhibitors, and between MTX and prednisone or immunosuppressant drugs (e.g., leflunomide and cyclosporine).	Prednisone	182-192	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	144-149
23737767-5	2013	In particular, clinically relevant DDIs have been described during the treatment with MTX and NSAIDs, for example, diclofenac, indomethacin, or COX-2 inhibitors, and between MTX and prednisone or immunosuppressant drugs (e.g., leflunomide and cyclosporine).	Leflunomide	227-238	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	144-149
23737767-5	2013	In particular, clinically relevant DDIs have been described during the treatment with MTX and NSAIDs, for example, diclofenac, indomethacin, or COX-2 inhibitors, and between MTX and prednisone or immunosuppressant drugs (e.g., leflunomide and cyclosporine).	Cyclosporine	243-255	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	144-149
23218602-4	2013	1-[2-(N-Phenylbenzenesulfonamido)ethyl]-1H-1,2,3-triazole-4,5-dicarboxylic acid (6f) inhibits human mPGES-1 (IC(50) of 1.1 muM) with high selectivity (ca.1000-fold) over both COX-1 and COX-2 in a cell-free assay.	1-[2-(n-phenylbenzenesulfonamido)ethyl]-1h	0-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	185-190
24453995-1	2013	A series of new di-, tri-, and tetranuclear Co(II) and Cu(II) complexes of three new diSchiff base ligands were synthesized by two different methods.	dischiff base	85-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-50
23546287-7	2013	CPC also inhibited RANKL-induced activation of extracellular signal-regulated kinase (ERK) and NF-kappaB and expression of cyclooxygenase (COX)-2.	Cetylpyridinium	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-145
23546287-8	2013	These results collectively suggest that CPC inhibits osteoclast differentiation by suppressing the activation of ERK and NF-kappaB and reducing the expression of COX-2, c-Fos, and NFATc1.	Cetylpyridinium	40-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	162-167
23762835-6	2013	Increased gene expression was confirmed by collagen degradation assays and immunocytochemistry of prostaglandin 2, a product of COX2 activity.	(5Z,13E,15S)-15-hydroxy-9-oxoprosta-5,10,13-trien-1-oate	98-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	128-132
23218602-4	2013	1-[2-(N-Phenylbenzenesulfonamido)ethyl]-1H-1,2,3-triazole-4,5-dicarboxylic acid (6f) inhibits human mPGES-1 (IC(50) of 1.1 muM) with high selectivity (ca.1000-fold) over both COX-1 and COX-2 in a cell-free assay.	1H-1,2,3-Triazole-4,5-dicarboxylic acid	43-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	185-190
23530507-9	2013	An additional flow cytometry study demonstrated increased intracellular accumulation of DiBAC4(3) in K562 leukemic cells that overexpress MDR-1 and COX-2 genes, and are refractory to specific cytotoxic agents.	bis(1,3-dibutylbarbiturate)trimethine oxonol	88-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	148-153
23167625-0	2013	Selective COX-2 inhibitor (celecoxib) decreases cellular growth in prostate cancer cell lines independent of p53.	Celecoxib	27-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
23167625-1	2013	Celecoxib is a clinically available COX-2 inhibitor that has been reported to have antineoplastic activity.	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-41
23010081-1	2013	The COX-2 inhibitor Celecoxib, tested in phase III trials for the prevention of sporadic colon adenomas, reduced the appearance of new adenomas, but was unable to affect the incidence of colon cancer.	Celecoxib	20-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
23149922-2	2013	In this study, we identified migration inducting gene-7 (MIG-7) protein as critical for COX-2/prostaglandin E2 (PGE2)- and Akt/GSK-3beta-dependent tumor invasion/metastasis.	Dinoprostone	94-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-93
23149922-2	2013	In this study, we identified migration inducting gene-7 (MIG-7) protein as critical for COX-2/prostaglandin E2 (PGE2)- and Akt/GSK-3beta-dependent tumor invasion/metastasis.	Dinoprostone	112-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-93
23149922-3	2013	COX-2/PGE2 activated EP4 to enhance Akt and GSK-3beta phosphorylation and beta-catenin/T-cell factor/lymphoid enhancer factor signaling leading to MIG-7 upregulation.	Dinoprostone	6-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
23149922-4	2013	RNAi-mediated attenuation of MIG-7 blocked COX-2/PGE2- and Akt/GSK-3beta-mediated migration/invasion effects.	Dinoprostone	49-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
23149922-8	2013	MIG-7 thus offers a theranostic target for cancer metastases arising from aberrant activation of the cellular COX-2/PGE2 and Akt/GSK-3beta signaling pathways.	Dinoprostone	116-120	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-115
23812396-1	2013	N-Carbethoxymethyl-1,10-phenanthrolinium bromide (CempBr) and its five ionic metal complexes, [Cemp]2[MCl4] where M = Cu(II) (1), Zn(II) (2), Co(II) (3), Ni(II) (4) and Mn(II) (5) were synthesized and fully characterized.	n-carbethoxymethyl-1,10-phenanthrolinium bromide	0-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	142-148
23812396-1	2013	N-Carbethoxymethyl-1,10-phenanthrolinium bromide (CempBr) and its five ionic metal complexes, [Cemp]2[MCl4] where M = Cu(II) (1), Zn(II) (2), Co(II) (3), Ni(II) (4) and Mn(II) (5) were synthesized and fully characterized.	cempbr	50-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	142-148
23869610-6	2013	Experiments were performed in the presence and absence of titanium particles, SP and NS-398 (a selective COX-2 inhibitor).	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	85-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-110
23869610-7	2013	Titanium particles or SP stimulated RANKL and COX-2 expression in fibroblasts, whereas NS-398 inhibited RANKL production, suggesting a COX-2-mediated event.	Titanium	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
23869610-7	2013	Titanium particles or SP stimulated RANKL and COX-2 expression in fibroblasts, whereas NS-398 inhibited RANKL production, suggesting a COX-2-mediated event.	Titanium	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-140
23869610-8	2013	Moreover, SP enhanced COX-2 and RANKL expression by titanium particles-stimulated fibroblasts.	Titanium	52-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-27
23167625-12	2013	Reduced COX-2 expression was found with decreased p53 in LNCaP and PC-3 cells that were exposed to &gt;= 20 muM of celecoxib for 72 h, but COX-2 expression was increased in DU145 cells.	Celecoxib	115-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	8-13
23800656-4	2013	Tumor cell death was evaluated by fluorescence microscopy and flow cytometry for the Sn(IV) compound and also for a Co(II) compound bearing 1,10-phenanthroline-5,6-dione as ligand.	1,10-phenanthroline-5,6-dione	140-169	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-122
23401648-2	2013	As the protective effect of aspirin has been associated with an increased expression of COX-2, molecular imaging of COX-2, for instance, during confocal endomicroscopy could enable the identification of patients who would possibly benefit from aspirin treatment.	Aspirin	28-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-93
23401648-2	2013	As the protective effect of aspirin has been associated with an increased expression of COX-2, molecular imaging of COX-2, for instance, during confocal endomicroscopy could enable the identification of patients who would possibly benefit from aspirin treatment.	Aspirin	28-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-121
23401648-2	2013	As the protective effect of aspirin has been associated with an increased expression of COX-2, molecular imaging of COX-2, for instance, during confocal endomicroscopy could enable the identification of patients who would possibly benefit from aspirin treatment.	Aspirin	244-251	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-93
23401648-2	2013	As the protective effect of aspirin has been associated with an increased expression of COX-2, molecular imaging of COX-2, for instance, during confocal endomicroscopy could enable the identification of patients who would possibly benefit from aspirin treatment.	Aspirin	244-251	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-121
24191167-6	2013	We found that COX-2/PGE2 signaling pathway, which plays key roles in the development of cancer, is involved in the antitumor activities of these saponins.	Dinoprostone	20-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
22392616-0	2013	Fast simultaneous determination of traces of Cu(II) and Co(II) in soils and sediments with the luminol/perborate chemiluminescent system.	Luminol	95-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-62
22392616-0	2013	Fast simultaneous determination of traces of Cu(II) and Co(II) in soils and sediments with the luminol/perborate chemiluminescent system.	perborate	103-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-62
24191167-7	2013	These data provide the evidence that triterpenoid saponins can induce apoptosis via COX-2/PGE2 pathway, implying a preventive role of saponins from Anemone flaccida in tumor.	Saponins	134-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-89
22989703-6	2013	Both apo-lycopenoic acids also decreased CSE-induced ROS production, 8-OHdG formation and reduced the increase in NOX-4 and COX-2 expressions caused by CSE.	apo-lycopenoic acids	5-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	124-129
23163543-10	2013	Ex vivo inhibition of COX-1 (thromboxane A(2)) and COX-2 (PGE(2)) at the plasma concentrations of S(+)-ibuprofen corresponding to those found in the plasma following ingestion of 400 mg ibuprofen in dental and other inflammatory pain models provides evidence of the anti-inflammatory mechanism at OTC dosages.	Prostaglandins E	58-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-56
23163543-10	2013	Ex vivo inhibition of COX-1 (thromboxane A(2)) and COX-2 (PGE(2)) at the plasma concentrations of S(+)-ibuprofen corresponding to those found in the plasma following ingestion of 400 mg ibuprofen in dental and other inflammatory pain models provides evidence of the anti-inflammatory mechanism at OTC dosages.	Ibuprofen	98-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-56
23964558-2	2013	OBJECTIVE: To evaluate tolerability to etoricoxib, a second-generation COX-2 inhibitor with high in vitro selectivity for COX-2 in patients with AERD.	Etoricoxib	39-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-76
23964558-2	2013	OBJECTIVE: To evaluate tolerability to etoricoxib, a second-generation COX-2 inhibitor with high in vitro selectivity for COX-2 in patients with AERD.	Etoricoxib	39-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-127
23964558-7	2013	CONCLUSIONS: The highly selective COX-2 inhibitor etoricoxib was tolerated in most but not all patients tested.	Etoricoxib	50-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-39
23646722-2	2013	Herein, nearly monodisperse CoFe2O4 nanoparticles have been deposited on multi-walled carbon nanotubes (MWCNTs) by high-temperature hydrolysis and inorganic polymerization of ionic Co(II) and Fe(III) salts and MWCNTs in a polyol solution.	cobalt ferrite	28-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	181-187
23646722-2	2013	Herein, nearly monodisperse CoFe2O4 nanoparticles have been deposited on multi-walled carbon nanotubes (MWCNTs) by high-temperature hydrolysis and inorganic polymerization of ionic Co(II) and Fe(III) salts and MWCNTs in a polyol solution.	mwcnts	104-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	181-187
23112250-0	2013	Simultaneous targeting of COX-2 and AKT using selenocoxib-1-GSH to inhibit melanoma.	2-amino-4-(1-(carboxymethylcarbamoyl)-2-(5-phenyl-1-(4-sulfamoylphenyl)-1H-pyrazol-3-yl)methylselanylthiol-ethylcarbamoyl)butryic acid	46-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-31
23112250-6	2013	Selenocoxib-1-GSH reduced development of xenografted tumor by approximately 70% with negligible toxicity by targeting COX-2, like celecoxib, and having novel inhibitory properties by acting as a PI3K/Akt inhibitor (and MAPK pathway activator to inhibitory levels due to Akt inhibition).	2-amino-4-(1-(carboxymethylcarbamoyl)-2-(5-phenyl-1-(4-sulfamoylphenyl)-1H-pyrazol-3-yl)methylselanylthiol-ethylcarbamoyl)butryic acid	0-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-123
23112250-8	2013	Thus, this study details the development of selenocoxib-1-GSH, which is a nontoxic agent that targets the COX-2 and PI3K/Akt signaling pathways in melanomas to inhibit tumor development.	2-amino-4-(1-(carboxymethylcarbamoyl)-2-(5-phenyl-1-(4-sulfamoylphenyl)-1H-pyrazol-3-yl)methylselanylthiol-ethylcarbamoyl)butryic acid	44-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-111
23220503-5	2013	Cannabidiol-induced apoptosis was paralleled by upregulation of COX-2 and PPAR-gamma mRNA and protein expression with a maximum induction of COX-2 mRNA after 8 hours and continuous increases of PPAR-gamma mRNA when compared with vehicle.	Cannabidiol	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-69
23220503-5	2013	Cannabidiol-induced apoptosis was paralleled by upregulation of COX-2 and PPAR-gamma mRNA and protein expression with a maximum induction of COX-2 mRNA after 8 hours and continuous increases of PPAR-gamma mRNA when compared with vehicle.	Cannabidiol	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	141-146
23220503-6	2013	In response to cannabidiol, tumor cell lines exhibited increased levels of COX-2-dependent prostaglandins (PG) among which PGD(2) and 15-deoxy-Delta(12,14)-PGJ(2) (15d-PGJ(2)) caused a translocation of PPAR-gamma to the nucleus and induced a PPAR-gamma-dependent apoptotic cell death.	Cannabidiol	15-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
23220503-6	2013	In response to cannabidiol, tumor cell lines exhibited increased levels of COX-2-dependent prostaglandins (PG) among which PGD(2) and 15-deoxy-Delta(12,14)-PGJ(2) (15d-PGJ(2)) caused a translocation of PPAR-gamma to the nucleus and induced a PPAR-gamma-dependent apoptotic cell death.	Prostaglandins	91-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
23220503-6	2013	In response to cannabidiol, tumor cell lines exhibited increased levels of COX-2-dependent prostaglandins (PG) among which PGD(2) and 15-deoxy-Delta(12,14)-PGJ(2) (15d-PGJ(2)) caused a translocation of PPAR-gamma to the nucleus and induced a PPAR-gamma-dependent apoptotic cell death.	Prostaglandins	107-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
23220503-8	2013	Together, our data show a novel proapoptotic mechanism of cannabidiol involving initial upregulation of COX-2 and PPAR-gamma and a subsequent nuclear translocation of PPAR-gamma by COX-2-dependent PGs.	Cannabidiol	58-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
23220503-8	2013	Together, our data show a novel proapoptotic mechanism of cannabidiol involving initial upregulation of COX-2 and PPAR-gamma and a subsequent nuclear translocation of PPAR-gamma by COX-2-dependent PGs.	Cannabidiol	58-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	181-186
23220503-8	2013	Together, our data show a novel proapoptotic mechanism of cannabidiol involving initial upregulation of COX-2 and PPAR-gamma and a subsequent nuclear translocation of PPAR-gamma by COX-2-dependent PGs.	Phosphatidylglycerols	197-200	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	181-186
23840918-7	2013	Luteolin and kaempferol significantly reduced LPS-induced secretion of proinflammatory cytokines (IL-6 and IL-8) and prostaglandins (PGE(2) and PGF(2alpha)) in fetal membranes, IL-1beta-induced COX-2 gene expression and prostaglandin production in myometrium, and IL-1beta-induced MMP-9 activity in amnion and myometrial cells.	kaempferol	13-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	194-199
22665048-5	2013	Among these factors, generation of PGE2 in a COX-2-dependent fashion appears to play a dominant role in the stimulatory arm of tubular control of renin release.	Dinoprostone	35-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-50
22665048-6	2013	[NaCl] is a determinant of local PG release over an appropriate concentration range, and blockade of COX-2 activity interferes with the NaCl dependency of renin secretion.	Sodium Chloride	136-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-106
23441213-1	2013	This study aimed at evaluating the relative contribution of endothelial cyclooxygenase-1 and -2 (COX-1 and COX-2) to prostacyclin (PGI(2)) production in the presence of mild oxidative stress resulting from autooxidation of polyphenols such as (-)-epigallocatechin 3-gallate (EGCG), using both endothelial cells in culture and isolated blood vessels.	Epoprostenol	117-129	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-112
23441213-6	2013	Concomitant treatment with a selective COX-1 inhibitor completely prevented the vasorelaxation as well as the increase in PGI(2) accumulation in the perfusate observed in EGCG-treated aortic rings, while a selective COX-2 inhibitor was completely uneffective.	epigallocatechin gallate	171-175	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	216-221
23457497-7	2013	Using inhibitors of cyclooxygenase and prostaglandin receptor antagonists, we found that beta2 adrenoceptor desensitization was mediated through ASMC derived COX-2 induced prostaglandins.	asmc	145-149	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	158-163
23457497-7	2013	Using inhibitors of cyclooxygenase and prostaglandin receptor antagonists, we found that beta2 adrenoceptor desensitization was mediated through ASMC derived COX-2 induced prostaglandins.	Prostaglandins	172-186	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	158-163
23457497-11	2013	It was deduced that the mechanism by which beta2 adrenoceptor desensitization occurs was by pattern recognition receptor activation of COX-2 induced prostaglandins.	Prostaglandins	149-163	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-140
23358696-1	2013	BACKGROUND AND PURPOSE: Celecoxib (CXB) is a widely prescribed COX-2 inhibitor used clinically to treat pain and inflammation.	Celecoxib	24-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-68
23358696-1	2013	BACKGROUND AND PURPOSE: Celecoxib (CXB) is a widely prescribed COX-2 inhibitor used clinically to treat pain and inflammation.	Celecoxib	35-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-68
23358696-2	2013	Recently, COX-2 independent mechanisms have been described to be the targets of CXB.	Celecoxib	80-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
23358696-6	2013	Our study was aimed at establishing the role of COX-2 independent M current activation in the analgesic action of CXB.	Celecoxib	114-117	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-53
23358696-8	2013	UMC is a more potent inhibitor of COX-2 than CXB while DMC has no COX-2 inhibiting activity.	umc	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-39
23358696-9	2013	We found that CXB, UMC and DMC concentration-dependently activated Kv7.2/7.3 channels expressed in HEK293 cells and the M-type current in dorsal root ganglia neurons, negatively shifted I-V curve of Kv7.2/7.3 channels, with a potency and efficiency inverse to their COX-2 inhibitory potential.	Celecoxib	14-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	266-271
23358696-9	2013	We found that CXB, UMC and DMC concentration-dependently activated Kv7.2/7.3 channels expressed in HEK293 cells and the M-type current in dorsal root ganglia neurons, negatively shifted I-V curve of Kv7.2/7.3 channels, with a potency and efficiency inverse to their COX-2 inhibitory potential.	umc	19-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	266-271
23358696-9	2013	We found that CXB, UMC and DMC concentration-dependently activated Kv7.2/7.3 channels expressed in HEK293 cells and the M-type current in dorsal root ganglia neurons, negatively shifted I-V curve of Kv7.2/7.3 channels, with a potency and efficiency inverse to their COX-2 inhibitory potential.	2,5-dimethylcelecoxib	27-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	266-271
23300980-5	2013	Such blunted prostanoid production was paralleled by a reduction in COX-2 gene expression, whereas other pro-inflammatory mediators, namely interleukin-1beta (IL-1 beta) and -6 (IL-6) showed a trend to increased gene expression.	Prostaglandins	13-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-73
23326583-0	2013	ATP mediates NADPH oxidase/ROS generation and COX-2/PGE2 expression in A549 cells: role of P2 receptor-dependent STAT3 activation.	Adenosine Triphosphate	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
23326583-1	2013	BACKGROUND: Up-regulation of cyclooxygenase (COX)-2 and its metabolite prostaglandin E(2) (PGE(2)) are frequently implicated in lung inflammation.	Dinoprostone	71-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-51
23326583-1	2013	BACKGROUND: Up-regulation of cyclooxygenase (COX)-2 and its metabolite prostaglandin E(2) (PGE(2)) are frequently implicated in lung inflammation.	Dinoprostone	91-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-51
23326583-2	2013	Extracellular nucleotides, such as ATP have been shown to act via activation of P2 purinoceptors, leading to COX-2 expression in various inflammatory diseases, such as lung inflammation.	Adenosine Triphosphate	35-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-114
23326583-3	2013	However, the mechanisms underlying ATP-induced COX-2 expression and PGE(2) release remain unclear.	Adenosine Triphosphate	35-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
23326583-9	2013	SIGNIFICANCE: Taken together, these results showed that ATPgammaS induced COX-2 expression and PGE(2) production via a P2 receptor/PKC/NADPH oxidase/ROS/Jak2/STAT3/cPLA(2) signaling pathway in A549 cells.	ros	149-152	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
23380599-2	2013	As endocannabinoids also form novel prostaglandin ethanolamides (prostamides) via COX-2, we investigated the effects of prostamides and other COX-2 mediators on tissue damage in an ex vivo human mucosal explant colitis model.	Bimatoprost	65-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
22893200-5	2013	The extent of inhibition of COX-2-dependent prostacyclin, an important vasoprotective and anti-thrombotic pathway, in the absence of a complete suppression of COX-1-dependent platelet function, at common doses of NSAIDs, might play a role in CV toxicity.	Epoprostenol	44-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
24050308-10	2013	Three possible sources of reactive oxygen species were identified, the hypohalous acid generating peroxidase enzymes lactoperoxidase (LPO) and myeloperoxidase (MPO), nicotinamide adenine dinucleotide phosphate (NADPH)-dependent oxidase 5 (NOX5), and PTGS2 (COX-2) mediated arachidonic acid metabolism.	Reactive Oxygen Species	26-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	257-262
24050308-11	2013	Each monoHAA exposure caused an increase in COX-2 mRNA levels.	monohaa	5-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-49
24211633-2	2013	The compound 3f exhibited potent selective COX-2 inhibition of 59.48% in comparison to standard drug celecoxib (66.36% inhibition).	Celecoxib	101-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
23147035-6	2013	These COX-2(+) macrophages were the primary source of PGE(2) release in the lungs, since there was only slight enhancement of NE-associated COX-1 and there was no change in COX-1/COX-2 levels in alveolar epithelial cells following treatment with CT and/or BCG.	Dinoprostone	54-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	6-11
23147035-8	2013	When CT followed BCG treatment, macrophages in vitro had elevated COX-2-mediated PGE(2) release, but macrophages in vivo exhibited less activation of NE-associated COX-2.	Dinoprostone	81-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-71
23147035-9	2013	Our results indicate that inclusion of CT in the intranasal BCG vaccination enhances COX-2-mediated PGE(2) release by alveolar macrophages and further suggest that the effect of CT in vivo is mediated by other lung cells.	Dinoprostone	100-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-90
23533709-0	2013	Design, Synthesis, and Evaluation of New Tripeptides as COX-2 Inhibitors.	tripeptides	41-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-61
22990668-8	2013	RESULTS: Treatment of RA FLS with GW3965 induced dose-dependent reductions in mRNA expression of pro-inflammatory mediators (IL-1beta, IL-6, MMP-9, CCL-2, CCL-7, and COX-2).	GW 3965	34-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	166-171
23758148-9	2013	The bamboo salts, especially 9x bamboo salt, also significantly (p&lt;0.05) downregulated the expression of inflammation-related NF-kappaB, iNOS, and COX-2, and upregulated the gene expression of IkappaB-alpha compared to the other salt sample.	bamboo salt	4-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	150-155
23758148-9	2013	The bamboo salts, especially 9x bamboo salt, also significantly (p&lt;0.05) downregulated the expression of inflammation-related NF-kappaB, iNOS, and COX-2, and upregulated the gene expression of IkappaB-alpha compared to the other salt sample.	9x bamboo salt	29-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	150-155
23758148-9	2013	The bamboo salts, especially 9x bamboo salt, also significantly (p&lt;0.05) downregulated the expression of inflammation-related NF-kappaB, iNOS, and COX-2, and upregulated the gene expression of IkappaB-alpha compared to the other salt sample.	Salts	11-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	150-155
24191167-6	2013	We found that COX-2/PGE2 signaling pathway, which plays key roles in the development of cancer, is involved in the antitumor activities of these saponins.	Saponins	145-153	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
24191167-7	2013	These data provide the evidence that triterpenoid saponins can induce apoptosis via COX-2/PGE2 pathway, implying a preventive role of saponins from Anemone flaccida in tumor.	triterpenoid TP-222	37-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-89
24191167-7	2013	These data provide the evidence that triterpenoid saponins can induce apoptosis via COX-2/PGE2 pathway, implying a preventive role of saponins from Anemone flaccida in tumor.	Saponins	50-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-89
24191167-7	2013	These data provide the evidence that triterpenoid saponins can induce apoptosis via COX-2/PGE2 pathway, implying a preventive role of saponins from Anemone flaccida in tumor.	Dinoprostone	90-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-89
23874018-5	2013	In addition to high levels of expression of the "constitutive" rate-limiting enzyme responsible for prostanoid production, COX-1, the "inducible" isoform of cyclooxygenase, COX-2, is also constitutively expressed in the kidney and is highly regulated in response to alterations in intravascular volume.	Prostaglandins	100-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	173-178
23874018-7	2013	We and others have shown that COX-2-derived prostaglandins exert important physiologic functions in maintenance of renal blood flow, mediation of renin release, and regulation of sodium excretion.	Prostaglandins	44-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-35
23369255-0	2012	Removal of Co(II), Cu(II) and Pb(II) ions by polymer based 2-hydroxyethyl methacrylate: thermodynamics and desorption studies.	Polymers	45-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-17
23596884-8	2013	Western blot was used for detecting the effect of TFGR and isoliquiritigenins on iNOS, COX-2 and MAPK signal transduction pathways.	isoliquiritigenin	59-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-92
23596884-13	2013	Isoliquiritigenin, a flavonoid monomer, could inhibited iNOS, COX-2 gene and protein expression and gene expressions of IL-1beta and IL-6, and upside-regulated gene expression of PPAR-gamma.	isoliquiritigenin	0-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
23042587-10	2012	Magnetic studies on 1 and 2 demonstrated that the bis(syn-skew-carboxylate) bridges between octahedral Co(II) ions induce ferromagnetic coupling; 4 is peculiar in that octahedral and tetrahedral Co(II) ions are linked by mixed syn-syn and syn-skew carboxylate bridges, which give rise to antiferromagnetic coupling.	carboxylate	63-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-109
23064659-0	2012	Rational design of two bpy-bridged 3D and 2D Co(II) open frameworks with similar amino-acid-based Schiff bases.	Schiff Bases	98-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-51
23064659-4	2012	Complex 1 features an unprecedented threefold interpenetrated diamond network based on the fan-shaped Co(II)(4)(mu(2)-napala)(4) molecular square node and bpy linker, which represents the first example of 3D framework among the amino-acid-based Schiff base complexes with salicylaldehyde or its derivatives.	(2)-napala	114-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-108
23369255-0	2012	Removal of Co(II), Cu(II) and Pb(II) ions by polymer based 2-hydroxyethyl methacrylate: thermodynamics and desorption studies.	hydroxyethyl methacrylate	59-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-17
23064659-5	2012	In 2, adjacent Co(II) ions are bridged by mu(2)-napgly(2-) to form left- and right-handed [Co(II)(mu(2)-napgly)](n) helical chains.	mu(2)-napgly)	98-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-21
23064659-5	2012	In 2, adjacent Co(II) ions are bridged by mu(2)-napgly(2-) to form left- and right-handed [Co(II)(mu(2)-napgly)](n) helical chains.	mu(2)-napgly)	98-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-97
23369255-3	2012	Using the Langmuir model equation, the monolayer removal capacity of PHEMA surface was found to be 0.7388, 0.8396 and 3.0367 mg/g for Co(II), Cu(IotaIota) and Pb(II) ions and removal capacity of P(MMA-HEMA) was found to be 28.8442, 31.1526 and 31.4465 mg/g for Co(II), Cu(IotaIota) and Pb(II) ions, respectively.	Phosphorus	69-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-140
23369255-3	2012	Using the Langmuir model equation, the monolayer removal capacity of PHEMA surface was found to be 0.7388, 0.8396 and 3.0367 mg/g for Co(II), Cu(IotaIota) and Pb(II) ions and removal capacity of P(MMA-HEMA) was found to be 28.8442, 31.1526 and 31.4465 mg/g for Co(II), Cu(IotaIota) and Pb(II) ions, respectively.	Phosphorus	69-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	261-267
23369255-4	2012	Changes in the standard Gibbs free energy (DeltaG0), standard enthalpy (DeltaH0) and standard entropy (DeltaS0) showed that the removals of mentioned ions onto PHEMA and P(MMA-HEMA) are spontaneous and exothermic at 293-323 K. The maximum desorption efficiency was 75.26% for Pb(II) using 0.100 M HNO3, 70.10% for Cu(II) using 0.100 M HCl, 59.20% for 0.100 M HCl 63.67% Co(II).	mma	172-175	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	370-376
23369255-4	2012	Changes in the standard Gibbs free energy (DeltaG0), standard enthalpy (DeltaH0) and standard entropy (DeltaS0) showed that the removals of mentioned ions onto PHEMA and P(MMA-HEMA) are spontaneous and exothermic at 293-323 K. The maximum desorption efficiency was 75.26% for Pb(II) using 0.100 M HNO3, 70.10% for Cu(II) using 0.100 M HCl, 59.20% for 0.100 M HCl 63.67% Co(II).	hydroxyethyl methacrylate	161-165	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	370-376
23007663-1	2012	Reaction of imidazole aldehydes with dihydrazino derivatives of 2-phenylpyrimidine provides a family of bis(acylhydrazone) ligands which form [2 x 2] metallogrid complexes with transition metal ions including Fe(II), Co(II), Cu(II) and Zn(II).	dihydrazino	37-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	217-223
23249419-3	2012	This study investigated the antitumor effects of the selective COX-2 inhibitor, Celecoxib, on breast cancer in vitro and in vivo.	Celecoxib	80-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-68
23249419-11	2012	Celecoxib effectively down-regulated the expression of COX-2.	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-60
23007663-1	2012	Reaction of imidazole aldehydes with dihydrazino derivatives of 2-phenylpyrimidine provides a family of bis(acylhydrazone) ligands which form [2 x 2] metallogrid complexes with transition metal ions including Fe(II), Co(II), Cu(II) and Zn(II).	imidazole aldehydes	12-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	217-223
23007663-1	2012	Reaction of imidazole aldehydes with dihydrazino derivatives of 2-phenylpyrimidine provides a family of bis(acylhydrazone) ligands which form [2 x 2] metallogrid complexes with transition metal ions including Fe(II), Co(II), Cu(II) and Zn(II).	2-Phenylpyrimidine	64-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	217-223
23007663-1	2012	Reaction of imidazole aldehydes with dihydrazino derivatives of 2-phenylpyrimidine provides a family of bis(acylhydrazone) ligands which form [2 x 2] metallogrid complexes with transition metal ions including Fe(II), Co(II), Cu(II) and Zn(II).	bis(acylhydrazone)	104-122	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	217-223
23007663-1	2012	Reaction of imidazole aldehydes with dihydrazino derivatives of 2-phenylpyrimidine provides a family of bis(acylhydrazone) ligands which form [2 x 2] metallogrid complexes with transition metal ions including Fe(II), Co(II), Cu(II) and Zn(II).	Metals	150-155	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	217-223
23007663-1	2012	Reaction of imidazole aldehydes with dihydrazino derivatives of 2-phenylpyrimidine provides a family of bis(acylhydrazone) ligands which form [2 x 2] metallogrid complexes with transition metal ions including Fe(II), Co(II), Cu(II) and Zn(II).	ammonium ferrous sulfate	209-215	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	217-223
23007663-1	2012	Reaction of imidazole aldehydes with dihydrazino derivatives of 2-phenylpyrimidine provides a family of bis(acylhydrazone) ligands which form [2 x 2] metallogrid complexes with transition metal ions including Fe(II), Co(II), Cu(II) and Zn(II).	cu(ii)	225-231	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	217-223
23007663-1	2012	Reaction of imidazole aldehydes with dihydrazino derivatives of 2-phenylpyrimidine provides a family of bis(acylhydrazone) ligands which form [2 x 2] metallogrid complexes with transition metal ions including Fe(II), Co(II), Cu(II) and Zn(II).	Zinc	236-242	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	217-223
24281340-3	2012	At low-doses given every 24 h, aspirin is acting by a complete and persistent inhibition of cyclooxygenase (COX)-1 in platelets (in the pre-systemic circulation) while causing a limited and rapidly reversible inhibitory effect on COX-2 and/or COX-1 expressed in nucleated cells.	Aspirin	31-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	230-235
23263802-5	2012	In the MTT assay in vitro, both compounds were identified as potent and selective COX-2 inhibitors.	monooxyethylene trimethylolpropane tristearate	7-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
23220503-0	2013	COX-2 and PPAR-gamma confer cannabidiol-induced apoptosis of human lung cancer cells.	Cannabidiol	28-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
23220503-4	2013	Apoptotic cell death by cannabidiol was suppressed by NS-398 (COX-2 inhibitor), GW9662 (PPAR-gamma antagonist), and siRNA targeting COX-2 and PPAR-gamma.	Cannabidiol	24-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
23220503-4	2013	Apoptotic cell death by cannabidiol was suppressed by NS-398 (COX-2 inhibitor), GW9662 (PPAR-gamma antagonist), and siRNA targeting COX-2 and PPAR-gamma.	Cannabidiol	24-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-137
23042094-8	2012	Treatment of the cells with curcumin and siRNA-based knockdown of CXCL1 and -2 induce apoptosis, inhibit proliferation and downregulate several important metastasis-promoting factors like COX2, SPARC and EFEMP.	Curcumin	28-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	188-192
22707304-5	2012	NF-kappaB-mediated signaling during HL-60 macrophage differentiation was reversed by EGCG, in part through reduced IkappaB phosphorylation and led to the inhibition of moderately to highly expressed NF-kappaB gene targets among which the matrix metalloproteinase (MMP)-9 and the cyclooxygenase (COX)-2.	epigallocatechin gallate	85-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	279-301
22707304-6	2012	In contrast, EGCG exhibited low efficacy in reversing NF-kappaB-regulated genes and showed selective antagonism toward COX-2 expression while that of MMP-9 remained high in terminally differentiated macrophages.	epigallocatechin gallate	13-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-124
23027625-5	2012	Treatment with tectorigenin inhibited the nuclear translocation of NFkappaB and the expression of NFkappaB-dependent genes such as FLIP, XIAP, Bcl-2, Bcl-xL and COX-2, which are known to be associated with chemoresistance.	tectorigenin	15-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	161-166
24052731-6	2012	We identified two patients with candidate mutations: m.6852G&gt;A that produces an amino acid change of glycine to serine in the MT-CO1 gene and m.8033A&gt;G (Ile Val) in the MT-CO2 gene.	Glycine	104-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	175-181
24052731-6	2012	We identified two patients with candidate mutations: m.6852G&gt;A that produces an amino acid change of glycine to serine in the MT-CO1 gene and m.8033A&gt;G (Ile Val) in the MT-CO2 gene.	Serine	115-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	175-181
22722879-12	2012	Ionomycin increased c-myc and cox-2 expression in HepG2 cells, but not in siNFATc1 HepG2 cells.	Ionomycin	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-35
22676065-5	2012	Moreover, we also found that dexamethasone combined with PEMF upregulated the mRNA expression of IGF-1 at the early stage after the stimulation of PEMF and improved the decrease of COX-2 mRNA expression induced by dexamethasone at the late stage after the stimulation of PEMF.	Dexamethasone	29-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	181-186
22676065-5	2012	Moreover, we also found that dexamethasone combined with PEMF upregulated the mRNA expression of IGF-1 at the early stage after the stimulation of PEMF and improved the decrease of COX-2 mRNA expression induced by dexamethasone at the late stage after the stimulation of PEMF.	Dexamethasone	214-227	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	181-186
22676065-5	2012	Moreover, we also found that dexamethasone combined with PEMF upregulated the mRNA expression of IGF-1 at the early stage after the stimulation of PEMF and improved the decrease of COX-2 mRNA expression induced by dexamethasone at the late stage after the stimulation of PEMF.	pemf	57-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	181-186
22006370-8	2012	These findings indicate that the COX-2/PGE(2) /EP3 signaling pathway is involved in IGF-1-stimulated mammary tumorigenesis and that COX-2-selective inhibitors may be useful in the prevention or treatment of breast cancer associated with elevated IGF-1 levels in humans.	Prostaglandins E	39-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-38
23086696-1	2012	BACKGROUND AND OBJECTIVE: Ibuprofen is a non-selective cyclo-oxygenase (COX)-1/COX-2 inhibitor used to treat pain conditions and inflammation.	Ibuprofen	26-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-84
22640168-1	2012	Fibrosis, increased amounts of immune cells and expression of COX-2 in the testes of infertility patients provide circumstantial evidence for a specific testicular milieu, in which reactive oxygen species (ROS) could be increased.	Reactive Oxygen Species	181-204	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
22640168-1	2012	Fibrosis, increased amounts of immune cells and expression of COX-2 in the testes of infertility patients provide circumstantial evidence for a specific testicular milieu, in which reactive oxygen species (ROS) could be increased.	Reactive Oxygen Species	206-209	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
22640168-3	2012	Primary peritubular cells of the human testis, from men with normal spermatogenesis (HTPCs) and infertile patients (HTPC-Fs), previously allowed us to identify an end product of COX-2 action, a prostaglandin derivative (15dPGJ2), which acts via ROS to alter the phenotype of peritubular cells, at least in vitro.	Prostaglandins	194-207	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	178-183
22640168-3	2012	Primary peritubular cells of the human testis, from men with normal spermatogenesis (HTPCs) and infertile patients (HTPC-Fs), previously allowed us to identify an end product of COX-2 action, a prostaglandin derivative (15dPGJ2), which acts via ROS to alter the phenotype of peritubular cells, at least in vitro.	Reactive Oxygen Species	245-248	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	178-183
22992945-10	2012	W146, a known S1P1 receptor antagonist, inhibited the active form of NF-kappaB p65 and COX-2 expression induced by IL-1beta.	W146	0-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-92
23026344-1	2012	The results show rhombic distortion around the Ni(II) ion, with the ion being entered the lattice substitutionally in place of Co(II).	Nickel(2+)	47-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	127-133
22971613-0	2012	1,25-Dihydroxyvitamin D3 inhibits growth of the breast cancer cell line             MCF-7 and downregulates cytochrome P4501B1 through the COX-2/PGE2 pathway.	Calcitriol	0-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-144
22971613-0	2012	1,25-Dihydroxyvitamin D3 inhibits growth of the breast cancer cell line             MCF-7 and downregulates cytochrome P4501B1 through the COX-2/PGE2 pathway.	Dinoprostone	145-149	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-144
22971613-1	2012	Cytochrome P4501B1 (CYP1B1) is responsible for tumor progression in estrogen             receptor-positive breast cancer due to its key role in estrogen metabolism, which             is upregulated by PGE2, the main product of COX-2 that is found to be overexpressed             in many breast tumors.	Dinoprostone	201-205	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	227-232
22971613-2	2012	Previous studies reported that inhibition of the COX-2/PGE2             pathway, by 1,25-dihydroxyvitamin D3 in MCF-7 breast cancer cells.	Dinoprostone	55-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-54
22971613-2	2012	Previous studies reported that inhibition of the COX-2/PGE2             pathway, by 1,25-dihydroxyvitamin D3 in MCF-7 breast cancer cells.	Calcitriol	84-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-54
22971613-4	2012	We also             investigated whether 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] downregulates CYP1B1             via the COX-2/PGE2 pathway in MCF-7 cells.	Calcitriol	67-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-126
22971613-10	2012	Taken together, these             results suggest that the COX-2/PGE2 pathway positively regulates the expression             of CYP1B1 in breast cancer.	Dinoprostone	65-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-64
22971613-11	2012	1,25-Dihydroxyvitamin D3 inhibits the growth of MCF-7             cells and downregulates CYP1B1 mediated by the COX-2/PGE2 pathway.	Calcitriol	0-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-118
22971613-11	2012	1,25-Dihydroxyvitamin D3 inhibits the growth of MCF-7             cells and downregulates CYP1B1 mediated by the COX-2/PGE2 pathway.	Dinoprostone	119-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-118
23044918-2	2012	Furthermore, under identical reaction conditions, using a Co(II) salt instead, a novel 3D framework material, trip-MOF-1, was isolated and its sensitivity towards picric acid was also evaluated.	picric acid	163-174	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-64
23092306-7	2012	XPS determined binding energies were interpreted to imply that after oxidation in an oxygen/argon mixture of the grafted sample both Pd(II) and Co(II) were oxidized to produce PdO(2) (337.5 eV) and Co(III)(2)O(3) (781.1 eV) which most probably interacts with the silicon surface via Pd(IV)-O-Si and Co(III)-O-Si bonds.	Oxygen	85-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	144-150
23092306-7	2012	XPS determined binding energies were interpreted to imply that after oxidation in an oxygen/argon mixture of the grafted sample both Pd(II) and Co(II) were oxidized to produce PdO(2) (337.5 eV) and Co(III)(2)O(3) (781.1 eV) which most probably interacts with the silicon surface via Pd(IV)-O-Si and Co(III)-O-Si bonds.	Argon	92-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	144-150
23092306-7	2012	XPS determined binding energies were interpreted to imply that after oxidation in an oxygen/argon mixture of the grafted sample both Pd(II) and Co(II) were oxidized to produce PdO(2) (337.5 eV) and Co(III)(2)O(3) (781.1 eV) which most probably interacts with the silicon surface via Pd(IV)-O-Si and Co(III)-O-Si bonds.	pdo(2)	176-182	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	144-150
23092306-7	2012	XPS determined binding energies were interpreted to imply that after oxidation in an oxygen/argon mixture of the grafted sample both Pd(II) and Co(II) were oxidized to produce PdO(2) (337.5 eV) and Co(III)(2)O(3) (781.1 eV) which most probably interacts with the silicon surface via Pd(IV)-O-Si and Co(III)-O-Si bonds.	co(iii)(2)o(3)	198-212	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	144-150
23092306-7	2012	XPS determined binding energies were interpreted to imply that after oxidation in an oxygen/argon mixture of the grafted sample both Pd(II) and Co(II) were oxidized to produce PdO(2) (337.5 eV) and Co(III)(2)O(3) (781.1 eV) which most probably interacts with the silicon surface via Pd(IV)-O-Si and Co(III)-O-Si bonds.	Silicon	263-270	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	144-150
23092306-7	2012	XPS determined binding energies were interpreted to imply that after oxidation in an oxygen/argon mixture of the grafted sample both Pd(II) and Co(II) were oxidized to produce PdO(2) (337.5 eV) and Co(III)(2)O(3) (781.1 eV) which most probably interacts with the silicon surface via Pd(IV)-O-Si and Co(III)-O-Si bonds.	Silicon	292-294	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	144-150
23092306-7	2012	XPS determined binding energies were interpreted to imply that after oxidation in an oxygen/argon mixture of the grafted sample both Pd(II) and Co(II) were oxidized to produce PdO(2) (337.5 eV) and Co(III)(2)O(3) (781.1 eV) which most probably interacts with the silicon surface via Pd(IV)-O-Si and Co(III)-O-Si bonds.	co(iii)	198-205	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	144-150
23092306-7	2012	XPS determined binding energies were interpreted to imply that after oxidation in an oxygen/argon mixture of the grafted sample both Pd(II) and Co(II) were oxidized to produce PdO(2) (337.5 eV) and Co(III)(2)O(3) (781.1 eV) which most probably interacts with the silicon surface via Pd(IV)-O-Si and Co(III)-O-Si bonds.	Silicon	309-311	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	144-150
22884582-7	2012	Further analysis indicated that the major COX-2 product, prostaglandin E(2), directly enhanced proliferation and invasiveness of the epithelial cancer cells in the absence of fibroblasts.	Dinoprostone	57-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47
23134429-0	2012	Wheel-shaped icosanuclear homo- and heterometallic complexes of Ni(II), Co(II), and Cu(II) ions supported by unsymmetrical aminoalcohol ligands.	Amino Alcohols	123-135	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
23001132-8	2012	Time resolved spectroscopic measurements were performed on compound 6, which proved an intramolecular electron transfer from an excited Ru(II) metal centre to the Co(II) metal centre via the bridging L-pyr ligand.	pyr	202-205	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	163-169
22595400-0	2012	Mediterranean diet polyphenols reduce inflammatory angiogenesis through MMP-9 and COX-2 inhibition in human vascular endothelial cells: a potentially protective mechanism in atherosclerotic vascular disease and cancer.	Polyphenols	19-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
22595400-8	2012	Our findings reveal that olive oil and red wine polyphenols reduce inflammatory angiogenesis in cultured endothelial cells, through MMP-9 and COX-2 inhibition, supporting a potential protective role for dietary polyphenols in atherosclerotic vascular disease and cancer.	Polyphenols	48-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	142-147
23095055-1	2012	NMR paramagnetic relaxation enhancements (PREs) of a series of structurally characterized, trigonal bis-trispyrazolylborate (Tp) chelates of high-spin Co(II), spanning 100-850 MHz in field, are reported.	bis-trispyrazolylborate	100-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-157
23095055-1	2012	NMR paramagnetic relaxation enhancements (PREs) of a series of structurally characterized, trigonal bis-trispyrazolylborate (Tp) chelates of high-spin Co(II), spanning 100-850 MHz in field, are reported.	tp	125-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-157
23001132-8	2012	Time resolved spectroscopic measurements were performed on compound 6, which proved an intramolecular electron transfer from an excited Ru(II) metal centre to the Co(II) metal centre via the bridging L-pyr ligand.	ru(ii) metal	136-148	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	163-169
23001132-8	2012	Time resolved spectroscopic measurements were performed on compound 6, which proved an intramolecular electron transfer from an excited Ru(II) metal centre to the Co(II) metal centre via the bridging L-pyr ligand.	Metals	143-148	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	163-169
23001132-8	2012	Time resolved spectroscopic measurements were performed on compound 6, which proved an intramolecular electron transfer from an excited Ru(II) metal centre to the Co(II) metal centre via the bridging L-pyr ligand.	l	200-201	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	163-169
22968840-3	2012	The Co(II) ion has octahedral coordination [CoO(3)F(3)] and builds up a 3D framework by corner- and edge sharing.	coo(3)f(3)	44-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
22884582-8	2012	Moreover, a selective COX-2 inhibitor, NS-398, blocked the proliferative and invasive effect of both normal and cancer associate fibroblasts on the epithelial cancer cells, with or without stimulation of IL-1beta.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	39-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-27
23036202-5	2012	We found that GTE induced ANX1 and inhibited COX-2 expression in lung cancer A549, H157 and H460 cell lines.	gte	14-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-50
23036202-7	2012	Silence of ANX1 in cells abrogates the inhibitory activity on COX-2, indicating that the anti-inflammatory activity of GTE is mediated at least partially by the up-regulation of ANX1.	gte	119-122	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
23047224-0	2012	Molecular modeling, synthesis and screening of some new 4-thiazolidinone derivatives with promising selective COX-2 inhibitory activity.	4-thiazolidinone	56-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-115
23284372-5	2012	The Co(II) ion lies on an inversion centre and adopts an almost regular octa-hedral N(4)O(2) coordination geometry.	octa-hedral n	72-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
23284372-6	2012	Adjacent Co(II) atoms are connected by two bridging dicyanamide ligands, resulting in the formation of neutral chains parallel to the b axis.	trimethylsulfonium dicyanamide	52-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	9-15
22910222-0	2012	The use of anti-COX2 siRNA coated onto PLGA nanoparticles loading dexamethasone in the treatment of rheumatoid arthritis.	Dexamethasone	66-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-20
23036953-6	2012	COX-2 docking score of the active compound 5i was found to be better than standard celecoxib.	Celecoxib	83-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
23047231-0	2012	Sulfonilamidothiopyrimidone and thiopyrimidone derivatives as selective COX-2 inhibitors: synthesis, biological evaluation, and docking studies.	sulfonilamidothiopyrimidone	0-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
23047231-0	2012	Sulfonilamidothiopyrimidone and thiopyrimidone derivatives as selective COX-2 inhibitors: synthesis, biological evaluation, and docking studies.	thiopyrimidone	13-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
23047231-6	2012	Western blot of COX-2 confirmed the inhibition on the PGE(2) secretion.	Dinoprostone	54-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-21
23132776-0	2012	Differential effect of DDT, DDE, and DDD on COX-2 expression in the human trophoblast derived HTR-8/SVneo cells.	DDT	23-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-49
23132776-1	2012	The purpose of this study was to investigate the effect of 1,1,1-trichloro-2,2-bis-(chlorophenyl)ethane (DDT), 1,1-bis-(chlorophenyl)-2,2-dichloroethene (DDE), and 1,1-dichloro-2,2-bis(chlorophenyl)ethane (DDD) isomers on COX-2 expression in a human trophoblast-derived cell line.	DDT	105-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	222-227
23132776-6	2012	It is concluded that DDE and DDD exposure induce the expression of COX-2 protein, leading to increased prostaglandin E2 production.	Dichlorodiphenyl Dichloroethylene	21-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-72
23132776-6	2012	It is concluded that DDE and DDD exposure induce the expression of COX-2 protein, leading to increased prostaglandin E2 production.	Dichlorodiphenyldichloroethane	29-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-72
23132776-6	2012	It is concluded that DDE and DDD exposure induce the expression of COX-2 protein, leading to increased prostaglandin E2 production.	Dinoprostone	103-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-72
23132776-7	2012	Interestingly, the regulation of COX-2 by these organochlorines pesticides appears to be at the translational level.	Hydrocarbons, Chlorinated	48-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-38
22983360-4	2012	COX-2-derived prostaglandin E(2) (PGE(2)) prevented HSPC exhaustion by limiting the production of reactive oxygen species (ROS) via inhibition of the kinase Akt and higher stromal-cell expression of the chemokine CXCL12, which is essential for stem-cell quiescence.	Dinoprostone	14-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
22983360-4	2012	COX-2-derived prostaglandin E(2) (PGE(2)) prevented HSPC exhaustion by limiting the production of reactive oxygen species (ROS) via inhibition of the kinase Akt and higher stromal-cell expression of the chemokine CXCL12, which is essential for stem-cell quiescence.	Dinoprostone	34-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
22983360-4	2012	COX-2-derived prostaglandin E(2) (PGE(2)) prevented HSPC exhaustion by limiting the production of reactive oxygen species (ROS) via inhibition of the kinase Akt and higher stromal-cell expression of the chemokine CXCL12, which is essential for stem-cell quiescence.	Reactive Oxygen Species	98-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
22983360-4	2012	COX-2-derived prostaglandin E(2) (PGE(2)) prevented HSPC exhaustion by limiting the production of reactive oxygen species (ROS) via inhibition of the kinase Akt and higher stromal-cell expression of the chemokine CXCL12, which is essential for stem-cell quiescence.	Reactive Oxygen Species	123-126	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
22820046-0	2012	Spectrophotometric and spectrofluorimetric studies on the selective sensing of fluoride ions by Co(II) and Ni(II) complexes of naphthoquinone derivative possessing enhanced H-bonding property.	Fluorides	79-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-113
22820046-0	2012	Spectrophotometric and spectrofluorimetric studies on the selective sensing of fluoride ions by Co(II) and Ni(II) complexes of naphthoquinone derivative possessing enhanced H-bonding property.	Naphthoquinones	127-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-113
22885116-0	2012	Co(II), Cd(II), Hg(II) and U(VI)O2 complexes of o-hydroxyacetophenone[N-(3-hydroxy-2-naphthoyl)] hydrazone: physicochemical study, thermal studies and antimicrobial activity.	2'-hydroxyacetophenone	48-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
22885116-0	2012	Co(II), Cd(II), Hg(II) and U(VI)O2 complexes of o-hydroxyacetophenone[N-(3-hydroxy-2-naphthoyl)] hydrazone: physicochemical study, thermal studies and antimicrobial activity.	n-(3-hydroxy-2-naphthoyl)] hydrazone	70-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
23043222-3	2012	In the present study, we identify the nonsteroidal anti-inflammatory drug carprofen as a multitarget-directed ligand that simultaneously inhibits cyclooxygenase-1 (COX-1), COX-2, and fatty acid amide hydrolase (FAAH).	carprofen	74-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	172-177
22998407-4	2012	The preparation of a four-coordinate Co(II) synthon was achieved with the tripodal ligand, N,N",N"-[2,2",2"-nitrilotris(ethane-2,1-diyl)]tris(2,4,6-trimethylbenzenesulfonamido, [MST](3-).	n,n",n"-[2,2",2"-nitrilotris(ethane-2,1-diyl)]tris(2,4,6-trimethylbenzenesulfonamido	91-175	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-43
22998407-5	2012	Water binds to [Co(II)MST](-) to form the five-coordinate [Co(II)MST(OH(2))](-) complex that was used to prepare the Co(II)/Ca(II) complex [Co(II)MST(mu-OH(2))Ca(II) 15-crown-5(OH(2))](+) ([Co(II)(mu-OH(2))Ca(II)OH(2)](+)).	Water	0-5	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
22998407-5	2012	Water binds to [Co(II)MST](-) to form the five-coordinate [Co(II)MST(OH(2))](-) complex that was used to prepare the Co(II)/Ca(II) complex [Co(II)MST(mu-OH(2))Ca(II) 15-crown-5(OH(2))](+) ([Co(II)(mu-OH(2))Ca(II)OH(2)](+)).	Water	0-5	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
22998407-5	2012	Water binds to [Co(II)MST](-) to form the five-coordinate [Co(II)MST(OH(2))](-) complex that was used to prepare the Co(II)/Ca(II) complex [Co(II)MST(mu-OH(2))Ca(II) 15-crown-5(OH(2))](+) ([Co(II)(mu-OH(2))Ca(II)OH(2)](+)).	Cobalt(2+)	16-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
22998407-5	2012	Water binds to [Co(II)MST](-) to form the five-coordinate [Co(II)MST(OH(2))](-) complex that was used to prepare the Co(II)/Ca(II) complex [Co(II)MST(mu-OH(2))Ca(II) 15-crown-5(OH(2))](+) ([Co(II)(mu-OH(2))Ca(II)OH(2)](+)).	Cobalt(2+)	16-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
22998407-5	2012	Water binds to [Co(II)MST](-) to form the five-coordinate [Co(II)MST(OH(2))](-) complex that was used to prepare the Co(II)/Ca(II) complex [Co(II)MST(mu-OH(2))Ca(II) 15-crown-5(OH(2))](+) ([Co(II)(mu-OH(2))Ca(II)OH(2)](+)).	Water	69-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
22998407-5	2012	Water binds to [Co(II)MST](-) to form the five-coordinate [Co(II)MST(OH(2))](-) complex that was used to prepare the Co(II)/Ca(II) complex [Co(II)MST(mu-OH(2))Ca(II) 15-crown-5(OH(2))](+) ([Co(II)(mu-OH(2))Ca(II)OH(2)](+)).	Water	69-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
22998407-5	2012	Water binds to [Co(II)MST](-) to form the five-coordinate [Co(II)MST(OH(2))](-) complex that was used to prepare the Co(II)/Ca(II) complex [Co(II)MST(mu-OH(2))Ca(II) 15-crown-5(OH(2))](+) ([Co(II)(mu-OH(2))Ca(II)OH(2)](+)).	mu-oh	150-155	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
23078372-4	2012	We carried out our experiments with an excess of 2,2"-bipyridyl as the chelating agent for free aqueous Co(II) ions, in order to avoid the formation of a cobalt oxide film on the electrode, as observed for other polyoxometalate catalysts.	2,2'-Dipyridyl	49-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-110
23078372-4	2012	We carried out our experiments with an excess of 2,2"-bipyridyl as the chelating agent for free aqueous Co(II) ions, in order to avoid the formation of a cobalt oxide film on the electrode, as observed for other polyoxometalate catalysts.	cobalt oxide	154-166	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-110
24009844-6	2012	The results showed that, in these cells, DPHC significantly and dose-dependently induced PGE2 synthesis by increasing the protein and mRNA levels of COX-1 and COX-2.	diphlorethohydroxycarmalol	41-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	159-164
24009844-6	2012	The results showed that, in these cells, DPHC significantly and dose-dependently induced PGE2 synthesis by increasing the protein and mRNA levels of COX-1 and COX-2.	Dinoprostone	89-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	159-164
24009844-7	2012	Interestingly, DPHC-induced COX-1 expression preceded that of COX-2.	diphlorethohydroxycarmalol	15-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
22735362-1	2012	AIM: To prospectively study the clinical renal effects of daily high-dose celecoxib, a COX-2 inhibitor, in a cohort of elderly sick men (mean age 74.5 years) with advanced prostate cancer.	Celecoxib	74-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-92
22890791-11	2012	In contrast, production of MMP9, CCL4, COX-2, and IL-23 is solely regulated by PGE(2) , but not by LXR activation, offering new perspectives for therapeutic interventions.	Prostaglandins E	79-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-44
22677879-3	2012	Retention of radionuclide (60)Co(II) from aqueous solution by sorption onto diatomite was investigated by using batch technique under various environmental conditions such as pH, ionic strength, humic acid (HA), fulvic acid (FA), and temperature.	Radioisotopes	13-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-36
22677879-3	2012	Retention of radionuclide (60)Co(II) from aqueous solution by sorption onto diatomite was investigated by using batch technique under various environmental conditions such as pH, ionic strength, humic acid (HA), fulvic acid (FA), and temperature.	diatomite	76-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-36
22677879-3	2012	Retention of radionuclide (60)Co(II) from aqueous solution by sorption onto diatomite was investigated by using batch technique under various environmental conditions such as pH, ionic strength, humic acid (HA), fulvic acid (FA), and temperature.	Humic Substances	195-205	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-36
22677879-3	2012	Retention of radionuclide (60)Co(II) from aqueous solution by sorption onto diatomite was investigated by using batch technique under various environmental conditions such as pH, ionic strength, humic acid (HA), fulvic acid (FA), and temperature.	Humic Substances	207-209	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-36
22677879-3	2012	Retention of radionuclide (60)Co(II) from aqueous solution by sorption onto diatomite was investigated by using batch technique under various environmental conditions such as pH, ionic strength, humic acid (HA), fulvic acid (FA), and temperature.	fulvic acid	212-223	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-36
22677879-4	2012	The results indicated that the sorption of Co(II) onto diatomite was strongly dependent on pH.	diatomite	55-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-49
22677879-5	2012	At low pH value, the sorption of Co(II) was dominated by outer-sphere surface complexation and ion exchange with Na(+)/H(+) on diatomite surfaces, whereas inner-sphere surface complexation was the main sorption mechanism at high pH value.	diatomite	127-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-39
22765944-0	2012	Coordination behavior of tetraaza [N4] ligand towards Co(II), Ni(II), Cu(II), Cu(I) and Pd(II) complexes: synthesis, spectroscopic characterization and anticancer activity.	tetraaza [n4	25-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-60
22765944-1	2012	Novel eight Co(II), Ni(II), Cu(II), Cu(I) and Pd(II) complexes with [N(4)] ligand (L) i.e. 2-amino-N-{2-[(2-aminobenzoyl)amino]ethyl}benzamide have been synthesized and structurally characterized by elemental analysis, spectral, thermal (TG/DTG), magnetic, and molar conductivity measurements.	Polydioxanone	46-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-18
22765944-1	2012	Novel eight Co(II), Ni(II), Cu(II), Cu(I) and Pd(II) complexes with [N(4)] ligand (L) i.e. 2-amino-N-{2-[(2-aminobenzoyl)amino]ethyl}benzamide have been synthesized and structurally characterized by elemental analysis, spectral, thermal (TG/DTG), magnetic, and molar conductivity measurements.	Folic Acid	69-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-18
22765944-1	2012	Novel eight Co(II), Ni(II), Cu(II), Cu(I) and Pd(II) complexes with [N(4)] ligand (L) i.e. 2-amino-N-{2-[(2-aminobenzoyl)amino]ethyl}benzamide have been synthesized and structurally characterized by elemental analysis, spectral, thermal (TG/DTG), magnetic, and molar conductivity measurements.	Benzamide, N,N'-1,2-ethanediylbis[2-amino-	91-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-18
22765944-2	2012	On the basis of IR, mass, electronic and EPR spectral studies an octahedral geometry has been proposed for Co(II), Ni(II) complexes and Cu(II) chloride complex, square-pyramidal for Cu(I) bromide complex.	cu(i) bromide	182-195	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-113
23181530-2	2012	Local estrogen production hastens prostaglandin synthesis by stimulating COX-2 activity, thus creating a self-perpetuating sequence of augmented estrogen formation and enhanced inflammation.	Prostaglandins	34-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-78
22959476-2	2012	At pH=3 and a PAN concentration of 0.285 mmol kg(-1), both ATPS lead to the effective separation of Cu(II) from other metallic ions (Zn(II), Co(II), Ni(II) and Fe(III)).	atps	59-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	141-147
22960784-1	2012	The structural, spectroscopic, redox properties and also the reactivity toward S-alkylation of a new mononuclear N2S2 dithiolate Co(II) complex [CoL] (1), with H(2)L = 2,2"-(2,2"-bipyridine-6,6"-diyl)bis(1,1-diphenylethanethiol), have been investigated.	h(2)l	160-165	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-135
22960784-1	2012	The structural, spectroscopic, redox properties and also the reactivity toward S-alkylation of a new mononuclear N2S2 dithiolate Co(II) complex [CoL] (1), with H(2)L = 2,2"-(2,2"-bipyridine-6,6"-diyl)bis(1,1-diphenylethanethiol), have been investigated.	2,2"-(2,2"-bipyridine-6,6"-diyl)bis(1,1-diphenylethanethiol	168-227	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-135
22960784-2	2012	The X-ray structure of 1 has revealed an unusual distorted square planar geometry for a Co(II) ion within a thiolate environment.	thiolate	108-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-94
22960784-8	2012	The cyclic voltammogram (CV) displays two one-electron metal based processes: a quasi-reversible Co(III)/Co(II) oxidation wave at E(1/2) = -0.5 V vs. Fc(+)/Fc and a quasi-reversible Co(II)/Co(I) reduction wave at E(1/2) = -1.7 V. 1 reacts with CH(3)I, generating the mono S-methylated complex, [CoL(Me)I] (1(Me)).	Metals	55-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
22960784-8	2012	The cyclic voltammogram (CV) displays two one-electron metal based processes: a quasi-reversible Co(III)/Co(II) oxidation wave at E(1/2) = -0.5 V vs. Fc(+)/Fc and a quasi-reversible Co(II)/Co(I) reduction wave at E(1/2) = -1.7 V. 1 reacts with CH(3)I, generating the mono S-methylated complex, [CoL(Me)I] (1(Me)).	Metals	55-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-111
22960784-8	2012	The cyclic voltammogram (CV) displays two one-electron metal based processes: a quasi-reversible Co(III)/Co(II) oxidation wave at E(1/2) = -0.5 V vs. Fc(+)/Fc and a quasi-reversible Co(II)/Co(I) reduction wave at E(1/2) = -1.7 V. 1 reacts with CH(3)I, generating the mono S-methylated complex, [CoL(Me)I] (1(Me)).	NAD	189-194	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
22960784-8	2012	The cyclic voltammogram (CV) displays two one-electron metal based processes: a quasi-reversible Co(III)/Co(II) oxidation wave at E(1/2) = -0.5 V vs. Fc(+)/Fc and a quasi-reversible Co(II)/Co(I) reduction wave at E(1/2) = -1.7 V. 1 reacts with CH(3)I, generating the mono S-methylated complex, [CoL(Me)I] (1(Me)).	NAD	189-194	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-111
22960784-8	2012	The cyclic voltammogram (CV) displays two one-electron metal based processes: a quasi-reversible Co(III)/Co(II) oxidation wave at E(1/2) = -0.5 V vs. Fc(+)/Fc and a quasi-reversible Co(II)/Co(I) reduction wave at E(1/2) = -1.7 V. 1 reacts with CH(3)I, generating the mono S-methylated complex, [CoL(Me)I] (1(Me)).	Mono-S	267-273	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
22960784-8	2012	The cyclic voltammogram (CV) displays two one-electron metal based processes: a quasi-reversible Co(III)/Co(II) oxidation wave at E(1/2) = -0.5 V vs. Fc(+)/Fc and a quasi-reversible Co(II)/Co(I) reduction wave at E(1/2) = -1.7 V. 1 reacts with CH(3)I, generating the mono S-methylated complex, [CoL(Me)I] (1(Me)).	Mono-S	267-273	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-111
23045674-2	2012	It is widely believed that COX-2 drives prostacyclin production and that this explains the cardiovascular toxicity associated with COX-2 inhibition, yet the evidence for this relies on indirect evidence from urinary metabolites.	Epoprostenol	40-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-32
23045674-5	2012	With the idea that COX-2 in endothelium drives prostacyclin production in healthy individuals removed, we must seek new answers to why COX-2 inhibitors increase the risk of cardiovascular events to move forward with drug discovery and to enable more informed prescribing advice.	Epoprostenol	47-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-24
22857013-15	2012	The reversible intra- or intermolecular Co-O bond formation and dissociation helps to stabilize the active Co(III) species against reversion to the inactive Co(II) ion.	carboxyl radical	40-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	157-163
22885878-0	2012	The role of the bridging group in exchange coupling in dinuclear homo- and heterometallic Ni(II) and Co(II) complexes with oxalate, oxamidate and dithiooxamidate bridges.	Oxalates	123-130	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-107
22939091-3	2012	Content of Fe(2+)S on nFeS surface decreased (45.9-14.5%) as Fe(2+)S was oxidized to Fe(3+)S and Fe(3+)O coupled with the surface reduction of Co(III) to cobalamin(II) (Co(II)).	ammonium ferrous sulfate	11-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	169-175
22939091-3	2012	Content of Fe(2+)S on nFeS surface decreased (45.9-14.5%) as Fe(2+)S was oxidized to Fe(3+)S and Fe(3+)O coupled with the surface reduction of Co(III) to cobalamin(II) (Co(II)).	nfes	22-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	169-175
22939091-3	2012	Content of Fe(2+)S on nFeS surface decreased (45.9-14.5%) as Fe(2+)S was oxidized to Fe(3+)S and Fe(3+)O coupled with the surface reduction of Co(III) to cobalamin(II) (Co(II)).	ammonium ferrous sulfate	61-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	169-175
22939091-4	2012	S(2-) and S(n)(2-) contents on the nFeS surface also decreased by 48.5% and 82.3%, respectively during the formation of sulfidecobalamin(II) ( S(2-)Co(II)) by the reactive surface sulfur.	nfes	35-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	148-154
22939091-4	2012	S(2-) and S(n)(2-) contents on the nFeS surface also decreased by 48.5% and 82.3%, respectively during the formation of sulfidecobalamin(II) ( S(2-)Co(II)) by the reactive surface sulfur.	sulfidecobalamin(ii)	120-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	148-154
22950081-1	2012	2-D NCS-bridged {3d-4d} molecule-based magnets, formed by reaction of [Mo(III)(NCS)(6)](3-) with either Ni(II) or Co(II) complexes, have been found to exhibit magnetic ordering with T(C) = 39 K for {Co(3)Mo(2)} while {Ni(3)Mo(2)} has a non-magnetic ground state as a result of exact compensation by the individual sub-lattices.	co(3)mo	199-206	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-120
22935655-0	2012	Directed assembly of nanoscale Co(II)-substituted {Co9[P2W15]3} and {Co14[P2W15]4} polyoxometalates.	co9[p2w15]3	51-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-36
22935655-0	2012	Directed assembly of nanoscale Co(II)-substituted {Co9[P2W15]3} and {Co14[P2W15]4} polyoxometalates.	{co14[p2w15]4} polyoxometalates	68-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-36
22935655-1	2012	Herein we report two structurally intriguing Co(ii)-substituted polyoxometalates, a {Co(9)[P(2)W(15)](3)} and {Co(14)[P(2)W(15)](4)} (compounds 1 and 2) that are formed from the same building blocks under subtly different conditions.	polyoxometalate I	64-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-50
22935655-1	2012	Herein we report two structurally intriguing Co(ii)-substituted polyoxometalates, a {Co(9)[P(2)W(15)](3)} and {Co(14)[P(2)W(15)](4)} (compounds 1 and 2) that are formed from the same building blocks under subtly different conditions.	co(9)	85-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-50
22935655-1	2012	Herein we report two structurally intriguing Co(ii)-substituted polyoxometalates, a {Co(9)[P(2)W(15)](3)} and {Co(14)[P(2)W(15)](4)} (compounds 1 and 2) that are formed from the same building blocks under subtly different conditions.	co(14)	111-117	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-50
22998407-5	2012	Water binds to [Co(II)MST](-) to form the five-coordinate [Co(II)MST(OH(2))](-) complex that was used to prepare the Co(II)/Ca(II) complex [Co(II)MST(mu-OH(2))Ca(II) 15-crown-5(OH(2))](+) ([Co(II)(mu-OH(2))Ca(II)OH(2)](+)).	mu-oh	150-155	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
22998407-5	2012	Water binds to [Co(II)MST](-) to form the five-coordinate [Co(II)MST(OH(2))](-) complex that was used to prepare the Co(II)/Ca(II) complex [Co(II)MST(mu-OH(2))Ca(II) 15-crown-5(OH(2))](+) ([Co(II)(mu-OH(2))Ca(II)OH(2)](+)).	Water	153-159	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
22998407-5	2012	Water binds to [Co(II)MST](-) to form the five-coordinate [Co(II)MST(OH(2))](-) complex that was used to prepare the Co(II)/Ca(II) complex [Co(II)MST(mu-OH(2))Ca(II) 15-crown-5(OH(2))](+) ([Co(II)(mu-OH(2))Ca(II)OH(2)](+)).	Water	153-159	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
22998407-5	2012	Water binds to [Co(II)MST](-) to form the five-coordinate [Co(II)MST(OH(2))](-) complex that was used to prepare the Co(II)/Ca(II) complex [Co(II)MST(mu-OH(2))Ca(II) 15-crown-5(OH(2))](+) ([Co(II)(mu-OH(2))Ca(II)OH(2)](+)).	mu-oh	197-202	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
22998407-5	2012	Water binds to [Co(II)MST](-) to form the five-coordinate [Co(II)MST(OH(2))](-) complex that was used to prepare the Co(II)/Ca(II) complex [Co(II)MST(mu-OH(2))Ca(II) 15-crown-5(OH(2))](+) ([Co(II)(mu-OH(2))Ca(II)OH(2)](+)).	mu-oh	197-202	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
22998407-5	2012	Water binds to [Co(II)MST](-) to form the five-coordinate [Co(II)MST(OH(2))](-) complex that was used to prepare the Co(II)/Ca(II) complex [Co(II)MST(mu-OH(2))Ca(II) 15-crown-5(OH(2))](+) ([Co(II)(mu-OH(2))Ca(II)OH(2)](+)).	ca(ii)oh	206-214	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
22998407-5	2012	Water binds to [Co(II)MST](-) to form the five-coordinate [Co(II)MST(OH(2))](-) complex that was used to prepare the Co(II)/Ca(II) complex [Co(II)MST(mu-OH(2))Ca(II) 15-crown-5(OH(2))](+) ([Co(II)(mu-OH(2))Ca(II)OH(2)](+)).	ca(ii)oh	206-214	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
22998407-6	2012	[Co(II)(mu-OH(2))CaOH(2)](+) contained two aquo ligands, one bonded to the Ca(II) ion and one bridging between the two metal ions, and thus represents an unusual example of a heterobimetallic complex containing two aquo ligands spanning different metal ions.	mu-oh(2))caoh(2)	8-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	1-7
22998407-6	2012	[Co(II)(mu-OH(2))CaOH(2)](+) contained two aquo ligands, one bonded to the Ca(II) ion and one bridging between the two metal ions, and thus represents an unusual example of a heterobimetallic complex containing two aquo ligands spanning different metal ions.	Metals	119-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	1-7
22998407-6	2012	[Co(II)(mu-OH(2))CaOH(2)](+) contained two aquo ligands, one bonded to the Ca(II) ion and one bridging between the two metal ions, and thus represents an unusual example of a heterobimetallic complex containing two aquo ligands spanning different metal ions.	Metals	183-188	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	1-7
22998407-10	2012	Allowing [Co(III)(mu-OH)Ca(II)](+) to react with diphenylhydrazine afforded [Co(II)(mu-OH(2))Ca(II)OH(2)](+) and azobenzene.	co(iii)	10-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-83
22998407-10	2012	Allowing [Co(III)(mu-OH)Ca(II)](+) to react with diphenylhydrazine afforded [Co(II)(mu-OH(2))Ca(II)OH(2)](+) and azobenzene.	mu-oh	18-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-83
22998407-10	2012	Allowing [Co(III)(mu-OH)Ca(II)](+) to react with diphenylhydrazine afforded [Co(II)(mu-OH(2))Ca(II)OH(2)](+) and azobenzene.	1,2-diphenylhydrazine	49-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-83
22998407-10	2012	Allowing [Co(III)(mu-OH)Ca(II)](+) to react with diphenylhydrazine afforded [Co(II)(mu-OH(2))Ca(II)OH(2)](+) and azobenzene.	mu-oh(2))ca(ii)oh(2)	84-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-83
22998407-10	2012	Allowing [Co(III)(mu-OH)Ca(II)](+) to react with diphenylhydrazine afforded [Co(II)(mu-OH(2))Ca(II)OH(2)](+) and azobenzene.	azobenzene	113-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-83
22885878-0	2012	The role of the bridging group in exchange coupling in dinuclear homo- and heterometallic Ni(II) and Co(II) complexes with oxalate, oxamidate and dithiooxamidate bridges.	oxamidate	132-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-107
22885878-0	2012	The role of the bridging group in exchange coupling in dinuclear homo- and heterometallic Ni(II) and Co(II) complexes with oxalate, oxamidate and dithiooxamidate bridges.	dithiooxamidate	146-161	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-107
22670565-0	2012	Nitric oxide augments oridonin-induced efferocytosis by human histocytic lymphoma U937 cells via autophagy and the NF-kappaB-COX-2-IL-1beta pathway.	Nitric Oxide	0-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-130
22758658-5	2012	METHODS: The effect of the PPI esomeprazole on COX-1 and COX-2 mRNA levels in oesophageal cells was determined.	Esomeprazole	31-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-62
22758658-7	2012	RESULTS: COX-2, but not COX-1, mRNA levels dose-dependently increased in OE33 and HET-1A cells versus esomeprazole concentration.	Esomeprazole	102-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	9-14
22758658-9	2012	CONCLUSIONS: Exposure to esomeprazole increases COX-2 mRNA in oesophageal cells.	Esomeprazole	25-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-53
22901457-0	2012	Acyl chain-dependent effect of lysophosphatidylcholine on cyclooxygenase (COX)-2 expression in endothelial cells.	Lysophosphatidylcholines	31-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-80
22901457-3	2012	METHODS &amp; RESULTS: LPC 16:0 and 20:4 promoted both COX-2 mRNA- and protein synthesis with different potencies and kinetics.	Adenosine Monophosphate	9-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-60
22849544-2	2012	The lead molecule of these compounds was nimesulide (4-nitro-2-phenoxymethane-sulfoanilide), a cyclooxygenase (COX) inhibitor acting on both COX-1 and 2 isoforms, with some selectivity for COX-2.	nimesulide	41-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	189-194
22849544-2	2012	The lead molecule of these compounds was nimesulide (4-nitro-2-phenoxymethane-sulfoanilide), a cyclooxygenase (COX) inhibitor acting on both COX-1 and 2 isoforms, with some selectivity for COX-2.	4-nitro-2-phenoxymethane-sulfoanilide	53-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	189-194
23125582-1	2012	In the title compound, [Co(CH(3)CO(2))(C(18)H(24)N(6))]PF(6), the Co(II) atom is penta-coordinated in a distorted trigonal-bipyramidal geometry by four N atoms from a tripodal ligand and one O atom from a monodentate acetate ligand.	co(ch(3)co(2))	24-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-72
23125582-1	2012	In the title compound, [Co(CH(3)CO(2))(C(18)H(24)N(6))]PF(6), the Co(II) atom is penta-coordinated in a distorted trigonal-bipyramidal geometry by four N atoms from a tripodal ligand and one O atom from a monodentate acetate ligand.	Carbon	39-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-72
23125582-1	2012	In the title compound, [Co(CH(3)CO(2))(C(18)H(24)N(6))]PF(6), the Co(II) atom is penta-coordinated in a distorted trigonal-bipyramidal geometry by four N atoms from a tripodal ligand and one O atom from a monodentate acetate ligand.	)h(24)n(6))]pf	43-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-72
23125582-1	2012	In the title compound, [Co(CH(3)CO(2))(C(18)H(24)N(6))]PF(6), the Co(II) atom is penta-coordinated in a distorted trigonal-bipyramidal geometry by four N atoms from a tripodal ligand and one O atom from a monodentate acetate ligand.	Nitrogen	49-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-72
23125582-1	2012	In the title compound, [Co(CH(3)CO(2))(C(18)H(24)N(6))]PF(6), the Co(II) atom is penta-coordinated in a distorted trigonal-bipyramidal geometry by four N atoms from a tripodal ligand and one O atom from a monodentate acetate ligand.	Acetates	217-224	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-72
22890064-6	2012	A clinical trial showed that celecoxib, a cyclooxygenase (COX)-2 inhibitor, significantly reduced the number of colorectal polyps in children with familial adenomatous polyposis (FAP).	Celecoxib	29-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-64
22670565-0	2012	Nitric oxide augments oridonin-induced efferocytosis by human histocytic lymphoma U937 cells via autophagy and the NF-kappaB-COX-2-IL-1beta pathway.	oridonin	22-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-130
22670565-8	2012	1400 W or L-NAME blocked the secretion of IL-1beta and the activation of NF-kappaB and COX-2.	NG-Nitroarginine Methyl Ester	10-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-92
22670565-10	2012	NO augmented the oridonin-induced efferocytosis by mediating autophagy and activating the NF-kappaB-COX-2-IL-1beta pathway.	oridonin	17-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-105
22985442-7	2012	In the formation of 2-6, two Tab ligands are removed from the [Zn(Tab)(4)](2+) dication when it is attacked by L ligands, while in the cases of 7-9, the Zn(II) of the [Zn(Tab)(4)](2+) dication was replaced by Co(III) (derived from oxidation of Co(II) by O(2)) followed by the removal of two Tab ligands via L ligands.	Zinc	153-159	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	209-214
22985442-7	2012	In the formation of 2-6, two Tab ligands are removed from the [Zn(Tab)(4)](2+) dication when it is attacked by L ligands, while in the cases of 7-9, the Zn(II) of the [Zn(Tab)(4)](2+) dication was replaced by Co(III) (derived from oxidation of Co(II) by O(2)) followed by the removal of two Tab ligands via L ligands.	Zinc	63-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	209-214
22985442-8	2012	In the case of 10, the central Zn(II) of the [Zn(Tab)(4)](2+) dication was displaced by Co(II) followed by the removal of three Tab ligands via one Cl(-) and one tridentate bdmppy.	Zinc	31-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-94
22985442-8	2012	In the case of 10, the central Zn(II) of the [Zn(Tab)(4)](2+) dication was displaced by Co(II) followed by the removal of three Tab ligands via one Cl(-) and one tridentate bdmppy.	zn(tab)(4)	46-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-94
22955517-9	2012	In contrast, MAT increased significantly COX-2-derived prostaglandin E(2) in confluent cells.	Dinoprostone	55-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-46
22895552-3	2012	Relatively high levels of COX-2 mRNA and its product PGE2 were observed only in PC-3 cells and their xenografts.	Dinoprostone	53-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-31
22899448-5	2012	Although ROS can increase expression of COX-2 mRNA, an inflammatory marker, laser-induced COX-2 expression was significantly suppressed by the antioxidant activity of fullerene.	Reactive Oxygen Species	9-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
22507555-6	2012	SIRT1 inhibition by sirtinol or Sirt1 siRNA reversed the effects of melatonin on H(2) O(2) -mediated induction of pro-inflammatory cytokines (NO, PGE(2) , TNF-alpha, IL-1beta, and IL-8) and the expression of iNOS, COX-2, and cartilage destruction molecules.	Melatonin	68-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	214-219
22507555-4	2012	Melatonin markedly inhibited hydrogen peroxide (H(2) O(2) )-stimulated cytotoxicity, iNOS, and COX-2 protein and mRNA expression, as well as the downstream products, NO and PGE(2) .	Melatonin	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-100
22507555-4	2012	Melatonin markedly inhibited hydrogen peroxide (H(2) O(2) )-stimulated cytotoxicity, iNOS, and COX-2 protein and mRNA expression, as well as the downstream products, NO and PGE(2) .	Hydrogen Peroxide	29-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-100
22507555-4	2012	Melatonin markedly inhibited hydrogen peroxide (H(2) O(2) )-stimulated cytotoxicity, iNOS, and COX-2 protein and mRNA expression, as well as the downstream products, NO and PGE(2) .	Hydrogen Peroxide	48-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-100
22899448-5	2012	Although ROS can increase expression of COX-2 mRNA, an inflammatory marker, laser-induced COX-2 expression was significantly suppressed by the antioxidant activity of fullerene.	Reactive Oxygen Species	9-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-95
22899448-5	2012	Although ROS can increase expression of COX-2 mRNA, an inflammatory marker, laser-induced COX-2 expression was significantly suppressed by the antioxidant activity of fullerene.	Fullerenes	167-176	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
22899448-5	2012	Although ROS can increase expression of COX-2 mRNA, an inflammatory marker, laser-induced COX-2 expression was significantly suppressed by the antioxidant activity of fullerene.	Fullerenes	167-176	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-95
22902539-9	2012	Furthermore, OXT-dependent transcription was dependent on protein neosynthesis; cycloheximide abolished RGS2 transcription but augmented RCAN1 and COX2 transcriptional readouts.	Cycloheximide	80-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-151
23090376-5	2012	However, this exclusive COX-2 inhibition was associated with serious cardiovascular events, for causing an imbalance between prostacyclin and thromboxane production.	Epoprostenol	125-137	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
22652293-4	2012	We also report that COX-2-silenced cells have reduced nuclear accumulation of LEF-1 protein and that the COX-2 product PGE(2) partially restored nuclear LEF-1 expression in COX-2-silenced cells.	Dinoprostone	119-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-110
22652293-4	2012	We also report that COX-2-silenced cells have reduced nuclear accumulation of LEF-1 protein and that the COX-2 product PGE(2) partially restored nuclear LEF-1 expression in COX-2-silenced cells.	Dinoprostone	119-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-110
22743741-5	2012	The HCA2-mediated flushing response to these drugs involves the formation of prostaglandins D2 and E2 by Langerhans cells and keratinocytes via COX-1 in Langerhans cells and COX-2 in keratinocytes.	Prostaglandin D2	77-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	174-179
22743741-5	2012	The HCA2-mediated flushing response to these drugs involves the formation of prostaglandins D2 and E2 by Langerhans cells and keratinocytes via COX-1 in Langerhans cells and COX-2 in keratinocytes.	Estradiol	99-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	174-179
23090376-5	2012	However, this exclusive COX-2 inhibition was associated with serious cardiovascular events, for causing an imbalance between prostacyclin and thromboxane production.	Thromboxanes	142-153	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
22771391-0	2012	Modulation of NF-kappaB activation by resveratrol in LPS treated human intestinal cells results in downregulation of PGE2 production and COX-2 expression.	Resveratrol	38-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-142
22935596-0	2012	Synthesis, characterization, equilibrium study and biological activity of Cu(II), Ni(II) and Co(II) complexes of polydentate Schiff base ligand.	cu(ii)	74-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-99
22935596-0	2012	Synthesis, characterization, equilibrium study and biological activity of Cu(II), Ni(II) and Co(II) complexes of polydentate Schiff base ligand.	Schiff Bases	125-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-99
22935596-1	2012	Schiff base ligand, 1,4-bis[(2-hydroxybenzaldehyde)propyl]piperazine (BHPP), and its Cu(II), Ni(II) and Co(II) metal complexes were synthesized and characterized by elemental analysis, magnetic susceptibility, molar conductance and spectral (IR and UV-vis) studies.	Schiff Bases	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-110
22935596-1	2012	Schiff base ligand, 1,4-bis[(2-hydroxybenzaldehyde)propyl]piperazine (BHPP), and its Cu(II), Ni(II) and Co(II) metal complexes were synthesized and characterized by elemental analysis, magnetic susceptibility, molar conductance and spectral (IR and UV-vis) studies.	1,4-bis[(2-hydroxybenzaldehyde)propyl]piperazine	20-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-110
22935596-1	2012	Schiff base ligand, 1,4-bis[(2-hydroxybenzaldehyde)propyl]piperazine (BHPP), and its Cu(II), Ni(II) and Co(II) metal complexes were synthesized and characterized by elemental analysis, magnetic susceptibility, molar conductance and spectral (IR and UV-vis) studies.	bhpp	70-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-110
22935596-1	2012	Schiff base ligand, 1,4-bis[(2-hydroxybenzaldehyde)propyl]piperazine (BHPP), and its Cu(II), Ni(II) and Co(II) metal complexes were synthesized and characterized by elemental analysis, magnetic susceptibility, molar conductance and spectral (IR and UV-vis) studies.	Metals	111-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-110
22935596-3	2012	Metal complexes are formed in the 1:1 (M:L) ratio as found from the elemental analysis and found to have the general formula [ML] nH(2)O, where M=Co(II), Ni(II) and Cu(II), L=BHPP.	Metals	0-5	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	146-152
22771391-3	2012	Here we evaluated the effect of resveratrol on COX-2 and prostaglandin E(2) production in human intestinal cells Caco-2 cells treated with lipopolysaccharide (LPS).	Resveratrol	32-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
22771391-4	2012	Resveratrol concentration-dependently inhibited the expression of COX-2 mRNA in the LPS-treated cells, as well as protein expression, resulting in a decreased production of PGE(2).	Resveratrol	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-71
22771391-7	2012	These results suggest that the down-regulation of COX-2 and PGE(2) by resveratrol may be related to NF-kappaB inhibition through the negative regulation of IKK phosphorylation in intestinal cells.	Resveratrol	70-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-55
23114124-0	2012	[Effects of COX-2 inhibitor celecoxib on expressions of VEGF, b-FGF and TGF-beta mRNA in acute leukemia cells].	Celecoxib	28-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-17
23114124-6	2012	It is concluded that COX-2 inhibitor celecoxib can inhabit vascular endothelial growth through down-regulating the mRNA expression of VEGF, b-FGF and TGF-beta in acute leukemia cells.	Celecoxib	37-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-26
23270246-9	2012	But as for inhibitors NSAIDS and COX-2 for oral,the adverse effect rate of the TCMG was lower than that of the WMG [(1.07% (4/375): 15.46% (45/291)], OR = 0.11 [0.01-0.87], Z = 2.09 (P = 0.04).	tcmg	79-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-38
23369567-3	2012	We observed that PGE2 induces endogenous cyclooxygenase (COX)2 expression in cultured monocytes, blocking their differentiation into CD1a+ dendritic cells (DCs) and inducing the expression of indoleamine 2,3-dioxygenase 1, IL-4Ralpha, nitric oxide synthase 2 and IL-10 - typical MDSC-associated suppressive factors.	Dinoprostone	17-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-62
23369567-4	2012	The establishment of a positive feedback loop between PGE2 and COX2, the key regulator of PGE2 synthesis, is both necessary and sufficient to promote the development of CD1a+ DCs to CD14+CD33+CD34+ monocytic MDSCs in granulocyte macrophage colony stimulating factor/IL-4-supplemented monocyte cultures, their stability, production of multiple immunosuppressive mediators and cytotoxic T lymphocyte-suppressive function.	Dinoprostone	90-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-67
22931346-0	2012	Structure and magnetism of Sr3Co2O4Cl2--an electronically driven lattice distortion in an oxychloride containing square planar Co(II) centers.	sr3co2o4cl2	27-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	127-133
22728235-1	2012	Binuclear Cu(II), Co(II) and Ni(II) complexes derived from N(1)-ethyl-N(2)-(pyridin-2-yl) hydrazine-1,2-bis(carbothioamide) (H(2)PET) have been prepared and characterized by elemental analysis, spectral (IR, UV-vis, EI mass, ESR and (1)HNMR) and magnetic measurements.	n(1)-ethyl-n(2)-(pyridin-2-yl) hydrazine-1,2-bis(carbothioamide)	59-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-24
22728235-3	2012	IR data revealed that the ligand behaves as monobasic tridentate through (CN)(py), (C-S) and new azomethine, (NC)(*) groups in the Co(II) complex but in Cu(II) complex, the ligand coordinate via both (CS) groups, one of them in thiol form as well as the new azomethine group.	Cesium	84-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-137
22728235-3	2012	IR data revealed that the ligand behaves as monobasic tridentate through (CN)(py), (C-S) and new azomethine, (NC)(*) groups in the Co(II) complex but in Cu(II) complex, the ligand coordinate via both (CS) groups, one of them in thiol form as well as the new azomethine group.	azomethine	97-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-137
22728235-3	2012	IR data revealed that the ligand behaves as monobasic tridentate through (CN)(py), (C-S) and new azomethine, (NC)(*) groups in the Co(II) complex but in Cu(II) complex, the ligand coordinate via both (CS) groups, one of them in thiol form as well as the new azomethine group.	cu(ii)	153-159	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-137
22728235-3	2012	IR data revealed that the ligand behaves as monobasic tridentate through (CN)(py), (C-S) and new azomethine, (NC)(*) groups in the Co(II) complex but in Cu(II) complex, the ligand coordinate via both (CS) groups, one of them in thiol form as well as the new azomethine group.	Cesium	201-203	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-137
22728235-3	2012	IR data revealed that the ligand behaves as monobasic tridentate through (CN)(py), (C-S) and new azomethine, (NC)(*) groups in the Co(II) complex but in Cu(II) complex, the ligand coordinate via both (CS) groups, one of them in thiol form as well as the new azomethine group.	Sulfhydryl Compounds	228-233	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-137
22728235-3	2012	IR data revealed that the ligand behaves as monobasic tridentate through (CN)(py), (C-S) and new azomethine, (NC)(*) groups in the Co(II) complex but in Cu(II) complex, the ligand coordinate via both (CS) groups, one of them in thiol form as well as the new azomethine group.	azomethine	258-268	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-137
22931346-0	2012	Structure and magnetism of Sr3Co2O4Cl2--an electronically driven lattice distortion in an oxychloride containing square planar Co(II) centers.	Chlorine monoxide	90-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	127-133
22992293-7	2012	Despite this, our data also indicate that AST could attenuate cobalt chloride-evoked COX-2 activation, while such effect on COX-2 and its downstream target VEGF was intensified when indomethacin was concurrently treated.	cobaltous chloride	62-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-90
22954257-5	2012	One fewer sulfur atom is protonated in the Co(II)(mnt)(2) complex than in the other three complexes in the series.	Sulfur	10-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-49
22992293-7	2012	Despite this, our data also indicate that AST could attenuate cobalt chloride-evoked COX-2 activation, while such effect on COX-2 and its downstream target VEGF was intensified when indomethacin was concurrently treated.	Indomethacin	182-194	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	124-129
22829202-0	2012	Apricoxib, a novel inhibitor of COX-2, markedly improves standard therapy response in molecularly defined models of pancreatic cancer.	apricoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-37
22819703-4	2012	However, synthetic NSAIDs are less potent than steroids, have limited formulation flexibility and have their own safety issues, thereby yielding unsatisfactory results, with some high-profile drugs (e.g., the COX-2 inhibitors Vioxx, Celebrex) being withdrawn from the market due to safety concerns.	rofecoxib	226-231	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	209-214
22829202-5	2012	Here, we report that apricoxib, a novel COX-2 inhibitor in phase II clinical trials, significantly enhances the efficacy of gemcitabine/erlotinib in preclinical models of pancreatic cancer.	apricoxib	21-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
22829202-9	2012	RESULTS: COX-2 inhibition reduced the IC(50) of gemcitabine +- erlotinib in six pancreatic cancer cell lines tested in vitro.	gemcitabine	48-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	9-14
22829202-9	2012	RESULTS: COX-2 inhibition reduced the IC(50) of gemcitabine +- erlotinib in six pancreatic cancer cell lines tested in vitro.	Erlotinib Hydrochloride	63-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	9-14
22829202-11	2012	In vivo apricoxib combination therapy was only effective at reducing tumor growth and metastasis in tumors with elevated COX-2 activity.	apricoxib	8-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-126
22829202-12	2012	In each model examined, treatment with apricoxib resulted in vascular normalization without a decrease in microvessel density and promotion of an epithelial phenotype by tumor cells regardless of basal COX-2 expression.	apricoxib	39-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	202-207
22924695-1	2012	Activation of the corrinoid [Fe-S] protein (CoFeSP), involved in reductive CO(2) conversion, requires the reduction of the Co(II) center by the [Fe-S] protein RACo, which according to the reduction potentials of the two proteins would correspond to an uphill electron transfer.	Corrinoids	18-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-129
22822059-1	2012	Arachidonic acid is converted to prostaglandin E(2) (PGE(2)) by a sequential enzymatic reaction performed by two isoenzyme groups, cyclooxygenases (COX-1 and COX-2) and terminal prostaglandin E synthases (cPGES, mPGES-1, and mPGES-2).	Arachidonic Acid	0-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	158-163
22822059-1	2012	Arachidonic acid is converted to prostaglandin E(2) (PGE(2)) by a sequential enzymatic reaction performed by two isoenzyme groups, cyclooxygenases (COX-1 and COX-2) and terminal prostaglandin E synthases (cPGES, mPGES-1, and mPGES-2).	Dinoprostone	33-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	158-163
22822059-1	2012	Arachidonic acid is converted to prostaglandin E(2) (PGE(2)) by a sequential enzymatic reaction performed by two isoenzyme groups, cyclooxygenases (COX-1 and COX-2) and terminal prostaglandin E synthases (cPGES, mPGES-1, and mPGES-2).	Prostaglandins E	53-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	158-163
22822059-2	2012	mPGES-1 is widely considered to be the final enzyme regulating COX-2-dependent PGE(2) synthesis.	Dinoprostone	79-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-68
22824620-0	2012	Sodium arsenite-induced abnormalities in expressions of Caveolin-1, eNOS, IKKbeta, and COX-2 in SV-40 immortalized human uroepithelial cells and in urothelial carcinomas.	sodium arsenite	0-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-92
22824620-5	2012	Immunocytochemical staining and Western blotting results revealed increased expression of Caveolin-1, IKKbeta, and COX-2 but decreased eNOS in SV-HUC-1 cells treated with low concentration of arsenite.	arsenite	192-200	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-120
22824620-6	2012	Additionally, MEK inhibitor (U0126) significantly attenuated arsenite-induced expression of Caveolin-1, IKKbeta and COX-2 while reducing eNOS expression.	U 0126	29-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-121
22824620-6	2012	Additionally, MEK inhibitor (U0126) significantly attenuated arsenite-induced expression of Caveolin-1, IKKbeta and COX-2 while reducing eNOS expression.	arsenite	61-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-121
22810276-3	2012	Co(II) is hepta-coordinated by three N atoms from the bpy units, and four O atoms from two nitrate groups.	Nitrates	91-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
22924695-1	2012	Activation of the corrinoid [Fe-S] protein (CoFeSP), involved in reductive CO(2) conversion, requires the reduction of the Co(II) center by the [Fe-S] protein RACo, which according to the reduction potentials of the two proteins would correspond to an uphill electron transfer.	Iron	29-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-129
22924695-1	2012	Activation of the corrinoid [Fe-S] protein (CoFeSP), involved in reductive CO(2) conversion, requires the reduction of the Co(II) center by the [Fe-S] protein RACo, which according to the reduction potentials of the two proteins would correspond to an uphill electron transfer.	co(2)	75-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-129
22887038-0	2012	Reversible crystal-to-amorphous structural conversion in the single end-on azide-bridged Co(II) complex: concomitant color and magnetic modulations.	Azides	75-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-95
22924695-2	2012	In our resonance Raman spectroscopic work, we demonstrate that, as a conformational gate for the corrinoid reduction, complex formation of Co(II)FeSP and RACo specifically alters the structure of the corrinoid cofactor by modifying the interactions of the Co(II) center with the axial ligand.	Corrinoids	97-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	256-262
22924695-2	2012	In our resonance Raman spectroscopic work, we demonstrate that, as a conformational gate for the corrinoid reduction, complex formation of Co(II)FeSP and RACo specifically alters the structure of the corrinoid cofactor by modifying the interactions of the Co(II) center with the axial ligand.	Cobalt(2+)	139-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	256-262
22887038-1	2012	Crystal clear: An end-on (EO) azide-bridged Co(II)  layer (see scheme; 1) with coordinated water molecules, long spacer p-XBP4 ligands, and unbound azide anions was evacuated to generate a dehydrated sample of 2.	(eo) azide	25-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-50
22887038-1	2012	Crystal clear: An end-on (EO) azide-bridged Co(II)  layer (see scheme; 1) with coordinated water molecules, long spacer p-XBP4 ligands, and unbound azide anions was evacuated to generate a dehydrated sample of 2.	Water	91-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-50
22924695-2	2012	In our resonance Raman spectroscopic work, we demonstrate that, as a conformational gate for the corrinoid reduction, complex formation of Co(II)FeSP and RACo specifically alters the structure of the corrinoid cofactor by modifying the interactions of the Co(II) center with the axial ligand.	Corrinoids	200-209	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	256-262
22887038-1	2012	Crystal clear: An end-on (EO) azide-bridged Co(II)  layer (see scheme; 1) with coordinated water molecules, long spacer p-XBP4 ligands, and unbound azide anions was evacuated to generate a dehydrated sample of 2.	Azides	30-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-50
22898050-11	2012	Metformin suppressed COX-2 and iNOS mRNA and protein expression dose dependently.	Metformin	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-26
22760243-0	2012	Isopolyoxometalates derived from arylstibonic acids with "reverse-Keggin ion" structures based on [M(RSb)12O28] cores, M = Co(II) or Zn(II).	arylstibonic acids	33-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-129
22889014-0	2012	Terminal and internal olefin epoxidation with cobalt(II) as the catalyst: evidence for an active oxidant Co(II)-acylperoxo species.	Cobalt(2+)	46-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-111
22889014-4	2012	Olefin epoxidation by this catalytic system is proposed to involve a new reactive Co(II)-OOC(O)R species, based on evidence from H(2)(18)O-exchange experiments, the use of peroxyphenylacetic acid as a mechanistic probe, reactivity and Hammett studies, EPR, and ESI-mass spectrometric investigation.	Alkenes	0-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
22889014-4	2012	Olefin epoxidation by this catalytic system is proposed to involve a new reactive Co(II)-OOC(O)R species, based on evidence from H(2)(18)O-exchange experiments, the use of peroxyphenylacetic acid as a mechanistic probe, reactivity and Hammett studies, EPR, and ESI-mass spectrometric investigation.	peroxyphenylacetic acid	172-195	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
22889014-5	2012	However, the O-O bond of a Co(II)-acylperoxo intermediate (Co(II)-OOC(O)R) was found to be cleaved both heterolytically and homolytically if there is no substrate.	acylperoxo	34-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-33
22889014-5	2012	However, the O-O bond of a Co(II)-acylperoxo intermediate (Co(II)-OOC(O)R) was found to be cleaved both heterolytically and homolytically if there is no substrate.	acylperoxo	34-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
22889014-5	2012	However, the O-O bond of a Co(II)-acylperoxo intermediate (Co(II)-OOC(O)R) was found to be cleaved both heterolytically and homolytically if there is no substrate.	ORALIT	69-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-33
22913479-1	2012	A novel, highly efficient, and stable water oxidation catalyst was prepared by a pH-controlled adsorption of Co(II) on ~10 nm diameter silica nanoparticles.	Water	38-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-115
22913479-1	2012	A novel, highly efficient, and stable water oxidation catalyst was prepared by a pH-controlled adsorption of Co(II) on ~10 nm diameter silica nanoparticles.	Silicon Dioxide	135-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-115
22889014-5	2012	However, the O-O bond of a Co(II)-acylperoxo intermediate (Co(II)-OOC(O)R) was found to be cleaved both heterolytically and homolytically if there is no substrate.	ORALIT	69-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
23054721-8	2012	These data indicate that the COX-2 induction by alphaTPGS is mediated through increased ROS generation.	Reactive Oxygen Species	88-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34
22969496-2	2012	The structure consists of columns that contain inter-leaved mol-ecules of NBA and [Co(II)(OEP)] (OEP is 2,3,7,8,12,13,17,18-octa-ethyl-porphyrin), which are stacked along the a axis.	octaethylporphyrin	123-144	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-89
22696602-5	2012	Treatment of CD cells with either cyclooxygenase-1 (COX-1) or COX-2 inhibitors during exposure to FSS limited the increase in PGE(2) concentration to an equal extent, suggesting COX-1 and COX-2 contribute equally to FSS-induced PGE(2) release.	Cadmium	13-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
22696602-5	2012	Treatment of CD cells with either cyclooxygenase-1 (COX-1) or COX-2 inhibitors during exposure to FSS limited the increase in PGE(2) concentration to an equal extent, suggesting COX-1 and COX-2 contribute equally to FSS-induced PGE(2) release.	Cadmium	13-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	188-193
22696602-5	2012	Treatment of CD cells with either cyclooxygenase-1 (COX-1) or COX-2 inhibitors during exposure to FSS limited the increase in PGE(2) concentration to an equal extent, suggesting COX-1 and COX-2 contribute equally to FSS-induced PGE(2) release.	Prostaglandins E	126-129	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
22806885-6	2012	3,5,7-Trihydroxyflavone was able to inhibit both COX-1 and COX-2, which makes it a dual inhibitor of COX and 5-LOX pathways and, therefore, a promising candidate for a new therapeutic option in the treatment of inflammatory processes.	galangin	0-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-64
22433003-9	2012	It was found that licofelone attenuated interleukin-18-induced COX-2 enzyme activity in HMC and prostaglandin E2 release in a dose-dependent manner.	licofelone	18-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-68
22471974-11	2012	KEY RESULTS: Flavocoxid reduced prostate weight and hyperplasia, blunted inducible expression of COX-2 and 5-LOX as well as the increased production of PGE(2)  and leukotriene B(4)  (LTB(4) ), enhanced pro-apoptotic Bax and caspase-9 and decreased the anti-apoptotic Bcl-2 mRNA.	flavocoxid	13-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-108
22814678-10	2012	Western blots revealed that BA directly inhibited the phosphorylation of VEGFR2, followed by inhibiting the activations of its downstream protein kinases, including ERK, p38, FAK, AKT, and expression of iNOS, but had no effect on COX2.	barbigerone	28-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	230-234
22865828-0	2012	Designing multitarget anti-inflammatory agents: chemical modulation of the lumiracoxib structure toward dual thromboxane antagonists-COX-2 inhibitors.	lumiracoxib	75-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	133-138
22763855-8	2012	Here we show that tumor cells are able to elicit a strong induction of the COX-2/microsomal prostaglandin-E synthase-1 (mPGES-1)/PGE(2) axis in MSCs recruited to the tumor-associated stroma by releasing IL-1, which in turn elicits a mesenchymal/stem cell-like phenotype in the carcinoma cells.	Prostaglandins E	121-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
22865828-1	2012	A series of lumiracoxib derivatives were designed to explore the influence of isosteric substitution on balancing COX-2 inhibition and thromboxane A(2)  prostanoid (TP) receptor antagonism.	lumiracoxib	12-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-119
22865828-5	2012	Some of the isosteric substitutions at the carboxylic acid group afforded compounds with improved TP receptor antagonism; of these, a tetrazole derivative retained good COX-2 inhibitory activity and selectivity.	1H-tetrazole	134-143	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	169-174
22348284-3	2012	OBJECTIVE: In this study, meloxicam, which is an enolic acid-type preferential COX-2 inhibitor, was encapsulated in poly(D,L-lactide-co-glycolide) (PLGA) nanoparticles (NPs) to maintain local high concentration, and its efficacy was determined.	Meloxicam	26-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-84
22348284-3	2012	OBJECTIVE: In this study, meloxicam, which is an enolic acid-type preferential COX-2 inhibitor, was encapsulated in poly(D,L-lactide-co-glycolide) (PLGA) nanoparticles (NPs) to maintain local high concentration, and its efficacy was determined.	enolic acid	49-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-84
23047501-8	2012	In addition, sinomenine suppressed COX-2 protein and mRNA expression dose-dependently.	sinomenine	13-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40
23047501-9	2012	CONCLUSIONS: Taken together, the results of this study indicate that the anti-inflammatory effects of sinomenine may occur via the inhibition of pro-inflammatory cytokine and COX-2 production through the inhibition of MAPKs and NF-kappaB pathway activation by PMA plus A23187 stimulation in HMC-1 cells.	sinomenine	102-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	175-180
22486746-10	2012	The mRNA and protein expression of COX-2, along with production of PGE(2) and PGF(2alpha), are drastically raised by 2.5-5 mmol L(-1) TEGDMA.	Prostaglandins E	67-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40
22486746-10	2012	The mRNA and protein expression of COX-2, along with production of PGE(2) and PGF(2alpha), are drastically raised by 2.5-5 mmol L(-1) TEGDMA.	Prostaglandins F	78-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40
22828789-1	2012	Levels of prostaglandin E(2) (PGE(2)) and its processing enzyme, prostaglandin-endoperoxide-synthase-2/ cyclooxygenase-2 (PTGS2/COX-2), are elevated in actively progressing periodontal lesions, but suppressed in chronic disease.	Dinoprostone	10-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	128-133
22546526-8	2012	Moreover, dormant bacilli induced a higher expression of inducible cox-2 gene, accompanied by increased PGE2 secretion.	Dinoprostone	104-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-72
23044772-7	2012	The effect of cations [Ca(II), Mg(II), Co(II), Fe(II) and Cu(II)] was masked online with EDTA.	Edetic Acid	89-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-45
22801352-4	2012	Calcitriol suppresses COX-2 expression and increases that of 15-PGDH thereby reducing the levels of inflammatory prostaglandins (PGs).	Calcitriol	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-27
22608292-0	2012	Synthesis, characterization and quantum chemical ab initio calculations of new dimeric aminocyclodiphosph(V)azane and its Co(II), Ni(II) and Cu(II) complexes.	aminocyclodiphosph	87-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-128
22608292-0	2012	Synthesis, characterization and quantum chemical ab initio calculations of new dimeric aminocyclodiphosph(V)azane and its Co(II), Ni(II) and Cu(II) complexes.	Ammonia	108-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-128
23000759-10	2012	CONCLUSION: Ellagic acid extracted from gallnut has activity against nasopharyngeal carcinoma cells, and its mechanism may be related to down-regulated expression of COX-2 and stathmin.	Ellagic Acid	12-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	166-171
22767361-7	2012	These isomorphous Co(4)RE clusters offer an opportunity to systematically probe the contribution of different metal ions to the overall magnetic behaviour in Co(II)-RE(III) systems.	co(4)	18-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	158-164
22864596-8	2012	When Co(II) ion is replaced by Cu(II) ion, the 3D framework of complex 5 with (4 6(2))(4 6(6) 8(3)) topology based on 3-bpcd and 1,3-BDC ligands is obtained.	cu(ii)	31-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	5-11
22864596-8	2012	When Co(II) ion is replaced by Cu(II) ion, the 3D framework of complex 5 with (4 6(2))(4 6(6) 8(3)) topology based on 3-bpcd and 1,3-BDC ligands is obtained.	3-bpcd	118-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	5-11
22864596-8	2012	When Co(II) ion is replaced by Cu(II) ion, the 3D framework of complex 5 with (4 6(2))(4 6(6) 8(3)) topology based on 3-bpcd and 1,3-BDC ligands is obtained.	3-bdc	131-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	5-11
22803970-1	2012	The synthesis and characterization of the complexes of Cu(I), Ag(I), Cu(II), and Co(II) ions with 1,2,5-selenadiazolopyridine (psd) is reported.	cuprous ion	55-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-86
22885178-0	2012	Stromal COX-2 signaling activated by deoxycholic acid mediates proliferation and invasiveness of colorectal epithelial cancer cells.	Deoxycholic Acid	37-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	8-13
22885178-3	2012	In this article, we investigated whether activation of COX-2 signaling by deoxycholic acid (DCA) in primary human normal and cancer associated fibroblasts play a significant role in regulation of proliferation and invasiveness of colonic epithelial cancer cells.	Deoxycholic Acid	74-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-60
22885178-3	2012	In this article, we investigated whether activation of COX-2 signaling by deoxycholic acid (DCA) in primary human normal and cancer associated fibroblasts play a significant role in regulation of proliferation and invasiveness of colonic epithelial cancer cells.	Deoxycholic Acid	92-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-60
22885178-6	2012	Moreover, COX-2 siRNA attenuated the proliferative and invasive effect of both normal and cancer associate fibroblasts pre-treated with DCA on the colonic cancer cells.	Deoxycholic Acid	136-139	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
22885178-7	2012	Further studies indicated that the activation of COX-2 signaling by DCA is through protein kinase C signaling.	Deoxycholic Acid	68-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-54
22764083-1	2012	Co(II)-substituted alpha-Keggin-type 12-tungstenphosphate [(n-C(4)H(9))(4)N](4)H[PW(11)Co(H(2)O)O(39)]-(PW(11)Co) is synthesized and used as a single-component, solvent-free catalyst in the cycloaddition reaction of CO(2) and epoxides to form cyclic carbonates.	alpha-keggin-type 12-tungstenphosphate	19-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
22764083-1	2012	Co(II)-substituted alpha-Keggin-type 12-tungstenphosphate [(n-C(4)H(9))(4)N](4)H[PW(11)Co(H(2)O)O(39)]-(PW(11)Co) is synthesized and used as a single-component, solvent-free catalyst in the cycloaddition reaction of CO(2) and epoxides to form cyclic carbonates.	Carbon Dioxide	216-221	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
22764083-1	2012	Co(II)-substituted alpha-Keggin-type 12-tungstenphosphate [(n-C(4)H(9))(4)N](4)H[PW(11)Co(H(2)O)O(39)]-(PW(11)Co) is synthesized and used as a single-component, solvent-free catalyst in the cycloaddition reaction of CO(2) and epoxides to form cyclic carbonates.	Epoxy Compounds	226-234	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
22764083-1	2012	Co(II)-substituted alpha-Keggin-type 12-tungstenphosphate [(n-C(4)H(9))(4)N](4)H[PW(11)Co(H(2)O)O(39)]-(PW(11)Co) is synthesized and used as a single-component, solvent-free catalyst in the cycloaddition reaction of CO(2) and epoxides to form cyclic carbonates.	cyclic carbonates	243-260	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
22764083-3	2012	The reaction occurs through a single-electron transfer from the doublet Co(II) catalyst to the epoxide and forms a doublet Co(III)-carbon radical intermediate.	Epoxy Compounds	95-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-78
22764083-3	2012	The reaction occurs through a single-electron transfer from the doublet Co(II) catalyst to the epoxide and forms a doublet Co(III)-carbon radical intermediate.	co(iii)	123-130	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-78
22764083-3	2012	The reaction occurs through a single-electron transfer from the doublet Co(II) catalyst to the epoxide and forms a doublet Co(III)-carbon radical intermediate.	Carbon	131-137	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-78
22803970-1	2012	The synthesis and characterization of the complexes of Cu(I), Ag(I), Cu(II), and Co(II) ions with 1,2,5-selenadiazolopyridine (psd) is reported.	[1,2,5]Selenadiazolo[3,4-b]pyridine	98-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-86
22803970-1	2012	The synthesis and characterization of the complexes of Cu(I), Ag(I), Cu(II), and Co(II) ions with 1,2,5-selenadiazolopyridine (psd) is reported.	5'-O-[N-(PROLYL)-SULFAMOYL]ADENOSINE	127-130	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-86
22803970-7	2012	The crystal structures of Cu(I) and Ag(I) complexes revealed the dinuclear nature with characteristic metallophilic interactions [M   M] (M = Cu, Ag), while the Cu(II) and Co(II) complexes were mononuclear.	cuprous ion	26-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	172-178
22803970-7	2012	The crystal structures of Cu(I) and Ag(I) complexes revealed the dinuclear nature with characteristic metallophilic interactions [M   M] (M = Cu, Ag), while the Cu(II) and Co(II) complexes were mononuclear.	Copper	26-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	172-178
22830538-5	2012	The newly formed HS state is assigned to an acetate coordinated [Co(II)(1)]-(OAc(-)) complex, possessing an S = 3/2 spin ground state (species B, responsible for a broad EPR signal with g   4.6).	oac(-))	77-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-71
22830538-0	2012	Observation of an organic acid mediated spin state transition in a Co(II)-Schiff base complex: an EPR, HYSCORE, and DFT study.	organic acid	18-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-73
22830538-8	2012	This complex is tentatively assigned to a paramagnetic superoxo bridged dimer (AcO(-))[Co(II)(1)   O(2)(-)Co(III)(1)](HOAc), as distinct from the more common diamagnetic peroxo bridged dimers.	superoxo	55-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-93
22830538-8	2012	This complex is tentatively assigned to a paramagnetic superoxo bridged dimer (AcO(-))[Co(II)(1)   O(2)(-)Co(III)(1)](HOAc), as distinct from the more common diamagnetic peroxo bridged dimers.	co(iii)(1)	106-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-93
22830538-1	2012	The interactions of a weak organic acid (acetic acid, HOAc) with a toluene solution of the Co(II)-Schiff base type complex, (R,R")-N,N"-bis(3,5-di-tert-butylsalicylidene)-1,2-cyclohexane-diamino Co(II) (labeled [Co(1)]), was investigated using EPR, HYSCORE, and DFT computations.	organic acid	27-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-97
22830538-8	2012	This complex is tentatively assigned to a paramagnetic superoxo bridged dimer (AcO(-))[Co(II)(1)   O(2)(-)Co(III)(1)](HOAc), as distinct from the more common diamagnetic peroxo bridged dimers.	Acetic Acid	118-122	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-93
22830538-1	2012	The interactions of a weak organic acid (acetic acid, HOAc) with a toluene solution of the Co(II)-Schiff base type complex, (R,R")-N,N"-bis(3,5-di-tert-butylsalicylidene)-1,2-cyclohexane-diamino Co(II) (labeled [Co(1)]), was investigated using EPR, HYSCORE, and DFT computations.	organic acid	27-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	195-201
22830538-8	2012	This complex is tentatively assigned to a paramagnetic superoxo bridged dimer (AcO(-))[Co(II)(1)   O(2)(-)Co(III)(1)](HOAc), as distinct from the more common diamagnetic peroxo bridged dimers.	peroxo	57-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-93
22830538-1	2012	The interactions of a weak organic acid (acetic acid, HOAc) with a toluene solution of the Co(II)-Schiff base type complex, (R,R")-N,N"-bis(3,5-di-tert-butylsalicylidene)-1,2-cyclohexane-diamino Co(II) (labeled [Co(1)]), was investigated using EPR, HYSCORE, and DFT computations.	Acetic Acid	41-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-97
22830538-9	2012	Species C is characterized by a very broad HS EPR signal (g(x) = 5.1, g(y) = 3.9, g(z) = 2.1) and is reversibly formed by oxygenation of the LS [Co(II)(1)]-(HOAc) complex to the superoxo complex [Co(III)(1)O(2)(-)](HOAc), which subsequently forms the association complex C by interaction with the HS [Co(II)(1)](OAc(-)) species.	leucylserine	141-143	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-151
22830538-1	2012	The interactions of a weak organic acid (acetic acid, HOAc) with a toluene solution of the Co(II)-Schiff base type complex, (R,R")-N,N"-bis(3,5-di-tert-butylsalicylidene)-1,2-cyclohexane-diamino Co(II) (labeled [Co(1)]), was investigated using EPR, HYSCORE, and DFT computations.	Acetic Acid	54-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-97
22830538-9	2012	Species C is characterized by a very broad HS EPR signal (g(x) = 5.1, g(y) = 3.9, g(z) = 2.1) and is reversibly formed by oxygenation of the LS [Co(II)(1)]-(HOAc) complex to the superoxo complex [Co(III)(1)O(2)(-)](HOAc), which subsequently forms the association complex C by interaction with the HS [Co(II)(1)](OAc(-)) species.	leucylserine	141-143	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	301-307
22830538-9	2012	Species C is characterized by a very broad HS EPR signal (g(x) = 5.1, g(y) = 3.9, g(z) = 2.1) and is reversibly formed by oxygenation of the LS [Co(II)(1)]-(HOAc) complex to the superoxo complex [Co(III)(1)O(2)(-)](HOAc), which subsequently forms the association complex C by interaction with the HS [Co(II)(1)](OAc(-)) species.	Acetic Acid	157-161	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-151
22830538-9	2012	Species C is characterized by a very broad HS EPR signal (g(x) = 5.1, g(y) = 3.9, g(z) = 2.1) and is reversibly formed by oxygenation of the LS [Co(II)(1)]-(HOAc) complex to the superoxo complex [Co(III)(1)O(2)(-)](HOAc), which subsequently forms the association complex C by interaction with the HS [Co(II)(1)](OAc(-)) species.	superoxo	178-186	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-151
22830538-9	2012	Species C is characterized by a very broad HS EPR signal (g(x) = 5.1, g(y) = 3.9, g(z) = 2.1) and is reversibly formed by oxygenation of the LS [Co(II)(1)]-(HOAc) complex to the superoxo complex [Co(III)(1)O(2)(-)](HOAc), which subsequently forms the association complex C by interaction with the HS [Co(II)(1)](OAc(-)) species.	co(iii)(1)o(2)(-)	196-213	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-151
22830538-9	2012	Species C is characterized by a very broad HS EPR signal (g(x) = 5.1, g(y) = 3.9, g(z) = 2.1) and is reversibly formed by oxygenation of the LS [Co(II)(1)]-(HOAc) complex to the superoxo complex [Co(III)(1)O(2)(-)](HOAc), which subsequently forms the association complex C by interaction with the HS [Co(II)(1)](OAc(-)) species.	Acetic Acid	215-219	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-151
22830538-9	2012	Species C is characterized by a very broad HS EPR signal (g(x) = 5.1, g(y) = 3.9, g(z) = 2.1) and is reversibly formed by oxygenation of the LS [Co(II)(1)]-(HOAc) complex to the superoxo complex [Co(III)(1)O(2)(-)](HOAc), which subsequently forms the association complex C by interaction with the HS [Co(II)(1)](OAc(-)) species.	oac(	312-316	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-151
22830538-1	2012	The interactions of a weak organic acid (acetic acid, HOAc) with a toluene solution of the Co(II)-Schiff base type complex, (R,R")-N,N"-bis(3,5-di-tert-butylsalicylidene)-1,2-cyclohexane-diamino Co(II) (labeled [Co(1)]), was investigated using EPR, HYSCORE, and DFT computations.	Acetic Acid	54-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	195-201
22830538-12	2012	Overall, it appears that a facile interconversion of the [Co(1)] complex, possessing a LS ground state, occurs in the presence of acetic acid, producing both HS and LS Co(II) states, prior to formation of the oxidized active form of the catalyst, [Co(III)(1)](OAc(-)).	Acetic Acid	130-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	168-174
22830538-1	2012	The interactions of a weak organic acid (acetic acid, HOAc) with a toluene solution of the Co(II)-Schiff base type complex, (R,R")-N,N"-bis(3,5-di-tert-butylsalicylidene)-1,2-cyclohexane-diamino Co(II) (labeled [Co(1)]), was investigated using EPR, HYSCORE, and DFT computations.	Toluene	67-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-97
22830538-1	2012	The interactions of a weak organic acid (acetic acid, HOAc) with a toluene solution of the Co(II)-Schiff base type complex, (R,R")-N,N"-bis(3,5-di-tert-butylsalicylidene)-1,2-cyclohexane-diamino Co(II) (labeled [Co(1)]), was investigated using EPR, HYSCORE, and DFT computations.	Schiff Bases	98-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-97
22830538-2	2012	This activated [Co(II)(1)] system is extremely important within the context of asymmetric catalysts (notably the hydrolytic kinetic resolution of epoxides) despite the lack of detailed structural information about the nature of the paramagnetic species present.	Epoxy Compounds	146-154	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-22
22830538-3	2012	Under anaerobic conditions, the LS [Co(II)(1)] complex with a  yz, (2)A(2)) ground state is converted into a low-spin (LS) and a high-spin (HS) complex in the presence of the acid.	leucylserine	32-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-42
22830538-4	2012	The newly formed LS state is assigned to the coordinated [Co(II)(1)]-(HOAc) complex, possessing a  z(2), (2)A(1)) ground state (species A; g(x) = 2.42, g(y) = 2.28, g(z) = 2.02, A(x) = 100, A(y) = 120, A(z) = 310 MHz).	Acetic Acid	70-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-64
22830538-5	2012	The newly formed HS state is assigned to an acetate coordinated [Co(II)(1)]-(OAc(-)) complex, possessing an S = 3/2 spin ground state (species B, responsible for a broad EPR signal with g   4.6).	Acetates	44-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-71
22904774-1	2012	In the title polymeric complex, [Co(NCS)(2){SC(NH(2))(2)}(2)](n), the asymmetric unit comprises a Co(II) ion, which is situated on an inversion centre, an N-bound thio-cyanate anion and a mu(2)-bridging thio-urea mol-ecule.	Nitrogen	36-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-104
22904774-2	2012	The Co(II) atom is coordinated in a distorted octa-hedral fashion within an N(2)S(4) donor set.	n(2)s(4)	76-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
22904774-3	2012	The bridging thio-urea ligands link Co(II) ions into a polymeric chain extending along [100].	Thiourea	13-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-42
22542712-9	2012	In addition, CARD-024 partially stimulated members of the COX-2/IL-1beta inflammatory pathway.	1alpha-Hydroxyvitamin D5	13-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
22607196-0	2012	Oroxylin A improves the sensitivity of HT-29 human colon cancer cells to 5-FU through modulation of the COX-2 signaling pathway.	5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
22607196-0	2012	Oroxylin A improves the sensitivity of HT-29 human colon cancer cells to 5-FU through modulation of the COX-2 signaling pathway.	Fluorouracil	73-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
22607196-4	2012	A correlation between COX-2 inhibition by oroxylin A and a synergistic effect of 5-FU on the growth of HT-29 cells was observed, and a COX-2 pathway for this effect was recognized; oroxylin A evidently elevated the level of reactive oxygen species in HT-29 cells, which subsequently inhibited COX-2 expression and enhanced the susceptibility of HT-29 cells to 5-FU.	5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one	42-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-27
22607196-4	2012	A correlation between COX-2 inhibition by oroxylin A and a synergistic effect of 5-FU on the growth of HT-29 cells was observed, and a COX-2 pathway for this effect was recognized; oroxylin A evidently elevated the level of reactive oxygen species in HT-29 cells, which subsequently inhibited COX-2 expression and enhanced the susceptibility of HT-29 cells to 5-FU.	Fluorouracil	81-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-27
22607196-4	2012	A correlation between COX-2 inhibition by oroxylin A and a synergistic effect of 5-FU on the growth of HT-29 cells was observed, and a COX-2 pathway for this effect was recognized; oroxylin A evidently elevated the level of reactive oxygen species in HT-29 cells, which subsequently inhibited COX-2 expression and enhanced the susceptibility of HT-29 cells to 5-FU.	5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one	181-191	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-27
22607196-4	2012	A correlation between COX-2 inhibition by oroxylin A and a synergistic effect of 5-FU on the growth of HT-29 cells was observed, and a COX-2 pathway for this effect was recognized; oroxylin A evidently elevated the level of reactive oxygen species in HT-29 cells, which subsequently inhibited COX-2 expression and enhanced the susceptibility of HT-29 cells to 5-FU.	5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one	181-191	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-140
22607196-4	2012	A correlation between COX-2 inhibition by oroxylin A and a synergistic effect of 5-FU on the growth of HT-29 cells was observed, and a COX-2 pathway for this effect was recognized; oroxylin A evidently elevated the level of reactive oxygen species in HT-29 cells, which subsequently inhibited COX-2 expression and enhanced the susceptibility of HT-29 cells to 5-FU.	5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one	181-191	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-140
22607196-4	2012	A correlation between COX-2 inhibition by oroxylin A and a synergistic effect of 5-FU on the growth of HT-29 cells was observed, and a COX-2 pathway for this effect was recognized; oroxylin A evidently elevated the level of reactive oxygen species in HT-29 cells, which subsequently inhibited COX-2 expression and enhanced the susceptibility of HT-29 cells to 5-FU.	Reactive Oxygen Species	224-247	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-27
22607196-4	2012	A correlation between COX-2 inhibition by oroxylin A and a synergistic effect of 5-FU on the growth of HT-29 cells was observed, and a COX-2 pathway for this effect was recognized; oroxylin A evidently elevated the level of reactive oxygen species in HT-29 cells, which subsequently inhibited COX-2 expression and enhanced the susceptibility of HT-29 cells to 5-FU.	Reactive Oxygen Species	224-247	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-140
22607196-4	2012	A correlation between COX-2 inhibition by oroxylin A and a synergistic effect of 5-FU on the growth of HT-29 cells was observed, and a COX-2 pathway for this effect was recognized; oroxylin A evidently elevated the level of reactive oxygen species in HT-29 cells, which subsequently inhibited COX-2 expression and enhanced the susceptibility of HT-29 cells to 5-FU.	Reactive Oxygen Species	224-247	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-140
22607196-4	2012	A correlation between COX-2 inhibition by oroxylin A and a synergistic effect of 5-FU on the growth of HT-29 cells was observed, and a COX-2 pathway for this effect was recognized; oroxylin A evidently elevated the level of reactive oxygen species in HT-29 cells, which subsequently inhibited COX-2 expression and enhanced the susceptibility of HT-29 cells to 5-FU.	Fluorouracil	360-364	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-27
22607196-4	2012	A correlation between COX-2 inhibition by oroxylin A and a synergistic effect of 5-FU on the growth of HT-29 cells was observed, and a COX-2 pathway for this effect was recognized; oroxylin A evidently elevated the level of reactive oxygen species in HT-29 cells, which subsequently inhibited COX-2 expression and enhanced the susceptibility of HT-29 cells to 5-FU.	Fluorouracil	360-364	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-140
22607196-4	2012	A correlation between COX-2 inhibition by oroxylin A and a synergistic effect of 5-FU on the growth of HT-29 cells was observed, and a COX-2 pathway for this effect was recognized; oroxylin A evidently elevated the level of reactive oxygen species in HT-29 cells, which subsequently inhibited COX-2 expression and enhanced the susceptibility of HT-29 cells to 5-FU.	Fluorouracil	360-364	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-140
22607196-5	2012	Likely also related to COX-2 inhibition, oroxylin A decreased PGE(2) levels in HT-29 cells.	5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one	41-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-28
22607196-9	2012	This synergistic effect may be mainly related to COX-2 inhibition by oroxylin A in HT-29 cells.	5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one	69-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-54
22805469-13	2012	CONCLUSIONS AND CLINICAL RELEVANCE: These results suggest that the regulatory effects of LPS on eosinophilic airway inflammation are controlled via the COX-2/PGE(2)  axis.	Prostaglandins E	158-161	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-157
22170686-0	2012	The role of COX-2/PGE2 in gossypol-induced apoptosis of colorectal carcinoma cells.	Gossypol	26-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-17
22592909-0	2012	Quercetin inhibits IL-1beta-induced proliferation and production of MMPs, COX-2, and PGE2 by rheumatoid synovial fibroblast.	Quercetin	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
22592909-4	2012	Quercetin inhibits unstimulated and IL-1beta-induced proliferation of RASFs and MMP-1, 3, COX-2 messenger ribonucleic acid and protein expression, PGE2 production induced with IL-1beta.	Quercetin	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-95
22592909-6	2012	These results indicate that quercetin inhibits synovial fibroblasts proliferation and MMPs, COX-2, and PGE2 production, which involved joint destruction in rheumatoid arthritis (RA), and suggest that it might be a new therapeutic agent for management of RA.	Quercetin	28-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-97
22609261-7	2012	The up-regulation of COX-2 mRNA and increased COX-2 protein expression induced by CSS were also inhibited by more than 3.7-fold with ciglitazone pre-treatment.	thiocysteine	82-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-26
22609261-7	2012	The up-regulation of COX-2 mRNA and increased COX-2 protein expression induced by CSS were also inhibited by more than 3.7-fold with ciglitazone pre-treatment.	thiocysteine	82-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
22609261-7	2012	The up-regulation of COX-2 mRNA and increased COX-2 protein expression induced by CSS were also inhibited by more than 3.7-fold with ciglitazone pre-treatment.	ciglitazone	133-144	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-26
22609261-7	2012	The up-regulation of COX-2 mRNA and increased COX-2 protein expression induced by CSS were also inhibited by more than 3.7-fold with ciglitazone pre-treatment.	ciglitazone	133-144	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
22689323-1	2012	The Co(II) complexes of twelve meso-tetraaryl-porphyrins, -chlorins, and chlorin analogues containing non-pyrrolic heterocycles were synthesized and converted in situ to the corresponding Co(III) complexes coordinated to one or two imidazoles.	meso-tetraaryl-porphyrins	31-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
22689323-1	2012	The Co(II) complexes of twelve meso-tetraaryl-porphyrins, -chlorins, and chlorin analogues containing non-pyrrolic heterocycles were synthesized and converted in situ to the corresponding Co(III) complexes coordinated to one or two imidazoles.	chlorin	59-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
22689323-1	2012	The Co(II) complexes of twelve meso-tetraaryl-porphyrins, -chlorins, and chlorin analogues containing non-pyrrolic heterocycles were synthesized and converted in situ to the corresponding Co(III) complexes coordinated to one or two imidazoles.	chlorin	59-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
22689323-1	2012	The Co(II) complexes of twelve meso-tetraaryl-porphyrins, -chlorins, and chlorin analogues containing non-pyrrolic heterocycles were synthesized and converted in situ to the corresponding Co(III) complexes coordinated to one or two imidazoles.	Imidazoles	232-242	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
22170686-2	2012	In the present study, 12-O-tetradecanoylphorbol-13-acetate (TPA) addition significantly inhibited GOS-induced apoptosis in human colorectal carcinoma HT-29 cells in accordance with inducing COX-2 protein/PGE(2) production.	Tetradecanoylphorbol Acetate	22-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	190-195
22170686-2	2012	In the present study, 12-O-tetradecanoylphorbol-13-acetate (TPA) addition significantly inhibited GOS-induced apoptosis in human colorectal carcinoma HT-29 cells in accordance with inducing COX-2 protein/PGE(2) production.	Tetradecanoylphorbol Acetate	60-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	190-195
22170686-2	2012	In the present study, 12-O-tetradecanoylphorbol-13-acetate (TPA) addition significantly inhibited GOS-induced apoptosis in human colorectal carcinoma HT-29 cells in accordance with inducing COX-2 protein/PGE(2) production.	Gossypol	98-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	190-195
22170686-3	2012	TPA inhibition of GOS-induced apoptosis was blocked by adding protein kinase (PK)C inhibitors including staurosporine (ST), GF109203X (GF), and H7, characterized by the occurrence of cleaved caspase 3 proteins and a decrease in COX-2 protein/PGE(2) production in HT-29 cells.	Tetradecanoylphorbol Acetate	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	228-233
22170686-8	2012	COLO205-T cells were established through sustained TPA incubation of COLO205 cells, and COLO205-T cells showed a lower sensitivity to GOS-induced cell death with increased COX-2 (not Bcl-2 and Mcl-1) protein than parental COLO-205 cells.	Gossypol	134-137	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	172-177
22170686-3	2012	TPA inhibition of GOS-induced apoptosis was blocked by adding protein kinase (PK)C inhibitors including staurosporine (ST), GF109203X (GF), and H7, characterized by the occurrence of cleaved caspase 3 proteins and a decrease in COX-2 protein/PGE(2) production in HT-29 cells.	Gossypol	18-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	228-233
22170686-9	2012	A decrease in COX-2 protein expression in COLO205-T cells by COX-2 siRNA transfection or enhanced GOS-induced cell death according to MTT assay and DNA integrity assay.	Gossypol	98-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
22170686-9	2012	A decrease in COX-2 protein expression in COLO205-T cells by COX-2 siRNA transfection or enhanced GOS-induced cell death according to MTT assay and DNA integrity assay.	monooxyethylene trimethylolpropane tristearate	134-137	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
22170686-10	2012	The notion of COX-2/PGE(2) activation against GOS-induced apoptosis in colon carcinoma cells was demonstrated, and the combination of GOS and COX-2 inhibitors to treat colon carcinoma possesses clinical potential worthy of further investigation.	Gossypol	46-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
22170686-7	2012	Furthermore, GOS had an effective apoptotic effect on COLO205 colorectal carcinoma cells which expressed undetectable level of endogenous COX-2 protein than HT-29 cells, and the decreased COX-2 protein level via COX-2 siRNA or addition of COX-2 activity inhibitor NS significantly elevated GOS-induced cell death in HT-29 cells.	Gossypol	13-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	138-143
22170686-7	2012	Furthermore, GOS had an effective apoptotic effect on COLO205 colorectal carcinoma cells which expressed undetectable level of endogenous COX-2 protein than HT-29 cells, and the decreased COX-2 protein level via COX-2 siRNA or addition of COX-2 activity inhibitor NS significantly elevated GOS-induced cell death in HT-29 cells.	Gossypol	13-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	188-193
22170686-7	2012	Furthermore, GOS had an effective apoptotic effect on COLO205 colorectal carcinoma cells which expressed undetectable level of endogenous COX-2 protein than HT-29 cells, and the decreased COX-2 protein level via COX-2 siRNA or addition of COX-2 activity inhibitor NS significantly elevated GOS-induced cell death in HT-29 cells.	Gossypol	13-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	188-193
22170686-7	2012	Furthermore, GOS had an effective apoptotic effect on COLO205 colorectal carcinoma cells which expressed undetectable level of endogenous COX-2 protein than HT-29 cells, and the decreased COX-2 protein level via COX-2 siRNA or addition of COX-2 activity inhibitor NS significantly elevated GOS-induced cell death in HT-29 cells.	Gossypol	13-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	188-193
22335196-5	2012	Melatonin significantly inhibited COX-2 expression and prostaglandin E(2) (PGE2) production, abrogated p300 histone acetyltransferase activity and p300-mediated NF-kappaB acetylation, thereby blocking NF-kappaB binding and p300 recruitment to COX-2 promoter.	Melatonin	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-39
22335196-5	2012	Melatonin significantly inhibited COX-2 expression and prostaglandin E(2) (PGE2) production, abrogated p300 histone acetyltransferase activity and p300-mediated NF-kappaB acetylation, thereby blocking NF-kappaB binding and p300 recruitment to COX-2 promoter.	Melatonin	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	243-248
22335196-0	2012	Simultaneous modulation of COX-2, p300, Akt, and Apaf-1 signaling by melatonin to inhibit proliferation and induce apoptosis in breast cancer cells.	Melatonin	69-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-32
22335196-6	2012	Pretreatment with a COX-2- or p300-selective inhibitor abrogated the melatonin-induced inhibition of cell proliferation, whereas PGE2 treatment or COX-2 transfection reversed the inhibition by melatonin.	Melatonin	69-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-25
22335196-4	2012	The observed suppression of proliferation was accompanied by the melatonin-mediated inhibition of COX-2, p300, and NF-kappaB signaling.	Melatonin	65-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-103
22335196-6	2012	Pretreatment with a COX-2- or p300-selective inhibitor abrogated the melatonin-induced inhibition of cell proliferation, whereas PGE2 treatment or COX-2 transfection reversed the inhibition by melatonin.	Melatonin	193-202	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-152
22335196-12	2012	These results therefore indicate that melatonin inhibits cell proliferation and induces apoptosis in MDA-MB-361 breast cancer cells in vitro by simultaneously suppressing the COX-2/PGE2, p300/NF-kappaB, and PI3K/Akt/signaling and activating the Apaf-1/caspase-dependent apoptotic pathway.	Melatonin	38-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	175-180
22641101-1	2012	We reported that cyclo-oxygenase (COX)-2 expression in human breast cancer stimulated cancer cell migration and invasiveness, production of vascular endothelial growth factor (VEGF)-C and lymphangiogenesis in situ, largely from endogenous PGE2-mediated stimulation of prostaglandin E (EP)1 and EP4 receptors, presenting them as candidate therapeutic targets against lymphatic metastasis.	Dinoprostone	239-243	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-40
22934275-2	2012	PGE(2) initiates an EP2/EP4-mediated positive feedback between COX2 and PGE(2) in monocytic precursors, redirecting dendritic cell differentiation to MDSCs.	Prostaglandins E	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-67
23097685-3	2012	Similarly, key enzymes that control the production of prostaglandins, cyclooxygenases (COX-1 and COX-2, prototypic targets of Non-steroidal anti-inflammatory drugs (NSAIDs)), are frequently over-expressed or de-regulated in the progression of cancer.	Prostaglandins	54-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
23135108-2	2012	METHODS: RT-PCR and Western blotting were used to detect the effect of NS-398, the COX-2 inhibitor on mRNA and protein expression of VEGF and Survivin in oral squamous carcinoma cell line Tca8113.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	71-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
22101002-6	2012	Additional studies showed that TNF produced by mTAL cells inhibits 86Rb uptake, an in vitro correlate of natriuresis, in an autocrine- and COX-2-dependent manner.	Rubidium-86	67-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-144
22119250-3	2012	COX-2 expression is regulated by the renin-angiotensin system, glucocorticoids or mineralcorticoids, and aldosterone, supporting a role for COX-2 in kidney function.	Aldosterone	105-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
22119250-4	2012	Indeed, COX-2 mRNA and protein levels as well as enzyme activity are increased, along with PGE2, during kidney failure.	Dinoprostone	91-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	8-13
22119250-5	2012	In addition, changes in COX-2 expression are associated with increased blood pressure, urinary volume, sodium and protein and decreased urinary osmolarity.	Sodium	103-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
22119250-6	2012	Intrarenal mechanisms such as angiotensin II (Ang II) production, increased sodium delivery, glomerular hypertension, and renal tubular inflammation have been suggested to be responsible for the increase in COX-2 expression.	Sodium	76-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	207-212
22731779-3	2012	Single-crystal X-ray structural determination of 2 shows a 4 + 1 coordination around the cobalt(II) center with a rather long bond between Co(II) and the central amine nitrogen atom of tbta.	Cobalt(2+)	89-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-145
22491744-1	2012	The redox-active fac-[Mo(V)(mp)(3)](-) (mp: o-mercaptophenolato) bearing asymmetric O- and S-cation binding sites can bind with several kinds of metal ions such as Na(+), Mn(II), Fe(II), Co(II), Ni(II), and Cu(I).	Metals	145-150	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	187-193
22491744-1	2012	The redox-active fac-[Mo(V)(mp)(3)](-) (mp: o-mercaptophenolato) bearing asymmetric O- and S-cation binding sites can bind with several kinds of metal ions such as Na(+), Mn(II), Fe(II), Co(II), Ni(II), and Cu(I).	Manganese(2+)	171-177	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	187-193
22491744-1	2012	The redox-active fac-[Mo(V)(mp)(3)](-) (mp: o-mercaptophenolato) bearing asymmetric O- and S-cation binding sites can bind with several kinds of metal ions such as Na(+), Mn(II), Fe(II), Co(II), Ni(II), and Cu(I).	ammonium ferrous sulfate	179-185	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	187-193
22491744-1	2012	The redox-active fac-[Mo(V)(mp)(3)](-) (mp: o-mercaptophenolato) bearing asymmetric O- and S-cation binding sites can bind with several kinds of metal ions such as Na(+), Mn(II), Fe(II), Co(II), Ni(II), and Cu(I).	Nickel(2+)	195-201	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	187-193
22491744-1	2012	The redox-active fac-[Mo(V)(mp)(3)](-) (mp: o-mercaptophenolato) bearing asymmetric O- and S-cation binding sites can bind with several kinds of metal ions such as Na(+), Mn(II), Fe(II), Co(II), Ni(II), and Cu(I).	cuprous ion	207-212	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	187-193
22731779-3	2012	Single-crystal X-ray structural determination of 2 shows a 4 + 1 coordination around the cobalt(II) center with a rather long bond between Co(II) and the central amine nitrogen atom of tbta.	titanocene bis(trichloroacetate)	185-189	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-145
22731779-5	2012	1 and 2 are thus the first examples of pseudotetrahedral coordinated Fe(II) and Co(II) complexes with tbta.	titanocene bis(trichloroacetate)	102-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-86
22639389-5	2012	The fluorescence properties of the isostructural capsules were strongly dependent on the identity of the metal species: the Zn(II) capsule emitted strong blue fluorescence with a high quantum yield (Phi=0.8), in sharp contrast to the weakly emissive Ni(II) and Mn(II) capsules and the completely non-emissive Pd(II), Pt(II), and Co(II) capsules.	Metals	105-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	329-335
22639389-5	2012	The fluorescence properties of the isostructural capsules were strongly dependent on the identity of the metal species: the Zn(II) capsule emitted strong blue fluorescence with a high quantum yield (Phi=0.8), in sharp contrast to the weakly emissive Ni(II) and Mn(II) capsules and the completely non-emissive Pd(II), Pt(II), and Co(II) capsules.	Zinc	124-130	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	329-335
22807751-4	2012	The title structure gives the first example of the [Co(C2O4)3]4- anion, with the distorted octa-hedral environment of Co(II) center formed by six O atoms from three oxalate residues.	co(c2o4)	52-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-124
22807751-4	2012	The title structure gives the first example of the [Co(C2O4)3]4- anion, with the distorted octa-hedral environment of Co(II) center formed by six O atoms from three oxalate residues.	Oxalates	165-172	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-124
22517768-4	2012	Treatment of Caco-2 colon cancer cells with the PAR(2)-activating peptide 2-furoyl-LIGRLO-NH(2) (2fLI), but not by its reverse-sequence PAR(2)-inactive peptide, for 3 h led to an increase in intracellular COX-2 protein expression accompanied by a COX-2-dependent increase in prostaglandin E(2) production.	2-furoyl	74-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	205-210
22517768-4	2012	Treatment of Caco-2 colon cancer cells with the PAR(2)-activating peptide 2-furoyl-LIGRLO-NH(2) (2fLI), but not by its reverse-sequence PAR(2)-inactive peptide, for 3 h led to an increase in intracellular COX-2 protein expression accompanied by a COX-2-dependent increase in prostaglandin E(2) production.	2-furoyl	74-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	247-252
22517768-7	2012	The broad-spectrum metalloproteinase inhibitor marimastat inhibited both COX-2 expression and EGFR phosphorylation.	marimastat	47-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-78
22517768-8	2012	The EGFR tyrosine kinase inhibitor PD153035 also abolished 2fLI-induced COX-2 expression.	4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline	35-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
22517768-10	2012	However, inhibition of either Src tyrosine kinase signaling by PP2, Rho kinase signaling by Y27632, or phosphatidylinositol 3 (PI3) kinase signaling by LY294002 prevented 2fLI-induced COX-2 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	152-160	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	184-189
22578527-0	2012	myo-Inositol esters of indomethacin as COX-2 inhibitors.	myo-inositol esters	0-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-44
22578527-0	2012	myo-Inositol esters of indomethacin as COX-2 inhibitors.	Indomethacin	23-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-44
22578527-7	2012	Indomethacin ester (2) was completely stable at pH 4.0-8.5 over 24h at 37 C and showed comparable activity to indomethacin in a COX-2 assay (pH 8.0).	indomethacin ester	0-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	128-133
22450432-2	2012	The complexes are essentially isostructural and isomorphous, allowing the Co(II) and Cu(II) complexes to co-crystallize in mixed-metal solid solutions with the formula [Co(x)Cu(1-x)(DDOP)(NO(3))(H(2)O)](NO(3)), where x = 0.4 (4), 0.1 (5), and 0.7 (6).	Metals	129-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-80
22626465-9	2012	This may be associated with the significant suppression of PGE(2) /IL-8 secretion via the down-regulated expression of COX-2 and IL-8 at the gene and/or protein levels.	Prostaglandins E	59-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-124
22159752-7	2012	RESULTS: The co-treatment with celecoxib enhanced NPC-16-induced apoptosis in HCT116 (COX-2 no expression), HT29 (COX-2 higher expression) and Caco-2 (COX-2 higher expression) colorectal cancer cells, which was mediated by the elevated NPC-16 uptake via the effect of celecoxib on polyamine metabolism, including the up-regulated spermidine/spermine N(1)-acetyltransferase (SSAT) activity and reduced intracellular polyamine levels.	Celecoxib	31-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-91
22159752-7	2012	RESULTS: The co-treatment with celecoxib enhanced NPC-16-induced apoptosis in HCT116 (COX-2 no expression), HT29 (COX-2 higher expression) and Caco-2 (COX-2 higher expression) colorectal cancer cells, which was mediated by the elevated NPC-16 uptake via the effect of celecoxib on polyamine metabolism, including the up-regulated spermidine/spermine N(1)-acetyltransferase (SSAT) activity and reduced intracellular polyamine levels.	Celecoxib	31-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-119
22159752-7	2012	RESULTS: The co-treatment with celecoxib enhanced NPC-16-induced apoptosis in HCT116 (COX-2 no expression), HT29 (COX-2 higher expression) and Caco-2 (COX-2 higher expression) colorectal cancer cells, which was mediated by the elevated NPC-16 uptake via the effect of celecoxib on polyamine metabolism, including the up-regulated spermidine/spermine N(1)-acetyltransferase (SSAT) activity and reduced intracellular polyamine levels.	Celecoxib	31-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-119
22159752-11	2012	CONCLUSIONS: Co-treatment of celecoxib and NPC-16 could induce colorectal cancer cell apoptosis via COX-2-independent and caspase-dependent mechanisms.	Celecoxib	29-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-105
23174742-0	2012	Three concerns with regards to the utilization of COX-2 inhibitor (celecoxib) in combination with standard chemoradiotherapy for nasopharyngeal carcinoma.	Celecoxib	67-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-55
22632102-0	2012	Colon-specific delivery of celecoxib is a potential strategy to improve toxicological and pharmacological properties of the selective Cox-2 inhibitor: implication in treatment of familiar adenomatous polyposis.	Celecoxib	27-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-139
22632102-2	2012	N-succinylglutam-1 or 5-yl celecoxib (SG1C and SG5C) were prepared as a colon-specific prodrug of celecoxib, a selective Cox-2 inhibitor, and investigated whether the celecoxib derivatives could deliver celecoxib to the target site and improve cardiovascular toxicity and therapeutic effectiveness for the treatment of familiar adenomatous polyposis.	Celecoxib	27-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-126
26105266-18	2012	PTGS2 (+3%;p=0.03) is part of the COX 2 prostaglandin pathway involved in inflammation.	Prostaglandins	40-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-39
22130459-1	2012	Parecoxib is an inactive pro-drug that is rapidly converted to valdecoxib, a selective cyclooxygenase (COX)-2 inhibitor registered for the management of post-operative pain in humans.	parecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-109
22130459-1	2012	Parecoxib is an inactive pro-drug that is rapidly converted to valdecoxib, a selective cyclooxygenase (COX)-2 inhibitor registered for the management of post-operative pain in humans.	valdecoxib	63-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-109
22931576-1	2012	OBJECTIVE: To investigate the effect of alloy leaching liquor of four different types of base metal alloy on the expression of prostaglandin E(2) (PGE(2)) and cyclo-oxygenase-2(COX-2) by human gingival fibroblast(HGF) in vitro.	Dinoprostone	127-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	177-182
22931576-7	2012	Immunofluorescence showed dark and uniform COX-2 stain in Ni-Cr and Co-Cr alloy groups, while in pure Ti group, Au alloy group, and negative control group shallow and uneven distribution of COX-2 stain were observed.	ni-cr	58-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
22931576-7	2012	Immunofluorescence showed dark and uniform COX-2 stain in Ni-Cr and Co-Cr alloy groups, while in pure Ti group, Au alloy group, and negative control group shallow and uneven distribution of COX-2 stain were observed.	Cobalt	68-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
22931576-7	2012	Immunofluorescence showed dark and uniform COX-2 stain in Ni-Cr and Co-Cr alloy groups, while in pure Ti group, Au alloy group, and negative control group shallow and uneven distribution of COX-2 stain were observed.	Chromium	61-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
22584488-2	2012	These two complexes were obtained upon reaction of dpm-py with the (acacpy(2))M homoleptic species (M = Cu(II), Co(II)).	dpm-py	51-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-119
22735784-1	2012	Self-assembled molecular films of two cobalt porphyrins with amine groups at different positions-(5,10,15,20-tetrakis-(2-aminophenyl) porphyrin-cobalt(II), [Co(II) (T(o-NH(2))PP)] and (5,10,15,20-tetrakis-(4-aminophenyl) porphyrin-cobalt(II), [Co(II)(T(p-NH(2))PP)]-were formed on a gold substrate.	cobalt porphyrins	38-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	157-163
22944132-2	2012	METHODS: The siRNA vector was established for cox-2 gene and then induced into esophageal cancer cell EC9706 by lipofectamine.	Lipofectamine	112-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
22483553-3	2012	Several pathways and specific targets including NF-kappaB, STAT3, COX-2, Akt and multidrug resistant protein have been identified to facilitate curcumin as a chemosensitizer.	Curcumin	144-152	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-71
22576963-2	2012	From the direct reaction of the ligand (H(3)L) with Co(II), Ni(II) and Cu(II) chlorides, and Fe(III)and Zn(II)nitrates in 2 M/1 L molar ratio, the five new neutral complexes were prepared.	h(3)l)	40-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-58
22481026-11	2012	In Calu-3 cells, 15d-PGJ(2) production resulted from COX-2-regulated COX-1 activation, while CFTR(inh172)-induced alteration of 15d-PGJ(2) synthesis involved both decreased expression of PGD synthase and disturbed relationships between both COXs.	15d-pgj	17-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-58
22344367-5	2012	In this study, we investigated the in vitro and in vivo effect of TMP in tumorigenesis and whether COX-2 is a molecular target of TMP.	tetramethylpyrazine	130-133	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-104
22344367-7	2012	In vitro treatment of A549 cells with TMP resulted in a significant inhibition of invasion, associated with reduced activities of COX-2 and MMP-2/TIMP-2.	tetramethylpyrazine	38-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	130-135
22344367-9	2012	This preclinical study provides the first evidence for the novel anti-tumor effects of TMP as a COX-2 pathway inhibitor in human adenocarcinoma cell line A549.	tetramethylpyrazine	87-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-101
22142375-1	2012	BACKGROUND AND AIM: Significant elevations in liver transaminases were noted in some patients during pre-marketing clinical trials with lumiracoxib, a selective COX-2 inhibitor.	lumiracoxib	136-147	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	161-166
21944479-0	2012	Protective role of cyclooxygenase (COX)-2 in experimental lung injury: evidence of a lipoxin A4-mediated effect.	lipoxin A4	85-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-41
21944479-3	2012	Pulmonary cyclooxygenase (COX)-2 protects against acid aspiration and bacterial instillation via lipoxins, a family of potent anti-inflammatory lipid mediators.	Lipoxins	97-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-32
22332123-10	2012	At a concentration as low as 5 muM, SFN completely inhibited mPGES, COX-2 and iNOS at the mRNA and protein levels, and proteoglycan and type II collagen degradation product release in explant culture.	sulforaphane	36-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-73
22934397-7	2012	Patients of the control group were treated by oral administration of Celebrex (a specific inhibitor of COX-2, 200 mg/time, once daily, 4 weeks together).	Celecoxib	69-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-108
22643354-0	2012	Synthesis, spectroscopy, thermal analysis, magnetic properties and biological activity studies of Cu(II) and Co(II) complexes with Schiff base dye ligands.	Schiff Bases	131-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-115
22634839-2	2012	Evidence shows that cantharidin induces human bladder carcinoma cell death through COX-2 overexpression in vitro.	Cantharidin	20-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
22536852-14	2012	Notably, the observed k(2) values (M(-1) s(-1)) for Mn(II) (2a, 0.152), Co(II) (3a, 0.208), and Zn(II) (4a, 0.230) complexes (1a, 0.058; already reported) linearly correlate with Z(eff)/r values of the metal ion.	Metals	202-207	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-78
22505053-1	2012	Trapped in a noble cube: A novel family of noble metalates has been discovered in which a 3d metal ion M (M = Mn(II), Fe(III), Co(II), Cu(II), Zn(II)) is encapsulated by a 12 palladium-oxo cage {Pd(12)O(32)}, which is capped by eight phosphate groups.	metalates	49-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	127-133
22505053-1	2012	Trapped in a noble cube: A novel family of noble metalates has been discovered in which a 3d metal ion M (M = Mn(II), Fe(III), Co(II), Cu(II), Zn(II)) is encapsulated by a 12 palladium-oxo cage {Pd(12)O(32)}, which is capped by eight phosphate groups.	Metals	49-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	127-133
22505053-1	2012	Trapped in a noble cube: A novel family of noble metalates has been discovered in which a 3d metal ion M (M = Mn(II), Fe(III), Co(II), Cu(II), Zn(II)) is encapsulated by a 12 palladium-oxo cage {Pd(12)O(32)}, which is capped by eight phosphate groups.	Manganese(2+)	110-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	127-133
22505053-1	2012	Trapped in a noble cube: A novel family of noble metalates has been discovered in which a 3d metal ion M (M = Mn(II), Fe(III), Co(II), Cu(II), Zn(II)) is encapsulated by a 12 palladium-oxo cage {Pd(12)O(32)}, which is capped by eight phosphate groups.	Zinc	143-149	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	127-133
22505053-1	2012	Trapped in a noble cube: A novel family of noble metalates has been discovered in which a 3d metal ion M (M = Mn(II), Fe(III), Co(II), Cu(II), Zn(II)) is encapsulated by a 12 palladium-oxo cage {Pd(12)O(32)}, which is capped by eight phosphate groups.	Palladium	175-184	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	127-133
22505053-1	2012	Trapped in a noble cube: A novel family of noble metalates has been discovered in which a 3d metal ion M (M = Mn(II), Fe(III), Co(II), Cu(II), Zn(II)) is encapsulated by a 12 palladium-oxo cage {Pd(12)O(32)}, which is capped by eight phosphate groups.	oxo	185-188	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	127-133
22505053-1	2012	Trapped in a noble cube: A novel family of noble metalates has been discovered in which a 3d metal ion M (M = Mn(II), Fe(III), Co(II), Cu(II), Zn(II)) is encapsulated by a 12 palladium-oxo cage {Pd(12)O(32)}, which is capped by eight phosphate groups.	pd(12)o	195-202	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	127-133
22505053-1	2012	Trapped in a noble cube: A novel family of noble metalates has been discovered in which a 3d metal ion M (M = Mn(II), Fe(III), Co(II), Cu(II), Zn(II)) is encapsulated by a 12 palladium-oxo cage {Pd(12)O(32)}, which is capped by eight phosphate groups.	Phosphates	234-243	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	127-133
22411404-0	2012	Two isomorphous Mn(II) and Co(II) 5-amino-tetrazolate coordination polymers with magnetic Delta-chains: crystal structures and magnetic properties.	Polymers	67-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-33
22411404-3	2012	Magnetic investigations indicate that Co(II) compound exhibits not only spin canting but also metamagnetic behaviors, while only spin-canted antiferromagnetic behaviors was observed in Mn(II) compound.	Manganese(2+)	185-191	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-44
21940785-2	2012	Some clinicians think that HFS is a type of inflammation limited to the hands and feet and can be prevented with a COX-2 inhibitor (celecoxib).	Celecoxib	132-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-120
22370236-9	2012	RESULTS: CAPE significantly inhibited H(2)O(2)-induced upregulation of TNF-alpha and COX-2 expression in a dose and time dependent manner.	caffeic acid phenethyl ester	9-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-90
22370236-9	2012	RESULTS: CAPE significantly inhibited H(2)O(2)-induced upregulation of TNF-alpha and COX-2 expression in a dose and time dependent manner.	Hydrogen Peroxide	38-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-90
22370236-13	2012	CONCLUSIONS: These findings suggest that inflammation induced by H(2)O(2) can be inhibited by CAPE via inhibition of the expression of pro-inflammatory cytokines such as TNF-alpha and COX-2.	Hydrogen Peroxide	65-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	184-189
22370236-13	2012	CONCLUSIONS: These findings suggest that inflammation induced by H(2)O(2) can be inhibited by CAPE via inhibition of the expression of pro-inflammatory cytokines such as TNF-alpha and COX-2.	caffeic acid phenethyl ester	94-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	184-189
22395577-1	2012	The Cu(II) ions usually have different coordinated geometry to other 3d ions, especially Ni(II) and Co(II) ions, in azido-carboxylate mixed ligand systems.	cu(ii)	4-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-106
22395577-1	2012	The Cu(II) ions usually have different coordinated geometry to other 3d ions, especially Ni(II) and Co(II) ions, in azido-carboxylate mixed ligand systems.	azido-carboxylate	116-133	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-106
22395577-3	2012	Assembling Cu(II), M(II) (M = Ni and Co), azido and nicotinic acid in hydrothermal condition, two novel isomorphic 3D heterometallic 3d-3d azido complexes, [CuM(N(3))(2)(nicotinate)(2)]( ) (M = Ni(II) for 1 and Co(II) for 2) were obtained.	Cobalt	37-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	211-217
22395577-3	2012	Assembling Cu(II), M(II) (M = Ni and Co), azido and nicotinic acid in hydrothermal condition, two novel isomorphic 3D heterometallic 3d-3d azido complexes, [CuM(N(3))(2)(nicotinate)(2)]( ) (M = Ni(II) for 1 and Co(II) for 2) were obtained.	3',5-diazido-2',3'-dideoxyuridine	139-144	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	211-217
22159752-0	2012	COX-2-independent induction of apoptosis by celecoxib and polyamine naphthalimide conjugate mediated by polyamine depression in colorectal cancer cell lines.	Celecoxib	44-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
22159752-0	2012	COX-2-independent induction of apoptosis by celecoxib and polyamine naphthalimide conjugate mediated by polyamine depression in colorectal cancer cell lines.	polyamine naphthalimide	58-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
22159752-0	2012	COX-2-independent induction of apoptosis by celecoxib and polyamine naphthalimide conjugate mediated by polyamine depression in colorectal cancer cell lines.	Polyamines	58-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
22546756-7	2012	With wortmannin, a specific PI3K inhibitor can simulate the effect of COX-2 inhibitors.	Wortmannin	5-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-75
22415852-3	2012	In the present study, we explored novel effects of celecoxib (CXB), a COX-2 specific inhibitor, on primary cultures of human ADPKD cyst-lining epithelial cells.	Celecoxib	51-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-75
22713947-0	2012	Molecular docking studies of withanolides against Cox-2 enzyme.	Withanolides	29-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-55
22713947-4	2012	In the present study we focus the extensive use of tool and graphical software for the identification of the binding energy of selected Withanolides like Withaferin -A, Withanolide-D from Withaniasomnifera and to screen the phytoconstituents that will dock/bind to the active sites of COX-2 enzyme.	Withanolides	136-148	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	285-290
22713947-4	2012	In the present study we focus the extensive use of tool and graphical software for the identification of the binding energy of selected Withanolides like Withaferin -A, Withanolide-D from Withaniasomnifera and to screen the phytoconstituents that will dock/bind to the active sites of COX-2 enzyme.	withaferin A	154-167	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	285-290
22713947-4	2012	In the present study we focus the extensive use of tool and graphical software for the identification of the binding energy of selected Withanolides like Withaferin -A, Withanolide-D from Withaniasomnifera and to screen the phytoconstituents that will dock/bind to the active sites of COX-2 enzyme.	withanolide D	169-182	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	285-290
22898640-10	2012	Strikingly, we also discovered that Sulindac (a COX-1/COX-2 inhibitor) or Celecoxib (a more specific COX-2 inhibitor) block xenograft tumorigenesis from pancreatic cancer cells expressing high levels of HMGA1.	Sulindac	36-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-59
22898640-10	2012	Strikingly, we also discovered that Sulindac (a COX-1/COX-2 inhibitor) or Celecoxib (a more specific COX-2 inhibitor) block xenograft tumorigenesis from pancreatic cancer cells expressing high levels of HMGA1.	Celecoxib	74-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-106
22522511-0	2012	Two new Co(II) coordination polymers based on carboxylate-bridged di- and trinuclear clusters with a pyridinedicarboxylate ligand: synthesis, structures and magnetism.	carboxylate	46-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	8-13
22522511-0	2012	Two new Co(II) coordination polymers based on carboxylate-bridged di- and trinuclear clusters with a pyridinedicarboxylate ligand: synthesis, structures and magnetism.	quinolinate(2-)	101-122	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	8-13
22522511-3	2012	Magnetic investigation indicates that besides strong spin-orbit coupling of Co(II) ions, ferromagnetic and weak ferromagnetic exchange interactions between Co(II) ions in the Co(2) and Co(3) clusters exist in 1 and 2, respectively.	co(2)	175-180	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	156-162
22522511-3	2012	Magnetic investigation indicates that besides strong spin-orbit coupling of Co(II) ions, ferromagnetic and weak ferromagnetic exchange interactions between Co(II) ions in the Co(2) and Co(3) clusters exist in 1 and 2, respectively.	co(3)	185-190	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	156-162
22543809-0	2012	Selective colorimetric sensing of Co(II) in aqueous media with a spiropyran-amide-dipicolylamine linkage under UV irradiation.	spiropyran-amide	65-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-40
22543809-0	2012	Selective colorimetric sensing of Co(II) in aqueous media with a spiropyran-amide-dipicolylamine linkage under UV irradiation.	2,2'-dipicolylamine	82-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-40
22719390-1	2012	The central Co(II) ion in the title complex, [Co(C(16)H(19)N(5))(2)](NO(3))(2), is located on a twofold rotation axis and has a slightly distorted octa-hedral coordination sphere.	co(c(16)h	46-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-18
22235849-6	2012	Induced mRNA and protein expression correlated with increased COX-2 activity, which led to increased levels of PGE(2) in the cell culture supernatant.	Dinoprostone	111-117	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
22235849-8	2012	CONCLUSION: Induction of COX-2 expression and activity and the consequent increased levels of prostaglandins are common inflammatory pathways in human cervicovaginal epithelial cells and tissues in response to diverse TLR ligands and pro-inflammatory cytokines.	Prostaglandins	94-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-30
22411700-5	2012	Enhanced level of COX-2 was observed following AO (0.1 mul/ml) and BY (0.1 mug/ml) treatment to cells for 24 h. AO treatment caused phosphorylation of ErbB2, AKT, ERK, and JNK along with increased thymidine uptake indicating cell proliferation ability in GB cells.	argemone oil	47-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-23
22411700-5	2012	Enhanced level of COX-2 was observed following AO (0.1 mul/ml) and BY (0.1 mug/ml) treatment to cells for 24 h. AO treatment caused phosphorylation of ErbB2, AKT, ERK, and JNK along with increased thymidine uptake indicating cell proliferation ability in GB cells.	Thymidine	197-206	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-23
22652668-0	2012	Imidazolineoxyl N-oxide induces COX-2 in endothelial cells:  role of free radicals.	imidazolineoxyl n-oxide	0-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-37
22652668-6	2012	cPTIO significantly increases the release of untransformed PGH2 associated to the induction of COX-2 expression.	Prostaglandin H2	59-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-100
21382956-7	2012	Furthermore, SFN and eugenol combinations at synergistic dose significantly downregulated the expression of Bcl-2, COX-2 and IL-beta but not the antagonistic combinations.	sulforaphane	13-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-120
21382956-7	2012	Furthermore, SFN and eugenol combinations at synergistic dose significantly downregulated the expression of Bcl-2, COX-2 and IL-beta but not the antagonistic combinations.	Eugenol	21-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-120
21424698-9	2012	Several associations were noted between single nucleotide polymorphisms in ribonucleotide reductase, Cox-2, vascular endothelial growth factor and survival in patients treated with gemcitabine and sorafenib.	gemcitabine	181-192	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-106
21424698-9	2012	Several associations were noted between single nucleotide polymorphisms in ribonucleotide reductase, Cox-2, vascular endothelial growth factor and survival in patients treated with gemcitabine and sorafenib.	Sorafenib	197-206	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-106
22528200-1	2012	The Co(II) complexes of twelve meso-tetraaryl-porphyrins, -chlorins, and chlorin analogues containing non-pyrrolic heterocycles were synthesized and converted in situ to the corresponding Co(III) complexes coordinated to one or two imidazoles.	meso-tetraaryl-porphyrins	31-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
22528200-1	2012	The Co(II) complexes of twelve meso-tetraaryl-porphyrins, -chlorins, and chlorin analogues containing non-pyrrolic heterocycles were synthesized and converted in situ to the corresponding Co(III) complexes coordinated to one or two imidazoles.	chlorin	59-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
22528200-1	2012	The Co(II) complexes of twelve meso-tetraaryl-porphyrins, -chlorins, and chlorin analogues containing non-pyrrolic heterocycles were synthesized and converted in situ to the corresponding Co(III) complexes coordinated to one or two imidazoles.	chlorin	59-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
22528200-1	2012	The Co(II) complexes of twelve meso-tetraaryl-porphyrins, -chlorins, and chlorin analogues containing non-pyrrolic heterocycles were synthesized and converted in situ to the corresponding Co(III) complexes coordinated to one or two imidazoles.	Imidazoles	232-242	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
21699460-1	2012	New hydrazone ligands (HL) derived from 5-substituted isatins and 1-(4-(2-methoxybenzyl)-6-arylpyridazin-3-yl)hydrazines and its complexes with Co(II) and Cu(II) were synthesized.	Hydrazones	4-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	144-150
21699460-1	2012	New hydrazone ligands (HL) derived from 5-substituted isatins and 1-(4-(2-methoxybenzyl)-6-arylpyridazin-3-yl)hydrazines and its complexes with Co(II) and Cu(II) were synthesized.	5-substituted isatins	40-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	144-150
21699460-1	2012	New hydrazone ligands (HL) derived from 5-substituted isatins and 1-(4-(2-methoxybenzyl)-6-arylpyridazin-3-yl)hydrazines and its complexes with Co(II) and Cu(II) were synthesized.	1-(4-(2-methoxybenzyl)-6-arylpyridazin-3-yl)hydrazines	66-120	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	144-150
21699460-1	2012	New hydrazone ligands (HL) derived from 5-substituted isatins and 1-(4-(2-methoxybenzyl)-6-arylpyridazin-3-yl)hydrazines and its complexes with Co(II) and Cu(II) were synthesized.	cu(ii)	155-161	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	144-150
22934333-11	2012	CONCLUSION: The difference of EOS infiltration in patients with ST may be associated with an inflammatory response underlying specific clinical manifestations after exposure to non-steroidal anti-inflammatory drugs, and the difference of COX-2 expression in patients with ST may be related to the conversion of metabolic pathway of arachidonic acid and the formation of nasal polyps.	Arachidonic Acid	332-348	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	238-243
23265037-1	2012	BACKGROUND: Etoricoxib, a selective Cox-2 inhibitor has been found to be effective in the management of acute pain.	Etoricoxib	12-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-41
22476027-0	2012	Two three-dimensional {V16Ge4}-based open frameworks stabilized by diverse types of Co(II)-amine bridges and magnetic properties.	v16ge4	23-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-89
22654430-1	2012	AIM: To investigate the ability of hexahydrocurcumin (HHC) to enhance 5-fluorouracil (5-FU) in inhibiting the growth of HT-29 cells by focusing on cyclooxygenase (COX)-2 expression.	hexahydrocurcumin	35-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-169
22654430-1	2012	AIM: To investigate the ability of hexahydrocurcumin (HHC) to enhance 5-fluorouracil (5-FU) in inhibiting the growth of HT-29 cells by focusing on cyclooxygenase (COX)-2 expression.	hexahydrocurcumin	54-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-169
22654430-9	2012	Semi-quantitative RT-PCR indicated that 5-FU at the concentration of 5 mumol/L in combination with HHC at the concentration of 25 mumol/L significantly down-regulates COX-2 mRNA expression when compared with values in cells treated with 5-FU or HHC alone (HHC + 5-FU: 31.93% +- 5.69%, 5-FU: 100.66% +- 4.52% vs HHC: 61.01% +- 0.35%, P &lt; 0.05).	Fluorouracil	40-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	167-172
22418687-5	2012	The utilisation of other Co(II) salt precursors gives rise to entirely different species including the mononuclear and trinuclear complexes [Co(II)(L(2))(2)] (5) and [Co(III)(2)Na(I)(1)(L(3))(6)](BF(4)) (6) (where L(3)H = 2-iminomethyl-4-bromo-6-methoxyphenol).	co(iii)	167-174	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-31
22418687-5	2012	The utilisation of other Co(II) salt precursors gives rise to entirely different species including the mononuclear and trinuclear complexes [Co(II)(L(2))(2)] (5) and [Co(III)(2)Na(I)(1)(L(3))(6)](BF(4)) (6) (where L(3)H = 2-iminomethyl-4-bromo-6-methoxyphenol).	2-iminomethyl-4-bromo-6-methoxyphenol	222-259	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-31
22590108-1	2012	The asymmetric unit of the polymeric title compound, [Co(C(7)H(4)IO(2))(2)(H(2)O)(2)](n), contains one Co(II) cation, two iodo-benzoate anions and two water mol-ecules.	co(c(7)h(4)io(2))	54-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-109
22451531-1	2012	Nimesulide is a selective COX-2 inhibitor that is as effective as the classical non-acidic nonsteroidal anti-inflammatory drugs in the relief of various pain and inflammatory conditions, but is better tolerated with lower incidences of adverse effects than other drugs.	nimesulide	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-31
21699540-2	2012	In patients with multiple sclerosis, COX-2 derived prostaglandins (PGs) are elevated in the CSF and COX-2 is up-regulated in demyelinating plaques.	Prostaglandins	51-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-42
21699540-2	2012	In patients with multiple sclerosis, COX-2 derived prostaglandins (PGs) are elevated in the CSF and COX-2 is up-regulated in demyelinating plaques.	Prostaglandins	67-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-42
21699540-4	2012	In cuprizone-induced demyelination, oligodendrocyte apoptosis and a concomitant increase in the gene expression of COX-2 and PGE2-EP2 receptor precede histological demyelination.	Cuprizone	3-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-120
21699540-6	2012	COX-2 gene deletion, chronic treatment with the COX-2 selective inhibitor celecoxib, or with the EP2 receptor antagonist AH6809 reduced cuprizone-induced oligodendrocyte apoptosis, the degree of demyelination and motor dysfunction.	Celecoxib	74-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-53
21699540-6	2012	COX-2 gene deletion, chronic treatment with the COX-2 selective inhibitor celecoxib, or with the EP2 receptor antagonist AH6809 reduced cuprizone-induced oligodendrocyte apoptosis, the degree of demyelination and motor dysfunction.	Cuprizone	136-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
21699540-6	2012	COX-2 gene deletion, chronic treatment with the COX-2 selective inhibitor celecoxib, or with the EP2 receptor antagonist AH6809 reduced cuprizone-induced oligodendrocyte apoptosis, the degree of demyelination and motor dysfunction.	Cuprizone	136-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-53
22450432-3	2012	For 4, structural and magnetochemical analysis indicate that the geometry of the octahedral Co(II) complex distorts to match that of the dominant Jahn-Teller distorted Cu(II) center.	cu(ii)	168-174	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-98
22450432-5	2012	Bond valence calculations have been used to estimate the relative stabilities of the six hydrogen bonded networks, suggesting that the stretching of the Co(II) coordination sphere 4 in is assisted by adoption of the most stable hydrogen bonded network; but that in 6 this is overcome by a higher loading of Co.	Hydrogen	89-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	153-158
22450432-5	2012	Bond valence calculations have been used to estimate the relative stabilities of the six hydrogen bonded networks, suggesting that the stretching of the Co(II) coordination sphere 4 in is assisted by adoption of the most stable hydrogen bonded network; but that in 6 this is overcome by a higher loading of Co.	Hydrogen	228-236	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	153-158
22354161-2	2012	Single crystal X-ray diffraction studies revealed that the Co(II) complex, {[Co(H(2)L)(H(2)O)(2)](NO(3))(2) 3H(2)O}(n) has a slightly distorted octahedral geometry around the central Co(II) ion; the ligand is coordinated through the ONO donor atoms to one Co(II) metal center and bridged through the pyridine nitrogen atom to another similar Co(II) center so as to form a one-dimensional polymeric unit.	co(h(2)	77-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
22354161-2	2012	Single crystal X-ray diffraction studies revealed that the Co(II) complex, {[Co(H(2)L)(H(2)O)(2)](NO(3))(2) 3H(2)O}(n) has a slightly distorted octahedral geometry around the central Co(II) ion; the ligand is coordinated through the ONO donor atoms to one Co(II) metal center and bridged through the pyridine nitrogen atom to another similar Co(II) center so as to form a one-dimensional polymeric unit.	co(h(2)	77-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	183-189
22354161-2	2012	Single crystal X-ray diffraction studies revealed that the Co(II) complex, {[Co(H(2)L)(H(2)O)(2)](NO(3))(2) 3H(2)O}(n) has a slightly distorted octahedral geometry around the central Co(II) ion; the ligand is coordinated through the ONO donor atoms to one Co(II) metal center and bridged through the pyridine nitrogen atom to another similar Co(II) center so as to form a one-dimensional polymeric unit.	Water	87-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	183-189
22354161-2	2012	Single crystal X-ray diffraction studies revealed that the Co(II) complex, {[Co(H(2)L)(H(2)O)(2)](NO(3))(2) 3H(2)O}(n) has a slightly distorted octahedral geometry around the central Co(II) ion; the ligand is coordinated through the ONO donor atoms to one Co(II) metal center and bridged through the pyridine nitrogen atom to another similar Co(II) center so as to form a one-dimensional polymeric unit.	co(h(2)	77-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	183-189
22354161-2	2012	Single crystal X-ray diffraction studies revealed that the Co(II) complex, {[Co(H(2)L)(H(2)O)(2)](NO(3))(2) 3H(2)O}(n) has a slightly distorted octahedral geometry around the central Co(II) ion; the ligand is coordinated through the ONO donor atoms to one Co(II) metal center and bridged through the pyridine nitrogen atom to another similar Co(II) center so as to form a one-dimensional polymeric unit.	Water	87-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	183-189
22354161-2	2012	Single crystal X-ray diffraction studies revealed that the Co(II) complex, {[Co(H(2)L)(H(2)O)(2)](NO(3))(2) 3H(2)O}(n) has a slightly distorted octahedral geometry around the central Co(II) ion; the ligand is coordinated through the ONO donor atoms to one Co(II) metal center and bridged through the pyridine nitrogen atom to another similar Co(II) center so as to form a one-dimensional polymeric unit.	punky blue	98-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
22354161-2	2012	Single crystal X-ray diffraction studies revealed that the Co(II) complex, {[Co(H(2)L)(H(2)O)(2)](NO(3))(2) 3H(2)O}(n) has a slightly distorted octahedral geometry around the central Co(II) ion; the ligand is coordinated through the ONO donor atoms to one Co(II) metal center and bridged through the pyridine nitrogen atom to another similar Co(II) center so as to form a one-dimensional polymeric unit.	co(h(2)	77-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	183-189
22354161-2	2012	Single crystal X-ray diffraction studies revealed that the Co(II) complex, {[Co(H(2)L)(H(2)O)(2)](NO(3))(2) 3H(2)O}(n) has a slightly distorted octahedral geometry around the central Co(II) ion; the ligand is coordinated through the ONO donor atoms to one Co(II) metal center and bridged through the pyridine nitrogen atom to another similar Co(II) center so as to form a one-dimensional polymeric unit.	punky blue	98-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	183-189
22354161-2	2012	Single crystal X-ray diffraction studies revealed that the Co(II) complex, {[Co(H(2)L)(H(2)O)(2)](NO(3))(2) 3H(2)O}(n) has a slightly distorted octahedral geometry around the central Co(II) ion; the ligand is coordinated through the ONO donor atoms to one Co(II) metal center and bridged through the pyridine nitrogen atom to another similar Co(II) center so as to form a one-dimensional polymeric unit.	punky blue	98-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	183-189
22354161-2	2012	Single crystal X-ray diffraction studies revealed that the Co(II) complex, {[Co(H(2)L)(H(2)O)(2)](NO(3))(2) 3H(2)O}(n) has a slightly distorted octahedral geometry around the central Co(II) ion; the ligand is coordinated through the ONO donor atoms to one Co(II) metal center and bridged through the pyridine nitrogen atom to another similar Co(II) center so as to form a one-dimensional polymeric unit.	Water	87-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
22354161-2	2012	Single crystal X-ray diffraction studies revealed that the Co(II) complex, {[Co(H(2)L)(H(2)O)(2)](NO(3))(2) 3H(2)O}(n) has a slightly distorted octahedral geometry around the central Co(II) ion; the ligand is coordinated through the ONO donor atoms to one Co(II) metal center and bridged through the pyridine nitrogen atom to another similar Co(II) center so as to form a one-dimensional polymeric unit.	punky blue	98-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	183-189
22354161-2	2012	Single crystal X-ray diffraction studies revealed that the Co(II) complex, {[Co(H(2)L)(H(2)O)(2)](NO(3))(2) 3H(2)O}(n) has a slightly distorted octahedral geometry around the central Co(II) ion; the ligand is coordinated through the ONO donor atoms to one Co(II) metal center and bridged through the pyridine nitrogen atom to another similar Co(II) center so as to form a one-dimensional polymeric unit.	Water	87-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	183-189
22354161-2	2012	Single crystal X-ray diffraction studies revealed that the Co(II) complex, {[Co(H(2)L)(H(2)O)(2)](NO(3))(2) 3H(2)O}(n) has a slightly distorted octahedral geometry around the central Co(II) ion; the ligand is coordinated through the ONO donor atoms to one Co(II) metal center and bridged through the pyridine nitrogen atom to another similar Co(II) center so as to form a one-dimensional polymeric unit.	) 3h(2)o	106-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
22354161-2	2012	Single crystal X-ray diffraction studies revealed that the Co(II) complex, {[Co(H(2)L)(H(2)O)(2)](NO(3))(2) 3H(2)O}(n) has a slightly distorted octahedral geometry around the central Co(II) ion; the ligand is coordinated through the ONO donor atoms to one Co(II) metal center and bridged through the pyridine nitrogen atom to another similar Co(II) center so as to form a one-dimensional polymeric unit.	Nitrogen Dioxide	233-236	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
22268508-0	2012	Involvement of PGE2 and the cAMP signalling pathway in the up-regulation of COX-2 and mPGES-1 expression in LPS-activated macrophages.	Dinoprostone	15-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-81
22354161-2	2012	Single crystal X-ray diffraction studies revealed that the Co(II) complex, {[Co(H(2)L)(H(2)O)(2)](NO(3))(2) 3H(2)O}(n) has a slightly distorted octahedral geometry around the central Co(II) ion; the ligand is coordinated through the ONO donor atoms to one Co(II) metal center and bridged through the pyridine nitrogen atom to another similar Co(II) center so as to form a one-dimensional polymeric unit.	pyridine	300-308	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
22354161-2	2012	Single crystal X-ray diffraction studies revealed that the Co(II) complex, {[Co(H(2)L)(H(2)O)(2)](NO(3))(2) 3H(2)O}(n) has a slightly distorted octahedral geometry around the central Co(II) ion; the ligand is coordinated through the ONO donor atoms to one Co(II) metal center and bridged through the pyridine nitrogen atom to another similar Co(II) center so as to form a one-dimensional polymeric unit.	Nitrogen	309-317	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
22354161-6	2012	Investigation of the antioxidative properties showed that the polymeric Co(II) complex has a strong radical scavenging potency against hydroxyl radicals, 2,2-diphenyl-1-picrylhydrazyl radicals, nitric oxide and superoxide anion radicals.	Hydroxyl Radical	135-152	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-78
22354161-6	2012	Investigation of the antioxidative properties showed that the polymeric Co(II) complex has a strong radical scavenging potency against hydroxyl radicals, 2,2-diphenyl-1-picrylhydrazyl radicals, nitric oxide and superoxide anion radicals.	2,2-diphenyl-1-picrylhydrazyl radicals	154-192	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-78
22354161-6	2012	Investigation of the antioxidative properties showed that the polymeric Co(II) complex has a strong radical scavenging potency against hydroxyl radicals, 2,2-diphenyl-1-picrylhydrazyl radicals, nitric oxide and superoxide anion radicals.	Nitric Oxide	194-206	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-78
22354161-6	2012	Investigation of the antioxidative properties showed that the polymeric Co(II) complex has a strong radical scavenging potency against hydroxyl radicals, 2,2-diphenyl-1-picrylhydrazyl radicals, nitric oxide and superoxide anion radicals.	Superoxides	211-236	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-78
22268508-0	2012	Involvement of PGE2 and the cAMP signalling pathway in the up-regulation of COX-2 and mPGES-1 expression in LPS-activated macrophages.	Cyclic AMP	28-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-81
22268508-3	2012	Our results show that PGE2 induces COX-2 and mPGES-1 expression, an effect mimicked by dbcAMP (dibutyryl-cAMP) or forskolin.	Dinoprostone	22-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40
22268508-3	2012	Our results show that PGE2 induces COX-2 and mPGES-1 expression, an effect mimicked by dbcAMP (dibutyryl-cAMP) or forskolin.	Bucladesine	87-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40
22268508-3	2012	Our results show that PGE2 induces COX-2 and mPGES-1 expression, an effect mimicked by dbcAMP (dibutyryl-cAMP) or forskolin.	Bucladesine	95-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40
22268508-4	2012	Furthermore, the cAMP signalling pathway co-operates with LPS (lipopolysaccharide) in the induction of COX-2 and mPGES-1 transcriptional activation.	Cyclic AMP	17-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-108
22268508-5	2012	Analysis of the involvement of PGE receptors [EPs (E-prostanoids)] showed that incubation with EP2 agonists up-regulated both COX2 and mPGES-1 mRNA levels.	eps	46-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-130
22268508-5	2012	Analysis of the involvement of PGE receptors [EPs (E-prostanoids)] showed that incubation with EP2 agonists up-regulated both COX2 and mPGES-1 mRNA levels.	e-prostanoids	51-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-130
22268508-8	2012	Activation of the PGE2/EP2/PKA signalling pathway induced the phosphorylation of CREB [CRE (cAMP-response element)-binding protein] in macrophages and stimulated the specific binding of this transcription factor to COX2 and mPGES-1 promoters.	Dinoprostone	18-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	215-219
22268508-8	2012	Activation of the PGE2/EP2/PKA signalling pathway induced the phosphorylation of CREB [CRE (cAMP-response element)-binding protein] in macrophages and stimulated the specific binding of this transcription factor to COX2 and mPGES-1 promoters.	Cyclic AMP	92-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	215-219
22268508-10	2012	In summary, the results of the present study demonstrate that activation of PKA/CREB signalling through the EP2 receptor by PGE2 plays a key role in the expression of COX-2 and mPGES-1 in activated macrophages.	Dinoprostone	124-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	167-172
22337603-0	2012	Highly-connected, porous coordination polymers based on [M4(mu3-OH)2] (M = Co(II) and Ni(II)) clusters: different networks, adsorption and magnetic properties.	Polymers	38-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-81
22366264-2	2012	We investigated the in vitro effects on cell proliferation, apoptosis, and COX-2 expression of the potential chemopreventives celecoxib and tauro-ursodeoxycholic acid (UDCA).	Celecoxib	126-135	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
22366264-2	2012	We investigated the in vitro effects on cell proliferation, apoptosis, and COX-2 expression of the potential chemopreventives celecoxib and tauro-ursodeoxycholic acid (UDCA).	ursodoxicoltaurine	140-166	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
22301678-2	2012	The reactions of CoX(2) (X = Cl(-), Br(-), I(-) and ClO(4)(-)) with the tripodal polypyridine N(4)O(2)-type ligand bearing pivalamide groups, bis(6-(pivalamide-2-pyridyl)methyl)(2-pyridylmethyl)amine ligand (H(2)BPPA), afforded two types of Co(II) complexes as follows.	Bromine	36-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-23
22394103-6	2012	These electrokinetic studies, combined with recent XAS studies of catalyst structure, suggest a mechanism for steady state growth at intermediate MeP(i) concentration (1.8-18 mM) involving a rapid solution equilibrium between aquo Co(II) and Co(III) hydroxo species accompanied with a rapid surface equilibrium involving electrolyte dissociation and deprotonation of surface bound water.	mep(i)	146-152	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	231-237
22301678-2	2012	The reactions of CoX(2) (X = Cl(-), Br(-), I(-) and ClO(4)(-)) with the tripodal polypyridine N(4)O(2)-type ligand bearing pivalamide groups, bis(6-(pivalamide-2-pyridyl)methyl)(2-pyridylmethyl)amine ligand (H(2)BPPA), afforded two types of Co(II) complexes as follows.	tripodal polypyridine n(4)o(2)	72-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-23
22301678-2	2012	The reactions of CoX(2) (X = Cl(-), Br(-), I(-) and ClO(4)(-)) with the tripodal polypyridine N(4)O(2)-type ligand bearing pivalamide groups, bis(6-(pivalamide-2-pyridyl)methyl)(2-pyridylmethyl)amine ligand (H(2)BPPA), afforded two types of Co(II) complexes as follows.	Pivalamide	123-133	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-23
22301678-2	2012	The reactions of CoX(2) (X = Cl(-), Br(-), I(-) and ClO(4)(-)) with the tripodal polypyridine N(4)O(2)-type ligand bearing pivalamide groups, bis(6-(pivalamide-2-pyridyl)methyl)(2-pyridylmethyl)amine ligand (H(2)BPPA), afforded two types of Co(II) complexes as follows.	bis(6-(pivalamide-2-pyridyl)methyl)(2-pyridylmethyl)amine	142-199	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-23
22301678-2	2012	The reactions of CoX(2) (X = Cl(-), Br(-), I(-) and ClO(4)(-)) with the tripodal polypyridine N(4)O(2)-type ligand bearing pivalamide groups, bis(6-(pivalamide-2-pyridyl)methyl)(2-pyridylmethyl)amine ligand (H(2)BPPA), afforded two types of Co(II) complexes as follows.	h(2)bppa	208-216	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-23
22301678-3	2012	One type is purple-coloured Co(II) complexes, [CoCl(2)(H(2)BPPA)] (1(Cl)) and [CoBr(2)(H(2)BPPA)] (1(Br)) which were prepared when X = Cl(-) and Br(-), respectively.	cobaltous chloride	47-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-34
22301678-3	2012	One type is purple-coloured Co(II) complexes, [CoCl(2)(H(2)BPPA)] (1(Cl)) and [CoBr(2)(H(2)BPPA)] (1(Br)) which were prepared when X = Cl(-) and Br(-), respectively.	h(2)bppa)	55-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-34
22301678-3	2012	One type is purple-coloured Co(II) complexes, [CoCl(2)(H(2)BPPA)] (1(Cl)) and [CoBr(2)(H(2)BPPA)] (1(Br)) which were prepared when X = Cl(-) and Br(-), respectively.	cobr(2)	79-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-34
22301678-3	2012	One type is purple-coloured Co(II) complexes, [CoCl(2)(H(2)BPPA)] (1(Cl)) and [CoBr(2)(H(2)BPPA)] (1(Br)) which were prepared when X = Cl(-) and Br(-), respectively.	h(2)bppa)	87-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-34
22301678-4	2012	The other type is pale pink-coloured Co(II) complexes, [Co(MeOH)(H(2)BPPA)](ClO(4)(-))(2) (2 (ClO(4)(-))(2)) and [Co(MeCN)(H(2)BPPA)](I(-))(2) (2 (I(-))(2)), which were obtained when X = I(-) and ClO(4)(-), respectively.	h(2)bppa)	65-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-43
22301678-4	2012	The other type is pale pink-coloured Co(II) complexes, [Co(MeOH)(H(2)BPPA)](ClO(4)(-))(2) (2 (ClO(4)(-))(2)) and [Co(MeCN)(H(2)BPPA)](I(-))(2) (2 (I(-))(2)), which were obtained when X = I(-) and ClO(4)(-), respectively.	perchlorate	76-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-43
22301678-4	2012	The other type is pale pink-coloured Co(II) complexes, [Co(MeOH)(H(2)BPPA)](ClO(4)(-))(2) (2 (ClO(4)(-))(2)) and [Co(MeCN)(H(2)BPPA)](I(-))(2) (2 (I(-))(2)), which were obtained when X = I(-) and ClO(4)(-), respectively.	co(mecn)	114-122	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-43
22301678-4	2012	The other type is pale pink-coloured Co(II) complexes, [Co(MeOH)(H(2)BPPA)](ClO(4)(-))(2) (2 (ClO(4)(-))(2)) and [Co(MeCN)(H(2)BPPA)](I(-))(2) (2 (I(-))(2)), which were obtained when X = I(-) and ClO(4)(-), respectively.	h(2)bppa	65-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-43
22301678-4	2012	The other type is pale pink-coloured Co(II) complexes, [Co(MeOH)(H(2)BPPA)](ClO(4)(-))(2) (2 (ClO(4)(-))(2)) and [Co(MeCN)(H(2)BPPA)](I(-))(2) (2 (I(-))(2)), which were obtained when X = I(-) and ClO(4)(-), respectively.	clo	76-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-43
22301678-8	2012	The former Co(II) complexes revealed a six-coordinate octahedron with one amine nitrogen, three pyridyl nitrogens, and two counter anions, and one coordinated anion, Cl(-), Br(-) and N(3)(-), forming intramolecular hydrogen bonds with two pivalamide N-H groups.	octahedron	54-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-17
22301678-8	2012	The former Co(II) complexes revealed a six-coordinate octahedron with one amine nitrogen, three pyridyl nitrogens, and two counter anions, and one coordinated anion, Cl(-), Br(-) and N(3)(-), forming intramolecular hydrogen bonds with two pivalamide N-H groups.	Amines	74-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-17
22301678-8	2012	The former Co(II) complexes revealed a six-coordinate octahedron with one amine nitrogen, three pyridyl nitrogens, and two counter anions, and one coordinated anion, Cl(-), Br(-) and N(3)(-), forming intramolecular hydrogen bonds with two pivalamide N-H groups.	Nitrogen	80-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-17
22301678-8	2012	The former Co(II) complexes revealed a six-coordinate octahedron with one amine nitrogen, three pyridyl nitrogens, and two counter anions, and one coordinated anion, Cl(-), Br(-) and N(3)(-), forming intramolecular hydrogen bonds with two pivalamide N-H groups.	Nitrogen	104-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-17
22301678-8	2012	The former Co(II) complexes revealed a six-coordinate octahedron with one amine nitrogen, three pyridyl nitrogens, and two counter anions, and one coordinated anion, Cl(-), Br(-) and N(3)(-), forming intramolecular hydrogen bonds with two pivalamide N-H groups.	Bromine	173-175	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-17
22301678-8	2012	The former Co(II) complexes revealed a six-coordinate octahedron with one amine nitrogen, three pyridyl nitrogens, and two counter anions, and one coordinated anion, Cl(-), Br(-) and N(3)(-), forming intramolecular hydrogen bonds with two pivalamide N-H groups.	Hydrogen	215-223	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-17
22301678-8	2012	The former Co(II) complexes revealed a six-coordinate octahedron with one amine nitrogen, three pyridyl nitrogens, and two counter anions, and one coordinated anion, Cl(-), Br(-) and N(3)(-), forming intramolecular hydrogen bonds with two pivalamide N-H groups.	Pivalamide	239-249	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-17
22301678-9	2012	On the other hand, the latter Co(II) complexes showed a seven-coordinate face-capped octahedron with one amine nitrogen, three pyridyl nitrogens, two pivalamide carbonyl oxygens and MeCN or MeOH.	octahedron	85-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-36
22301678-9	2012	On the other hand, the latter Co(II) complexes showed a seven-coordinate face-capped octahedron with one amine nitrogen, three pyridyl nitrogens, two pivalamide carbonyl oxygens and MeCN or MeOH.	Amines	105-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-36
22301678-9	2012	On the other hand, the latter Co(II) complexes showed a seven-coordinate face-capped octahedron with one amine nitrogen, three pyridyl nitrogens, two pivalamide carbonyl oxygens and MeCN or MeOH.	Nitrogen	111-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-36
22301678-9	2012	On the other hand, the latter Co(II) complexes showed a seven-coordinate face-capped octahedron with one amine nitrogen, three pyridyl nitrogens, two pivalamide carbonyl oxygens and MeCN or MeOH.	Nitrogen	135-144	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-36
22301678-9	2012	On the other hand, the latter Co(II) complexes showed a seven-coordinate face-capped octahedron with one amine nitrogen, three pyridyl nitrogens, two pivalamide carbonyl oxygens and MeCN or MeOH.	Oxygen	170-177	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-36
22301678-9	2012	On the other hand, the latter Co(II) complexes showed a seven-coordinate face-capped octahedron with one amine nitrogen, three pyridyl nitrogens, two pivalamide carbonyl oxygens and MeCN or MeOH.	acetonitrile	182-186	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-36
22301678-9	2012	On the other hand, the latter Co(II) complexes showed a seven-coordinate face-capped octahedron with one amine nitrogen, three pyridyl nitrogens, two pivalamide carbonyl oxygens and MeCN or MeOH.	Methanol	190-194	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-36
22301678-13	2012	Also, the abstraction reaction of halogen anions from complexes 1(Cl) by AgSbF(6) gave a pale pink Co(II) complex assignable to 2 (SbF(6)(-))(2).	Halogens	34-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-105
22411760-0	2012	Noble metal-free oxidative electrocatalysts: polyaniline and Co(II)-polyaniline nanostructures hosted in nanoporous silica.	Metals	6-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-67
22411760-0	2012	Noble metal-free oxidative electrocatalysts: polyaniline and Co(II)-polyaniline nanostructures hosted in nanoporous silica.	polyaniline	68-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-67
22411760-0	2012	Noble metal-free oxidative electrocatalysts: polyaniline and Co(II)-polyaniline nanostructures hosted in nanoporous silica.	Silicon Dioxide	116-122	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-67
22411760-2	2012	The resulting PANI/SBA-15 is capable of chelating Co(II) ions, presumably via its nitrogen atoms on PANI/diamine groups.	polyaniline	14-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-56
22411760-2	2012	The resulting PANI/SBA-15 is capable of chelating Co(II) ions, presumably via its nitrogen atoms on PANI/diamine groups.	SBA-15	19-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-56
22411760-2	2012	The resulting PANI/SBA-15 is capable of chelating Co(II) ions, presumably via its nitrogen atoms on PANI/diamine groups.	Nitrogen	82-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-56
22411760-2	2012	The resulting PANI/SBA-15 is capable of chelating Co(II) ions, presumably via its nitrogen atoms on PANI/diamine groups.	polyaniline	100-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-56
22411760-2	2012	The resulting PANI/SBA-15 is capable of chelating Co(II) ions, presumably via its nitrogen atoms on PANI/diamine groups.	Diamines	105-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-56
22411760-3	2012	Both the metal-free (SBA-15/PANI) and the Co(II)-doped SBA-15/PANI nanocomposite materials showed high electrocatalytic activity for oxidation of L-ascorbic acid, with very low overpotential and high current density.	Metals	9-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-48
22411760-3	2012	Both the metal-free (SBA-15/PANI) and the Co(II)-doped SBA-15/PANI nanocomposite materials showed high electrocatalytic activity for oxidation of L-ascorbic acid, with very low overpotential and high current density.	SBA-15	21-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-48
22411760-3	2012	Both the metal-free (SBA-15/PANI) and the Co(II)-doped SBA-15/PANI nanocomposite materials showed high electrocatalytic activity for oxidation of L-ascorbic acid, with very low overpotential and high current density.	polyaniline	28-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-48
22411760-3	2012	Both the metal-free (SBA-15/PANI) and the Co(II)-doped SBA-15/PANI nanocomposite materials showed high electrocatalytic activity for oxidation of L-ascorbic acid, with very low overpotential and high current density.	SBA-15	55-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-48
22411760-3	2012	Both the metal-free (SBA-15/PANI) and the Co(II)-doped SBA-15/PANI nanocomposite materials showed high electrocatalytic activity for oxidation of L-ascorbic acid, with very low overpotential and high current density.	Ascorbic Acid	146-161	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-48
22329897-1	2012	Increases in the level of cyclooxygenase (COX)-2 and prostanoids such as prostaglandin E(2) (PGE(2)) are considered biomarkers of colorectal cancer.	Dinoprostone	93-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-48
22428925-0	2012	Combination of magnetic susceptibility and electron paramagnetic resonance to monitor the 1D to 2D solid state transformation in flexible metal-organic frameworks of Co(II) and Zn(II) with 1,4-bis(triazol-1-ylmethyl)benzene.	Metals	138-143	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	166-172
22428925-0	2012	Combination of magnetic susceptibility and electron paramagnetic resonance to monitor the 1D to 2D solid state transformation in flexible metal-organic frameworks of Co(II) and Zn(II) with 1,4-bis(triazol-1-ylmethyl)benzene.	1,4-bis(triazol-1-ylmethyl)benzene	189-223	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	166-172
22431597-4	2012	Methylation of CoFeSP only occurs in the low-potential Co(I) state, which can be sporadically oxidized to the inactive Co(II) state, making its reductive reactivation necessary.	NAD	55-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-125
23552603-4	2012	In addition to our previous studies demonstrating COX-2/PGE2"s role in transcriptional regulation of KSHV latency promoter and latent gene expression, the current study adds to the complexity that though LANA-1 (latency associated nuclear antigen) is utilizing COX-2/PGE2 as critical factors for its transcriptional regulation, it is the v-FLIP/K13 gene in the KSHV latency cluster that maintains continuous COX-2/PGE2 levels in the infected cells.	Dinoprostone	267-271	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-55
23552603-4	2012	In addition to our previous studies demonstrating COX-2/PGE2"s role in transcriptional regulation of KSHV latency promoter and latent gene expression, the current study adds to the complexity that though LANA-1 (latency associated nuclear antigen) is utilizing COX-2/PGE2 as critical factors for its transcriptional regulation, it is the v-FLIP/K13 gene in the KSHV latency cluster that maintains continuous COX-2/PGE2 levels in the infected cells.	Dinoprostone	267-271	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-55
23552603-5	2012	We demonstrate that COX-2 inhibition, via its chemical inhibitors (NS-398 or celecoxib), reduced v-FLIP/K13-mediated NF-kappaB induction, and extracellular matrix (ECM) interaction-mediated signaling, mitochondrial antioxidant enzyme manganese superoxide dismutase (MnSOD) levels, and subsequently downregulated detachment-induced apoptosis (anoikis) resistance.	Celecoxib	77-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-25
23552603-5	2012	We demonstrate that COX-2 inhibition, via its chemical inhibitors (NS-398 or celecoxib), reduced v-FLIP/K13-mediated NF-kappaB induction, and extracellular matrix (ECM) interaction-mediated signaling, mitochondrial antioxidant enzyme manganese superoxide dismutase (MnSOD) levels, and subsequently downregulated detachment-induced apoptosis (anoikis) resistance.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	67-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-25
22306363-2	2012	Here we investigated the role of COXs (cyclooxygenases) in these effects and we found that, i) ATRA increased the expression of COX-1 and COX-2 mRNA and protein and the intracellular levels (but not the extracellular ones) of PGE(2).	Tretinoin	95-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	138-143
22589841-5	2012	Strongly tight, via one intra-molecular hydrogen bond between aqua and carboxyl-ate O atoms, it brings out a quasi-planar six-membered ring around the Co(II) atom, turning the CoN(3)O(3) coordination octa-hedron into a new building block.	Hydrogen	40-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-157
22589841-5	2012	Strongly tight, via one intra-molecular hydrogen bond between aqua and carboxyl-ate O atoms, it brings out a quasi-planar six-membered ring around the Co(II) atom, turning the CoN(3)O(3) coordination octa-hedron into a new building block.	carboxyl-ate o	71-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-157
22589841-5	2012	Strongly tight, via one intra-molecular hydrogen bond between aqua and carboxyl-ate O atoms, it brings out a quasi-planar six-membered ring around the Co(II) atom, turning the CoN(3)O(3) coordination octa-hedron into a new building block.	octa-hedron	200-211	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-157
22589841-7	2012	In the resulting supra-molecular packing, a binuclear hydrated Co(II) assembly, built up from triple strands driven by different heterosynthons, embodies the synergy of coordination, covalent and hydrogen bonds.	Hydrogen	196-204	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-69
22342562-3	2012	Those which were most affected by the addition of this metal ion were lactate &gt; formate  histidinate &gt; succinate, this order reflecting the ability of these complexants to compete for the available Co(II) in terms of (1) thermodynamic equilibrium constants for the formation of their complexes and (2) their HSS concentrations.	Metals	55-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	204-210
22342562-3	2012	Those which were most affected by the addition of this metal ion were lactate &gt; formate  histidinate &gt; succinate, this order reflecting the ability of these complexants to compete for the available Co(II) in terms of (1) thermodynamic equilibrium constants for the formation of their complexes and (2) their HSS concentrations.	Lactic Acid	70-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	204-210
22342562-3	2012	Those which were most affected by the addition of this metal ion were lactate &gt; formate  histidinate &gt; succinate, this order reflecting the ability of these complexants to compete for the available Co(II) in terms of (1) thermodynamic equilibrium constants for the formation of their complexes and (2) their HSS concentrations.	Succinic Acid	109-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	204-210
22342562-3	2012	Those which were most affected by the addition of this metal ion were lactate &gt; formate  histidinate &gt; succinate, this order reflecting the ability of these complexants to compete for the available Co(II) in terms of (1) thermodynamic equilibrium constants for the formation of their complexes and (2) their HSS concentrations.	hepatic stimulator substance	314-317	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	204-210
22342562-4	2012	Since many of these HSS Co(II) complexants (particularly lactate, formate and histidine) serve as powerful ()OH scavengers, the results acquired indicate that any of this radical generated from the Co(II) source in such complexes via pseudo-Fenton reactions may be "site-specifically" scavenged.	Lactic Acid	57-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-30
22342562-4	2012	Since many of these HSS Co(II) complexants (particularly lactate, formate and histidine) serve as powerful ()OH scavengers, the results acquired indicate that any of this radical generated from the Co(II) source in such complexes via pseudo-Fenton reactions may be "site-specifically" scavenged.	Lactic Acid	57-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	198-204
22342562-4	2012	Since many of these HSS Co(II) complexants (particularly lactate, formate and histidine) serve as powerful ()OH scavengers, the results acquired indicate that any of this radical generated from the Co(II) source in such complexes via pseudo-Fenton reactions may be "site-specifically" scavenged.	formic acid	66-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-30
22342562-4	2012	Since many of these HSS Co(II) complexants (particularly lactate, formate and histidine) serve as powerful ()OH scavengers, the results acquired indicate that any of this radical generated from the Co(II) source in such complexes via pseudo-Fenton reactions may be "site-specifically" scavenged.	formic acid	66-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	198-204
22342562-4	2012	Since many of these HSS Co(II) complexants (particularly lactate, formate and histidine) serve as powerful ()OH scavengers, the results acquired indicate that any of this radical generated from the Co(II) source in such complexes via pseudo-Fenton reactions may be "site-specifically" scavenged.	Histidine	78-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-30
22342562-4	2012	Since many of these HSS Co(II) complexants (particularly lactate, formate and histidine) serve as powerful ()OH scavengers, the results acquired indicate that any of this radical generated from the Co(II) source in such complexes via pseudo-Fenton reactions may be "site-specifically" scavenged.	Histidine	78-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	198-204
22386242-0	2012	N-Caffeoyl serotonin as selective COX-2 inhibitor.	N-caffeoylserotonin	0-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-39
22386242-5	2012	Caffeic acid and N-caffeoyl serotonin (4) exhibited selective inhibition of COX-2 compared to aspirin.	caffeic acid	0-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-81
22386242-5	2012	Caffeic acid and N-caffeoyl serotonin (4) exhibited selective inhibition of COX-2 compared to aspirin.	N-caffeoylserotonin	17-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-81
22386242-6	2012	Comparison caffeic acid with 4 suggested that the linkage of caffeic acid and serotonin enhance COX-2 inhibition.	caffeic acid	11-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-101
22386242-6	2012	Comparison caffeic acid with 4 suggested that the linkage of caffeic acid and serotonin enhance COX-2 inhibition.	caffeic acid	61-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-101
22386242-6	2012	Comparison caffeic acid with 4 suggested that the linkage of caffeic acid and serotonin enhance COX-2 inhibition.	Serotonin	78-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-101
22386242-7	2012	Comparison of structures of caffeic acid and sinapic acid implied that catechol moiety of cinnamic acid derivatives is a major contributing factor for selective inhibition of COX-2.	caffeic acid	28-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	175-180
22386242-7	2012	Comparison of structures of caffeic acid and sinapic acid implied that catechol moiety of cinnamic acid derivatives is a major contributing factor for selective inhibition of COX-2.	sinapinic acid	45-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	175-180
22386242-7	2012	Comparison of structures of caffeic acid and sinapic acid implied that catechol moiety of cinnamic acid derivatives is a major contributing factor for selective inhibition of COX-2.	catechol	71-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	175-180
22386242-7	2012	Comparison of structures of caffeic acid and sinapic acid implied that catechol moiety of cinnamic acid derivatives is a major contributing factor for selective inhibition of COX-2.	cinnamic acid	90-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	175-180
22221151-21	2012	Sumatriptan acts on the 5-HT(1B) and 5-HT(1D) receptors, whereas naproxen inhibits the COX-1 and COX-2 enzymes.	Naproxen	65-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
22373734-4	2012	Furthermore, COX-2 contribution to PGE(2) and PGI(2) production evokes and sustains systemic or peripheral inflammatory disease, but it is not involved in the COX-1-mediated GI tract events.	Prostaglandins E	35-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
22373734-4	2012	Furthermore, COX-2 contribution to PGE(2) and PGI(2) production evokes and sustains systemic or peripheral inflammatory disease, but it is not involved in the COX-1-mediated GI tract events.	Epoprostenol	46-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
22373734-7	2012	In this study, a series of novel [2-{[(4-substituted or 4,5-disubstituted)-pyridin-2-yl]carbonyl}-(5- or 6-substituted or 5,6-disubstituted)-1H-indol-3-yl]acetic acid analogues was designed, synthesized, and evaluated to identify potent and selective COX-2 inhibitors as potential agents against inflammatory diseases.	[2-{[(4-substituted or 4,5-disubstituted)-pyridin-2-yl]carbonyl}-(5- or 6-substituted	33-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	251-256
22373734-7	2012	In this study, a series of novel [2-{[(4-substituted or 4,5-disubstituted)-pyridin-2-yl]carbonyl}-(5- or 6-substituted or 5,6-disubstituted)-1H-indol-3-yl]acetic acid analogues was designed, synthesized, and evaluated to identify potent and selective COX-2 inhibitors as potential agents against inflammatory diseases.	5,6-disubstituted)-1h-indol-3-yl]acetic acid	122-166	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	251-256
21848948-3	2012	Etoricoxib, a Cox-2 inhibitor with a 22-hour half-life, has been shown effective in preventing fasting headache when taken just prior to the 25-hour Yom Kippur fast.	Etoricoxib	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
22308510-3	2012	We observed an enhanced production of PGE(2) in cocultures of HNSCC cell lines and fibroblasts, which was consistent with an upregulation of COX-2 and microsomal PGE-synthase-1 (mPGES-1) in fibroblasts.	Prostaglandins E	38-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	141-146
22406532-4	2012	NSAID-mediated suppression of COX-2-derived PGI2 has negative cardiovascular consequences, yet little is known about the cardiovascular biology of PGD2.	Epoprostenol	44-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-35
22406532-7	2012	Furthermore, COX inhibitors in humans, as well as platelet depletion, COX-1 knockdown, and COX-2 deletion in mice, revealed that niacin evoked platelet COX-1-derived PGD2 biosynthesis.	Niacin	129-135	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-96
23717114-7	2012	Furthermore, the ginsenosides Rd and Km inhibited the TNF-alpha-induced expression levels of the COX-2 and iNOS gene in HepG2 cells.	Ginsenosides	17-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
23717114-8	2012	Air-dried leaf extracts and their chemical components, ginsenoside Rd and Km, are involved in the suppression of TNF-alpha-induced NF-kappaB activation and NF-kappaB-dependent iNOS and COX-2 gene expression.	Ginsenosides	55-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	185-190
22262921-2	2012	Thus, a profound inhibition of COX-2-dependent PGI(2) might be associated with changes in circulating markers of angiogenesis.	Prostaglandins I	47-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-36
22410675-1	2012	Five primary prostanoids are synthesized by the cyclooxygenase enzymes, COX-1 and COX-2: the prostaglandins PGE(2), PGF(2alpha), PGI(2), PGD(2) and thromboxane A2.	Prostaglandins	13-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
22410675-1	2012	Five primary prostanoids are synthesized by the cyclooxygenase enzymes, COX-1 and COX-2: the prostaglandins PGE(2), PGF(2alpha), PGI(2), PGD(2) and thromboxane A2.	Prostaglandins	93-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
22410675-1	2012	Five primary prostanoids are synthesized by the cyclooxygenase enzymes, COX-1 and COX-2: the prostaglandins PGE(2), PGF(2alpha), PGI(2), PGD(2) and thromboxane A2.	Prostaglandins E	108-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
22410675-1	2012	Five primary prostanoids are synthesized by the cyclooxygenase enzymes, COX-1 and COX-2: the prostaglandins PGE(2), PGF(2alpha), PGI(2), PGD(2) and thromboxane A2.	Prostaglandins F	116-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
22410675-1	2012	Five primary prostanoids are synthesized by the cyclooxygenase enzymes, COX-1 and COX-2: the prostaglandins PGE(2), PGF(2alpha), PGI(2), PGD(2) and thromboxane A2.	Prostaglandins I	129-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
22410675-1	2012	Five primary prostanoids are synthesized by the cyclooxygenase enzymes, COX-1 and COX-2: the prostaglandins PGE(2), PGF(2alpha), PGI(2), PGD(2) and thromboxane A2.	Prostaglandins D	137-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
22410675-1	2012	Five primary prostanoids are synthesized by the cyclooxygenase enzymes, COX-1 and COX-2: the prostaglandins PGE(2), PGF(2alpha), PGI(2), PGD(2) and thromboxane A2.	Thromboxane A2	148-162	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
22406590-7	2012	Abstract #253 takes this one step further and evaluates gemcitabine and erlotinib with apricoxib, a COX-2 inhibitor.	gemcitabine	56-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-105
22406590-7	2012	Abstract #253 takes this one step further and evaluates gemcitabine and erlotinib with apricoxib, a COX-2 inhibitor.	Erlotinib Hydrochloride	72-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-105
22406590-7	2012	Abstract #253 takes this one step further and evaluates gemcitabine and erlotinib with apricoxib, a COX-2 inhibitor.	apricoxib	87-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-105
22263894-2	2012	They are produced by oxidation of arachidonic acid (AA) by cyclooxygenases (COX-1 and COX-2) followed by metabolism of endoperoxide intermediates by terminal PG synthases.	Arachidonic Acid	34-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-91
22223134-1	2012	By auxiliary N-donor ligand-directed assembled, two entangled Co(II)-coordination nets have been constructed from 3,3",5,5"-azobenzenetetracarboxylic acid (H(4)abtc), which present a rare 2D 3D polythreading motif constructed from 2-fold (6,3) polymeric layers with thickness being 10.2 A and a 3-fold interpenetrating pillar-layered framework based on linear trinuclear Co(II)-SBUs.	3,3",5,5"-azobenzenetetracarboxylic acid	114-154	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-68
22223134-1	2012	By auxiliary N-donor ligand-directed assembled, two entangled Co(II)-coordination nets have been constructed from 3,3",5,5"-azobenzenetetracarboxylic acid (H(4)abtc), which present a rare 2D 3D polythreading motif constructed from 2-fold (6,3) polymeric layers with thickness being 10.2 A and a 3-fold interpenetrating pillar-layered framework based on linear trinuclear Co(II)-SBUs.	3,3",5,5"-azobenzenetetracarboxylic acid	114-154	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	371-377
22223134-1	2012	By auxiliary N-donor ligand-directed assembled, two entangled Co(II)-coordination nets have been constructed from 3,3",5,5"-azobenzenetetracarboxylic acid (H(4)abtc), which present a rare 2D 3D polythreading motif constructed from 2-fold (6,3) polymeric layers with thickness being 10.2 A and a 3-fold interpenetrating pillar-layered framework based on linear trinuclear Co(II)-SBUs.	h(4)abtc	156-164	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-68
22223134-1	2012	By auxiliary N-donor ligand-directed assembled, two entangled Co(II)-coordination nets have been constructed from 3,3",5,5"-azobenzenetetracarboxylic acid (H(4)abtc), which present a rare 2D 3D polythreading motif constructed from 2-fold (6,3) polymeric layers with thickness being 10.2 A and a 3-fold interpenetrating pillar-layered framework based on linear trinuclear Co(II)-SBUs.	h(4)abtc	156-164	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	371-377
22299646-5	2012	The protonation of Co(II)(Ph(8)Pc) inhibits the direct reduction of O(2); however, the proton-coupled electron transfer from Me(10)Fc to Co(II)(Ph(8)Pc) and the protonated [Co(II)(Ph(8)PcH)](+) occurs to produce Co(I)(Ph(8)PcH) and [Co(I)(Ph(8)PcH(2))](+), respectively, which react immediately with O(2).	poly(ethylene oxide)-b-poly(alpha-cholesteryl carboxylate-epsilon-caprolactone) block copolymer	185-188	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-143
22299646-5	2012	The protonation of Co(II)(Ph(8)Pc) inhibits the direct reduction of O(2); however, the proton-coupled electron transfer from Me(10)Fc to Co(II)(Ph(8)Pc) and the protonated [Co(II)(Ph(8)PcH)](+) occurs to produce Co(I)(Ph(8)PcH) and [Co(I)(Ph(8)PcH(2))](+), respectively, which react immediately with O(2).	Oxygen	300-304	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-25
22299646-5	2012	The protonation of Co(II)(Ph(8)Pc) inhibits the direct reduction of O(2); however, the proton-coupled electron transfer from Me(10)Fc to Co(II)(Ph(8)Pc) and the protonated [Co(II)(Ph(8)PcH)](+) occurs to produce Co(I)(Ph(8)PcH) and [Co(I)(Ph(8)PcH(2))](+), respectively, which react immediately with O(2).	Oxygen	300-304	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-143
22299646-5	2012	The protonation of Co(II)(Ph(8)Pc) inhibits the direct reduction of O(2); however, the proton-coupled electron transfer from Me(10)Fc to Co(II)(Ph(8)Pc) and the protonated [Co(II)(Ph(8)PcH)](+) occurs to produce Co(I)(Ph(8)PcH) and [Co(I)(Ph(8)PcH(2))](+), respectively, which react immediately with O(2).	Oxygen	300-304	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-143
22299646-6	2012	The rate-determining step is a proton-coupled electron-transfer reduction of O(2) by Co(II)(Ph(8)Pc) in the Co(II)(Ph(8)Pc)-catalyzed cycle with Me(2)Fc, whereas it is changed to the electron-transfer reduction of [Co(II)(Ph(8)PcH)](+) by Me(10)Fc in the Co(I)(Ph(8)PcH)-catalyzed cycle with Me(10)Fc.	Oxygen	77-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-91
22299646-6	2012	The rate-determining step is a proton-coupled electron-transfer reduction of O(2) by Co(II)(Ph(8)Pc) in the Co(II)(Ph(8)Pc)-catalyzed cycle with Me(2)Fc, whereas it is changed to the electron-transfer reduction of [Co(II)(Ph(8)PcH)](+) by Me(10)Fc in the Co(I)(Ph(8)PcH)-catalyzed cycle with Me(10)Fc.	Oxygen	77-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-114
22299646-6	2012	The rate-determining step is a proton-coupled electron-transfer reduction of O(2) by Co(II)(Ph(8)Pc) in the Co(II)(Ph(8)Pc)-catalyzed cycle with Me(2)Fc, whereas it is changed to the electron-transfer reduction of [Co(II)(Ph(8)PcH)](+) by Me(10)Fc in the Co(I)(Ph(8)PcH)-catalyzed cycle with Me(10)Fc.	Oxygen	77-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-114
22299646-6	2012	The rate-determining step is a proton-coupled electron-transfer reduction of O(2) by Co(II)(Ph(8)Pc) in the Co(II)(Ph(8)Pc)-catalyzed cycle with Me(2)Fc, whereas it is changed to the electron-transfer reduction of [Co(II)(Ph(8)PcH)](+) by Me(10)Fc in the Co(I)(Ph(8)PcH)-catalyzed cycle with Me(10)Fc.	pch)	227-231	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-91
22299646-6	2012	The rate-determining step is a proton-coupled electron-transfer reduction of O(2) by Co(II)(Ph(8)Pc) in the Co(II)(Ph(8)Pc)-catalyzed cycle with Me(2)Fc, whereas it is changed to the electron-transfer reduction of [Co(II)(Ph(8)PcH)](+) by Me(10)Fc in the Co(I)(Ph(8)PcH)-catalyzed cycle with Me(10)Fc.	pch)	227-231	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-114
22299646-6	2012	The rate-determining step is a proton-coupled electron-transfer reduction of O(2) by Co(II)(Ph(8)Pc) in the Co(II)(Ph(8)Pc)-catalyzed cycle with Me(2)Fc, whereas it is changed to the electron-transfer reduction of [Co(II)(Ph(8)PcH)](+) by Me(10)Fc in the Co(I)(Ph(8)PcH)-catalyzed cycle with Me(10)Fc.	pch)	227-231	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-114
22299646-6	2012	The rate-determining step is a proton-coupled electron-transfer reduction of O(2) by Co(II)(Ph(8)Pc) in the Co(II)(Ph(8)Pc)-catalyzed cycle with Me(2)Fc, whereas it is changed to the electron-transfer reduction of [Co(II)(Ph(8)PcH)](+) by Me(10)Fc in the Co(I)(Ph(8)PcH)-catalyzed cycle with Me(10)Fc.	poly(ethylene oxide)-b-poly(alpha-cholesteryl carboxylate-epsilon-caprolactone) block copolymer	227-230	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-91
22299646-6	2012	The rate-determining step is a proton-coupled electron-transfer reduction of O(2) by Co(II)(Ph(8)Pc) in the Co(II)(Ph(8)Pc)-catalyzed cycle with Me(2)Fc, whereas it is changed to the electron-transfer reduction of [Co(II)(Ph(8)PcH)](+) by Me(10)Fc in the Co(I)(Ph(8)PcH)-catalyzed cycle with Me(10)Fc.	poly(ethylene oxide)-b-poly(alpha-cholesteryl carboxylate-epsilon-caprolactone) block copolymer	227-230	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-114
22299646-6	2012	The rate-determining step is a proton-coupled electron-transfer reduction of O(2) by Co(II)(Ph(8)Pc) in the Co(II)(Ph(8)Pc)-catalyzed cycle with Me(2)Fc, whereas it is changed to the electron-transfer reduction of [Co(II)(Ph(8)PcH)](+) by Me(10)Fc in the Co(I)(Ph(8)PcH)-catalyzed cycle with Me(10)Fc.	poly(ethylene oxide)-b-poly(alpha-cholesteryl carboxylate-epsilon-caprolactone) block copolymer	227-230	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-114
22198215-9	2012	In addition, 5-ASA also significantly changed expression of the downstream targets Cox2, cyclin D1 and E-cadherin, correlating with ss-catenin status.	5-Aminosalicylic acid	13-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-87
21507199-11	2012	Studies showed involvement of ERK, p38 and COX-2 pathways in high IL-10 production, driven by lung tumour derived PGE2.	Dinoprostone	114-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
21507199-12	2012	The selective COX-2 inhibitor rofecoxib showed ability to alter the cytokine balance by affecting regulation of T-bet and GATA-3 transcription factors.	rofecoxib	30-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
22089456-10	2012	GS inhibits PGE(2) synthesis through reduction in the activity of COX-2 and the production and activity of mPGES-1.	Glucosamine	0-2	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-71
22089456-10	2012	GS inhibits PGE(2) synthesis through reduction in the activity of COX-2 and the production and activity of mPGES-1.	Dinoprostone	12-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-71
22134498-2	2012	Speciation of cobalt active sites into Co(II), mono- and polynuclear oxo-cobalt species as well as CoO clusters was quantified by IR using CO and NO as probe molecules.	Cobalt	14-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-45
22134498-4	2012	Based on the spectroscopic operando results, a concise mechanistic scheme of the selective catalytic reduction of nitric oxide by propene, triggered by a two-electron Co(II)/Co(0) redox couple, was developed.	Nitric Oxide	114-126	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	167-173
22134498-4	2012	Based on the spectroscopic operando results, a concise mechanistic scheme of the selective catalytic reduction of nitric oxide by propene, triggered by a two-electron Co(II)/Co(0) redox couple, was developed.	propylene	130-137	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	167-173
22134498-4	2012	Based on the spectroscopic operando results, a concise mechanistic scheme of the selective catalytic reduction of nitric oxide by propene, triggered by a two-electron Co(II)/Co(0) redox couple, was developed.	co(0)	174-179	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	167-173
22223325-1	2012	The gas-phase ligand exchange reactions between Co(II) and Zn(II) complexes containing the acetylacetonate (acac), hexafluoroacetylacetonate (hfac), and trifluorotrimethylacetylacetonate (tftm) ligands were investigated using a triple quadrupole mass spectrometer.	tftm	188-192	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-65
24213228-2	2012	The treatment modality in our institutions before 2003 was surgical resection with wide surgical margin, however, meloxicam, which is a NSAID and a selective COX-2 inhibitor has been applied consecutively since 2003.	Meloxicam	114-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	158-163
22200308-1	2012	In the present work, a simple and rapid analytical method based on application of ionic liquids (ILs) for inorganic Co(II) species (iCo) microextraction in a variety of nutrient supplements was developed.	indole-3-carboxylic acid	132-135	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-122
22346827-2	2012	The Co(II) ion is six-coordinated in a distorted octa-hedral environment, binding to two water O atoms, to the ether O atom of the bicyclo-heptane unit, to two carboxyl-ate O atoms from two different carboxyl-ate groups of the same anion and to one carboxyl-ate O atom from a symmetry-related anion.	Water	89-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
22346827-2	2012	The Co(II) ion is six-coordinated in a distorted octa-hedral environment, binding to two water O atoms, to the ether O atom of the bicyclo-heptane unit, to two carboxyl-ate O atoms from two different carboxyl-ate groups of the same anion and to one carboxyl-ate O atom from a symmetry-related anion.	ether o	111-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
22346827-2	2012	The Co(II) ion is six-coordinated in a distorted octa-hedral environment, binding to two water O atoms, to the ether O atom of the bicyclo-heptane unit, to two carboxyl-ate O atoms from two different carboxyl-ate groups of the same anion and to one carboxyl-ate O atom from a symmetry-related anion.	bicyclo-heptane	131-146	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
22415556-3	2012	LaCoO(3), which stabilizes Co(III) species in the perovskite structure, exhibited the highest catalytic activity in the photocatalytic water oxidation compared with CoWO(4), Co(3)O(4) and La(0.7)Sr(0.3)CoO(3) which contain Co(II) or Co(IV) species in the matrices.	lacoo(3)	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	223-229
22415556-3	2012	LaCoO(3), which stabilizes Co(III) species in the perovskite structure, exhibited the highest catalytic activity in the photocatalytic water oxidation compared with CoWO(4), Co(3)O(4) and La(0.7)Sr(0.3)CoO(3) which contain Co(II) or Co(IV) species in the matrices.	coo(3)	2-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	223-229
22262921-11	2012	In conclusion, inhibition of tumor COX-2-dependent PGE(2) by celecoxib may reduce tumor progression.	Prostaglandins E	51-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40
22262921-11	2012	In conclusion, inhibition of tumor COX-2-dependent PGE(2) by celecoxib may reduce tumor progression.	Celecoxib	61-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40
22262921-12	2012	However, the coincident depression of vascular PGI(2), in a context of enhanced TXA(2) biosynthesis, may modulate the attendant angiogenesis, contributing to variability in the chemopreventive efficacy of COX-2 inhibitors such as celecoxib.	Epoprostenol	47-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	205-210
22499122-6	2012	Moreover, we have newly identified the two genes that are down-regulated in ESCC: monoamine oxidase A, an enzyme that catalyzes monoamines oxidation and 15-hydroxyprostaglandin dehydrogenase [NAD+], a prostaglandin-synthesizing enzyme that physiologically antagonizes COX-2.	NAD	192-196	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	268-273
22390933-1	2012	It is well-known that sphingosine-1-phosphate (S1P), the phospholipid content of HDL, binding to S1P receptors can raise COX-2 expression and PGI(2) release through p38MAPK/CREB pathway.	sphingosine 1-phosphate	22-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-126
22390933-1	2012	It is well-known that sphingosine-1-phosphate (S1P), the phospholipid content of HDL, binding to S1P receptors can raise COX-2 expression and PGI(2) release through p38MAPK/CREB pathway.	sphingosine 1-phosphate	47-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-126
22390933-1	2012	It is well-known that sphingosine-1-phosphate (S1P), the phospholipid content of HDL, binding to S1P receptors can raise COX-2 expression and PGI(2) release through p38MAPK/CREB pathway.	Phospholipids	57-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-126
22390933-6	2012	Consistently, the declines of p-p38MAPK, p-CREB, COX-2 and PGI(2) were also observed after incubation with LY294002 (25mumol/L; PI3K special inhibitor) or L-NAME (50mumol/L; eNOS special inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	107-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-54
22390933-7	2012	In addition, we demonstrated the increases of PGI(2) release, COX-2 expression and p38MAPK phosphorylation, when nitric oxide level was raised through the incubation of L-arginine (10 or 20nmol/L) in endothelial cells.	Arginine	169-179	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
22361134-3	2012	1-Benzoyl-3-[(4-trifluoromethylphenylimino)methyl]indole (20) emerged as the most potent (COX-1 IC(50) &gt;100 muM; COX-2 IC(50)=0.32 muM) and selective (SI &gt;312) COX-2 inhibitor.	1-benzoyl-3-[(4-trifluoromethylphenylimino)methyl]indole	0-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-121
22361134-3	2012	1-Benzoyl-3-[(4-trifluoromethylphenylimino)methyl]indole (20) emerged as the most potent (COX-1 IC(50) &gt;100 muM; COX-2 IC(50)=0.32 muM) and selective (SI &gt;312) COX-2 inhibitor.	1-benzoyl-3-[(4-trifluoromethylphenylimino)methyl]indole	0-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	166-171
22361134-5	2012	Molecular modeling studies employing compound 20 showed that the phenyl CF(3) substituent attached to the CN spacer is positioned near the secondary pocket of the COX-2 active site, the CN nitrogen atom is hydrogen bonded (N   NH=2.85 A) to the H90 residue, and the indole N-1 benzoyl is positioned in a hydrophobic pocket of the COX-2 active site near W387.	Nitrogen	189-197	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	163-168
22361134-5	2012	Molecular modeling studies employing compound 20 showed that the phenyl CF(3) substituent attached to the CN spacer is positioned near the secondary pocket of the COX-2 active site, the CN nitrogen atom is hydrogen bonded (N   NH=2.85 A) to the H90 residue, and the indole N-1 benzoyl is positioned in a hydrophobic pocket of the COX-2 active site near W387.	Hydrogen	206-214	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	163-168
22361134-5	2012	Molecular modeling studies employing compound 20 showed that the phenyl CF(3) substituent attached to the CN spacer is positioned near the secondary pocket of the COX-2 active site, the CN nitrogen atom is hydrogen bonded (N   NH=2.85 A) to the H90 residue, and the indole N-1 benzoyl is positioned in a hydrophobic pocket of the COX-2 active site near W387.	indole	266-272	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	163-168
22361134-5	2012	Molecular modeling studies employing compound 20 showed that the phenyl CF(3) substituent attached to the CN spacer is positioned near the secondary pocket of the COX-2 active site, the CN nitrogen atom is hydrogen bonded (N   NH=2.85 A) to the H90 residue, and the indole N-1 benzoyl is positioned in a hydrophobic pocket of the COX-2 active site near W387.	n-1 benzoyl	273-284	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	163-168
22252110-1	2012	A cubic cage complex assembled from twelve bis-bidentate ligands and eight Co(II) ions provides a cavity that selectively recognises and binds coumarin in MeCN solution.	coumarin	143-151	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-81
22252110-1	2012	A cubic cage complex assembled from twelve bis-bidentate ligands and eight Co(II) ions provides a cavity that selectively recognises and binds coumarin in MeCN solution.	acetonitrile	155-159	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-81
22299646-1	2012	Proton-coupled electron-transfer reduction of dioxygen (O(2)) to afford hydrogen peroxide (H(2)O(2)) was investigated by using ferrocene derivatives as reductants and saddle-distorted (alpha-octaphenylphthalocyaninato)cobalt(II) (Co(II)(Ph(8)Pc)) as a catalyst under acidic conditions.	Oxygen	46-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	230-236
22299646-1	2012	Proton-coupled electron-transfer reduction of dioxygen (O(2)) to afford hydrogen peroxide (H(2)O(2)) was investigated by using ferrocene derivatives as reductants and saddle-distorted (alpha-octaphenylphthalocyaninato)cobalt(II) (Co(II)(Ph(8)Pc)) as a catalyst under acidic conditions.	Oxygen	56-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	230-236
22299646-1	2012	Proton-coupled electron-transfer reduction of dioxygen (O(2)) to afford hydrogen peroxide (H(2)O(2)) was investigated by using ferrocene derivatives as reductants and saddle-distorted (alpha-octaphenylphthalocyaninato)cobalt(II) (Co(II)(Ph(8)Pc)) as a catalyst under acidic conditions.	Hydrogen Peroxide	72-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	230-236
22299646-1	2012	Proton-coupled electron-transfer reduction of dioxygen (O(2)) to afford hydrogen peroxide (H(2)O(2)) was investigated by using ferrocene derivatives as reductants and saddle-distorted (alpha-octaphenylphthalocyaninato)cobalt(II) (Co(II)(Ph(8)Pc)) as a catalyst under acidic conditions.	Hydrogen Peroxide	91-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	230-236
22299646-1	2012	Proton-coupled electron-transfer reduction of dioxygen (O(2)) to afford hydrogen peroxide (H(2)O(2)) was investigated by using ferrocene derivatives as reductants and saddle-distorted (alpha-octaphenylphthalocyaninato)cobalt(II) (Co(II)(Ph(8)Pc)) as a catalyst under acidic conditions.	alpha-octaphenylphthalocyaninato)cobalt(ii)	185-228	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	230-236
22299646-4	2012	The active species to react with O(2) in the catalytic reaction is switched from Co(II)(Ph(8)Pc) to protonated Co(I)(Ph(8)PcH), depending on the reducing ability of ferrocene derivatives employed.	Oxygen	33-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-87
22299646-4	2012	The active species to react with O(2) in the catalytic reaction is switched from Co(II)(Ph(8)Pc) to protonated Co(I)(Ph(8)PcH), depending on the reducing ability of ferrocene derivatives employed.	poly(ethylene oxide)-b-poly(alpha-cholesteryl carboxylate-epsilon-caprolactone) block copolymer	122-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-87
22299646-4	2012	The active species to react with O(2) in the catalytic reaction is switched from Co(II)(Ph(8)Pc) to protonated Co(I)(Ph(8)PcH), depending on the reducing ability of ferrocene derivatives employed.	ferrocene	165-174	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-87
22299646-5	2012	The protonation of Co(II)(Ph(8)Pc) inhibits the direct reduction of O(2); however, the proton-coupled electron transfer from Me(10)Fc to Co(II)(Ph(8)Pc) and the protonated [Co(II)(Ph(8)PcH)](+) occurs to produce Co(I)(Ph(8)PcH) and [Co(I)(Ph(8)PcH(2))](+), respectively, which react immediately with O(2).	Oxygen	68-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-25
22299646-5	2012	The protonation of Co(II)(Ph(8)Pc) inhibits the direct reduction of O(2); however, the proton-coupled electron transfer from Me(10)Fc to Co(II)(Ph(8)Pc) and the protonated [Co(II)(Ph(8)PcH)](+) occurs to produce Co(I)(Ph(8)PcH) and [Co(I)(Ph(8)PcH(2))](+), respectively, which react immediately with O(2).	Oxygen	68-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-143
22299646-5	2012	The protonation of Co(II)(Ph(8)Pc) inhibits the direct reduction of O(2); however, the proton-coupled electron transfer from Me(10)Fc to Co(II)(Ph(8)Pc) and the protonated [Co(II)(Ph(8)PcH)](+) occurs to produce Co(I)(Ph(8)PcH) and [Co(I)(Ph(8)PcH(2))](+), respectively, which react immediately with O(2).	Oxygen	68-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-143
22299646-5	2012	The protonation of Co(II)(Ph(8)Pc) inhibits the direct reduction of O(2); however, the proton-coupled electron transfer from Me(10)Fc to Co(II)(Ph(8)Pc) and the protonated [Co(II)(Ph(8)PcH)](+) occurs to produce Co(I)(Ph(8)PcH) and [Co(I)(Ph(8)PcH(2))](+), respectively, which react immediately with O(2).	pch)	185-189	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-25
22299646-5	2012	The protonation of Co(II)(Ph(8)Pc) inhibits the direct reduction of O(2); however, the proton-coupled electron transfer from Me(10)Fc to Co(II)(Ph(8)Pc) and the protonated [Co(II)(Ph(8)PcH)](+) occurs to produce Co(I)(Ph(8)PcH) and [Co(I)(Ph(8)PcH(2))](+), respectively, which react immediately with O(2).	pch)	185-189	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-143
22299646-5	2012	The protonation of Co(II)(Ph(8)Pc) inhibits the direct reduction of O(2); however, the proton-coupled electron transfer from Me(10)Fc to Co(II)(Ph(8)Pc) and the protonated [Co(II)(Ph(8)PcH)](+) occurs to produce Co(I)(Ph(8)PcH) and [Co(I)(Ph(8)PcH(2))](+), respectively, which react immediately with O(2).	pch)	185-189	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-143
22299646-5	2012	The protonation of Co(II)(Ph(8)Pc) inhibits the direct reduction of O(2); however, the proton-coupled electron transfer from Me(10)Fc to Co(II)(Ph(8)Pc) and the protonated [Co(II)(Ph(8)PcH)](+) occurs to produce Co(I)(Ph(8)PcH) and [Co(I)(Ph(8)PcH(2))](+), respectively, which react immediately with O(2).	poly(ethylene oxide)-b-poly(alpha-cholesteryl carboxylate-epsilon-caprolactone) block copolymer	185-188	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-25
22299646-5	2012	The protonation of Co(II)(Ph(8)Pc) inhibits the direct reduction of O(2); however, the proton-coupled electron transfer from Me(10)Fc to Co(II)(Ph(8)Pc) and the protonated [Co(II)(Ph(8)PcH)](+) occurs to produce Co(I)(Ph(8)PcH) and [Co(I)(Ph(8)PcH(2))](+), respectively, which react immediately with O(2).	poly(ethylene oxide)-b-poly(alpha-cholesteryl carboxylate-epsilon-caprolactone) block copolymer	185-188	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-143
22267479-7	2012	However, inhibition of prostaglandin D2 receptor by MK0524 or COX2 by NS398 did not alter the anti-inflammatory effects of NA observed in activated human monocytes.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	70-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-66
22179411-1	2012	Cyclooxygenase (COX)-2 and its products, including PGE2, are key inflammatory             mediators.	Dinoprostone	51-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-22
22179411-2	2012	In this study, we have assessed the pharmacological characteristics             of BAI, a 3-aminoindazole derivative and a novel cyclin-dependent kinase (CDK)             inhibitor, for regulation of COX-2 expression induced by interleukin (IL)-1beta in             A549 human airway cells.	1H-Indazol-3-amine	90-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	200-205
22179411-7	2012	Interestingly, additional cell culture experiments showed the             ability of BAI to repress the PMA-induced COX-2 expression in A549 cells and serum-dependent             COX-2 expression in NCI-H292 cells, a human laryngeal cell line.	Tetradecanoylphorbol Acetate	104-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-121
21655952-1	2012	Cyclooxygenase two (COX-2) is an important enzyme metabolizing arachidonic acid.	Arachidonic Acid	63-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-25
22296602-1	2012	The use of the recently prepared polynitrile ligand tcnopr3OH(-) ([(NC)(2)CC(OCH(2)CH(2)CH(2)OH)C(CN)(2)](-)) with different salts of Fe(II), Co(II), and Ni(II) has led to a very rare example of linkage isomerism in a coordination chain.	polynitrile	33-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	142-147
22296602-1	2012	The use of the recently prepared polynitrile ligand tcnopr3OH(-) ([(NC)(2)CC(OCH(2)CH(2)CH(2)OH)C(CN)(2)](-)) with different salts of Fe(II), Co(II), and Ni(II) has led to a very rare example of linkage isomerism in a coordination chain.	tcnopr3oh	52-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	142-147
22240735-1	2012	Examination of the aqueous electrochemistry of a Co(II) complex bearing a pentadentate ligand suggests that the catalytic current corresponding to water oxidation is molecular in origin, and does not emanate exclusively from Co-oxide phases formed in situ.	pentadentate	74-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-55
22240735-1	2012	Examination of the aqueous electrochemistry of a Co(II) complex bearing a pentadentate ligand suggests that the catalytic current corresponding to water oxidation is molecular in origin, and does not emanate exclusively from Co-oxide phases formed in situ.	Water	147-152	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-55
22240735-1	2012	Examination of the aqueous electrochemistry of a Co(II) complex bearing a pentadentate ligand suggests that the catalytic current corresponding to water oxidation is molecular in origin, and does not emanate exclusively from Co-oxide phases formed in situ.	co-oxide	225-233	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-55
22059536-1	2012	Triply switchable [Co(II)(dpzca)(2)] shows an abrupt, reversible, and hysteretic spin crossover (T(1/2)  = 168 K, T(1/2)  = 179 K, and DeltaT(1/2) = 11 K) between the high-spin (HS) and low-spin (LS) states of cobalt(II), both of which have been structurally characterized.	leucylserine	196-198	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-24
22059536-1	2012	Triply switchable [Co(II)(dpzca)(2)] shows an abrupt, reversible, and hysteretic spin crossover (T(1/2)  = 168 K, T(1/2)  = 179 K, and DeltaT(1/2) = 11 K) between the high-spin (HS) and low-spin (LS) states of cobalt(II), both of which have been structurally characterized.	Cobalt(2+)	210-220	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-24
22223325-1	2012	The gas-phase ligand exchange reactions between Co(II) and Zn(II) complexes containing the acetylacetonate (acac), hexafluoroacetylacetonate (hfac), and trifluorotrimethylacetylacetonate (tftm) ligands were investigated using a triple quadrupole mass spectrometer.	acetyl acetonate	91-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-65
22223325-1	2012	The gas-phase ligand exchange reactions between Co(II) and Zn(II) complexes containing the acetylacetonate (acac), hexafluoroacetylacetonate (hfac), and trifluorotrimethylacetylacetonate (tftm) ligands were investigated using a triple quadrupole mass spectrometer.	acetyl acetonate	108-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-65
22223325-1	2012	The gas-phase ligand exchange reactions between Co(II) and Zn(II) complexes containing the acetylacetonate (acac), hexafluoroacetylacetonate (hfac), and trifluorotrimethylacetylacetonate (tftm) ligands were investigated using a triple quadrupole mass spectrometer.	hexafluoroacetylacetonate	115-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-65
22223325-1	2012	The gas-phase ligand exchange reactions between Co(II) and Zn(II) complexes containing the acetylacetonate (acac), hexafluoroacetylacetonate (hfac), and trifluorotrimethylacetylacetonate (tftm) ligands were investigated using a triple quadrupole mass spectrometer.	hexafluoroacetylacetonate	142-146	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-65
22223325-1	2012	The gas-phase ligand exchange reactions between Co(II) and Zn(II) complexes containing the acetylacetonate (acac), hexafluoroacetylacetonate (hfac), and trifluorotrimethylacetylacetonate (tftm) ligands were investigated using a triple quadrupole mass spectrometer.	trifluorotrimethylacetylacetonate	153-186	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-65
22360191-9	2012	For divalent Cu(II) and Co(II) the adsorption energies at cations in chabazite are much lower than the metal-molecule binding energies in the free carbonyls or nitrosyls, especially for the most stable cation location in a six-membered ring of the chabazite structure.	chabazite	69-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-30
22360191-9	2012	For divalent Cu(II) and Co(II) the adsorption energies at cations in chabazite are much lower than the metal-molecule binding energies in the free carbonyls or nitrosyls, especially for the most stable cation location in a six-membered ring of the chabazite structure.	chabazite	248-257	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-30
22360191-13	2012	For NO adsorbed in Cu(II)- and Co(II)-chabazite gradient-corrected functionals produce the best agreement with experiment for cations located in a six-membered ring.	chabazite	38-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-37
21989533-8	2012	Variable temperature magnetic measurements show that [Fe(III)(pypzca)(2)]ClO(4) undergoes a gradual spin crossover from partially high spin at 298 K (3.00 BM) to fully low spin at 2 K (1.96 BM), and that [Co(II)(pypzca)(2)] remains high spin from 298 to 4 K. All of the complexes are weakly coloured, other than [Fe(II)(pypzca)(2)] which is dark purple and absorbs strongly in the visible region.	fe(iii)(	54-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	205-210
21989533-8	2012	Variable temperature magnetic measurements show that [Fe(III)(pypzca)(2)]ClO(4) undergoes a gradual spin crossover from partially high spin at 298 K (3.00 BM) to fully low spin at 2 K (1.96 BM), and that [Co(II)(pypzca)(2)] remains high spin from 298 to 4 K. All of the complexes are weakly coloured, other than [Fe(II)(pypzca)(2)] which is dark purple and absorbs strongly in the visible region.	)(2)]clo(4)	68-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	205-210
22260398-0	2012	Reduction of terphenyl Co(II) halide derivatives in the presence of arenes: insertion of Co(I) into a C-F bond.	arenes	68-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-29
22225915-0	2012	Design, synthesis, biological evaluation, and comparative Cox1 and Cox2 docking of p-substituted benzylidenamino phenyl esters of ibuprofenic and mefenamic acids.	p-substituted benzylidenamino phenyl esters	83-126	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-71
22225915-0	2012	Design, synthesis, biological evaluation, and comparative Cox1 and Cox2 docking of p-substituted benzylidenamino phenyl esters of ibuprofenic and mefenamic acids.	ibuprofenic	130-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-71
22225915-0	2012	Design, synthesis, biological evaluation, and comparative Cox1 and Cox2 docking of p-substituted benzylidenamino phenyl esters of ibuprofenic and mefenamic acids.	Mefenamic Acid	146-161	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-71
22225915-8	2012	Additionally, a comparative AutoDock study into Cox 1 and Cox2 has been done involving both of rigid and flexible docking for potential selectivity of our compounds within different Cox enzymes and to find out the binding orientation of these novel esters into their binding site.	Esters	249-255	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-62
21983014-1	2012	Dimethylcelecoxib, a non-COX-2 inhibiting derivative of celecoxib, inhibits PGE(2) synthesis by transcriptional inhibition of mPGES-1.	2,5-dimethylcelecoxib	0-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-30
21983014-1	2012	Dimethylcelecoxib, a non-COX-2 inhibiting derivative of celecoxib, inhibits PGE(2) synthesis by transcriptional inhibition of mPGES-1.	Celecoxib	8-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-30
22166248-2	2012	Most of the COX-2 tumor-inducing effects are believed to be mediated through overproduction of prostaglandin E(2) (PGE(2)), which can be measured using a urinary metabolite of PGE(2), PGE-M. Urinary PGE-M was assessed in a case-control study of colorectal adenoma.	Dinoprostone	95-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-17
22166248-2	2012	Most of the COX-2 tumor-inducing effects are believed to be mediated through overproduction of prostaglandin E(2) (PGE(2)), which can be measured using a urinary metabolite of PGE(2), PGE-M. Urinary PGE-M was assessed in a case-control study of colorectal adenoma.	Prostaglandins E	115-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-17
22166248-2	2012	Most of the COX-2 tumor-inducing effects are believed to be mediated through overproduction of prostaglandin E(2) (PGE(2)), which can be measured using a urinary metabolite of PGE(2), PGE-M. Urinary PGE-M was assessed in a case-control study of colorectal adenoma.	Prostaglandins E	176-179	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-17
22166248-2	2012	Most of the COX-2 tumor-inducing effects are believed to be mediated through overproduction of prostaglandin E(2) (PGE(2)), which can be measured using a urinary metabolite of PGE(2), PGE-M. Urinary PGE-M was assessed in a case-control study of colorectal adenoma.	Prostaglandins E	176-179	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-17
22166248-2	2012	Most of the COX-2 tumor-inducing effects are believed to be mediated through overproduction of prostaglandin E(2) (PGE(2)), which can be measured using a urinary metabolite of PGE(2), PGE-M. Urinary PGE-M was assessed in a case-control study of colorectal adenoma.	Prostaglandins E	176-179	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-17
22376259-1	2012	Single nucleotide polymorphisms (SNPs) in the promoter and untranslated region of cyclooxygenase (COX)-2, an inducible enzyme responsible for the synthesis of prostaglandins, have been reported to modulate the risk for many human cancers.	Prostaglandins	159-173	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-104
22197135-0	2012	A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions.	viscolin	23-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-105
22197135-3	2012	Viscolin blocked the expression of iNOS and COX-2, and it also inhibited the ERK for the activation of NF-kappaB in LPS-stimulated RAW 264.7 macrophages.	viscolin	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-49
22197135-4	2012	Western blotting and immunohistochemical analysis revealed that viscolin decreased Carr-induced iNOS and COX-2 expressions.	viscolin	64-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-110
22207007-2	2012	The deprotonated tolfenamato ligands are coordinated to Co(II) ion through carboxylato oxygen atoms.	Oxygen	87-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-62
21699462-6	2012	The increase in total COX activity was accompanied with enhanced activity of COX-2, differentiated by using the COX-1 isoform-specific inhibitor SC-560.	SC 560	145-151	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-82
22309084-2	2012	Using mesangial cells as a cellular model of inflammation we have observed that 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)) exerts a biphasic effect on cell activation by cytokines, with nanomolar concentrations eliciting an amplification of nitric oxide (NO) production and iNOS and COX-2 levels, and concentrations of 5 muM and higher inhibiting proinflammatory gene expression.	15-deoxy-delta(12,14)-prostaglandin j	80-117	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	294-299
22178666-2	2012	The deprotonated naproxen acts as monodentate ligand coordinated to Co(II) ion through a carboxylato oxygen.	Naproxen	17-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-74
22209282-9	2012	N-oleoyl-phytosphingosine increased the expression of MMP-1 and IL-6 mRNA, while decreasing the expression of COX-2 mRNA.	ceramide 3	0-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-115
22178666-2	2012	The deprotonated naproxen acts as monodentate ligand coordinated to Co(II) ion through a carboxylato oxygen.	Oxygen	101-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-74
22412812-4	2012	PGE2 production was blocked with greater efficacy (IC50 values of 7.5, 0.89, and 0.63 muM, respectively), possibly due to inhibition of cyclooxygenases in addition to the expression of COX-2.	Dinoprostone	0-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	185-190
22002318-1	2012	Rofecoxib is a specific COX-2 inhibitor able to exert antiproliferative activity against colorectal cancer cells.	rofecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
22002318-7	2012	NO-rofe exerted a significant antiproliferative activity on COX-2 positive HT-29 human colon cancer cells, being less effective on the COX-2 negative SW-480 human colon cancer cell line.	rofe	3-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-65
22002318-8	2012	In particular, the rofecoxib analogue retained similar potencies with respect to COX-2 inhibition but was much more active than rofecoxib in inhibiting the growth of human colon cancer cells in vitro.	rofecoxib	19-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-86
22179398-1	2012	Postsynthetic metal ion exchange in a benzotriazolate-based MFU-4l(arge) framework leads to a Co(II)-containing framework with open metal sites showing reversible gas-phase oxidation properties.	Metals	14-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-99
22137746-5	2012	Acryloyl hydrazine (AH) has been shown to behave as a bidentate ligand via its nitrogen (NH(2) of hydrazine group) and C-O/C=O (acryloyl group) in polymer complexes, all of which exhibit supramolecular architectures assembled through weak interaction including hydrogen bonding and pi-pi stacking .The magnetic and spectral data indicate a square planar geometry for Cu(2+) complexes and an octahedral geometry for Co(II) and UO(2)(II).	acryloyl hydrazine	0-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	415-421
22137746-5	2012	Acryloyl hydrazine (AH) has been shown to behave as a bidentate ligand via its nitrogen (NH(2) of hydrazine group) and C-O/C=O (acryloyl group) in polymer complexes, all of which exhibit supramolecular architectures assembled through weak interaction including hydrogen bonding and pi-pi stacking .The magnetic and spectral data indicate a square planar geometry for Cu(2+) complexes and an octahedral geometry for Co(II) and UO(2)(II).	ah	20-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	415-421
22137746-5	2012	Acryloyl hydrazine (AH) has been shown to behave as a bidentate ligand via its nitrogen (NH(2) of hydrazine group) and C-O/C=O (acryloyl group) in polymer complexes, all of which exhibit supramolecular architectures assembled through weak interaction including hydrogen bonding and pi-pi stacking .The magnetic and spectral data indicate a square planar geometry for Cu(2+) complexes and an octahedral geometry for Co(II) and UO(2)(II).	hydrazine	9-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	415-421
22081376-0	2012	COX-2 and survivin reduction may play a role in berberine-induced apoptosis in human ductal breast epithelial tumor cell line.	Berberine	48-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
22081376-2	2012	It has been illustrated that the antiinflammatory effect is mediated by suppressing the nuclear factor-kappa B (NF-kappaB) that activates expression of some antiinflammatory and antiapoptotic proteins including cyclooxygenase-2(COX-2), inducible nitric oxide synthase (iNOS) and survivin; therefore, berberine may induce apoptosis by reducing antiinflammatory and antiapoptotic agents, which suggest the relationship between antiinflammatory and apoptosis pathways.	Berberine	300-309	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	228-233
22081376-5	2012	The level of COX-2, iNOS and survivin proteins decreased in berberine-treated cells; however, treatment of the cells with aspirin and aminoguanidine (AG), COX-2 and iNOS inhibitors, respectively, showed that despite the cell growth-reducing effect of aspirin, AG did not have a significant effect on cell viability.	Berberine	60-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
22081376-5	2012	The level of COX-2, iNOS and survivin proteins decreased in berberine-treated cells; however, treatment of the cells with aspirin and aminoguanidine (AG), COX-2 and iNOS inhibitors, respectively, showed that despite the cell growth-reducing effect of aspirin, AG did not have a significant effect on cell viability.	Berberine	60-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	155-160
22081376-6	2012	On the other hand, with the attention to reduction in survivin protein level in berberine-treated cells, the results suggest that the apoptotic effect of berberine may be mediated by reduction in both of the COX-2 and survivin in T47D cell line, while the iNOS does not play any effective role in berberine-induced apoptosis.	Berberine	80-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	208-213
22081376-6	2012	On the other hand, with the attention to reduction in survivin protein level in berberine-treated cells, the results suggest that the apoptotic effect of berberine may be mediated by reduction in both of the COX-2 and survivin in T47D cell line, while the iNOS does not play any effective role in berberine-induced apoptosis.	Berberine	154-163	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	208-213
22081376-6	2012	On the other hand, with the attention to reduction in survivin protein level in berberine-treated cells, the results suggest that the apoptotic effect of berberine may be mediated by reduction in both of the COX-2 and survivin in T47D cell line, while the iNOS does not play any effective role in berberine-induced apoptosis.	Berberine	154-163	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	208-213
22015639-10	2012	H(2)S-induced expression of IL-6, IL-8 and COX-2 was completely blocked by specific inhibitors of p38 and ERK1/2 MAPK and NF-kappaB.	Hydrogen Sulfide	0-5	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
22179398-1	2012	Postsynthetic metal ion exchange in a benzotriazolate-based MFU-4l(arge) framework leads to a Co(II)-containing framework with open metal sites showing reversible gas-phase oxidation properties.	benzotriazolate	38-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-99
22179398-1	2012	Postsynthetic metal ion exchange in a benzotriazolate-based MFU-4l(arge) framework leads to a Co(II)-containing framework with open metal sites showing reversible gas-phase oxidation properties.	arge	67-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-99
22179398-1	2012	Postsynthetic metal ion exchange in a benzotriazolate-based MFU-4l(arge) framework leads to a Co(II)-containing framework with open metal sites showing reversible gas-phase oxidation properties.	Metals	132-137	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-99
22175783-1	2012	The first example of an O(2) adduct of an active Co-substituted oxygenase has been observed in the extradiol ring cleavage of the electron-poor substrate 4-nitrocatechol (4NC) by Co(II)-homoprotocatechuate 2,3-dioxygenase (Co-HPCD).	Superoxides	24-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	179-185
22148253-2	2012	In this regard, NSAID ester intermediates were potent and selective COX-2 inhibitors in vitro, showed equipotent anti-inflammatory activity compared to the corresponding parent NSAID, but showed a markedly reduced gastric toxicity when administered orally.	Esters	22-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-73
22175783-1	2012	The first example of an O(2) adduct of an active Co-substituted oxygenase has been observed in the extradiol ring cleavage of the electron-poor substrate 4-nitrocatechol (4NC) by Co(II)-homoprotocatechuate 2,3-dioxygenase (Co-HPCD).	4-nitrocatechol	154-169	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	179-185
22175783-2	2012	Upon O(2) binding to the high-spin Co(II) (S = (3)/(2)) enzyme-substrate complex, an S = (1)/(2) EPR signal exhibiting (59)Co hyperfine splitting (A = 24 G) typical of a low-spin Co(III)-superoxide complex was observed.	Superoxides	5-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-41
22175783-2	2012	Upon O(2) binding to the high-spin Co(II) (S = (3)/(2)) enzyme-substrate complex, an S = (1)/(2) EPR signal exhibiting (59)Co hyperfine splitting (A = 24 G) typical of a low-spin Co(III)-superoxide complex was observed.	co(iii)	179-186	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-41
22175783-2	2012	Upon O(2) binding to the high-spin Co(II) (S = (3)/(2)) enzyme-substrate complex, an S = (1)/(2) EPR signal exhibiting (59)Co hyperfine splitting (A = 24 G) typical of a low-spin Co(III)-superoxide complex was observed.	Superoxides	187-197	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-41
22220944-0	2012	2-Aminoisobutyric acid in Co(II) and Co(II)/Ln(III) chemistry: homometallic and heterometallic clusters.	2-aminoisobutyric acid	0-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-32
22220944-0	2012	2-Aminoisobutyric acid in Co(II) and Co(II)/Ln(III) chemistry: homometallic and heterometallic clusters.	2-aminoisobutyric acid	0-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-43
22220944-3	2012	Complexes 3-13 can all be regarded as metallo-cryptand encapsulated lanthanides in which the central lanthanide ion is captivated within a [Co(II)(6)] trigonal prism.	metallo-cryptand	38-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-146
22220944-3	2012	Complexes 3-13 can all be regarded as metallo-cryptand encapsulated lanthanides in which the central lanthanide ion is captivated within a [Co(II)(6)] trigonal prism.	Lanthanoid Series Elements	68-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-146
22220944-3	2012	Complexes 3-13 can all be regarded as metallo-cryptand encapsulated lanthanides in which the central lanthanide ion is captivated within a [Co(II)(6)] trigonal prism.	Lanthanoid Series Elements	68-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-146
22222039-0	2012	Synthesis, pharmacological evaluation and docking studies of N-(benzo[d]thiazol-2-yl)-2-(piperazin-1-yl)acetamide analogs as COX-2 inhibitors.	n-(benzo[d]thiazol-2-yl)-2-(piperazin-1-yl)acetamide	61-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-130
22222039-7	2012	In silico study reveal the binding interactions of N-(benzo[d]thiazol-2-yl)-2-(piperazin-1-yl)acetamide analogs with COX-2 protein and is in agreement with the in vivo anti-inflammatory activity.	n-(benzo[d]thiazol-2-yl)-2-(piperazin-1-yl)acetamide	51-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-122
22265488-0	2012	Voltammetric determination of cysteine using carbon paste electrode modified with Co(II)-Y zeolite.	Cysteine	30-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-88
22265488-2	2012	The electrode comprises a Co(II)-exchanged zeolite Y as modifier in carbon paste matrix.	Carbon	68-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-31
22265488-3	2012	First, the electrochemical behavior of Co(II) in modified carbon paste electrode was studied.	Carbon	58-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-45
22103778-9	2012	CONCLUSION: The combination of a COX-2 inhibitor and dexamethasone results in better pain relief 24 h after surgery in patients undergoing outpatient ACL surgery, compared to COX-2 inhibitor alone or dexamethasone alone.	Dexamethasone	53-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	175-180
22214188-8	2012	In contrast, the mTOR inhibitor rapamycin enhanced both COX-2 and mPGES-1 immunoreactivity and the release of PGE2 and PGD2.	Sirolimus	32-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-61
22214188-9	2012	Interestingly, NVP-BEZ235, a dual PI3K/mTOR inhibitor, enhanced COX-2 and reduced mPGES-1 immunoreactivity, albeit PGE2 and PGD2 levels were enhanced in LPS-stimulated microglia.	dactolisib	19-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-69
22214188-11	2012	CONCLUSION: Taken together, we demonstrate that blockade of mTOR and/or PI3K/Akt enhances prostanoid production and that PI3K/Akt, GSK-3 and mTOR differently regulate the expression of mPGES-1 and COX-2 in activated primary microglia.	Prostaglandins	90-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	197-202
22103778-9	2012	CONCLUSION: The combination of a COX-2 inhibitor and dexamethasone results in better pain relief 24 h after surgery in patients undergoing outpatient ACL surgery, compared to COX-2 inhibitor alone or dexamethasone alone.	Dexamethasone	200-213	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-38
23232244-2	2012	The ATPS-MSFA method was applied for the determination of cobalt, based on the reaction between Co(II) and KSCN, which produces a metallic complex that spontaneously partitions to the top phase of the ATPS composed of poly(ethylene oxide), ammonium sulfate and water.	Adenosine Triphosphate	4-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-111
22693688-14	2012	Vanadium pentoxide causes expression of COX-2 and the release of proinflammatory cytokines in a human lung fibroblast model.	vanadium pentoxide	0-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
22259365-1	2012	In the title compound, [Co(C(5)H(4)NO(3))(2)(H(2)O)(2)] 2H(2)O, the coordination polyhedron around the six-coordinate Co(II) ion is formed by two equatorial 5-methyl-isoxazole-3-carboxyl-ate ligands in an N,O(3)-bidentate fashion through the isoxazole N atom and a carboxyl-ate O atom, and by two axial water ligands.	co(c(5)h(4)no(3))	24-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-124
22259365-1	2012	In the title compound, [Co(C(5)H(4)NO(3))(2)(H(2)O)(2)] 2H(2)O, the coordination polyhedron around the six-coordinate Co(II) ion is formed by two equatorial 5-methyl-isoxazole-3-carboxyl-ate ligands in an N,O(3)-bidentate fashion through the isoxazole N atom and a carboxyl-ate O atom, and by two axial water ligands.	h(2)o)(2)] 2h(2)o	45-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-124
22259365-1	2012	In the title compound, [Co(C(5)H(4)NO(3))(2)(H(2)O)(2)] 2H(2)O, the coordination polyhedron around the six-coordinate Co(II) ion is formed by two equatorial 5-methyl-isoxazole-3-carboxyl-ate ligands in an N,O(3)-bidentate fashion through the isoxazole N atom and a carboxyl-ate O atom, and by two axial water ligands.	5-Methylisoxazole	157-175	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-124
22259365-1	2012	In the title compound, [Co(C(5)H(4)NO(3))(2)(H(2)O)(2)] 2H(2)O, the coordination polyhedron around the six-coordinate Co(II) ion is formed by two equatorial 5-methyl-isoxazole-3-carboxyl-ate ligands in an N,O(3)-bidentate fashion through the isoxazole N atom and a carboxyl-ate O atom, and by two axial water ligands.	punky blue	205-211	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-124
22259365-1	2012	In the title compound, [Co(C(5)H(4)NO(3))(2)(H(2)O)(2)] 2H(2)O, the coordination polyhedron around the six-coordinate Co(II) ion is formed by two equatorial 5-methyl-isoxazole-3-carboxyl-ate ligands in an N,O(3)-bidentate fashion through the isoxazole N atom and a carboxyl-ate O atom, and by two axial water ligands.	Water	303-308	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-124
23232244-2	2012	The ATPS-MSFA method was applied for the determination of cobalt, based on the reaction between Co(II) and KSCN, which produces a metallic complex that spontaneously partitions to the top phase of the ATPS composed of poly(ethylene oxide), ammonium sulfate and water.	msfa	9-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-111
23232244-2	2012	The ATPS-MSFA method was applied for the determination of cobalt, based on the reaction between Co(II) and KSCN, which produces a metallic complex that spontaneously partitions to the top phase of the ATPS composed of poly(ethylene oxide), ammonium sulfate and water.	Cobalt	58-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-111
23232244-2	2012	The ATPS-MSFA method was applied for the determination of cobalt, based on the reaction between Co(II) and KSCN, which produces a metallic complex that spontaneously partitions to the top phase of the ATPS composed of poly(ethylene oxide), ammonium sulfate and water.	Adenosine Triphosphate	201-205	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-111
23232244-2	2012	The ATPS-MSFA method was applied for the determination of cobalt, based on the reaction between Co(II) and KSCN, which produces a metallic complex that spontaneously partitions to the top phase of the ATPS composed of poly(ethylene oxide), ammonium sulfate and water.	poly	218-222	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-111
23232244-2	2012	The ATPS-MSFA method was applied for the determination of cobalt, based on the reaction between Co(II) and KSCN, which produces a metallic complex that spontaneously partitions to the top phase of the ATPS composed of poly(ethylene oxide), ammonium sulfate and water.	Ethylene Oxide	223-237	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-111
23232244-2	2012	The ATPS-MSFA method was applied for the determination of cobalt, based on the reaction between Co(II) and KSCN, which produces a metallic complex that spontaneously partitions to the top phase of the ATPS composed of poly(ethylene oxide), ammonium sulfate and water.	Ammonium Sulfate	240-256	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-111
23232244-2	2012	The ATPS-MSFA method was applied for the determination of cobalt, based on the reaction between Co(II) and KSCN, which produces a metallic complex that spontaneously partitions to the top phase of the ATPS composed of poly(ethylene oxide), ammonium sulfate and water.	Water	261-266	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-111
23480764-3	2012	Thus, the aim of this study was to examine the effects of two anti-inflammatory agents, meloxicam, a selective COX-2 inhibitor, and xanthohumol, a natural plant extract, on PGE2 production and migration ability of human CCA cell lines.	Meloxicam	88-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	111-116
22400016-1	2012	Metal complexes of (Z)-2-(pyrrolidin-2-ylidene)hydrazinecarbothioamide (L) with Cu(II), Co(II), and Ni(II) chlorides were tested against selected types of fungi and were found to have significant antifungal activities.	Metals	0-5	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-93
22400016-1	2012	Metal complexes of (Z)-2-(pyrrolidin-2-ylidene)hydrazinecarbothioamide (L) with Cu(II), Co(II), and Ni(II) chlorides were tested against selected types of fungi and were found to have significant antifungal activities.	(z)-2-(pyrrolidin-2-ylidene)hydrazinecarbothioamide	19-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-93
22100241-3	2012	Furthermore, effects of initial pH, ionic strength, temperature, contact time and initial metal ion concentration on the biosorption capacities of Cu(II) and Co(II) ions onto the copolymers were studied using batch sorption technique.	copolymers	179-189	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	158-164
22611346-0	2012	Binuclear Cu(II) and Co(II) Complexes of Tridentate Heterocyclic Shiff Base Derived from Salicylaldehyde with 4-Aminoantipyrine.	salicylaldehyde	89-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-27
22611346-0	2012	Binuclear Cu(II) and Co(II) Complexes of Tridentate Heterocyclic Shiff Base Derived from Salicylaldehyde with 4-Aminoantipyrine.	Ampyrone	110-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-27
22611346-1	2012	New binuclear Co(II) and Co(II) complexes of ONO tridentate heterocyclic Schiff base derived from 4-aminoantipyrine with salicylaldehyde have been synthesized and characterized on the bases of elemental analysis, UV-Vis., FT-IR, and also by aid of molar conductivity measurements, magnetic measurements, and melting points.	Schiff Bases	73-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-20
22611346-1	2012	New binuclear Co(II) and Co(II) complexes of ONO tridentate heterocyclic Schiff base derived from 4-aminoantipyrine with salicylaldehyde have been synthesized and characterized on the bases of elemental analysis, UV-Vis., FT-IR, and also by aid of molar conductivity measurements, magnetic measurements, and melting points.	Schiff Bases	73-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-31
22611346-1	2012	New binuclear Co(II) and Co(II) complexes of ONO tridentate heterocyclic Schiff base derived from 4-aminoantipyrine with salicylaldehyde have been synthesized and characterized on the bases of elemental analysis, UV-Vis., FT-IR, and also by aid of molar conductivity measurements, magnetic measurements, and melting points.	Ampyrone	98-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-20
22611346-1	2012	New binuclear Co(II) and Co(II) complexes of ONO tridentate heterocyclic Schiff base derived from 4-aminoantipyrine with salicylaldehyde have been synthesized and characterized on the bases of elemental analysis, UV-Vis., FT-IR, and also by aid of molar conductivity measurements, magnetic measurements, and melting points.	Ampyrone	98-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-31
22611346-1	2012	New binuclear Co(II) and Co(II) complexes of ONO tridentate heterocyclic Schiff base derived from 4-aminoantipyrine with salicylaldehyde have been synthesized and characterized on the bases of elemental analysis, UV-Vis., FT-IR, and also by aid of molar conductivity measurements, magnetic measurements, and melting points.	salicylaldehyde	121-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-20
22611346-1	2012	New binuclear Co(II) and Co(II) complexes of ONO tridentate heterocyclic Schiff base derived from 4-aminoantipyrine with salicylaldehyde have been synthesized and characterized on the bases of elemental analysis, UV-Vis., FT-IR, and also by aid of molar conductivity measurements, magnetic measurements, and melting points.	salicylaldehyde	121-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-31
22611346-2	2012	It has been found that the Schiff bases with Cu(II) or Co(II) ion forming binuclear complexes on (1 : 1) "metal : ligand" stoichiometry.	Schiff Bases	27-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-61
22611346-2	2012	It has been found that the Schiff bases with Cu(II) or Co(II) ion forming binuclear complexes on (1 : 1) "metal : ligand" stoichiometry.	Metals	106-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-61
22100241-4	2012	It was found that the copolymers exhibited excellent biosorption characteristics for Cu(II) and Co(II) ions.	copolymers	22-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-102
22135046-2	2012	COX-2-derived prostaglandin E(2) (PGE(2)) has been linked to both inflammation and carcinogenesis.	Dinoprostone	14-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
22891999-2	2012	In these studies, we have (a) identified the diverse eicosanoid pathways that are activated in human chondrocytes of normal and OA cartilage, (b) delineated the modulation of eicosanoids in the presence of NSAIDS and selective COX-2 inhibitors, and (c) characterized eicosanoid products and various transcripts modulated by various inhibitors of eicosanoids in human OA cartilage by gene expression arrays.	Eicosanoids	175-186	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	227-232
22891999-2	2012	In these studies, we have (a) identified the diverse eicosanoid pathways that are activated in human chondrocytes of normal and OA cartilage, (b) delineated the modulation of eicosanoids in the presence of NSAIDS and selective COX-2 inhibitors, and (c) characterized eicosanoid products and various transcripts modulated by various inhibitors of eicosanoids in human OA cartilage by gene expression arrays.	Eicosanoids	175-185	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	227-232
22891999-14	2012	Furthermore, celecoxib, a selective COX-2 inhibitor, regulated numerous genes in cartilage, which are linked to the NFkB and AP-1 pathways at the mRNA level.	Celecoxib	13-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-41
22135046-2	2012	COX-2-derived prostaglandin E(2) (PGE(2)) has been linked to both inflammation and carcinogenesis.	Dinoprostone	34-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
22135046-8	2012	Finally, levels of cervical COX-2 correlated with urinary PGE-M levels (P = 0.005).	Prostaglandins E	58-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
22570544-1	2012	Ophthalmic bromfenac sodium sesquihydrate is a topically applied selective cyclooxygenase (COX)-2 inhibitor.	bromfenac	11-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-97
22036551-0	2012	Peroxymonosulfate-Co(II) oxidation system for the removal of the non-ionic surfactant Brij 35 from aqueous solution.	peroxymonosulfate	0-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-24
22036551-1	2012	The non-ionic surfactant Brij 35 was effectively removed from concentrated aqueous solution by the peroxymonosulfate/Co(II) system, using oxone (2KHSO(5) KHSO(4) K(2)SO(4)) as a source of peroxymonosulfate.	potassium peroxymonosulfuric acid	138-143	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-123
22570544-2	2012	It is similar to amfenac, except for a bromine atom at the C(4) of the benzoyl ring position, which markedly affects its in vitro and in vivo potency, extends the duration of anti-inflammatory activity, and enhances its inhibitory effect on COX-2 absorption across the cornea and penetration into ocular tissues.	amfenac	17-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	241-246
22570544-2	2012	It is similar to amfenac, except for a bromine atom at the C(4) of the benzoyl ring position, which markedly affects its in vitro and in vivo potency, extends the duration of anti-inflammatory activity, and enhances its inhibitory effect on COX-2 absorption across the cornea and penetration into ocular tissues.	Bromine	39-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	241-246
22518279-6	2012	Recent evidence supports the involvement of HO-1 in the antioxidant and antiinflammatory effect of cyclooxygenase(COX)-2-dependent prostacyclin in the vasculature.	Epoprostenol	131-143	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-120
22300072-3	2012	All these events are controlled by the cytokines and growth factors, GI hormones including gastrin, CCK, and orexigenic peptides such as ghrelin, orexin-A and obestatin as well as Cox2 generated prostaglandins.	Prostaglandins	195-209	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	180-184
22523472-0	2012	Resveratrol Targeting of Carcinogen-Induced Brain Endothelial Cell Inflammation Biomarkers MMP-9 and COX-2 is Sirt1-Independent.	Resveratrol	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-106
22523472-7	2012	HBMEC were treated with a combination of resveratrol and phorbol 12-myristate 13-acetate (PMA), a carcinogen known to increase MMP-9 and COX-2 through NF-kappaB.	Resveratrol	41-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-142
22523472-7	2012	HBMEC were treated with a combination of resveratrol and phorbol 12-myristate 13-acetate (PMA), a carcinogen known to increase MMP-9 and COX-2 through NF-kappaB.	Tetradecanoylphorbol Acetate	57-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-142
22523472-7	2012	HBMEC were treated with a combination of resveratrol and phorbol 12-myristate 13-acetate (PMA), a carcinogen known to increase MMP-9 and COX-2 through NF-kappaB.	Tetradecanoylphorbol Acetate	90-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-142
22523472-8	2012	We found that resveratrol efficiently reversed the PMA-induced MMP-9 secretion and COX-2 expression.	Resveratrol	14-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
22523472-8	2012	We found that resveratrol efficiently reversed the PMA-induced MMP-9 secretion and COX-2 expression.	Tetradecanoylphorbol Acetate	51-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
22523472-11	2012	Our results suggest that resveratrol may prevent BBB disruption during neuroinflammation by inhibiting MMP-9 and COX-2 and act as a pharmacological NF-kappaB signal transduction inhibitor independent of Sirt1.	Resveratrol	25-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-118
22109885-1	2012	Cyclooxygenase (COX)-2 is a key regulatory enzyme in the production of prostaglandins (PG) during various physiological processes.	Prostaglandins	71-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-22
22109885-1	2012	Cyclooxygenase (COX)-2 is a key regulatory enzyme in the production of prostaglandins (PG) during various physiological processes.	Prostaglandins	87-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-22
22109885-5	2012	The decrease in COX-2 is accompanied by a decrease in PG synthesis.	Prostaglandins	54-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-21
22109885-7	2012	Pretreatment with 26S proteasome inhibitor, MG132, significantly restores COX-2 protein and PG synthesis, indicating that COX-2 undergoes proteasomal degradation in the presence of TGF-beta.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	44-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
22109885-7	2012	Pretreatment with 26S proteasome inhibitor, MG132, significantly restores COX-2 protein and PG synthesis, indicating that COX-2 undergoes proteasomal degradation in the presence of TGF-beta.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	44-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-127
22109885-7	2012	Pretreatment with 26S proteasome inhibitor, MG132, significantly restores COX-2 protein and PG synthesis, indicating that COX-2 undergoes proteasomal degradation in the presence of TGF-beta.	Prostaglandins	92-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-127
22071254-1	2012	A series of 2,5-diaryl substituted furans functionalized with several amino acids were synthesized and evaluated as the cyclooxygenases COX-1 and COX-2 enzymes inhibitors.	2,5-diaryl substituted furans	12-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	146-151
22071254-2	2012	The proline-substituted compound inhibited PGE(2) secretion by LPS-stimulated neutrophils, suggesting selectivity for COX-2.	Proline	4-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-123
22844609-4	2012	Ibuprofen is a well-known effective and well-tolerated anti-COX (anti-COX1 and COX2) compound.	Ibuprofen	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-83
22408444-3	2012	The presence of a large amount of Mg(II), Ni(II), Al(III), Mn(II) and Co(II) ions did affect the iron(III) extraction.	ferric sulfate	97-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-76
22048655-2	2012	NS398 is an NSAID that inhibits COX-2 expression and induces tumor apoptosis via other pathways.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	0-5	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-37
22262978-5	2012	PGE(2) concentrations are reduced in AERD reflecting diminished expression of cyclooxygenase (COX)-2.	Dinoprostone	0-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-100
22262978-6	2012	IL-4 can inhibit basal and stimulated expression of COX-2 and microsomal PGE synthase 1 leading to decreased capacity for PGE(2) secretion.	Dinoprostone	122-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-57
21833656-2	2012	The Cu(II) and Zn(II) complexes could differentiate the palindromic sequences 5"-CATATG-3" and 5"-GTATAC-3", whereas the Co(II) analogue could not.	cu(ii)	4-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-127
21833656-2	2012	The Cu(II) and Zn(II) complexes could differentiate the palindromic sequences 5"-CATATG-3" and 5"-GTATAC-3", whereas the Co(II) analogue could not.	Zinc	15-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-127
22328955-5	2012	DESIGN: Using commercially available in-vitro biochemical assays, sinecatechins were tested for their activity against matrix metalloproteinase (MMP-1, MMP-2, MMP-7, MMP-9); enzymes involved in oxidative stress (lipoxygenases and cyclooxygenases [COX-1, COX-2]); several growth factors (epidermal growth factor, platelet-derived growth factor, and transforming growth factor-beta); and extracellular signal-regulated kinases 1/2.	sinecatechins	66-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	254-259
23394447-7	2012	We found that exposure of BHY cells to nicotine (200 microg/mL for 6 hours) resulted in 2.9-fold induction of COX-2 expression as well as a 4-fold increase in VEGF levels compared with a control group.	Nicotine	39-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-115
23394447-0	2012	Change in nicotine-induced VEGF, PGE2 AND COX-2 expression following COX inhibition in human oral squamous cancer.	Nicotine	10-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47
22346896-1	2012	The title complex, [Co(C(4)H(5)O(6))(2)(H(2)O)(2)] 2H(2)O, contains a Co(II) ion, two single deprotonated tartrate anions, two coordinated water mol-ecules and two lattice water mol-ecules.	co(c(4)h	20-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-76
22346896-1	2012	The title complex, [Co(C(4)H(5)O(6))(2)(H(2)O)(2)] 2H(2)O, contains a Co(II) ion, two single deprotonated tartrate anions, two coordinated water mol-ecules and two lattice water mol-ecules.	h(2)o)(2)] 2h(2)o	40-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-76
22346896-2	2012	The coordination geometry of the Co(II) ion is a distorted octa-hedron with two O atoms from two coordinated water mol-ecules occupying cis positions in the equatorial plane and four O atoms from two hydrogen tartrate ions occupying the remaining positions.	octa-hedron	59-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-39
22346896-2	2012	The coordination geometry of the Co(II) ion is a distorted octa-hedron with two O atoms from two coordinated water mol-ecules occupying cis positions in the equatorial plane and four O atoms from two hydrogen tartrate ions occupying the remaining positions.	Water	109-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-39
22346896-2	2012	The coordination geometry of the Co(II) ion is a distorted octa-hedron with two O atoms from two coordinated water mol-ecules occupying cis positions in the equatorial plane and four O atoms from two hydrogen tartrate ions occupying the remaining positions.	bitartrate	200-217	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-39
22068350-0	2012	COX-2-dependent and -independent biosynthesis of dihydroxy-arachidonic acids in activated human leukocytes.	dihydroxy-arachidonic acids	49-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
22068350-2	2012	Here, we analyzed the contribution of cyclooxygenase (COX)-2 to the biosynthesis of 5,15-diHETE and 5,11-diHETE in isolated human leukocytes activated with lipopolysaccharide and calcium ionophore A23187.	5,15-dihydroxy-6,8,11,13-eicosatetraenoic acid	84-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-60
22068350-2	2012	Here, we analyzed the contribution of cyclooxygenase (COX)-2 to the biosynthesis of 5,15-diHETE and 5,11-diHETE in isolated human leukocytes activated with lipopolysaccharide and calcium ionophore A23187.	5,11-diHETE	100-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-60
22068350-2	2012	Here, we analyzed the contribution of cyclooxygenase (COX)-2 to the biosynthesis of 5,15-diHETE and 5,11-diHETE in isolated human leukocytes activated with lipopolysaccharide and calcium ionophore A23187.	Calcium	179-186	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-60
22068350-2	2012	Here, we analyzed the contribution of cyclooxygenase (COX)-2 to the biosynthesis of 5,15-diHETE and 5,11-diHETE in isolated human leukocytes activated with lipopolysaccharide and calcium ionophore A23187.	Calcimycin	197-203	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-60
22068350-3	2012	Transformation of arachidonic acid was initiated by 5-LOX providing 5S-HETE as a substrate for COX-2 forming 5S,15S-diHETE, 5S,15R-diHETE, and 5S,11R-diHETE as shown by LC/MS and chiral phase HPLC analyses.	Arachidonic Acid	18-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-100
23964444-1	2012	Nonsteroidal anti-inflammatory Drugs (NSAIDs) is one of the most commonly use medication for treatment of knee osteoarthritis which has the analgesic and anti-inflammation by inhibition of prostaglandin synthesis via COX-1 and COX-2 isoenzyme.	Prostaglandins	189-202	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	227-232
21847707-2	2012	Celecoxib, the selective COX-2 nonsteroidal anti-inflammatory drug, has anti-neoplastic activity against several malignancies.	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-30
21847707-3	2012	Accumulating evidence suggests that several COX-2-independent mechanisms may also be involved in the anti-tumor effects of celecoxib.	Celecoxib	123-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-49
22072783-3	2012	In this study, we found that expression of both circulating IFN-lambda1 and COX2-derived prostaglandin E2 (PGE2) was coordinately elevated in a cohort of influenza patients compared to healthy individuals.	Dinoprostone	89-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-80
22001128-4	2012	Since safe aspirin regimens can only achieve a partial and transitory inhibition of cox-2, it may be feasible to complement the cancer-protective benefit of aspirin with other measures which decrease cox-2 expression or which limit the bioactivity of cox-2-derived PGE2.	Aspirin	11-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-89
22001128-8	2012	Ancillary antioxidant measures - phase 2 inducing phytochemicals, melatonin, N-acetylcysteine, and astaxanthin - may also aid cox-2 down-regulation.	Melatonin	66-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-131
22001128-8	2012	Ancillary antioxidant measures - phase 2 inducing phytochemicals, melatonin, N-acetylcysteine, and astaxanthin - may also aid cox-2 down-regulation.	Acetylcysteine	77-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-131
22001128-8	2012	Ancillary antioxidant measures - phase 2 inducing phytochemicals, melatonin, N-acetylcysteine, and astaxanthin - may also aid cox-2 down-regulation.	astaxanthine	99-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-131
22001128-9	2012	The cancer protection often associated with high-normal vitamin D status may be attributable, in part, to the ability of the activated vitamin D receptor to decrease cox-2 expression while promoting PGE2 catabolism and suppressing the expression of PGE2 receptors.	Vitamin D	56-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	166-171
22001128-13	2012	Soy isoflavones, linked to reduced cancer risk in Asian epidemiology, may suppress cox-2 induction by activating ERbeta.	Isoflavones	4-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
22108298-8	2012	Piceatannol also inhibits JAK-1, which is a key member of the STAT pathway that is crucial in controlling cellular activities in response to extracellular cytokines and is a COX-2-inducible enzyme involved in inflammation and carcinogenesis.	3,3',4,5'-tetrahydroxystilbene	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	174-179
22582102-11	2012	CONCLUSION: The current study estimated the efficacy of acetaminophen, nsNSAIDs, and COX-2 selective NSAIDs in OA and found that etoricoxib 30 mg is likely to result in the greatest improvements in pain and physical function.	Etoricoxib	129-139	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-90
23056258-12	2012	CONCLUSIONS/SIGNIFICANCE: A COII-based identification system should be more effective in identifying lachnine species than COI or Cytb.	lachnine	101-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-32
22844504-9	2012	Finally, MC-12 suppressed the induction of COX-2 expression, the level of PGE(2) in the colon and PGE(2) metabolite in serum.	mc-12	9-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
22701738-11	2012	COX-2 was transcriptionally upregulated by FGFR1 and caused increased intracellular prostaglandin E(2) levels, which promoted migration.	Dinoprostone	84-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
22412931-7	2012	Furthermore butyrate treatment was seen to restore GSTA1/A2 mRNA levels, protein expression and catalytic activity and to control NF-kappaB activation, COX-2, ICAM-1 and the release of pro-inflammatory cytokine.	Butyrates	12-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-157
22187234-2	2012	We investigated the effect of a short-term therapy of celecoxib, a COX-2 inhibitor, with or without doxycycline, an MMP inhibitor, after coronary stenting on inflammatory biomarkers and neointimal hyperplasia.	Celecoxib	54-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-72
22052578-2	2011	With the addition of up to eight iodine substituents (purple; see picture), there is a fall in the E(1/2)(Co(III)/Co(II)) value from -1.80 V to -0.68 V (vs. Fc(+)/Fc; Fc = ferrocene).	Iodine	33-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-120
22052578-2	2011	With the addition of up to eight iodine substituents (purple; see picture), there is a fall in the E(1/2)(Co(III)/Co(II)) value from -1.80 V to -0.68 V (vs. Fc(+)/Fc; Fc = ferrocene).	fc(+)	157-162	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-120
22052578-2	2011	With the addition of up to eight iodine substituents (purple; see picture), there is a fall in the E(1/2)(Co(III)/Co(II)) value from -1.80 V to -0.68 V (vs. Fc(+)/Fc; Fc = ferrocene).	Fc(alpha) receptor	157-159	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-120
22052578-2	2011	With the addition of up to eight iodine substituents (purple; see picture), there is a fall in the E(1/2)(Co(III)/Co(II)) value from -1.80 V to -0.68 V (vs. Fc(+)/Fc; Fc = ferrocene).	ferrocene	172-181	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-120
22091869-0	2011	Binding of ibuprofen, ketorolac, and diclofenac to COX-1 and COX-2 studied by saturation transfer difference NMR.	Ibuprofen	11-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-66
22091869-0	2011	Binding of ibuprofen, ketorolac, and diclofenac to COX-1 and COX-2 studied by saturation transfer difference NMR.	Ketorolac	22-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-66
22091869-0	2011	Binding of ibuprofen, ketorolac, and diclofenac to COX-1 and COX-2 studied by saturation transfer difference NMR.	Diclofenac	37-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-66
22091869-2	2011	Here we report the application of STD-NMR to characterize the binding of the anti-inflammatory drugs ibuprofen, diclofenac, and ketorolac to COX-1 and COX-2.	Ibuprofen	101-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-156
22091869-2	2011	Here we report the application of STD-NMR to characterize the binding of the anti-inflammatory drugs ibuprofen, diclofenac, and ketorolac to COX-1 and COX-2.	Diclofenac	112-122	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-156
22091869-2	2011	Here we report the application of STD-NMR to characterize the binding of the anti-inflammatory drugs ibuprofen, diclofenac, and ketorolac to COX-1 and COX-2.	Ketorolac	128-137	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-156
22091869-3	2011	Using well-studied COX inhibitors and by comparing STD signals with crystallographic structures, we show that there is a relation between the orientations of ibuprofen and diclofenac in the COX-2 active site and the relative STD responses detected in the NMR experiments.	Ibuprofen	158-167	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	190-195
21916491-2	2011	Stable isotope dilution chiral liquid chromatography (LC)-electron capture atmospheric pressure chemical ionization (ECAPCI)/mass spectrometry (MS) was used to quantify COX-2-derived eicosanoids in the human colorectal adenocarcinoma (LoVo) epithelial cell line, which expresses both COX-2 and 15-hydroxyprostaglandin dehydrogenase (15-PGDH).	Eicosanoids	183-194	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	169-174
21996590-0	2011	Molecular structure and spectroscopic studies on novel complexes of coumarin-3-carboxylic acid with Ni(II), Co(II), Zn(II) and Mn(II) ions based on density functional theory.	coumarin-3-carboxylic acid	68-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-114
21996590-1	2011	Novel Ni(II), Co(II), Zn(II) and Mn(II) complexes of coumarin-3-carboxylic acid (HCCA) were studied at experimental and theoretical levels.	coumarin-3-carboxylic acid	53-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-20
21996590-1	2011	Novel Ni(II), Co(II), Zn(II) and Mn(II) complexes of coumarin-3-carboxylic acid (HCCA) were studied at experimental and theoretical levels.	2-hydroxychromene-2-carboxylate	81-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-20
21996590-5	2011	The model calculations predicted pseudo octahedral trans-[M(CCA2)(2)(H(2)O)(2)] structures for the Zn(II), Ni(II) and Co(II) complexes and a binuclear [Mn(2)(CCA2)(4)(H(2)O)(2)] structure.	Zinc	99-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-124
22034624-1	2011	Our theoretical studies of the standard reduction potentials of the molecular complex [Co(II)(dmgBF(2))(2)](0) (dmgBF(2) = difluoro-boryldimethylglyoximate) in acetonitrile solution shed light on its electrocatalytic mechanism for hydrogen production.	acetonitrile	160-172	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-92
22034624-1	2011	Our theoretical studies of the standard reduction potentials of the molecular complex [Co(II)(dmgBF(2))(2)](0) (dmgBF(2) = difluoro-boryldimethylglyoximate) in acetonitrile solution shed light on its electrocatalytic mechanism for hydrogen production.	Hydrogen	231-239	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-92
22015544-0	2011	Self-assembled Co(II) molecular squares incorporating the bridging ligand 4,7-phenanthrolino-5,6:5",6"-pyrazine.	4,7-phenanthrolino-5,6:5",6"-pyrazine	74-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-21
21431842-2	2011	In this study, we investigated the anti-tumor effects of the selective COX-2 inhibitor etodolac on endometrial cancer patients.	Etodolac	87-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-76
21431842-6	2011	RESULTS: Surgical specimens from COX-2 positive endometrial cancer patients treated with etodolac had significantly reduced expression levels of COX-2, Ki-67, p53, p21, p27, and cyclin D1 as determined by immunohistochemistry, while AI was not affected.	Etodolac	89-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-38
21431842-6	2011	RESULTS: Surgical specimens from COX-2 positive endometrial cancer patients treated with etodolac had significantly reduced expression levels of COX-2, Ki-67, p53, p21, p27, and cyclin D1 as determined by immunohistochemistry, while AI was not affected.	Etodolac	89-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-150
21431842-8	2011	CONCLUSIONS: The selective COX-2 inhibitor etodolac showed anti-proliferative effects by suppressing COX-2 and cell-cycle regulator protein expression in patients with endometrial cancer positive for COX-2 expression.	Etodolac	43-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-32
21431842-8	2011	CONCLUSIONS: The selective COX-2 inhibitor etodolac showed anti-proliferative effects by suppressing COX-2 and cell-cycle regulator protein expression in patients with endometrial cancer positive for COX-2 expression.	Etodolac	43-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-106
21431842-8	2011	CONCLUSIONS: The selective COX-2 inhibitor etodolac showed anti-proliferative effects by suppressing COX-2 and cell-cycle regulator protein expression in patients with endometrial cancer positive for COX-2 expression.	Etodolac	43-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-106
22210040-8	2011	The increments of COX-2 expression and PGE(2) production by acidic medium were decreased by pretreatment with PD98059 or SB202190, respectively.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	110-117	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-23
22210040-8	2011	The increments of COX-2 expression and PGE(2) production by acidic medium were decreased by pretreatment with PD98059 or SB202190, respectively.	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	121-129	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-23
21911040-4	2011	In the present study, we explored the actions of trichostatin A (TSA), a potent HDAC inhibitor, on lipopolysaccharide (LPS)-induced cyclooxygenase (COX)-2 expression in human umbilical vascular endothelial cells (HUVECs).	trichostatin A	49-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	148-154
21911040-4	2011	In the present study, we explored the actions of trichostatin A (TSA), a potent HDAC inhibitor, on lipopolysaccharide (LPS)-induced cyclooxygenase (COX)-2 expression in human umbilical vascular endothelial cells (HUVECs).	trichostatin A	65-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	148-154
21911040-7	2011	RESULTS: The LPS-induced cox-2 messenger RNA and protein were markedly suppressed by TSA.	trichostatin A	85-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-30
21911040-10	2011	TSA suppression of JNK and p38MAPK phosphorylation and subsequent COX-2 expression were restored by selective inhibition of MKP-1 using MKP-1 siRNA.	trichostatin A	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-71
21911040-12	2011	In conclusion, TSA may cause MKP-1 activation to dephosphorylate JNK and p38MAPK, leading to the downregulation of COX-2 in HUVECs stimulated by LPS, a proinflammatory stimulus.	trichostatin A	15-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-120
21479633-7	2011	DHA significantly inhibited NF-kappaB DNA-binding activity, so as to tremendously decrease the expression of NF-kappaB-targeted proangiogenic gene products: VEGF, IL-8, COX-2, and MMP-9 in vitro.	artenimol	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	169-174
22002714-2	2011	Prostaglandin E2 (PGE(2)) is the most abundant prostanoid in the human body, and synthesis of PGE(2) is driven by cyclooxygenase enzymes including COX-2.	Dinoprostone	0-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-152
22002714-2	2011	Prostaglandin E2 (PGE(2)) is the most abundant prostanoid in the human body, and synthesis of PGE(2) is driven by cyclooxygenase enzymes including COX-2.	Prostaglandins E	18-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-152
22002714-2	2011	Prostaglandin E2 (PGE(2)) is the most abundant prostanoid in the human body, and synthesis of PGE(2) is driven by cyclooxygenase enzymes including COX-2.	Prostaglandins	47-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-152
22002714-2	2011	Prostaglandin E2 (PGE(2)) is the most abundant prostanoid in the human body, and synthesis of PGE(2) is driven by cyclooxygenase enzymes including COX-2.	Prostaglandins E	94-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-152
22068350-3	2012	Transformation of arachidonic acid was initiated by 5-LOX providing 5S-HETE as a substrate for COX-2 forming 5S,15S-diHETE, 5S,15R-diHETE, and 5S,11R-diHETE as shown by LC/MS and chiral phase HPLC analyses.	5-hydroxy-6,8,11,14-eicosatetraenoic acid	68-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-100
22068350-3	2012	Transformation of arachidonic acid was initiated by 5-LOX providing 5S-HETE as a substrate for COX-2 forming 5S,15S-diHETE, 5S,15R-diHETE, and 5S,11R-diHETE as shown by LC/MS and chiral phase HPLC analyses.	5,15-dihydroxy-6,8,11,13-eicosatetraenoic acid	109-122	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-100
22068350-3	2012	Transformation of arachidonic acid was initiated by 5-LOX providing 5S-HETE as a substrate for COX-2 forming 5S,15S-diHETE, 5S,15R-diHETE, and 5S,11R-diHETE as shown by LC/MS and chiral phase HPLC analyses.	5S,15R-diHETE	124-137	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-100
22068350-3	2012	Transformation of arachidonic acid was initiated by 5-LOX providing 5S-HETE as a substrate for COX-2 forming 5S,15S-diHETE, 5S,15R-diHETE, and 5S,11R-diHETE as shown by LC/MS and chiral phase HPLC analyses.	5,11-diHETE	143-156	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-100
22068350-5	2012	The COX-2 specific inhibitor NS-398 reduced the levels of 5,15-diHETE to below 0.02 ng/106 cells in four of six samples.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	29-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
22068350-5	2012	The COX-2 specific inhibitor NS-398 reduced the levels of 5,15-diHETE to below 0.02 ng/106 cells in four of six samples.	5,15-dihydroxy-6,8,11,13-eicosatetraenoic acid	58-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
22068350-10	2012	The contribution of COX-2 to the biosynthesis of dihydroxylated derivatives of arachidonic acid provides evidence for functional coupling with 5-LOX in activated human leukocytes.	Arachidonic Acid	79-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-25
22878602-1	2012	The aim of this in vitro study was to examine the possible effect of [2-methyl-5-(4-methylsulphonyl)phenyl-1-phenyl-3-(2-n-propyloxyethyl)]-1H-pyrrole (VA441), a new selective cyclooxygenase (COX)-2 inhibitor, on human osteoarthritic (OA) chondrocyte cultivated in the presence or absence of interleukin-1beta (IL-1beta).	Pyrroles	140-150	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	176-198
22072783-3	2012	In this study, we found that expression of both circulating IFN-lambda1 and COX2-derived prostaglandin E2 (PGE2) was coordinately elevated in a cohort of influenza patients compared to healthy individuals.	Dinoprostone	107-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-80
22489690-9	2012	These results show that during early exposure of Eca-109 cells to isorhamnetin, the NF-kappaB signaling pathway is activated and COX-2 expression increases, and this increase in expression partially inhibits isorhamnetin-induced apoptosis.	3-methylquercetin	66-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-134
22489690-9	2012	These results show that during early exposure of Eca-109 cells to isorhamnetin, the NF-kappaB signaling pathway is activated and COX-2 expression increases, and this increase in expression partially inhibits isorhamnetin-induced apoptosis.	3-methylquercetin	208-220	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-134
22166436-5	2012	Activation of the NF-kappaB death pathway has been shown to occur following microglial activation related release of Cox-2, IL-1beta, and Toll-like receptor activation, resulting in increased degeneration of DA neurons of the SNpc.	Dopamine	208-210	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-122
22047608-7	2012	NF-kappaB was activated by TNF-alpha after 24 h stimulation in a dose-dependent manner, and was significantly inactivated by the NF-kappaB inhibitor panepoxydone, which was associated with decreased PR-A and COX-2 expression (P &lt; 0.05) in not in labor deciduas.	panepoxydone	149-161	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	208-213
23166763-3	2012	We found that SFN indeed blocked PGE2 production in human A549 cancer cells not by inhibiting COX-2, but rather by suppressing the expression of microsomal prostaglandin E synthase (mPGES-1), the enzyme that directly synthesizes PGE2.	sulforaphane	14-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-99
23029074-15	2012	CONCLUSIONS/SIGNIFICANCE: Puerarin suppresses proliferation of ESCs induced by E(2)-BSA partly via impeding a rapid, non-genomic, membrane-initiated ERK pathway, and down-regulation of Cyclin D1, Cox-2 and Cyp19 are involved in the process.	puerarin	26-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	196-201
22984445-1	2012	Chromomycin A3 (Chro) is capable of forming a stable dimeric complex via chelation with Ni(II), Fe(II) and Co(II).	Chromomycin A3	0-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-113
22984445-1	2012	Chromomycin A3 (Chro) is capable of forming a stable dimeric complex via chelation with Ni(II), Fe(II) and Co(II).	Chromomycin A3	16-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-113
22984445-4	2012	Kinetic analyses using surface plasmon resonance (SPR) showed that Ni(II)(Chro)(2) exhibited the highest K(a) with a value of 1.26 x 10(7) M(-1), which is approximately 1.6- and 3.7-fold higher than the K(a) values obtained for Co(II)(Chro)(2) and Fe(II)(Chro)(2), respectively.	Nickel(2+)	67-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	228-234
22984445-4	2012	Kinetic analyses using surface plasmon resonance (SPR) showed that Ni(II)(Chro)(2) exhibited the highest K(a) with a value of 1.26 x 10(7) M(-1), which is approximately 1.6- and 3.7-fold higher than the K(a) values obtained for Co(II)(Chro)(2) and Fe(II)(Chro)(2), respectively.	Chromomycin A3	74-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	228-234
22984445-6	2012	In the DNA integrity assays, the DNA cleavage rate of Co(II)(Chro)(2) (1.2 x 10(-3) s(-1)) is higher than those of Fe(II)(Chro)(2) and Ni(II)(Chro)(2), which were calculated to be 1 x 10(-4) and 3.1 x 10(-4) s(-1), respectively.	ammonium ferrous sulfate	115-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-60
22984445-6	2012	In the DNA integrity assays, the DNA cleavage rate of Co(II)(Chro)(2) (1.2 x 10(-3) s(-1)) is higher than those of Fe(II)(Chro)(2) and Ni(II)(Chro)(2), which were calculated to be 1 x 10(-4) and 3.1 x 10(-4) s(-1), respectively.	ni(ii	135-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-60
21835258-0	2012	The COX-2 inhibitor Celecoxib enhances the sensitivity of KB/VCR oral cancer cell lines to Vincristine by down-regulating P-glycoprotein expression and function.	Celecoxib	20-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
21835258-0	2012	The COX-2 inhibitor Celecoxib enhances the sensitivity of KB/VCR oral cancer cell lines to Vincristine by down-regulating P-glycoprotein expression and function.	Vincristine	91-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
21835258-3	2012	Using the MTT method, we investigated the influence of the COX-2 selective inhibitor Celecoxib on the proliferation of KB/VCR oral cancer cell lines and analyzed the effect of Celecoxib on the regulation of P-glycoprotein (P-gp) expression and function.	monooxyethylene trimethylolpropane tristearate	10-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-64
21835258-3	2012	Using the MTT method, we investigated the influence of the COX-2 selective inhibitor Celecoxib on the proliferation of KB/VCR oral cancer cell lines and analyzed the effect of Celecoxib on the regulation of P-glycoprotein (P-gp) expression and function.	Celecoxib	85-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-64
22141388-1	2011	Celecoxib (Celebrex ) was the first cyclo-oxygenase (COX)-2 selective inhibitor (coxib) to be introduced into clinical practice.	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-59
22141388-1	2011	Celecoxib (Celebrex ) was the first cyclo-oxygenase (COX)-2 selective inhibitor (coxib) to be introduced into clinical practice.	Celecoxib	11-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-59
22011743-0	2011	Isomorphous Co(II) and Ni(II) antiferromagnets based on mixed azide- and carboxylate-bridged chains: metamagnetism and single-chain dynamics.	Azides	62-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-18
22011743-0	2011	Isomorphous Co(II) and Ni(II) antiferromagnets based on mixed azide- and carboxylate-bridged chains: metamagnetism and single-chain dynamics.	carboxylate	73-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-18
22011743-1	2011	Two isomorphous Co(II) and Ni(II) coordination polymers with azide and the 4-(4-pyridyl)benzoic acid N-oxide ligand (4,4-Hopybz) were synthesized, and structurally and magnetically characterized.	Azides	61-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-22
22011743-1	2011	Two isomorphous Co(II) and Ni(II) coordination polymers with azide and the 4-(4-pyridyl)benzoic acid N-oxide ligand (4,4-Hopybz) were synthesized, and structurally and magnetically characterized.	4-(4-pyridyl)benzoic acid n-oxide	75-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-22
22091869-3	2011	Using well-studied COX inhibitors and by comparing STD signals with crystallographic structures, we show that there is a relation between the orientations of ibuprofen and diclofenac in the COX-2 active site and the relative STD responses detected in the NMR experiments.	Diclofenac	172-182	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	190-195
22091869-4	2011	On the basis of this analysis, we propose that ketorolac should bind to the COX-2 active site in an orientation similar to that of diclofenac.	Ketorolac	47-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-81
22185664-4	2011	As with exercise, it is well known that moderate exercise is good for health, whereas excessive exercise is not.Severe oxidative stress activates nuclear transcriptional factor kappa B (NFkappaB), resulting in an inflammatory response and tissue injury via the production of COX2, PGE2, and cytokines.	Dinoprostone	281-285	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	275-279
21916491-6	2011	These data confirmed COX-2 and 15-PGDH as enzymes responsible for 11-oxo-ETE biosynthesis.	11-oxo-ETE	66-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-26
21916491-11	2011	These results show that 11-oxo-ETE is a novel COX-2/15-PGDH-derived eicosanoid, which inhibits endothelial cell proliferation with a potency that is similar to that observed for 15d-PGJ(2).	11-oxo-ETE	24-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
21916491-11	2011	These results show that 11-oxo-ETE is a novel COX-2/15-PGDH-derived eicosanoid, which inhibits endothelial cell proliferation with a potency that is similar to that observed for 15d-PGJ(2).	Eicosanoids	68-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
21954011-0	2011	Macrophage response to high number of titanium particles is cytotoxic and COX-2 mediated and it is not affected by the particle"s endotoxin content or the cleaning treatment.	Titanium	38-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
22070750-2	2011	Herein, few-layered graphene oxide nanosheets were synthesized from graphite using the modified Hummers method, and were used as sorbents for the removal of Cd(II) and Co(II) ions from large volumes of aqueous solutions.	graphene oxide	20-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	168-174
22070750-4	2011	The results indicated that Cd(II) and Co(II) sorption on graphene oxide nanosheets was strongly dependent on pH and weakly dependent on ionic strength.	graphene oxide	57-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-44
22070750-5	2011	The abundant oxygen-containing functional groups on the surfaces of graphene oxide nanosheets played an important role on Cd(II) and Co(II) sorption.	Oxygen	13-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	133-139
22070750-5	2011	The abundant oxygen-containing functional groups on the surfaces of graphene oxide nanosheets played an important role on Cd(II) and Co(II) sorption.	graphene oxide	68-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	133-139
22070750-6	2011	The presence of humic acid reduced Cd(II) and Co(II) sorption on graphene oxide nanosheets at pH &lt; 8.	graphene oxide	65-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-52
22070750-7	2011	The maximum sorption capacities (C(smax)) of Cd(II) and Co(II) on graphene oxide nanosheets at pH 6.0 +- 0.1 and T = 303 K were about 106.3 and 68.2 mg/g, respectively, higher than any currently reported.	graphene oxide	66-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-62
22070750-8	2011	The thermodynamic parameters calculated from temperature-dependent sorption isotherms suggested that Cd(II) and Co(II) sorptions on graphene oxide nanosheets were endothermic and spontaneous processes.	graphene oxide	132-146	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-118
21986896-2	2011	Compound 1 is a polymer in which ligand L coordinates to tetrahedral Co(II) ions in a bidentate bridging fashion using the pyridine nitrogen and carbonyl oxygen atoms.	Polymers	16-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-75
21986896-2	2011	Compound 1 is a polymer in which ligand L coordinates to tetrahedral Co(II) ions in a bidentate bridging fashion using the pyridine nitrogen and carbonyl oxygen atoms.	pyridine	123-131	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-75
21986896-2	2011	Compound 1 is a polymer in which ligand L coordinates to tetrahedral Co(II) ions in a bidentate bridging fashion using the pyridine nitrogen and carbonyl oxygen atoms.	Nitrogen	132-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-75
26598342-8	2011	The toughest case met in this work is cobalt corrole, for which we studied the relative energy of several low-lying Co(II)-corrole pi radical states with respect to the Co(III) ground state.	cobalt corrole	38-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-121
22076957-0	2011	Exploring the effect of metal ions and counteranions on the structure and magnetic properties of five dodecanuclear Co(II) and Ni(II) clusters.	Metals	24-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-122
21986962-3	2011	In solution, the ligand LH forms octacationic, homometallic [2 x 2] grids with the individual labile metal ions Fe(II), Co(II), Cu(II), Zn(II), seemingly as mixtures of all possible isomers arising from the unsymmetrical nature of the ligand.	Luteinizing Hormone	24-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-126
22050369-0	2011	Pentanuclear cyanide-bridged complexes based on highly anisotropic Co(II) seven-coordinate building blocks: synthesis, structure, and magnetic behavior.	Cyanides	13-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-73
22050369-5	2011	In 4, the central and terminal Co(II) ions are bound to cyanide groups cis to one another on the bridging {Cr(CN)(6)}, whereas in 5, the connections are via trans cyanide ligands, resulting in the zigzag and linear structures observed, respectively.	Cyanides	56-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-37
22050369-5	2011	In 4, the central and terminal Co(II) ions are bound to cyanide groups cis to one another on the bridging {Cr(CN)(6)}, whereas in 5, the connections are via trans cyanide ligands, resulting in the zigzag and linear structures observed, respectively.	Chromium	107-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-37
22050369-5	2011	In 4, the central and terminal Co(II) ions are bound to cyanide groups cis to one another on the bridging {Cr(CN)(6)}, whereas in 5, the connections are via trans cyanide ligands, resulting in the zigzag and linear structures observed, respectively.	Cyanides	163-170	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-37
22199511-2	2011	The Co(II) atom is located on an inversion centre and displays a distorted octa-hedral coordination geometry defined by four O atoms of two 3-aza-niumyl-1-hy-droxy-propyl-idene-1,1-bis-phospho-nato ligands in the equatorial plane and two water mol-ecules located in axial positions.	3-aza	140-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
22199511-2	2011	The Co(II) atom is located on an inversion centre and displays a distorted octa-hedral coordination geometry defined by four O atoms of two 3-aza-niumyl-1-hy-droxy-propyl-idene-1,1-bis-phospho-nato ligands in the equatorial plane and two water mol-ecules located in axial positions.	niumyl-1-hy-droxy-propyl-idene-1,1-bis	146-184	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
22199511-2	2011	The Co(II) atom is located on an inversion centre and displays a distorted octa-hedral coordination geometry defined by four O atoms of two 3-aza-niumyl-1-hy-droxy-propyl-idene-1,1-bis-phospho-nato ligands in the equatorial plane and two water mol-ecules located in axial positions.	Dihydroxyacetone Phosphate	185-192	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
22199511-2	2011	The Co(II) atom is located on an inversion centre and displays a distorted octa-hedral coordination geometry defined by four O atoms of two 3-aza-niumyl-1-hy-droxy-propyl-idene-1,1-bis-phospho-nato ligands in the equatorial plane and two water mol-ecules located in axial positions.	Water	238-243	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
22199572-1	2011	In the title compound, [CoNa(2)(C(7)H(3)NO(4))(2)(H(2)O)(2)](n), the Co(II) atom is coordinated by two pyridine N atoms and four carboxyl-ate O atoms from two doubly deprotonated pyridine-2,6-dicarboxyl-ate ligands in a distorted octa-hedral geometry.	3)no	38-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-75
22199572-1	2011	In the title compound, [CoNa(2)(C(7)H(3)NO(4))(2)(H(2)O)(2)](n), the Co(II) atom is coordinated by two pyridine N atoms and four carboxyl-ate O atoms from two doubly deprotonated pyridine-2,6-dicarboxyl-ate ligands in a distorted octa-hedral geometry.	Water	50-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-75
22199572-1	2011	In the title compound, [CoNa(2)(C(7)H(3)NO(4))(2)(H(2)O)(2)](n), the Co(II) atom is coordinated by two pyridine N atoms and four carboxyl-ate O atoms from two doubly deprotonated pyridine-2,6-dicarboxyl-ate ligands in a distorted octa-hedral geometry.	pyridine	103-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-75
21840302-1	2011	Levels of cyclooxygenase (COX)-2 and its metabolite prostaglandin E(2) (PGE(2)) are frequently increased in colon cancer and other cancers including lung cancer.	Dinoprostone	52-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-32
21840302-1	2011	Levels of cyclooxygenase (COX)-2 and its metabolite prostaglandin E(2) (PGE(2)) are frequently increased in colon cancer and other cancers including lung cancer.	Dinoprostone	72-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-32
21840302-2	2011	Non-steroidal anti-inflammatory drugs are considered to have chemo-preventive effects on these diseases by reducing the biosynthesis of PGE(2) via their inhibition of COX-2.	Prostaglandins E	136-139	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	167-172
23394447-8	2012	Pretreatment with celecoxib inhibited nicotine-induced change in the expression of VEGF and COX-2.	Celecoxib	18-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-97
23394447-8	2012	Pretreatment with celecoxib inhibited nicotine-induced change in the expression of VEGF and COX-2.	Nicotine	38-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-97
23394447-9	2012	The results suggest that stimulation of COX-2 and VEGF expression can contribute as important factors in the tumorigenic action of nicotine in oral cancer progression.	Nicotine	131-139	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
23394447-10	2012	This effect can be blocked by celecoxib, suggesting an interaction of nicotine and COX-2 pathways.	Celecoxib	30-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
21964881-5	2011	The PCPP axis activity is autoregulated by way of a positive feedback circuit involving PGE(2)-mediated, p38 MAPK-dependent stabilization of COX-2 mRNA and COX-2 catalytic potentiation via its limited proteolytic cleavage (e.g., Ca(2+)-activated calpains).	polybis(carbophenoxypropane)	4-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	141-146
22037941-6	2011	Increased cyclooxygenase (COX)-2 expression has been described in a variety of human cancers, which has focused attention on TXA(2) as a downstream metabolite of the COX-2-derived PGH(2).	Thromboxane A2	125-131	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-32
22037941-6	2011	Increased cyclooxygenase (COX)-2 expression has been described in a variety of human cancers, which has focused attention on TXA(2) as a downstream metabolite of the COX-2-derived PGH(2).	Thromboxane A2	125-131	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	166-171
22037941-6	2011	Increased cyclooxygenase (COX)-2 expression has been described in a variety of human cancers, which has focused attention on TXA(2) as a downstream metabolite of the COX-2-derived PGH(2).	GH2 protein, human	180-183	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-32
22037941-6	2011	Increased cyclooxygenase (COX)-2 expression has been described in a variety of human cancers, which has focused attention on TXA(2) as a downstream metabolite of the COX-2-derived PGH(2).	GH2 protein, human	180-183	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	166-171
21380921-2	2011	These ligands produce catalytic hydrogen currents with Co(II) at peak potentials -1.24 V and -1.44 V vs. SCE respectively.	Hydrogen	32-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-61
22346776-5	2011	RESULTS: Both PGE(2) and PGI(2) productions were almost completely inhibited by the depletion of COX-2.	Prostaglandins E	14-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
22346776-5	2011	RESULTS: Both PGE(2) and PGI(2) productions were almost completely inhibited by the depletion of COX-2.	Prostaglandins I	25-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
21964881-5	2011	The PCPP axis activity is autoregulated by way of a positive feedback circuit involving PGE(2)-mediated, p38 MAPK-dependent stabilization of COX-2 mRNA and COX-2 catalytic potentiation via its limited proteolytic cleavage (e.g., Ca(2+)-activated calpains).	polybis(carbophenoxypropane)	4-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	156-161
21964881-5	2011	The PCPP axis activity is autoregulated by way of a positive feedback circuit involving PGE(2)-mediated, p38 MAPK-dependent stabilization of COX-2 mRNA and COX-2 catalytic potentiation via its limited proteolytic cleavage (e.g., Ca(2+)-activated calpains).	Dinoprostone	88-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	141-146
21964881-5	2011	The PCPP axis activity is autoregulated by way of a positive feedback circuit involving PGE(2)-mediated, p38 MAPK-dependent stabilization of COX-2 mRNA and COX-2 catalytic potentiation via its limited proteolytic cleavage (e.g., Ca(2+)-activated calpains).	Dinoprostone	88-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	156-161
21414766-5	2011	Nicotinamide treatment resulted in a significant reduction of basal and/or LPS-stimulated release and gene expression of the pro-inflammatory cytokines TNF-alpha, IL-6 and the chemokine IL-8, and the release of the prostaglandins PGE(2) and PGF(2)alpha and cyclooxygenase (COX)-2 mRNA expression.	Niacinamide	0-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	273-279
22047035-2	2011	The metric parameters about the metal center and the pre-edge region of the Co K-edge X-ray absorption spectrum were reproduced by density functional theory (DFT), providing a qualitative description of the Co-NO bonding interaction as a Co(II) (S(Co) = 3/2) metal center, antiferromagnetically coupled to a triplet NO(-) anion (S(NO) = 1), an interpretation of the electronic structure that was validated by ab initio multireference methods (CASSCF/MRCI).	co-no	207-212	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	238-244
22114865-0	2011	An observational study of the discrediting of COX-2 NSAIDs in Australia: Vioxx or class effect?	rofecoxib	73-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
22114865-3	2011	The overall objective of this paper was to examine the impact of this discrediting event on dispensing of the COX-2 class of medicines, by describing medicine switching behaviours of older Australian women using rofecoxib in September 2004; the uptake of other COX-2s; and the characteristics of women who continued using a COX-2.	rofecoxib	212-221	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-115
22114865-11	2011	Continuous rofecoxib users overwhelmingly switched to another COX-2 and remained continuing COX-2 users for at least 100 days post-switch.	rofecoxib	11-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
22114865-11	2011	Continuous rofecoxib users overwhelmingly switched to another COX-2 and remained continuing COX-2 users for at least 100 days post-switch.	rofecoxib	11-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-97
21945125-1	2011	Details of complex formation kinetics are reported for tetrakis(2-hydroxyethyl) substituted cyclen (L(1)) and cyclam (L(2)) with Cu(II) and Co(II).	tetrakis(2-hydroxyethyl)	55-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-146
21945125-1	2011	Details of complex formation kinetics are reported for tetrakis(2-hydroxyethyl) substituted cyclen (L(1)) and cyclam (L(2)) with Cu(II) and Co(II).	cyclam	110-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-146
22047035-2	2011	The metric parameters about the metal center and the pre-edge region of the Co K-edge X-ray absorption spectrum were reproduced by density functional theory (DFT), providing a qualitative description of the Co-NO bonding interaction as a Co(II) (S(Co) = 3/2) metal center, antiferromagnetically coupled to a triplet NO(-) anion (S(NO) = 1), an interpretation of the electronic structure that was validated by ab initio multireference methods (CASSCF/MRCI).	Cobalt	248-251	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	238-244
22113581-4	2011	Interestingly, the PGE(2) inhibitory activity of BDMC33 is not attributed to inhibition of the COX enzyme activities, but rather BDMC33 selectively down-regulated the expression of COX-2.	2,6-bis(2,5-dimethoxybenzylidene)cyclohexanone	129-135	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	181-186
21967897-6	2011	C2BBe1 cells, an intestinal epithelial cell line, were treated with the COX-2 inhibitor NS-398, PGD(2), or vehicle and stimulated with cytokines.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	88-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
21937683-1	2011	Prostaglandin E(2) (PGE(2)), the most abundant COX-2-derived prostaglandin found in colorectal cancer, promotes tumor cell proliferation and survival via multiple signaling pathways.	Dinoprostone	0-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
21937683-1	2011	Prostaglandin E(2) (PGE(2)), the most abundant COX-2-derived prostaglandin found in colorectal cancer, promotes tumor cell proliferation and survival via multiple signaling pathways.	Prostaglandins E	20-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
21937683-1	2011	Prostaglandin E(2) (PGE(2)), the most abundant COX-2-derived prostaglandin found in colorectal cancer, promotes tumor cell proliferation and survival via multiple signaling pathways.	Prostaglandins	61-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
21833390-3	2011	Compound 2 having a I4(1)/a space group exhibits a tetranuclear Co(II) cluster with a cubane topology in which the central Co(II) ion and oxygen atoms from bm occupy the alternate vertices of the cube.	Oxygen	138-144	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-70
21889841-0	2011	Chelating agent free-solid phase extraction (CAF-SPE) of Co(II), Cu(II) and Cd(II) by new nano hybrid material (ZrO2/B2O3).	caf-spe	45-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-63
21889841-0	2011	Chelating agent free-solid phase extraction (CAF-SPE) of Co(II), Cu(II) and Cd(II) by new nano hybrid material (ZrO2/B2O3).	zirconium oxide	112-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-63
21889841-0	2011	Chelating agent free-solid phase extraction (CAF-SPE) of Co(II), Cu(II) and Cd(II) by new nano hybrid material (ZrO2/B2O3).	boron oxide	117-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-63
21889841-1	2011	New nano hybrid material (ZrO(2)/B(2)O(3)) was synthesized and applied as a sorbent for the separation and/or preconcentration of Co(II), Cu(II) and Cd(II) in water and tea leaves prior to their determination by flame atomic absorption spectrometry.	zro(2)	26-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	130-136
21889841-1	2011	New nano hybrid material (ZrO(2)/B(2)O(3)) was synthesized and applied as a sorbent for the separation and/or preconcentration of Co(II), Cu(II) and Cd(II) in water and tea leaves prior to their determination by flame atomic absorption spectrometry.	Water	159-164	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	130-136
21834936-11	2011	CONCLUSION: Selective COX-2 inhibitors may be unsafe in subjects with urticaria and/or angioedema caused by hypersensitivity reactions to NSAIDs with cross-intolerance if they are intolerant to paracetamol.	Acetaminophen	194-205	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-27
22065790-8	2011	Finally, application of the COX-2-selective inhibitor NS-398 fully prevented CD83-triggered inhibition of T-cell responses.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	54-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
22147962-6	2011	Furthermore, COX-2 siRNA treatment inhibited cell proliferation (P &lt; 0.01) and induced apoptosis in EC109 cells, as determined by an MTT assay and by flow cytometry, respectively.	monooxyethylene trimethylolpropane tristearate	136-139	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
22051946-1	2011	The crystal structure of the cobalt(II) carbonate-based compound cobalt(II) dicarbonate trisodium chloride, Co(CO(3))(2)Na(3)Cl, grown from a water-ethanol mixture, exhibits a three-dimensional network of corner-sharing {Co(4)(mu(3)-CO(3))(4)} tetrahedral building blocks, in which the Co(II) centres define a pyrochlore lattice and reside in a slightly distorted octahedral Co(O-CO(2))(6) environment.	cobalt(ii) dicarbonate trisodium chloride	65-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	286-292
22051946-1	2011	The crystal structure of the cobalt(II) carbonate-based compound cobalt(II) dicarbonate trisodium chloride, Co(CO(3))(2)Na(3)Cl, grown from a water-ethanol mixture, exhibits a three-dimensional network of corner-sharing {Co(4)(mu(3)-CO(3))(4)} tetrahedral building blocks, in which the Co(II) centres define a pyrochlore lattice and reside in a slightly distorted octahedral Co(O-CO(2))(6) environment.	co(co(3))(2)na(3)cl	108-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	286-292
22051946-3	2011	Antiferromagnetic coupling between adjacent Co(II) centres, mediated by carbonate bridges, results in geometric spin frustration which is typical for pyrochlore networks.	Carbonates	72-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-50
22219767-1	2011	The Co(II) atom in the title salt, [Co(H(2)O)(6)](C(13)H(10)NO(3))(2) 2H(2)O, lies on a center of inversion in an octa-hedron of water mol-ecules.	Water	39-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
21834936-13	2011	In subjects with hypersensitivity to NSAIDs and intolerance to paracetamol, selective COX-2 inhibitors should be administered as a controlled, incremental dose provocation test to assess tolerance.	Acetaminophen	63-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-91
22219767-1	2011	The Co(II) atom in the title salt, [Co(H(2)O)(6)](C(13)H(10)NO(3))(2) 2H(2)O, lies on a center of inversion in an octa-hedron of water mol-ecules.	Water	129-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
21778329-7	2011	Is the efficacy of celecoxib in particular or NSAIDs in general due to their off-target effects or to their effects on COX-1 and COX-2?	Celecoxib	19-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-134
21564090-8	2011	The results for COX-2, which is often up-regulated under pathological conditions, are of particular note in that they offer a mechanism by which up-regulated COX-2 may promote neuronal excitation by suppressing DSE while enhancing conversion of 2-AG to PGE(2) -glycerol ester under pathological conditions.	glyceryl 2-arachidonate	245-249	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-21
21564090-8	2011	The results for COX-2, which is often up-regulated under pathological conditions, are of particular note in that they offer a mechanism by which up-regulated COX-2 may promote neuronal excitation by suppressing DSE while enhancing conversion of 2-AG to PGE(2) -glycerol ester under pathological conditions.	glyceryl 2-arachidonate	245-249	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	158-163
21564090-8	2011	The results for COX-2, which is often up-regulated under pathological conditions, are of particular note in that they offer a mechanism by which up-regulated COX-2 may promote neuronal excitation by suppressing DSE while enhancing conversion of 2-AG to PGE(2) -glycerol ester under pathological conditions.	pge(2) -glycerol ester	253-275	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-21
21564090-8	2011	The results for COX-2, which is often up-regulated under pathological conditions, are of particular note in that they offer a mechanism by which up-regulated COX-2 may promote neuronal excitation by suppressing DSE while enhancing conversion of 2-AG to PGE(2) -glycerol ester under pathological conditions.	pge(2) -glycerol ester	253-275	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	158-163
21807123-0	2011	The acid sphingomyelinase inhibitors block interferon-alpha-induced serotonin uptake via a COX-2/Akt/ERK/STAT-dependent pathway in T cells.	Serotonin	68-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-96
21926111-0	2011	Colon tumour cells increase PGE(2) by regulating COX-2 and 15-PGDH to promote survival during the microenvironmental stress of glucose deprivation.	Prostaglandins E	28-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-54
21926111-3	2011	The cyclooxygenase (COX)-2/prostaglandin E(2) (PGE(2)) pathway has key roles in colorectal tumorigenesis.	Dinoprostone	27-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-26
21926111-3	2011	The cyclooxygenase (COX)-2/prostaglandin E(2) (PGE(2)) pathway has key roles in colorectal tumorigenesis.	Dinoprostone	47-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-26
21807123-7	2011	The COX-2 inhibitor celecoxib blocked IFN-alpha-induced COX-2 expression, 5-HT uptake and activation of Akt, ERK and STAT.	Celecoxib	20-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
21835194-4	2011	Hexamerization of mPEG-insulin upon H(2)O(2)-mediated oxidation of Co(II) was kinetically and quantitatively analysed by visible spectrometry and size-exclusion HPLC.	monomethoxypolyethylene glycol	18-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-73
21807123-7	2011	The COX-2 inhibitor celecoxib blocked IFN-alpha-induced COX-2 expression, 5-HT uptake and activation of Akt, ERK and STAT.	Celecoxib	20-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-61
21807123-9	2011	D609 also blocked IFN-alpha-induced COX-2 and Akt activation.	tricyclodecane-9-yl-xanthogenate	0-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-41
21835194-4	2011	Hexamerization of mPEG-insulin upon H(2)O(2)-mediated oxidation of Co(II) was kinetically and quantitatively analysed by visible spectrometry and size-exclusion HPLC.	Hydrogen Peroxide	36-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-73
21807123-11	2011	Furthermore, fluoxetine as an acid SMase inhibitor lowered IFN-alpha-induced SMase activity as well as attenuated COX-2, Akt, ERK, and STAT activation.	Fluoxetine	13-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-119
21964530-2	2011	Overexpression of COX-2 or 5-LOX increases levels of PGE-2 and 5-HETE, respectively.	Prostaglandins E	53-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-23
21964530-2	2011	Overexpression of COX-2 or 5-LOX increases levels of PGE-2 and 5-HETE, respectively.	5-hydroxy-6,8,11,14-eicosatetraenoic acid	63-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-23
21777697-3	2011	Pretreatment human umbilical vein endothelial cells (HUVECs) with ZLJ-6 (3, 10 and 30 muM) concentration-dependently decreased TNF-alpha-induced monocyte-endothelial interactions in both static and dynamic conditions whereas no effect was found after pretreatment with the COX-2 inhibitor celecoxib (30 muM), 5-LOX inhibitor zileuton (30 muM) and the combination of them.	ZLJ-6	66-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	273-278
21734230-1	2011	Cyclooxygenase 2 (Cox-2, a rate-limiting enzyme in the conversion of arachidonic acid to prostanoids) has been implicated in several physiological and pathological processes, and it has been reported that polymorphisms in the regulatory region of Cox-2 might influence its expression, contributing to the interindividual susceptibility to cancer.	Arachidonic Acid	69-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-23
21734230-1	2011	Cyclooxygenase 2 (Cox-2, a rate-limiting enzyme in the conversion of arachidonic acid to prostanoids) has been implicated in several physiological and pathological processes, and it has been reported that polymorphisms in the regulatory region of Cox-2 might influence its expression, contributing to the interindividual susceptibility to cancer.	Arachidonic Acid	69-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	247-252
21734230-1	2011	Cyclooxygenase 2 (Cox-2, a rate-limiting enzyme in the conversion of arachidonic acid to prostanoids) has been implicated in several physiological and pathological processes, and it has been reported that polymorphisms in the regulatory region of Cox-2 might influence its expression, contributing to the interindividual susceptibility to cancer.	Prostaglandins	89-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-23
21734230-1	2011	Cyclooxygenase 2 (Cox-2, a rate-limiting enzyme in the conversion of arachidonic acid to prostanoids) has been implicated in several physiological and pathological processes, and it has been reported that polymorphisms in the regulatory region of Cox-2 might influence its expression, contributing to the interindividual susceptibility to cancer.	Prostaglandins	89-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	247-252
21855399-1	2011	The Schiff base ligand, N,N"-bis-(4-isopropylbenzaldimine)-1,2-diaminoethane (L), obtained by the condensation of 4-isopropylbenzaldehyde and 1,2-diaminoethane, has been used to synthesize the complexes of the type [ML(2)X(2)] [M = Co(II), Ni(II) and Zn(II); X = Cl and OAc].	Schiff Bases	4-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	232-238
21855399-1	2011	The Schiff base ligand, N,N"-bis-(4-isopropylbenzaldimine)-1,2-diaminoethane (L), obtained by the condensation of 4-isopropylbenzaldehyde and 1,2-diaminoethane, has been used to synthesize the complexes of the type [ML(2)X(2)] [M = Co(II), Ni(II) and Zn(II); X = Cl and OAc].	n,n"-bis-(4-isopropylbenzaldimine)-1,2-diaminoethane	24-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	232-238
21855399-1	2011	The Schiff base ligand, N,N"-bis-(4-isopropylbenzaldimine)-1,2-diaminoethane (L), obtained by the condensation of 4-isopropylbenzaldehyde and 1,2-diaminoethane, has been used to synthesize the complexes of the type [ML(2)X(2)] [M = Co(II), Ni(II) and Zn(II); X = Cl and OAc].	ethylenediamine	59-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	232-238
21777697-7	2011	Taken together, our results indicated that ZLJ-6 potently inhibited TNF-alpha-induced monocyte-endothelial interactions and adhesion molecule (E-selectin, ICAM-1 and VCAM-1) expression and these effects were mediated by NF-kappaB signaling pathway rather than its primary pharmacological target COX-2 or 5-LOX.	ZLJ-6	43-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	295-300
21743936-4	2011	Mn(II), Co(II), Co(III), Ni(II) and Zn(II) give similar fac structures, alongside the imidazole analogues for Fe(II).	imidazole	86-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	8-14
21743936-4	2011	Mn(II), Co(II), Co(III), Ni(II) and Zn(II) give similar fac structures, alongside the imidazole analogues for Fe(II).	ammonium ferrous sulfate	110-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	8-14
21853186-1	2011	The reaction between pyridine-2-ylmethanol (HL), anhydrous CoCl(2) and NaH afforded polynuclear Co(II) complexes [Co(7)(L)(12)]Cl(2) (1), [Co(6)Na(L)(12)]Cl (2) and [Co(4)Cl(2)(L)(6)] (3), depending on the HL:CoCl(2) ratio set in the reaction.	l)(12)	120-126	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-102
21853186-1	2011	The reaction between pyridine-2-ylmethanol (HL), anhydrous CoCl(2) and NaH afforded polynuclear Co(II) complexes [Co(7)(L)(12)]Cl(2) (1), [Co(6)Na(L)(12)]Cl (2) and [Co(4)Cl(2)(L)(6)] (3), depending on the HL:CoCl(2) ratio set in the reaction.	co(4)cl	166-173	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-102
21853186-1	2011	The reaction between pyridine-2-ylmethanol (HL), anhydrous CoCl(2) and NaH afforded polynuclear Co(II) complexes [Co(7)(L)(12)]Cl(2) (1), [Co(6)Na(L)(12)]Cl (2) and [Co(4)Cl(2)(L)(6)] (3), depending on the HL:CoCl(2) ratio set in the reaction.	cobaltous chloride	59-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-102
21866283-1	2011	The monoanionic N(4)O ligand N-methyl-N,N"-bis(2-pyridylmethyl)ethylenediamine-N"-acetate (mebpena(-)) undergoes oxidative C-N bond cleavage in the presence of Co(II) and O(2).	monoanionic	4-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	160-166
21866283-1	2011	The monoanionic N(4)O ligand N-methyl-N,N"-bis(2-pyridylmethyl)ethylenediamine-N"-acetate (mebpena(-)) undergoes oxidative C-N bond cleavage in the presence of Co(II) and O(2).	n(4)o	16-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	160-166
21866283-1	2011	The monoanionic N(4)O ligand N-methyl-N,N"-bis(2-pyridylmethyl)ethylenediamine-N"-acetate (mebpena(-)) undergoes oxidative C-N bond cleavage in the presence of Co(II) and O(2).	n-methyl-n,n"-bis(2-pyridylmethyl)ethylenediamine-n"-acetate	29-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	160-166
21866283-1	2011	The monoanionic N(4)O ligand N-methyl-N,N"-bis(2-pyridylmethyl)ethylenediamine-N"-acetate (mebpena(-)) undergoes oxidative C-N bond cleavage in the presence of Co(II) and O(2).	mebpena	91-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	160-166
21866283-1	2011	The monoanionic N(4)O ligand N-methyl-N,N"-bis(2-pyridylmethyl)ethylenediamine-N"-acetate (mebpena(-)) undergoes oxidative C-N bond cleavage in the presence of Co(II) and O(2).	Nitrogen	16-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	160-166
21866283-6	2011	DFT calculations support a proposal that [Co(II)(mebpena)](+) reacts with O(2) to form a Co(III)-superoxide complex which can abstract an H atom from a ligand methylene C atom as the initial step towards the observed oxidative C-N bond cleavage.	o(2)	74-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47
21866283-6	2011	DFT calculations support a proposal that [Co(II)(mebpena)](+) reacts with O(2) to form a Co(III)-superoxide complex which can abstract an H atom from a ligand methylene C atom as the initial step towards the observed oxidative C-N bond cleavage.	Superoxides	97-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47
21870003-0	2011	2-(2-Pyridyl) benzimidazole based Co(II) complex as an efficient fluorescent probe for trace level determination of aspartic and glutamic acid in aqueous solution: a displacement approach.	2-(2'-pyridyl)benzimidazole	0-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-40
21870003-0	2011	2-(2-Pyridyl) benzimidazole based Co(II) complex as an efficient fluorescent probe for trace level determination of aspartic and glutamic acid in aqueous solution: a displacement approach.	aspartic	116-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-40
21870003-0	2011	2-(2-Pyridyl) benzimidazole based Co(II) complex as an efficient fluorescent probe for trace level determination of aspartic and glutamic acid in aqueous solution: a displacement approach.	Glutamic Acid	129-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-40
21870003-4	2011	Both aspartic acid and glutamic acid replaces PBI from the coordination sphere of Co(II)-PBI complex resulting appearance of strong fluorescence signal for the released free PBI.	Aspartic Acid	5-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-88
21870003-4	2011	Both aspartic acid and glutamic acid replaces PBI from the coordination sphere of Co(II)-PBI complex resulting appearance of strong fluorescence signal for the released free PBI.	Glutamic Acid	23-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-88
21870003-4	2011	Both aspartic acid and glutamic acid replaces PBI from the coordination sphere of Co(II)-PBI complex resulting appearance of strong fluorescence signal for the released free PBI.	2-(2'-pyridyl)benzimidazole	46-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-88
21870003-4	2011	Both aspartic acid and glutamic acid replaces PBI from the coordination sphere of Co(II)-PBI complex resulting appearance of strong fluorescence signal for the released free PBI.	2-(2'-pyridyl)benzimidazole	89-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-88
21870003-5	2011	The signal response is very fast and the interaction of both the AspA and GluA with the Co(II) is strong enough as evident from their displacement equilibrium constant values, viz.	Aspartic Acid	65-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-94
21870003-5	2011	The signal response is very fast and the interaction of both the AspA and GluA with the Co(II) is strong enough as evident from their displacement equilibrium constant values, viz.	Glutamic Acid	74-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-94
21520926-5	2011	The "redox noninnocence" of Fischer-type carbene ligands is most clearly illustrated at group 9 transition metals in the oxidation state II+ (Co(II), Rh(II), and Ir(II)).	carbene	41-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	142-148
21913670-2	2011	The Co(II) complexes generally adopt a tetrahedral configuration of general formula [(NP2)Co(I)(2)], wherein the two phosphorus donors are bound to the metal center but the central N-donor remains unbound.	co(i)(2)	90-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
21913670-2	2011	The Co(II) complexes generally adopt a tetrahedral configuration of general formula [(NP2)Co(I)(2)], wherein the two phosphorus donors are bound to the metal center but the central N-donor remains unbound.	Phosphorus	117-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
21913670-2	2011	The Co(II) complexes generally adopt a tetrahedral configuration of general formula [(NP2)Co(I)(2)], wherein the two phosphorus donors are bound to the metal center but the central N-donor remains unbound.	Nitrogen	86-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
21913670-4	2011	The Co(II) complex derived from (Bz)NP2 displays dual coordination modes: one in the tetrahedral complex [((Bz)NP2)Co(I)(2)]; and the other in a square pyramidal variant, [((Bz)NP2)Co(I)(2)].	NAD	115-120	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
21913670-4	2011	The Co(II) complex derived from (Bz)NP2 displays dual coordination modes: one in the tetrahedral complex [((Bz)NP2)Co(I)(2)]; and the other in a square pyramidal variant, [((Bz)NP2)Co(I)(2)].	NAD	181-186	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
21752698-0	2011	Spectroscopic and mycological studies of Co(II), Ni(II) and Cu(II) complexes with 4-aminoantipyrine derivative.	Ampyrone	82-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-47
21752698-3	2011	The Schiff"s base ligand forms hexacoordinated complexes having octahedral geometry for Ni(II) and tetragonal geometry for Co(II) and Cu(II) complexes.	schiff"s base	4-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-129
21864977-3	2011	Maximal extraction percentages were obtained for Co(II) (99.8%), Fe(III) (12.7%) and Ni(II) (3.17%) when the ATPS was composed of PEO1500 + (NH(4))(2)SO(4) + H(2)O containing 1.4 mmol of KSCN at pH 4.0, providing separation factors as high as S(Co, Fe) = 3440 and S(Co, Ni) = 15,300.	atps	109-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-55
21864977-5	2011	The proposed technique was shown to be efficient in the extraction of Co(II) and Fe(III), with large viability for the selective separation of Co(II) and Fe(III) ions in the presence of Ni(II).	ferric sulfate	81-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	143-149
21864977-5	2011	The proposed technique was shown to be efficient in the extraction of Co(II) and Fe(III), with large viability for the selective separation of Co(II) and Fe(III) ions in the presence of Ni(II).	ferric sulfate	154-161	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-76
21864977-5	2011	The proposed technique was shown to be efficient in the extraction of Co(II) and Fe(III), with large viability for the selective separation of Co(II) and Fe(III) ions in the presence of Ni(II).	Nickel(2+)	186-192	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-76
21864977-5	2011	The proposed technique was shown to be efficient in the extraction of Co(II) and Fe(III), with large viability for the selective separation of Co(II) and Fe(III) ions in the presence of Ni(II).	Nickel(2+)	186-192	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	143-149
22051946-1	2011	The crystal structure of the cobalt(II) carbonate-based compound cobalt(II) dicarbonate trisodium chloride, Co(CO(3))(2)Na(3)Cl, grown from a water-ethanol mixture, exhibits a three-dimensional network of corner-sharing {Co(4)(mu(3)-CO(3))(4)} tetrahedral building blocks, in which the Co(II) centres define a pyrochlore lattice and reside in a slightly distorted octahedral Co(O-CO(2))(6) environment.	COBALT CARBONATE	29-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	286-292
21853186-0	2011	Synthesis, characterization, and single-molecule metamagnetism of new Co(II) polynuclear complexes of pyridine-2-ylmethanol.	2-PYRIDINEMETHANOL	102-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-76
21853186-1	2011	The reaction between pyridine-2-ylmethanol (HL), anhydrous CoCl(2) and NaH afforded polynuclear Co(II) complexes [Co(7)(L)(12)]Cl(2) (1), [Co(6)Na(L)(12)]Cl (2) and [Co(4)Cl(2)(L)(6)] (3), depending on the HL:CoCl(2) ratio set in the reaction.	2-PYRIDINEMETHANOL	21-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-102
21853186-1	2011	The reaction between pyridine-2-ylmethanol (HL), anhydrous CoCl(2) and NaH afforded polynuclear Co(II) complexes [Co(7)(L)(12)]Cl(2) (1), [Co(6)Na(L)(12)]Cl (2) and [Co(4)Cl(2)(L)(6)] (3), depending on the HL:CoCl(2) ratio set in the reaction.	cocl	59-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-102
21853186-1	2011	The reaction between pyridine-2-ylmethanol (HL), anhydrous CoCl(2) and NaH afforded polynuclear Co(II) complexes [Co(7)(L)(12)]Cl(2) (1), [Co(6)Na(L)(12)]Cl (2) and [Co(4)Cl(2)(L)(6)] (3), depending on the HL:CoCl(2) ratio set in the reaction.	sodium bisulfide	71-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-102
21853186-1	2011	The reaction between pyridine-2-ylmethanol (HL), anhydrous CoCl(2) and NaH afforded polynuclear Co(II) complexes [Co(7)(L)(12)]Cl(2) (1), [Co(6)Na(L)(12)]Cl (2) and [Co(4)Cl(2)(L)(6)] (3), depending on the HL:CoCl(2) ratio set in the reaction.	co(7)	114-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-102
21853186-1	2011	The reaction between pyridine-2-ylmethanol (HL), anhydrous CoCl(2) and NaH afforded polynuclear Co(II) complexes [Co(7)(L)(12)]Cl(2) (1), [Co(6)Na(L)(12)]Cl (2) and [Co(4)Cl(2)(L)(6)] (3), depending on the HL:CoCl(2) ratio set in the reaction.	Chlorine	61-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-102
21853186-1	2011	The reaction between pyridine-2-ylmethanol (HL), anhydrous CoCl(2) and NaH afforded polynuclear Co(II) complexes [Co(7)(L)(12)]Cl(2) (1), [Co(6)Na(L)(12)]Cl (2) and [Co(4)Cl(2)(L)(6)] (3), depending on the HL:CoCl(2) ratio set in the reaction.	co(6)	139-144	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-102
21887436-0	2011	Co(II), Mn(II) and Cu(II)-directed coordination polymers with mixed tetrazolate-dicarboxylate heterobridges exhibiting spin-canted, spin-frustrated antiferromagnetism and a slight spin-flop transition.	cu(ii)	19-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
21887436-0	2011	Co(II), Mn(II) and Cu(II)-directed coordination polymers with mixed tetrazolate-dicarboxylate heterobridges exhibiting spin-canted, spin-frustrated antiferromagnetism and a slight spin-flop transition.	Polymers	48-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
21887436-0	2011	Co(II), Mn(II) and Cu(II)-directed coordination polymers with mixed tetrazolate-dicarboxylate heterobridges exhibiting spin-canted, spin-frustrated antiferromagnetism and a slight spin-flop transition.	tetrazolate	68-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
21887436-0	2011	Co(II), Mn(II) and Cu(II)-directed coordination polymers with mixed tetrazolate-dicarboxylate heterobridges exhibiting spin-canted, spin-frustrated antiferromagnetism and a slight spin-flop transition.	malonic acid	80-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
21894333-0	2011	A temperature-dependent order-disorder and crystallographic phase transition in a 0D Fe(II) spin crossover compound and its non-spin crossover Co(II) isomorph.	ammonium ferrous sulfate	85-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	143-149
21882826-1	2011	We fabricated a vertically and unidirectionally oriented metal coordinated alpha-helical peptide monolayer, Leu(2)Ala(Pyri)(Co(II))Leu(6)Ala(4-Pyri)(Co(II))Leu(6), by stepwise polymerization on a mixed self-assembled monolayer consisting of amino-alkanethiol, dialkyl disulfide, and ferrocenyl alkanethiol acted as a photoresponsive electron donor.	Metals	57-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	124-130
21882826-1	2011	We fabricated a vertically and unidirectionally oriented metal coordinated alpha-helical peptide monolayer, Leu(2)Ala(Pyri)(Co(II))Leu(6)Ala(4-Pyri)(Co(II))Leu(6), by stepwise polymerization on a mixed self-assembled monolayer consisting of amino-alkanethiol, dialkyl disulfide, and ferrocenyl alkanethiol acted as a photoresponsive electron donor.	Metals	57-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	149-155
21882826-1	2011	We fabricated a vertically and unidirectionally oriented metal coordinated alpha-helical peptide monolayer, Leu(2)Ala(Pyri)(Co(II))Leu(6)Ala(4-Pyri)(Co(II))Leu(6), by stepwise polymerization on a mixed self-assembled monolayer consisting of amino-alkanethiol, dialkyl disulfide, and ferrocenyl alkanethiol acted as a photoresponsive electron donor.	ala(pyri)	114-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	124-130
21882826-1	2011	We fabricated a vertically and unidirectionally oriented metal coordinated alpha-helical peptide monolayer, Leu(2)Ala(Pyri)(Co(II))Leu(6)Ala(4-Pyri)(Co(II))Leu(6), by stepwise polymerization on a mixed self-assembled monolayer consisting of amino-alkanethiol, dialkyl disulfide, and ferrocenyl alkanethiol acted as a photoresponsive electron donor.	ala(pyri)	114-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	149-155
21890358-3	2011	Molecular modeling studies for 9f showed that the SO(2)NH(2) group assumes a position within the secondary pocket of the COX-2 active site wherein the SO(2)NH(2) oxygen atom is hydrogen bonded to the H90 residue (2.90A), the SO(2)NH(2) nitrogen atom forms a hydrogen bond with L352 (N O=2.80A), and the acetyl group is positioned in the vicinity of the S530 residue where the acetyl oxygen atom undergoes hydrogen bonding to L531 (2.99A).	Oxygen	162-168	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-126
21890358-3	2011	Molecular modeling studies for 9f showed that the SO(2)NH(2) group assumes a position within the secondary pocket of the COX-2 active site wherein the SO(2)NH(2) oxygen atom is hydrogen bonded to the H90 residue (2.90A), the SO(2)NH(2) nitrogen atom forms a hydrogen bond with L352 (N O=2.80A), and the acetyl group is positioned in the vicinity of the S530 residue where the acetyl oxygen atom undergoes hydrogen bonding to L531 (2.99A).	Hydrogen	177-185	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-126
21890358-3	2011	Molecular modeling studies for 9f showed that the SO(2)NH(2) group assumes a position within the secondary pocket of the COX-2 active site wherein the SO(2)NH(2) oxygen atom is hydrogen bonded to the H90 residue (2.90A), the SO(2)NH(2) nitrogen atom forms a hydrogen bond with L352 (N O=2.80A), and the acetyl group is positioned in the vicinity of the S530 residue where the acetyl oxygen atom undergoes hydrogen bonding to L531 (2.99A).	Nitrogen	236-244	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-126
21890358-3	2011	Molecular modeling studies for 9f showed that the SO(2)NH(2) group assumes a position within the secondary pocket of the COX-2 active site wherein the SO(2)NH(2) oxygen atom is hydrogen bonded to the H90 residue (2.90A), the SO(2)NH(2) nitrogen atom forms a hydrogen bond with L352 (N O=2.80A), and the acetyl group is positioned in the vicinity of the S530 residue where the acetyl oxygen atom undergoes hydrogen bonding to L531 (2.99A).	Hydrogen	258-266	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-126
21890358-3	2011	Molecular modeling studies for 9f showed that the SO(2)NH(2) group assumes a position within the secondary pocket of the COX-2 active site wherein the SO(2)NH(2) oxygen atom is hydrogen bonded to the H90 residue (2.90A), the SO(2)NH(2) nitrogen atom forms a hydrogen bond with L352 (N O=2.80A), and the acetyl group is positioned in the vicinity of the S530 residue where the acetyl oxygen atom undergoes hydrogen bonding to L531 (2.99A).	Oxygen	383-389	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-126
21890358-3	2011	Molecular modeling studies for 9f showed that the SO(2)NH(2) group assumes a position within the secondary pocket of the COX-2 active site wherein the SO(2)NH(2) oxygen atom is hydrogen bonded to the H90 residue (2.90A), the SO(2)NH(2) nitrogen atom forms a hydrogen bond with L352 (N O=2.80A), and the acetyl group is positioned in the vicinity of the S530 residue where the acetyl oxygen atom undergoes hydrogen bonding to L531 (2.99A).	Hydrogen	258-266	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-126
21757398-4	2011	Electronic spectral data and magnetic moment values revealed that polymer metal complexes of Mn(II), Co(II) and Ni(II) show an octahedral geometry while Cu(II) and Zn(II) show distorted octahedral and tetrahedral geometry respectively.	polymer metal	66-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-107
21763185-3	2011	The IR data reflect the bidentate mode of 2TMPACT towards the mononuclear complex [Mn(II)] even its tetradentate in binuclear complexes [Co(II) and Cu(II)].	Manganese(2+)	83-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-143
21835544-2	2011	The selectivity order of the resin towards some metal ions follows the order Pb(II) &gt; Cu(II)&gt; Zn(II), Ni(II), Co(II).	Metals	48-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-122
21902213-3	2011	Described here are first-of-a-kind studies of COX-2-catalyzed oxidation of the substrate analogue linoleic acid.	Linoleic Acid	98-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
21899323-1	2011	Bis(imino)pyridine pincer ligands in conjunction with two isothiocyanate ligands have been used to prepare two mononuclear Co(II) complexes.	bis(imino)pyridine	0-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-129
21899323-1	2011	Bis(imino)pyridine pincer ligands in conjunction with two isothiocyanate ligands have been used to prepare two mononuclear Co(II) complexes.	isothiocyanic acid	58-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-129
22065711-1	2011	The asymmetric unit of the title compound, Cs(2)[Co(CH(4)O(6)P(2))(2)(H(2)O)(2)], is comprised of one bidentate methyl-enediphospho-nate ligand and one water mol-ecule which are coordinated to the Co(II) atom, as well as a caesium counter-cation.	Carbon Disulfide	43-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	197-203
21870825-0	2011	Highly asymmetric intramolecular cyclopropanation of acceptor-substituted diazoacetates by Co(II)-based metalloradical catalysis: iterative approach for development of new-generation catalysts.	diazoacetates	74-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-96
21870825-1	2011	3,5-Di(t)Bu-QingPhyrin, a new D(2)-symmetric chiral porphyrin derived from a chiral cyclopropanecarboxamide containing two contiguous stereocenters, has been developed using an iterative approach based on Co(II)-catalyzed asymmetric cyclopropanation of alkenes.	3,5-di(t)bu-qingphyrin	0-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	205-210
21870825-1	2011	3,5-Di(t)Bu-QingPhyrin, a new D(2)-symmetric chiral porphyrin derived from a chiral cyclopropanecarboxamide containing two contiguous stereocenters, has been developed using an iterative approach based on Co(II)-catalyzed asymmetric cyclopropanation of alkenes.	Porphyrins	52-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	205-210
21870825-2	2011	The Co(II) complex of 3,5-Di(t)Bu-QingPhyrin, [Co(P2)], has proved to be a general and effective catalyst for asymmetric intramolecular cyclopropanation of various allylic diazoacetates (especially including those with alpha-acceptor substituents) in high yields with excellent stereoselectivities.	3,5-di(t)bu-qingphyrin	22-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
21870825-2	2011	The Co(II) complex of 3,5-Di(t)Bu-QingPhyrin, [Co(P2)], has proved to be a general and effective catalyst for asymmetric intramolecular cyclopropanation of various allylic diazoacetates (especially including those with alpha-acceptor substituents) in high yields with excellent stereoselectivities.	co(p2)	47-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
21870825-2	2011	The Co(II) complex of 3,5-Di(t)Bu-QingPhyrin, [Co(P2)], has proved to be a general and effective catalyst for asymmetric intramolecular cyclopropanation of various allylic diazoacetates (especially including those with alpha-acceptor substituents) in high yields with excellent stereoselectivities.	diazoacetates	172-185	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
22065711-1	2011	The asymmetric unit of the title compound, Cs(2)[Co(CH(4)O(6)P(2))(2)(H(2)O)(2)], is comprised of one bidentate methyl-enediphospho-nate ligand and one water mol-ecule which are coordinated to the Co(II) atom, as well as a caesium counter-cation.	co(ch(4)o(6)p(2))	49-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	197-203
22058721-2	2011	The Co(II) atom is chelated by the three taurinate ligands in a distorted octa-hedral geometry and in a facial manner.	taurinate	41-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
22058721-2	2011	The Co(II) atom is chelated by the three taurinate ligands in a distorted octa-hedral geometry and in a facial manner.	hedral	79-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
22058722-1	2011	In the title compound, Na(2)[Co(CH(4)O(6)P(2))(2)(H(2)O)(2)] 2H(2)O, the asymmetric unit is composed of one methyl-enediphospho-nate ligand and one water mol-ecule, which both are coordinated to a Co(II) atom, as well as a non-coordinated water mol-ecule and a sodium cation.	sodium sulfide	23-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	197-203
22058722-1	2011	In the title compound, Na(2)[Co(CH(4)O(6)P(2))(2)(H(2)O)(2)] 2H(2)O, the asymmetric unit is composed of one methyl-enediphospho-nate ligand and one water mol-ecule, which both are coordinated to a Co(II) atom, as well as a non-coordinated water mol-ecule and a sodium cation.	co(ch(4)o(6)p(2))	29-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	197-203
21745460-5	2011	We discovered FK881, a specific COX-1 inhibitor which exhibits a 650-fold ratio for human whole blood COX-1/COX-2 and rats in vivo.	3-methoxy-1,5-bis(4-methoxyphenyl)-1H-1,2,4-triazole	14-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-113
21361874-8	2011	The bcl-2, p53 and cox-2 genes in both cell lines treated with ASA seem to exhibit different patterns of expression.	Aspirin	63-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-24
21993002-2	2011	COX-2 inhibitor celecoxib displays inhibitory effects in pancreatic cancer cell growth.	Celecoxib	16-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
21843935-0	2011	Inhibition of COX-1 activity and COX-2 expression by 3-(4"-geranyloxy-3"-methoxyphenyl)-2-trans propenoic acid and its semi-synthetic derivatives.	3-(4'-geranyloxy-3'-methoxyphenyl)-2-trans-propenoic acid	53-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-38
21843935-2	2011	Aim of this study was to characterize the effects of 3-(4"-geranyl-3"-methoxy)phenyl-2-trans propenoic acid and its selected semi-synthetic analogues, on COX-2 expression and activity, and on COX-1 activity, in purified systems or in whole cell systems.	3-(4"-geranyl-3"-methoxy)phenyl-2-trans propenoic acid	53-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	154-159
21843935-4	2011	COX-2 expression was completely suppressed when monocytes were incubated with 100 muM of 3-(4"-geranyl-3"-methoxy)phenyl-2-trans propenoic acid (1) or 3-(4"-isopentenyloxy)phenyl-2-trans propenoic acid (4).	3-(4"-geranyl-3"-methoxy)phenyl-2-trans propenoic acid	89-143	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
21843935-4	2011	COX-2 expression was completely suppressed when monocytes were incubated with 100 muM of 3-(4"-geranyl-3"-methoxy)phenyl-2-trans propenoic acid (1) or 3-(4"-isopentenyloxy)phenyl-2-trans propenoic acid (4).	3-(4"-isopentenyloxy)phenyl-2-trans propenoic acid	151-201	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
21896649-3	2011	In this issue of the journal (beginning on page 1580), Sabichi and colleagues report the first phase II randomized controlled trial of the COX-2 inhibitor celecoxib in bladder cancer.	Celecoxib	155-164	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-144
21868755-1	2011	Celecoxib is a COX-2 inhibitor that reduces the risk of colon cancer.	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-20
23733687-5	2011	In addition to high levels of expression of the "constitutive" rate-limiting enzyme responsible for prostanoid production, COX-1, the "inducible" isoform of cyclooxygenase, COX-2, is also constitutively expressed in the kidney and is highly regulated in response to alterations in intravascular volume.	Prostaglandins	100-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	173-178
21710489-12	2011	Suppression entails cell-contact-dependent COX-2 induction resulting in direct Th17 inhibition by PGE2 via EP4.	Dinoprostone	98-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
21361874-4	2011	The mechanism of action of different concentrations of ASA were compared in K562 (non-MDR) and Lucena (MDR) cells by analysing cell viability, apoptosis and necrosis, intracellular ROS (reactive oxygen species) formation and bcl-2, p53 and cox-2 gene expression.	Aspirin	55-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	240-245
21939359-9	2011	In addition, the expression analysis of genes involved in apoptosis and inflammation revealed significant downregulation of Bcl-2, COX-2, and IL-1beta on treatment with eugenol.	Eugenol	169-176	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-136
21570918-6	2011	NS-398, a selective COX-2 inhibitor, effectively diminished S100B mediated activity of AChR-specific antibody secreting splenocytes.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	0-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-25
21905970-1	2011	OBJECTIVE: To further assess the clinically active dose range of etoricoxib, a COX-2 selective inhibitor, in rheumatoid arthritis (RA).	Etoricoxib	65-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-84
22089605-1	2011	BACKGROUND &amp; OBJECTIVES: Recently, a significantly higher ratio of nucleotide changes in the mtDNA genes: COII, ATPase 6, ATPase 8, ND2, ND3, ND4, and ND5 was reported in spermatozoa from populations of infertile Indian men, compared suggesting that screening for mtDNA mutations could provide insight into the aetiology of male infertility.	Adenosine Monophosphate	12-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-114
24250402-7	2011	However, the recent market removal of some COXIBs such as rofecoxib due to its adverse cardiovascular side effects clearly encourages the researchers to explore and evaluate alternative templates with COX-2 inhibitory activity.	rofecoxib	58-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	201-206
21946257-10	2011	The antiviral drug valganciclovir and the specific COX-2 inhibitor celecoxib prevented HCMV replication in vitro and inhibited PGE2 production and reduced medulloblastoma tumor cell growth both in vitro and in vivo.	Celecoxib	67-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-56
21946257-10	2011	The antiviral drug valganciclovir and the specific COX-2 inhibitor celecoxib prevented HCMV replication in vitro and inhibited PGE2 production and reduced medulloblastoma tumor cell growth both in vitro and in vivo.	Dinoprostone	127-131	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-56
21796789-7	2011	Metal ions, i.e. Co(II), Cu(II), Ni(II), Al(III), and Fe(III), as models were injected into the present TRDC system.	Metals	0-5	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-23
21796789-9	2011	The elution times of the metal ions were examined based on their absorption behavior; Co(II), Ni(II), Al(III), Fe(III), and Cu(II) were eluted in this order over the elution times of 4.7-6.8 min.	Metals	25-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-92
21763744-5	2011	COX-2 inhibitor Celecoxib reduced self renewal capacity and increased apoptosis of both control and IL-1beta treated CSCs.	Celecoxib	16-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
21961478-4	2011	Most of the miRNA target genes that showed altered expression could be classified as apoptotic genes and were up-regulated by PUFA or temozolomide treatment, while similar treatments resulted in repression of the corresponding mRNAs, such as cox2, irs1, irs2, ccnd1, itgb3, bcl2, sirt1, tp53inp1 and k-ras.	Fatty Acids, Unsaturated	126-130	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	242-246
21807015-4	2011	Our results showed that among the tested molecules, all sensitizers specifically prevent the production of PMA/LPS-induced COX-2 metabolites (PGE(2,) TxB(2) and PGD(2)), eugenol and cinnamaldehyde inhibiting also the production of IL-1beta and TNF-alpha.	Tetradecanoylphorbol Acetate	107-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-128
21807015-4	2011	Our results showed that among the tested molecules, all sensitizers specifically prevent the production of PMA/LPS-induced COX-2 metabolites (PGE(2,) TxB(2) and PGD(2)), eugenol and cinnamaldehyde inhibiting also the production of IL-1beta and TNF-alpha.	Prostaglandins E	142-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-128
21961478-4	2011	Most of the miRNA target genes that showed altered expression could be classified as apoptotic genes and were up-regulated by PUFA or temozolomide treatment, while similar treatments resulted in repression of the corresponding mRNAs, such as cox2, irs1, irs2, ccnd1, itgb3, bcl2, sirt1, tp53inp1 and k-ras.	Temozolomide	134-146	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	242-246
22039321-7	2011	Treatment with NO-ASA dose-dependently accelerated colonic healing followed by a rise in plasma NO(x) content and CBF, suppression of MPO and downregulation of COX-2, iNOS, IL-1beta and TNF-alpha mRNAs.	Aspirin	18-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	160-165
21932236-4	2011	In situ chelation of CoCl(2) and proline (1:2) is proposed to promote the reaction through a six-membered Zimmermann-Traxler type transition state involving the positioning of proline-enamine and the aldehyde through chelation to Co(II).	cobaltous chloride	21-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	230-236
21932236-4	2011	In situ chelation of CoCl(2) and proline (1:2) is proposed to promote the reaction through a six-membered Zimmermann-Traxler type transition state involving the positioning of proline-enamine and the aldehyde through chelation to Co(II).	Proline	33-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	230-236
21932236-4	2011	In situ chelation of CoCl(2) and proline (1:2) is proposed to promote the reaction through a six-membered Zimmermann-Traxler type transition state involving the positioning of proline-enamine and the aldehyde through chelation to Co(II).	proline-enamine	176-191	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	230-236
21932236-4	2011	In situ chelation of CoCl(2) and proline (1:2) is proposed to promote the reaction through a six-membered Zimmermann-Traxler type transition state involving the positioning of proline-enamine and the aldehyde through chelation to Co(II).	Aldehydes	200-208	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	230-236
21807203-2	2011	The method exploited the Co(II)-catalysed CL reaction of luminol with hydrogen peroxide in alkaline medium.	Luminol	57-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-30
21807508-0	2011	Design and synthesis of a biotinylated probe of COX-2 inhibitor nimesulide analog JCC76.	nimesulide	64-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-53
21807508-0	2011	Design and synthesis of a biotinylated probe of COX-2 inhibitor nimesulide analog JCC76.	cyclohexanecarboxylic acid (3-(2,5-dimethylbenzyloxy)-4-(methanesulfonylmethylamino)phenyl)amide	82-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-53
21807508-1	2011	JCC76 is a derivative of cyclooxygenase-2(COX-2) selective inhibitor nimesulide and exhibits potent anti-breast cancer activity.	cyclohexanecarboxylic acid (3-(2,5-dimethylbenzyloxy)-4-(methanesulfonylmethylamino)phenyl)amide	0-5	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47
21807508-1	2011	JCC76 is a derivative of cyclooxygenase-2(COX-2) selective inhibitor nimesulide and exhibits potent anti-breast cancer activity.	nimesulide	69-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47
21796325-0	2011	Interaction of Co(II), Ni(II) and Cu(II) with dibenzo-substituted macrocyclic ligands incorporating both symmetrically and unsymmetrically arranged N, O and S donors.	dibenzo	46-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-21
21807203-2	2011	The method exploited the Co(II)-catalysed CL reaction of luminol with hydrogen peroxide in alkaline medium.	Hydrogen Peroxide	70-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-30
21796325-4	2011	The interaction of Co(II), Ni(II) and Cu(II) with the unsymmetric macrocycle series has been investigated by potentiometric (pH) titration in 95% methanol; X-ray structures of two nickel and three copper complexes of these ligands, each exhibiting 1:1 (M:L) ratios, have been obtained.	Methanol	146-154	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-25
21695713-1	2011	A series of Cu(II), Co(II), Pt(II) and Zn(II) coordination compounds has been prepared by the reaction of the metal chlorides with pyrazine-2-carboxylic acid, pyridine-2-carboxylic acid, imidazole-4-carboxylic acid, benzimidazole-2-carboxylic acid and 1-methylimidazole-2-carboxylic acid.	metal chlorides	110-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-26
21796325-4	2011	The interaction of Co(II), Ni(II) and Cu(II) with the unsymmetric macrocycle series has been investigated by potentiometric (pH) titration in 95% methanol; X-ray structures of two nickel and three copper complexes of these ligands, each exhibiting 1:1 (M:L) ratios, have been obtained.	Nickel	180-186	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-25
21796325-4	2011	The interaction of Co(II), Ni(II) and Cu(II) with the unsymmetric macrocycle series has been investigated by potentiometric (pH) titration in 95% methanol; X-ray structures of two nickel and three copper complexes of these ligands, each exhibiting 1:1 (M:L) ratios, have been obtained.	Copper	197-203	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-25
21664353-8	2011	Several genes, including interferon regulatory factor 1 (IRF1) interleukin-6 (IL-6) and prostaglandin-endoperoxide synthase 2 (COX-2) were induced in CAFs during co-culture.	cafs	150-154	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	127-132
21664353-11	2011	A further proof was achieved by DEX inhibition for IL1-beta-stimulated IL-6 and COX-2 gene expression.	Dexamethasone	32-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-85
22065723-1	2011	In the crystal structure of the title compound, [CoCl(2)(C(15)H(17)Cl(2)N(3)O)(4)], the Co(II) cation lies on an inversion center and has a slightly distorted octa-hedral coordination geometry.	cobaltous chloride	49-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-93
21695713-1	2011	A series of Cu(II), Co(II), Pt(II) and Zn(II) coordination compounds has been prepared by the reaction of the metal chlorides with pyrazine-2-carboxylic acid, pyridine-2-carboxylic acid, imidazole-4-carboxylic acid, benzimidazole-2-carboxylic acid and 1-methylimidazole-2-carboxylic acid.	pyrazinoic acid	131-157	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-26
21695713-1	2011	A series of Cu(II), Co(II), Pt(II) and Zn(II) coordination compounds has been prepared by the reaction of the metal chlorides with pyrazine-2-carboxylic acid, pyridine-2-carboxylic acid, imidazole-4-carboxylic acid, benzimidazole-2-carboxylic acid and 1-methylimidazole-2-carboxylic acid.	1H-Imidazole-4-carboxylic acid	187-214	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-26
21695713-1	2011	A series of Cu(II), Co(II), Pt(II) and Zn(II) coordination compounds has been prepared by the reaction of the metal chlorides with pyrazine-2-carboxylic acid, pyridine-2-carboxylic acid, imidazole-4-carboxylic acid, benzimidazole-2-carboxylic acid and 1-methylimidazole-2-carboxylic acid.	1H-Benzimidazole-2-carboxylic acid	216-247	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-26
21695713-1	2011	A series of Cu(II), Co(II), Pt(II) and Zn(II) coordination compounds has been prepared by the reaction of the metal chlorides with pyrazine-2-carboxylic acid, pyridine-2-carboxylic acid, imidazole-4-carboxylic acid, benzimidazole-2-carboxylic acid and 1-methylimidazole-2-carboxylic acid.	1-Methyl-1H-imidazole-2-carboxylic acid	252-287	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-26
21470077-1	2011	We examined the role of mitogen-activated protein kinase (MAPK) signaling pathways in crystalline silica-induced expression of cyclooxygenase (COX)-2, an important mediator of airway inflammation, in A549 human lung epithelial cells.	Silicon Dioxide	98-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	127-149
21620964-2	2011	Excessive ROS induce expression of inflammatory mediators, such as iNOS and COX2.	Reactive Oxygen Species	10-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-80
21830840-1	2011	BACKGROUND: Naproxen, ibuprofen and diclofenac are frequently used as comparators in randomized controlled trials (RCTs) on the safety and efficacy of cyclooxygenase (COX)-2 inhibitors.	Naproxen	12-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-173
21830840-1	2011	BACKGROUND: Naproxen, ibuprofen and diclofenac are frequently used as comparators in randomized controlled trials (RCTs) on the safety and efficacy of cyclooxygenase (COX)-2 inhibitors.	Diclofenac	36-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-173
21830840-15	2011	In due course, the contrasts between DDDs of COX-2 inhibitors and non-selective NSAIDs converged, both in rofecoxib and celecoxib RCTs; therefore, doses have become more comparable in recent years because of differences in steepness of two decreasing dose trends in the case of celecoxib, and opposing dose trends in the case of rofecoxib.	rofecoxib	106-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-50
21714592-5	2011	The classification in this review includes COX-2 inhibitors based on five- and six-membered heterocycles, benzoheterocycles (e.g., benzopyrans, benzopyranones, indoles and quinolines), quinones, chalcones, natural products and miscellaneous.	Quinolines	172-182	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
21714592-5	2011	The classification in this review includes COX-2 inhibitors based on five- and six-membered heterocycles, benzoheterocycles (e.g., benzopyrans, benzopyranones, indoles and quinolines), quinones, chalcones, natural products and miscellaneous.	Quinones	185-193	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
21714592-5	2011	The classification in this review includes COX-2 inhibitors based on five- and six-membered heterocycles, benzoheterocycles (e.g., benzopyrans, benzopyranones, indoles and quinolines), quinones, chalcones, natural products and miscellaneous.	Chalcones	195-204	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
21879102-5	2011	In mammalian cells, salicylic acid demonstrates several bioactivities that are potentially disease-preventative, including the inhibition of production of potentially neoplastic prostaglandins, which arise from the COX-2 mediated catalysis of arachidonic acid.	Salicylic Acid	20-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	215-220
21879102-5	2011	In mammalian cells, salicylic acid demonstrates several bioactivities that are potentially disease-preventative, including the inhibition of production of potentially neoplastic prostaglandins, which arise from the COX-2 mediated catalysis of arachidonic acid.	Prostaglandins	178-192	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	215-220
21879102-5	2011	In mammalian cells, salicylic acid demonstrates several bioactivities that are potentially disease-preventative, including the inhibition of production of potentially neoplastic prostaglandins, which arise from the COX-2 mediated catalysis of arachidonic acid.	Arachidonic Acid	243-259	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	215-220
21632278-0	2011	Spectral, structural elucidation and coordination abilities of Co(II) and Mn(II) coordination entities of 2,6,11,15-tetraoxa-9,17-diaza-1,7,10,16-(1,2)-tetrabenzenacyclooctadecaphan-8,17-diene.	2,6,11,15-tetraoxa-9,17-diaza-1,7,10,16-(1,2)-tetrabenzenacyclooctadecaphan-8,17-diene	106-192	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-69
21470077-2	2011	The levels of COX-2 mRNA increased after a 30-min exposure, and COX-2 protein increased after a 2-h exposure to crystalline silica.	Silicon Dioxide	124-130	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-69
21470077-6	2011	COX-2 expression was markedly suppressed by treatment with the p38 inhibitor, SB203580, and mildly suppressed by the MAPK/ERK kinase inhibitor, U0126.	SB 203580	78-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
21470077-6	2011	COX-2 expression was markedly suppressed by treatment with the p38 inhibitor, SB203580, and mildly suppressed by the MAPK/ERK kinase inhibitor, U0126.	U 0126	144-149	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
21470077-7	2011	Treatment with the nuclear factor-kappaB (NF-kappaB) inhibitor, BAY11-7082, markedly suppressed silica-induced COX-2 expression.	3-(4-methylphenylsulfonyl)-2-propenenitrile	64-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	111-116
21470077-7	2011	Treatment with the nuclear factor-kappaB (NF-kappaB) inhibitor, BAY11-7082, markedly suppressed silica-induced COX-2 expression.	Silicon Dioxide	96-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	111-116
21470077-8	2011	These results show that crystalline silica exposure induces COX-2 expression in A549 cells in a manner that is dependent on the MAPK and NF-kappaB pathways.	Silicon Dioxide	36-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-65
22121779-9	2011	Metal ions Co(II) and Ni(II) can mediate RT-HSA interaction, making the binding of the drug to protein stronger, which indicates that Co(II) and Ni(II) can enhance rhaponticin"s medical efficacy under physiological conditions.	Metals	0-5	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-17
21725556-2	2011	Its strong binding ability to Co(II) and then to Ni(II) or Cu(II) in the presence of hexafluoroacetylacetonate (hfac(-)), forming new mono- and dinuclear complexes 1-3, is described.	Nickel(2+)	49-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-36
22121779-9	2011	Metal ions Co(II) and Ni(II) can mediate RT-HSA interaction, making the binding of the drug to protein stronger, which indicates that Co(II) and Ni(II) can enhance rhaponticin"s medical efficacy under physiological conditions.	Metals	0-5	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-140
22121779-9	2011	Metal ions Co(II) and Ni(II) can mediate RT-HSA interaction, making the binding of the drug to protein stronger, which indicates that Co(II) and Ni(II) can enhance rhaponticin"s medical efficacy under physiological conditions.	Nickel(2+)	22-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-140
22121779-9	2011	Metal ions Co(II) and Ni(II) can mediate RT-HSA interaction, making the binding of the drug to protein stronger, which indicates that Co(II) and Ni(II) can enhance rhaponticin"s medical efficacy under physiological conditions.	Nickel(2+)	145-151	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-17
21725556-2	2011	Its strong binding ability to Co(II) and then to Ni(II) or Cu(II) in the presence of hexafluoroacetylacetonate (hfac(-)), forming new mono- and dinuclear complexes 1-3, is described.	cu(ii)	59-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-36
21725556-2	2011	Its strong binding ability to Co(II) and then to Ni(II) or Cu(II) in the presence of hexafluoroacetylacetonate (hfac(-)), forming new mono- and dinuclear complexes 1-3, is described.	hexafluoroacetylacetonate	85-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-36
21727971-0	2011	Co-ligand-directed structural and magnetic diversities in an anisotropic Co(II)-triazolate system.	triazolate	80-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-78
21692158-1	2011	A new spin on polymers: the title cations comprise low-spin Co(II) centers with neutral bis(imino)pyridine chelating ligands.	Polymers	14-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-65
21612864-1	2011	In this study, Ca-montmorillonite (Ca-Mt) modified with Bi(3+) was used as a novel adsorbent for the sorption of Co(II) from aqueous solutions.	ca-montmorillonite	15-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-119
21720639-0	2011	Structural evolution and magnetic properties of Co(II) coordination polymers varied from 1D to 3D constructed by 1,4-bis(1,2,4-triazol-1-ylmethyl)benzene.	Polymers	68-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-53
21720639-0	2011	Structural evolution and magnetic properties of Co(II) coordination polymers varied from 1D to 3D constructed by 1,4-bis(1,2,4-triazol-1-ylmethyl)benzene.	1,4-Bis((1H-1,2,4-triazol-1-yl)methyl)benzene	113-153	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-53
21720639-4	2011	The Co(II) ions are bridged by double mu(2)-btx to form Co(2)-btx(2) rings, which were further connected into 1D chains by sharing the Co(II) ions of the rings.	(2)-btx	40-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
21720639-4	2011	The Co(II) ions are bridged by double mu(2)-btx to form Co(2)-btx(2) rings, which were further connected into 1D chains by sharing the Co(II) ions of the rings.	co(2)-btx	56-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
21752640-2	2011	Interesting data have been obtained for 2a, which shows a selective COX-2 inhibition (albeit not as strong as Vioxx itself) exhibiting reduced hERG activity compare to the parent sulfone Vioxx (1).	rofecoxib	187-192	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-73
21612864-1	2011	In this study, Ca-montmorillonite (Ca-Mt) modified with Bi(3+) was used as a novel adsorbent for the sorption of Co(II) from aqueous solutions.	ca-mt)	35-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-119
21612864-1	2011	In this study, Ca-montmorillonite (Ca-Mt) modified with Bi(3+) was used as a novel adsorbent for the sorption of Co(II) from aqueous solutions.	bismuth(3+)	56-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-119
21612864-2	2011	The sorption of Co(II) on Bi-montmorillonite (Bi-Mt) was investigated as a function of contact time, pH, ionic strength, adsorbent content, Co(II) concentrations, fulvic acid (FA) and temperature.	fulvic acid	163-174	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-22
21813027-6	2011	In addition, Western blot analysis showed increased expression of epidermal growth factor receptor (EGFR) and Cox-2 in MCF-7/DOX cells.	Doxorubicin	125-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-115
21887866-1	2011	A novel dodecanuclear wheel with ten Dy(III) ions and two Co(II) ions bridged by four Schiff-base ligands and sixteen acetates represents the highest-nuclearity 3d-4f example of its type displaying single-molecule magnet behaviour.	Schiff Bases	86-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-64
21887866-1	2011	A novel dodecanuclear wheel with ten Dy(III) ions and two Co(II) ions bridged by four Schiff-base ligands and sixteen acetates represents the highest-nuclearity 3d-4f example of its type displaying single-molecule magnet behaviour.	Acetates	118-126	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-64
21813027-11	2011	CONCLUSIONS: We found that the invasive activity of MCF-7/DOX cells is mediated by Cox-2, which is induced by the EGFR-activated PI3K/Akt and MAPK pathways.	Doxorubicin	58-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
21813027-12	2011	In addition, EP1 and EP3 are important in the Cox-2-induced invasion of MCF-7/DOX cells.	Doxorubicin	78-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
21749063-1	2011	Os(II)/(III) and Co(II)/(III) polypyridine complexes in aqueous solution are robust molecular entities both in freely solute state and adsorbed on Au(111)- and Pt(111)-electrode surfaces.	PYRIDINE	30-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-23
22122764-4	2011	Among upregulated genes in tumour tissue is COX-2 which synthesises large amounts of PGE(2).	Prostaglandins E	85-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-49
22122764-7	2011	Aspirin and non-aspirin NSAIDs inhibit COX-2, subsequent PGE(2) formation and action by transcriptional and non-transcriptional mechanisms.	Aspirin	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-44
22122764-7	2011	Aspirin and non-aspirin NSAIDs inhibit COX-2, subsequent PGE(2) formation and action by transcriptional and non-transcriptional mechanisms.	Aspirin	16-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-44
22122764-9	2011	Aspirin additionally acetylates COX-2, resulting in generation of "aspirin-triggered" lipoxins (ATL), a new class of anti-inflammatory/antitumour compounds.	Aspirin	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-37
22122764-9	2011	Aspirin additionally acetylates COX-2, resulting in generation of "aspirin-triggered" lipoxins (ATL), a new class of anti-inflammatory/antitumour compounds.	Aspirin	67-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-37
22122764-9	2011	Aspirin additionally acetylates COX-2, resulting in generation of "aspirin-triggered" lipoxins (ATL), a new class of anti-inflammatory/antitumour compounds.	Lipoxins	86-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-37
21645153-0	2011	Two novel aspirin analogues show selective cytotoxicity in primary chronic lymphocytic leukaemia cells that is associated with dual inhibition of Rel A and COX-2.	Aspirin	10-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	156-161
21816516-4	2011	It was found that the active compounds 3l, 3m and 3n intact mainly with Arg 44 amino acid, which may be involved in COX-2 inhibition.	Arginine	72-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-121
22090887-2	2011	In the mol-ecule, the Co(II) atom is six-coordinated in a distorted octa-hedral environment, binding to the bridging O atom of the bicyclo-heptane unit, to two O atoms from monodentate carboxyl-ate groups and to three water O atoms.	octa-hedral	68-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-28
22090887-2	2011	In the mol-ecule, the Co(II) atom is six-coordinated in a distorted octa-hedral environment, binding to the bridging O atom of the bicyclo-heptane unit, to two O atoms from monodentate carboxyl-ate groups and to three water O atoms.	bicyclo-heptane	131-146	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-28
22090887-2	2011	In the mol-ecule, the Co(II) atom is six-coordinated in a distorted octa-hedral environment, binding to the bridging O atom of the bicyclo-heptane unit, to two O atoms from monodentate carboxyl-ate groups and to three water O atoms.	carboxyl-ate	185-197	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-28
22090887-2	2011	In the mol-ecule, the Co(II) atom is six-coordinated in a distorted octa-hedral environment, binding to the bridging O atom of the bicyclo-heptane unit, to two O atoms from monodentate carboxyl-ate groups and to three water O atoms.	Water	218-223	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-28
21813027-7	2011	Inhibition of Cox-2, phosphoinositide 3-kinase (PI3K)/Akt, or mitogen-activated protein kinase (MAPK) pathways effectively inhibited the invasive activities of MCF-7/DOX cells.	Doxorubicin	166-169	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
21210228-10	2011	Furthermore, COX-2 signal was induced by nicotine treatment and is involved in nicotine-enhanced fibronectin expression.	Nicotine	41-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
21645153-8	2011	In terms of their molecular mechanisms of action, 4HBZ and 2HBZ inhibited COX-2 transcription and protein expression and this was associated with upstream inhibition of transcription factor Rel A.	4hbz	50-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
21645153-8	2011	In terms of their molecular mechanisms of action, 4HBZ and 2HBZ inhibited COX-2 transcription and protein expression and this was associated with upstream inhibition of transcription factor Rel A.	2hbz	59-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
21645153-10	2011	Importantly, the most potent analogue, 4HBZ, overcame pro-survival effects of the co-culture system and significantly repressed COX-2.	4hbz	39-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	128-133
21645153-11	2011	Finally, elevated COX-2 expression was associated with poor prognostic subsets and increased sensitivity to 4HBZ.	4hbz	108-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-23
21645153-12	2011	CONCLUSIONS: Our results demonstrate therapeutic potential of 4HBZ and are consistent with a mechanism involving suppression of Rel A nuclear translocation and inhibition of COX-2 transcription.	4hbz	62-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	174-179
22053694-7	2011	A spectrophotometric assay involving co-oxidation of tetramethyl-p-phenylene diamine (TMPD) during the reduction of prostaglandin G2 (PGG2) to PGH2 was adopted and standardized for screening of compounds against COX-1 and COX-2.	tetramethyl-p-phenylenediamine	53-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	222-227
22053694-7	2011	A spectrophotometric assay involving co-oxidation of tetramethyl-p-phenylene diamine (TMPD) during the reduction of prostaglandin G2 (PGG2) to PGH2 was adopted and standardized for screening of compounds against COX-1 and COX-2.	tetramethyl-p-phenylenediamine	86-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	222-227
22053694-7	2011	A spectrophotometric assay involving co-oxidation of tetramethyl-p-phenylene diamine (TMPD) during the reduction of prostaglandin G2 (PGG2) to PGH2 was adopted and standardized for screening of compounds against COX-1 and COX-2.	prostaglandin G2	116-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	222-227
22053694-7	2011	A spectrophotometric assay involving co-oxidation of tetramethyl-p-phenylene diamine (TMPD) during the reduction of prostaglandin G2 (PGG2) to PGH2 was adopted and standardized for screening of compounds against COX-1 and COX-2.	prostaglandin G2	134-138	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	222-227
22066110-3	2011	However, little is known about the role of COX-2 in acquired resistance to 5-FU in colon cancer.	Fluorouracil	75-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
22066110-4	2011	METHODS: Hence we investigated whether COX-2 contribute to acquired resistance to 5-FU in colon cancer cells, using cytotoxicity assay for cell survival, reverse transcription-polymerase chain reaction (RT-PCR) for vascular endothelial growth factor (VEGF), quantitative RT-PCR for COX-1 and COX-2, and enzyme-linked immunosorbent assay for PGE(2).	Fluorouracil	82-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-44
22066110-5	2011	RESULTS: The 5-FU resistant colon cancer cells, SNU-C5/5FUR, showed increased expression of COX-2, prostaglandin E(2) (PGE(2)), and VEGF, compared to its parental cell (SNU-C5).	Fluorouracil	13-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-97
22066110-7	2011	CONCLUSION: These results demonstrate that COX-2 derived PGE(2) is up-regulated and COX-2 inhibitor may have an anti-angiogenic effect in the colon cancer cells resistant to 5-FU.	Prostaglandins E	57-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
22066110-7	2011	CONCLUSION: These results demonstrate that COX-2 derived PGE(2) is up-regulated and COX-2 inhibitor may have an anti-angiogenic effect in the colon cancer cells resistant to 5-FU.	Fluorouracil	174-178	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
22066110-7	2011	CONCLUSION: These results demonstrate that COX-2 derived PGE(2) is up-regulated and COX-2 inhibitor may have an anti-angiogenic effect in the colon cancer cells resistant to 5-FU.	Fluorouracil	174-178	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-89
21847358-4	2011	The coculture of PDAC and CAF cell lines enhanced the levels of inflammatory factors including IL-1alpha, IL-6, CXCL8, VEGF-A, CCL20, and COX-2.	pdac	17-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	138-143
21868314-7	2011	Both the non-selective COX inhibitor indomethacin and the selective COX-2 inhibitor SC-236 completely abolished EGF-induced PGE(2) release, and suppressed the mitogenic effect of EGF.	4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide	84-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-73
21868314-7	2011	Both the non-selective COX inhibitor indomethacin and the selective COX-2 inhibitor SC-236 completely abolished EGF-induced PGE(2) release, and suppressed the mitogenic effect of EGF.	Prostaglandins E	124-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-73
21936449-0	2011	COX-2 inhibitor, celecoxib, may prevent lung cancer.	Celecoxib	17-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
21699992-1	2011	Cultured preadipocytes enhance the synthesis of prostaglandin (PG) E(2) and PGF(2alpha) involving the induction of cyclooxygenase (COX)-2 during the growth phase upon stimulation with a mixture of phorbol 12-myristate 13-acetate, a mitogenic factor, and calcium ionophore A23187.	Prostaglandins E	48-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-137
21699992-1	2011	Cultured preadipocytes enhance the synthesis of prostaglandin (PG) E(2) and PGF(2alpha) involving the induction of cyclooxygenase (COX)-2 during the growth phase upon stimulation with a mixture of phorbol 12-myristate 13-acetate, a mitogenic factor, and calcium ionophore A23187.	Prostaglandins F	76-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-137
21699992-1	2011	Cultured preadipocytes enhance the synthesis of prostaglandin (PG) E(2) and PGF(2alpha) involving the induction of cyclooxygenase (COX)-2 during the growth phase upon stimulation with a mixture of phorbol 12-myristate 13-acetate, a mitogenic factor, and calcium ionophore A23187.	Tetradecanoylphorbol Acetate	197-228	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-137
21699992-1	2011	Cultured preadipocytes enhance the synthesis of prostaglandin (PG) E(2) and PGF(2alpha) involving the induction of cyclooxygenase (COX)-2 during the growth phase upon stimulation with a mixture of phorbol 12-myristate 13-acetate, a mitogenic factor, and calcium ionophore A23187.	Calcimycin	272-278	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-137
21699992-3	2011	15d-PGJ(2) interfered significantly the endogenous synthesis of those PGs in response to cell stimuli by suppressing the induction of COX-2 following the attenuation of NF-kappaB activation.	15d-pgj	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-139
21699992-3	2011	15d-PGJ(2) interfered significantly the endogenous synthesis of those PGs in response to cell stimuli by suppressing the induction of COX-2 following the attenuation of NF-kappaB activation.	Phosphatidylglycerols	70-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-139
21810512-7	2011	Regular use of aspirin or cyclooxygenase (COX)-2 inhibitors decrease recurrence rates and increase serum vitamin D levels.	Vitamin D	105-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-48
21796157-0	2011	Celecoxib and acetylbritannilactone interact synergistically to suppress breast cancer cell growth via COX-2-dependent and -independent mechanisms.	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-108
21796157-0	2011	Celecoxib and acetylbritannilactone interact synergistically to suppress breast cancer cell growth via COX-2-dependent and -independent mechanisms.	acetylbritannilactone	14-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-108
21796157-4	2011	ABL enhanced the apoptotic effect of celecoxib in COX-2-expressing cells, but had little effect in COX-2-negative cells.	Celecoxib	37-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-55
21688331-1	2011	Crystal structures of two metal-organic frameworks (MFU-1 and MFU-2) are presented, both of which contain redox-active Co(II) centres coordinated by linear 1,4-bis[(3,5-dimethyl)pyrazol-4-yl] ligands.	Metals	26-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-125
21688331-1	2011	Crystal structures of two metal-organic frameworks (MFU-1 and MFU-2) are presented, both of which contain redox-active Co(II) centres coordinated by linear 1,4-bis[(3,5-dimethyl)pyrazol-4-yl] ligands.	1,4-bis[(3,5-dimethyl)pyrazol-4-yl	156-190	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-125
20812865-5	2011	The accumulation of H(2)S over time causes progressive COX deficiency in animal tissues and human cells, which is associated with reduced amount of COX holoenzyme, and of several COX subunits, including mitochondrially encoded cytochrome c oxidase 1 (MTCO1), MTCO2, COX4, and COX5A.	Hydrogen Sulfide	20-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	259-264
21836897-4	2011	A distorted octahedral coordination geometry of the Co(II) atom results from ligation of an H atom, which is part of an agostic B-H Co inter-action [H Co = 2.12 (3) A], and by five imine N atoms, two from a Bp ligand and three from a Tp ligand.	imine n	181-188	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-58
21836897-4	2011	A distorted octahedral coordination geometry of the Co(II) atom results from ligation of an H atom, which is part of an agostic B-H Co inter-action [H Co = 2.12 (3) A], and by five imine N atoms, two from a Bp ligand and three from a Tp ligand.	Benzo(a)pyrene	207-209	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-58
21836897-4	2011	A distorted octahedral coordination geometry of the Co(II) atom results from ligation of an H atom, which is part of an agostic B-H Co inter-action [H Co = 2.12 (3) A], and by five imine N atoms, two from a Bp ligand and three from a Tp ligand.	tp	234-236	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-58
21836963-1	2011	In the title compound, [Co(C(20)H(18)P)I(C(3)H(9)P)(2)], the Co(II) atom has a distorted square-pyramidal geometry, the base of which is comprised of two trans PMe(3) groups, an I atom, and a C atom of the benzyl group.	co(c(20)h(18)p	24-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-67
21836963-1	2011	In the title compound, [Co(C(20)H(18)P)I(C(3)H(9)P)(2)], the Co(II) atom has a distorted square-pyramidal geometry, the base of which is comprised of two trans PMe(3) groups, an I atom, and a C atom of the benzyl group.	c(3)h(9)p	41-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-67
21615439-7	2011	In ex vivo/in vitro studies, bile acids stimulated squamous oesophageal cells and Barrett"s epithelial cells to produce inflammatory mediators (e.g., IL-8 and COX-2) and caused oxidative stress, DNA damage and apoptosis.	Bile Acids and Salts	29-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	159-164
21780552-1	2011	OBJECTIVE: The mechanism of action of non-steroidal anti-inflammatory drugs (NSAIDs), to which ketoprofen belongs, is based on their cyclo-oxigenase (COX) inhibiting action, concerning both subtype COX-1 constitutive isoform and COX-2 inducible isoform.	Ketoprofen	95-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	229-234
21340650-5	2011	RESULTS: DMF inhibited the MIF-induced phosphorylation of MSK1, RSK1, CREB and JunB, and reduced Cox-2 expression and the proliferation of cultured human keratinocytes.	Dimethyl Fumarate	9-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
21397936-1	2011	BACKGROUND: Researchers have debated whether regulation of the COX enzymes (COX-1 and COX-2), which mediate production of prostaglandins (PGs), affects the pathogenesis of nasal polyps (NPs) and aspirin-intolerant asthma (AIA).	Prostaglandins	122-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-91
21397936-1	2011	BACKGROUND: Researchers have debated whether regulation of the COX enzymes (COX-1 and COX-2), which mediate production of prostaglandins (PGs), affects the pathogenesis of nasal polyps (NPs) and aspirin-intolerant asthma (AIA).	Prostaglandins	138-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-91
21886896-1	2011	A new group of 5,5-diarylhydantoin derivatives bearing a methylsulfonyl COX-2 pharmacophore at the para position of the C-5 phenyl ring were designed and synthesized as selective COX-2 inhibitors.	5,5-diarylhydantoin	15-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
21886896-1	2011	A new group of 5,5-diarylhydantoin derivatives bearing a methylsulfonyl COX-2 pharmacophore at the para position of the C-5 phenyl ring were designed and synthesized as selective COX-2 inhibitors.	5,5-diarylhydantoin	15-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	179-184
21886896-2	2011	In vitro COX-1/COX-2 inhibition structure-activity relationships identified 5-[4-(methylsulfonyl)phenyl]-5-phenyl-hydantoin (4) as a highly potent and selective COX-2 inhibitor (COX-2 IC(50) = 0.077 muM; selectivity index &gt; 1298).	5-[4-(methylsulfonyl)phenyl]-5-phenyl-hydantoin	76-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-20
21886896-2	2011	In vitro COX-1/COX-2 inhibition structure-activity relationships identified 5-[4-(methylsulfonyl)phenyl]-5-phenyl-hydantoin (4) as a highly potent and selective COX-2 inhibitor (COX-2 IC(50) = 0.077 muM; selectivity index &gt; 1298).	5-[4-(methylsulfonyl)phenyl]-5-phenyl-hydantoin	76-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	161-166
21886896-2	2011	In vitro COX-1/COX-2 inhibition structure-activity relationships identified 5-[4-(methylsulfonyl)phenyl]-5-phenyl-hydantoin (4) as a highly potent and selective COX-2 inhibitor (COX-2 IC(50) = 0.077 muM; selectivity index &gt; 1298).	5-[4-(methylsulfonyl)phenyl]-5-phenyl-hydantoin	76-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	161-166
21886896-3	2011	It was more selective than the reference drug celecoxib (COX-2 IC(50) = 0.060 muM; selectivity index = 405).	Celecoxib	46-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-62
21886896-4	2011	A molecular modeling study where 4 was docked in the binding site of COX-2 indicated that the p-MeSO(2) COX-2 pharmacophore group on the C-5 phenyl ring is oriented in the vicinity of the COX-2 secondary pocket.	p-meso	94-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-74
21886896-4	2011	A molecular modeling study where 4 was docked in the binding site of COX-2 indicated that the p-MeSO(2) COX-2 pharmacophore group on the C-5 phenyl ring is oriented in the vicinity of the COX-2 secondary pocket.	p-meso	94-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
21886896-4	2011	A molecular modeling study where 4 was docked in the binding site of COX-2 indicated that the p-MeSO(2) COX-2 pharmacophore group on the C-5 phenyl ring is oriented in the vicinity of the COX-2 secondary pocket.	p-meso	94-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
21886896-5	2011	The results of this study showed that the type of substituent on the N-3 hydantoin ring substituent is important for COX-2 inhibitory activity.	n-3 hydantoin	69-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-122
21866663-3	2011	The effects of Hp on COX-2 mRNA and protein expressions in human gastric cancer cell line MKN 45 were observed using blocking p38MAPK signal transduction pathway by p38MAPK specific inhibitor SB203580.	SB 203580	192-200	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-26
21612192-1	2011	The interaction between Co(II) and Cu(II) ions with a Py(2)N(4)S(2)-coordinating octadentate macrocyclic ligand (L) to afford dinuclear compounds has been investigated.	octadentate	81-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-30
21612192-8	2011	The magnetic behavior is consistent with the existence of antiferromagnetic interactions between the ions for cobalt(II) and copper(II) complexes, while for the Co(II) ones, this behavior could also be explained by spin-orbit coupling.	Cobalt(2+)	110-120	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	161-167
21612192-8	2011	The magnetic behavior is consistent with the existence of antiferromagnetic interactions between the ions for cobalt(II) and copper(II) complexes, while for the Co(II) ones, this behavior could also be explained by spin-orbit coupling.	cupric ion	125-135	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	161-167
19922946-7	2011	Additionally, we show that triptolide treatment decreased expression of VEGF and COX-2, which promote cancer progression and invasion, and inhibited the expression of multiple cytokine receptors potentially involved in cell migration and cancer metastasis, including the thrombin receptor, CXCR4, TNF receptors, and TGF-beta receptors.	triptolide	27-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-86
21552592-1	2011	A single-chain magnet consisting of Co(II) chains with (EO-N(3))(2) and (mu-COO)(2)(mu-EO-N(3)) bridges reversibly transforms into an antiferromagnetic phase with metamagnetic character and modified slow magnetic relaxation upon dehydration.	(eo-n(3))	55-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-42
21552592-1	2011	A single-chain magnet consisting of Co(II) chains with (EO-N(3))(2) and (mu-COO)(2)(mu-EO-N(3)) bridges reversibly transforms into an antiferromagnetic phase with metamagnetic character and modified slow magnetic relaxation upon dehydration.	mu-eo-n	84-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-42
21296065-9	2011	In this last category, we identified a structural family of coumarin-derived compounds (imperatorin, osthol and prenyletin), along with deracoxib, a drug in veterinary use for its COX2 inhibitory properties.	coumarin	60-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	180-184
21296065-9	2011	In this last category, we identified a structural family of coumarin-derived compounds (imperatorin, osthol and prenyletin), along with deracoxib, a drug in veterinary use for its COX2 inhibitory properties.	deracoxib	136-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	180-184
21729671-1	2011	PURPOSE: Within breast tissue, aromatase expression and activity is increased by prostaglandin E2, providing a rationale for combining the COX-2 inhibitor celecoxib with an aromatase inhibitor.	Dinoprostone	81-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-144
21729671-1	2011	PURPOSE: Within breast tissue, aromatase expression and activity is increased by prostaglandin E2, providing a rationale for combining the COX-2 inhibitor celecoxib with an aromatase inhibitor.	Celecoxib	155-164	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-144
21736310-2	2011	The networks here generally consist of (1) the persistent core component (denoted as CoTCPSB) of linear Co(II) aqua clusters (Co-O-Co-O-Co) integrated into 2D grids by 4,4"-bipyridine and TCPSB and (2) ancillary ligands (AL) on the two terminal Co(II) ions-these include DMF (N,N"-dimethylformamide), DMA (N,N"-dimethylacetamide), CH(3)CN, and water.	carboxyl radical	126-130	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-110
21736310-2	2011	The networks here generally consist of (1) the persistent core component (denoted as CoTCPSB) of linear Co(II) aqua clusters (Co-O-Co-O-Co) integrated into 2D grids by 4,4"-bipyridine and TCPSB and (2) ancillary ligands (AL) on the two terminal Co(II) ions-these include DMF (N,N"-dimethylformamide), DMA (N,N"-dimethylacetamide), CH(3)CN, and water.	Cobalt	85-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-110
21736310-2	2011	The networks here generally consist of (1) the persistent core component (denoted as CoTCPSB) of linear Co(II) aqua clusters (Co-O-Co-O-Co) integrated into 2D grids by 4,4"-bipyridine and TCPSB and (2) ancillary ligands (AL) on the two terminal Co(II) ions-these include DMF (N,N"-dimethylformamide), DMA (N,N"-dimethylacetamide), CH(3)CN, and water.	tcpsb	87-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-110
21762044-5	2011	Flurbiprofen axetil, a nonselective COX2 inhibitor, is most likely the causative agent in this case, although there are no prior reports of asthma caused by this agent.	flurbiprofen axetil	0-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-40
21823012-6	2011	The levels of TNF-alpha, IL-2, IL-6 and COX-2 were found to be substantially decreased in PBMCs in omega-3PUFA group as compared with control group at 5th and 7th day (P&lt;0.05 for all).	omega-3pufa	99-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
22103082-1	2011	Ti-containing MCM-48 (Ti-MCM-48) material with mesoporous structure was synthesized and characterized, and the absorption processes of Co(II) and Ni(II) on the material were investigated in detail in the present study.	Titanium	0-2	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-141
22103082-1	2011	Ti-containing MCM-48 (Ti-MCM-48) material with mesoporous structure was synthesized and characterized, and the absorption processes of Co(II) and Ni(II) on the material were investigated in detail in the present study.	mcm-48	14-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-141
22103082-1	2011	Ti-containing MCM-48 (Ti-MCM-48) material with mesoporous structure was synthesized and characterized, and the absorption processes of Co(II) and Ni(II) on the material were investigated in detail in the present study.	Titanium	22-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-141
22103082-3	2011	Optimum pH value for maximum adsorption rate is 8.0, and the saturated adsorption capacities of Ti-MCM-48 for Co(II) and Ni(II) are 9.870 and 22.94 mg g(-1) respectively, which are greater than those of the reported materials Adsorption isotherms of Co(II) and Ni(II) on Ti-MCM-48 accord well with the Langmuir adsorption models.	ti-mcm-48	96-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-116
22103082-3	2011	Optimum pH value for maximum adsorption rate is 8.0, and the saturated adsorption capacities of Ti-MCM-48 for Co(II) and Ni(II) are 9.870 and 22.94 mg g(-1) respectively, which are greater than those of the reported materials Adsorption isotherms of Co(II) and Ni(II) on Ti-MCM-48 accord well with the Langmuir adsorption models.	ti-mcm-48	96-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	250-256
22103082-3	2011	Optimum pH value for maximum adsorption rate is 8.0, and the saturated adsorption capacities of Ti-MCM-48 for Co(II) and Ni(II) are 9.870 and 22.94 mg g(-1) respectively, which are greater than those of the reported materials Adsorption isotherms of Co(II) and Ni(II) on Ti-MCM-48 accord well with the Langmuir adsorption models.	Nickel(2+)	261-267	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-116
22103082-3	2011	Optimum pH value for maximum adsorption rate is 8.0, and the saturated adsorption capacities of Ti-MCM-48 for Co(II) and Ni(II) are 9.870 and 22.94 mg g(-1) respectively, which are greater than those of the reported materials Adsorption isotherms of Co(II) and Ni(II) on Ti-MCM-48 accord well with the Langmuir adsorption models.	ti-mcm-48	271-280	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-116
21567098-1	2011	Increasing evidence suggests that celecoxib, a COX-2 inhibitor with potent anticancer activity exerts its effects not only through COX-2, but also through COX-2-independent mechanisms.	Celecoxib	34-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
21567098-1	2011	Increasing evidence suggests that celecoxib, a COX-2 inhibitor with potent anticancer activity exerts its effects not only through COX-2, but also through COX-2-independent mechanisms.	Celecoxib	34-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-136
21567098-1	2011	Increasing evidence suggests that celecoxib, a COX-2 inhibitor with potent anticancer activity exerts its effects not only through COX-2, but also through COX-2-independent mechanisms.	Celecoxib	34-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-136
21696181-2	2011	The Co(3)O(4)-SiO(2) composite, the surface of which is rich in silica and Co(II) species compared with normal Co(3)O(4), exhibited very high activity for CO oxidation even at a temperature as low as -76  C. A rather unusual temperature-dependent activity curve, with the lowest conversion at about 80  C, was observed with a normal feed gas (H(2)O content ~3 ppm).	co(3)o(4)	4-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-81
21696181-2	2011	The Co(3)O(4)-SiO(2) composite, the surface of which is rich in silica and Co(II) species compared with normal Co(3)O(4), exhibited very high activity for CO oxidation even at a temperature as low as -76  C. A rather unusual temperature-dependent activity curve, with the lowest conversion at about 80  C, was observed with a normal feed gas (H(2)O content ~3 ppm).	Silicon Dioxide	14-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-81
21696706-4	2011	Cyclooxygenase enzymes (COX-1 and COX-2) are candidate neuroinflammatory mediators that may contribute to the HI-induced demise of early oligodendrocyte progenitors and myelination.	hi	110-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-39
21696706-8	2011	Post-HI ibuprofen treatment significantly attenuated the P3 HI-induced increases in COX-2 protein expression as well as interleukin-1beta (IL-1beta) and tumour necrosis factor-alpha (TNF-alpha) levels in the brain.	Ibuprofen	8-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-89
21592656-0	2011	Sorption behaviour of Co(II) and Cu(II) on chitosan in presence of nitrilotriacetic acid.	Nitrilotriacetic Acid	67-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-28
21756326-8	2011	In addition, combined membranous EGFR/COX-2 expression was significantly related to unfavorable overall survival (HR 7.2, CI 2.3-22.1, p = 0.001).In cell culture, we observed a suppression of EGFR protein levels after exposure to Leptomycin B in OVCAR-3 and SKOV-3 cells.	leptomycin B	230-242	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-43
21513769-3	2011	The results reveal that PCB126 stimulated the vasoconstriction factors COX-2 and PGF(2alpha) in HUVEC.	3,4,5,3',4'-pentachlorobiphenyl	24-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-76
21513769-4	2011	An up-regulation of COX-2 expression was demonstrated using qRT-PCR, western blot and immunofluorescence and increased production of PGF(2alpha) was demonstrated using LC/MS2 and enzyme immunoassay.	Prostaglandins F	133-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-25
21513769-6	2011	The addition of E2 enhanced PCB126-induced transcription of CYP1A1, CYP1B1 and COX-2 in HUVEC whereas an increased transcription of eNOS only occurred following combined treatment with E2 and PCB126.	3,4,5,3',4'-pentachlorobiphenyl	28-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-84
21513769-6	2011	The addition of E2 enhanced PCB126-induced transcription of CYP1A1, CYP1B1 and COX-2 in HUVEC whereas an increased transcription of eNOS only occurred following combined treatment with E2 and PCB126.	Estradiol	16-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-84
21657220-0	2011	Magnetic systems with mixed carboxylate and azide bridges: slow relaxation in Co(II) metamagnet and spin frustration in Mn(II) compound.	Azides	44-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-84
21657220-2	2011	In compound 1, the anionic uniform Co(II) chains with mixed (mu-EO-N(3))(2)(mu-COO) triple bridges (EO = end-on) are cross-linked by the cationic bis(pyridinium) spacers to generate 2D coordination layers.	bis(pyridinium)	146-161	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-41
21641217-4	2011	The prodrug ester 14 is a selective COX-2 inhibitor that exhibited AI activity (ED(50)=72.2mmol/kg po) between that of the reference drugs celecoxib (ED(50)=30.9mumol/kg po) and ibuprofen (ED(50)=327mumol/kg po).	Esters	12-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-41
21641217-6	2011	These studies indicate hybrid ester AI/NO donor prodrugs (NONO-coxibs) constitutes a plausible drug design concept targeted toward the development of selective COX-2 inhibitory AI drugs that are devoid of adverse cardiovascular effects.	Esters	30-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	160-165
21430074-0	2011	Enforced expression of miR-101 inhibits prostate cancer cell growth by modulating the COX-2 pathway in vivo.	mir-101	23-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-91
21430074-2	2011	COX-2, a key regulator of inflammation-producing prostaglandins, promotes cell proliferation and growth; thus, overexpression of COX-2 is often found in tumor tissues.	Prostaglandins	49-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
21430074-2	2011	COX-2, a key regulator of inflammation-producing prostaglandins, promotes cell proliferation and growth; thus, overexpression of COX-2 is often found in tumor tissues.	Prostaglandins	49-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-134
21430074-4	2011	In this study, we investigated the mechanism of microRNA-101 (miR-101)-regulated COX-2 expression and the therapeutic potential of exogenous miR-101 for COX-2-associated cancer.	mir-101	62-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-86
21430074-4	2011	In this study, we investigated the mechanism of microRNA-101 (miR-101)-regulated COX-2 expression and the therapeutic potential of exogenous miR-101 for COX-2-associated cancer.	mir-101	141-148	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	153-158
21430074-6	2011	We found that miR-101 inhibited COX-2 posttranscriptional expression by directly binding to the 3"-untranslated region (3"-UTR) of COX-2 mRNA.	mir-101	14-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-37
21430074-6	2011	We found that miR-101 inhibited COX-2 posttranscriptional expression by directly binding to the 3"-untranslated region (3"-UTR) of COX-2 mRNA.	mir-101	14-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-136
21430074-13	2011	These data suggest that exogenous miR-101 may provide a new cancer therapy by directly inhibiting COX-2 expression.	mir-101	34-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-103
21561856-6	2011	In addition, similar to the effect of the PI3K inhibitor LY294002, caffeine also inhibited phosphorylation of AKT and up-regulation of COX-2, two critical oncogenic pathways in skin tumorigenesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	57-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-140
21561856-6	2011	In addition, similar to the effect of the PI3K inhibitor LY294002, caffeine also inhibited phosphorylation of AKT and up-regulation of COX-2, two critical oncogenic pathways in skin tumorigenesis.	Caffeine	67-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-140
21561856-9	2011	Inhibiting AKT by caffeine blocked UVB-induced COX-2 up-regulation.	Caffeine	18-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
21561856-12	2011	These findings indicate that in HaCaT keratinocytes, inhibiting the AKT/COX-2 pathways through an ATR-independent pathway is a critical molecular mechanism by which caffeine promotes UVB-induced apoptosis of unrepaired keratinocytes for elimination.	Caffeine	165-173	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
21347567-10	2011	CONCLUSION: Due to better sensitivity and similar drug-induced inhibition, the biomarker PGE(2) and the antipyretic effect would be suitable alternative endpoints to the analgesic effects for characterization and comparisons of potency and time-courses of drug candidates affecting the COX-2 pathway and to support human dose projections.	Dinoprostone	89-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	286-291
21523305-9	2011	6 is a mixed-valence trinuclear cobalt complex, which is formulated as Co(III)(S = 0)-Co(II)(S = 3/2)-Co(III)(S = 0).	Cobalt	32-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-92
21523305-9	2011	6 is a mixed-valence trinuclear cobalt complex, which is formulated as Co(III)(S = 0)-Co(II)(S = 3/2)-Co(III)(S = 0).	co(iii)	71-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-92
21523305-9	2011	6 is a mixed-valence trinuclear cobalt complex, which is formulated as Co(III)(S = 0)-Co(II)(S = 3/2)-Co(III)(S = 0).	co(iii)	102-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-92
21677839-7	2011	RESULTS: Nicotine upregulated periostin in gastric cancer cells through a COX-2 dependent pathway, which was blocked by the COX-2-specific inhibitor NS398.	Nicotine	9-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
21677839-7	2011	RESULTS: Nicotine upregulated periostin in gastric cancer cells through a COX-2 dependent pathway, which was blocked by the COX-2-specific inhibitor NS398.	Nicotine	9-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	124-129
21677839-7	2011	RESULTS: Nicotine upregulated periostin in gastric cancer cells through a COX-2 dependent pathway, which was blocked by the COX-2-specific inhibitor NS398.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	149-154	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
21677839-7	2011	RESULTS: Nicotine upregulated periostin in gastric cancer cells through a COX-2 dependent pathway, which was blocked by the COX-2-specific inhibitor NS398.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	149-154	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	124-129
21754669-1	2011	In the title compound, [Co(NO(3))(2)(C(18)H(16)N(2)O(2))(2)](n), the Co(II) ion is located on an inversion center and is six-coordinated in an octa-hedral environment defined by four N atoms of the pyridine rings and two O atoms of the nitrate anions.	co(no(3)	24-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-75
21754669-1	2011	In the title compound, [Co(NO(3))(2)(C(18)H(16)N(2)O(2))(2)](n), the Co(II) ion is located on an inversion center and is six-coordinated in an octa-hedral environment defined by four N atoms of the pyridine rings and two O atoms of the nitrate anions.	Nitrogen	27-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-75
21754669-1	2011	In the title compound, [Co(NO(3))(2)(C(18)H(16)N(2)O(2))(2)](n), the Co(II) ion is located on an inversion center and is six-coordinated in an octa-hedral environment defined by four N atoms of the pyridine rings and two O atoms of the nitrate anions.	pyridine	198-206	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-75
21754669-1	2011	In the title compound, [Co(NO(3))(2)(C(18)H(16)N(2)O(2))(2)](n), the Co(II) ion is located on an inversion center and is six-coordinated in an octa-hedral environment defined by four N atoms of the pyridine rings and two O atoms of the nitrate anions.	Nitrates	236-243	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-75
21210228-10	2011	Furthermore, COX-2 signal was induced by nicotine treatment and is involved in nicotine-enhanced fibronectin expression.	Nicotine	79-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
20956097-5	2011	Further we analyzed the effect of sulforaphane on the expression of Bcl-2, COX-2 and IL-1beta by RT-PCR on HeLa cells.	sulforaphane	34-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
21530248-6	2011	Each compound was tested by NF-kappaB luciferase assay and three rosmarinic acid analogues inhibited NF-kappaB production and the induction of COX-2 and iNOS mRNA in HepG2 cells.	rosmarinic acid	65-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	143-148
20956097-8	2011	Also, the expression analysis of genes involved in apoptosis and inflammation revealed significant downregulation of Bcl-2, COX-2 and IL-1beta upon treatment with sulforaphane.	sulforaphane	163-175	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	124-129
21420233-6	2011	This results in combinatorial inhibition of NFkappaB activity by gallic acid, which results in potent inhibition of NFkappaB target genes involved in inflammation, metastasis, anti-apoptosis and angiogenesis, such as IL-6, IL-8, COX2, CXCR4, XIAP, bcl2, VEGF.	Gallic Acid	65-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	229-233
21354147-1	2011	BACKGROUND &amp; AIMS: Microsomal prostaglandin E synthase-1 (mPGES-1) is a rate-limiting enzyme that is coupled with cyclooxygenase (COX)-2 in the synthesis of prostaglandin E2.	Adenosine Monophosphate	12-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-140
21459756-2	2011	The aim of this study was to find out whether butyrate affects the tumor-promoting genes osteopontin (OPN) and cyclooxygenase (COX)-2, their respective proteins and/or their functional activity in matched normal, adenoma and tumor colon tissues obtained from 20 individuals at colon cancer surgery.	Butyrates	46-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	111-133
21459756-4	2011	The addition of butyrate reduced OPN and COX-2 mRNA expression in all tissue types compared with the related medium controls (tumor: P &lt; 0.05).	Butyrates	16-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-46
21459756-8	2011	The active proteins of OPN and COX-2 (determined by prostaglandin E(2)) were found to correlate with their respective mRNA expression only in 50-63% of analyzed donors.	Dinoprostone	52-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-36
21459756-9	2011	For the first time, our data reveal new insights into the chemoprotective potential of butyrate by showing the suppression of OPN and COX-2 mRNA in primary human colon tissue with the strongest effects observed in tumors.	Butyrates	87-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-139
21354147-1	2011	BACKGROUND &amp; AIMS: Microsomal prostaglandin E synthase-1 (mPGES-1) is a rate-limiting enzyme that is coupled with cyclooxygenase (COX)-2 in the synthesis of prostaglandin E2.	Dinoprostone	161-177	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-140
20939764-4	2011	Metal complexes are [M(LH)Cl(2)] and [M(LH)(2)Cl(2)] type, where M = Fe(III), Co(II), and Cu(II) and LH = IPMCHTSC and IPMCHPhTSC.	Metals	0-5	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-83
21069571-9	2011	Dexamethasone attenuated LPS-induced IL-1 beta (IC(50) = 70 nM), IL-6 (IC(50) = 58 nM) and TNF-alpha (IC(50) = 44 nM) release, whereas celecoxib, a specific COX-2 inhibitor showed marked reduction in LPS-induced PGE(2) (IC(50) = 23 nM) production.	Dexamethasone	0-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	157-162
21113620-0	2011	The effect of COX-2 inhibitor on capecitabine-induced hand-foot syndrome in patients with stage II/III colorectal cancer: a phase II randomized prospective study.	Capecitabine	33-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
21113620-2	2011	It is hypothesized that capecitabine (Hoffmann-La Roche Inc.) based chemotherapy can cause overexpression of COX-2 in tumor and healthy tissue, which finally induced HFS in hands and feet.	Capecitabine	24-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-114
21113620-3	2011	Based on this, we believed that a selected COX-2 inhibitor (celecoxib, Pfizer Pharmaceuticals LLC) could ease HFS.	Celecoxib	60-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
21557245-16	2011	Furthermore, exogenous TGF-beta1 elicits induction of COX-2, suggesting inherent complexity regarding these processes and PGE2 signaling, specifically.	Dinoprostone	122-126	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-59
23717062-0	2011	Ginsenoside Rp1, a Ginsenoside Derivative, Blocks Promoter Activation of iNOS and COX-2 Genes by Suppression of an IKKbeta-mediated NF-kB Pathway in HEK293 Cells.	Ginsenosides	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
21491446-1	2011	Nimesulide is a nonsteroidal anti-inflammatory drug (NSAID) and a COX-2 inhibitor.	nimesulide	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-71
21523557-7	2011	In conclusion, capsaicin-at concentrations clinically applied or under investigation for diverse disease backgrounds-induces a vasodilatory response in human nasal mucosa via a mechanism involving TRPV1-independent reduction of PGE(2) production by modulation of COX-2 enzymatic activity.	capsaicin-at	15-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	263-268
21436263-3	2011	We demonstrate that different regulatory elements are required for regulation of Cox2 expression by BMP-2: Runt-related transcription factor-2 and cAMP response element sites are essential, whereas a GC-rich Smad binding element is important for full responsiveness.	Cyclic AMP	147-151	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-85
21426233-7	2011	Accordingly, 18beta-glycyrrhetic acid prevented HMGB1-dependent COX2 expression and cluster formation in primary cultures of human macrophages.	Glycyrrhetinic Acid	13-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-68
21688615-4	2011	Two drugs recently approved for health insurance reimbursement, celecoxib, a cyclooxygenase (COX)-2 specific inhibitor and low-dose lansoprazole for prevention of recurrent peptic ulcer due to LDA/NSAIDs will be instrumental in mitigating the gastrointestinal injuries.	Celecoxib	64-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-99
21688627-4	2011	The GI protection that is associated with the use of COX-2 selective agents is largely lost when low-dose aspirin is administered concurrently for CV prophylaxis.	Aspirin	106-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-58
21420899-0	2011	Synthesis, spectral characterization and biological activities of Mn(II) and Co(II) complexes with benzyloxybenzaldehyde-4-phenyl-3-thiosemicarbazone.	benzyloxybenzaldehyde-4-phenyl-3-thiosemicarbazone	99-149	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-83
21420899-1	2011	Mn(II) and Co(II) complexes of benzyloxybenzaldehyde-4-phenyl-3-thiosemicarbazone have been synthesized and characterized by the investigations of electronic and EPR spectra and X-ray diffraction.	benzyloxybenzaldehyde-4-phenyl-3-thiosemicarbazone	31-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-17
21333731-9	2011	In addition, RSG also inhibited the decrease of COX-2 expression induced by high glucose through activating PPARgamma.	Rosiglitazone	13-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-53
21333731-9	2011	In addition, RSG also inhibited the decrease of COX-2 expression induced by high glucose through activating PPARgamma.	Glucose	81-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-53
21333731-10	2011	Furthermore, the activation of Akt and MAPKs was involved in the effect of RSG on Nrf2, HO-1 and COX-2.	Rosiglitazone	75-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
21627839-2	2011	We evaluated the antitumor activity and safety of the combination carboplatin plus the COX-2 inhibitor celecoxib in recurrent heavily-treated OC patients.	Celecoxib	103-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-92
21542630-1	2011	Dual target inhibitors against COX-2 and LTA(4)H were designed by adding functional groups from a marketed COX-2 inhibitor, Nimesulide, to an existing LTA(4)H inhibitor 1-(2-(4-phenoxyphenoxy) ethyl) pyrrolidine.	nimesulide	124-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-36
21542630-1	2011	Dual target inhibitors against COX-2 and LTA(4)H were designed by adding functional groups from a marketed COX-2 inhibitor, Nimesulide, to an existing LTA(4)H inhibitor 1-(2-(4-phenoxyphenoxy) ethyl) pyrrolidine.	nimesulide	124-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-112
21542630-1	2011	Dual target inhibitors against COX-2 and LTA(4)H were designed by adding functional groups from a marketed COX-2 inhibitor, Nimesulide, to an existing LTA(4)H inhibitor 1-(2-(4-phenoxyphenoxy) ethyl) pyrrolidine.	1-(2-(4-phenoxyphenoxy) ethyl) pyrrolidine	169-211	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-36
21524587-2	2011	Previous studies have shown that esters and amides of non-selective inhibitors such as indomethacin are selective against COX-2, which is the therapeutically relevant isoform.	Esters	33-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-127
21600026-5	2011	RESULTS: Applying the model in a retrospective real-world scenario identified that the majority of the sample group of Australian patients aged 65 years and over with the target morbidity of the newly released COX-2-selective NSAID rofecoxib also suffered from a major morbidity excluded in the trials of that drug, indicating a substantial potential risk of adverse events amongst those patients.	rofecoxib	232-241	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	210-215
21524587-2	2011	Previous studies have shown that esters and amides of non-selective inhibitors such as indomethacin are selective against COX-2, which is the therapeutically relevant isoform.	Amides	44-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-127
21524587-2	2011	Previous studies have shown that esters and amides of non-selective inhibitors such as indomethacin are selective against COX-2, which is the therapeutically relevant isoform.	Indomethacin	87-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-127
21524587-4	2011	In the present study, the introduction of inorganic ortho- and meta-carbaborane moieties was explored with the aim to create COX-2 inhibitors and more importantly to investigate the validity of using these boron clusters as drug entities.	carbaborane	68-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-130
21488638-5	2011	We then performed late-stage, site-selective diversification of a sulfonamide drug candidate containing multiple potentially reactive C-H bonds to synthesize directly novel celecoxib analogues as potential cyclooxygenase-II (COX-2)-specific inhibitors.	Sulfonamides	66-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	225-230
21488638-5	2011	We then performed late-stage, site-selective diversification of a sulfonamide drug candidate containing multiple potentially reactive C-H bonds to synthesize directly novel celecoxib analogues as potential cyclooxygenase-II (COX-2)-specific inhibitors.	Celecoxib	173-182	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	225-230
21480405-7	2011	Detailed magnetic studies of 1 2H(2)O revealed that the competitive interactions between interchain antiferromagnetic exchange coupling and single-ion anisotropy of Co(II) resulted in a partly canted antiferromagnetic sate in low fields.	2h(2)o	31-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	165-171
26610143-6	2011	It is found that the correlated ground state wave function consists of a closed-shell Co(I) (d(8)) configuration and a diradical contribution, which can be described as a Co(II) (d(7))-radical corrin (pi*)(1) configuration.	corrin	193-199	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	171-177
21416105-0	2011	The low spin Co(II) fragment with homoleptic 1,10-phenanthroline ligands: synthesis, structures, DFT investigations, and magnetic properties.	1,10-phenanthroline	45-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-19
21416105-1	2011	Two complexes {[Co(II)(phen)(3)][Co(III)(phen)(CN)(4)](2)} phen 11H(2)O (1) and [Co(II)(mu-CN)(2)(Co(III))(2)(phen)(4)(CN)(6)] C(2)H(5)OH 2H(2)O (2) were synthesized with identical starting materials but with a different order of addition.	(2)} phen 11h(	54-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-22
21416105-1	2011	Two complexes {[Co(II)(phen)(3)][Co(III)(phen)(CN)(4)](2)} phen 11H(2)O (1) and [Co(II)(mu-CN)(2)(Co(III))(2)(phen)(4)(CN)(6)] C(2)H(5)OH 2H(2)O (2) were synthesized with identical starting materials but with a different order of addition.	hippuric acid	68-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-22
21416105-4	2011	The first low-spin Co(II) fragment with homoleptic 1,10-phenanthroline ligands in 1 is observed at room temperature, owing to charge transfer from the neighboring anion via adventitious contacts and anion-pi interactions.	1,10-phenanthroline	51-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-24
21754318-1	2011	In the title compound, [Co(NO(3))(2)(C(18)H(16)N(2)O(2))], the Co(II) ion is six-coordinated in a distorted octa-hedral environment defined by two O and two N atoms from the ligand and by two O atoms from two nitrate anions.	co(no(3))	24-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-69
21754318-1	2011	In the title compound, [Co(NO(3))(2)(C(18)H(16)N(2)O(2))], the Co(II) ion is six-coordinated in a distorted octa-hedral environment defined by two O and two N atoms from the ligand and by two O atoms from two nitrate anions.	hippuric acid	49-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-69
21754318-1	2011	In the title compound, [Co(NO(3))(2)(C(18)H(16)N(2)O(2))], the Co(II) ion is six-coordinated in a distorted octa-hedral environment defined by two O and two N atoms from the ligand and by two O atoms from two nitrate anions.	octa-hedral	108-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-69
21754318-1	2011	In the title compound, [Co(NO(3))(2)(C(18)H(16)N(2)O(2))], the Co(II) ion is six-coordinated in a distorted octa-hedral environment defined by two O and two N atoms from the ligand and by two O atoms from two nitrate anions.	Nitrogen	27-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-69
21754318-1	2011	In the title compound, [Co(NO(3))(2)(C(18)H(16)N(2)O(2))], the Co(II) ion is six-coordinated in a distorted octa-hedral environment defined by two O and two N atoms from the ligand and by two O atoms from two nitrate anions.	Nitrates	209-216	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-69
21754320-3	2011	The Co(II) atom is in an almost octa-hedral environment formed by four carboxyl-ate O atoms from two malonate ligands and two water O atoms.	carboxyl-ate o	71-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
21754320-3	2011	The Co(II) atom is in an almost octa-hedral environment formed by four carboxyl-ate O atoms from two malonate ligands and two water O atoms.	malonic acid	101-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
21754320-3	2011	The Co(II) atom is in an almost octa-hedral environment formed by four carboxyl-ate O atoms from two malonate ligands and two water O atoms.	Water	126-131	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
21483935-2	2011	The computations clearly indicate the involvement of a cobalt "nitrene radical" intermediate in the Co(II)(por)-catalyzed alkene aziridination.	cobalt "nitrene radical	55-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-105
21483935-2	2011	The computations clearly indicate the involvement of a cobalt "nitrene radical" intermediate in the Co(II)(por)-catalyzed alkene aziridination.	Alkenes	122-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-105
21483935-7	2011	The computed free energy profile readily explains the superior performance of the Co(II)(porAmide) system with H-bond donor functionalities over the non-functionalized Co(TPP).	poramide	89-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
21483935-7	2011	The computed free energy profile readily explains the superior performance of the Co(II)(porAmide) system with H-bond donor functionalities over the non-functionalized Co(TPP).	cobalt(III)-tetrakis(4-sulfonatophenyl)porphyrin	168-175	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
21480405-7	2011	Detailed magnetic studies of 1 2H(2)O revealed that the competitive interactions between interchain antiferromagnetic exchange coupling and single-ion anisotropy of Co(II) resulted in a partly canted antiferromagnetic sate in low fields.	sate	218-222	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	165-171
22977519-12	2011	In conclusion, the combination of RSG and ATRA reduced the expression of COX-2, MMP-7 and TIMP-1, caused cell cycle arrest at the G1 phase and induced apoptosis, which resulted in the inhibition of cell proliferation in the HCT-15 human colorectal cancer cell line.	Rosiglitazone	34-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-78
21087344-1	2011	This study aimed to investigate the cancer stem cell (CSC) properties of radioresistant esophageal cancer cells and the radiosensitization effect of NS398, a cyclooxygenase (COX)-2 inhibitor, on them.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	149-154	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	158-180
21540248-4	2011	Furthermore, N-acetyl-l-cysteine (NAC, a radical scavenger) and celecoxib (a Cox-2 inhibitor) were used to explore the molecular mechanism.	Celecoxib	64-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-82
21261791-3	2011	Recently, we found that nicotine promoted tumor growth through upregulation of the COX-2/prostaglandin E(2) pathway.	Nicotine	24-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
21261791-3	2011	Recently, we found that nicotine promoted tumor growth through upregulation of the COX-2/prostaglandin E(2) pathway.	Dinoprostone	89-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
21540248-10	2011	In conclusion, these results suggest that increased ROS play a critical role in inhibiting invasion/migration by suppressing the Cox-2/MMP-2 pathway in As(2)O(3)-treated SGC-7901 cells and regulating intracellular ROS levels may be a promising strategy in gastric cancer therapy.	Reactive Oxygen Species	52-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-134
21540248-9	2011	Moreover, celecoxib significantly decreased Cox-2, MMP-2 and PGE2 expression and inhibited invasion/migration activity in As(2)O(3)-treated cells (P &lt; 0.05), indicating that As(2)O(3) inhibits invasion/migration by regulating the expression of Cox-2/PGE2/MMP-2.	Celecoxib	10-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-49
22977519-12	2011	In conclusion, the combination of RSG and ATRA reduced the expression of COX-2, MMP-7 and TIMP-1, caused cell cycle arrest at the G1 phase and induced apoptosis, which resulted in the inhibition of cell proliferation in the HCT-15 human colorectal cancer cell line.	Tretinoin	42-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-78
21540248-9	2011	Moreover, celecoxib significantly decreased Cox-2, MMP-2 and PGE2 expression and inhibited invasion/migration activity in As(2)O(3)-treated cells (P &lt; 0.05), indicating that As(2)O(3) inhibits invasion/migration by regulating the expression of Cox-2/PGE2/MMP-2.	Celecoxib	10-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	247-252
21359324-1	2011	The pH-dependent electrochemical behavior for a Co(II) complex, [Co(Py5)(OH(2))](ClO(4))(2) (1; Py5 = 2,6-(bis(bis-2-pyridyl)methoxymethane)pyridine), indicates consecutive (proton-coupled) oxidation steps furnish a Co(IV) species that catalyzes the oxidation of water in basic media.	co(py5)(oh(2))](clo(4))	65-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-54
21277322-0	2011	Preparation and characterization of chitosan-grafted-poly(2-amino-4,5-pentamethylene-thiophene-3-carboxylic acid N"-acryloyl-hydrazide) chelating resin for removal of Cu(II), Co(II) and Ni(II) metal ions from aqueous solutions.	poly(2-amino-4,5-pentamethylene-thiophene-3-carboxylic acid n"-acryloyl-hydrazide)	53-135	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	175-181
21438584-0	2011	Briarane diterpenes diminish COX-2 expression in human colon adenocarcinoma cells.	Diterpenes	9-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34
21826992-7	2011	CONCLUSION: Celecoxib has reversal effect on MDR in MCF-7/Taxol cells, it"s possible mechanism might be related to reduce the protein expression of COX-2, the inhibition of P-gp, BCRP mRNA and protein overexpression.	Celecoxib	12-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	148-153
21384049-0	2011	New metal-anion radical framework materials: Co(II) compounds showing ferromagnetic to antiferromagnetic phase transition at about 344 K, and Zn(II) compounds exhibiting terminal anion ligand induced direct white-light-emission.	metal-anion radical	4-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-50
21359324-1	2011	The pH-dependent electrochemical behavior for a Co(II) complex, [Co(Py5)(OH(2))](ClO(4))(2) (1; Py5 = 2,6-(bis(bis-2-pyridyl)methoxymethane)pyridine), indicates consecutive (proton-coupled) oxidation steps furnish a Co(IV) species that catalyzes the oxidation of water in basic media.	(bis(bis-2-pyridyl)methoxymethane)pyridine	106-148	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-54
21359324-1	2011	The pH-dependent electrochemical behavior for a Co(II) complex, [Co(Py5)(OH(2))](ClO(4))(2) (1; Py5 = 2,6-(bis(bis-2-pyridyl)methoxymethane)pyridine), indicates consecutive (proton-coupled) oxidation steps furnish a Co(IV) species that catalyzes the oxidation of water in basic media.	Water	263-268	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-54
21467612-1	2011	The open-chain polyether-bridged flexible ligand 1,2-bis[2-(1H-1,3-imidazol-1-ylmethyl)phenoxy]ethane (L) has been used to create two two-dimensional coordination polymers under hydrothermal reaction of L with Cd(II) or Co(II), in the presence of benzene-1,4-dicarboxylic acid (H(2)bdc).	polyether	15-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	220-226
21416515-3	2011	Here we report the exchange rates of water ligated to Co(II) atoms in two polyoxotungstate sandwich molecules using the (17)O-NMR-based Swift-Connick method.	Water	37-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-60
21416515-3	2011	Here we report the exchange rates of water ligated to Co(II) atoms in two polyoxotungstate sandwich molecules using the (17)O-NMR-based Swift-Connick method.	polyoxotungstate	74-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-60
21416515-9	2011	This dissociation is detectable by EPR spectroscopy as S=3/2 Co(II) species (such as the [Co(H(2)O)(6)](2+) monomer ion) and by the significant reduction of the Co-Co vector in the XAS spectra.	co(h(2)o)	90-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-67
21359327-4	2011	The Ni(II) complexes display DNA binding stronger than the corresponding Co(II) analogues, which is expected of their bigger sizes.	Nickel(2+)	4-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-79
21359327-11	2011	The CV and DPV responses indicate that the DNA-bound dpq complexes are stabilized in the lower oxidation state of Co(II) more than in the Co(III) oxidation state.	diperoxovanadate	11-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-120
21359327-11	2011	The CV and DPV responses indicate that the DNA-bound dpq complexes are stabilized in the lower oxidation state of Co(II) more than in the Co(III) oxidation state.	3,4-dihydro-5-(4-(1-piperidinyl)butoxy)-1(2H)-isoquinolinone	53-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-120
21391549-7	2011	The photo-conversion efficiency has been estimated at 20% of photo-induced high spin Fe(II) centers in [Fe(3)Co(2)], 30% of paramagnetic Co(II)-Fe(III) pairs in [Co(3)Fe(2)], and less than 2% of photo-induced high spin Fe(II) centers in [Fe(3)Fe(2)].	ferric sulfate	144-151	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-142
21391549-7	2011	The photo-conversion efficiency has been estimated at 20% of photo-induced high spin Fe(II) centers in [Fe(3)Co(2)], 30% of paramagnetic Co(II)-Fe(III) pairs in [Co(3)Fe(2)], and less than 2% of photo-induced high spin Fe(II) centers in [Fe(3)Fe(2)].	co(3)fe(2)	162-172	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-142
21209362-3	2011	Moreover, accumulating evidence suggests that eicosanoids derived from cyclooxygenase (COX)-2 participate in a number of pathological processes in immune-mediated renal diseases, and it is known that protein kinase B (AKT) may act through different transcription factors in the regulation of the COX-2 promoter.	Eicosanoids	46-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-93
21209362-3	2011	Moreover, accumulating evidence suggests that eicosanoids derived from cyclooxygenase (COX)-2 participate in a number of pathological processes in immune-mediated renal diseases, and it is known that protein kinase B (AKT) may act through different transcription factors in the regulation of the COX-2 promoter.	Eicosanoids	46-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	296-301
21209362-4	2011	The present results show that progressive accumulation of collagen I in the extracellular medium induces a significant increase of COX-2 expression in human mesangial cells, resulting in an enhancement in PGE(2) production.	Prostaglandins E	205-208	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-136
21209362-11	2011	In summary, our results provide evidence that collagen type I increases COX-2 expression via the FAK/PI3K/AKT/cAMP response element binding protein signaling pathway.	Cyclic AMP	110-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
21467612-1	2011	The open-chain polyether-bridged flexible ligand 1,2-bis[2-(1H-1,3-imidazol-1-ylmethyl)phenoxy]ethane (L) has been used to create two two-dimensional coordination polymers under hydrothermal reaction of L with Cd(II) or Co(II), in the presence of benzene-1,4-dicarboxylic acid (H(2)bdc).	1,2-bis[2-(1h-1,3-imidazol-1-ylmethyl)phenoxy]ethane	49-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	220-226
21210103-10	2011	Pycnoporus laccase and Suberase  oligorutins led to an inhibition of COX-2 of about 35% and 70%, respectively, while monomeric rutin showed a near-negligible inhibition effect, less than about 10%.	oligorutins	33-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-74
21210103-10	2011	Pycnoporus laccase and Suberase  oligorutins led to an inhibition of COX-2 of about 35% and 70%, respectively, while monomeric rutin showed a near-negligible inhibition effect, less than about 10%.	Rutin	38-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-74
21330379-4	2011	Isorhamnetin attenuated EGF-induced COX-2 expression in JB6 and A431 cells.	3-methylquercetin	0-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-41
22171305-1	2011	Aceclofenac has been shown to have potent analgesic and anti-inflammatory activities similar to indomethacin and diclofenac, and due to its preferential Cox-2 blockade, it has a better safety than conventional Non steroidal anti-inflammatory drug (NSAIDs) with respect to adverse effect on gastrointestinal and cardiovascular systems.	aceclofenac	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	153-158
21539467-9	2011	In a control experiment, patients (n = 6) treated with the selective COX-2 inhibitor etoricoxib (90 mg/day) for 8 weeks showed no changes in the number of pMPs, eMPs, and EPCs and in FMD.	Etoricoxib	85-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-74
21145050-2	2011	Also, COX-2 gene expression and prostaglandin E(2) production were induced in those cells by increasing COX-2 promoter transcription activity, which could be attenuated by a specific p38MAPK inhibitor, suggesting a role for peritoneal fluid in the etiopathogenesis of endometriosis.	Dinoprostone	32-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
21275896-4	2011	The COX exists at least in two isoforms, COX-1 and COX-2, with PGs mediating inflammation at site of injury generated by the COX-2, while COX-1 produces PGs that are essential in maintaining integrity in the gastrointestinal tract.	Prostaglandins	63-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-56
21275896-4	2011	The COX exists at least in two isoforms, COX-1 and COX-2, with PGs mediating inflammation at site of injury generated by the COX-2, while COX-1 produces PGs that are essential in maintaining integrity in the gastrointestinal tract.	Prostaglandins	63-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-130
21275896-4	2011	The COX exists at least in two isoforms, COX-1 and COX-2, with PGs mediating inflammation at site of injury generated by the COX-2, while COX-1 produces PGs that are essential in maintaining integrity in the gastrointestinal tract.	Prostaglandins	153-156	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-56
21075183-4	2011	It was found that compounds esterified with unsaturated fatty acids demonstrated significant COX-2 inhibitory effects, while in the COX-1 assay only 14-benzoylaconine-8-O-eicosapentaenoate exerted remarkable activity.	Fatty Acids, Unsaturated	44-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-98
22171305-2	2011	Aceclofenac is superior from other NSAIDs as it has selectivity for Cox-2, a beneficial Cox inhibitor is well tolerated, has better Gastrointestinal (GI) tolerability and improved cardiovascular safety when compared with other selective Cox-2 inhibitor.	aceclofenac	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-73
22171305-2	2011	Aceclofenac is superior from other NSAIDs as it has selectivity for Cox-2, a beneficial Cox inhibitor is well tolerated, has better Gastrointestinal (GI) tolerability and improved cardiovascular safety when compared with other selective Cox-2 inhibitor.	aceclofenac	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	237-242
21052844-5	2011	Moreover, selenium also inhibited HG, AGE, HI and H2O2-induced activation of p38 mitogen-activated protein kinase (p38 MAPK), which indicated that the preventive effects of selenium on COX-2 and P-selectin may be associated with p38.	Hydrogen Peroxide	50-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	185-190
21052844-5	2011	Moreover, selenium also inhibited HG, AGE, HI and H2O2-induced activation of p38 mitogen-activated protein kinase (p38 MAPK), which indicated that the preventive effects of selenium on COX-2 and P-selectin may be associated with p38.	Selenium	173-181	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	185-190
21052844-2	2011	The aim of our study was to evaluate whether selenium can also alter high glucose (HG), advanced glycation end products (AGE), high insulin (HI) and H2O2-induced expression of cyclooxygenase (COX)-2 and P-selectin.	Selenium	45-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	176-198
21140284-0	2011	Antiproliferative effects of COX-2 inhibitor celecoxib on human breast cancer cell lines.	Celecoxib	45-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34
21052844-6	2011	Our results indicated that selenium supplementation can reduce HG, AGE, HI and H2O2-induced expression of COX-2 and P-selectin by inhibition of the p38 pathway.	Selenium	27-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-111
21140284-3	2011	Here, we evaluated the antiproliferative activity of celecoxib, a selective COX-2 inhibitor, and its nitro-oxy derivative on human breast cancer cells characterized by low and high COX-2 expression, respectively.	Celecoxib	53-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-81
21052844-2	2011	The aim of our study was to evaluate whether selenium can also alter high glucose (HG), advanced glycation end products (AGE), high insulin (HI) and H2O2-induced expression of cyclooxygenase (COX)-2 and P-selectin.	Glucose	74-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	176-198
21052844-2	2011	The aim of our study was to evaluate whether selenium can also alter high glucose (HG), advanced glycation end products (AGE), high insulin (HI) and H2O2-induced expression of cyclooxygenase (COX)-2 and P-selectin.	Hydrogen Peroxide	149-153	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	176-198
21052844-4	2011	Selenium significantly inhibited HG, AGE, HI and H2O2-induced expression of COX-2 and P-selectin.	Selenium	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-81
21052844-4	2011	Selenium significantly inhibited HG, AGE, HI and H2O2-induced expression of COX-2 and P-selectin.	Hydrogen Peroxide	49-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-81
21052844-5	2011	Moreover, selenium also inhibited HG, AGE, HI and H2O2-induced activation of p38 mitogen-activated protein kinase (p38 MAPK), which indicated that the preventive effects of selenium on COX-2 and P-selectin may be associated with p38.	Selenium	10-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	185-190
21052844-6	2011	Our results indicated that selenium supplementation can reduce HG, AGE, HI and H2O2-induced expression of COX-2 and P-selectin by inhibition of the p38 pathway.	Hydrogen Peroxide	79-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-111
21185865-5	2011	The effects on HCO(3)(-) secretion and PGE(2) production are inhibited by indomethacin [nonselective cyclooxygenase (COX) inhibitor] and SC-560 (selective COX-1 inhibitor) but not rofecoxib (selective COX-2 inhibitor).	Bicarbonates	15-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	201-206
21185865-5	2011	The effects on HCO(3)(-) secretion and PGE(2) production are inhibited by indomethacin [nonselective cyclooxygenase (COX) inhibitor] and SC-560 (selective COX-1 inhibitor) but not rofecoxib (selective COX-2 inhibitor).	Indomethacin	74-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	201-206
21185865-5	2011	The effects on HCO(3)(-) secretion and PGE(2) production are inhibited by indomethacin [nonselective cyclooxygenase (COX) inhibitor] and SC-560 (selective COX-1 inhibitor) but not rofecoxib (selective COX-2 inhibitor).	SC 560	137-143	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	201-206
21376132-3	2011	Human CG induction of immunoreactive COX-2 in the granulosa layer of mature Graafian follicles at hCG8h was reduced by RU486 treatment at hCG0h and trilostane treatment at hCG4h.	Mifepristone	119-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-42
21376132-3	2011	Human CG induction of immunoreactive COX-2 in the granulosa layer of mature Graafian follicles at hCG8h was reduced by RU486 treatment at hCG0h and trilostane treatment at hCG4h.	trilostane	148-158	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-42
21237633-2	2011	The voltammetric behaviour of the modified electrode in 0.1M NaOH shows two different redox couples: Co(II)/Co(III) and Co(III)/Co(IV).	Sodium Hydroxide	61-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-107
21457561-5	2011	RESULTS: Over expression of Core gene of HCV 3a genotype showed stronger effect in regulating RNA and protein levels of Cox-2, iNOS, VEGF, p-Akt as compared to HCV-1a Core in hepatocellular carcinoma cell line Huh-7 accompanied by enhanced PGE2 release and cell proliferation.	Dinoprostone	240-244	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-125
21294523-1	2011	We report the magnetic structure of two of the magnetically ordered phases of Co(3)(OH)(2)(C(4)O(4))(2) 3H(2)O, a coordination polymer that consists of a triangular framework decorated with anisotropic Co(II) ions.	co(3)	78-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	202-208
21239635-7	2011	In cultured human umbilical vein endothelial cells (HUVECs) exposed to elevated glucose (450 mg/dl) or ONOO derived from 3-morpholinosydnonimine (SIN-1), expression of COX-2 was increased and was prevented when endothelial cells were treated with FeTMPyP.	linsidomine	121-144	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	168-173
21332140-0	2011	Enantioselective cyclopropenation of alkynes with acceptor/acceptor-substituted diazo reagents via Co(II)-based metalloradical catalysis.	diazo reagents	80-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-104
21247694-0	2011	Capture of Co(II) from its aqueous EDTA-chelate by DTPA-modified silica gel and chitosan.	Edetic Acid	35-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-17
21247694-0	2011	Capture of Co(II) from its aqueous EDTA-chelate by DTPA-modified silica gel and chitosan.	Pentetic Acid	51-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-17
21247694-0	2011	Capture of Co(II) from its aqueous EDTA-chelate by DTPA-modified silica gel and chitosan.	Silica Gel	65-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-17
21247694-1	2011	The adsorption of Co(II) by diethylenetriaminepentaacetic acid (DTPA)-modified silica gel and chitosan in the presence of EDTA and other interfering species was studied.	Pentetic Acid	28-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-23
21247694-1	2011	The adsorption of Co(II) by diethylenetriaminepentaacetic acid (DTPA)-modified silica gel and chitosan in the presence of EDTA and other interfering species was studied.	Pentetic Acid	64-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-23
21247694-1	2011	The adsorption of Co(II) by diethylenetriaminepentaacetic acid (DTPA)-modified silica gel and chitosan in the presence of EDTA and other interfering species was studied.	Silica Gel	79-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-23
21247694-1	2011	The adsorption of Co(II) by diethylenetriaminepentaacetic acid (DTPA)-modified silica gel and chitosan in the presence of EDTA and other interfering species was studied.	Edetic Acid	122-126	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-23
21247694-2	2011	Co(II) removal ranged from 93% to 96% from the solutions where Co(II) was totally chelated by EDTA.	Edetic Acid	94-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
21247694-2	2011	Co(II) removal ranged from 93% to 96% from the solutions where Co(II) was totally chelated by EDTA.	Edetic Acid	94-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-69
21247694-6	2011	For DTPA-silica gel, the rate of adsorption of free Co(II) was controlled by pore diffusion, but the rate of adsorption of Co(II)EDTA was controlled by the surface chelation reaction, which was attributed to the inhibited diffusion of Co(II)EDTA inside the silica gel mesopores.	Pentetic Acid	4-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-58
21247694-6	2011	For DTPA-silica gel, the rate of adsorption of free Co(II) was controlled by pore diffusion, but the rate of adsorption of Co(II)EDTA was controlled by the surface chelation reaction, which was attributed to the inhibited diffusion of Co(II)EDTA inside the silica gel mesopores.	Pentetic Acid	4-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-57
21247694-6	2011	For DTPA-silica gel, the rate of adsorption of free Co(II) was controlled by pore diffusion, but the rate of adsorption of Co(II)EDTA was controlled by the surface chelation reaction, which was attributed to the inhibited diffusion of Co(II)EDTA inside the silica gel mesopores.	Silica Gel	9-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-58
21247694-6	2011	For DTPA-silica gel, the rate of adsorption of free Co(II) was controlled by pore diffusion, but the rate of adsorption of Co(II)EDTA was controlled by the surface chelation reaction, which was attributed to the inhibited diffusion of Co(II)EDTA inside the silica gel mesopores.	Silica Gel	9-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-57
21247694-6	2011	For DTPA-silica gel, the rate of adsorption of free Co(II) was controlled by pore diffusion, but the rate of adsorption of Co(II)EDTA was controlled by the surface chelation reaction, which was attributed to the inhibited diffusion of Co(II)EDTA inside the silica gel mesopores.	Silicon Dioxide	9-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-58
21247694-6	2011	For DTPA-silica gel, the rate of adsorption of free Co(II) was controlled by pore diffusion, but the rate of adsorption of Co(II)EDTA was controlled by the surface chelation reaction, which was attributed to the inhibited diffusion of Co(II)EDTA inside the silica gel mesopores.	Silicon Dioxide	9-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-57
21247694-7	2011	However, the macroporous structure of DTPA-chitosan enabled pore diffusion of both Co(II) and Co(II)EDTA.	Pentetic Acid	38-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-89
21247694-7	2011	However, the macroporous structure of DTPA-chitosan enabled pore diffusion of both Co(II) and Co(II)EDTA.	Pentetic Acid	38-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
21247694-10	2011	Finally, measurements with capillary electrophoresis showed an increase in dissolved EDTA during adsorption, demonstrating the ability of DTPA-modified adsorbents to release Co(II) from its EDTA chelate.	Edetic Acid	85-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	174-180
21247694-10	2011	Finally, measurements with capillary electrophoresis showed an increase in dissolved EDTA during adsorption, demonstrating the ability of DTPA-modified adsorbents to release Co(II) from its EDTA chelate.	Pentetic Acid	138-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	174-180
21247694-10	2011	Finally, measurements with capillary electrophoresis showed an increase in dissolved EDTA during adsorption, demonstrating the ability of DTPA-modified adsorbents to release Co(II) from its EDTA chelate.	Edetic Acid	190-194	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	174-180
21247694-11	2011	This promising result can provide a basis for applying the studied materials to the treatment of water effluents containing Co(II) chelated by EDTA by a simple one-step adsorption process.	Water	97-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	124-130
21247694-11	2011	This promising result can provide a basis for applying the studied materials to the treatment of water effluents containing Co(II) chelated by EDTA by a simple one-step adsorption process.	Edetic Acid	143-147	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	124-130
21332140-0	2011	Enantioselective cyclopropenation of alkynes with acceptor/acceptor-substituted diazo reagents via Co(II)-based metalloradical catalysis.	Alkynes	37-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-104
21315917-2	2011	Cyclic voltammograms of the modified electrode show a stable and well defined redox couple in alkaline media due to the synergy of Ni(II)/Ni(III) system with Co(II)/Co(III).	Nickel(2+)	131-137	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	158-164
21401943-6	2011	The COX-2 promoter was hypomethylated in HBV-positive cells, and specific demethylation of CpG dinucleotides within each of the two NF-AT sites in the COX-2 promoter resulted in the increased binding affinity of NF-AT to the cognate sites in the promoter, followed by increased COX-2 expression and PGE2 accumulation.	Dinucleoside Phosphates	95-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
21401943-6	2011	The COX-2 promoter was hypomethylated in HBV-positive cells, and specific demethylation of CpG dinucleotides within each of the two NF-AT sites in the COX-2 promoter resulted in the increased binding affinity of NF-AT to the cognate sites in the promoter, followed by increased COX-2 expression and PGE2 accumulation.	Dinucleoside Phosphates	95-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-156
21401943-6	2011	The COX-2 promoter was hypomethylated in HBV-positive cells, and specific demethylation of CpG dinucleotides within each of the two NF-AT sites in the COX-2 promoter resulted in the increased binding affinity of NF-AT to the cognate sites in the promoter, followed by increased COX-2 expression and PGE2 accumulation.	Dinucleoside Phosphates	95-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-156
21401943-6	2011	The COX-2 promoter was hypomethylated in HBV-positive cells, and specific demethylation of CpG dinucleotides within each of the two NF-AT sites in the COX-2 promoter resulted in the increased binding affinity of NF-AT to the cognate sites in the promoter, followed by increased COX-2 expression and PGE2 accumulation.	Dinoprostone	299-303	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
21401943-6	2011	The COX-2 promoter was hypomethylated in HBV-positive cells, and specific demethylation of CpG dinucleotides within each of the two NF-AT sites in the COX-2 promoter resulted in the increased binding affinity of NF-AT to the cognate sites in the promoter, followed by increased COX-2 expression and PGE2 accumulation.	Dinoprostone	299-303	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-156
21401943-6	2011	The COX-2 promoter was hypomethylated in HBV-positive cells, and specific demethylation of CpG dinucleotides within each of the two NF-AT sites in the COX-2 promoter resulted in the increased binding affinity of NF-AT to the cognate sites in the promoter, followed by increased COX-2 expression and PGE2 accumulation.	Dinoprostone	299-303	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-156
21239635-7	2011	In cultured human umbilical vein endothelial cells (HUVECs) exposed to elevated glucose (450 mg/dl) or ONOO derived from 3-morpholinosydnonimine (SIN-1), expression of COX-2 was increased and was prevented when endothelial cells were treated with FeTMPyP.	FeTMPyP	247-254	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	168-173
21077850-7	2011	KEY RESULTS: BA inhibited LPS-induced COX-2 protein expression and prostaglandin E(2) production and also attenuated LPS-induced ERK and Akt phosphorylation, but not p38 in hPBMCs.	betulinic acid	13-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-43
21288716-3	2011	The structure-function relationship shows that the p-hydroxyl group on the alpha-position benzene ring, particularly if acetylated, contributes to the considerable anti-inflammatory activity; that the carboxyl group on the double bond, if esterified, also contributes to the anti-inflammatory activity; that the p-methylsulfonyl group on the other benzene ring, whose introduction is due to the COX-2 selectivity, also contributes to anti-inflammatory activity surprisingly.	Benzene	90-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	395-400
20883815-7	2011	Up-regulation of Cyclin-D1, Cox-2, XIAP and cIAP1 and phosphorylation of MAPKs, were completely inhibited on inactivation of NF-kappaB assigning a key regulatory role to NF-kappaB in the synergistic effect of paclitaxel and curcumin.	Paclitaxel	209-219	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
21265566-1	2011	Scanning transmission X-ray microscopy was used to investigate the speciation and spatial distribution of Co in a Co(II)-doped cement matrix.	Cobalt	106-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-120
21265566-4	2011	Co 2p(3/2) absorption edge signals were used to determine the spatial distributions of the metal species in the Co(II)-doped cement.	co 2p	0-5	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-118
21265566-4	2011	Co 2p(3/2) absorption edge signals were used to determine the spatial distributions of the metal species in the Co(II)-doped cement.	Metals	91-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-118
21265566-6	2011	On the basis of the shape of the absorption spectra, it was found that Co(II) is partly oxidized to Co(III).	co(iii)	100-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-77
21265566-7	2011	The correlation, respectively the anticorrelation with elements such as Al, Si, and Mn, show that Co(II) is predominantly present as Co-hydroxide-like phase as well as Co-phyllosilicate, whereas Co(III) tends to be incorporated only into a CoOOH-like phase.	Aluminum	72-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-104
21265566-7	2011	The correlation, respectively the anticorrelation with elements such as Al, Si, and Mn, show that Co(II) is predominantly present as Co-hydroxide-like phase as well as Co-phyllosilicate, whereas Co(III) tends to be incorporated only into a CoOOH-like phase.	Silicon	76-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-104
21265566-7	2011	The correlation, respectively the anticorrelation with elements such as Al, Si, and Mn, show that Co(II) is predominantly present as Co-hydroxide-like phase as well as Co-phyllosilicate, whereas Co(III) tends to be incorporated only into a CoOOH-like phase.	co-hydroxide	133-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-104
21265566-7	2011	The correlation, respectively the anticorrelation with elements such as Al, Si, and Mn, show that Co(II) is predominantly present as Co-hydroxide-like phase as well as Co-phyllosilicate, whereas Co(III) tends to be incorporated only into a CoOOH-like phase.	co-phyllosilicate	168-185	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-104
21265566-7	2011	The correlation, respectively the anticorrelation with elements such as Al, Si, and Mn, show that Co(II) is predominantly present as Co-hydroxide-like phase as well as Co-phyllosilicate, whereas Co(III) tends to be incorporated only into a CoOOH-like phase.	coooh	240-245	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-104
21265566-8	2011	Thus, this study suggests that thermodynamic calculations of Co(II)-immobilization by cementitious systems should take into consideration not only the solubility of Co(II)-hydroxides but also Co(III) phases.	co(iii)	192-199	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-67
20828867-10	2011	Quercetin mediated reduction of TLR2 and TLR4 expression and the inhibition of nuclear translocation of NF-kappaB p65 in turn decreased the inflammatory enzymes like 5-LOX and COX and also decreased the mRNA expression of inducible enzymes like COX-2 and iNOS.	Quercetin	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	245-250
21372033-7	2011	Saturated fatty acids, which have been linked to obesity-related inflammation, stimulated NF-kappaB activity in macrophages leading to increased levels of TNF-alpha, IL-1beta, and Cox-2, each of which contributed to the induction of aromatase in preadipocytes.	Fatty Acids	0-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	180-185
21147091-5	2011	The expression of COX-2, iNOS, and their products PGE(2) and NO also increased.	Prostaglandins E	50-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-23
20883815-7	2011	Up-regulation of Cyclin-D1, Cox-2, XIAP and cIAP1 and phosphorylation of MAPKs, were completely inhibited on inactivation of NF-kappaB assigning a key regulatory role to NF-kappaB in the synergistic effect of paclitaxel and curcumin.	Curcumin	224-232	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
21106803-6	2011	Similarly, PGE2 production was also enhanced significantly in infected HBCAs and was blocked in the presence of the COX-2-specific inhibitor NS-398, thus suggesting that COX-2, and not COX-1, was the source of the increased PGE2.	Dinoprostone	11-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-121
21106803-6	2011	Similarly, PGE2 production was also enhanced significantly in infected HBCAs and was blocked in the presence of the COX-2-specific inhibitor NS-398, thus suggesting that COX-2, and not COX-1, was the source of the increased PGE2.	Dinoprostone	11-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	170-175
21106803-6	2011	Similarly, PGE2 production was also enhanced significantly in infected HBCAs and was blocked in the presence of the COX-2-specific inhibitor NS-398, thus suggesting that COX-2, and not COX-1, was the source of the increased PGE2.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	141-147	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-121
21106803-6	2011	Similarly, PGE2 production was also enhanced significantly in infected HBCAs and was blocked in the presence of the COX-2-specific inhibitor NS-398, thus suggesting that COX-2, and not COX-1, was the source of the increased PGE2.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	141-147	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	170-175
21106803-6	2011	Similarly, PGE2 production was also enhanced significantly in infected HBCAs and was blocked in the presence of the COX-2-specific inhibitor NS-398, thus suggesting that COX-2, and not COX-1, was the source of the increased PGE2.	Dinoprostone	224-228	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-121
21106803-6	2011	Similarly, PGE2 production was also enhanced significantly in infected HBCAs and was blocked in the presence of the COX-2-specific inhibitor NS-398, thus suggesting that COX-2, and not COX-1, was the source of the increased PGE2.	Dinoprostone	224-228	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	170-175
21106803-9	2011	These results provide direct evidence that WNV-induced COX-2/PGE2 is involved in modulating the expression of multiple neuroinflammatory mediators, thereby directly linking COX-2 with WNV disease pathogenesis.	Dinoprostone	61-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-60
21106803-9	2011	These results provide direct evidence that WNV-induced COX-2/PGE2 is involved in modulating the expression of multiple neuroinflammatory mediators, thereby directly linking COX-2 with WNV disease pathogenesis.	Dinoprostone	61-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	173-178
21106803-10	2011	The ability of COX-2 inhibitors to modulate WNV-induced COX-2 and PGE2 signalling warrants further investigation in an animal model as a potential approach for clinical management of neuroinflammation associated with WNVE.	Dinoprostone	66-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-20
21062351-8	2011	Further, melatonin treatment also reduced the elevated levels of proinflammatory cytokines (TNF-alpha and IL-6), iNOS and COX-2 in sciatic nerves of animals.	Melatonin	9-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-127
21522293-1	2011	In the title diaqua-cobalt complex, [Co(C(8)H(11)NO(5)PS)(2)(H(2)O)(2)], the Co(II) atom is surrounded by six O atoms belonging to the phosphoryl and sulfonyl groups of two deprotonated chelate ligands and two additional O atoms from water mol-ecules which are in cis positions with respect to one another.	Cobalt	20-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-83
21243136-1	2011	In this paper we report the temperature and pH dependent syntheses and systematic characterization of four new Co(II)/Co(III) and Ni(II) complexes with a pentadentate Schiff base ligand H(3)L obtained by condensing 1,3,-diaminopropan-2-ol with 2-hydroxyacetophenone in 1:2 molar ratio.	Nickel(2+)	130-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	111-117
20971568-4	2011	The consumption of (-)-epigallocatechin 3-gallate (EGCG) has been studied extensively as a potential treatment for a variety of carcinogenic and degenerative diseases due to its ability to suppress a variety of inflammatory and angiogenic factors such as NF-kappaB, IL-1beta, COX2, VEGF, and matrix metalloproteinases.	epigallocatechin gallate	19-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	276-280
20971568-4	2011	The consumption of (-)-epigallocatechin 3-gallate (EGCG) has been studied extensively as a potential treatment for a variety of carcinogenic and degenerative diseases due to its ability to suppress a variety of inflammatory and angiogenic factors such as NF-kappaB, IL-1beta, COX2, VEGF, and matrix metalloproteinases.	epigallocatechin gallate	51-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	276-280
21277633-0	2011	IL-4 and IL-13 suppress prostaglandins production in human follicular dendritic cells by repressing COX-2 and mPGES-1 expression through JAK1 and STAT6.	Prostaglandins	24-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-105
21195543-6	2011	Furthermore, we showed that diosgenin alone, TRAIL alone or combination treatment increased COX-2 expression and that the use of a COX-2 inhibitor further increased apoptosis induction.	Diosgenin	28-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-97
21243136-1	2011	In this paper we report the temperature and pH dependent syntheses and systematic characterization of four new Co(II)/Co(III) and Ni(II) complexes with a pentadentate Schiff base ligand H(3)L obtained by condensing 1,3,-diaminopropan-2-ol with 2-hydroxyacetophenone in 1:2 molar ratio.	h(3)l	186-191	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	111-117
21522293-1	2011	In the title diaqua-cobalt complex, [Co(C(8)H(11)NO(5)PS)(2)(H(2)O)(2)], the Co(II) atom is surrounded by six O atoms belonging to the phosphoryl and sulfonyl groups of two deprotonated chelate ligands and two additional O atoms from water mol-ecules which are in cis positions with respect to one another.	co(c(8)h(11)no	37-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-83
21522293-1	2011	In the title diaqua-cobalt complex, [Co(C(8)H(11)NO(5)PS)(2)(H(2)O)(2)], the Co(II) atom is surrounded by six O atoms belonging to the phosphoryl and sulfonyl groups of two deprotonated chelate ligands and two additional O atoms from water mol-ecules which are in cis positions with respect to one another.	Phosphorus	54-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-83
21522293-1	2011	In the title diaqua-cobalt complex, [Co(C(8)H(11)NO(5)PS)(2)(H(2)O)(2)], the Co(II) atom is surrounded by six O atoms belonging to the phosphoryl and sulfonyl groups of two deprotonated chelate ligands and two additional O atoms from water mol-ecules which are in cis positions with respect to one another.	Water	61-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-83
21180730-0	2011	Catalytic dioxygen activation by Co(II) complexes employing a coordinatively versatile ligand scaffold.	Oxygen	10-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-39
21250752-1	2011	To elucidate the active conformation of indometacin that differentiates between cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2), the stereochemistry around the N-benzoylated indole moiety of indometacin was studied.	Indomethacin	40-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	127-132
21210055-0	2011	Redox-active nickel and cobalt tris(pyrazolyl)borate dithiocarbamate complexes: air-stable Co(II) dithiocarbamates.	Nickel	13-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-97
21210055-0	2011	Redox-active nickel and cobalt tris(pyrazolyl)borate dithiocarbamate complexes: air-stable Co(II) dithiocarbamates.	cobalt tris(pyrazolyl)borate dithiocarbamate	24-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-97
21226530-0	2011	Structural, electronic, and theoretical description of a series of cobalt clathrochelate complexes in the Co(III), Co(II) and Co(I) oxidation states.	cobalt clathrochelate	67-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-121
20832511-3	2011	Inhibition of prostaglandin synthesis with the cyclooxygenase (COX) inhibitor indomethacin or the specific COX-2 blocker NS-398 abolished mineralization in the absence and presence of 1 ng/ml of TNF-alpha, suggesting that PGs were involved.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	121-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-112
21078540-5	2011	The mechanism is at least partially due to the suppressive effect of genistein both on the proper and ATO-induced Akt activation, and on the activity of NF-kappaB, and the latter correlated with the suppression of NF-kappaB regulated gene products, including cyclin D1, Bcl-xL, Bcl-2, c-myc, COX-2, and VEGF.	Genistein	69-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	292-297
21199169-5	2011	Numerous anticancer drugs, such as tamoxifen, COX-2 inhibitors, and retinoids were used for the experiments, and the combination of EGCG and COX-2 inhibitors consistently induced the enhancement of apoptosis.	Tamoxifen	35-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	141-146
21199169-5	2011	Numerous anticancer drugs, such as tamoxifen, COX-2 inhibitors, and retinoids were used for the experiments, and the combination of EGCG and COX-2 inhibitors consistently induced the enhancement of apoptosis.	Retinoids	68-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	141-146
21199169-5	2011	Numerous anticancer drugs, such as tamoxifen, COX-2 inhibitors, and retinoids were used for the experiments, and the combination of EGCG and COX-2 inhibitors consistently induced the enhancement of apoptosis.	epigallocatechin gallate	132-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
20491534-8	2011	PFF stimulated NO and PGE2 production, and up-regulated COX-2 but not COX-1 gene expression.	p-Fluorophenylalanine	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-61
21125642-7	2011	PK or Ro had no effect on LPS-induced increase of pro-inflammatory genes, but they both decreased the ATP-induced increase of COX-2 gene expression.	Adenosine Triphosphate	102-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-131
21067863-5	2011	Interestingly, the pro-apoptotic effects of combined niflumic acid-ciglitazone treatment were realized through Cox-2- and PPARgamma-independent mechanisms.	Niflumic Acid	53-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	111-116
21132266-6	2011	Furthermore, LJGP treatment also caused a progressive decrease in the expression levels of cyclooxygenase (COX)-2 without significant changes in the levels of COX-1, which was correlated with a decrease in prostaglandin E2 synthesis.	ljgp	13-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-113
21181286-2	2011	COX-2 inhibitors and NSAIDs act by inhibiting arachidonic acid metabolism to prostaglandins.	Arachidonic Acid	46-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
21181286-2	2011	COX-2 inhibitors and NSAIDs act by inhibiting arachidonic acid metabolism to prostaglandins.	Prostaglandins	77-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
20376700-2	2011	We found that in AN(3)CA and F9 cells, this hCOX-2 DR1 mediates responsiveness to all-trans-retinoic acid (tRA) or 9-cis-retinoic acid (9cRA), but this effect was suppressed by PPARdelta.	Tretinoin	82-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-50
20376700-2	2011	We found that in AN(3)CA and F9 cells, this hCOX-2 DR1 mediates responsiveness to all-trans-retinoic acid (tRA) or 9-cis-retinoic acid (9cRA), but this effect was suppressed by PPARdelta.	Tretinoin	107-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-50
20376700-2	2011	We found that in AN(3)CA and F9 cells, this hCOX-2 DR1 mediates responsiveness to all-trans-retinoic acid (tRA) or 9-cis-retinoic acid (9cRA), but this effect was suppressed by PPARdelta.	Alitretinoin	115-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-50
20376700-2	2011	We found that in AN(3)CA and F9 cells, this hCOX-2 DR1 mediates responsiveness to all-trans-retinoic acid (tRA) or 9-cis-retinoic acid (9cRA), but this effect was suppressed by PPARdelta.	Alitretinoin	136-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-50
20376700-3	2011	Truncated PPARdelta lacking the activation domain AF2 cannot suppress RA-induced activation of the hCOX-2 gene via DR1, suggesting that cofactor recruitment by AF2 is required for the suppression by PPARdelta.	Radium	70-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-105
20713430-0	2011	Food contaminant acrylamide increases expression of Cox-2 and nitric oxide synthase in breast epithelial cells.	Acrylamide	17-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-57
20713430-4	2011	Treatment of cells with acrylamide increased levels of iNOS (both expression and activity) and Cox-2.	Acrylamide	24-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-100
20713430-5	2011	Its potent metabolite, glycidamide, also induced both iNOS and Cox-2, with induction of iNOS occurring at a lower concentration.	glycidamide	23-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-68
20713430-6	2011	2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), another food-borne carcinogen, was found to induce Cox-2 expression.	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	0-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-112
20713430-6	2011	2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), another food-borne carcinogen, was found to induce Cox-2 expression.	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	49-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-112
21067863-0	2011	Combined treatment with the Cox-2 inhibitor niflumic acid and PPARgamma ligand ciglitazone induces ER stress/caspase-8-mediated apoptosis in human lung cancer cells.	Niflumic Acid	44-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
21067863-0	2011	Combined treatment with the Cox-2 inhibitor niflumic acid and PPARgamma ligand ciglitazone induces ER stress/caspase-8-mediated apoptosis in human lung cancer cells.	ciglitazone	79-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
21067863-1	2011	The present study was performed to investigate the possible combined use of the Cox-2 inhibitor niflumic acid and the PPARgamma ligand ciglitazone and to elucidate the mechanisms underlying enhanced apoptosis by this combination treatment in human lung cancer cells.	Niflumic Acid	96-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-85
21140006-9	2011	Moreover, magnetic susceptibility measurement of 5 indicates the presence of weak ferromagnetic interactions between the Co(II) ions bridged by carboxylate groups.	carboxylate	144-155	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-127
21152624-4	2011	[Co(II)-L(2)-Ln(III)] (18-25) series exhibit 2D open frameworks based on double-stranded helical motifs, which are further assembled into 3D porous structures by intermolecular hydrogen bonds between hydroxyl groups.	Hydrogen	177-185	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	1-7
21152624-4	2011	[Co(II)-L(2)-Ln(III)] (18-25) series exhibit 2D open frameworks based on double-stranded helical motifs, which are further assembled into 3D porous structures by intermolecular hydrogen bonds between hydroxyl groups.	Hydroxyl Radical	200-208	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	1-7
21152624-9	2011	For the single ion behavior of Co(II) and Ln(III) ions, the magnetic coupling nature between Fe(II)(HS)/Co(II) and Ln(III) ions cannot be clearly depicted as antiferromagnetic coupling.	ammonium ferrous sulfate	93-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-37
21112970-3	2011	Perinuclear L-PGDS/Arr3 co-localization is observed in PGD(2)-producing MG-63 cells and is induced by the addition of the L-PGDS substrate or co-expression of COX-2 in HEK293 cells.	Prostaglandin D2	55-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	159-164
21127821-6	2011	The two-dimensional ferrimagnetic system [Me(4)N](2n){Co(2)[Cu(dmopba)](3)}(n) 4nDMSO nH(2)O (3) was prepared by reaction of Co(II) ions and an excess of [Cu(dmopba)](2-) in DMSO.	me(4)n](2n)	42-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-131
21127821-6	2011	The two-dimensional ferrimagnetic system [Me(4)N](2n){Co(2)[Cu(dmopba)](3)}(n) 4nDMSO nH(2)O (3) was prepared by reaction of Co(II) ions and an excess of [Cu(dmopba)](2-) in DMSO.	cu(dmopba)](3)}(n) 4ndmso nh(2)o (3)	60-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-131
21127821-6	2011	The two-dimensional ferrimagnetic system [Me(4)N](2n){Co(2)[Cu(dmopba)](3)}(n) 4nDMSO nH(2)O (3) was prepared by reaction of Co(II) ions and an excess of [Cu(dmopba)](2-) in DMSO.	cu(dmopba)	60-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-131
21142119-7	2011	The results show that while the sterics of the cis-14-TMC chelate contribute to the geometry of O2 binding and result in an end-on-bound Ni(II)O2(-) complex in [(14-TMC)NiO2](+), the higher thermodynamic driving force for oxidation of Co(II) overcomes this steric constraint, resulting in stabilization of a side-on-bound Co(III)O2(2-) electronic structure in 2.	cis-14-tmc	47-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	235-241
21142119-7	2011	The results show that while the sterics of the cis-14-TMC chelate contribute to the geometry of O2 binding and result in an end-on-bound Ni(II)O2(-) complex in [(14-TMC)NiO2](+), the higher thermodynamic driving force for oxidation of Co(II) overcomes this steric constraint, resulting in stabilization of a side-on-bound Co(III)O2(2-) electronic structure in 2.	ni(ii)o2	137-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	235-241
21142119-7	2011	The results show that while the sterics of the cis-14-TMC chelate contribute to the geometry of O2 binding and result in an end-on-bound Ni(II)O2(-) complex in [(14-TMC)NiO2](+), the higher thermodynamic driving force for oxidation of Co(II) overcomes this steric constraint, resulting in stabilization of a side-on-bound Co(III)O2(2-) electronic structure in 2.	(14-tmc)nio2	161-173	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	235-241
21522869-1	2011	In the title complex, [Co(NCS)(2)(C(13)H(19)N(3)O)(H(2)O)], the Co(II) ion is six-coordinated by the N,N",N""-tridentate Schiff base, the N atoms of two thio-cyanate ligands and one water mol-ecule in a distorted octa-hedral geometry.	hippuric acid	52-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-70
21522869-1	2011	In the title complex, [Co(NCS)(2)(C(13)H(19)N(3)O)(H(2)O)], the Co(II) ion is six-coordinated by the N,N",N""-tridentate Schiff base, the N atoms of two thio-cyanate ligands and one water mol-ecule in a distorted octa-hedral geometry.	Nitrogen	26-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-70
21522869-1	2011	In the title complex, [Co(NCS)(2)(C(13)H(19)N(3)O)(H(2)O)], the Co(II) ion is six-coordinated by the N,N",N""-tridentate Schiff base, the N atoms of two thio-cyanate ligands and one water mol-ecule in a distorted octa-hedral geometry.	Nitrogen	103-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-70
21522869-1	2011	In the title complex, [Co(NCS)(2)(C(13)H(19)N(3)O)(H(2)O)], the Co(II) ion is six-coordinated by the N,N",N""-tridentate Schiff base, the N atoms of two thio-cyanate ligands and one water mol-ecule in a distorted octa-hedral geometry.	Schiff Bases	121-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-70
21522869-1	2011	In the title complex, [Co(NCS)(2)(C(13)H(19)N(3)O)(H(2)O)], the Co(II) ion is six-coordinated by the N,N",N""-tridentate Schiff base, the N atoms of two thio-cyanate ligands and one water mol-ecule in a distorted octa-hedral geometry.	Nitrogen	44-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-70
21522869-1	2011	In the title complex, [Co(NCS)(2)(C(13)H(19)N(3)O)(H(2)O)], the Co(II) ion is six-coordinated by the N,N",N""-tridentate Schiff base, the N atoms of two thio-cyanate ligands and one water mol-ecule in a distorted octa-hedral geometry.	thiocyanate	153-165	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-70
21522869-1	2011	In the title complex, [Co(NCS)(2)(C(13)H(19)N(3)O)(H(2)O)], the Co(II) ion is six-coordinated by the N,N",N""-tridentate Schiff base, the N atoms of two thio-cyanate ligands and one water mol-ecule in a distorted octa-hedral geometry.	Water	182-187	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-70
21522869-1	2011	In the title complex, [Co(NCS)(2)(C(13)H(19)N(3)O)(H(2)O)], the Co(II) ion is six-coordinated by the N,N",N""-tridentate Schiff base, the N atoms of two thio-cyanate ligands and one water mol-ecule in a distorted octa-hedral geometry.	octa-hedral	213-224	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-70
20933508-3	2011	Arzanol inhibited 5-lipoxygenase (EC 7.13.11.34) activity and related leukotriene formation in neutrophils, as well as the activity of cyclooxygenase (COX)-1 (EC 1.14.99.1) and the formation of COX-2-derived prostaglandin (PG)E(2)in vitro (IC(50)=2.3-9muM).	arzanol	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	194-199
20933508-5	2011	In fact, arzanol could block COX-2/mPGES-1-mediated PGE(2) biosynthesis in lipopolysaccharide-stimulated human monocytes and human whole blood, but not the concomitant COX-2-derived biosynthesis of thromboxane B(2) or of 6-keto PGF(1alpha), and the expression of COX-2 or mPGES-1 protein was not affected.	arzanol	9-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34
20933508-5	2011	In fact, arzanol could block COX-2/mPGES-1-mediated PGE(2) biosynthesis in lipopolysaccharide-stimulated human monocytes and human whole blood, but not the concomitant COX-2-derived biosynthesis of thromboxane B(2) or of 6-keto PGF(1alpha), and the expression of COX-2 or mPGES-1 protein was not affected.	Dinoprostone	52-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34
21232092-3	2011	In THP-1 macrophages, MTX can promote the reversal of cholesterol transport, limit foam cell formation and also reverse COX-2 inhibitor-mediated downregulation of ABCA1.	Methotrexate	22-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-125
21214962-1	2011	BACKGROUND: COX-2 is an enzyme isoform that catalyses the formation of prostanoids from arachidonic acid.	Prostaglandins	71-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-17
21214962-1	2011	BACKGROUND: COX-2 is an enzyme isoform that catalyses the formation of prostanoids from arachidonic acid.	Arachidonic Acid	88-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-17
20817448-1	2011	Because cyclooxygenases (COX) convert arachidonic acid into pro-inflammatory cyclic endoperoxides, inhibition of these enzymes and especially the inducible COX-2 form is an important therapeutic approach to manage inflammatory diseases and possibly prevent cancer.	Arachidonic Acid	38-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	156-161
20817448-1	2011	Because cyclooxygenases (COX) convert arachidonic acid into pro-inflammatory cyclic endoperoxides, inhibition of these enzymes and especially the inducible COX-2 form is an important therapeutic approach to manage inflammatory diseases and possibly prevent cancer.	cyclic endoperoxides	77-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	156-161
20817448-4	2011	The assay was validated using four COX inhibitors, celecoxib, indomethacin, resveratrol, and diclofenac that exhibit different selectivities towards COX-1 and COX-2.	Celecoxib	51-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	159-164
20817448-4	2011	The assay was validated using four COX inhibitors, celecoxib, indomethacin, resveratrol, and diclofenac that exhibit different selectivities towards COX-1 and COX-2.	Indomethacin	62-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	159-164
20817448-4	2011	The assay was validated using four COX inhibitors, celecoxib, indomethacin, resveratrol, and diclofenac that exhibit different selectivities towards COX-1 and COX-2.	Resveratrol	76-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	159-164
20817448-4	2011	The assay was validated using four COX inhibitors, celecoxib, indomethacin, resveratrol, and diclofenac that exhibit different selectivities towards COX-1 and COX-2.	Diclofenac	93-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	159-164
20817448-5	2011	The IC(50) values of celecoxib and resveratrol for ovine and human COX-2 were compared, and the K(m) values were determined.	Celecoxib	21-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-72
20817448-5	2011	The IC(50) values of celecoxib and resveratrol for ovine and human COX-2 were compared, and the K(m) values were determined.	Resveratrol	35-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-72
21173056-7	2011	It was also found that quercetin inhibited the expression of the cycloocygenase-2 (Cox-2) mRNA and Cox-2 protein.	Quercetin	23-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
21173056-7	2011	It was also found that quercetin inhibited the expression of the cycloocygenase-2 (Cox-2) mRNA and Cox-2 protein.	Quercetin	23-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-104
21173056-8	2011	Taken together, these findings suggested that quercetin induces apoptosis in a caspase-3-dependent pathway by inhibiting Cox-2 expression and regulates the expression of downstream apoptotic components, including Bcl-2 and Bax.	Quercetin	46-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-126
21206074-1	2011	The Co(II) ion in the title complex salt, [Co(H(2)O)(6)](C(14)H(13)O(10)P(2))(2) 2H(2)O or [Co(H(2)O)(6)][H(C(7)H(6)O(5)P)(2)] 2H(2)O, resides on an inversion centre and exhibits an octahedral environment formed by six aqua ligands.	Salts	36-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
21206074-1	2011	The Co(II) ion in the title complex salt, [Co(H(2)O)(6)](C(14)H(13)O(10)P(2))(2) 2H(2)O or [Co(H(2)O)(6)][H(C(7)H(6)O(5)P)(2)] 2H(2)O, resides on an inversion centre and exhibits an octahedral environment formed by six aqua ligands.	co(h(2)o)	43-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
21206074-1	2011	The Co(II) ion in the title complex salt, [Co(H(2)O)(6)](C(14)H(13)O(10)P(2))(2) 2H(2)O or [Co(H(2)O)(6)][H(C(7)H(6)O(5)P)(2)] 2H(2)O, resides on an inversion centre and exhibits an octahedral environment formed by six aqua ligands.	) 2h(2)o	79-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
21206074-1	2011	The Co(II) ion in the title complex salt, [Co(H(2)O)(6)](C(14)H(13)O(10)P(2))(2) 2H(2)O or [Co(H(2)O)(6)][H(C(7)H(6)O(5)P)(2)] 2H(2)O, resides on an inversion centre and exhibits an octahedral environment formed by six aqua ligands.	co(h(2)o)	92-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
21206074-1	2011	The Co(II) ion in the title complex salt, [Co(H(2)O)(6)](C(14)H(13)O(10)P(2))(2) 2H(2)O or [Co(H(2)O)(6)][H(C(7)H(6)O(5)P)(2)] 2H(2)O, resides on an inversion centre and exhibits an octahedral environment formed by six aqua ligands.	6)o(5)p)(2)] 2h	114-129	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
20920611-6	2011	Aspirin (ASA) converts cyclooxygenase (COX)-2 into a form that generates new neuroprotective docosanoids from DHA; therefore, ASA might positively resolve the paradoxical effect of the concomitant presence of DHA and betaA.	Aspirin	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-45
20920611-6	2011	Aspirin (ASA) converts cyclooxygenase (COX)-2 into a form that generates new neuroprotective docosanoids from DHA; therefore, ASA might positively resolve the paradoxical effect of the concomitant presence of DHA and betaA.	Aspirin	9-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-45
20920611-6	2011	Aspirin (ASA) converts cyclooxygenase (COX)-2 into a form that generates new neuroprotective docosanoids from DHA; therefore, ASA might positively resolve the paradoxical effect of the concomitant presence of DHA and betaA.	docosanoids	93-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-45
20920611-6	2011	Aspirin (ASA) converts cyclooxygenase (COX)-2 into a form that generates new neuroprotective docosanoids from DHA; therefore, ASA might positively resolve the paradoxical effect of the concomitant presence of DHA and betaA.	dehydroacetic acid	110-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-45
20920611-6	2011	Aspirin (ASA) converts cyclooxygenase (COX)-2 into a form that generates new neuroprotective docosanoids from DHA; therefore, ASA might positively resolve the paradoxical effect of the concomitant presence of DHA and betaA.	Aspirin	126-129	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-45
20920611-6	2011	Aspirin (ASA) converts cyclooxygenase (COX)-2 into a form that generates new neuroprotective docosanoids from DHA; therefore, ASA might positively resolve the paradoxical effect of the concomitant presence of DHA and betaA.	dehydroacetic acid	209-212	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-45
20920611-6	2011	Aspirin (ASA) converts cyclooxygenase (COX)-2 into a form that generates new neuroprotective docosanoids from DHA; therefore, ASA might positively resolve the paradoxical effect of the concomitant presence of DHA and betaA.	betaa	217-222	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-45
21261644-5	2011	By a PD98059-inhibitable process, resveratrol causes inducible COX-2 to accumulate in the nucleus where it complexes with pERK1/2 and p53.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	5-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-68
21261644-5	2011	By a PD98059-inhibitable process, resveratrol causes inducible COX-2 to accumulate in the nucleus where it complexes with pERK1/2 and p53.	Resveratrol	34-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-68
21261644-7	2011	NS-398, a specific pharmacologic inhibitor of COX-2, prevents resveratrol-induced complexing of nuclear ERK1/2 with COX-2 and with pSer-15-p53 and subsequent apoptosis; cyclooxygenase enzyme activity is not involved.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	0-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
21261644-7	2011	NS-398, a specific pharmacologic inhibitor of COX-2, prevents resveratrol-induced complexing of nuclear ERK1/2 with COX-2 and with pSer-15-p53 and subsequent apoptosis; cyclooxygenase enzyme activity is not involved.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	0-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-121
21261644-7	2011	NS-398, a specific pharmacologic inhibitor of COX-2, prevents resveratrol-induced complexing of nuclear ERK1/2 with COX-2 and with pSer-15-p53 and subsequent apoptosis; cyclooxygenase enzyme activity is not involved.	Resveratrol	62-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
21261644-7	2011	NS-398, a specific pharmacologic inhibitor of COX-2, prevents resveratrol-induced complexing of nuclear ERK1/2 with COX-2 and with pSer-15-p53 and subsequent apoptosis; cyclooxygenase enzyme activity is not involved.	Resveratrol	62-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-121
21261644-8	2011	Molecular steps in the pro-apoptotic action of resveratrol in cancer cells include induction of intranuclear COX-2 accumulation relevant to activation of p53.	Resveratrol	47-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-114
21955617-3	2011	Besides its anti-inflammatory properties, evidence is accumulating that celecoxib, one of the selective COX-2 inhibitors, has additional disease-modifying effects.	Celecoxib	72-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
21955617-5	2011	As well as COX-2 inhibition, evidence indicates that celecoxib also modulates COX-2-independent signal transduction pathways.	Celecoxib	53-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-16
21955617-5	2011	As well as COX-2 inhibition, evidence indicates that celecoxib also modulates COX-2-independent signal transduction pathways.	Celecoxib	53-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-83
21804201-2	2011	Nonsteroidal anti-inflammatory drugs (NSAIDs), inhibitors of COX-1 and/or COX-2, suppress inflammatory pain by reducing generation of prostanoids, mainly PGE(2), while they exhibit gastrointestinal, renal and cardiovascular toxicities.	Prostaglandins	134-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
21804201-2	2011	Nonsteroidal anti-inflammatory drugs (NSAIDs), inhibitors of COX-1 and/or COX-2, suppress inflammatory pain by reducing generation of prostanoids, mainly PGE(2), while they exhibit gastrointestinal, renal and cardiovascular toxicities.	Prostaglandins E	154-157	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
20974686-3	2011	Using an in vitro cell migration assay, we show that over expression of cyclooxygenase (COX)-2, its metabolite prostaglandin E2 (PGE2) and PGE2 receptors promote the migration of cells.	Dinoprostone	111-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-94
20974686-3	2011	Using an in vitro cell migration assay, we show that over expression of cyclooxygenase (COX)-2, its metabolite prostaglandin E2 (PGE2) and PGE2 receptors promote the migration of cells.	Dinoprostone	129-133	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-94
20974686-4	2011	We found that treatment of A375 and Hs294 cells with berberine resulted in concentration-dependent inhibition of migration of these cells, which was associated with a reduction in the levels of COX-2, PGE2 and PGE2 receptors (EP2 and EP4).	Berberine	53-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	194-199
20974686-5	2011	Treatment of cells with celecoxib, a COX-2 inhibitor, or transient transfection of cells with COX-2 small interfering RNA, also inhibited cell migration.	Celecoxib	24-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-42
20974686-6	2011	Treatment of the cells with 12-O-tetradecanoylphorbol-13-acetate (TPA), an inducer of COX-2 or PGE2, enhanced cell migration, whereas berberine inhibited TPA- or PGE2-promoted cell migration.	Tetradecanoylphorbol Acetate	28-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-91
20974686-6	2011	Treatment of the cells with 12-O-tetradecanoylphorbol-13-acetate (TPA), an inducer of COX-2 or PGE2, enhanced cell migration, whereas berberine inhibited TPA- or PGE2-promoted cell migration.	Tetradecanoylphorbol Acetate	66-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-91
20974686-9	2011	Moreover, berberine inhibited the activation of nuclear factor-kappa B (NF-kappaB), an upstream regulator of COX-2, in A375 cells, and treatment of cells with caffeic acid phenethyl ester, an inhibitor of NF-kappaB, inhibited cell migration.	Berberine	10-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-114
20974686-10	2011	Together, these results indicate for the first time that berberine inhibits melanoma cell migration, an essential step in invasion and metastasis, by inhibition of COX-2, PGE2 and PGE2 receptors.	Berberine	57-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	164-169
21084865-1	2011	Celecoxib is a drug designed to selectively inhibit COX-2, an inflammation-inducible cyclooxygenase isoform, over the constitutively expressed COX-1 isoform.	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-57
21548865-6	2011	This review was designed to provide an updated overview based on the experimental and clinical evidence on the involvement COX-2 derived products, lipoxins in the mechanism of gastric defense, gastroprotection and gastric adaptation to ASA.	Aspirin	236-239	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-128
21548865-9	2011	Aspirin-triggered lipoxin (ATL) synthesis, via COX-2, acts to reduce the severity of damage induced by this NSAID.	Aspirin	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
21548865-9	2011	Aspirin-triggered lipoxin (ATL) synthesis, via COX-2, acts to reduce the severity of damage induced by this NSAID.	Lipoxins	18-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
21548865-12	2011	Suppression of COX-2 activity by selective COX-2 inhibitors such as rofecoxib or celecoxib was shown to abolish the production of ATL and to diminish the gastric tolerability of ASA and gastric adaptation developed in response to repetitive administration of this NSAID.	rofecoxib	68-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-20
21548865-12	2011	Suppression of COX-2 activity by selective COX-2 inhibitors such as rofecoxib or celecoxib was shown to abolish the production of ATL and to diminish the gastric tolerability of ASA and gastric adaptation developed in response to repetitive administration of this NSAID.	rofecoxib	68-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
21548865-12	2011	Suppression of COX-2 activity by selective COX-2 inhibitors such as rofecoxib or celecoxib was shown to abolish the production of ATL and to diminish the gastric tolerability of ASA and gastric adaptation developed in response to repetitive administration of this NSAID.	Celecoxib	81-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-20
21548865-12	2011	Suppression of COX-2 activity by selective COX-2 inhibitors such as rofecoxib or celecoxib was shown to abolish the production of ATL and to diminish the gastric tolerability of ASA and gastric adaptation developed in response to repetitive administration of this NSAID.	Celecoxib	81-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
21548865-12	2011	Suppression of COX-2 activity by selective COX-2 inhibitors such as rofecoxib or celecoxib was shown to abolish the production of ATL and to diminish the gastric tolerability of ASA and gastric adaptation developed in response to repetitive administration of this NSAID.	Aspirin	178-181	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-20
21548865-12	2011	Suppression of COX-2 activity by selective COX-2 inhibitors such as rofecoxib or celecoxib was shown to abolish the production of ATL and to diminish the gastric tolerability of ASA and gastric adaptation developed in response to repetitive administration of this NSAID.	Aspirin	178-181	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
21625419-0	2011	Flavonoids targeting of IkappaB phosphorylation abrogates carcinogen-induced MMP-9 and COX-2 expression in human brain endothelial cells.	Flavonoids	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-92
21625419-5	2011	Human brain microvascular endothelial cells were treated with a combination of phorbol 12-myristate 13-acetate (PMA), a carcinogen documented to increase MMP-9 and COX-2 through NF-kappaB, and several naturally occurring flavonoids.	Tetradecanoylphorbol Acetate	79-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	164-169
21148739-5	2011	Use of pharmacological inhibitors suggested that the modulation in the expression of COX-2 and thereby the levels of PGE(2) and PGD(2) in endothelial cells by Ln is mediated through the alpha(6)beta(4) integrin-p38MAPK (mitogen-activated protein kinase)-NF-kappaB signaling pathway.	Prostaglandins E	117-120	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-90
21148739-5	2011	Use of pharmacological inhibitors suggested that the modulation in the expression of COX-2 and thereby the levels of PGE(2) and PGD(2) in endothelial cells by Ln is mediated through the alpha(6)beta(4) integrin-p38MAPK (mitogen-activated protein kinase)-NF-kappaB signaling pathway.	Prostaglandins D	128-131	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-90
21163799-0	2011	Only a small reduction in morphine use with adding NSAIDs, paracetamol or COX-2 inhibitors to patient controlled morphine in the 24 h after major surgery.	Morphine	26-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
21760774-2	2011	Besides, PGE(2), a product of COX-2, was also under research as to whether it is involved in the upregulation of MMP-9 expression by COX-2.	Prostaglandins E	9-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-35
21760774-2	2011	Besides, PGE(2), a product of COX-2, was also under research as to whether it is involved in the upregulation of MMP-9 expression by COX-2.	Prostaglandins E	9-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	133-138
21760774-6	2011	The upregulation of MMP-9 by TNF-alpha or LPS was inhibited by COX-2 inhibitor NS398.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	79-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-68
21968189-9	2011	Moreover, CIMP+ was significantly correlated with methylation of P16 and COX-2 (r = 0.673 and 0.662, respectively; p &lt; 0.001).	cimp+	10-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-78
21968189-11	2011	COX-2 is a good representative gene of CIMP+ in this cancer.	cimp+	39-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
21243136-1	2011	In this paper we report the temperature and pH dependent syntheses and systematic characterization of four new Co(II)/Co(III) and Ni(II) complexes with a pentadentate Schiff base ligand H(3)L obtained by condensing 1,3,-diaminopropan-2-ol with 2-hydroxyacetophenone in 1:2 molar ratio.	pentadentate schiff base	154-178	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	111-117
21243136-1	2011	In this paper we report the temperature and pH dependent syntheses and systematic characterization of four new Co(II)/Co(III) and Ni(II) complexes with a pentadentate Schiff base ligand H(3)L obtained by condensing 1,3,-diaminopropan-2-ol with 2-hydroxyacetophenone in 1:2 molar ratio.	1,3,-diaminopropan-2-ol	215-238	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	111-117
21243136-1	2011	In this paper we report the temperature and pH dependent syntheses and systematic characterization of four new Co(II)/Co(III) and Ni(II) complexes with a pentadentate Schiff base ligand H(3)L obtained by condensing 1,3,-diaminopropan-2-ol with 2-hydroxyacetophenone in 1:2 molar ratio.	2'-hydroxyacetophenone	244-265	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	111-117
21522824-1	2011	In the title coordination polymer, [Co(C(14)H(16)O(6))(H(2)O)(2)](n), the Co(II) ion, situated on a twofold rotation axis, is coordinated by four O atoms from two 4,4"-[1,4-phenyl-enebis(-oxy)]dibutano-ate (L) ligands and two water mol-ecules in a highly distorted octa-hedral geometry.	Polymers	26-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-80
21522824-1	2011	In the title coordination polymer, [Co(C(14)H(16)O(6))(H(2)O)(2)](n), the Co(II) ion, situated on a twofold rotation axis, is coordinated by four O atoms from two 4,4"-[1,4-phenyl-enebis(-oxy)]dibutano-ate (L) ligands and two water mol-ecules in a highly distorted octa-hedral geometry.	Cobalt	36-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-80
21522824-1	2011	In the title coordination polymer, [Co(C(14)H(16)O(6))(H(2)O)(2)](n), the Co(II) ion, situated on a twofold rotation axis, is coordinated by four O atoms from two 4,4"-[1,4-phenyl-enebis(-oxy)]dibutano-ate (L) ligands and two water mol-ecules in a highly distorted octa-hedral geometry.	Carbon	36-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-80
21522824-1	2011	In the title coordination polymer, [Co(C(14)H(16)O(6))(H(2)O)(2)](n), the Co(II) ion, situated on a twofold rotation axis, is coordinated by four O atoms from two 4,4"-[1,4-phenyl-enebis(-oxy)]dibutano-ate (L) ligands and two water mol-ecules in a highly distorted octa-hedral geometry.	4,4"-[1,4-phenyl-enebis(-oxy)]dibutano-ate	163-205	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-80
21522824-1	2011	In the title coordination polymer, [Co(C(14)H(16)O(6))(H(2)O)(2)](n), the Co(II) ion, situated on a twofold rotation axis, is coordinated by four O atoms from two 4,4"-[1,4-phenyl-enebis(-oxy)]dibutano-ate (L) ligands and two water mol-ecules in a highly distorted octa-hedral geometry.	Water	226-231	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-80
21522824-1	2011	In the title coordination polymer, [Co(C(14)H(16)O(6))(H(2)O)(2)](n), the Co(II) ion, situated on a twofold rotation axis, is coordinated by four O atoms from two 4,4"-[1,4-phenyl-enebis(-oxy)]dibutano-ate (L) ligands and two water mol-ecules in a highly distorted octa-hedral geometry.	CDTA	265-269	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-80
21522824-1	2011	In the title coordination polymer, [Co(C(14)H(16)O(6))(H(2)O)(2)](n), the Co(II) ion, situated on a twofold rotation axis, is coordinated by four O atoms from two 4,4"-[1,4-phenyl-enebis(-oxy)]dibutano-ate (L) ligands and two water mol-ecules in a highly distorted octa-hedral geometry.	hedral	270-276	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-80
21121690-0	2011	Synthesis, crystal structure, and electron paramagnetic resonance investigations of heteronuclear Co(II)/Zn(II) and Co(II)/Cd(II) coordination polymers.	Zinc	105-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-104
21121690-0	2011	Synthesis, crystal structure, and electron paramagnetic resonance investigations of heteronuclear Co(II)/Zn(II) and Co(II)/Cd(II) coordination polymers.	cd(ii)	123-129	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-122
21121690-1	2011	The crystal structures of five new Co(II), Zn(II), and Cd(II) coordination polymers based on pyridine-substituted triazolyl carboxylates are reported.	cd(ii)	55-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-41
21121690-1	2011	The crystal structures of five new Co(II), Zn(II), and Cd(II) coordination polymers based on pyridine-substituted triazolyl carboxylates are reported.	pyridine-substituted triazolyl carboxylates	93-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-41
21121690-3	2011	In order to obtain heteronuclear compounds, we synthesized Co(II)-substituted Zn(II) and Cd(II) coordination polymers.	Zinc	78-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
21121690-3	2011	In order to obtain heteronuclear compounds, we synthesized Co(II)-substituted Zn(II) and Cd(II) coordination polymers.	cd(ii)	89-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
21121690-4	2011	At T = 5 K, the powder samples of the diamagnetically diluted Co(II)/Zn(II) and Co(II)/Cd(II) systems [Co/(Zn,Cd)   0.01] show intense electron paramagnetic resonance spectra, which were analyzed with an effective spin of S" = 1/2.	Zinc	69-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-68
21121690-4	2011	At T = 5 K, the powder samples of the diamagnetically diluted Co(II)/Zn(II) and Co(II)/Cd(II) systems [Co/(Zn,Cd)   0.01] show intense electron paramagnetic resonance spectra, which were analyzed with an effective spin of S" = 1/2.	cd(ii)	87-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-86
21121690-4	2011	At T = 5 K, the powder samples of the diamagnetically diluted Co(II)/Zn(II) and Co(II)/Cd(II) systems [Co/(Zn,Cd)   0.01] show intense electron paramagnetic resonance spectra, which were analyzed with an effective spin of S" = 1/2.	Zinc	106-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-68
21121690-4	2011	At T = 5 K, the powder samples of the diamagnetically diluted Co(II)/Zn(II) and Co(II)/Cd(II) systems [Co/(Zn,Cd)   0.01] show intense electron paramagnetic resonance spectra, which were analyzed with an effective spin of S" = 1/2.	Zinc	106-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-86
21121690-4	2011	At T = 5 K, the powder samples of the diamagnetically diluted Co(II)/Zn(II) and Co(II)/Cd(II) systems [Co/(Zn,Cd)   0.01] show intense electron paramagnetic resonance spectra, which were analyzed with an effective spin of S" = 1/2.	Cadmium	110-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-68
21121690-4	2011	At T = 5 K, the powder samples of the diamagnetically diluted Co(II)/Zn(II) and Co(II)/Cd(II) systems [Co/(Zn,Cd)   0.01] show intense electron paramagnetic resonance spectra, which were analyzed with an effective spin of S" = 1/2.	Cadmium	110-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-86
21121690-4	2011	At T = 5 K, the powder samples of the diamagnetically diluted Co(II)/Zn(II) and Co(II)/Cd(II) systems [Co/(Zn,Cd)   0.01] show intense electron paramagnetic resonance spectra, which were analyzed with an effective spin of S" = 1/2.	Sulfur	222-223	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-68
21121690-4	2011	At T = 5 K, the powder samples of the diamagnetically diluted Co(II)/Zn(II) and Co(II)/Cd(II) systems [Co/(Zn,Cd)   0.01] show intense electron paramagnetic resonance spectra, which were analyzed with an effective spin of S" = 1/2.	Sulfur	222-223	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-86
21528644-3	2011	The conversion of the primary amide to secondary or tertiary derivatives lowered the potency but favored the COX-2 selectivity thus yielding the compounds with stronger COX-2 inhibiting activity.	Amides	30-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-114
21528644-3	2011	The conversion of the primary amide to secondary or tertiary derivatives lowered the potency but favored the COX-2 selectivity thus yielding the compounds with stronger COX-2 inhibiting activity.	Amides	30-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	169-174
20868723-2	2011	Prostaglandin H synthases or cyclooxygenases (COX -1 and COX-2) play a central role in the inflammatory cascade by converting arachidonic acid into bioactive prostanoids.	Arachidonic Acid	126-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-62
21719995-6	2011	Among other gene expression changes in hippocampus, a role of cyclooxygenase (COX)-2, an inducible type of the rate-limiting enzyme of prostanoid synthesis, is focused.	Prostaglandins	135-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-84
22125393-0	2011	Virtual screening of 2,3-disubstituted-4(3H)-quinazolinones possessing benzenesulfonamide moiety for COX-2 inhibitor.	2,3-disubstituted-4(3h)-quinazolinones	21-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-106
22125393-0	2011	Virtual screening of 2,3-disubstituted-4(3H)-quinazolinones possessing benzenesulfonamide moiety for COX-2 inhibitor.	benzenesulfonamide	71-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-106
22125393-8	2011	We report the screening of various 2,3-disubstituted-4(3H)-quinazolinones possessing benzenesulfonamide moiety, directly or indirectly bound to the ring system, using the Protein-Ligand ANT System (PLANTS) docking software against the COX-2 enzyme.	2,3-disubstituted-4(3h)-quinazolinones	35-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	235-240
22125393-8	2011	We report the screening of various 2,3-disubstituted-4(3H)-quinazolinones possessing benzenesulfonamide moiety, directly or indirectly bound to the ring system, using the Protein-Ligand ANT System (PLANTS) docking software against the COX-2 enzyme.	benzenesulfonamide	85-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	235-240
22125393-9	2011	Various molecular structures of ligands were docked and scored to identify structurally similar ligands to SC-558 (reference ligand) in binding interaction to COX-2 binding site.	SC 558	107-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	159-164
21187340-3	2011	Resveratrol also causes nuclear accumulation of the enzyme cyclooxygenase (COX)-2 and of the oncogene suppressor protein, p53.	Resveratrol	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-81
21187340-6	2011	This finding implicates nuclear COX-2 in p53-mediated apoptosis induced by resveratrol.	Resveratrol	75-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-37
21187340-7	2011	Sumoylation is important to stabilization of p53 and a COX-2-SUMO-1 interaction suggests sumoylation of COX-2 in resveratrol-treated cells and (iv) chromatin immunoprecipitation studies showed binding of induced nuclear COX-2 to the promoter region of PIG3 and Bax, pro-apoptotic gene targets of transcriptionally active p53.	Resveratrol	113-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-60
21187340-7	2011	Sumoylation is important to stabilization of p53 and a COX-2-SUMO-1 interaction suggests sumoylation of COX-2 in resveratrol-treated cells and (iv) chromatin immunoprecipitation studies showed binding of induced nuclear COX-2 to the promoter region of PIG3 and Bax, pro-apoptotic gene targets of transcriptionally active p53.	Resveratrol	113-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
21187340-7	2011	Sumoylation is important to stabilization of p53 and a COX-2-SUMO-1 interaction suggests sumoylation of COX-2 in resveratrol-treated cells and (iv) chromatin immunoprecipitation studies showed binding of induced nuclear COX-2 to the promoter region of PIG3 and Bax, pro-apoptotic gene targets of transcriptionally active p53.	Resveratrol	113-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
21187340-8	2011	Nuclear accumulation of activated ERK1/2 and sumolyated COX-2 are essential to resveratrol-induced pSer-15-p53-mediated apoptosis in human ovarian cancer cells.	Resveratrol	79-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-61
20880055-3	2011	OBJECTIVES: Primarily, to assess whether treatment with the COX-2 selective inhibitor celecoxib inhibited biosynthesis of PGD(2) , monitored as urinary excretion of its major tetranor metabolite (PGDM).	Celecoxib	86-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-65
20880055-3	2011	OBJECTIVES: Primarily, to assess whether treatment with the COX-2 selective inhibitor celecoxib inhibited biosynthesis of PGD(2) , monitored as urinary excretion of its major tetranor metabolite (PGDM).	Prostaglandin D2	122-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-65
20880055-14	2011	By contrast, COX-2 contributes substantially to the biosynthesis of PGE(2) .	Prostaglandins E	68-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
20880055-15	2011	The asymmetric impact of celecoxib on prostanoid formation raises the possibility of long-term adverse consequences of COX-2 inhibition on airway homeostasis by the decreased formation of bronchodilator PGs and maintained production of increased levels of bronchoconstrictor PGs in asthmatics.	Phosphatidylglycerols	203-206	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-124
20880055-15	2011	The asymmetric impact of celecoxib on prostanoid formation raises the possibility of long-term adverse consequences of COX-2 inhibition on airway homeostasis by the decreased formation of bronchodilator PGs and maintained production of increased levels of bronchoconstrictor PGs in asthmatics.	Phosphatidylglycerols	275-278	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-124
21517752-5	2011	Cyclooxygenase (COX)-2 metabolizes the first enzymatic step in the conversion of arachidonic acid into prostanoids.	Arachidonic Acid	81-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-22
21517752-5	2011	Cyclooxygenase (COX)-2 metabolizes the first enzymatic step in the conversion of arachidonic acid into prostanoids.	Prostaglandins	103-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-22
21517752-6	2011	In particular, prostaglandin (PG)E2 generated at sites of inflammation and/or immune response is mainly COX-2-derived and has pro-inflammatory and immune regulatory activities.	Dinoprostone	15-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
21517752-7	2011	Pharmacological blockade of COX-2 in animal models of cancer translates into down-regulation of IDO1 expression at tumor sites and decreased levels of kynurenine in the circulation, underpinning the view that IDO1 might be downstream of COX-2.	Kynurenine	151-161	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
21546775-1	2011	BACKGROUND: The Cox-2 inhibitor, celecoxib (Pfizer Inc., N.Y., USA), is a promising chemopreventive agent [Arber et al.	Celecoxib	33-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-21
21625419-5	2011	Human brain microvascular endothelial cells were treated with a combination of phorbol 12-myristate 13-acetate (PMA), a carcinogen documented to increase MMP-9 and COX-2 through NF-kappaB, and several naturally occurring flavonoids.	Tetradecanoylphorbol Acetate	112-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	164-169
22038216-1	2011	The aim of this study was to evaluate the expression of COX-2 and Bcl-2 in primary fallopian tube carcinoma (PFTC), as well as their correlations with clinicopathologic features.	pftc	109-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-61
22038216-12	2011	We conclude that COX-2 and Bcl-2 may potentially be useful prognostic markers for PFTC.	pftc	82-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22
21067863-5	2011	Interestingly, the pro-apoptotic effects of combined niflumic acid-ciglitazone treatment were realized through Cox-2- and PPARgamma-independent mechanisms.	ciglitazone	67-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	111-116
21505570-9	2011	All the NSAIDs that inhibit COX2 can influence the cannabinoid system because a possible important degradative pathway for anandamide and 2-arachidonoyl glycerol might involve COX 2.	Cannabinoids	51-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-32
22114493-1	2011	BACKGROUND: Celecoxib, a cyclo-oxygenase (COX)-2 inhibitor, has been reported to mediate growth inhibitory effects and to induce apoptosis in various cancer cell lines.	Celecoxib	12-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-48
21804717-2	2011	Nowadays drugs like COX2 inhibitors and calcium channel modulators (Pregabalin and Gabapentin) are been increasingly used for postoperative pain management effectively.	Gabapentin	83-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-24
22289529-2	2011	This study determined whether the effect of genistein is mediated via suppression of cyclo-oxygenase (COX)-2 protein, and elucidated the mechanism of action of this effect  in the human gastric cancer cell line BGC-823.	Genistein	44-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-108
21131835-1	2011	The aim of the study was to assess the expression of cyclooxygenases (COX)-2 in nonepithelial ovarian malignancies.COX-2 immunohistochemical staining was performed on newly prepared deparaffinized slides from formalin-fixed, paraffin-embedded archival tissue blocks of unselected nonepithelial ovarian malignancies diagnosed between January 1993 and October 2009 after reconfirmation of the diagnosis.	Paraffin	184-192	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-120
21505570-9	2011	All the NSAIDs that inhibit COX2 can influence the cannabinoid system because a possible important degradative pathway for anandamide and 2-arachidonoyl glycerol might involve COX 2.	Cannabinoids	51-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	176-181
21505570-9	2011	All the NSAIDs that inhibit COX2 can influence the cannabinoid system because a possible important degradative pathway for anandamide and 2-arachidonoyl glycerol might involve COX 2.	anandamide	123-133	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-32
21505570-9	2011	All the NSAIDs that inhibit COX2 can influence the cannabinoid system because a possible important degradative pathway for anandamide and 2-arachidonoyl glycerol might involve COX 2.	anandamide	123-133	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	176-181
21505570-9	2011	All the NSAIDs that inhibit COX2 can influence the cannabinoid system because a possible important degradative pathway for anandamide and 2-arachidonoyl glycerol might involve COX 2.	glyceryl 2-arachidonate	138-161	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-32
21505570-9	2011	All the NSAIDs that inhibit COX2 can influence the cannabinoid system because a possible important degradative pathway for anandamide and 2-arachidonoyl glycerol might involve COX 2.	glyceryl 2-arachidonate	138-161	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	176-181
21209716-8	2011	The following anticancer mechanisms have been proposed: the inhibition of COX-2/PGE-2 pathway, the promotion of apoptosis, and the modulation of angiogenesis.	Dinoprostone	80-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
20382011-4	2011	We found that GPE attenuated TNFalpha-induced expression of inflammatory genes including interleukin (IL)-6, IL-1beta, IL-8, monocyte chemoattractant protein (MCP)-1, cyclooxygenase (COX)-2 and Toll-like receptor (TLR)-2.	gpe	14-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	167-189
22104269-1	2011	To investigate genes regulated by COX-2 or a COX-2 specific inhibitor, celecoxib, in irradiated cancer cells, we analyzed changes in gene expression using complementary DNA microarray following celecoxib or combined celecoxib and ionizing radiation (IR) treatment in a stable COX-2 knockdown A549 (AS) and a mock cell line (AN).	Celecoxib	71-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-50
22104269-1	2011	To investigate genes regulated by COX-2 or a COX-2 specific inhibitor, celecoxib, in irradiated cancer cells, we analyzed changes in gene expression using complementary DNA microarray following celecoxib or combined celecoxib and ionizing radiation (IR) treatment in a stable COX-2 knockdown A549 (AS) and a mock cell line (AN).	Celecoxib	71-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-50
22104269-1	2011	To investigate genes regulated by COX-2 or a COX-2 specific inhibitor, celecoxib, in irradiated cancer cells, we analyzed changes in gene expression using complementary DNA microarray following celecoxib or combined celecoxib and ionizing radiation (IR) treatment in a stable COX-2 knockdown A549 (AS) and a mock cell line (AN).	Celecoxib	194-203	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-39
22104269-1	2011	To investigate genes regulated by COX-2 or a COX-2 specific inhibitor, celecoxib, in irradiated cancer cells, we analyzed changes in gene expression using complementary DNA microarray following celecoxib or combined celecoxib and ionizing radiation (IR) treatment in a stable COX-2 knockdown A549 (AS) and a mock cell line (AN).	Celecoxib	194-203	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-39
22104269-5	2011	Among these, celecoxib regulated ras homolog gene family B and mitosin protein expression in a COX-2 dependent manner, especially in irradiated cells.	Celecoxib	13-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-100
22104269-8	2011	We also identified candidate molecules that may be responsible for COX-2-dependent radiosensitization by celecoxib.	Celecoxib	105-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-72
20821809-1	2011	INTRODUCTION: The cobalt is an essential element for leguminous plants but may be harmful for other species; for that reason determination of Co(II) is very important for the management of polluted areas and for discover plants with capacity for the hyperaccumulation of heavy metals, which has produced a growing necessity of fast, sensitive and selective analytical techniques.	Cobalt	18-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	142-148
21461558-0	2011	Tubeimoside-1 inhibits proliferation and induces apoptosis by increasing the Bax to Bcl-2 ratio and decreasing COX-2 expression in lung cancer A549 cells.	tubeimoside I	0-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	111-116
21461558-8	2011	Inhibition of COX-2 was also observed after treating the cells with TBMS1.	tubeimoside I	68-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
21220497-2	2011	This led to our interest in assessing the response of glioma cell lines to treatment with celecoxib, a selective COX-2 inhibitor.	Celecoxib	90-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-118
20821809-3	2011	METHODOLOGY: The sample was digested in a mixture of concentrated nitric acid and hydrogen peroxide, using an microwave oven to dissolve the Co(II).	Nitric Acid	66-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	141-147
20821809-3	2011	METHODOLOGY: The sample was digested in a mixture of concentrated nitric acid and hydrogen peroxide, using an microwave oven to dissolve the Co(II).	Hydrogen Peroxide	82-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	141-147
20821809-4	2011	The solution containing Co(II) ions was injected to an ionic chromatograph using oxalic acid as the eluent.	Oxalic Acid	81-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-30
20821809-5	2011	The detection was based on the catalytic effect of Co(II) on the luminol chemiluminescence using perborate or percarbonate as oxidants.	Luminol	65-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-57
20821809-5	2011	The detection was based on the catalytic effect of Co(II) on the luminol chemiluminescence using perborate or percarbonate as oxidants.	perborate	97-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-57
20821809-5	2011	The detection was based on the catalytic effect of Co(II) on the luminol chemiluminescence using perborate or percarbonate as oxidants.	sodium percarbonate	110-122	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-57
20821809-8	2011	The height and area showed linear dependences with the Co(II) concentration, which were used to quantify the heavy metal, with recoveries up to 95%.	Metals	115-120	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-61
21980345-0	2011	Targeting KSHV/HHV-8 latency with COX-2 selective inhibitor nimesulide: a potential chemotherapeutic modality for primary effusion lymphoma.	nimesulide	60-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-39
22039452-3	2011	Quercetin significantly attenuated intercellular adhesion molecule-1 (ICAM-1), interleukin (IL) -6, IL-8, and cyclooxygenase (COX) -2 mRNA expression, and inhibited IL-1beta-induced increases in ICAM-1, IL-6, and IL-8 mRNA.	Quercetin	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-133
22022384-0	2011	Green tea catechins reduce invasive potential of human melanoma cells by targeting COX-2, PGE2 receptors and epithelial-to-mesenchymal transition.	Catechin	10-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
22022418-8	2011	P-selectin glycoprotein ligand-1 (PSGL-1) blocking antibody, which abrogates MPA formation, abolished these effects, as did the cyclooxygenase (COX)-2 selective inhibitor NS-398, aspirin and the EP1/EP2-selective antagonist AH6809.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	171-177	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	128-150
22022384-4	2011	Treatment of A375 and Hs294t cells with EGCG resulted in a dose-dependent inhibition of cell migration or invasion of these cells, which was associated with a reduction in the levels of cyclooxygenase (COX)-2, prostaglandin (PG) E(2) and PGE(2) receptors (EP2 and EP4).	epigallocatechin gallate	40-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	186-208
22022418-8	2011	P-selectin glycoprotein ligand-1 (PSGL-1) blocking antibody, which abrogates MPA formation, abolished these effects, as did the cyclooxygenase (COX)-2 selective inhibitor NS-398, aspirin and the EP1/EP2-selective antagonist AH6809.	Aspirin	179-186	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	128-150
22022384-5	2011	Treatment of cells with celecoxib, a COX-2 inhibitor, also inhibited melanoma cell migration.	Celecoxib	24-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-42
22022384-6	2011	EGCG inhibits 12-O-tetradecanoylphorbol-13-acetate-, an inducer of COX-2, and PGE(2)-induced cell migration of cells.	epigallocatechin gallate	0-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-72
22022384-6	2011	EGCG inhibits 12-O-tetradecanoylphorbol-13-acetate-, an inducer of COX-2, and PGE(2)-induced cell migration of cells.	Tetradecanoylphorbol Acetate	14-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-72
22022384-8	2011	Moreover, EGCG inhibited the activation of NF-kappaB/p65, an upstream regulator of COX-2, in A375 melanoma cells, and treatment of cells with caffeic acid phenethyl ester, an inhibitor of NF-kappaB, also inhibited cell migration.	epigallocatechin gallate	10-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
22022384-10	2011	Together, these results indicate that EGCG, a major green tea catechin, has the ability to inhibit melanoma cell invasion/migration, an essential step of metastasis, by targeting the endogenous expression of COX-2, PGE(2) receptors and epithelial-to-mesenchymal transition.	epigallocatechin gallate	38-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	208-213
21738696-5	2011	Treatment of cells with 12-O-tetradecanoylphorbol-13-acetate, an inducer of COX-2, enhanced the phosphorylation of ERK1/2, a protein of mitogen-activated protein kinase family, and subsequently cell migration whereas both GSPs and celecoxib significantly inhibited 12-O-tetradecanoylphorbol-13-acetate-promoted cell migration as well as phosphorylation of ERK1/2.	Tetradecanoylphorbol Acetate	24-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-81
21738696-5	2011	Treatment of cells with 12-O-tetradecanoylphorbol-13-acetate, an inducer of COX-2, enhanced the phosphorylation of ERK1/2, a protein of mitogen-activated protein kinase family, and subsequently cell migration whereas both GSPs and celecoxib significantly inhibited 12-O-tetradecanoylphorbol-13-acetate-promoted cell migration as well as phosphorylation of ERK1/2.	Celecoxib	231-240	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-81
21738696-5	2011	Treatment of cells with 12-O-tetradecanoylphorbol-13-acetate, an inducer of COX-2, enhanced the phosphorylation of ERK1/2, a protein of mitogen-activated protein kinase family, and subsequently cell migration whereas both GSPs and celecoxib significantly inhibited 12-O-tetradecanoylphorbol-13-acetate-promoted cell migration as well as phosphorylation of ERK1/2.	Tetradecanoylphorbol Acetate	265-301	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-81
21738696-7	2011	Further, GSPs inhibited the activation of NF-kappaB/p65, an upstream regulator of COX-2, in melanoma cells, and treatment of cells with caffeic acid phenethyl ester, an inhibitor of NF-kappaB, also inhibited cell migration.	caffeic acid phenethyl ester	136-164	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
21779349-3	2011	METHODS AND FINDINGS: Three COX-2 polymorphisms, including -1195G&gt;A (rs689466), -765G&gt;C (rs20417), and 587Gly&gt;Arg (rs3218625), were genotyped in 357 GCA patients and 985 controls.	Arginine	119-122	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
21779360-0	2011	Hydrogen sulfide protects against chemical hypoxia-induced cytotoxicity and inflammation in HaCaT cells through inhibition of ROS/NF-kappaB/COX-2 pathway.	Hydrogen Sulfide	0-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-145
21779360-5	2011	In addition, pretreatment with NaHS markedly reduced CoCl(2)-induced COX-2 overexpression and PGE(2) secretion as well as intranuclear NF-kappaB p65 subunit accumulation (the central step of NF-kappaB activation).	sodium bisulfide	31-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-74
21779360-5	2011	In addition, pretreatment with NaHS markedly reduced CoCl(2)-induced COX-2 overexpression and PGE(2) secretion as well as intranuclear NF-kappaB p65 subunit accumulation (the central step of NF-kappaB activation).	cobaltous chloride	53-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-74
21779360-6	2011	Similar to the protective effect of H(2)S, both NS-398 (a selective COX-2 inhibitor) and PDTC (a selective NF-kappaB inhibitor) depressed not only CoCl(2)-induced cytotoxicity, but also the secretions of IL-1beta, IL-6 and IL-8.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	48-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-73
21779360-6	2011	Similar to the protective effect of H(2)S, both NS-398 (a selective COX-2 inhibitor) and PDTC (a selective NF-kappaB inhibitor) depressed not only CoCl(2)-induced cytotoxicity, but also the secretions of IL-1beta, IL-6 and IL-8.	cobaltous chloride	147-154	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-73
21779360-7	2011	Importantly, PDTC obviously attenuated overexpression of COX-2 induced by CoCl(2).	cobaltous chloride	74-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-62
21779360-9	2011	Taken together, the findings of the present study have demonstrated for the first time that H(2)S protects HaCaT cells against CoCl(2)-induced injuries and inflammatory responses through inhibition of ROS-activated NF-kappaB/COX-2 pathway.	Hydrogen Sulfide	92-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	225-230
21042646-3	2010	[Cd(3)(UO(2))(6)(PO(3)CH(2)CO(2))(6)(H(2)O)(13)] 6H(2)O forms a rhombohedral channel structure with hydrated Cd(ii) within the channels.	co(2))	27-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-114
21779360-9	2011	Taken together, the findings of the present study have demonstrated for the first time that H(2)S protects HaCaT cells against CoCl(2)-induced injuries and inflammatory responses through inhibition of ROS-activated NF-kappaB/COX-2 pathway.	cobaltous chloride	127-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	225-230
21779360-9	2011	Taken together, the findings of the present study have demonstrated for the first time that H(2)S protects HaCaT cells against CoCl(2)-induced injuries and inflammatory responses through inhibition of ROS-activated NF-kappaB/COX-2 pathway.	ros	201-204	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	225-230
21542252-5	2011	ATL (AT mean aspirin triggered therefore "depend on aspirin") synthesis, via COX-2, reduces the severity of damage gastrointestinal tract induced by NSAIDs.	Aspirin	13-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-82
21542252-5	2011	ATL (AT mean aspirin triggered therefore "depend on aspirin") synthesis, via COX-2, reduces the severity of damage gastrointestinal tract induced by NSAIDs.	Aspirin	52-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-82
21417548-7	2011	PAF induced expression of group IIA, IID and IVA PLA2, and COX2.	Platelet Activating Factor	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-63
21203429-10	2010	CONCLUSIONS/SIGNIFICANCE: Our data suggests that upon ligand activation, CysLT(1)R is tyrosine-phosphorylated and released from heterodimers with CysLT(2)R and, subsequently, internalizes from the plasma membrane to the nuclear membrane in a clathrin-, arrestin-3-, and Rab-5-dependent manner, thus, enabling Erk1/2 signaling and downstream transcription of the COX-2 gene.	Tyrosine	86-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	362-367
21042646-3	2010	[Cd(3)(UO(2))(6)(PO(3)CH(2)CO(2))(6)(H(2)O)(13)] 6H(2)O forms a rhombohedral channel structure with hydrated Cd(ii) within the channels.	6H	49-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-114
21060954-1	2010	Two unique six-connected self-penetrating coordination polymers with a new (4(4).6(10).8) network topology, derived from the cross-linking of two 6(6)-dia subnets, were constructed from Ni(II) or Co(II) and two types of V-shaped tectons.	Polymers	55-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	196-202
21522530-1	2010	In polymeric title compound, {[Co(2)(C(7)H(2)N(2)O(7))(2)(H(2)O)(6)] 2H(2)O}(n), obtained from the reaction of 3,5-dinitro-salicylic acid with cobalt(II) acetate, both Co(II) atoms are located on inversion centres and exhibit a distorted octahedral coordination geometry.	co(2)	31-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	168-174
21522530-1	2010	In polymeric title compound, {[Co(2)(C(7)H(2)N(2)O(7))(2)(H(2)O)(6)] 2H(2)O}(n), obtained from the reaction of 3,5-dinitro-salicylic acid with cobalt(II) acetate, both Co(II) atoms are located on inversion centres and exhibit a distorted octahedral coordination geometry.	3,5-dinitrosalicylic acid	111-137	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	168-174
21082809-2	2010	d-(-)-quinic acid is a cellular alpha-hydroxycarboxylate metal ion binder, which reacts with Co(II) and Zn(II) under pH-specific hydrothermal conditions, leading to the isolation of two new species [Co(2)(C(7)H(11)O(6))(4)](n) nH(2)O (1) and [Zn(3)(C(7)H(11)O(6))(6)](n) nH(2)O (2).	Quinic Acid	0-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-99
21082809-2	2010	d-(-)-quinic acid is a cellular alpha-hydroxycarboxylate metal ion binder, which reacts with Co(II) and Zn(II) under pH-specific hydrothermal conditions, leading to the isolation of two new species [Co(2)(C(7)H(11)O(6))(4)](n) nH(2)O (1) and [Zn(3)(C(7)H(11)O(6))(6)](n) nH(2)O (2).	alpha-hydroxycarboxylate	32-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-99
21082809-2	2010	d-(-)-quinic acid is a cellular alpha-hydroxycarboxylate metal ion binder, which reacts with Co(II) and Zn(II) under pH-specific hydrothermal conditions, leading to the isolation of two new species [Co(2)(C(7)H(11)O(6))(4)](n) nH(2)O (1) and [Zn(3)(C(7)H(11)O(6))(6)](n) nH(2)O (2).	Metals	57-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-99
21082809-2	2010	d-(-)-quinic acid is a cellular alpha-hydroxycarboxylate metal ion binder, which reacts with Co(II) and Zn(II) under pH-specific hydrothermal conditions, leading to the isolation of two new species [Co(2)(C(7)H(11)O(6))(4)](n) nH(2)O (1) and [Zn(3)(C(7)H(11)O(6))(6)](n) nH(2)O (2).	co(2)	199-204	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-99
21082809-6	2010	The magnetic susceptibility and solid-state/frozen solution EPR data on 1 support the presence of a high-spin octahedral Co(II) in an oxygen environment, having a ground state with an effective spin of S = 1/2.	Oxygen	134-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-127
21162728-10	2010	A CYP1A1 inhibitor (alpha-naphthoflavone), nearly abolished the DEP-induced expression of IL-8 and COX-2.	alpha-naphthoflavone	20-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-104
21162728-12	2010	A p38 inhibitor (SB202190) strongly reduced DEP-induced expression of IL-6, IL-8 and COX-2, but only moderately affected the expression of CYP1A1.	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	17-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-90
20976340-1	2010	Two new azido-Co(II) complexes with pyrazine carboxylato ligands, [Co(N(3))(L) H(2)O](n) (L = pyrazine-2-carboxylato) (1) and [CoNa(N(3))(2)(L)](n) (2), have been obtained by carefully tuning the Co(II):N(3)(-) ratio.	Pyrazines	36-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-20
20810212-0	2010	Preparation and characterization of chelating fibers based on natural wool for removal of Hg(II), Cu(II) and Co(II) metal ions from aqueous solutions.	Metals	116-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-115
20976340-1	2010	Two new azido-Co(II) complexes with pyrazine carboxylato ligands, [Co(N(3))(L) H(2)O](n) (L = pyrazine-2-carboxylato) (1) and [CoNa(N(3))(2)(L)](n) (2), have been obtained by carefully tuning the Co(II):N(3)(-) ratio.	co(n(3)	67-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-20
20976340-1	2010	Two new azido-Co(II) complexes with pyrazine carboxylato ligands, [Co(N(3))(L) H(2)O](n) (L = pyrazine-2-carboxylato) (1) and [CoNa(N(3))(2)(L)](n) (2), have been obtained by carefully tuning the Co(II):N(3)(-) ratio.	co(n(3)	67-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
20976340-1	2010	Two new azido-Co(II) complexes with pyrazine carboxylato ligands, [Co(N(3))(L) H(2)O](n) (L = pyrazine-2-carboxylato) (1) and [CoNa(N(3))(2)(L)](n) (2), have been obtained by carefully tuning the Co(II):N(3)(-) ratio.	Water	79-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-20
20976340-1	2010	Two new azido-Co(II) complexes with pyrazine carboxylato ligands, [Co(N(3))(L) H(2)O](n) (L = pyrazine-2-carboxylato) (1) and [CoNa(N(3))(2)(L)](n) (2), have been obtained by carefully tuning the Co(II):N(3)(-) ratio.	Water	79-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
20976340-1	2010	Two new azido-Co(II) complexes with pyrazine carboxylato ligands, [Co(N(3))(L) H(2)O](n) (L = pyrazine-2-carboxylato) (1) and [CoNa(N(3))(2)(L)](n) (2), have been obtained by carefully tuning the Co(II):N(3)(-) ratio.	Pyrazines	94-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-20
20976340-1	2010	Two new azido-Co(II) complexes with pyrazine carboxylato ligands, [Co(N(3))(L) H(2)O](n) (L = pyrazine-2-carboxylato) (1) and [CoNa(N(3))(2)(L)](n) (2), have been obtained by carefully tuning the Co(II):N(3)(-) ratio.	2-carboxylato)	103-117	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-20
20883674-1	2010	Celecoxib is a selective cyclooxygenase (COX)-2 inhibitor used to treat inflammation, while selenium is known to down-regulate the transcription of COX-2 and other pro-inflammatory genes.	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-47
20945441-1	2010	A high-spin Co(II) cluster with a rare pentagonal molecular structure and formula [Co(5)(CO(3))(2)(bpp)(5)]ClO(4) (1; Hbpp is 2,6-bis(phenyliminomethyl)-4-methylphenolate) has been synthesized and characterized by single-crystal X-ray diffraction.	co(5)(co(3))(2)(bpp)(5)]clo	83-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-18
20945441-1	2010	A high-spin Co(II) cluster with a rare pentagonal molecular structure and formula [Co(5)(CO(3))(2)(bpp)(5)]ClO(4) (1; Hbpp is 2,6-bis(phenyliminomethyl)-4-methylphenolate) has been synthesized and characterized by single-crystal X-ray diffraction.	2,6-bis(phenyliminomethyl)-4-methylphenolate	126-170	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-18
20945441-3	2010	The irregular coordination of the carbonate ions to the metal centers results in a combination of coordination numbers (CNs) of the Co(II) ions of five and six.	Carbonates	34-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-138
20945441-3	2010	The irregular coordination of the carbonate ions to the metal centers results in a combination of coordination numbers (CNs) of the Co(II) ions of five and six.	Metals	56-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-138
20883674-1	2010	Celecoxib is a selective cyclooxygenase (COX)-2 inhibitor used to treat inflammation, while selenium is known to down-regulate the transcription of COX-2 and other pro-inflammatory genes.	Selenium	92-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	148-153
20883674-7	2010	While these studies suggest that selenocoxib-2, but not celecoxib and selenocoxib-3, targets upstream events in the NF-kappaB signaling axis, the ability to effectively suppress NF-kappaB activation independent of cellular selenoprotein synthesis opens possibilities for a new generation of COX-2 inhibitors with significant and broader anti-inflammatory potential.	selenocoxib-2	33-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	291-296
21067147-1	2010	New Co(II) members of the family of multifunctional materials of general formula [DAMS](4)[M(2)Co(C(2)O(4))(6)] 2DAMBA 2H(2)O (M(III) = Rh, Fe, Cr; DAMBA = para-dimethylaminobenzaldehyde and [DAMS(+)] = trans-4-(4-dimethylaminostyryl)-1-methylpyridinium) have been isolated and characterized.	co(c	95-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
20963488-8	2010	Bufalin induced the apoptosis and cell cycle arrest by affecting the protein expressions of Bcl-2/Bax, cytochrome c, caspase-3, PARP, p53, p21WAF1, cyclinD1, and COX-2 in A549 cells.	bufalin	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	162-167
21067147-1	2010	New Co(II) members of the family of multifunctional materials of general formula [DAMS](4)[M(2)Co(C(2)O(4))(6)] 2DAMBA 2H(2)O (M(III) = Rh, Fe, Cr; DAMBA = para-dimethylaminobenzaldehyde and [DAMS(+)] = trans-4-(4-dimethylaminostyryl)-1-methylpyridinium) have been isolated and characterized.	2damba 2h	112-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
21067147-1	2010	New Co(II) members of the family of multifunctional materials of general formula [DAMS](4)[M(2)Co(C(2)O(4))(6)] 2DAMBA 2H(2)O (M(III) = Rh, Fe, Cr; DAMBA = para-dimethylaminobenzaldehyde and [DAMS(+)] = trans-4-(4-dimethylaminostyryl)-1-methylpyridinium) have been isolated and characterized.	Rhodium	136-138	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
21067147-1	2010	New Co(II) members of the family of multifunctional materials of general formula [DAMS](4)[M(2)Co(C(2)O(4))(6)] 2DAMBA 2H(2)O (M(III) = Rh, Fe, Cr; DAMBA = para-dimethylaminobenzaldehyde and [DAMS(+)] = trans-4-(4-dimethylaminostyryl)-1-methylpyridinium) have been isolated and characterized.	Iron	140-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
21067147-1	2010	New Co(II) members of the family of multifunctional materials of general formula [DAMS](4)[M(2)Co(C(2)O(4))(6)] 2DAMBA 2H(2)O (M(III) = Rh, Fe, Cr; DAMBA = para-dimethylaminobenzaldehyde and [DAMS(+)] = trans-4-(4-dimethylaminostyryl)-1-methylpyridinium) have been isolated and characterized.	Chromium	144-146	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
21067147-1	2010	New Co(II) members of the family of multifunctional materials of general formula [DAMS](4)[M(2)Co(C(2)O(4))(6)] 2DAMBA 2H(2)O (M(III) = Rh, Fe, Cr; DAMBA = para-dimethylaminobenzaldehyde and [DAMS(+)] = trans-4-(4-dimethylaminostyryl)-1-methylpyridinium) have been isolated and characterized.	p-dimethylaminobenzaldehyde	156-186	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
21067147-1	2010	New Co(II) members of the family of multifunctional materials of general formula [DAMS](4)[M(2)Co(C(2)O(4))(6)] 2DAMBA 2H(2)O (M(III) = Rh, Fe, Cr; DAMBA = para-dimethylaminobenzaldehyde and [DAMS(+)] = trans-4-(4-dimethylaminostyryl)-1-methylpyridinium) have been isolated and characterized.	trans-4-(4-dimethylaminostyryl)-1-methylpyridinium	203-253	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
21067147-5	2010	The Cr(III) derivative is characterized by ferromagnetic Cr(III)-Co(II) interactions.	tris(1,10-phenanthroline)chromium(III) chloride	4-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-71
21067147-5	2010	The Cr(III) derivative is characterized by ferromagnetic Cr(III)-Co(II) interactions.	tris(1,10-phenanthroline)chromium(III) chloride	57-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-71
21067147-6	2010	Most relevantly, the Fe(III) compound is characterized by a moderate antiferromagnetic interaction between Fe(III) and Co(II), resulting in a ferrimagnetic like structure.	ferric sulfate	21-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-125
21067147-6	2010	Most relevantly, the Fe(III) compound is characterized by a moderate antiferromagnetic interaction between Fe(III) and Co(II), resulting in a ferrimagnetic like structure.	ferric sulfate	107-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-125
20865247-2	2010	Using quantitative RT-PCR as the initial screening assay, we identified antagonistic actions of zerumbone and auraptene against the action of TCDD and DDT in up-regulating the mRNA expressions of COX-2 and VEGF.	zerumbone	96-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	196-201
20865247-2	2010	Using quantitative RT-PCR as the initial screening assay, we identified antagonistic actions of zerumbone and auraptene against the action of TCDD and DDT in up-regulating the mRNA expressions of COX-2 and VEGF.	aurapten	110-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	196-201
20865247-2	2010	Using quantitative RT-PCR as the initial screening assay, we identified antagonistic actions of zerumbone and auraptene against the action of TCDD and DDT in up-regulating the mRNA expressions of COX-2 and VEGF.	Polychlorinated Dibenzodioxins	142-146	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	196-201
20865247-2	2010	Using quantitative RT-PCR as the initial screening assay, we identified antagonistic actions of zerumbone and auraptene against the action of TCDD and DDT in up-regulating the mRNA expressions of COX-2 and VEGF.	DDT	151-154	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	196-201
20667716-3	2010	At 800 degrees C, the impregnation of Fe (III), Ni (II), Co (II) or Ru (IV) led to almost complete conversion of the solid biomass into gas/liquid products, producing an extremely low char yield (&lt;1-4 wt.%), and a very high yield of combustible gas (from 51.7 wt.% for Fe to 84 wt.% for Ru).	Iron	38-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-70
20846162-4	2010	Proinflammatory cytokines mainly increased indoleamine-2,3-dioxygenase expression, whereas ASC cultured with MLR showed increased expression of COX-2, involved in prostaglandin E(2) production.	Dinoprostone	163-181	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	144-149
20593240-0	2010	Selective COX-2 inhibition affects fatty acids, but not COX mRNA expression in patients with FAP.	Fatty Acids	35-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
20974503-0	2010	Synthesis and biological evaluation of N-substituted-3,5-diphenyl-2-pyrazoline derivatives as cyclooxygenase (COX-2) inhibitors.	n-substituted-3,5-diphenyl-2-pyrazoline	39-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-115
20974503-1	2010	Eighteen new 1-N-substituted-3,5-diphenyl-2-pyrazoline derivatives have been synthesized and cyclooxygenase (COX-1 and COX-2) inhibitory activities have been evaluated.	1-n-substituted-3,5-diphenyl-2-pyrazoline	13-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-124
20826149-0	2010	Butein downregulates phorbol 12-myristate 13-acetate-induced COX-2 transcriptional activity in cancerous and non-cancerous breast cells.	butein	0-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-66
20826149-0	2010	Butein downregulates phorbol 12-myristate 13-acetate-induced COX-2 transcriptional activity in cancerous and non-cancerous breast cells.	Tetradecanoylphorbol Acetate	21-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-66
20826149-4	2010	This study examined the potential suppressive effect of the flavonoid on phorbol 12-myristate 13-acetate (PMA)-induced COX-2 expression in the non-tumorigenic MCF-10A and cancerous MCF-7 breast cells.	Flavonoids	60-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-124
20826149-4	2010	This study examined the potential suppressive effect of the flavonoid on phorbol 12-myristate 13-acetate (PMA)-induced COX-2 expression in the non-tumorigenic MCF-10A and cancerous MCF-7 breast cells.	Tetradecanoylphorbol Acetate	73-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-124
20826149-4	2010	This study examined the potential suppressive effect of the flavonoid on phorbol 12-myristate 13-acetate (PMA)-induced COX-2 expression in the non-tumorigenic MCF-10A and cancerous MCF-7 breast cells.	Tetradecanoylphorbol Acetate	106-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-124
20826149-10	2010	This study showed that butein down-regulated PMA-induced COX-2 expression in both cancerous and non-cancerous breast cells, and such findings could provide the basis for pharmaceutical development of butein.	butein	23-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-62
20826149-10	2010	This study showed that butein down-regulated PMA-induced COX-2 expression in both cancerous and non-cancerous breast cells, and such findings could provide the basis for pharmaceutical development of butein.	Tetradecanoylphorbol Acetate	45-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-62
20826149-10	2010	This study showed that butein down-regulated PMA-induced COX-2 expression in both cancerous and non-cancerous breast cells, and such findings could provide the basis for pharmaceutical development of butein.	butein	200-206	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-62
20593240-3	2010	Although this selective COX-2 inhibitor, like diet, may alter the fatty acid and eicosanoid pattern, data on the potential alteration in tissues after use, are scarce.	Fatty Acids	66-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
20593240-3	2010	Although this selective COX-2 inhibitor, like diet, may alter the fatty acid and eicosanoid pattern, data on the potential alteration in tissues after use, are scarce.	Eicosanoids	81-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
24825998-1	2010	Rofecoxib is a selective cyclooxygenase COX-2 enzyme inhibitor with chemoprotective effect against cancer in experimental models.	rofecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
21067158-3	2010	Co(III)H is subsequently reduced by excess Co(I)-diglyoxime in solution to produce Co(II)H (k(red) = 9.2 x 10(6) M(-1) s(-1)), which is then protonated to yield Co(II)-diglyoxime and H(2).	co(iii)h	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
21067158-3	2010	Co(III)H is subsequently reduced by excess Co(I)-diglyoxime in solution to produce Co(II)H (k(red) = 9.2 x 10(6) M(-1) s(-1)), which is then protonated to yield Co(II)-diglyoxime and H(2).	co(i)-diglyoxime	43-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
21067158-3	2010	Co(III)H is subsequently reduced by excess Co(I)-diglyoxime in solution to produce Co(II)H (k(red) = 9.2 x 10(6) M(-1) s(-1)), which is then protonated to yield Co(II)-diglyoxime and H(2).	co(i)-diglyoxime	43-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
21067158-3	2010	Co(III)H is subsequently reduced by excess Co(I)-diglyoxime in solution to produce Co(II)H (k(red) = 9.2 x 10(6) M(-1) s(-1)), which is then protonated to yield Co(II)-diglyoxime and H(2).	diglyoxime	49-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
21067158-3	2010	Co(III)H is subsequently reduced by excess Co(I)-diglyoxime in solution to produce Co(II)H (k(red) = 9.2 x 10(6) M(-1) s(-1)), which is then protonated to yield Co(II)-diglyoxime and H(2).	diglyoxime	49-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
21067158-3	2010	Co(III)H is subsequently reduced by excess Co(I)-diglyoxime in solution to produce Co(II)H (k(red) = 9.2 x 10(6) M(-1) s(-1)), which is then protonated to yield Co(II)-diglyoxime and H(2).	h(2)	183-187	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
24825998-7	2010	It is concluded that rofecoxib offered protection against copper ions or UVB induced-DNA damage via different mechanisms not related to the inhibition COX-2.	rofecoxib	21-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-156
21067158-3	2010	Co(III)H is subsequently reduced by excess Co(I)-diglyoxime in solution to produce Co(II)H (k(red) = 9.2 x 10(6) M(-1) s(-1)), which is then protonated to yield Co(II)-diglyoxime and H(2).	h(2)	183-187	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
20924071-7	2010	These results suggest that FAK regulates the production of prostaglandin E(2) via the transcriptional regulation of COX-2 mRNA in compressive stimulated PDL cells.	Dinoprostone	59-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-121
20971925-2	2010	We hypothesized that Cox-2 is induced by TLR activation and is necessary for optimal AMP production, and that inhibitors of Cox-2 may therefore inhibit antimicrobial action.	Adenosine Monophosphate	85-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-26
20971925-3	2010	Normal human keratinocytes (NHEKs) stimulated with a TLR2/6 ligand, macrophage-activating lipopeptide-2, or a TLR3 ligand, polyinosinic-polycytidylic acid, increased Cox-2 mRNA and protein and increased PGE(2), a product of Cox-2.	Poly I-C	123-154	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	166-171
20971925-4	2010	Treatment with a Cox-2 selective inhibitor (SC-58125) or Cox-2 small interfering RNA attenuated hBD2 and hBD3 production in NHEKs when stimulated with macrophage-activating lipopeptide-2, polyinosinic-polycytidylic acid, or UVB (15 mJ/cm(2)), but it did not attenuate vitamin D3-induced cathelicidin.	1-((4-methylsulfonyl)phenyl)-3-trifluoromethyl-5-(4-fluorophenyl)pyrazole	44-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22
20971925-3	2010	Normal human keratinocytes (NHEKs) stimulated with a TLR2/6 ligand, macrophage-activating lipopeptide-2, or a TLR3 ligand, polyinosinic-polycytidylic acid, increased Cox-2 mRNA and protein and increased PGE(2), a product of Cox-2.	Poly I-C	123-154	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	224-229
20971925-4	2010	Treatment with a Cox-2 selective inhibitor (SC-58125) or Cox-2 small interfering RNA attenuated hBD2 and hBD3 production in NHEKs when stimulated with macrophage-activating lipopeptide-2, polyinosinic-polycytidylic acid, or UVB (15 mJ/cm(2)), but it did not attenuate vitamin D3-induced cathelicidin.	Poly I-C	188-219	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-62
20237816-1	2010	Stilbene analogs are a new class of anti-inflammatory compounds that effectively inhibit COX-2, which is the major target in the treatment of inflammation and pain.	Stilbenes	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-94
20971925-4	2010	Treatment with a Cox-2 selective inhibitor (SC-58125) or Cox-2 small interfering RNA attenuated hBD2 and hBD3 production in NHEKs when stimulated with macrophage-activating lipopeptide-2, polyinosinic-polycytidylic acid, or UVB (15 mJ/cm(2)), but it did not attenuate vitamin D3-induced cathelicidin.	Cholecalciferol	268-278	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-62
20858500-1	2010	Celecoxib is a COX-2 inhibitor that has been related to an increased cardiovascular risk and that exerts several actions on different targets.	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-20
20237816-3	2010	Our aim was to better understand the structural and chemical features responsible for the recognition mechanism of these compounds, and to explore their binding modes of interaction at the active site by comparing them with COX-2 co-crystallized with SC-558.	SC 558	251-257	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	224-229
20379791-2	2010	We hypothesized that activation of cytosolic phospholipase A2 (cPLA2) and cyclooxygenase (COX-2) by ethanol in astrocytes enhanced the secretion of inflammatory agents via the interactive tyrosine phosphorylation of toll-like receptor 4 (TLR4) and Src kinase.	Ethanol	100-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-95
20379791-2	2010	We hypothesized that activation of cytosolic phospholipase A2 (cPLA2) and cyclooxygenase (COX-2) by ethanol in astrocytes enhanced the secretion of inflammatory agents via the interactive tyrosine phosphorylation of toll-like receptor 4 (TLR4) and Src kinase.	Tyrosine	188-196	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-95
20379791-4	2010	Secretion of PGE2 was associated with induction of cPLA2 activity and protein content as well as COX-2 protein level in a Src phosphorylation-dependent manner that occurred by enhanced transcription.	Dinoprostone	13-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
20379791-5	2010	Immunoprecipitation and Western blot analyses indicated that the interactive tyrosine phosphorylation of TLR4-Src complex at the cell membrane triggered the activation of cPLA2 and COX-2 in the cytoplasm through a Src signaling intermediate.	Tyrosine	77-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	181-186
20379791-6	2010	Inhibition of ethanol metabolism, blockage of Src activity, or inactivation of TLR4 prevented the activation of cPLA2 and COX-2 as well as diminished PGE2 production, suggesting that interactive phosphorylation of TLR4-Src regulated the pro-inflammatory response in astrocytes.	Ethanol	14-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-127
20951077-0	2010	A role for COX2-derived PGE2 and PGE2-receptor subtypes in head and neck squamous carcinoma cell proliferation.	Dinoprostone	24-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-15
21071513-5	2010	Also contributing to D-DTs regulation of COX-2 expression are the activities of both c-jun-N-terminal kinase and the MIF-interacting protein, Jab1/CSN5.	DDT	21-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-46
20951077-2	2010	COX-2 promotes the release of the pro-inflammatory mediator prostaglandin E2 (PGE2), which acts on its cell surface G protein-coupled receptors EP1, EP2, EP3, and EP4.	Dinoprostone	60-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
20951077-2	2010	COX-2 promotes the release of the pro-inflammatory mediator prostaglandin E2 (PGE2), which acts on its cell surface G protein-coupled receptors EP1, EP2, EP3, and EP4.	Dinoprostone	78-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
20951077-5	2010	The ability of selective COX-2 inhibition to block PGE2 secretion was measured by ELISA specific assays.	Dinoprostone	51-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-30
20951077-8	2010	HNSCC cells secrete PGE2, which can be suppressed by low concentrations of COX-2 selective inhibitors, without inhibiting cell proliferation.	Dinoprostone	20-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
20951077-10	2010	Overall, our study supports the emerging notion that PGE2 produced in the tumor microenvironment by the overexpression of COX-2 in tumoral and inflammatory cells may promote the growth of HNSCC cells in an autocrine and paracrine fashion by acting on PGE2 receptors that are widely expressed in most HNSCC cancer cells.	Dinoprostone	53-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-127
20840853-5	2010	Concentration- and time-dependent increases in mRNA and protein expression of eicosanoid biosynthetic enzymes including COX-2, 5-lipoxygenase, microsomal PGE2 synthases, leukotriene (LT) A4 hydrolase and LTC4 synthase were observed in CEES-treated skin equivalents, as well as in antioxidant enzymes, glutathione S-transferases A1-2 (GSTA1-2), GSTA3 and GSTA4.	Eicosanoids	78-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-125
21214033-6	2010	At the optimum conditions, the copper extraction was approximately 90%, significantly greater than that of the other coexisting ions--nickel(II) [Ni(II)], cobalt(II) [Co(II)], and manganese(II) [Mn(II)].	Copper	31-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	167-173
21589310-1	2010	In the title one-dimensional coordination polymer, [Co(C(2)H(3)O(2))(2)(C(26)H(18)N(4))](n), the Co(II) atom (site symmetry 2) is coordinated by two O,O"-bidentate acetate ions and two 4,4"-bis-(benzimidazol-1-yl)biphenyl ligands in a distorted cis-CoN(2)O(4) octa-hedral geometry.	Polymers	42-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-103
21589310-1	2010	In the title one-dimensional coordination polymer, [Co(C(2)H(3)O(2))(2)(C(26)H(18)N(4))](n), the Co(II) atom (site symmetry 2) is coordinated by two O,O"-bidentate acetate ions and two 4,4"-bis-(benzimidazol-1-yl)biphenyl ligands in a distorted cis-CoN(2)O(4) octa-hedral geometry.	co(c(2)h(3)o(2))	52-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-103
21589310-1	2010	In the title one-dimensional coordination polymer, [Co(C(2)H(3)O(2))(2)(C(26)H(18)N(4))](n), the Co(II) atom (site symmetry 2) is coordinated by two O,O"-bidentate acetate ions and two 4,4"-bis-(benzimidazol-1-yl)biphenyl ligands in a distorted cis-CoN(2)O(4) octa-hedral geometry.	4,4"-bis-(benzimidazol-1-yl)biphenyl	185-221	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-103
21589310-1	2010	In the title one-dimensional coordination polymer, [Co(C(2)H(3)O(2))(2)(C(26)H(18)N(4))](n), the Co(II) atom (site symmetry 2) is coordinated by two O,O"-bidentate acetate ions and two 4,4"-bis-(benzimidazol-1-yl)biphenyl ligands in a distorted cis-CoN(2)O(4) octa-hedral geometry.	Folic Acid	81-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-103
21589310-1	2010	In the title one-dimensional coordination polymer, [Co(C(2)H(3)O(2))(2)(C(26)H(18)N(4))](n), the Co(II) atom (site symmetry 2) is coordinated by two O,O"-bidentate acetate ions and two 4,4"-bis-(benzimidazol-1-yl)biphenyl ligands in a distorted cis-CoN(2)O(4) octa-hedral geometry.	-con(2)o	248-256	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-103
21589310-1	2010	In the title one-dimensional coordination polymer, [Co(C(2)H(3)O(2))(2)(C(26)H(18)N(4))](n), the Co(II) atom (site symmetry 2) is coordinated by two O,O"-bidentate acetate ions and two 4,4"-bis-(benzimidazol-1-yl)biphenyl ligands in a distorted cis-CoN(2)O(4) octa-hedral geometry.	o,o"-bidentate acetate	149-171	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-103
21589310-1	2010	In the title one-dimensional coordination polymer, [Co(C(2)H(3)O(2))(2)(C(26)H(18)N(4))](n), the Co(II) atom (site symmetry 2) is coordinated by two O,O"-bidentate acetate ions and two 4,4"-bis-(benzimidazol-1-yl)biphenyl ligands in a distorted cis-CoN(2)O(4) octa-hedral geometry.	octa-hedral	260-271	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-103
20945308-1	2010	The Co(II)/Co(III)-induced decomposition of hydroperoxides is an important reaction in many industrial processes and is referred to as deperoxidation.	Hydrogen Peroxide	44-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
20945308-2	2010	In the first step of the so-called Haber-Weiss cycle, alkoxyl radicals and Co(III)-OH species are generated upon the reaction of the Co(II) ion with ROOH.	Lipid Peroxides	149-153	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
20945308-3	2010	The catalytic cycle is closed upon the regeneration of the Co(II) ion through the reaction of the Co(III)-OH species with a second ROOH molecule, thus producing one equivalent of the peroxyl radicals.	Lipid Peroxides	131-135	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
20945308-3	2010	The catalytic cycle is closed upon the regeneration of the Co(II) ion through the reaction of the Co(III)-OH species with a second ROOH molecule, thus producing one equivalent of the peroxyl radicals.	perhydroxyl radical	183-199	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
21589279-1	2010	In the title compound, [Co(2)(C(7)H(8)NO)(3)(N(3))(3)] CH(3)CN, the two Co(II) ions in the dinuclear complex have different coordination environments, both in a distorted octa-hedral geometry.	co(2)	24-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-78
21589279-1	2010	In the title compound, [Co(2)(C(7)H(8)NO)(3)(N(3))(3)] CH(3)CN, the two Co(II) ions in the dinuclear complex have different coordination environments, both in a distorted octa-hedral geometry.	c(7)h(8)no)	30-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-78
21589279-1	2010	In the title compound, [Co(2)(C(7)H(8)NO)(3)(N(3))(3)] CH(3)CN, the two Co(II) ions in the dinuclear complex have different coordination environments, both in a distorted octa-hedral geometry.	n(3))(3)	45-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-78
21589279-2	2010	One Co(II) atom is coordinated by three O atoms from the three 2-hy-droxy-ethyl-pyridine (HEP) bridging ligands, two N atoms from two HEP ligands and one azido ligand, while the other Co(II) atom is coordinated by the same three O atoms, one N atom from an HEP ligand and two azido ligands.	2-hy-droxy-ethyl-pyridine	63-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
21589279-2	2010	One Co(II) atom is coordinated by three O atoms from the three 2-hy-droxy-ethyl-pyridine (HEP) bridging ligands, two N atoms from two HEP ligands and one azido ligand, while the other Co(II) atom is coordinated by the same three O atoms, one N atom from an HEP ligand and two azido ligands.	epolamine	90-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
21589279-2	2010	One Co(II) atom is coordinated by three O atoms from the three 2-hy-droxy-ethyl-pyridine (HEP) bridging ligands, two N atoms from two HEP ligands and one azido ligand, while the other Co(II) atom is coordinated by the same three O atoms, one N atom from an HEP ligand and two azido ligands.	Nitrogen	117-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
21589279-2	2010	One Co(II) atom is coordinated by three O atoms from the three 2-hy-droxy-ethyl-pyridine (HEP) bridging ligands, two N atoms from two HEP ligands and one azido ligand, while the other Co(II) atom is coordinated by the same three O atoms, one N atom from an HEP ligand and two azido ligands.	3',5-diazido-2',3'-dideoxyuridine	154-159	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
21589279-2	2010	One Co(II) atom is coordinated by three O atoms from the three 2-hy-droxy-ethyl-pyridine (HEP) bridging ligands, two N atoms from two HEP ligands and one azido ligand, while the other Co(II) atom is coordinated by the same three O atoms, one N atom from an HEP ligand and two azido ligands.	Nitrogen	242-243	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
21589279-2	2010	One Co(II) atom is coordinated by three O atoms from the three 2-hy-droxy-ethyl-pyridine (HEP) bridging ligands, two N atoms from two HEP ligands and one azido ligand, while the other Co(II) atom is coordinated by the same three O atoms, one N atom from an HEP ligand and two azido ligands.	3',5-diazido-2',3'-dideoxyuridine	276-281	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
20104923-2	2010	The Cu(II) and Co(II) complexes were chosen to investigate the impact of the half-filled d orbitals on the photophysical properties of the tetrapyrrole macrocycle.	Tetrapyrroles	139-151	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-21
20728900-1	2010	Self-assembled monodisperse fcc Co(50)Ni(50) and Co(80)Ni(20) alloy nanoparticles with the average size of 25 and 8 nm respectively are synthesized by reductive thermal decomposition of Co(II)(acac)(2) and Ni(II)(acac)(2) in the presence of surfactants such as oleic acid, oleylamine and trioctylphosphine.	co(80)ni	49-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	186-191
20728900-1	2010	Self-assembled monodisperse fcc Co(50)Ni(50) and Co(80)Ni(20) alloy nanoparticles with the average size of 25 and 8 nm respectively are synthesized by reductive thermal decomposition of Co(II)(acac)(2) and Ni(II)(acac)(2) in the presence of surfactants such as oleic acid, oleylamine and trioctylphosphine.	acac)	193-198	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	186-191
21589242-2	2010	The Co(II) ion is penta-coordinated by three O atoms from two 4-meth-oxy-benzoate anions (one bidentate and one monodentate) and two N atoms from two 2,2"-bis-(2-methyl-1H-benzimidazole)-ether ligands.	PENTA	18-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
21589242-2	2010	The Co(II) ion is penta-coordinated by three O atoms from two 4-meth-oxy-benzoate anions (one bidentate and one monodentate) and two N atoms from two 2,2"-bis-(2-methyl-1H-benzimidazole)-ether ligands.	4-anisic acid	62-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
21589242-2	2010	The Co(II) ion is penta-coordinated by three O atoms from two 4-meth-oxy-benzoate anions (one bidentate and one monodentate) and two N atoms from two 2,2"-bis-(2-methyl-1H-benzimidazole)-ether ligands.	2,2"-bis-(2-methyl-1h-benzimidazole)-ether	150-192	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
20853849-11	2010	Furthermore, SAA-induced cholesterol efflux was suppressed when the ERK1/2 pathway or COX-2 was inhibited.	Cholesterol	25-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-91
20967906-3	2010	The solid-state structure of the Co(II)-Borromeate reveals that six MeOH molecules, arranged in a [O--H...O] hydrogen bonded, chair-like conformation, are located within its oxophilic central cavity.	Methanol	68-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-50
20967906-3	2010	The solid-state structure of the Co(II)-Borromeate reveals that six MeOH molecules, arranged in a [O--H...O] hydrogen bonded, chair-like conformation, are located within its oxophilic central cavity.	Hydrogen	109-117	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-50
21060305-2	2010	The lactam 1 showed anti-inflammatory and analgesic activity comparable to that of the COX-2 inhibitor lumiracoxib, without gastro-ulceration effects.	lumiracoxib	103-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-92
20810665-4	2010	We performed a detailed study of naproxen-COX-2 interactions using site-directed mutagenesis, structure-activity analysis, and x-ray crystallography.	Naproxen	33-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47
20810665-8	2010	Crystallization and x-ray analysis yielded structures of COX-2 complexed to naproxen and its methylthio analog at 1.7 and 2.3 A resolution, respectively.	Naproxen	76-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-62
20810665-9	2010	The combination of mutagenesis, structure analysis, and x-ray crystallography provided comprehensive information on the unique interactions responsible for naproxen binding to COX-2.	Naproxen	156-164	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	176-181
21042646-1	2010	Four heterobimetallic U(vi)/M(ii) (M = Mn, Co, Cd) carboxyphosphonates have been synthesized.	co, cd) carboxyphosphonates	43-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-32
20830783-4	2010	The COX-2-specific inhibitor Celecoxib suppressed VEGF-C expression whereas the main COX-2 metabolite PGE(2) elevated VEGF-C expression in Anip973 and AGZY83-a cells in positive and negative experiments.	Celecoxib	29-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
20830783-4	2010	The COX-2-specific inhibitor Celecoxib suppressed VEGF-C expression whereas the main COX-2 metabolite PGE(2) elevated VEGF-C expression in Anip973 and AGZY83-a cells in positive and negative experiments.	Prostaglandins E	102-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-90
20830783-10	2010	The present data suggest that COX-2 regulates VEGF-C expression via the PGE(2) pathway, and that EP1/EP4 receptors are involved in PGE(2)-mediated VEGF-C production.	Prostaglandins E	72-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-35
21110338-1	2010	Pyrazolylbenzotriazinones are endowed with a structural analogy with the COX-2 selective inhibitor celecoxib.	pyrazolylbenzotriazinones	0-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-78
21110338-1	2010	Pyrazolylbenzotriazinones are endowed with a structural analogy with the COX-2 selective inhibitor celecoxib.	Celecoxib	99-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-78
21110338-3	2010	The biological studies revealed a good pharmacological profile for some pyrazolylbenzotriazinones and, in the case of the ethyl 5-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)-1-pyridin-2-yl-1H-pyrazole-4-carboxylate, a good COX-1/COX-2 selectivity.	ethyl 5-(4-oxo-1,2,3-benzotriazin-3(4h)-yl)-1-pyridin-2-yl-1h-pyrazole-4-carboxylate	122-206	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	221-226
20977452-9	2010	In CER-treated animals, but not in those given saline, flavocoxid inhibited COX-2 and 5-LOX expression, reduced serum levels of lipase and amylase and the degree of pancreatic oedema.	flavocoxid	55-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-87
20656057-0	2010	Citral, a component of lemongrass oil, activates PPARalpha and gamma and suppresses COX-2 expression.	citral	0-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-89
20656057-0	2010	Citral, a component of lemongrass oil, activates PPARalpha and gamma and suppresses COX-2 expression.	lemongrass oil	23-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-89
20656057-4	2010	We found that COX-2 promoter activity was suppressed by lemongrass oil in cell-based transfection assays, and we identified citral as a major component in the suppression of COX-2 expression and as an activator of PPARalpha and gamma.	lemongrass oil	56-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
20656057-4	2010	We found that COX-2 promoter activity was suppressed by lemongrass oil in cell-based transfection assays, and we identified citral as a major component in the suppression of COX-2 expression and as an activator of PPARalpha and gamma.	citral	124-130	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
20656057-4	2010	We found that COX-2 promoter activity was suppressed by lemongrass oil in cell-based transfection assays, and we identified citral as a major component in the suppression of COX-2 expression and as an activator of PPARalpha and gamma.	citral	124-130	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	174-179
20656057-5	2010	PPARgamma-dependent suppression of COX-2 promoter activity was observed in response to citral treatment.	citral	87-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40
20656057-6	2010	In human macrophage-like U937 cells, citral suppressed both LPS-induced COX-2 mRNA and protein expression, dose-dependently.	citral	37-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
20656057-7	2010	Moreover, citral induced the mRNA expression of the PPARalpha-responsive carnitine palmitoyltransferase 1 gene and the PPARgamma-responsive fatty acid binding protein 4 gene, suggesting that citral activates PPARalpha and gamma, and regulates COX-2 expression.	citral	10-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	243-248
20656057-7	2010	Moreover, citral induced the mRNA expression of the PPARalpha-responsive carnitine palmitoyltransferase 1 gene and the PPARgamma-responsive fatty acid binding protein 4 gene, suggesting that citral activates PPARalpha and gamma, and regulates COX-2 expression.	citral	191-197	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	243-248
20569079-5	2010	However, the selective COX-2 inhibitor rofecoxib was withdrawn from the market in 2004 after studies had documented an increased risk of myocardial infarction related to this drug.	rofecoxib	39-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-28
20699408-5	2010	It was synthesized as an analog of the known COX-2 inhibitor valdecoxib (4-[5-methyl-3-phenyl-4-isoxazolyl]-benzenesulfonamide) (Talley et al., 2000).	valdecoxib	61-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-50
20699408-5	2010	It was synthesized as an analog of the known COX-2 inhibitor valdecoxib (4-[5-methyl-3-phenyl-4-isoxazolyl]-benzenesulfonamide) (Talley et al., 2000).	valdecoxib	73-126	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-50
20699408-6	2010	N-Hydroxy-valdecoxib had low in vitro COX-2 activity but showed significant analgesic activity in vivo and a prolonged therapeutic effect compared with valdecoxib (Erdelyi et al., 2008).	N-hydroxy-valdecoxib	0-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-43
20699408-6	2010	N-Hydroxy-valdecoxib had low in vitro COX-2 activity but showed significant analgesic activity in vivo and a prolonged therapeutic effect compared with valdecoxib (Erdelyi et al., 2008).	valdecoxib	10-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-43
20828891-9	2010	Only the Prop-Cp-ASS-Rh complex (10 muM) caused an important inhibition of COX-1 by 60% and COX-2 by 30%.	prop-cp-ass-rh	9-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-97
20801552-7	2010	Our data also provide evidence that the COX-active metabolite of sulindac hydroxamic acid were the most active of the series and selective inhibition of COX-1 but not COX-2 can mimic its effects, suggesting that COX inhibition could only play a partial role in the mechanism of compound action.	sulindac hydroxamic acid	65-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	167-172
22111779-6	2010	These data informed the "imbalance hypothesis" that the cardiovascular risk of NSAIDs results from an imbalance in the detrimental actions of COX-1-derived thromboxane A(2) and the beneficial actions of COX-2-derived prostacyclin (PGI(2)).	Epoprostenol	217-229	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	203-208
20815659-4	2010	U0126 differentially affected cyclooxygenase (COX)-1, COX-2, and inducible NO synthase (iNOS) expression in cell lines, however, suggesting that MEK1/2 regulates prostanoid and NO production by means other than inducing their biosynthetic enzymes.	U 0126	0-5	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-59
20506110-7	2010	PA-induced activation of CB(1)R is prevented by the treatment of AACOCF(3) (a cPLA(2) inhibitor), indomethacin and NS398 (a COX 2 inhibitors).	Palmitic Acid	0-2	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	124-129
20506110-8	2010	Indeed, PA increased cPLA(2), and COX-2 but not COX-1.	Palmitic Acid	8-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-39
20386089-9	2010	The VDR agonist elocalcitol partially reverts COX-2 and IL-8 mRNA upregulation induced by a pro-inflammatory cytokine mixture (IL-17, interferon-gamma, tumor necrosis factor-alpha) and inhibits cell migration in urethral cells.	BXL628	16-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
20958135-8	2010	Another selective COX-2 inhibitor, celecoxib, did not show potent inhibitory effects as strong as those of NS-398.	Celecoxib	35-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-23
20833102-0	2010	Spectroscopic, magnetic and thermal studies of Co(II), Ni(II), Cu(II) and Zn(II) complexes of 3-acetylcoumarin-isonicotinoylhydrazone and their antimicrobial and anti-tubercular activity evaluation.	Zinc	74-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-53
20833102-0	2010	Spectroscopic, magnetic and thermal studies of Co(II), Ni(II), Cu(II) and Zn(II) complexes of 3-acetylcoumarin-isonicotinoylhydrazone and their antimicrobial and anti-tubercular activity evaluation.	3-acetylcoumarin-isonicotinoylhydrazone	94-133	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-53
20833102-1	2010	Co(II), Ni(II), Cu(II) and Zn(II) complexes with a new heterocyclic Schiff base derived by the condensation of isonicotinoylhydrazide and 3-acetylcoumarin have been synthesized.	Zinc	27-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
20833102-1	2010	Co(II), Ni(II), Cu(II) and Zn(II) complexes with a new heterocyclic Schiff base derived by the condensation of isonicotinoylhydrazide and 3-acetylcoumarin have been synthesized.	Schiff Bases	68-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
20833102-1	2010	Co(II), Ni(II), Cu(II) and Zn(II) complexes with a new heterocyclic Schiff base derived by the condensation of isonicotinoylhydrazide and 3-acetylcoumarin have been synthesized.	(1,1-difluoro-1-((6-carboxy)naphth-2-yl))methylphosphonic acid	111-133	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
20833102-1	2010	Co(II), Ni(II), Cu(II) and Zn(II) complexes with a new heterocyclic Schiff base derived by the condensation of isonicotinoylhydrazide and 3-acetylcoumarin have been synthesized.	3-acetylcoumarin	138-154	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
20833102-8	2010	Anti-TB activity of the ligand has enhanced on complexation with Co(II) and Ni(II) ions.	Terbium	5-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-71
21138631-6	2010	Trypan blue exclusion was performed to examine the inhibitory effects of COX-2 selective inhibitor (celecoxib).	Celecoxib	100-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-78
20820611-3	2010	With LiOMe/pyridine as base in MeOH a dinuclear cobalt cage, [Co(2)(SbAr)(4)O(4)(O(3)PPh)(4)(OMe)(4)py(2)] 3, is formed, with four Sb(ii) and two Co(ii) centres bridged by mu(3)-oxides and phosphonates.	Cobalt	48-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-136
20820611-3	2010	With LiOMe/pyridine as base in MeOH a dinuclear cobalt cage, [Co(2)(SbAr)(4)O(4)(O(3)PPh)(4)(OMe)(4)py(2)] 3, is formed, with four Sb(ii) and two Co(ii) centres bridged by mu(3)-oxides and phosphonates.	Cobalt	48-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	146-152
20820611-3	2010	With LiOMe/pyridine as base in MeOH a dinuclear cobalt cage, [Co(2)(SbAr)(4)O(4)(O(3)PPh)(4)(OMe)(4)py(2)] 3, is formed, with four Sb(ii) and two Co(ii) centres bridged by mu(3)-oxides and phosphonates.	co(2)(sbar)(4)o(4)(o(3)pph)(4)(ome)(4)py(2)] 3	62-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-136
20820611-3	2010	With LiOMe/pyridine as base in MeOH a dinuclear cobalt cage, [Co(2)(SbAr)(4)O(4)(O(3)PPh)(4)(OMe)(4)py(2)] 3, is formed, with four Sb(ii) and two Co(ii) centres bridged by mu(3)-oxides and phosphonates.	co(2)(sbar)(4)o(4)(o(3)pph)(4)(ome)(4)py(2)] 3	62-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	146-152
20820611-7	2010	With Et(3)N/pyridine as base in MeCN a tetranuclear cobalt cage, [Co(4)(SbAr)(5)O(9)(O(3)PPh)(6)(py)(4)] 13, with five Sb(ii) centres forming a "bowtie" and bridging to four Co(ii) centres by phosphonates and mu(3)-oxides, is formed.	Cobalt	52-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-124
20820611-7	2010	With Et(3)N/pyridine as base in MeCN a tetranuclear cobalt cage, [Co(4)(SbAr)(5)O(9)(O(3)PPh)(6)(py)(4)] 13, with five Sb(ii) centres forming a "bowtie" and bridging to four Co(ii) centres by phosphonates and mu(3)-oxides, is formed.	Cobalt	52-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	174-180
20820611-7	2010	With Et(3)N/pyridine as base in MeCN a tetranuclear cobalt cage, [Co(4)(SbAr)(5)O(9)(O(3)PPh)(6)(py)(4)] 13, with five Sb(ii) centres forming a "bowtie" and bridging to four Co(ii) centres by phosphonates and mu(3)-oxides, is formed.	co(4)(sbar)	66-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-124
20820611-7	2010	With Et(3)N/pyridine as base in MeCN a tetranuclear cobalt cage, [Co(4)(SbAr)(5)O(9)(O(3)PPh)(6)(py)(4)] 13, with five Sb(ii) centres forming a "bowtie" and bridging to four Co(ii) centres by phosphonates and mu(3)-oxides, is formed.	co(4)(sbar)	66-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	174-180
20820611-8	2010	The reaction of 2 with cobalt acetate using LiOMe/pyridine as base in methanol, under solvothermal conditions, produces a dinuclear Co(ii) complex, [Co(2)(SbAr)(2)(O(3)P(t)Bu)(3)O(2)(OMe)(2)(py)(2)] 14, with two Co(II) and two Sb centres at the vertices of a distorted tetrahedron.	cobalt(II) acetate	23-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-138
20820611-8	2010	The reaction of 2 with cobalt acetate using LiOMe/pyridine as base in methanol, under solvothermal conditions, produces a dinuclear Co(ii) complex, [Co(2)(SbAr)(2)(O(3)P(t)Bu)(3)O(2)(OMe)(2)(py)(2)] 14, with two Co(II) and two Sb centres at the vertices of a distorted tetrahedron.	cobalt(II) acetate	23-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	212-218
20820611-8	2010	The reaction of 2 with cobalt acetate using LiOMe/pyridine as base in methanol, under solvothermal conditions, produces a dinuclear Co(ii) complex, [Co(2)(SbAr)(2)(O(3)P(t)Bu)(3)O(2)(OMe)(2)(py)(2)] 14, with two Co(II) and two Sb centres at the vertices of a distorted tetrahedron.	Lithium methoxide	44-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-138
20820611-8	2010	The reaction of 2 with cobalt acetate using LiOMe/pyridine as base in methanol, under solvothermal conditions, produces a dinuclear Co(ii) complex, [Co(2)(SbAr)(2)(O(3)P(t)Bu)(3)O(2)(OMe)(2)(py)(2)] 14, with two Co(II) and two Sb centres at the vertices of a distorted tetrahedron.	Lithium methoxide	44-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	212-218
20820611-8	2010	The reaction of 2 with cobalt acetate using LiOMe/pyridine as base in methanol, under solvothermal conditions, produces a dinuclear Co(ii) complex, [Co(2)(SbAr)(2)(O(3)P(t)Bu)(3)O(2)(OMe)(2)(py)(2)] 14, with two Co(II) and two Sb centres at the vertices of a distorted tetrahedron.	pyridine	50-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-138
20820611-8	2010	The reaction of 2 with cobalt acetate using LiOMe/pyridine as base in methanol, under solvothermal conditions, produces a dinuclear Co(ii) complex, [Co(2)(SbAr)(2)(O(3)P(t)Bu)(3)O(2)(OMe)(2)(py)(2)] 14, with two Co(II) and two Sb centres at the vertices of a distorted tetrahedron.	pyridine	50-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	212-218
20820611-8	2010	The reaction of 2 with cobalt acetate using LiOMe/pyridine as base in methanol, under solvothermal conditions, produces a dinuclear Co(ii) complex, [Co(2)(SbAr)(2)(O(3)P(t)Bu)(3)O(2)(OMe)(2)(py)(2)] 14, with two Co(II) and two Sb centres at the vertices of a distorted tetrahedron.	Methanol	70-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-138
20820611-8	2010	The reaction of 2 with cobalt acetate using LiOMe/pyridine as base in methanol, under solvothermal conditions, produces a dinuclear Co(ii) complex, [Co(2)(SbAr)(2)(O(3)P(t)Bu)(3)O(2)(OMe)(2)(py)(2)] 14, with two Co(II) and two Sb centres at the vertices of a distorted tetrahedron.	Methanol	70-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	212-218
20820611-8	2010	The reaction of 2 with cobalt acetate using LiOMe/pyridine as base in methanol, under solvothermal conditions, produces a dinuclear Co(ii) complex, [Co(2)(SbAr)(2)(O(3)P(t)Bu)(3)O(2)(OMe)(2)(py)(2)] 14, with two Co(II) and two Sb centres at the vertices of a distorted tetrahedron.	co(2)(sbar)	149-160	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-138
20820611-8	2010	The reaction of 2 with cobalt acetate using LiOMe/pyridine as base in methanol, under solvothermal conditions, produces a dinuclear Co(ii) complex, [Co(2)(SbAr)(2)(O(3)P(t)Bu)(3)O(2)(OMe)(2)(py)(2)] 14, with two Co(II) and two Sb centres at the vertices of a distorted tetrahedron.	co(2)(sbar)	149-160	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	212-218
20820611-8	2010	The reaction of 2 with cobalt acetate using LiOMe/pyridine as base in methanol, under solvothermal conditions, produces a dinuclear Co(ii) complex, [Co(2)(SbAr)(2)(O(3)P(t)Bu)(3)O(2)(OMe)(2)(py)(2)] 14, with two Co(II) and two Sb centres at the vertices of a distorted tetrahedron.	2)(o(3)p(t)bu)(3)o(2)(ome)(2)(py)(2)	161-197	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-138
20820611-8	2010	The reaction of 2 with cobalt acetate using LiOMe/pyridine as base in methanol, under solvothermal conditions, produces a dinuclear Co(ii) complex, [Co(2)(SbAr)(2)(O(3)P(t)Bu)(3)O(2)(OMe)(2)(py)(2)] 14, with two Co(II) and two Sb centres at the vertices of a distorted tetrahedron.	Antimony	155-157	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-138
20820611-8	2010	The reaction of 2 with cobalt acetate using LiOMe/pyridine as base in methanol, under solvothermal conditions, produces a dinuclear Co(ii) complex, [Co(2)(SbAr)(2)(O(3)P(t)Bu)(3)O(2)(OMe)(2)(py)(2)] 14, with two Co(II) and two Sb centres at the vertices of a distorted tetrahedron.	Antimony	155-157	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	212-218
20522791-7	2010	The increase in PGE2 depended on induction of COX-2, which increased to a greater degree in fibroblasts from subjects with COPD.	Dinoprostone	16-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
20619964-1	2010	A separation-preconcentration procedure was developed for the determination of trace amounts of aluminium in water samples and dialysis concentrates by UV-vis Spectrophotometry after coprecipitation using 8-hydroxyquinoline (8-HQ) as a chelating agent and Co(II) as a carrier element.	Aluminum	96-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	256-262
21112464-3	2010	Here, we present the case of an elderly depressed woman with acute cognitive deficit who was refractory to multiple antidepressants but only responsive to celecoxib, a COX-2 inhibitor, in acute treatment and sustaining remission for a 5-year treatment course.	Celecoxib	155-164	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	168-173
20878062-8	2010	Indomethacin did not change overall COX-2 staining in tumor tissue, but altered its distribution towards increased staining in cell nuclei/nucleoli and decreased COX-2 staining heterogeneity in tumor tissue.	Indomethacin	0-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	162-167
20878062-9	2010	P53 staining was decreased, while PCNA and TGFbeta3 staining were increased by indomethacin in tumor areas with high presence of COX-2, which correlated to staining of BAX, TUNEL, Bcl-2, c-jun, p21, p27, p53 and NM23.	Indomethacin	79-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-134
21056807-14	2010	Diclofenac, with its balanced COX-1 and COX-2 inhibitory profile, may pose less risk of postoperative bleeding than nonsteroidal antiinflammatory drugs (NSAIDs) such as ketorolac and ASA, which predominantly inhibit COX-1.	Diclofenac	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
20958135-3	2010	We aimed at evaluating the effects of the selective COX-2 inhibitor NS-398 on human ureteral smooth muscle contractility and compare its potency with that of nonselective COX inhibitors, COX-1 inhibitors, and other COX-2 inhibitors.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	68-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-57
20587738-5	2010	The tumor-mediated inhibition of APC differentiation was associated with the up-regulated expression of PGE2-forming enzymes COX-2, mPGES1 in myeloid cells, and the simultaneous repression of PGE(2)-catabolizing enzyme 15-PGDH.	Dinoprostone	104-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-130
20708014-8	2010	Furthermore, inhibition of COX-2 activity by either NS-398 or DUP-697 partially offset protective effects of the miR-144/451 cluster.	Nitrogen	52-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-32
21472340-0	2010	Renal cell carcinoma may evade the immune system by converting CD4+Foxp3- T cells into CD4+CD25+Foxp3+ regulatory T cells: Role of tumor COX-2-derived PGE2.	Dinoprostone	151-155	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-142
21472340-6	2010	The results showed that overexpression of COX-2 in OS-RC-2 cells led to higher expression of prostaglandin E2 (PGE2) in the culture medium supernatants.	Dinoprostone	93-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47
21472340-6	2010	The results showed that overexpression of COX-2 in OS-RC-2 cells led to higher expression of prostaglandin E2 (PGE2) in the culture medium supernatants.	Dinoprostone	111-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47
20886180-7	2010	Plaque macrophages synthesise PGH2/PGG2 via COX-2; these potent prostanoids can trigger platelet activation and aggregation despite COX-1 inhibition by aspirin.	Prostaglandin H2	30-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-49
20886180-7	2010	Plaque macrophages synthesise PGH2/PGG2 via COX-2; these potent prostanoids can trigger platelet activation and aggregation despite COX-1 inhibition by aspirin.	prostaglandin G2	35-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-49
20886180-7	2010	Plaque macrophages synthesise PGH2/PGG2 via COX-2; these potent prostanoids can trigger platelet activation and aggregation despite COX-1 inhibition by aspirin.	Prostaglandins	64-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-49
21215211-8	2010	RT-PCR showed that celecoxib reduced the expression of Cox-2 mRNA expression in 25, 50 micromol/L group decreased significantly compared with the control group (respectively, t were 23.950 and 36.651, P &lt; 0.01), but it enhanced the expression of E-cadherin mRNA expression in 25, 50 micromol/L group was significantly higher (respectively, t were 35.829 and 81.497, P &lt; 0.01).	Celecoxib	19-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-60
21060890-0	2010	Antioxidant biomarkers from Vanda coerulea stems reduce irradiated HaCaT PGE-2 production as a result of COX-2 inhibition.	Dinoprostone	73-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-110
21060890-9	2010	Western blot analysis revealed that stilbenoids (1-3) inhibited COX-2 expression at 23 microM.	stilbenoids	36-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-69
21060890-10	2010	Interestingly, stilbenoids (1) and (2) but not (3) were able to inhibit human recombinant COX-2 activity.	stilbenoids	15-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-95
21060890-11	2010	CONCLUSIONS: Major antioxidant stilbenoids (1-3) from Vanda coerulea stems displayed an inhibition of UV(B)-induced COX-2 expression.	stilbenoids	31-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-121
21060890-12	2010	Imbricatin (1) and methoxycoelonin (2) were also able to inhibit COX-2 activity in a concentration-dependent manner thereby reducing PGE-2 production from irradiated HaCaT cells.	methoxycoelonin	19-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-70
21060890-12	2010	Imbricatin (1) and methoxycoelonin (2) were also able to inhibit COX-2 activity in a concentration-dependent manner thereby reducing PGE-2 production from irradiated HaCaT cells.	Dinoprostone	133-138	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-70
20866049-3	2010	We determined how Fe(II) substrates can access catalytic sites using frog M ferritins, active and inactivated by ligand substitution, crystallized with 2.0 M Mg(II) +- 0.1 M Co(II) for Co(II)-selective sites.	ammonium ferrous sulfate	18-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	174-180
20866049-3	2010	We determined how Fe(II) substrates can access catalytic sites using frog M ferritins, active and inactivated by ligand substitution, crystallized with 2.0 M Mg(II) +- 0.1 M Co(II) for Co(II)-selective sites.	ammonium ferrous sulfate	18-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	185-191
20866049-4	2010	Co(II) inhibited Fe(II) oxidation.	ammonium ferrous sulfate	17-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
20615388-5	2010	This event was mediated by COX-2 gene transcription, and abrogated by compound C and 5"-iodotubercidin, suggesting the essential role of AMPK in COX-2 induction.	5-iodotubercidin	85-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-150
20506110-7	2010	PA-induced activation of CB(1)R is prevented by the treatment of AACOCF(3) (a cPLA(2) inhibitor), indomethacin and NS398 (a COX 2 inhibitors).	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	115-120	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	124-129
20831162-5	2010	Based on the enthalpy, a weak N(2) interaction with the open Co(II) coordination sites is proposed for the first four phases, which is supported by Monte Carlo simulations.	Nitrogen	30-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-66
20845002-9	2010	CONCLUSION: Flavocoxid, a first-in-class flavonoid-based therapeutic that inhibits COX-1 and COX-2 as well as 5-LOX, was as effective as naproxen in managing the signs and symptoms of OA of the knee.	flavocoxid	12-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-98
20804139-3	2010	An intramolecular Co(II)   Re(IV) charge-transfer accompanies the formation of the Co(II)(4)Re(IV) cluster, giving a Co(II)(3)Co(III)Re(III) species.	)co(iii)	125-133	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-24
20804139-3	2010	An intramolecular Co(II)   Re(IV) charge-transfer accompanies the formation of the Co(II)(4)Re(IV) cluster, giving a Co(II)(3)Co(III)Re(III) species.	)co(iii)	125-133	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-89
20804139-3	2010	An intramolecular Co(II)   Re(IV) charge-transfer accompanies the formation of the Co(II)(4)Re(IV) cluster, giving a Co(II)(3)Co(III)Re(III) species.	)co(iii)	125-133	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-89
20729081-5	2010	The difluoro derivatives were found to be most effective against human pancreatic BxPC-3 cancer cells which possess up-regulated COX-2 expression and also showed activity against human breast cancer BT-20 cells with triple negative phenotype, suggesting that these compounds will have broader application in the future.	methylphosphonic difluoride	4-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-134
20707612-3	2010	An early diagnostic test on the action of TCDD on HepG2 cells in vitro within 3-6 h indicated that Cox-2 and SOCS3 are mainly induced via a non-genomic route, whereas PAI-2 appears to be induced through the classical action route.	Polychlorinated Dibenzodioxins	42-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-104
20727750-3	2010	These structure-activity data indicate replacement of the 4-chlorobenzoyl group present in indomethacin by a N-difluoromethyl-1,2-dihydropyrid-2-one ring system connected by a CO or CH(2) linker is not a suitable approach for the design of dual COX-2/5-LOX inhibitory analogs of indomethacin.	Indomethacin	91-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	245-250
20883058-6	2010	NSAIDs currently available in the US fall into three categories: nonselective NSAIDs that act via inhibition of cyclo-oxygenase (COX)-1 and COX-2; celecoxib, a selective inhibitor of COX-2; and topical NSAIDs that inhibit both COX-1 and COX-2 but result in much less systemic NSAID exposure than oral formulations.	Celecoxib	147-156	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	183-188
20883058-6	2010	NSAIDs currently available in the US fall into three categories: nonselective NSAIDs that act via inhibition of cyclo-oxygenase (COX)-1 and COX-2; celecoxib, a selective inhibitor of COX-2; and topical NSAIDs that inhibit both COX-1 and COX-2 but result in much less systemic NSAID exposure than oral formulations.	Celecoxib	147-156	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	183-188
20691240-0	2010	The dietary flavonoid apigenin blocks phorbol 12-myristate 13-acetate-induced COX-2 transcriptional activity in breast cell lines.	Tetradecanoylphorbol Acetate	38-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-83
20691240-1	2010	Cyclooxygenase (COX)-2 is the inducible isozyme catalyzing the conversion of arachidonic acid to prostanoids.	Arachidonic Acid	77-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-22
20691240-1	2010	Cyclooxygenase (COX)-2 is the inducible isozyme catalyzing the conversion of arachidonic acid to prostanoids.	Prostaglandins	97-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-22
20691240-4	2010	This study examined the potential suppressive effect of the flavone on phorbol ester-induced COX-2 expression in the breast cell lines MCF-10A and MCF-7.	flavone	60-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-98
20691240-4	2010	This study examined the potential suppressive effect of the flavone on phorbol ester-induced COX-2 expression in the breast cell lines MCF-10A and MCF-7.	Phorbol Esters	71-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-98
20691240-5	2010	Real-time PCR and/or Western blotting indicated that APG in micromolar range significantly inhibited phorbol 12-myristate 13-acetate (PMA)-induced COX-2 expression in these breast cells.	Tetradecanoylphorbol Acetate	101-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-152
20691240-5	2010	Real-time PCR and/or Western blotting indicated that APG in micromolar range significantly inhibited phorbol 12-myristate 13-acetate (PMA)-induced COX-2 expression in these breast cells.	Tetradecanoylphorbol Acetate	134-137	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-152
20840388-7	2010	In ex vivo COX isoform inhibition assays, orally (1-2 mg/kg) or subcutaneously (2 mg/kg) administered robenacoxib significantly inhibited COX-2, with a relatively short duration of action in the central compartment, and had no effect on COX-1.	robenacoxib	102-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	138-143
20840388-8	2010	Therefore robenacoxib was COX-2 selective and spared COX-1 in vivo.	robenacoxib	10-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-31
20840388-9	2010	In contrast, meloxicam (0.3 mg/kg via subcutaneous injection) inhibited both COX-1 and COX-2 isoforms significantly for at least 24 h, indicating nonselectivity in vivo.	Meloxicam	13-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-92
20600307-8	2010	The protective effect of EPA on osteoblastogenesis could be mediated by the biphasic cross-talk between PGE(2) and NO production involving COX-2 and iNOS pathways.	Eicosapentaenoic Acid	25-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-144
21180996-1	2010	OBJECTIVE: To evaluate the immunohistochemical expression of cox-2 before primary chemotherapy with 5-fluorouracil, epirubicin and cyclophosphamide (FEC) and its association with initial tumor size, lymph node status, hormone receptors, expression of HER2 and the clinical and pathological response in patients with breast cancer.	Fluorouracil	100-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-66
21180996-1	2010	OBJECTIVE: To evaluate the immunohistochemical expression of cox-2 before primary chemotherapy with 5-fluorouracil, epirubicin and cyclophosphamide (FEC) and its association with initial tumor size, lymph node status, hormone receptors, expression of HER2 and the clinical and pathological response in patients with breast cancer.	Epirubicin	116-126	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-66
21180996-1	2010	OBJECTIVE: To evaluate the immunohistochemical expression of cox-2 before primary chemotherapy with 5-fluorouracil, epirubicin and cyclophosphamide (FEC) and its association with initial tumor size, lymph node status, hormone receptors, expression of HER2 and the clinical and pathological response in patients with breast cancer.	Cyclophosphamide	131-147	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-66
20633634-3	2010	IL-8 secretion and PGE-2 synthesizing capacity were dose-dependently upregulated in differentiated Caco-2 cells exposed to DON during 24h, reaching an increase of ~25 and 1.7-fold respectively, whereas transcript level of IL-8 and COX-2 were increased by ~40 and 17-fold.	deoxynivalenol	123-126	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	231-236
20828117-12	2010	The value of lifetime increases at the micromolar level of concentration of the Co(II) ion, where the intensity increases and then remains practically unchanged as more salt is added to the system.	Salts	169-173	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-86
21176579-1	2010	OBJECTIVE: To investigate the effects of Nimesulide, a selective Cox-2 inhibitor, on the apoptosis, invasion and migration of hypopharyngeal carcinoma cell line (FaDu).	nimesulide	41-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-70
21176579-6	2010	The mRNA and protein expressions of Cox-2, MMP-9 and caspase-3 in response to Nimesulide were examined by RT-PCR and Western blot, respectively.	nimesulide	78-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-41
21176579-11	2010	Nimesulide decreased the expressions of Cox-2 and MMP-9, whereas increased expression the of Caspase-3.	nimesulide	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
20715794-6	2010	Zn(II)-loaded R246H GLX2-1 enzyme bound 2 equiv of Zn(II), and (1)H NMR spectra of the Co(II)-substituted analogue of this enzyme strongly suggest that the introduced histidine binds to Co(II).	Zinc	0-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-92
20715794-6	2010	Zn(II)-loaded R246H GLX2-1 enzyme bound 2 equiv of Zn(II), and (1)H NMR spectra of the Co(II)-substituted analogue of this enzyme strongly suggest that the introduced histidine binds to Co(II).	Zinc	0-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-93
20715794-6	2010	Zn(II)-loaded R246H GLX2-1 enzyme bound 2 equiv of Zn(II), and (1)H NMR spectra of the Co(II)-substituted analogue of this enzyme strongly suggest that the introduced histidine binds to Co(II).	Zinc	51-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-92
20715794-6	2010	Zn(II)-loaded R246H GLX2-1 enzyme bound 2 equiv of Zn(II), and (1)H NMR spectra of the Co(II)-substituted analogue of this enzyme strongly suggest that the introduced histidine binds to Co(II).	Zinc	51-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-93
20715794-6	2010	Zn(II)-loaded R246H GLX2-1 enzyme bound 2 equiv of Zn(II), and (1)H NMR spectra of the Co(II)-substituted analogue of this enzyme strongly suggest that the introduced histidine binds to Co(II).	Histidine	167-176	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-92
20715794-6	2010	Zn(II)-loaded R246H GLX2-1 enzyme bound 2 equiv of Zn(II), and (1)H NMR spectra of the Co(II)-substituted analogue of this enzyme strongly suggest that the introduced histidine binds to Co(II).	Histidine	167-176	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-93
20664853-1	2010	Nitric oxide (NO) and its reduced form nitroxyl (HNO), effective vasodilation agents that can inhibit platelet aggregation and adhesion, could suppress adverse cardiovascular effects associated with the use of selective COX-2 inhibitors.	Nitric Oxide	0-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	220-225
20664853-1	2010	Nitric oxide (NO) and its reduced form nitroxyl (HNO), effective vasodilation agents that can inhibit platelet aggregation and adhesion, could suppress adverse cardiovascular effects associated with the use of selective COX-2 inhibitors.	nitroxyl	39-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	220-225
20664853-1	2010	Nitric oxide (NO) and its reduced form nitroxyl (HNO), effective vasodilation agents that can inhibit platelet aggregation and adhesion, could suppress adverse cardiovascular effects associated with the use of selective COX-2 inhibitors.	nitroxyl	49-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	220-225
20664853-2	2010	In this regard, a sulfohydroxamic acid (SO(2)NHOH) substituent, that can act as a dual NO/HNO donor moiety, was inserted at the para-position of the C2 phenyl ring of acyclic 2-alkyl-1,1,2-triaryl olefins previously shown to be potent and highly selective COX-2 inhibitors.	sulfohydroxamic acid	18-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	256-261
20795645-0	2010	Mixed azide and 5-(pyrimidyl)tetrazole bridged Co(II)/Mn(II) polymers: synthesis, crystal structures, ferroelectric and magnetic behavior.	2-(1H-Tetrazol-5-yl)pyrimidine	16-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-53
20542378-1	2010	2,4-Dinitrophenylhydrazine (DNPH) immobilized on sodium dodecyl sulfate coated nano-alumina was developed for the removal of metal cations Pb(II), Cd(II), Cr(III), Co(II), Ni(II) and Mn(II) from water samples.	2,4-dinitrophenylhydrazine	0-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	164-170
20542378-1	2010	2,4-Dinitrophenylhydrazine (DNPH) immobilized on sodium dodecyl sulfate coated nano-alumina was developed for the removal of metal cations Pb(II), Cd(II), Cr(III), Co(II), Ni(II) and Mn(II) from water samples.	2,4-dinitrophenylhydrazine	28-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	164-170
20542378-1	2010	2,4-Dinitrophenylhydrazine (DNPH) immobilized on sodium dodecyl sulfate coated nano-alumina was developed for the removal of metal cations Pb(II), Cd(II), Cr(III), Co(II), Ni(II) and Mn(II) from water samples.	Sodium Dodecyl Sulfate	49-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	164-170
20542378-1	2010	2,4-Dinitrophenylhydrazine (DNPH) immobilized on sodium dodecyl sulfate coated nano-alumina was developed for the removal of metal cations Pb(II), Cd(II), Cr(III), Co(II), Ni(II) and Mn(II) from water samples.	Aluminum Oxide	84-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	164-170
20657935-0	2010	Click on silica: systematic immobilization of Co(II) Schiff bases to the mesoporous silica via click reaction and their catalytic activity for aerobic oxidation of alcohols.	Silicon Dioxide	9-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
20657935-0	2010	Click on silica: systematic immobilization of Co(II) Schiff bases to the mesoporous silica via click reaction and their catalytic activity for aerobic oxidation of alcohols.	Schiff Bases	53-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
20704327-5	2010	Magnetic studies reveal that the mixed (mu-EO-N(3))(mu-COO)(2) triple bridges transmit ferromagnetic coupling in the Co(II) compound, and the overall antiferromagnetic interactions exist in the Mn(II) compound.	mu-eo-n(3))	40-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-123
20704327-5	2010	Magnetic studies reveal that the mixed (mu-EO-N(3))(mu-COO)(2) triple bridges transmit ferromagnetic coupling in the Co(II) compound, and the overall antiferromagnetic interactions exist in the Mn(II) compound.	mu-coo	52-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-123
20688044-9	2010	COX-2 downregulation by E5 could be overcome by thapsigargin or tunicamycin treatments, which initiate ER stress via calcium fluxes and abnormal protein glycosylation respectively, making it unlikely that E5 specifically tempers these pathways.	Thapsigargin	48-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
20688044-9	2010	COX-2 downregulation by E5 could be overcome by thapsigargin or tunicamycin treatments, which initiate ER stress via calcium fluxes and abnormal protein glycosylation respectively, making it unlikely that E5 specifically tempers these pathways.	Tunicamycin	64-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
20688044-9	2010	COX-2 downregulation by E5 could be overcome by thapsigargin or tunicamycin treatments, which initiate ER stress via calcium fluxes and abnormal protein glycosylation respectively, making it unlikely that E5 specifically tempers these pathways.	Calcium	117-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
20692174-2	2010	The 2-oxo-5H-furan derivative 6b was identified as potent COX inhibitor with selectivity toward COX-1 (COX-1 IC(50)=0.061 microM and COX-2 IC(50)=0.325 microM; selectivity index (SI)=0.19).	2-oxo-5h-furan	4-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	133-138
20692174-3	2010	Among the 1H-pyrazole derivatives, 11b was found to be a potent COX-2 inhibitor, about 38 times more potent than Rofecoxib (COX-2 IC(50)=0.011 microM and 0.398 microM, respectively), but showed no selectivity for COX-2 isoform.	pyrazole	10-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-69
20692174-3	2010	Among the 1H-pyrazole derivatives, 11b was found to be a potent COX-2 inhibitor, about 38 times more potent than Rofecoxib (COX-2 IC(50)=0.011 microM and 0.398 microM, respectively), but showed no selectivity for COX-2 isoform.	rofecoxib	113-122	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-69
20692174-3	2010	Among the 1H-pyrazole derivatives, 11b was found to be a potent COX-2 inhibitor, about 38 times more potent than Rofecoxib (COX-2 IC(50)=0.011 microM and 0.398 microM, respectively), but showed no selectivity for COX-2 isoform.	rofecoxib	113-122	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	124-129
20692174-3	2010	Among the 1H-pyrazole derivatives, 11b was found to be a potent COX-2 inhibitor, about 38 times more potent than Rofecoxib (COX-2 IC(50)=0.011 microM and 0.398 microM, respectively), but showed no selectivity for COX-2 isoform.	rofecoxib	113-122	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	124-129
20718752-10	2010	Non-selective and selective COX-2 inhibitors, indomethacin and NS398, inhibited CIP-induced PGE(2) and cAMP production.	Indomethacin	46-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
20718752-10	2010	Non-selective and selective COX-2 inhibitors, indomethacin and NS398, inhibited CIP-induced PGE(2) and cAMP production.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	63-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
20718752-10	2010	Non-selective and selective COX-2 inhibitors, indomethacin and NS398, inhibited CIP-induced PGE(2) and cAMP production.	Prostaglandins E	92-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
20718752-10	2010	Non-selective and selective COX-2 inhibitors, indomethacin and NS398, inhibited CIP-induced PGE(2) and cAMP production.	Cyclic AMP	103-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
20691338-0	2010	Design, synthesis and biological evaluation of new (E)- and (Z)-1,2,3-triaryl-2-propen-1-ones as selective COX-2 inhibitors.	(e)- and	51-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-112
20691338-0	2010	Design, synthesis and biological evaluation of new (E)- and (Z)-1,2,3-triaryl-2-propen-1-ones as selective COX-2 inhibitors.	(z)-1,2,3-triaryl-2-propen-1-ones	60-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-112
20691338-1	2010	A group of (E)-and (Z)-1,2,3-triaryl-2-propen-1-one derivatives possessing a methylsulfonyl COX-2 pharmacophore at the para position of the C-1 phenyl ring were synthesized and evaluated as selective COX-2 inhibitors.	1,2,3-triaryl-2-propen-1-one	23-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-97
20691338-1	2010	A group of (E)-and (Z)-1,2,3-triaryl-2-propen-1-one derivatives possessing a methylsulfonyl COX-2 pharmacophore at the para position of the C-1 phenyl ring were synthesized and evaluated as selective COX-2 inhibitors.	1,2,3-triaryl-2-propen-1-one	23-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	200-205
20537435-0	2010	Chiral preference of L-tryptophan derived metal-based antitumor agent of late 3d-metal ions (Co(II), Cu(II) and Zn(II)) in comparison to D- and DL-tryptophan analogues: their in vitro reactivity towards CT DNA, 5"-GMP and 5"-TMP.	Tryptophan	21-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-98
20537435-0	2010	Chiral preference of L-tryptophan derived metal-based antitumor agent of late 3d-metal ions (Co(II), Cu(II) and Zn(II)) in comparison to D- and DL-tryptophan analogues: their in vitro reactivity towards CT DNA, 5"-GMP and 5"-TMP.	Metals	42-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-98
20537435-0	2010	Chiral preference of L-tryptophan derived metal-based antitumor agent of late 3d-metal ions (Co(II), Cu(II) and Zn(II)) in comparison to D- and DL-tryptophan analogues: their in vitro reactivity towards CT DNA, 5"-GMP and 5"-TMP.	Metals	81-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-98
19815191-2	2010	Prostaglandins are produced after the sequential oxidation of arachidonic acid by cyclooxygenases (COX-1 and COX-2) and terminal PG synthases.	Prostaglandins	0-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-114
19815191-2	2010	Prostaglandins are produced after the sequential oxidation of arachidonic acid by cyclooxygenases (COX-1 and COX-2) and terminal PG synthases.	Arachidonic Acid	62-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-114
20664959-8	2010	In contrast, TSN treated with either CC-10 or NS398 (COX-2 inhibitor) stimulated Th1 type and inhibited Th2 type without any phenotypic changes.	trichostatin A	13-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-58
20664959-8	2010	In contrast, TSN treated with either CC-10 or NS398 (COX-2 inhibitor) stimulated Th1 type and inhibited Th2 type without any phenotypic changes.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	46-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-58
21535545-6	2010	Otherwise, all tested flavonoids possessed the inhibitory activity to COX-2 reaction, and especially luteolin, kaempferol, hesperetin, and naringin showed relatively the potent inhibition on COX-2 reaction.	Flavonoids	22-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-75
21535545-6	2010	Otherwise, all tested flavonoids possessed the inhibitory activity to COX-2 reaction, and especially luteolin, kaempferol, hesperetin, and naringin showed relatively the potent inhibition on COX-2 reaction.	Flavonoids	22-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	191-196
21535545-6	2010	Otherwise, all tested flavonoids possessed the inhibitory activity to COX-2 reaction, and especially luteolin, kaempferol, hesperetin, and naringin showed relatively the potent inhibition on COX-2 reaction.	Luteolin	101-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	191-196
21535545-6	2010	Otherwise, all tested flavonoids possessed the inhibitory activity to COX-2 reaction, and especially luteolin, kaempferol, hesperetin, and naringin showed relatively the potent inhibition on COX-2 reaction.	kaempferol	111-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	191-196
21535545-6	2010	Otherwise, all tested flavonoids possessed the inhibitory activity to COX-2 reaction, and especially luteolin, kaempferol, hesperetin, and naringin showed relatively the potent inhibition on COX-2 reaction.	hesperetin	123-133	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	191-196
21535545-6	2010	Otherwise, all tested flavonoids possessed the inhibitory activity to COX-2 reaction, and especially luteolin, kaempferol, hesperetin, and naringin showed relatively the potent inhibition on COX-2 reaction.	naringin	139-147	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-75
21535545-6	2010	Otherwise, all tested flavonoids possessed the inhibitory activity to COX-2 reaction, and especially luteolin, kaempferol, hesperetin, and naringin showed relatively the potent inhibition on COX-2 reaction.	naringin	139-147	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	191-196
21036716-2	2010	The aim of this study was to investigate the effects of the COX2 inhibitor celecoxib and the mTOR antagonist rapamycin on angiosarcoma cell lines.	Celecoxib	75-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-64
20691240-0	2010	The dietary flavonoid apigenin blocks phorbol 12-myristate 13-acetate-induced COX-2 transcriptional activity in breast cell lines.	Flavonoids	12-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-83
20691240-0	2010	The dietary flavonoid apigenin blocks phorbol 12-myristate 13-acetate-induced COX-2 transcriptional activity in breast cell lines.	Apigenin	22-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-83
20709632-3	2010	Here, we have analyzed the effects on T cell activation of novel 4,5-dihydro-3 trifluoromethyl pyrazole anti-inflammatory drugs with different potencies as COX-2 inhibitors, namely E-6087, E-6232, E-6231, E-6036 and E-6259 as well as the chemically related COX-2 inhibitor Celecoxib.	4,5-dihydro-3 trifluoromethyl pyrazole	65-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	156-161
20840388-2	2010	Whole blood assays were used to characterize in the cat the pharmacodynamics of robenacoxib for inhibition of the cyclooxygenase (COX) isoforms, COX-1 and COX-2, in comparison with other NSAIDs.	robenacoxib	80-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	155-160
20840388-3	2010	Based on in vitro IC(50) COX-1:IC(50) COX-2 ratios, robenacoxib was COX-2 selective (ratio = 32.2), diclofenac (ratio = 3.9) and meloxicam (ratio = 2.7) were only weakly COX-2 preferential, and ketoprofen (ratio = 0.049) was COX-1 selective.	robenacoxib	52-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-43
20840388-3	2010	Based on in vitro IC(50) COX-1:IC(50) COX-2 ratios, robenacoxib was COX-2 selective (ratio = 32.2), diclofenac (ratio = 3.9) and meloxicam (ratio = 2.7) were only weakly COX-2 preferential, and ketoprofen (ratio = 0.049) was COX-1 selective.	robenacoxib	52-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-73
20840388-3	2010	Based on in vitro IC(50) COX-1:IC(50) COX-2 ratios, robenacoxib was COX-2 selective (ratio = 32.2), diclofenac (ratio = 3.9) and meloxicam (ratio = 2.7) were only weakly COX-2 preferential, and ketoprofen (ratio = 0.049) was COX-1 selective.	robenacoxib	52-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-73
20954326-1	2010	Prostaglandin E2 (PGE2) is a proinflammatory mediator that is synthesized by cyclooxygenases (COX-1 and COX-2) and prostaglandin E synthases (cPGES-1 and mPGES-1); PGE2 exerts its biological effects by binding to specific receptors.	Dinoprostone	0-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
20954326-1	2010	Prostaglandin E2 (PGE2) is a proinflammatory mediator that is synthesized by cyclooxygenases (COX-1 and COX-2) and prostaglandin E synthases (cPGES-1 and mPGES-1); PGE2 exerts its biological effects by binding to specific receptors.	Dinoprostone	18-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
21174772-7	2010	TSSN treatment significantly attenuated mRNA of inflammatory mediators such as COX-2, IL-1beta, IL-6 while increased PPAR-gamma gene and protein expression.	tssn	0-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-84
21587471-2	2010	The Co(II) cation is in a distorted octa-hedral environment, coordinated by four sulfonate O atoms and two N atoms from the taurine ligands.	sulfonate	81-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
21587471-2	2010	The Co(II) cation is in a distorted octa-hedral environment, coordinated by four sulfonate O atoms and two N atoms from the taurine ligands.	Nitrogen	107-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
21587471-2	2010	The Co(II) cation is in a distorted octa-hedral environment, coordinated by four sulfonate O atoms and two N atoms from the taurine ligands.	Taurine	124-131	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
21587471-4	2010	The sulfonate groups doubly bridge symmetry-related Co(II) atoms, forming polymeric chains along the a axis.	sulfonate	4-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-58
20804197-3	2010	Molecular modeling studies showed that the methylsulfone group of these compounds was inserted deep in the pocket of the human COX-2 binding site, in an orientation that precludes hydrogen bonding with Arg120, Ser353, and Tyr355 through their oxygen atoms.	dimethyl sulfone	43-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	127-132
20804197-3	2010	Molecular modeling studies showed that the methylsulfone group of these compounds was inserted deep in the pocket of the human COX-2 binding site, in an orientation that precludes hydrogen bonding with Arg120, Ser353, and Tyr355 through their oxygen atoms.	Hydrogen	180-188	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	127-132
20804197-3	2010	Molecular modeling studies showed that the methylsulfone group of these compounds was inserted deep in the pocket of the human COX-2 binding site, in an orientation that precludes hydrogen bonding with Arg120, Ser353, and Tyr355 through their oxygen atoms.	Oxygen	243-249	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	127-132
20804197-4	2010	The N-arylindole 33 was the most potent inhibitor of COX-2 and also the most selective (COX-1/COX-2 IC(50) ratio was 262).	n-arylindole	4-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-58
20804197-4	2010	The N-arylindole 33 was the most potent inhibitor of COX-2 and also the most selective (COX-1/COX-2 IC(50) ratio was 262).	n-arylindole	4-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-99
20735129-3	2010	The Co(II)-based catalytic system can be operated in a one-time protocol under mild conditions, affording the desired cyclopropane products in high yields with both high diastereo- and enantioselectivity.	cyclopropane	118-139	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
20664853-3	2010	Although this new group of 1,1-diaryl-2-(4-hydroxyaminosulfonylphenyl)alk-1-enes exhibited weak inhibition of the constitutive cyclooxygenase-1 (COX-1) and inducible COX-2 isozymes, in vivo studies showed anti-inflammatory potencies that were generally intermediate between that of the reference drugs aspirin and ibuprofen.	1,1-diaryl-2-(4-hydroxyaminosulfonylphenyl)alk-1-enes	27-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	166-171
20722379-2	2010	Furthermore, crystal structures of the parent porphyrins, M(TPP)(Ph)(4) (M = Co(II), Cu(II)) complexes, were also determined.	tetraphenylporphine sulfonate	60-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-83
20722379-5	2010	Crystal structures of the parent M(TPP)(Ph)(4) (M = Co(II), Cu(II)) complexes indicated near planarity of the 24-atom core with the root-mean-square deviation value of 0.016(2) A. Molecular packing in the M(TPP)(Ph)(4) C(60) cocrystals showed essentially one-dimensional chains interconnected by weak interporphyrin and porphyrin-fullerene close contacts.	tetraphenylporphine sulfonate	35-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-58
20722379-6	2010	The N(porphyrin)   C(C(60)) shortest distances between the H(2)(TPP)(Ph)(4) (M = 2H, Co(II), Cu(II)) and fullerene in the cocrystals are 3.031(5) A, 3.062(4) A, and 3.059(3) A, respectively.	tetraphenylporphine sulfonate	64-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-91
20722379-6	2010	The N(porphyrin)   C(C(60)) shortest distances between the H(2)(TPP)(Ph)(4) (M = 2H, Co(II), Cu(II)) and fullerene in the cocrystals are 3.031(5) A, 3.062(4) A, and 3.059(3) A, respectively.	Fullerenes	105-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-91
20722379-7	2010	Similarly, close contact M   C distances in the M(TPP)(Ph)(4) C(60) (M = Co(II), Cu(II)) are 2.761(6) A and 2.886(3) A, respectively.	tetraphenylporphine sulfonate	50-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-79
20657942-0	2010	First report on N,N"-diisoalkylisonicotinamide 1D coordination network containing linear trinuclear [Co3L4Cl6] units with mixed Co(II)(Td)-Co(II)(Oh)-Co(II)(Td) geometries: structure and magnetic properties.	n,n"-diisoalkylisonicotinamide	16-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	128-134
20657942-0	2010	First report on N,N"-diisoalkylisonicotinamide 1D coordination network containing linear trinuclear [Co3L4Cl6] units with mixed Co(II)(Td)-Co(II)(Oh)-Co(II)(Td) geometries: structure and magnetic properties.	n,n"-diisoalkylisonicotinamide	16-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-145
20657942-0	2010	First report on N,N"-diisoalkylisonicotinamide 1D coordination network containing linear trinuclear [Co3L4Cl6] units with mixed Co(II)(Td)-Co(II)(Oh)-Co(II)(Td) geometries: structure and magnetic properties.	n,n"-diisoalkylisonicotinamide	16-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-145
20657942-2	2010	The central Co(II) ion, of each trinuclear entity, exhibits a distorted octahedral geometry, with two ligand molecules coordinating through their carbonyl oxygen atoms along with two bridging Cl(-) ions and two pyridine N atoms from the neighboring molecules.	Oxygen	155-161	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-18
20657942-2	2010	The central Co(II) ion, of each trinuclear entity, exhibits a distorted octahedral geometry, with two ligand molecules coordinating through their carbonyl oxygen atoms along with two bridging Cl(-) ions and two pyridine N atoms from the neighboring molecules.	pyridine n	211-221	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-18
20657942-3	2010	Also, in each unit, two outer Co(II) ions display distorted tetrahedral geometry, coordinating to one ligand molecule through the pyridine N atom and to three Cl(-) ions (one of them bridged to the central Co(II) and the two acting as a terminal ligands).	pyridine n	130-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-36
20657942-8	2010	As a result, the analysis of the magnetic data shows that, within every trinuclear unit, the central position matches well with a high-spin Co(II) (S = 3/2) and also reveals weak ferromagnetic interactions between the Co(O(h)) and the two terminal Co(T(d)) ions (J = +0.34 cm(-1)).	co(o(h))	218-226	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-146
21587377-1	2010	In the polymeric title compound, [Co(2)(C(3)H(7)NO)(3)(C(8)H(3)NO(6))(2)] C(3)H(7)NO, one 5-nitro-isophthalate dianion has its two carboxyl-ate groups chelating to one Co(II) atom while simultaneously coordinating to another metal atom in a mu(4)-bridging mode.	co(2)	34-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	168-174
21587377-1	2010	In the polymeric title compound, [Co(2)(C(3)H(7)NO)(3)(C(8)H(3)NO(6))(2)] C(3)H(7)NO, one 5-nitro-isophthalate dianion has its two carboxyl-ate groups chelating to one Co(II) atom while simultaneously coordinating to another metal atom in a mu(4)-bridging mode.	Carbon	34-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	168-174
20657935-0	2010	Click on silica: systematic immobilization of Co(II) Schiff bases to the mesoporous silica via click reaction and their catalytic activity for aerobic oxidation of alcohols.	Silicon Dioxide	84-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
20657935-0	2010	Click on silica: systematic immobilization of Co(II) Schiff bases to the mesoporous silica via click reaction and their catalytic activity for aerobic oxidation of alcohols.	Alcohols	164-172	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
20657935-1	2010	The systematic immobilization of cobalt(II) Schiff base complexes on SBA-15 mesoporous silica via copper catalyzed [3 + 2] azide-alkyne cycloaddition (CuAAC) "click reaction" involving either step-wise synthesis of silica-bound Schiff base ligand followed by its subsequent complexation with cobalt ions, or by the direct immobilization of preformed Co(II) Schiff base complex to the silica support is described.	cobalt(ii) schiff base	33-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	350-355
20657935-1	2010	The systematic immobilization of cobalt(II) Schiff base complexes on SBA-15 mesoporous silica via copper catalyzed [3 + 2] azide-alkyne cycloaddition (CuAAC) "click reaction" involving either step-wise synthesis of silica-bound Schiff base ligand followed by its subsequent complexation with cobalt ions, or by the direct immobilization of preformed Co(II) Schiff base complex to the silica support is described.	Silicon Dioxide	87-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	350-355
20657935-1	2010	The systematic immobilization of cobalt(II) Schiff base complexes on SBA-15 mesoporous silica via copper catalyzed [3 + 2] azide-alkyne cycloaddition (CuAAC) "click reaction" involving either step-wise synthesis of silica-bound Schiff base ligand followed by its subsequent complexation with cobalt ions, or by the direct immobilization of preformed Co(II) Schiff base complex to the silica support is described.	Copper	98-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	350-355
20657935-1	2010	The systematic immobilization of cobalt(II) Schiff base complexes on SBA-15 mesoporous silica via copper catalyzed [3 + 2] azide-alkyne cycloaddition (CuAAC) "click reaction" involving either step-wise synthesis of silica-bound Schiff base ligand followed by its subsequent complexation with cobalt ions, or by the direct immobilization of preformed Co(II) Schiff base complex to the silica support is described.	Schiff Bases	44-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	350-355
20657935-1	2010	The systematic immobilization of cobalt(II) Schiff base complexes on SBA-15 mesoporous silica via copper catalyzed [3 + 2] azide-alkyne cycloaddition (CuAAC) "click reaction" involving either step-wise synthesis of silica-bound Schiff base ligand followed by its subsequent complexation with cobalt ions, or by the direct immobilization of preformed Co(II) Schiff base complex to the silica support is described.	Cobalt	33-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	350-355
20431935-6	2010	The protective effect of the mutant allele of the COX-2 polymorphism was more pronounced among subjects with high plasma levels of beta-cryptoxanthin, lycopene, beta-carotene, or selenium (&gt;or=median) [e.g., OR (95% CI): 0.37 (0.15, 0.86) (AG/GG vs. AA) for beta-cryptoxanthin].	Beta-Cryptoxanthin	131-149	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-55
20431935-6	2010	The protective effect of the mutant allele of the COX-2 polymorphism was more pronounced among subjects with high plasma levels of beta-cryptoxanthin, lycopene, beta-carotene, or selenium (&gt;or=median) [e.g., OR (95% CI): 0.37 (0.15, 0.86) (AG/GG vs. AA) for beta-cryptoxanthin].	Lycopene	151-159	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-55
20431935-6	2010	The protective effect of the mutant allele of the COX-2 polymorphism was more pronounced among subjects with high plasma levels of beta-cryptoxanthin, lycopene, beta-carotene, or selenium (&gt;or=median) [e.g., OR (95% CI): 0.37 (0.15, 0.86) (AG/GG vs. AA) for beta-cryptoxanthin].	beta Carotene	161-174	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-55
20431935-6	2010	The protective effect of the mutant allele of the COX-2 polymorphism was more pronounced among subjects with high plasma levels of beta-cryptoxanthin, lycopene, beta-carotene, or selenium (&gt;or=median) [e.g., OR (95% CI): 0.37 (0.15, 0.86) (AG/GG vs. AA) for beta-cryptoxanthin].	Selenium	179-187	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-55
20431935-6	2010	The protective effect of the mutant allele of the COX-2 polymorphism was more pronounced among subjects with high plasma levels of beta-cryptoxanthin, lycopene, beta-carotene, or selenium (&gt;or=median) [e.g., OR (95% CI): 0.37 (0.15, 0.86) (AG/GG vs. AA) for beta-cryptoxanthin].	Beta-Cryptoxanthin	261-279	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-55
20496179-2	2010	This study was designed to investigate whether celecoxib, a selective COX-2 inhibitor, has effects on retinoid sensitivity in human colon cancer cell lines, and to determine the possible mechanism of said effects.	Celecoxib	47-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-75
20496179-7	2010	The results showed that celecoxib enhanced the inhibitory effect of ATRA in both COX-2 high-expressing HT-29 and COX-2 low-expressing SW480 cell lines.	Celecoxib	24-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-86
20496179-7	2010	The results showed that celecoxib enhanced the inhibitory effect of ATRA in both COX-2 high-expressing HT-29 and COX-2 low-expressing SW480 cell lines.	Celecoxib	24-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-118
20496179-7	2010	The results showed that celecoxib enhanced the inhibitory effect of ATRA in both COX-2 high-expressing HT-29 and COX-2 low-expressing SW480 cell lines.	Tretinoin	68-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-86
20496179-7	2010	The results showed that celecoxib enhanced the inhibitory effect of ATRA in both COX-2 high-expressing HT-29 and COX-2 low-expressing SW480 cell lines.	Tretinoin	68-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-118
20496179-11	2010	In conclusion, celecoxib increased the expression of RARbeta and the level of cellular ATRA sensitivity through COX-2-independent mechanisms.	Celecoxib	15-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-117
20496179-11	2010	In conclusion, celecoxib increased the expression of RARbeta and the level of cellular ATRA sensitivity through COX-2-independent mechanisms.	Tretinoin	87-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-117
20047843-5	2010	In non-small cell lung cancer (NSCLC), the strongest clinical evidence is for taxane resistance with elevated expression or mutation of class III beta-tubulin (and possibly alpha tubulin), platinum resistance and expression of ERCC1 or BCRP, gemcitabine resistance and RRM1 expression, and resistance to several agents and COX-2 expression (although COX-2 inhibitors have had minimal impact on drug efficacy clinically).	taxane	78-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	323-328
20047843-5	2010	In non-small cell lung cancer (NSCLC), the strongest clinical evidence is for taxane resistance with elevated expression or mutation of class III beta-tubulin (and possibly alpha tubulin), platinum resistance and expression of ERCC1 or BCRP, gemcitabine resistance and RRM1 expression, and resistance to several agents and COX-2 expression (although COX-2 inhibitors have had minimal impact on drug efficacy clinically).	taxane	78-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	350-355
20812134-4	2010	ROC acts as a potent inhibitor of iNOS and COX-2 gene expression while also suppressing the production of PGE(2) and nitrite in human chondrocytes.	Saquinavir	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
20812134-6	2010	These findings suggest that ROC exerts anti-inflammatory effects probably through the suppression of COX-2 and iNOS expression.	Saquinavir	28-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-106
20558741-0	2010	Sphingosine interaction with acidic leucine-rich nuclear phosphoprotein-32A (ANP32A) regulates PP2A activity and cyclooxygenase (COX)-2 expression in human endothelial cells.	Sphingosine	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-135
20600219-10	2010	The protein kinase inhibitors had minimal or no effects on Ni/MALP-2-induced accumulation of HIF-1alpha protein, however, COX-2 expression and, more markedly PGE(2) production, were suppressed by LY294002, SB203580, and U0126.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	196-204	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-127
20600219-10	2010	The protein kinase inhibitors had minimal or no effects on Ni/MALP-2-induced accumulation of HIF-1alpha protein, however, COX-2 expression and, more markedly PGE(2) production, were suppressed by LY294002, SB203580, and U0126.	SB 203580	206-214	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-127
21588541-1	2010	In the title mononuclear cobalt(III) compound, [Co(C(9)H(8)ClNO(2))(C(9)H(9)ClNO(2))], the Co(II) atom is six-coordinated by two imine N atoms, two phenolate O atoms, and one hy-droxy and one oxide O atom from two Schiff base ligands, forming an octa-hedral geometry.	cobalt(iii)	25-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-97
20731837-8	2010	Suppression of COX-2 in A549 cells induced multinucleated cells and caused radiosensitization after gefitinib+IR treatment.	Gefitinib	100-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-20
20731837-10	2010	CONCLUSIONS: Our results suggest that gefitinib radiosensitizes NSCLC cells by inhibiting ATM activity and therefore inducing mitotic cell death, and that COX-2 overexpression in NSCLC cells inhibits this action of gefitinib.	Gefitinib	215-224	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	155-160
21588541-1	2010	In the title mononuclear cobalt(III) compound, [Co(C(9)H(8)ClNO(2))(C(9)H(9)ClNO(2))], the Co(II) atom is six-coordinated by two imine N atoms, two phenolate O atoms, and one hy-droxy and one oxide O atom from two Schiff base ligands, forming an octa-hedral geometry.	co(c(9)h	48-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-97
21588541-1	2010	In the title mononuclear cobalt(III) compound, [Co(C(9)H(8)ClNO(2))(C(9)H(9)ClNO(2))], the Co(II) atom is six-coordinated by two imine N atoms, two phenolate O atoms, and one hy-droxy and one oxide O atom from two Schiff base ligands, forming an octa-hedral geometry.	)clno	58-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-97
21588541-1	2010	In the title mononuclear cobalt(III) compound, [Co(C(9)H(8)ClNO(2))(C(9)H(9)ClNO(2))], the Co(II) atom is six-coordinated by two imine N atoms, two phenolate O atoms, and one hy-droxy and one oxide O atom from two Schiff base ligands, forming an octa-hedral geometry.	Carbon	48-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-97
21588541-1	2010	In the title mononuclear cobalt(III) compound, [Co(C(9)H(8)ClNO(2))(C(9)H(9)ClNO(2))], the Co(II) atom is six-coordinated by two imine N atoms, two phenolate O atoms, and one hy-droxy and one oxide O atom from two Schiff base ligands, forming an octa-hedral geometry.	clno	59-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-97
21588541-1	2010	In the title mononuclear cobalt(III) compound, [Co(C(9)H(8)ClNO(2))(C(9)H(9)ClNO(2))], the Co(II) atom is six-coordinated by two imine N atoms, two phenolate O atoms, and one hy-droxy and one oxide O atom from two Schiff base ligands, forming an octa-hedral geometry.	imine n	129-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-97
21588541-1	2010	In the title mononuclear cobalt(III) compound, [Co(C(9)H(8)ClNO(2))(C(9)H(9)ClNO(2))], the Co(II) atom is six-coordinated by two imine N atoms, two phenolate O atoms, and one hy-droxy and one oxide O atom from two Schiff base ligands, forming an octa-hedral geometry.	oxide o	192-199	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-97
21588541-1	2010	In the title mononuclear cobalt(III) compound, [Co(C(9)H(8)ClNO(2))(C(9)H(9)ClNO(2))], the Co(II) atom is six-coordinated by two imine N atoms, two phenolate O atoms, and one hy-droxy and one oxide O atom from two Schiff base ligands, forming an octa-hedral geometry.	Schiff Bases	214-225	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-97
21588541-1	2010	In the title mononuclear cobalt(III) compound, [Co(C(9)H(8)ClNO(2))(C(9)H(9)ClNO(2))], the Co(II) atom is six-coordinated by two imine N atoms, two phenolate O atoms, and one hy-droxy and one oxide O atom from two Schiff base ligands, forming an octa-hedral geometry.	hedral	251-257	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-97
21588529-2	2010	The Co(II) atom (site symmetry 2) is six-coordinate in a distorted octahedral configuration bonded by two N and two O atoms from two (2-amino-phen-yl)methanol ligands and two O atoms from the two nitrate anions.	Nitrogen	106-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
21373319-9	2010	Non-steroidal analgesics and other COX-2 inhibitors (rofecoxib and celecoxib) have been known to precipitate renal failure and hyperkalemia specially in patients at risk for the same; although not unexpected, this may be the first reported case of life-threatening hyperkalemia precipitated by etoricoxib in a previously stable patient having increased risk of renal failure and hyperkalemia.	rofecoxib	53-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40
21373319-9	2010	Non-steroidal analgesics and other COX-2 inhibitors (rofecoxib and celecoxib) have been known to precipitate renal failure and hyperkalemia specially in patients at risk for the same; although not unexpected, this may be the first reported case of life-threatening hyperkalemia precipitated by etoricoxib in a previously stable patient having increased risk of renal failure and hyperkalemia.	Celecoxib	67-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40
21373319-9	2010	Non-steroidal analgesics and other COX-2 inhibitors (rofecoxib and celecoxib) have been known to precipitate renal failure and hyperkalemia specially in patients at risk for the same; although not unexpected, this may be the first reported case of life-threatening hyperkalemia precipitated by etoricoxib in a previously stable patient having increased risk of renal failure and hyperkalemia.	Etoricoxib	294-304	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40
21588529-2	2010	The Co(II) atom (site symmetry 2) is six-coordinate in a distorted octahedral configuration bonded by two N and two O atoms from two (2-amino-phen-yl)methanol ligands and two O atoms from the two nitrate anions.	2-aminobenzyl alcohol	133-158	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
21588529-2	2010	The Co(II) atom (site symmetry 2) is six-coordinate in a distorted octahedral configuration bonded by two N and two O atoms from two (2-amino-phen-yl)methanol ligands and two O atoms from the two nitrate anions.	Nitrates	196-203	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
20690752-0	2010	Para-quinone-containing bis(pyrazol-1-yl)methane ligands: coordination behavior toward Co(II) and a C-H activation reaction with Ce(IV).	quinone	0-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-93
20696045-0	2010	Role of COX-2 in cough reflex sensitivity to inhaled capsaicin in patients with sinobronchial syndrome.	Capsaicin	53-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	8-13
20690752-0	2010	Para-quinone-containing bis(pyrazol-1-yl)methane ligands: coordination behavior toward Co(II) and a C-H activation reaction with Ce(IV).	1-(1H-Pyrazol-1-ylmethyl)-1H-pyrazole	24-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-93
20690752-2	2010	In the solid state, already the sterically least encumbered derivative L2(Me2) is able to stabilize Co(II) complexes of the form [X(2)Co(L2(Me2))] (X = Cl, NO(3)); in solution, these complexes are at an equilibrium with the 1:2 species [Co(L2(Me2))(2)](2+).	Threonine	71-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-106
20690752-2	2010	In the solid state, already the sterically least encumbered derivative L2(Me2) is able to stabilize Co(II) complexes of the form [X(2)Co(L2(Me2))] (X = Cl, NO(3)); in solution, these complexes are at an equilibrium with the 1:2 species [Co(L2(Me2))(2)](2+).	co(l2(	134-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-106
20567791-2	2010	The bis-gamma-pyrone forms stable metal complexes with Li, Mg, Cu(II), Ni(II), Zn, Fe(II), Co(II) and Ba perchlorates whose crystal structures reveal that the ligand possesses significant bispyrylium character while the metal is coordinated at the negatively charged edge of the structure.	bis-gamma-pyrone	4-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-97
20567791-2	2010	The bis-gamma-pyrone forms stable metal complexes with Li, Mg, Cu(II), Ni(II), Zn, Fe(II), Co(II) and Ba perchlorates whose crystal structures reveal that the ligand possesses significant bispyrylium character while the metal is coordinated at the negatively charged edge of the structure.	Metals	34-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-97
20696045-5	2010	METHODS: The effect of etodolac, a potent COX-2 inhibitor, on cough response to inhaled capsaicin was examined in 15 patients with sinobronchial syndrome in a randomized, placebo-controlled cross-over study.	Etodolac	23-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47
20691059-7	2010	Further evidence is presented that synoviocyte responses to ROS and TRPV1 activation include increases in TNFalpha and COX-2, both measured as an indicator of the inflammation in vitro.	ros	60-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-124
20237495-3	2010	The NSAID diclofenac is an inhibitor of COX-2; however, its mode of action in cutaneous epithelial cancer cells is largely unknown.	Diclofenac	10-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
20576432-5	2010	These studies indicate that use of a cupferron template constitutes a plausible drug design approach targeted toward the development of AI drugs that do not cause gastric irritation, or elevate blood pressure and induce platelet aggregation that have been associated with the use of some selective COX-2 inhibitors.	cupferron	37-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	298-303
20712078-3	2010	In this study, we report that the expression of microRNA-101 (miR-101) is down-regulated in gastric cancer tissues and cells, and ectopic expression of miR-101 significantly inhibits cellular proliferation, migration and invasion of gastric cancer cells by targeting EZH2, Cox-2, Mcl-1 and Fos.	mir-101	62-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	273-278
20505677-4	2010	We found that losartan significantly attenuated the LPS-induced expression of proinflammatory genes TNF-alpha, IL-8 and COX-2.	Losartan	14-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-125
20186739-2	2010	Previous studies revealed that Cr(III) and Co(II) ions could induce damages to proteins in macrophage-like cells in vitro, probably through the formation of reactive oxygen species (ROS).	Reactive Oxygen Species	157-180	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-49
20186739-2	2010	Previous studies revealed that Cr(III) and Co(II) ions could induce damages to proteins in macrophage-like cells in vitro, probably through the formation of reactive oxygen species (ROS).	Reactive Oxygen Species	182-185	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-49
20186739-7	2010	In conclusion, results showed that Cr(VI), Cr(III), and Co(II) had differential effects on the expression of antioxidant enzymes in macrophage-like cells in vitro.	Chromium	35-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-62
20689756-5	2010	EPA-FFA in cell culture medium was incorporated rapidly into phospholipid membranes of HCA-7 human CRC cells and acted as a substrate for COX-2, leading to reduced synthesis of PGE(2) and generation of PGE(3).	Prostaglandins E	177-180	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	138-143
20662025-0	2010	Effect of Ga-Al-As laser irradiation on COX-2 and cPLA2-alpha expression in compressed human periodontal ligament cells.	ga-al	10-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
20662025-9	2010	CONCLUSIONS: The inhibition of PGE(2) production by LLL irradiation in compressed PDL cells may be due to the inhibition of COX-2 and cPLA(2)-alpha expression and is most pronounced immediately after the application of a compressive force.	Prostaglandins E	31-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	124-129
21030939-3	2010	Nimesulide is the only NSAID related to the arylsulfonamide class and is a "COX-2 preferential NSAIDs", because despite having a prevalent effect on COX-2, has a balanced action on both cyclooxygenase.	nimesulide	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-81
21030939-3	2010	Nimesulide is the only NSAID related to the arylsulfonamide class and is a "COX-2 preferential NSAIDs", because despite having a prevalent effect on COX-2, has a balanced action on both cyclooxygenase.	nimesulide	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	149-154
21030939-6	2010	From the standpoint of safety, nimesulide arises NSAIDs with lower risk of upper gastrointestinal bleeding thanks to its preferential activity on COX-2.	nimesulide	31-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	146-151
20426797-11	2010	Ursodeoxycholic acid decreases macrophages, degranulated mast cells and COX-2 expression.	Ursodeoxycholic Acid	0-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
20689756-5	2010	EPA-FFA in cell culture medium was incorporated rapidly into phospholipid membranes of HCA-7 human CRC cells and acted as a substrate for COX-2, leading to reduced synthesis of PGE(2) and generation of PGE(3).	Prostaglandins E	202-205	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	138-143
20689756-8	2010	We conclude that EPA-FFA drives a COX-2-dependent "PGE(2)-to-PGE(3) switch" in human CRC cells and that PGE(3) acts as a partial agonist at the PGE(2) EP4 receptor.	epa-ffa	17-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-39
20689756-8	2010	We conclude that EPA-FFA drives a COX-2-dependent "PGE(2)-to-PGE(3) switch" in human CRC cells and that PGE(3) acts as a partial agonist at the PGE(2) EP4 receptor.	Prostaglandins E	51-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-39
20689756-8	2010	We conclude that EPA-FFA drives a COX-2-dependent "PGE(2)-to-PGE(3) switch" in human CRC cells and that PGE(3) acts as a partial agonist at the PGE(2) EP4 receptor.	Prostaglandins E	61-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-39
20689756-8	2010	We conclude that EPA-FFA drives a COX-2-dependent "PGE(2)-to-PGE(3) switch" in human CRC cells and that PGE(3) acts as a partial agonist at the PGE(2) EP4 receptor.	Prostaglandins E	61-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-39
20689756-8	2010	We conclude that EPA-FFA drives a COX-2-dependent "PGE(2)-to-PGE(3) switch" in human CRC cells and that PGE(3) acts as a partial agonist at the PGE(2) EP4 receptor.	Prostaglandins E	61-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-39
19908231-7	2010	Resveratrol inhibited the proliferation of 4 different human PaCa cell lines, synergized the apoptotic effects of gemcitabine, inhibited the constitutive activation of NF-kappaB and expression of bcl-2, bcl-xL, COX-2, cyclin D1 MMP-9 and VEGF.	Resveratrol	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	211-216
21588110-1	2010	In the title complex, [Co(C(22)H(15)O(5))(2)(C(2)H(5)OH)(2)], the Co(II) atom (site symmetry ) is coordinated by two O,O"-bidentate 4-(2-benzoyl-1-oxidoethen-yl)-3-hy-droxy-phenyl benzoate anions and two ethanol O atoms, resulting in a slightly distorted CoO(6) octa-hedral coordination.	Cobalt	23-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-72
21588110-1	2010	In the title complex, [Co(C(22)H(15)O(5))(2)(C(2)H(5)OH)(2)], the Co(II) atom (site symmetry ) is coordinated by two O,O"-bidentate 4-(2-benzoyl-1-oxidoethen-yl)-3-hy-droxy-phenyl benzoate anions and two ethanol O atoms, resulting in a slightly distorted CoO(6) octa-hedral coordination.	Carbon	23-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-72
21588110-1	2010	In the title complex, [Co(C(22)H(15)O(5))(2)(C(2)H(5)OH)(2)], the Co(II) atom (site symmetry ) is coordinated by two O,O"-bidentate 4-(2-benzoyl-1-oxidoethen-yl)-3-hy-droxy-phenyl benzoate anions and two ethanol O atoms, resulting in a slightly distorted CoO(6) octa-hedral coordination.	o,o"-bidentate 4-(2-benzoyl-1-oxidoethen-yl)-3-hy-droxy-phenyl benzoate	117-188	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-72
21588110-1	2010	In the title complex, [Co(C(22)H(15)O(5))(2)(C(2)H(5)OH)(2)], the Co(II) atom (site symmetry ) is coordinated by two O,O"-bidentate 4-(2-benzoyl-1-oxidoethen-yl)-3-hy-droxy-phenyl benzoate anions and two ethanol O atoms, resulting in a slightly distorted CoO(6) octa-hedral coordination.	Ethanol	204-211	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-72
20580659-6	2010	S.c. treatment with the preferential COX-2 inhibitor meloxicam attenuated, but not abolished fever induced by local injections of MALP-2 into the pouch.	Meloxicam	53-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-42
20532261-1	2010	Two new Co(ii)-Cr(iii) phosphonate clusters with [Co(II)(4)Cr(III)(4)] and [Co(II)(8)Cr(III)(4)] cores have been synthesized by a displacement reaction from a pre-formed heterometallic carboxylate cage.	tris(1,10-phenanthroline)chromium(III) chloride	59-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	8-13
20532261-1	2010	Two new Co(ii)-Cr(iii) phosphonate clusters with [Co(II)(4)Cr(III)(4)] and [Co(II)(8)Cr(III)(4)] cores have been synthesized by a displacement reaction from a pre-formed heterometallic carboxylate cage.	carboxylate	185-196	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	8-13
19908231-10	2010	As compared to vehicle control, resveratrol also suppressed the NF-kappaB activation and expression of cyclin D1, COX-2, ICAM-1, MMP-9 and survivin.	Resveratrol	32-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-119
20451580-3	2010	Here, we used transgenic mice, which overexpressed human COX-2 via neuron-specific Thy-1 promoter (TgCOX-2), causing elevated prostaglandins (PGs) levels.	Prostaglandins	126-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-62
20451580-3	2010	Here, we used transgenic mice, which overexpressed human COX-2 via neuron-specific Thy-1 promoter (TgCOX-2), causing elevated prostaglandins (PGs) levels.	Prostaglandins	142-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-62
20505855-0	2010	Synthesis and characterisation of Mn(II), Co(II) and Cd(II) coordination polymers of 1,2,4-triazole-3, 5-dicarboxylic acid.	1,2,4-triazole-3, 5-dicarboxylic acid	85-122	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-48
20527891-2	2010	Two metabolites showed activity in these assays; the 3-sulfate exhibited QR1 induction, DPPH free radical scavenging, and COX-1 and COX-2 inhibitory activities and the 4"-sulfate inhibited NFkappaB induction, as well as COX-1 and COX-2 activities.	3-sulfate	53-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-137
20527891-2	2010	Two metabolites showed activity in these assays; the 3-sulfate exhibited QR1 induction, DPPH free radical scavenging, and COX-1 and COX-2 inhibitory activities and the 4"-sulfate inhibited NFkappaB induction, as well as COX-1 and COX-2 activities.	3-sulfate	53-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	230-235
20540554-4	2010	Computational studies, in combination with experimental results, establish that the triplet spin isomer arises from a high spin Co(II) center (S(Co) = 3/2) antiferromagnetically coupled to a bis(imino)pyridine chelate radical anion, [PDI](-) (S(PDI) = 1/2).	bis(imino)pyridine	191-209	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	128-134
20540554-5	2010	At lower temperatures, the Co(II) ion undergoes a spin transition to the low spin form (S(Co) = 1/2) and antiferromagnetic coupling gives rise to the observed diamagnetic ground state.	Cobalt	90-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-33
20462589-0	2010	Cyclam complexes of Cu(II) and Co(II) as stationary phases for gas chromatography.	cyclam	0-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-37
20462589-2	2010	The complexes of 1,4,8,11-tetraazacyclotetradecane with Cu(II) and Co(II) were bonded to the silica support through the (3-chloropropyl)triethoxysilane reactant.	cyclam	17-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-73
20462589-2	2010	The complexes of 1,4,8,11-tetraazacyclotetradecane with Cu(II) and Co(II) were bonded to the silica support through the (3-chloropropyl)triethoxysilane reactant.	Silicon Dioxide	93-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-73
20462589-2	2010	The complexes of 1,4,8,11-tetraazacyclotetradecane with Cu(II) and Co(II) were bonded to the silica support through the (3-chloropropyl)triethoxysilane reactant.	(3-Chloropropyl)triethoxysilane	120-151	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-73
20691338-2	2010	In vitro COX-1/COX-2 structure-activity relationships were determined by varying the substituents on the C-3 propenone moiety.	propenone	109-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-20
20691338-3	2010	Among the 1,2,3-triaryl-2-propen-1-ones, (Z)-1-(4-(methylsulfonyl)phenyl)-2,3-diphenylprop-2-en-1-one (3b) showed the most potency and selectivity on COX-2 inhibition (COX-2 IC(50) = 0.07 microM; selectivity index = 201).	1,2,3-triaryl-2-propen-1-ones	10-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	150-155
20691338-3	2010	Among the 1,2,3-triaryl-2-propen-1-ones, (Z)-1-(4-(methylsulfonyl)phenyl)-2,3-diphenylprop-2-en-1-one (3b) showed the most potency and selectivity on COX-2 inhibition (COX-2 IC(50) = 0.07 microM; selectivity index = 201).	1,2,3-triaryl-2-propen-1-ones	10-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	168-173
20691338-3	2010	Among the 1,2,3-triaryl-2-propen-1-ones, (Z)-1-(4-(methylsulfonyl)phenyl)-2,3-diphenylprop-2-en-1-one (3b) showed the most potency and selectivity on COX-2 inhibition (COX-2 IC(50) = 0.07 microM; selectivity index = 201).	CHEMBL1243083	41-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	150-155
20691338-3	2010	Among the 1,2,3-triaryl-2-propen-1-ones, (Z)-1-(4-(methylsulfonyl)phenyl)-2,3-diphenylprop-2-en-1-one (3b) showed the most potency and selectivity on COX-2 inhibition (COX-2 IC(50) = 0.07 microM; selectivity index = 201).	CHEMBL1243083	41-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	168-173
20691338-4	2010	The Z-propenones were also found to be more potent and selective than their E-isomers for COX-2 inhibitory activity.	z-propenones	4-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-95
20691338-5	2010	The structure-activity data acquired indicate that the geometry of propenone and also the type of substituents on the C-3 propenone are important for COX-2 inhibitory activity.	propenone	67-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	150-155
20691338-5	2010	The structure-activity data acquired indicate that the geometry of propenone and also the type of substituents on the C-3 propenone are important for COX-2 inhibitory activity.	Carbon	118-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	150-155
20691338-5	2010	The structure-activity data acquired indicate that the geometry of propenone and also the type of substituents on the C-3 propenone are important for COX-2 inhibitory activity.	propenone	122-131	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	150-155
20495717-10	2010	Detection limits ranging from 7.5 x 10(-11) mol L(-1) for Co(II) to 8.3 x 10(-9) mol L(-1) for Pb(II) were achieved, which were about three orders lower than the present MCE-CL system.	mce-cl	170-176	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
20206688-2	2010	The NF-kappaB-dependent gene expression of IL8, IL6, PTGS2/COX2, TNF and IL33 in directly irradiated human skin fibroblasts produced the cytokines and prostaglandin E2 (PGE2) with autocrine/paracrine functions, which further activated signaling pathways and induced NF-kappaB-dependent gene expression in bystander cells.	Dinoprostone	151-167	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-63
20682995-0	2010	Antiproliferative effect of a novel nitro-oxy derivative of celecoxib in human colon cancer cells: role of COX-2 and nitric oxide.	Celecoxib	60-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-112
20682995-4	2010	The main findings were that the nitro-oxy derivative behaved like celecoxib in HT-29 cells in terms of COX-2 and ERK/MAPK inhibition, as well as induction of apoptosis, while the benzyl nitrate had no such effects.	nitro	32-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-108
20682995-4	2010	The main findings were that the nitro-oxy derivative behaved like celecoxib in HT-29 cells in terms of COX-2 and ERK/MAPK inhibition, as well as induction of apoptosis, while the benzyl nitrate had no such effects.	Celecoxib	66-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-108
20230798-6	2010	SPC also stimulates prostaglandin (PG) E(2) production by increasing cyclooxygenase (COX)-2 expression in NHK.	Dinoprostone	20-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-91
20539104-3	2010	Selective NSAIDs act on COX-1 (eg, aspirin) or COX-2 (eg, celecoxib) isoenzymes, respectively.	Celecoxib	58-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
20539104-7	2010	Prostaglandin production in inflamed tissue results from de novo induction of COX-2 expression by inflammatory cytokines and other noxious stimuli.	Prostaglandins	0-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-83
20470236-2	2010	As with all NSAIDs, diclofenac exerts its action via inhibition of prostaglandin synthesis by inhibiting cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) with relative equipotency.	Diclofenac	20-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-157
20470236-2	2010	As with all NSAIDs, diclofenac exerts its action via inhibition of prostaglandin synthesis by inhibiting cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) with relative equipotency.	Prostaglandins	67-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-157
20332057-1	2010	QSAR analyses were performed on a series of trans-stilbenoid diaryl compounds for modeling their COX-2 inhibitory activities.	trans-stilbenoid	44-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
20434816-0	2010	Mn(II), Co(II) and Zn(II) complexes with heterocyclic substituted thiosemicarbazones: synthesis, characterization, X-ray crystal structures and antitumor comparison.	Thiosemicarbazones	66-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	8-14
20361964-6	2010	Quercetin treatment protected ARPE-19 cells from H(2)O(2)-induced oxidative injury, enhanced BCL-2 transcript levels, increased the BCL-2/BAX ratio, suppressed the transcription of pro-apoptotic factors such as BAX, FADD, CASPASE-3 and CASPASE-9, inhibited the transcription of inflammatory factors such as TNF-alpha, COX-2 and INOS, and decreased the levels of COX and NO in the culture medium.	Quercetin	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	318-323
20699501-11	2010	CONCLUSION: Activated B and T cells express COX-1 and COX-2 in paraffin-embedded tissue sections of chronic tonsillitis.	Paraffin	63-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-59
20514410-0	2010	The endogenous cannabinoid, anandamide, induces COX-2-dependent cell death in apoptosis-resistant colon cancer cells.	Cannabinoids	15-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-53
20514410-0	2010	The endogenous cannabinoid, anandamide, induces COX-2-dependent cell death in apoptosis-resistant colon cancer cells.	anandamide	28-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-53
20514410-7	2010	Interestingly, increased COX-2 expression also sensitised the SW480 colorectal cancer cell line (low endogenous COX-2) to anandamide-induced death, whereas COX-2 suppression by RNAi inhibited anandamide-induced cell death in the HCA7 colorectal cancer cell line (high endogenous COX-2 expression).	anandamide	122-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-30
20514410-7	2010	Interestingly, increased COX-2 expression also sensitised the SW480 colorectal cancer cell line (low endogenous COX-2) to anandamide-induced death, whereas COX-2 suppression by RNAi inhibited anandamide-induced cell death in the HCA7 colorectal cancer cell line (high endogenous COX-2 expression).	anandamide	122-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-117
20514410-7	2010	Interestingly, increased COX-2 expression also sensitised the SW480 colorectal cancer cell line (low endogenous COX-2) to anandamide-induced death, whereas COX-2 suppression by RNAi inhibited anandamide-induced cell death in the HCA7 colorectal cancer cell line (high endogenous COX-2 expression).	anandamide	122-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-117
20514410-7	2010	Interestingly, increased COX-2 expression also sensitised the SW480 colorectal cancer cell line (low endogenous COX-2) to anandamide-induced death, whereas COX-2 suppression by RNAi inhibited anandamide-induced cell death in the HCA7 colorectal cancer cell line (high endogenous COX-2 expression).	anandamide	122-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-117
20514410-7	2010	Interestingly, increased COX-2 expression also sensitised the SW480 colorectal cancer cell line (low endogenous COX-2) to anandamide-induced death, whereas COX-2 suppression by RNAi inhibited anandamide-induced cell death in the HCA7 colorectal cancer cell line (high endogenous COX-2 expression).	anandamide	192-202	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-30
20514410-9	2010	This study demonstrates a novel utilisation for COX-2 expression, targeting apoptotic defective colorectal cancer cells for destruction by anandamide.	anandamide	139-149	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-53
20514410-10	2010	As COX-2 is not expressed in the normal colorectal epithelium, but highly expressed in colorectal tumours and apoptosis resistance contributes to treatment failure, these data suggest that anandamide has the potential to be an effective therapeutic in colorectal cancer.	anandamide	189-199	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	3-8
20154361-4	2010	10,12 CLA-mediated binding of NFkappaB to the promoters of interleukin (IL)-8 and cyclooxygenase (COX)-2 and induction of calcium-calmodulin kinase II (CaMKII) beta were attenuated by TMB-8.	Linoleic Acids, Conjugated	6-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-104
20154361-4	2010	10,12 CLA-mediated binding of NFkappaB to the promoters of interleukin (IL)-8 and cyclooxygenase (COX)-2 and induction of calcium-calmodulin kinase II (CaMKII) beta were attenuated by TMB-8.	8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate	184-189	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-104
20156557-5	2010	Calcitriol suppresses COX-2 expression and increases that of 15-PGDH thereby reducing the levels and biological activity of prostaglandins (PGs).	Calcitriol	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-27
20514441-4	2010	COX-2 inhibitors such as celecoxib are widely recognized to have antitumor activity, but can cause adverse effects.	Celecoxib	25-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
20514441-8	2010	NG-nitro-L-arginine-methyl ester (L-NAME) was used as a NOS inhibitor, dihydrochloride (1400W) as an iNOS inhibitor, and celecoxib as a selective COX-2 inhibitor.	Celecoxib	121-130	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	146-151
20514441-10	2010	Prostaglandin E2 (PGE2) production and COX-2 expression in KB/COX-2 were inhibited not only by celecoxib, but also by L-NAME and 1400W.	Dinoprostone	0-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
20514441-10	2010	Prostaglandin E2 (PGE2) production and COX-2 expression in KB/COX-2 were inhibited not only by celecoxib, but also by L-NAME and 1400W.	Celecoxib	95-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-44
20733946-4	2010	TGF-beta stimulation of human CD4(+) T cells induced COX-2-dependent production of PGE(2).	Prostaglandins E	83-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-58
20361960-4	2010	Since COX-2 isoform is overexpressed in colic inflammatory states, we examined the inhibitory effect of COX-2-inhibitors on P-gp expression and function under COX-2 stimulated conditions mediated by trinitrobenzene sulfonic acid (TNBS) in vitro, in Caco-2 cells, and in TNBS-induced colitis in mice.	Trinitrobenzenesulfonic Acid	199-228	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
20361960-4	2010	Since COX-2 isoform is overexpressed in colic inflammatory states, we examined the inhibitory effect of COX-2-inhibitors on P-gp expression and function under COX-2 stimulated conditions mediated by trinitrobenzene sulfonic acid (TNBS) in vitro, in Caco-2 cells, and in TNBS-induced colitis in mice.	Trinitrobenzenesulfonic Acid	199-228	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
20361960-7	2010	We showed that COX-2 stimulation in Caco-2 cells by 0.1mM TNBS exposure for 24h induced P-gp protein expression and activity.	Trinitrobenzenesulfonic Acid	58-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-20
20486105-0	2010	Cyanide-bridged [Co(II)2M(II)] and [Co(II)2M(II)2] complexes based on the [Co(II)(triphos)(CN)2] building block: syntheses, structures, magnetic properties, and density functional theoretical studies.	Cyanides	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-23
20486105-3	2010	In contrast, the [Co(2)Ni] is characterized by ferromagnetic interactions between the Co(II) and Ni(II) centers.	co(2)ni	18-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-92
21587759-1	2010	The asymmetric unit of the title compound, [Co(C(6)H(12)NO(4))(2)], contains one half-mol-ecule with the Co(II) ion situated on an inversion center.	co(c(6)h(12)no(4))(2)	44-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-111
20480065-6	2010	In the absence of base and in the presence of excess cobaltous acetate, trimetallic complexes were isolated containing a central Co(II) in an octahedral environment coordinated to four CH(3)OH and two bridging acetate ligands between two Co[O(2)NN"] fragments with Co(II) in a trigonal bipyramidal setting.	cobalt(II) acetate	53-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-135
20480065-6	2010	In the absence of base and in the presence of excess cobaltous acetate, trimetallic complexes were isolated containing a central Co(II) in an octahedral environment coordinated to four CH(3)OH and two bridging acetate ligands between two Co[O(2)NN"] fragments with Co(II) in a trigonal bipyramidal setting.	trimetallic	72-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-135
20480065-6	2010	In the absence of base and in the presence of excess cobaltous acetate, trimetallic complexes were isolated containing a central Co(II) in an octahedral environment coordinated to four CH(3)OH and two bridging acetate ligands between two Co[O(2)NN"] fragments with Co(II) in a trigonal bipyramidal setting.	trimetallic	72-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	265-271
20480065-6	2010	In the absence of base and in the presence of excess cobaltous acetate, trimetallic complexes were isolated containing a central Co(II) in an octahedral environment coordinated to four CH(3)OH and two bridging acetate ligands between two Co[O(2)NN"] fragments with Co(II) in a trigonal bipyramidal setting.	Acetates	63-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-135
20392577-8	2010	The genetic variations found in COI and COII can be applied not only to identify the species of forensic importance, but also to understand the taxonomic positions, generic or subgeneric status, of the sarcophagine species.	alanyltyrosine	202-214	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-44
20077021-4	2010	COX2 and DAPK methylation were significantly associated with CIMP+ and MSI.	cimp+	61-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-4
20590617-10	2010	Birb 796 and CBS-3868 showed a higher efficacy than SB203580 and pamapimod at inhibiting the expression of COX-2 and MMP13 genes, as well as PGE(2) release.	birb	0-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-112
20590617-10	2010	Birb 796 and CBS-3868 showed a higher efficacy than SB203580 and pamapimod at inhibiting the expression of COX-2 and MMP13 genes, as well as PGE(2) release.	SB 203580	52-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-112
20590617-10	2010	Birb 796 and CBS-3868 showed a higher efficacy than SB203580 and pamapimod at inhibiting the expression of COX-2 and MMP13 genes, as well as PGE(2) release.	pamapimod	65-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-112
20678677-3	2010	OBJECTIVE: The aim of this study was to assess the annual incidence of and identify the risk factors for clinical upper GI events in chronic COX-2 inhibitor (celecoxib and etoricoxib) users.	Celecoxib	158-167	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	141-146
20678677-3	2010	OBJECTIVE: The aim of this study was to assess the annual incidence of and identify the risk factors for clinical upper GI events in chronic COX-2 inhibitor (celecoxib and etoricoxib) users.	Etoricoxib	172-182	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	141-146
20678677-4	2010	METHODS: A prospective, hospital-based, observational cohort study was conducted in patients taking COX-2 inhibitors (celecoxib or etoricoxib) without comorbidity.	Celecoxib	118-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-105
20678677-4	2010	METHODS: A prospective, hospital-based, observational cohort study was conducted in patients taking COX-2 inhibitors (celecoxib or etoricoxib) without comorbidity.	Etoricoxib	131-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-105
20359903-5	2010	Aspirin being a COX-2 inhibitor has been shown to reduce the chance of metastasis in adenocarcinoma but not squamous carcinoma.	Aspirin	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-21
20591773-6	2010	The use of selective cyclo-oxygenase (COX)-2 inhibitor NSAIDs may be considered for patients at risk of gastrointestinal sequelae or those taking blood thinners such as warfarin.	Warfarin	169-177	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-44
20108347-6	2010	COX-2 inhibitors, indomethacin and N-39, blocked 50% of nodule formation.	Indomethacin	18-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
20549797-1	2010	BACKGROUND: This paper reports the catalytic oxidation of the concentrated orange oil phase using the complexes [Fe(III)(BMPP)Cl(micro-O)Fe(III)Cl(3)], [Cu(II)(BTMEA)(2)Cl]Cl and [Co(II)(BMPP)]Cl(2) biomimetic to methane monooxygenase enzyme as catalysts and hydrogen peroxide as oxidant.	fe(iii)(bmpp)cl	113-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	180-186
20549797-1	2010	BACKGROUND: This paper reports the catalytic oxidation of the concentrated orange oil phase using the complexes [Fe(III)(BMPP)Cl(micro-O)Fe(III)Cl(3)], [Cu(II)(BTMEA)(2)Cl]Cl and [Co(II)(BMPP)]Cl(2) biomimetic to methane monooxygenase enzyme as catalysts and hydrogen peroxide as oxidant.	fe(iii)cl(3)	137-149	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	180-186
20549797-1	2010	BACKGROUND: This paper reports the catalytic oxidation of the concentrated orange oil phase using the complexes [Fe(III)(BMPP)Cl(micro-O)Fe(III)Cl(3)], [Cu(II)(BTMEA)(2)Cl]Cl and [Co(II)(BMPP)]Cl(2) biomimetic to methane monooxygenase enzyme as catalysts and hydrogen peroxide as oxidant.	cu(ii)(btmea)(2)cl]	153-172	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	180-186
20549797-1	2010	BACKGROUND: This paper reports the catalytic oxidation of the concentrated orange oil phase using the complexes [Fe(III)(BMPP)Cl(micro-O)Fe(III)Cl(3)], [Cu(II)(BTMEA)(2)Cl]Cl and [Co(II)(BMPP)]Cl(2) biomimetic to methane monooxygenase enzyme as catalysts and hydrogen peroxide as oxidant.	Chlorine	193-198	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	180-186
20549797-1	2010	BACKGROUND: This paper reports the catalytic oxidation of the concentrated orange oil phase using the complexes [Fe(III)(BMPP)Cl(micro-O)Fe(III)Cl(3)], [Cu(II)(BTMEA)(2)Cl]Cl and [Co(II)(BMPP)]Cl(2) biomimetic to methane monooxygenase enzyme as catalysts and hydrogen peroxide as oxidant.	Hydrogen Peroxide	259-276	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	180-186
20514441-10	2010	Prostaglandin E2 (PGE2) production and COX-2 expression in KB/COX-2 were inhibited not only by celecoxib, but also by L-NAME and 1400W.	Celecoxib	95-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
20514441-10	2010	Prostaglandin E2 (PGE2) production and COX-2 expression in KB/COX-2 were inhibited not only by celecoxib, but also by L-NAME and 1400W.	NG-Nitroarginine Methyl Ester	118-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-44
20514441-10	2010	Prostaglandin E2 (PGE2) production and COX-2 expression in KB/COX-2 were inhibited not only by celecoxib, but also by L-NAME and 1400W.	NG-Nitroarginine Methyl Ester	118-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
20514441-10	2010	Prostaglandin E2 (PGE2) production and COX-2 expression in KB/COX-2 were inhibited not only by celecoxib, but also by L-NAME and 1400W.	N-((3-(aminomethyl)phenyl)methyl)ethanimidamide	129-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-44
20514441-10	2010	Prostaglandin E2 (PGE2) production and COX-2 expression in KB/COX-2 were inhibited not only by celecoxib, but also by L-NAME and 1400W.	N-((3-(aminomethyl)phenyl)methyl)ethanimidamide	129-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
20514441-11	2010	The decreases in PGE2 production and COX-2 expression were most prominent with celecoxib and L-NAME.	Celecoxib	79-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-42
20514441-11	2010	The decreases in PGE2 production and COX-2 expression were most prominent with celecoxib and L-NAME.	NG-Nitroarginine Methyl Ester	93-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-42
20514441-12	2010	In vivo, L-NAME and celecoxib significantly inhibited the proliferation of KB/COX-2-xenografted tumors.	NG-Nitroarginine Methyl Ester	9-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-83
20514441-12	2010	In vivo, L-NAME and celecoxib significantly inhibited the proliferation of KB/COX-2-xenografted tumors.	Celecoxib	20-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-83
20409747-1	2010	In this study, we prepared the Schiff base ligand (L) and its Cu(II), Co(II) and Ni(II) complexes.	Schiff Bases	31-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-87
20409747-9	2010	We investigated the improved catalytic activity of the Cu(II), Co(II) and Ni(II) complexes on the cyclohexane as a substrate.	Cyclohexane	98-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-69
20206142-0	2010	Endogenous N-acyl-dopamines induce COX-2 expression in brain endothelial cells by stabilizing mRNA through a p38 dependent pathway.	n-acyl-dopamines	11-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40
20206142-5	2010	We found that NADA activates a redox-sensitive p38 MAPK pathway that stabilizes COX-2 mRNA resulting in the accumulation of the COX-2 protein, which depends on the dopamine moiety of the molecule and that is independent of CB(1) and TRPV1 activation.	arachidonyl dopamine	14-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-85
20206142-5	2010	We found that NADA activates a redox-sensitive p38 MAPK pathway that stabilizes COX-2 mRNA resulting in the accumulation of the COX-2 protein, which depends on the dopamine moiety of the molecule and that is independent of CB(1) and TRPV1 activation.	arachidonyl dopamine	14-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	128-133
20206142-5	2010	We found that NADA activates a redox-sensitive p38 MAPK pathway that stabilizes COX-2 mRNA resulting in the accumulation of the COX-2 protein, which depends on the dopamine moiety of the molecule and that is independent of CB(1) and TRPV1 activation.	Dopamine	164-172	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-85
20206142-5	2010	We found that NADA activates a redox-sensitive p38 MAPK pathway that stabilizes COX-2 mRNA resulting in the accumulation of the COX-2 protein, which depends on the dopamine moiety of the molecule and that is independent of CB(1) and TRPV1 activation.	Dopamine	164-172	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	128-133
20206688-2	2010	The NF-kappaB-dependent gene expression of IL8, IL6, PTGS2/COX2, TNF and IL33 in directly irradiated human skin fibroblasts produced the cytokines and prostaglandin E2 (PGE2) with autocrine/paracrine functions, which further activated signaling pathways and induced NF-kappaB-dependent gene expression in bystander cells.	Dinoprostone	169-173	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-63
20206688-3	2010	As a result, bystander cells also started expression and production of interleukin-8, interleukin-6, COX-2-generated PGE2 and interleukin-33 (IL-33) followed by autocrine/paracrine stimulation of the NF-kappaB and MAPK pathways.	Dinoprostone	117-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-106
20455576-2	2010	The addition of Cu to reactions with Co(II), Fe(III), or Mn(II) leads to the formation of heterobimetallic UMCM-150 isostructural analogues Co(1)Cu(2)(BHTC)(2) (4), Fe(1)Cu(2)(BHTC)(2) (5), and Mn(1)Cu(2)(BHTC)(2) (6) containing both paddlewheel and trinuclear metal clusters.	Copper	16-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-43
20455576-2	2010	The addition of Cu to reactions with Co(II), Fe(III), or Mn(II) leads to the formation of heterobimetallic UMCM-150 isostructural analogues Co(1)Cu(2)(BHTC)(2) (4), Fe(1)Cu(2)(BHTC)(2) (5), and Mn(1)Cu(2)(BHTC)(2) (6) containing both paddlewheel and trinuclear metal clusters.	co(1)cu	140-147	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-43
20455576-2	2010	The addition of Cu to reactions with Co(II), Fe(III), or Mn(II) leads to the formation of heterobimetallic UMCM-150 isostructural analogues Co(1)Cu(2)(BHTC)(2) (4), Fe(1)Cu(2)(BHTC)(2) (5), and Mn(1)Cu(2)(BHTC)(2) (6) containing both paddlewheel and trinuclear metal clusters.	bhtc	151-155	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-43
20455576-2	2010	The addition of Cu to reactions with Co(II), Fe(III), or Mn(II) leads to the formation of heterobimetallic UMCM-150 isostructural analogues Co(1)Cu(2)(BHTC)(2) (4), Fe(1)Cu(2)(BHTC)(2) (5), and Mn(1)Cu(2)(BHTC)(2) (6) containing both paddlewheel and trinuclear metal clusters.	fe(1)	165-170	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-43
20455576-2	2010	The addition of Cu to reactions with Co(II), Fe(III), or Mn(II) leads to the formation of heterobimetallic UMCM-150 isostructural analogues Co(1)Cu(2)(BHTC)(2) (4), Fe(1)Cu(2)(BHTC)(2) (5), and Mn(1)Cu(2)(BHTC)(2) (6) containing both paddlewheel and trinuclear metal clusters.	Copper	145-147	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-43
20455576-2	2010	The addition of Cu to reactions with Co(II), Fe(III), or Mn(II) leads to the formation of heterobimetallic UMCM-150 isostructural analogues Co(1)Cu(2)(BHTC)(2) (4), Fe(1)Cu(2)(BHTC)(2) (5), and Mn(1)Cu(2)(BHTC)(2) (6) containing both paddlewheel and trinuclear metal clusters.	bhtc)	151-156	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-43
20455576-2	2010	The addition of Cu to reactions with Co(II), Fe(III), or Mn(II) leads to the formation of heterobimetallic UMCM-150 isostructural analogues Co(1)Cu(2)(BHTC)(2) (4), Fe(1)Cu(2)(BHTC)(2) (5), and Mn(1)Cu(2)(BHTC)(2) (6) containing both paddlewheel and trinuclear metal clusters.	cu(2)	145-150	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-43
20455576-2	2010	The addition of Cu to reactions with Co(II), Fe(III), or Mn(II) leads to the formation of heterobimetallic UMCM-150 isostructural analogues Co(1)Cu(2)(BHTC)(2) (4), Fe(1)Cu(2)(BHTC)(2) (5), and Mn(1)Cu(2)(BHTC)(2) (6) containing both paddlewheel and trinuclear metal clusters.	bhtc	176-180	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-43
20455576-2	2010	The addition of Cu to reactions with Co(II), Fe(III), or Mn(II) leads to the formation of heterobimetallic UMCM-150 isostructural analogues Co(1)Cu(2)(BHTC)(2) (4), Fe(1)Cu(2)(BHTC)(2) (5), and Mn(1)Cu(2)(BHTC)(2) (6) containing both paddlewheel and trinuclear metal clusters.	Metals	98-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-43
24061747-0	2010	Synthesis and Characterization of Co(II) Complexes of N-Thiophosphorylated Thioureas RC(S)NHP(S)(OiPr)2 (R = Me2N, 2-MeC6H4NH, 2,6-Me2C6H3NH, 2,4,6-Me3C6H2NH).	Nitrogen	54-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-39
21587689-2	2010	The Co(II) atom displays a distorted octa-hedral coordination geometry, provided by the O atoms of two monodentate ferrocene-carboxyl-ate anions and by the N and O atoms of two 2-pyridyl-methanol mol-ecule.	ferrocene-carboxyl-ate	115-137	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
21587689-2	2010	The Co(II) atom displays a distorted octa-hedral coordination geometry, provided by the O atoms of two monodentate ferrocene-carboxyl-ate anions and by the N and O atoms of two 2-pyridyl-methanol mol-ecule.	Nitrogen	156-157	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
21587689-2	2010	The Co(II) atom displays a distorted octa-hedral coordination geometry, provided by the O atoms of two monodentate ferrocene-carboxyl-ate anions and by the N and O atoms of two 2-pyridyl-methanol mol-ecule.	2-pyridyl-methanol	177-195	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
21587689-2	2010	The Co(II) atom displays a distorted octa-hedral coordination geometry, provided by the O atoms of two monodentate ferrocene-carboxyl-ate anions and by the N and O atoms of two 2-pyridyl-methanol mol-ecule.	mol-ecule	196-205	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
20556559-1	2010	INTRODUCTION: Flavocoxid, a botanical, anti-inflammatory agent, nonspecifically inhibits the peroxidase activity of cyclooxygenase (COX-1 and COX-2) enzymes and 5-lipooxygenase (5-LOX).	flavocoxid	14-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	142-147
20522940-2	2010	The Co(II) atom lies in a fairly regular tetrahedral geometry defined by two imidazole N-atom donors from one 2,5-bis[3-(1H-1,3-imidazol-1-ylmethyl)phenyl]-1,3,4-oxadiazole (L) ligand and two chloride anions.	imidazole n	77-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
24061747-0	2010	Synthesis and Characterization of Co(II) Complexes of N-Thiophosphorylated Thioureas RC(S)NHP(S)(OiPr)2 (R = Me2N, 2-MeC6H4NH, 2,6-Me2C6H3NH, 2,4,6-Me3C6H2NH).	Thiourea	75-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-39
20522940-2	2010	The Co(II) atom lies in a fairly regular tetrahedral geometry defined by two imidazole N-atom donors from one 2,5-bis[3-(1H-1,3-imidazol-1-ylmethyl)phenyl]-1,3,4-oxadiazole (L) ligand and two chloride anions.	2,5-bis[3-(1h-1,3-imidazol-1-ylmethyl)phenyl]-1,3,4-oxadiazole	110-172	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
20522940-2	2010	The Co(II) atom lies in a fairly regular tetrahedral geometry defined by two imidazole N-atom donors from one 2,5-bis[3-(1H-1,3-imidazol-1-ylmethyl)phenyl]-1,3,4-oxadiazole (L) ligand and two chloride anions.	Chlorides	192-200	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
24061747-0	2010	Synthesis and Characterization of Co(II) Complexes of N-Thiophosphorylated Thioureas RC(S)NHP(S)(OiPr)2 (R = Me2N, 2-MeC6H4NH, 2,6-Me2C6H3NH, 2,4,6-Me3C6H2NH).	(s)(oipr)2	93-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-39
24061747-0	2010	Synthesis and Characterization of Co(II) Complexes of N-Thiophosphorylated Thioureas RC(S)NHP(S)(OiPr)2 (R = Me2N, 2-MeC6H4NH, 2,6-Me2C6H3NH, 2,4,6-Me3C6H2NH).	4-Cyanophenyl 4-ethylbenzoate	109-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-39
24061747-0	2010	Synthesis and Characterization of Co(II) Complexes of N-Thiophosphorylated Thioureas RC(S)NHP(S)(OiPr)2 (R = Me2N, 2-MeC6H4NH, 2,6-Me2C6H3NH, 2,4,6-Me3C6H2NH).	2-mec6h4nh	115-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-39
24061747-0	2010	Synthesis and Characterization of Co(II) Complexes of N-Thiophosphorylated Thioureas RC(S)NHP(S)(OiPr)2 (R = Me2N, 2-MeC6H4NH, 2,6-Me2C6H3NH, 2,4,6-Me3C6H2NH).	2,6-me2c6h3nh	127-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-39
24061747-0	2010	Synthesis and Characterization of Co(II) Complexes of N-Thiophosphorylated Thioureas RC(S)NHP(S)(OiPr)2 (R = Me2N, 2-MeC6H4NH, 2,6-Me2C6H3NH, 2,4,6-Me3C6H2NH).	2,4,6-me3c6h2nh	142-157	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-39
20651346-4	2010	Following stimulation with different concentrations of the selective COX-2 inhibitor meloxicam, apoptosis was assessed immunohistochemically after 6 h and 12 h. All primary carcinomas and 56 out of the 57 liver metastases showed various degrees of cytoplasmatic COX-2 expression being with a reduction and in the liver metastases.	Meloxicam	85-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-74
20405237-4	2010	The results showed that sulforaphane inhibited the expression of COX-2 and iNOS stimulated by lipopolysaccharide in a dose- and time-dependent manner.	sulforaphane	24-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-70
20590583-2	2010	As COX-1 and COX-2 catalyse the first committed step in prostaglandin synthesis, recent efforts have focused on identifying the downstream prostaglandin signalling pathways responsible for mediating the toxic effect of COX-2.	Prostaglandins	56-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
20590583-2	2010	As COX-1 and COX-2 catalyse the first committed step in prostaglandin synthesis, recent efforts have focused on identifying the downstream prostaglandin signalling pathways responsible for mediating the toxic effect of COX-2.	Prostaglandins	56-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	219-224
20590583-2	2010	As COX-1 and COX-2 catalyse the first committed step in prostaglandin synthesis, recent efforts have focused on identifying the downstream prostaglandin signalling pathways responsible for mediating the toxic effect of COX-2.	Prostaglandins	139-152	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	219-224
20159031-3	2010	Elevated levels of COX-2 and concomitant overproduction of PGE(2) are often found in human cancers.	Prostaglandins E	59-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-24
20405237-6	2010	Pretreatment with SB202190, the specific inhibitor of p38, abolished the expression of COX-2 induced by LPS.	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	18-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-92
20405237-8	2010	Moreover, pretreatment with anisomycin (AM), an activator of p38 and JNK, instead of LPS, the expression of COX-2 and iNOS is still inhibited by sulforaphane.	Anisomycin	28-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-113
20578837-9	2010	The PI3K/Akt/COX-2 pathway was activated by radiation, whereas celecoxib inhibited the activation of the PI3K/Akt/COX-2 axis through several targets.	Celecoxib	63-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-119
20405237-8	2010	Moreover, pretreatment with anisomycin (AM), an activator of p38 and JNK, instead of LPS, the expression of COX-2 and iNOS is still inhibited by sulforaphane.	sulforaphane	145-157	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-113
20225070-5	2010	UV-vis studies of Co(II) and Fe(III) complexes confirm a metal-binding environment similar to previous di-Co(II)- and di-Fe(III)-DF proteins, including the presence of a mu-oxo-di-Fe(III) unit.	ferric sulfate	29-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-112
20225070-5	2010	UV-vis studies of Co(II) and Fe(III) complexes confirm a metal-binding environment similar to previous di-Co(II)- and di-Fe(III)-DF proteins, including the presence of a mu-oxo-di-Fe(III) unit.	Metals	57-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-24
20225070-5	2010	UV-vis studies of Co(II) and Fe(III) complexes confirm a metal-binding environment similar to previous di-Co(II)- and di-Fe(III)-DF proteins, including the presence of a mu-oxo-di-Fe(III) unit.	ferric sulfate	121-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-24
20531983-10	2010	Intracellular PGE(2) synthesis and expression of COX-2 was increased at post-2 h following FFSS.	Dinoprostone	14-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-54
20530583-6	2010	Suspecting that such cancers must rely on exogenous sources of prostaglandins, we show that pancreatic cancer stromal cells, such as fibroblasts expressing COX-1 and COX-2, are a likely source of prostaglandins for pancreatic cancer cells deficient in COX.	Prostaglandins	196-210	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	166-171
20200402-2	2010	The PGN-induced COX-2 expression was attenuated by the DNs of ASK1, JNK1, JNK2, a JNK inhibitor (SP600125), and an AP-1 inhibitor (curcumin).	pyrazolanthrone	97-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-21
20200402-2	2010	The PGN-induced COX-2 expression was attenuated by the DNs of ASK1, JNK1, JNK2, a JNK inhibitor (SP600125), and an AP-1 inhibitor (curcumin).	Curcumin	131-139	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-21
20200402-4	2010	In addition, PGN activated PP2A and suppression of PP2A by okadaic acid markedly inhibited PGN-induced ASK1 Ser967 dephosphorylation and COX-2 expression.	Okadaic Acid	59-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-142
19697035-7	2010	Hypoxia (2% O(2)) decreased IL-1beta-stimulated production of PGE(2), even though it increased the expression of mRNA and protein of COX-2.	o(2)	12-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	133-138
20227425-0	2010	The genotoxicity of physiological concentrations of chromium (Cr(III) and Cr(VI)) and cobalt (Co(II)): an in vitro study.	Cobalt	86-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-100
21491689-1	2010	The ditopic carbohydrazide and thiocarbohydrazide based ligands H2L1 and H2L2 react with Co(II)(OAc)2 to produce the homoleptic Co(II) molecular rectangles 1 and 2, containing either a mixture of high spin and low spin Co(II) sites or exclusively low spin Co(II) centers, respectively, with two mono-deprotonated ligands in a syn-conformation, and the other two doubly-deprotonated ligands in an anti-arrangement.	carbohydrazide	12-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	128-134
20405064-3	2010	Unusual selectivity for O(2) over N(2) (as high as 6.5) was demonstrated in the materials with open Co(ii) sites.	o(2)	24-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-106
20405064-3	2010	Unusual selectivity for O(2) over N(2) (as high as 6.5) was demonstrated in the materials with open Co(ii) sites.	Nitrogen	34-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-106
20419225-8	2010	Variable-temperature magnetic susceptibility measurements for 1 and 2 indicate a weak ferromagnetic interaction (J = +1.16 and +2.62/+2.70 cm(-1) for 1 and 2, respectively) between the two terminal Cr(III) (S(Cr) = 3/2) and the central high-spin Mn(II) (S(Mn) = 5/2) and Co(II) (S(Co) = 3/2) ions.	Chromium	198-200	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	271-277
21491689-1	2010	The ditopic carbohydrazide and thiocarbohydrazide based ligands H2L1 and H2L2 react with Co(II)(OAc)2 to produce the homoleptic Co(II) molecular rectangles 1 and 2, containing either a mixture of high spin and low spin Co(II) sites or exclusively low spin Co(II) centers, respectively, with two mono-deprotonated ligands in a syn-conformation, and the other two doubly-deprotonated ligands in an anti-arrangement.	carbohydrazide	12-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	128-134
21491689-1	2010	The ditopic carbohydrazide and thiocarbohydrazide based ligands H2L1 and H2L2 react with Co(II)(OAc)2 to produce the homoleptic Co(II) molecular rectangles 1 and 2, containing either a mixture of high spin and low spin Co(II) sites or exclusively low spin Co(II) centers, respectively, with two mono-deprotonated ligands in a syn-conformation, and the other two doubly-deprotonated ligands in an anti-arrangement.	thiocarbohydrazide	31-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-101
20433197-3	2010	As the deposition voltage is increased into the region where water oxidation prevails, the population of Co(IV) rises and the population of Co(II) decreases.	Water	61-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-146
21491689-1	2010	The ditopic carbohydrazide and thiocarbohydrazide based ligands H2L1 and H2L2 react with Co(II)(OAc)2 to produce the homoleptic Co(II) molecular rectangles 1 and 2, containing either a mixture of high spin and low spin Co(II) sites or exclusively low spin Co(II) centers, respectively, with two mono-deprotonated ligands in a syn-conformation, and the other two doubly-deprotonated ligands in an anti-arrangement.	thiocarbohydrazide	31-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-95
21491689-1	2010	The ditopic carbohydrazide and thiocarbohydrazide based ligands H2L1 and H2L2 react with Co(II)(OAc)2 to produce the homoleptic Co(II) molecular rectangles 1 and 2, containing either a mixture of high spin and low spin Co(II) sites or exclusively low spin Co(II) centers, respectively, with two mono-deprotonated ligands in a syn-conformation, and the other two doubly-deprotonated ligands in an anti-arrangement.	thiocarbohydrazide	31-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	128-134
21491689-1	2010	The ditopic carbohydrazide and thiocarbohydrazide based ligands H2L1 and H2L2 react with Co(II)(OAc)2 to produce the homoleptic Co(II) molecular rectangles 1 and 2, containing either a mixture of high spin and low spin Co(II) sites or exclusively low spin Co(II) centers, respectively, with two mono-deprotonated ligands in a syn-conformation, and the other two doubly-deprotonated ligands in an anti-arrangement.	thiocarbohydrazide	31-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	128-134
20372735-2	2010	The experimental data suggest that mefenamic acid acts as deprotonated monodentate ligand coordinated to Co(II) ion through a carboxylato oxygen.	Mefenamic Acid	35-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-111
20504378-1	2010	BACKGROUND AND OBJECTIVE: Our objective was to report on the design and essentials of the Etoricoxib protocol- Preemptive and Postoperative Analgesia (EPPA) Trial, investigating whether preemptive analgesia with cox-2 inhibitors is more efficacious than placebo in patients who receive either laparotomy or thoracotomy.	Etoricoxib	90-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	212-217
27713322-3	2010	In support of this possibility, recent molecular modeling studies have shown that the NSAID sulindac can be chemically modified to selectively design out its COX-1 and COX-2 inhibitory activity.	Sulindac	92-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	168-173
20372735-2	2010	The experimental data suggest that mefenamic acid acts as deprotonated monodentate ligand coordinated to Co(II) ion through a carboxylato oxygen.	Oxygen	138-144	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-111
20396812-1	2010	New monodimensional Co(II)/azido systems with unusual topological ferrimagnetic response have been characterised.	3',5-diazido-2',3'-dideoxyuridine	27-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-26
20396815-3	2010	In the N6 octahedral 4 : 1-type complex [Co(II)(L10)4](ClO4)2 H2O (25) both axially coordinating N1 unidentate and equatorially bound N2,N(pyr) bidentate ligands L10 are observed.	Water	62-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-47
20442906-1	2010	The novel transformation of cytosine oxime sulfonate (C*) to uracil sulfonate (U*) proceeded by a Co(II)-assisted benzoyl peroxide reaction, eventually leading to the conversion of cytosine to uracil.	cytosine oxime sulfonate	28-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-103
20442906-1	2010	The novel transformation of cytosine oxime sulfonate (C*) to uracil sulfonate (U*) proceeded by a Co(II)-assisted benzoyl peroxide reaction, eventually leading to the conversion of cytosine to uracil.	uracil sulfonate	61-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-103
20442906-1	2010	The novel transformation of cytosine oxime sulfonate (C*) to uracil sulfonate (U*) proceeded by a Co(II)-assisted benzoyl peroxide reaction, eventually leading to the conversion of cytosine to uracil.	Benzoyl Peroxide	114-130	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-103
20442906-1	2010	The novel transformation of cytosine oxime sulfonate (C*) to uracil sulfonate (U*) proceeded by a Co(II)-assisted benzoyl peroxide reaction, eventually leading to the conversion of cytosine to uracil.	Cytosine	28-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-103
20442906-1	2010	The novel transformation of cytosine oxime sulfonate (C*) to uracil sulfonate (U*) proceeded by a Co(II)-assisted benzoyl peroxide reaction, eventually leading to the conversion of cytosine to uracil.	Uracil	61-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-103
20824196-1	2010	Thermal decomposition of the trinuclear heterometallic oxoacetates [Fe(2)M(mu(3)-O)(CH(3)COO)(6)(H(2)O)(3)] has been used as a single-precursor method for synthesis of the spinel-structured ternary oxides MFe(2)O(4) (M = Mn(II), Co(II), and Ni(II)).	glyoxylic acid	55-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	229-234
20824196-1	2010	Thermal decomposition of the trinuclear heterometallic oxoacetates [Fe(2)M(mu(3)-O)(CH(3)COO)(6)(H(2)O)(3)] has been used as a single-precursor method for synthesis of the spinel-structured ternary oxides MFe(2)O(4) (M = Mn(II), Co(II), and Ni(II)).	ammonium ferrous sulfate	68-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	229-234
20824196-1	2010	Thermal decomposition of the trinuclear heterometallic oxoacetates [Fe(2)M(mu(3)-O)(CH(3)COO)(6)(H(2)O)(3)] has been used as a single-precursor method for synthesis of the spinel-structured ternary oxides MFe(2)O(4) (M = Mn(II), Co(II), and Ni(II)).	mu(3)-o	75-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	229-234
20387815-3	2010	It has been observed that compounds with one aryl ring on THP are moderate inhibitors of cyclooxygenase-1 (COX-1) (IC(50) = 0.3 microM) and cyclooxygenase-2 (IC(50) = 0.17 microM) with poor selectivity index (SI = 2-3) for COX-2.	thp	58-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	223-228
20376407-2	2010	Chemosensor 2 shows binding toward Cu(II), Ni(II) and Co(II) with color changes from yellow to dark red, red and pale green, respectively.	cu(ii)	35-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-60
20387815-5	2010	Selectivity for COX-2 over COX-1 also increased (SI = 50-1900), while triaryl substituted THPs, along with high inhibition (IC(50) = 0.57-4.0 nM), also exhibited excellent selectivity for COX-2 over COX-1 (SI = 3200-44000).	triaryl	70-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	188-193
20387815-5	2010	Selectivity for COX-2 over COX-1 also increased (SI = 50-1900), while triaryl substituted THPs, along with high inhibition (IC(50) = 0.57-4.0 nM), also exhibited excellent selectivity for COX-2 over COX-1 (SI = 3200-44000).	Pyroset TKP	90-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	188-193
27713316-2	2010	Aspirin and several small molecule NSAIDs are known to inhibit the enzymes cyclooxygenase-1 (COX-1) and -2 (COX-2).	Aspirin	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-113
20353154-1	2010	The isomerization dynamics of five labile octahedral Co(II) compounds have been investigated by variable temperature and pressure (1)H and (19)F NMR spectroscopy in dichloromethane solution.	Methylene Chloride	165-180	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-59
20353154-6	2010	A solid state structure/isomerization mechanism/rate correlation has been established for the isomerization dynamics of these Co(II) tris- and bis-chelates.	Tromethamine	133-137	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-132
20375691-3	2010	We investigated inhibition of COX-2 with NS398 in PC-3 and LNCaP cell lines.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	41-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-35
19954924-7	2010	However, combined treatment with subeffective doses of gamma-tocotrienol (0.25 microM) and celecoxib (2.5 microM) resulted in a synergistic antiproliferative effect, as determined by isobologram analysis, and this growth inhibitory effect was associated with a reduction in PGE(2) synthesis, and decrease in COX-2, phospho-Akt (active), and phospho-NFkappaB (active) levels.	plastochromanol 8	55-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	308-313
20375691-9	2010	These results suggest that TGF-beta1 can increase invasion and reverse inhibition of COX-2 induced by NS398.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	102-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-90
19954924-1	2010	The selective cyclooxygenase (COX)-2 inhibitor, celecoxib, and the vitamin E isoform, gamma-tocotrienol, both display potent anticancer activity.	Celecoxib	48-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-36
19946014-6	2010	The statin effect was reversed by mevalonate and geranylgeranyl-pyrophosphate and mimicked by the Rho inhibitor C3 transferase, indicating the involvement of Rho in the signal transduction pathway leading to COX-2 expression.	Mevalonic Acid	34-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	208-213
20032081-6	2010	Transient transfection experiments revealed that the induction of COX-2 promoter was significantly inhibited by RSG through an interference with the cAMP response element (CRE) site.	Rosiglitazone	112-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-71
20032081-6	2010	Transient transfection experiments revealed that the induction of COX-2 promoter was significantly inhibited by RSG through an interference with the cAMP response element (CRE) site.	Cyclic AMP	149-153	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-71
20334891-4	2010	Cobalt chemistry is dominated by the Co(II) oxidation state in the aqueous phase of terrestrial environments primarily due to the extremely low solubility of Co(III).	Cobalt	0-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-42
20424334-3	2010	The clinical experience of COX-2 selective inhibitors having unexpected adverse effects in patients with cardiovascular risk has opened up a debate about the role of COX-2-derived prostanoids in vascular pathophysiology.	Prostaglandins	180-191	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-32
20424334-3	2010	The clinical experience of COX-2 selective inhibitors having unexpected adverse effects in patients with cardiovascular risk has opened up a debate about the role of COX-2-derived prostanoids in vascular pathophysiology.	Prostaglandins	180-191	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	166-171
20424334-4	2010	PGI(2) is a major anti-atherogenic prostanoid produced by COX-2 in vascular cells, including endothelial and vascular smooth muscle cells.	Prostaglandins	35-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
20424334-5	2010	The balance between COX-2-derived PGI(2), COX-1-derived TXA(2), and other COX-2-mediated atherogenic prostanoids is a crucial factor in determining pathophysiological outcomes.	Prostaglandins	101-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
20486934-7	2010	PMA-mediated cell signaling leading to cyclooxygenase (COX)-2 expression and IkappaB downregulation was also inhibited, further confirming AD4-015 as a cell signaling inhibitor in tumor promoting conditions.	AD4 015	139-146	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-61
20399943-11	2010	GA with premedication: The cyclooxygenase (COX)-2 inhibitor etoricoxib; the nonselective COX inhibitors lornoxicam, diclofenac and ketorolac IM; and the opioid nalbuphine improved postoperative pain.	Etoricoxib	60-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-49
20133023-0	2010	New Cu(II), Co(II), Ni(II) complexes with aroyl-hydrazone based ligand.	aroyl-hydrazone	42-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-18
20133023-2	2010	A new aroyl-hydrazone, N-(2-pyridinecarbaldehyde)-N"-[4-(4-chloro-phenylsulfonyl) benzoyl]-hydrazone (L) and its Cu(II), Co(II) and Ni(II) complexes have been prepared.	aroyl-hydrazone	6-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-127
20133023-2	2010	A new aroyl-hydrazone, N-(2-pyridinecarbaldehyde)-N"-[4-(4-chloro-phenylsulfonyl) benzoyl]-hydrazone (L) and its Cu(II), Co(II) and Ni(II) complexes have been prepared.	n-(2-pyridinecarbaldehyde)-n"-[4-(4-chloro-phenylsulfonyl) benzoyl]-hydrazone	23-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-127
19739114-2	2010	Cyclo-oxygenase (COX)-2 inhibitors reduce OAC prostaglandin production but also have potentially detrimental effects on vascular endothelial function by reducing prostacyclin production and increasing the risk of cardiovascular events.	Prostaglandins	46-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-23
19739114-2	2010	Cyclo-oxygenase (COX)-2 inhibitors reduce OAC prostaglandin production but also have potentially detrimental effects on vascular endothelial function by reducing prostacyclin production and increasing the risk of cardiovascular events.	Epoprostenol	162-174	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-23
19739114-3	2010	We have examined the effects of inhibiting microsomal prostaglandin synthase-1 (mPGES-1), the enzyme downstream of COX-2 in the prostaglandin synthetic cascade.	Prostaglandins	54-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-120
19739114-6	2010	The anti-proliferative effects were equivalent to those produced by COX-2 inhibitory concentrations of celecoxib and NS-398.	Celecoxib	103-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-73
20372792-8	2010	In this study, we showed the implication of COX-2 and 5-LOX in diosgenin-induced apoptosis but these results demonstrate how difficult it is to assess the correlation between the apoptotic signalling pathway of diosgenin and arachidonic acid metabolism with certitude.	Diosgenin	63-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-55
20629404-2	2010	A microdrop of 1-hexyl-3-methylimidazolium hexafluorophosphate, [C6MIM][PF6], was used to extract Co(II) ions as an ammonium pyrroldinedithiocarbamate (APDC) complex.	1-hexyl-3-methylimidazolium	15-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-104
20629404-2	2010	A microdrop of 1-hexyl-3-methylimidazolium hexafluorophosphate, [C6MIM][PF6], was used to extract Co(II) ions as an ammonium pyrroldinedithiocarbamate (APDC) complex.	[c6mim][pf6]	64-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-104
20629404-2	2010	A microdrop of 1-hexyl-3-methylimidazolium hexafluorophosphate, [C6MIM][PF6], was used to extract Co(II) ions as an ammonium pyrroldinedithiocarbamate (APDC) complex.	ammonium pyrroldinedithiocarbamate	116-150	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-104
20629404-2	2010	A microdrop of 1-hexyl-3-methylimidazolium hexafluorophosphate, [C6MIM][PF6], was used to extract Co(II) ions as an ammonium pyrroldinedithiocarbamate (APDC) complex.	Ammonium pyrrolidyldithiocarbamate	152-156	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-104
20112284-6	2010	Moreover, COX-2-derived PGE(2) production appeared to involve in LPS-induced VCAM-1 expression which was attenuated by pretreatment with selective COX-2 inhibitors (NS-398 and celecoxib), transfection with COX-2 siRNA, or PGE(2) receptor antagonists.	Dinoprostone	24-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
20112284-6	2010	Moreover, COX-2-derived PGE(2) production appeared to involve in LPS-induced VCAM-1 expression which was attenuated by pretreatment with selective COX-2 inhibitors (NS-398 and celecoxib), transfection with COX-2 siRNA, or PGE(2) receptor antagonists.	Dinoprostone	24-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-152
20112284-6	2010	Moreover, COX-2-derived PGE(2) production appeared to involve in LPS-induced VCAM-1 expression which was attenuated by pretreatment with selective COX-2 inhibitors (NS-398 and celecoxib), transfection with COX-2 siRNA, or PGE(2) receptor antagonists.	Dinoprostone	24-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-152
20112284-6	2010	Moreover, COX-2-derived PGE(2) production appeared to involve in LPS-induced VCAM-1 expression which was attenuated by pretreatment with selective COX-2 inhibitors (NS-398 and celecoxib), transfection with COX-2 siRNA, or PGE(2) receptor antagonists.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	165-171	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
20112284-6	2010	Moreover, COX-2-derived PGE(2) production appeared to involve in LPS-induced VCAM-1 expression which was attenuated by pretreatment with selective COX-2 inhibitors (NS-398 and celecoxib), transfection with COX-2 siRNA, or PGE(2) receptor antagonists.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	165-171	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-152
20112284-6	2010	Moreover, COX-2-derived PGE(2) production appeared to involve in LPS-induced VCAM-1 expression which was attenuated by pretreatment with selective COX-2 inhibitors (NS-398 and celecoxib), transfection with COX-2 siRNA, or PGE(2) receptor antagonists.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	165-171	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-152
20112284-6	2010	Moreover, COX-2-derived PGE(2) production appeared to involve in LPS-induced VCAM-1 expression which was attenuated by pretreatment with selective COX-2 inhibitors (NS-398 and celecoxib), transfection with COX-2 siRNA, or PGE(2) receptor antagonists.	Celecoxib	176-185	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
20112284-6	2010	Moreover, COX-2-derived PGE(2) production appeared to involve in LPS-induced VCAM-1 expression which was attenuated by pretreatment with selective COX-2 inhibitors (NS-398 and celecoxib), transfection with COX-2 siRNA, or PGE(2) receptor antagonists.	Celecoxib	176-185	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-152
20112284-6	2010	Moreover, COX-2-derived PGE(2) production appeared to involve in LPS-induced VCAM-1 expression which was attenuated by pretreatment with selective COX-2 inhibitors (NS-398 and celecoxib), transfection with COX-2 siRNA, or PGE(2) receptor antagonists.	Celecoxib	176-185	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-152
20112284-6	2010	Moreover, COX-2-derived PGE(2) production appeared to involve in LPS-induced VCAM-1 expression which was attenuated by pretreatment with selective COX-2 inhibitors (NS-398 and celecoxib), transfection with COX-2 siRNA, or PGE(2) receptor antagonists.	Prostaglandins E	24-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
20112284-6	2010	Moreover, COX-2-derived PGE(2) production appeared to involve in LPS-induced VCAM-1 expression which was attenuated by pretreatment with selective COX-2 inhibitors (NS-398 and celecoxib), transfection with COX-2 siRNA, or PGE(2) receptor antagonists.	Prostaglandins E	24-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-152
20112284-6	2010	Moreover, COX-2-derived PGE(2) production appeared to involve in LPS-induced VCAM-1 expression which was attenuated by pretreatment with selective COX-2 inhibitors (NS-398 and celecoxib), transfection with COX-2 siRNA, or PGE(2) receptor antagonists.	Prostaglandins E	24-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-152
20213764-2	2010	3,3"-Diindolylmethane (B-DIM) is an inhibitor of NF-kappaB and COX-2 and is a well-known chemopreventive agent.	3,3'-diindolylmethane	0-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-68
20213764-2	2010	3,3"-Diindolylmethane (B-DIM) is an inhibitor of NF-kappaB and COX-2 and is a well-known chemopreventive agent.	b-dim	23-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-68
20213764-3	2010	We hypothesized that the inhibition of NF-kappaB and COX-2 by B-DIM concurrently with the inhibition of EGFR by erlotinib will potentiate the anti-tumor effects of cytotoxic drug gemcitabine, which has been tested both in vitro and in vivo.	gemcitabine	179-190	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-58
20082309-5	2010	Higher concentrations of IL-1beta-induced COX-2 mRNA and protein associated with an increase in PGE(2) and cAMP, and all of these parameters were potentiated by bFGF.	Prostaglandins E	96-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47
20082309-5	2010	Higher concentrations of IL-1beta-induced COX-2 mRNA and protein associated with an increase in PGE(2) and cAMP, and all of these parameters were potentiated by bFGF.	Cyclic AMP	107-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47
19954924-7	2010	However, combined treatment with subeffective doses of gamma-tocotrienol (0.25 microM) and celecoxib (2.5 microM) resulted in a synergistic antiproliferative effect, as determined by isobologram analysis, and this growth inhibitory effect was associated with a reduction in PGE(2) synthesis, and decrease in COX-2, phospho-Akt (active), and phospho-NFkappaB (active) levels.	Celecoxib	91-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	308-313
19954924-8	2010	These results demonstrate that the synergistic anticancer effects of combined celecoxib and gamma-tocotrienol therapy are mediated by COX-2 dependent and independent mechanisms.	Celecoxib	78-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-139
19954924-8	2010	These results demonstrate that the synergistic anticancer effects of combined celecoxib and gamma-tocotrienol therapy are mediated by COX-2 dependent and independent mechanisms.	plastochromanol 8	92-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-139
22966331-4	2010	BQ123, LY294002, SC203580 and AG1478 prevented the expression of COX-2 in the PC3 cells (P&lt;0.05), while BQ788 did not.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	7-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-70
20180883-3	2010	In this study, we investigated the relationship between CXCL12, cyclooxygenase (COX)-2 and PGE(2) in human brain cells.	Prostaglandins E	91-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-86
22966331-4	2010	BQ123, LY294002, SC203580 and AG1478 prevented the expression of COX-2 in the PC3 cells (P&lt;0.05), while BQ788 did not.	RTKI cpd	30-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-70
20631416-2	2010	The elucidation by John Vane of the mechanism of action of aspirin in 1971 was followed twenty years later by the discovery of a second cyclooxygenase enzyme, COX-2 and the rapid development of selective inhibitors of this enzyme.	Aspirin	59-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	159-164
20631409-12	2010	The thrombolytic actions of lipophilic ACE-Is (e.g., quinapril and perindopril) were prevented by pretreatment with either bradykinin B(2) receptor antagonists (e.g., icatibant) or with endothelial COX-2 inhibitors (e.g., rofecoxib, celecoxib and high dose aspirin).	Perindopril	67-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	198-203
20631416-3	2010	The COX-2 inhibitors are potent anti-inflammatory drugs without the damaging side effects on the stomach mucosa of the non-selective aspirin-like inhibitors.	Aspirin	133-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
20631416-5	2010	These are a putative cyclooxygenase-3 which is a variant of cyclooxygenase-1 and derives from the same gene, and a COX-2 variant, induced with diclofenac, which may be involved in the resolution of inflammation.	Diclofenac	143-153	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-120
20631418-3	2010	Although the tNSAID and coxib inhibition of COX-2-dependent prostaglandin (PG)E(2) production is effective in ameliorating symptoms of inflammation and pain, a small but consistent increased risk of myocardial infarction has been detected in association with their use.	Dinoprostone	60-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-49
20631418-4	2010	Convincing evidence suggests that cardiovascular toxicity associated with the administration of these compounds occurs through a common mechanism involving inhibition of COX-2-dependent prostacyclin.	Epoprostenol	186-198	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	170-175
20631418-8	2010	We propose that the assessment of COX-2 in whole blood ex vivo, either alone or in combination with urinary levels of 2,3-dinor-6-keto-PGF(1 alpha) a biomarker of prostacyclin biosynthesis in vivo, may represent a valid surrogate end-point to predict cardiovascular risk for functionally selective COX-2 inhibitors.	Epoprostenol	163-175	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-39
20306503-0	2010	Synthesis, magnetic properties, and STM spectroscopy of cobalt(II) Cubanes [Co(II) (4)(Cl)(4)(HL)(4)].	Cobalt(2+)	56-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-82
19960411-3	2010	Here, we demonstrate that 24-hydroxyursolic acid inhibited cell proliferation, strongly activated AMP-activated protein kinase (AMPK) and mediated critical anticancer effects by inhibition of cyclooxygenase (COX-2) expression in HT-29 cells.	24-hydroxyursolic acid	26-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	208-213
20033868-3	2010	Isoliquiritigenin (ILN), a flavonoid isolated from licorice (the rhizomes of GLYCYRRHIZA GLABRA, a member of the bean plant family), is known to be a potential suppressor of COX-2 expression.	isoliquiritigenin	0-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	174-179
20033868-4	2010	This study focuses on phorbol ester-induced COX-2 expression in the non-tumorigenic MCF-10A cells.	Phorbol Esters	22-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-49
20033868-5	2010	Real-time PCR and Western blotting indicated that ILN at 5 microM or above significantly inhibited phorbol 12-myristate 13-acetate (PMA)-induced COX-2 expression in the breast cells.	Tetradecanoylphorbol Acetate	99-130	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-150
20033868-5	2010	Real-time PCR and Western blotting indicated that ILN at 5 microM or above significantly inhibited phorbol 12-myristate 13-acetate (PMA)-induced COX-2 expression in the breast cells.	Tetradecanoylphorbol Acetate	132-135	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-150
20223228-8	2010	Treatment of aspirin significantly prevented the progression of nephropathy and inhibited the augmented COX-2, NFkappaB (p65 levels), TNFalpha, and TGFbeta-smad expression.	Aspirin	13-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
20309972-7	2010	Transition metal (Cd(II), Co(II), and Zn(II)) complexes with L-TBA(x)DA(y) self-assembled into rod-, tubule-, wire-, and platelike superstructures.	Metals	11-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-31
20309972-7	2010	Transition metal (Cd(II), Co(II), and Zn(II)) complexes with L-TBA(x)DA(y) self-assembled into rod-, tubule-, wire-, and platelike superstructures.	l-tba	61-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-31
20297799-6	2010	The ligand displays an increased selectivity for Zn(II) compared to 1 in the majority of cases with excellent selectivity upheld over Na(I), Mg(II), Ca(II), Mn(II), Ni(II), Co(II), and Fe(III).	Zinc	49-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	173-178
21579029-1	2010	In the title compound, [Co(C(2)H(8)NO(6)P(2))(2)(H(2)O)(2)] 9H(2)O, the Co(II) atom has a slightly distorted octa-hedral coordination environment consisting of four deprotonated phospho-nate O atoms of two independent 1-amino-ethyl-idendiphospho-nate anions and complemented by the O atoms of two water mol-ecules in cis positions.	co(c(2)h(8)no	24-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-78
20337489-1	2010	A hexacarboxamide cryptand featuring appended polyether moieties is used as a binucleating ligand for two Co(II) centers, marking the first time cryptands have been used as hexaanionic N donors for metal coordination.	hexacarboxamide	2-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-112
20337489-1	2010	A hexacarboxamide cryptand featuring appended polyether moieties is used as a binucleating ligand for two Co(II) centers, marking the first time cryptands have been used as hexaanionic N donors for metal coordination.	polyether	46-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-112
20337489-1	2010	A hexacarboxamide cryptand featuring appended polyether moieties is used as a binucleating ligand for two Co(II) centers, marking the first time cryptands have been used as hexaanionic N donors for metal coordination.	Metals	198-203	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-112
21579029-1	2010	In the title compound, [Co(C(2)H(8)NO(6)P(2))(2)(H(2)O)(2)] 9H(2)O, the Co(II) atom has a slightly distorted octa-hedral coordination environment consisting of four deprotonated phospho-nate O atoms of two independent 1-amino-ethyl-idendiphospho-nate anions and complemented by the O atoms of two water mol-ecules in cis positions.	(6)p(2))	37-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-78
21579029-1	2010	In the title compound, [Co(C(2)H(8)NO(6)P(2))(2)(H(2)O)(2)] 9H(2)O, the Co(II) atom has a slightly distorted octa-hedral coordination environment consisting of four deprotonated phospho-nate O atoms of two independent 1-amino-ethyl-idendiphospho-nate anions and complemented by the O atoms of two water mol-ecules in cis positions.	Hydrogen Peroxide	49-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-78
21579029-1	2010	In the title compound, [Co(C(2)H(8)NO(6)P(2))(2)(H(2)O)(2)] 9H(2)O, the Co(II) atom has a slightly distorted octa-hedral coordination environment consisting of four deprotonated phospho-nate O atoms of two independent 1-amino-ethyl-idendiphospho-nate anions and complemented by the O atoms of two water mol-ecules in cis positions.	9h(2)o	60-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-78
20333341-2	2010	The three compounds, formulated as [M(L)(H(2)O)(4)].2H(2)O (M = Co(ii), Mn(ii) and Ni(ii)), are isomorphic and consist of one-dimensional coordination chains formed by the dicarboxylate ligand bridging the metal ions using monodentate carboxylate groups.	Deuterium	52-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-70
20188945-1	2010	Functionalization of polyanthranilic acid (PAA) a self-doped conducting polymer with Co(II) metal complex has been reported and is used in the development of azidothymidine drug sensor.	polyanthranilic acid	21-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-91
20333341-4	2010	Magnetic studies on Ni(ii) and Co(ii) compounds reveal that the triple hydrogen bonding bridge transmits ferromagnetic coupling, with J = 3.46 cm(-1) for the Ni(ii) compound and J = 1.12 cm(-1) for the Co(ii) compound.	Hydrogen	71-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-25
20188945-1	2010	Functionalization of polyanthranilic acid (PAA) a self-doped conducting polymer with Co(II) metal complex has been reported and is used in the development of azidothymidine drug sensor.	paa	43-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-91
20188945-1	2010	Functionalization of polyanthranilic acid (PAA) a self-doped conducting polymer with Co(II) metal complex has been reported and is used in the development of azidothymidine drug sensor.	Metals	92-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-91
20188945-1	2010	Functionalization of polyanthranilic acid (PAA) a self-doped conducting polymer with Co(II) metal complex has been reported and is used in the development of azidothymidine drug sensor.	Zidovudine	158-172	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-91
20333341-4	2010	Magnetic studies on Ni(ii) and Co(ii) compounds reveal that the triple hydrogen bonding bridge transmits ferromagnetic coupling, with J = 3.46 cm(-1) for the Ni(ii) compound and J = 1.12 cm(-1) for the Co(ii) compound.	Hydrogen	71-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-37
20188945-2	2010	For the first time synthesis of a new type of polymer complex of Co(II)-cyclam macrocyclic ligand (1,4,8,11-tetraazacyclotetradecane) with carboxylated polymer (as a second ligand) has been successfully accomplished and discussed in the present paper.	Polymers	46-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-71
20333341-4	2010	Magnetic studies on Ni(ii) and Co(ii) compounds reveal that the triple hydrogen bonding bridge transmits ferromagnetic coupling, with J = 3.46 cm(-1) for the Ni(ii) compound and J = 1.12 cm(-1) for the Co(ii) compound.	Hydrogen	71-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-36
20188945-2	2010	For the first time synthesis of a new type of polymer complex of Co(II)-cyclam macrocyclic ligand (1,4,8,11-tetraazacyclotetradecane) with carboxylated polymer (as a second ligand) has been successfully accomplished and discussed in the present paper.	cyclam	99-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-71
20333341-4	2010	Magnetic studies on Ni(ii) and Co(ii) compounds reveal that the triple hydrogen bonding bridge transmits ferromagnetic coupling, with J = 3.46 cm(-1) for the Ni(ii) compound and J = 1.12 cm(-1) for the Co(ii) compound.	Hydrogen	71-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	202-208
20188945-2	2010	For the first time synthesis of a new type of polymer complex of Co(II)-cyclam macrocyclic ligand (1,4,8,11-tetraazacyclotetradecane) with carboxylated polymer (as a second ligand) has been successfully accomplished and discussed in the present paper.	Polymers	152-159	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-71
20188945-3	2010	The interaction of Co(II)-cyclam complex with polyanthranilic acid has been studied in solution phase using UV-vis spectra.	polyanthranilic acid	46-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-25
20379528-1	2010	A coordination polymer, [Co(II)(bIM)(acetate)] (bIM = benzimidazole) was synthesized using a solvothermal method; the complex has a two dimensional non-interpenetrated network structure and exhibits a spin-canted antiferromagnetic behaviour at low temperature and a high coercive field.	Polymers	15-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-31
20188945-5	2010	The characterization of solid mixed ligand complex Co(II)-cyclam-polyanthranilic acid (Co(II)-Cy-PAA) has been carried out for its structural, thermal and electrochemical properties using various techniques viz.	polyanthranilic acid	65-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-57
20188945-5	2010	The characterization of solid mixed ligand complex Co(II)-cyclam-polyanthranilic acid (Co(II)-Cy-PAA) has been carried out for its structural, thermal and electrochemical properties using various techniques viz.	polyanthranilic acid	65-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-93
20379528-1	2010	A coordination polymer, [Co(II)(bIM)(acetate)] (bIM = benzimidazole) was synthesized using a solvothermal method; the complex has a two dimensional non-interpenetrated network structure and exhibits a spin-canted antiferromagnetic behaviour at low temperature and a high coercive field.	benzimidazole	54-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-31
20178340-4	2010	5 s) and photoinduced valence tautomerism result in trapping of the metastable Co(II)-state at low temperatures through intermolecular hydrogen bonding.	Hydrogen	135-143	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-84
20074562-2	2010	The development of intestinal lesions induced by indomethacin was accompanied by increases in intestinal motility, enterobacterial invasion, and myeloperoxidase (MPO) as well as inducible nitric oxide synthase (iNOS) activity, together with the up-regulation of COX-2 and iNOS mRNA expression.	Indomethacin	49-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	262-267
20074562-4	2010	SC-560, but not rofecoxib, caused intestinal hypermotility, bacterial invasion and the expression of COX-2 as well as iNOS mRNA, yet the iNOS and MPO activity was increased only when rofecoxib was administered together with SC-560.	SC 560	0-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-106
20074562-6	2010	The intestinal hypermotility in response to indomethacin was prevented by both 16,16-dimethyl PGE(2) and atropine but not by ampicillin, yet all these agents inhibited not only the bacterial invasion but also the expression of COX-2 as well as the iNOS activity in the intestinal mucosa following indomethacin treatment, thereby preventing the intestinal damage.	Indomethacin	44-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	227-232
20074562-7	2010	These results suggest that inhibition of COX-1, despite causing intestinal hypermotility, bacterial invasion and iNOS expression, up-regulates the expression of COX-2, and the PGE(2) derived from COX-2 counteracts the deleterious events caused by COX-1 inhibition and maintains mucosal integrity.	Prostaglandins E	176-179	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	196-201
20103743-4	2010	Therefore, we tested the hypothesis that DHT alters COX-2 levels in the absence and presence of induced inflammation in primary human coronary artery smooth muscle cells (HCASMC).	Dihydrotestosterone	41-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-57
20103743-5	2010	Furthermore, we tested the ancillary hypothesis that DHT"s effects on COX-2 levels are AR-dependent.	Dihydrotestosterone	53-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-75
20103743-7	2010	Similar to previous observations in rodent arteries, in HCASMC, DHT alone increased COX-2 levels compared with vehicle.	Dihydrotestosterone	64-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-89
20103743-9	2010	Conversely, in the presence of LPS or IL-1beta, increases in COX-2 were attenuated by cotreatment with DHT.	Dihydrotestosterone	103-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-66
20103743-10	2010	Bicalutamide did not affect this response, suggesting that DHT-induced decreases in COX-2 levels occur independent of AR stimulation.	Dihydrotestosterone	59-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-89
20103743-11	2010	Thus we conclude that DHT differentially influences COX-2 levels under physiological and pathophysiological conditions in HCASMC.	Dihydrotestosterone	22-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-57
20103743-12	2010	This effect of DHT on COX-2 involves AR-dependent and- independent mechanisms, depending on the physiological state of the cell.	Dihydrotestosterone	15-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-27
20202839-4	2010	2-(1-Difluoromethyl-2-oxo-1,2-dihydropyridin-5-yl)acetic acid (7c) exhibited the best combination of dual COX-2 and 5-LOX inhibitory activities.	2-(1-difluoromethyl-2-oxo-1,2-dihydropyridin-5-yl)acetic acid	0-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-117
20577575-1	2010	Cyclooxygenase (COX)-2 enzyme catalyzes the rate-limiting step of prostaglandin formation in pathogenic states, and overexpression of COX-2 occurs at multiple stages of colon carcinogenesis, allowing elevated prostaglandin synthesis to occur in the tumor microenvironment.	Prostaglandins	66-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-22
19685055-0	2010	Celecoxib inhibits MDR1 expression through COX-2-dependent mechanism in human hepatocellular carcinoma (HepG2) cell line.	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
19685055-2	2010	Celecoxib, a selective inhibitor of COX-2, at 25 microM concentration increased the accumulation of doxorubicin in HepG2 cells and enhanced the sensitivity of the cells to doxorubicin by tenfold.	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-41
19685055-2	2010	Celecoxib, a selective inhibitor of COX-2, at 25 microM concentration increased the accumulation of doxorubicin in HepG2 cells and enhanced the sensitivity of the cells to doxorubicin by tenfold.	Doxorubicin	100-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-41
19685055-2	2010	Celecoxib, a selective inhibitor of COX-2, at 25 microM concentration increased the accumulation of doxorubicin in HepG2 cells and enhanced the sensitivity of the cells to doxorubicin by tenfold.	Doxorubicin	172-183	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-41
19685055-3	2010	The induction of MDR1 expression by PGE2 and its downregulation by celecoxib or by COX-2 knockdown suggests that the enhanced sensitivity of HepG2 cells to doxorubicin by celecoxib is mediated by the downregulation of MDR1 expression, through COX-2-dependent mechanism.	Dinoprostone	36-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
19685055-3	2010	The induction of MDR1 expression by PGE2 and its downregulation by celecoxib or by COX-2 knockdown suggests that the enhanced sensitivity of HepG2 cells to doxorubicin by celecoxib is mediated by the downregulation of MDR1 expression, through COX-2-dependent mechanism.	Dinoprostone	36-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	243-248
19685055-3	2010	The induction of MDR1 expression by PGE2 and its downregulation by celecoxib or by COX-2 knockdown suggests that the enhanced sensitivity of HepG2 cells to doxorubicin by celecoxib is mediated by the downregulation of MDR1 expression, through COX-2-dependent mechanism.	Doxorubicin	156-167	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
19685055-3	2010	The induction of MDR1 expression by PGE2 and its downregulation by celecoxib or by COX-2 knockdown suggests that the enhanced sensitivity of HepG2 cells to doxorubicin by celecoxib is mediated by the downregulation of MDR1 expression, through COX-2-dependent mechanism.	Celecoxib	171-180	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
20577575-1	2010	Cyclooxygenase (COX)-2 enzyme catalyzes the rate-limiting step of prostaglandin formation in pathogenic states, and overexpression of COX-2 occurs at multiple stages of colon carcinogenesis, allowing elevated prostaglandin synthesis to occur in the tumor microenvironment.	Prostaglandins	209-222	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-22
20577575-1	2010	Cyclooxygenase (COX)-2 enzyme catalyzes the rate-limiting step of prostaglandin formation in pathogenic states, and overexpression of COX-2 occurs at multiple stages of colon carcinogenesis, allowing elevated prostaglandin synthesis to occur in the tumor microenvironment.	Prostaglandins	209-222	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-139
20198345-2	2010	We studied the effects of an omega-3 PUFA, docahexaenoic acid (DHA) on COX-2 expression and the cell cycle control machinery that co-ordinately regulate the HCC cells growth.	docahexaenoic acid	43-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-76
20198345-2	2010	We studied the effects of an omega-3 PUFA, docahexaenoic acid (DHA) on COX-2 expression and the cell cycle control machinery that co-ordinately regulate the HCC cells growth.	Dihydroalprenolol	63-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-76
20089808-7	2010	An aminopyridine-based JNK inhibitor, N-(4-amino-5-cyano-6-ethoxypyridin-2-yl)-2-(2,5-dimethoxyphenyl)acetamide (JNK inhibitor VIII), inhibited phosphorylation of a JNK substrate c-Jun but did not have any effect on IL-6, IL-8, or COX-2 expression.	Aminopyridines	3-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	231-236
20436219-3	2010	The aim of the present study was to compare the effects of two different bile salts, deoxycholic acid (DCA) and ursodeoxycholic acid (UDCA) on the expression of COX-2, CDX-2 and DNA repair enzymes (MUTYH, OGG-1) in the Barrett epithelial cancer cells (OE-19).	Deoxycholic Acid	85-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	161-166
20436219-3	2010	The aim of the present study was to compare the effects of two different bile salts, deoxycholic acid (DCA) and ursodeoxycholic acid (UDCA) on the expression of COX-2, CDX-2 and DNA repair enzymes (MUTYH, OGG-1) in the Barrett epithelial cancer cells (OE-19).	Deoxycholic Acid	103-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	161-166
20436219-3	2010	The aim of the present study was to compare the effects of two different bile salts, deoxycholic acid (DCA) and ursodeoxycholic acid (UDCA) on the expression of COX-2, CDX-2 and DNA repair enzymes (MUTYH, OGG-1) in the Barrett epithelial cancer cells (OE-19).	Ursodeoxycholic Acid	112-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	161-166
20436219-6	2010	After incubation of OE-19 cells with bile salts, the expression of mRNA of COX-2, DNA repair enzymes (MUTYH, OGG-1) and caudal-related homebox transcription factor CDX-2 were measured by quantitative RT-PCR.	Bile Acids and Salts	37-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
20436219-10	2010	DCA caused stronger than UDCA stimulation of the COX-2 mRNA expression in these cells and this effect was significantly attenuated by the addition of inhibitor of NF kappaB activity (proteosome inhibitor MG-132).	Deoxycholic Acid	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-54
20436219-10	2010	DCA caused stronger than UDCA stimulation of the COX-2 mRNA expression in these cells and this effect was significantly attenuated by the addition of inhibitor of NF kappaB activity (proteosome inhibitor MG-132).	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	204-210	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-54
20436219-14	2010	We conclude that bile salts are involved in the carcinogenesis of Barrett adenocarcinoma via inhibition of DNA repair enzymes and induction of COX-2 and this last effect is, at least partly, mediated by NF kappaB.	Bile Acids and Salts	17-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	143-148
20363696-2	2010	Etoricoxib is a new non-steroidal anti-inflammatory drug (NSAID) with selective cox-2 inhibitory activity, selective inhibition of cox-2 provides anti-inflammatory and analgesic activity it is commonly used for osteo-arthritis, rheumatoid arthritis, primary dysmenorrhoea, post operative dental pain and acute gout.	Etoricoxib	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-85
20363696-2	2010	Etoricoxib is a new non-steroidal anti-inflammatory drug (NSAID) with selective cox-2 inhibitory activity, selective inhibition of cox-2 provides anti-inflammatory and analgesic activity it is commonly used for osteo-arthritis, rheumatoid arthritis, primary dysmenorrhoea, post operative dental pain and acute gout.	Etoricoxib	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-136
19808012-3	2010	Since COX-1 and COX-2 catalyze the first committed step in prostaglandin synthesis, an effort is underway to identify the downstream prostaglandin signaling pathways that mediate the toxic effect of COX-2.	Prostaglandins	59-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-21
19808012-3	2010	Since COX-1 and COX-2 catalyze the first committed step in prostaglandin synthesis, an effort is underway to identify the downstream prostaglandin signaling pathways that mediate the toxic effect of COX-2.	Prostaglandins	59-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	199-204
19808012-3	2010	Since COX-1 and COX-2 catalyze the first committed step in prostaglandin synthesis, an effort is underway to identify the downstream prostaglandin signaling pathways that mediate the toxic effect of COX-2.	Prostaglandins	133-146	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	199-204
19808012-4	2010	Recent epidemiologic studies demonstrate that chronic COX-2 inhibition can produce adverse cerebrovascular and cardiovascular effects, indicating that some prostaglandin signaling pathways are beneficial.	Prostaglandins	156-169	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-59
20116423-2	2010	In this study, we investigated the effects of NSAIDs (aspirin or indomethacin) and COX-2 inhibitor (NS-398) on growth of YD-8 human oral squamous carcinoma cells.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	100-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
20116423-2	2010	In this study, we investigated the effects of NSAIDs (aspirin or indomethacin) and COX-2 inhibitor (NS-398) on growth of YD-8 human oral squamous carcinoma cells.	yd-8	121-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
20215464-3	2010	Using an advanced computational technique we have simulated the full dissociation process of a highly potent and selective inhibitor, SC-558, in both COX-1 and COX-2.	SC 558	134-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	160-165
20184343-1	2010	A highly effective Co(II)-based system has been developed for catalytic intramolecular C-H amination with phosphoryl azides without the need of terminal oxidant or other additives, resulting in the high-yielding production of cyclophosphoramidates with nitrogen gas as the byproduct.	Azides	117-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-24
20184343-1	2010	A highly effective Co(II)-based system has been developed for catalytic intramolecular C-H amination with phosphoryl azides without the need of terminal oxidant or other additives, resulting in the high-yielding production of cyclophosphoramidates with nitrogen gas as the byproduct.	cyclophosphoramidates	226-247	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-24
20184343-1	2010	A highly effective Co(II)-based system has been developed for catalytic intramolecular C-H amination with phosphoryl azides without the need of terminal oxidant or other additives, resulting in the high-yielding production of cyclophosphoramidates with nitrogen gas as the byproduct.	Nitrogen	253-261	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-24
20036733-7	2010	UVB-irradiated KP provoked an appreciable accumulation of pSer(15)-p53/COX-2 complexes, but this nuclear association of complexes was partially inhibited by PD98059.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	157-164	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-76
20151687-1	2010	The synthesis and nuclear and magnetic structures from the powder diffraction of Co(II)(5)(OH)(6)(SeO(4))(2)(H(2)O)(4) and its deuterated analogues as well as their infrared spectral, thermal, and magnetic properties are reported.	seo(4)	98-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-87
20054003-2	2010	We have recently demonstrated that celecoxib and its COX-2-independent analogue 4-trifluoromethyl-celecoxib (TFM-C) inhibit secretion but not transcription of IL-12 (p35/p40) and p80 (p40/p40).	4-trifluoromethyl-celecoxib	80-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-58
20054003-2	2010	We have recently demonstrated that celecoxib and its COX-2-independent analogue 4-trifluoromethyl-celecoxib (TFM-C) inhibit secretion but not transcription of IL-12 (p35/p40) and p80 (p40/p40).	tfm-c	109-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-58
20117092-6	2010	Moreover, GalphaqQL mediated UVB-induced COX-2 expression in an HB-EGF-, EGFR-, and p38-dependent manner.	galphaqql	10-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-46
20117092-7	2010	From these results, we concluded that Galphaq mediates UV-induced COX-2 expression through activation of EGFR by HB-EGF, of which ectodomain shedding was stimulated through sequential activation of PLC, PKCdelta and MMP-2 in HaCaT cells.	galphaq	38-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-71
20131859-3	2010	The largest enhancement in the emitted intensity occurs for the reaction of LUM with Co(II) in the presence of beta-CD.	betadex	111-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-91
20141189-2	2010	The Co-N bond length changes and the transient spectra and kinetics have been measured and in combination with DFT theoretical calculations are used to determine the photochemical mechanism of the Co(III) to Co(II) redox reaction.	co-n	4-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	208-214
20141189-3	2010	The data presented show that the Co-N bond length changes from the Co(III)-N 1.93 A length to the 2.12 A Co(II)-N length within 2 ps and then remains constant for at least 100 ps.	co-n	33-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-111
20356270-2	2010	The polymer films electrogenerated from the bithienyl (4b) and terthienyl (4c) derivatives display redox processes attributed to the Co(III)/Co(II) couple at ca.	Polymers	4-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	133-138
21488266-1	2010	The synthesis, structure and magnetic properties of a 3D network based on {Co4(cit)4}8- (H4cit = citric acid) cubane units linked by octahedral Co(II) centres is reported.	co4(cit)4	75-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	144-150
21488266-1	2010	The synthesis, structure and magnetic properties of a 3D network based on {Co4(cit)4}8- (H4cit = citric acid) cubane units linked by octahedral Co(II) centres is reported.	Citric Acid	97-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	144-150
21488316-1	2010	Isostructural Co(II)2Co(III)4Ln(III)4 (Ln = Y (1), Gd (2) and Dy (3)) coordination clusters formed using the ligand Tris are the first examples of 3d-4f complexes involving this ligand and show weak ferromagnetic coupling between the Co(II) ions and slow relaxation (SMM) behaviour for 3.	Cobalt(2+)	14-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	234-240
21491689-1	2010	The ditopic carbohydrazide and thiocarbohydrazide based ligands H2L1 and H2L2 react with Co(II)(OAc)2 to produce the homoleptic Co(II) molecular rectangles 1 and 2, containing either a mixture of high spin and low spin Co(II) sites or exclusively low spin Co(II) centers, respectively, with two mono-deprotonated ligands in a syn-conformation, and the other two doubly-deprotonated ligands in an anti-arrangement.	carbohydrazide	12-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-101
21491689-1	2010	The ditopic carbohydrazide and thiocarbohydrazide based ligands H2L1 and H2L2 react with Co(II)(OAc)2 to produce the homoleptic Co(II) molecular rectangles 1 and 2, containing either a mixture of high spin and low spin Co(II) sites or exclusively low spin Co(II) centers, respectively, with two mono-deprotonated ligands in a syn-conformation, and the other two doubly-deprotonated ligands in an anti-arrangement.	carbohydrazide	12-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-95
20089330-0	2010	New dimeric cyclodiphosph(V)azane complexes of Cr(III), Co(II), Ni(II), Cu(II), and Zn(II): preparation, characterization and biological activity studies.	cyclodiphosph	12-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-62
20089330-0	2010	New dimeric cyclodiphosph(V)azane complexes of Cr(III), Co(II), Ni(II), Cu(II), and Zn(II): preparation, characterization and biological activity studies.	Ammonia	28-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-62
20436219-3	2010	The aim of the present study was to compare the effects of two different bile salts, deoxycholic acid (DCA) and ursodeoxycholic acid (UDCA) on the expression of COX-2, CDX-2 and DNA repair enzymes (MUTYH, OGG-1) in the Barrett epithelial cancer cells (OE-19).	Bile Acids and Salts	73-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	161-166
19820419-7	2010	The COX-2-positive BxPC-3 but not the COX-2-negative MiaPaCa-2 treated with 100-nmol/L PGE2 induced phosphorylated extracellular signal-related kinase that was blocked by the mitogen-activated protein kinase kinase inhibitor U0126, demonstrating the ability of PGE2 to activate ERK.	Dinoprostone	87-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
19820419-7	2010	The COX-2-positive BxPC-3 but not the COX-2-negative MiaPaCa-2 treated with 100-nmol/L PGE2 induced phosphorylated extracellular signal-related kinase that was blocked by the mitogen-activated protein kinase kinase inhibitor U0126, demonstrating the ability of PGE2 to activate ERK.	U 0126	225-230	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
19820419-7	2010	The COX-2-positive BxPC-3 but not the COX-2-negative MiaPaCa-2 treated with 100-nmol/L PGE2 induced phosphorylated extracellular signal-related kinase that was blocked by the mitogen-activated protein kinase kinase inhibitor U0126, demonstrating the ability of PGE2 to activate ERK.	Dinoprostone	261-265	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
19820419-8	2010	CONCLUSIONS: These results suggest that enhanced PGE2 production proceeds through the expressions of COX-2 and microsomal PGES-1 and down-regulation of PGDH by SNAI2 in pancreatic tumors.	Dinoprostone	49-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-106
20004183-0	2010	Purification of a peptide from seahorse, that inhibits TPA-induced MMP, iNOS and COX-2 expression through MAPK and NF-kappaB activation, and induces human osteoblastic and chondrocytic differentiation.	Tetradecanoylphorbol Acetate	55-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-86
19711347-1	2010	The present study investigated the preventive effects of etodolac, a selective cyclo-oxygenase (COX)-2 inhibitor, on metachronous cancer development after endoscopic resection of early gastric cancer.	Etodolac	57-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-102
19963049-1	2010	Recent studies have shown that COX-2 inhibitors, such as meloxicam, have demonstrated promising results when used with chemotherapy.	Meloxicam	57-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-36
20036733-5	2010	Elevation of the COX-2 levels was inhibited by an NADPH oxidase inhibitor and an NF-kappaB inhibitor but was largely enhanced after glutathione depletion by buthionine sulfoximine.	Glutathione	132-143	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22
20036733-5	2010	Elevation of the COX-2 levels was inhibited by an NADPH oxidase inhibitor and an NF-kappaB inhibitor but was largely enhanced after glutathione depletion by buthionine sulfoximine.	Buthionine Sulfoximine	157-179	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22
20202516-1	2010	OBJECTIVES: The purpose of this study was to determine whether single-dose rosuvastatin (40 mg) protects against ischemia and reperfusion (IR)-induced endothelial dysfunction in humans and whether this effect is cyclooxygenase (COX)-2 dependent.	Rosuvastatin Calcium	75-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	212-234
20202516-5	2010	In a separate protocol, 18 volunteers received the COX-2 inhibitor celecoxib (200 mg orally twice daily) for 5 days.	Celecoxib	67-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-56
20202516-12	2010	This beneficial effect of rosuvastatin is mediated by a COX-2-dependent mechanism, evidence that may also provide potential mechanistic insight into the reported cardiotoxic effects of COX-2 inhibitors.	Rosuvastatin Calcium	26-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-61
20202516-12	2010	This beneficial effect of rosuvastatin is mediated by a COX-2-dependent mechanism, evidence that may also provide potential mechanistic insight into the reported cardiotoxic effects of COX-2 inhibitors.	Rosuvastatin Calcium	26-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	185-190
20100477-1	2010	Here we report that miR-26b is involved in COX-2 overexpression in desferrioxamine (DFOM)-treated carcinoma of nasopharyngeal epithelial (CNE) cells.	Deferoxamine	67-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
20100477-1	2010	Here we report that miR-26b is involved in COX-2 overexpression in desferrioxamine (DFOM)-treated carcinoma of nasopharyngeal epithelial (CNE) cells.	Deferoxamine	84-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
20100477-2	2010	The level of miR-26b in DFOM-treated CNE cells is inversely proportional to the expression level of the COX-2 protein.	Deferoxamine	24-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
20100477-5	2010	Overexpression of miR-26b marginally reduces the levels of COX-2 protein in DFOM-treated CNE cells.	Deferoxamine	76-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-64
20100477-7	2010	Taken together, these results suggest that miR-26b regulates COX-2 expression in DFOM-treated cells.	Deferoxamine	81-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-66
20162209-2	2010	The X-ray crystal structure of 2 consists of neutral oxalato-bridged Cr(III)(2)Co(II) bent entities formed by the coordination of two anionic [Cr(III)(phen)(ox)(2)](-) complexes through one of their oxalato groups toward a cationic cis-[Co(II)(Me(2)bpy)](2+) complex.	cr(iii)(phen)(ox)(2)	143-163	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-85
20162209-4	2010	The intermolecular pi-pi stacking interactions between the enantiomeric pairs of heterochiral Cr(III)(2)Co(II) entities through the aromatic diimine terminal ligands lead to a unique two-dimensional supramolecular network.	diazene	141-148	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-110
20200425-1	2010	BACKGROUND: Prostaglandin-endoperoxide synthase 2 (PTGS2, the HUGO Gene Nomenclature Committee-approved official symbol for cycloxygenase-2, COX-2) and its enzymatic product prostaglandin E2 have critical roles in inflammation and carcinogenesis through the G protein-coupled receptor PTGER2 (EP2).	Dinoprostone	174-190	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	141-146
20233202-0	2010	Aspirin-triggered lipoxin in patients treated with aspirin and selective vs. nonselective COX-2 inhibitors.	Aspirin	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-95
20233202-0	2010	Aspirin-triggered lipoxin in patients treated with aspirin and selective vs. nonselective COX-2 inhibitors.	Lipoxins	18-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-95
20233202-1	2010	AIMS: Cyclooxygenase (COX)-2 inhibition has been reported to suppress the biosynthesis of the gastroprotective lipoxygenase metabolite 15(R)-epi-lipoxin A(4), also termed "aspirin-triggered lipoxin" (ATL).	15(r)-epi-lipoxin a	135-154	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	6-28
20233202-1	2010	AIMS: Cyclooxygenase (COX)-2 inhibition has been reported to suppress the biosynthesis of the gastroprotective lipoxygenase metabolite 15(R)-epi-lipoxin A(4), also termed "aspirin-triggered lipoxin" (ATL).	15(R)-HETE(1-)	172-197	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	6-28
20233202-2	2010	We tested the hypothesis that the co-administration of aspirin with either the selective COX-2 inhibitor celecoxib or the nonselective COX inhibitor ibuprofen reduces ATL biosynthesis.	Aspirin	55-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-94
20233202-2	2010	We tested the hypothesis that the co-administration of aspirin with either the selective COX-2 inhibitor celecoxib or the nonselective COX inhibitor ibuprofen reduces ATL biosynthesis.	Celecoxib	105-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-94
19748095-2	2010	The aim of this study was to investigate if the polymorphisms COX2 T8473C (rs5275), and COX2 A-1195G (rs689466), which modify the enzyme levels of COX-2, were associated with risk of ACS and if alcohol intake, smoking, and use of NSAID would modify the associations.	Alcohols	194-201	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-66
19748095-2	2010	The aim of this study was to investigate if the polymorphisms COX2 T8473C (rs5275), and COX2 A-1195G (rs689466), which modify the enzyme levels of COX-2, were associated with risk of ACS and if alcohol intake, smoking, and use of NSAID would modify the associations.	Alcohols	194-201	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-92
19748095-2	2010	The aim of this study was to investigate if the polymorphisms COX2 T8473C (rs5275), and COX2 A-1195G (rs689466), which modify the enzyme levels of COX-2, were associated with risk of ACS and if alcohol intake, smoking, and use of NSAID would modify the associations.	Alcohols	194-201	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-152
19748095-7	2010	Among males, there was interaction between COX-2 T8473C and alcohol in relation to total cholesterol, non-HDL cholesterol and LDL levels (p for interaction: 0.003, 0.007 and 0.01, respectively), such that variant allele carriers with low alcohol intake had the lowest lipid levels.	Alcohols	60-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
19748095-7	2010	Among males, there was interaction between COX-2 T8473C and alcohol in relation to total cholesterol, non-HDL cholesterol and LDL levels (p for interaction: 0.003, 0.007 and 0.01, respectively), such that variant allele carriers with low alcohol intake had the lowest lipid levels.	Cholesterol	89-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
19748095-7	2010	Among males, there was interaction between COX-2 T8473C and alcohol in relation to total cholesterol, non-HDL cholesterol and LDL levels (p for interaction: 0.003, 0.007 and 0.01, respectively), such that variant allele carriers with low alcohol intake had the lowest lipid levels.	Cholesterol	110-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
19748095-7	2010	Among males, there was interaction between COX-2 T8473C and alcohol in relation to total cholesterol, non-HDL cholesterol and LDL levels (p for interaction: 0.003, 0.007 and 0.01, respectively), such that variant allele carriers with low alcohol intake had the lowest lipid levels.	Alcohols	238-245	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
20144869-3	2010	In addition, it displayed PGE(2) inhibition in a cell-based assay (0.42microM) and had over 238-fold selectivity for mPGES-1 over COX-2 and over 200-fold selectivity for mPGES-1 over 6-keto PGF(1alpha).	Prostaglandins E	26-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	130-135
20145188-4	2010	Supplementation of medium with phosphate increased anchorage-independent transformation and proliferation of BALB/c mouse JB6 epidermal cells, activation of N-ras, ERK1/2, and activator protein-1, and increased gene expression of Fra-1, COX-2, and osteopontin in a dose-dependent manner.	Phosphates	31-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	237-242
20092437-3	2010	Large retrospective analyses of clinical data have repeatedly shown that diclofenac, similar as some selective COX-2 inhibitors, increases the propensity to experience adverse cardiovascular and atherothrombotic events.	Diclofenac	73-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	111-116
20092437-5	2010	The reasons for this novel side-effect of diclofenac may be based on the specific pharmacology of diclofenac, which, similar to selective COX-2 inhibitors, alters vascular levels of platelet active prostaglandins in a way that favours arterial thrombosis.	Diclofenac	42-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	138-143
20092437-5	2010	The reasons for this novel side-effect of diclofenac may be based on the specific pharmacology of diclofenac, which, similar to selective COX-2 inhibitors, alters vascular levels of platelet active prostaglandins in a way that favours arterial thrombosis.	Diclofenac	98-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	138-143
20193113-1	2010	BACKGROUND AND OBJECTIVE: Celecoxib, one of the new generation of non-steroidal anti-inflammatory drugs (NSAIDs), has a specific inhibitory effect on COX-2.	Celecoxib	26-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	150-155
20179228-7	2010	Nonetheless, as a key rate-limiting control point of PG biosynthesis, COX-2 continues to be an important anticancer target.	Prostaglandins	53-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-75
20346263-3	2010	REVIEW METHODS: Randomised controlled trials comparing paracetamol, NSAIDs or COX-2 inhibitors to each other or placebo, in adults receiving patient-controlled analgesia (PCA) with morphine following major surgery, were included.	Morphine	181-189	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-83
20346263-15	2010	When paracetamol, NSAIDs or COX-2 inhibitors were added to PCA morphine, there was a statistically significant reduction in morphine consumption: paracetamol (MD -6.34 mg; 95% CrI -9.02 to -3.65); NSAIDs (MD -10.18; 95% CrI -11.65 to -8.72); and COX-2 inhibitors (MD -10.92; 95% CrI -12.77 to -9.08).	Acetaminophen	146-157	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
20346263-15	2010	When paracetamol, NSAIDs or COX-2 inhibitors were added to PCA morphine, there was a statistically significant reduction in morphine consumption: paracetamol (MD -6.34 mg; 95% CrI -9.02 to -3.65); NSAIDs (MD -10.18; 95% CrI -11.65 to -8.72); and COX-2 inhibitors (MD -10.92; 95% CrI -12.77 to -9.08).	Acetaminophen	5-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	246-251
20346263-18	2010	CONCLUSIONS: 24-hour morphine consumption decreased by 6.3 mg to 10.9 mg, compared to placebo, when paracetamol, NSAID or COX-2 inhibitors were added to PCA morphine following surgery.	Morphine	21-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-127
20346263-15	2010	When paracetamol, NSAIDs or COX-2 inhibitors were added to PCA morphine, there was a statistically significant reduction in morphine consumption: paracetamol (MD -6.34 mg; 95% CrI -9.02 to -3.65); NSAIDs (MD -10.18; 95% CrI -11.65 to -8.72); and COX-2 inhibitors (MD -10.92; 95% CrI -12.77 to -9.08).	Morphine	63-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
20346263-15	2010	When paracetamol, NSAIDs or COX-2 inhibitors were added to PCA morphine, there was a statistically significant reduction in morphine consumption: paracetamol (MD -6.34 mg; 95% CrI -9.02 to -3.65); NSAIDs (MD -10.18; 95% CrI -11.65 to -8.72); and COX-2 inhibitors (MD -10.92; 95% CrI -12.77 to -9.08).	Morphine	124-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
19752399-8	2010	5S,15S-diHETE has been described as a product of the cross-over of 5-lipoxygenase (5-LOX) and 15-LOX activities in elicited rat mononuclear cells and human leukocytes, and our studies implicate cross-over of the 5-LOX and COX-2 pathways as an additional biosynthetic route.	5,15-dihydroxy-6,8,11,13-eicosatetraenoic acid	0-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	222-227
20121216-1	2010	The activation of N,N"-bis(3,5-di-tert-butylsalicylidene)-1,2-cyclohexane-diamino Co(II), [Co(II)(1)], by the addition of acetic acid under aerobic conditions has been investigated by a range of spectroscopic techniques including continuous-wave EPR, HYSCORE, pulsed ENDOR, and resonance Raman.	co(ii)(1)	91-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-89
20121216-1	2010	The activation of N,N"-bis(3,5-di-tert-butylsalicylidene)-1,2-cyclohexane-diamino Co(II), [Co(II)(1)], by the addition of acetic acid under aerobic conditions has been investigated by a range of spectroscopic techniques including continuous-wave EPR, HYSCORE, pulsed ENDOR, and resonance Raman.	Acetic Acid	122-133	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-89
20197018-4	2010	This case report describes our experience with Celecoxib, a COX-2 inhibitor, in a 12-year-old boy.	Celecoxib	47-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-65
19821775-8	2010	Pretreating MG63 cells with 17beta-estradiol for 6 hrs augmented the shear-induced c-fos and Cox-2 expressions.	Estradiol	28-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-98
19821775-9	2010	The augmented effects of 17beta-estradiol on shear-induced MAPK phosphorylations and c-fos and Cox-2 expressions were inhibited by pretreating the cells with ICI 182,780 or transfecting the cells with beta(1)-specific small interfering RNA.	Estradiol	25-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-100
20117851-4	2010	This suggested that selective inhibition of the synthesis of COX-2-derived prostanoids could lead to undesired disruption of the intricate inter-eicosanoid network.	Eicosanoids	145-155	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-66
20208419-8	2010	Likewise, the LPS-stimulated PGE(2) production was inhibited by the pretreatment with a specific COX2 inhibitor, NS-398, or a specific inhibitor of nuclear factor (NF)-kappaB, BAY11-7085.	Dinoprostone	29-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-101
20092265-1	2010	A Co(II)-salen based fluorescent sensor (1.Co) that can selectively recognize cyanide anions in 1:2 binding stoichiometry over other anions has been developed.	Cobalt	43-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	2-8
20092265-1	2010	A Co(II)-salen based fluorescent sensor (1.Co) that can selectively recognize cyanide anions in 1:2 binding stoichiometry over other anions has been developed.	Cyanides	78-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	2-8
20087348-0	2010	Reversal of gene expression changes in the colorectal normal-adenoma pathway by NS398 selective COX2 inhibitor.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	80-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-100
19880272-0	2010	Aspirin inhibits MMP-9 mRNA expression and release via the PPARalpha/gamma and COX-2/mPGES-1-mediated pathways in macrophages derived from THP-1 cells.	Aspirin	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-84
19880272-4	2010	Additionally, the COX-2 mRNA expression, mPGES-1 mRNA and protein expression in macrophages were all decreased after incubation with aspirin for 24h and the PGE(2) release was also decreased.	Aspirin	133-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-23
20061161-1	2010	A new group of 2,3-diarylquinoline derivatives possessing a methylsulfonyl COX-2 pharmacophore at the para-position of the C-2 phenyl ring were synthesized and evaluated as selective COX-2 inhibitors.	2,3-diarylquinoline	15-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
20061161-1	2010	A new group of 2,3-diarylquinoline derivatives possessing a methylsulfonyl COX-2 pharmacophore at the para-position of the C-2 phenyl ring were synthesized and evaluated as selective COX-2 inhibitors.	2,3-diarylquinoline	15-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	183-188
20061161-2	2010	In vitro COX-1/COX-2 structure-activity relationships were determined by varying the substituents on the C-4 quinoline ring.	quinoline	109-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-20
20061161-3	2010	Among the 2,3-diarylquinolines, 2-(4-(methylsulfonyl) phenyl)-3-phenylquinoline-4-carboxylic acid (8) exhibited the highest potency and selectivity for COX-2 inhibitory activity (COX-2 IC(50)=0.07 microM; selectivity index=687.1) that was more selective than the reference drug celecoxib (COX-2 IC(50)=0.06 microM; selectivity index=405).	2,3-diarylquinolines	10-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-157
20061161-3	2010	Among the 2,3-diarylquinolines, 2-(4-(methylsulfonyl) phenyl)-3-phenylquinoline-4-carboxylic acid (8) exhibited the highest potency and selectivity for COX-2 inhibitory activity (COX-2 IC(50)=0.07 microM; selectivity index=687.1) that was more selective than the reference drug celecoxib (COX-2 IC(50)=0.06 microM; selectivity index=405).	2,3-diarylquinolines	10-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	179-184
20061161-3	2010	Among the 2,3-diarylquinolines, 2-(4-(methylsulfonyl) phenyl)-3-phenylquinoline-4-carboxylic acid (8) exhibited the highest potency and selectivity for COX-2 inhibitory activity (COX-2 IC(50)=0.07 microM; selectivity index=687.1) that was more selective than the reference drug celecoxib (COX-2 IC(50)=0.06 microM; selectivity index=405).	2,3-diarylquinolines	10-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	179-184
20061161-3	2010	Among the 2,3-diarylquinolines, 2-(4-(methylsulfonyl) phenyl)-3-phenylquinoline-4-carboxylic acid (8) exhibited the highest potency and selectivity for COX-2 inhibitory activity (COX-2 IC(50)=0.07 microM; selectivity index=687.1) that was more selective than the reference drug celecoxib (COX-2 IC(50)=0.06 microM; selectivity index=405).	2-(4-(methylsulfonyl) phenyl)-3-phenylquinoline-4-carboxylic acid	32-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-157
20061161-3	2010	Among the 2,3-diarylquinolines, 2-(4-(methylsulfonyl) phenyl)-3-phenylquinoline-4-carboxylic acid (8) exhibited the highest potency and selectivity for COX-2 inhibitory activity (COX-2 IC(50)=0.07 microM; selectivity index=687.1) that was more selective than the reference drug celecoxib (COX-2 IC(50)=0.06 microM; selectivity index=405).	2-(4-(methylsulfonyl) phenyl)-3-phenylquinoline-4-carboxylic acid	32-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	179-184
20061161-3	2010	Among the 2,3-diarylquinolines, 2-(4-(methylsulfonyl) phenyl)-3-phenylquinoline-4-carboxylic acid (8) exhibited the highest potency and selectivity for COX-2 inhibitory activity (COX-2 IC(50)=0.07 microM; selectivity index=687.1) that was more selective than the reference drug celecoxib (COX-2 IC(50)=0.06 microM; selectivity index=405).	2-(4-(methylsulfonyl) phenyl)-3-phenylquinoline-4-carboxylic acid	32-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	179-184
20061161-3	2010	Among the 2,3-diarylquinolines, 2-(4-(methylsulfonyl) phenyl)-3-phenylquinoline-4-carboxylic acid (8) exhibited the highest potency and selectivity for COX-2 inhibitory activity (COX-2 IC(50)=0.07 microM; selectivity index=687.1) that was more selective than the reference drug celecoxib (COX-2 IC(50)=0.06 microM; selectivity index=405).	Celecoxib	278-287	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-157
20061161-4	2010	A molecular modeling study where 8 was docked in the binding site of COX-2 indicated that the p-MeSO(2) COX-2 pharmacophore group on the C-2 phenyl ring is oriented in the vicinity of the COX-2 secondary pocket (Arg(513), Phe(518) and Val(523)) and the carboxylic acid substituent can interact with Ser(530).	p-meso	94-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-74
20061161-4	2010	A molecular modeling study where 8 was docked in the binding site of COX-2 indicated that the p-MeSO(2) COX-2 pharmacophore group on the C-2 phenyl ring is oriented in the vicinity of the COX-2 secondary pocket (Arg(513), Phe(518) and Val(523)) and the carboxylic acid substituent can interact with Ser(530).	p-meso	94-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
20061161-4	2010	A molecular modeling study where 8 was docked in the binding site of COX-2 indicated that the p-MeSO(2) COX-2 pharmacophore group on the C-2 phenyl ring is oriented in the vicinity of the COX-2 secondary pocket (Arg(513), Phe(518) and Val(523)) and the carboxylic acid substituent can interact with Ser(530).	p-meso	94-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
20061161-4	2010	A molecular modeling study where 8 was docked in the binding site of COX-2 indicated that the p-MeSO(2) COX-2 pharmacophore group on the C-2 phenyl ring is oriented in the vicinity of the COX-2 secondary pocket (Arg(513), Phe(518) and Val(523)) and the carboxylic acid substituent can interact with Ser(530).	Arginine	212-215	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-74
20061161-4	2010	A molecular modeling study where 8 was docked in the binding site of COX-2 indicated that the p-MeSO(2) COX-2 pharmacophore group on the C-2 phenyl ring is oriented in the vicinity of the COX-2 secondary pocket (Arg(513), Phe(518) and Val(523)) and the carboxylic acid substituent can interact with Ser(530).	Arginine	212-215	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
20061161-4	2010	A molecular modeling study where 8 was docked in the binding site of COX-2 indicated that the p-MeSO(2) COX-2 pharmacophore group on the C-2 phenyl ring is oriented in the vicinity of the COX-2 secondary pocket (Arg(513), Phe(518) and Val(523)) and the carboxylic acid substituent can interact with Ser(530).	Arginine	212-215	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
20061161-4	2010	A molecular modeling study where 8 was docked in the binding site of COX-2 indicated that the p-MeSO(2) COX-2 pharmacophore group on the C-2 phenyl ring is oriented in the vicinity of the COX-2 secondary pocket (Arg(513), Phe(518) and Val(523)) and the carboxylic acid substituent can interact with Ser(530).	Phenylalanine	222-225	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-74
20061161-4	2010	A molecular modeling study where 8 was docked in the binding site of COX-2 indicated that the p-MeSO(2) COX-2 pharmacophore group on the C-2 phenyl ring is oriented in the vicinity of the COX-2 secondary pocket (Arg(513), Phe(518) and Val(523)) and the carboxylic acid substituent can interact with Ser(530).	Phenylalanine	222-225	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
20061161-4	2010	A molecular modeling study where 8 was docked in the binding site of COX-2 indicated that the p-MeSO(2) COX-2 pharmacophore group on the C-2 phenyl ring is oriented in the vicinity of the COX-2 secondary pocket (Arg(513), Phe(518) and Val(523)) and the carboxylic acid substituent can interact with Ser(530).	Phenylalanine	222-225	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
20061161-4	2010	A molecular modeling study where 8 was docked in the binding site of COX-2 indicated that the p-MeSO(2) COX-2 pharmacophore group on the C-2 phenyl ring is oriented in the vicinity of the COX-2 secondary pocket (Arg(513), Phe(518) and Val(523)) and the carboxylic acid substituent can interact with Ser(530).	Valine	235-238	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-74
20061161-4	2010	A molecular modeling study where 8 was docked in the binding site of COX-2 indicated that the p-MeSO(2) COX-2 pharmacophore group on the C-2 phenyl ring is oriented in the vicinity of the COX-2 secondary pocket (Arg(513), Phe(518) and Val(523)) and the carboxylic acid substituent can interact with Ser(530).	Valine	235-238	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
20061161-4	2010	A molecular modeling study where 8 was docked in the binding site of COX-2 indicated that the p-MeSO(2) COX-2 pharmacophore group on the C-2 phenyl ring is oriented in the vicinity of the COX-2 secondary pocket (Arg(513), Phe(518) and Val(523)) and the carboxylic acid substituent can interact with Ser(530).	Valine	235-238	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
20061161-4	2010	A molecular modeling study where 8 was docked in the binding site of COX-2 indicated that the p-MeSO(2) COX-2 pharmacophore group on the C-2 phenyl ring is oriented in the vicinity of the COX-2 secondary pocket (Arg(513), Phe(518) and Val(523)) and the carboxylic acid substituent can interact with Ser(530).	Carboxylic Acids	253-268	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-74
20061161-4	2010	A molecular modeling study where 8 was docked in the binding site of COX-2 indicated that the p-MeSO(2) COX-2 pharmacophore group on the C-2 phenyl ring is oriented in the vicinity of the COX-2 secondary pocket (Arg(513), Phe(518) and Val(523)) and the carboxylic acid substituent can interact with Ser(530).	Carboxylic Acids	253-268	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
20061161-4	2010	A molecular modeling study where 8 was docked in the binding site of COX-2 indicated that the p-MeSO(2) COX-2 pharmacophore group on the C-2 phenyl ring is oriented in the vicinity of the COX-2 secondary pocket (Arg(513), Phe(518) and Val(523)) and the carboxylic acid substituent can interact with Ser(530).	Carboxylic Acids	253-268	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
20061161-4	2010	A molecular modeling study where 8 was docked in the binding site of COX-2 indicated that the p-MeSO(2) COX-2 pharmacophore group on the C-2 phenyl ring is oriented in the vicinity of the COX-2 secondary pocket (Arg(513), Phe(518) and Val(523)) and the carboxylic acid substituent can interact with Ser(530).	Serine	299-302	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-74
20061161-4	2010	A molecular modeling study where 8 was docked in the binding site of COX-2 indicated that the p-MeSO(2) COX-2 pharmacophore group on the C-2 phenyl ring is oriented in the vicinity of the COX-2 secondary pocket (Arg(513), Phe(518) and Val(523)) and the carboxylic acid substituent can interact with Ser(530).	Serine	299-302	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
20061161-4	2010	A molecular modeling study where 8 was docked in the binding site of COX-2 indicated that the p-MeSO(2) COX-2 pharmacophore group on the C-2 phenyl ring is oriented in the vicinity of the COX-2 secondary pocket (Arg(513), Phe(518) and Val(523)) and the carboxylic acid substituent can interact with Ser(530).	Serine	299-302	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
20061161-5	2010	The structure activity data acquired indicate that the size and nature of the C-4 quinoline substituent are important for COX-2 inhibitory activity.	quinoline	82-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-127
19585117-10	2010	Western blotting assay revealed oroxylin A enhanced 5-FU-induced apoptosis in HepG2 cells by elevating the expressions of apoptotic-inducing proteins P53 and cleaved PARP and decreasing the expression of apoptotic-inhibitory proteins COX-2, Bcl-2, and pro-caspase3.	5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one	32-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	234-239
19585117-10	2010	Western blotting assay revealed oroxylin A enhanced 5-FU-induced apoptosis in HepG2 cells by elevating the expressions of apoptotic-inducing proteins P53 and cleaved PARP and decreasing the expression of apoptotic-inhibitory proteins COX-2, Bcl-2, and pro-caspase3.	Fluorouracil	52-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	234-239
20004565-0	2010	COX-2 expression in chondrosarcoma: a role for celecoxib treatment?	Celecoxib	47-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
20004565-12	2010	We confirmed the expression of COX-2 in 65% of chondrosarcomas, and COX-2 inhibition by celecoxib diminished cell viability in vitro.	Celecoxib	88-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-73
20063991-0	2010	The effect of a continuous regimen of drospirenone 3 mg/ethinylestradiol 30 microg on Cox-2 and Ki-67 expression in the endometrium.	drospirenone	38-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-91
20063991-0	2010	The effect of a continuous regimen of drospirenone 3 mg/ethinylestradiol 30 microg on Cox-2 and Ki-67 expression in the endometrium.	Ethinyl Estradiol	56-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-91
20063991-1	2010	OBJECTIVE: To study Cox-2 expression in relation to bleeding patterns in patients using an oral contraceptive containing 3 mg of drospirenone and 30 microg of ethinylestradiol (DRSP/EE).	drospirenone	129-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-25
20063991-1	2010	OBJECTIVE: To study Cox-2 expression in relation to bleeding patterns in patients using an oral contraceptive containing 3 mg of drospirenone and 30 microg of ethinylestradiol (DRSP/EE).	Ethinyl Estradiol	159-175	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-25
20028095-0	2010	Electrochemistry and spectroelectrochemistry of beta,beta"-fused quinoxalinoporphyrins and related extended bis-porphyrins with Co(III), Co(II), and Co(I) central metal ions.	beta,beta"-fused quinoxalinoporphyrins	48-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-143
20028095-0	2010	Electrochemistry and spectroelectrochemistry of beta,beta"-fused quinoxalinoporphyrins and related extended bis-porphyrins with Co(III), Co(II), and Co(I) central metal ions.	bis-porphyrins	108-122	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-143
20028095-5	2010	Each compound could be cycled between their Co(III), Co(II), and Co(I) forms under the application of a given oxidizing or reducing potential, although a one-electron reduction of the Co(II) quinoxalinoporphyrins led to a product with mixed Co(I) and porphyrin pi-anion radical character followed by generation of a pure Co(I) pi-anion radical species at more negative potentials.	porphyrin pi-anion radical	251-277	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	184-190
19914807-6	2010	We then explored the inhibitory effects of macelignan on UVB-induced MMP-9 and COX-2 and investigated the molecular mechanism underlying those effects.	macelignan	43-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-84
19914807-12	2010	CONCLUSION: These results suggest that macelignan protects skin keratinocytes from UVB-induced damage and inhibits MMP-9 and COX-2 expression by attenuating the activation of MAPKs and PI3K/Akt.	macelignan	39-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-130
20040740-5	2010	Interestingly, histamine synergistically activated TLR2-mediated Cox-2 expression and PGE(2) production.	Histamine	15-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-70
20040740-7	2010	Studies on the intra-cellular signaling pathways revealed that p38 activation is required for the synergistic activation of Cox-2 by TLR2 and histamine.	Histamine	142-151	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	124-129
21299081-6	2010	RESULTS: 25OHC induced COX-2 protein production with increasing the activity of COX enzyme in HUVEC without change in amount of COX-1 protein.	25ohc	9-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-28
21299081-7	2010	The induction of COX-2 or increasing in COX activity depended on concentration of 25OHC and time to exposure which seemed to be inhibited by genistein, a specific tyrosine kinase inhibitor.	25ohc	82-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22
21299081-7	2010	The induction of COX-2 or increasing in COX activity depended on concentration of 25OHC and time to exposure which seemed to be inhibited by genistein, a specific tyrosine kinase inhibitor.	Genistein	141-150	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22
19450893-0	2010	COX-2 specific inhibitors enhance the cytotoxic effects of pemetrexed in mesothelioma cell lines.	Pemetrexed	59-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
20117851-1	2010	In the 1990s, after identification of two cyclo-oxygenase (COX) isoforms catalyzing the synthesis of prostaglandins and thromboxane A(2) (TXA(2)), a new class of non-steroidal anti-inflammatory drug (NSAID) became available (COX-2 inhibitors, or COXIBs).	Prostaglandins	101-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	225-230
20117851-4	2010	This suggested that selective inhibition of the synthesis of COX-2-derived prostanoids could lead to undesired disruption of the intricate inter-eicosanoid network.	Prostaglandins	75-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-66
19931613-7	2010	The small molecule drug design approach focuses on the synthesis and biological evaluation of a novel series of sulfonanilide analogs derived from COX-2 selective inhibitors.	sulfonanilide	112-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-152
20077443-1	2010	Mixtures of polypyridine Fe(II) and Co(II) complexes are used as electron mediators in Ru-thienyltpy-sensitised solar cells (tpy=terpyridine).	tpy	97-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-42
20077443-1	2010	Mixtures of polypyridine Fe(II) and Co(II) complexes are used as electron mediators in Ru-thienyltpy-sensitised solar cells (tpy=terpyridine).	2,2':6',2''-Terpyridine	129-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-42
20077443-4	2010	The efficiency of the regeneration cascade is also critically dependent upon the ability of the Co(II) complex to intercept Fe(III) centres, as clearly indicated by chronocoulometry experiments.	ferric sulfate	124-131	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-102
19931518-3	2010	In the present study, we investigated the effects of a novel chlorogenic acid, 3-caffeoyl-4-dicaffeoylquinic acid (CDCQ), isolated from S. herbacea, on cyclooxygenase-2 (COX-2) expression in murine macrophage RAW 264.7 cells.	3-caffeoyl-4-dicaffeoylquinic acid	79-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	170-175
19931518-3	2010	In the present study, we investigated the effects of a novel chlorogenic acid, 3-caffeoyl-4-dicaffeoylquinic acid (CDCQ), isolated from S. herbacea, on cyclooxygenase-2 (COX-2) expression in murine macrophage RAW 264.7 cells.	3-caffeoyl-4-dicaffeoylquinic acid	115-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	170-175
19931518-4	2010	Phorbol 12-myristate 13-acetate (PMA) induces COX-2 expression and production of prostaglandin E(2) (PGE(2)).	Tetradecanoylphorbol Acetate	0-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
19931518-4	2010	Phorbol 12-myristate 13-acetate (PMA) induces COX-2 expression and production of prostaglandin E(2) (PGE(2)).	Tetradecanoylphorbol Acetate	33-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
19931518-5	2010	PMA-induced COX-2 protein, gene expression and PGE(2) production were significantly inhibited by CDCQ in a dose-dependent manner.	3-caffeoyl-4-dicaffeoylquinic acid	97-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-17
19931518-6	2010	Transfection of hCOX-2, as well as of deletion and mutation promoter constructs, revealed that the CCAAT/enhancer-binding protein (C/EBP) and activator protein-1 (AP-1) predominantly contributed to the effects of CDCQ.	3-caffeoyl-4-dicaffeoylquinic acid	213-217	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-22
19931518-10	2010	These findings demonstrate that CDCQ effectively attenuates COX-2 production, and enhance our understanding of the anti-inflammatory properties of CDCQ.	3-caffeoyl-4-dicaffeoylquinic acid	32-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-65
20124677-3	2010	Twisting of the central carboxamide group facilitates the Co(II) coordination in (II).	carboxamide	24-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-64
19883787-6	2010	The transfectants with antisense COX-2 showed significant decreases in the delayed synthesis of PGE(2) involving the inducible COX-2 in response to cell stimuli.	Dinoprostone	96-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-38
20126795-3	2010	By adding Co(ii) and Ni(ii) ions in acetonitrile solution, 1 : 1 and 1 : 2 metal : merocyanine complexes are formed simultaneously.	acetonitrile	36-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-16
20126795-3	2010	By adding Co(ii) and Ni(ii) ions in acetonitrile solution, 1 : 1 and 1 : 2 metal : merocyanine complexes are formed simultaneously.	acetonitrile	36-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-15
20126795-3	2010	By adding Co(ii) and Ni(ii) ions in acetonitrile solution, 1 : 1 and 1 : 2 metal : merocyanine complexes are formed simultaneously.	Metals	75-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-16
20126795-3	2010	By adding Co(ii) and Ni(ii) ions in acetonitrile solution, 1 : 1 and 1 : 2 metal : merocyanine complexes are formed simultaneously.	Metals	75-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-15
20126795-3	2010	By adding Co(ii) and Ni(ii) ions in acetonitrile solution, 1 : 1 and 1 : 2 metal : merocyanine complexes are formed simultaneously.	merocyanine	83-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-16
20126795-3	2010	By adding Co(ii) and Ni(ii) ions in acetonitrile solution, 1 : 1 and 1 : 2 metal : merocyanine complexes are formed simultaneously.	merocyanine	83-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-15
20004562-2	2010	Here, we investigated the role of different phospholipases (PL)A(2) in supplying arachidonic acid (AA) for COX-2-dependent PGE(2) generation and signaling pathways involved in activation of colon cancer cells by a physiologically relevant stimulus.	Arachidonic Acid	81-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-112
19883787-6	2010	The transfectants with antisense COX-2 showed significant decreases in the delayed synthesis of PGE(2) involving the inducible COX-2 in response to cell stimuli.	Dinoprostone	96-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	127-132
20004562-2	2010	Here, we investigated the role of different phospholipases (PL)A(2) in supplying arachidonic acid (AA) for COX-2-dependent PGE(2) generation and signaling pathways involved in activation of colon cancer cells by a physiologically relevant stimulus.	Prostaglandins E	123-126	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-112
19883787-11	2010	These results suggest that COX-2 is more preferentially involved in the generation of endogenous anti-adipogenic prostanoids during the maturation phase of adipocytes.	Prostaglandins	113-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-32
20004562-8	2010	Our results indicate that hypertonic stress activates PGE(2) generation by Caco-2 cells through a mechanism dependent on MAP kinase-regulated AA mobilization, increased cPLA(2)-alpha activity, and COX-2 induction.	Prostaglandins E	54-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	197-202
20121401-2	2010	The initial step in the biosynthesis of PGs is regulated by two distinct cyclooxygenase enzymes, cyclooxygenase-1 (COX-1) and COX-2.	Prostaglandins	40-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-131
19735721-9	2010	The underlying mechanism of cobalt toxicity is not clearly established, but our results seem to indicate that the toxicity of Co(II) and of irradiation arises from production of reactive oxygen species.	Cobalt	28-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-132
19735721-9	2010	The underlying mechanism of cobalt toxicity is not clearly established, but our results seem to indicate that the toxicity of Co(II) and of irradiation arises from production of reactive oxygen species.	Reactive Oxygen Species	178-201	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-132
20043639-5	2010	Examination of both the barriers and driving forces associated with the two pathways indicates that the homolytic reaction (Co(III)H + Co(III)H --&gt; 2 Co(II) + H(2)) is favored over the route that goes through a Co(III) intermediate (Co(III)H + H(+) --&gt; Co(III) + H(2)).	Hydrogen	162-167	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	153-159
20043639-5	2010	Examination of both the barriers and driving forces associated with the two pathways indicates that the homolytic reaction (Co(III)H + Co(III)H --&gt; 2 Co(II) + H(2)) is favored over the route that goes through a Co(III) intermediate (Co(III)H + H(+) --&gt; Co(III) + H(2)).	Hydrogen	162-166	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	153-159
20000485-0	2010	Cyanide lability and linkage isomerism of hexacyanochromate(III) induced by the Co(II) ion.	Cyanides	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-86
20000485-0	2010	Cyanide lability and linkage isomerism of hexacyanochromate(III) induced by the Co(II) ion.	hexacyanochromate	42-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-86
20000485-1	2010	Reactions between the [M(III)(CN)(6)](3-) (M = Fe and Co) anions and the mononuclear complex [Co(II)(dppe)(2)(H(2)O)][BF(4)](2) result in the formation of two isostructural trinuclear clusters {[Co(II)(dppe)(2)](2)[M(III)(CN)(6)]}(BF(4)).	co)	54-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-99
20000485-1	2010	Reactions between the [M(III)(CN)(6)](3-) (M = Fe and Co) anions and the mononuclear complex [Co(II)(dppe)(2)(H(2)O)][BF(4)](2) result in the formation of two isostructural trinuclear clusters {[Co(II)(dppe)(2)](2)[M(III)(CN)(6)]}(BF(4)).	co)	54-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-100
20000485-1	2010	Reactions between the [M(III)(CN)(6)](3-) (M = Fe and Co) anions and the mononuclear complex [Co(II)(dppe)(2)(H(2)O)][BF(4)](2) result in the formation of two isostructural trinuclear clusters {[Co(II)(dppe)(2)](2)[M(III)(CN)(6)]}(BF(4)).	dppe	101-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-99
20000485-1	2010	Reactions between the [M(III)(CN)(6)](3-) (M = Fe and Co) anions and the mononuclear complex [Co(II)(dppe)(2)(H(2)O)][BF(4)](2) result in the formation of two isostructural trinuclear clusters {[Co(II)(dppe)(2)](2)[M(III)(CN)(6)]}(BF(4)).	dppe	101-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-100
20000485-1	2010	Reactions between the [M(III)(CN)(6)](3-) (M = Fe and Co) anions and the mononuclear complex [Co(II)(dppe)(2)(H(2)O)][BF(4)](2) result in the formation of two isostructural trinuclear clusters {[Co(II)(dppe)(2)](2)[M(III)(CN)(6)]}(BF(4)).	hippuric acid	111-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-99
19682434-9	2010	Curcumin abolished the constitutive activation of NF-kappaB in the tumor tissue; induced apoptosis, and decreased cyclin D1, VEGF, COX-2, c-myc and Bcl-2 expression in the bladder cancer tissue.	Curcumin	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-136
20000485-1	2010	Reactions between the [M(III)(CN)(6)](3-) (M = Fe and Co) anions and the mononuclear complex [Co(II)(dppe)(2)(H(2)O)][BF(4)](2) result in the formation of two isostructural trinuclear clusters {[Co(II)(dppe)(2)](2)[M(III)(CN)(6)]}(BF(4)).	hippuric acid	111-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-100
20000485-1	2010	Reactions between the [M(III)(CN)(6)](3-) (M = Fe and Co) anions and the mononuclear complex [Co(II)(dppe)(2)(H(2)O)][BF(4)](2) result in the formation of two isostructural trinuclear clusters {[Co(II)(dppe)(2)](2)[M(III)(CN)(6)]}(BF(4)).	fluoroboric acid	118-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-99
20000485-1	2010	Reactions between the [M(III)(CN)(6)](3-) (M = Fe and Co) anions and the mononuclear complex [Co(II)(dppe)(2)(H(2)O)][BF(4)](2) result in the formation of two isostructural trinuclear clusters {[Co(II)(dppe)(2)](2)[M(III)(CN)(6)]}(BF(4)).	fluoroboric acid	118-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-100
20000485-1	2010	Reactions between the [M(III)(CN)(6)](3-) (M = Fe and Co) anions and the mononuclear complex [Co(II)(dppe)(2)(H(2)O)][BF(4)](2) result in the formation of two isostructural trinuclear clusters {[Co(II)(dppe)(2)](2)[M(III)(CN)(6)]}(BF(4)).	dppe	202-206	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-99
20000485-1	2010	Reactions between the [M(III)(CN)(6)](3-) (M = Fe and Co) anions and the mononuclear complex [Co(II)(dppe)(2)(H(2)O)][BF(4)](2) result in the formation of two isostructural trinuclear clusters {[Co(II)(dppe)(2)](2)[M(III)(CN)(6)]}(BF(4)).	benzo(b)fluoranthene	118-120	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-99
20000485-1	2010	Reactions between the [M(III)(CN)(6)](3-) (M = Fe and Co) anions and the mononuclear complex [Co(II)(dppe)(2)(H(2)O)][BF(4)](2) result in the formation of two isostructural trinuclear clusters {[Co(II)(dppe)(2)](2)[M(III)(CN)(6)]}(BF(4)).	benzo(b)fluoranthene	118-120	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-100
20000485-3	2010	In the former case, an unusual pentanuclear intermediate complex {[Co(II)(3)(dppe)(4)(MeCN)][Cr(III)(CN)(6)](2)} was isolated.	dppe)(4)	77-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-73
20000485-3	2010	In the former case, an unusual pentanuclear intermediate complex {[Co(II)(3)(dppe)(4)(MeCN)][Cr(III)(CN)(6)](2)} was isolated.	acetonitrile	86-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-73
20000485-3	2010	In the former case, an unusual pentanuclear intermediate complex {[Co(II)(3)(dppe)(4)(MeCN)][Cr(III)(CN)(6)](2)} was isolated.	Chromium	93-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-73
20000485-5	2010	The loss of carbon-bound CN(-) ligands from [Cr(CN)(6)](3-) occurs on a sufficiently slow time-scale for observation of varying degrees of cyanide linkage isomerism in the trigonal bipyramidal complex {[Co(tmphen)(2)](3)[Cr(CN)(6)](2)}; the study was aided by the use of different Co(II) starting materials.	Carbon	12-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	281-287
20000485-5	2010	The loss of carbon-bound CN(-) ligands from [Cr(CN)(6)](3-) occurs on a sufficiently slow time-scale for observation of varying degrees of cyanide linkage isomerism in the trigonal bipyramidal complex {[Co(tmphen)(2)](3)[Cr(CN)(6)](2)}; the study was aided by the use of different Co(II) starting materials.	Chromium	45-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	281-287
20000485-5	2010	The loss of carbon-bound CN(-) ligands from [Cr(CN)(6)](3-) occurs on a sufficiently slow time-scale for observation of varying degrees of cyanide linkage isomerism in the trigonal bipyramidal complex {[Co(tmphen)(2)](3)[Cr(CN)(6)](2)}; the study was aided by the use of different Co(II) starting materials.	cr(cn)	45-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	281-287
20000485-6	2010	Results obtained by a combination of X-ray crystallography, infrared spectroscopy, and magnetometry provide unequivocal evidence that the presence of certain Lewis acids (e.g., Co(II) in this work and Fe(II) ions and BPh(3) in previously reported studies) promote the process of cyanide linkage isomerism, which, in the case of Co(II) species, leads to facile labilization of cyanide ligands from the [Cr(CN)(6)](3-) anion.	ammonium ferrous sulfate	201-207	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	328-334
20000485-6	2010	Results obtained by a combination of X-ray crystallography, infrared spectroscopy, and magnetometry provide unequivocal evidence that the presence of certain Lewis acids (e.g., Co(II) in this work and Fe(II) ions and BPh(3) in previously reported studies) promote the process of cyanide linkage isomerism, which, in the case of Co(II) species, leads to facile labilization of cyanide ligands from the [Cr(CN)(6)](3-) anion.	Cyanides	279-286	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	177-183
20000485-6	2010	Results obtained by a combination of X-ray crystallography, infrared spectroscopy, and magnetometry provide unequivocal evidence that the presence of certain Lewis acids (e.g., Co(II) in this work and Fe(II) ions and BPh(3) in previously reported studies) promote the process of cyanide linkage isomerism, which, in the case of Co(II) species, leads to facile labilization of cyanide ligands from the [Cr(CN)(6)](3-) anion.	Cyanides	376-383	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	177-183
19748730-0	2010	Characterization of sodium dodecyl sulfate modified iron pillared montmorillonite and its application for the removal of aqueous Cu(II) and Co(II).	Sodium Dodecyl Sulfate	20-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-146
19748730-0	2010	Characterization of sodium dodecyl sulfate modified iron pillared montmorillonite and its application for the removal of aqueous Cu(II) and Co(II).	Iron	52-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-146
19783369-0	2010	Extraction and separation of Co(II) and Ni(II) from acidic sulfate solutions using Aliquat 336.	Sulfates	59-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-35
19783369-3	2010	Co(II) was preferentially extracted by different forms of Aliquat 336 over Ni(II) under the same extraction conditions.	Nickel(2+)	75-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
19954165-3	2010	The difference in M-O distances (Delta(M-O)) involving this ligand varies through the series, with the asymmetry of flavonolate coordination increasing in the order Mn(II) approximately Ni(II) &lt; Cu(II) &lt; Zn(II) &lt; Co(II).	flavonolate	116-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	222-228
21579621-1	2010	In the title compound, [Co(NO(3))(2)(C(19)H(16)N(4))], the diphenyl-dipyrazolylmethane ligand coordinates to Co(II) in a bidentate fashion forming a six-membered ring with an approximate boat configuration.	co(no(3))	24-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-115
21579621-1	2010	In the title compound, [Co(NO(3))(2)(C(19)H(16)N(4))], the diphenyl-dipyrazolylmethane ligand coordinates to Co(II) in a bidentate fashion forming a six-membered ring with an approximate boat configuration.	diphenyl(dipyrazolyl)methane	59-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-115
21579621-3	2010	The coordination at the Co(II) center is best described as distorted octa-hedral with two NO(3) (-) anions serving as bidentate ligands for charge balance.	CDTA	69-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-30
21579621-3	2010	The coordination at the Co(II) center is best described as distorted octa-hedral with two NO(3) (-) anions serving as bidentate ligands for charge balance.	hedral	74-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-30
19954165-4	2010	The hypsochromic shift of the absorption band I (pi--&gt;pi*) of the coordinated flavonolate ligand in 1-5-OTf (relative to that in free anion) increases in the order Ni(II) &lt; Mn(II) &lt; Cu(II) &lt; Zn(II), Co(II).	flavonolate	81-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	211-217
19954165-4	2010	The hypsochromic shift of the absorption band I (pi--&gt;pi*) of the coordinated flavonolate ligand in 1-5-OTf (relative to that in free anion) increases in the order Ni(II) &lt; Mn(II) &lt; Cu(II) &lt; Zn(II), Co(II).	Nickel(2+)	167-173	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	211-217
19954165-6	2010	(1)H NMR studies indicate that the 3-Hfl complexes of Co(II), Ni(II), and Zn(II) exhibit a pseudo-octahedral geometry in solution.	Zinc	74-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-60
19954165-11	2010	Under similar conditions, the 3-Hfl complexes of Co(II), Ni(II), and Cu(II) undergo flavonolate ligand exchange to produce [(6-Ph(2)TPA)M(CD(3)CN)(n)](X)(2) (M = Co, Ni, Cu; n = 1 or 2) and [Zn(3-Hfl)(2).2H(2)O].	3-hfl	30-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-55
19954165-11	2010	Under similar conditions, the 3-Hfl complexes of Co(II), Ni(II), and Cu(II) undergo flavonolate ligand exchange to produce [(6-Ph(2)TPA)M(CD(3)CN)(n)](X)(2) (M = Co, Ni, Cu; n = 1 or 2) and [Zn(3-Hfl)(2).2H(2)O].	flavonolate	84-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-55
19954165-11	2010	Under similar conditions, the 3-Hfl complexes of Co(II), Ni(II), and Cu(II) undergo flavonolate ligand exchange to produce [(6-Ph(2)TPA)M(CD(3)CN)(n)](X)(2) (M = Co, Ni, Cu; n = 1 or 2) and [Zn(3-Hfl)(2).2H(2)O].	Tetradecanoylphorbol Acetate	132-135	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-55
19954165-11	2010	Under similar conditions, the 3-Hfl complexes of Co(II), Ni(II), and Cu(II) undergo flavonolate ligand exchange to produce [(6-Ph(2)TPA)M(CD(3)CN)(n)](X)(2) (M = Co, Ni, Cu; n = 1 or 2) and [Zn(3-Hfl)(2).2H(2)O].	cd(3)cn)	138-146	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-55
19954165-11	2010	Under similar conditions, the 3-Hfl complexes of Co(II), Ni(II), and Cu(II) undergo flavonolate ligand exchange to produce [(6-Ph(2)TPA)M(CD(3)CN)(n)](X)(2) (M = Co, Ni, Cu; n = 1 or 2) and [Zn(3-Hfl)(2).2H(2)O].	Copper	69-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-55
19954165-11	2010	Under similar conditions, the 3-Hfl complexes of Co(II), Ni(II), and Cu(II) undergo flavonolate ligand exchange to produce [(6-Ph(2)TPA)M(CD(3)CN)(n)](X)(2) (M = Co, Ni, Cu; n = 1 or 2) and [Zn(3-Hfl)(2).2H(2)O].	zn(3-hfl	191-199	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-55
19954165-11	2010	Under similar conditions, the 3-Hfl complexes of Co(II), Ni(II), and Cu(II) undergo flavonolate ligand exchange to produce [(6-Ph(2)TPA)M(CD(3)CN)(n)](X)(2) (M = Co, Ni, Cu; n = 1 or 2) and [Zn(3-Hfl)(2).2H(2)O].	Deuterium	204-206	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-55
20000874-2	2010	Piroxicam is a nonselective nonsteroidal anti-inflammatory drug that blocks the activity of COX-1 and COX-2.	Piroxicam	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-107
20024194-1	2010	A novel separation mode of isotachophoresis (ITP) was advanced for the study on the continuous moving chelation boundary (MCB) formed with EDTA and two metal ions of Co(II) and Cu(II).	Metals	152-157	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	166-172
20059330-3	2010	Evidence from human pharmacology and genetics, genetically manipulated rodents, and other animal models and randomized trials indicates that this is consequent to suppression of COX-2-dependent cardioprotective prostagladins, particularly prostacyclin.	prostagladins	211-224	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	178-183
20059330-3	2010	Evidence from human pharmacology and genetics, genetically manipulated rodents, and other animal models and randomized trials indicates that this is consequent to suppression of COX-2-dependent cardioprotective prostagladins, particularly prostacyclin.	Epoprostenol	239-251	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	178-183
20648923-9	2010	Furthermore, compared to ASA and to diclofenac (Diclo, CAS 15307-79-6), the COX-1 and COX-2 mRNA expressions were influenced differently by STW 33-I and fraction E. ASA and Diclo inhibited both the COX-1 and COX-2 mRNA expressions, whereas STW 33-I and its fraction E increased the COX-1 mRNA expression.	Aspirin	165-168	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-91
20648923-9	2010	Furthermore, compared to ASA and to diclofenac (Diclo, CAS 15307-79-6), the COX-1 and COX-2 mRNA expressions were influenced differently by STW 33-I and fraction E. ASA and Diclo inhibited both the COX-1 and COX-2 mRNA expressions, whereas STW 33-I and its fraction E increased the COX-1 mRNA expression.	Aspirin	165-168	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	208-213
20648923-9	2010	Furthermore, compared to ASA and to diclofenac (Diclo, CAS 15307-79-6), the COX-1 and COX-2 mRNA expressions were influenced differently by STW 33-I and fraction E. ASA and Diclo inhibited both the COX-1 and COX-2 mRNA expressions, whereas STW 33-I and its fraction E increased the COX-1 mRNA expression.	Diclofenac	173-178	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-91
20414461-1	2010	A starch-urea-based biodegradable coordination polymer modified by transition metal Mn(II), Co(II), Ni(II), Cu(II), and Zn(II) was prepared by polycondensation of starch and urea.	Starch	2-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-97
20414461-1	2010	A starch-urea-based biodegradable coordination polymer modified by transition metal Mn(II), Co(II), Ni(II), Cu(II), and Zn(II) was prepared by polycondensation of starch and urea.	Urea	9-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-97
20414461-1	2010	A starch-urea-based biodegradable coordination polymer modified by transition metal Mn(II), Co(II), Ni(II), Cu(II), and Zn(II) was prepared by polycondensation of starch and urea.	Polymers	47-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-97
20414461-1	2010	A starch-urea-based biodegradable coordination polymer modified by transition metal Mn(II), Co(II), Ni(II), Cu(II), and Zn(II) was prepared by polycondensation of starch and urea.	Starch	163-169	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-97
20414461-1	2010	A starch-urea-based biodegradable coordination polymer modified by transition metal Mn(II), Co(II), Ni(II), Cu(II), and Zn(II) was prepared by polycondensation of starch and urea.	Urea	174-178	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-97
20414461-3	2010	The results of electronic spectra and magnetic moment measurements indicate that Mn(II), Co(II), and Ni(II) complexes show octahedral geometry, while Cu(II) and Zn(II) complexes show square planar and tetrahedral geometry, respectively.	Zinc	161-167	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-94
20606295-10	2010	COX-2 and its derived PGE(2) are important factors for bFGF-induced in vivo angiogenesis.	Prostaglandins E	22-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
21504136-5	2010	The addition of selective COX2 inhibitors Celebrex and curcumin to the culture medium resulted in a significant and comparable inhibition of PGE2 release, but did not inhibit Abeta42 secretion, and even significantly increased Abeta42 production in this cell system.	Celecoxib	42-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-30
20606295-11	2010	Resveratrol dose-dependently prevented both COX-2 induction and PGE(2) production in bFGF-stimulated fibroblasts.	Resveratrol	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-49
20606295-12	2010	These results suggest that resveratrol exerts the inhibitory effects on VEGF- and bFGF-induced angiogenesis through different mechanisms including inhibition of NO production in VEGF-stimulated endothelial cells and inhibition of COX-2 induction in bFGF-stimulated fibroblasts.	Resveratrol	27-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	230-235
20388085-4	2010	Cell death was reversed by the specific NF-kappaB inhibitor, TPCK, whereas COX-2 specific inhibitor determined an increase of cell damage in terms of apoptosis, as observed by YO-PRO immunostaining, DNA laddering analysis and caspase-3 activation.	yo-pro	176-182	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
19880272-7	2010	It might be concluded that aspirin could inhibit the MMP-9 gene expression and release through the PPARalpha/gamma and COX-2/mPGES-1-mediated pathways and the two pathways might be partly overlapped and even be interrelated.	Aspirin	27-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-124
20166930-2	2010	Traditional (first generation) NSAIDs exert antiinflammatory, analgesic, and antipyretic effects through the blockade of prostaglandin synthesis via non-selective inhibition of cyclooxygenase (COX-1 and COX-2) isozymes.	Prostaglandins	121-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	203-208
20166930-6	2010	Observation of increased cardiovascular risks in APPROVe (Adenomatous Polyp Prevention on Vioxx) study sent tremors and led to voluntary withdrawn of Vioxx (rofecoxib) by Merck from the market in September 2004 followed by Bextra (valdecoxib) in 2005 raising a question on the safety of selective COX-2 inhibitors.	rofecoxib	150-155	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	297-302
20050331-4	2010	We demonstrate that the Cox-2 selective small molecule inhibitors SC-58125 and NS-398 attenuate the production of human antibody isotypes including immunoglobulin M (IgM), IgG1, IgG2, IgG3 and IgG4.	1-((4-methylsulfonyl)phenyl)-3-trifluoromethyl-5-(4-fluorophenyl)pyrazole	66-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
20050331-4	2010	We demonstrate that the Cox-2 selective small molecule inhibitors SC-58125 and NS-398 attenuate the production of human antibody isotypes including immunoglobulin M (IgM), IgG1, IgG2, IgG3 and IgG4.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	79-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
21504136-5	2010	The addition of selective COX2 inhibitors Celebrex and curcumin to the culture medium resulted in a significant and comparable inhibition of PGE2 release, but did not inhibit Abeta42 secretion, and even significantly increased Abeta42 production in this cell system.	Curcumin	55-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-30
21504136-5	2010	The addition of selective COX2 inhibitors Celebrex and curcumin to the culture medium resulted in a significant and comparable inhibition of PGE2 release, but did not inhibit Abeta42 secretion, and even significantly increased Abeta42 production in this cell system.	Dinoprostone	141-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-30
20720307-0	2010	Prostaglandin-endoperoxide synthase genes COX1 and COX2 - novel modifiers of disease severity in cystic fibrosis patients.	Prostaglandins	0-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-55
19471853-6	2010	Also, we show that cyclooxygenase (COX)-1 and COX-2 play an important role in hypoxia-induced PGE(2) production, possibly via a mechanism involving changes in their respective activity levels under low oxygen conditions.	Prostaglandins E	94-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
20720307-4	2010	The aim of this study was to evaluate the effect of functional variants in prostaglandin-endoperoxide synthase genes (COX1 and COX2) on the severity of lung disease in CF patients.	Prostaglandins	75-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	127-131
19889638-3	2010	Application of OSS (0.5 +/- 4 dynes/cm(2)) to MG63 cells induced sustained activation of phosphatidylinositol 3-kinase (PI3K)/Akt/mTOR/p70S6K (p70S6 kinase) signaling cascades and hence cell proliferation, which was accompanied by increased expression of cyclins A and D1, cyclin-dependent protein kinases-2, -4, and -6, and bone formation-related genes (c-fos, Egr-1, and Cox-2) and decreased expression of p21(CIP1) and p27(KIP1).	OSS	15-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	373-378
20391191-1	2010	We report the synthesis of new photonuclease consisting of two Co(II)/Cu(II) complexes of macrocyclic fused quinoline.	cu(ii)	70-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-69
20352809-5	2010	Adjustment of the reaction pH resulted in the formation of additional Co(II)-containing materials with strongly contrasting structures: at lower pH in the presence of oxalic acid, the same reaction components gave a protonated molecular species, [Co(2,4-pdcH)2(OH2)2].	Oxalic Acid	167-178	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-75
20352809-5	2010	Adjustment of the reaction pH resulted in the formation of additional Co(II)-containing materials with strongly contrasting structures: at lower pH in the presence of oxalic acid, the same reaction components gave a protonated molecular species, [Co(2,4-pdcH)2(OH2)2].	co(2,4-pdch	247-258	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-75
20117988-10	2010	In cells treated with a low concentration of L-Arg, the expressions of VEGF and COX-2 were increased as compared with those in the control cells; higher concentrations of L-Arg obviously decreased the expressions of p53 and bcl-2 and increased the expression of bax.	Arginine	45-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-85
20117988-10	2010	In cells treated with a low concentration of L-Arg, the expressions of VEGF and COX-2 were increased as compared with those in the control cells; higher concentrations of L-Arg obviously decreased the expressions of p53 and bcl-2 and increased the expression of bax.	Arginine	171-176	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-85
20117988-11	2010	CONCLUSION: Low-concentration L-Arg can promote the growth of LS174 cells probably by up-regulating VEGF and COX-2 protein under the influence of NO, the metabolite of L-Arg.	Arginine	30-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-114
19841157-5	2010	Oral diclofenac inhibited platelet aggregation, cyclooxygenase-1 (COX-1), and COX-2.	Diclofenac	5-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-83
19841157-6	2010	Topical diclofenac did not inhibit platelet aggregation and inhibited COX-1 and COX-2 less than oral diclofenac.	Diclofenac	8-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-85
20390907-6	2010	Desorption studies showed that the quantitative recovery of Co (II) from the spent coir pith was achieved by using 0.5 N HCl.	Hydrochloric Acid	121-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-67
19798476-8	2010	Conversely, ESRD patients show increased formation of COX2-derived prostaglandins (p &lt; 0.05) correlated with plasma sPLA(2) (r = 0.71, p &lt; 0.05).	Prostaglandins	67-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-58
19802504-0	2010	Phase II nonrandomized study of the efficacy and safety of COX-2 inhibitor celecoxib on patients with cancer cachexia.	Celecoxib	75-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-64
19802504-3	2010	We carried out a prospective phase II clinical trial to test the safety and effectiveness of an intervention with the COX-2 inhibitor celecoxib (300 mg/day for 4 months) on key variables of cachexia (lean body mass, resting energy expenditure, serum levels of proinflammatory cytokines, and fatigue) in patients with advanced cancer at different sites.	Celecoxib	134-143	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-123
19802504-9	2010	Our results showed that the COX-2 selective inhibitor celecoxib is an effective single agent for the treatment of cancer cachexia.	Celecoxib	54-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
20358486-4	2010	Recent studies have brought two new findings: 1) the toxic form of Ab is its intra- and extracellular oligomers, rather than aggregates; 2) COX-2 activation is an early event in AD, preceding plaque formation and microglia activation.	ab	67-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-145
20391191-1	2010	We report the synthesis of new photonuclease consisting of two Co(II)/Cu(II) complexes of macrocyclic fused quinoline.	quinoline	108-117	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-69
20391191-2	2010	Metal complexes are [MLX(2)], type where M = Co(II) (5), Cu(II) (6), and X = Cl, and are well characterized by elemental analysis, Fourier transform infrared spectroscopy, (1)H-NMR and electronic spectra.	Metals	0-5	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-51
20391191-6	2010	The mechanistic pathways are found to be concentration dependent on Co(II)/Cu(II) complexes and the photoexcitation energy photoredox chemistry.	cu(ii)	75-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-74
20508724-5	2010	Importantly, PPARgamma agonist-induced COX-2 expression and PGE(2) production were partially inhibited by the PPARgamma antagonist, GW9662, indicating that both PPARgamma-dependent and -independent pathways are likely involved.	2-chloro-5-nitrobenzanilide	132-138	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-44
19879047-3	2010	Recently, however, COX-2 was shown to be also involved in the metabolism of endocannabinoids.	Endocannabinoids	76-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-24
19879047-8	2010	During established inflammation all COX inhibitors reduced release of spinal PGE(2) almost equally but only the COX-2 inhibitor prevented breakdown of 2-AG.	glyceryl 2-arachidonate	151-155	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-117
19879047-9	2010	The reversal of spinal hyperexcitability by COX-2 inhibitors was prevented or partially reversed by AM-251, an antagonist at the cannabinoid-1 receptor.	AM 251	100-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-49
19879047-10	2010	We conclude that inhibition of spinal COX-2 not only reduces PG production but also endocannabinoid breakdown and provide evidence that reversal of inflammation-evoked spinal hyperexcitability by COX-2 inhibitors is more related to endocannabinoidergic mechanisms than to inhibition of spinal PG synthesis.	Prostaglandins	61-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-43
19879047-10	2010	We conclude that inhibition of spinal COX-2 not only reduces PG production but also endocannabinoid breakdown and provide evidence that reversal of inflammation-evoked spinal hyperexcitability by COX-2 inhibitors is more related to endocannabinoidergic mechanisms than to inhibition of spinal PG synthesis.	Prostaglandins	61-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	196-201
19879047-10	2010	We conclude that inhibition of spinal COX-2 not only reduces PG production but also endocannabinoid breakdown and provide evidence that reversal of inflammation-evoked spinal hyperexcitability by COX-2 inhibitors is more related to endocannabinoidergic mechanisms than to inhibition of spinal PG synthesis.	Prostaglandins	293-295	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-43
19879047-10	2010	We conclude that inhibition of spinal COX-2 not only reduces PG production but also endocannabinoid breakdown and provide evidence that reversal of inflammation-evoked spinal hyperexcitability by COX-2 inhibitors is more related to endocannabinoidergic mechanisms than to inhibition of spinal PG synthesis.	Prostaglandins	293-295	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	196-201
20508724-6	2010	GW9662 also suppressed UVB and tert-butylhydroperoxide- (TBH-) induced PGE(2) production in PHKs and intact human epidermis and partially inhibited UVB-induced COX-2 expression in PHKs.	2-chloro-5-nitrobenzanilide	0-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	160-165
20508724-6	2010	GW9662 also suppressed UVB and tert-butylhydroperoxide- (TBH-) induced PGE(2) production in PHKs and intact human epidermis and partially inhibited UVB-induced COX-2 expression in PHKs.	tert-Butylhydroperoxide	31-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	160-165
20096163-5	2009	Herein, we give an overview about actinic keratosis focusing on treatment with the COX-2 inhibitor diclofenac 3 % gel and summarize current concepts of its antineoplastic mode of action.	Diclofenac	99-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
19860378-2	2009	Moreover, we have shown that the absence of a nitrogen atom in the spacer of the helicand ligand H(2)L(a), enables the assembly of an achiral mesohelical complex in the case of Co(II) ions.	Nitrogen	46-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	177-183
20941937-3	2010	Selective COX-2 inhibitors may tip the natural balance between prothrombotic thromboxane A2 and antithrombotic prostacyclin potentially increasing the possibility of a thrombotic cardiovascular event.	Epoprostenol	111-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
20023872-3	2009	A series of air-stable dinuclear complexes of Co(II), Mn(II) and Cu(II) containing two auxiliary acetate ligands have been prepared.	Acetates	97-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-52
20023872-4	2009	The absence of acetate in reaction mixtures containing Co(II) and Mn(II) led to mononuclear complexes, with water ligands completing the coordination spheres of the metal ions, even in the presence of large excess of the metal ions.	Acetates	15-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-61
20023872-4	2009	The absence of acetate in reaction mixtures containing Co(II) and Mn(II) led to mononuclear complexes, with water ligands completing the coordination spheres of the metal ions, even in the presence of large excess of the metal ions.	Water	108-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-61
20023872-4	2009	The absence of acetate in reaction mixtures containing Co(II) and Mn(II) led to mononuclear complexes, with water ligands completing the coordination spheres of the metal ions, even in the presence of large excess of the metal ions.	Metals	165-170	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-61
20023872-4	2009	The absence of acetate in reaction mixtures containing Co(II) and Mn(II) led to mononuclear complexes, with water ligands completing the coordination spheres of the metal ions, even in the presence of large excess of the metal ions.	Metals	221-226	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-61
20023872-5	2009	Thus, bridging acetate ligands appear to stabilise the dinuclear structures for the relatively labile Co(II) and Mn(II) ions.	Acetates	15-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-108
20023878-0	2009	Kinetics and mechanism of the Co(II)-assisted oxidation of L-ascorbic acid by dioxygen and nitrite in aqueous solution.	Ascorbic Acid	59-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-35
20023878-0	2009	Kinetics and mechanism of the Co(II)-assisted oxidation of L-ascorbic acid by dioxygen and nitrite in aqueous solution.	Oxygen	78-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-35
20023878-0	2009	Kinetics and mechanism of the Co(II)-assisted oxidation of L-ascorbic acid by dioxygen and nitrite in aqueous solution.	Nitrites	91-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-35
20023878-2	2009	The Co(II) complex activates L-ascorbic acid through an intramolecular one-electron oxidation step that involves the reduction of the octasulfophenyltetrapyrazinoporphyrazine.	Ascorbic Acid	29-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
20023878-2	2009	The Co(II) complex activates L-ascorbic acid through an intramolecular one-electron oxidation step that involves the reduction of the octasulfophenyltetrapyrazinoporphyrazine.	octasulfophenyltetrapyrazinoporphyrazine	134-174	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
19921071-0	2009	Co(II) and Cr(III) complexes of formate-formamide mixed ligands: synthesis, structures, single crystal-to-single crystal transformation and magnetic behaviour.	formate-formamide	32-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-18
19921071-5	2009	A similar reaction replacing Co(II) by Cr(III) produced a heterometallic 3D extended network Na[Cr(HCOO)(4)(HCONH(2))(2)].2H(2)O (2a) at 100 degrees C. An increase in reaction temperature to 150 degrees C produced a simple mononuclear complex Cr(HCOO)(3)(HCONH(2))(3).3H(2)O (2b).	Deuterium	122-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-35
19921071-5	2009	A similar reaction replacing Co(II) by Cr(III) produced a heterometallic 3D extended network Na[Cr(HCOO)(4)(HCONH(2))(2)].2H(2)O (2a) at 100 degrees C. An increase in reaction temperature to 150 degrees C produced a simple mononuclear complex Cr(HCOO)(3)(HCONH(2))(3).3H(2)O (2b).	cr(hcoo)	96-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-35
19918615-6	2009	Cu(II) and Pb(II) also quench the fluorescence of CdS-DAB nanocomposites, with a K(sv) = 1.9 x 10(5) M(-1) and K(sv) = 2.2 x 10(4) M(-1), respectively, and Cd(II), Zn(II), Co(II) and Ni(II) have no effect.	pb(ii)	11-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	172-178
19794144-4	2009	COX-2 expression in 18Co cells treated with BK and TNF-alpha was prevented by the B(2) BK receptor antagonist HOE-140, the preferential protein kinase C (PKC) inhibitors Ro31-8220 and GF-109203X, and Go-6976, an inhibitor of conventional PKCs and protein kinase D (PKD).	109203x	187-194	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
19794144-4	2009	COX-2 expression in 18Co cells treated with BK and TNF-alpha was prevented by the B(2) BK receptor antagonist HOE-140, the preferential protein kinase C (PKC) inhibitors Ro31-8220 and GF-109203X, and Go-6976, an inhibitor of conventional PKCs and protein kinase D (PKD).	Go 6976	200-207	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
19854050-0	2009	Lead optimization of COX-2 inhibitor nimesulide analogs to overcome aromatase inhibitor resistance in breast cancer cells.	nimesulide	37-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-26
19854050-1	2009	A series of COX-2 selective inhibitor nimesulide derivatives were synthesized.	nimesulide	38-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-17
19473192-14	2009	In addition, the expression of cyclo-oxygenase (COX)-2 and intercellular adhesion molecule (ICAM)-1 in the lamina propria was reduced in patients treated with both gliadin and budesonide compared with patients treated with gliadin alone.	Budesonide	176-186	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-54
19949916-5	2009	Its analgesic activity is linked to its anti-inflammatory effects and is related to reduction in the ex vivo production in blood of cyclo-oxygenase (COX)-1 and COX-2 derived prostanoids.	Prostaglandins	174-185	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	160-165
19949916-17	2009	(3) The multiple actions of ibuprofen in controlling inflammation combine with moderate inhibition of COX-1 and COX-2 and low residence time of the drug in the body may account for the low GI, CV and renal risks from ibuprofen, especially at OTC doses.	Ibuprofen	28-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-117
19553698-0	2009	Convergence of the 5-LOX and COX-2 pathways: heme-catalyzed cleavage of the 5S-HETE-derived di-endoperoxide into aldehyde fragments.	Heme	45-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34
19553698-0	2009	Convergence of the 5-LOX and COX-2 pathways: heme-catalyzed cleavage of the 5S-HETE-derived di-endoperoxide into aldehyde fragments.	CHEMBL3739852	76-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34
19553698-0	2009	Convergence of the 5-LOX and COX-2 pathways: heme-catalyzed cleavage of the 5S-HETE-derived di-endoperoxide into aldehyde fragments.	Hydroxyeicosatetraenoic Acids	79-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34
19553698-0	2009	Convergence of the 5-LOX and COX-2 pathways: heme-catalyzed cleavage of the 5S-HETE-derived di-endoperoxide into aldehyde fragments.	di-endoperoxide	92-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34
19553698-0	2009	Convergence of the 5-LOX and COX-2 pathways: heme-catalyzed cleavage of the 5S-HETE-derived di-endoperoxide into aldehyde fragments.	Aldehydes	113-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34
19915048-10	2009	Furthermore, PPARgamma ligands alone or combined with 9-cis-retinoic acid enhanced CpG-induced expression of Cox-2 and the plasma cell transcription factor BLIMP-1.	Alitretinoin	54-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-114
20066682-0	2009	Optimization of dispersive liquid-liquid microextraction of Co(II) and Fe(III) as their oxinate chelates and analysis by HPLC: Application for the simultaneous determination of Co(II) and Fe(III) in water samples.	ferric sulfate	188-195	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-66
20066682-2	2009	In dispersive liquid-liquid microextraction process, methanol and chloroform were used as disperser and extracting solvents, respectively, and the ligand 8-hydroxy quinoline was used as a chelating agent for the extraction of Co(II) and Fe(III).	Oxyquinoline	154-173	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	226-232
19216643-5	2009	Cell responses were recorded by measuring expression of three sets of genes: (i) cyclooxygenase 1 and 2 (COX-1, COX-2) producing prostaglandins (signaling molecules); (ii) Runx2, a transcription factor for the osteogenic lineage; and (iii) the extracellular matrix proteins osteopontin, dentin matrix protein 1, and collagen type I (COL1).	Prostaglandins	129-143	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-117
21351468-2	2009	The present study was designed to investigate whether celecoxib (selective COX-2 inhibitor) has effects on cellular retinoid sensitivity of human colon cancer cell lines and its possible mechanism.	Celecoxib	54-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
21351468-2	2009	The present study was designed to investigate whether celecoxib (selective COX-2 inhibitor) has effects on cellular retinoid sensitivity of human colon cancer cell lines and its possible mechanism.	Retinoids	116-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
21351468-7	2009	The results showed that celecoxib enhanced the inhibitory effect of ATRA in both COX-2 high-expressing HT-29 and COX-2 low-expressing SW480 cell lines.	Celecoxib	24-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-86
21351468-7	2009	The results showed that celecoxib enhanced the inhibitory effect of ATRA in both COX-2 high-expressing HT-29 and COX-2 low-expressing SW480 cell lines.	Celecoxib	24-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-118
21351468-7	2009	The results showed that celecoxib enhanced the inhibitory effect of ATRA in both COX-2 high-expressing HT-29 and COX-2 low-expressing SW480 cell lines.	Tretinoin	68-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-86
21351468-7	2009	The results showed that celecoxib enhanced the inhibitory effect of ATRA in both COX-2 high-expressing HT-29 and COX-2 low-expressing SW480 cell lines.	Tretinoin	68-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-118
21351468-12	2009	In conclusion, celecoxib increased expression of RARbeta and cellular ATRA sensitivity through COX-2-independent mechanisms, which may provide a potential strategy for combination therapy.	Celecoxib	15-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-100
20193603-5	2009	Combined treatment of beta-elemene and aclarubicin (0.10 microg/ml) enhanced the apoptotic effect and down-regulated COX-2, NF-kappaB and PGE2 expressions.	beta-elemene	22-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-122
20193603-5	2009	Combined treatment of beta-elemene and aclarubicin (0.10 microg/ml) enhanced the apoptotic effect and down-regulated COX-2, NF-kappaB and PGE2 expressions.	Aclarubicin	39-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-122
20193603-7	2009	CONCLUSION: beta-elemene enhances aclarubicin-mediated apoptotic effect, down-regulation of COX-2 and their inducing products PGE2 in HL-60 cells by suppressing activitation of NF-kappaB.	beta-elemene	12-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-97
19885460-1	2009	Pyridazine-templated dicobalt macrocycles reversibly support five oxidation states with unusually positive Co(II)/Co(I) redox couples, and are also active proton reduction electrocatalysts.	pyridazine	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-113
19885460-1	2009	Pyridazine-templated dicobalt macrocycles reversibly support five oxidation states with unusually positive Co(II)/Co(I) redox couples, and are also active proton reduction electrocatalysts.	dicobalt	21-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-113
19885532-4	2009	In compounds 1-2, Mn(II) and Co(II) ions are in octahedron coordination geometries and bridged by 2-hydroxyl(phosphono)acetate through -OH, -COO and -PO3 groups into a hybrid layer.	octahedron	48-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-35
19885532-4	2009	In compounds 1-2, Mn(II) and Co(II) ions are in octahedron coordination geometries and bridged by 2-hydroxyl(phosphono)acetate through -OH, -COO and -PO3 groups into a hybrid layer.	2-hydroxyl(phosphono)acetate	98-126	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-35
19885532-4	2009	In compounds 1-2, Mn(II) and Co(II) ions are in octahedron coordination geometries and bridged by 2-hydroxyl(phosphono)acetate through -OH, -COO and -PO3 groups into a hybrid layer.	carboxyl radical	141-144	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-35
19885532-4	2009	In compounds 1-2, Mn(II) and Co(II) ions are in octahedron coordination geometries and bridged by 2-hydroxyl(phosphono)acetate through -OH, -COO and -PO3 groups into a hybrid layer.	phosphonic acid	150-153	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-35
19885534-1	2009	Two isomorphous 3D Mn(II) and Co(II) coordination polymers with a dicarboxylate inner salt and cyanate as coligands were synthesized and structurally characterized, and their magnetic properties have been studied.	malonic acid	66-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-36
19885534-1	2009	Two isomorphous 3D Mn(II) and Co(II) coordination polymers with a dicarboxylate inner salt and cyanate as coligands were synthesized and structurally characterized, and their magnetic properties have been studied.	Salts	86-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-36
19885534-1	2009	Two isomorphous 3D Mn(II) and Co(II) coordination polymers with a dicarboxylate inner salt and cyanate as coligands were synthesized and structurally characterized, and their magnetic properties have been studied.	Cyanates	95-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-36
19859616-4	2009	The order of reactivity for the M(II)-substituted species is Pd(II) &gt; Zn(II) &gt; Co(II) &gt; Ni(II), and for M(III) and M(IV) substitution is Mn(III) approximately Ir(IV) &gt; Fe(III) &gt; Cr(III).	Zinc	73-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-91
19859616-7	2009	Formation constants for the Mn(III) and Co(II)-phosphopolyoxotungstate-alcohol species with all of the above alcohols have been evaluated in 1,2-dichloroethane at 25 degrees C and range from 19.0-3.5 M(-1).	Alcohols	109-117	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
19859616-7	2009	Formation constants for the Mn(III) and Co(II)-phosphopolyoxotungstate-alcohol species with all of the above alcohols have been evaluated in 1,2-dichloroethane at 25 degrees C and range from 19.0-3.5 M(-1).	ethylene dichloride	141-159	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
19798717-5	2009	This effect stands in contrast to Zn(II)-catalysed transesterification of HPNP in water or by the synzymes Co(II)-CD6 and Ni(II)-CD6, with which no such interference by product is observed.	Zinc	34-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-117
19576865-0	2009	Nitro-aspirin inhibits MCF-7 breast cancer cell growth: effects on COX-2 expression and Wnt/beta-catenin/TCF-4 signaling.	nitroaspirin	0-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-72
19576865-5	2009	COX-2 expression was induced by p-NO-ASA, protein kinase C inhibitors reversed this induction.	pentanal	32-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
19576865-5	2009	COX-2 expression was induced by p-NO-ASA, protein kinase C inhibitors reversed this induction.	Aspirin	37-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
19632777-0	2009	Removal of Co(II) and Ni(II) ions from contaminated water using silica gel functionalized with EDTA and/or DTPA as chelating agents.	Water	52-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-17
19632777-0	2009	Removal of Co(II) and Ni(II) ions from contaminated water using silica gel functionalized with EDTA and/or DTPA as chelating agents.	Silica Gel	64-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-17
19632777-0	2009	Removal of Co(II) and Ni(II) ions from contaminated water using silica gel functionalized with EDTA and/or DTPA as chelating agents.	Edetic Acid	95-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-17
19632777-0	2009	Removal of Co(II) and Ni(II) ions from contaminated water using silica gel functionalized with EDTA and/or DTPA as chelating agents.	Pentetic Acid	107-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-17
19632777-1	2009	In this study, the removal of Co(II) and Ni(II) ions from contaminated water was investigated using silica gel materials functionalized with both ethylenediaminetetraacetic acid (EDTA) and diethylenetriaminepentaacetic acid (DTPA).	Water	71-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-36
19632777-1	2009	In this study, the removal of Co(II) and Ni(II) ions from contaminated water was investigated using silica gel materials functionalized with both ethylenediaminetetraacetic acid (EDTA) and diethylenetriaminepentaacetic acid (DTPA).	Silica Gel	100-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-36
19632777-1	2009	In this study, the removal of Co(II) and Ni(II) ions from contaminated water was investigated using silica gel materials functionalized with both ethylenediaminetetraacetic acid (EDTA) and diethylenetriaminepentaacetic acid (DTPA).	Edetic Acid	146-177	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-36
19632777-1	2009	In this study, the removal of Co(II) and Ni(II) ions from contaminated water was investigated using silica gel materials functionalized with both ethylenediaminetetraacetic acid (EDTA) and diethylenetriaminepentaacetic acid (DTPA).	Edetic Acid	179-183	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-36
19632777-1	2009	In this study, the removal of Co(II) and Ni(II) ions from contaminated water was investigated using silica gel materials functionalized with both ethylenediaminetetraacetic acid (EDTA) and diethylenetriaminepentaacetic acid (DTPA).	Pentetic Acid	189-223	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-36
19632777-1	2009	In this study, the removal of Co(II) and Ni(II) ions from contaminated water was investigated using silica gel materials functionalized with both ethylenediaminetetraacetic acid (EDTA) and diethylenetriaminepentaacetic acid (DTPA).	Pentetic Acid	225-229	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-36
19632777-5	2009	The removal of Co(II) and Ni(II) by EDTA- and/or DTPA-modified silica gels was substantially higher than that by their unmodified form.	Edetic Acid	36-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-21
19632777-5	2009	The removal of Co(II) and Ni(II) by EDTA- and/or DTPA-modified silica gels was substantially higher than that by their unmodified form.	Pentetic Acid	49-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-21
19632777-5	2009	The removal of Co(II) and Ni(II) by EDTA- and/or DTPA-modified silica gels was substantially higher than that by their unmodified form.	Silicon Dioxide	63-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-21
19632777-6	2009	The maximum Co(II) and Ni(II) uptakes by the EDTA-modified silica gel were 20.0 and 21.6 mg/g, comparable to their adsorption capacities by DTPA-modified silica gel (Co(II): 16.1mg/g; Ni(II): 16.7 mg/g).	Edetic Acid	45-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-18
19632777-6	2009	The maximum Co(II) and Ni(II) uptakes by the EDTA-modified silica gel were 20.0 and 21.6 mg/g, comparable to their adsorption capacities by DTPA-modified silica gel (Co(II): 16.1mg/g; Ni(II): 16.7 mg/g).	Edetic Acid	45-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-17
19632777-6	2009	The maximum Co(II) and Ni(II) uptakes by the EDTA-modified silica gel were 20.0 and 21.6 mg/g, comparable to their adsorption capacities by DTPA-modified silica gel (Co(II): 16.1mg/g; Ni(II): 16.7 mg/g).	Silica Gel	59-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-18
19632777-6	2009	The maximum Co(II) and Ni(II) uptakes by the EDTA-modified silica gel were 20.0 and 21.6 mg/g, comparable to their adsorption capacities by DTPA-modified silica gel (Co(II): 16.1mg/g; Ni(II): 16.7 mg/g).	Silica Gel	59-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-17
19632777-9	2009	The kinetics of Co(II) and Ni(II) adsorption by modified silica gels followed pseudo-second-order.	Silicon Dioxide	57-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-22
19773750-6	2009	Melatonin 1 nM was able to counteract the stimulatory effect of tetradecanoyl phorbol acetate on PGE(2) production and inhibit COX-2 and COX-1 mRNA expression.	Melatonin	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	127-132
19846775-2	2009	In PGE(2) biosynthesis, cyclooxygenases (COX-1/COX-2) convert arachidonic acid to PGH(2), which can be isomerized to PGE(2) by microsomal PGE-synthase-1 (MPGES-1).	Prostaglandins E	3-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
19846775-2	2009	In PGE(2) biosynthesis, cyclooxygenases (COX-1/COX-2) convert arachidonic acid to PGH(2), which can be isomerized to PGE(2) by microsomal PGE-synthase-1 (MPGES-1).	Arachidonic Acid	62-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
19846775-2	2009	In PGE(2) biosynthesis, cyclooxygenases (COX-1/COX-2) convert arachidonic acid to PGH(2), which can be isomerized to PGE(2) by microsomal PGE-synthase-1 (MPGES-1).	GH2 protein, human	82-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
19846775-2	2009	In PGE(2) biosynthesis, cyclooxygenases (COX-1/COX-2) convert arachidonic acid to PGH(2), which can be isomerized to PGE(2) by microsomal PGE-synthase-1 (MPGES-1).	Prostaglandins E	117-120	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
19846775-2	2009	In PGE(2) biosynthesis, cyclooxygenases (COX-1/COX-2) convert arachidonic acid to PGH(2), which can be isomerized to PGE(2) by microsomal PGE-synthase-1 (MPGES-1).	Prostaglandins E	117-120	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
19846791-6	2009	The structure supports earlier suggestions that the enzyme acts to lower the reduction potential of the Co(II)/Co(I) couple by elongating the bond between the cobalt and its upper axial water ligand, effectively making the cobalt 4-coordinate, and illuminates the role of Tyr-1139 in the stabilization of this 4-coordinate state.	Cobalt	159-165	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-110
19846791-6	2009	The structure supports earlier suggestions that the enzyme acts to lower the reduction potential of the Co(II)/Co(I) couple by elongating the bond between the cobalt and its upper axial water ligand, effectively making the cobalt 4-coordinate, and illuminates the role of Tyr-1139 in the stabilization of this 4-coordinate state.	Water	186-191	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-110
19846791-6	2009	The structure supports earlier suggestions that the enzyme acts to lower the reduction potential of the Co(II)/Co(I) couple by elongating the bond between the cobalt and its upper axial water ligand, effectively making the cobalt 4-coordinate, and illuminates the role of Tyr-1139 in the stabilization of this 4-coordinate state.	Cobalt	223-229	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-110
19846791-6	2009	The structure supports earlier suggestions that the enzyme acts to lower the reduction potential of the Co(II)/Co(I) couple by elongating the bond between the cobalt and its upper axial water ligand, effectively making the cobalt 4-coordinate, and illuminates the role of Tyr-1139 in the stabilization of this 4-coordinate state.	Tyrosine	272-275	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-110
27186084-2	2009	Activation of nAChRs in Daudi cells with epibatidine abolished the pansorbin-dependent upregulation of the pro-inflammatory marker Cox-2 both at the mRNA and protein levels, indicating that the nicotinergic signaling suppresses B-cell activation.	epibatidine	41-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-136
19673886-2	2009	We evaluated the antitumor effect of irinotecan (CPT-11) treatment combined with prolonged very low-dose administration of celecoxib, a selective COX-2 inhibitor, against three human NB xenografts, TNB9, TS-N-2nu, and TS-N-5nu.	Celecoxib	123-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	146-151
19709125-2	2009	We have previously reported that kallistatin gene therapy suppressed the growth of HCC tumors by its anti-angiogenic activity, and meloxicam, a selective COX-2 inhibitor, inhibited proliferation and induced apoptosis of human HCC cells in vitro.	Meloxicam	131-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	154-159
19843689-3	2009	In ever smokers, increased levels of urinary PGE-M reflect increased COX-2 activity.	Prostaglandins E	45-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-74
19843689-12	2009	Possibly, HNSCC patients with high COX-2 activity manifested by elevated urinary PGE-M will benefit from treatment with a COX-2 inhibitor.	Prostaglandins E	81-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40
19843689-12	2009	Possibly, HNSCC patients with high COX-2 activity manifested by elevated urinary PGE-M will benefit from treatment with a COX-2 inhibitor.	Prostaglandins E	81-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-127
19775723-0	2009	Application of a peroxymonosulfate/cobalt (PMS/Co(II)) system to treat diesel-contaminated soil.	peroxymonosulfate	17-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-53
19775723-0	2009	Application of a peroxymonosulfate/cobalt (PMS/Co(II)) system to treat diesel-contaminated soil.	Cobalt	35-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-53
19918615-6	2009	Cu(II) and Pb(II) also quench the fluorescence of CdS-DAB nanocomposites, with a K(sv) = 1.9 x 10(5) M(-1) and K(sv) = 2.2 x 10(4) M(-1), respectively, and Cd(II), Zn(II), Co(II) and Ni(II) have no effect.	cu(ii)	0-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	172-178
19319551-4	2009	RESULTS: We demonstrate for the first time an activating effect of RLX for human COX-1 and COX-2 in primary myometrial and decidual cells in vitro.	Relaxin	67-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-96
19706045-9	2009	Aspirin initially caused a time-dependent decrease in COX-2 expression but subsequently, and unexpectedly, elevated the latter.	Aspirin	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-59
19706045-10	2009	Stimulation of COX-2 expression by aspirin was further enhanced following stimulation of the Wnt/beta-catenin pathway.	Aspirin	35-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-20
19706045-11	2009	Application of the COX-2 inhibitor NS-398 suppressed elevated COX-2 expression and promoted aspirin-induced apoptosis.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	35-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-24
19706045-11	2009	Application of the COX-2 inhibitor NS-398 suppressed elevated COX-2 expression and promoted aspirin-induced apoptosis.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	35-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
19706045-11	2009	Application of the COX-2 inhibitor NS-398 suppressed elevated COX-2 expression and promoted aspirin-induced apoptosis.	Aspirin	92-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-24
19682771-6	2009	On the other hand, in searching for COX-2 inhibitor, the inhibition of plasma PGE2 for the compounds were determined and four compounds were found more potent than Prednisolone.	Dinoprostone	78-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-41
19682771-6	2009	On the other hand, in searching for COX-2 inhibitor, the inhibition of plasma PGE2 for the compounds were determined and four compounds were found more potent than Prednisolone.	Prednisolone	164-176	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-41
19800127-0	2009	The impact of spermine competition on the efficacy of DNA-binding Fe(II), Co(II), and Cu(II) complexes of dimeric chromomycin A(3).	Spermine	14-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-80
19800127-0	2009	The impact of spermine competition on the efficacy of DNA-binding Fe(II), Co(II), and Cu(II) complexes of dimeric chromomycin A(3).	chromomycin a3	114-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-80
19800127-1	2009	Chromomycin (Chro) forms a 2:1 drug/metal complex through the chelation with Fe(II), Co(II), or Cu(II) ion.	Chromomycins	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-91
19800127-1	2009	Chromomycin (Chro) forms a 2:1 drug/metal complex through the chelation with Fe(II), Co(II), or Cu(II) ion.	Chromomycins	13-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-91
19800127-1	2009	Chromomycin (Chro) forms a 2:1 drug/metal complex through the chelation with Fe(II), Co(II), or Cu(II) ion.	Metals	36-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-91
19800127-2	2009	The effects of spermine on the interaction of Fe(II), Co(II), and Cu(II) complexes of dimeric Chro with DNA were studied.	Spermine	15-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-60
19800127-4	2009	However, the DNA-Co(II)(Chro)(2) complex showed extreme resistance to spermine-mediated competition for the Co(II) cation.	chro)(2)	24-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-23
19800127-4	2009	However, the DNA-Co(II)(Chro)(2) complex showed extreme resistance to spermine-mediated competition for the Co(II) cation.	chro)(2)	24-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-114
19800127-4	2009	However, the DNA-Co(II)(Chro)(2) complex showed extreme resistance to spermine-mediated competition for the Co(II) cation.	Spermine	70-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-23
19800127-4	2009	However, the DNA-Co(II)(Chro)(2) complex showed extreme resistance to spermine-mediated competition for the Co(II) cation.	Spermine	70-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-114
19800127-5	2009	According to surface plasmon resonance (SPR) experiments, a 6mM concentration of spermine completely abolished the DNA-binding activity of Fe(II)(Chro)(2) and Cu(II)(Chro)(2) and interfered with the associative binding of Co(II)(Chro)(2) complexes to DNA duplexes, but only slightly affected dissociation.	Spermine	81-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	222-228
19800127-6	2009	In DNA integrity assays, lower concentrations of spermine (1 and 2mM) promoted DNA strand cleavage by Cu(II)(Chro)(2), whereas various concentrations of spermine protected plasmid DNA from damage caused by either Co(II)(Chro)(2) or Fe(II)(Chro)(2).	Spermine	153-161	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	213-219
19775723-3	2009	Two well-known transition metals, Fe(II) and Co(II), used to activate PMS including the effect of co-existence of counter anions (Cl(-) and SO(4)(2-)) were tested and it revealed that the most effective degradation of diesel was achieved with cobalt chloride.	so(4)	140-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-51
19775723-3	2009	Two well-known transition metals, Fe(II) and Co(II), used to activate PMS including the effect of co-existence of counter anions (Cl(-) and SO(4)(2-)) were tested and it revealed that the most effective degradation of diesel was achieved with cobalt chloride.	cobaltous chloride	243-258	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-51
19775723-6	2009	Moreover, a maximum diesel degradation of 47% was achieved at a single injection of PMS/Co(II) (i.e. 500 mM/2mM).	peroxymonosulfate	84-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-94
19775723-9	2009	The degradation of diesel increased as much as 88% when PMS/Co(II) was sequentially injected.	peroxymonosulfate	56-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-66
19775723-10	2009	This indicates that PMS/Co(II) systems are applicable for remediation of soil contaminated with diesel fuel as an aspect of in situ chemical oxidation.	peroxymonosulfate	20-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-30
19918615-6	2009	Cu(II) and Pb(II) also quench the fluorescence of CdS-DAB nanocomposites, with a K(sv) = 1.9 x 10(5) M(-1) and K(sv) = 2.2 x 10(4) M(-1), respectively, and Cd(II), Zn(II), Co(II) and Ni(II) have no effect.	cds-dab	50-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	172-178
19558494-4	2009	Baicalein (a 12-LOX inhibitor) and celecoxib (a COX-2 inhibitor) significantly reduced thymidine incorporation, whereas 12-(R)-HETE and 12-(S)-HETE (12-LOX metabolites) and PGE(2) (COX-2 metabolite) significantly enhanced thymidine incorporation, suggesting a role for these enzymes in the regulation of A431 cell proliferation.	baicalein	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	181-186
19818596-1	2009	BACKGROUND: Cyclooxygenase (COX)-2 is frequently overexpressed in non-small cell lung cancer (NSCLC) and results in increased levels of prostaglandin E2 (PGE(2)), an important signalling molecule implicated in tumourigenesis.	Dinoprostone	136-152	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-34
19818596-1	2009	BACKGROUND: Cyclooxygenase (COX)-2 is frequently overexpressed in non-small cell lung cancer (NSCLC) and results in increased levels of prostaglandin E2 (PGE(2)), an important signalling molecule implicated in tumourigenesis.	Prostaglandins E	154-157	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-34
19558494-4	2009	Baicalein (a 12-LOX inhibitor) and celecoxib (a COX-2 inhibitor) significantly reduced thymidine incorporation, whereas 12-(R)-HETE and 12-(S)-HETE (12-LOX metabolites) and PGE(2) (COX-2 metabolite) significantly enhanced thymidine incorporation, suggesting a role for these enzymes in the regulation of A431 cell proliferation.	Celecoxib	35-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-53
19558494-7	2009	Further, 12-(R)-HETE, 12-(S)-HETE and PGE(2) upregulated the p-ERK and p-Akt levels, suggesting the involvement of ERK and Akt pathways in the 12-LOX- and COX-2-mediated regulation of growth in A431 cells.	12-Hydroxy-5,8,10,14-eicosatetraenoic Acid	22-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	155-160
19558494-4	2009	Baicalein (a 12-LOX inhibitor) and celecoxib (a COX-2 inhibitor) significantly reduced thymidine incorporation, whereas 12-(R)-HETE and 12-(S)-HETE (12-LOX metabolites) and PGE(2) (COX-2 metabolite) significantly enhanced thymidine incorporation, suggesting a role for these enzymes in the regulation of A431 cell proliferation.	Celecoxib	35-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	181-186
19558494-7	2009	Further, 12-(R)-HETE, 12-(S)-HETE and PGE(2) upregulated the p-ERK and p-Akt levels, suggesting the involvement of ERK and Akt pathways in the 12-LOX- and COX-2-mediated regulation of growth in A431 cells.	Prostaglandins E	38-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	155-160
19558494-4	2009	Baicalein (a 12-LOX inhibitor) and celecoxib (a COX-2 inhibitor) significantly reduced thymidine incorporation, whereas 12-(R)-HETE and 12-(S)-HETE (12-LOX metabolites) and PGE(2) (COX-2 metabolite) significantly enhanced thymidine incorporation, suggesting a role for these enzymes in the regulation of A431 cell proliferation.	Thymidine	87-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-53
19558494-7	2009	Further, 12-(R)-HETE, 12-(S)-HETE and PGE(2) upregulated the p-ERK and p-Akt levels, suggesting the involvement of ERK and Akt pathways in the 12-LOX- and COX-2-mediated regulation of growth in A431 cells.	12-Hydroxy-5,8,10,14-eicosatetraenoic Acid	9-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	155-160
19832117-1	2009	NSAIDs depress prostaglandins synthesis through inhibition of COX-1 that is involved in maintaining cell integrity and COX-2 that, although presents particularly in the kidneys, is overexpressed in response to inflammation.	Prostaglandins	15-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-124
23762013-4	2009	At pHs above 5, Phen-FMC was found to bind a variety of transition metal cations (e.g. Co(II), Ni(II), Zn(II), etc.)	1,10-phenanthroline	16-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-93
19844858-0	2009	Apricoxib, a COX-2 inhibitor for the potential treatment of pain and cancer.	apricoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
19844858-1	2009	Apricoxib (CS-706), a small-molecule, orally active, selective COX-2 inhibitor, is under development by Tragara Pharmaceuticals Inc as an analgesic and anti-inflammatory agent, and also for its anticancer potential.	apricoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-68
19844858-1	2009	Apricoxib (CS-706), a small-molecule, orally active, selective COX-2 inhibitor, is under development by Tragara Pharmaceuticals Inc as an analgesic and anti-inflammatory agent, and also for its anticancer potential.	apricoxib	11-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-68
19623659-0	2009	Curcumin sensitizes human colorectal cancer to capecitabine by modulation of cyclin D1, COX-2, MMP-9, VEGF and CXCR4 expression in an orthotopic mouse model.	Curcumin	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-93
19923064-1	2009	OBJECTIVE: To investigate the role of COX-2 inhibitor celecoxib in inhibiting the migration of human tongue squamous cell carcinoma Tca8113 cells.	Celecoxib	54-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-43
21305160-7	2009	The data show that Co(II) and Cr(III) showed the highest degree of inhibition, across the table, followed by Mn(II) and Ce(III).	Manganese(2+)	109-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-25
21305160-7	2009	The data show that Co(II) and Cr(III) showed the highest degree of inhibition, across the table, followed by Mn(II) and Ce(III).	ce(iii)	120-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-25
19923064-5	2009	CONCLUSION: COX-2 inhibitor celecoxib can inhibit Tca8113 cell migration, the mechanism of which awaits further investigation.	Celecoxib	28-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-17
19747744-1	2009	PURPOSE: To assess the feasibility and efficacy of the COX-2 inhibitor celecoxib in conjunction with preoperative chemoradiation for patients with locally advanced rectal cancer in a double blind randomized phase II study.	Celecoxib	71-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-60
19683044-6	2009	RESULTS: EtOH extract of GSL (EGS) inhibits the expression of extracellular signal-regulated kinase (ERK), one of a MAPK, nuclear transcription factors involving nuclear factor (NF)-kappaB and Activator protein (AP)-1, COX-2 and iNOS.	Ethanol	9-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	219-224
19999807-6	2009	In in vivo studies performed on animals exposed to chemical carcinogens, the chemopreventive effect was achieved exclusively after administration of experimental selective COX-2 inhibitors, but in the only human trial, supplementation of selective COX-2 inhibitor--celecoxib turned out ineffective.	Celecoxib	265-274	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	248-253
19767234-4	2009	The stoichiometry of the formed complexes was determined by three different methods: Job"s, mole ratio and slope ratio which indicate the formation of 1:2, M:L complexes for Co(II) and Cu(II) and 1:1, Ni(II):L. Beer"s law is valid in the range 0.32-7.04 microg/mL depending on the type of the metal ion.	Nickel(2+)	201-207	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	174-197
19767234-4	2009	The stoichiometry of the formed complexes was determined by three different methods: Job"s, mole ratio and slope ratio which indicate the formation of 1:2, M:L complexes for Co(II) and Cu(II) and 1:1, Ni(II):L. Beer"s law is valid in the range 0.32-7.04 microg/mL depending on the type of the metal ion.	Metals	293-298	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	174-197
19683044-6	2009	RESULTS: EtOH extract of GSL (EGS) inhibits the expression of extracellular signal-regulated kinase (ERK), one of a MAPK, nuclear transcription factors involving nuclear factor (NF)-kappaB and Activator protein (AP)-1, COX-2 and iNOS.	egs	30-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	219-224
19724275-8	2009	Regulation of COX-2 expression by NFAT was investigated using NFAT-targeted siRNA, calcineurin inhibitors cyclosporin A and FK506, in addition to COX-2 luciferase reporter vectors that selectively lacked NFAT binding sites.	Cyclosporine	106-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
19616084-3	2009	We found that alpha-Triol concentration- and time-dependently enhanced COX-2 protein expression and mRNA production followed by PGE(2) generation in human umbilical vein endothelial cells.	alpha-triol	14-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-76
19616084-7	2009	We concluded that alpha-Triol increases COX-2 mRNA and protein expression via coordination with the PI(3)K-Akt-eNOS pathway and NF-kappaB.	alpha-triol	18-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
19616084-9	2009	Our findings also suggested that alpha-Triol might contribute to the effect of induced atherosclerosis in humans through COX-2 production in endothelial cells.	alpha-triol	33-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-126
19724275-8	2009	Regulation of COX-2 expression by NFAT was investigated using NFAT-targeted siRNA, calcineurin inhibitors cyclosporin A and FK506, in addition to COX-2 luciferase reporter vectors that selectively lacked NFAT binding sites.	Tacrolimus	124-129	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
19807183-3	2009	Structural and magnetic characterization (SQUID, EPR) of the bis-pyridine adducts of (dpm)Mn(II)(py)(2), (dpm)Fe(II)(py)(2), and (dpm)Co(II)(py)(2) reveal each divalent ion to be high-spin and pseudotetrahedral in the solid state, whereas the (dpm)Ni(II)(py)(2) is low-spin and adopts a square-planar geometry.	2,2'-Dipyridyl	61-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-139
21578138-1	2009	In the salt, (NH(4))(2)[Co(CH(4)O(6)P(2))(2)(H(2)O)(2)], the methyl-ene-diphospho-nate acts as a bidentate ligand and the Co(II) ion (site symmetry ) assumes an octa-hedral CoO(6) coordination geometry.	Salts	7-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-128
21578138-1	2009	In the salt, (NH(4))(2)[Co(CH(4)O(6)P(2))(2)(H(2)O)(2)], the methyl-ene-diphospho-nate acts as a bidentate ligand and the Co(II) ion (site symmetry ) assumes an octa-hedral CoO(6) coordination geometry.	(nh(4))	13-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-128
21578138-1	2009	In the salt, (NH(4))(2)[Co(CH(4)O(6)P(2))(2)(H(2)O)(2)], the methyl-ene-diphospho-nate acts as a bidentate ligand and the Co(II) ion (site symmetry ) assumes an octa-hedral CoO(6) coordination geometry.	co(ch(4)o(6)p(2))	24-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-128
21578138-1	2009	In the salt, (NH(4))(2)[Co(CH(4)O(6)P(2))(2)(H(2)O)(2)], the methyl-ene-diphospho-nate acts as a bidentate ligand and the Co(II) ion (site symmetry ) assumes an octa-hedral CoO(6) coordination geometry.	Water	45-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-128
19807183-3	2009	Structural and magnetic characterization (SQUID, EPR) of the bis-pyridine adducts of (dpm)Mn(II)(py)(2), (dpm)Fe(II)(py)(2), and (dpm)Co(II)(py)(2) reveal each divalent ion to be high-spin and pseudotetrahedral in the solid state, whereas the (dpm)Ni(II)(py)(2) is low-spin and adopts a square-planar geometry.	ammonium ferrous sulfate	110-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-139
21578091-2	2009	The Co(II) atom (site symmetry ) exhibits a distorted trans-CoN(2)O(4) octa-hedral geometry defined by two monodentate N-bonded and two bidentate O,O"-bonded ppa anions.	ppa	158-161	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
19686724-6	2009	Both NS-398, a specific COX-2 inhibitor, and ICI 182 780, a non-selective estrogen receptor antagonist, abolished the activity of these compounds, suggesting a COX- and estrogen receptor-dependent mechanism of activity.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	5-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
19809495-8	2009	In steroidogenic cells, PGF(2alpha) secretion was stimulated by adrenocorticotropic hormone (ACTH) and correlated to ACTH-responsiveness of both COX2 and AKR1B7/B1.	Prostaglandins F	24-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-149
19791801-3	2009	In the present study, we report the synthesis and the pharmacological evaluation of pyridine analogues of nimesulide, a COX-2 preferential inhibitor.	pyridine	84-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-125
19791801-3	2009	In the present study, we report the synthesis and the pharmacological evaluation of pyridine analogues of nimesulide, a COX-2 preferential inhibitor.	nimesulide	106-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-125
19625268-6	2009	The influence of the COX-2 SNPs on the hsCRP serum concentration was assessed.	hscrp	39-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-26
21351468-0	2009	[Celecoxib increased cellular ATRA sensitivity of human colon cancer cell lines through COX-2-independent mechanisms].	Celecoxib	1-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-93
19846907-6	2009	COX-2 induction was achieved with phorbol ester.	Phorbol Esters	34-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
19638428-1	2009	Evidence points towards a pivotal role for cyclooxygenase (COX)-2 in promoting colorectal tumorigenesis through increasing prostaglandin E(2) (PGE(2)) levels.	Dinoprostone	123-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-65
19219602-0	2009	Prostaglandin synthase 2/cyclooxygenase 2 (PTGS2/COX2) 8473T&gt;C polymorphism associated with prognosis for patients with colorectal cancer treated with capecitabine and oxaliplatin.	Capecitabine	154-166	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-53
19219602-0	2009	Prostaglandin synthase 2/cyclooxygenase 2 (PTGS2/COX2) 8473T&gt;C polymorphism associated with prognosis for patients with colorectal cancer treated with capecitabine and oxaliplatin.	Oxaliplatin	171-182	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-53
19468846-1	2009	BACKGROUND: The COX2 gene (also known as PTGS2) encodes one of the essential cyclooxygenases for the prostanoid synthesis, and its expression is tightly regulated at both transcriptional and posttranscriptional levels.	Prostaglandins	101-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-20
19638428-1	2009	Evidence points towards a pivotal role for cyclooxygenase (COX)-2 in promoting colorectal tumorigenesis through increasing prostaglandin E(2) (PGE(2)) levels.	Prostaglandins E	143-146	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-65
19638428-5	2009	Here, we report that HGF/Met signalling can promote PGE(2) biogenesis in colorectal cancer cells via COX-2 up-regulation and 15-PGDH down-regulation at the protein and messenger RNA level.	Dinoprostone	52-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-106
19638428-7	2009	Notably, inhibition of Met with the small molecule inhibitor SU11274 reduced COX-2 expression and increased 15-PGDH expression in high Met-expressing cells.	((3Z)-N-(3-chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide)	61-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-82
19638428-9	2009	Furthermore, inhibition of COX-2 impeded the growth-promoting effects of HGF, suggesting that the COX-2/PGE(2) pathway is an important mediator of HGF/Met signalling.	Dinoprostone	104-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-32
19638428-9	2009	Furthermore, inhibition of COX-2 impeded the growth-promoting effects of HGF, suggesting that the COX-2/PGE(2) pathway is an important mediator of HGF/Met signalling.	Dinoprostone	104-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-103
19656660-14	2009	CONCLUSIONS: GS-HCl differentially down-regulates COX-2 and MMP-13 expression in the IL-1beta- or PMA-treated human skin fibroblasts via the p38 MAPK-independent COX-2 translational inhibition and the p38 MAPK-dependent MMP-13 transcriptional suppression, respectively.	Tetradecanoylphorbol Acetate	98-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-55
19656660-14	2009	CONCLUSIONS: GS-HCl differentially down-regulates COX-2 and MMP-13 expression in the IL-1beta- or PMA-treated human skin fibroblasts via the p38 MAPK-independent COX-2 translational inhibition and the p38 MAPK-dependent MMP-13 transcriptional suppression, respectively.	Tetradecanoylphorbol Acetate	98-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	162-167
19656660-0	2009	Differential down-regulation of COX-2 and MMP-13 in human skin fibroblasts by glucosamine-hydrochloride.	Glucosamine hydrochloride	78-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-37
19656660-2	2009	COX-2 is an enzyme to produce prostaglandins.	Prostaglandins	30-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
19656660-5	2009	OBJECTIVE: We evaluated whether GS-HCl modulates expression of COX-2 and/or MMPs by IL-1beta or PMA in human skin fibroblasts (HSF) or keratinocytes (HaCaT).	gs-hcl	32-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-68
19656660-11	2009	Of interest, treatment with GS-HCl (10mM) led to blockage of p38 MAPK activation, accumulation of 66kDa COX-2 protein variant (without affecting COX-2 mRNA expression), and transcriptional down-regulation of MMP-13 in the IL-1beta- or PMA-treated HSF cells.	gs-hcl	28-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
19656660-11	2009	Of interest, treatment with GS-HCl (10mM) led to blockage of p38 MAPK activation, accumulation of 66kDa COX-2 protein variant (without affecting COX-2 mRNA expression), and transcriptional down-regulation of MMP-13 in the IL-1beta- or PMA-treated HSF cells.	gs-hcl	28-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-150
19656660-12	2009	Distinctly, pharmacological inhibition of p38 MAPK with SB203580 was associated with transcriptional down-regulation of COX-2 and MMP-13 in the IL-1beta- or PMA-treated HSF cells.	SB 203580	56-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-125
19656660-13	2009	In addition, the GS-HCl-mediated COX-2 protein modification was observed in both endogenous and PMA-induced COX-2 in HaCaT cells.	gs-hcl	17-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-38
19641861-1	2009	Celecoxib is a selective cyclooxygenase-2-(COX-2)-inhibitor used to treat inflammation and pain and prevents colorectal cancer in patients at high doses by affecting several non-COX-2 proteins.	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	178-183
19656660-13	2009	In addition, the GS-HCl-mediated COX-2 protein modification was observed in both endogenous and PMA-induced COX-2 in HaCaT cells.	gs-hcl	17-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-113
19656660-13	2009	In addition, the GS-HCl-mediated COX-2 protein modification was observed in both endogenous and PMA-induced COX-2 in HaCaT cells.	Tetradecanoylphorbol Acetate	96-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-38
19656660-13	2009	In addition, the GS-HCl-mediated COX-2 protein modification was observed in both endogenous and PMA-induced COX-2 in HaCaT cells.	Tetradecanoylphorbol Acetate	96-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-113
19656660-14	2009	CONCLUSIONS: GS-HCl differentially down-regulates COX-2 and MMP-13 expression in the IL-1beta- or PMA-treated human skin fibroblasts via the p38 MAPK-independent COX-2 translational inhibition and the p38 MAPK-dependent MMP-13 transcriptional suppression, respectively.	gs-hcl	13-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-55
19656660-14	2009	CONCLUSIONS: GS-HCl differentially down-regulates COX-2 and MMP-13 expression in the IL-1beta- or PMA-treated human skin fibroblasts via the p38 MAPK-independent COX-2 translational inhibition and the p38 MAPK-dependent MMP-13 transcriptional suppression, respectively.	gs-hcl	13-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	162-167
19641861-1	2009	Celecoxib is a selective cyclooxygenase-2-(COX-2)-inhibitor used to treat inflammation and pain and prevents colorectal cancer in patients at high doses by affecting several non-COX-2 proteins.	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
19641861-3	2009	Therefore, we speculated that celecoxib might accumulate in human cells, which may facilitate the drug"s interaction with non-COX-2 proteins.	Celecoxib	30-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-131
19641861-6	2009	Consequently, celecoxib disturbed the plasma membrane integrity of HCT-116 cells and displayed an increased COX-2-inhibitory potency in HCA-7 cells.	Celecoxib	14-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-113
19641861-8	2009	Accumulation of celecoxib in human cells may provide a novel molecular basis for the ability of the drug to interact with non-COX-2 targets in vivo despite comparatively low plasma concentrations.	Celecoxib	16-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-131
19347867-7	2009	Enzymatic assays using different recombinant COX-2 variants showed that COX-2-(587)Arg had significantly higher activity towards arachidonic acid than COX-2-(587)Gly (13.8 +/- 3.2 U/mg vs. 11.2 +/- 2.4 U/mg; P = 0.012).	Arginine	83-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-50
19347867-7	2009	Enzymatic assays using different recombinant COX-2 variants showed that COX-2-(587)Arg had significantly higher activity towards arachidonic acid than COX-2-(587)Gly (13.8 +/- 3.2 U/mg vs. 11.2 +/- 2.4 U/mg; P = 0.012).	Arginine	83-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
19347867-7	2009	Enzymatic assays using different recombinant COX-2 variants showed that COX-2-(587)Arg had significantly higher activity towards arachidonic acid than COX-2-(587)Gly (13.8 +/- 3.2 U/mg vs. 11.2 +/- 2.4 U/mg; P = 0.012).	Arginine	83-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
19347867-7	2009	Enzymatic assays using different recombinant COX-2 variants showed that COX-2-(587)Arg had significantly higher activity towards arachidonic acid than COX-2-(587)Gly (13.8 +/- 3.2 U/mg vs. 11.2 +/- 2.4 U/mg; P = 0.012).	Arachidonic Acid	129-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-50
19347867-7	2009	Enzymatic assays using different recombinant COX-2 variants showed that COX-2-(587)Arg had significantly higher activity towards arachidonic acid than COX-2-(587)Gly (13.8 +/- 3.2 U/mg vs. 11.2 +/- 2.4 U/mg; P = 0.012).	Arachidonic Acid	129-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
19347867-7	2009	Enzymatic assays using different recombinant COX-2 variants showed that COX-2-(587)Arg had significantly higher activity towards arachidonic acid than COX-2-(587)Gly (13.8 +/- 3.2 U/mg vs. 11.2 +/- 2.4 U/mg; P = 0.012).	Arachidonic Acid	129-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
19347867-7	2009	Enzymatic assays using different recombinant COX-2 variants showed that COX-2-(587)Arg had significantly higher activity towards arachidonic acid than COX-2-(587)Gly (13.8 +/- 3.2 U/mg vs. 11.2 +/- 2.4 U/mg; P = 0.012).	Glycine	162-165	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-50
19347867-7	2009	Enzymatic assays using different recombinant COX-2 variants showed that COX-2-(587)Arg had significantly higher activity towards arachidonic acid than COX-2-(587)Gly (13.8 +/- 3.2 U/mg vs. 11.2 +/- 2.4 U/mg; P = 0.012).	Glycine	162-165	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
19347867-7	2009	Enzymatic assays using different recombinant COX-2 variants showed that COX-2-(587)Arg had significantly higher activity towards arachidonic acid than COX-2-(587)Gly (13.8 +/- 3.2 U/mg vs. 11.2 +/- 2.4 U/mg; P = 0.012).	Glycine	162-165	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
19861248-2	2009	METHODS: The recombinant plasmid of pGenesil-1-siRNA-COX-2 was constructed and transfected into CAOV-3 cells.	pgenesil	36-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-58
20052522-12	2009	It may be speculated that the induction of cox-2 in microglia may contribute to the deleterious effects of prostanoids in cerebral edema formation during the progression of oligodendrogliomas.	Prostaglandins	107-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
19796390-6	2009	BER shows synergistic effects with some existing anticancer agents such as trichostatin A (TSA, the histone deacetylase inhibitor), celecoxib (the inhibitor of COX-2), and carmofur against the growth of MDA-MB-231 cells.	Celecoxib	132-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	160-165
19861248-5	2009	RESULTS: COX-2 mRNA and protein levels were significantly reduced after pGenesil-1-siRNA-COX-2 transfection into CAOV-3 cells, which showed obvious reduction in the cell proliferation and migration.	pgenesil-1	72-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	9-14
19861248-5	2009	RESULTS: COX-2 mRNA and protein levels were significantly reduced after pGenesil-1-siRNA-COX-2 transfection into CAOV-3 cells, which showed obvious reduction in the cell proliferation and migration.	pgenesil-1	72-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-94
19580863-0	2009	Role of IL-1 beta and COX2 in silica-induced IL-6 release and loss of pneumocytes in co-cultures.	Silicon Dioxide	30-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-26
19580863-2	2009	In this study we investigated the role of IL-1 beta, TNF-alpha and COX2 in silica-induced regulation of IL-6 release and pneumocyte loss in various mono- and co-cultures of monocytes, pneumocytes and endothelial cells.	Silicon Dioxide	75-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-71
19580863-5	2009	COX2 up-regulation by silica and IL-1 beta was eliminated by IL-1 ra.	Silicon Dioxide	22-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-4
19580863-9	2009	Our findings suggest that silica-induced IL-6 release from pneumocytes is mainly mediated via IL-1 beta release from the monocytes, via both COX2-dependent and -independent pathways.	Silicon Dioxide	26-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	141-145
19406573-2	2009	The resin was used for selective separation, preconcentration and determination of Cu(II), Ni(II), Co(II), Cd(II), Pb(II), Mn(II) and Fe(III) ions in water samples by flame atomic absorption spectrometry.	Water	150-155	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-104
19762092-5	2009	This can be investigated using whole blood assays, an approach used recently to show that acetaminophen (paracetamol) is a COX-2-selective inhibitor.	Acetaminophen	90-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-128
19762092-5	2009	This can be investigated using whole blood assays, an approach used recently to show that acetaminophen (paracetamol) is a COX-2-selective inhibitor.	Acetaminophen	105-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-128
19678668-5	2009	Cyclic voltammograms of the Co(II) complexes showed the redox processes of the terpyridine, Co(II)/Co(I), and Co(III)/Co(II).	2,2':6',2''-Terpyridine	79-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-34
19788855-1	2009	Cyclooxygenases (COX-1 and COX-2) are ER-resident proteins that catalyze the committed step in prostanoid synthesis.	Prostaglandins	95-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-32
19751497-8	2009	This effect was due, in part, to a reduction in COX enzymatic activity, mainly COX-2, at lower doses of resveratrol.	Resveratrol	104-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-84
19751497-10	2009	The present work provides evidence that resveratrol reduces the formation of prostaglandins in neuroblastoma cells by reducing the enzymatic activity of inducible enzymes, such as COX-2, and not the transcription of the PG synthases, as demonstrated elsewhere.	Resveratrol	40-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	180-185
19751497-10	2009	The present work provides evidence that resveratrol reduces the formation of prostaglandins in neuroblastoma cells by reducing the enzymatic activity of inducible enzymes, such as COX-2, and not the transcription of the PG synthases, as demonstrated elsewhere.	Prostaglandins	77-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	180-185
19658385-0	2009	pH-Dependent syntheses, structural and spectroscopic characterization, and chemical transformations of aqueous Co(II)-quinate complexes: an effort to delve into the structural speciation of the binary Co(II)-quinic acid system.	Quinic Acid	208-219	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	111-117
19658385-0	2009	pH-Dependent syntheses, structural and spectroscopic characterization, and chemical transformations of aqueous Co(II)-quinate complexes: an effort to delve into the structural speciation of the binary Co(II)-quinic acid system.	Quinic Acid	208-219	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	111-116
19658385-7	2009	The lattices in 1-3 reveal the presence of mononuclear Co(II) units bound exclusively to quinate (1 and 2) or quinate and water ligands (3), thus projecting the unique chemical reactivity in each investigated system and suggesting that 3 is an intermediate in the synthetic pathway leading to 1 and 2.	Quinic Acid	89-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-61
19658385-7	2009	The lattices in 1-3 reveal the presence of mononuclear Co(II) units bound exclusively to quinate (1 and 2) or quinate and water ligands (3), thus projecting the unique chemical reactivity in each investigated system and suggesting that 3 is an intermediate in the synthetic pathway leading to 1 and 2.	Quinic Acid	110-117	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-61
19715318-0	2009	Oxalate-bridged bimetallic complexes {NH(prol)3}[MCr(ox)3] (M = Mn(II), Fe(II), Co(II); NH(prol)3(+) = tri(3-hydroxypropyl)ammonium) exhibiting coexistent ferromagnetism and proton conduction.	Oxalates	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-86
19581122-1	2009	The coordination compounds of Cr(III), Mn(II) and Co(II) metal ions derived from quinquedentate 2,6-diacetylpyridine derivative have been synthesized and characterized by using the various physicochemical studies like stoichiometric, molar conductivity and magnetic, and spectral techniques like IR, NMR, mass, UV and EPR.	tris(1,10-phenanthroline)chromium(III) chloride	30-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-56
19581122-1	2009	The coordination compounds of Cr(III), Mn(II) and Co(II) metal ions derived from quinquedentate 2,6-diacetylpyridine derivative have been synthesized and characterized by using the various physicochemical studies like stoichiometric, molar conductivity and magnetic, and spectral techniques like IR, NMR, mass, UV and EPR.	Metals	57-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-56
19581122-1	2009	The coordination compounds of Cr(III), Mn(II) and Co(II) metal ions derived from quinquedentate 2,6-diacetylpyridine derivative have been synthesized and characterized by using the various physicochemical studies like stoichiometric, molar conductivity and magnetic, and spectral techniques like IR, NMR, mass, UV and EPR.	2,6-Diacetylpyridine	96-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-56
19658385-7	2009	The lattices in 1-3 reveal the presence of mononuclear Co(II) units bound exclusively to quinate (1 and 2) or quinate and water ligands (3), thus projecting the unique chemical reactivity in each investigated system and suggesting that 3 is an intermediate in the synthetic pathway leading to 1 and 2.	Water	122-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-61
19658385-8	2009	The octahedral sites of Co(II) are occupied by oxygens, thereby reflecting the nature of interactions between the divalent metal ion and quinic acid.	Oxygen	47-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-30
19678668-6	2009	The redox waves of Co(II)/Co(I) in 2a and 2a" were slightly different from those of other complexes because of the short polymethylene chain.	polymethylene	121-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-25
19658385-8	2009	The octahedral sites of Co(II) are occupied by oxygens, thereby reflecting the nature of interactions between the divalent metal ion and quinic acid.	Metals	123-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-30
19658385-8	2009	The octahedral sites of Co(II) are occupied by oxygens, thereby reflecting the nature of interactions between the divalent metal ion and quinic acid.	Quinic Acid	137-148	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-30
19658385-9	2009	The magnetic and EPR data on 1 and 3 support the presence of a high-spin octahedral Co(II) in an oxygen environment, having a ground state with an effective spin of S = 1/2.	Oxygen	97-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-90
19467701-4	2009	BisGMA (0.1 mm) also stimulated ERK phosphorylation, PGE(2) production, COX-2 mRNA and protein expression as well as ROS production (as indicated by an increase in cellular DCF fluorescence) in dental pulp cells.	Bisphenol A-Glycidyl Methacrylate	0-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
19658385-10	2009	The significance of 3 is further reflected into the aqueous speciation of the binary Co(II)-quinic acid system, in which 3 appears as a competent participant linked to the solid state species 1.	Quinic Acid	92-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-90
19684609-9	2009	Activation of PPARgamma by rosiglitazone increases PTEN expression and decreases COX-2 expression.	Rosiglitazone	27-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-86
19684609-11	2009	Moreover, down-regulation of COX-2 is implicated in the synergistic effect of 5-FU.	Fluorouracil	78-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34
19467701-5	2009	Catalase (500 and 1000 U/ml) and U0126 (10 and 20 microm, a MEK inhibitor) effectively prevented the BisGMA-induced ERK activation, PGE(2) production and COX-2 expression.	U 0126	33-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	154-159
19467701-5	2009	Catalase (500 and 1000 U/ml) and U0126 (10 and 20 microm, a MEK inhibitor) effectively prevented the BisGMA-induced ERK activation, PGE(2) production and COX-2 expression.	Bisphenol A-Glycidyl Methacrylate	101-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	154-159
19467701-7	2009	These results suggest that BisGMA released from composite resin may potentially affect the vitality of dental pulp and induce pulpal inflammation via stimulation of ROS production, MEK/ERK1/2 activation and subsequent COX-2 gene expression and PGE(2) production.	Bisphenol A-Glycidyl Methacrylate	27-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	218-223
19769451-7	2009	Indomethacin is the best treatment, although HC could respond to other NSAIDs, such as the selective COX-2 inhibitors.	Indomethacin	0-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-106
19563267-2	2009	The common anti-inflammatory drugs (such as aspirin, ibuprofen and naproxen) all act by blocking the action of both the COX-1 and COX-2 enzymes.	Aspirin	44-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	130-135
19624532-6	2009	Correspondingly, the clinical utility of IP (prostacyclin) antagonists is assessed in relation to the cloud hanging over the long-term safety of selective COX-2 inhibitors.	ip	41-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	155-160
19624532-6	2009	Correspondingly, the clinical utility of IP (prostacyclin) antagonists is assessed in relation to the cloud hanging over the long-term safety of selective COX-2 inhibitors.	Epoprostenol	45-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	155-160
19563267-2	2009	The common anti-inflammatory drugs (such as aspirin, ibuprofen and naproxen) all act by blocking the action of both the COX-1 and COX-2 enzymes.	Ibuprofen	53-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	130-135
18926686-6	2009	Retinoic acid also repressed LPS-induced transcription of NF-kappaB target genes such as IL-6, MCP-1 and COX-2.	Tretinoin	0-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-110
19563267-2	2009	The common anti-inflammatory drugs (such as aspirin, ibuprofen and naproxen) all act by blocking the action of both the COX-1 and COX-2 enzymes.	Naproxen	67-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	130-135
19563267-6	2009	CONCLUSION: Structural analogues of the COX-2 inhibitors celecoxib and valdecoxib, and novel potential pyridazine, triazole, indole and thione derivatives emerge as promising leads for the treatment of inflammation, pain and other diseases.	Celecoxib	57-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
19563267-6	2009	CONCLUSION: Structural analogues of the COX-2 inhibitors celecoxib and valdecoxib, and novel potential pyridazine, triazole, indole and thione derivatives emerge as promising leads for the treatment of inflammation, pain and other diseases.	valdecoxib	71-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
19505840-12	2009	Ni(II) complex is the most inhibitory metal complex, followed by Cr(III) complex, parent Schiff base then Co(II) complex.	Nickel(2+)	0-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-112
20120857-2	2009	METHOD: A combination of tarceva (EGFR-selective tyrosine kinase inhibitors) with celecoxib (Cox-2 inhibitor) was studied on its effects on cell growth, cell cycle progression, apoptosis and protein expression in CNE-2 cell lines by cell growth assay, flow cytometric analysis assay and Western blotting.	Celecoxib	82-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-98
19589894-0	2009	Early response to COX-2 inhibitors as a predictor of overall response in osteoarthritis: pooled results from two identical trials comparing etoricoxib, celecoxib and placebo.	Etoricoxib	140-150	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-23
19534677-4	2009	The derived QSAR models demonstrated that the COX-2 selectivity over COX-1 is predominantly influenced by the central core -N=C- of the diaryl system.	Nitrogen	124-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
19534677-6	2009	The derived results reveal the important structural features significant for improved COX-2 inhibitory activity and selectivity of these novel aryl sulfonamides.	aryl sulfonamides	143-160	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-91
19505840-2	2009	The metal complexes of Cr(III), Mn(II), Fe(II), Fe(III), Co(II), Ni(II), Cu(II) and Zn(II) with the ligand are prepared in good yield from the reaction of the ligand with the corresponding metal salts.	Metals	4-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-63
19505840-12	2009	Ni(II) complex is the most inhibitory metal complex, followed by Cr(III) complex, parent Schiff base then Co(II) complex.	Metals	38-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-112
19505840-2	2009	The metal complexes of Cr(III), Mn(II), Fe(II), Fe(III), Co(II), Ni(II), Cu(II) and Zn(II) with the ligand are prepared in good yield from the reaction of the ligand with the corresponding metal salts.	Metals	189-194	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-63
19655070-3	2009	The crystal structure is a mixed-valence nonanuclear Co(II/III) oligomer, which contains a square-pyramidal Co(II)(5) core formed through mu(4)-Cl and mu(3)-alkoxo bridges and the pentanuclear Co(II)(5) core is surrounded by four peripheral Co(III) ions at the square-pyramidal base plane through mu(2)-alkoxo bridges.	co(ii	53-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-114
19655070-3	2009	The crystal structure is a mixed-valence nonanuclear Co(II/III) oligomer, which contains a square-pyramidal Co(II)(5) core formed through mu(4)-Cl and mu(3)-alkoxo bridges and the pentanuclear Co(II)(5) core is surrounded by four peripheral Co(III) ions at the square-pyramidal base plane through mu(2)-alkoxo bridges.	co(ii	53-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	193-199
19655070-3	2009	The crystal structure is a mixed-valence nonanuclear Co(II/III) oligomer, which contains a square-pyramidal Co(II)(5) core formed through mu(4)-Cl and mu(3)-alkoxo bridges and the pentanuclear Co(II)(5) core is surrounded by four peripheral Co(III) ions at the square-pyramidal base plane through mu(2)-alkoxo bridges.	mu(4)-cl	138-146	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-114
19591491-7	2009	Theoretical discussion reveals that DeltaG0ads and DeltaG0chelation for the Ni(II) and Co(II) ions in the Ddien-Ni(II) and Ddien-Co(II) systems are more negative than those for Cu(II) in the Ddien-Cu(II) system.	Nickel(2+)	76-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-93
19591491-7	2009	Theoretical discussion reveals that DeltaG0ads and DeltaG0chelation for the Ni(II) and Co(II) ions in the Ddien-Ni(II) and Ddien-Co(II) systems are more negative than those for Cu(II) in the Ddien-Cu(II) system.	ddien	106-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-135
19706164-3	2009	The role of p53 mutation in the anti-tumour responses of the selective COX-2 inhibitor celecoxib in human glioblastoma cells is unknown.	Celecoxib	87-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-76
19591491-7	2009	Theoretical discussion reveals that DeltaG0ads and DeltaG0chelation for the Ni(II) and Co(II) ions in the Ddien-Ni(II) and Ddien-Co(II) systems are more negative than those for Cu(II) in the Ddien-Cu(II) system.	Nickel(2+)	76-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-135
19624164-5	2009	This analysis demonstrated that the formed carboxylate intermediate helped to stabilize the active Co(III) species against decomposition to inactive Co(II) by reversibly intramolecular Co-O bond formation and dissociation.	carboxylate	43-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	149-155
19591491-7	2009	Theoretical discussion reveals that DeltaG0ads and DeltaG0chelation for the Ni(II) and Co(II) ions in the Ddien-Ni(II) and Ddien-Co(II) systems are more negative than those for Cu(II) in the Ddien-Cu(II) system.	cu(ii)	177-183	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-93
19591491-7	2009	Theoretical discussion reveals that DeltaG0ads and DeltaG0chelation for the Ni(II) and Co(II) ions in the Ddien-Ni(II) and Ddien-Co(II) systems are more negative than those for Cu(II) in the Ddien-Cu(II) system.	cu(ii)	177-183	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-135
19624164-5	2009	This analysis demonstrated that the formed carboxylate intermediate helped to stabilize the active Co(III) species against decomposition to inactive Co(II) by reversibly intramolecular Co-O bond formation and dissociation.	co(iii)	99-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	149-155
19591491-7	2009	Theoretical discussion reveals that DeltaG0ads and DeltaG0chelation for the Ni(II) and Co(II) ions in the Ddien-Ni(II) and Ddien-Co(II) systems are more negative than those for Cu(II) in the Ddien-Cu(II) system.	ddien	123-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-93
19591491-7	2009	Theoretical discussion reveals that DeltaG0ads and DeltaG0chelation for the Ni(II) and Co(II) ions in the Ddien-Ni(II) and Ddien-Co(II) systems are more negative than those for Cu(II) in the Ddien-Cu(II) system.	ddien-ni(ii)	106-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-93
19591491-7	2009	Theoretical discussion reveals that DeltaG0ads and DeltaG0chelation for the Ni(II) and Co(II) ions in the Ddien-Ni(II) and Ddien-Co(II) systems are more negative than those for Cu(II) in the Ddien-Cu(II) system.	ddien	123-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-135
19591491-7	2009	Theoretical discussion reveals that DeltaG0ads and DeltaG0chelation for the Ni(II) and Co(II) ions in the Ddien-Ni(II) and Ddien-Co(II) systems are more negative than those for Cu(II) in the Ddien-Cu(II) system.	cu(ii)	197-203	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-93
19591491-7	2009	Theoretical discussion reveals that DeltaG0ads and DeltaG0chelation for the Ni(II) and Co(II) ions in the Ddien-Ni(II) and Ddien-Co(II) systems are more negative than those for Cu(II) in the Ddien-Cu(II) system.	cu(ii)	197-203	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-135
19624164-5	2009	This analysis demonstrated that the formed carboxylate intermediate helped to stabilize the active Co(III) species against decomposition to inactive Co(II) by reversibly intramolecular Co-O bond formation and dissociation.	carboxyl radical	185-189	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	149-155
19591491-7	2009	Theoretical discussion reveals that DeltaG0ads and DeltaG0chelation for the Ni(II) and Co(II) ions in the Ddien-Ni(II) and Ddien-Co(II) systems are more negative than those for Cu(II) in the Ddien-Cu(II) system.	ddien-ni(ii)	106-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-135
19591491-7	2009	Theoretical discussion reveals that DeltaG0ads and DeltaG0chelation for the Ni(II) and Co(II) ions in the Ddien-Ni(II) and Ddien-Co(II) systems are more negative than those for Cu(II) in the Ddien-Cu(II) system.	ddien	106-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-93
21577427-1	2009	In the title mononuclear complex, [Co(C(12)H(17)N(2)OS(2))(2)], the Co(II) atom is four-coordinated by two N,O-bidentate Schiff base ligands, resulting in a slightly distorted trans-CoN(2)O(2) square-planar coordination.	co(c(12)h(17)n(2)os(2))(2)	35-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-74
21577427-1	2009	In the title mononuclear complex, [Co(C(12)H(17)N(2)OS(2))(2)], the Co(II) atom is four-coordinated by two N,O-bidentate Schiff base ligands, resulting in a slightly distorted trans-CoN(2)O(2) square-planar coordination.	Schiff Bases	121-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-74
21577427-1	2009	In the title mononuclear complex, [Co(C(12)H(17)N(2)OS(2))(2)], the Co(II) atom is four-coordinated by two N,O-bidentate Schiff base ligands, resulting in a slightly distorted trans-CoN(2)O(2) square-planar coordination.	trans-con(2)o	176-189	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-74
19680014-3	2009	Inhibition of cyclooxygenase (COX)-1 and COX-2 by aspirin or its related compounds, nonsteroidal antiinflammatory drugs (NSAIDs), has been associated with both adverse and beneficial effects in the gastrointestinal (GI) tract.	Aspirin	50-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-46
19591466-10	2009	For the pyrazolyl 3H proton, the data indicate a 0.2 MHz anisotropic contact interaction and approximately 4% transfer of spin away from Co(II).	pyrazolyl 3h	8-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-143
19722689-8	2009	While well recognized in Cu(II) systems, this is one of the few times this approach has been used for Co(II).	cu(ii)	25-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-108
19652294-2	2009	The Co(II) ions have local 4/m symmetry, with the equatorial water molecules in the mirror plane, while the V and apical O atom of the vanadyl group are located on the fourfold rotation axis and the P atoms reside on 4 sites.	Water	61-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
19652306-6	2009	The title compound is the first example of four alkyl isocyanide ligands coordinating Co(II) upon initial reaction of Co(ClO4)(2).6H2O/EtOH with alkyl isocyanide.	alkyl isocyanide	48-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-92
19652306-6	2009	The title compound is the first example of four alkyl isocyanide ligands coordinating Co(II) upon initial reaction of Co(ClO4)(2).6H2O/EtOH with alkyl isocyanide.	co(clo4)(2).6h2o	118-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-92
19652306-6	2009	The title compound is the first example of four alkyl isocyanide ligands coordinating Co(II) upon initial reaction of Co(ClO4)(2).6H2O/EtOH with alkyl isocyanide.	Ethanol	135-139	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-92
19652306-6	2009	The title compound is the first example of four alkyl isocyanide ligands coordinating Co(II) upon initial reaction of Co(ClO4)(2).6H2O/EtOH with alkyl isocyanide.	alkyl isocyanide	145-161	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-92
19680014-11	2009	Inhibition of COX-2 by NSAIDs, coxibs, or aspirin seems to provide beneficial effects to the GI tract.	Aspirin	42-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
19571664-7	2009	The Cox-2 promoter-directed HSV-tk/ganciclovir (GCV) system mediated by adenovirus (Ad-Cp-TK) was developed (Ad-CMVp-TK, Ad-null and no Ad as controls).	Ganciclovir	35-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
18677626-0	2009	Dynamic compression inhibits fibronectin fragment induced iNOS and COX-2 expression in chondrocyte/agarose constructs.	Sepharose	99-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-72
18677626-2	2009	This study examined the combined effects of dynamic compression and the NH(2)-hep I or COOH-hep II FN-fs on the expression levels of iNOS and COX-2 and production of *NO and PGE(2) release.	Carbonic Acid	87-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	142-147
19723044-2	2009	Immunohistochemical analysis with COX-2 antibody was performed on 148 paraffin-embedded tissue specimens of patients who were diagnosed as CIN in our institute.	Paraffin	70-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-39
19571664-7	2009	The Cox-2 promoter-directed HSV-tk/ganciclovir (GCV) system mediated by adenovirus (Ad-Cp-TK) was developed (Ad-CMVp-TK, Ad-null and no Ad as controls).	Ganciclovir	48-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
19415476-4	2009	The results indicated that CTB glycoprotein decreased gene expression of cytokines of IL-4, IFN-gamma, interleukin (IL)-1beta and cyclooxygenase (COX)-2 in BPA-stimulated HMC-1 cells.	bisphenol A	156-159	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	146-152
19885014-0	2009	DHA and EPA Down-regulate COX-2 Expression through Suppression of NF-kappaB Activity in LPS-treated Human Umbilical Vein Endothelial Cells.	Docosahexaenoic Acids	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-31
19769252-1	2009	OBJECTIVE: To observe whether Celecoxib could inhibit the growth, regulate the expression of COX-2 and induce apoptosis of Tca8113 cells.	Celecoxib	30-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-98
19769252-3	2009	The expression of COX-2 protein and mRNA in Tca8113 cells was detected with SP immunohistochemistry staining and fluorescent quantitative real-time RT-PCR.	TFF2 protein, human	76-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-23
19769252-5	2009	RESULTS: COX-2 protein was strongly expressed in Tca8113 cells and was suppressed by Celecoxib.	Celecoxib	85-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	9-14
19769252-9	2009	CONCLUSION: Celecoxib shows a significant effect on inhibiting expression of COX-2 in Tca8113 cells, this is probably related to growth inhibition and inducing apoptosis of Tca8113 cells.	Celecoxib	12-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-82
19602986-2	2009	Nonsteroidal anti-inflammatory drugs selective for COX-2 were developed to inhibit the major enzymatic source of the prostaglandins that mediate pain and inflammation while sparing COX-1-derived prostaglandins that contribute dominantly to gastric cytoprotection.	Prostaglandins	117-131	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-56
19602986-2	2009	Nonsteroidal anti-inflammatory drugs selective for COX-2 were developed to inhibit the major enzymatic source of the prostaglandins that mediate pain and inflammation while sparing COX-1-derived prostaglandins that contribute dominantly to gastric cytoprotection.	Prostaglandins	195-209	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-56
19602986-4	2009	The hazard might also extend to traditional NSAIDs, which are relatively selective for COX-2, such as diclofenac, meloxicam, and etodolac.	Diclofenac	102-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-92
19602986-4	2009	The hazard might also extend to traditional NSAIDs, which are relatively selective for COX-2, such as diclofenac, meloxicam, and etodolac.	Meloxicam	114-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-92
19885014-5	2009	Results showed that EPA, DHA, or troglitazone significantly reduced COX-2 expression, NF-kappaB luciferase activity, and PGE(2) and IL-6 production in a dose-dependent fashion.	Eicosapentaenoic Acid	20-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-73
19885014-5	2009	Results showed that EPA, DHA, or troglitazone significantly reduced COX-2 expression, NF-kappaB luciferase activity, and PGE(2) and IL-6 production in a dose-dependent fashion.	Docosahexaenoic Acids	25-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-73
19885014-5	2009	Results showed that EPA, DHA, or troglitazone significantly reduced COX-2 expression, NF-kappaB luciferase activity, and PGE(2) and IL-6 production in a dose-dependent fashion.	Troglitazone	33-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-73
19885014-0	2009	DHA and EPA Down-regulate COX-2 Expression through Suppression of NF-kappaB Activity in LPS-treated Human Umbilical Vein Endothelial Cells.	Eicosapentaenoic Acid	8-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-31
18805045-5	2009	Also, we observed that SFN inhibited COX-2 but not COX-1.	sulforaphane	23-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-42
19578771-1	2009	Valdecoxib is a second generation selective COX-2 inhibitor that can induce cell apoptosis in a variety of cell types, but its precise regulatory mechanism is unknown.	valdecoxib	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-49
19671757-3	2009	Curcumin, a polyphenolic beta-diketone from tumeric with anti-carcinogenic and anti-inflammatory activities, was shown to suppress PGE(2) formation and to block the expression of COX-2 and of microsomal PGE(2) synthase-1.	Curcumin	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	179-184
19557821-3	2009	Our results show that all flavonoids significantly inhibited HG-induced expression of proinflammatory genes and proteins, including TNF-alpha, interleukin-1beta (IL-1beta), and cyclooxygenase (COX)-2, at a concentration of 20 microM.	Flavonoids	26-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	177-199
18805045-8	2009	These results show that SFN can act as a potent anti-oral cancer compound by inhibiting COX-2 activity.	sulforaphane	24-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-93
19734595-12	2009	CONCLUSION: The multimodal use of the specific COX-2 inhibitor celecoxib in the postoperative period of orthopaedic procedures clearly improves postoperative pain, reduces the opioid consumption, releases the sleep disturbance, demonstrates more satisfaction in patients and lower chronic pain rate after discharge, without affecting the platelet and coagulation function.	Celecoxib	63-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
19157703-0	2009	Co(II) removal by magnetic alginate beads containing Cyanex 272.	Alginates	27-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
19635408-6	2009	We identified novel mechanisms for existing drugs, confirmed previously reported calcium modulating activity for COX-2 inhibitor celecoxib, and identified an additional mechanism for the experimental compound monastrol.	Calcium	81-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-118
19635408-6	2009	We identified novel mechanisms for existing drugs, confirmed previously reported calcium modulating activity for COX-2 inhibitor celecoxib, and identified an additional mechanism for the experimental compound monastrol.	Celecoxib	129-138	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-118
19157703-0	2009	Co(II) removal by magnetic alginate beads containing Cyanex 272.	cyanex	53-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
19634927-1	2009	Etoricoxib is a selective cyclo-oxygenase (COX)-2 inhibitor, approved in Europe for the symptomatic treatment of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis and acute gouty arthritis.	Etoricoxib	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-49
19157703-1	2009	In this study, a series of batch experiments is conducted to investigate the ability of magnetic alginate beads containing Cyanex 272 to remove Co(II) ions from aqueous solutions.	Alginates	97-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	144-150
19157703-1	2009	In this study, a series of batch experiments is conducted to investigate the ability of magnetic alginate beads containing Cyanex 272 to remove Co(II) ions from aqueous solutions.	cyanex	123-129	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	144-150
19534545-7	2009	Reaction of [Et(4)N][LCo(III)], 2, with elemental iodine produced [L(DeltaDelta)Co(II)-I](I(3))(I(2)), 3.	Iodine	50-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-86
19585042-1	2009	A Co(II)-based catalytic system has been developed for asymmetric aziridination of alkenes with trichloroethoxysulfonyl azide (TcesN3) under mild conditions, forming the corresponding N-Tces-aziridines in high yields and excellent enantioselectivities.	Alkenes	83-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	2-7
19585042-1	2009	A Co(II)-based catalytic system has been developed for asymmetric aziridination of alkenes with trichloroethoxysulfonyl azide (TcesN3) under mild conditions, forming the corresponding N-Tces-aziridines in high yields and excellent enantioselectivities.	trichloroethoxysulfonyl azide	96-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	2-7
19534545-8	2009	This reaction is viewed as an iodine-induced electron transfer reaction across Co(III)-porphyrinogen, in which the four electrons that originated from the oxidation of the internal reductant (porphyrinogen) to porphodimethene are shared by the internal oxidant (Co(III)), and the external oxidant (iodine), resulting in the reduction to Co(II) and iodide, respectively.	Iodine	30-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	337-343
19534545-8	2009	This reaction is viewed as an iodine-induced electron transfer reaction across Co(III)-porphyrinogen, in which the four electrons that originated from the oxidation of the internal reductant (porphyrinogen) to porphodimethene are shared by the internal oxidant (Co(III)), and the external oxidant (iodine), resulting in the reduction to Co(II) and iodide, respectively.	porphodimethene	210-225	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	337-343
19500994-7	2009	These studies indicate hybrid ester AI/NO donor prodrugs of this type (NONO-coxibs) constitute a plausible drug design concept targeted toward the development of selective COX-2 inhibitory AI drugs that are devoid of adverse cardiovascular effects.	Esters	30-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	172-177
19464432-2	2009	COX-1 is a constitutive enzyme while the expression of COX-2 is highly stimulated in the event of inflammatory processes, leading to the production of large amounts of prostaglandins (PGs), in particular PGE(2) and PGI(2), which are pro-inflammatory mediators.	Prostaglandins	168-182	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-60
19464432-2	2009	COX-1 is a constitutive enzyme while the expression of COX-2 is highly stimulated in the event of inflammatory processes, leading to the production of large amounts of prostaglandins (PGs), in particular PGE(2) and PGI(2), which are pro-inflammatory mediators.	Prostaglandins	184-187	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-60
19560931-1	2009	A group of 4-carboxyl quinoline derivatives possessing a methylsulfonyl COX-2 pharmacophore at the para position of the C-2 phenyl ring were designed and synthesized as selective COX-2 inhibitors.	4-carboxyl quinoline	11-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
19464432-2	2009	COX-1 is a constitutive enzyme while the expression of COX-2 is highly stimulated in the event of inflammatory processes, leading to the production of large amounts of prostaglandins (PGs), in particular PGE(2) and PGI(2), which are pro-inflammatory mediators.	Prostaglandins E	204-207	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-60
19464432-2	2009	COX-1 is a constitutive enzyme while the expression of COX-2 is highly stimulated in the event of inflammatory processes, leading to the production of large amounts of prostaglandins (PGs), in particular PGE(2) and PGI(2), which are pro-inflammatory mediators.	Prostaglandins I	215-218	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-60
19464432-5	2009	The aim of the present work was to evaluate the anti-inflammatory potential of 2-styrylchromones (2-SC), a chemical family of oxygen heterocyclic compounds, vinylogues of flavones (2-phenylchromones), by studying their COX-1 and COX-2 inhibitory capacity as well as their effects on the LTB(4) production by stimulated human polymorphonuclear leukocytes (PMNL).	2-styrylchromone	79-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	229-234
19464432-5	2009	The aim of the present work was to evaluate the anti-inflammatory potential of 2-styrylchromones (2-SC), a chemical family of oxygen heterocyclic compounds, vinylogues of flavones (2-phenylchromones), by studying their COX-1 and COX-2 inhibitory capacity as well as their effects on the LTB(4) production by stimulated human polymorphonuclear leukocytes (PMNL).	2-styrylchromone	98-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	229-234
19464432-5	2009	The aim of the present work was to evaluate the anti-inflammatory potential of 2-styrylchromones (2-SC), a chemical family of oxygen heterocyclic compounds, vinylogues of flavones (2-phenylchromones), by studying their COX-1 and COX-2 inhibitory capacity as well as their effects on the LTB(4) production by stimulated human polymorphonuclear leukocytes (PMNL).	Flavones	171-179	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	229-234
19560931-1	2009	A group of 4-carboxyl quinoline derivatives possessing a methylsulfonyl COX-2 pharmacophore at the para position of the C-2 phenyl ring were designed and synthesized as selective COX-2 inhibitors.	4-carboxyl quinoline	11-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	179-184
19560931-1	2009	A group of 4-carboxyl quinoline derivatives possessing a methylsulfonyl COX-2 pharmacophore at the para position of the C-2 phenyl ring were designed and synthesized as selective COX-2 inhibitors.	methylsulfonyl	57-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
19560931-1	2009	A group of 4-carboxyl quinoline derivatives possessing a methylsulfonyl COX-2 pharmacophore at the para position of the C-2 phenyl ring were designed and synthesized as selective COX-2 inhibitors.	methylsulfonyl	57-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	179-184
19560931-2	2009	In vitro COX-1/COX-2 structure-activity relationships were determined by varying the substituents on the C-7 and C-8 quinoline ring.	quinoline	117-126	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-20
19560931-4	2009	A molecular modeling study where 9e was docked in the binding site of COX-2 showed that the p-MeSO(2) substituent on the C-2 phenyl ring is oriented in the vicinity of the COX-2 secondary pocket (Arg513, Phe518 and Val523) and the carboxyl group can interact with Arg120.	p-meso(2)	92-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-75
19560931-4	2009	A molecular modeling study where 9e was docked in the binding site of COX-2 showed that the p-MeSO(2) substituent on the C-2 phenyl ring is oriented in the vicinity of the COX-2 secondary pocket (Arg513, Phe518 and Val523) and the carboxyl group can interact with Arg120.	p-meso(2)	92-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	172-177
19560931-5	2009	The structure activity data acquired indicate that the presence of lipophilic substituents on the C-7 and C-8 quinoline ring is important for COX-2 inhibitory activity.	quinoline	110-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	142-147
19499941-4	2009	The tris(phosphinoamine) Co(I) complex (Ph(2)PNH(i)Pr)(3)CoI (8) can only be generated in the presence of an added reductant such as Zn(0), indicating that the reduction of Co(II) to Co(I) only occurs in the presence of Zr in the formation of complexes 4-6.	(2)pnh	42-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	173-179
19566094-5	2009	Spectroscopic study of photolysis solutions suggests that hydrogen production occurs through protonation of a Co(I) species to give a Co(III) hydride, which then reacts further by reduction and protolysis to give Co(II) and molecular hydrogen.	Hydrogen	58-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	213-219
19566094-5	2009	Spectroscopic study of photolysis solutions suggests that hydrogen production occurs through protonation of a Co(I) species to give a Co(III) hydride, which then reacts further by reduction and protolysis to give Co(II) and molecular hydrogen.	co(iii) hydride	134-149	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	213-219
19499941-3	2009	Interestingly, treatment of CoI(2) with the phosphinoamine Ph(2)PNH(i)Pr in the absence of a bound Zr center leads to the disubstituted Co(II) complex (Ph(2)PNH(i)Pr)(2)CoI(2) (7).	phosphinoamine	44-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	136-142
19499941-4	2009	The tris(phosphinoamine) Co(I) complex (Ph(2)PNH(i)Pr)(3)CoI (8) can only be generated in the presence of an added reductant such as Zn(0), indicating that the reduction of Co(II) to Co(I) only occurs in the presence of Zr in the formation of complexes 4-6.	Iodine	49-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	173-179
19499941-4	2009	The tris(phosphinoamine) Co(I) complex (Ph(2)PNH(i)Pr)(3)CoI (8) can only be generated in the presence of an added reductant such as Zn(0), indicating that the reduction of Co(II) to Co(I) only occurs in the presence of Zr in the formation of complexes 4-6.	tris(phosphinoamine	4-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	173-179
19499941-4	2009	The tris(phosphinoamine) Co(I) complex (Ph(2)PNH(i)Pr)(3)CoI (8) can only be generated in the presence of an added reductant such as Zn(0), indicating that the reduction of Co(II) to Co(I) only occurs in the presence of Zr in the formation of complexes 4-6.	Zinc	133-135	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	173-179
19507824-1	2009	A new polynuclear azido-bridged Co(II) compound with formula [Co(2)(N(3))(4)(HMTA)(H(2)O)](n) (1) (HMTA = hexamethylenetetramine) has been structurally and magnetically characterized.	3',5-diazido-2',3'-dideoxyuridine	18-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-37
19507824-1	2009	A new polynuclear azido-bridged Co(II) compound with formula [Co(2)(N(3))(4)(HMTA)(H(2)O)](n) (1) (HMTA = hexamethylenetetramine) has been structurally and magnetically characterized.	co(2)	62-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-37
19507824-1	2009	A new polynuclear azido-bridged Co(II) compound with formula [Co(2)(N(3))(4)(HMTA)(H(2)O)](n) (1) (HMTA = hexamethylenetetramine) has been structurally and magnetically characterized.	Methenamine	77-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-37
19507824-1	2009	A new polynuclear azido-bridged Co(II) compound with formula [Co(2)(N(3))(4)(HMTA)(H(2)O)](n) (1) (HMTA = hexamethylenetetramine) has been structurally and magnetically characterized.	Methenamine	99-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-37
19507824-1	2009	A new polynuclear azido-bridged Co(II) compound with formula [Co(2)(N(3))(4)(HMTA)(H(2)O)](n) (1) (HMTA = hexamethylenetetramine) has been structurally and magnetically characterized.	Methenamine	106-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-37
19507824-2	2009	The compound 1 crystallizes in the monoclinic system C2/m space group, and consist of a complex three-dimensional system in which end-to-end and end-on azido bridging ligands between the Co(II) atoms coexist.	3',5-diazido-2',3'-dideoxyuridine	152-157	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	187-193
19507824-3	2009	The HMTA ligand is also linking three different Co(II) atoms.	Methenamine	4-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-54
19693264-1	2009	Spectrally resolved femtosecond three-pulse photon echo signal from some metal-octaethyl porphyrins (OEPs) like Zn(II)-OEP, Ni(II)-OEP, Co(II)-OEP is reported.	metal-octaethyl porphyrins	73-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	136-142
19459660-0	2009	Antiferro- and ferromagnetic interactions in Mn(II), Co(II), and Ni(II) compounds with mixed azide-carboxylate bridges.	azide-carboxylate	93-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-58
19693264-1	2009	Spectrally resolved femtosecond three-pulse photon echo signal from some metal-octaethyl porphyrins (OEPs) like Zn(II)-OEP, Ni(II)-OEP, Co(II)-OEP is reported.	oeps	101-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	136-142
19693264-4	2009	For all these metallo-porphyrins, the electronic relaxation timescale is found to be limited by our laser pulsewidth of 50 fs whereas the timescale for intramolecular vibrational relaxation, occurring within the Q(00) band was found to be over a picosecond for Co(II)-OEP and Ni(II)-OEP and within a picosecond for Zn(II)-OEP.	Metalloporphyrins	14-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	261-267
19426794-3	2009	Nanosuspensions of celecoxib, a selective COX-2 inhibitor with low water solubility, were produced by the emulsion-diffusion method using three different stabilizers (Tween) 80, PVP K-30 and SDS) and characterized by particle size analysis, dissolution testing, scanning electron microscopy imaging, differential scanning calorimetry and X-ray powder diffraction.	Celecoxib	19-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47
19798981-4	2009	It was found that heme-iron of myoglobin directly interacted with additional Cu(II), Zn(II) and Co(II), these metal ions could drag iron ion out from heme prosthetic group of myoglobin, and subsequently myoglobin became myoglobin derivatives lacking iron ion.	Metals	110-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-102
19530988-1	2009	BACKGROUND: Most NSAIDs function by inhibiting biosynthesis of PGE(2) by inhibition of COX-1 and/or COX-2.	Prostaglandins E	63-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-105
19530988-3	2009	Attempts to identify selective inhibitors of COX-2, led to the identification of celecoxib and rofecoxib.	Celecoxib	81-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-50
19530988-3	2009	Attempts to identify selective inhibitors of COX-2, led to the identification of celecoxib and rofecoxib.	rofecoxib	95-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-50
19798981-3	2009	In the present paper, the direct interaction between heme-iron of myoglobin and additional metal ions [Cu (II), Zn (II) and Co( II)] was studied by UV-Vis spectra.	Heme	53-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	124-131
19798981-3	2009	In the present paper, the direct interaction between heme-iron of myoglobin and additional metal ions [Cu (II), Zn (II) and Co( II)] was studied by UV-Vis spectra.	Iron	58-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	124-131
19798981-3	2009	In the present paper, the direct interaction between heme-iron of myoglobin and additional metal ions [Cu (II), Zn (II) and Co( II)] was studied by UV-Vis spectra.	Metals	91-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	124-131
19798981-4	2009	It was found that heme-iron of myoglobin directly interacted with additional Cu(II), Zn(II) and Co(II), these metal ions could drag iron ion out from heme prosthetic group of myoglobin, and subsequently myoglobin became myoglobin derivatives lacking iron ion.	Heme	18-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-102
19798981-4	2009	It was found that heme-iron of myoglobin directly interacted with additional Cu(II), Zn(II) and Co(II), these metal ions could drag iron ion out from heme prosthetic group of myoglobin, and subsequently myoglobin became myoglobin derivatives lacking iron ion.	Iron	23-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-102
19798981-4	2009	It was found that heme-iron of myoglobin directly interacted with additional Cu(II), Zn(II) and Co(II), these metal ions could drag iron ion out from heme prosthetic group of myoglobin, and subsequently myoglobin became myoglobin derivatives lacking iron ion.	Iron	132-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-102
19798981-4	2009	It was found that heme-iron of myoglobin directly interacted with additional Cu(II), Zn(II) and Co(II), these metal ions could drag iron ion out from heme prosthetic group of myoglobin, and subsequently myoglobin became myoglobin derivatives lacking iron ion.	Heme	150-154	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-102
19798981-4	2009	It was found that heme-iron of myoglobin directly interacted with additional Cu(II), Zn(II) and Co(II), these metal ions could drag iron ion out from heme prosthetic group of myoglobin, and subsequently myoglobin became myoglobin derivatives lacking iron ion.	Iron	132-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-102
19798981-7	2009	When the ratio of Mb and metal ions is 1 : 10, the interaction intension between the three metal ions and Mb is Co(II), Zn(II) and Cu(II) in turn.	Metals	25-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-118
19798981-7	2009	When the ratio of Mb and metal ions is 1 : 10, the interaction intension between the three metal ions and Mb is Co(II), Zn(II) and Cu(II) in turn.	Metals	91-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-118
19798981-7	2009	When the ratio of Mb and metal ions is 1 : 10, the interaction intension between the three metal ions and Mb is Co(II), Zn(II) and Cu(II) in turn.	Zinc	120-126	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-118
19798981-7	2009	When the ratio of Mb and metal ions is 1 : 10, the interaction intension between the three metal ions and Mb is Co(II), Zn(II) and Cu(II) in turn.	cu(ii)	131-137	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-118
19842898-1	2009	PURPOSE: Our objective was to evaluate whether COX-2 inhibition with FK3311, a selective cyclooxygenase (COX)-2 inhibitor, improves transplanted liver function.	FK 3311	69-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
19487034-1	2009	Human serum albumin (HSA) is the most abundant protein of blood serum, involved in the transport of metal ions, including Co(II).	Metals	100-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-128
19842898-1	2009	PURPOSE: Our objective was to evaluate whether COX-2 inhibition with FK3311, a selective cyclooxygenase (COX)-2 inhibitor, improves transplanted liver function.	FK 3311	69-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-111
19444894-1	2009	OBJECTIVES/HYPOTHESIS: To characterize the activation of cyclooxygenase (COX)-2/prostaglandin (PG) E2 signaling during airway mucosal repair and its subsequent role during the wound healing process.	prostaglandin (pg) e2	80-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-79
19444894-13	2009	Ex vivo analysis indicates IL-1beta is responsible for the activation of the COX-2 / PGE2 pathway.	Dinoprostone	85-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-82
19428338-7	2009	IL-17A up-regulates cyclooxygenase (COX)-2 gene expression and thereby increases the level of prostaglandin (PG) E(2) in differentiated adipocyes.	Prostaglandins E	94-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-42
19534809-0	2009	Deoxycholate induces COX-2 expression via Erk1/2-, p38-MAPK and AP-1-dependent mechanisms in esophageal cancer cells.	Deoxycholic Acid	0-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-26
19534809-3	2009	The aim of this study was to investigate DCA-stimulated COX-2 signaling pathways and their possible contribution to deregulated cell survival and apoptosis in esophageal adenocarcinoma cells.	Deoxycholic Acid	41-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-61
19534809-10	2009	Induction of the anti-apoptotic protein COX-2 by DCA, via MAPK/AP-1 pathway appeared to balance the DCA mediated activation of pro-apoptotic markers such as PARP cleavage and DNA fragmentation.	Deoxycholic Acid	49-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
19534809-10	2009	Induction of the anti-apoptotic protein COX-2 by DCA, via MAPK/AP-1 pathway appeared to balance the DCA mediated activation of pro-apoptotic markers such as PARP cleavage and DNA fragmentation.	Deoxycholic Acid	100-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
19534809-11	2009	Both of these markers were increased upon COX-2 suppression by aspirin pretreatment prior to DCA exposure.	Aspirin	63-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47
19534809-11	2009	Both of these markers were increased upon COX-2 suppression by aspirin pretreatment prior to DCA exposure.	Deoxycholic Acid	93-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47
19534809-12	2009	CONCLUSION: DCA regulates both apoptosis and COX-2-regulated cell survival in esophageal cells suggesting that the balance between these two opposing signals may determine the transformation potential of DCA as a component of the refluxate.	Deoxycholic Acid	12-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-50
19534809-12	2009	CONCLUSION: DCA regulates both apoptosis and COX-2-regulated cell survival in esophageal cells suggesting that the balance between these two opposing signals may determine the transformation potential of DCA as a component of the refluxate.	Deoxycholic Acid	204-207	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-50
19585042-1	2009	A Co(II)-based catalytic system has been developed for asymmetric aziridination of alkenes with trichloroethoxysulfonyl azide (TcesN3) under mild conditions, forming the corresponding N-Tces-aziridines in high yields and excellent enantioselectivities.	tcesn3	127-133	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	2-7
19585042-1	2009	A Co(II)-based catalytic system has been developed for asymmetric aziridination of alkenes with trichloroethoxysulfonyl azide (TcesN3) under mild conditions, forming the corresponding N-Tces-aziridines in high yields and excellent enantioselectivities.	n-tces-aziridines	184-201	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	2-7
19397918-8	2009	The potential involvement of microglial PGE(2) in enhanced astrocyte proliferation was suggested by the findings that PGE(2) production and COX-2 expression in microglia were increased by LPS treatment.	Dinoprostone	40-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-145
19513479-0	2009	Luminescent sensing and formation of mixed f-d metal ion complexes between a Eu(iii)-cyclen-phen conjugate and Cu(ii), Fe(ii), and Co(ii) in buffered aqueous solution.	Metals	47-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-82
19513479-0	2009	Luminescent sensing and formation of mixed f-d metal ion complexes between a Eu(iii)-cyclen-phen conjugate and Cu(ii), Fe(ii), and Co(ii) in buffered aqueous solution.	Metals	47-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-116
19513479-0	2009	Luminescent sensing and formation of mixed f-d metal ion complexes between a Eu(iii)-cyclen-phen conjugate and Cu(ii), Fe(ii), and Co(ii) in buffered aqueous solution.	Metals	47-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-137
19513479-0	2009	Luminescent sensing and formation of mixed f-d metal ion complexes between a Eu(iii)-cyclen-phen conjugate and Cu(ii), Fe(ii), and Co(ii) in buffered aqueous solution.	1,10-phenanthroline	92-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-116
19513479-0	2009	Luminescent sensing and formation of mixed f-d metal ion complexes between a Eu(iii)-cyclen-phen conjugate and Cu(ii), Fe(ii), and Co(ii) in buffered aqueous solution.	1,10-phenanthroline	92-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-137
19513479-3	2009	This allowed for the use of as a luminescent sensor for transition metal ions, where the titration with ions such as Cu(ii), Co(ii) and Fe(ii) gave rise to the formation of mixed f-d nuclear complexes, with concomitant changes in the photophysical properties of .	Metals	67-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-122
19513479-3	2009	This allowed for the use of as a luminescent sensor for transition metal ions, where the titration with ions such as Cu(ii), Co(ii) and Fe(ii) gave rise to the formation of mixed f-d nuclear complexes, with concomitant changes in the photophysical properties of .	Metals	67-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-131
19513479-3	2009	This allowed for the use of as a luminescent sensor for transition metal ions, where the titration with ions such as Cu(ii), Co(ii) and Fe(ii) gave rise to the formation of mixed f-d nuclear complexes, with concomitant changes in the photophysical properties of .	Metals	67-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	128-130
19513479-6	2009	From these changes, we were able to demonstrate the binding stoichiometry and the binding constant for the formation of novel supramolecular complexes between and Cu(ii), Co(ii) and Fe(ii), which showed that either two or three equivalents of complexed to each of these transition metal ions, giving rise to the formation either linear f-d-f or branched f(3)-d based mixed nuclear complexes in solution.	Metals	281-286	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	166-168
19513479-6	2009	From these changes, we were able to demonstrate the binding stoichiometry and the binding constant for the formation of novel supramolecular complexes between and Cu(ii), Co(ii) and Fe(ii), which showed that either two or three equivalents of complexed to each of these transition metal ions, giving rise to the formation either linear f-d-f or branched f(3)-d based mixed nuclear complexes in solution.	Metals	281-286	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	171-177
19513479-6	2009	From these changes, we were able to demonstrate the binding stoichiometry and the binding constant for the formation of novel supramolecular complexes between and Cu(ii), Co(ii) and Fe(ii), which showed that either two or three equivalents of complexed to each of these transition metal ions, giving rise to the formation either linear f-d-f or branched f(3)-d based mixed nuclear complexes in solution.	Metals	281-286	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	174-176
19336478-7	2009	The subsequent maturation of CO II is contingent upon the formation of a complex that includes both SCO proteins, each with a functional CxxxC copper-coordinating motif.	Copper	143-149	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34
21582700-1	2009	In the title complex, [Co(C(22)H(24)N(2)O(4))] H(2)O, the Co(II) atom is in an almost square-planar coordination environment involv-ing two O and two N atoms from the Schiff base ligand.	Cobalt	23-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-64
19393246-7	2009	This observation may indicate that the absence of Cox17 interferes with copper delivery to Cox2, but not to Cox1.	Copper	72-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-95
21582700-1	2009	In the title complex, [Co(C(22)H(24)N(2)O(4))] H(2)O, the Co(II) atom is in an almost square-planar coordination environment involv-ing two O and two N atoms from the Schiff base ligand.	Carbon	23-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-64
21582700-1	2009	In the title complex, [Co(C(22)H(24)N(2)O(4))] H(2)O, the Co(II) atom is in an almost square-planar coordination environment involv-ing two O and two N atoms from the Schiff base ligand.	Nitrogen	36-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-64
21582700-1	2009	In the title complex, [Co(C(22)H(24)N(2)O(4))] H(2)O, the Co(II) atom is in an almost square-planar coordination environment involv-ing two O and two N atoms from the Schiff base ligand.	Schiff Bases	167-178	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-64
19452070-3	2009	In contrast, a mixture of octahedral [M = Co(ii) or Ni(ii)] and tetrahedral [Ag(i)] metal ions reacts with L to afford the simpler trinuclear heterometallic complexes [Co(2)AgL(2)](BF(4))(5) in which the requirements of the metal ions (for 3 + 3 + 2 bidentate arms) are matched by two four-armed ligands.	l	107-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-48
19368394-2	2009	Here, a Co(II)-mediated dimeric mithramycin (Mith) complex, (Mith)(2)-Co(II), was shown to be resistant to polyamine competition toward the divalent metal ion when compared to the Fe(II)-mediated drug complexes.	Plicamycin	32-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	8-13
19368394-2	2009	Here, a Co(II)-mediated dimeric mithramycin (Mith) complex, (Mith)(2)-Co(II), was shown to be resistant to polyamine competition toward the divalent metal ion when compared to the Fe(II)-mediated drug complexes.	Plicamycin	32-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-75
19368394-2	2009	Here, a Co(II)-mediated dimeric mithramycin (Mith) complex, (Mith)(2)-Co(II), was shown to be resistant to polyamine competition toward the divalent metal ion when compared to the Fe(II)-mediated drug complexes.	Plicamycin	45-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	8-13
19470469-1	2009	Pharmacologic inhibitors of the prostaglandin-synthesizing COX-2 oncogene prevent the development of premalignant human colon adenomas.	Prostaglandins	32-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-64
19452070-3	2009	In contrast, a mixture of octahedral [M = Co(ii) or Ni(ii)] and tetrahedral [Ag(i)] metal ions reacts with L to afford the simpler trinuclear heterometallic complexes [Co(2)AgL(2)](BF(4))(5) in which the requirements of the metal ions (for 3 + 3 + 2 bidentate arms) are matched by two four-armed ligands.	l	107-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-47
19368394-2	2009	Here, a Co(II)-mediated dimeric mithramycin (Mith) complex, (Mith)(2)-Co(II), was shown to be resistant to polyamine competition toward the divalent metal ion when compared to the Fe(II)-mediated drug complexes.	Plicamycin	45-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-75
19436090-1	2009	Cobalt nanostructures have been prepared by a chemical route based on the Co(II) reduction in the confined space of cobalt bis(2-ethylhexyl)sulfosuccinate (Co(DEHSS)(2)) reverse micelles dispersed in n-heptane.	Cobalt	0-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-80
19368394-2	2009	Here, a Co(II)-mediated dimeric mithramycin (Mith) complex, (Mith)(2)-Co(II), was shown to be resistant to polyamine competition toward the divalent metal ion when compared to the Fe(II)-mediated drug complexes.	(mith)(2)-	60-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	8-13
19368394-2	2009	Here, a Co(II)-mediated dimeric mithramycin (Mith) complex, (Mith)(2)-Co(II), was shown to be resistant to polyamine competition toward the divalent metal ion when compared to the Fe(II)-mediated drug complexes.	Polyamines	107-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	8-13
19368394-2	2009	Here, a Co(II)-mediated dimeric mithramycin (Mith) complex, (Mith)(2)-Co(II), was shown to be resistant to polyamine competition toward the divalent metal ion when compared to the Fe(II)-mediated drug complexes.	Polyamines	107-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-75
19368394-2	2009	Here, a Co(II)-mediated dimeric mithramycin (Mith) complex, (Mith)(2)-Co(II), was shown to be resistant to polyamine competition toward the divalent metal ion when compared to the Fe(II)-mediated drug complexes.	Metals	149-154	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	8-13
19368394-2	2009	Here, a Co(II)-mediated dimeric mithramycin (Mith) complex, (Mith)(2)-Co(II), was shown to be resistant to polyamine competition toward the divalent metal ion when compared to the Fe(II)-mediated drug complexes.	Metals	149-154	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-75
19368394-2	2009	Here, a Co(II)-mediated dimeric mithramycin (Mith) complex, (Mith)(2)-Co(II), was shown to be resistant to polyamine competition toward the divalent metal ion when compared to the Fe(II)-mediated drug complexes.	ammonium ferrous sulfate	180-186	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	8-13
19368394-2	2009	Here, a Co(II)-mediated dimeric mithramycin (Mith) complex, (Mith)(2)-Co(II), was shown to be resistant to polyamine competition toward the divalent metal ion when compared to the Fe(II)-mediated drug complexes.	ammonium ferrous sulfate	180-186	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-75
19368394-3	2009	Surface plasmon resonance experiments demonstrated that polyamines interfered with the binding capacity and association rates of (Mith)(2)-Co(II) binding to DNA duplexes, while the dissociation rates were not affected.	Polyamines	56-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-144
19368394-4	2009	Although (Mith)(2)-Co(II) exhibited the highest oxidative activity under physiological conditions (pH 7.3 and 37 degrees C), polyamines (spermine in particular) inhibited the DNA cleavage activity of the (Mith)(2)-Co(II) in a concentration-dependent manner.	Polyamines	125-135	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	214-219
19368394-4	2009	Although (Mith)(2)-Co(II) exhibited the highest oxidative activity under physiological conditions (pH 7.3 and 37 degrees C), polyamines (spermine in particular) inhibited the DNA cleavage activity of the (Mith)(2)-Co(II) in a concentration-dependent manner.	Spermine	137-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	214-219
19368394-5	2009	Depletion of intracellular polyamines by methylglyoxal bis(guanylhydrazone) (MGBG) enhanced the sensitivity of A549 lung cancer cells to (Mith)(2)-Co(II), most likely due to the decreased intracellular effect of polyamines on the action of (Mith)(2)-Co(II).	Polyamines	27-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-152
19368394-5	2009	Depletion of intracellular polyamines by methylglyoxal bis(guanylhydrazone) (MGBG) enhanced the sensitivity of A549 lung cancer cells to (Mith)(2)-Co(II), most likely due to the decreased intracellular effect of polyamines on the action of (Mith)(2)-Co(II).	Polyamines	27-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	250-255
19368394-5	2009	Depletion of intracellular polyamines by methylglyoxal bis(guanylhydrazone) (MGBG) enhanced the sensitivity of A549 lung cancer cells to (Mith)(2)-Co(II), most likely due to the decreased intracellular effect of polyamines on the action of (Mith)(2)-Co(II).	Mitoguazone	41-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-152
19368394-5	2009	Depletion of intracellular polyamines by methylglyoxal bis(guanylhydrazone) (MGBG) enhanced the sensitivity of A549 lung cancer cells to (Mith)(2)-Co(II), most likely due to the decreased intracellular effect of polyamines on the action of (Mith)(2)-Co(II).	Mitoguazone	77-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-152
19368394-5	2009	Depletion of intracellular polyamines by methylglyoxal bis(guanylhydrazone) (MGBG) enhanced the sensitivity of A549 lung cancer cells to (Mith)(2)-Co(II), most likely due to the decreased intracellular effect of polyamines on the action of (Mith)(2)-Co(II).	Mitoguazone	77-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	250-255
19368394-5	2009	Depletion of intracellular polyamines by methylglyoxal bis(guanylhydrazone) (MGBG) enhanced the sensitivity of A549 lung cancer cells to (Mith)(2)-Co(II), most likely due to the decreased intracellular effect of polyamines on the action of (Mith)(2)-Co(II).	Polyamines	212-222	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-152
19402097-4	2009	Mono-Co(II) complex 1-Co was selectively produced from metalation with the Co(II) ion, from which hybrid complex 1-CoCu was synthesized.	1-Co	20-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	5-11
19402097-4	2009	Mono-Co(II) complex 1-Co was selectively produced from metalation with the Co(II) ion, from which hybrid complex 1-CoCu was synthesized.	1-Co	20-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-81
19413344-0	2009	Asymmetric Co(II)-catalyzed cyclopropanation with succinimidyl diazoacetate: general synthesis of chiral cyclopropyl carboxamides.	succinimidyl diazoacetate	50-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-17
19413344-0	2009	Asymmetric Co(II)-catalyzed cyclopropanation with succinimidyl diazoacetate: general synthesis of chiral cyclopropyl carboxamides.	cyclopropyl carboxamides	105-129	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-17
19413344-2	2009	The Co(II)-catalyzed reaction is suitable for various olefins, providing the desired cyclopropane succinimidyl esters in high yields and excellent diastereo- and enantioselectivity.	Alkenes	54-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
19413344-2	2009	The Co(II)-catalyzed reaction is suitable for various olefins, providing the desired cyclopropane succinimidyl esters in high yields and excellent diastereo- and enantioselectivity.	cyclopropane succinimidyl esters	85-117	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
19436090-1	2009	Cobalt nanostructures have been prepared by a chemical route based on the Co(II) reduction in the confined space of cobalt bis(2-ethylhexyl)sulfosuccinate (Co(DEHSS)(2)) reverse micelles dispersed in n-heptane.	cobalt bis(2-ethylhexyl)sulfosuccinate	116-154	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-80
19436090-1	2009	Cobalt nanostructures have been prepared by a chemical route based on the Co(II) reduction in the confined space of cobalt bis(2-ethylhexyl)sulfosuccinate (Co(DEHSS)(2)) reverse micelles dispersed in n-heptane.	co(dehss)	156-165	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-80
19082758-0	2009	p53 and ATF-2 partly mediate the overexpression of COX-2 in H(2)O (2)-induced premature senescence of human fibroblasts.	Hydrogen Peroxide	60-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-56
19479756-0	2009	Pyrazolo[3,4-d]pyrimidine derivatives as COX-2 selective inhibitors: synthesis and molecular modelling studies.	pyrazolo(3,4-d)pyrimidine	0-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-46
19382759-4	2009	The influence of the pH is also crucial, and this has been linked to the pH dependence of the precursor Co(III/)(II) redox potentials in terms of enabling a redox-assisted association (at low pH) between the ferricyanide analogue and the labile Co(II) partner.	hexacyanoferrate III	208-220	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	245-251
19382759-10	2009	Formation of the tetranuclear (Co(III)L)(3)/Fe(II) complexes has only been detected on decomposition of the parent trinuclear (Co(III)L)(2)/Fe(II) complexes following reduction to their Co(II) form.	ammonium ferrous sulfate	140-146	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	186-192
19205707-1	2009	PURPOSE: Cyclooxygenase (COX) enzymes, COX1 and COX2, are key in converting arachidonic acid (AA) into prostaglandins that have been associated with colorectal carcinogenesis.	Arachidonic Acid	76-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-52
19205707-1	2009	PURPOSE: Cyclooxygenase (COX) enzymes, COX1 and COX2, are key in converting arachidonic acid (AA) into prostaglandins that have been associated with colorectal carcinogenesis.	Prostaglandins	103-117	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-52
19419861-3	2009	The ester prodrugs (12a-c, 14a-c), which did not inhibit the COX-1 isozyme, exhibited modest inhibitory activity against the COX-2 isozyme.	Esters	4-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-130
19470791-3	2009	To selectively design out the COX inhibitory activity of sulindac sulfide (SS), in silico modeling studies were done that revealed the crucial role of the carboxylate moiety for COX-1 and COX-2 binding.	sulindac sulfide	57-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	188-193
19470791-3	2009	To selectively design out the COX inhibitory activity of sulindac sulfide (SS), in silico modeling studies were done that revealed the crucial role of the carboxylate moiety for COX-1 and COX-2 binding.	sulindac sulfide	75-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	188-193
19470791-3	2009	To selectively design out the COX inhibitory activity of sulindac sulfide (SS), in silico modeling studies were done that revealed the crucial role of the carboxylate moiety for COX-1 and COX-2 binding.	carboxylate	155-166	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	188-193
19470791-5	2009	A SS amide (SSA) with a N,N-dimethylethyl amine substitution was found to lack COX-1 and COX-2 inhibitory activity, yet potently inhibit the growth of human colon tumor cell lines, HT-29, SW480, and HCT116 with IC(50) values of 2 to 5 micromol/L compared with 73 to 85 micromol/L for SS.	Amides	5-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-94
19470791-5	2009	A SS amide (SSA) with a N,N-dimethylethyl amine substitution was found to lack COX-1 and COX-2 inhibitory activity, yet potently inhibit the growth of human colon tumor cell lines, HT-29, SW480, and HCT116 with IC(50) values of 2 to 5 micromol/L compared with 73 to 85 micromol/L for SS.	sulindac sulfide amide	12-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-94
19470791-5	2009	A SS amide (SSA) with a N,N-dimethylethyl amine substitution was found to lack COX-1 and COX-2 inhibitory activity, yet potently inhibit the growth of human colon tumor cell lines, HT-29, SW480, and HCT116 with IC(50) values of 2 to 5 micromol/L compared with 73 to 85 micromol/L for SS.	sulindac sulfide	2-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-94
19601807-2	2009	Rvs are biosynthesized from omega-3 fatty acids eicosapentanoic acid (EPA) and docosahexaenoic acid (DHA) via cyclooxygenase-2/lipoxygenase (COX-2/LOX) pathways; Rvs are shown to dramatically reduce dermal inflammation, peritonitis, dendritic cell migration, and interleukin production.	Fatty Acids, Omega-3	28-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	141-146
19601807-2	2009	Rvs are biosynthesized from omega-3 fatty acids eicosapentanoic acid (EPA) and docosahexaenoic acid (DHA) via cyclooxygenase-2/lipoxygenase (COX-2/LOX) pathways; Rvs are shown to dramatically reduce dermal inflammation, peritonitis, dendritic cell migration, and interleukin production.	Eicosapentaenoic Acid	48-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	141-146
19601807-2	2009	Rvs are biosynthesized from omega-3 fatty acids eicosapentanoic acid (EPA) and docosahexaenoic acid (DHA) via cyclooxygenase-2/lipoxygenase (COX-2/LOX) pathways; Rvs are shown to dramatically reduce dermal inflammation, peritonitis, dendritic cell migration, and interleukin production.	Eicosapentaenoic Acid	70-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	141-146
19601807-2	2009	Rvs are biosynthesized from omega-3 fatty acids eicosapentanoic acid (EPA) and docosahexaenoic acid (DHA) via cyclooxygenase-2/lipoxygenase (COX-2/LOX) pathways; Rvs are shown to dramatically reduce dermal inflammation, peritonitis, dendritic cell migration, and interleukin production.	Docosahexaenoic Acids	79-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	141-146
19601807-2	2009	Rvs are biosynthesized from omega-3 fatty acids eicosapentanoic acid (EPA) and docosahexaenoic acid (DHA) via cyclooxygenase-2/lipoxygenase (COX-2/LOX) pathways; Rvs are shown to dramatically reduce dermal inflammation, peritonitis, dendritic cell migration, and interleukin production.	Docosahexaenoic Acids	101-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	141-146
19601807-4	2009	LXs are biosynthesized from COX-2/LOX pathways.	Lipoxins	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
19601807-5	2009	Metabolites of 15-LOX-1 and 2 are anti-tumorigenic; similarly, 15-epi-LXA(4) synthesized during COX-2 acetylation by low doses of aspirin too possesses anti-tumorigenic effects.	15-epi-lxa	63-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-101
19601807-5	2009	Metabolites of 15-LOX-1 and 2 are anti-tumorigenic; similarly, 15-epi-LXA(4) synthesized during COX-2 acetylation by low doses of aspirin too possesses anti-tumorigenic effects.	Aspirin	130-137	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-101
19601807-6	2009	Acetylating nonsteroidal anti-inflammatory drugs (NSAIDs), like aspirin, switches COX-2 from forming PGE(2) (promoting tumorigenesis) to 15-epi-LXA(4) (antitumorigenesis).	Aspirin	64-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
19601807-6	2009	Acetylating nonsteroidal anti-inflammatory drugs (NSAIDs), like aspirin, switches COX-2 from forming PGE(2) (promoting tumorigenesis) to 15-epi-LXA(4) (antitumorigenesis).	Prostaglandins E	101-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
19601807-6	2009	Acetylating nonsteroidal anti-inflammatory drugs (NSAIDs), like aspirin, switches COX-2 from forming PGE(2) (promoting tumorigenesis) to 15-epi-LXA(4) (antitumorigenesis).	15-epi-lxa	137-147	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
19409858-0	2009	A randomized, double-blind, placebo-controlled trial of a selective COX-2 inhibitor, GW406381, in patients with postherpetic neuralgia.	GW406381X	85-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-73
19409858-1	2009	UNLABELLED: In this randomized, double-blind, placebo-controlled study, we evaluated the efficacy and safety of GW406381, an investigational selective cyclooxygenase (COX)-2 inhibitor with both peripheral and central actions, in 209 patients with postherpetic neuralgia (PHN).	GW406381X	112-120	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-173
19382759-10	2009	Formation of the tetranuclear (Co(III)L)(3)/Fe(II) complexes has only been detected on decomposition of the parent trinuclear (Co(III)L)(2)/Fe(II) complexes following reduction to their Co(II) form.	ammonium ferrous sulfate	44-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	186-192
19382759-10	2009	Formation of the tetranuclear (Co(III)L)(3)/Fe(II) complexes has only been detected on decomposition of the parent trinuclear (Co(III)L)(2)/Fe(II) complexes following reduction to their Co(II) form.	trinuclear	115-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	186-192
19437483-3	2009	In this study, we compared the effects of 18-carbon fatty acids with different degrees of unsaturation on the expression of the proinflammatory genes cyclooxygenase (COX)-2 and inducible nitric oxide synthase (iNOS) in human retinal pigment epithelium (RPE).	18-carbon fatty acids	42-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	150-172
19318593-1	2009	Cyclooxygenase (COX)-2 is a central enzyme of arachidonic acid metabolism, and its modulation by statins may explain some of the myocardial protective effects of these drugs.	Arachidonic Acid	46-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-22
19318593-2	2009	Dendritic cells (DCs) play a central role in microbial defense and in atherogenesis, and COX-2 expression in DCs is important for their migration to lymph nodes and antibody response, thus explaining why prostaglandin E(2) is a main component of the cocktails used to prepare DCs for clinical applications.	Dinoprostone	204-222	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-94
19318593-3	2009	On this basis, we addressed the effect of atorvastatin (ATV) on the release of arachidonic acid and on the expression of COX-2 in human monocyte-derived DCs.	Atorvastatin	56-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-126
19318593-4	2009	Although ATV on its own lacked any effect on COX-2 protein induction expression, it enhanced the release of arachidonic acid, the expression of COX-2 protein, and the production of prostaglandin E(2) induced by the fungal wall extract zymosan, and to a lower extent the effect of peptidoglycan.	Atorvastatin	9-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	144-149
19318593-5	2009	The effect on COX-2 protein was observed mainly 24 h after stimulation by zymosan and was not reverted by mevalonate, thus pointing to an effect unrelated to cholesterol metabolism.	Zymosan	74-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
19318593-6	2009	It is noteworthy that COX-2 protein showed a great stability, with a t((1/2)) of approximately 12 h, which was enhanced in the presence of ATV.	Atorvastatin	139-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-27
19318593-7	2009	In view of the important role played by COX-2 on DC function, these data indicate that ATV, by enhancing COX-2 stability, may increase DC function after infectious bouts and also counteract some of the risks associated with sustained inhibition of COX-2.	Atorvastatin	87-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
19318593-7	2009	In view of the important role played by COX-2 on DC function, these data indicate that ATV, by enhancing COX-2 stability, may increase DC function after infectious bouts and also counteract some of the risks associated with sustained inhibition of COX-2.	Atorvastatin	87-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-110
19318593-7	2009	In view of the important role played by COX-2 on DC function, these data indicate that ATV, by enhancing COX-2 stability, may increase DC function after infectious bouts and also counteract some of the risks associated with sustained inhibition of COX-2.	Atorvastatin	87-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-110
19437483-5	2009	Treatment with oleic acid, linoleic acid (LA), or linolenic acid increased the expression of iNOS and COX-2 genes and the production of prostaglandin E(2 )and nitric oxide (NO) in RPE, whereas the saturated fatty acid stearic acid had little effect on these genes.	Oleic Acid	15-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-107
19440636-5	2009	In particular, the reactivity of the isolated Co(II) porphyrin species towards nitric oxide (NO) is investigated, with possible implications in the understanding of the crucial role played by NO in biological systems.	Nitric Oxide	79-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-52
19469000-6	2009	RESULTS: Nicotine (100 microg/mL, 200 microg/mL) enhanced TE-13 cells migration and invasion, and increased the protein expression of COX-2 and the activity of MMP-2.	Nicotine	9-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-139
19470170-13	2009	The cox-2 inhibitor Etoricoxib was found to negate or increase the action of two other drugs (Leflunomide and Dexamethasone).	Etoricoxib	20-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
19470170-13	2009	The cox-2 inhibitor Etoricoxib was found to negate or increase the action of two other drugs (Leflunomide and Dexamethasone).	Leflunomide	94-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
19470170-13	2009	The cox-2 inhibitor Etoricoxib was found to negate or increase the action of two other drugs (Leflunomide and Dexamethasone).	Dexamethasone	110-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
19385618-1	2009	Octahedral transition metal centers such as Fe(II), Co(II), and Co(III) have been used as templates in the construction of [3]pseudorotaxanes and [3]rotaxanes from various acyclic and macrocyclic fragments.	[3]pseudorotaxanes	123-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-58
19385618-1	2009	Octahedral transition metal centers such as Fe(II), Co(II), and Co(III) have been used as templates in the construction of [3]pseudorotaxanes and [3]rotaxanes from various acyclic and macrocyclic fragments.	Rotaxanes	132-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-58
19385618-8	2009	The Fe(II) and Co(III) complexes were characterized by (1)H NMR and ES-MS. By taking advantage of the markedly different kinetic properties of the two oxidation states, Co(II) and Co(III), it was possible to proceed to fast coordination or decoordination reactions (for the divalent state) or, when needed, to "freeze" the complexes due to the kinetic inertness of the trivalent state and to study them by (1)H NMR.	ammonium ferrous sulfate	4-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	169-175
19385618-10	2009	This demetalation reaction was fast for the Co(II)-complexed [3]rotaxane, whereas decomplexation of the Fe(II) equivalent required harsh conditions which were not compatible with the stability of the metal-free rotaxane.	Metals	7-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-49
19398345-8	2009	In addition, docking of the mutual ester prodrugs (6-8) into COX-2 active site was conducted in order to predict the affinity and orientation of these prodrugs at the enzyme active site.	Esters	35-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-66
18579232-1	2009	We demonstrate that serum IgG in chagasic patients interacting with the second extracellular loop of human cardiac M(2) muscarinic acetylcholine receptors (M(2) mAChR) trigger the production of PGE(2) and NO, that in turn induces COX-2/iNOS mRNA expression.	Prostaglandins E	194-197	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	230-235
18579232-6	2009	Inhibition of these enzymes shows that chagasic autoantibodies up-regulation of COX-2/iNOS mRNA level is under the control of endogenous iNO/cGMP signaling system.	Cyclic GMP	141-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-85
19330880-0	2009	Differentiation of human osteosarcoma cells by isolated phlorotannins is subtly linked to COX-2, iNOS, MMPs, and MAPK signaling: implication for chronic articular disease.	phlorotannins	56-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-95
19330880-5	2009	Furthermore, these phlorotannin derivatives (1, 2) inhibited mRNA gene and protein levels of matrix metalloproteinase (MMP-1, MMP-3, and MMP-13), iNOS and COX-2 in casein zymography, Western blot and reverse transcriptase-polymerase chain reaction (RT-PCR) assays.	phlorotannin	19-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	155-160
19358538-4	2009	Valence ambiguous 1(3+) forms via redox-induced electron transfer, whereby the one-electron oxidation of the [Co(II)(DBQ(2-))Co(II)](2+) core forms [Co(III)(DBQ(*3-))Co(III)](3+), and it also exhibits spin crossover behavior to the core [Co(III)(DBQ(2-))Co(II)](3+) above room temperature.	dbq(2-)	117-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-116
19358538-4	2009	Valence ambiguous 1(3+) forms via redox-induced electron transfer, whereby the one-electron oxidation of the [Co(II)(DBQ(2-))Co(II)](2+) core forms [Co(III)(DBQ(*3-))Co(III)](3+), and it also exhibits spin crossover behavior to the core [Co(III)(DBQ(2-))Co(II)](3+) above room temperature.	dbq(2-)	117-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-131
19358538-4	2009	Valence ambiguous 1(3+) forms via redox-induced electron transfer, whereby the one-electron oxidation of the [Co(II)(DBQ(2-))Co(II)](2+) core forms [Co(III)(DBQ(*3-))Co(III)](3+), and it also exhibits spin crossover behavior to the core [Co(III)(DBQ(2-))Co(II)](3+) above room temperature.	dbq(2-)	117-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-131
19358538-4	2009	Valence ambiguous 1(3+) forms via redox-induced electron transfer, whereby the one-electron oxidation of the [Co(II)(DBQ(2-))Co(II)](2+) core forms [Co(III)(DBQ(*3-))Co(III)](3+), and it also exhibits spin crossover behavior to the core [Co(III)(DBQ(2-))Co(II)](3+) above room temperature.	co(iii)	149-156	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-116
19358538-4	2009	Valence ambiguous 1(3+) forms via redox-induced electron transfer, whereby the one-electron oxidation of the [Co(II)(DBQ(2-))Co(II)](2+) core forms [Co(III)(DBQ(*3-))Co(III)](3+), and it also exhibits spin crossover behavior to the core [Co(III)(DBQ(2-))Co(II)](3+) above room temperature.	co(iii)	149-156	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-131
19358538-4	2009	Valence ambiguous 1(3+) forms via redox-induced electron transfer, whereby the one-electron oxidation of the [Co(II)(DBQ(2-))Co(II)](2+) core forms [Co(III)(DBQ(*3-))Co(III)](3+), and it also exhibits spin crossover behavior to the core [Co(III)(DBQ(2-))Co(II)](3+) above room temperature.	co(iii)	149-156	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-131
19358538-4	2009	Valence ambiguous 1(3+) forms via redox-induced electron transfer, whereby the one-electron oxidation of the [Co(II)(DBQ(2-))Co(II)](2+) core forms [Co(III)(DBQ(*3-))Co(III)](3+), and it also exhibits spin crossover behavior to the core [Co(III)(DBQ(2-))Co(II)](3+) above room temperature.	dbq(*3-))co(iii)	157-173	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-116
19358538-4	2009	Valence ambiguous 1(3+) forms via redox-induced electron transfer, whereby the one-electron oxidation of the [Co(II)(DBQ(2-))Co(II)](2+) core forms [Co(III)(DBQ(*3-))Co(III)](3+), and it also exhibits spin crossover behavior to the core [Co(III)(DBQ(2-))Co(II)](3+) above room temperature.	dbq(*3-))co(iii)	157-173	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-131
19358538-4	2009	Valence ambiguous 1(3+) forms via redox-induced electron transfer, whereby the one-electron oxidation of the [Co(II)(DBQ(2-))Co(II)](2+) core forms [Co(III)(DBQ(*3-))Co(III)](3+), and it also exhibits spin crossover behavior to the core [Co(III)(DBQ(2-))Co(II)](3+) above room temperature.	dbq(*3-))co(iii)	157-173	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-131
19358538-4	2009	Valence ambiguous 1(3+) forms via redox-induced electron transfer, whereby the one-electron oxidation of the [Co(II)(DBQ(2-))Co(II)](2+) core forms [Co(III)(DBQ(*3-))Co(III)](3+), and it also exhibits spin crossover behavior to the core [Co(III)(DBQ(2-))Co(II)](3+) above room temperature.	co(iii)	166-173	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-116
19358538-4	2009	Valence ambiguous 1(3+) forms via redox-induced electron transfer, whereby the one-electron oxidation of the [Co(II)(DBQ(2-))Co(II)](2+) core forms [Co(III)(DBQ(*3-))Co(III)](3+), and it also exhibits spin crossover behavior to the core [Co(III)(DBQ(2-))Co(II)](3+) above room temperature.	co(iii)	166-173	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-131
19358538-4	2009	Valence ambiguous 1(3+) forms via redox-induced electron transfer, whereby the one-electron oxidation of the [Co(II)(DBQ(2-))Co(II)](2+) core forms [Co(III)(DBQ(*3-))Co(III)](3+), and it also exhibits spin crossover behavior to the core [Co(III)(DBQ(2-))Co(II)](3+) above room temperature.	co(iii)	166-173	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-131
19358538-4	2009	Valence ambiguous 1(3+) forms via redox-induced electron transfer, whereby the one-electron oxidation of the [Co(II)(DBQ(2-))Co(II)](2+) core forms [Co(III)(DBQ(*3-))Co(III)](3+), and it also exhibits spin crossover behavior to the core [Co(III)(DBQ(2-))Co(II)](3+) above room temperature.	dbq(2-)	246-253	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-116
19358538-4	2009	Valence ambiguous 1(3+) forms via redox-induced electron transfer, whereby the one-electron oxidation of the [Co(II)(DBQ(2-))Co(II)](2+) core forms [Co(III)(DBQ(*3-))Co(III)](3+), and it also exhibits spin crossover behavior to the core [Co(III)(DBQ(2-))Co(II)](3+) above room temperature.	dbq(2-)	246-253	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-131
19358538-4	2009	Valence ambiguous 1(3+) forms via redox-induced electron transfer, whereby the one-electron oxidation of the [Co(II)(DBQ(2-))Co(II)](2+) core forms [Co(III)(DBQ(*3-))Co(III)](3+), and it also exhibits spin crossover behavior to the core [Co(III)(DBQ(2-))Co(II)](3+) above room temperature.	dbq(2-)	246-253	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-131
19189297-5	2009	The antitumor activity of CDDO-Me was associated with the inhibition of p-Akt, mammalian target of rapamycin (mTOR), and nuclear factor kappa B (NF-kappaB) signaling proteins and their downstream targets such as p-Bad and p-Foxo3a (Akt); p-S6K1, p-eIF-4E and p-4E-BP1 (mTOR); and COX-2, VEGF and cyclin D1(NF-kappaB).	bardoxolone methyl	26-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	280-285
19399766-1	2009	Electrospray ionization mass spectrometry (ESI-MS) is used to probe the metal-binding selectivity of a macrocyclic thiacrown ether (C(44)H(32)S(20)) towards Co(II), Ni(II), Cu(II), and Zn(II).	Metals	72-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	157-163
19399766-1	2009	Electrospray ionization mass spectrometry (ESI-MS) is used to probe the metal-binding selectivity of a macrocyclic thiacrown ether (C(44)H(32)S(20)) towards Co(II), Ni(II), Cu(II), and Zn(II).	thiacrown ether	115-130	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	157-163
19399766-1	2009	Electrospray ionization mass spectrometry (ESI-MS) is used to probe the metal-binding selectivity of a macrocyclic thiacrown ether (C(44)H(32)S(20)) towards Co(II), Ni(II), Cu(II), and Zn(II).	Nickel(2+)	165-171	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	157-163
19399766-1	2009	Electrospray ionization mass spectrometry (ESI-MS) is used to probe the metal-binding selectivity of a macrocyclic thiacrown ether (C(44)H(32)S(20)) towards Co(II), Ni(II), Cu(II), and Zn(II).	cu(ii)	173-179	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	157-163
19399766-1	2009	Electrospray ionization mass spectrometry (ESI-MS) is used to probe the metal-binding selectivity of a macrocyclic thiacrown ether (C(44)H(32)S(20)) towards Co(II), Ni(II), Cu(II), and Zn(II).	Zinc	185-191	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	157-163
19399766-3	2009	The large selectivity is ascribed to the redox-active nature of copper which enables a reduction from Cu(II) to Cu(I), occurring upon ESI-MS, whereas Co(II), Ni(II) and Zn(II) cannot undergo similar redox reactions.	Copper	64-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	150-156
19493461-15	2009	Aspirin decreased COX-2 expression in a dose-dependent manner at mRNA and protein levels.	Aspirin	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-23
19359174-1	2009	Six new mixed-ligand complexes of Co(II) with ciprofloxacin (Cip) and neutral bidentate ligands have been synthesized and characterized.	Ciprofloxacin	46-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-39
19359174-1	2009	Six new mixed-ligand complexes of Co(II) with ciprofloxacin (Cip) and neutral bidentate ligands have been synthesized and characterized.	Ciprofloxacin	61-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-39
19363520-9	2009	Furthermore, forced expression of DeltaNp73(AS) results in diminished apoptosis in response to the selective COX-2 inhibitor celecoxib.	Celecoxib	125-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-114
19358538-10	2009	The first three correspond to [Co(II)DBQ(2-)Co(II)](2+) reduction to [Co(II)DBQ(*3-)Co(II)](+), and oxidation to [Co(III)DBQ(*3-)Co(III)](3+) and [Co(III)DBQ(2-)Co(III)](4+), respectively.	co(iii)	129-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-50
19376970-3	2009	Tamoxifen induced selective deletion of COX-2 in cardiomyocytes depressed cardiac output, and resulted in weight loss, diminished exercise tolerance, and enhanced susceptibility to induced arrhythmogenesis.	Tamoxifen	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
19428940-6	2009	It was shown that Delta(9)-THC-induced MCF-7 cell growth was inhibited by COX-2 inhibitors and was stimulated by arachidonic acid (a COX substrate).	Dronabinol	18-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
19295170-1	2009	Sco1 and Sco2 are mitochondrial copper-binding proteins involved in the biogenesis of the Cu(A) site in the cytochrome c oxidase (CcO) subunit Cox2 and in the maintenance of cellular copper homeostasis.	Copper	32-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	143-147
19295170-1	2009	Sco1 and Sco2 are mitochondrial copper-binding proteins involved in the biogenesis of the Cu(A) site in the cytochrome c oxidase (CcO) subunit Cox2 and in the maintenance of cellular copper homeostasis.	Copper	183-189	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	143-147
19266367-1	2009	We performed a phase II trial to test whether a cyclooxygenase (COX-2) inhibitor, celecoxib, added to standard first-line combination chemotherapy (CT) and as maintenance therapy would improve outcomes in extensive-stage (ES) small-cell lung cancer (SCLC).	Celecoxib	82-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-69
19346231-4	2009	TxB(2) formation was studied in platelets treated in vitro with aspirin alone or with a COX-2 inhibitor (NS-398).	Thromboxane B2	0-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-93
19346231-4	2009	TxB(2) formation was studied in platelets treated in vitro with aspirin alone or with a COX-2 inhibitor (NS-398).	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	105-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-93
19384872-2	2009	In inflamed tissues, production of prostaglandins by COX-2 has been proposed to favor Th17 responses indirectly by increasing IL-23 and blocking IL-12 release from APC.	Prostaglandins	35-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-58
19384872-7	2009	Taken together our results indicate that T-cell effector function is a direct target for PGE2 modulation and suggest a novel mechanism by which inhibitors of prostaglandin synthesis, such as COX-2 inhibitors, exert their anti-inflammatory effect.	Dinoprostone	89-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	191-196
19384872-7	2009	Taken together our results indicate that T-cell effector function is a direct target for PGE2 modulation and suggest a novel mechanism by which inhibitors of prostaglandin synthesis, such as COX-2 inhibitors, exert their anti-inflammatory effect.	Prostaglandins	158-171	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	191-196
19208339-3	2009	We examined the functions of HuR and TTP during colon tumorigenesis and their ability to regulate cyclooxygenase (COX-2), a mediator of prostaglandin synthesis that increases in the colon tumor microenvironment.	Prostaglandins	136-149	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-119
19230888-10	2009	CONCLUSION: COX-2 is the primary isoenzyme stimulating overproduction of prostaglandins in the endometrium after the insertion of Cu-IUDs.	Prostaglandins	73-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-17
19360361-0	2009	Nimesulide, a selective COX-2 inhibitor, acts synergistically with ionizing radiation against A549 human lung cancer cells through the activation of caspase-8 and caspase-3.	nimesulide	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
19302827-1	2009	The important athero-protective role of prostacyclin is becoming increasingly evident as recent studies have revealed adverse cardiovascular effects in mice lacking the prostacyclin receptor, in patients taking selective COX-2 inhibitors, and in patients in the presence of a dysfunctional prostacyclin receptor genetic variant.	Epoprostenol	40-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	221-226
19302827-5	2009	Treating VSMC with the prostacyclin analog iloprost induced differentiation (contractile protein expression and contractile morphology), and also up-regulated COX-2 expression, leading to prostacyclin release by VSMC.	vsmc	9-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	159-164
19302827-5	2009	Treating VSMC with the prostacyclin analog iloprost induced differentiation (contractile protein expression and contractile morphology), and also up-regulated COX-2 expression, leading to prostacyclin release by VSMC.	Epoprostenol	23-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	159-164
19302827-5	2009	Treating VSMC with the prostacyclin analog iloprost induced differentiation (contractile protein expression and contractile morphology), and also up-regulated COX-2 expression, leading to prostacyclin release by VSMC.	Iloprost	43-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	159-164
19302827-5	2009	Treating VSMC with the prostacyclin analog iloprost induced differentiation (contractile protein expression and contractile morphology), and also up-regulated COX-2 expression, leading to prostacyclin release by VSMC.	Epoprostenol	188-200	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	159-164
19302827-5	2009	Treating VSMC with the prostacyclin analog iloprost induced differentiation (contractile protein expression and contractile morphology), and also up-regulated COX-2 expression, leading to prostacyclin release by VSMC.	vsmc	212-216	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	159-164
19302827-6	2009	This paracrine prostacyclin release, in turn, promoted differentiation and COX-2 induction in neighboring VSMC that were not exposed to iloprost.	Epoprostenol	15-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
19302827-6	2009	This paracrine prostacyclin release, in turn, promoted differentiation and COX-2 induction in neighboring VSMC that were not exposed to iloprost.	vsmc	106-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
19190238-10	2009	We conclude that basolateral PAR(2) activation induces epithelial chloride secretion that is mediated by cPLA(2), COX-1, COX-2, and the subsequent release of PGE(2).	Chlorides	66-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-126
19191010-7	2009	Curcumin acts as an anti-inflammatory and anti-proliferative agent by causing down regulation of COX-2, iNOS and cyclin D1 in all the three cell lines but to different extent.	Curcumin	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
19193738-7	2009	RESULTS: COX-2 in cultured vascular smooth muscle cells was suppressed by cyclosporine A (CsA); tacrolimus and rapamycin had no effect.	Cyclosporine	74-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	9-14
19193738-7	2009	RESULTS: COX-2 in cultured vascular smooth muscle cells was suppressed by cyclosporine A (CsA); tacrolimus and rapamycin had no effect.	Cyclosporine	90-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	9-14
19193738-13	2009	CONCLUSIONS: Although CsA suppressed COX-2 in cultured vascular smooth muscle cells, systemic prostacyclin was not suppressed by either CsA or tacrolimus in vivo.	Cyclosporine	22-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-42
19437483-5	2009	Treatment with oleic acid, linoleic acid (LA), or linolenic acid increased the expression of iNOS and COX-2 genes and the production of prostaglandin E(2 )and nitric oxide (NO) in RPE, whereas the saturated fatty acid stearic acid had little effect on these genes.	Linoleic Acid	27-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-107
19076306-7	2009	In most of the regions examined, histone H3 acetylation peaked 24 h after UVR and then returned to baseline levels by 72 h. The induction of ATF3, COX2 and MKP1 was blocked in the presence of curcumin at doses that decrease in vivo histone H3 acetylation but not at lower doses that do not affect acetylation levels.	Curcumin	192-200	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-151
19437483-5	2009	Treatment with oleic acid, linoleic acid (LA), or linolenic acid increased the expression of iNOS and COX-2 genes and the production of prostaglandin E(2 )and nitric oxide (NO) in RPE, whereas the saturated fatty acid stearic acid had little effect on these genes.	alpha-Linolenic Acid	50-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-107
21583812-1	2009	The hydro-thermal reaction of CoCO(3) and 4-fluoro-benzoic acid afforded the title Co(II) complex, [Co(C(7)H(4)FO(2))(2)(H(2)O)(2)](n).	coco(3)	30-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-89
19416633-7	2009	Moreover, resveratrol attenuated cyclooxygenase (COX)-2 expression and intracellular Ca2+ levels.	Resveratrol	10-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-55
19416633-10	2009	Resveratrol suppressed the expression of TNF-alpha, IL-6, IL-8 and COX-2 through a decrease in the intracellular levels of Ca2+ and ERK 1/2, as well as activation of NF-kappaB.	Resveratrol	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-72
21583812-1	2009	The hydro-thermal reaction of CoCO(3) and 4-fluoro-benzoic acid afforded the title Co(II) complex, [Co(C(7)H(4)FO(2))(2)(H(2)O)(2)](n).	4-fluorobenzoic acid	42-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-89
19203625-0	2009	Beta-cyclodextrin-cross-linked polymer as solid phase extraction material coupled with inductively coupled plasma mass spectrometry for the analysis of trace Co(II).	betadex	0-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	158-164
19203625-0	2009	Beta-cyclodextrin-cross-linked polymer as solid phase extraction material coupled with inductively coupled plasma mass spectrometry for the analysis of trace Co(II).	Polymers	31-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	158-164
19203625-2	2009	The beta-cyclodextrin cross-linked polymer (beta-CDCP) was synthesized and used as solid phase extraction material (SPE) to separate/pre-concentrate trace cobalt coupled with inductively coupled plasma mass spectrometry (ICP-MS) for the analysis of Co(II).	betadex	4-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	249-255
21583812-1	2009	The hydro-thermal reaction of CoCO(3) and 4-fluoro-benzoic acid afforded the title Co(II) complex, [Co(C(7)H(4)FO(2))(2)(H(2)O)(2)](n).	co(c(7)h	100-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-89
19203625-2	2009	The beta-cyclodextrin cross-linked polymer (beta-CDCP) was synthesized and used as solid phase extraction material (SPE) to separate/pre-concentrate trace cobalt coupled with inductively coupled plasma mass spectrometry (ICP-MS) for the analysis of Co(II).	Polymers	35-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	249-255
19203625-2	2009	The beta-cyclodextrin cross-linked polymer (beta-CDCP) was synthesized and used as solid phase extraction material (SPE) to separate/pre-concentrate trace cobalt coupled with inductively coupled plasma mass spectrometry (ICP-MS) for the analysis of Co(II).	beta-cdcp	44-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	249-255
19203625-3	2009	The method was based on alpha-pyridylazo-beta-naphthol (PAN) as the complexing agent for Co(II)-PAN at neutral condition and the adsorption behavior of Co(II)-PAN on beta-CDCP was studied.	beta-cdcp	166-175	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-158
21583812-2	2009	The Co(II) atom is located on an inversion center and is coordinated by six O atoms from two water mol-ecules and four mu(2)-carboxyl-ate groups of 4-fluoro-benzoate anions, forming a distorted CoO(6) octa-hedron, with Co-O bond lengths in the range 2.071 (2)-2.130 (2) A.	Water	93-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
21583812-2	2009	The Co(II) atom is located on an inversion center and is coordinated by six O atoms from two water mol-ecules and four mu(2)-carboxyl-ate groups of 4-fluoro-benzoate anions, forming a distorted CoO(6) octa-hedron, with Co-O bond lengths in the range 2.071 (2)-2.130 (2) A.	4-fluorobenzoic acid	148-165	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
21583812-2	2009	The Co(II) atom is located on an inversion center and is coordinated by six O atoms from two water mol-ecules and four mu(2)-carboxyl-ate groups of 4-fluoro-benzoate anions, forming a distorted CoO(6) octa-hedron, with Co-O bond lengths in the range 2.071 (2)-2.130 (2) A.	coo(6) octa-hedron	194-212	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
21583812-2	2009	The Co(II) atom is located on an inversion center and is coordinated by six O atoms from two water mol-ecules and four mu(2)-carboxyl-ate groups of 4-fluoro-benzoate anions, forming a distorted CoO(6) octa-hedron, with Co-O bond lengths in the range 2.071 (2)-2.130 (2) A.	carboxyl radical	219-223	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
21583812-4	2009	Each mu-carboxyl-ate group of the 4-fluoro-benzoate anions bridges two symmetry-related Co(II) atoms.	4-fluorobenzoic acid	34-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-94
19301919-0	2009	Tuning the framework topologies of Co(II)-doped Zn(II)-tetrazole-benzoate coordination polymers by ligand modifications: structures and spectral studies.	zn(ii)-tetrazole-benzoate	48-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-41
19333504-0	2009	Coordination polymer based on Cu(II), Co(II) and 4,4"-bipyridine-2,6,2",6"-tetracarboxylate: synthesis, structure and adsorption properties.	Polymers	13-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-44
19301919-0	2009	Tuning the framework topologies of Co(II)-doped Zn(II)-tetrazole-benzoate coordination polymers by ligand modifications: structures and spectral studies.	Polymers	87-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-41
19301919-6	2009	Interestingly, the Co(II) ions were doped into the Zn(II) complexes, as confirmed by their macroscopical colors, inductively coupled plasma (ICP) analysis and UV-visible spectra.	Zinc	51-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-25
19286379-1	2009	We have developed a novel and moderately selective COX-2 inhibitor, imrecoxib, as a new anti-inflammatory drug.	Imrecoxib	68-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-56
19370610-1	2009	BACKGROUND: Parecoxib was the first COX-2 available for parenteral administration, and may, given intravenously or intramuscularly, offer advantages over oral medication when patients have nausea and vomiting or are unable to swallow, such as in the immediate postoperative period.	parecoxib	12-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-41
19046800-0	2009	Nimesulide inhibits IFN-gamma-induced programmed death-1-ligand 1 surface expression in breast cancer cells by COX-2 and PGE2 independent mechanisms.	nimesulide	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	111-116
19319393-0	2009	Ni(II), Co(II), Cu(II), Zn(II) and Na(I) complexes of a hybrid ligand 4"-(4"""-benzo-15-crown-5)-methyloxy-2,2":6",2""-terpyridine.	4'-(4'''-benzo-15-crown-5)-methyloxy-2,2'-6',2''-terpyridine	70-130	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	8-14
19267444-0	2009	Theoretical studies on structures and spectroscopic properties of self-assembled bis(2,4,8,10-tetramethyl-9-methoxycarbonylethyldipyrrin-3-yl)methane with Co(II).	bis(2,4,8,10-tetramethyl-9-methoxycarbonylethyldipyrrin-3-yl)methane	81-149	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	155-161
19046800-4	2009	In the present study, we examined the effects of nimesulide, a selective COX-2 inhibitor, on PD-L1 surface expression in breast cancer cells by flow cytometry.	nimesulide	49-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-78
21556247-3	2009	Raloxifene analogue, Ly117018, a selective estrogen receptor modulator and celecoxib, a specific COX-2 inhibitor have been shown to inhibit breast cancer cell proliferation when used alone in vitro and in vivo.	Celecoxib	75-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
19260662-6	2009	The Co(II) halide complex [N(2)P(2)(tolyl)]CoI (16) is synthesized through an analogues reaction to that of 2.	[n(2)p(2)(tolyl)]coi	26-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
19305892-2	2009	Owing to the high reversibility, the Fe(CN)(6)(3-)/Fe(CN)(6)(4-) ion pair acts as an electron relay at the electrode/electrolyte interface during charge and discharge by coupling in the redox transition of Co(II)/Co(III) in the Co-Al LDH electrode.	fe(cn)	37-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	206-212
19305892-2	2009	Owing to the high reversibility, the Fe(CN)(6)(3-)/Fe(CN)(6)(4-) ion pair acts as an electron relay at the electrode/electrolyte interface during charge and discharge by coupling in the redox transition of Co(II)/Co(III) in the Co-Al LDH electrode.	fe(cn)(6	37-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	206-212
19254941-4	2009	This review describes the utility of AI plus COX-2 inhibitor therapy and discusses the completed and ongoing clinical trials investigating treatment with the AI exemestane and the COX-2 inhibitor celecoxib in the neo-adjuvant and metastatic breast cancer settings.	Celecoxib	196-205	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	180-185
19155154-1	2009	The determination of two sulphur-containing drugs, the COX-2 inhibitors celecoxib and etoricoxib, in the serum and synovial fluid of inflammatory arthritis patients, is described using a sensitive ultra performance liquid chromatography-inductively coupled plasma mass spectroscopy (UPLC/ICPMS) method.	Celecoxib	72-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-60
19155154-3	2009	The two COX-2 inhibitors were extracted from serum and synovial fluid following dilution with acetate buffer (pH 5) and liquid-liquid extraction (LLE) into ethyl acetate.	ethyl acetate	156-169	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	8-13
19358538-10	2009	The first three correspond to [Co(II)DBQ(2-)Co(II)](2+) reduction to [Co(II)DBQ(*3-)Co(II)](+), and oxidation to [Co(III)DBQ(*3-)Co(III)](3+) and [Co(III)DBQ(2-)Co(III)](4+), respectively.	co(ii)dbq(*3-)	70-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-37
19358538-10	2009	The first three correspond to [Co(II)DBQ(2-)Co(II)](2+) reduction to [Co(II)DBQ(*3-)Co(II)](+), and oxidation to [Co(III)DBQ(*3-)Co(III)](3+) and [Co(III)DBQ(2-)Co(III)](4+), respectively.	co(ii)dbq(*3-)	70-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-50
19358538-10	2009	The first three correspond to [Co(II)DBQ(2-)Co(II)](2+) reduction to [Co(II)DBQ(*3-)Co(II)](+), and oxidation to [Co(III)DBQ(*3-)Co(III)](3+) and [Co(III)DBQ(2-)Co(III)](4+), respectively.	co(iii)	129-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-37
19358538-10	2009	The first three correspond to [Co(II)DBQ(2-)Co(II)](2+) reduction to [Co(II)DBQ(*3-)Co(II)](+), and oxidation to [Co(III)DBQ(*3-)Co(III)](3+) and [Co(III)DBQ(2-)Co(III)](4+), respectively.	co(iii)	129-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-50
19358538-10	2009	The first three correspond to [Co(II)DBQ(2-)Co(II)](2+) reduction to [Co(II)DBQ(*3-)Co(II)](+), and oxidation to [Co(III)DBQ(*3-)Co(III)](3+) and [Co(III)DBQ(2-)Co(III)](4+), respectively.	co(iii)	129-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-37
19277614-4	2009	Particular intense ionic lines were observed in the emission spectra as a function of the discharge gas (krypton or argon), such as the Co II 258.033 nm for krypton and the Co II 231.707 nm for argon.	Argon	116-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	136-141
19277614-4	2009	Particular intense ionic lines were observed in the emission spectra as a function of the discharge gas (krypton or argon), such as the Co II 258.033 nm for krypton and the Co II 231.707 nm for argon.	Argon	116-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	173-178
19277614-4	2009	Particular intense ionic lines were observed in the emission spectra as a function of the discharge gas (krypton or argon), such as the Co II 258.033 nm for krypton and the Co II 231.707 nm for argon.	Argon	194-199	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	136-141
19277614-4	2009	Particular intense ionic lines were observed in the emission spectra as a function of the discharge gas (krypton or argon), such as the Co II 258.033 nm for krypton and the Co II 231.707 nm for argon.	Argon	194-199	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	173-178
19416639-3	2009	The cloned stable transfectants with COX-1 or COX-2 exhibited higher expression levels of their corresponding mRNA and proteins, and greater production of PGE(2) upon stimulation with free arachidonic acid or A23187 than the parent cells and the transfectants with vector only.	Prostaglandins E	155-158	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
19342146-1	2009	BACKGROUND: Cyclooxygenase (COX)-2 activity has been said to have a protective effect in asthmatic patients as a result of prostaglandin E(2) production.	Dinoprostone	123-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-34
18768181-0	2009	Association of polymorphisms in cyclooxygenase (COX)-2 with coronary and carotid calcium in the Diabetes Heart Study.	Calcium	81-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-54
18768181-2	2009	Inflammation is a hallmark of the development of atherosclerosis and is mediated by prostaglandins, catalyzed by cyclooxygenase (COX)-2.	Prostaglandins	84-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-135
19174152-3	2009	Delphinidin strongly inhibited TNF-alpha-induced COX-2 expression in JB6 P+ mouse epidermal (JB6 P+) cells, whereas two other major phenolic compounds (resveratrol and gallic acid) did not exert significant inhibitory effects.	delphinidin	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-54
19174152-7	2009	Together these findings suggest that the targeted inhibition of Fyn kinase activity and COX-2 expression by delphinidin contributes to the chemopreventive potential of red wine and berries.	delphinidin	108-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-93
19416639-6	2009	The transfectants with COX-2 were sensitive to exogenous 15-deoxy-Delta(12,14)-PGJ(2) (15d-PGJ(2)) and troglitazone as peroxisome proliferator-activated receptor gamma (PPARgamma) agonists during the maturation phase for restoring the adipogenesis.	Troglitazone	103-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-28
19416639-3	2009	The cloned stable transfectants with COX-1 or COX-2 exhibited higher expression levels of their corresponding mRNA and proteins, and greater production of PGE(2) upon stimulation with free arachidonic acid or A23187 than the parent cells and the transfectants with vector only.	Arachidonic Acid	189-205	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
19416639-8	2009	Taken together, the results suggest that the sustained overexpression of either COX-1 or COX-2 resulted in the interference of adipogenesis program through a PG-independent mechanism with a different mode of action of COX isoforms.	Prostaglandins	158-160	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-94
19416639-3	2009	The cloned stable transfectants with COX-1 or COX-2 exhibited higher expression levels of their corresponding mRNA and proteins, and greater production of PGE(2) upon stimulation with free arachidonic acid or A23187 than the parent cells and the transfectants with vector only.	Calcimycin	209-215	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
19416639-6	2009	The transfectants with COX-2 were sensitive to exogenous 15-deoxy-Delta(12,14)-PGJ(2) (15d-PGJ(2)) and troglitazone as peroxisome proliferator-activated receptor gamma (PPARgamma) agonists during the maturation phase for restoring the adipogenesis.	15-deoxy-delta	57-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-28
19416639-6	2009	The transfectants with COX-2 were sensitive to exogenous 15-deoxy-Delta(12,14)-PGJ(2) (15d-PGJ(2)) and troglitazone as peroxisome proliferator-activated receptor gamma (PPARgamma) agonists during the maturation phase for restoring the adipogenesis.	)-pgj	77-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-28
19416639-6	2009	The transfectants with COX-2 were sensitive to exogenous 15-deoxy-Delta(12,14)-PGJ(2) (15d-PGJ(2)) and troglitazone as peroxisome proliferator-activated receptor gamma (PPARgamma) agonists during the maturation phase for restoring the adipogenesis.	2-(ETHOXYMETHYL)-4-(4-FLUOROPHENYL)-3-[2-(2-HYDROXYPHENOXY)PYRIMIDIN-4-YL]ISOXAZOL-5(2H)-ONE	79-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-28
19336730-1	2009	The Adenoma Prevention with Celecoxib Trial examined the efficacy and safety of the cyclooxygenase (Cox)-2 inhibitor, celecoxib, for sporadic colorectal adenoma prevention in patients at high risk for colorectal cancer.	Celecoxib	118-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-106
19048457-2	2009	Since selective inhibition of COX-2, for example, by celecoxib has been shown to suppress both tumour formation and progression, we investigated COX-2 protein expression in a series of ATC and AST (26 cases each) using immunohistochemistry.	Celecoxib	53-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-35
19336930-3	2009	Although (+/-)-3-methoxynordomesticine possesses weak antimicrobial activity, it inhibits the production of nitric oxide (NO), prostaglandin (PG)E(2), tumor necrosis factor (TNF)-alpha, interleukin (IL)-1 beta and IL-6 and the expression of inducible nitric oxide synthase (iNOS) and cycloxygenase (COX)-2 in macrophages stimulated with LPS in vitro.	(+/-)-3-methoxynordomesticine	9-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	284-305
19407554-1	2009	OBJECTIVE: To examine effects of an inhibitor of cyclooxygenase (COX)-2, NS-398, on the proliferation, apoptosis and invasion characteristics of endometrial cancer cell RL95-2.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	73-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-71
19265384-6	2009	Modification of ZnO NCs with Co(II) resulted in the transfer of photoexcited electrons to the cobalt center where consequent nonradiative recombination, at energies lower than required for PC, was observed via a comparable decrease in both PL and PC activity.	pc	247-249	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-35
19265384-6	2009	Modification of ZnO NCs with Co(II) resulted in the transfer of photoexcited electrons to the cobalt center where consequent nonradiative recombination, at energies lower than required for PC, was observed via a comparable decrease in both PL and PC activity.	Zinc Oxide	16-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-35
18952571-3	2009	The ubiquitous constitutive expression of COX-1 and inducible expression of COX-2 have led to the widely held belief that COX-1 produces homeostatic PGs, while PGs produced by COX-2 are primarily pathophysiological.	Prostaglandins	149-152	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-81
19265384-6	2009	Modification of ZnO NCs with Co(II) resulted in the transfer of photoexcited electrons to the cobalt center where consequent nonradiative recombination, at energies lower than required for PC, was observed via a comparable decrease in both PL and PC activity.	Cobalt	94-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-35
19265384-6	2009	Modification of ZnO NCs with Co(II) resulted in the transfer of photoexcited electrons to the cobalt center where consequent nonradiative recombination, at energies lower than required for PC, was observed via a comparable decrease in both PL and PC activity.	pc	189-191	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-35
19265384-6	2009	Modification of ZnO NCs with Co(II) resulted in the transfer of photoexcited electrons to the cobalt center where consequent nonradiative recombination, at energies lower than required for PC, was observed via a comparable decrease in both PL and PC activity.	pl	240-242	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-35
18956270-2	2009	Co(II), Ni(II) and Cu(II) chloride complexes are square planar, whereas their sulfate complexes have spin-free octahedral geometry.	Sulfates	78-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
18952571-3	2009	The ubiquitous constitutive expression of COX-1 and inducible expression of COX-2 have led to the widely held belief that COX-1 produces homeostatic PGs, while PGs produced by COX-2 are primarily pathophysiological.	Prostaglandins	160-163	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-81
18952571-3	2009	The ubiquitous constitutive expression of COX-1 and inducible expression of COX-2 have led to the widely held belief that COX-1 produces homeostatic PGs, while PGs produced by COX-2 are primarily pathophysiological.	Prostaglandins	160-163	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	176-181
19167421-6	2009	The synergism was: COX-3&gt;COX-2&gt;COX-1 inhibitors, this is particularly interesting since the inhibitor of COX-3, paracetamol, displayed a robust anti-inflammatory activity in an assay of acute and inflammatory pain that mimics inflammatory pain in humans.	Acetaminophen	118-129	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
18926729-1	2009	OBJECTIVE: Recent in vitro studies showed that celecoxib, a selective cyclooxygenase (COX)-2 inhibitor, protects human osteoarthritic cartilage tissue from degeneration.	Celecoxib	47-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-92
18926729-8	2009	In the treated groups prostaglandin-E(2) levels were lower than in the control group, indicating COX-2 inhibition.	Dinoprostone	22-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
19126433-6	2009	In conclusion, colonic longitudinal muscle contraction is augmented by COX-2 activity, most likely via PGE(2) acting at EP(1) receptors.	Prostaglandins E	103-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-76
19107880-11	2009	The inhibition induced by elocalcitol of IL-8 production by BPH cells is accompanied by decreased COX-2 expression and PGE(2) production and by arrest of NF-kappaB p65 nuclear translocation, associated with inhibition of the RhoA/ROCK pathway.	BXL628	26-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-103
19046861-0	2009	Influence of parecoxib (cox-2 inhibitor) in experimental pleurodesis.	parecoxib	13-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
19046861-4	2009	The objective of this study was to determine whether parecoxib (COX-2 inhibitor) affects pleurodesis induced by talc or silver nitrate.	parecoxib	53-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-69
19046861-4	2009	The objective of this study was to determine whether parecoxib (COX-2 inhibitor) affects pleurodesis induced by talc or silver nitrate.	Talc	112-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-69
19269697-1	2009	Cyclooxygenases (COX-1 and COX-2) are key enzymes in the conversion of arachidonic acid to prostaglandins and other lipid mediators.	Arachidonic Acid	71-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-32
19269697-1	2009	Cyclooxygenases (COX-1 and COX-2) are key enzymes in the conversion of arachidonic acid to prostaglandins and other lipid mediators.	Prostaglandins	91-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-32
19293639-3	2009	In this study, quercetin activated AMPK in MCF breast cancer cell lines and HT-29 colon cancer cells, and this activation of AMPK seemed to be closely related to a decrease in COX-2 expression.	Quercetin	15-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	176-181
19293639-4	2009	The application of a COX-2 inhibitor or cox-2-/- cells supported the idea that AMPK is an upstream signal of COX-2, and is required for the anti-proliferatory and pro-apoptotic effects of quercetin.	Quercetin	188-197	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-26
19293639-5	2009	The suppressive or growth inhibitory effects of quercetin on COX-2 were abolished by treating cancer cells with an AMPK inhibitor Compound C. These results suggest that AMPK is crucial to the anti-cancer effect of quercetin and that the AMPK-COX-2 signaling pathway is important in quercetin-mediated cancer control.	Quercetin	48-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-66
19293639-5	2009	The suppressive or growth inhibitory effects of quercetin on COX-2 were abolished by treating cancer cells with an AMPK inhibitor Compound C. These results suggest that AMPK is crucial to the anti-cancer effect of quercetin and that the AMPK-COX-2 signaling pathway is important in quercetin-mediated cancer control.	Quercetin	48-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	242-247
19293639-5	2009	The suppressive or growth inhibitory effects of quercetin on COX-2 were abolished by treating cancer cells with an AMPK inhibitor Compound C. These results suggest that AMPK is crucial to the anti-cancer effect of quercetin and that the AMPK-COX-2 signaling pathway is important in quercetin-mediated cancer control.	Quercetin	214-223	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-66
19293639-5	2009	The suppressive or growth inhibitory effects of quercetin on COX-2 were abolished by treating cancer cells with an AMPK inhibitor Compound C. These results suggest that AMPK is crucial to the anti-cancer effect of quercetin and that the AMPK-COX-2 signaling pathway is important in quercetin-mediated cancer control.	Quercetin	214-223	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-66
18621480-1	2009	Reductive dechlorination of carbon tetrachloride (CT) and 1,1,1-trichloroethane (1,1,1-TCA) by FeS with transition metals (Cu(II), Co(II), and Ni(II)) and hydrosulfide was characterized in this study.	Carbon Tetrachloride	28-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-136
18621480-1	2009	Reductive dechlorination of carbon tetrachloride (CT) and 1,1,1-trichloroethane (1,1,1-TCA) by FeS with transition metals (Cu(II), Co(II), and Ni(II)) and hydrosulfide was characterized in this study.	Carbon Tetrachloride	50-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-136
18621480-1	2009	Reductive dechlorination of carbon tetrachloride (CT) and 1,1,1-trichloroethane (1,1,1-TCA) by FeS with transition metals (Cu(II), Co(II), and Ni(II)) and hydrosulfide was characterized in this study.	1,1,1-trichloroethane	58-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-136
18621480-1	2009	Reductive dechlorination of carbon tetrachloride (CT) and 1,1,1-trichloroethane (1,1,1-TCA) by FeS with transition metals (Cu(II), Co(II), and Ni(II)) and hydrosulfide was characterized in this study.	1,1,1-trichloroethane	81-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-136
18621480-1	2009	Reductive dechlorination of carbon tetrachloride (CT) and 1,1,1-trichloroethane (1,1,1-TCA) by FeS with transition metals (Cu(II), Co(II), and Ni(II)) and hydrosulfide was characterized in this study.	Iron	95-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-136
18621480-5	2009	The rate constants with 10mM Co(II) and Ni(II) were 0.06 and 0.11h(-1), approximately 1.3 and 3.0 times greater than those by FeS alone.	Iron	126-129	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-35
19275264-7	2009	For both catenanes and rotaxanes, removal of the metal ion via reduction under acidic conditions to the more labile Co(II) gave neutral interlocked molecules with well-defined co-conformations stabilized by intercomponent hydrogen bonding.	Catenanes	9-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-122
19275264-7	2009	For both catenanes and rotaxanes, removal of the metal ion via reduction under acidic conditions to the more labile Co(II) gave neutral interlocked molecules with well-defined co-conformations stabilized by intercomponent hydrogen bonding.	Rotaxanes	23-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-122
19275264-7	2009	For both catenanes and rotaxanes, removal of the metal ion via reduction under acidic conditions to the more labile Co(II) gave neutral interlocked molecules with well-defined co-conformations stabilized by intercomponent hydrogen bonding.	Metals	49-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-122
19275264-7	2009	For both catenanes and rotaxanes, removal of the metal ion via reduction under acidic conditions to the more labile Co(II) gave neutral interlocked molecules with well-defined co-conformations stabilized by intercomponent hydrogen bonding.	Hydrogen	222-230	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-122
19276291-13	2009	Urinary PGE-M is a promising biomarker for predicting response to COX-2 inhibition in NSCLC.	Prostaglandins E	8-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-71
19162293-3	2009	This initial action of TCDD is accompanied with the up-regulation of an important inflammation marker, COX-2 mRNA expression within 1h, and by 3h, several other markers become up-regulated.	Polychlorinated Dibenzodioxins	23-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-108
18617357-6	2009	When COX-2 antisense cDNA and COX-2 inhibitor celecoxib were combined, the tumor growth inhibition rate was further increased up to 88.78+/-3.10%.	Celecoxib	46-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-35
18617357-7	2009	These results provide evidence that celecoxib has potential therapeutic effect on bladder cancer, and the joint use of COX-2 antisense cDNA with celecoxib may improve their individual therapeutic effect, especially significantly increase the growth inhibitory effect of COX-2 antisense cDNA.	Celecoxib	145-154	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	270-275
19200742-0	2009	Inhibition of iNOS and COX-2 in human whole blood ex vivo and monocyte-macrophage J774 cells by a new group of aminothiopyrimidone derivatives.	aminothiopyrimidone	111-130	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-28
19200742-1	2009	We tested a series of 11 new aminothiopyrimidones on the activity of inducible nitric oxide synthase (iNOS) and prostaglandin G/H synthase-1 and 2 (COX-1 and COX-2) in the whole human blood and monocyte-macrophage J774 cell line.	aminothiopyrimidones	29-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	158-163
19451093-1	2009	BACKGROUND: We performed a pilot study, looking at the COX-2 inhibitor celecoxib, on newly diagnosed prostate cancer patients in the neo-adjuvant setting using DNA microarray analysis.	Celecoxib	71-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-60
19374865-9	2009	We also demonstrate for the first time that the COX-2 inhibitor rofecoxib can reduce 6-keto PGF1alpha production by both enzymatic inhibition and transcriptional repression.	rofecoxib	64-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-53
19374865-9	2009	We also demonstrate for the first time that the COX-2 inhibitor rofecoxib can reduce 6-keto PGF1alpha production by both enzymatic inhibition and transcriptional repression.	6-Ketoprostaglandin F1 alpha	85-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-53
21582328-1	2009	In the title compound, [Co(C(12)H(15)O(4))(2)(H(2)O)(2)](n), adjacent Co(II) atoms ( symmetry) are bridged by 3-carboxy-adamantane-1-carboxyl-ate anions, forming a chain running along [001].	co(c	24-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-76
19218449-9	2009	These findings support a role for COX-2 in promoting the progression of DCIS to invasive breast carcinomas, and suggest that therapeutic targeting of the NF-kappaB and prostaglandin signaling pathways might be used for the treatment and prevention of breast cancer.	Prostaglandins	168-181	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-39
19298395-4	2009	Inhibition of COX-1 and COX-2 activity in cellular and cell-free assays was assessed by measuring 12(S)-hydroxy-5-cis-8,10-trans-heptadecatrienoic acid and 6-oxo PGF(1alpha) formation.	12(s)-hydroxy-5-cis-8,10-trans-heptadecatrienoic acid	98-151	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
19298395-4	2009	Inhibition of COX-1 and COX-2 activity in cellular and cell-free assays was assessed by measuring 12(S)-hydroxy-5-cis-8,10-trans-heptadecatrienoic acid and 6-oxo PGF(1alpha) formation.	6-oxo pgf	156-165	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
19162293-5	2009	A comparative study among three different human cell lines showed that activation of COX-2 within 1h of action of TCDD is a common feature exhibited by all cell lines.	Polychlorinated Dibenzodioxins	114-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-90
19162293-7	2009	Based on the rapidity of activation of cPLA2 and COX-2, which occurs within 1h of cell exposure to TCDD, when no change in mRNA expression of CYP1A1 has been observed, it is apparent that this unique action of TCDD is carried out through a distinct "nongenomic" pathway which, is clearly discernable from the classical, "genomic" action pathway of the AhR by not requiring the participation of ARNT.	Polychlorinated Dibenzodioxins	99-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-54
19162293-7	2009	Based on the rapidity of activation of cPLA2 and COX-2, which occurs within 1h of cell exposure to TCDD, when no change in mRNA expression of CYP1A1 has been observed, it is apparent that this unique action of TCDD is carried out through a distinct "nongenomic" pathway which, is clearly discernable from the classical, "genomic" action pathway of the AhR by not requiring the participation of ARNT.	Polychlorinated Dibenzodioxins	210-214	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-54
19197941-4	2009	This inhibition was mediated by the COX-2-dependent production of prostaglandin E2 (PGE(2)) and by MSC through EP2 and EP4 inhibitory receptors expressed by Vgamma9Vdelta2 T lymphocytes.	Dinoprostone	66-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-41
19197941-4	2009	This inhibition was mediated by the COX-2-dependent production of prostaglandin E2 (PGE(2)) and by MSC through EP2 and EP4 inhibitory receptors expressed by Vgamma9Vdelta2 T lymphocytes.	Prostaglandins E	84-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-41
18823436-0	2009	Anti-gastric cancer effects of celecoxib, a selective COX-2 inhibitor, through inhibition of Akt signaling.	Celecoxib	31-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-59
20477063-0	2009	Eicosanoids in inflammation and cancer: the role of COX-2.	Eicosanoids	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-57
19212690-5	2009	Application of an EP3 antagonist (ONO-AE3-240) strongly inhibited cell growth in COX-2 and PGE2 high expression cells (Ca9-22) but not in COX-2 and PGE2 low expression cells (HSC4).	ONO-AE3-240	34-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-86
19439810-3	2009	Prostaglandin E(2) and thromboxan A(2) which are a products of two izoformes of cyclooxygenases (COX-1 and COX-2) in macrophages, play an important role in this process.	Prostaglandins E	0-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-112
18656337-10	2009	Inhibitors of ERK1/2 and Akt down-regulated the linoleic-acid-induced increase in COX-2 protein, which also occurred after pretreatment with EGCG.	Linoleic Acid	48-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
18656337-10	2009	Inhibitors of ERK1/2 and Akt down-regulated the linoleic-acid-induced increase in COX-2 protein, which also occurred after pretreatment with EGCG.	epigallocatechin gallate	141-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
18656337-11	2009	Caveolin-1 silencing blocked linoleic-acid-induced phosphorylation of ERK1/2 and protein expression of COX-2, suggesting that specific MAPK signaling is caveolae dependent.	Linoleic Acid	29-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-108
19439810-3	2009	Prostaglandin E(2) and thromboxan A(2) which are a products of two izoformes of cyclooxygenases (COX-1 and COX-2) in macrophages, play an important role in this process.	thromboxan a	23-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-112
19439810-8	2009	Monocytes were differentiated to macrophages and cultured with 30 muM CLAs or linoleic acid for 48 h. The COX-1 and COX-2 products - PGE(2) and TXB(2), were measured by ELISA method.	Prostaglandins E	133-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-121
19439810-12	2009	Significant change in COX-2 expression in cells cultured with trans-10, cis-12 CLA (in macrophages obtained from peripheral blood) was observed.	trans-10,cis-12-conjugated linoleic acid	62-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-27
19067254-1	2009	The polycation poly(ethylenimine) (PEI) was used to deliver the plasmids coding for various combinations of caspases to Cox-2 overexpressing cancer cell lines.	Polyethyleneimine	15-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-125
19122175-2	2009	We have addressed whether the induction of COX-2-dependent prostanoids in endothelial cells by LSS plays a role in restraining endothelial tumor necrosis factor (TNF)-alpha generation, a proatherogenic cytokine, through the induction of heme oxygenase-1 (HO)-1, an antioxidant enzyme.	Prostaglandins	59-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
19067254-1	2009	The polycation poly(ethylenimine) (PEI) was used to deliver the plasmids coding for various combinations of caspases to Cox-2 overexpressing cancer cell lines.	Polyethyleneimine	35-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-125
19642502-7	2009	In this patient meloxicam treatment, a preferential selective COX-2 inhibitor, leaded to a significant reduction in the number of colorectal polyps during 3 years follow up.	Meloxicam	16-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
19576016-1	2009	OBJECTIVE: To investigate the role of COX-2 inhibitor celecoxib in enhancing the lethal effects of bleomycin in Tca8113 cell line.	Celecoxib	54-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-43
19576016-1	2009	OBJECTIVE: To investigate the role of COX-2 inhibitor celecoxib in enhancing the lethal effects of bleomycin in Tca8113 cell line.	Bleomycin	99-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-43
19122175-7	2009	The finding that LSS-dependent reduction of TNF-alpha generation and HO-1 induction were abrogated by the selective inhibitor of COX-2 NS-398, the nonselective COX inhibitor aspirin, or the specific prostacyclin receptor (IP) antagonist RO3244794 illuminates the central role played by LSS-induced COX-2-dependent prostacyclin in restraining endothelial inflammation.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	135-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-134
19122175-7	2009	The finding that LSS-dependent reduction of TNF-alpha generation and HO-1 induction were abrogated by the selective inhibitor of COX-2 NS-398, the nonselective COX inhibitor aspirin, or the specific prostacyclin receptor (IP) antagonist RO3244794 illuminates the central role played by LSS-induced COX-2-dependent prostacyclin in restraining endothelial inflammation.	RO3244794	237-246	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-134
19122175-7	2009	The finding that LSS-dependent reduction of TNF-alpha generation and HO-1 induction were abrogated by the selective inhibitor of COX-2 NS-398, the nonselective COX inhibitor aspirin, or the specific prostacyclin receptor (IP) antagonist RO3244794 illuminates the central role played by LSS-induced COX-2-dependent prostacyclin in restraining endothelial inflammation.	Epoprostenol	199-211	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	298-303
19122175-10	2009	These findings suggest that inhibition of COX-2-dependent prostacyclin might contribute to acceleration of atherogenesis in patients taking traditional nonsteroidal antiinflammatory drugs (NSAIDs) and NSAIDs selective for COX-2 through downregulation of HO-1, which halts TNF-alpha generation in human endothelial cells.	Epoprostenol	58-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47
19214306-2	2009	Both C-Cl bonds of CH(2)Cl(2) are readily activated by CoCl(2) and metallic Zn allowing quantitative methylation of phosphines; unprecedented zwitterionic Co(ii) and Zn(ii) intermediates have been characterized which display alpha-metallated phosphoniums.	Carbon	5-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	155-161
19122175-10	2009	These findings suggest that inhibition of COX-2-dependent prostacyclin might contribute to acceleration of atherogenesis in patients taking traditional nonsteroidal antiinflammatory drugs (NSAIDs) and NSAIDs selective for COX-2 through downregulation of HO-1, which halts TNF-alpha generation in human endothelial cells.	Epoprostenol	58-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	222-227
19214306-2	2009	Both C-Cl bonds of CH(2)Cl(2) are readily activated by CoCl(2) and metallic Zn allowing quantitative methylation of phosphines; unprecedented zwitterionic Co(ii) and Zn(ii) intermediates have been characterized which display alpha-metallated phosphoniums.	Carbon	5-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	158-160
19214306-2	2009	Both C-Cl bonds of CH(2)Cl(2) are readily activated by CoCl(2) and metallic Zn allowing quantitative methylation of phosphines; unprecedented zwitterionic Co(ii) and Zn(ii) intermediates have been characterized which display alpha-metallated phosphoniums.	Methylene Chloride	19-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	155-161
19214306-2	2009	Both C-Cl bonds of CH(2)Cl(2) are readily activated by CoCl(2) and metallic Zn allowing quantitative methylation of phosphines; unprecedented zwitterionic Co(ii) and Zn(ii) intermediates have been characterized which display alpha-metallated phosphoniums.	Methylene Chloride	19-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	158-160
19214306-2	2009	Both C-Cl bonds of CH(2)Cl(2) are readily activated by CoCl(2) and metallic Zn allowing quantitative methylation of phosphines; unprecedented zwitterionic Co(ii) and Zn(ii) intermediates have been characterized which display alpha-metallated phosphoniums.	cobaltous chloride	55-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	158-160
19214306-2	2009	Both C-Cl bonds of CH(2)Cl(2) are readily activated by CoCl(2) and metallic Zn allowing quantitative methylation of phosphines; unprecedented zwitterionic Co(ii) and Zn(ii) intermediates have been characterized which display alpha-metallated phosphoniums.	Phosphines	116-126	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	155-161
19214306-2	2009	Both C-Cl bonds of CH(2)Cl(2) are readily activated by CoCl(2) and metallic Zn allowing quantitative methylation of phosphines; unprecedented zwitterionic Co(ii) and Zn(ii) intermediates have been characterized which display alpha-metallated phosphoniums.	Phosphines	116-126	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	158-160
19214306-2	2009	Both C-Cl bonds of CH(2)Cl(2) are readily activated by CoCl(2) and metallic Zn allowing quantitative methylation of phosphines; unprecedented zwitterionic Co(ii) and Zn(ii) intermediates have been characterized which display alpha-metallated phosphoniums.	phosphoniums	242-254	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	155-161
19214306-2	2009	Both C-Cl bonds of CH(2)Cl(2) are readily activated by CoCl(2) and metallic Zn allowing quantitative methylation of phosphines; unprecedented zwitterionic Co(ii) and Zn(ii) intermediates have been characterized which display alpha-metallated phosphoniums.	phosphoniums	242-254	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	158-160
19462652-1	2009	The reaction of CoX2 (X = Cl, Br, NO3) with KTp(Ph2) in tetrahydrofuran (THF) yields the half-sandwich compounds [Tp(Ph2)CoX] (X = Cl 1, Br 2, NO3 3).	tetrahydrofuran	73-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-20
19462652-1	2009	The reaction of CoX2 (X = Cl, Br, NO3) with KTp(Ph2) in tetrahydrofuran (THF) yields the half-sandwich compounds [Tp(Ph2)CoX] (X = Cl 1, Br 2, NO3 3).	Bromine	30-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-20
19462652-1	2009	The reaction of CoX2 (X = Cl, Br, NO3) with KTp(Ph2) in tetrahydrofuran (THF) yields the half-sandwich compounds [Tp(Ph2)CoX] (X = Cl 1, Br 2, NO3 3).	KTP compound	44-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-20
19462652-1	2009	The reaction of CoX2 (X = Cl, Br, NO3) with KTp(Ph2) in tetrahydrofuran (THF) yields the half-sandwich compounds [Tp(Ph2)CoX] (X = Cl 1, Br 2, NO3 3).	tetrahydrofuran	56-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-20
21582077-2	2009	The Co(II) cation has an octa-hedral coordination environment provided by an NO(5) donor set.	no(5)	77-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
18996358-3	2009	The most salient features of the inflammatory action of TCDD are that its triggering events, such as the rapid increase in intracellular Ca(2+) concentration, enzymatic activation of cytosolic phospholipase A2 (cPLA2) and that of Cox-2 are taking place through the nongenomic action of the ligand-activated AHR.	Polychlorinated Dibenzodioxins	56-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	230-235
19128154-1	2009	A new tetranuclear cobalt(II) molecular square in which adjacent Co(II) centers are linked by a mu(2)-bridging oxygen atom and a N-N bridge along the edges of the square has been designed for single-molecule magnets (SMMs) with high anisotropy barriers.	Cobalt(2+)	19-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-71
19128155-5	2009	The two terminal Co(II) ions contain a facial coordination environment (3N, 3O) comprising three imino nitrogen atoms and three phenolate oxygen atoms.	3o	76-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-23
19128155-5	2009	The two terminal Co(II) ions contain a facial coordination environment (3N, 3O) comprising three imino nitrogen atoms and three phenolate oxygen atoms.	Nitrogen	103-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-23
19128155-5	2009	The two terminal Co(II) ions contain a facial coordination environment (3N, 3O) comprising three imino nitrogen atoms and three phenolate oxygen atoms.	Oxygen	138-144	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-23
19133742-5	2009	The cyclic voltammogram of 1 showed irreversible redox waves at -0.57 V and +0.16 V versus Ag/AgCl in DMF, which are ascribed to the Co(III) and Co(II) redox couple.	silver chloride	94-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-151
19133742-5	2009	The cyclic voltammogram of 1 showed irreversible redox waves at -0.57 V and +0.16 V versus Ag/AgCl in DMF, which are ascribed to the Co(III) and Co(II) redox couple.	Dimethylformamide	102-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-151
19234885-5	2009	We investigated whether celecoxib, a selective Cox-2 inhibitor, increases prosthesis migration in total knee replacement (TKR).	Celecoxib	24-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
19190378-3	2009	In (I), two independent Co(II) ions are six-coordinated through N(3)O(3) donor sets in slightly distorted octahedral geometries provided by two carboxylate and three pyridine ligands, and one water molecule.	n(3)o(3)	64-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-30
19190378-3	2009	In (I), two independent Co(II) ions are six-coordinated through N(3)O(3) donor sets in slightly distorted octahedral geometries provided by two carboxylate and three pyridine ligands, and one water molecule.	carboxylate	144-155	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-30
19157881-5	2009	The obtained data show, that the central carbocyclic or heterocyclic ring system as found in many COX-2 inhibitors can be replaced by a central 1,2,3-triazole unit without losing COX-2 inhibition potency and selectivity.	Triazoles	144-158	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-103
19190378-3	2009	In (I), two independent Co(II) ions are six-coordinated through N(3)O(3) donor sets in slightly distorted octahedral geometries provided by two carboxylate and three pyridine ligands, and one water molecule.	pyridine	166-174	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-30
19190378-3	2009	In (I), two independent Co(II) ions are six-coordinated through N(3)O(3) donor sets in slightly distorted octahedral geometries provided by two carboxylate and three pyridine ligands, and one water molecule.	Water	192-197	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-30
19250217-6	2009	Furthermore, curcumin or, more potently, the isoxazole analogue, produced early reductions in the amounts of relevant gene transcripts that were diverse (i.e., they were relative to Bcl-2 and Bcl-X(L) in MCF-7 and the inhibitory of apoptosis proteins and COX-2 in MCF-7R) in the two cell lines.	Curcumin	13-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	255-260
19250217-6	2009	Furthermore, curcumin or, more potently, the isoxazole analogue, produced early reductions in the amounts of relevant gene transcripts that were diverse (i.e., they were relative to Bcl-2 and Bcl-X(L) in MCF-7 and the inhibitory of apoptosis proteins and COX-2 in MCF-7R) in the two cell lines.	Isoxazoles	45-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	255-260
18656337-7	2009	Pretreatment with EGCG blocked fatty-acid-induced caveolin-1 and COX-2 expression in a time- and concentration-dependent manner.	epigallocatechin gallate	18-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-70
18656337-7	2009	Pretreatment with EGCG blocked fatty-acid-induced caveolin-1 and COX-2 expression in a time- and concentration-dependent manner.	Fatty Acids	31-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-70
18487053-0	2009	Synthesis and biological evaluation of a library of resveratrol analogues as inhibitors of COX-1, COX-2 and NF-kappaB.	Resveratrol	52-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-103
18487053-1	2009	Resveratrol (4,3",5"-trihydroxystilbene) is a naturally occurring antioxidant that inhibits cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2) and the transcription factor NF-kappaB.	Resveratrol	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	136-141
18487053-1	2009	Resveratrol (4,3",5"-trihydroxystilbene) is a naturally occurring antioxidant that inhibits cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2) and the transcription factor NF-kappaB.	4,3",5"-trihydroxystilbene	13-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	136-141
19157881-6	2009	The high COX-2 inhibition potency of some 1,2,3-triazoles having a vicinal diaryl substitution pattern along with their ease in synthesis through versatile Ru(II)-catalyzed click chemistry make this class of compounds interesting candidates for further design and synthesis of highly selective and potent COX-2 inhibitors.	1,2,3-triazoles	42-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	9-14
19157881-6	2009	The high COX-2 inhibition potency of some 1,2,3-triazoles having a vicinal diaryl substitution pattern along with their ease in synthesis through versatile Ru(II)-catalyzed click chemistry make this class of compounds interesting candidates for further design and synthesis of highly selective and potent COX-2 inhibitors.	1,2,3-triazoles	42-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	305-310
19157881-6	2009	The high COX-2 inhibition potency of some 1,2,3-triazoles having a vicinal diaryl substitution pattern along with their ease in synthesis through versatile Ru(II)-catalyzed click chemistry make this class of compounds interesting candidates for further design and synthesis of highly selective and potent COX-2 inhibitors.	ru(ii)	156-162	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	9-14
19157881-6	2009	The high COX-2 inhibition potency of some 1,2,3-triazoles having a vicinal diaryl substitution pattern along with their ease in synthesis through versatile Ru(II)-catalyzed click chemistry make this class of compounds interesting candidates for further design and synthesis of highly selective and potent COX-2 inhibitors.	ru(ii)	156-162	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	305-310
19236238-1	2009	COX-2 is upregulated at an early stage in colorectal carcinogenesis and generates prostaglandins, which promote cancer cell proliferation, impair apoptosis and enhance angiogenesis, promoting tumour growth and metastasis.	Prostaglandins	82-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
18579258-3	2009	In complex 1, Co(II) ions possess a tetrahedral coordination environment composed of O2S2 donor atoms while its Cu(II) and Zn(II) counterparts 2 and 3, respectively, reveal a six coordinate octahedral structure, defined by the O2S2 donors from the macrocyclic ring and two chloride ions.	o2s2	85-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-20
18579258-3	2009	In complex 1, Co(II) ions possess a tetrahedral coordination environment composed of O2S2 donor atoms while its Cu(II) and Zn(II) counterparts 2 and 3, respectively, reveal a six coordinate octahedral structure, defined by the O2S2 donors from the macrocyclic ring and two chloride ions.	o2s2	227-231	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-20
18579258-3	2009	In complex 1, Co(II) ions possess a tetrahedral coordination environment composed of O2S2 donor atoms while its Cu(II) and Zn(II) counterparts 2 and 3, respectively, reveal a six coordinate octahedral structure, defined by the O2S2 donors from the macrocyclic ring and two chloride ions.	Chlorides	273-281	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-20
19073628-0	2009	Putting the vasoactive effects of COX-2-derived prostanoids into clinical perspective.	Prostaglandins	48-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-39
18838483-1	2009	We aimed at evaluating the relative contribution of cyclooxygenase (COX) -1 and COX-2 to the synthesis of prostacyclin in endothelial cells under static conditions in the presence or absence of exogenous arachidonic acid and/or altered intracellular redox balance.	Epoprostenol	106-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-85
18838483-2	2009	Selective inhibitors of either COX-1 (SC560 and FR122047) or COX-2 (SC236) concentration dependently (1-300 nM) reduced basal and interleukin (IL) -1beta-induced prostacyclin production in human umbilical vein endothelial cells by 70% or more; compound selectivity was confirmed using a whole-blood assay (IC(50) COX-1/COX-2: 13 nM/930 nM for SC-560; 9 microM/457 nM for SC-236).	4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide	68-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-66
18838483-2	2009	Selective inhibitors of either COX-1 (SC560 and FR122047) or COX-2 (SC236) concentration dependently (1-300 nM) reduced basal and interleukin (IL) -1beta-induced prostacyclin production in human umbilical vein endothelial cells by 70% or more; compound selectivity was confirmed using a whole-blood assay (IC(50) COX-1/COX-2: 13 nM/930 nM for SC-560; 9 microM/457 nM for SC-236).	4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide	68-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	319-324
18838483-2	2009	Selective inhibitors of either COX-1 (SC560 and FR122047) or COX-2 (SC236) concentration dependently (1-300 nM) reduced basal and interleukin (IL) -1beta-induced prostacyclin production in human umbilical vein endothelial cells by 70% or more; compound selectivity was confirmed using a whole-blood assay (IC(50) COX-1/COX-2: 13 nM/930 nM for SC-560; 9 microM/457 nM for SC-236).	Epoprostenol	162-174	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-66
18838483-2	2009	Selective inhibitors of either COX-1 (SC560 and FR122047) or COX-2 (SC236) concentration dependently (1-300 nM) reduced basal and interleukin (IL) -1beta-induced prostacyclin production in human umbilical vein endothelial cells by 70% or more; compound selectivity was confirmed using a whole-blood assay (IC(50) COX-1/COX-2: 13 nM/930 nM for SC-560; 9 microM/457 nM for SC-236).	SC 560	343-349	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-66
18838483-2	2009	Selective inhibitors of either COX-1 (SC560 and FR122047) or COX-2 (SC236) concentration dependently (1-300 nM) reduced basal and interleukin (IL) -1beta-induced prostacyclin production in human umbilical vein endothelial cells by 70% or more; compound selectivity was confirmed using a whole-blood assay (IC(50) COX-1/COX-2: 13 nM/930 nM for SC-560; 9 microM/457 nM for SC-236).	4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide	371-377	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-66
18838483-5	2009	Both isoforms appear to contribute to basal prostacyclin production by endothelial cells, with COX-2 providing the hydroperoxide tone required for COX-1 activity.	Hydrogen Peroxide	115-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-100
19236238-3	2009	Conversely, NSAIDs including aspirin inhibit COX-2 and, therefore, have anti-neoplastic properties.	Aspirin	29-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-50
19100343-7	2009	KHBJ-9B and 3 combined triterpenoids potently inhibited the release of proteoglycan and type II collagen in a dose dependent manner without cytotoxicity in IL-1beta-treated human cartilage explants culture, whereas its single major compounds (betulin, pimaradienoic acid and betulinic acid) and COX-2 inhibitor (NS398) showed little inhibition even at high concentrations.	KHBJ-9B	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	295-300
19100343-7	2009	KHBJ-9B and 3 combined triterpenoids potently inhibited the release of proteoglycan and type II collagen in a dose dependent manner without cytotoxicity in IL-1beta-treated human cartilage explants culture, whereas its single major compounds (betulin, pimaradienoic acid and betulinic acid) and COX-2 inhibitor (NS398) showed little inhibition even at high concentrations.	triterpenoids	23-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	295-300
19203564-1	2009	A novel topical ophthalmic formulation of the preferential COX-2 inhibitor meloxicam has recently been developed.	Meloxicam	75-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-64
19179955-1	2009	In this second article we describe the more interesting pharmacological interactions in dental practice based on the prescription of analgesic narcotics, paracetamol and non-selective non-steroid anti-inflammatory drugs (NSAI) (which inhibit cyclooxigenase 1 -COX 1- and cyclooxigenase 2 -COX 2-) and selective NSAIs (COX 2 inhibitors).	Acetaminophen	154-165	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	289-294
19048430-0	2009	Synthesis, spectral characterization and microbiological studies of Co(II), Ni(II) and Cu(II) complexes with some novel 20-membered macrocyclic hydrazino-1,2,4-triazole Schiff bases.	cu(ii)	87-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-74
19048430-0	2009	Synthesis, spectral characterization and microbiological studies of Co(II), Ni(II) and Cu(II) complexes with some novel 20-membered macrocyclic hydrazino-1,2,4-triazole Schiff bases.	hydrazino-1,2,4-triazole schiff bases	144-181	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-74
19048430-1	2009	A series of Co(II), Ni(II) and Cu(II) complexes have been synthesized by template condensation of 2,6-diformyl-4-methylphenol and 3-substituted-4-amino-5-hydrazino-1,2,4-triazole with CoCl(2).6H(2)O, NiCl(2).6H(2)O and CuCl(2).2H(2)O chlorides in 2 + 2+2 molar ratio in ethanol.	cu(ii)	31-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-18
19048430-1	2009	A series of Co(II), Ni(II) and Cu(II) complexes have been synthesized by template condensation of 2,6-diformyl-4-methylphenol and 3-substituted-4-amino-5-hydrazino-1,2,4-triazole with CoCl(2).6H(2)O, NiCl(2).6H(2)O and CuCl(2).2H(2)O chlorides in 2 + 2+2 molar ratio in ethanol.	2,6-diformyl-4-methylphenol	98-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-18
19048430-1	2009	A series of Co(II), Ni(II) and Cu(II) complexes have been synthesized by template condensation of 2,6-diformyl-4-methylphenol and 3-substituted-4-amino-5-hydrazino-1,2,4-triazole with CoCl(2).6H(2)O, NiCl(2).6H(2)O and CuCl(2).2H(2)O chlorides in 2 + 2+2 molar ratio in ethanol.	3-substituted-4-amino-5-hydrazino-1,2,4-triazole	130-178	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-18
19048430-1	2009	A series of Co(II), Ni(II) and Cu(II) complexes have been synthesized by template condensation of 2,6-diformyl-4-methylphenol and 3-substituted-4-amino-5-hydrazino-1,2,4-triazole with CoCl(2).6H(2)O, NiCl(2).6H(2)O and CuCl(2).2H(2)O chlorides in 2 + 2+2 molar ratio in ethanol.	cocl(2).6h(2)o	184-198	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-18
19048430-1	2009	A series of Co(II), Ni(II) and Cu(II) complexes have been synthesized by template condensation of 2,6-diformyl-4-methylphenol and 3-substituted-4-amino-5-hydrazino-1,2,4-triazole with CoCl(2).6H(2)O, NiCl(2).6H(2)O and CuCl(2).2H(2)O chlorides in 2 + 2+2 molar ratio in ethanol.	nicl(2).6h(2)o	200-214	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-18
19048430-1	2009	A series of Co(II), Ni(II) and Cu(II) complexes have been synthesized by template condensation of 2,6-diformyl-4-methylphenol and 3-substituted-4-amino-5-hydrazino-1,2,4-triazole with CoCl(2).6H(2)O, NiCl(2).6H(2)O and CuCl(2).2H(2)O chlorides in 2 + 2+2 molar ratio in ethanol.	cucl(2).2h(2)o chlorides	219-243	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-18
19048430-1	2009	A series of Co(II), Ni(II) and Cu(II) complexes have been synthesized by template condensation of 2,6-diformyl-4-methylphenol and 3-substituted-4-amino-5-hydrazino-1,2,4-triazole with CoCl(2).6H(2)O, NiCl(2).6H(2)O and CuCl(2).2H(2)O chlorides in 2 + 2+2 molar ratio in ethanol.	Ethanol	270-277	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-18
19048430-4	2009	Elemental analyses suggest the complexes to have 2:1 stoichiometry of the type [M(2)LX(2)] 2H(2)O (M = Co(II) &amp; Cu(II), L = L(I)-L(IV) and X = Cl) and [Ni(2)LX(2)2H(2)O] 2H(2)O.	(2)lx(2)	81-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-109
19048430-4	2009	Elemental analyses suggest the complexes to have 2:1 stoichiometry of the type [M(2)LX(2)] 2H(2)O (M = Co(II) &amp; Cu(II), L = L(I)-L(IV) and X = Cl) and [Ni(2)LX(2)2H(2)O] 2H(2)O.	Deuterium	91-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-109
19298218-4	2009	The first approach is the development of selective inhibitors of the enzyme cyclooxygenase (COX)-2, the inducible isoform of the prostaglandin G/H synthetase enzyme.	Prostaglandins	129-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-98
19298218-6	2009	Selective inhibitors of COX-2 will suppress prostaglandin synthesis at the sites of inflammation, but they will not interfere with the activity of COX-1, in tissues like the GI tract.	Prostaglandins	44-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
19161453-3	2009	COX-1 and COX-2 activities in heparinized feline whole blood samples were induced with calcium ionophore and lipopolysaccharide, respectively.	Calcium	87-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
19161453-4	2009	Inhibition of thromboxane B2 provided a marker of both COX-1 and COX-2 activities and a nonlinear parametric mixed effects modelling approach was used to establish the pharmacodynamic parameters describing this inhibition.	Thromboxane B2	14-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-70
19161453-8	2009	Based on a clinically recommended dosage regimen of 2 mg/kg, it was predicted that the corresponding mean robenacoxib blood concentration over the first 12 h after drug administration corresponded to 5% inhibition of COX-1 and 90% inhibition of COX-2.	robenacoxib	106-117	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	245-250
18951238-4	2009	Compounds 4-(3-Phenyl-4-cyano-1H-pyrazol-1-yl)benzenesulfonamide 9a and 4-(3-Tolyl-4-cyano-1H-pyrazol-1-yl)benzenesulfonamide 9b were not only found to be the most active dual anti-inflammatory antimicrobial agents in the present study with good safety margin and minimal ulcerogenic effect but also exhibited good selective inhibitory activity towards COX-2.	4-(3-phenyl-4-cyano-1h-pyrazol-1-yl)benzenesulfonamide	10-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	353-358
18951238-4	2009	Compounds 4-(3-Phenyl-4-cyano-1H-pyrazol-1-yl)benzenesulfonamide 9a and 4-(3-Tolyl-4-cyano-1H-pyrazol-1-yl)benzenesulfonamide 9b were not only found to be the most active dual anti-inflammatory antimicrobial agents in the present study with good safety margin and minimal ulcerogenic effect but also exhibited good selective inhibitory activity towards COX-2.	4-(3-tolyl-4-cyano-1h-pyrazol-1-yl)benzenesulfonamide	72-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	353-358
19084589-0	2009	Induction of COX-2 in human airway cells by manganese: role of PI3K/PKB, p38 MAPK, PKCs, Src, and glutathione depletion.	Manganese	44-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
19084589-2	2009	COX-2 is a protein involved in biosynthesis of inflammatory prostaglandins.	Prostaglandins	60-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
19084589-4	2009	In this study, the effect of manganese-chloride (manganese) on COX-2 expression in A549 human lung epithelial cells was investigated.	manganese chloride	29-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-68
19084589-4	2009	In this study, the effect of manganese-chloride (manganese) on COX-2 expression in A549 human lung epithelial cells was investigated.	Manganese	29-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-68
19084589-5	2009	Treatment with manganese induced COX-2 at both protein and mRNA levels that were due to COX-2 transcriptional activation.	Manganese	15-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-38
19084589-5	2009	Treatment with manganese induced COX-2 at both protein and mRNA levels that were due to COX-2 transcriptional activation.	Manganese	15-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-93
19084589-7	2009	Importantly, the manganese-induced COX-2 expression was suppressed by treatment with the inhibitor of p38 MAPK (SB203580), PI3K/PKB (LY294002), PKCs (GO6983, GF109203X, Rottlerin), Src (PP1), or the thiol-containing compound (NAC).	Manganese	17-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40
19084589-7	2009	Importantly, the manganese-induced COX-2 expression was suppressed by treatment with the inhibitor of p38 MAPK (SB203580), PI3K/PKB (LY294002), PKCs (GO6983, GF109203X, Rottlerin), Src (PP1), or the thiol-containing compound (NAC).	SB 203580	112-120	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40
19236750-4	2009	The results showed that the expression of COX-2, MMP-2 and MMP-9 decreased in dose- and time-dependent manners after treating with As(2)O(3).	as(2)o	131-137	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47
19236750-6	2009	In conclusion, As(2)O(3) inhibits expressions of COX-2, MMP-2 and MMP-9 in K562 and SGC7901 cells, suggesting that As(2)O(3) inhibits tumor development through its effect on angiogenesis involved in solid and hematologic malignancies.	hippuric acid	17-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-54
19236750-6	2009	In conclusion, As(2)O(3) inhibits expressions of COX-2, MMP-2 and MMP-9 in K562 and SGC7901 cells, suggesting that As(2)O(3) inhibits tumor development through its effect on angiogenesis involved in solid and hematologic malignancies.	(2)o(3)	17-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-54
19028575-2	2009	The model takes into account key features of the complex catalytic mechanism of cyclooxygenase-1, converting arachidonic acid to prostaglandin PGH(2), and includes the description of the enzyme interaction with various types of NSAIDs (reversible/irreversible, non-selective and selective to COX-1/COX-2).	Arachidonic Acid	109-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	298-303
19028575-2	2009	The model takes into account key features of the complex catalytic mechanism of cyclooxygenase-1, converting arachidonic acid to prostaglandin PGH(2), and includes the description of the enzyme interaction with various types of NSAIDs (reversible/irreversible, non-selective and selective to COX-1/COX-2).	prostaglandin pgh	129-146	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	298-303
19096033-5	2009	Endothelium-dependent contractions were triggered by acetylcholine (ACh) after inhibition of nitric oxide production and they were abolished by COX-2 but not COX-1 inhibitors or by thromboxane-prostanoid receptor antagonists.	Acetylcholine	53-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	144-149
19096033-5	2009	Endothelium-dependent contractions were triggered by acetylcholine (ACh) after inhibition of nitric oxide production and they were abolished by COX-2 but not COX-1 inhibitors or by thromboxane-prostanoid receptor antagonists.	Acetylcholine	68-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	144-149
19096033-5	2009	Endothelium-dependent contractions were triggered by acetylcholine (ACh) after inhibition of nitric oxide production and they were abolished by COX-2 but not COX-1 inhibitors or by thromboxane-prostanoid receptor antagonists.	Nitric Oxide	93-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	144-149
19096033-10	2009	Human renal arteries also showed thromboxane-prostanoid receptor-mediated ACh- or PGF(2alpha)-induced contractions and COX-2-dependent release of PGF(2alpha).	Prostaglandins F	146-149	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-124
19096033-11	2009	The present study demonstrates that PGF(2alpha), derived from COX-2, which is localized primarily in the endothelium, is the most likely EDCF underlying endothelium-dependent, thromboxane-prostanoid receptor-mediated contractions to ACh in hamster aortae.	Prostaglandins F	36-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
19096033-11	2009	The present study demonstrates that PGF(2alpha), derived from COX-2, which is localized primarily in the endothelium, is the most likely EDCF underlying endothelium-dependent, thromboxane-prostanoid receptor-mediated contractions to ACh in hamster aortae.	Acetylcholine	233-236	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
19567186-9	2009	Celecoxib, the selective COX-2 inhibitor, reduces the expression of COX-2 protein and promotes cell apoptosis induced by CSE in vascular endothelial cells.	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-30
19567186-9	2009	Celecoxib, the selective COX-2 inhibitor, reduces the expression of COX-2 protein and promotes cell apoptosis induced by CSE in vascular endothelial cells.	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-73
19179955-1	2009	In this second article we describe the more interesting pharmacological interactions in dental practice based on the prescription of analgesic narcotics, paracetamol and non-selective non-steroid anti-inflammatory drugs (NSAI) (which inhibit cyclooxigenase 1 -COX 1- and cyclooxigenase 2 -COX 2-) and selective NSAIs (COX 2 inhibitors).	Acetaminophen	154-165	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	318-323
19101538-0	2009	Inhibition of both COX-1 and COX-2 and resulting decrease in the level of prostaglandins E2 is responsible for non-steroidal anti-inflammatory drug (NSAID)-dependent exacerbation of colitis.	Dinoprostone	74-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34
19101538-6	2009	The intestinal level of PGE(2) dramatically decreased in response to administration of COX-1- and COX-2-selective inhibitors, and exogenously administered PGE(2) suppressed the exacerbation of colitis by NSAIDs.	Prostaglandins E	24-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-103
19101538-9	2009	This study provides evidence that inhibition of both COX-1 and COX-2 and the resulting dramatic decrease in the intestinal level of PGE(2) is responsible for NSAID-dependent exacerbation of DSS-induced colitis.	Prostaglandins E	132-135	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-68
18495336-11	2009	The ozonated GAC was also evaluated for the adsorption of Co(II) species from single solute and Cu(II)-Co(II) binary mixture solutions.	cu(ii)	96-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-64
18495336-11	2009	The ozonated GAC was also evaluated for the adsorption of Co(II) species from single solute and Cu(II)-Co(II) binary mixture solutions.	cu(ii)	96-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-109
18805632-7	2009	NO-ASA induced COX-2 expression starting 90 min after p21(cip-1) was induced.	nitroxy-butyl-acetylsalicylic acid	0-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-20
18805632-8	2009	When COX-2 expression was knocked down using siRNA against cox-2, the expression of p21(cip-1) was induced by NO-ASA, regardless of the level of expression of COX-2, suggesting a marginal, if any, role for COX-2 in the growth inhibitory effect of NO-ASA.	Aspirin	113-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	5-10
18805632-8	2009	When COX-2 expression was knocked down using siRNA against cox-2, the expression of p21(cip-1) was induced by NO-ASA, regardless of the level of expression of COX-2, suggesting a marginal, if any, role for COX-2 in the growth inhibitory effect of NO-ASA.	Aspirin	113-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-64
18805632-8	2009	When COX-2 expression was knocked down using siRNA against cox-2, the expression of p21(cip-1) was induced by NO-ASA, regardless of the level of expression of COX-2, suggesting a marginal, if any, role for COX-2 in the growth inhibitory effect of NO-ASA.	Aspirin	250-253	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	5-10
18805632-8	2009	When COX-2 expression was knocked down using siRNA against cox-2, the expression of p21(cip-1) was induced by NO-ASA, regardless of the level of expression of COX-2, suggesting a marginal, if any, role for COX-2 in the growth inhibitory effect of NO-ASA.	Aspirin	250-253	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-64
19056264-1	2009	3H-1,2-Dithiole-3-thiones substituted with a 3,5-di-tert-butyl-4-hydroxyphenyl (DTBHP) or a 3,5-di-tert-butyl-4-methoxyphenyl group at the C5 position were prepared and their ability to inhibit the cyclooxygenase isoenzymes, COX-1 and COX-2 was evaluated.	1,2-dithiol-3-thione	0-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	235-240
19056264-3	2009	Docking studies of the two compounds into the COX-1 and -2 active sites showed that the methyl ether could only fit in the COX-2 active site whereas the phenol could be docked into both COX-1 and -2.	Phenol	153-159	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-128
19064102-1	2009	This work reports the determination of trace Co(II) by adsorptive stripping voltammetry on disposable three-electrode cells with on-chip metal-film electrodes.	Metals	137-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-50
19064102-4	2009	Co(II) was determined by square wave adsorptive stripping voltammetry (SWAdSV) after complexation with dimethylglyoxime (DMG).	dimethylglyoxime	103-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
19064102-4	2009	Co(II) was determined by square wave adsorptive stripping voltammetry (SWAdSV) after complexation with dimethylglyoxime (DMG).	dimethylglyoxime	121-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
19093868-0	2009	Curcumin exerts antidifferentiation effect through AMPKalpha-PPAR-gamma in 3T3-L1 adipocytes and antiproliferatory effect through AMPKalpha-COX-2 in cancer cells.	Curcumin	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-145
19093868-4	2009	Stimulation of AMPK by curcumin resulted in the down-regulation of PPAR (peroxisome proliferator-activated receptor)-gamma in 3T3-L1 adipocytes and the decrease in COX-2 in MCF-7 cells.	Curcumin	23-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	164-169
19093868-7	2009	Regulation of AMPK and its downstream targets such as PPAR-gamma, Mapkinases, and COX-2 by curcumin appears to be important in controlling adipocytes and cancerous cells.	Curcumin	91-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
19014992-7	2009	By utilizing both antioxidants or specific COX inhibitors, it was shown that COX-2 upregulation was dependent on ROS, specifically, O2(-).	Reactive Oxygen Species	113-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-82
19014992-7	2009	By utilizing both antioxidants or specific COX inhibitors, it was shown that COX-2 upregulation was dependent on ROS, specifically, O2(-).	Oxygen	132-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-82
19072169-3	2009	Relative gas-phase stabilities of the double-stranded oligodeoxynucleotide (ODN)-M(2+) complexes were found to follow the order Mn(II) &gt; Fe(II) &gt; Co(II) &gt; Ni(II) &gt; Zn(II) &gt; Cu(II).	Oligodeoxyribonucleotides	54-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-158
19072169-3	2009	Relative gas-phase stabilities of the double-stranded oligodeoxynucleotide (ODN)-M(2+) complexes were found to follow the order Mn(II) &gt; Fe(II) &gt; Co(II) &gt; Ni(II) &gt; Zn(II) &gt; Cu(II).	Oligodeoxyribonucleotides	76-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-158
19081971-6	2009	All complexes could be seen as model compounds for the active site of the enzyme ACMSD, where the Co(II) complexes reflected the structural flexibility found in case of two histidine (His177 and His228) residues found in the active site of the enzyme.	Histidine	173-182	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-104
19099070-1	2009	Three Co(II) isomers assembled from D-, or L-, or DL-camphorate together with achiral isonicotinate exhibit a clear relationship between chirality and helicity even though chiral molecules are not in the backbone of the helix: the absolute sense of helix made of achiral components is controlled by chains of metal and enantiopure chiral ligands running perpendicular to helix in two enantiomeric forms.	d-, or l-, or dl-camphorate	36-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	6-12
19099070-1	2009	Three Co(II) isomers assembled from D-, or L-, or DL-camphorate together with achiral isonicotinate exhibit a clear relationship between chirality and helicity even though chiral molecules are not in the backbone of the helix: the absolute sense of helix made of achiral components is controlled by chains of metal and enantiopure chiral ligands running perpendicular to helix in two enantiomeric forms.	Metals	309-314	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	6-12
19053335-5	2009	The double aqua bridges were found to mediate ferromagnetic interactions along the chains in the Co(II)-containing polymer, whereas intrachain antiferromagnetic interactions are present in the Fe(II)-, Fe(III)-, and Mn(II)-containing polymers.	Polymers	115-122	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
18712436-1	2009	BACKGROUND: In 2005 we reported a study on the efficacy of the preoperative use of the selective COX-2 inhibitor celecoxib (Celebrex) for reducing both postoperative pain and opioid requirements in patients undergoing bilateral subpectoral breast augmentation.	Celecoxib	113-122	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
18712436-1	2009	BACKGROUND: In 2005 we reported a study on the efficacy of the preoperative use of the selective COX-2 inhibitor celecoxib (Celebrex) for reducing both postoperative pain and opioid requirements in patients undergoing bilateral subpectoral breast augmentation.	Celecoxib	124-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
19938227-7	2009	Furthermore, resveratrol inhibited extracellular signal-regulated kinase (ERK) and p38 MAPK phosphorylation, IkappaBalpha degradation, NF-kappaB activation and cyclooxygenase (COX)-2 expression, which suggest that resveratrol inhibits IL-8 secretion by blocking MAPK phosphorylation and NF-kappaB activation.	Resveratrol	13-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	160-182
19938227-7	2009	Furthermore, resveratrol inhibited extracellular signal-regulated kinase (ERK) and p38 MAPK phosphorylation, IkappaBalpha degradation, NF-kappaB activation and cyclooxygenase (COX)-2 expression, which suggest that resveratrol inhibits IL-8 secretion by blocking MAPK phosphorylation and NF-kappaB activation.	Resveratrol	214-225	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	160-182
18849602-9	2009	In cultured human mesangial cells we also demonstrated that nicotine increases COX-2 expression and activity and that COX-2 mediates mesangial cell proliferation in response to nicotine.	Nicotine	60-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-84
18849602-9	2009	In cultured human mesangial cells we also demonstrated that nicotine increases COX-2 expression and activity and that COX-2 mediates mesangial cell proliferation in response to nicotine.	Nicotine	177-185	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-123
19225232-9	2009	Valsartan blocked the AII-induced mRNA expression of proinflammatory genes (i.e. MCP-1, LIF and COX-2) maintained in normal and high glucose.	Valsartan	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-101
19225232-11	2009	While simvastatin inhibited expression of some mRNAs encoding chemokines/cytokines, it enhanced expression of mRNA encoding COX-2, a key mediator of inflammation.	Simvastatin	6-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	124-129
18617679-5	2009	Pretreatment with N-acetylcysteine (NAC) or EUK-134, in a dose-dependent manner, attenuated PM-induced ROS production, COX-2 expression, and IL-6 release.	Acetylcysteine	18-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-124
18617679-5	2009	Pretreatment with N-acetylcysteine (NAC) or EUK-134, in a dose-dependent manner, attenuated PM-induced ROS production, COX-2 expression, and IL-6 release.	Acetylcysteine	36-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-124
19575683-5	2009	Patients with aspirin sensitivity are often able to tolerate selective COX-2 inhibitors.	Aspirin	14-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-76
19183882-9	2009	In addition, NS398 enhanced SNP-induced COX-2, even though NS398 effectively inhibited SNP-mediated PGE(2) production.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	13-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
18952595-8	2009	Our results support three potentially useful ideas: (i) the concept that ROS are a critical component of the action of chemopreventive agents; (ii) the notion that COX-2 may not be an ideal target for chemoprevention and (iii) the possibility that COX-2 may be overexpressed in cancer cells due to their state of oxidative stress.	Reactive Oxygen Species	73-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	248-253
19160097-9	2009	NS-398 dose-dependently decreased the levels of COX-2 mRNA, COX-2 protein, nuclear NF-kappaB protein and production of PGF(1alpha) and increased the cytoplasmic IkappaB protein.	Nitrogen	0-2	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-53
19160097-9	2009	NS-398 dose-dependently decreased the levels of COX-2 mRNA, COX-2 protein, nuclear NF-kappaB protein and production of PGF(1alpha) and increased the cytoplasmic IkappaB protein.	Nitrogen	0-2	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-65
19390242-2	2009	A major transcriptional promoter of the malignant phenotype, HIF-1alpha, has been observed to be regulated by the COX-2 product PGE2.	Dinoprostone	128-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-119
19390242-4	2009	In contrast HIF-1alpha expression could be detected in COX-2- silenced cells in response to the hypoxia-mimetic agent CoCl(2) and hypoxia.	cobaltous chloride	118-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-60
19345936-5	2009	Herein, we tested a variety of Cox-1/Cox-2 non-selective NSAIDs, namely ibuprofen, tylenol, aspirin and naproxen and report that they blunt IgM and IgG synthesis in stimulated human peripheral blood mononuclear cells (PBMC).	Ibuprofen	72-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-42
19345936-5	2009	Herein, we tested a variety of Cox-1/Cox-2 non-selective NSAIDs, namely ibuprofen, tylenol, aspirin and naproxen and report that they blunt IgM and IgG synthesis in stimulated human peripheral blood mononuclear cells (PBMC).	Acetaminophen	83-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-42
19345936-5	2009	Herein, we tested a variety of Cox-1/Cox-2 non-selective NSAIDs, namely ibuprofen, tylenol, aspirin and naproxen and report that they blunt IgM and IgG synthesis in stimulated human peripheral blood mononuclear cells (PBMC).	Aspirin	92-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-42
19345936-5	2009	Herein, we tested a variety of Cox-1/Cox-2 non-selective NSAIDs, namely ibuprofen, tylenol, aspirin and naproxen and report that they blunt IgM and IgG synthesis in stimulated human peripheral blood mononuclear cells (PBMC).	Naproxen	104-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-42
19940361-6	2009	CONCLUSIONS: COX-2 inhibitors prevent chemoresistance development in breast cancer cells by inhibiting P-gp expression and function by a mechanism that involves PGH2 generation and NF-kappaB activation.	Prostaglandin H2	161-165	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
19940363-5	2009	RESULTS: Down-regulation of COX-2 by celecoxib led to up-regulation of E-cadherin mRNA and protein levels in conventional gastric cancer cell lines, whereas expression was down regulated in the early-onset gastric cancer (EOGC) cell line.	Celecoxib	37-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
19266521-0	2009	Hydrogen-atom transfer in reactions of organic radicals with [Co(II)(por)]* (por = porphyrinato) and in subsequent addition of [Co(H)(por)] to olefins.	Hydrogen	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
19266521-0	2009	Hydrogen-atom transfer in reactions of organic radicals with [Co(II)(por)]* (por = porphyrinato) and in subsequent addition of [Co(H)(por)] to olefins.	Alkenes	143-150	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
19266521-3	2009	These reactions are relevant to catalytic chain transfer (CCT) in radical polymerization of olefins mediated by [Co(II)(por)](*), the formation and homolysis of organo-cobalt complexes that mediate living radical polymerization of vinyl acetate, and cobalt-mediated hydrogenation of olefins.	Alkenes	92-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-118
19266521-3	2009	These reactions are relevant to catalytic chain transfer (CCT) in radical polymerization of olefins mediated by [Co(II)(por)](*), the formation and homolysis of organo-cobalt complexes that mediate living radical polymerization of vinyl acetate, and cobalt-mediated hydrogenation of olefins.	vinyl acetate	231-244	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-118
19266521-3	2009	These reactions are relevant to catalytic chain transfer (CCT) in radical polymerization of olefins mediated by [Co(II)(por)](*), the formation and homolysis of organo-cobalt complexes that mediate living radical polymerization of vinyl acetate, and cobalt-mediated hydrogenation of olefins.	Alkenes	283-290	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-118
19266521-4	2009	Hydrogen transfer from (*)C(CH(3))(2)CN to [Co(II)(por)](*) proceeds via a single transition state that has structural features resembling the products [Co(H)(por)] and CH(2)=C(CH(3))CN.	Hydrogen	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-49
19266521-10	2009	The computed energies obtained for the hydrogen-atom transfer reactions from (*)C(CH(3))(2)CN to [Co(II)(por)](*) and from [Co(H)(por)] to olefins, as well as the organo-cobalt bond homolysis energies correspond well with the experimental observations.	Hydrogen	39-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-103
19301335-2	2009	Depending on its affinity for the anions present, it can be isolated in its Co(III) (3)Co(II) (3) (m=3; e.g., 1(ClO(4))(3)) and Co(III) (2)Co(II) (4) (m=2; e.g., 1(BF(4))(2)n H(2)O) oxidation states.	perchlorate	112-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-93
19308980-1	2009	The complex [Co(II)(tmhd)(2)] (4; tmhd = 2,2,6,6-tetramethylhepta-3,5-dionato) has been investigated as a mediator for controlled radical polymerization of vinyl acetate (VAc) and compared with the analogue [Co(II)(acac)(2)] (1; acac = acetylacetonato).	dipivaloylmethane	20-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-19
19308980-1	2009	The complex [Co(II)(tmhd)(2)] (4; tmhd = 2,2,6,6-tetramethylhepta-3,5-dionato) has been investigated as a mediator for controlled radical polymerization of vinyl acetate (VAc) and compared with the analogue [Co(II)(acac)(2)] (1; acac = acetylacetonato).	dipivaloylmethane	20-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	208-214
19308980-1	2009	The complex [Co(II)(tmhd)(2)] (4; tmhd = 2,2,6,6-tetramethylhepta-3,5-dionato) has been investigated as a mediator for controlled radical polymerization of vinyl acetate (VAc) and compared with the analogue [Co(II)(acac)(2)] (1; acac = acetylacetonato).	dipivaloylmethane	34-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-19
19308980-1	2009	The complex [Co(II)(tmhd)(2)] (4; tmhd = 2,2,6,6-tetramethylhepta-3,5-dionato) has been investigated as a mediator for controlled radical polymerization of vinyl acetate (VAc) and compared with the analogue [Co(II)(acac)(2)] (1; acac = acetylacetonato).	dipivaloylmethane	34-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	208-214
19308980-1	2009	The complex [Co(II)(tmhd)(2)] (4; tmhd = 2,2,6,6-tetramethylhepta-3,5-dionato) has been investigated as a mediator for controlled radical polymerization of vinyl acetate (VAc) and compared with the analogue [Co(II)(acac)(2)] (1; acac = acetylacetonato).	vinyl acetate	156-169	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-19
19308980-1	2009	The complex [Co(II)(tmhd)(2)] (4; tmhd = 2,2,6,6-tetramethylhepta-3,5-dionato) has been investigated as a mediator for controlled radical polymerization of vinyl acetate (VAc) and compared with the analogue [Co(II)(acac)(2)] (1; acac = acetylacetonato).	vinyl acetate	171-174	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-19
19308980-1	2009	The complex [Co(II)(tmhd)(2)] (4; tmhd = 2,2,6,6-tetramethylhepta-3,5-dionato) has been investigated as a mediator for controlled radical polymerization of vinyl acetate (VAc) and compared with the analogue [Co(II)(acac)(2)] (1; acac = acetylacetonato).	acac)	215-220	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-19
19308980-1	2009	The complex [Co(II)(tmhd)(2)] (4; tmhd = 2,2,6,6-tetramethylhepta-3,5-dionato) has been investigated as a mediator for controlled radical polymerization of vinyl acetate (VAc) and compared with the analogue [Co(II)(acac)(2)] (1; acac = acetylacetonato).	acetylacetone	215-219	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-19
19308980-1	2009	The complex [Co(II)(tmhd)(2)] (4; tmhd = 2,2,6,6-tetramethylhepta-3,5-dionato) has been investigated as a mediator for controlled radical polymerization of vinyl acetate (VAc) and compared with the analogue [Co(II)(acac)(2)] (1; acac = acetylacetonato).	acetylacetonato	236-251	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-19
19308980-5	2009	The polymer molecular weight evolves linearly with conversion in accordance with the expected values for one chain per Co atom when DT is the predominant mechanism and also during the pure OMRP process; however, observation of stagnating molecular weights at long reaction times with concomitant breakdown of the first-order rate law for monomer consumption indicates a competitive chain-transfer process catalyzed by an increasing amount of Co(II).	Polymers	4-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	442-448
19308980-7	2009	The reversal of relative effective OMRP rate constants k(eff) (4&gt;1 in the absence of external donors, 4&lt;1 in their presence) is rationalized through competitive steric effects on Co(III)-C and Co(II)-L bond strengths.	co(iii)	185-192	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	199-205
19101961-1	2009	The crystal structures and magnetic properties of two new Co(II) molecular magnets, [Co(N(3))(2)(btzb)] (1) and [Co(N(3))(2)(btze)(2)] (2), are described and discussed (btzb=1,4-bis(tetrazol-1-yl)butane and btze=1,4-bis(tetrazol-1-yl)ethane).	co(n(3))	85-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-64
19101961-1	2009	The crystal structures and magnetic properties of two new Co(II) molecular magnets, [Co(N(3))(2)(btzb)] (1) and [Co(N(3))(2)(btze)(2)] (2), are described and discussed (btzb=1,4-bis(tetrazol-1-yl)butane and btze=1,4-bis(tetrazol-1-yl)ethane).	btzb)	97-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-64
19101961-1	2009	The crystal structures and magnetic properties of two new Co(II) molecular magnets, [Co(N(3))(2)(btzb)] (1) and [Co(N(3))(2)(btze)(2)] (2), are described and discussed (btzb=1,4-bis(tetrazol-1-yl)butane and btze=1,4-bis(tetrazol-1-yl)ethane).	co(n(3))(2)(btze)(	113-131	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-64
19101961-1	2009	The crystal structures and magnetic properties of two new Co(II) molecular magnets, [Co(N(3))(2)(btzb)] (1) and [Co(N(3))(2)(btze)(2)] (2), are described and discussed (btzb=1,4-bis(tetrazol-1-yl)butane and btze=1,4-bis(tetrazol-1-yl)ethane).	btzb	97-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-64
19101961-1	2009	The crystal structures and magnetic properties of two new Co(II) molecular magnets, [Co(N(3))(2)(btzb)] (1) and [Co(N(3))(2)(btze)(2)] (2), are described and discussed (btzb=1,4-bis(tetrazol-1-yl)butane and btze=1,4-bis(tetrazol-1-yl)ethane).	1,4-bis(tetrazol-1-yl)butane	174-202	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-64
19101961-1	2009	The crystal structures and magnetic properties of two new Co(II) molecular magnets, [Co(N(3))(2)(btzb)] (1) and [Co(N(3))(2)(btze)(2)] (2), are described and discussed (btzb=1,4-bis(tetrazol-1-yl)butane and btze=1,4-bis(tetrazol-1-yl)ethane).	btze	125-129	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-64
19101961-1	2009	The crystal structures and magnetic properties of two new Co(II) molecular magnets, [Co(N(3))(2)(btzb)] (1) and [Co(N(3))(2)(btze)(2)] (2), are described and discussed (btzb=1,4-bis(tetrazol-1-yl)butane and btze=1,4-bis(tetrazol-1-yl)ethane).	1,4-bis(tetrazol-1-yl)ethane	212-240	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-64
19938885-0	2009	Low-dose aspirin reduces gastro-protective properties of COX-2 selective inhibitors.	Aspirin	9-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-62
19938885-2	2009	With this case we emphasize that the potential of the stomach-protecting properties of COX-2 selective inhibitors may be reduced in patients who are simultaneously taking aspirin.	Aspirin	171-178	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-92
19938885-3	2009	We also review several pathogenic mechanisms that have been advanced by animal studies to explain the finding that a COX-2 selective inhibitor plus low-dose aspirin leads to an ulcer rate near that of a dual COX-1/COX-2 inhibitor alone.	Aspirin	157-164	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	214-219
19067731-8	2009	Heterogeneity in the way patients respond to aspirin and clopidogrel may in part reflect variation in cyclooxygenase (COX)-1, COX-2, glycoprotein (GP) Ib alpha, GP Ia/IIa, GP IIb/IIIa, UGT1A6*2, P2Y(1), P2Y(12), CYP2C9, CYP3A4 and CYP3A5 genotypes.	Clopidogrel	57-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-131
19241124-2	2009	We previously reported that the invasiveness of human oral squamous cell carcinoma (OSCC) cell lines NA and HSC-4 was suppressed by treatment with either NS-398, a selective COX-2 inhibitor, or COX-2 antisense oligonucleotide (AS).	Oligonucleotides	210-225	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	194-199
19327236-1	2009	BACKGROUND AND OBJECTIVE: The selective COX-2 inhibitor celecoxib is widely used to treat pain and inflammation in rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis.	Celecoxib	56-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
19668566-5	2009	The unique chemical structure of bromfenac makes it both a potent inhibitor of the COX-2 enzyme and a highly lipophilic molecule that rapidly penetrates to produce early and sustained drug levels in all ocular tissues.	bromfenac	33-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
19013259-13	2009	CONCLUSIONS: That there was a decrease for the celecoxib over the placebo group adds to the body of evidence that relates COX-2 specific inhibitors and cancer incidence.	Celecoxib	47-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-127
19444759-1	2009	Prostaglandin (PG) E(2), which exerts its actions via the PG receptors EP1-4, is produced from arachidonic acid by cyclooxygenase (COX)-1 and COX-2.	Dinoprostone	0-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	142-147
19444759-1	2009	Prostaglandin (PG) E(2), which exerts its actions via the PG receptors EP1-4, is produced from arachidonic acid by cyclooxygenase (COX)-1 and COX-2.	Arachidonic Acid	95-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	142-147
19444759-3	2009	The cells were cultured with 0, 10, or 100 U/mL IL-1beta with or without 1 muM celecoxib, a specific inhibitor of COX-2, for up to 28 days.	Celecoxib	79-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-119
19114773-7	2009	COX-2 inhibition still seems preferred option, as the effects observed with aspirin (the only chemopreventive agent with some apparent future) are more profound only in tumors and cells expressing COX-2.	Aspirin	76-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
19114773-7	2009	COX-2 inhibition still seems preferred option, as the effects observed with aspirin (the only chemopreventive agent with some apparent future) are more profound only in tumors and cells expressing COX-2.	Aspirin	76-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	197-202
19114773-10	2009	By inhibiting COX-2 or other tumorigenic targets, NSAIDs, especially aspirin or new aspirin derivates, may prevent colon cancer in selected populations.	Aspirin	69-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
19114773-10	2009	By inhibiting COX-2 or other tumorigenic targets, NSAIDs, especially aspirin or new aspirin derivates, may prevent colon cancer in selected populations.	Aspirin	84-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
19519446-13	2009	The inhibitory effects of curcumin on major inflammatory mechanisms like COX-2, LOX, TNF-alpha, IFN-gamma, NF-kappaB and its unrivalled safety profile suggest that it has bright prospects in the treatment of IBD.	Curcumin	26-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-78
19754418-5	2009	mPGES-1 is functionally coupled to COX-2 being responsible for excessive PGE(2) generation connected to pathologies and current knowledge suggests key roles of mPGES-1 in inflammation, pain, fever, atherosclerosis, and tumorigenesis.	Prostaglandins E	1-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40
21701610-10	2009	Acetylsalicylic acid appears to diminish the benefit of COX-2s over tNSAIDs.	Aspirin	0-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-61
19960991-6	2009	Patients with low PG synthesis in body increases likelihood of gastropathy as to reception of non-selective COX inhibitors, and at receiving selective COX-2 inhibitors.	pg	18-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-156
19899409-1	2009	PURPOSE: The aim of the study was to assess whether COX-2 expression in epithelial ovarian carcinoma (EOC) tissue can distinguish between platin-sensitive and platin-resistant tumors.	Platinum	138-144	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-57
19899409-1	2009	PURPOSE: The aim of the study was to assess whether COX-2 expression in epithelial ovarian carcinoma (EOC) tissue can distinguish between platin-sensitive and platin-resistant tumors.	Platinum	159-165	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-57
19862936-0	2009	COX-2 inhibition attenuates cough reflex sensitivity to inhaled capsaicin in patients with asthma.	Capsaicin	64-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
19862936-6	2009	PATIENTS AND METHODS: The effect of etodolac, a potent COX-2 inhibitor, on cough response to inhaled capsaicin was examined in 17 patients with stable asthma in a randomized, placebo-controlled crossover study.	Etodolac	36-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-60
18945810-2	2009	Because COX-2 is the rate-limiting enzyme for proinflammatory prostaglandins, this study investigated the combinatorial inhibitory role of glucocorticoid receptor (GR) in COX-2 gene induction in macrophages and sought to identify the molecular mechanisms for that inhibition.	Prostaglandins	62-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	8-13
19116880-5	2009	COX-2 promoter activity was determined by luciferase assays, protein expression by Western blotting, and secretion of prostaglandin E(2) (PGE(2)) by ELISA.	Dinoprostone	118-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
19116880-5	2009	COX-2 promoter activity was determined by luciferase assays, protein expression by Western blotting, and secretion of prostaglandin E(2) (PGE(2)) by ELISA.	Prostaglandins E	138-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
19232171-2	2009	OBJECTIVE: To study the expression of COX-2 and its possible relationship with the maximum standardized uptake value (SUV) in FDG-PET, and EGFR, p16 and MIB1 expression in patients with NSCLC.	Fluorodeoxyglucose F18	126-129	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-43
18667354-0	2009	Synthesis, structural characterization, thermal and electrochemical studies of the N,N"-bis[(3,4-dichlorophenyl)methylidene]cyclohexane-1,4-diamine and its Cu(II), Co(II) and Ni(II) metal complexes.	n,n"-bis[(3,4-dichlorophenyl)methylidene]cyclohexane-1,4-diamine	83-147	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	164-170
18667354-0	2009	Synthesis, structural characterization, thermal and electrochemical studies of the N,N"-bis[(3,4-dichlorophenyl)methylidene]cyclohexane-1,4-diamine and its Cu(II), Co(II) and Ni(II) metal complexes.	cu(ii)	156-162	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	164-170
18667354-1	2009	In this study, N,N"-bis[(3,4-dichlorophenyl)methylidene]cyclohexane-1,4-diamine (L) and its Cu(II), Co(II) and Ni(II) complexes were prepared and characterized by the analytical and spectroscopic methods.	n,n"-bis[(3,4-dichlorophenyl)methylidene]cyclohexane-1,4-diamine	15-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-106
19084589-7	2009	Importantly, the manganese-induced COX-2 expression was suppressed by treatment with the inhibitor of p38 MAPK (SB203580), PI3K/PKB (LY294002), PKCs (GO6983, GF109203X, Rottlerin), Src (PP1), or the thiol-containing compound (NAC).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	133-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40
19084589-7	2009	Importantly, the manganese-induced COX-2 expression was suppressed by treatment with the inhibitor of p38 MAPK (SB203580), PI3K/PKB (LY294002), PKCs (GO6983, GF109203X, Rottlerin), Src (PP1), or the thiol-containing compound (NAC).	2-(1-(3-dimethylaminopropyl)-5-methoxyindol-3-yl)-3-(1H-indol-3-yl)maleimide	150-156	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40
19084589-7	2009	Importantly, the manganese-induced COX-2 expression was suppressed by treatment with the inhibitor of p38 MAPK (SB203580), PI3K/PKB (LY294002), PKCs (GO6983, GF109203X, Rottlerin), Src (PP1), or the thiol-containing compound (NAC).	bisindolylmaleimide I	158-167	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40
19084589-7	2009	Importantly, the manganese-induced COX-2 expression was suppressed by treatment with the inhibitor of p38 MAPK (SB203580), PI3K/PKB (LY294002), PKCs (GO6983, GF109203X, Rottlerin), Src (PP1), or the thiol-containing compound (NAC).	rottlerin	169-178	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40
19084589-7	2009	Importantly, the manganese-induced COX-2 expression was suppressed by treatment with the inhibitor of p38 MAPK (SB203580), PI3K/PKB (LY294002), PKCs (GO6983, GF109203X, Rottlerin), Src (PP1), or the thiol-containing compound (NAC).	Sulfhydryl Compounds	199-204	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40
19084589-9	2009	Induction of COX-2 by manganese was also seen in different human airway cells, including H292 (bronchial) or Hep2 (laryngeal).	Manganese	22-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
19084589-10	2009	These results collectively suggest that manganese induces COX-2 by transcriptional up-regulation in human airway cells and the induction appears to be cooperatively mediated via multiple signaling pathways and GSH depletion.	Manganese	40-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
18499296-3	2009	Based on these observations, we assessed the efficacy and tolerability of the combination chemotherapy consisting of carboplatin and paclitaxel with meloxicam, a selective COX-2 inhibitor.	Meloxicam	149-158	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	172-177
19399184-2	2009	Current data suggest that resistance to treatment in HER2 cancers may be a consequence of NF-kappaB overexpression and increased COX2-derived prostaglandin E2 (PGE(2)).	Dinoprostone	142-158	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-133
19399184-2	2009	Current data suggest that resistance to treatment in HER2 cancers may be a consequence of NF-kappaB overexpression and increased COX2-derived prostaglandin E2 (PGE(2)).	Prostaglandins E	160-163	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-133
19399184-3	2009	Conjugated linoleic acid (CLA) has been shown to have anti-tumor properties and to inhibit NF-kappaB activity and COX2.	Linoleic Acid	11-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-118
19399184-3	2009	Conjugated linoleic acid (CLA) has been shown to have anti-tumor properties and to inhibit NF-kappaB activity and COX2.	Linoleic Acids, Conjugated	26-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-118
19399184-12	2009	These data add to previous reports of an anti-tumor effect of t10c12 CLA and suggest an effect on the HER2 oncogene that may be through CLA mediated downregulation of COX2-derived PGE(2).	Prostaglandins E	180-183	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	167-171
19700850-1	2009	Methods for the removal of radiocobalt from an ethylenediaminetetraacetic acid (EDTA) complex of Co(II) (aqueous solution containing 10 microM Co(II) and 10 microM or 50 microM EDTA traced with (57)Co) are presented.	Edetic Acid	47-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-103
19700850-1	2009	Methods for the removal of radiocobalt from an ethylenediaminetetraacetic acid (EDTA) complex of Co(II) (aqueous solution containing 10 microM Co(II) and 10 microM or 50 microM EDTA traced with (57)Co) are presented.	Edetic Acid	80-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-103
19074288-1	2008	Cyclooxygenase (COX-1/COX-2)-catalyzed eicosanoid formation plays a key role in inflammation-associated diseases.	Eicosanoids	39-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-27
19074288-3	2008	Here we find that vitamin E forms differentially inhibit COX-2-catalyzed prostaglandin E(2) in IL-1beta-stimulated A549 cells without affecting COX-2 expression, showing the relative potency of gamma-tocotrienol approximately delta-tocopherol &gt; gamma-tocopherol &gt;&gt; alpha- or beta-tocopherol.	Vitamin E	18-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-62
19074288-3	2008	Here we find that vitamin E forms differentially inhibit COX-2-catalyzed prostaglandin E(2) in IL-1beta-stimulated A549 cells without affecting COX-2 expression, showing the relative potency of gamma-tocotrienol approximately delta-tocopherol &gt; gamma-tocopherol &gt;&gt; alpha- or beta-tocopherol.	Dinoprostone	73-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-62
19074288-3	2008	Here we find that vitamin E forms differentially inhibit COX-2-catalyzed prostaglandin E(2) in IL-1beta-stimulated A549 cells without affecting COX-2 expression, showing the relative potency of gamma-tocotrienol approximately delta-tocopherol &gt; gamma-tocopherol &gt;&gt; alpha- or beta-tocopherol.	plastochromanol 8	194-211	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-62
19074288-3	2008	Here we find that vitamin E forms differentially inhibit COX-2-catalyzed prostaglandin E(2) in IL-1beta-stimulated A549 cells without affecting COX-2 expression, showing the relative potency of gamma-tocotrienol approximately delta-tocopherol &gt; gamma-tocopherol &gt;&gt; alpha- or beta-tocopherol.	delta-tocopherol	226-242	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-62
19074288-3	2008	Here we find that vitamin E forms differentially inhibit COX-2-catalyzed prostaglandin E(2) in IL-1beta-stimulated A549 cells without affecting COX-2 expression, showing the relative potency of gamma-tocotrienol approximately delta-tocopherol &gt; gamma-tocopherol &gt;&gt; alpha- or beta-tocopherol.	gamma-Tocopherol	248-264	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-62
19074288-3	2008	Here we find that vitamin E forms differentially inhibit COX-2-catalyzed prostaglandin E(2) in IL-1beta-stimulated A549 cells without affecting COX-2 expression, showing the relative potency of gamma-tocotrienol approximately delta-tocopherol &gt; gamma-tocopherol &gt;&gt; alpha- or beta-tocopherol.	alpha- or beta-tocopherol	274-299	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-62
19074288-5	2008	Consistently, conditioned media enriched with long-chain carboxychromanols, but not their sulfated counterparts or vitamin E, reduce COX-2 activity in COX-preinduced cells with 5 microM arachidonic acid as substrate.	carboxychromanols	57-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	133-138
19074288-5	2008	Consistently, conditioned media enriched with long-chain carboxychromanols, but not their sulfated counterparts or vitamin E, reduce COX-2 activity in COX-preinduced cells with 5 microM arachidonic acid as substrate.	Arachidonic Acid	186-202	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	133-138
19074288-6	2008	Under this condition, 9"- or 13"-carboxychromanol, the vitamin E metabolites that contain a chromanol linked with a 9- or 13-carbon-length carboxylated side chain, inhibits COX-2 with an IC(50) of 6 or 4 microM, respectively.	9"- or 13"-carboxychromanol	22-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	173-178
19074288-6	2008	Under this condition, 9"- or 13"-carboxychromanol, the vitamin E metabolites that contain a chromanol linked with a 9- or 13-carbon-length carboxylated side chain, inhibits COX-2 with an IC(50) of 6 or 4 microM, respectively.	Vitamin E	55-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	173-178
19074288-6	2008	Under this condition, 9"- or 13"-carboxychromanol, the vitamin E metabolites that contain a chromanol linked with a 9- or 13-carbon-length carboxylated side chain, inhibits COX-2 with an IC(50) of 6 or 4 microM, respectively.	2,2,5,7,8-pentamethyl-1-hydroxychroman	40-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	173-178
19074288-6	2008	Under this condition, 9"- or 13"-carboxychromanol, the vitamin E metabolites that contain a chromanol linked with a 9- or 13-carbon-length carboxylated side chain, inhibits COX-2 with an IC(50) of 6 or 4 microM, respectively.	Carbon	125-131	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	173-178
19074288-7	2008	But 13"-carboxychromanol inhibits purified COX-1 and COX-2 much more potently than shorter side-chain analogs or vitamin E forms by competitively inhibiting their cyclooxygenase activity with K(i) of 3.9 and 10.7 microM, respectively, without affecting the peroxidase activity.	13"-carboxychromanol	4-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-58
19075233-6	2008	GHRH stimulated and GHRH antagonist inhibited the expression of the major antioxidant enzymes, as well as the expression of COX 2 and cytochrome c oxidase IV, which are enzymes involved in the generation of ROS.	Reactive Oxygen Species	207-210	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	124-129
19101538-9	2009	This study provides evidence that inhibition of both COX-1 and COX-2 and the resulting dramatic decrease in the intestinal level of PGE(2) is responsible for NSAID-dependent exacerbation of DSS-induced colitis.	Dextran Sulfate	190-193	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-68
18771702-4	2008	G-Gly induced proliferation, COX-2 mRNA abundance, and PGE2 secretion, were all abolished by inhibition of JAK2, PI3-kinase, Akt or NF-kappaB.	g-gly	0-5	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34
18771702-7	2008	G-Gly increased COX-2 promoter transcription in an Akt and NF-kappaB-dependent manner and also reduced COX-2 mRNA degradation in an Akt-insensitive manner.	g-gly	0-5	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-21
18771702-7	2008	G-Gly increased COX-2 promoter transcription in an Akt and NF-kappaB-dependent manner and also reduced COX-2 mRNA degradation in an Akt-insensitive manner.	g-gly	0-5	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-108
18771702-8	2008	We conclude that G-Gly induced signalling involves a JAK2/PI3-kinase/Akt/NF-kappaB sequence leading to COX-2 transcription.	g-gly	17-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-108
18771702-9	2008	G-Gly also seems to stabilise COX-2 mRNA via a separate pathway.	g-gly	0-5	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-35
18938131-2	2008	This AhR signaling depends on the initial action of TCDD to rapidly increase the intracellular concentration of free Ca(2+), which subsequently activates cPLA2 and additional inflammatory markers (e.g. COX-2 mRNA expression) lasting up to 72h.	Polychlorinated Dibenzodioxins	52-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	202-207
18817855-1	2008	We found that prostaglandin (PG) D(2) production was induced through transcriptional activation of cyclooxygenase (COX)-2 and lipocalin-type PGD synthase (L-PGDS) genes under serum-starved conditions in human brain-derived TE671 cells.	Prostaglandin D2	14-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-121
18817855-6	2008	Moreover, NS-398, a COX-2 inhibitor and AT-56, an L-PGDS inhibitor, suppressed PGD(2) production in TE671 cells cultured under the serum-starved condition.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	10-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-25
18817855-7	2008	These results indicate that PGD(2) production stimulated by serum starvation is mediated by both COX-2 and L-PGDS through enhancement of USF1 in TE671 cells.	Prostaglandin D2	28-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
18998670-0	2008	Straightforward route to the adamantane clusters [Sn4Q10]4- (Q = S, Se, Te) and use in the assembly of open-framework chalcogenides (Me4N)2M[Sn4Se10] (M = Mn(II), Fe(II), Co(II), Zn(II)) including the first telluride member (Me4N)2Mn[Ge4Te10].	Adamantane	29-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	171-177
18998670-0	2008	Straightforward route to the adamantane clusters [Sn4Q10]4- (Q = S, Se, Te) and use in the assembly of open-framework chalcogenides (Me4N)2M[Sn4Se10] (M = Mn(II), Fe(II), Co(II), Zn(II)) including the first telluride member (Me4N)2Mn[Ge4Te10].	chalcogenides	118-131	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	171-177
19006386-0	2008	One- and two-electron reduced 1,2-diketone ligands in [Zn(II)(L*)2(Et2O)], [Co(II)(L*)2(Et2O)], and Na2(Et2O)4[Co(II)(LRed)2].	1,2-diketone	30-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-82
19006386-0	2008	One- and two-electron reduced 1,2-diketone ligands in [Zn(II)(L*)2(Et2O)], [Co(II)(L*)2(Et2O)], and Na2(Et2O)4[Co(II)(LRed)2].	1,2-diketone	30-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	111-117
19006386-2	2008	When 4 equiv of sodium were added, complex Na(2)(Et(2)O)(4)[Co(II)(L(Red))(2)] (4) was isolated, which included some crystals of a minor (&lt;2%) product Na(Et(2)O)(2)[Co(III)(L(Red))(2)] (3).	Sodium	16-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-66
19006386-2	2008	When 4 equiv of sodium were added, complex Na(2)(Et(2)O)(4)[Co(II)(L(Red))(2)] (4) was isolated, which included some crystals of a minor (&lt;2%) product Na(Et(2)O)(2)[Co(III)(L(Red))(2)] (3).	sodium sulfide	43-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-66
19006386-2	2008	When 4 equiv of sodium were added, complex Na(2)(Et(2)O)(4)[Co(II)(L(Red))(2)] (4) was isolated, which included some crystals of a minor (&lt;2%) product Na(Et(2)O)(2)[Co(III)(L(Red))(2)] (3).	et(2)o)	49-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-66
19006386-2	2008	When 4 equiv of sodium were added, complex Na(2)(Et(2)O)(4)[Co(II)(L(Red))(2)] (4) was isolated, which included some crystals of a minor (&lt;2%) product Na(Et(2)O)(2)[Co(III)(L(Red))(2)] (3).	et(2)o	49-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-66
18482860-4	2008	The Co(II) cations present a slightly distorted CoN2O4 octahedral environment, with equatorially coordinated water molecules and axially pyridine N-bound ethylisonicotinate ligands.	Water	109-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
18482860-4	2008	The Co(II) cations present a slightly distorted CoN2O4 octahedral environment, with equatorially coordinated water molecules and axially pyridine N-bound ethylisonicotinate ligands.	pyridine n	137-147	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
18482860-4	2008	The Co(II) cations present a slightly distorted CoN2O4 octahedral environment, with equatorially coordinated water molecules and axially pyridine N-bound ethylisonicotinate ligands.	ethyl isonicotinate	154-172	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
18482860-5	2008	The magnetic environments of Cu2+-doped Co(II) complex have been identified by electron paramagnetic resonance (EPR) technique.	cupric ion	29-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-46
18534903-0	2008	Synthesis of some novel CoII and CoIII complexes by tribochemical reactions using KI with some derivatives of thiosemicarbazide complexes derived from Girard"s T and P. The starting Co(II) complexes of the general formulae, [Co(L1)2]Cl4.4H2O, [Co(L1)Cl2]Cl (L1=N-([(allyl amino)thioxomethyl]hydrazinocarbonylmethyl) trimethylammonium chloride; ATHTC), [Co(L2)Cl]Cl.2H2O.	thiosemicarbazide	110-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	182-188
18534903-7	2008	The isolated solid CoII and CoIII complexes have been characterized by elemental analyses, conductivities, spectral (IR, UV-vis, 1H NMR) and magnetic measurements.	Hydrogen	129-131	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-23
18534903-8	2008	The IR spectra of the starting CoII complexes indicate that both L1 and L3 behave in bidentate manner coordinating via the carbonyl oxygen and NH2 groups, but L2 behaves as a tridentate fashion coordinating via the carbonyl oxygen, azomethine (C=N2) and SH groups with displacement of a hydrogen atom from the latter group.	Oxygen	132-138	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-35
18534903-8	2008	The IR spectra of the starting CoII complexes indicate that both L1 and L3 behave in bidentate manner coordinating via the carbonyl oxygen and NH2 groups, but L2 behaves as a tridentate fashion coordinating via the carbonyl oxygen, azomethine (C=N2) and SH groups with displacement of a hydrogen atom from the latter group.	Oxygen	224-230	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-35
18534903-8	2008	The IR spectra of the starting CoII complexes indicate that both L1 and L3 behave in bidentate manner coordinating via the carbonyl oxygen and NH2 groups, but L2 behaves as a tridentate fashion coordinating via the carbonyl oxygen, azomethine (C=N2) and SH groups with displacement of a hydrogen atom from the latter group.	azomethine	232-242	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-35
18534903-8	2008	The IR spectra of the starting CoII complexes indicate that both L1 and L3 behave in bidentate manner coordinating via the carbonyl oxygen and NH2 groups, but L2 behaves as a tridentate fashion coordinating via the carbonyl oxygen, azomethine (C=N2) and SH groups with displacement of a hydrogen atom from the latter group.	Hydrogen	287-295	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-35
18534903-9	2008	On the other hand, the IR spectra of the iodide CoII and CoIII complexes, synthesized by tribochemical reactions, suggest that L1" behaves only in a bidentate fashion via NH1 and CS groups.	Iodides	41-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-52
18534903-13	2008	The diamagnetic nature for three of the five iodide complexes, prepared by tribochemical reactions, suggests the oxidation of CoII to CoIII ion and the existence of low spin-octahedral geometry around the CoIII ion.	Iodides	45-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-130
18534903-14	2008	Finally, the results of the rest of the iodide CoII complexes suggest either tetrahedral and/or high-spin octahedral geometry.	Iodides	40-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-51
18948121-6	2008	Furthermore, the BK-induced increase in COX-2 expression was blocked by the PI-3 kinase inhibitors wortmannin and LY294002, Akt inhibitor, and the protein kinase C (PKC) inhibitors staurosporine and bisindolylmaleimide I, suggesting the role of PI-3 kinase and PKC in this process.	Wortmannin	99-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
18948121-6	2008	Furthermore, the BK-induced increase in COX-2 expression was blocked by the PI-3 kinase inhibitors wortmannin and LY294002, Akt inhibitor, and the protein kinase C (PKC) inhibitors staurosporine and bisindolylmaleimide I, suggesting the role of PI-3 kinase and PKC in this process.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	114-122	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
18948121-6	2008	Furthermore, the BK-induced increase in COX-2 expression was blocked by the PI-3 kinase inhibitors wortmannin and LY294002, Akt inhibitor, and the protein kinase C (PKC) inhibitors staurosporine and bisindolylmaleimide I, suggesting the role of PI-3 kinase and PKC in this process.	Staurosporine	181-194	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
18948121-6	2008	Furthermore, the BK-induced increase in COX-2 expression was blocked by the PI-3 kinase inhibitors wortmannin and LY294002, Akt inhibitor, and the protein kinase C (PKC) inhibitors staurosporine and bisindolylmaleimide I, suggesting the role of PI-3 kinase and PKC in this process.	bisindolylmaleimide I	199-220	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
18948121-8	2008	SIGNIFICANCE: BK stimulates glutamate uptake through a PKC-Akt-COX-2 signaling cascade in ARPE cells.	Glutamic Acid	28-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-68
19006282-0	2008	Coordination properties of lysine interacting with Co(I) and Co(II).	Lysine	27-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-67
19057066-1	2008	The title compound, [Co(C(18)H(23)N(10))](BF(4))(2) x H(2)O, is the result of complexing a Co cation (initially in a Co(II) state) with tris[2-(1H-imidazol-2-ylmethyleneamino)ethyl]amine (L), obtained by a condensation process involving imidazole-2-carbaldehyde and tris(2-aminoethyl)amine.	co(c(18)h	21-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-123
19057066-1	2008	The title compound, [Co(C(18)H(23)N(10))](BF(4))(2) x H(2)O, is the result of complexing a Co cation (initially in a Co(II) state) with tris[2-(1H-imidazol-2-ylmethyleneamino)ethyl]amine (L), obtained by a condensation process involving imidazole-2-carbaldehyde and tris(2-aminoethyl)amine.	fluoroboric acid	42-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-123
19057066-1	2008	The title compound, [Co(C(18)H(23)N(10))](BF(4))(2) x H(2)O, is the result of complexing a Co cation (initially in a Co(II) state) with tris[2-(1H-imidazol-2-ylmethyleneamino)ethyl]amine (L), obtained by a condensation process involving imidazole-2-carbaldehyde and tris(2-aminoethyl)amine.	Water	54-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-123
19057066-1	2008	The title compound, [Co(C(18)H(23)N(10))](BF(4))(2) x H(2)O, is the result of complexing a Co cation (initially in a Co(II) state) with tris[2-(1H-imidazol-2-ylmethyleneamino)ethyl]amine (L), obtained by a condensation process involving imidazole-2-carbaldehyde and tris(2-aminoethyl)amine.	tris[2-(1h-imidazol-2-ylmethyleneamino)ethyl]amine	136-186	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-123
18842828-5	2008	MGO induced mRNA and protein expression of cyclooxygenase (COX)-2 in a concentration (0-420 microM)- and time (6-24 h)-dependent manner.	Pyruvaldehyde	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-65
18842828-6	2008	COX-2 induction was associated with increased PGE(2) release.	Prostaglandins E	46-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
18842828-8	2008	Both the JNK inhibitor SP600125 and the p38 inhibitor SB203580 prevented the MGO induction of COX-2.	pyrazolanthrone	23-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-99
18842828-8	2008	Both the JNK inhibitor SP600125 and the p38 inhibitor SB203580 prevented the MGO induction of COX-2.	SB 203580	54-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-99
18842828-8	2008	Both the JNK inhibitor SP600125 and the p38 inhibitor SB203580 prevented the MGO induction of COX-2.	Pyruvaldehyde	77-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-99
18606398-6	2008	In this study we provide experimental evidence that resveratrol inhibits the expression of VEGF, MMP-3, MMP-9 and COX-2 in human articular chondrocytes stimulated with the pro-inflammatory cytokine IL-1beta.	Resveratrol	52-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-119
18945614-1	2008	A hitherto unknown class of celecoxib analogs was designed for evaluation as dual inhibitors of the 5-lipoxygenase/cyclooxygenase-2 (5-LOX/COX-2) enzymes.	Celecoxib	28-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-144
19075637-8	2008	This provided the rationale to target cox-2 enzyme and development of cox-2 selective drugs such as Vioxx and Celebrex.	rofecoxib	100-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-43
19075637-8	2008	This provided the rationale to target cox-2 enzyme and development of cox-2 selective drugs such as Vioxx and Celebrex.	rofecoxib	100-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-75
19075637-8	2008	This provided the rationale to target cox-2 enzyme and development of cox-2 selective drugs such as Vioxx and Celebrex.	Celecoxib	110-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-43
19075637-8	2008	This provided the rationale to target cox-2 enzyme and development of cox-2 selective drugs such as Vioxx and Celebrex.	Celecoxib	110-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-75
18717821-7	2008	CT transcriptionally downregulates the AMPs by activating several intracellular signalling pathways involving protein kinase A (PKA), ERK MAPKinase and Cox-2 downstream of cAMP accumulation and inducible cAMP early repressor (ICER) may mediate this role of CT, at least in part.	Adenylyl sulfate	39-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-157
18717821-7	2008	CT transcriptionally downregulates the AMPs by activating several intracellular signalling pathways involving protein kinase A (PKA), ERK MAPKinase and Cox-2 downstream of cAMP accumulation and inducible cAMP early repressor (ICER) may mediate this role of CT, at least in part.	Cyclic AMP	172-176	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-157
18717821-7	2008	CT transcriptionally downregulates the AMPs by activating several intracellular signalling pathways involving protein kinase A (PKA), ERK MAPKinase and Cox-2 downstream of cAMP accumulation and inducible cAMP early repressor (ICER) may mediate this role of CT, at least in part.	Cyclic AMP	204-208	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-157
18997524-4	2008	Perioperative use of the COX-2 selective inhibitor celecoxib seems to provide short-term and long-term postoperative advantages.	Celecoxib	51-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-30
18262309-0	2008	2,3,5-Substituted tetrahydrofurans: COX-2 inhibitory activities of 5-hydroxymethyl-/carboxyl-2,3-diaryl-tetrahydro-furan-3-ols.	2,3,5-substituted tetrahydrofurans	0-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-41
18262309-0	2008	2,3,5-Substituted tetrahydrofurans: COX-2 inhibitory activities of 5-hydroxymethyl-/carboxyl-2,3-diaryl-tetrahydro-furan-3-ols.	5-hydroxymethyl-/carboxyl-2,3-diaryl-tetrahydro-furan-3-ols	67-126	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-41
18262309-1	2008	5-Hydroxymethyl-/carboxyl-2,3-diaryl-tetrahydro-furan-3-ols have been investigated for their COX-1 and COX-2 inhibitory activities.	5-hydroxymethyl-/carboxyl-2,3-diaryl-tetrahydro-furan-3-ols	0-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-108
19174085-4	2008	Notable among these mechanisms are Kupffer cell activation and inflammatory cell recruitment, free oxygen radical formation and the development of oxidative stress, cytokine production, mainly TNFa and TGFb, and inflammatory mediator release due to arachidonic acid oxidation through the COX-2 and 5-LO pathways.	Arachidonic Acid	249-265	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	288-299
18716040-1	2008	BACKGROUND: Celecoxib, a selective cyclooxygenase (COX)-2 inhibitor, also has anti-proliferative properties and pro-apoptotic effects on different in vivo and in vitro models, two actions that may be efficacious in therapy for endometriosis.	Celecoxib	12-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-57
18716040-7	2008	Western blot analysis showed that celecoxib was effective at increasing COX-2 protein at 100 microM in EEC from endometriosis patients (P &lt; 0.05).	Celecoxib	34-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
18716040-8	2008	In EEC from endometriosis patients, celecoxib at 25, 50 and 100 microM was also effective in reducing COX-2 activity, reflected in the reduction of prostaglandin E(2) (PGE(2)) synthesis (P &lt; 0.001), and VEGF secretion (P &lt; 0.001; P &lt; 0.05 and P &lt; 0.001), assessed by enzyme-linked immunosorbent assay.	Celecoxib	36-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-107
23100954-5	2008	We found a short course of Cox-2 (etoricoxib) inhibitor to be an extremely useful adjunct.	Etoricoxib	34-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-32
18975935-3	2008	Ni[(C(6)H(5)PO(3))(H(2)O)] crystallizes in the orthorhombic space group Pmn2(1) and is isostructural with the Mn(II), Fe(II), and Co(II) analogues.	(c(6)h(5)po(3))	3-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	130-136
18975935-3	2008	Ni[(C(6)H(5)PO(3))(H(2)O)] crystallizes in the orthorhombic space group Pmn2(1) and is isostructural with the Mn(II), Fe(II), and Co(II) analogues.	Water	19-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	130-136
18808197-3	2008	The complexes of Fe(II) and Co(II) with phthalocyanines are extremely good catalysts of oxidation of organic compounds with molecular oxygen and hydrogen peroxide.	phthalocyanine	40-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-34
18808197-3	2008	The complexes of Fe(II) and Co(II) with phthalocyanines are extremely good catalysts of oxidation of organic compounds with molecular oxygen and hydrogen peroxide.	Oxygen	134-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-34
18808197-3	2008	The complexes of Fe(II) and Co(II) with phthalocyanines are extremely good catalysts of oxidation of organic compounds with molecular oxygen and hydrogen peroxide.	Hydrogen Peroxide	145-162	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-34
18808197-8	2008	The resulting oppositely charged phthalocyanine complexes showed significant increase of catalytic activity compared with monomeric forms of phthalocyanines Fe(II) and Co(II).	phthalocyanine	33-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	168-174
18808197-10	2008	It was determined that oxidation of DNA by molecular oxygen catalyzed by complex of Fe(II)-phthalocyanines proceeds with higher rate than in the case of Co(II)-phthalocyanines but the latter led to a greater extent of target DNA modification.	Oxygen	53-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	153-159
18808197-10	2008	It was determined that oxidation of DNA by molecular oxygen catalyzed by complex of Fe(II)-phthalocyanines proceeds with higher rate than in the case of Co(II)-phthalocyanines but the latter led to a greater extent of target DNA modification.	fe(ii)-phthalocyanines	84-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	153-159
19033666-3	2008	Upregulation of one such protein, COX-2, generates PGs that induce contractions.	Phosphatidylglycerols	51-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-39
18618364-1	2008	The present paper describes the synthesis, characterization and in vitro biological evaluation screening of different classes (ammoniacates, dioximates, carboxylates, semi- and thiosemicarbazidates) of Co(II), Co(III), Cu(II), Ni(II), Mn(II), Zn(II) and Fe(III) complexes.	ammoniacates	127-139	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	202-208
18618364-1	2008	The present paper describes the synthesis, characterization and in vitro biological evaluation screening of different classes (ammoniacates, dioximates, carboxylates, semi- and thiosemicarbazidates) of Co(II), Co(III), Cu(II), Ni(II), Mn(II), Zn(II) and Fe(III) complexes.	dioximates	141-151	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	202-208
18618364-1	2008	The present paper describes the synthesis, characterization and in vitro biological evaluation screening of different classes (ammoniacates, dioximates, carboxylates, semi- and thiosemicarbazidates) of Co(II), Co(III), Cu(II), Ni(II), Mn(II), Zn(II) and Fe(III) complexes.	Manganese(2+)	235-241	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	202-208
18618364-1	2008	The present paper describes the synthesis, characterization and in vitro biological evaluation screening of different classes (ammoniacates, dioximates, carboxylates, semi- and thiosemicarbazidates) of Co(II), Co(III), Cu(II), Ni(II), Mn(II), Zn(II) and Fe(III) complexes.	carboxylates	153-165	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	202-208
18618364-1	2008	The present paper describes the synthesis, characterization and in vitro biological evaluation screening of different classes (ammoniacates, dioximates, carboxylates, semi- and thiosemicarbazidates) of Co(II), Co(III), Cu(II), Ni(II), Mn(II), Zn(II) and Fe(III) complexes.	Zinc	243-249	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	202-208
18618364-1	2008	The present paper describes the synthesis, characterization and in vitro biological evaluation screening of different classes (ammoniacates, dioximates, carboxylates, semi- and thiosemicarbazidates) of Co(II), Co(III), Cu(II), Ni(II), Mn(II), Zn(II) and Fe(III) complexes.	ferric sulfate	254-261	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	202-208
18618364-1	2008	The present paper describes the synthesis, characterization and in vitro biological evaluation screening of different classes (ammoniacates, dioximates, carboxylates, semi- and thiosemicarbazidates) of Co(II), Co(III), Cu(II), Ni(II), Mn(II), Zn(II) and Fe(III) complexes.	thiosemicarbazidates	177-197	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	202-208
18618364-1	2008	The present paper describes the synthesis, characterization and in vitro biological evaluation screening of different classes (ammoniacates, dioximates, carboxylates, semi- and thiosemicarbazidates) of Co(II), Co(III), Cu(II), Ni(II), Mn(II), Zn(II) and Fe(III) complexes.	Nickel(2+)	227-233	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	202-208
18975264-7	2008	COX-2:cyclooxygenase 2 EMSA:electrophoretic mobility shift assay fMLP: N-formyl-methionyl-leucyl-phenylalanine HaCaT:human keratinocyte HNE:human neutrophil elastase IkappaB:inhibitory subunit of kappaB iNOS:inducible nitric oxide synthase NF-kappaB:nuclear factor kappaB PAF:platelet activating factor STL:sesquiterpene lactone TNF-alpha:tumor necrosis factor alpha.	nitric	218-224	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
18992738-1	2008	We have previously reported that black tea polyphenol theaflavin monogallate (TF-2) suppressed COX-2 and induced apoptosis in human colon cancer cells [Lu, J.B., Ho, C.-T., Ghai, G., Chen, K.Y., 2000.	polyphenol theaflavin monogallate	43-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-100
18992738-2	2008	Differential effects of theaflavin monogallates on cell growth, apoptosis and Cox-2 gene expression in cancerous versus normal cells.	theaflavin	24-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-83
18975264-7	2008	COX-2:cyclooxygenase 2 EMSA:electrophoretic mobility shift assay fMLP: N-formyl-methionyl-leucyl-phenylalanine HaCaT:human keratinocyte HNE:human neutrophil elastase IkappaB:inhibitory subunit of kappaB iNOS:inducible nitric oxide synthase NF-kappaB:nuclear factor kappaB PAF:platelet activating factor STL:sesquiterpene lactone TNF-alpha:tumor necrosis factor alpha.	sesquiterpene lactone	307-328	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
18343191-0	2008	EPR study of Cu(2+)-doped tetraaqua-di(nicotinamide)Co(II) saccharinate single crystals.	cu(2+)-doped	13-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-57
19141979-1	2008	OBJECTIVE: To determine the effect of a selective COX-2 inhibitor celecoxib on cell proliferation and apoptosis of gastric cancer cell line BGC-823 to seek an effective and safe drug for gastric cancer chemoprevention.	Celecoxib	66-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-55
18809379-0	2008	NS-398, a selective COX-2 inhibitor, inhibits proliferation of IL-1beta-stimulated vascular smooth muscle cells by induction of HO-1.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	0-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-25
18809379-1	2008	We investigated whether NS-398, a selective inhibitor of COX-2, induces HO-1 in IL-1beta-stimulated vascular smooth muscle cells (VSMC).	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	24-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-62
18809379-4	2008	Furthermore, SnPPIX, a HO-1 inhibitor, reversed the effects of NS-398 on PGE(2) production, suggesting that COX-2 activity can be affected by HO-1.	tin protoporphyrin IX	13-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-113
18809379-4	2008	Furthermore, SnPPIX, a HO-1 inhibitor, reversed the effects of NS-398 on PGE(2) production, suggesting that COX-2 activity can be affected by HO-1.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	63-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-113
18809379-4	2008	Furthermore, SnPPIX, a HO-1 inhibitor, reversed the effects of NS-398 on PGE(2) production, suggesting that COX-2 activity can be affected by HO-1.	Dinoprostone	73-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-113
21581217-1	2008	In the title compound, [Co(C(8)H(8)NO(3))(2)], the Co(II) atom lies on a centre of inversion and is coordinated in a slightly distorted square-planar geometry by two N and two O atoms from the 2-hydroxy-imino-methyl-6-methoxy-phenolate ligands.	co(c(8)h(8)no(3))	24-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-57
21581217-1	2008	In the title compound, [Co(C(8)H(8)NO(3))(2)], the Co(II) atom lies on a centre of inversion and is coordinated in a slightly distorted square-planar geometry by two N and two O atoms from the 2-hydroxy-imino-methyl-6-methoxy-phenolate ligands.	Nitrogen	35-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-57
21581217-1	2008	In the title compound, [Co(C(8)H(8)NO(3))(2)], the Co(II) atom lies on a centre of inversion and is coordinated in a slightly distorted square-planar geometry by two N and two O atoms from the 2-hydroxy-imino-methyl-6-methoxy-phenolate ligands.	2-hydroxy-imino-methyl-6-methoxy-phenolate	193-235	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-57
18985241-2	2008	Crystal structural analysis revealed that two Co(III) ions were linked to a central triangular Co(II) core through HL(3-) and H2L(2-) hydroxyl groups.	co(iii)	46-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-101
21581181-1	2008	The Co(II) ion in the title complex, [Co(2)(C(4)H(5)O(2))(4)(C(15)H(13)N(5))(2)] 2H(2)O, has a distorted square-planar coordination formed by the bridging bidentate N,N"-di-4-pyridylpyrid-ine-2,6-diamine (dapmp) ligands and two monodentate carboxyl-ate groups from methacrylates.	co(2)(	38-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
21581181-1	2008	The Co(II) ion in the title complex, [Co(2)(C(4)H(5)O(2))(4)(C(15)H(13)N(5))(2)] 2H(2)O, has a distorted square-planar coordination formed by the bridging bidentate N,N"-di-4-pyridylpyrid-ine-2,6-diamine (dapmp) ligands and two monodentate carboxyl-ate groups from methacrylates.	c(4)h(5)o(2))(4)	44-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
21581181-1	2008	The Co(II) ion in the title complex, [Co(2)(C(4)H(5)O(2))(4)(C(15)H(13)N(5))(2)] 2H(2)O, has a distorted square-planar coordination formed by the bridging bidentate N,N"-di-4-pyridylpyrid-ine-2,6-diamine (dapmp) ligands and two monodentate carboxyl-ate groups from methacrylates.	h(13)n(5))(2)] 2h(2)o	66-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
21581181-1	2008	The Co(II) ion in the title complex, [Co(2)(C(4)H(5)O(2))(4)(C(15)H(13)N(5))(2)] 2H(2)O, has a distorted square-planar coordination formed by the bridging bidentate N,N"-di-4-pyridylpyrid-ine-2,6-diamine (dapmp) ligands and two monodentate carboxyl-ate groups from methacrylates.	bidentate n,n"-di-4-pyridylpyrid-ine-2,6-diamine	155-203	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
21581181-1	2008	The Co(II) ion in the title complex, [Co(2)(C(4)H(5)O(2))(4)(C(15)H(13)N(5))(2)] 2H(2)O, has a distorted square-planar coordination formed by the bridging bidentate N,N"-di-4-pyridylpyrid-ine-2,6-diamine (dapmp) ligands and two monodentate carboxyl-ate groups from methacrylates.	dapmp	205-210	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
21581181-1	2008	The Co(II) ion in the title complex, [Co(2)(C(4)H(5)O(2))(4)(C(15)H(13)N(5))(2)] 2H(2)O, has a distorted square-planar coordination formed by the bridging bidentate N,N"-di-4-pyridylpyrid-ine-2,6-diamine (dapmp) ligands and two monodentate carboxyl-ate groups from methacrylates.	carboxyl-ate	240-252	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
21581181-1	2008	The Co(II) ion in the title complex, [Co(2)(C(4)H(5)O(2))(4)(C(15)H(13)N(5))(2)] 2H(2)O, has a distorted square-planar coordination formed by the bridging bidentate N,N"-di-4-pyridylpyrid-ine-2,6-diamine (dapmp) ligands and two monodentate carboxyl-ate groups from methacrylates.	Methacrylates	265-278	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
18847187-1	2008	Self-assembly of a tetradentate ligand, N, N"-bi(salicylidene)-2,6-pyridinediamine (H 2L), with Cu(II) or Co(II), affords a dinuclear [Cu 2L 2] complex ( 1) or a trinuclear [Co 3L 3] complex ( 2), which were characterized by the single crystal X-ray diffraction study.	n, n"-bi(salicylidene)-2,6-pyridinediamine	40-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-112
18847187-1	2008	Self-assembly of a tetradentate ligand, N, N"-bi(salicylidene)-2,6-pyridinediamine (H 2L), with Cu(II) or Co(II), affords a dinuclear [Cu 2L 2] complex ( 1) or a trinuclear [Co 3L 3] complex ( 2), which were characterized by the single crystal X-ray diffraction study.	h 2l	84-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-112
18847187-1	2008	Self-assembly of a tetradentate ligand, N, N"-bi(salicylidene)-2,6-pyridinediamine (H 2L), with Cu(II) or Co(II), affords a dinuclear [Cu 2L 2] complex ( 1) or a trinuclear [Co 3L 3] complex ( 2), which were characterized by the single crystal X-ray diffraction study.	cu 2l 2	135-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-112
18847187-1	2008	Self-assembly of a tetradentate ligand, N, N"-bi(salicylidene)-2,6-pyridinediamine (H 2L), with Cu(II) or Co(II), affords a dinuclear [Cu 2L 2] complex ( 1) or a trinuclear [Co 3L 3] complex ( 2), which were characterized by the single crystal X-ray diffraction study.	co 3l 3	174-181	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-112
18930406-7	2008	These studies indicate hybrid ester AI/NO-donor prodrugs (NONO-coxibs) constitutes a plausible drug design concept targeted toward the development of selective COX-2 inhibitory AI drugs that are devoid of adverse cardiovascular effects.	Esters	30-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	160-165
18308622-1	2008	Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) complexes of salicylidene-N-cyano-acetohydrazone H2L1 and 2-hydroxy-l-naphthylidene-N-cyanoacetohydrazone H2L2 have been prepared in ethanolic solution and characterized by analytical, spectral, magnetic susceptibility, molar conductivity and TGA measurements.	Zinc	35-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	8-14
18308622-1	2008	Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) complexes of salicylidene-N-cyano-acetohydrazone H2L1 and 2-hydroxy-l-naphthylidene-N-cyanoacetohydrazone H2L2 have been prepared in ethanolic solution and characterized by analytical, spectral, magnetic susceptibility, molar conductivity and TGA measurements.	salicylidene-n-cyano-acetohydrazone h2l1	55-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	8-14
18308622-1	2008	Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) complexes of salicylidene-N-cyano-acetohydrazone H2L1 and 2-hydroxy-l-naphthylidene-N-cyanoacetohydrazone H2L2 have been prepared in ethanolic solution and characterized by analytical, spectral, magnetic susceptibility, molar conductivity and TGA measurements.	2-hydroxy-l-naphthylidene-n-cyanoacetohydrazone h2l2	100-152	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	8-14
18308622-5	2008	The ligand field parameters were calculated for the Co(II) and Ni(II) complexes and the data show that the covalent character of the metal ligand sigma-bond is low.	Metals	133-138	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-58
21581161-1	2008	In the title complex, [Co(C(5)H(5)NO(4)P)(2)(H(2)O)(2)], the Co(II) ion, which lies on a crystallographic inversion center, is coordin-ated by four O atoms from two bidentate 2-phospho-nato-pyridine N-oxide ligands and two O atoms from two water ligands in a slightly distorted octa-hedral environment.	co(c(5)h(5)no(4)p)	23-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-67
21581161-1	2008	In the title complex, [Co(C(5)H(5)NO(4)P)(2)(H(2)O)(2)], the Co(II) ion, which lies on a crystallographic inversion center, is coordin-ated by four O atoms from two bidentate 2-phospho-nato-pyridine N-oxide ligands and two O atoms from two water ligands in a slightly distorted octa-hedral environment.	Water	45-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-67
21581161-1	2008	In the title complex, [Co(C(5)H(5)NO(4)P)(2)(H(2)O)(2)], the Co(II) ion, which lies on a crystallographic inversion center, is coordin-ated by four O atoms from two bidentate 2-phospho-nato-pyridine N-oxide ligands and two O atoms from two water ligands in a slightly distorted octa-hedral environment.	2-phospho-nato-pyridine n-oxide	175-206	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-67
21581161-1	2008	In the title complex, [Co(C(5)H(5)NO(4)P)(2)(H(2)O)(2)], the Co(II) ion, which lies on a crystallographic inversion center, is coordin-ated by four O atoms from two bidentate 2-phospho-nato-pyridine N-oxide ligands and two O atoms from two water ligands in a slightly distorted octa-hedral environment.	Water	240-245	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-67
18841975-3	2008	Consistent with these findings, sinapic acid inhibited LPS-induced expressions of inducible nitric oxide synthase (iNOS) and cyclooxygase (COX)-2 at the protein levels, and iNOS, COX-2, TNF-alpha, and IL-1beta mRNA expression in RAW 264.7 macrophages, as determined by Western blotting and reverse-transcribed polymerase chain reaction, respectively.	sinapinic acid	32-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-145
18841975-3	2008	Consistent with these findings, sinapic acid inhibited LPS-induced expressions of inducible nitric oxide synthase (iNOS) and cyclooxygase (COX)-2 at the protein levels, and iNOS, COX-2, TNF-alpha, and IL-1beta mRNA expression in RAW 264.7 macrophages, as determined by Western blotting and reverse-transcribed polymerase chain reaction, respectively.	sinapinic acid	32-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	179-184
18841975-4	2008	Sinapic acid suppressed the LPS-induced activation of nuclear factor-kappaB (NF-kappaB), a transcription factor pivotal necessary for pro-inflammatory mediators, such as iNOS, COX-2, TNF-alpha, and IL-1beta.	sinapinic acid	0-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	176-181
18841975-9	2008	These results suggest that the suppressions of the expressions of iNOS, COX-2, TNF-alpha, and IL-1beta via NF-kappaB inactivation are responsible for the anti-inflammatory effects of sinapic acid.	sinapinic acid	183-195	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
18854902-2	2008	These studies indicated that only Co(II) complexed with glycylglycylhistidine (GGH) induced DNA strand breaks at low sulfite concentrations (1-80 microM) via strong oxidants formed in the reaction.	diglycyl-histidine	56-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-40
18854902-2	2008	These studies indicated that only Co(II) complexed with glycylglycylhistidine (GGH) induced DNA strand breaks at low sulfite concentrations (1-80 microM) via strong oxidants formed in the reaction.	diglycyl-histidine	79-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-40
18854902-2	2008	These studies indicated that only Co(II) complexed with glycylglycylhistidine (GGH) induced DNA strand breaks at low sulfite concentrations (1-80 microM) via strong oxidants formed in the reaction.	Sulfites	117-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-40
18854902-3	2008	In the presence of the other complexes, some damage occurred only in the presence of high sulfite concentrations (0.1-2.0 mM) after incubation for 4 h. In the presence of GGH, Co(II) and dissolved O2, DNA damage must involve a reactive high-valent cobalt complex.	Sulfites	90-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	176-182
18854902-3	2008	In the presence of the other complexes, some damage occurred only in the presence of high sulfite concentrations (0.1-2.0 mM) after incubation for 4 h. In the presence of GGH, Co(II) and dissolved O2, DNA damage must involve a reactive high-valent cobalt complex.	Cobalt	248-254	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	176-182
18854902-6	2008	The results indicate that Co(II) binds O2 in the presence of GGH, and leads to the formation of a DMPO-HO adduct without first forming free superoxide or hydroxyl radical, supporting the participation of a reactive high-valent cobalt complex.	Oxygen	39-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-32
18854902-6	2008	The results indicate that Co(II) binds O2 in the presence of GGH, and leads to the formation of a DMPO-HO adduct without first forming free superoxide or hydroxyl radical, supporting the participation of a reactive high-valent cobalt complex.	Superoxides	140-150	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-32
18854902-6	2008	The results indicate that Co(II) binds O2 in the presence of GGH, and leads to the formation of a DMPO-HO adduct without first forming free superoxide or hydroxyl radical, supporting the participation of a reactive high-valent cobalt complex.	Hydroxyl Radical	154-170	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-32
18854902-6	2008	The results indicate that Co(II) binds O2 in the presence of GGH, and leads to the formation of a DMPO-HO adduct without first forming free superoxide or hydroxyl radical, supporting the participation of a reactive high-valent cobalt complex.	Cobalt	227-233	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-32
21581110-1	2008	In the title complex, [Co(C(15)H(14)NO)(2)], the Co(II) atom, situated on an inversion centre, is coordinated by two O and two N atoms from two symmetry-related bidentate Schiff base ligands in a slightly distorted square-planar geometry.	co(c(15)h(14)no)	23-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-55
21581110-1	2008	In the title complex, [Co(C(15)H(14)NO)(2)], the Co(II) atom, situated on an inversion centre, is coordinated by two O and two N atoms from two symmetry-related bidentate Schiff base ligands in a slightly distorted square-planar geometry.	Nitrogen	36-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-55
21581110-1	2008	In the title complex, [Co(C(15)H(14)NO)(2)], the Co(II) atom, situated on an inversion centre, is coordinated by two O and two N atoms from two symmetry-related bidentate Schiff base ligands in a slightly distorted square-planar geometry.	Schiff Bases	171-182	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-55
18760329-5	2008	In addition, phenidone was superior in attenuating LPS-induced dopaminergic neurodegeneration and microglia activation, probably as a result of dual inhibition of COX-2 and LOX.	phenidone	13-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	163-168
18790994-5	2008	The tryptase-stimulated PGE(2) production was inhibited by treating HSAEC with the cyclooxygenase (COX)-1-selective inhibitor SC-560 and the nonselective COX inhibitor aspirin but not by the COX-2-selective inhibitor CAY10404, indicating that the early release of arachidonic acid is metabolized by constitutive COX-1 to form PGE(2) in tryptase-stimulated HSAEC.	Prostaglandins E	24-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	191-196
19189639-4	2008	MATERIALS AND METHODS: Cell proliferation and the expression of PPARgamma, cyclooxygenase (COX)-2 and cyclin D1 were assessed in colon cancer cells treated with CGZ or PGZ.	Pioglitazone	168-171	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-97
19189639-9	2008	CONCLUSION: PGZ down-regulates COX-2 and cyclin D1 and inhibits colon cancer proliferation and liver metastasis, making PPARgamma a candidate target for the treatment/prevention of colon cancer metastasis.	Pioglitazone	12-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-36
18725385-0	2008	Cox-2 inactivates Smad signaling and enhances EMT stimulated by TGF-beta through a PGE2-dependent mechanisms.	Dinoprostone	83-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
18725385-6	2008	Along these lines, elevated Cox-2 expression elicited prostaglandin E(2) (PGE(2)) production and the autocrine activation of EP receptors, which antagonized Smad2/3 signaling in normal and malignant MECs.	Dinoprostone	54-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
18725385-6	2008	Along these lines, elevated Cox-2 expression elicited prostaglandin E(2) (PGE(2)) production and the autocrine activation of EP receptors, which antagonized Smad2/3 signaling in normal and malignant MECs.	Dinoprostone	74-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
18725385-7	2008	Importantly, rendering normal and malignant MECs Cox-2 deficient inhibited their production of PGE(2) and acquisition of an EMT morphology as well as potentiated their nuclear accumulation of Smad2/3 and transcription of plasminogen activator inhibitor-1 and p15 messenger RNA.	Prostaglandins E	95-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-54
18671715-6	2008	The predominant endocannabinoids, anandamide and 2-arachidonoylglycerol, not only mediate their effects via two recognized cannabinoid receptor subtypes, namely CB(1) and CB(2), but emerging evidence now shows they are also substrates for cyclo-oxygenase (COX)-2, generating a distinct and novel class of prostaglandin ethanolamides (prostamides) and prostaglandin glycerol esters.	anandamide	34-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	239-262
18671715-6	2008	The predominant endocannabinoids, anandamide and 2-arachidonoylglycerol, not only mediate their effects via two recognized cannabinoid receptor subtypes, namely CB(1) and CB(2), but emerging evidence now shows they are also substrates for cyclo-oxygenase (COX)-2, generating a distinct and novel class of prostaglandin ethanolamides (prostamides) and prostaglandin glycerol esters.	glyceryl 2-arachidonate	49-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	239-262
18753249-2	2008	Clinical data show that mixed COX-1/COX-2 inhibitors such as aspirin, but not COX-2 selective inhibitors such as rofecoxib, induce bronchoconstriction and asthma in sensitive individuals.	Aspirin	61-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-41
18809239-7	2008	The increase in total COX activity observed in SCD was due to enhanced activity of COX-2, differentiated by using the isoform-specific inhibitors DuP-697 and SC-560.	DuP 697	146-153	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
18809239-7	2008	The increase in total COX activity observed in SCD was due to enhanced activity of COX-2, differentiated by using the isoform-specific inhibitors DuP-697 and SC-560.	SC 560	158-164	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
18753249-8	2008	Cells cultured from aspirin-sensitive or control human donors contained similar levels of COX-1 and COX-2 immunoreactivity.	Aspirin	20-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-105
18844676-1	2008	In this study, quantitative structure-protein binding relationships have been derived to predict the binding affinities of cox-2 inhibitor drugs to HSA from the structure of drug molecules.	Altretamine	148-151	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-128
18767115-9	2008	Further experiments suggested that XOR derived ROS mediated this effect and also modulated COX-2 and MMP levels and function.	ros	47-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-96
18976171-8	2008	Nabumetone was found to significantly increase COX-2 at mRNA levels but directly suppress the concentration of PGE2 in culture medium.	Nabumetone	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
18664589-5	2008	PC, but not SC, was correlated with apical membrane Cl- conductance and was inhibited by the cyclooxygenase (COX)-2 inhibitor NS-398 (N-[2-(cyclohexyloxyl)-4-nitrophenyl]-methane sulfonamide; 10 microM).	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	126-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-115
18664589-5	2008	PC, but not SC, was correlated with apical membrane Cl- conductance and was inhibited by the cyclooxygenase (COX)-2 inhibitor NS-398 (N-[2-(cyclohexyloxyl)-4-nitrophenyl]-methane sulfonamide; 10 microM).	n-[2-(cyclohexyloxyl)-4-nitrophenyl]-methane sulfonamide	134-190	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-115
18664589-7	2008	Collectively, t-BOOH induces PKA-related anion secretion through two independent pathways: rapid activation of apical anion efflux through a COX-2-dependent/cytoskeleton-independent pathway and relatively delayed activation of NKCC1 for basolateral anion uptake through a COX-2-independent/cytoskeleton-dependent pathway.	t-booh	14-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	141-146
18664589-7	2008	Collectively, t-BOOH induces PKA-related anion secretion through two independent pathways: rapid activation of apical anion efflux through a COX-2-dependent/cytoskeleton-independent pathway and relatively delayed activation of NKCC1 for basolateral anion uptake through a COX-2-independent/cytoskeleton-dependent pathway.	t-booh	14-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	272-277
18953425-5	2008	Consistent with the significantly reduced transcript levels of hyaluronan synthase 2, an enzyme responsible for the total level of hyaluronan secreted by these cells, COX-2 silencing resulted in lower hyaluronan levels secreted in culture medium.	Hyaluronic Acid	63-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	167-172
18953425-5	2008	Consistent with the significantly reduced transcript levels of hyaluronan synthase 2, an enzyme responsible for the total level of hyaluronan secreted by these cells, COX-2 silencing resulted in lower hyaluronan levels secreted in culture medium.	Hyaluronic Acid	131-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	167-172
18243047-0	2008	Synthesis and spectroscopic studies of CoII, NiII, FeIII and ThIV complexes derived from 2,2"-dihydroxy-3,3"-di(carboxymethyl)-1,1"-binaphthyl.	thiv	61-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-43
18243047-0	2008	Synthesis and spectroscopic studies of CoII, NiII, FeIII and ThIV complexes derived from 2,2"-dihydroxy-3,3"-di(carboxymethyl)-1,1"-binaphthyl.	2,2"-dihydroxy-3,3"-di(carboxymethyl)-1,1"	89-131	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-43
18243047-0	2008	Synthesis and spectroscopic studies of CoII, NiII, FeIII and ThIV complexes derived from 2,2"-dihydroxy-3,3"-di(carboxymethyl)-1,1"-binaphthyl.	1,1'-binaphthyl	132-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-43
18931730-0	2008	Isomorphous CoII and MnII materials of tetrazolate-5-carboxylate with an unprecedented self-penetrating net and distinct magnetic behaviours.	tetrazolate-5-carboxylate	39-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-16
18931730-1	2008	Two isomorphous Co(II) and Mn(II) three-dimensional coordination polymers with tetrazolate-5-carboxylate as magnetic mediator exhibit an unprecedented 3,4-connected self-penetrating net topology; a combination of canted antiferromagnetism and metamagnetism was observed in the Co(II) compound, whereas the Mn(II) compound shows typical antiferromagnetic behaviors.	Manganese(2+)	27-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	277-283
18931730-1	2008	Two isomorphous Co(II) and Mn(II) three-dimensional coordination polymers with tetrazolate-5-carboxylate as magnetic mediator exhibit an unprecedented 3,4-connected self-penetrating net topology; a combination of canted antiferromagnetism and metamagnetism was observed in the Co(II) compound, whereas the Mn(II) compound shows typical antiferromagnetic behaviors.	Polymers	65-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	277-283
18931730-1	2008	Two isomorphous Co(II) and Mn(II) three-dimensional coordination polymers with tetrazolate-5-carboxylate as magnetic mediator exhibit an unprecedented 3,4-connected self-penetrating net topology; a combination of canted antiferromagnetism and metamagnetism was observed in the Co(II) compound, whereas the Mn(II) compound shows typical antiferromagnetic behaviors.	tetrazolate-5-carboxylate	79-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-22
18931730-1	2008	Two isomorphous Co(II) and Mn(II) three-dimensional coordination polymers with tetrazolate-5-carboxylate as magnetic mediator exhibit an unprecedented 3,4-connected self-penetrating net topology; a combination of canted antiferromagnetism and metamagnetism was observed in the Co(II) compound, whereas the Mn(II) compound shows typical antiferromagnetic behaviors.	tetrazolate-5-carboxylate	79-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	277-283
18931730-1	2008	Two isomorphous Co(II) and Mn(II) three-dimensional coordination polymers with tetrazolate-5-carboxylate as magnetic mediator exhibit an unprecedented 3,4-connected self-penetrating net topology; a combination of canted antiferromagnetism and metamagnetism was observed in the Co(II) compound, whereas the Mn(II) compound shows typical antiferromagnetic behaviors.	Manganese(2+)	306-312	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-22
18811164-6	2008	The influence of the transition metal is studied by changing Fe (II) for Co (II), Co (III), and Fe (III).	Metals	32-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-80
18811164-6	2008	The influence of the transition metal is studied by changing Fe (II) for Co (II), Co (III), and Fe (III).	fe (ii)	61-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-80
18554781-9	2008	We also observed that HS-1200 decreased the levels of cyclooxygenase (COX)-2 mRNA and protein expression.	HS 1200	22-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-76
18554781-10	2008	Furthermore, HS-1200 treatment markedly induced the Egr-1 expression at an early time point, and the increased expression levels of p53, p21 WAF1/CIP1, p27 KIP1, and COX-2 after treatment with HS-1200 were completely inhibited in HepG2 cells and partially inhibited in Hep3B cells by silencing of Egr-1, respectively.	HS 1200	13-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	166-171
18554781-10	2008	Furthermore, HS-1200 treatment markedly induced the Egr-1 expression at an early time point, and the increased expression levels of p53, p21 WAF1/CIP1, p27 KIP1, and COX-2 after treatment with HS-1200 were completely inhibited in HepG2 cells and partially inhibited in Hep3B cells by silencing of Egr-1, respectively.	HS 1200	193-200	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	166-171
18718465-0	2008	Heterotypic contact reveals a COX-2-mediated suppression of osteoblast differentiation by endothelial cells: A negative modulatory role for prostanoids in VEGF-mediated cell: cell communication?	Prostaglandins	140-151	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-35
18718465-3	2008	In this study we have examined: (i) the effects of exogenous PGE(2) on VEGF-driven events in ECs, and (ii) the role of endogenous COX-2-derived prostanoids in mediating communication between intimately opposed OBs and ECs in direct contact.	Prostaglandins	144-155	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	130-135
18718465-4	2008	Exposure of ECs to PGE(2) increased ERK1/2 phosphorylation, COX-2 induction, 6-keto-PGF(1alpha) release and EC proliferation.	Prostaglandins E	19-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-65
18718465-6	2008	However, the COX-2-selective inhibitor, NS398, also attenuated VEGF-induced proliferation, implying a distinct role for endogenous COX-2 activity in regulating EC behaviour.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	40-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
18718465-8	2008	These studies showed that COX-2 blockade with NS398 enhanced EC-dependent increases in OB differentiation, that this effect was reversed by exogenous PGH(2) (immediate COX-2 product), and that exogenous VEGF did not influence EC-dependent OB differentiation under these conditions.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	46-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-31
18718465-8	2008	These studies showed that COX-2 blockade with NS398 enhanced EC-dependent increases in OB differentiation, that this effect was reversed by exogenous PGH(2) (immediate COX-2 product), and that exogenous VEGF did not influence EC-dependent OB differentiation under these conditions.	GH2 protein, human	150-153	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-31
18718465-8	2008	These studies showed that COX-2 blockade with NS398 enhanced EC-dependent increases in OB differentiation, that this effect was reversed by exogenous PGH(2) (immediate COX-2 product), and that exogenous VEGF did not influence EC-dependent OB differentiation under these conditions.	GH2 protein, human	150-153	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	168-173
18712860-6	2008	The synthesis of the new bis-iminopyrrolyl five-coordinate Co(II) complexes [Co(kappa (2) N, N"-NC 4H 3C(R)N-2,6- (i)Pr 2C 6H 3) 2(THF)] (R = H 4a; Me 4b) were carried out in high yields (ca.	bis-iminopyrrolyl	25-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
18712860-6	2008	The synthesis of the new bis-iminopyrrolyl five-coordinate Co(II) complexes [Co(kappa (2) N, N"-NC 4H 3C(R)N-2,6- (i)Pr 2C 6H 3) 2(THF)] (R = H 4a; Me 4b) were carried out in high yields (ca.	4h	99-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
18712860-6	2008	The synthesis of the new bis-iminopyrrolyl five-coordinate Co(II) complexes [Co(kappa (2) N, N"-NC 4H 3C(R)N-2,6- (i)Pr 2C 6H 3) 2(THF)] (R = H 4a; Me 4b) were carried out in high yields (ca.	tetrahydrofuran	131-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
18958425-0	2008	Regulation of lysophosphatidic acid-induced COX-2 expression by ERK1/2 activation in cultured feline esophageal epithelial cells.	lysophosphatidic acid	14-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-49
18958425-2	2008	We investigated the signaling mechanisms underlying LPA-induced COX-2 expression in primary cultures of feline esophageal epithelial cells.	lysophosphatidic acid	52-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-69
18958425-4	2008	Western blot analysis revealed a concentration-and time-dependent induction of COX-2 in response to LPA.	lysophosphatidic acid	100-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-84
18958425-6	2008	LPA-induced COX-2 expression was significantly attenuated by the MEK inhibitor, PD98059, but not by the JNK inhibitor, SP600125, or the p38 MAPK inhibitor, SB212090.	lysophosphatidic acid	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-17
18958425-6	2008	LPA-induced COX-2 expression was significantly attenuated by the MEK inhibitor, PD98059, but not by the JNK inhibitor, SP600125, or the p38 MAPK inhibitor, SB212090.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	80-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-17
18958425-7	2008	LPA-induced COX-2 expression was repressed by pertussis toxin, GF109204X, and Ki16425, indicating the involvements of PTX-sensitive G(i/o) protein, PKC, and the LPA(1/3) receptor, respectively.	ptx	118-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-17
18440802-0	2008	Catalysts of Cu(II) and Co(II) ions adsorbed in chitosan used in transesterification of soy bean and babassu oils - a new route for biodiesel syntheses.	babassu oils	101-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-30
18798061-5	2008	LY294002 could reduce COX-2 induce cells viability, migration and proliferation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-27
18829529-2	2008	However, the use of COX-2 inhibitors has side effects and health hazards; thus, targeting its major metabolite prostaglandin E(2) (PGE(2))-mediated signaling pathway might be a rational approach for the next generation of cancer management.	Dinoprostone	111-129	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-25
18829529-2	2008	However, the use of COX-2 inhibitors has side effects and health hazards; thus, targeting its major metabolite prostaglandin E(2) (PGE(2))-mediated signaling pathway might be a rational approach for the next generation of cancer management.	Dinoprostone	131-137	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-25
18829529-8	2008	Our data suggest that targeting PGE(2) signaling pathway (i.e., blocking EP2 and EP4 receptors) might be a rational therapeutic approach for overcoming the side effects of COX-2 inhibitors and that this might be a novel strategy for the next generation of prostate cancer management.	Dinoprostone	32-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	172-177
18844676-9	2008	The quantitative correlations derived in this paper are useful in predicting the protein binding of coxibs and may help in the design of cox-2 inhibitors with appropriate HSA binding properties.	Altretamine	171-174	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-142
18657281-10	2008	Tetraethylammonium (TEA), a potassium channel blocker, and nimodipine, a calcium channel blocker, both attenuated CT from inducing COX-2 gene expression.	Tetraethylammonium	0-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-136
18657281-0	2008	LY294002 inhibits glucocorticoid-induced COX-2 gene expression in cardiomyocytes through a phosphatidylinositol 3 kinase-independent mechanism.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-46
18657281-10	2008	Tetraethylammonium (TEA), a potassium channel blocker, and nimodipine, a calcium channel blocker, both attenuated CT from inducing COX-2 gene expression.	Tetraethylammonium	20-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-136
18657281-2	2008	While investigating whether phosphatidylinositol 3 kinase (PI3K) plays a role in corticosterone (CT)-induced COX-2, we found that LY294002 (LY29) but not wortmannin (WM) attenuates CT from inducing COX-2 gene expression.	Corticosterone	81-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-114
18657281-10	2008	Tetraethylammonium (TEA), a potassium channel blocker, and nimodipine, a calcium channel blocker, both attenuated CT from inducing COX-2 gene expression.	Nimodipine	59-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-136
18657281-2	2008	While investigating whether phosphatidylinositol 3 kinase (PI3K) plays a role in corticosterone (CT)-induced COX-2, we found that LY294002 (LY29) but not wortmannin (WM) attenuates CT from inducing COX-2 gene expression.	Corticosterone	97-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-114
18657281-12	2008	These data suggest a possible role of calcium instead of PI3K in CT-induced COX-2 expression in cardiomyocytes.	Calcium	38-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-81
18657281-2	2008	While investigating whether phosphatidylinositol 3 kinase (PI3K) plays a role in corticosterone (CT)-induced COX-2, we found that LY294002 (LY29) but not wortmannin (WM) attenuates CT from inducing COX-2 gene expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	130-138	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	198-203
18657281-12	2008	These data suggest a possible role of calcium instead of PI3K in CT-induced COX-2 expression in cardiomyocytes.	Corticosterone	65-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-81
18657281-5	2008	LY303511 (LY30), a structural analogue and a negative control for PI3K inhibitory activity of LY29, also suppressed COX-2 induction.	LY 303511	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-121
18657281-5	2008	LY303511 (LY30), a structural analogue and a negative control for PI3K inhibitory activity of LY29, also suppressed COX-2 induction.	LY 303511	0-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-121
18657281-6	2008	These data suggest PI3K-independent mechanisms in regulating CT-induced COX-2 expression.	Corticosterone	61-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
19209280-2	2008	However, their use has unravelled the important protective role of COX-2 for the cardiovascular (CV) system, mainly through the generation of prostacyclin.	Epoprostenol	142-154	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-72
19209280-4	2008	The increased incidence of thrombotic events associated with profound inhibition of COX-2-dependent prostacyclin by coxibs and tNSAIDs can be mitigated, even if not obliterated, by a complete suppression of platelet COX-1 activity.	Epoprostenol	100-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-89
19209280-7	2008	We will describe possible strategies to reduce the side effects of etoricoxib by using biochemical markers of COX inhibition, such as whole blood COX-2 and the assessment of prostacyclin biosynthesis in vivo.	Etoricoxib	67-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	146-151
18601905-6	2008	The abrogation of apoptosis is completely reversed by specific COX-2 inhibition, suggesting that HBx blocks p53-induced apoptosis via activation of COX-2/PGE(2) pathway.	Prostaglandins E	154-157	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-68
19080641-12	2008	When the concentration of EGCG was over 200microg/ml, it down-regulated the expression of COX-2 and Bcl-2 in both cell lines, however, EGCG resulted in no significant changes of Bcl-xl, Bax, Bad, and Bid.	epigallocatechin gallate	26-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-95
19080641-13	2008	CONCLUSION: EGCG induces apoptosis in HCC cells through down-regulation of COX-2 and Bcl-2 and consequently activating caspase-9 and caspase-3.	epigallocatechin gallate	12-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
18601905-6	2008	The abrogation of apoptosis is completely reversed by specific COX-2 inhibition, suggesting that HBx blocks p53-induced apoptosis via activation of COX-2/PGE(2) pathway.	Prostaglandins E	154-157	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	148-153
18674517-0	2008	Characterization of eltenac and novel COX-2 selective thiopheneacetic acid analogues in vitro and in vivo.	2-thienylacetic acid	54-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-43
18717564-1	2008	A mixed-valence Co(II)/Co(III) heptanuclear wheel [Co(II)3Co(III)4(L)6(MeO)6] (LH2 = 1,1,1-trifluoro-7-hydroxy-4-methyl-5-aza-hept-3-en-2-one) has been synthesized and its crystal structure determined using single-crystal X-ray diffraction.	LH2	79-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-22
18717564-1	2008	A mixed-valence Co(II)/Co(III) heptanuclear wheel [Co(II)3Co(III)4(L)6(MeO)6] (LH2 = 1,1,1-trifluoro-7-hydroxy-4-methyl-5-aza-hept-3-en-2-one) has been synthesized and its crystal structure determined using single-crystal X-ray diffraction.	1,1,1-trifluoro-7-hydroxy-4-methyl-5-aza-hept-3-en-2-one	85-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-22
18674517-13	2008	These properties may also have an impact on the transient inhibition of COX-2-dependent prostacyclin, thereby being less associated with vascular complications.	Epoprostenol	88-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
18674517-4	2008	With COX-1/COX-2 ratios between 7.5- and 16-fold they are in the range of Celecoxib (13-fold).	Celecoxib	74-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-16
18674517-9	2008	Molecular modeling of selective thiopheneacetic acid derivatives to the active site of human COX-2 suggested similar binding properties as Lumiracoxib and Diclofenac.	2-thienylacetic acid	32-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-98
18674517-9	2008	Molecular modeling of selective thiopheneacetic acid derivatives to the active site of human COX-2 suggested similar binding properties as Lumiracoxib and Diclofenac.	lumiracoxib	139-150	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-98
18674517-9	2008	Molecular modeling of selective thiopheneacetic acid derivatives to the active site of human COX-2 suggested similar binding properties as Lumiracoxib and Diclofenac.	Diclofenac	155-165	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-98
18674517-10	2008	In summary, modification of Eltenac generates moderately selective COX-2 drugs in the range of Celecoxib with respect to potency and selectivity.	Celecoxib	95-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-72
18674517-12	2008	Thiopheneacetic derivatives are characterized by low pK(a) values, short microsomal half-lives and binding mode to COX-2 similar to Diclofenac and Lumiracoxib.	thiopheneacetic	0-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-120
18700754-1	2008	The hydrothermal preparation, crystal structure determination, and magnetic study of two isomers made up of 1,2,4,5-benzenetetracarboxylate and high-spin Co(II) ions of formula [Co2(bta)(H2O)4]n x 2n H2O (1 and 2; H4bta = 1,2,4,5-benzenetetracarboxylic acid) are reported.	co2(bta)(h2o)4	178-192	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	154-160
18794140-1	2008	Defects in antitumor immune responses have been associated with increased release of prostaglandin E(2) (PGE(2)) as a result of overexpression of cyclooxygenase (COX)-2 by tumors.	Dinoprostone	85-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	146-168
18794140-1	2008	Defects in antitumor immune responses have been associated with increased release of prostaglandin E(2) (PGE(2)) as a result of overexpression of cyclooxygenase (COX)-2 by tumors.	Dinoprostone	105-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	146-168
18700754-4	2008	The computed values of the exchange coupling between the Co(II) ions across anti-syn carboxylate (1) and syn-syn carboxylate/water (2) bridges are J = -0.060 (1) and -1.90 (2) cm(-1) (with the Hamiltonian being defined as H = -Jsigma(i,j)S(i) x S(j)).	carboxylate	85-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-63
18700754-4	2008	The computed values of the exchange coupling between the Co(II) ions across anti-syn carboxylate (1) and syn-syn carboxylate/water (2) bridges are J = -0.060 (1) and -1.90 (2) cm(-1) (with the Hamiltonian being defined as H = -Jsigma(i,j)S(i) x S(j)).	carboxylate	113-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-63
18700754-4	2008	The computed values of the exchange coupling between the Co(II) ions across anti-syn carboxylate (1) and syn-syn carboxylate/water (2) bridges are J = -0.060 (1) and -1.90 (2) cm(-1) (with the Hamiltonian being defined as H = -Jsigma(i,j)S(i) x S(j)).	Water	125-130	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-63
19024358-3	2008	These task specific ionic liquids have been used for the formation of metal chelates with Cu(II), Ni(II) and Co(II) in aqueous solutions.	Metals	70-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-115
18479189-0	2008	GPx2 counteracts PGE2 production by dampening COX-2 and mPGES-1 expression in human colon cancer cells.	Dinoprostone	17-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
21200991-1	2008	In the title complex, [Co(C(7)H(4)BrO(2))(2)(H(2)O)(2)], the Co(II) ion, which lies on a crystallographic inversion center, is coordin-ated by four O atoms from two bidentate 4-bromo-2-formyl-phenolate ligands and two O atoms from two water ligands in a slightly distorted octa-hedral environment.	co(c(7)h(4)bro(2))	23-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-67
21200991-1	2008	In the title complex, [Co(C(7)H(4)BrO(2))(2)(H(2)O)(2)], the Co(II) ion, which lies on a crystallographic inversion center, is coordin-ated by four O atoms from two bidentate 4-bromo-2-formyl-phenolate ligands and two O atoms from two water ligands in a slightly distorted octa-hedral environment.	Water	45-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-67
21200991-1	2008	In the title complex, [Co(C(7)H(4)BrO(2))(2)(H(2)O)(2)], the Co(II) ion, which lies on a crystallographic inversion center, is coordin-ated by four O atoms from two bidentate 4-bromo-2-formyl-phenolate ligands and two O atoms from two water ligands in a slightly distorted octa-hedral environment.	4-bromo-2-formyl-phenolate	175-201	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-67
21200991-1	2008	In the title complex, [Co(C(7)H(4)BrO(2))(2)(H(2)O)(2)], the Co(II) ion, which lies on a crystallographic inversion center, is coordin-ated by four O atoms from two bidentate 4-bromo-2-formyl-phenolate ligands and two O atoms from two water ligands in a slightly distorted octa-hedral environment.	Water	235-240	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-67
21200991-1	2008	In the title complex, [Co(C(7)H(4)BrO(2))(2)(H(2)O)(2)], the Co(II) ion, which lies on a crystallographic inversion center, is coordin-ated by four O atoms from two bidentate 4-bromo-2-formyl-phenolate ligands and two O atoms from two water ligands in a slightly distorted octa-hedral environment.	octa-hedral	273-284	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-67
18781025-1	2008	The present paper reports on the application of modified multiwalled carbon nanotubes (MMWCNTs) as a new, easily prepared and stable solid sorbent for the preconcentration of trace Co(II) in aqueous solution.	Carbon	69-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	181-187
18781025-10	2008	The method was applied to the determination of Co(II) in water, biological and standard samples.	Water	57-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-53
18479189-10	2008	It is concluded that GPx2 by compartmentalized removal of hydroperoxides silences COX-2 activity and suppresses PGE(2)-dependent COX-2 expression.	Hydrogen Peroxide	58-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
18479189-10	2008	It is concluded that GPx2 by compartmentalized removal of hydroperoxides silences COX-2 activity and suppresses PGE(2)-dependent COX-2 expression.	Hydrogen Peroxide	58-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-134
18479189-10	2008	It is concluded that GPx2 by compartmentalized removal of hydroperoxides silences COX-2 activity and suppresses PGE(2)-dependent COX-2 expression.	Dinoprostone	112-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-134
18759268-6	2008	The production of PGE(2) was inhibited via a 70-90% suppression of COX-2 expression and enzyme activity (P &lt; 0.05).	Dinoprostone	18-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-72
18759268-12	2008	These beneficial effects of resveratrol are due, in part, to its capacity to inhibit COX-2-derived PGE(2) synthesis.	Resveratrol	28-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-90
18759268-12	2008	These beneficial effects of resveratrol are due, in part, to its capacity to inhibit COX-2-derived PGE(2) synthesis.	Dinoprostone	99-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-90
18642283-7	2008	CONCLUSIONS: COX-2, functionally coordinated with mPGES-1, is likely to be the limiting enzyme in PGE(2) biosynthesis in HNSCC.	Dinoprostone	98-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
18556441-10	2008	Furthermore, the crude extract of cannabis containing mainly CBDA was shown to have a selective inhibitory effect on COX-2.	cannabidiolic acid	61-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-122
18556441-1	2008	In the present study it was revealed that cannabidiolic acid (CBDA) selectively inhibited cyclooxygenase (COX)-2 activity with an IC(50) value (50% inhibition concentration) around 2 microM, having 9-fold higher selectivity than COX-1 inhibition.	cannabidiolic acid	42-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-112
18556441-1	2008	In the present study it was revealed that cannabidiolic acid (CBDA) selectively inhibited cyclooxygenase (COX)-2 activity with an IC(50) value (50% inhibition concentration) around 2 microM, having 9-fold higher selectivity than COX-1 inhibition.	cannabidiolic acid	62-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-112
18556441-2	2008	In contrast, Delta(9)-tetrahydrocannabinolic acid (Delta(9)-THCA) was a much less potent inhibitor of COX-2 (IC(50) &gt; 100 microM).	delta(9)-tetrahydrocannabinolic acid	13-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-107
18556441-2	2008	In contrast, Delta(9)-tetrahydrocannabinolic acid (Delta(9)-THCA) was a much less potent inhibitor of COX-2 (IC(50) &gt; 100 microM).	delta(9)-tetrahydrocannabinolic acid	51-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-107
18556441-3	2008	Nonsteroidal anti-inflammatory drugs containing a carboxyl group in their chemical structures such as salicylic acid are known to inhibit nonselectively both COX-1 and COX-2.	Salicylic Acid	102-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	168-173
18556441-5	2008	Thus, the structural requirements for the CBDA-mediated COX-2 inhibition were next studied.	cannabidiolic acid	42-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-61
18556441-7	2008	It was assumed that the whole structure of CBDA is important for COX-2 selective inhibition because beta-resorcylic acid itself did not inhibit COX-2 activity.	cannabidiolic acid	43-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-70
18556441-8	2008	Methylation of the carboxylic acid moiety of CBDA led to disappearance of COX-2 selectivity.	Carboxylic Acids	19-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
18556441-8	2008	Methylation of the carboxylic acid moiety of CBDA led to disappearance of COX-2 selectivity.	cannabidiolic acid	45-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
18556441-11	2008	Taken together, these lines of evidence in this study suggest that naturally occurring CBDA in cannabis is a selective inhibitor for COX-2.	cannabidiolic acid	87-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	133-138
18642283-9	2008	Our results support the notion that mPGES-1, cPGES, and EP-1 could be the targets for the development of specific PGE(2)-modifier drugs for HNSCC treatment that could avoid negative side effects of COX-2 selective inhibitors.	Dinoprostone	114-120	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	198-203
18678399-9	2008	Celecoxib, a COX-2 inhibitor was evaluated in an RTOG study in combination with cisplatin and flourouracil with radiation therapy with no apparent effect on DFS and poor rates of locoregional control.	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
18550688-6	2008	In intact interleukin-1beta-treated A549 cells, licofelone potently (IC(50) &lt; 1 microM) blocked formation of PGE(2) in response to calcimycin (A23187) plus exogenous arachidonic acid, but the concomitant generation of 6-keto PGF(1alpha), used as a biomarker for COX-2 activity, was not inhibited.	licofelone	48-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	265-270
18459145-9	2008	These results suggest a FN-alpha(5)beta(1)/FAK/p38 MAPK dependent upregulation of COX-2 causing a shift in the relative levels of PGs in HUVECs which contributes to the angiogenic effect of FN.	Prostaglandins	130-133	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
18408893-7	2008	OT blocked the COX-2 expression induced by phorbol 12-myristate 13-acetate in a dose-dependent manner and induced apoptosis in HT-29 cancer cells, and suppressed iNOS activation in RAW264.7 macrophages.	Tetradecanoylphorbol Acetate	43-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-20
18818458-1	2008	In the skeleton, prostaglandins, mainly PGE(2) produced by osteoblasts under COX-2 stimulation, play either a stimulatory or an inhibitory role in bone metabolism, depending on the physiological or pathological conditions.	Prostaglandins	17-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-82
18818458-1	2008	In the skeleton, prostaglandins, mainly PGE(2) produced by osteoblasts under COX-2 stimulation, play either a stimulatory or an inhibitory role in bone metabolism, depending on the physiological or pathological conditions.	Prostaglandins E	40-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-82
18695918-4	2008	The IC50 for CDDP was 4.3 microM in KB/COX-2 and 1.7 microM in KB/neo.	Cisplatin	13-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-50
18695918-5	2008	Treatment with small interfering RNA (siRNA) mediated the inhibition of COX-2 significantly increasing the level of susceptibility to CDDP in COX-2 siRNA as compared to that of the control siRNA.	Cisplatin	134-138	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
18695918-5	2008	Treatment with small interfering RNA (siRNA) mediated the inhibition of COX-2 significantly increasing the level of susceptibility to CDDP in COX-2 siRNA as compared to that of the control siRNA.	Cisplatin	134-138	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	142-147
18695918-7	2008	In addition, apoptosis induction by CDDP was at a lower level in KB/COX-2 (31%) than in KB/neo (38%).	Cisplatin	36-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-73
18513776-3	2008	In this study, we characterized the transcriptional and posttranscriptional events that regulate COX-2 expression in a human bronchial epithelial cell line BEAS-2B exposed to Zn2+.	Zinc	175-179	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
18695918-8	2008	These results suggested that the overexpression of COX-2 increases the intracellular production of MRP1 and MRP2 and causes drug resistance to CDDP.	Cisplatin	143-147	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-56
18581209-5	2008	RESULTS: The chronic exposure of Caco-2 to indomethacin heptyl ester (indo HE) (0.4 muM) or nimesulide (10 muM) (selective COX-2 inhibitors) and naproxen (6 muM) (non selective inhibitor COX-1/COX-2) significantly decreased the expression and activity of P-gp.	nimesulide	92-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-128
17964848-0	2008	Synthesis and characterization of Co(II), Ni(II), Cu(II) and Zn(II) complexes of tridentate Schiff base derived from vanillin and DL-alpha-aminobutyric acid.	Zinc	61-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-40
17964848-0	2008	Synthesis and characterization of Co(II), Ni(II), Cu(II) and Zn(II) complexes of tridentate Schiff base derived from vanillin and DL-alpha-aminobutyric acid.	Schiff Bases	92-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-40
17964848-0	2008	Synthesis and characterization of Co(II), Ni(II), Cu(II) and Zn(II) complexes of tridentate Schiff base derived from vanillin and DL-alpha-aminobutyric acid.	vanillin	117-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-40
17964848-0	2008	Synthesis and characterization of Co(II), Ni(II), Cu(II) and Zn(II) complexes of tridentate Schiff base derived from vanillin and DL-alpha-aminobutyric acid.	alpha-aminobutyric acid	130-156	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-40
17964848-1	2008	Co(II), Ni(II), Cu(II) and Zn(II) complexes of the Schiff base derived from vanillin and dl-alpha-aminobutyric acid were synthesized and characterized by elemental analysis, IR, electronic spectra, conductance measurements, magnetic measurements, powder XRD and biological activity.	Schiff Bases	51-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
17964848-1	2008	Co(II), Ni(II), Cu(II) and Zn(II) complexes of the Schiff base derived from vanillin and dl-alpha-aminobutyric acid were synthesized and characterized by elemental analysis, IR, electronic spectra, conductance measurements, magnetic measurements, powder XRD and biological activity.	vanillin	76-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
17964848-1	2008	Co(II), Ni(II), Cu(II) and Zn(II) complexes of the Schiff base derived from vanillin and dl-alpha-aminobutyric acid were synthesized and characterized by elemental analysis, IR, electronic spectra, conductance measurements, magnetic measurements, powder XRD and biological activity.	alpha-aminobutyric acid	89-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
17964848-8	2008	Magnetic measurements show that Co(II), Ni(II) and Cu(II) complexes have paramagnetic behaviour.	cu(ii)	51-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-38
18513776-4	2008	Zn2+ exposure resulted in pronounced increases in COX-2 mRNA and protein expression, which were prevented by pretreatment with the transcription inhibitor actinomycin D, implying the involvement of transcriptional regulation.	Zinc	0-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-55
18513776-4	2008	Zn2+ exposure resulted in pronounced increases in COX-2 mRNA and protein expression, which were prevented by pretreatment with the transcription inhibitor actinomycin D, implying the involvement of transcriptional regulation.	Dactinomycin	155-168	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-55
18513776-5	2008	This was supported by the observation of increased COX-2 promoter activity in Zn2+-treated BEAS-2B cells.	Zinc	78-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-56
18513776-6	2008	Mutation of the cAMP response element (CRE), but not the kappaB-binding sites in the COX-2 promoter markedly reduced COX-2 promoter activity induced by Zn2+.	Zinc	152-156	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-90
18513776-6	2008	Mutation of the cAMP response element (CRE), but not the kappaB-binding sites in the COX-2 promoter markedly reduced COX-2 promoter activity induced by Zn2+.	Zinc	152-156	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-122
18513776-8	2008	Measurement of mRNA stability demonstrated that Zn2+ exposure impaired the degradation of COX-2 mRNA in BEAS-2B cells.	Zinc	48-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-95
18513776-9	2008	This message stabilization effect of Zn2+ exposure was shown to be dependent on the integrity of the 3"-untranslated region found in the COX-2 transcript.	Zinc	37-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-142
18513776-10	2008	Taken together, these data demonstrate that the CRE and mRNA stability regulates COX-2 expression induced in BEAS-2B cells exposed to extracellular Zn2+.	Zinc	148-152	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-86
18571623-1	2008	Previous studies from this laboratory have demonstrated that a COX-2 metabolite of the endogenous cannabinoid, 2-arachidonyl glycerol (2-AG), inhibits IL-2 secretion in activated T cells through PPARgamma activation independent of the cannabinoid receptors, CB1/CB2.	Cannabinoids	98-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-68
18671383-1	2008	We report the cosynthesis of highly stable laminated single crystal alpha- and beta-Co(OH) 2 using the reaction and diffusion of a hydroxide solution into a gel containing Co(II).	Carbonic Acid	84-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	172-178
18671383-1	2008	We report the cosynthesis of highly stable laminated single crystal alpha- and beta-Co(OH) 2 using the reaction and diffusion of a hydroxide solution into a gel containing Co(II).	hydroxide ion	131-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	172-178
18633528-0	2008	2, 3-Diaryl-5-ethylsulfanylmethyltetrahydrofurans as a new class of COX-2 inhibitors and cytotoxic agents.	2, 3-diaryl-5-ethylsulfanylmethyltetrahydrofurans	0-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-73
18571623-1	2008	Previous studies from this laboratory have demonstrated that a COX-2 metabolite of the endogenous cannabinoid, 2-arachidonyl glycerol (2-AG), inhibits IL-2 secretion in activated T cells through PPARgamma activation independent of the cannabinoid receptors, CB1/CB2.	glyceryl 2-arachidonate	111-133	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-68
18571623-1	2008	Previous studies from this laboratory have demonstrated that a COX-2 metabolite of the endogenous cannabinoid, 2-arachidonyl glycerol (2-AG), inhibits IL-2 secretion in activated T cells through PPARgamma activation independent of the cannabinoid receptors, CB1/CB2.	glyceryl 2-arachidonate	135-139	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-68
18571623-3	2008	Pretreatment with nonselective and COX-2-specific inhibitors completely abrogated 2-AG-mediated suppression of IL-2 secretion.	glyceryl 2-arachidonate	82-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40
18571623-7	2008	Furthermore, COX-2 protein and mRNA levels are significantly increased over basal levels by 2h following activation of Jurkat cells, whereas increases in COX-2 protein in murine splenocytes are not observed until 4h after cellular activation.	Deuterium	92-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
18571623-8	2008	These studies suggest that the potency of AEA in the suppression of IL-2 secretion may correlate with COX-2 protein levels in different T cell models.	aea	42-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-107
18394023-9	2008	RA counteracted the inflammatory regulation of cyclooxygenase (COX)-2 mRNA and protein in astrocytes and thereby reduced the synthesis of PGE(2) by approximately 60%.	Tretinoin	0-2	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-69
18571623-0	2008	A COX-2 metabolite of the endogenous cannabinoid, 2-arachidonyl glycerol, mediates suppression of IL-2 secretion in activated Jurkat T cells.	Cannabinoids	37-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	2-7
18571623-0	2008	A COX-2 metabolite of the endogenous cannabinoid, 2-arachidonyl glycerol, mediates suppression of IL-2 secretion in activated Jurkat T cells.	glyceryl 2-arachidonate	50-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	2-7
18495142-8	2008	Meanwhile, FTIR and XPS analyses revealed that chemical functional groups (e.g., alcoholic and carboxylate) on aerobic granules would be the active binding sites for biosorption of Co(II) and Zn(II).	carboxylate	95-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	181-187
18538411-2	2008	The structures and spectroscopic properties of new Mn(II), Co(II), Cd(II), Hg(II), Ag(I), Rh(III), and Ir(I) complexes with the ligand BZLMH derived from 6-acetyl-1,3,7-trimethyllumazine (lumazine=pteridine-2,4(1H,3H)-dione) and benzohydrazide are reported.	bzlmh	135-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
18802217-2	2008	This may hold true for other systems because long term use of selective COX-2 inhibitors such as VIOXX and BEXTRA was associated with heart failure, leading to their withdrawal.	rofecoxib	97-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
18802217-2	2008	This may hold true for other systems because long term use of selective COX-2 inhibitors such as VIOXX and BEXTRA was associated with heart failure, leading to their withdrawal.	valdecoxib	107-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
18812631-8	2008	Aspirin-triggered lipoxin synthesis, via COX-2, acts to reduce the severity of damage induced by this drug.	Aspirin	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-46
18812633-5	2008	Selective NSAIDs were specifically designed to preferentially inhibit the cyclooxygenase-2 (COX-2), an inducible enzyme mediating the production of inflammatory eicosanoids in the joints but sparing the endogenous protective eicosanoids in the stomach.	Eicosanoids	161-172	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-97
18812633-5	2008	Selective NSAIDs were specifically designed to preferentially inhibit the cyclooxygenase-2 (COX-2), an inducible enzyme mediating the production of inflammatory eicosanoids in the joints but sparing the endogenous protective eicosanoids in the stomach.	Eicosanoids	225-236	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-97
18665070-1	2008	OBJECTIVES: There is strong evidence for an important role of cyclooxygenase (COX) 2 and COX-2-generated PGE2 during pancreatic tumorigenesis.	Dinoprostone	105-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-94
18665070-4	2008	Although the benefits of COX-2 inhibition may eventually outweigh the associated cardiovascular risks, there are a number of alternative targets for inhibiting the formation of PGE2 in human tumors that may prove less harmful to the patient.	Dinoprostone	177-181	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-30
18340449-9	2008	Inhibition of the p38 pathway in the presence of GLN substantially explains the chondroprotective effect of GLN on chondrocytes that regulate COX-2 expression, PGE(2) synthesis, and NO expression and synthesis.	Glucosamine	108-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	142-147
18606461-3	2008	This has continued with the suspension of the sale of the COX-2 inhibitors rofecoxib, valdecoxib and lumiracoxib, whereas others (e.g. celecoxib and etoricoxib) are still available.	rofecoxib	75-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
18606461-3	2008	This has continued with the suspension of the sale of the COX-2 inhibitors rofecoxib, valdecoxib and lumiracoxib, whereas others (e.g. celecoxib and etoricoxib) are still available.	lumiracoxib	101-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
18671849-5	2008	Inhibition or knockdown of COX-2 was achieved by treating NSCLC cells with specific COX-2 inhibitor NS-398 or COX-2 siRNA, respectively.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	100-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-32
18671849-5	2008	Inhibition or knockdown of COX-2 was achieved by treating NSCLC cells with specific COX-2 inhibitor NS-398 or COX-2 siRNA, respectively.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	100-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-89
18671849-5	2008	Inhibition or knockdown of COX-2 was achieved by treating NSCLC cells with specific COX-2 inhibitor NS-398 or COX-2 siRNA, respectively.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	100-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-89
18671849-10	2008	We tested these cell lines with a potent specific COX-2 inhibitor NS-398 at concentrations of 0.02, 0.2, 2, 20 microM for 24 or 48 h. The COX-2 activity was reduced in a dose-dependent fashion as shown by reduced PGE2 production.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	66-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-55
18671849-10	2008	We tested these cell lines with a potent specific COX-2 inhibitor NS-398 at concentrations of 0.02, 0.2, 2, 20 microM for 24 or 48 h. The COX-2 activity was reduced in a dose-dependent fashion as shown by reduced PGE2 production.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	66-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	138-143
18671849-10	2008	We tested these cell lines with a potent specific COX-2 inhibitor NS-398 at concentrations of 0.02, 0.2, 2, 20 microM for 24 or 48 h. The COX-2 activity was reduced in a dose-dependent fashion as shown by reduced PGE2 production.	Dinoprostone	213-217	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-55
18671849-10	2008	We tested these cell lines with a potent specific COX-2 inhibitor NS-398 at concentrations of 0.02, 0.2, 2, 20 microM for 24 or 48 h. The COX-2 activity was reduced in a dose-dependent fashion as shown by reduced PGE2 production.	Dinoprostone	213-217	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	138-143
18671849-11	2008	VEGF was significantly reduced following the treatment of NS-398 in A549 (by 31%) and MOR/P (by 47%) cells lines which expressing strong COX-2, but not in H460 cell line which expressing very low COX-2.	Nitrogen	58-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-142
18671849-11	2008	VEGF was significantly reduced following the treatment of NS-398 in A549 (by 31%) and MOR/P (by 47%) cells lines which expressing strong COX-2, but not in H460 cell line which expressing very low COX-2.	Nitrogen	58-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	196-201
18427544-4	2008	In contrast, downregulating RBM3 in HCT116 colon cancer cells with specific siRNA decreases cell growth in culture, which was partially overcome when treated with prostaglandin E(2), a product of cyclooxygenase (COX)-2 enzyme activity.	Dinoprostone	163-181	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	196-218
18571826-5	2008	We analyzed COX-1, COX-2 and cPLA(2) steady state mRNA levels for 100-400 microM PPD after 2-24 h and found clear COX-2 induction for 400 microM PPD after 24 h, while cPLA(2) and COX-1 levels were increased dose-dependently between 8 and 24 h. Increased expression was accompanied by enhanced prostaglandin E(2) and F(2alpha) formation.	Prostaglandins E	293-308	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-119
18650379-0	2008	S-nitrosylation/activation of COX-2 mediates NMDA neurotoxicity.	N-Methylaspartate	45-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-35
18650379-4	2008	Selective disruption of nNOS-COX-2 binding prevents NMDA neurotoxicity.	N-Methylaspartate	52-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34
18615209-0	2008	Assembly of a two-dimensional oxalate-bridged heterometallic Co(II)(3)Cr(III)(2) coordination polymer.	Oxalates	30-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-67
18615209-0	2008	Assembly of a two-dimensional oxalate-bridged heterometallic Co(II)(3)Cr(III)(2) coordination polymer.	tris(1,10-phenanthroline)chromium(III) chloride	70-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-67
18563879-0	2008	Mechanism of single metal exchange in the reactions of [M4(SPh)10]2- (M = Zn or Fe) with CoX2 (X = Cl or NO3) or FeCl2.	Metals	20-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-93
18563879-0	2008	Mechanism of single metal exchange in the reactions of [M4(SPh)10]2- (M = Zn or Fe) with CoX2 (X = Cl or NO3) or FeCl2.	Zinc	74-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-93
18563879-0	2008	Mechanism of single metal exchange in the reactions of [M4(SPh)10]2- (M = Zn or Fe) with CoX2 (X = Cl or NO3) or FeCl2.	Iron	80-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-93
18563879-8	2008	Similar studies on the analogous reactions between [Fe4(SPh)10](2-) and an excess of CoX2 (X = NO3 or Cl) in MeCN exhibit simpler kinetics but these are also consistent with the same mechanism.	fe4(sph)10	52-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-89
18563879-8	2008	Similar studies on the analogous reactions between [Fe4(SPh)10](2-) and an excess of CoX2 (X = NO3 or Cl) in MeCN exhibit simpler kinetics but these are also consistent with the same mechanism.	acetonitrile	109-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-89
21203031-2	2008	The coordination environment around the Co(II) center could be described as a distorted octa-hedron consisting of three N donors from the facially coordinating triaza macrocyclic ligand, one O donor from dimethyl-formamide and two Cl(-) ions.	triaza	160-166	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-46
21203031-2	2008	The coordination environment around the Co(II) center could be described as a distorted octa-hedron consisting of three N donors from the facially coordinating triaza macrocyclic ligand, one O donor from dimethyl-formamide and two Cl(-) ions.	Dimethylformamide	204-222	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-46
18445468-2	2008	Attempts to prepare Co(II)-substituted L1 using biological incorporation resulted in an enzyme that contained only 1 Eq of cobalt and exhibited no catalytic activity.	Cobalt	123-129	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-26
18445468-3	2008	Co(II)-substituted L1 could be prepared by refolding metal-free L1 in the presence of Co(II), and the resulting enzyme contained 1.8 Eq of cobalt, yielded a UV-Vis spectrum consistent with 5-coordinate Co(II), and exhibited a k(cat) of 63 s(-1) and K(m) of 20 microM when using nitrocefin as the substrate.	Metals	53-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
18445468-3	2008	Co(II)-substituted L1 could be prepared by refolding metal-free L1 in the presence of Co(II), and the resulting enzyme contained 1.8 Eq of cobalt, yielded a UV-Vis spectrum consistent with 5-coordinate Co(II), and exhibited a k(cat) of 63 s(-1) and K(m) of 20 microM when using nitrocefin as the substrate.	Cobalt	139-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
18445468-3	2008	Co(II)-substituted L1 could be prepared by refolding metal-free L1 in the presence of Co(II), and the resulting enzyme contained 1.8 Eq of cobalt, yielded a UV-Vis spectrum consistent with 5-coordinate Co(II), and exhibited a k(cat) of 63 s(-1) and K(m) of 20 microM when using nitrocefin as the substrate.	nitrocefin	278-288	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
18445468-4	2008	Pre-steady-state fluorescence and UV-Vis studies demonstrated that refolded, Co(II)-substituted L1 uses the same kinetic mechanism as Zn(II)-containing L1, in which a reaction intermediate is formed when using nitrocefin as substrate.	nitrocefin	210-220	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-83
18445468-5	2008	The described refolding strategy can be used to prepare other Co(II)-substituted Zn(II)-metalloenzymes, particularly those that contain a solvent-exposable disulfide, which often causes oxidation of Co(II) to Co(III).	Zinc	81-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-68
18445468-5	2008	The described refolding strategy can be used to prepare other Co(II)-substituted Zn(II)-metalloenzymes, particularly those that contain a solvent-exposable disulfide, which often causes oxidation of Co(II) to Co(III).	Zinc	81-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	199-205
18445468-5	2008	The described refolding strategy can be used to prepare other Co(II)-substituted Zn(II)-metalloenzymes, particularly those that contain a solvent-exposable disulfide, which often causes oxidation of Co(II) to Co(III).	Disulfides	156-165	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-68
18445468-5	2008	The described refolding strategy can be used to prepare other Co(II)-substituted Zn(II)-metalloenzymes, particularly those that contain a solvent-exposable disulfide, which often causes oxidation of Co(II) to Co(III).	Disulfides	156-165	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	199-205
18642438-0	2008	Retraction notice to "Determination of Co(II) in water and soil samples using spectrophotometry coupled with preconcentration on 4-amino methyl pyridine anchored silica gel column" [J.	Water	49-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-45
18642438-0	2008	Retraction notice to "Determination of Co(II) in water and soil samples using spectrophotometry coupled with preconcentration on 4-amino methyl pyridine anchored silica gel column" [J.	4-pyridylmethylamine	129-152	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-45
18642438-0	2008	Retraction notice to "Determination of Co(II) in water and soil samples using spectrophotometry coupled with preconcentration on 4-amino methyl pyridine anchored silica gel column" [J.	Silicon Dioxide	162-168	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-45
18329216-1	2008	Nimesulide, a Cox-2 inhibitor anti-inflammatory drug, is a light sensitive compound and its biological activity is decreased upon photodegradation.	nimesulide	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
18599975-2	2008	The Co(II) centers are connected by benzene-1,3-dicarboxylate (m-BDC) anions, giving two types of linear chains, which are further joined via meso-helical 1,1"-[2,2"-oxybis(ethane-2,1-diyl)]di-1H-imidazole ligands to yield a thick two-dimensional slab.	benzene-1,3-dicarboxylate (m-bdc)	36-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
18599975-2	2008	The Co(II) centers are connected by benzene-1,3-dicarboxylate (m-BDC) anions, giving two types of linear chains, which are further joined via meso-helical 1,1"-[2,2"-oxybis(ethane-2,1-diyl)]di-1H-imidazole ligands to yield a thick two-dimensional slab.	meso-helical 1,1"-[2,2"-oxybis(ethane-2,1-diyl)]di-1h-imidazole	142-205	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
18522627-1	2008	AIM: To develop a pain relief model for a cyclooxygenase (COX)-2 inhibitor, CS-706, that permits prediction of doses for acute pain relief in Japanese and Western populations.	apricoxib	76-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-64
18462443-5	2008	METHODS: Cultured skin fibroblasts from patients with SSc were treated with retinoids (9-cis-, 13-cis- and all-trans-retinoic acid) and their effect on the expression of cyclooxygenase (COX)-2, connective tissue growth factor (CTGF) and type I and III collagen and on the production of PGE(2) was examined.	Retinoids	76-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	170-192
18462443-6	2008	COX-2 expression was analysed by western immunoblotting, PGE(2) production by enzyme immunoassay and CTGF expression, and type I and III collagen expression by reverse transcriptase PCR and western immunoblotting.	Prostaglandins E	57-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
18462443-9	2008	CONCLUSION: In vitro, 9-cis-RA induced COX-2 expression and PGE(2) production in SSc fibroblasts and PGE(2) downregulated CTGF expression, leading to the inhibition of type I and III collagen synthesis.	Alitretinoin	22-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-44
17996335-1	2008	Co(II) and Ni(II) complexes with 4,6-di-tert-butyl-3-[(2-hydroxyethyl)thio]benzene-1,2-diol (L) have been synthesized and characterized by means of elemental analysis, TG/DTA, FT-IR, ESR, UV-vis, XRD, magnetic susceptibility, cyclic voltammetry and conductance measurements.	1,2-Benzenediol, 4,6-bis(1,1-dimethylethyl)-3-[(2-hydroxyethyl)thio]-	33-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
17996335-1	2008	Co(II) and Ni(II) complexes with 4,6-di-tert-butyl-3-[(2-hydroxyethyl)thio]benzene-1,2-diol (L) have been synthesized and characterized by means of elemental analysis, TG/DTA, FT-IR, ESR, UV-vis, XRD, magnetic susceptibility, cyclic voltammetry and conductance measurements.	deoxythymidylyl-3'-5'-deoxyadenylate	171-174	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
18549814-5	2008	The annual incidence of NSAID-associated upper gastrointestinal (GI) complications such as bleeding is approximately 1%-1.5%; and reductions in these complications have been demonstrated with misoprostol, proton pump inhibitors (PPIs) (only documented in high-risk patients), and COX-2 selective inhibitors.	Misoprostol	192-203	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	280-285
20046772-1	2008	Rofecoxib, a practically insoluble cox-2 selective nonsteroidal antiinflammatory agent was subjected to improvement in solubility by preparing its binary mixtures with beta cyclodextrin using various methods such as physical mixing, co-grinding, kneading with aqueous methanol and co-evaporation from methanol-water mixture.	rofecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40
18442828-6	2008	pH dependent studies have revealed that Fe(III) was adsorbed efficiently at high acidic condition (pH approximately 1.5) compared to Fe(II), Co(II) and Ni(II), while temperature did not have significant effect on the adsorption processes.	ferric sulfate	40-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	141-147
18163459-5	2008	On the other hand even a high concentration of the COX-2 specific inhibitor rofecoxib (500 microM) did not inhibit growth of SW480 cells.	rofecoxib	76-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-56
18493808-0	2008	2-Chlorohexadecanal and 2-chlorohexadecanoic acid induce COX-2 expression in human coronary artery endothelial cells.	2-chlorohexadecanal	0-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-62
18493808-0	2008	2-Chlorohexadecanal and 2-chlorohexadecanoic acid induce COX-2 expression in human coronary artery endothelial cells.	2-chlorohexadecanoic acid	24-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-62
18493808-2	2008	We tested the hypothesis that 2-ClHDA and its metabolites, 2-chlorohexadecanoic acid (2-ClHA) and 2-chlorohexadecanol (2-ClHOH), induce COX-2 expression in human coronary artery endothelial cells (HCAEC).	2-chlorohexadecanal	30-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	136-141
18493808-2	2008	We tested the hypothesis that 2-ClHDA and its metabolites, 2-chlorohexadecanoic acid (2-ClHA) and 2-chlorohexadecanol (2-ClHOH), induce COX-2 expression in human coronary artery endothelial cells (HCAEC).	2-chlorohexadecanoic acid	59-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	136-141
18493808-2	2008	We tested the hypothesis that 2-ClHDA and its metabolites, 2-chlorohexadecanoic acid (2-ClHA) and 2-chlorohexadecanol (2-ClHOH), induce COX-2 expression in human coronary artery endothelial cells (HCAEC).	2-chlorohexadecanoic acid	86-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	136-141
18493808-2	2008	We tested the hypothesis that 2-ClHDA and its metabolites, 2-chlorohexadecanoic acid (2-ClHA) and 2-chlorohexadecanol (2-ClHOH), induce COX-2 expression in human coronary artery endothelial cells (HCAEC).	2-chlorohexadecanol	98-117	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	136-141
18389471-4	2008	The bioassay-guided fractionation led to the isolation of linoleic acid (the IC50 for COX-1 was 85 microm and 0.6 microM for COX-2) and alpha-linolenic acid (the IC50 for COX-1 was 52 microM and 12 microM for COX-2).	Linoleic Acid	58-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-130
18389471-4	2008	The bioassay-guided fractionation led to the isolation of linoleic acid (the IC50 for COX-1 was 85 microm and 0.6 microM for COX-2) and alpha-linolenic acid (the IC50 for COX-1 was 52 microM and 12 microM for COX-2).	Linoleic Acid	58-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	209-214
18389471-4	2008	The bioassay-guided fractionation led to the isolation of linoleic acid (the IC50 for COX-1 was 85 microm and 0.6 microM for COX-2) and alpha-linolenic acid (the IC50 for COX-1 was 52 microM and 12 microM for COX-2).	alpha-Linolenic Acid	136-156	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	209-214
18389471-5	2008	The COX-2/COX-1 ratio was 0.007 for linoleic acid and 0.2 for alpha-linolenic acid.	Linoleic Acid	36-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
18389471-5	2008	The COX-2/COX-1 ratio was 0.007 for linoleic acid and 0.2 for alpha-linolenic acid.	alpha-Linolenic Acid	62-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
18448481-7	2008	In contrast, maximal (17-fold) up-regulation of COX-2, with corresponding COX-2-dependent PG production, occurred 4 h after BCP crystal stimulation.	pg	90-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-53
18448481-7	2008	In contrast, maximal (17-fold) up-regulation of COX-2, with corresponding COX-2-dependent PG production, occurred 4 h after BCP crystal stimulation.	pg	90-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
18448481-7	2008	In contrast, maximal (17-fold) up-regulation of COX-2, with corresponding COX-2-dependent PG production, occurred 4 h after BCP crystal stimulation.	bcp	124-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-53
18448481-11	2008	CONCLUSIONS: These findings indicate that BCP crystals can augment PG production in OASF through induction of COX-1 and COX-2.	bcp	42-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-125
18448481-13	2008	These data add to the evidence suggesting that the constitutive COX-1/inducible COX-2 concept is an over-simplification and suggest that non-selective COX inhibition may be preferable to COX-2 selective inhibition in BCP crystal-associated OA.	bcp	217-220	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-85
18400268-2	2008	METHODS: We performed immunohistochemistry for COX-2 on paraffin-embedded tumors of UCUUT specimens from 79 patients.	Paraffin	56-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
18423412-10	2008	These results imply that inhibition of NADPH oxidase-related oxidative stress by honokiol suppresses the HG-induced NF-kappaB-regulated COX-2 upregulation, apoptosis, and cell death in HUVECs, which has the potential to be developed as a therapeutic agent to prevent hyperglycemia-induced endothelial damage.	honokiol	81-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	136-141
18498876-14	2008	In a functional assay, we found that COX2 expression correlated with increased resistance to doxorubicin.	Doxorubicin	93-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-41
18498876-16	2008	CONCLUSIONS: We found that COX2 expression in MCF7 breast cancer cells induced genomic instability, BCL2 expression, and doxorubicin resistance, thus making them significantly more tumorigenic.	Doxorubicin	121-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-31
18411276-7	2008	LTE(4)-mediated COX-2 induction, PGD(2) generation, and ERK phosphorylation were all sensitive to interference by the PPARgamma antagonist GW9662 and to targeted knockdown of PPARgamma.	2-chloro-5-nitrobenzanilide	139-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-21
18424438-1	2008	In this study, we demonstrate that treatment of human lung adenocarcinoma H460 cells with farnesol induces the expression of a number of immune response and inflammatory genes, including IL-6, CXCL3, IL-1alpha, and COX-2.	Farnesol	90-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	215-220
18424438-8	2008	Knockdown of MEK1/2 or MSK1 expression inhibits farnesol-induced expression of CXCL3, IL-1alpha, and COX-2 mRNA.	Farnesol	48-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-106
18549505-13	2008	Curcumin and resveratrol treatment inhibited NF-kappaB activation and resulted in a reduction of TNF-alpha, IL-1beta, IL-6, and COX-2 gene expression (IC50 = 2 muM) and a reduction of secreted IL-6 and PGE2 (IC50 ~ 20 muM).	Curcumin	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	128-133
18549505-13	2008	Curcumin and resveratrol treatment inhibited NF-kappaB activation and resulted in a reduction of TNF-alpha, IL-1beta, IL-6, and COX-2 gene expression (IC50 = 2 muM) and a reduction of secreted IL-6 and PGE2 (IC50 ~ 20 muM).	Resveratrol	13-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	128-133
18478140-0	2008	Maleate-fumarate conversion and other novel aspects of the reaction of a Co(II) maleate with pyridine and bipyridine.	maleate-fumarate	0-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-79
18478140-0	2008	Maleate-fumarate conversion and other novel aspects of the reaction of a Co(II) maleate with pyridine and bipyridine.	pyridine	93-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-79
18478140-0	2008	Maleate-fumarate conversion and other novel aspects of the reaction of a Co(II) maleate with pyridine and bipyridine.	2,2'-Dipyridyl	106-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-79
18478153-4	2008	This compound is a spin-canted antiferromagnet (weak ferromagnet) with Tc = 18 K. Although Co(II) and Ni(II) ions have different spin values, the spin-canted structure can be formed because of the accidental compensation of their magnetic moments.	Technetium	71-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-97
18541831-10	2008	For individual NSAIDs, current use of the nonselective naproxen (HR, 2.63; 95% CI, 1.47-4.72) and the COX-2-selective rofecoxib (HR, 3.38; 95% CI, 1.48-7.74) was associated with a greater risk of stroke.	rofecoxib	118-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-107
21202733-2	2008	The Co(II) center is six-coordinated by four N atoms from one bis-[4-(2-pyrid-yl)pyrimidin-2-yl] sulfide (L) ligand and two bromide anions, forming an octa-hedral coordination geometry, where the four donor N atoms are located in the equatorial plane and the Br atoms occupy the axial positions.	Nitrogen	45-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
21202733-2	2008	The Co(II) center is six-coordinated by four N atoms from one bis-[4-(2-pyrid-yl)pyrimidin-2-yl] sulfide (L) ligand and two bromide anions, forming an octa-hedral coordination geometry, where the four donor N atoms are located in the equatorial plane and the Br atoms occupy the axial positions.	bis-[4-(2-pyrid-yl)pyrimidin-2-yl] sulfide	62-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
21202733-2	2008	The Co(II) center is six-coordinated by four N atoms from one bis-[4-(2-pyrid-yl)pyrimidin-2-yl] sulfide (L) ligand and two bromide anions, forming an octa-hedral coordination geometry, where the four donor N atoms are located in the equatorial plane and the Br atoms occupy the axial positions.	Bromides	124-131	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
21202733-2	2008	The Co(II) center is six-coordinated by four N atoms from one bis-[4-(2-pyrid-yl)pyrimidin-2-yl] sulfide (L) ligand and two bromide anions, forming an octa-hedral coordination geometry, where the four donor N atoms are located in the equatorial plane and the Br atoms occupy the axial positions.	Nitrogen	207-208	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
21202733-2	2008	The Co(II) center is six-coordinated by four N atoms from one bis-[4-(2-pyrid-yl)pyrimidin-2-yl] sulfide (L) ligand and two bromide anions, forming an octa-hedral coordination geometry, where the four donor N atoms are located in the equatorial plane and the Br atoms occupy the axial positions.	Bromine	259-261	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
18434017-0	2008	Does COX2-dependent PGE2 play a role in neuropathic pain?	Dinoprostone	20-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	5-9
18434017-6	2008	Cyclooxygenase 2-dependent prostaglandin E2 (COX2/PGE2) is one of the important mediator abundantly produced in injured nerves and involved in the genesis of NeP.	Dinoprostone	27-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-49
18434017-6	2008	Cyclooxygenase 2-dependent prostaglandin E2 (COX2/PGE2) is one of the important mediator abundantly produced in injured nerves and involved in the genesis of NeP.	Dinoprostone	50-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-49
18434017-9	2008	COX2/PGE2 may also induce chronic effects on local inflammatory cells in injured nerves to facilitate the synthesis of inflammatory mediators via autocrine and paracrine pathways.	Dinoprostone	5-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-4
18386923-1	2008	The tripodal system [1]3+ forms a 1:1 complex with CoII in which the metal is octahedrally coordinated by three bpy fragments.	Metals	69-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-55
18493808-2	2008	We tested the hypothesis that 2-ClHDA and its metabolites, 2-chlorohexadecanoic acid (2-ClHA) and 2-chlorohexadecanol (2-ClHOH), induce COX-2 expression in human coronary artery endothelial cells (HCAEC).	2-clhoh	119-126	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	136-141
18493808-3	2008	COX-2 protein expression increased in response to 2-ClHDA treatments at 8 and 20 h. 2-ClHA also increased COX-2 expression following an 8 h treatment.	2-chlorohexadecanal	50-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
18493808-3	2008	COX-2 protein expression increased in response to 2-ClHDA treatments at 8 and 20 h. 2-ClHA also increased COX-2 expression following an 8 h treatment.	2-chlorohexadecanal	50-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-111
18493808-3	2008	COX-2 protein expression increased in response to 2-ClHDA treatments at 8 and 20 h. 2-ClHA also increased COX-2 expression following an 8 h treatment.	2-chlorohexadecanoic acid	84-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
18493808-3	2008	COX-2 protein expression increased in response to 2-ClHDA treatments at 8 and 20 h. 2-ClHA also increased COX-2 expression following an 8 h treatment.	2-chlorohexadecanoic acid	84-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-111
18493808-4	2008	Quantitative PCR showed that 2-ClHDA treatment increased COX-2 mRNA over 8 h, while 2-ClHA treatment led to a modest increase by 1 h and those levels remained constant over 8 h. 2-ClHDA led to a significant increase in 6-keto-PGF(1alpha) release (a measure of PGI(2) release) by HCAEC.	2-chlorohexadecanal	29-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-62
18493808-4	2008	Quantitative PCR showed that 2-ClHDA treatment increased COX-2 mRNA over 8 h, while 2-ClHA treatment led to a modest increase by 1 h and those levels remained constant over 8 h. 2-ClHDA led to a significant increase in 6-keto-PGF(1alpha) release (a measure of PGI(2) release) by HCAEC.	2-chlorohexadecanal	178-185	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-62
18493808-5	2008	These data suggest that 2-ClHDA and its metabolite 2-ClHA, which are produced during leukocyte activation, may alter vascular endothelial cell function by upregulation of COX-2 expression.	2-chlorohexadecanal	24-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	171-176
18493808-5	2008	These data suggest that 2-ClHDA and its metabolite 2-ClHA, which are produced during leukocyte activation, may alter vascular endothelial cell function by upregulation of COX-2 expression.	2-chlorohexadecanoic acid	51-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	171-176
18386923-1	2008	The tripodal system [1]3+ forms a 1:1 complex with CoII in which the metal is octahedrally coordinated by three bpy fragments.	2,2'-Dipyridyl	112-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-55
18386923-3	2008	X-ray diffraction studies on the crystalline complex salt of formula [CoII(1)...H2O]Cl(PF6)(4).2MeCN have shown that a water molecule is included in the cavity and the water oxygen atom receives six H-bonds from the C-H fragments of the three imidazolium subunits and of the three proximate pyridine rings, according to a slightly distorted trigonal prismatic geometry.	pyridine	291-299	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-74
18386923-3	2008	X-ray diffraction studies on the crystalline complex salt of formula [CoII(1)...H2O]Cl(PF6)(4).2MeCN have shown that a water molecule is included in the cavity and the water oxygen atom receives six H-bonds from the C-H fragments of the three imidazolium subunits and of the three proximate pyridine rings, according to a slightly distorted trigonal prismatic geometry.	Salts	53-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-74
18386923-4	2008	Anion inclusion in an aqueous MeCN solution induces a distinct cathodic shift of the potential of the CoIII/CoII couple, whose magnitude decreases along the series: Cl-&gt;Br- approximately NCO-&gt;I- approximately NCS-, which reflects anion tendencies to receive H-bonds from the receptor.	acetonitrile	30-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-106
18386923-3	2008	X-ray diffraction studies on the crystalline complex salt of formula [CoII(1)...H2O]Cl(PF6)(4).2MeCN have shown that a water molecule is included in the cavity and the water oxygen atom receives six H-bonds from the C-H fragments of the three imidazolium subunits and of the three proximate pyridine rings, according to a slightly distorted trigonal prismatic geometry.	Water	119-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-74
18386923-3	2008	X-ray diffraction studies on the crystalline complex salt of formula [CoII(1)...H2O]Cl(PF6)(4).2MeCN have shown that a water molecule is included in the cavity and the water oxygen atom receives six H-bonds from the C-H fragments of the three imidazolium subunits and of the three proximate pyridine rings, according to a slightly distorted trigonal prismatic geometry.	Water	168-173	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-74
18386923-3	2008	X-ray diffraction studies on the crystalline complex salt of formula [CoII(1)...H2O]Cl(PF6)(4).2MeCN have shown that a water molecule is included in the cavity and the water oxygen atom receives six H-bonds from the C-H fragments of the three imidazolium subunits and of the three proximate pyridine rings, according to a slightly distorted trigonal prismatic geometry.	Oxygen	174-180	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-74
18386923-3	2008	X-ray diffraction studies on the crystalline complex salt of formula [CoII(1)...H2O]Cl(PF6)(4).2MeCN have shown that a water molecule is included in the cavity and the water oxygen atom receives six H-bonds from the C-H fragments of the three imidazolium subunits and of the three proximate pyridine rings, according to a slightly distorted trigonal prismatic geometry.	imidazolium	243-254	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-74
18461927-0	2008	Synthesis and properties of diphenoxo-bridged CoII, NiII, CuII, and ZnII complexes of a new tripodal ligand: generation and properties of MII-coordinated phenoxyl radical species.	diphenoxo	28-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-50
18461927-0	2008	Synthesis and properties of diphenoxo-bridged CoII, NiII, CuII, and ZnII complexes of a new tripodal ligand: generation and properties of MII-coordinated phenoxyl radical species.	Methicillin	138-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-50
18461927-0	2008	Synthesis and properties of diphenoxo-bridged CoII, NiII, CuII, and ZnII complexes of a new tripodal ligand: generation and properties of MII-coordinated phenoxyl radical species.	phenoxy radical	154-170	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-50
18437583-13	2008	Recent studies showed that the use of colloidal nanoparticle formulations and the potent COX 2 inhibitor bromfenac may enhance NSAID efficacy in eye preparations.	bromfenac	105-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-94
18520053-3	2008	We previously reported that intact fecal water samples from human volunteers significantly decreased prostaglandin production and COX-2 protein expression in colonic cells.	Water	41-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	130-135
18441204-8	2008	The HNP-induced COX-2 and ET-1 production was attenuated by the treatment with the oxygen free radical scavenger N-acetyl-L-cysteine and the inhibitors of p38 MAPK and NF-kappaB, respectively.	Oxygen	83-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-21
18441204-8	2008	The HNP-induced COX-2 and ET-1 production was attenuated by the treatment with the oxygen free radical scavenger N-acetyl-L-cysteine and the inhibitors of p38 MAPK and NF-kappaB, respectively.	Acetylcysteine	113-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-21
18489027-1	2008	BACKGROUND: Cyclooxygenase (COX)-2 is an inducible enzyme responsible for catalysing the formation of prostaglandins (PGs) in settings of inflammation.	Prostaglandins	102-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-34
17962941-7	2008	CONCLUSION: We suggest that adaptive T(R) cells contribute to an immunosuppressive microenvironment in CRC and inhibit effector T cells by a COX-2-PGE(2)-dependent mechanism and thereby facilitate tumor growth.	Dinoprostone	147-153	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	141-146
18489027-1	2008	BACKGROUND: Cyclooxygenase (COX)-2 is an inducible enzyme responsible for catalysing the formation of prostaglandins (PGs) in settings of inflammation.	Prostaglandins	118-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-34
18489027-2	2008	Single nucleotide polymorphisms (SNPs) of the COX-2 gene may influence gene transcription and PG production in the asthmatic airway.	Prostaglandins	94-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
24692797-18	2008	The relatively smaller risk for AEs makes the short-term use of COX-2 inhibitors potentially attractive, but the long-term benefits remain unclear.	aes	32-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-69
17882158-0	2008	Modeling and simulation to support dose selection and clinical development of SC-75416, a selective COX-2 inhibitor for the treatment of acute and chronic pain.	SC-75416	78-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-105
18673254-7	2008	The parallel study on the complexation ability of the potassium complex of Monensin A (MonK, 1b) towards Co(II) and Mn(II) showed the formation of the isostructural complexes 2a and 2b accompanied by loss of the potassium ion due to the new coordination mode of the ligand.	Potassium	54-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-111
17714833-6	2008	The orientation of the most potent and selective COX-2 inhibitor of training set, 2-(4-phenyl sulfonamide)-3-phenyl-5-methylindole, in the COX-2 active site was explored by docking.	2-(4-phenyl sulfonamide)-3-phenyl-5-methylindole	82-130	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-144
18325997-12	2008	Our results suggested CRH and CRH-related peptides act on CRH-R1 and CRH-R2 to exert different effects on PG biosynthetic enzymes cPLA2 and COX-2 and thereby modulate output of PGs from placenta, which would be important for controlling pregnancy and parturition.	Prostaglandins	106-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-145
18325997-12	2008	Our results suggested CRH and CRH-related peptides act on CRH-R1 and CRH-R2 to exert different effects on PG biosynthetic enzymes cPLA2 and COX-2 and thereby modulate output of PGs from placenta, which would be important for controlling pregnancy and parturition.	Phosphatidylglycerols	177-180	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-145
17714833-1	2008	In the present work, modelling study has been performed to explore the physicochemical requirements of 2-sulfonyl-phenyl-3-phenyl-indole analogs as COX-2 enzyme inhibitors.	2-sulfonyl-phenyl-3-phenyl-indole	103-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	148-153
17714833-11	2008	Study has revealed that atomic van der Waals volume and atomic masses explain COX-2 inhibitory activity of 2-sulfonyl-phenyl-3-phenyl-indole analogs significantly.	2-sulfonyl-phenyl-3-phenyl-indole	107-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-83
17714833-6	2008	The orientation of the most potent and selective COX-2 inhibitor of training set, 2-(4-phenyl sulfonamide)-3-phenyl-5-methylindole, in the COX-2 active site was explored by docking.	2-(4-phenyl sulfonamide)-3-phenyl-5-methylindole	82-130	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-54
18434566-0	2008	Comparative inhibitory activity of etoricoxib, celecoxib, and diclofenac on COX-2 versus COX-1 in healthy subjects.	Celecoxib	47-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-81
18697608-2	2008	Ibuprofen is a cyclooxygenase (COX-1 and COX-2) inhibitor known to reduce the production of prostaglandins that play prominent role in inflammation.	Ibuprofen	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-46
18697608-2	2008	Ibuprofen is a cyclooxygenase (COX-1 and COX-2) inhibitor known to reduce the production of prostaglandins that play prominent role in inflammation.	Prostaglandins	92-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-46
18697608-9	2008	From the results of present study, it can be concluded that ibuprofen (non-selective COX inhibitor) showed promising antihyperlipidemic, antiatherosclerotic, antioxidant, antiinflammatory and non-ulcerogenic activity in atherosclerotic animals as compared to aspirin (preferential COX-1 inhibitor) and celecoxib (selective COX-2 inhibitors, suggesting the inducible role of COX in atherosclerosis.	Ibuprofen	60-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	323-328
18434566-0	2008	Comparative inhibitory activity of etoricoxib, celecoxib, and diclofenac on COX-2 versus COX-1 in healthy subjects.	Etoricoxib	35-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-81
18434566-0	2008	Comparative inhibitory activity of etoricoxib, celecoxib, and diclofenac on COX-2 versus COX-1 in healthy subjects.	Diclofenac	62-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-81
18083230-0	2008	Imatinib-resistant K562 cells are more sensitive to celecoxib, a selective COX-2 inhibitor: role of COX-2 and MDR-1.	Imatinib Mesylate	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
18083230-0	2008	Imatinib-resistant K562 cells are more sensitive to celecoxib, a selective COX-2 inhibitor: role of COX-2 and MDR-1.	Imatinib Mesylate	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-105
18083230-0	2008	Imatinib-resistant K562 cells are more sensitive to celecoxib, a selective COX-2 inhibitor: role of COX-2 and MDR-1.	Celecoxib	52-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
18083230-4	2008	Further studies revealed the over-expression of COX-2 and MDR-1 in IR-K562 cells suggesting the possible involvement of COX-2 in the development of resistance to imatinib.	Imatinib Mesylate	162-170	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-53
18083230-4	2008	Further studies revealed the over-expression of COX-2 and MDR-1 in IR-K562 cells suggesting the possible involvement of COX-2 in the development of resistance to imatinib.	Imatinib Mesylate	162-170	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-125
18083230-5	2008	So, we sought to examine the effect of celecoxib, a selective COX-2 inhibitor, on IR-K562 cells.	Celecoxib	39-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
18083230-7	2008	This increase in the sensitivity of IR-K562 cells towards celecoxib suggests that the development of resistance in IR-K562 cells is COX-2 dependent.	Celecoxib	58-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-137
18083230-11	2008	In conclusion, the present study indicates over-expression of COX-2 and MDR-1 in IR-K562 cells and celecoxib, a COX-2 specific inhibitor, induces apoptosis by inhibiting COX-2 and down-regulating MDR-1 expression through Akt/p-Akt signaling pathway.	Celecoxib	99-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-117
18083230-11	2008	In conclusion, the present study indicates over-expression of COX-2 and MDR-1 in IR-K562 cells and celecoxib, a COX-2 specific inhibitor, induces apoptosis by inhibiting COX-2 and down-regulating MDR-1 expression through Akt/p-Akt signaling pathway.	Celecoxib	99-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-117
17913572-1	2008	The metal complexes of Cu(II), Ni(II) and Co(II) with Schiff bases of 3-(2-hydroxy-3-ethoxybenzylideneamino)-5-methyl isoxazole [HEBMI] and 3-(2-hydroxy-5-nitrobenzylidene amino)-5-methyl isoxazole [HNBMI] which were obtained by the condensation of 3-amino-5-methyl isoxazole with substituted salicylaldehydes have been synthesized.	Metals	4-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-48
17913572-1	2008	The metal complexes of Cu(II), Ni(II) and Co(II) with Schiff bases of 3-(2-hydroxy-3-ethoxybenzylideneamino)-5-methyl isoxazole [HEBMI] and 3-(2-hydroxy-5-nitrobenzylidene amino)-5-methyl isoxazole [HNBMI] which were obtained by the condensation of 3-amino-5-methyl isoxazole with substituted salicylaldehydes have been synthesized.	cu(ii)	23-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-48
17913572-1	2008	The metal complexes of Cu(II), Ni(II) and Co(II) with Schiff bases of 3-(2-hydroxy-3-ethoxybenzylideneamino)-5-methyl isoxazole [HEBMI] and 3-(2-hydroxy-5-nitrobenzylidene amino)-5-methyl isoxazole [HNBMI] which were obtained by the condensation of 3-amino-5-methyl isoxazole with substituted salicylaldehydes have been synthesized.	Schiff Bases	54-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-48
17913572-1	2008	The metal complexes of Cu(II), Ni(II) and Co(II) with Schiff bases of 3-(2-hydroxy-3-ethoxybenzylideneamino)-5-methyl isoxazole [HEBMI] and 3-(2-hydroxy-5-nitrobenzylidene amino)-5-methyl isoxazole [HNBMI] which were obtained by the condensation of 3-amino-5-methyl isoxazole with substituted salicylaldehydes have been synthesized.	3-(2-hydroxy-3-ethoxybenzylideneamino)-5-methyl isoxazole	70-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-48
17913572-1	2008	The metal complexes of Cu(II), Ni(II) and Co(II) with Schiff bases of 3-(2-hydroxy-3-ethoxybenzylideneamino)-5-methyl isoxazole [HEBMI] and 3-(2-hydroxy-5-nitrobenzylidene amino)-5-methyl isoxazole [HNBMI] which were obtained by the condensation of 3-amino-5-methyl isoxazole with substituted salicylaldehydes have been synthesized.	hebmi	129-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-48
17913572-1	2008	The metal complexes of Cu(II), Ni(II) and Co(II) with Schiff bases of 3-(2-hydroxy-3-ethoxybenzylideneamino)-5-methyl isoxazole [HEBMI] and 3-(2-hydroxy-5-nitrobenzylidene amino)-5-methyl isoxazole [HNBMI] which were obtained by the condensation of 3-amino-5-methyl isoxazole with substituted salicylaldehydes have been synthesized.	3-(2-hydroxy-5-nitrobenzylidene amino)-5-methyl isoxazole	140-197	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-48
17913572-1	2008	The metal complexes of Cu(II), Ni(II) and Co(II) with Schiff bases of 3-(2-hydroxy-3-ethoxybenzylideneamino)-5-methyl isoxazole [HEBMI] and 3-(2-hydroxy-5-nitrobenzylidene amino)-5-methyl isoxazole [HNBMI] which were obtained by the condensation of 3-amino-5-methyl isoxazole with substituted salicylaldehydes have been synthesized.	hnbmi	199-204	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-48
17913572-1	2008	The metal complexes of Cu(II), Ni(II) and Co(II) with Schiff bases of 3-(2-hydroxy-3-ethoxybenzylideneamino)-5-methyl isoxazole [HEBMI] and 3-(2-hydroxy-5-nitrobenzylidene amino)-5-methyl isoxazole [HNBMI] which were obtained by the condensation of 3-amino-5-methyl isoxazole with substituted salicylaldehydes have been synthesized.	3-amino-5-methylisoxazole	249-275	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-48
17913572-1	2008	The metal complexes of Cu(II), Ni(II) and Co(II) with Schiff bases of 3-(2-hydroxy-3-ethoxybenzylideneamino)-5-methyl isoxazole [HEBMI] and 3-(2-hydroxy-5-nitrobenzylidene amino)-5-methyl isoxazole [HNBMI] which were obtained by the condensation of 3-amino-5-methyl isoxazole with substituted salicylaldehydes have been synthesized.	salicylaldehyde	293-309	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-48
19040046-12	2008	In the cases with both COX-2 -765GG and PGIS CC genotypes, the serum 6-keto-PGF1alpha levels was lower than that of others (P &lt; 0.05).	6-Ketoprostaglandin F1 alpha	69-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-28
18327873-5	2008	During differentiation this is reversed, while low calcium enhanced COX-2 protein expression.	Calcium	51-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-73
19040046-14	2008	Populations with both COX-2 -765GG and PGIS CC genotypes were more at risk with MI than others which might be resulted from the decreased serum 6-keto-PGF1alpha concentration.	6-Ketoprostaglandin F1 alpha	144-160	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-27
19024521-9	2008	The expression level of COX-2 and VEGF in the gastric cancer tissues was significantly decreased in the celecoxib group compared with those in the control group (P &lt; 0.05).	Celecoxib	104-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
18390903-1	2008	Sco1 is implicated in the copper metallation of the Cu(A) site in Cox2 of cytochrome oxidase.	Copper	26-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-70
18473059-1	2008	Discrete homo Cu-Cu-Cu and hetero Cu-Pd-Cu or Cu-Co-Cu metal arrays are prepared within an organic-pillared coordination box by inserting M(ii)-azaporphine/porphine cartridges (M = Cu(ii), Pd(ii) or Co(ii)), where the metal arrays show unique spin interactions in ESR: in particular, Deltam(s) = 3 for the Cu-Cu-Cu array.	Copper	14-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-142
18473059-1	2008	Discrete homo Cu-Cu-Cu and hetero Cu-Pd-Cu or Cu-Co-Cu metal arrays are prepared within an organic-pillared coordination box by inserting M(ii)-azaporphine/porphine cartridges (M = Cu(ii), Pd(ii) or Co(ii)), where the metal arrays show unique spin interactions in ESR: in particular, Deltam(s) = 3 for the Cu-Cu-Cu array.	Palladium	37-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-142
18326857-6	2008	Third, the HA/CD44-activated ErbB2 --&gt; phosphoinositide 3-kinase/AKT --&gt; beta-catenin pathway stimulates cell survival/cell proliferation through COX-2 induction in hyaluronan-overexpressing HIEC6 cells and in HCA7 cells.	Hyaluronic Acid	171-181	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-157
18326857-0	2008	Hyaluronan constitutively regulates activation of COX-2-mediated cell survival activity in intestinal epithelial and colon carcinoma cells.	Hyaluronic Acid	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-55
18355441-0	2008	DPPC regulates COX-2 expression in monocytes via phosphorylation of CREB.	1,2-Dipalmitoylphosphatidylcholine	0-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-20
18355441-5	2008	Further, DPPC increased the phosphorylation of the cyclic AMP response element binding protein (CREB; an important nuclear transcription factor important in regulating COX-2 expression).	1,2-Dipalmitoylphosphatidylcholine	9-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	168-173
18485224-1	2008	BACKGROUND: An increasing number of reports is challenging the notion that the antitumor potential of the selective COX-2 inhibitor celecoxib (Celebrex) is mediated primarily via the inhibition of COX-2.	Celecoxib	132-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-121
18355441-5	2008	Further, DPPC increased the phosphorylation of the cyclic AMP response element binding protein (CREB; an important nuclear transcription factor important in regulating COX-2 expression).	Cyclic AMP	51-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	168-173
18355441-6	2008	In addition, we also show that changing the fatty acid groups of PC (e.g. using l-alpha-phosphatidylcholine beta-arachidonoyl-gamma-palmitoyl (PAPC)) has a profound effect on the regulation of COX-2 expression and CREB activation.	Fatty Acids	44-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	193-198
18355441-6	2008	In addition, we also show that changing the fatty acid groups of PC (e.g. using l-alpha-phosphatidylcholine beta-arachidonoyl-gamma-palmitoyl (PAPC)) has a profound effect on the regulation of COX-2 expression and CREB activation.	l-alpha-phosphatidylcholine	80-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	193-198
18355441-6	2008	In addition, we also show that changing the fatty acid groups of PC (e.g. using l-alpha-phosphatidylcholine beta-arachidonoyl-gamma-palmitoyl (PAPC)) has a profound effect on the regulation of COX-2 expression and CREB activation.	1-O-hexadecyl-2-arachidonyl-sn-glycero-3-phosphocholine	143-147	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	193-198
18355441-7	2008	This study provides new evidence for the anti-inflammatory activity of DPPC and that this activity is at least in part mediated via CREB activation of COX-2.	1,2-Dipalmitoylphosphatidylcholine	71-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-156
18493301-8	2008	Co-incubation of Nuc with COX-2-expressing neutrophil lysates also increased their capacity to produce PGE(2).	Prostaglandins E	103-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-31
18493301-10	2008	Together, these results identify a COX-2-associated protein which may have an impact in prostanoid biosynthesis.	Prostaglandins	88-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40
18485224-1	2008	BACKGROUND: An increasing number of reports is challenging the notion that the antitumor potential of the selective COX-2 inhibitor celecoxib (Celebrex) is mediated primarily via the inhibition of COX-2.	Celecoxib	132-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	197-202
18485224-1	2008	BACKGROUND: An increasing number of reports is challenging the notion that the antitumor potential of the selective COX-2 inhibitor celecoxib (Celebrex) is mediated primarily via the inhibition of COX-2.	Celecoxib	143-151	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-121
18485224-1	2008	BACKGROUND: An increasing number of reports is challenging the notion that the antitumor potential of the selective COX-2 inhibitor celecoxib (Celebrex) is mediated primarily via the inhibition of COX-2.	Celecoxib	143-151	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	197-202
18294142-9	2008	Since COX-2 and PGE(2) have been shown to be anti-inflammatory in airway inflammation, the present data suggest a modulating and protective role of LPA in regulating innate immunity and remodelling of the airways.	lysophosphatidic acid	148-151	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	6-11
18294142-3	2008	Treatment with LPA (1 microM) stimulated COX-2 mRNA and protein expression and PGE(2) release via G(alphai)-coupled LPARs (LPA receptors).	lysophosphatidic acid	15-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-46
18294142-5	2008	Downregulation of EGFR by siRNA or pretreatment with the EGFR tyrosine kinase inhibitor, AG1478, partly attenuated LPA-induced COX-2 expression and phosphorylation of C/EBPbeta; however, neither of these factors had an effect on the NF-kappaB and JNK pathways.	RTKI cpd	89-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	127-132
18294142-5	2008	Downregulation of EGFR by siRNA or pretreatment with the EGFR tyrosine kinase inhibitor, AG1478, partly attenuated LPA-induced COX-2 expression and phosphorylation of C/EBPbeta; however, neither of these factors had an effect on the NF-kappaB and JNK pathways.	lysophosphatidic acid	115-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	127-132
18294142-6	2008	Furthermore, LPA-induced EGFR transactivation, phosphorylation of C/EBPbeta and COX-2 expression were attenuated by overexpression of a catalytically inactive mutant of PLD2 [PLD (phospholipase D) 2], PLD2-K758R, or by addition of myristoylated PKCzeta [PKC (protein kinase C) zeta] peptide pseudosubstrate.	lysophosphatidic acid	13-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-85
18485224-2	2008	We have investigated this issue by applying two different analogs of celecoxib that differentially display COX-2-inhibitory activity: the first analog, called unmethylated celecoxib (UMC), inhibits COX-2 slightly more potently than its parental compound, whereas the second analog, 2,5-dimethyl-celecoxib (DMC), has lost the ability to inhibit COX-2.	Celecoxib	172-181	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	198-203
18294142-8	2008	These results demonstrate that LPA induces COX-2 expression and PGE(2) production through EGFR transactivation-independent activation of transcriptional factors NF-kappaB and c-Jun, and EGFR transactivation-dependent activation of C/EBPbeta in HBEpCs.	lysophosphatidic acid	31-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
18485224-2	2008	We have investigated this issue by applying two different analogs of celecoxib that differentially display COX-2-inhibitory activity: the first analog, called unmethylated celecoxib (UMC), inhibits COX-2 slightly more potently than its parental compound, whereas the second analog, 2,5-dimethyl-celecoxib (DMC), has lost the ability to inhibit COX-2.	Celecoxib	172-181	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	198-203
18485224-2	2008	We have investigated this issue by applying two different analogs of celecoxib that differentially display COX-2-inhibitory activity: the first analog, called unmethylated celecoxib (UMC), inhibits COX-2 slightly more potently than its parental compound, whereas the second analog, 2,5-dimethyl-celecoxib (DMC), has lost the ability to inhibit COX-2.	umc	183-186	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	198-203
18461198-2	2008	The mixed single-carboxylate-aromatic amine ligands bridged metal systems display a new structurally authenticated example of a thick 2D layer, and also indicate homometallic Co(II) clusters with Td-Oh-Td mixed-geometries can result in relatively obvious noncompensation moments, according to different efficient spins of Co(II) at very low temperature, in spite of antiferromagnetic intracluster interactions.	carboxylate-aromatic amine	17-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	175-181
18485224-2	2008	We have investigated this issue by applying two different analogs of celecoxib that differentially display COX-2-inhibitory activity: the first analog, called unmethylated celecoxib (UMC), inhibits COX-2 slightly more potently than its parental compound, whereas the second analog, 2,5-dimethyl-celecoxib (DMC), has lost the ability to inhibit COX-2.	umc	183-186	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	198-203
18439834-3	2008	After reduction to the amino group and subsequent coupling with l-phenylalanine or 1-carboxylmethyl-5-fluorouracil (5-Fu acid), the functionalized porphyrins were metallized with Co(II) or Mn(II) to form miscellaneous porphyrins in good yields.	5-fu acid	116-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	179-185
18439834-3	2008	After reduction to the amino group and subsequent coupling with l-phenylalanine or 1-carboxylmethyl-5-fluorouracil (5-Fu acid), the functionalized porphyrins were metallized with Co(II) or Mn(II) to form miscellaneous porphyrins in good yields.	Porphyrins	147-157	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	179-185
18300249-7	2008	As a test of the ability of this function to predict binding for systems not in the training set, the resulting fitted FURSAMA function is then applied to 23 ligands of the COX-2 enzyme.	fursama	119-126	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	173-178
18461198-2	2008	The mixed single-carboxylate-aromatic amine ligands bridged metal systems display a new structurally authenticated example of a thick 2D layer, and also indicate homometallic Co(II) clusters with Td-Oh-Td mixed-geometries can result in relatively obvious noncompensation moments, according to different efficient spins of Co(II) at very low temperature, in spite of antiferromagnetic intracluster interactions.	carboxylate-aromatic amine	17-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	322-328
18461198-2	2008	The mixed single-carboxylate-aromatic amine ligands bridged metal systems display a new structurally authenticated example of a thick 2D layer, and also indicate homometallic Co(II) clusters with Td-Oh-Td mixed-geometries can result in relatively obvious noncompensation moments, according to different efficient spins of Co(II) at very low temperature, in spite of antiferromagnetic intracluster interactions.	Metals	60-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	175-181
18461198-2	2008	The mixed single-carboxylate-aromatic amine ligands bridged metal systems display a new structurally authenticated example of a thick 2D layer, and also indicate homometallic Co(II) clusters with Td-Oh-Td mixed-geometries can result in relatively obvious noncompensation moments, according to different efficient spins of Co(II) at very low temperature, in spite of antiferromagnetic intracluster interactions.	Metals	60-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	322-328
21202475-1	2008	In the title complex, [CoCl(2)(C(21)H(19)N(3))], the Co(II) atom is coordinated by one pyridine and two imine N atoms and by two chloride anions in a distorted trigonal bipyramidal geometry.	cobaltous chloride	23-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-59
18403118-3	2008	COX-2 has attracted significant attention as an important source of oxidative stress in dopaminergic neurons due to its potential to oxidize catechols including dopamine.	Catechols	141-150	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
18403118-3	2008	COX-2 has attracted significant attention as an important source of oxidative stress in dopaminergic neurons due to its potential to oxidize catechols including dopamine.	Dopamine	88-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
18403118-5	2008	Here, we show that COX-2 induces dopamine oxidation, as evidenced by the findings that COX-2 can facilitate dopamine oxidation in a cell-free system and in COX-2-overexpressing SH-SY5Y cells, and that this can be completely abolished by the selective COX-2 inhibitor meloxicam.	Dopamine	33-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-24
18403118-5	2008	Here, we show that COX-2 induces dopamine oxidation, as evidenced by the findings that COX-2 can facilitate dopamine oxidation in a cell-free system and in COX-2-overexpressing SH-SY5Y cells, and that this can be completely abolished by the selective COX-2 inhibitor meloxicam.	Dopamine	33-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-92
18403118-5	2008	Here, we show that COX-2 induces dopamine oxidation, as evidenced by the findings that COX-2 can facilitate dopamine oxidation in a cell-free system and in COX-2-overexpressing SH-SY5Y cells, and that this can be completely abolished by the selective COX-2 inhibitor meloxicam.	Dopamine	33-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-92
18403118-5	2008	Here, we show that COX-2 induces dopamine oxidation, as evidenced by the findings that COX-2 can facilitate dopamine oxidation in a cell-free system and in COX-2-overexpressing SH-SY5Y cells, and that this can be completely abolished by the selective COX-2 inhibitor meloxicam.	Dopamine	33-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-92
18403118-5	2008	Here, we show that COX-2 induces dopamine oxidation, as evidenced by the findings that COX-2 can facilitate dopamine oxidation in a cell-free system and in COX-2-overexpressing SH-SY5Y cells, and that this can be completely abolished by the selective COX-2 inhibitor meloxicam.	Dopamine	108-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-24
18403118-5	2008	Here, we show that COX-2 induces dopamine oxidation, as evidenced by the findings that COX-2 can facilitate dopamine oxidation in a cell-free system and in COX-2-overexpressing SH-SY5Y cells, and that this can be completely abolished by the selective COX-2 inhibitor meloxicam.	Dopamine	108-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-92
18403118-5	2008	Here, we show that COX-2 induces dopamine oxidation, as evidenced by the findings that COX-2 can facilitate dopamine oxidation in a cell-free system and in COX-2-overexpressing SH-SY5Y cells, and that this can be completely abolished by the selective COX-2 inhibitor meloxicam.	Dopamine	108-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-92
18403118-5	2008	Here, we show that COX-2 induces dopamine oxidation, as evidenced by the findings that COX-2 can facilitate dopamine oxidation in a cell-free system and in COX-2-overexpressing SH-SY5Y cells, and that this can be completely abolished by the selective COX-2 inhibitor meloxicam.	Dopamine	108-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-92
18403118-5	2008	Here, we show that COX-2 induces dopamine oxidation, as evidenced by the findings that COX-2 can facilitate dopamine oxidation in a cell-free system and in COX-2-overexpressing SH-SY5Y cells, and that this can be completely abolished by the selective COX-2 inhibitor meloxicam.	Meloxicam	267-276	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-24
18403118-5	2008	Here, we show that COX-2 induces dopamine oxidation, as evidenced by the findings that COX-2 can facilitate dopamine oxidation in a cell-free system and in COX-2-overexpressing SH-SY5Y cells, and that this can be completely abolished by the selective COX-2 inhibitor meloxicam.	Meloxicam	267-276	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-92
18403118-5	2008	Here, we show that COX-2 induces dopamine oxidation, as evidenced by the findings that COX-2 can facilitate dopamine oxidation in a cell-free system and in COX-2-overexpressing SH-SY5Y cells, and that this can be completely abolished by the selective COX-2 inhibitor meloxicam.	Meloxicam	267-276	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-92
18403118-5	2008	Here, we show that COX-2 induces dopamine oxidation, as evidenced by the findings that COX-2 can facilitate dopamine oxidation in a cell-free system and in COX-2-overexpressing SH-SY5Y cells, and that this can be completely abolished by the selective COX-2 inhibitor meloxicam.	Meloxicam	267-276	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-92
18403118-7	2008	These data suggest that an abnormal increase in COX-2 expression causes dopamine oxidation and contributes to the preferential vulnerability of dopaminergic cells as in PD.	Dopamine	72-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-53
21202475-1	2008	In the title complex, [CoCl(2)(C(21)H(19)N(3))], the Co(II) atom is coordinated by one pyridine and two imine N atoms and by two chloride anions in a distorted trigonal bipyramidal geometry.	pyridine	87-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-59
21202475-1	2008	In the title complex, [CoCl(2)(C(21)H(19)N(3))], the Co(II) atom is coordinated by one pyridine and two imine N atoms and by two chloride anions in a distorted trigonal bipyramidal geometry.	Chlorides	129-137	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-59
18443952-2	2008	The aim of our study was to investigate the mechanism of growth inhibitory effect of selective inhibition of COX-2 by NS-398 on human cancer cells.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	118-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-114
18353655-2	2008	N-Hydroxy-4-(5-methyl-3-phenylisoxazol-4-yl)benzenesulfonamide (3)-a primary metabolite of the highly selective COX-2 inhibitor valdecoxib-was synthesized and stabilized as its monohydrate (3a.H(2)O).	UNII-6M6L09OU0A	0-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-117
18353655-2	2008	N-Hydroxy-4-(5-methyl-3-phenylisoxazol-4-yl)benzenesulfonamide (3)-a primary metabolite of the highly selective COX-2 inhibitor valdecoxib-was synthesized and stabilized as its monohydrate (3a.H(2)O).	valdecoxib	128-138	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-117
18353655-2	2008	N-Hydroxy-4-(5-methyl-3-phenylisoxazol-4-yl)benzenesulfonamide (3)-a primary metabolite of the highly selective COX-2 inhibitor valdecoxib-was synthesized and stabilized as its monohydrate (3a.H(2)O).	2,5-dimethyl-4-(morpholin-4-ylmethyl)phenol	177-188	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-117
18473059-1	2008	Discrete homo Cu-Cu-Cu and hetero Cu-Pd-Cu or Cu-Co-Cu metal arrays are prepared within an organic-pillared coordination box by inserting M(ii)-azaporphine/porphine cartridges (M = Cu(ii), Pd(ii) or Co(ii)), where the metal arrays show unique spin interactions in ESR: in particular, Deltam(s) = 3 for the Cu-Cu-Cu array.	co-cu	49-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-142
18473059-1	2008	Discrete homo Cu-Cu-Cu and hetero Cu-Pd-Cu or Cu-Co-Cu metal arrays are prepared within an organic-pillared coordination box by inserting M(ii)-azaporphine/porphine cartridges (M = Cu(ii), Pd(ii) or Co(ii)), where the metal arrays show unique spin interactions in ESR: in particular, Deltam(s) = 3 for the Cu-Cu-Cu array.	Metals	55-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-142
18473059-1	2008	Discrete homo Cu-Cu-Cu and hetero Cu-Pd-Cu or Cu-Co-Cu metal arrays are prepared within an organic-pillared coordination box by inserting M(ii)-azaporphine/porphine cartridges (M = Cu(ii), Pd(ii) or Co(ii)), where the metal arrays show unique spin interactions in ESR: in particular, Deltam(s) = 3 for the Cu-Cu-Cu array.	Metals	55-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	184-186
18473059-1	2008	Discrete homo Cu-Cu-Cu and hetero Cu-Pd-Cu or Cu-Co-Cu metal arrays are prepared within an organic-pillared coordination box by inserting M(ii)-azaporphine/porphine cartridges (M = Cu(ii), Pd(ii) or Co(ii)), where the metal arrays show unique spin interactions in ESR: in particular, Deltam(s) = 3 for the Cu-Cu-Cu array.	Metals	55-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	184-186
18473059-1	2008	Discrete homo Cu-Cu-Cu and hetero Cu-Pd-Cu or Cu-Co-Cu metal arrays are prepared within an organic-pillared coordination box by inserting M(ii)-azaporphine/porphine cartridges (M = Cu(ii), Pd(ii) or Co(ii)), where the metal arrays show unique spin interactions in ESR: in particular, Deltam(s) = 3 for the Cu-Cu-Cu array.	Metals	55-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	199-205
18473059-1	2008	Discrete homo Cu-Cu-Cu and hetero Cu-Pd-Cu or Cu-Co-Cu metal arrays are prepared within an organic-pillared coordination box by inserting M(ii)-azaporphine/porphine cartridges (M = Cu(ii), Pd(ii) or Co(ii)), where the metal arrays show unique spin interactions in ESR: in particular, Deltam(s) = 3 for the Cu-Cu-Cu array.	porphine	144-155	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-142
17624587-1	2008	There is a growing body of evidence that COX-2 expression s a fundamental step in breast cancer pathogenesis acting through prostaglandin-dependent and independent mechanisms.	Prostaglandins	124-137	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-46
18443952-4	2008	Two kinds of cell lines were treated with various concentrations of NS-398 (selective for COX-2 inhibition) at 0.01-0.1 mM for 24 h, 48 h and 72 h. Antiproliferation effect was measured by 3H-TdR incorporation.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	68-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-95
18443952-13	2008	NS-398 could inhibit cell proliferation in cancer cells whether or no COX-2 expression.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	0-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-75
18420277-7	2008	Finally, we briefly review the controversial vascular effects on prostanoid inhibition by COX-2 inhibitors.	Prostaglandins	65-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-95
18395713-1	2008	The conditions used for in vitro differentiation of hMSCs contain substances that affect the activity and expression of cyclooxygenase enzymes (COX1/COX2) and thereby the synthesis of prostanoids.	Prostaglandins	184-195	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	149-153
18456507-1	2008	15-Deoxy-delta12,14-prostaglandin-J(2) (15d-PGJ(2)) has potent anti-inflammatory effects including the inhibition of interleukin-1beta (IL-1beta)-induced expression of cyclooxygenase-2 (COX-2) and prostaglandin E(2) (PGE(2)) production in several cell types.	15-deoxy-delta12,14-prostaglandin-j	0-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	186-191
18355892-3	2008	From batch adsorption tests, the order of selectivity was found to be as follows: Cu(II)&gt;&gt;Fe(III)&gt;Pb(II)&gt;Ni(II)&gt;&gt;Co(II)&gt;Cd(II).	cu(ii)	82-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-137
18355892-5	2008	It was found that mutual separation of Ni(II) from Co(II) and that of Pb(II) from Cd(II) can be achieved at pH 3.	Nickel(2+)	39-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-57
18437081-3	2008	METHODS: The n-6 PUFA arachidonic acid (AA) stimulated the growth of cyclooxygenase (COX) 2 positive human pancreatic cancer (PaCa) cells, which was mediated by COX-2 generated prostaglandin E2 (PGE2) binding to EP2 and EP4 receptors.	n-6 pufa arachidonic acid	13-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-91
18437081-3	2008	METHODS: The n-6 PUFA arachidonic acid (AA) stimulated the growth of cyclooxygenase (COX) 2 positive human pancreatic cancer (PaCa) cells, which was mediated by COX-2 generated prostaglandin E2 (PGE2) binding to EP2 and EP4 receptors.	n-6 pufa arachidonic acid	13-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	161-166
18437081-3	2008	METHODS: The n-6 PUFA arachidonic acid (AA) stimulated the growth of cyclooxygenase (COX) 2 positive human pancreatic cancer (PaCa) cells, which was mediated by COX-2 generated prostaglandin E2 (PGE2) binding to EP2 and EP4 receptors.	Dinoprostone	177-193	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-91
18437081-3	2008	METHODS: The n-6 PUFA arachidonic acid (AA) stimulated the growth of cyclooxygenase (COX) 2 positive human pancreatic cancer (PaCa) cells, which was mediated by COX-2 generated prostaglandin E2 (PGE2) binding to EP2 and EP4 receptors.	Dinoprostone	177-193	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	161-166
18437081-3	2008	METHODS: The n-6 PUFA arachidonic acid (AA) stimulated the growth of cyclooxygenase (COX) 2 positive human pancreatic cancer (PaCa) cells, which was mediated by COX-2 generated prostaglandin E2 (PGE2) binding to EP2 and EP4 receptors.	Dinoprostone	195-199	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-91
18437081-3	2008	METHODS: The n-6 PUFA arachidonic acid (AA) stimulated the growth of cyclooxygenase (COX) 2 positive human pancreatic cancer (PaCa) cells, which was mediated by COX-2 generated prostaglandin E2 (PGE2) binding to EP2 and EP4 receptors.	Dinoprostone	195-199	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	161-166
18437081-4	2008	In contrast, the n-3 PUFA eicosapentaenoic acid decreased the growth of COX-2-positive and COX-2-negative PaCa cells.	n-3 pufa eicosapentaenoic acid	17-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
18437081-4	2008	In contrast, the n-3 PUFA eicosapentaenoic acid decreased the growth of COX-2-positive and COX-2-negative PaCa cells.	n-3 pufa eicosapentaenoic acid	17-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-96
18456507-1	2008	15-Deoxy-delta12,14-prostaglandin-J(2) (15d-PGJ(2)) has potent anti-inflammatory effects including the inhibition of interleukin-1beta (IL-1beta)-induced expression of cyclooxygenase-2 (COX-2) and prostaglandin E(2) (PGE(2)) production in several cell types.	-pgj	43-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	186-191
18456507-3	2008	The present study was devoted to analyze the effect of 15d-PGJ(2) on COX-2 expression in cultured human mesangial cells (HMC).	15-deoxyprostaglandin J2	55-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-74
18456507-5	2008	N-acetylcysteine (NAC), a thiol reducing agent, but not reactive oxygen species scavengers, prevented 15d-PGJ(2)-induced COX-2 up-regulation.	Acetylcysteine	0-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-126
18456507-4	2008	15d-PGJ(2) induced an increase in the reduced glutathione (GSH) content and up-regulated COX-2 protein expression, but not COX-1, in a manner which was unaffected by selective peroxisome proliferator-activated receptor gamma (PPARgamma) blockade nor mimicked by ciglitazone, a PPARgamma agonist.	15d-pgj	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-94
18456507-5	2008	N-acetylcysteine (NAC), a thiol reducing agent, but not reactive oxygen species scavengers, prevented 15d-PGJ(2)-induced COX-2 up-regulation.	15d-pgj	102-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-126
18456507-6	2008	Depletion of GSH by buthionine sulfoximine, which diminishes thiol antioxidant activity, cooperated with 15d-PGJ(2) to accumulate COX-2.	Glutathione	13-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	130-135
18456507-6	2008	Depletion of GSH by buthionine sulfoximine, which diminishes thiol antioxidant activity, cooperated with 15d-PGJ(2) to accumulate COX-2.	Buthionine Sulfoximine	20-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	130-135
18456507-6	2008	Depletion of GSH by buthionine sulfoximine, which diminishes thiol antioxidant activity, cooperated with 15d-PGJ(2) to accumulate COX-2.	Sulfhydryl Compounds	61-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	130-135
18456507-6	2008	Depletion of GSH by buthionine sulfoximine, which diminishes thiol antioxidant activity, cooperated with 15d-PGJ(2) to accumulate COX-2.	15d-pgj	105-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	130-135
18456507-7	2008	Therefore, 15d-PGJ(2) up-regulated COX-2 through a thiol antioxidant-sensitive mechanism.	15d-pgj(	11-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40
18456507-7	2008	Therefore, 15d-PGJ(2) up-regulated COX-2 through a thiol antioxidant-sensitive mechanism.	Sulfhydryl Compounds	51-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40
18456507-9	2008	Up-regulation of COX-2 by 15d-PGJ(2) did not result in increased PGE(2) production.	15d-pgj	26-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22
18442195-1	2008	AIM: To study the effect of 5-lipoxygenase/cyclooxygenase-2 (5-LOX/COX-2) dual inhibitor 7-tert-butyl-2, 3-dihydro-3, 3-dimethyl substituted dihydrofuran 30 (DHDMBF30) on proliferation and apoptosis of the pancreatic cancer cell line Capan-2 and the effect of DHDMBF30 on human pancreatic cancer in a nude mouse model.	7-tert-butyl-2, 3-dihydro-3, 3-dimethyl substituted dihydrofuran	89-153	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-72
18358504-2	2008	RIAA inhibited LPS-stimulated PGE(2) formation with &gt;200-fold selectivity of COX-2 (IC(50)=1.3 microg/ml) over COX-1 (IC(50)&gt;289 microg/ml).	Prostaglandins E	30-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-85
21202222-1	2008	In the mol-ecule of the title compound, [Co(C(6)H(4)NO(2))(2)(H(2)O)(2)], the coordination environment around the Co(II) atom is distorted octahedral; two N and two O atoms of the pyridine-2-carboxylate ligands lie in the equatorial plane and the two water O atoms in the axial positions.	co(c(6)h(4)no(2))	41-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-120
18370379-2	2008	Its chelating coordination ability has been demonstrated by the formation of the corresponding transition metal complexes in the presence of M(OAc)2.nH2O (M = Co(II), Ni(II), Cu(II)) and FeCl3.6H2O.	Metals	106-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	159-165
18370379-2	2008	Its chelating coordination ability has been demonstrated by the formation of the corresponding transition metal complexes in the presence of M(OAc)2.nH2O (M = Co(II), Ni(II), Cu(II)) and FeCl3.6H2O.	m(oac)2.nh2o	141-153	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	159-165
21202222-1	2008	In the mol-ecule of the title compound, [Co(C(6)H(4)NO(2))(2)(H(2)O)(2)], the coordination environment around the Co(II) atom is distorted octahedral; two N and two O atoms of the pyridine-2-carboxylate ligands lie in the equatorial plane and the two water O atoms in the axial positions.	Water	62-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-120
21202222-1	2008	In the mol-ecule of the title compound, [Co(C(6)H(4)NO(2))(2)(H(2)O)(2)], the coordination environment around the Co(II) atom is distorted octahedral; two N and two O atoms of the pyridine-2-carboxylate ligands lie in the equatorial plane and the two water O atoms in the axial positions.	Nitrogen	52-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-120
18414668-5	2008	Expression of IL-32 in influenza A virus infected A549 human lung epithelial cells was blocked by either selective COX-2 inhibitor NS398 or Aspirin, a known anti-inflammatory drug, indicating IL-32 was induced through COX-2 in the inflammatory cascade.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	131-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-120
18414668-6	2008	Interestingly, we found that COX-2-associate PGE(2) production activated by influenza virus infection was significantly suppressed by over-expression of IL-32 but increased by IL-32-specific siRNA, suggesting there was a feedback mechanism between IL-32 and COX-2.	Prostaglandins E	45-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34
18414668-6	2008	Interestingly, we found that COX-2-associate PGE(2) production activated by influenza virus infection was significantly suppressed by over-expression of IL-32 but increased by IL-32-specific siRNA, suggesting there was a feedback mechanism between IL-32 and COX-2.	Prostaglandins E	45-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	258-263
18190940-8	2008	However, the neurotoxic effects of TBC (100 microM) on SH-SY5Y cells were also observed including the decrease in mitochondria membrane potential and the increase in COX-2 expression and cell death.	p-tert-butyl catechol	35-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	166-171
18190940-9	2008	TBC-induced SH-SY5Y cell death was attenuated by pretreatment with NS-398, a selective COX-2 inhibitor.	p-tert-butyl catechol	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-92
18190940-9	2008	TBC-induced SH-SY5Y cell death was attenuated by pretreatment with NS-398, a selective COX-2 inhibitor.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	67-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-92
18190940-11	2008	However, the high concentration of TBC might be toxic, at least in part, for increasing COX-2 expression.	p-tert-butyl catechol	35-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-93
17611104-2	2008	Chemical modification was done by esterification using succinic anhydride followed by activation with NaHCO(3) in order to improve the adsorption of Co(II).	succinic anhydride	55-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	149-155
18261978-5	2008	Furthermore, NSA9 reduced the expression of inducible NO synthase (iNOS) and cyclooxygenase (COX)-2 mRNA and protein, which control the production of NO and PGE(2), respectively.	Prostaglandins E	157-160	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-99
18371146-11	2008	Statins induced apoptosis and enhanced the antiproliferative effect of NS-398, a selective cyclooxygenase (COX)-2 inhibitor.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	71-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-113
17611104-2	2008	Chemical modification was done by esterification using succinic anhydride followed by activation with NaHCO(3) in order to improve the adsorption of Co(II).	Sodium Bicarbonate	102-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	149-155
17963179-3	2008	This is accomplished through inhibition of the endometrial expression of enzymes related to the biosynthesis of prostaglandin and oestrogen, particularly cyclooxygenase type II (Cox-2) and aromatase.	Prostaglandins	112-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	178-183
18395088-1	2008	BACKGROUND &amp; AIMS: Gastrin induces the expression of cyclooxygenase (COX)-2 and interleukin (IL)-8; however, the mechanism(s), especially in gastric epithelial cells, is not well understood.	Adenosine Monophosphate	12-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-79
18395088-11	2008	IL-8 expression was dependent on COX-2-mediated prostaglandin E(2) synthesis.	Dinoprostone	48-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-38
18395100-9	2008	In the more common sporadic setting the APROVe (refecoxib), APC and PreSAP (Celecoxib) trials have shown a significant reduction in adenoma recurrence but important concerns exist regarding cardiovascular toxicity associated with selective COX-2 inhibitors.	Celecoxib	76-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	240-245
18058818-0	2008	The effects of a COX-2 inhibitor meloxicam on squamous cell carcinoma of the esophagus in vivo.	Meloxicam	33-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22
18058818-2	2008	The purpose of this study was to determine if similar changes occurred in vivo in the tumors of patients with SCC of the esophagus who were given a preferential COX-2 inhibitor, meloxicam.	Meloxicam	178-187	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	161-166
18058818-13	2008	We conclude that meloxicam induces apoptosis in SCC of the esophagus in vivo by inhibiting the pathway of NF-kappaB downstream regulation of COX-2.	Meloxicam	17-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	141-146
18397691-13	2008	For both isoenzymes, COX inhibition correlated with naproxen plasma levels (ex vivo IC50 values of 35.48 micromol/l (COX-1) and 64.62 micromol/l (COX-2)).	Naproxen	52-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	146-151
18360718-7	2008	COX-2 predicted tumor tissue content of PGE2 (p&lt;0.002), without reflection in tumor derived blood.	Dinoprostone	40-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
18430566-3	2008	In the preoptic area, the major site controlling male sexual behavior, estradiol increases the level of the COX-2 enzyme and its product, prostaglandin E2 which promotes dendritic spine synaptogenesis.	Estradiol	71-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-113
18430566-3	2008	In the preoptic area, the major site controlling male sexual behavior, estradiol increases the level of the COX-2 enzyme and its product, prostaglandin E2 which promotes dendritic spine synaptogenesis.	Dinoprostone	138-154	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-113
18285354-7	2008	Pre-treatment with the MAPK inhibitors SP600125 (JNK inhibitor), SB202190 (p38 inhibitor) or PD98059 (ERK inhibitor) significantly inhibited AGE-BSA induction of COX-2 expression and production of PGE(2).	pyrazolanthrone	39-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	162-167
18285354-7	2008	Pre-treatment with the MAPK inhibitors SP600125 (JNK inhibitor), SB202190 (p38 inhibitor) or PD98059 (ERK inhibitor) significantly inhibited AGE-BSA induction of COX-2 expression and production of PGE(2).	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	65-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	162-167
18285354-7	2008	Pre-treatment with the MAPK inhibitors SP600125 (JNK inhibitor), SB202190 (p38 inhibitor) or PD98059 (ERK inhibitor) significantly inhibited AGE-BSA induction of COX-2 expression and production of PGE(2).	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	93-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	162-167
18285354-7	2008	Pre-treatment with the MAPK inhibitors SP600125 (JNK inhibitor), SB202190 (p38 inhibitor) or PD98059 (ERK inhibitor) significantly inhibited AGE-BSA induction of COX-2 expression and production of PGE(2).	Prostaglandins E	197-200	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	162-167
18203712-1	2008	Cyclooxygenases (COX-1 and COX-2) are N-glycosylated, endoplasmic reticulum-resident, integral membrane proteins that catalyze the committed step in prostanoid synthesis.	Nitrogen	38-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-32
18203712-1	2008	Cyclooxygenases (COX-1 and COX-2) are N-glycosylated, endoplasmic reticulum-resident, integral membrane proteins that catalyze the committed step in prostanoid synthesis.	Prostaglandins	149-159	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-32
18250160-3	2008	Recent work has uncovered a subtle functional difference between the two enzymes, namely the ability of COX-2 to efficiently utilize neutral derivatives (esters and amides) of arachidonic acid as substrates.	Esters	154-160	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
18250160-3	2008	Recent work has uncovered a subtle functional difference between the two enzymes, namely the ability of COX-2 to efficiently utilize neutral derivatives (esters and amides) of arachidonic acid as substrates.	Amides	165-171	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
18250160-3	2008	Recent work has uncovered a subtle functional difference between the two enzymes, namely the ability of COX-2 to efficiently utilize neutral derivatives (esters and amides) of arachidonic acid as substrates.	Arachidonic Acid	176-192	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
18250160-5	2008	This raises the possibility that COX-2 oxygenation plays a role in a novel signaling pathway dependent on agonist-induced release of endocannabinoids and their selective oxygenation by COX-2.	Endocannabinoids	133-149	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-38
18250160-6	2008	Among the products of COX-2 oxygenation of endocannabinoids are glyceryl prostaglandins, some of which (e.g. glyceryl prostaglandin E(2) and glyceryl prostaglandin I(2)) exhibit interesting biological activities in inflammatory, neurological, and vascular systems.	Endocannabinoids	43-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-27
18250160-6	2008	Among the products of COX-2 oxygenation of endocannabinoids are glyceryl prostaglandins, some of which (e.g. glyceryl prostaglandin E(2) and glyceryl prostaglandin I(2)) exhibit interesting biological activities in inflammatory, neurological, and vascular systems.	glyceryl prostaglandins	64-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-27
18250160-6	2008	Among the products of COX-2 oxygenation of endocannabinoids are glyceryl prostaglandins, some of which (e.g. glyceryl prostaglandin E(2) and glyceryl prostaglandin I(2)) exhibit interesting biological activities in inflammatory, neurological, and vascular systems.	glyceryl prostaglandin e	109-133	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-27
18250160-6	2008	Among the products of COX-2 oxygenation of endocannabinoids are glyceryl prostaglandins, some of which (e.g. glyceryl prostaglandin E(2) and glyceryl prostaglandin I(2)) exhibit interesting biological activities in inflammatory, neurological, and vascular systems.	glyceryl prostaglandin i	141-165	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-27
18096394-2	2008	The 2-nitrooxyethyl ester prodrugs (12a-d) all exhibited in vitro inhibitory activity against the cyclooxygenase-2 (COX-2) isozyme (IC(50)=0.07-2.8 microM range).	2-nitrooxyethyl ester	4-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-121
18278863-0	2008	An unusual asymmetric polyoxomolybdate containing mixed-valence antimony and its derivatives: [Sb4VSb2IIIMo18O73(H2O)2]12- and {M(H2O)2[Sb4VSb2IIIMo18O73(H2O)2]2}22- (M = MnII, FeII, CuII or CoII).	polyoxomolybdate	22-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	191-195
18339887-7	2008	Antiangiogenic effect of silibinin was coupled with a strong decrease in inducible nitric oxide synthase (NOS) and NOS3, cyclooxygenase-1 (COX-1) and COX-2, and hypoxia-inducing factor-1 alpha (HIF-1 alpha) and vascular endothelial growth factor (VEGF).	Silybin	25-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	150-155
18309400-1	2008	We present a novel and facile synthesis methodology for obtaining graphitic carbon structures from Fe(II) and Co(II) gluconates.	Carbon	76-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-116
18234233-2	2008	Furthermore, we identified the contribution of ROS production system (e.g., oxidant enzymes, such as iNOS and Cox-2) to the apoptosis induction in the chorion cells, suggesting an important role of the two inducible enzymes in the induction process.	ros	47-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-115
18271519-2	2008	Previously, the COX-2 selective inhibitor nimesulide and analogs decreased aromatase expression and enzyme activity independent of COX-2 inhibition.	nimesulide	42-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-21
18225859-2	2008	The Co(II) ion in the title compound is octahedrally coordinated by six phosphonate oxygen atoms from four carboxylate phosphonate ligands.	Organophosphonates	72-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
18225859-2	2008	The Co(II) ion in the title compound is octahedrally coordinated by six phosphonate oxygen atoms from four carboxylate phosphonate ligands.	Oxygen	84-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
18225859-2	2008	The Co(II) ion in the title compound is octahedrally coordinated by six phosphonate oxygen atoms from four carboxylate phosphonate ligands.	carboxylate phosphonate	107-130	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
18237116-0	2008	Tetranuclear CoII, MnII, and CuII complexes of a novel binucleating pyrazolate ligand preorganized for the self-assembly of compact [2 x 2]-grid structures.	pyrazolate	68-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-17
18237116-3	2008	The new ligand comprises two proximate terpyridine-like binding sites and is shown to form discrete [2 x 2]-grid complexes with CoII, MnII, and CuII in a highly selective self-assembly process, even in the presence of excess metal precursor.	2,2':6',2''-Terpyridine	39-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	128-132
18237116-3	2008	The new ligand comprises two proximate terpyridine-like binding sites and is shown to form discrete [2 x 2]-grid complexes with CoII, MnII, and CuII in a highly selective self-assembly process, even in the presence of excess metal precursor.	Metals	225-230	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	128-132
21731109-7	2008	Redox potentials for structurally-related Co(II) complexes are shown to be cathodically-shifted relative to their Fe(II) analogues, making them ineffective reducing agents for substrates such as superoxide.	ammonium ferrous sulfate	114-120	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-48
21731109-7	2008	Redox potentials for structurally-related Co(II) complexes are shown to be cathodically-shifted relative to their Fe(II) analogues, making them ineffective reducing agents for substrates such as superoxide.	Superoxides	195-205	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-48
18507001-7	2008	COX-2 inhibitors, etodolac and rofecoxib, did not have an inhibitory effect on the proliferation of LM-H3 cells at low concentrations, but had significant inhibitory effect on the invasion of LM-H3 cells in in vitro experiments.	Etodolac	18-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
18507001-7	2008	COX-2 inhibitors, etodolac and rofecoxib, did not have an inhibitory effect on the proliferation of LM-H3 cells at low concentrations, but had significant inhibitory effect on the invasion of LM-H3 cells in in vitro experiments.	rofecoxib	31-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
17996418-2	2008	COX2 inhibitors may be neuroprotective in the brain by reducing prostanoid and free radical synthesis, or by directing arachidonic acid down alternate metabolic pathways.	Prostaglandins	64-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-4
17996418-2	2008	COX2 inhibitors may be neuroprotective in the brain by reducing prostanoid and free radical synthesis, or by directing arachidonic acid down alternate metabolic pathways.	Free Radicals	79-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-4
17996418-2	2008	COX2 inhibitors may be neuroprotective in the brain by reducing prostanoid and free radical synthesis, or by directing arachidonic acid down alternate metabolic pathways.	Arachidonic Acid	119-135	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-4
17996418-3	2008	The arachidonic acid shunting hypothesis proposes that COX2 inhibitors" neuroprotective effects may be mediated by increased formation of potentially beneficial eicosanoids.	Arachidonic Acid	4-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-59
17996418-3	2008	The arachidonic acid shunting hypothesis proposes that COX2 inhibitors" neuroprotective effects may be mediated by increased formation of potentially beneficial eicosanoids.	Eicosanoids	161-172	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-59
17996418-4	2008	Under conditions where COX2 activity is inhibited, arachidonic acid accumulates or is converted to eicosanoids via lipoxygenases and cytochrome P450 (CYP) epoxygenases.	Arachidonic Acid	51-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-27
17996418-4	2008	Under conditions where COX2 activity is inhibited, arachidonic acid accumulates or is converted to eicosanoids via lipoxygenases and cytochrome P450 (CYP) epoxygenases.	Eicosanoids	99-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-27
17996418-7	2008	Thus, COX2 inhibition and arachidonic acid shunting have therapeutic implications beyond the suppression of prostaglandin synthesis and free radical formation.	Prostaglandins	108-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	6-10
18157162-10	2008	The immunomodulatory effects of SR141716 were associated with increased expression of IkappaB, phosphorylated AKT (p-AKT) and decreased expression of NF-kappaB, p-IkappaB, p-ERK, COX-2 and iNOS.	Rimonabant	32-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	179-184
18167131-1	2008	Cyclooxygenase (COX) is a key enzyme in the formation of prostaglandins, and an inducible isoform of COX, COX-2, has been implicated in colorectal carcinogenesis.	Prostaglandins	57-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-111
18516356-10	2008	The older NSAIDs, such as meloxicam, with preferential COX-2 inhibition do not have good long-term evidence of reducing the incidence of serious gastrointestinal complications.	Meloxicam	26-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-60
20852730-10	2008	The number of responsive peaks also decreased slightly yet significantly when either the COX-2/PGE(2) or the NOS/nitric oxide pathway was disrupted.	Prostaglandins E	95-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-94
18437081-5	2008	The COX-2-dependent mechanism of eicosapentaenoic acid was mediated by binding of PGE3 to EP2 and EP4 receptors.	Eicosapentaenoic Acid	33-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
18437081-5	2008	The COX-2-dependent mechanism of eicosapentaenoic acid was mediated by binding of PGE3 to EP2 and EP4 receptors.	prostaglandin E3	82-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
18343721-2	2008	In non-myocardial tissue, the cyclooxygenase (COX)-2 inhibitor celecoxib has been shown to COX-independently inhibit Akt signalling.	Celecoxib	63-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-52
17763959-11	2008	Ghrelin caused a decrease in TNFalpha-induced COX-2 and IL-1beta expression in OE-19 cells.	Ghrelin	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
18255268-3	2008	However, the role of COX-2 and its main product, prostaglandin E(2) (PGE(2)), in the convulsive states is not fully established.	Dinoprostone	69-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-26
18255268-4	2008	In this study we showed that the selective COX-2 inhibitor, celecoxib (at the dose of 2mg/kg, but not at the doses of 0.2 or 20mg/kg, p.o.	Celecoxib	60-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
18255268-14	2008	These data constitute strong converging pharmacological evidence supporting a facilitatory role for the COX-2/PGE(2) pathway in the seizures induced by PTZ.	Dinoprostone	110-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
18255268-14	2008	These data constitute strong converging pharmacological evidence supporting a facilitatory role for the COX-2/PGE(2) pathway in the seizures induced by PTZ.	Pentylenetetrazole	152-155	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
18300697-5	2008	METHODS: The CADEUS study included patients treated with COX-2 inhibitors (celecoxib, rofecoxib) or traditional NSAIDs from September 2003 to August 2004.	Celecoxib	75-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-62
18060564-7	2008	Release of the platinum complexes from vitamin B12 is driven by intracellular reduction of Co(III) to Co(II) to Co(I) and subsequent adenosylation by the adenosyltransferase CobA.	Platinum	15-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-108
18172906-1	2008	OBJECTIVE: To investigate whether the cox-2 inhibitor celecoxib has antidepressant effects in bipolar disorder (BD) patients during depressive or mixed phases.	Celecoxib	54-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-43
18279804-8	2008	Selenium also suppressed the expression of COX-2 and iNOS and the endogenous IFN beta mRNA induced by poly[I:C] or LPS.	Selenium	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
18060564-7	2008	Release of the platinum complexes from vitamin B12 is driven by intracellular reduction of Co(III) to Co(II) to Co(I) and subsequent adenosylation by the adenosyltransferase CobA.	Vitamin B 12	39-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-108
18088065-5	2008	RESULTS: In vitro studies revealed robust and sustained Cox-2 protein expression, prostaglandin E(2) and alkaline phosphatase production in rat bone marrow stromal cells and osteoblasts transgenic for the hCox-2 gene.	Dinoprostone	82-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	205-211
17658686-1	2008	The extraction equilibrium of Co(II) from thiocyanate medium by CYANEX 923 (mixture of straight chain alkylated phosphine oxides) in cyclohexane was studied.	thiocyanate	42-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-36
17658686-6	2008	The applicability of the emulsion liquid membrane (ELM) process using CYANEX 923 as extractant and SPAN 80 as surfactant for the removal and the concentration of Co(II) from thiocyanate solution was investigated.	thiocyanate	174-185	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	162-168
17658686-1	2008	The extraction equilibrium of Co(II) from thiocyanate medium by CYANEX 923 (mixture of straight chain alkylated phosphine oxides) in cyclohexane was studied.	cyanex 923	64-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-36
17658686-1	2008	The extraction equilibrium of Co(II) from thiocyanate medium by CYANEX 923 (mixture of straight chain alkylated phosphine oxides) in cyclohexane was studied.	phosphine oxides	112-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-36
17658686-1	2008	The extraction equilibrium of Co(II) from thiocyanate medium by CYANEX 923 (mixture of straight chain alkylated phosphine oxides) in cyclohexane was studied.	Cyclohexane	133-144	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-36
17658686-3	2008	The stripping percentage of Co(II) with sulphuric acid from the loaded CYANEX 923 was found to increase with the increase in acid concentration.	sulfuric acid	40-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-34
17658686-3	2008	The stripping percentage of Co(II) with sulphuric acid from the loaded CYANEX 923 was found to increase with the increase in acid concentration.	cyanex	71-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-34
17658686-4	2008	The extraction of Co(II) from aqueous thiocyanate medium into emulsion liquid membrane using CYANEX 923 extractant was also studied.	thiocyanate	38-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-24
17658686-4	2008	The extraction of Co(II) from aqueous thiocyanate medium into emulsion liquid membrane using CYANEX 923 extractant was also studied.	cyanex 923	93-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-24
18089846-11	2008	Our findings indicate both COX-2-dependent and -independent mechanisms attributable to celecoxib and support its utility in the management of prostate cancer.	Celecoxib	87-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-32
18388472-11	2008	Gamma-irradiation increased cyclooxygenase-1 (COX-2) expression, whereas the combination with genistein and gamma-irradiation almost completely prevented irradiation-induced COX-2 expression and PGE2 production.	Genistein	94-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	174-179
18287347-6	2008	Oleanolic acid induced prostaglandin I2 (PGI2) release by human coronary SMC, an effect that was prevented by celecoxib (a specific inhibitor of Cox-2).	Oleanolic Acid	0-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-150
18287347-6	2008	Oleanolic acid induced prostaglandin I2 (PGI2) release by human coronary SMC, an effect that was prevented by celecoxib (a specific inhibitor of Cox-2).	Epoprostenol	23-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-150
18287347-6	2008	Oleanolic acid induced prostaglandin I2 (PGI2) release by human coronary SMC, an effect that was prevented by celecoxib (a specific inhibitor of Cox-2).	Epoprostenol	41-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-150
18287347-6	2008	Oleanolic acid induced prostaglandin I2 (PGI2) release by human coronary SMC, an effect that was prevented by celecoxib (a specific inhibitor of Cox-2).	Celecoxib	110-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-150
18287347-7	2008	The increased PGI2 was time-and dose-dependent and was associated to the up-regulation of Cox-2.	Epoprostenol	14-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-95
18287347-9	2008	Erythrodiol but not hydroxytyrosol upregulated Cox-2 expression and induced PGI2 synthesis.	erythrodiol	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
18287347-11	2008	SB203580 (p38MAPK inhibitor) and U0126 (MAPK kinase1/2 inhibitor) abrogated the upregulation of Cox-2 and PGI2 release induced by oleanolic acid.	SB 203580	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-101
18287347-11	2008	SB203580 (p38MAPK inhibitor) and U0126 (MAPK kinase1/2 inhibitor) abrogated the upregulation of Cox-2 and PGI2 release induced by oleanolic acid.	U 0126	33-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-101
18287347-11	2008	SB203580 (p38MAPK inhibitor) and U0126 (MAPK kinase1/2 inhibitor) abrogated the upregulation of Cox-2 and PGI2 release induced by oleanolic acid.	Oleanolic Acid	130-144	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-101
18247511-2	2008	CoII ions seem to cause only a moderate perturbation of the reaction mechanism, causing a fast conversion of the cyclohexyl hydroperoxide via a redox cycle, rather than via abstraction of the alphaH-atom by chain carrying peroxyl radicals.	Cyclohexyl hydroperoxide	113-137	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-4
18287347-13	2008	The induction of Cox-2 was preceded by an early activation of cAMP regulatory element-binding protein, a key transcription factor involved in Cox-2 transcriptional upregulation.	Cyclic AMP	62-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22
18287347-13	2008	The induction of Cox-2 was preceded by an early activation of cAMP regulatory element-binding protein, a key transcription factor involved in Cox-2 transcriptional upregulation.	Cyclic AMP	62-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	142-147
18287347-14	2008	Therefore, oleanolic acid contributes to vascular homeostasis by inducing PGI2 release in a Cox-2-dependent manner.	Oleanolic Acid	11-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-97
18287347-14	2008	Therefore, oleanolic acid contributes to vascular homeostasis by inducing PGI2 release in a Cox-2-dependent manner.	Epoprostenol	74-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-97
18247511-2	2008	CoII ions seem to cause only a moderate perturbation of the reaction mechanism, causing a fast conversion of the cyclohexyl hydroperoxide via a redox cycle, rather than via abstraction of the alphaH-atom by chain carrying peroxyl radicals.	alphah	192-198	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-4
18247511-2	2008	CoII ions seem to cause only a moderate perturbation of the reaction mechanism, causing a fast conversion of the cyclohexyl hydroperoxide via a redox cycle, rather than via abstraction of the alphaH-atom by chain carrying peroxyl radicals.	perhydroxyl radical	222-238	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-4
18247511-3	2008	Nevertheless, both the radical propagation and the CoII-induced decomposition of the hydroperoxide cause the formation of cyclohexoxy radicals that are partially transformed to 6-hydroxyhexanoic acid, the major primary byproduct for these systems.	Hydrogen Peroxide	85-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-55
18247511-3	2008	Nevertheless, both the radical propagation and the CoII-induced decomposition of the hydroperoxide cause the formation of cyclohexoxy radicals that are partially transformed to 6-hydroxyhexanoic acid, the major primary byproduct for these systems.	cyclohexoxy radicals	122-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-55
18247511-3	2008	Nevertheless, both the radical propagation and the CoII-induced decomposition of the hydroperoxide cause the formation of cyclohexoxy radicals that are partially transformed to 6-hydroxyhexanoic acid, the major primary byproduct for these systems.	6-hydroxyhexanoic acid	177-199	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-55
18247511-4	2008	However, during the CoII-catalyzed reaction, the concentration of cyclohexanone increases much faster than that of the hydroperoxide, causing the ketone to take over the role of dominant byproduct source.	cyclohexanone	66-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-24
18247511-4	2008	However, during the CoII-catalyzed reaction, the concentration of cyclohexanone increases much faster than that of the hydroperoxide, causing the ketone to take over the role of dominant byproduct source.	Hydrogen Peroxide	119-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-24
18247511-4	2008	However, during the CoII-catalyzed reaction, the concentration of cyclohexanone increases much faster than that of the hydroperoxide, causing the ketone to take over the role of dominant byproduct source.	Ketones	146-152	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-24
18239831-0	2008	Assembling metals (Co II and Mn II) with pyridylcarboxylates in the presence of azide: synthesis, structural aspects and magnetic behavior of three coordination polymers.	pyridylcarboxylates	41-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-34
18166012-8	2008	The cyclic voltammograms of the [Cp*Co(dithiolene)] complexes performed in CH 2Cl 2 show reversible Co (III) to Co (II) reduction but irreversible oxidation waves.	cp*co(dithiolene)	33-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-119
18166012-8	2008	The cyclic voltammograms of the [Cp*Co(dithiolene)] complexes performed in CH 2Cl 2 show reversible Co (III) to Co (II) reduction but irreversible oxidation waves.	2cl 2	78-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-119
18166012-8	2008	The cyclic voltammograms of the [Cp*Co(dithiolene)] complexes performed in CH 2Cl 2 show reversible Co (III) to Co (II) reduction but irreversible oxidation waves.	co (iii)	100-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-119
18166012-9	2008	The large potential difference between the two reduction waves of the bimetallic complex 1 (269 mV) indicates a stable mixed-valence Co (III)-Co (II) state for the reduced [Cp*Co(btt)CoCp*] (-) anion.	co (iii)	133-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	142-149
18166012-9	2008	The large potential difference between the two reduction waves of the bimetallic complex 1 (269 mV) indicates a stable mixed-valence Co (III)-Co (II) state for the reduced [Cp*Co(btt)CoCp*] (-) anion.	[cp*co(btt)cocp*	172-188	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	142-149
18166012-9	2008	The large potential difference between the two reduction waves of the bimetallic complex 1 (269 mV) indicates a stable mixed-valence Co (III)-Co (II) state for the reduced [Cp*Co(btt)CoCp*] (-) anion.	Anions	190-199	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	142-149
18023187-1	2008	A group of 1-(aminosulfonylphenyl and methylsulfonylphenyl)-2-(pyridyl)acetylene regioisomers were designed such that a COX-2 SO2NH2 pharmacophore was located at the para-position of the phenyl ring, or a SO2Me pharmacophore was placed at the ortho-, meta- or para-position of the phenyl ring, on an acetylene template (scaffold).	1-(aminosulfonylphenyl and methylsulfonylphenyl)-2-(pyridyl)acetylene	11-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-125
18023187-1	2008	A group of 1-(aminosulfonylphenyl and methylsulfonylphenyl)-2-(pyridyl)acetylene regioisomers were designed such that a COX-2 SO2NH2 pharmacophore was located at the para-position of the phenyl ring, or a SO2Me pharmacophore was placed at the ortho-, meta- or para-position of the phenyl ring, on an acetylene template (scaffold).	so2nh2	126-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-125
18023187-1	2008	A group of 1-(aminosulfonylphenyl and methylsulfonylphenyl)-2-(pyridyl)acetylene regioisomers were designed such that a COX-2 SO2NH2 pharmacophore was located at the para-position of the phenyl ring, or a SO2Me pharmacophore was placed at the ortho-, meta- or para-position of the phenyl ring, on an acetylene template (scaffold).	so2me	205-210	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-125
18023187-1	2008	A group of 1-(aminosulfonylphenyl and methylsulfonylphenyl)-2-(pyridyl)acetylene regioisomers were designed such that a COX-2 SO2NH2 pharmacophore was located at the para-position of the phenyl ring, or a SO2Me pharmacophore was placed at the ortho-, meta- or para-position of the phenyl ring, on an acetylene template (scaffold).	Acetylene	71-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-125
18023187-4	2008	Structure-activity relationship (SAR) data (IC50 values) acquired by determination of the in vitro ability of the title compounds to inhibit the COX-1 and COX-2 isozymes showed that the position of the COX-2 SO2NH2 or SO2Me pharmacophore on the phenyl ring, and the point of attachment of the pyridyl ring to the acetylene linker, were either individual, or collective, determinants of COX-2 inhibitory potency and selectivity.	so2nh2	208-214	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	155-160
18023187-4	2008	Structure-activity relationship (SAR) data (IC50 values) acquired by determination of the in vitro ability of the title compounds to inhibit the COX-1 and COX-2 isozymes showed that the position of the COX-2 SO2NH2 or SO2Me pharmacophore on the phenyl ring, and the point of attachment of the pyridyl ring to the acetylene linker, were either individual, or collective, determinants of COX-2 inhibitory potency and selectivity.	so2nh2	208-214	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	202-207
18023187-4	2008	Structure-activity relationship (SAR) data (IC50 values) acquired by determination of the in vitro ability of the title compounds to inhibit the COX-1 and COX-2 isozymes showed that the position of the COX-2 SO2NH2 or SO2Me pharmacophore on the phenyl ring, and the point of attachment of the pyridyl ring to the acetylene linker, were either individual, or collective, determinants of COX-2 inhibitory potency and selectivity.	so2nh2	208-214	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	202-207
18023187-4	2008	Structure-activity relationship (SAR) data (IC50 values) acquired by determination of the in vitro ability of the title compounds to inhibit the COX-1 and COX-2 isozymes showed that the position of the COX-2 SO2NH2 or SO2Me pharmacophore on the phenyl ring, and the point of attachment of the pyridyl ring to the acetylene linker, were either individual, or collective, determinants of COX-2 inhibitory potency and selectivity.	so2me	218-223	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	155-160
18023187-4	2008	Structure-activity relationship (SAR) data (IC50 values) acquired by determination of the in vitro ability of the title compounds to inhibit the COX-1 and COX-2 isozymes showed that the position of the COX-2 SO2NH2 or SO2Me pharmacophore on the phenyl ring, and the point of attachment of the pyridyl ring to the acetylene linker, were either individual, or collective, determinants of COX-2 inhibitory potency and selectivity.	so2me	218-223	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	202-207
18023187-4	2008	Structure-activity relationship (SAR) data (IC50 values) acquired by determination of the in vitro ability of the title compounds to inhibit the COX-1 and COX-2 isozymes showed that the position of the COX-2 SO2NH2 or SO2Me pharmacophore on the phenyl ring, and the point of attachment of the pyridyl ring to the acetylene linker, were either individual, or collective, determinants of COX-2 inhibitory potency and selectivity.	so2me	218-223	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	202-207
18023187-4	2008	Structure-activity relationship (SAR) data (IC50 values) acquired by determination of the in vitro ability of the title compounds to inhibit the COX-1 and COX-2 isozymes showed that the position of the COX-2 SO2NH2 or SO2Me pharmacophore on the phenyl ring, and the point of attachment of the pyridyl ring to the acetylene linker, were either individual, or collective, determinants of COX-2 inhibitory potency and selectivity.	Acetylene	313-322	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	155-160
18023187-4	2008	Structure-activity relationship (SAR) data (IC50 values) acquired by determination of the in vitro ability of the title compounds to inhibit the COX-1 and COX-2 isozymes showed that the position of the COX-2 SO2NH2 or SO2Me pharmacophore on the phenyl ring, and the point of attachment of the pyridyl ring to the acetylene linker, were either individual, or collective, determinants of COX-2 inhibitory potency and selectivity.	Acetylene	313-322	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	202-207
18023187-4	2008	Structure-activity relationship (SAR) data (IC50 values) acquired by determination of the in vitro ability of the title compounds to inhibit the COX-1 and COX-2 isozymes showed that the position of the COX-2 SO2NH2 or SO2Me pharmacophore on the phenyl ring, and the point of attachment of the pyridyl ring to the acetylene linker, were either individual, or collective, determinants of COX-2 inhibitory potency and selectivity.	Acetylene	313-322	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	202-207
17566643-2	2008	The modified silica gel was used for sorption of Cu(II), Ni(II) and Co(II) in aqueous solution.	Silica Gel	13-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-74
17566643-5	2008	The sorption of metal ions onto modified silica gel correlated well with the Langmuir type adsorption isotherm and adsorption capacities were found to be 0.012, 0.014 and 0.018 mmol g(-1) for Cu(II), Ni(II) and Co(II) metal ions, respectively.	Metals	16-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	211-217
17566643-5	2008	The sorption of metal ions onto modified silica gel correlated well with the Langmuir type adsorption isotherm and adsorption capacities were found to be 0.012, 0.014 and 0.018 mmol g(-1) for Cu(II), Ni(II) and Co(II) metal ions, respectively.	Silica Gel	41-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	211-217
17574332-0	2008	Wet oxidative method for removal of 2,4,6-trichlorophenol in water using Fe(III), Co(II), Ni(II) supported MCM41 catalysts.	2,4,6-trichlorophenol	36-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-88
17574332-0	2008	Wet oxidative method for removal of 2,4,6-trichlorophenol in water using Fe(III), Co(II), Ni(II) supported MCM41 catalysts.	Water	61-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-88
17574332-2	2008	In the present work, Fe(III), Co(II) and Ni(II) incorporated MCM41 mesoporous solids were used as catalysts for oxidation of 2,4,6-trichlorophenol in water with or without the oxidant, H(2)O(2).	2,4,6-trichlorophenol	125-146	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-36
17574332-2	2008	In the present work, Fe(III), Co(II) and Ni(II) incorporated MCM41 mesoporous solids were used as catalysts for oxidation of 2,4,6-trichlorophenol in water with or without the oxidant, H(2)O(2).	Water	150-155	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-36
17574332-6	2008	The conversion achieved with Fe(III), Co(II) and Ni(II) incorporated MCM41 in 5h is respectively 59.4, 50.0 and 65.6% with 2,4,6-TCP:H(2)O(2) molar ratio of 1:1, and 60.2, 60.9 and 68.8% in absence of H(2)O(2).	2,4,6-trichlorophenol	123-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-44
17574332-6	2008	The conversion achieved with Fe(III), Co(II) and Ni(II) incorporated MCM41 in 5h is respectively 59.4, 50.0 and 65.6% with 2,4,6-TCP:H(2)O(2) molar ratio of 1:1, and 60.2, 60.9 and 68.8% in absence of H(2)O(2).	h(2)	133-137	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-44
17574332-6	2008	The conversion achieved with Fe(III), Co(II) and Ni(II) incorporated MCM41 in 5h is respectively 59.4, 50.0 and 65.6% with 2,4,6-TCP:H(2)O(2) molar ratio of 1:1, and 60.2, 60.9 and 68.8% in absence of H(2)O(2).	Water	133-138	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-44
17574332-8	2008	The results show that introduction of Fe(III), Co(II) and Ni(II) into MCM-41 through impregnation produces very effective catalysts for wet oxidation of 2,4,6-trichlorophenol.	ferric sulfate	38-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-76
17574332-8	2008	The results show that introduction of Fe(III), Co(II) and Ni(II) into MCM-41 through impregnation produces very effective catalysts for wet oxidation of 2,4,6-trichlorophenol.	2,4,6-trichlorophenol	153-174	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-76
18029351-10	2008	Furthermore, COX-2 induction or expression markedly enhanced iNOS-induced cPLA(2)alpha S-nitrosylation and activation, leading to 9-, 23-, and 20-fold increase of AA release and 100-, 38-, and 88-fold of PGE(2) production in A549, SG231, and HEK293 cells, respectively, whereas COX-2 alone leads to less than 2-fold change.	Prostaglandins E	204-207	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
18029351-11	2008	These results indicate that COX-2 has the ability to enhance iNOS-induced cPLA(2)alpha S-nitrosylation and that maximal PG synthesis is achieved by the synergistic interaction among iNOS, cPLA(2)alpha, and COX-2.	pg	120-122	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	206-211
18179273-1	2008	We report on the influence of a series of transition-metal-substituted Wells-Dawson (P2W17MnO62(12-n)-; M = WVI, FeII, CoII, RuII) and Keggin (PW12O40(3-) and PCoW11O39(5-) anions on the oxygen reduction reaction (ORR) at Au, Pd, and Pt.	transition-	42-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-123
18179273-1	2008	We report on the influence of a series of transition-metal-substituted Wells-Dawson (P2W17MnO62(12-n)-; M = WVI, FeII, CoII, RuII) and Keggin (PW12O40(3-) and PCoW11O39(5-) anions on the oxygen reduction reaction (ORR) at Au, Pd, and Pt.	Metals	53-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-123
17709599-6	2008	Inhibition of cyclooxygenase (Cox)-2 with NS-398 was associated with reductions in Cox-2 (2-fold) and IL-6 (1.3-fold) mRNA transcripts, and in IL-8 and PGE-2 chemokine secretion.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	42-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
18042663-8	2008	The enhanced PGE(2) production caused by CP55,940 was abrogated by cotreatment with either SR141716A or NS398, illustrating that the cannabinoid action on prostaglandin production in fetal membranes is mediated by CB1 agonism and COX-2.	Dinoprostone	13-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	230-235
18042663-8	2008	The enhanced PGE(2) production caused by CP55,940 was abrogated by cotreatment with either SR141716A or NS398, illustrating that the cannabinoid action on prostaglandin production in fetal membranes is mediated by CB1 agonism and COX-2.	Rimonabant	91-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	230-235
18042663-8	2008	The enhanced PGE(2) production caused by CP55,940 was abrogated by cotreatment with either SR141716A or NS398, illustrating that the cannabinoid action on prostaglandin production in fetal membranes is mediated by CB1 agonism and COX-2.	Cannabinoids	133-144	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	230-235
18042663-9	2008	Data from Western blotting show that cannabinoid treatment results in the upregulation of COX-2 expression.	Cannabinoids	37-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-95
18239831-0	2008	Assembling metals (Co II and Mn II) with pyridylcarboxylates in the presence of azide: synthesis, structural aspects and magnetic behavior of three coordination polymers.	Azides	80-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-34
18239831-0	2008	Assembling metals (Co II and Mn II) with pyridylcarboxylates in the presence of azide: synthesis, structural aspects and magnetic behavior of three coordination polymers.	Polymers	161-169	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-34
17999062-0	2008	Dup-697, a specific COX-2 inhibitor, suppresses growth and induces apoptosis on K562 leukemia cells by cell-cycle arrest and caspase-8 activation.	DuP 697	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-25
17721551-2	2008	They are COX-2 derived oxidation products of the endocannabinoid/endovanniloid anandamide.	Endocannabinoids	49-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	9-14
17721551-2	2008	They are COX-2 derived oxidation products of the endocannabinoid/endovanniloid anandamide.	endovanniloid anandamide	65-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	9-14
17884974-3	2008	The fact that acetaminophen acts functionally as a selective COX-2 inhibitor led us to investigate the hypothesis of whether it works via preferential COX-2 blockade.	Acetaminophen	14-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-66
17884974-6	2008	In vitro, acetaminophen elicited a 4.4-fold selectivity toward COX-2 inhibition (IC(50)=113.7 micromol/L for COX-1; IC(50)=25.8 micromol/L for COX-2).	Acetaminophen	10-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-68
17884974-6	2008	In vitro, acetaminophen elicited a 4.4-fold selectivity toward COX-2 inhibition (IC(50)=113.7 micromol/L for COX-1; IC(50)=25.8 micromol/L for COX-2).	Acetaminophen	10-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	143-148
17884974-8	2008	Acetaminophen plasma concentrations remained above the in vitro IC(50) for COX-2 for at least 5 h postadministration.	Acetaminophen	0-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
17884974-9	2008	Ex vivo IC(50) values (COX-1: 105.2 micromol/L; COX-2: 26.3 micromol/L) of acetaminophen compared favorably with its in vitro IC(50) values.	Acetaminophen	75-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-53
17884974-10	2008	In contrast to previous concepts, acetaminophen inhibited COX-2 by more than 80%, i.e., to a degree comparable to nonsteroidal antiinflammatory drugs (NSAIDs) and selective COX-2 inhibitors.	Acetaminophen	34-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
17884974-13	2008	In view of its substantial COX-2 inhibition, recently defined cardiovascular warnings for use of COX-2 inhibitors should also be considered for acetaminophen.	Acetaminophen	144-157	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
18156149-0	2008	LPS-activated monocytes suppress T-cell immune responses and induce FOXP3+ T cells through a COX-2-PGE2-dependent mechanism.	Dinoprostone	99-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-98
18230053-0	2008	Celecoxib analogs that lack COX-2 inhibitory function: preclinical development of novel anticancer drugs.	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
18230053-1	2008	Celecoxib is an NSAID that was developed as a selective inhibitor of COX-2 and approved by the FDA for the treatment of various forms of arthritis and the management of acute or chronic pain.	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-74
18230053-4	2008	Intriguingly, the two pharmacologic effects, inhibition of COX-2 and suppression of tumor growth, were found to reside in different structural aspects of the celecoxib molecule and, therefore, could be separated.	Celecoxib	158-167	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-64
18230053-5	2008	This dualism enabled the synthesis of close structural analogs of celecoxib that exhibited increased antitumor potency in the absence of COX-2 inhibition.	Celecoxib	66-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-142
18230053-7	2008	In this review, the authors present the status of preclinical development of anticancer analogs of celecoxib that are COX-2 inactive, with an emphasis on 2,5-dimethyl-celecoxib (DMC) and OSU-03012.	Celecoxib	99-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-123
17918156-1	2008	Recent studies have shown that inhibition of cyclooxygenases (e.g. COX-2) exerts antitumorigenic effects on hepatocellular carcinomas (HCCs), which are to a significant extent due to the abrogation of PGE(2) synthesis.	Prostaglandins E	201-204	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-72
18156149-3	2008	Here, we demonstrate that stimulation of monocytes with LPS leads to suppression of T-cell immune responses by a COX-2-PGE(2)-dependent mechanism that is reversible with COX-2 inhibitors as well as PGE(2)-neutralizing antibody and cAMP antagonist.	Dinoprostone	119-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-118
18156149-3	2008	Here, we demonstrate that stimulation of monocytes with LPS leads to suppression of T-cell immune responses by a COX-2-PGE(2)-dependent mechanism that is reversible with COX-2 inhibitors as well as PGE(2)-neutralizing antibody and cAMP antagonist.	Dinoprostone	119-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	170-175
18156149-3	2008	Here, we demonstrate that stimulation of monocytes with LPS leads to suppression of T-cell immune responses by a COX-2-PGE(2)-dependent mechanism that is reversible with COX-2 inhibitors as well as PGE(2)-neutralizing antibody and cAMP antagonist.	Cyclic AMP	231-235	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-118
17531526-1	2008	A flow-through optical fibre chemical sensor for the determination of Co(II) at trace level using immobilised 2-(4-pyridylazo)resorcinol (PAR) as the reagent phase is proposed.	2-(4-pyridylazo)resorcinol	110-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-76
18083528-4	2008	The dissociation of complexes of the form [Co(II) (flavonoid glucuronide - H) (4,7-diphenyl-1,10-phenanthroline)(2)]+ allowed identification of the products and differentiation of isomers.	flavonoid glucuronide - h)	51-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-49
18083528-4	2008	The dissociation of complexes of the form [Co(II) (flavonoid glucuronide - H) (4,7-diphenyl-1,10-phenanthroline)(2)]+ allowed identification of the products and differentiation of isomers.	bathophenanthroline	79-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-49
18209033-6	2008	Specifically in response to TNF-alpha, TGF-beta, and LPS, protein expression of cyclooxygenase (COX)-2 and downstream PGE synthase was up-regulated with coordinate kinetics, whereas COX-1 and PGIS were constitutively expressed.	Prostaglandins I	192-196	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-102
18209033-9	2008	Furthermore, the up-regulation of PGE(2) and PGI(2) production was markedly down-regulated by indomethacin and a selective COX-2 inhibitor.	Prostaglandins E	34-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-128
18209033-9	2008	Furthermore, the up-regulation of PGE(2) and PGI(2) production was markedly down-regulated by indomethacin and a selective COX-2 inhibitor.	Epoprostenol	45-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-128
18209033-9	2008	Furthermore, the up-regulation of PGE(2) and PGI(2) production was markedly down-regulated by indomethacin and a selective COX-2 inhibitor.	Indomethacin	94-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-128
17531526-1	2008	A flow-through optical fibre chemical sensor for the determination of Co(II) at trace level using immobilised 2-(4-pyridylazo)resorcinol (PAR) as the reagent phase is proposed.	paratose	138-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-76
17531526-6	2008	The response towards Co(II) was also reversible using acidified KCl as the regenerating solution.	Potassium Chloride	64-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-27
17544579-1	2008	Separation with solvent extraction of Cu(II), Co(II) and Ni(II) from aqueous solution using N,N"-bis-(salicylaldehydene)-1,4-bis-(p-aminophenoxy)butane (H(2)L) as the new extractant has been studied.	h(2)l)	153-159	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-63
18237405-2	2008	Herein, we tested that the hypothesis that NTHi induces the expression of cyclooxygenase (COX)-2 and prostaglandin E2 (PGE2) via activation of p38 mitogen-activated protein kinase (MAPK) and nuclear factor (NF)-kappa B in pulmonary alveolar epithelial cells.	nthi	43-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-96
18237405-8	2008	The enhanced expression of PGE2 by NTHi infection was significantly decreased by pre-treatment of COX-2 specific inhibitor, but not by COX-1 inhibitor.	Dinoprostone	27-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-103
18237405-6	2008	In addition, the role of p38 MAPK and NF-kappa B on the NTHi-induced COX-2 and PGE2 expression was investigated by using their specific chemical inhibitors.	nthi	56-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-74
17920040-1	2008	To uncover the full spectrum of its pharmacological activities, the selective COX-2 inhibitor celecoxib is routinely being used at concentrations of up to 100 microM in cell culture.	Celecoxib	94-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-83
17920040-3	2008	Here, we report a COX-2-independent effect of celecoxib that might have profound consequences for the interpretation of previous results obtained at elevated concentrations of this drug in vitro.	Celecoxib	46-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-23
17920040-6	2008	These effects were not achieved by other coxibs (rofecoxib, valdecoxib) or traditional NSAIDs (indomethacin, flurbiprofen), but were mimicked by the COX-2-inactive celecoxib analog, 2,5-dimethyl-celecoxib (DMC), indicating COX-2 independence.	Celecoxib	164-173	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	149-154
17920040-6	2008	These effects were not achieved by other coxibs (rofecoxib, valdecoxib) or traditional NSAIDs (indomethacin, flurbiprofen), but were mimicked by the COX-2-inactive celecoxib analog, 2,5-dimethyl-celecoxib (DMC), indicating COX-2 independence.	Celecoxib	164-173	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	223-228
17920040-6	2008	These effects were not achieved by other coxibs (rofecoxib, valdecoxib) or traditional NSAIDs (indomethacin, flurbiprofen), but were mimicked by the COX-2-inactive celecoxib analog, 2,5-dimethyl-celecoxib (DMC), indicating COX-2 independence.	2,5-dimethylcelecoxib	182-204	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	149-154
17920040-6	2008	These effects were not achieved by other coxibs (rofecoxib, valdecoxib) or traditional NSAIDs (indomethacin, flurbiprofen), but were mimicked by the COX-2-inactive celecoxib analog, 2,5-dimethyl-celecoxib (DMC), indicating COX-2 independence.	2,5-dimethylcelecoxib	206-209	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	149-154
17920040-7	2008	Considering the obvious impact of blocked translation on cellular function, we provide evidence that this severe inhibition of protein synthesis might suffice to explain some of the previously reported COX-2-independent effects of celecoxib, such as the down-regulation of the essential cell cycle regulatory protein cyclin D, which is a short-lived protein that rapidly disappears in response to the inhibition of protein synthesis.	Celecoxib	231-240	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	202-207
17920563-6	2008	Our results showed that cinnamaldehyde suppressed the activation of NFkappaB and IRF3 induced by LPS, a TLR4 agonist, leading to the decreased expression of target genes such as COX-2 and IFNbeta in macrophages (RAW264.7).	cinnamaldehyde	24-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	178-183
18097493-4	2008	On the other hand, the reaction of Co(O2CMe)2.4H2O with 1,4-bis[o-(pyrazine-2-carboxamidophenyl)]-1,5-dithiopentane (H2) (-CH2CH2CH2- spacer between the two pyrazine amide tridentate coordination units) in air affords a cobalt(II) complex [CoII(L2)].MeOH (1b.MeOH) (S = 1/2); its structurally characterized variety has the composition 1b.C6H6.	co(o2cme)2.4h2o	35-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	240-244
17993463-8	2008	Correspondingly, both PGDM and 2,3-dinor-11beta-PGF(2alpha) were suppressed by inhibition of COX-1 and COX-2, but not by selective inhibition of COX-2 in humans.	9-hydroxy-11,15-dioxo-2,3,18,19-tetranorprost-5-ene-1,20-dioic acid	22-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-108
18097493-4	2008	On the other hand, the reaction of Co(O2CMe)2.4H2O with 1,4-bis[o-(pyrazine-2-carboxamidophenyl)]-1,5-dithiopentane (H2) (-CH2CH2CH2- spacer between the two pyrazine amide tridentate coordination units) in air affords a cobalt(II) complex [CoII(L2)].MeOH (1b.MeOH) (S = 1/2); its structurally characterized variety has the composition 1b.C6H6.	1,4-bis[o-(pyrazine-2-carboxamidophenyl)]-1,5-dithiopentane (h2) (-ch2ch2ch2- spacer	56-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	240-244
18097493-11	2008	Cyclic voltammetry experiments in MeCN-CH2Cl2 reveal facile metal-centred reversible-to-quasireversible CoIV-CoIII (or a ligand-centred redox process; 2a), CoIII-CoII (1a, 1b.MeOH, 2a, 2b and 3), CoII-CoI (1a, 1b.MeOH, 2aand 2b), and CoI-Co0 (1a, 1b.MeOH and 2b) redox processes.	acetonitrile	34-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-113
18097493-11	2008	Cyclic voltammetry experiments in MeCN-CH2Cl2 reveal facile metal-centred reversible-to-quasireversible CoIV-CoIII (or a ligand-centred redox process; 2a), CoIII-CoII (1a, 1b.MeOH, 2a, 2b and 3), CoII-CoI (1a, 1b.MeOH, 2aand 2b), and CoI-Co0 (1a, 1b.MeOH and 2b) redox processes.	acetonitrile	34-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	156-160
18097493-11	2008	Cyclic voltammetry experiments in MeCN-CH2Cl2 reveal facile metal-centred reversible-to-quasireversible CoIV-CoIII (or a ligand-centred redox process; 2a), CoIII-CoII (1a, 1b.MeOH, 2a, 2b and 3), CoII-CoI (1a, 1b.MeOH, 2aand 2b), and CoI-Co0 (1a, 1b.MeOH and 2b) redox processes.	Methylene Chloride	39-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-113
18097493-11	2008	Cyclic voltammetry experiments in MeCN-CH2Cl2 reveal facile metal-centred reversible-to-quasireversible CoIV-CoIII (or a ligand-centred redox process; 2a), CoIII-CoII (1a, 1b.MeOH, 2a, 2b and 3), CoII-CoI (1a, 1b.MeOH, 2aand 2b), and CoI-Co0 (1a, 1b.MeOH and 2b) redox processes.	Methylene Chloride	39-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	156-160
18097493-11	2008	Cyclic voltammetry experiments in MeCN-CH2Cl2 reveal facile metal-centred reversible-to-quasireversible CoIV-CoIII (or a ligand-centred redox process; 2a), CoIII-CoII (1a, 1b.MeOH, 2a, 2b and 3), CoII-CoI (1a, 1b.MeOH, 2aand 2b), and CoI-Co0 (1a, 1b.MeOH and 2b) redox processes.	Metals	60-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-113
18097493-11	2008	Cyclic voltammetry experiments in MeCN-CH2Cl2 reveal facile metal-centred reversible-to-quasireversible CoIV-CoIII (or a ligand-centred redox process; 2a), CoIII-CoII (1a, 1b.MeOH, 2a, 2b and 3), CoII-CoI (1a, 1b.MeOH, 2aand 2b), and CoI-Co0 (1a, 1b.MeOH and 2b) redox processes.	Metals	60-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	156-160
18097493-11	2008	Cyclic voltammetry experiments in MeCN-CH2Cl2 reveal facile metal-centred reversible-to-quasireversible CoIV-CoIII (or a ligand-centred redox process; 2a), CoIII-CoII (1a, 1b.MeOH, 2a, 2b and 3), CoII-CoI (1a, 1b.MeOH, 2aand 2b), and CoI-Co0 (1a, 1b.MeOH and 2b) redox processes.	Methanol	175-179	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-113
18097493-11	2008	Cyclic voltammetry experiments in MeCN-CH2Cl2 reveal facile metal-centred reversible-to-quasireversible CoIV-CoIII (or a ligand-centred redox process; 2a), CoIII-CoII (1a, 1b.MeOH, 2a, 2b and 3), CoII-CoI (1a, 1b.MeOH, 2aand 2b), and CoI-Co0 (1a, 1b.MeOH and 2b) redox processes.	Methanol	175-179	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	156-160
18097493-11	2008	Cyclic voltammetry experiments in MeCN-CH2Cl2 reveal facile metal-centred reversible-to-quasireversible CoIV-CoIII (or a ligand-centred redox process; 2a), CoIII-CoII (1a, 1b.MeOH, 2a, 2b and 3), CoII-CoI (1a, 1b.MeOH, 2aand 2b), and CoI-Co0 (1a, 1b.MeOH and 2b) redox processes.	Methanol	213-217	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-113
18097493-11	2008	Cyclic voltammetry experiments in MeCN-CH2Cl2 reveal facile metal-centred reversible-to-quasireversible CoIV-CoIII (or a ligand-centred redox process; 2a), CoIII-CoII (1a, 1b.MeOH, 2a, 2b and 3), CoII-CoI (1a, 1b.MeOH, 2aand 2b), and CoI-Co0 (1a, 1b.MeOH and 2b) redox processes.	Methanol	213-217	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	156-160
18097493-11	2008	Cyclic voltammetry experiments in MeCN-CH2Cl2 reveal facile metal-centred reversible-to-quasireversible CoIV-CoIII (or a ligand-centred redox process; 2a), CoIII-CoII (1a, 1b.MeOH, 2a, 2b and 3), CoII-CoI (1a, 1b.MeOH, 2aand 2b), and CoI-Co0 (1a, 1b.MeOH and 2b) redox processes.	Methanol	213-217	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-113
18097493-11	2008	Cyclic voltammetry experiments in MeCN-CH2Cl2 reveal facile metal-centred reversible-to-quasireversible CoIV-CoIII (or a ligand-centred redox process; 2a), CoIII-CoII (1a, 1b.MeOH, 2a, 2b and 3), CoII-CoI (1a, 1b.MeOH, 2aand 2b), and CoI-Co0 (1a, 1b.MeOH and 2b) redox processes.	Methanol	213-217	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	156-160
18072726-1	2008	A series of 1,5-diarylpyrazoles with a substituted benzenesulfonamide moiety was synthesized and evaluated for cyclooxygenase (COX-1/COX-2) inhibitory activities.	1,5-diarylpyrazoles	12-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	133-138
18076158-5	2008	Iron and cobalt complexation reactions are complicated by redox processes, which lead to mixed-oxidation-state Co(II)/Co(III) systems when starting with Co(II) salts, and reduction of Fe(III) to Fe(II) when starting with Fe(III).	Iron	0-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	111-117
18076158-5	2008	Iron and cobalt complexation reactions are complicated by redox processes, which lead to mixed-oxidation-state Co(II)/Co(III) systems when starting with Co(II) salts, and reduction of Fe(III) to Fe(II) when starting with Fe(III).	Iron	0-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	153-159
18076158-5	2008	Iron and cobalt complexation reactions are complicated by redox processes, which lead to mixed-oxidation-state Co(II)/Co(III) systems when starting with Co(II) salts, and reduction of Fe(III) to Fe(II) when starting with Fe(III).	Cobalt	9-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	111-117
18076158-5	2008	Iron and cobalt complexation reactions are complicated by redox processes, which lead to mixed-oxidation-state Co(II)/Co(III) systems when starting with Co(II) salts, and reduction of Fe(III) to Fe(II) when starting with Fe(III).	Cobalt	9-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	153-159
18399232-0	2008	Theoretical and electrochemical studies on organometallic symmetrical schiff base complexes of Zn(II), Cu(II), Ni(II) and Co(II).	Schiff Bases	70-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-128
17993463-8	2008	Correspondingly, both PGDM and 2,3-dinor-11beta-PGF(2alpha) were suppressed by inhibition of COX-1 and COX-2, but not by selective inhibition of COX-2 in humans.	2,3-dinor-11beta-pgf	31-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-108
18216434-3	2008	The Co(II) centres are connected by benzene-1,3,5-tricarboxylate (BTC) anions and 1,3-bis(imidazol-1-ylmethyl)benzene (L(1)) ligands into a (6(4).8(2))2(8(6))(6.8(2))2 topology framework.	benzene-1,3,5-tricarboxylate(3-)	36-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
18216434-3	2008	The Co(II) centres are connected by benzene-1,3,5-tricarboxylate (BTC) anions and 1,3-bis(imidazol-1-ylmethyl)benzene (L(1)) ligands into a (6(4).8(2))2(8(6))(6.8(2))2 topology framework.	btc	66-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
18216434-3	2008	The Co(II) centres are connected by benzene-1,3,5-tricarboxylate (BTC) anions and 1,3-bis(imidazol-1-ylmethyl)benzene (L(1)) ligands into a (6(4).8(2))2(8(6))(6.8(2))2 topology framework.	1,3-bis((1H-imidazol-1-yl)methyl)benzene	82-117	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
18216434-6	2008	The Co(II) centres are connected by BTC anions and 1,4-bis(imidazol-1-ylmethyl)benzene (L(2)) ligands into a (6(2).8(4))2(6(4).8(2))(6(3))2 framework.	btc	36-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
18216434-6	2008	The Co(II) centres are connected by BTC anions and 1,4-bis(imidazol-1-ylmethyl)benzene (L(2)) ligands into a (6(2).8(4))2(6(4).8(2))(6(3))2 framework.	1,4-Bis((1H-imidazol-1-yl)methyl)benzene	51-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
18053020-1	2008	BACKGROUND AND AIMS: Aspirin, a cyclo-oxygenase (COX)-1 and COX-2 inhibitor, is the antiplatelet drug of choice to prevent serious vascular events.	Aspirin	21-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-65
18053020-4	2008	Triflusal is a preferential COX-2 inhibitor antiplatelet agent that is as effective as aspirin in the prevention of serious vascular events.	triflusal	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
18165598-6	2008	Moreover, bupivacaine significantly increased COX-2 gene expression at 48 h as compared with the lidocaine/placebo group.	Bupivacaine	10-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
18165598-8	2008	CONCLUSIONS: These results suggest that bupivacaine stimulates COX-2 gene expression after tissue injury, which is associated with higher PGE2 production and pain after the local anesthetic effect dissipates.	Bupivacaine	40-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-68
18165598-8	2008	CONCLUSIONS: These results suggest that bupivacaine stimulates COX-2 gene expression after tissue injury, which is associated with higher PGE2 production and pain after the local anesthetic effect dissipates.	Dinoprostone	138-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-68
17485421-3	2008	Prostaglandin-E2 is the main product formed by COX-2.	Dinoprostone	0-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
17485421-10	2008	Addition of a selective COX-2 inhibitor to the IL-1beta+TNFalpha treated cartilage inhibited the enhanced prostaglandin-E2 production and almost completely normalised proteoglycan release, whereas synthesis remained unaffected.	Dinoprostone	106-122	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
17988207-5	2008	Renal cortical COX2-derived prostanoids, particularly PGI2 and PGE2, play critical roles in maintaining blood pressure and renal function in volume-contracted states.	Prostaglandins	28-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-19
17988207-5	2008	Renal cortical COX2-derived prostanoids, particularly PGI2 and PGE2, play critical roles in maintaining blood pressure and renal function in volume-contracted states.	Epoprostenol	54-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-19
17988207-5	2008	Renal cortical COX2-derived prostanoids, particularly PGI2 and PGE2, play critical roles in maintaining blood pressure and renal function in volume-contracted states.	Dinoprostone	63-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-19
17988207-6	2008	Renal medullary COX2-derived prostanoids appear to have an antihypertensive effect in individuals challenged with a high-salt diet.	Prostaglandins	29-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-20
17988207-6	2008	Renal medullary COX2-derived prostanoids appear to have an antihypertensive effect in individuals challenged with a high-salt diet.	Salts	121-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-20
17988207-10	2008	The cortical COX2-derived PGI2 participates in the pathogenesis of renal vascular hypertension through stimulating renal renin synthesis and release.	Epoprostenol	26-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-17
18389896-10	2008	Senescence markers and COX2 underexpression were also found in 3T3-F442A preadipocytes exposed for 7 weeks to stavudine or zidovudine, but not lamivudine, and in adipose tissue samples from lipodystrophic HIV-infected patients on antiretroviral regimens containing stavudine or zidovudine.	Stavudine	110-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-27
18389896-10	2008	Senescence markers and COX2 underexpression were also found in 3T3-F442A preadipocytes exposed for 7 weeks to stavudine or zidovudine, but not lamivudine, and in adipose tissue samples from lipodystrophic HIV-infected patients on antiretroviral regimens containing stavudine or zidovudine.	Zidovudine	123-133	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-27
19197392-0	2008	Coordination behavior of 3-ethoxycarbonyltetronic acid towards Cu(II) and Co(II) metal ions.	3-ethoxycarbonyltetronic acid	25-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-80
19197392-0	2008	Coordination behavior of 3-ethoxycarbonyltetronic acid towards Cu(II) and Co(II) metal ions.	Metals	81-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-80
19197392-3	2008	In this report, we present the complexation reactions of 3-ethoxycarbonyl tetronic acids with acetates and chlorides of Cu(II) and Co(II).	3-ethoxycarbonyl tetronic acids	57-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-137
19197392-3	2008	In this report, we present the complexation reactions of 3-ethoxycarbonyl tetronic acids with acetates and chlorides of Cu(II) and Co(II).	Acetates	94-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-137
19197392-3	2008	In this report, we present the complexation reactions of 3-ethoxycarbonyl tetronic acids with acetates and chlorides of Cu(II) and Co(II).	Chlorides	107-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-137
18061444-0	2008	1-Toluene-sulfonyl-3-[(3"-hydroxy-5"-substituted)-gamma-butyrolactone]-indoles: synthesis, COX-2 inhibition and anti-cancer activities.	1-toluene-sulfonyl-3-[(3"-hydroxy-5"-substituted)-gamma-butyrolactone]-indoles	0-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-96
17826030-1	2008	Prostaglandin E2 (PGE2) is a potent lipid mediator produced by the inducible form of the enzyme cyclooxygenase (COX-2) in inflammatory cells.	Dinoprostone	0-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-117
18399232-1	2008	The electronic communication between two redox centres through a Schiff base complex has been investigated in a series of ethylenediimine-bis(1-ferrocenyl-1,3-butanedionate) complexes of Zn(II) 1, Cu(II) 2, Ni(II) 3 and Co(II) 4.	Schiff Bases	65-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	220-226
18399232-1	2008	The electronic communication between two redox centres through a Schiff base complex has been investigated in a series of ethylenediimine-bis(1-ferrocenyl-1,3-butanedionate) complexes of Zn(II) 1, Cu(II) 2, Ni(II) 3 and Co(II) 4.	ethylenediimine-bis(1-ferrocenyl-1,3-butanedionate)	122-173	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	220-226
17826030-1	2008	Prostaglandin E2 (PGE2) is a potent lipid mediator produced by the inducible form of the enzyme cyclooxygenase (COX-2) in inflammatory cells.	Dinoprostone	18-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-117
17826030-7	2008	These findings demonstrate a novel property of VIP that might contribute to their anti-inflammatory effects in vivo, i.e., the inhibition of the inducible COX-2/PGE2 system.	Dinoprostone	161-165	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	155-160
17972261-3	2008	When 10 mol% of the catalysts were applied with 0.5 equivalent of NCS, a higher level of stereoselectivity was attained with the corresponding Cr(III)Cl (84% ee), Mn(II)Cl (52% ee) and Co(II) complexes (66% ee).	cr(iii)cl	143-152	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	185-191
18956402-2	2008	Co-grinding of the metal acetates of Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) with CNacacH formed a CNacac complex in all cases: mononuclear complex was formed in the cases of Mn(II), Cu(II) and Zn(II), whereas polymeric ones were formed in the cases of Fe(II), Co(II) and Ni(II).	metal acetates	19-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-51
17918755-1	2008	The coordination behaviour of a new thiosemicarbazone Schiff-base building block, N-{2-([4-N-ethylthiosemicarbazone]methyl)phenyl}-p-toluenesulfonamide, H2L1 (1), incorporating a bulky tosyl group, towards Mn II, Fe II, Co II, Ni II, Cu II, Zn II, Cd II, Ag I, Sn II, and Pb II has been investigated by means of an electrochemical preparative procedure.	thiosemicarbazone schiff-base	36-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	220-225
18956402-2	2008	Co-grinding of the metal acetates of Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) with CNacacH formed a CNacac complex in all cases: mononuclear complex was formed in the cases of Mn(II), Cu(II) and Zn(II), whereas polymeric ones were formed in the cases of Fe(II), Co(II) and Ni(II).	metal acetates	19-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	263-269
18956402-2	2008	Co-grinding of the metal acetates of Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) with CNacacH formed a CNacac complex in all cases: mononuclear complex was formed in the cases of Mn(II), Cu(II) and Zn(II), whereas polymeric ones were formed in the cases of Fe(II), Co(II) and Ni(II).	Manganese(2+)	37-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	263-269
18956402-2	2008	Co-grinding of the metal acetates of Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) with CNacacH formed a CNacac complex in all cases: mononuclear complex was formed in the cases of Mn(II), Cu(II) and Zn(II), whereas polymeric ones were formed in the cases of Fe(II), Co(II) and Ni(II).	Nickel(2+)	53-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	263-269
18956402-2	2008	Co-grinding of the metal acetates of Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) with CNacacH formed a CNacac complex in all cases: mononuclear complex was formed in the cases of Mn(II), Cu(II) and Zn(II), whereas polymeric ones were formed in the cases of Fe(II), Co(II) and Ni(II).	cu(ii)	61-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	263-269
18956402-2	2008	Co-grinding of the metal acetates of Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) with CNacacH formed a CNacac complex in all cases: mononuclear complex was formed in the cases of Mn(II), Cu(II) and Zn(II), whereas polymeric ones were formed in the cases of Fe(II), Co(II) and Ni(II).	Zinc	72-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	263-269
18956402-2	2008	Co-grinding of the metal acetates of Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) with CNacacH formed a CNacac complex in all cases: mononuclear complex was formed in the cases of Mn(II), Cu(II) and Zn(II), whereas polymeric ones were formed in the cases of Fe(II), Co(II) and Ni(II).	Manganese(2+)	177-183	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-51
18956402-2	2008	Co-grinding of the metal acetates of Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) with CNacacH formed a CNacac complex in all cases: mononuclear complex was formed in the cases of Mn(II), Cu(II) and Zn(II), whereas polymeric ones were formed in the cases of Fe(II), Co(II) and Ni(II).	cu(ii)	185-191	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-51
18956402-2	2008	Co-grinding of the metal acetates of Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) with CNacacH formed a CNacac complex in all cases: mononuclear complex was formed in the cases of Mn(II), Cu(II) and Zn(II), whereas polymeric ones were formed in the cases of Fe(II), Co(II) and Ni(II).	Zinc	196-202	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-51
18956402-2	2008	Co-grinding of the metal acetates of Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) with CNacacH formed a CNacac complex in all cases: mononuclear complex was formed in the cases of Mn(II), Cu(II) and Zn(II), whereas polymeric ones were formed in the cases of Fe(II), Co(II) and Ni(II).	ammonium ferrous sulfate	255-261	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-51
18956402-2	2008	Co-grinding of the metal acetates of Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) with CNacacH formed a CNacac complex in all cases: mononuclear complex was formed in the cases of Mn(II), Cu(II) and Zn(II), whereas polymeric ones were formed in the cases of Fe(II), Co(II) and Ni(II).	Nickel(2+)	274-280	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-51
17972261-1	2008	The previously developed enantioselective iodocyclization of gamma-hydroxy-cis-alkenes required 30 mol% of (R,R)-salen-Co(II) complex as chiral catalyst and 0.75 equivalent of N-chlorosuccinimide (NCS) as activator to produce 2-substituted tetrahydrofurans with 61 to 90% ee.	gamma-hydroxy-cis-alkenes	61-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-125
17972261-2	2008	Due to the considerable loading amount of the Co(II) complex, another more effective catalyst was pursued by screening (R,R)-salen-transition metal complexes.	(R,R)-Salen	119-130	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-52
17972261-2	2008	Due to the considerable loading amount of the Co(II) complex, another more effective catalyst was pursued by screening (R,R)-salen-transition metal complexes.	Metals	142-147	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-52
18810744-5	2008	Contrary to 1 a and 1 b, in 2 a and 2 b the vanadate chains link Co(II) cations to generate 3D chiral inorganic skeletons, which are assembled from two kinds of heterometallic helical units of opposite chirality along the c axes.	Vanadates	44-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-71
17918755-1	2008	The coordination behaviour of a new thiosemicarbazone Schiff-base building block, N-{2-([4-N-ethylthiosemicarbazone]methyl)phenyl}-p-toluenesulfonamide, H2L1 (1), incorporating a bulky tosyl group, towards Mn II, Fe II, Co II, Ni II, Cu II, Zn II, Cd II, Ag I, Sn II, and Pb II has been investigated by means of an electrochemical preparative procedure.	N-(2-((4-N-ethylthiosemicarbazone)methyl)phenyl)-p-toluenesulfonamide	82-151	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	220-225
18220714-9	2008	This review will summarize current evidence supporting the role of COX-2 activation in inducing diabetic neurovascular dysfunction and that modulation of the COX-2 pathway is a potential therapeutic target for DPN.	dpn	210-213	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	158-163
18090373-9	2008	The COX-1 and COX-2 inhibitor aspirin (10(-6)-10(-5) mol/L) and the COX-2 inhibitor nimesulide (10(-6) mol/L) induced leftward shifts of the concentration-response curve for vasopressin in gastroepiploic artery.	Aspirin	30-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
18090373-9	2008	The COX-1 and COX-2 inhibitor aspirin (10(-6)-10(-5) mol/L) and the COX-2 inhibitor nimesulide (10(-6) mol/L) induced leftward shifts of the concentration-response curve for vasopressin in gastroepiploic artery.	nimesulide	84-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-73
18090373-12	2008	CONCLUSION: The results provide functional evidence that aspirin at high concentrations and the COX-2 selective inhibitor nimesulide potentiate the contractile response of gastroepiploic artery to vasopressin, thus suggesting the release of relaxant prostaglandins by the peptide.	nimesulide	122-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-101
18090373-12	2008	CONCLUSION: The results provide functional evidence that aspirin at high concentrations and the COX-2 selective inhibitor nimesulide potentiate the contractile response of gastroepiploic artery to vasopressin, thus suggesting the release of relaxant prostaglandins by the peptide.	Prostaglandins	250-264	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-101
19105570-5	2008	We recently found that adaptive Treg cells express COX-2 and suppress responder T cells in a PGE2-cAMP-dependent manner, which can be reversed by COX-2 inhibitors or EP-receptor antagonists.	Dinoprostone	93-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-56
18690976-1	2008	The withdrawal of the celebrity arthritis drug, rofecoxib (Vioxx) has sparked an intense discussion and controversy about the safety of the selective COX-2 inhibitors.	rofecoxib	48-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	150-155
19105570-5	2008	We recently found that adaptive Treg cells express COX-2 and suppress responder T cells in a PGE2-cAMP-dependent manner, which can be reversed by COX-2 inhibitors or EP-receptor antagonists.	Dinoprostone	93-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	146-151
19105570-5	2008	We recently found that adaptive Treg cells express COX-2 and suppress responder T cells in a PGE2-cAMP-dependent manner, which can be reversed by COX-2 inhibitors or EP-receptor antagonists.	Cyclic AMP	98-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-56
19105570-5	2008	We recently found that adaptive Treg cells express COX-2 and suppress responder T cells in a PGE2-cAMP-dependent manner, which can be reversed by COX-2 inhibitors or EP-receptor antagonists.	Cyclic AMP	98-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	146-151
18350888-3	2008	A potential risk in quantifying exchangeable Co in soils using isotope dilution techniques is the possible presence of two species of Co in soil solution and adsorbed on soil solid phases [Co(II) and Co(III)], coupled with the possibility that when an isotope of Co is added it may undergo a change in oxidation state during the measurement phase.	Cobalt	134-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	189-195
18182814-1	2008	Etoricoxib is a new, highly selective cyclooxygenase (COX) 2 inhibitor, reported to have an increased cutaneous and systemic safety profile compared to the previous COX-2 inhibitors, including celecoxib, rofecoxib and valdecoxib.	Etoricoxib	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-60
18182814-1	2008	Etoricoxib is a new, highly selective cyclooxygenase (COX) 2 inhibitor, reported to have an increased cutaneous and systemic safety profile compared to the previous COX-2 inhibitors, including celecoxib, rofecoxib and valdecoxib.	Etoricoxib	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	165-170
18171381-0	2008	Primary stabbing headache can be responsive to etoricoxib, a selective COX-2 inhibitor.	Etoricoxib	47-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-76
17965142-7	2008	In diseased vessels, inducible forms of NOS (NOSII) and cyclo-oxygeanse (COX-2) are expressed in vascular smooth muscle, resulting in the release of large amounts of NO, prostacyclin and prostaglandin E2.	Epoprostenol	170-182	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-78
17965142-7	2008	In diseased vessels, inducible forms of NOS (NOSII) and cyclo-oxygeanse (COX-2) are expressed in vascular smooth muscle, resulting in the release of large amounts of NO, prostacyclin and prostaglandin E2.	Dinoprostone	187-203	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-78
18171312-4	2008	Similarly to other coxibs and some traditional (t)NSAIDs less selective for COX-2, such as diclofenac, valdecoxib may increase the risk of thrombotic events through a prostacyclin-based mechanism.	valdecoxib	103-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-81
18171312-5	2008	The rapid and elevated thrombotic risk detected in two coronary artery bypass graft surgery trials with parecoxib and valdecoxib is coherent with almost complete suppression of COX-2 by supratherapeutic doses (particularly parecoxib), which plausibly translates into a deep suppression of prostacyclin.	parecoxib	223-232	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	177-182
18171312-5	2008	The rapid and elevated thrombotic risk detected in two coronary artery bypass graft surgery trials with parecoxib and valdecoxib is coherent with almost complete suppression of COX-2 by supratherapeutic doses (particularly parecoxib), which plausibly translates into a deep suppression of prostacyclin.	Epoprostenol	289-301	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	177-182
18171312-6	2008	Drug potency, that is, the degree of suppression of COX-2-dependent prostacyclin, is proposed to represent a strong determinant in the increased incidence of thrombotic events associated with the use of COX-2 inhibitors and some tNSAIDs.	Epoprostenol	68-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-57
18171312-6	2008	Drug potency, that is, the degree of suppression of COX-2-dependent prostacyclin, is proposed to represent a strong determinant in the increased incidence of thrombotic events associated with the use of COX-2 inhibitors and some tNSAIDs.	Epoprostenol	68-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	203-208
18068105-0	2008	Janus kinase 3 inhibitor WHI-P154 in macrophages activated by bacterial endotoxin: differential effects on the expression of iNOS, COX-2 and TNF-alpha.	WHI P154	25-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-136
18336751-0	2008	Parecoxib as an alternative in COX-2 hypersensitivity.	parecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-36
18336751-4	2008	Parecoxib is the first injectable COX-2 selective inhibitor indicated for the treatment of acute postoperative pain.	parecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-39
18336751-5	2008	The authors report the case of a patient with a history of cutaneous adverse reactions to different classes of NSAIDs, including selective COX-2 inhibitors, who underwent and tolerated challenge with parecoxib.	parecoxib	200-209	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-144
18173398-3	2008	COX-2, which is induced in an inflammatory response, is responsible for PGs synthesis at sites of inflammation.	Phosphatidylglycerols	72-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
18564626-3	2008	Here we report the safety and tolerability of etoricoxib, a selective COX-2 inhibitor with fewer cardiovascular effects, in patients with adverse reactions to NSAIDs.	Etoricoxib	46-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-75
17933588-1	2008	UNLABELLED: This randomized, double-blinded, double-dummy, parallel-group, single-center study compared a single dose of the novel selective COX-2 inhibitor lumiracoxib (400 mg), with celecoxib (400 mg) or placebo in dental pain.	lumiracoxib	157-168	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	141-146
17933588-10	2008	PERSPECTIVE: In a randomized, double-blinded, double-dummy, parallel-group, single-center study, a single dose of the novel selective COX-2 inhibitor lumiracoxib (400 mg) was well-tolerated and provided significantly superior analgesia to 400 mg celecoxib or placebo in patients with moderate-to-severe dental pain after surgical extraction of impacted molars.	lumiracoxib	150-161	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-139
18220987-2	2008	COX-1 and COX-2 play key roles in the metabolism of arachidonic acid.	Arachidonic Acid	52-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
18220987-3	2008	The enzyme COX-2, when over expressed, leads to more production of prostaglandins causing inflammation and it also participates in the propagation of cancer.	Prostaglandins	67-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-16
18094075-11	2008	Pharmacological inhibition indicated that stretch-induced COX-2 expression is dependent on calcium and PKC, and biochemical knockdown experiments indicated that PKCzeta is the predominant isoform mediating stretch-induced COX-2 expression.	Calcium	91-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
17963198-0	2008	Large-scale stopping and switching treatment with COX-2 inhibitors after the rofecoxib withdrawal.	rofecoxib	77-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-55
18289124-1	2008	Celecoxib (Celebrex, Pfizer, NY, USA) is a worldwide top branded COX-2-specific inhibitor.	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-70
18289124-1	2008	Celecoxib (Celebrex, Pfizer, NY, USA) is a worldwide top branded COX-2-specific inhibitor.	Celecoxib	11-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-70
18289124-4	2008	We discovered that the addition of curcumin, a natural COX-2 inhibitor, to celecoxib synergistically (up to 1000%) augments the growth inhibitory effects of celecoxib in in-vitro and in-vivo models of arthritis and cancer, thus rendering effective action of the drug at up to tenfold lower dose.	Curcumin	35-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-60
18289124-4	2008	We discovered that the addition of curcumin, a natural COX-2 inhibitor, to celecoxib synergistically (up to 1000%) augments the growth inhibitory effects of celecoxib in in-vitro and in-vivo models of arthritis and cancer, thus rendering effective action of the drug at up to tenfold lower dose.	Celecoxib	75-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-60
18289124-4	2008	We discovered that the addition of curcumin, a natural COX-2 inhibitor, to celecoxib synergistically (up to 1000%) augments the growth inhibitory effects of celecoxib in in-vitro and in-vivo models of arthritis and cancer, thus rendering effective action of the drug at up to tenfold lower dose.	Celecoxib	157-166	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-60
18185149-4	2008	Multivariable analysis was used to assess the independent correlation of COX-2 inhibitor usage with RVO.	rvo	100-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-78
18185149-12	2008	CONCLUSION: A few patients with RVO had prior or concurrent use of COX-2 inhibitors.	rvo	32-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-72
18295304-6	2008	In 10 COX-2 positive patients with TxA2 levels over the median, AA-induced TxA2 production performed in vitro in the presence of the COX-2 inhibitor CAY10404 and aspirin demonstrated that COX-2 dependent TxA2 production is less than 2%.	3-(4-methylsulfonylphenyl)-4-phenyl-5-trifluoromethylisoxazole	149-157	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	133-138
18295304-6	2008	In 10 COX-2 positive patients with TxA2 levels over the median, AA-induced TxA2 production performed in vitro in the presence of the COX-2 inhibitor CAY10404 and aspirin demonstrated that COX-2 dependent TxA2 production is less than 2%.	3-(4-methylsulfonylphenyl)-4-phenyl-5-trifluoromethylisoxazole	149-157	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	133-138
18156036-10	2007	Data support the conclusion that COX-2 inhibitors are preferable to non-selective NSAIDs in patients with chronic pain and cardiovascular risk needing low-dose aspirin, but relative risks and benefits should be assessed individually for each patient.	Aspirin	160-167	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-38
18026596-0	2007	Bis(ketopyrrolyl) complexes of Co(II) stabilised by trimethylphosphine ligands.	bis(ketopyrrolyl)	0-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-37
18026596-0	2007	Bis(ketopyrrolyl) complexes of Co(II) stabilised by trimethylphosphine ligands.	trimethyl phosphine	52-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-37
17936921-11	2007	Our results showed that gastrin transactivates the COX-2 promoter in both Colo320 cells and COS-7 cells expressing the CCK-2i4svR cDNA.	carbonyl sulfide	92-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-56
18057610-1	2007	The title compound, [Co(C7H6NO2)2(H2O)4] x 4 H2O, contains a Co(II) ion lying on a crystallographic inversion centre.	co(c7h6no2)2(h2o)4	21-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-67
18057610-1	2007	The title compound, [Co(C7H6NO2)2(H2O)4] x 4 H2O, contains a Co(II) ion lying on a crystallographic inversion centre.	Water	34-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-67
18057610-2	2007	The Co(II) ion is octahedrally coordinated by two 6-methylpyridine-3-carboxylate ligands in axial positions [Co-O = 2.0621 (9) A] and by four water molecules in the equatorial plane [Co-O = 2.1169 (9) and 2.1223 (11) A].	6-methylpyridine-3-carboxylate	50-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
18057610-2	2007	The Co(II) ion is octahedrally coordinated by two 6-methylpyridine-3-carboxylate ligands in axial positions [Co-O = 2.0621 (9) A] and by four water molecules in the equatorial plane [Co-O = 2.1169 (9) and 2.1223 (11) A].	carboxyl radical	109-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
18057610-2	2007	The Co(II) ion is octahedrally coordinated by two 6-methylpyridine-3-carboxylate ligands in axial positions [Co-O = 2.0621 (9) A] and by four water molecules in the equatorial plane [Co-O = 2.1169 (9) and 2.1223 (11) A].	Water	142-147	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
18057610-2	2007	The Co(II) ion is octahedrally coordinated by two 6-methylpyridine-3-carboxylate ligands in axial positions [Co-O = 2.0621 (9) A] and by four water molecules in the equatorial plane [Co-O = 2.1169 (9) and 2.1223 (11) A].	carboxyl radical	183-187	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
18057610-4	2007	The 6-methylpyridine-3-carboxylate ligands are bound to the Co(II) ion in a monodentate manner through a carboxylate O atom.	6-methylpyridine-3-carboxylate	4-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-66
18057610-4	2007	The 6-methylpyridine-3-carboxylate ligands are bound to the Co(II) ion in a monodentate manner through a carboxylate O atom.	carboxylate	23-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-66
18031619-8	2007	Compound A, 1,3,6,7-tetrahydroxyxanthone, revealed high inhibitory potency to both COX-1 and COX-2.	1,3,6,7-tetrahydroxyxanthone	12-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-98
18031619-11	2007	Compound F, a potent agent for COX-2, revealed a strong hydrogen bond with Ser516 in human COX-2 to form a stable complex.	Hydrogen	56-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-36
18031619-11	2007	Compound F, a potent agent for COX-2, revealed a strong hydrogen bond with Ser516 in human COX-2 to form a stable complex.	Hydrogen	56-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-96
17965743-7	2007	The selective COX-2 inhibitor lumiracoxib shared this activity profile, whereas a number of standard NSAIDs and other selective COX-2 inhibitors did not.	lumiracoxib	30-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
17965743-8	2007	CONCLUSIONS AND IMPLICATIONS: Diclofenac and lumiracoxib, in addition to being COX unselective and highly COX-2 selective inhibitors, respectively, displayed a previously unknown pharmacological activity, namely TP receptor antagonism.	Diclofenac	30-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-111
17965743-8	2007	CONCLUSIONS AND IMPLICATIONS: Diclofenac and lumiracoxib, in addition to being COX unselective and highly COX-2 selective inhibitors, respectively, displayed a previously unknown pharmacological activity, namely TP receptor antagonism.	lumiracoxib	45-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-111
17965743-9	2007	Development of COX-2 selective inhibitors with dual activity as potent TP antagonists may lead to coxibs with improved cardiovascular safety, as the TP receptor mediates cardiovascular effects of thromboxane A2 and isoprostanes.	Thromboxane A2	196-210	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-20
17965743-9	2007	Development of COX-2 selective inhibitors with dual activity as potent TP antagonists may lead to coxibs with improved cardiovascular safety, as the TP receptor mediates cardiovascular effects of thromboxane A2 and isoprostanes.	Isoprostanes	215-227	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-20
23392784-4	2007	Following peripheral trauma or injury, inflammatory mediators such as phospholipase A(2) are upregulated, inducing the release of arachidonic acid, which is then converted to prostanoids such as prostaglandin E(2) (PGE(2)) via the action of the enzyme cyclo-oxygenase (COX)-2.	Arachidonic Acid	130-146	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	252-275
23392784-4	2007	Following peripheral trauma or injury, inflammatory mediators such as phospholipase A(2) are upregulated, inducing the release of arachidonic acid, which is then converted to prostanoids such as prostaglandin E(2) (PGE(2)) via the action of the enzyme cyclo-oxygenase (COX)-2.	Prostaglandins	175-186	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	252-275
23392784-4	2007	Following peripheral trauma or injury, inflammatory mediators such as phospholipase A(2) are upregulated, inducing the release of arachidonic acid, which is then converted to prostanoids such as prostaglandin E(2) (PGE(2)) via the action of the enzyme cyclo-oxygenase (COX)-2.	Dinoprostone	195-213	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	252-275
23392784-4	2007	Following peripheral trauma or injury, inflammatory mediators such as phospholipase A(2) are upregulated, inducing the release of arachidonic acid, which is then converted to prostanoids such as prostaglandin E(2) (PGE(2)) via the action of the enzyme cyclo-oxygenase (COX)-2.	Prostaglandins E	215-218	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	252-275
23392785-6	2007	Results from clinical studies in these patient groups show that NSAIDs such as nimesulide, with its preferential inhibitory activity on the COX-2 isoform and the lack of a topical effect, do not influence the evolution of IBD in patients requiring NSAID treatment for concomitant arthritic complaints.	nimesulide	79-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-145
23392786-5	2007	The NSAID nimesulide, along with its preferential activity on COX-2 and a short half-life that correlates with a rapid onset of analgesic action, acts also through a variety of COX-independent pathways that contributes to its potent antiinflammatory and analgesic activity.	nimesulide	10-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
17872375-7	2007	Treatment with E(2) or raloxifene increased both IGF-I and cyclooxygenase (COX)-2 mRNA expression in HUVECs, whereas they attenuated the serum-induced increase of these genes in HASMCs.	Estradiol	15-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-81
17872375-7	2007	Treatment with E(2) or raloxifene increased both IGF-I and cyclooxygenase (COX)-2 mRNA expression in HUVECs, whereas they attenuated the serum-induced increase of these genes in HASMCs.	Raloxifene Hydrochloride	23-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-81
17872375-8	2007	Treatment by E(2) and raloxifene induced recruitment of coactivator complex and histone acetylation at both the IGF-I and COX-2 gene promoter in HUVECs.	Estradiol	13-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-127
17872375-8	2007	Treatment by E(2) and raloxifene induced recruitment of coactivator complex and histone acetylation at both the IGF-I and COX-2 gene promoter in HUVECs.	Raloxifene Hydrochloride	22-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-127
17872375-9	2007	In contrast, in HASMCs, E(2), and raloxifene attenuated the serum-induced recruitment of coactivator complexes and histone acetylation at both the IGF-I and COX-2 gene promoters.	hasmcs	16-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	157-162
17872375-9	2007	In contrast, in HASMCs, E(2), and raloxifene attenuated the serum-induced recruitment of coactivator complexes and histone acetylation at both the IGF-I and COX-2 gene promoters.	Estradiol	24-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	157-162
17872375-9	2007	In contrast, in HASMCs, E(2), and raloxifene attenuated the serum-induced recruitment of coactivator complexes and histone acetylation at both the IGF-I and COX-2 gene promoters.	Raloxifene Hydrochloride	34-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	157-162
17872375-10	2007	Estrogen and raloxifene exert divergent transcriptional regulation on both mRNA expression and the remodeling of IGF-I and COX-2 gene promoters in HUVECs vs. HASMCs.	Raloxifene Hydrochloride	13-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-128
18690976-1	2008	The withdrawal of the celebrity arthritis drug, rofecoxib (Vioxx) has sparked an intense discussion and controversy about the safety of the selective COX-2 inhibitors.	rofecoxib	59-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	150-155
18477251-9	2008	Gene expression of PGES is strongly correlated with other mediators of the prostaglandin biosynthetic pathway, that is both COX isoforms (COX-1 and COX-2).	Prostaglandins	75-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	148-153
18350888-3	2008	A potential risk in quantifying exchangeable Co in soils using isotope dilution techniques is the possible presence of two species of Co in soil solution and adsorbed on soil solid phases [Co(II) and Co(III)], coupled with the possibility that when an isotope of Co is added it may undergo a change in oxidation state during the measurement phase.	Cobalt	134-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	189-195
18156308-1	2008	Since recombinant human cyclooxygenase (COX) enzymes have been shown to activate environmental and dietary carcinogens implicated in human colorectal cancer etiology, we hypothesized that COX-2 inhibitors reduce arylamine-induced aberrant crypts (AC) and foci (ACF), preneoplastic lesions of colorectal cancer.	aniline	212-221	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	188-193
18171312-1	2008	Valdecoxib is an NSAID that is selective for COX-2 (commonly named coxibs).	valdecoxib	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-50
18171312-2	2008	It exhibits anti-inflammatory, analgesic and antipyretic properties in animal models and humans due to inhibition of prostanoid synthesis primarily by affecting COX-2.	Prostaglandins	117-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	161-166
17996386-0	2008	Celecoxib induced tumor cell radiosensitization by inhibiting radiation induced nuclear EGFR transport and DNA-repair: a COX-2 independent mechanism.	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-126
17996386-1	2008	PURPOSE: The purpose of the study was to elucidate the molecular mechanisms mediating radiosensitization of human tumor cells by the selective cyclooxygenase (COX)-2 inhibitor celecoxib.	Celecoxib	176-185	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	143-165
18705272-3	2008	In view of the ulcerogenic potential of NSAIDs and the cardiotoxicity problems associated with COX-2 inhibitors, diacerein has the potential of being a non-ulcerogenic and non-cardiotoxic alternative respectively to NSAIDs and of COX-2 inhibitors in the treatment of osteo-arthritis.	diacerein	113-122	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-100
18705272-3	2008	In view of the ulcerogenic potential of NSAIDs and the cardiotoxicity problems associated with COX-2 inhibitors, diacerein has the potential of being a non-ulcerogenic and non-cardiotoxic alternative respectively to NSAIDs and of COX-2 inhibitors in the treatment of osteo-arthritis.	diacerein	113-122	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	230-235
18166099-2	2008	In this double-masked, placebo-controlled, randomized clinical trial, the efficacy of celecoxib (COX-2 inhibitor) was evaluated in conjunction with scaling and root planing (SRP) in subjects with chronic periodontitis (CP).	Celecoxib	86-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
18642053-6	2008	However, certain conventional NSAIDs and celecoxib, a selective COX-2 inhibitor, have been reported to inhibit synovial hyperplasia by inducing the apoptosis of human synovial fibroblasts.	Celecoxib	41-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-69
18348652-5	2008	However, It is unknown whether COX-2 inhibitor can augment the efficacy of gemcitabine against lung adenocarcinoma.	gemcitabine	75-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-36
19024285-5	2008	Meloxicam is COX-2 selective NSAID with favourable gastrointestinal and thromboembolic safety profile.	Meloxicam	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
17584993-15	2008	Thus, PGE2 is released during the clinical reactions to aspirin through an alternative COX-2 pathway.	Dinoprostone	6-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-92
17584993-15	2008	Thus, PGE2 is released during the clinical reactions to aspirin through an alternative COX-2 pathway.	Aspirin	56-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-92
17584993-16	2008	The clinical implications of this finding are in line with current observations of good tolerance of the selective COX-2 inhibitors in aspirin-sensitive patients.	Aspirin	135-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-120
18155912-7	2008	This can occur because of unique biochemical properties of COX-2 that enable cells to form prostaglandins when arachidonic acid comprises a small fraction of available fatty acids and the concentrations of peroxides that are necessary for COX to function are low.	Prostaglandins	91-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-64
18155912-7	2008	This can occur because of unique biochemical properties of COX-2 that enable cells to form prostaglandins when arachidonic acid comprises a small fraction of available fatty acids and the concentrations of peroxides that are necessary for COX to function are low.	Arachidonic Acid	111-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-64
18155912-7	2008	This can occur because of unique biochemical properties of COX-2 that enable cells to form prostaglandins when arachidonic acid comprises a small fraction of available fatty acids and the concentrations of peroxides that are necessary for COX to function are low.	Fatty Acids	168-179	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-64
18155912-7	2008	This can occur because of unique biochemical properties of COX-2 that enable cells to form prostaglandins when arachidonic acid comprises a small fraction of available fatty acids and the concentrations of peroxides that are necessary for COX to function are low.	Peroxides	206-215	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-64
21200573-1	2007	In the crystal structure of the title compound, [Co(C(10)H(4)Cl(2)NO(2))(2)](n), the Co(II) cation lies on a twofold rotation axis.	co(c(10)h	49-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-90
21200573-1	2007	In the crystal structure of the title compound, [Co(C(10)H(4)Cl(2)NO(2))(2)](n), the Co(II) cation lies on a twofold rotation axis.	(4)cl(2)no(2))(	58-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-90
21200573-3	2007	The second carboxyl-ate O atom of each ligand coordinates to the Co(II) cation of an adjacent mol-ecule, linking the cations into a linear chain.	carboxyl-ate o	11-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-70
21200472-1	2007	The title mol-ecule, [Co(C(6)H(5))(CN)(C(3)H(9)P)(3)], lies on a crystallographic mirror plane with the Co(II) ion coordinated in a distorted square-pyramidal environment with one of the P atoms in the apical position.	co(c(6)h(5))	22-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-110
21200472-1	2007	The title mol-ecule, [Co(C(6)H(5))(CN)(C(3)H(9)P)(3)], lies on a crystallographic mirror plane with the Co(II) ion coordinated in a distorted square-pyramidal environment with one of the P atoms in the apical position.	c(3)h(9)p)	39-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-110
21200630-1	2007	In the centrosymmetric title complex, [Co(C(7)H(4)NO(3)S)(2)(C(6)H(15)N(3))(2)], the Co(II) ion is coordinated by two saccharinate (sac) anions and two neutral 2-piperazin-1-ylethanamine (ppzea) ligands, showing a distorted octa-hedral coordination.	co(c(7)h(4)no(3)s)	39-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-91
21200630-1	2007	In the centrosymmetric title complex, [Co(C(7)H(4)NO(3)S)(2)(C(6)H(15)N(3))(2)], the Co(II) ion is coordinated by two saccharinate (sac) anions and two neutral 2-piperazin-1-ylethanamine (ppzea) ligands, showing a distorted octa-hedral coordination.	1,1-dioxo-1,2-benzothiazol-3-olate	118-130	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-91
21200630-1	2007	In the centrosymmetric title complex, [Co(C(7)H(4)NO(3)S)(2)(C(6)H(15)N(3))(2)], the Co(II) ion is coordinated by two saccharinate (sac) anions and two neutral 2-piperazin-1-ylethanamine (ppzea) ligands, showing a distorted octa-hedral coordination.	N-Aminoethylpiperazine	160-186	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-91
21200630-1	2007	In the centrosymmetric title complex, [Co(C(7)H(4)NO(3)S)(2)(C(6)H(15)N(3))(2)], the Co(II) ion is coordinated by two saccharinate (sac) anions and two neutral 2-piperazin-1-ylethanamine (ppzea) ligands, showing a distorted octa-hedral coordination.	ppzea	188-193	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-91
17604853-9	2007	Gastrin stimulated the PGE2-generation and COX-2-mRNA expression in human Colo-320-B cells potently, obviously by transactivating the COX-2-promoter using a region between - 68 bp and + 70 bp.	Dinoprostone	23-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-139
18053191-1	2007	BACKGROUND: COX-2 inhibitors, such as celecoxib, and ubiquitin-proteasome pathway inhibitors, such as bortezomib, can down-regulate NF-kappaB, a transcription factor implicated in tumor growth.	Celecoxib	38-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-17
18053191-1	2007	BACKGROUND: COX-2 inhibitors, such as celecoxib, and ubiquitin-proteasome pathway inhibitors, such as bortezomib, can down-regulate NF-kappaB, a transcription factor implicated in tumor growth.	Bortezomib	102-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-17
18045954-5	2007	MCF7 cells, expressing COX-2 but not MDR1, were treated with increasing doses of doxorubicin, and they became chemoresistant after 10 days of treatment, in association with MDR1 expression induction.	Doxorubicin	81-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-28
18045954-6	2007	This effect was reversed by doxorubicin withdrawal and prevented by co-incubation with N-[2-(cyclohexyloxy)4-nitrophenyl]-methanesulfonamide (NS-398), a selective COX-2 inhibitor.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	87-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	163-168
18045954-6	2007	This effect was reversed by doxorubicin withdrawal and prevented by co-incubation with N-[2-(cyclohexyloxy)4-nitrophenyl]-methanesulfonamide (NS-398), a selective COX-2 inhibitor.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	142-148	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	163-168
18090122-0	2007	Efficacy of sulforaphane is mediated by p38 MAP kinase and caspase-7 activations in ER-positive and COX-2-expressed human breast cancer cells.	sulforaphane	12-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-105
17893865-5	2007	For example, 1"-acetoxychavicol acetate, which occurs in the rhizomes of the subtropical Zingiberaceae plant, has been shown to attenuate NOX-derived superoxide generation in macrophages, as well as lipopolysaccharide-induced nitric oxide and prostaglandin E(2) production through the suppression of iNOS and COX-2 synthesis, respectively.	1'-acetoxychavicol acetate	13-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	309-314
17893865-5	2007	For example, 1"-acetoxychavicol acetate, which occurs in the rhizomes of the subtropical Zingiberaceae plant, has been shown to attenuate NOX-derived superoxide generation in macrophages, as well as lipopolysaccharide-induced nitric oxide and prostaglandin E(2) production through the suppression of iNOS and COX-2 synthesis, respectively.	Superoxides	150-160	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	309-314
18025237-3	2007	Incubation of HCAEC monolayers with histamine resulted in marked increases in the expression of COX-2 and production of PGI(2) and PGE(2) with no significant change in the expression of COX-1.	Histamine	36-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-101
17965845-1	2007	Non-steroidal antiphlogistics and COX-2 inhibitors routinely cause sodium retention and a blood pressure increase by about 5 mmHg, a decrease in renal function (by about 10 ml/min) and in 1-2% an acute renal failure.	Sodium	67-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-39
18028081-5	2007	Use of paracetamol-containing medicines was overtaken by NSAIDs in 1999/2000, corresponding to the introduction of the Cox-2-selective agents.	Acetaminophen	7-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-124
18025237-4	2007	Histamine-induced increases in PGI(2) and PGE(2) production were due to increased expression and function of COX-2 because gene silencing by small interfering RNA or inhibition of the catalytic activity by a COX-2 inhibitor blocked prostanoid production.	Histamine	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-114
18025237-4	2007	Histamine-induced increases in PGI(2) and PGE(2) production were due to increased expression and function of COX-2 because gene silencing by small interfering RNA or inhibition of the catalytic activity by a COX-2 inhibitor blocked prostanoid production.	Histamine	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	208-213
18025237-4	2007	Histamine-induced increases in PGI(2) and PGE(2) production were due to increased expression and function of COX-2 because gene silencing by small interfering RNA or inhibition of the catalytic activity by a COX-2 inhibitor blocked prostanoid production.	Epoprostenol	31-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-114
18025237-4	2007	Histamine-induced increases in PGI(2) and PGE(2) production were due to increased expression and function of COX-2 because gene silencing by small interfering RNA or inhibition of the catalytic activity by a COX-2 inhibitor blocked prostanoid production.	Epoprostenol	31-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	208-213
18025237-4	2007	Histamine-induced increases in PGI(2) and PGE(2) production were due to increased expression and function of COX-2 because gene silencing by small interfering RNA or inhibition of the catalytic activity by a COX-2 inhibitor blocked prostanoid production.	Dinoprostone	42-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-114
18025237-4	2007	Histamine-induced increases in PGI(2) and PGE(2) production were due to increased expression and function of COX-2 because gene silencing by small interfering RNA or inhibition of the catalytic activity by a COX-2 inhibitor blocked prostanoid production.	Prostaglandins	232-242	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-114
18025237-4	2007	Histamine-induced increases in PGI(2) and PGE(2) production were due to increased expression and function of COX-2 because gene silencing by small interfering RNA or inhibition of the catalytic activity by a COX-2 inhibitor blocked prostanoid production.	Prostaglandins	232-242	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	208-213
18025237-5	2007	The effects of histamine on COX-2 expression and prostanoid production were mediated through H(1) receptors.	Histamine	15-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
18025237-6	2007	In addition to the direct effect, histamine was found to amplify LPS-stimulated COX-2 expression and PGE(2) and PGI(2) production.	Histamine	34-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-85
18025237-10	2007	Thus, histamine plays an important role in the regulation of COX-2 expression and prostanoid homeostasis in vascular endothelium.	Histamine	6-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-66
17477358-10	2007	COX-2 protein was strongly expressed in 46% (10/22) of EADCs, and was associated with a trend towards reduced disease-free survival.	eadcs	55-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
18025237-2	2007	In this study, we investigated the effects of histamine on the expression of COX-1 and COX-2 and determined their contribution to the production of PGE(2), prostacyclin (PGI(2)), and thromboxane A(2) in human coronary artery endothelial cells (HCAEC).	Histamine	46-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-92
17976742-0	2007	Neuroprotection with pioglitazone against LPS insult on dopaminergic neurons may be associated with its inhibition of NF-kappaB and JNK activation and suppression of COX-2 activity.	Pioglitazone	21-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	166-171
17855475-13	2007	6-OHDA-induced overexpression of nNOS, iNOS, COX-2, and gp91(phox) was also reduced by GLNVA.	Oxidopamine	0-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-50
17855475-13	2007	6-OHDA-induced overexpression of nNOS, iNOS, COX-2, and gp91(phox) was also reduced by GLNVA.	N-(4-O-glycerol-3-methoxybenzyl)nonivamide	87-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-50
18159171-9	2007	It is assumed that endogenous PGs are involved in the mucosal defense against DSS-induced colonic ulcerations which are produced by COX-1 at early phase and by COX-2 at late phase.	Phosphatidylglycerols	30-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	160-165
18064329-9	2007	Evolutionary, this mechanism may prevent COX-2-dependent thromboxane synthesis in the platelet, which would potentiate the likelihood of thrombosis; pharmacologically, this mechanism would prevent an aspirin-insensitive pathway of thromboxane formation.	Thromboxanes	57-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-46
17639563-4	2007	The methanol extract was most active in both assays with IC(50) values of 12 microg/mL for COX-1 and 19 microg/mL for COX-2.	Methanol	4-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-123
17999354-6	2007	The substance, acting in concert with honey flavonoids (COX-2 inhibitors), by antagonizing the NMDA receptor may contribute to the antinociceptive effect of honey.	Flavonoids	44-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-61
17561367-5	2007	SR was more potent than syringin and isofraxidin at inhibiting the expression of IL-1beta, IL-6, cyclooxygenase (COX)-2 and matrix metalloproteinases (MMP)-1 mRNA, but was less potent than syringin at inhibiting the expression of MMP-2.	Strontium	0-2	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-119
17561367-5	2007	SR was more potent than syringin and isofraxidin at inhibiting the expression of IL-1beta, IL-6, cyclooxygenase (COX)-2 and matrix metalloproteinases (MMP)-1 mRNA, but was less potent than syringin at inhibiting the expression of MMP-2.	isofraxidin	37-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-119
18064329-9	2007	Evolutionary, this mechanism may prevent COX-2-dependent thromboxane synthesis in the platelet, which would potentiate the likelihood of thrombosis; pharmacologically, this mechanism would prevent an aspirin-insensitive pathway of thromboxane formation.	Aspirin	200-207	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-46
18064329-9	2007	Evolutionary, this mechanism may prevent COX-2-dependent thromboxane synthesis in the platelet, which would potentiate the likelihood of thrombosis; pharmacologically, this mechanism would prevent an aspirin-insensitive pathway of thromboxane formation.	Thromboxanes	231-242	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-46
18075082-7	2007	In the transformation of PCE and TCE, the formation of unidentified product(s) is most significant in Co(II)-added FeS batches.	Tetrachloroethylene	25-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-107
18075082-7	2007	In the transformation of PCE and TCE, the formation of unidentified product(s) is most significant in Co(II)-added FeS batches.	Trichloroethylene	33-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-107
18075082-7	2007	In the transformation of PCE and TCE, the formation of unidentified product(s) is most significant in Co(II)-added FeS batches.	Iron	115-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-107
17915857-4	2007	Magnetic studies show that the central Cu(dcadpz)2 motif is antiferromagnetically coupled with both the terminal Co(II) atoms via the dcadpz- ligand in 3 with a J value of -5.27 cm(-1) and ferromagnetically coupled with both the terminal Ni(II) atoms in 4 with a J value of 2.50 cm(-1), while 5 behaves only as a Curie paramagnet between 2 and 300 K due to the diamagnetic character of the central square-planar Ni(II) atom.	cu(dcadpz)2	39-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-119
17955126-2	2007	The ligand 4,4"-bipyrimidine combines a chelating bipyridine group and two terminal donor atoms into a single molecule; chelation to a single Ag(I) centre forms a square planar complex which can then form an extended planar ladder-type polymer by linking through linear Ag(I) centres whereas bis-coordination to an octahedral Co(II) centre yields a building block with four external donor nitrogen atoms which can coordinate to two distinct Ag(I) ions to form a heterometallic 2D net.	4,4'-Bipyrimidine	11-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	326-332
17915857-4	2007	Magnetic studies show that the central Cu(dcadpz)2 motif is antiferromagnetically coupled with both the terminal Co(II) atoms via the dcadpz- ligand in 3 with a J value of -5.27 cm(-1) and ferromagnetically coupled with both the terminal Ni(II) atoms in 4 with a J value of 2.50 cm(-1), while 5 behaves only as a Curie paramagnet between 2 and 300 K due to the diamagnetic character of the central square-planar Ni(II) atom.	dcadpz	42-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-119
17915857-4	2007	Magnetic studies show that the central Cu(dcadpz)2 motif is antiferromagnetically coupled with both the terminal Co(II) atoms via the dcadpz- ligand in 3 with a J value of -5.27 cm(-1) and ferromagnetically coupled with both the terminal Ni(II) atoms in 4 with a J value of 2.50 cm(-1), while 5 behaves only as a Curie paramagnet between 2 and 300 K due to the diamagnetic character of the central square-planar Ni(II) atom.	Nickel(2+)	238-244	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-119
17915857-4	2007	Magnetic studies show that the central Cu(dcadpz)2 motif is antiferromagnetically coupled with both the terminal Co(II) atoms via the dcadpz- ligand in 3 with a J value of -5.27 cm(-1) and ferromagnetically coupled with both the terminal Ni(II) atoms in 4 with a J value of 2.50 cm(-1), while 5 behaves only as a Curie paramagnet between 2 and 300 K due to the diamagnetic character of the central square-planar Ni(II) atom.	Nickel(2+)	412-418	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-119
18217608-0	2007	Co(II) and Co(III) complexes of m-benziphthalocyanine.	m-benziphthalocyanine	32-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
17943205-3	2007	The complexed amino acid was then quantitatively released into an aqueous phase, by a reductive (Co(III)--&gt; Co(II)) counter-extraction using l-ascorbic acid.	Ascorbic Acid	144-159	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	111-117
18217608-1	2007	The syntheses and structural elucidations of three different cobalt complexes of m-benziphthalocyanine are reported; both Co(II) and Co(III) complexes can be generated, and the ring undergoes partial oxidation upon metalation with Co(OAc)2x4H2O.	Cobalt	61-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-128
18217608-1	2007	The syntheses and structural elucidations of three different cobalt complexes of m-benziphthalocyanine are reported; both Co(II) and Co(III) complexes can be generated, and the ring undergoes partial oxidation upon metalation with Co(OAc)2x4H2O.	m-benziphthalocyanine	81-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-128
17950056-0	2007	A new approach for simultaneous determination of Co(II), Ni(II), Cu(II) and Pd(II) using 2-thiophenaldehyde-3-thiosemicarbazone as reagent by solid phase microextraction-high performance liquid chromatography.	2-thiophenaldehyde-3-thiosemicarbazone	89-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-55
17950056-1	2007	A new method is proposed herein for the sorption, separation and simultaneous determination of Co(II), Ni(II), Cu(II) and Pd(II) using 2-thiophenaldehyde-3-thiosemicarbazone (TPTS) as a reagent by solid phase microextraction-high performance liquid chromatography-UV detection.	2-thiophenaldehyde-3-thiosemicarbazone	135-173	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-101
17950056-1	2007	A new method is proposed herein for the sorption, separation and simultaneous determination of Co(II), Ni(II), Cu(II) and Pd(II) using 2-thiophenaldehyde-3-thiosemicarbazone (TPTS) as a reagent by solid phase microextraction-high performance liquid chromatography-UV detection.	tpts	175-179	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-101
18261308-11	2007	CONCLUSION: 4(#) siRNA effectively inhibits the expression of COX-2 mRNA and protein the level of PGE2, IL-1beta, IL-6, TNF-alpha, and VEGF in the clear supernatant of the 4(#) group is lowest.	Dinoprostone	98-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
17950056-5	2007	The detection limits for Co(II), Ni(II), Cu(II) and Pd(II) are 9, 6, 1 and 7 ng L(-1) based on 3sigma of blank response.	Polydioxanone	52-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-31
17950056-10	2007	The proposed method is tested for the determination of Co(II), Ni(II), Cu(II) and Pd(II) in alloys and water samples spiked with these metal ions.	Metals	135-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-61
17950062-5	2007	The Zn(II)-imprinted microbeads have a greater affinity for Zn(II) with respect to Cu(II), Co(II) and Ni(II) ions.	Zinc	4-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-97
17950062-5	2007	The Zn(II)-imprinted microbeads have a greater affinity for Zn(II) with respect to Cu(II), Co(II) and Ni(II) ions.	Zinc	60-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-97
17959037-1	2007	AIM: To gain insight into the histopathological responses and molecular targets in the inhibition of growth of human gastric cancer treated with celecoxib (a cyclooxygenase [COX]-2 inhibitor) combined with octreotide.	Celecoxib	145-154	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	174-180
17581270-10	2007	CONCLUSION: The COX-2 CA-haplotype is more frequently observed in patients with EAC than in patients with BE and reflux esophagitis.	Beryllium	106-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-21
17581270-11	2007	These data suggest a direct link between COX-2 activity and neoplastic progression in patients with BE and reflux esophagitis.	Beryllium	100-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-46
17567571-5	2007	In vitro studies in HPMVEC demonstrated that SU5416 suppressed PGI2S gene expression while potently inducing COX-2, VEGF, and TGF-beta1 expression; and caused transdifferentiation of mature vascular endothelial cells (defined by Dil-ac-LDL, Lectin and Factor VIII) to SM-like (as defined by expression of alpha-SM actin) "transitional" cells, coexpressing both endothelial and SM markers.	Semaxinib	45-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-114
18087590-4	2007	OBJECTIVES: Because THF-diols are derived from lipoxygenase and cyclooxygenase pathways, we suspected that these compounds may regulate cell proliferation by modulating specific enzymatic sites involved in linoleic acid metabolism including phospholipase A(2) (PLA2), lipoxygenases (LOX-5 and LOX-12), cyclooxygenases (COX-1 and COX-2), and closely coupled enzymes including aromatase (AROM).	thf-diols	20-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	329-334
18087590-4	2007	OBJECTIVES: Because THF-diols are derived from lipoxygenase and cyclooxygenase pathways, we suspected that these compounds may regulate cell proliferation by modulating specific enzymatic sites involved in linoleic acid metabolism including phospholipase A(2) (PLA2), lipoxygenases (LOX-5 and LOX-12), cyclooxygenases (COX-1 and COX-2), and closely coupled enzymes including aromatase (AROM).	Linoleic Acid	206-219	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	329-334
18087590-10	2007	DISCUSSION: THF-diol stimulation of MCF-7 cell proliferation is mediated through effects on the expression of the PLA2, COX-2, LOX-5, and LOX-12 genes and/or their respective enzyme activities.	thf-diol	12-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-125
17945363-2	2007	Cyclooxygenases-1 and -2 (COX-1 and COX-2) catalyse PG synthesis.	Prostaglandins	52-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-41
17945363-8	2007	Indeed, the influence of cAMP on COX-2 expression is complex and dependent on the cell type and cellular environment.	Cyclic AMP	25-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-38
17945363-9	2007	This review aims to summarise various topics related to cAMP-dependent COX-2 expression.	Cyclic AMP	56-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-76
17945363-12	2007	Lastly, a detailed overview of the effects of cAMP-dependent signalling on COX-2 mRNA and protein expression in various human and rodent cells is provided.	Cyclic AMP	46-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
17945363-14	2007	In this respect, the role of cAMP in the regulation of COX-2 expression, especially the human enzyme, is of significant clinical importance.	Cyclic AMP	29-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-60
18092115-0	2007	A case of takotsubo cardiomyopathy precipitated by lumiracoxib, a selective COX-2 inhibitor.	lumiracoxib	51-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-81
17953635-4	2007	This study aimed to detect tolerability of etoricoxib, a selective COX-2-inhibiting drug, in patients with chronic urticaria with a history of NSAID intolerance.	Etoricoxib	43-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-72
17953635-7	2007	The study suggests that etoricoxib, with its favourable COX-1/COX-2 ratio, is well tolerated by patients with chronic urticaria exacerbated by NSAID intolerance.	Etoricoxib	24-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
17879239-9	2007	The antioxidant vitamin C (2 mM) reduced CHP and CAA by 20-30% after 24 h of treatment, while the COX-2 inhibitor celecoxib (5 microM) had a minor effect on CHP and CAA, though it decreased the level of H2O2-induced H2AX phosphorylation and ATM activation.	Celecoxib	114-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-103
17825288-8	2007	Upregulation of iNOS and COX-2 resulted in increased production of NO and PGE(2).	Prostaglandins E	74-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-30
17825288-10	2007	Effects of LA-induced iNOS and COX-2 expression were inhibited by a NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	89-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-36
17825288-10	2007	Effects of LA-induced iNOS and COX-2 expression were inhibited by a NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	118-122	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-36
17825288-13	2007	Linoleic acid-induced expression of iNOS and COX-2 as well as PGE(2) and NO release in RPE cells were sequentially mediated through activation of p42/p44, MAPK, then NF-kappaB.	Linoleic Acid	0-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-50
17763056-1	2007	Celecoxib, a selective COX-2 inhibitor, primarily used in treatment of osteoarthritis, rheumatoid arthritis and acute pain was encapsulated in microparticles composed of various polyesters, polymethacrylates or cellulose derivatives used alone or blended.	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-28
17761345-2	2007	It has been demonstrated that celecoxib, a selective COX-2 inhibitor, can enhance apoptosis of human lupus T cells.	Celecoxib	30-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-58
17900611-9	2007	In contrast, a specific inhibitor of COX-2, NS398, significantly inhibited the lovastatin-induced expression of BK-2Rs.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	44-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-42
17900611-9	2007	In contrast, a specific inhibitor of COX-2, NS398, significantly inhibited the lovastatin-induced expression of BK-2Rs.	Lovastatin	79-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-42
17900611-10	2007	Here we show for the first time that lovastatin induces the expression of BK-2Rs in cultured human coronary artery endothelial cells through a novel cholesterol-independent pleiotropic mechanism that involves RhoA kinase inhibition and COX-2 activation.	Lovastatin	37-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	236-241
18030357-3	2007	Cyclooxygenase (Cox-2), a pro-inflammatory mediator, is a CREB target that induces prostaglandin E(2) (PGE(2)) and suppresses apoptosis.	Dinoprostone	83-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-21
17763509-8	2007	The detection limits obtained were 2 microg/L for Cu(II) and Co(II), and 1 microg/L for Ni(II) and Fe(II).	Nickel(2+)	88-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-74
17763509-8	2007	The detection limits obtained were 2 microg/L for Cu(II) and Co(II), and 1 microg/L for Ni(II) and Fe(II).	ammonium ferrous sulfate	99-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-74
18030357-3	2007	Cyclooxygenase (Cox-2), a pro-inflammatory mediator, is a CREB target that induces prostaglandin E(2) (PGE(2)) and suppresses apoptosis.	Prostaglandins E	103-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-21
17805209-7	2007	Despite a positive effect on cell proliferation with EGF, hydrocortisone blunted the stimulatory effect of EGF on COX-2 expression and PGE2 production.	Hydrocortisone	58-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-119
17317287-1	2007	Ternary Fe(III), Co(II), Ni(II), Cu(II), Zn(II) and UO(2)(II) chelates with tenoxicam (Ten) drug (H(2)L(1)) and dl-alanine (Ala) (HL(2)) and also the binary UO(2)(II) chelate with Ten were studied.	tenoxicam	76-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-23
17327142-0	2007	Spectral, IR and magnetic studies of Mn(II), Co(II), Ni(II) and Cu(II) complexes with pyrrole-2-carboxyaldehyde thiosemicarbazone (L).	pyrrole-2-carboxyaldehyde thiosemicarbazone	86-129	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-51
17327142-1	2007	Mn(II), Co(II), Ni(II) and Cu(II) complexes are synthesized with thiosemicarbazone (L) derived from pyrrole-2-carboxyaldehyde.	Thiosemicarbazones	65-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	8-14
17327142-1	2007	Mn(II), Co(II), Ni(II) and Cu(II) complexes are synthesized with thiosemicarbazone (L) derived from pyrrole-2-carboxyaldehyde.	pyrrole-2-carboxyaldehyde	100-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	8-14
17553737-1	2007	Ten novel macrocyclic Co(II) compounds have been synthesized by treating four N(4) and six N(2)O(2) donor macrocycles with cobalt chloride in methanol.	Folic Acid	78-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-28
17553737-1	2007	Ten novel macrocyclic Co(II) compounds have been synthesized by treating four N(4) and six N(2)O(2) donor macrocycles with cobalt chloride in methanol.	n(2)o(2)	91-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-28
17553737-1	2007	Ten novel macrocyclic Co(II) compounds have been synthesized by treating four N(4) and six N(2)O(2) donor macrocycles with cobalt chloride in methanol.	cobaltous chloride	123-138	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-28
17553737-1	2007	Ten novel macrocyclic Co(II) compounds have been synthesized by treating four N(4) and six N(2)O(2) donor macrocycles with cobalt chloride in methanol.	Methanol	142-150	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-28
17900108-0	2007	Uncommon ferromagnetic interactions in a homometallic Co(II) chain bridged by a single end-to-end azide.	Azides	98-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-60
17978563-6	2007	Based on the inhibition on 6-keto-PGF(1alpha) and PGE(2), the medium inhibitory concentration (IC(50)) of Cu-Asp on COX-1 and on COX-2 was 1.03+/-0.15 mM, and 0.32+/-0.04 mM, respectively.	cu-asp	106-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-134
17978563-7	2007	The selective inhibition index on COX-2, IC(50) (COX-1)/IC(50) (COX-2), of Cu-Asp was 3.33+/-0.89, while that of Asp was 0.42+/-0.12.	cu-asp	75-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-39
17978563-7	2007	The selective inhibition index on COX-2, IC(50) (COX-1)/IC(50) (COX-2), of Cu-Asp was 3.33+/-0.89, while that of Asp was 0.42+/-0.12.	cu-asp	75-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-69
17978563-7	2007	The selective inhibition index on COX-2, IC(50) (COX-1)/IC(50) (COX-2), of Cu-Asp was 3.33+/-0.89, while that of Asp was 0.42+/-0.12.	Aspirin	78-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-39
17978563-7	2007	The selective inhibition index on COX-2, IC(50) (COX-1)/IC(50) (COX-2), of Cu-Asp was 3.33+/-0.89, while that of Asp was 0.42+/-0.12.	Aspirin	78-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-69
17978563-8	2007	The results suggest that, unlike Asp, Cu-Asp is a relatively selective inhibitor of COX-2 in the present models; the selectivity of Cu-Asp is about seven-fold greater than that of Asp.	cu-asp	38-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-89
17978563-8	2007	The results suggest that, unlike Asp, Cu-Asp is a relatively selective inhibitor of COX-2 in the present models; the selectivity of Cu-Asp is about seven-fold greater than that of Asp.	Aspirin	41-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-89
17900108-2	2007	Magnetic data show that intrachain ferromagnetic couplings via the single end-to-end azide group are observed, which is an extraordinary case among the azide-bridged Co(II) systems.	Azides	85-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	166-172
17900108-2	2007	Magnetic data show that intrachain ferromagnetic couplings via the single end-to-end azide group are observed, which is an extraordinary case among the azide-bridged Co(II) systems.	Azides	152-157	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	166-172
17902645-1	2007	The binding of CoII, NiII, and CuII cations to the lithium 3-pyridinesulfonate ligand in an aqueous solution leads to single crystals of coordination polymers 1-3.	lithium 3-pyridinesulfonate	51-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-19
17902645-1	2007	The binding of CoII, NiII, and CuII cations to the lithium 3-pyridinesulfonate ligand in an aqueous solution leads to single crystals of coordination polymers 1-3.	Polymers	150-158	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-19
17707794-7	2007	Preincubation of astrocytes with GF109203X, an inhibitor of PKCs, reduces the RhoE levels and abolishes the ethanol-induced activation of IRAK, NF-kappaB and the COX-2 expression.	bisindolylmaleimide I	33-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	162-167
17707794-7	2007	Preincubation of astrocytes with GF109203X, an inhibitor of PKCs, reduces the RhoE levels and abolishes the ethanol-induced activation of IRAK, NF-kappaB and the COX-2 expression.	Ethanol	108-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	162-167
17921715-2	2007	We investigated the role of COX-2 and NF-KB expression in relation to the use of a COX-2 inhibitor (celecoxib) associated to gemcitabine and oxaliplatin in pancreatic cancer.	Celecoxib	100-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
17850144-0	2007	[CH3NH2(CH2)2NH2CH3][M2(HCOO)6] (M = MnII and CoII): weak ferromagnetic metal formate frameworks of unique binodal 6-connected (4(12).6(3))(4(9).6(6)) topology, templated by a diammonium cation.	(ch2)2nh2ch3	7-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-50
17850144-1	2007	Two compounds of [dmenH(2)(2+)][M(2)(HCOO)(6)(2-)] (M = Mn(II) and Co(II)), synthesized using N,N"-dimethylethylenediammonium (dmenH(2)(2+)) as the template, possess anionic metal formate frameworks of a novel binodal 6-connected (4(12).6(3))(4(9).6(6)) topology.	dmenh	18-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-73
17921715-2	2007	We investigated the role of COX-2 and NF-KB expression in relation to the use of a COX-2 inhibitor (celecoxib) associated to gemcitabine and oxaliplatin in pancreatic cancer.	Celecoxib	100-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
17921715-2	2007	We investigated the role of COX-2 and NF-KB expression in relation to the use of a COX-2 inhibitor (celecoxib) associated to gemcitabine and oxaliplatin in pancreatic cancer.	gemcitabine	125-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
17921715-2	2007	We investigated the role of COX-2 and NF-KB expression in relation to the use of a COX-2 inhibitor (celecoxib) associated to gemcitabine and oxaliplatin in pancreatic cancer.	gemcitabine	125-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
18038897-0	2007	Synthesis and three-dimensional qualitative structure selectivity relationship of 3,5-disubstituted-2,4-thiazolidinedione derivatives as COX2 inhibitors.	3,5-disubstituted-2,4-thiazolidinedione	82-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-141
18038897-1	2007	In our effort for synthesis of selective COX2 inhibitors, certain new 2,4-thiazolidinedione derivatives were synthesized.	2,4-thiazolidinedione	70-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-45
17786275-7	2007	COX-2 expression was demonstrated by Western blot analysis and COX-2 activity by assay of endogenous prostaglandin E2 (PGE2) production.	Dinoprostone	101-117	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
17904787-0	2007	Effects of capecitabine and vinorelbine on cell proliferation, metabolism and COX2 and p16 expression in breast cancer cell lines and solid tumour tissues.	Vinorelbine	28-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-82
17904787-12	2007	The level of COX2 and p16 after capecitabine and vinorelbine treatment was assessed with immunohistochemical methods.	Capecitabine	32-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-17
17904787-12	2007	The level of COX2 and p16 after capecitabine and vinorelbine treatment was assessed with immunohistochemical methods.	Vinorelbine	49-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-17
17387473-2	2007	EXPERIMENTAL DESIGN: Patients with squamous cell carcinoma of the head and neck preoperatively received a specific COX-2 inhibitor (rofecoxib, 25 mg daily) orally for 3 weeks.	rofecoxib	132-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-120
17408626-11	2007	RESULT(S): Ghrelin negatively affected PGs release as well as COX2, ECNOS, and INOS mRNA expressions in HUVEC.	Ghrelin	11-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-66
17764173-2	2007	Owing to benevolent line broadening and to very high sensitivities of approximately 254,000 and approximately 201,000 ppm/(unpaired electron spin) for Co(II) and Ni(II), respectively, at 298 K in these pseudotetrahedral bis(N,N"-chelates), spin transmission through the sigma- (and orthogonal pi)-bonding system of the ligands could be traced from the chelate ring over five to nine sigma bonds.	bis(n,n"-chelates)	220-238	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-157
17764174-1	2007	The complexes of the heptadentate receptor N,N"-bis(benzimidazol-2-ylmethyl)-1,10-diaza-15-crown-5 (L2) with MnII, CoII, NiII, CuII, and ZnII are reported.	n,n"-bis(benzimidazol-2-ylmethyl)-1,10-diaza-15-crown-5	43-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-119
17764174-4	2007	We have found that for the MnII, CoII, CuII, and ZnII complexes, geometry optimizations lead systematically to pentagonal-bipyramidal coordination environments around the metal ions.	Metals	171-176	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-37
17764174-7	2007	Spectrophotometric titrations carried out in dimethyl sulfoxide (DMSO) and CH3CN/DMSO (9:1) solutions indicate the following stability sequence for the complexes of L2: CoII approximately NiII &gt; ZnII &gt; MnII.	Dimethyl Sulfoxide	45-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	169-173
17764174-7	2007	Spectrophotometric titrations carried out in dimethyl sulfoxide (DMSO) and CH3CN/DMSO (9:1) solutions indicate the following stability sequence for the complexes of L2: CoII approximately NiII &gt; ZnII &gt; MnII.	Dimethyl Sulfoxide	65-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	169-173
17764174-7	2007	Spectrophotometric titrations carried out in dimethyl sulfoxide (DMSO) and CH3CN/DMSO (9:1) solutions indicate the following stability sequence for the complexes of L2: CoII approximately NiII &gt; ZnII &gt; MnII.	acetonitrile	75-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	169-173
17764174-7	2007	Spectrophotometric titrations carried out in dimethyl sulfoxide (DMSO) and CH3CN/DMSO (9:1) solutions indicate the following stability sequence for the complexes of L2: CoII approximately NiII &gt; ZnII &gt; MnII.	Dimethyl Sulfoxide	81-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	169-173
17764176-0	2007	Tripodal phenylamine-based ligands and their CoII complexes.	Aniline Compounds	9-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-49
17340600-7	2007	Responses to fluid-induced shear were blocked by the general Cox inhibitor indomethacin and the Cox-2 inhibitor meloxicam, indicating that response to shear is mediated by prostaglandin produced via a Cox-2 dependent mechanism.	Indomethacin	75-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	201-206
17340600-7	2007	Responses to fluid-induced shear were blocked by the general Cox inhibitor indomethacin and the Cox-2 inhibitor meloxicam, indicating that response to shear is mediated by prostaglandin produced via a Cox-2 dependent mechanism.	Meloxicam	112-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-101
17340600-7	2007	Responses to fluid-induced shear were blocked by the general Cox inhibitor indomethacin and the Cox-2 inhibitor meloxicam, indicating that response to shear is mediated by prostaglandin produced via a Cox-2 dependent mechanism.	Meloxicam	112-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	201-206
17340600-7	2007	Responses to fluid-induced shear were blocked by the general Cox inhibitor indomethacin and the Cox-2 inhibitor meloxicam, indicating that response to shear is mediated by prostaglandin produced via a Cox-2 dependent mechanism.	Prostaglandins	172-185	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-101
17340600-7	2007	Responses to fluid-induced shear were blocked by the general Cox inhibitor indomethacin and the Cox-2 inhibitor meloxicam, indicating that response to shear is mediated by prostaglandin produced via a Cox-2 dependent mechanism.	Prostaglandins	172-185	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	201-206
17673564-7	2007	The biosynthesis of PGE(2) was reduced between 50 and 80% (P &lt; 0.05 vs. vehicle) in the presence of either COX-1- or COX-2-selective blockers, demonstrating that both isoforms are enzymatically active.	Prostaglandins E	20-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-125
17407152-5	2007	After 24 h, the early effect of TCDD on adipocytes was predominantly on inflammation, particularly induction of COX-2 and KC (IL-8), which is accompanied by upregulation of C/EBPbeta and delta.	Polychlorinated Dibenzodioxins	32-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-124
17482353-5	2007	The sorption of Co(II) onto the prepared resins was found to follow the pseudo-second order model and the sorption rate have the values 8.79x10(-3), 10x10(-3) and 16x10(-3) g mg(-1)min(-1) for Amberlite XAD4, silica gel and wood powder, respectively.	xad4	203-207	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-22
17482353-5	2007	The sorption of Co(II) onto the prepared resins was found to follow the pseudo-second order model and the sorption rate have the values 8.79x10(-3), 10x10(-3) and 16x10(-3) g mg(-1)min(-1) for Amberlite XAD4, silica gel and wood powder, respectively.	Silica Gel	209-219	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-22
17982241-2	2007	Therefore, we investigated the role of 15-deoxy-Delta(12,14)-prostaglandinJ2 (15d-PGJ2), the natural receptor ligand for PPAR-gamma, on dedifferentiation and inflammatory responses, such as COX-2 expression and PGE2 production, in articular chondrocytes.	15-deoxy-delta(12,14)-prostaglandin J2	39-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	190-195
17982241-4	2007	15d-PGJ2 also induced COX-2 expression and PGE2 production.	15-deoxy-delta(12,14)-prostaglandin J2	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-27
17447009-0	2007	Radiosensitizing potential of the selective cyclooygenase-2 (COX-2) inhibitor meloxicam on human glioma cells.	Meloxicam	78-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-66
17447009-4	2007	In this study, the effects of the selective COX-2 inhibitor meloxicam alone and in combination with irradiation were investigated on human glioma cells in vitro.	Meloxicam	60-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-49
17447009-10	2007	The selective COX-2 inhibitor meloxicam exerted COX-2 independent growth inhibition and radiosensitization of human glioma cells.	Meloxicam	30-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
17447009-10	2007	The selective COX-2 inhibitor meloxicam exerted COX-2 independent growth inhibition and radiosensitization of human glioma cells.	Meloxicam	30-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-53
17415779-3	2007	Celecoxib, a COX-2 specific inhibitor, was by far the most potent NSAID, with an IC(50) of 39.9 +/- 1.1 microM, followed by sulindac sulfide (116.5 +/- 2.34 microM).	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
17906610-1	2007	Following the withdrawal of rofecoxib and valdecoxib, the discussion concerning selective cyclo-oxygenase (COX)-2 inhibitors was often characterized more by emotions than scientific evidence.	rofecoxib	28-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-113
18080582-10	2007	These cox inhibitors especially the cox-2 have been found to inhibit the production of prostaglandins which are necessary in bone healing.	Prostaglandins	87-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-41
17293160-0	2007	Spectrophotometric, conductometric and thermal studies of Co(II), Ni(II) and Cu(II) complexes with 2-(2-hydroxynaphthylazo)-4-hydroxy-6-methyl-1,3-pyrimidine.	cu(ii)	77-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-64
17293160-0	2007	Spectrophotometric, conductometric and thermal studies of Co(II), Ni(II) and Cu(II) complexes with 2-(2-hydroxynaphthylazo)-4-hydroxy-6-methyl-1,3-pyrimidine.	2-(2-hydroxynaphthylazo)-4-hydroxy-6-methyl-1,3-pyrimidine	99-157	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-64
17293160-7	2007	The effect of Co(II), Ni(II) and Cu(II) ions on the fluorescence of the azodye is also considered.	Azo Compounds	72-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-20
18473007-0	2007	Selective COX-2 inhibitors, NSAIDs and cardiovascular events - is celecoxib the safest choice?	Celecoxib	66-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
18473007-2	2007	In recent years concerns have arisen about the cardiovascular safety of these drugs, initially because of reported associations between therapy with the COX-2 selective inhibitor rofecoxib and myocardial infarction.	rofecoxib	179-188	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	153-158
18007088-1	2007	OBJECTIVE: To investigate the effect and mechanism of the selective COX-2 inhibitor NS-398 and carboplatin on the human cervical carcinoma cell line Hela.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	84-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-73
17635918-0	2007	Glucosamine hydrochloride specifically inhibits COX-2 by preventing COX-2 N-glycosylation and by increasing COX-2 protein turnover in a proteasome-dependent manner.	Glucosamine hydrochloride	0-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-53
17635918-0	2007	Glucosamine hydrochloride specifically inhibits COX-2 by preventing COX-2 N-glycosylation and by increasing COX-2 protein turnover in a proteasome-dependent manner.	Glucosamine hydrochloride	0-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-73
17635918-0	2007	Glucosamine hydrochloride specifically inhibits COX-2 by preventing COX-2 N-glycosylation and by increasing COX-2 protein turnover in a proteasome-dependent manner.	Glucosamine hydrochloride	0-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-73
17635918-1	2007	COX-2 and its products, including prostaglandin E(2), are involved in many inflammatory processes.	Dinoprostone	34-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
17635918-4	2007	Here we describe a new action mechanism of glucosamine hydrochloride (GS-HCl) to tackle endogenous and agonist-driven COX-2 at protein level.	Glucosamine hydrochloride	43-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-123
17635918-4	2007	Here we describe a new action mechanism of glucosamine hydrochloride (GS-HCl) to tackle endogenous and agonist-driven COX-2 at protein level.	gs-hcl	70-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-123
17635918-5	2007	GS-HCl (but not GS sulfate, N-acetyl GS, or galactosamine HCl) resulted in a shift in the molecular mass of COX-2 from 72-74 to 66-70 kDa and concomitant inhibition of prostaglandin E(2) production in a concentration-dependent manner in interleukin (IL)-1beta-treated A549 human lung epithelial cells.	gs-hcl	0-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-113
17635918-5	2007	GS-HCl (but not GS sulfate, N-acetyl GS, or galactosamine HCl) resulted in a shift in the molecular mass of COX-2 from 72-74 to 66-70 kDa and concomitant inhibition of prostaglandin E(2) production in a concentration-dependent manner in interleukin (IL)-1beta-treated A549 human lung epithelial cells.	Dinoprostone	168-186	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-113
17635918-6	2007	Remarkably, GS-HCl-mediated decrease in COX-2 molecular mass was associated with inhibition of COX-2 N-glycosylation during translation, as assessed by the effect of tunicamycin, the protein N-glycosylation inhibitor, or of cycloheximide, the translation inhibitor, on COX-2 modification.	gs-hcl	12-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
17635918-6	2007	Remarkably, GS-HCl-mediated decrease in COX-2 molecular mass was associated with inhibition of COX-2 N-glycosylation during translation, as assessed by the effect of tunicamycin, the protein N-glycosylation inhibitor, or of cycloheximide, the translation inhibitor, on COX-2 modification.	gs-hcl	12-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-100
17635918-6	2007	Remarkably, GS-HCl-mediated decrease in COX-2 molecular mass was associated with inhibition of COX-2 N-glycosylation during translation, as assessed by the effect of tunicamycin, the protein N-glycosylation inhibitor, or of cycloheximide, the translation inhibitor, on COX-2 modification.	gs-hcl	12-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-100
17635918-6	2007	Remarkably, GS-HCl-mediated decrease in COX-2 molecular mass was associated with inhibition of COX-2 N-glycosylation during translation, as assessed by the effect of tunicamycin, the protein N-glycosylation inhibitor, or of cycloheximide, the translation inhibitor, on COX-2 modification.	Cycloheximide	224-237	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
17635918-6	2007	Remarkably, GS-HCl-mediated decrease in COX-2 molecular mass was associated with inhibition of COX-2 N-glycosylation during translation, as assessed by the effect of tunicamycin, the protein N-glycosylation inhibitor, or of cycloheximide, the translation inhibitor, on COX-2 modification.	Cycloheximide	224-237	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-100
17635918-6	2007	Remarkably, GS-HCl-mediated decrease in COX-2 molecular mass was associated with inhibition of COX-2 N-glycosylation during translation, as assessed by the effect of tunicamycin, the protein N-glycosylation inhibitor, or of cycloheximide, the translation inhibitor, on COX-2 modification.	Cycloheximide	224-237	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-100
17635918-7	2007	Specifically, the effect of low concentration of GS-HCl (1 mM) or of tunicamycin (0.1 microg/ml) to produce the aglycosylated COX-2 was rescued by the proteasomal inhibitor MG132 but not by the lysosomal or caspase inhibitors.	gs-hcl	49-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-131
17635918-7	2007	Specifically, the effect of low concentration of GS-HCl (1 mM) or of tunicamycin (0.1 microg/ml) to produce the aglycosylated COX-2 was rescued by the proteasomal inhibitor MG132 but not by the lysosomal or caspase inhibitors.	Tunicamycin	69-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-131
17635918-7	2007	Specifically, the effect of low concentration of GS-HCl (1 mM) or of tunicamycin (0.1 microg/ml) to produce the aglycosylated COX-2 was rescued by the proteasomal inhibitor MG132 but not by the lysosomal or caspase inhibitors.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	173-178	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-131
17635918-9	2007	Notably, GS-HCl (5 mM) also facilitated degradation of the higher molecular species of COX-2 in IL-1beta-treated A549 cells that was retarded by MG132.	gs-hcl	9-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-92
17635918-9	2007	Notably, GS-HCl (5 mM) also facilitated degradation of the higher molecular species of COX-2 in IL-1beta-treated A549 cells that was retarded by MG132.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	145-150	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-92
17635918-10	2007	GS-HCl (5 mM) was also able to decrease the molecular mass of endogenous and IL-1beta- or tumor necrosis factor-alpha-driven COX-2 in different human cell lines, including Hep2 (bronchial) and H292 (laryngeal).	gs-hcl	0-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-130
17604631-1	2007	Resveratrol ((E)-3,4",5-trihydroxy-stilbene), a phytoalexin found in various plants, shows non-selective cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) inhibition.	Resveratrol	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-157
17604631-1	2007	Resveratrol ((E)-3,4",5-trihydroxy-stilbene), a phytoalexin found in various plants, shows non-selective cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) inhibition.	Resveratrol	13-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-157
17604631-2	2007	In order to find more selective COX inhibitors a series of bridged stilbene derivatives was synthesized and evaluated for their ability to inhibit both COX-1 and COX-2 in vitro.	Stilbenes	67-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	162-167
17948784-3	2007	Fe(II), Co(II), Ni(II), and Hg(II) were evaluated for their impact on the dechlorination rates of PCE and TCE by FeS.	Tetrachloroethylene	98-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	8-14
17948784-3	2007	Fe(II), Co(II), Ni(II), and Hg(II) were evaluated for their impact on the dechlorination rates of PCE and TCE by FeS.	Trichloroethylene	106-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	8-14
17948784-3	2007	Fe(II), Co(II), Ni(II), and Hg(II) were evaluated for their impact on the dechlorination rates of PCE and TCE by FeS.	Iron	113-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	8-14
17948784-5	2007	Relative to 0.01 M Fe(II)-added FeS batches, the dechlorination rates increased in FeS batches amended with 0.01 M of Co(II) and Hg(II), whereas the rates decreased in 0.01 M Ni(II)-added batches.	ammonium ferrous sulfate	19-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-124
17948784-5	2007	Relative to 0.01 M Fe(II)-added FeS batches, the dechlorination rates increased in FeS batches amended with 0.01 M of Co(II) and Hg(II), whereas the rates decreased in 0.01 M Ni(II)-added batches.	Iron	83-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-124
17640617-25	2007	We have identified a tripeptide inhibitor which is a potential lead for a new class of COX-2 inhibitor.	tripeptide K-26	21-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-92
17696334-4	2007	The model compound for the study is the nonsteroidal anti-inflammatory drug celecoxib, a COX-2 selective inhibitor and known CYP2C9 substrate.	Celecoxib	76-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-94
17724132-0	2007	COX-2 suppresses tissue factor expression via endocannabinoid-directed PPARdelta activation.	Endocannabinoids	46-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
17724132-3	2007	We show that the metabolism of endocannabinoids by the endothelial cell COX-2 coupled to the prostacyclin (PGI(2)) synthase (PGIS) activates the nuclear receptor peroxisomal proliferator-activated receptor (PPAR) delta, which negatively regulates the expression of tissue factor (TF), the primary initiator of blood coagulation.	Endocannabinoids	31-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
17786211-6	2007	Trends in inpatient stay due to MI were tightly coupled to the rise and fall of prescriptions of COX-2 inhibitors, with an 18.5% increase in inpatient stays for MI when both rofecoxib and celecoxib were on the market (P&lt;0.001).	rofecoxib	174-183	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
17786211-6	2007	Trends in inpatient stay due to MI were tightly coupled to the rise and fall of prescriptions of COX-2 inhibitors, with an 18.5% increase in inpatient stays for MI when both rofecoxib and celecoxib were on the market (P&lt;0.001).	Celecoxib	188-197	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
18390065-0	2007	Novel determination of nabumetone, a cox-2 inhibitor precursor via its 4-carboxyl-2,6-dinitrobenzene diazonium (CDNBD) derived AZO dye.	Nabumetone	23-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-42
18390065-0	2007	Novel determination of nabumetone, a cox-2 inhibitor precursor via its 4-carboxyl-2,6-dinitrobenzene diazonium (CDNBD) derived AZO dye.	4-carboxyl-2,6-dinitrobenzene diazonium	71-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-42
18390065-0	2007	Novel determination of nabumetone, a cox-2 inhibitor precursor via its 4-carboxyl-2,6-dinitrobenzene diazonium (CDNBD) derived AZO dye.	cdnbd	112-117	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-42
18390065-0	2007	Novel determination of nabumetone, a cox-2 inhibitor precursor via its 4-carboxyl-2,6-dinitrobenzene diazonium (CDNBD) derived AZO dye.	Azo Compounds	127-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-42
18034968-11	2007	Several studies have indicated that selective COX-2 inhibitors can be safely administered in patients with aspirin-exacerbated respiratory disease and NSAID-induced cutaneous reactions, although their use has been curtailed by their cardiovascular side effects.	Aspirin	107-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
17643350-0	2007	Characterization of prostaglandin E2 generation through the cyclooxygenase (COX)-2 pathway in human neutrophils.	Dinoprostone	20-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-82
17643350-2	2007	We found that the Ca2+-dependent type IV cytosolic phospholipase A2 (cPLA2) was pivotally involved in the COX-2-mediated generation of PGE2 in response to a calcium ionophore, as determined by the use of selected PLA2 inhibitors.	Dinoprostone	135-139	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-111
17643350-2	2007	We found that the Ca2+-dependent type IV cytosolic phospholipase A2 (cPLA2) was pivotally involved in the COX-2-mediated generation of PGE2 in response to a calcium ionophore, as determined by the use of selected PLA2 inhibitors.	Calcium	157-164	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-111
18424914-2	2007	We previously reported that both the selective COX-1 inhibitor SC-560 and the selective COX-2 inhibitor CAY10404 exhibit anti-tumor effects in human hepatoma cells.	3-(4-methylsulfonylphenyl)-4-phenyl-5-trifluoromethylisoxazole	104-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-93
18424914-5	2007	Treatment of hepatoma cells with the selective COX-1 inhibitor SC-560, as well as with the selective COX-2 inhibitor CAY10404, was associated with activation of ERK1/2 in a time- and dose-dependent manner.	3-(4-methylsulfonylphenyl)-4-phenyl-5-trifluoromethylisoxazole	117-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-106
18424914-6	2007	Treatment with COX-1 and COX-2 inhibitors in the presence of the selective MEK1/2 inhibitor U0126 effectively suppressed ERK1/2 activation and combinations of either SC-560 or CAY10404 with U0126 resulted in synergistic effects on cell growth inhibition and induction of apoptosis.	U 0126	92-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-30
18424914-6	2007	Treatment with COX-1 and COX-2 inhibitors in the presence of the selective MEK1/2 inhibitor U0126 effectively suppressed ERK1/2 activation and combinations of either SC-560 or CAY10404 with U0126 resulted in synergistic effects on cell growth inhibition and induction of apoptosis.	3-(4-methylsulfonylphenyl)-4-phenyl-5-trifluoromethylisoxazole	176-184	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-30
18424914-6	2007	Treatment with COX-1 and COX-2 inhibitors in the presence of the selective MEK1/2 inhibitor U0126 effectively suppressed ERK1/2 activation and combinations of either SC-560 or CAY10404 with U0126 resulted in synergistic effects on cell growth inhibition and induction of apoptosis.	U 0126	190-195	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-30
17786275-11	2007	Furthermore, the rate of apoptosis induced by hecogenin or tigogenin was associated with overexpression of COX-2 correlated with overproduction of endogenous PGE2.	Dinoprostone	158-162	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-112
18062235-6	2007	COS also inhibited the expression of TPA-induced COX-2 protein in HT-29 cells.	carbonyl sulfide	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-54
19804301-5	2007	His work linked COX-2 inhibitors such as Celebrex and Vioxx (Merck, NJ, USA) with heart attacks, and prevented Merck"s similar product, Arcoxia, from being approved.	Celecoxib	41-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-21
19804301-5	2007	His work linked COX-2 inhibitors such as Celebrex and Vioxx (Merck, NJ, USA) with heart attacks, and prevented Merck"s similar product, Arcoxia, from being approved.	rofecoxib	54-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-21
17671737-5	2007	RT-PCR evaluations performed in MCF-7 and MCF-7R showed that curcumin or MR 39 produced early modifications in the amounts of relevant gene transcripts, which, however, were mostly diverse (i.e. represented by decreases in IAPs and COX-2 in MCF-7R versus reductions in Bcl-2 and Bcl-XL as well as increases in the Bcl-XS/Bcl-XL ratio in MCF-7) in the two cell lines.	Curcumin	61-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	232-237
17671742-6	2007	Furthermore, curcumin decreased the expression levels of the cyclooxygenase (COX)-2 mRNA and protein without causing significant changes in the COX-1 levels, which was correlated with the inhibition of prostaglandin E(2) synthesis.	Curcumin	13-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-83
17720067-6	2007	In addition, COX-1 (homeostatic) and COX-2 (inducible) inhibitory activities of nepafenac, amfenac, ketorolac, and bromfenac were determined via the in vitro measurement of prostaglandin E(2) (PGE(2)) inhibition.	nepafenac	80-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-42
17720067-6	2007	In addition, COX-1 (homeostatic) and COX-2 (inducible) inhibitory activities of nepafenac, amfenac, ketorolac, and bromfenac were determined via the in vitro measurement of prostaglandin E(2) (PGE(2)) inhibition.	bromfenac	115-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-42
17720067-12	2007	Ketorolac showed the most potent COX-1 inhibition, whereas amfenac was the most potent COX-2 inhibitor.	amfenac	59-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-92
17720067-14	2007	CONCLUSION: Nepafenac showed significantly greater ocular bioavailability and amfenac demonstrated greater potency at COX-2 inhibition than ketorolac or bromfenac.	amfenac	78-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-123
17531245-0	2007	Preparation, characterization, and CuX2 and CoX2 (X=Cl-, Br-, ClO-4) adsorption behavior of a polyhedral oligomer silsesquioxane functionalized with an organic base.	perchlorate	62-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-48
17531245-0	2007	Preparation, characterization, and CuX2 and CoX2 (X=Cl-, Br-, ClO-4) adsorption behavior of a polyhedral oligomer silsesquioxane functionalized with an organic base.	silsesquioxane	114-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-48
17531245-2	2007	The isotherms of adsorption of MX(2) (M=Cu(II), Co(II); X=Cl(-), Br(-), ClO(-)(4)) by ATPS were studied in ethanol and aqueous solutions at 298 K. The results showed that there is a good fit between the experimental data and the Langmuir isotherm.	morpholinoanthracycline MX2	31-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-54
17531245-2	2007	The isotherms of adsorption of MX(2) (M=Cu(II), Co(II); X=Cl(-), Br(-), ClO(-)(4)) by ATPS were studied in ethanol and aqueous solutions at 298 K. The results showed that there is a good fit between the experimental data and the Langmuir isotherm.	atps	86-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-54
17531245-3	2007	The adsorption capacity in both solvents followed the sequence Cu(II)&gt;&gt;Co(II).	cu(ii)	63-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-83
17887937-3	2007	Prostaglandin E2 generation was inhibited by the mixed extract in human osteosarcoma cells expressing COX-2, while leukotriene production was inhibited in both human cell lines, immortalized THP-1 monocyte and HT-29 colorectal adenocarcinoma.	Dinoprostone	0-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-107
17368882-5	2007	After 1 h, the genistein-treated cells were stimulated by 1 microg/ml LPS for 24 h. Cells were then harvested, and the cytosolic fraction was isolated for assessment of COX-1 and COX-2 protein levels using Western analysis.	Genistein	15-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	179-184
17368882-9	2007	Our data indicate that the LPS-stimulated increases in COX-2 protein level and NO in supernatant are reduced by pretreatment of genistein, whereas COX-1 protein level is not affected by genistein.	Genistein	128-137	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-60
17368882-10	2007	The ability of genistein to suppress COX-2 but not COX-1 is advantageous because suppressing COX-2 can lead to suppression of proinflammatory molecules.	Genistein	15-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-42
18062235-6	2007	COS also inhibited the expression of TPA-induced COX-2 protein in HT-29 cells.	Tetradecanoylphorbol Acetate	37-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-54
17924829-2	2007	This study evaluated associations between the clinical requirement for LTRA and genetic polymorphisms of the ALOX5, LTC4S, COX-2, CysLTR1 and TBXA2R genes in the arachidonic acid cascade in the long-term management of 89 AIA patients from a Korean population.	Arachidonic Acid	162-178	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-128
17368882-10	2007	The ability of genistein to suppress COX-2 but not COX-1 is advantageous because suppressing COX-2 can lead to suppression of proinflammatory molecules.	Genistein	15-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-98
17368882-11	2007	Although genistein suppresses COX-2 production, it does not affect the production of COX-1 enzyme, which is responsible for releasing prostaglandins involved in cellular house-keeping functions such as the maintenance of gastrointestinal integrity and vascular homeostasis.	Genistein	9-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-35
17541796-5	2007	This clinical outcome was supported by the existence of plausible eicosanoid-based biological mechanisms whereby selective COX-2 inhibition could increase CV risk.	Eicosanoids	66-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-128
17768713-0	2007	Oxidation and chemiluminescence of catechol by hydrogen peroxide in the presence of Co(II) ions and CTAB micelles.	catechol	35-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-90
17768713-0	2007	Oxidation and chemiluminescence of catechol by hydrogen peroxide in the presence of Co(II) ions and CTAB micelles.	Hydrogen Peroxide	47-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-90
17768713-1	2007	The oxidation of catechol in neutral and slightly alkaline aqueous solutions (pH 7-9.6) by excess hydrogen peroxide (0.002-0.09 mol/L) in the presence of Co(II) (2.10(-7)-2.10(-5) mol/L) is accompanied by abrupt formation of red purple colouration, which is subsequently decolourized within 1 h. The electron spectra of the reaction mixture are characterized by a broad band covering the whole visible range (400-700 nm), with maximum at 485 nm.	catechol	17-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	154-160
17768713-1	2007	The oxidation of catechol in neutral and slightly alkaline aqueous solutions (pH 7-9.6) by excess hydrogen peroxide (0.002-0.09 mol/L) in the presence of Co(II) (2.10(-7)-2.10(-5) mol/L) is accompanied by abrupt formation of red purple colouration, which is subsequently decolourized within 1 h. The electron spectra of the reaction mixture are characterized by a broad band covering the whole visible range (400-700 nm), with maximum at 485 nm.	Hydrogen Peroxide	98-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	154-160
17675106-11	2007	Taken together, we conclude that therapeutic use of NS-398 in the treatment of oxidative stress-oriented neuronal disorders would be beneficial through dual actions: HO-1 induction and COX-2 inhibition.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	52-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	185-190
17878511-3	2007	PGE(2) is formed from arachidonic acid by cyclooxygenase (COX-1 and COX-2)-catalyzed formation of prostaglandin H(2) (PGH(2)) and further transformation by PGE synthases.	Prostaglandins E	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-73
17878511-3	2007	PGE(2) is formed from arachidonic acid by cyclooxygenase (COX-1 and COX-2)-catalyzed formation of prostaglandin H(2) (PGH(2)) and further transformation by PGE synthases.	Arachidonic Acid	22-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-73
17878511-3	2007	PGE(2) is formed from arachidonic acid by cyclooxygenase (COX-1 and COX-2)-catalyzed formation of prostaglandin H(2) (PGH(2)) and further transformation by PGE synthases.	Prostaglandin H2	98-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-73
17878511-3	2007	PGE(2) is formed from arachidonic acid by cyclooxygenase (COX-1 and COX-2)-catalyzed formation of prostaglandin H(2) (PGH(2)) and further transformation by PGE synthases.	GH2 protein, human	118-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-73
17878511-7	2007	cPGES uses PGH(2) produced by COX-1 whereas mPGES-1 uses COX-2-derived endoperoxide.	endoperoxide	71-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-62
17321791-7	2007	Within the studied solids, the most intense and broad metal-to-metal charge transfer bands were found for a series of low spin Co(III) high spin Co(II) hexacyanoferrates(II,III) and with similar features also for ferric ferrocyanide (Prussian blue), assigned to Fe(II)--&gt;Co(III) and Fe(II)--&gt;Fe(III) photo-induced transition, respectively.	ferric ferrocyanide	234-248	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-151
17880512-6	2007	In contrast, application of SC-560 and rofecoxib, specific inhibitors of COX-1 and COX-2, respectively, attenuated PDT.	SC 560	28-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
17880512-6	2007	In contrast, application of SC-560 and rofecoxib, specific inhibitors of COX-1 and COX-2, respectively, attenuated PDT.	rofecoxib	39-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
17321791-7	2007	Within the studied solids, the most intense and broad metal-to-metal charge transfer bands were found for a series of low spin Co(III) high spin Co(II) hexacyanoferrates(II,III) and with similar features also for ferric ferrocyanide (Prussian blue), assigned to Fe(II)--&gt;Co(III) and Fe(II)--&gt;Fe(III) photo-induced transition, respectively.	ammonium ferrous sulfate	262-268	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-151
17321791-7	2007	Within the studied solids, the most intense and broad metal-to-metal charge transfer bands were found for a series of low spin Co(III) high spin Co(II) hexacyanoferrates(II,III) and with similar features also for ferric ferrocyanide (Prussian blue), assigned to Fe(II)--&gt;Co(III) and Fe(II)--&gt;Fe(III) photo-induced transition, respectively.	ammonium ferrous sulfate	286-292	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-151
17435173-7	2007	COX inhibition correlated with MAA plasma levels (ex vivo IC50 values of 1.03 micromol/L [COX-1] and 0.87 micromol/L [COX-2]).	noramidopyrine	31-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-123
21122290-1	2007	BACKGROUND: Recent studies have shown that NS-398, a highly selective COX-2 inhibitor, can enhance the inhibition effects of cisplatin on adenocarcinoma cell proliferation, but the mechanism is still unknown.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	43-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-75
21122290-1	2007	BACKGROUND: Recent studies have shown that NS-398, a highly selective COX-2 inhibitor, can enhance the inhibition effects of cisplatin on adenocarcinoma cell proliferation, but the mechanism is still unknown.	Cisplatin	125-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-75
17640567-5	2007	The reducing agent also counteracted the inhibitory effects of curcumin on TNF-induced NF-kappaB-regulated antiapoptotic (Bcl-2, Bcl-xL, IAP1), proliferative (cyclin D1), and proinflammatory (COX-2, iNOS, and MMP-9) gene products.	Curcumin	63-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	192-197
17618045-5	2007	The COX-2 inhibitor NS 398 blocked the effects of acid and leptin but while both acid and leptin individually significantly increased PGE2 production and COX-2 mRNA levels, the combination was not more effective than either stimulant alone.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	20-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
17685888-0	2007	Clinical pharmacology of celecoxib, a COX-2 selective inhibitor.	Celecoxib	25-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-43
17685888-3	2007	Celecoxib was the first COX-2 inhibitor introduced on the market, and it still remains so, whereas rofecoxib and valdecoxib were withdrawn due to excess cardiovascular (CV) risk.	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
17685888-7	2007	in short-treatment, especially in patients with previous experience of GI events and the recommendation of avoiding use of celecoxib in patients with CV history or risk, contribute in the decision-making process of prescribing COX-2 or NSAIDs.	Celecoxib	123-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	227-232
17435173-11	2007	Given the profound COX-2 suppression by dipyrone, which was considerably above COX-2 inhibition by single analgesic doses of celecoxib and rofecoxib, a significant portion of its analgesic action may be ascribed to peripheral mechanisms.	Dipyrone	40-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-24
17925765-1	2007	Drug-induced pancreatitis injury due to celecoxib, a first generation Cox-2 inhibitor, has been rarely reported.	Celecoxib	40-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-75
17321788-0	2007	Spectral and thermal studies of solid-phase thermochromism of Co(II) double metal complexes.	Metals	76-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-68
17321791-2	2007	In cobalticyanides the observed signals were assigned to a metal-to-ligand charge transfer, which appears as a shoulder below 450 nm, and to d-d transitions for Co(II), Ni(II) and Cu(II) complex salts.	cobalticyanides	3-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	161-167
17901590-9	2007	In OE-19 cells, the COX-2 expression was detected and significantly increased by the addition of TNFalpha into the medium, however, this effect was significantly attenuated by simvastatin.	Simvastatin	176-187	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-25
17321791-2	2007	In cobalticyanides the observed signals were assigned to a metal-to-ligand charge transfer, which appears as a shoulder below 450 nm, and to d-d transitions for Co(II), Ni(II) and Cu(II) complex salts.	cu(ii)	180-186	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	161-167
17321791-7	2007	Within the studied solids, the most intense and broad metal-to-metal charge transfer bands were found for a series of low spin Co(III) high spin Co(II) hexacyanoferrates(II,III) and with similar features also for ferric ferrocyanide (Prussian blue), assigned to Fe(II)--&gt;Co(III) and Fe(II)--&gt;Fe(III) photo-induced transition, respectively.	Metals	54-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-151
17321791-7	2007	Within the studied solids, the most intense and broad metal-to-metal charge transfer bands were found for a series of low spin Co(III) high spin Co(II) hexacyanoferrates(II,III) and with similar features also for ferric ferrocyanide (Prussian blue), assigned to Fe(II)--&gt;Co(III) and Fe(II)--&gt;Fe(III) photo-induced transition, respectively.	Metals	63-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-151
17321791-7	2007	Within the studied solids, the most intense and broad metal-to-metal charge transfer bands were found for a series of low spin Co(III) high spin Co(II) hexacyanoferrates(II,III) and with similar features also for ferric ferrocyanide (Prussian blue), assigned to Fe(II)--&gt;Co(III) and Fe(II)--&gt;Fe(III) photo-induced transition, respectively.	ferric ferrocyanide	213-232	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-151
17570005-0	2007	Conjugated linoleic acids can change phagocytosis of human monocytes/macrophages by reduction in Cox-2 expression.	Linoleic Acids	11-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
17616393-10	2007	The small molecule drug design approach focuses on the synthesis and biological evaluation of a novel series of sulfonanilide analogs derived from the COX-2 selective inhibitors.	sulfonanilide	112-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-156
17570005-7	2007	The inhibition of mRNA Cox-2 expression contributed (particularly with respect to trans-10, cis-12 CLA) to a decrease in protein Cox-2 synthesis and to reduction of prostaglandin E2 content in the cell.	Dinoprostone	165-181	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-28
17222507-0	2007	Determination of Co(II) in water and soil samples using spectrophotometry coupled with preconcentration on 4-amino methyl pyridine anchored silica gel column.	Water	27-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-23
17546626-3	2007	On the other hand, 15-hydroxy-prostaglandin dehydrogenase (15-PGDH), which is involved in the degradation pathway of PG including PGE(2,) thus counteracting the activities of COX-2 and PGES, was found to be downregulated in human epithelial tumors, indicating a tumor suppressor activity of this enzyme.	Prostaglandins	62-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	175-180
17546626-3	2007	On the other hand, 15-hydroxy-prostaglandin dehydrogenase (15-PGDH), which is involved in the degradation pathway of PG including PGE(2,) thus counteracting the activities of COX-2 and PGES, was found to be downregulated in human epithelial tumors, indicating a tumor suppressor activity of this enzyme.	Prostaglandins E	130-133	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	175-180
17070098-5	2007	Activation of AKT by 1.7-fold and up-regulation of COX-2 by 2-fold were elicited following ANE treatment in NHOK.	ane	91-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-56
17654308-6	2007	However, our data do not exclude the possibility that in subjects at risk for atherothrombotic complications (e.g. patients with advanced atherosclerotic disease) COX-2 inhibitors may result in platelet activation by inhibiting endothelial prostacyclin formation.	Epoprostenol	240-252	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	163-168
17600148-0	2007	Cleavage of recombinant proteins at poly-His sequences by Co(II) and Cu(II).	poly-his	36-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-64
17613921-5	2007	RESULTS: The semi-selective NSAIDs (nimesulide, nabumetone, meloxicam, etodolac) had the highest odds ratio for upper GI events even after adjusting for various potential confounders (adjusted odds ratio (AOR) 3.63; 95% CI 3.08-4.28), followed by non-selective (2.98; 2.70-3.29) and COX-2 selective NSAIDs (2.53; 2.09-3.07).	nimesulide	36-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	283-288
17613921-5	2007	RESULTS: The semi-selective NSAIDs (nimesulide, nabumetone, meloxicam, etodolac) had the highest odds ratio for upper GI events even after adjusting for various potential confounders (adjusted odds ratio (AOR) 3.63; 95% CI 3.08-4.28), followed by non-selective (2.98; 2.70-3.29) and COX-2 selective NSAIDs (2.53; 2.09-3.07).	Etodolac	71-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	283-288
17222507-0	2007	Determination of Co(II) in water and soil samples using spectrophotometry coupled with preconcentration on 4-amino methyl pyridine anchored silica gel column.	4-pyridylmethylamine	107-130	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-23
17222507-0	2007	Determination of Co(II) in water and soil samples using spectrophotometry coupled with preconcentration on 4-amino methyl pyridine anchored silica gel column.	Silicon Dioxide	140-146	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-23
17222507-1	2007	4-amino methyl pyridine anchored silica gel (4-AMPS) was used as a sorbent in a simple sensitive spectrophotometry determination of Co(II) in various samples using piperazine dithiocarbamate as a color developing agent (lambda(max)=390 nm) at pH 5.0+/-0.2.	4-pyridylmethylamine	0-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-138
17222507-1	2007	4-amino methyl pyridine anchored silica gel (4-AMPS) was used as a sorbent in a simple sensitive spectrophotometry determination of Co(II) in various samples using piperazine dithiocarbamate as a color developing agent (lambda(max)=390 nm) at pH 5.0+/-0.2.	Silica Gel	33-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-138
17222507-1	2007	4-amino methyl pyridine anchored silica gel (4-AMPS) was used as a sorbent in a simple sensitive spectrophotometry determination of Co(II) in various samples using piperazine dithiocarbamate as a color developing agent (lambda(max)=390 nm) at pH 5.0+/-0.2.	4-amps	45-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-138
17222507-1	2007	4-amino methyl pyridine anchored silica gel (4-AMPS) was used as a sorbent in a simple sensitive spectrophotometry determination of Co(II) in various samples using piperazine dithiocarbamate as a color developing agent (lambda(max)=390 nm) at pH 5.0+/-0.2.	piperazine dithiocarbamate	164-190	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-138
17222507-7	2007	The present method was successfully applied for the determination of Co(II) in various water and soil samples.	Water	87-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-75
17290397-13	2007	Our results imply that both prostaglandin production (COX-2) and signaling via EP(1-4) subtype receptors, particularly EP(2), predict disease-specific mortality in colorectal cancer.	Prostaglandins	28-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-59
17564434-1	2007	The properties of Cu(II) and Co(II) complexes with oxygen- or nitrogen-containing macrocycles have been extensively studied; however, less attention has been paid to the study of complexes containing sulfur atoms in the first coordination sphere.	Oxygen	51-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-35
17564434-1	2007	The properties of Cu(II) and Co(II) complexes with oxygen- or nitrogen-containing macrocycles have been extensively studied; however, less attention has been paid to the study of complexes containing sulfur atoms in the first coordination sphere.	Nitrogen	62-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-35
18536160-1	2007	The complexes of Co(II), Ni(II) and Cu(II) with N,N"-bis-[5-X-salicylidene]-4,4"-diaminodibenzyl, abbreviated as H2-XSalPDADB (X = -H, -CH3, -Br) have been synthesized and investigated by elemental analysis, electrical conductance, magnetic, spectral and thermal studies.	n,n"-bis-[5-x-salicylidene]-4,4"-diaminodibenzyl	48-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-23
18536160-1	2007	The complexes of Co(II), Ni(II) and Cu(II) with N,N"-bis-[5-X-salicylidene]-4,4"-diaminodibenzyl, abbreviated as H2-XSalPDADB (X = -H, -CH3, -Br) have been synthesized and investigated by elemental analysis, electrical conductance, magnetic, spectral and thermal studies.	h2-xsalpdadb	113-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-23
17609236-12	2007	COX-2 selective NSAIDs, especially in patients with aspirin-induced asthma, have not been found to cross-react.	Aspirin	52-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
17695530-5	2007	RESULTS: For the first time, it was demonstrated that licofelone inhibited prostate cancer cell growth and significantly down-regulated COX-2 and 5-LOX expression.	licofelone	54-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	136-147
17661262-1	2007	Concerning the current discussion about cardiovascular toxicity of the selective COX-2 inhibitors, recently advertised in the media as a new milestone in the management of pain, culminating in the market withdrawal of the preparations Vioxx (rofecoxib) in 2004 and Bextra (valdecoxib) in 2005, the classical NSAIDs are now spotlighted.	rofecoxib	235-240	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-86
17661262-1	2007	Concerning the current discussion about cardiovascular toxicity of the selective COX-2 inhibitors, recently advertised in the media as a new milestone in the management of pain, culminating in the market withdrawal of the preparations Vioxx (rofecoxib) in 2004 and Bextra (valdecoxib) in 2005, the classical NSAIDs are now spotlighted.	rofecoxib	242-251	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-86
17661262-1	2007	Concerning the current discussion about cardiovascular toxicity of the selective COX-2 inhibitors, recently advertised in the media as a new milestone in the management of pain, culminating in the market withdrawal of the preparations Vioxx (rofecoxib) in 2004 and Bextra (valdecoxib) in 2005, the classical NSAIDs are now spotlighted.	valdecoxib	265-271	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-86
17661262-1	2007	Concerning the current discussion about cardiovascular toxicity of the selective COX-2 inhibitors, recently advertised in the media as a new milestone in the management of pain, culminating in the market withdrawal of the preparations Vioxx (rofecoxib) in 2004 and Bextra (valdecoxib) in 2005, the classical NSAIDs are now spotlighted.	valdecoxib	273-283	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-86
17695530-7	2007	CONCLUSION: Licofelone inhibited COX-2 and 5-LOX simultaneously and prevented overall cancer cell growth by enhancing apoptosis in both androgen-dependent and androgen-independent prostate cancer cells.	licofelone	12-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-44
17556027-10	2007	The co-administration of acetylsalicylic acid appears to reduce the GI safety of COX-2s in subgroup analyses.	Aspirin	25-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-86
17603188-0	2007	Two new Co(II) and Ni(II) complexes with 3-(2-Pyridyl)pyrazole-based ligand: synthesis, crystal structures, and bioactivities.	2-(1H-Pyrazol-3-Yl)Pyridine	41-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	8-14
17603188-1	2007	Two new Co(II) and Ni(II) complexes exhibiting DNA cytotoxic activities with 3-(2-pyridyl)pyrazole-based ligand, [Co(L)(3)](ClO(4))(2) (1) and [Ni(L)(3)](ClO(4))(2) (2) (L=1-[3-(2-pyridyl)-pyrazol-1-ylmethyl]-naphthalene) were synthesized and structurally characterized.	2-(1H-Pyrazol-3-Yl)Pyridine	77-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	8-14
17603188-1	2007	Two new Co(II) and Ni(II) complexes exhibiting DNA cytotoxic activities with 3-(2-pyridyl)pyrazole-based ligand, [Co(L)(3)](ClO(4))(2) (1) and [Ni(L)(3)](ClO(4))(2) (2) (L=1-[3-(2-pyridyl)-pyrazol-1-ylmethyl]-naphthalene) were synthesized and structurally characterized.	tetracycline CMT-3	114-122	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	8-14
17603188-1	2007	Two new Co(II) and Ni(II) complexes exhibiting DNA cytotoxic activities with 3-(2-pyridyl)pyrazole-based ligand, [Co(L)(3)](ClO(4))(2) (1) and [Ni(L)(3)](ClO(4))(2) (2) (L=1-[3-(2-pyridyl)-pyrazol-1-ylmethyl]-naphthalene) were synthesized and structurally characterized.	clo	124-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	8-14
17603188-1	2007	Two new Co(II) and Ni(II) complexes exhibiting DNA cytotoxic activities with 3-(2-pyridyl)pyrazole-based ligand, [Co(L)(3)](ClO(4))(2) (1) and [Ni(L)(3)](ClO(4))(2) (2) (L=1-[3-(2-pyridyl)-pyrazol-1-ylmethyl]-naphthalene) were synthesized and structurally characterized.	ni(l)(3)](clo(4))	144-161	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	8-14
17556027-12	2007	The co-administration of acetylsalicylic acid might reduce the safety advantage of COX-2s over that of nonselective NSAIDs.	Aspirin	25-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
17603188-1	2007	Two new Co(II) and Ni(II) complexes exhibiting DNA cytotoxic activities with 3-(2-pyridyl)pyrazole-based ligand, [Co(L)(3)](ClO(4))(2) (1) and [Ni(L)(3)](ClO(4))(2) (2) (L=1-[3-(2-pyridyl)-pyrazol-1-ylmethyl]-naphthalene) were synthesized and structurally characterized.	1-(3-(2-pyridyl)pyrazol-1-ylmethyl)naphthalene	172-220	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	8-14
17659482-4	2007	Another agent, the endocannabinoid anandamide has been demonstrated to be effectively converted by cyclooxygenase COX-2 into prostamide, a new class of fatty acid amide, in which the C1-terminus is an ethanolamide.	Endocannabinoids	19-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-119
17659482-4	2007	Another agent, the endocannabinoid anandamide has been demonstrated to be effectively converted by cyclooxygenase COX-2 into prostamide, a new class of fatty acid amide, in which the C1-terminus is an ethanolamide.	anandamide	35-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-119
17659482-4	2007	Another agent, the endocannabinoid anandamide has been demonstrated to be effectively converted by cyclooxygenase COX-2 into prostamide, a new class of fatty acid amide, in which the C1-terminus is an ethanolamide.	Bimatoprost	125-135	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-119
17659482-4	2007	Another agent, the endocannabinoid anandamide has been demonstrated to be effectively converted by cyclooxygenase COX-2 into prostamide, a new class of fatty acid amide, in which the C1-terminus is an ethanolamide.	fatty acid amide	152-168	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-119
17393325-2	2007	This study was performed to identify the antineoplastic mechanism in gastric cancer cells affected by celecoxib, a selective COX-2 inhibitor.	Celecoxib	102-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-130
17661725-0	2007	A retrospective analysis of cardiovascular morbidity in metastatic hormone-refractory prostate cancer patients on high doses of the selective COX-2 inhibitor celecoxib.	Celecoxib	158-167	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	142-147
17609236-13	2007	However, approximately 4% of patients with a history of aspirin-induced skin reactions may experience a cutaneous reaction following a challenge to a COX-2 selective NSAID.	Aspirin	56-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	150-155
17609236-15	2007	CONCLUSIONS: Management of patients with aspirin/NSAID sensitivity includes avoidance of aspirin/nonselective NSAIDs, use of COX-2 selective NSAIDs, acetaminophen in doses less than 1000 mg, and desensitization.	Aspirin	41-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-130
17661725-3	2007	This study analyzes the cardiovascular and cerebral vascular morbidity associated with high doses of the COX-2 inhibitor, celecoxib, in patients with metastatic hormone-refractory prostate cancer (mHRPC).	Celecoxib	122-131	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-110
17710160-2	2007	Cross-talks between the WNT and cyclooxygenase-2 (COX-2 or PTGS2)/prostaglandin pathways have been suggested.	Prostaglandins	66-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-55
17661736-1	2007	Lumiracoxib is a highly selective COX-2 inhibitor with a novel chemical structure and a relatively short plasma half-life.	lumiracoxib	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-39
17566705-9	2007	These data indicate that survivin is a downstream target and effector of oncogenic Stat3 signalling in SCC, which is targeted by sulindac in a COX-2-independent manner.	Sulindac	129-137	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	143-148
17525166-0	2007	Utility and sensitivity of the sore throat pain model: results of a randomized controlled trial on the COX-2 selective inhibitor valdecoxib.	valdecoxib	129-139	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-108
17403097-9	2007	VSMC ability to synthesize PGE(2) and PGI(2) fitted mPGES-1 and COX-2 expression, respectively.	vsmc	0-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-69
17403097-9	2007	VSMC ability to synthesize PGE(2) and PGI(2) fitted mPGES-1 and COX-2 expression, respectively.	Prostaglandins E	27-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-69
17403097-9	2007	VSMC ability to synthesize PGE(2) and PGI(2) fitted mPGES-1 and COX-2 expression, respectively.	Prostaglandins I	38-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-69
17403097-11	2007	Results from COX-1 and COX-2 silencing and selective inhibition showed that both COX-1 and COX-2 were involved in the biosynthesis of PGE(2) and their relative contribution depended on the time of incubation with IL-1beta.	Prostaglandins E	134-137	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-28
17403097-11	2007	Results from COX-1 and COX-2 silencing and selective inhibition showed that both COX-1 and COX-2 were involved in the biosynthesis of PGE(2) and their relative contribution depended on the time of incubation with IL-1beta.	Prostaglandins E	134-137	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-96
17191216-3	2007	Since the discovery of a second isoform of COXs, it has been shown that PGF2alpha can be formed in vivo from arachidonic acid through both isoforms of COXs, namely cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2).	Dinoprost	72-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	211-216
17191216-3	2007	Since the discovery of a second isoform of COXs, it has been shown that PGF2alpha can be formed in vivo from arachidonic acid through both isoforms of COXs, namely cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2).	Arachidonic Acid	109-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	211-216
18297851-2	2007	At the end of 2000 the new age of AINEs was introduced, specially the selective inhibitors of the COX-2, whose main function is to block the production of the prostaglandins and the acute tissue inflammation.	Prostaglandins	159-173	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-103
17710160-10	2007	COX-2 overexpression correlated with cytoplasmic beta-catenin expression (even after tumors were stratified by CIMP status), but did not correlate significantly with nuclear or membrane expression.	Cyclic IMP	111-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
17650586-0	2007	Comparative QSAR modeling of COX-2 inhibitor 1,2-diarylimidazoles using E-state and physicochemical parameters.	1,2-diarylimidazoles	45-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34
17650586-1	2007	Considering importance of developing selective COX-2 inhibitors, COX-2 binding affinity data of 4-(2-aryl-1-imidazolyl)-phenyl methyl sulfones and sulfonamides (n = 83) have been modeled using electrotopological state (E-state) index as electronic parameter, hydrophobic substituent constant (pi) and molar refractivity (MR) of aryl ring substituents as lipophilic and steric parameters, respectively.	4-(2-aryl-1-imidazolyl)-phenyl methyl sulfones	96-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
17650586-1	2007	Considering importance of developing selective COX-2 inhibitors, COX-2 binding affinity data of 4-(2-aryl-1-imidazolyl)-phenyl methyl sulfones and sulfonamides (n = 83) have been modeled using electrotopological state (E-state) index as electronic parameter, hydrophobic substituent constant (pi) and molar refractivity (MR) of aryl ring substituents as lipophilic and steric parameters, respectively.	4-(2-aryl-1-imidazolyl)-phenyl methyl sulfones	96-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-70
17650586-6	2007	Also, an amino substituent is preferred over a methyl group at R2 position suggesting preference of the sulfonamide moiety over the methyl sulfone moiety for the COX-2 binding affinity.	Sulfonamides	104-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	162-167
17650586-6	2007	Also, an amino substituent is preferred over a methyl group at R2 position suggesting preference of the sulfonamide moiety over the methyl sulfone moiety for the COX-2 binding affinity.	dimethyl sulfone	132-146	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	162-167
17434872-1	2007	Lumiracoxib is the first example of a marketed COX-2 inhibitor of the arylacetic acid class, and it is reported to be the most selective COXIB in vivo.	lumiracoxib	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
17434872-1	2007	Lumiracoxib is the first example of a marketed COX-2 inhibitor of the arylacetic acid class, and it is reported to be the most selective COXIB in vivo.	arylacetic acid	70-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
17434872-3	2007	Using standard assays, lumiracoxib was found to be a poor inhibitor of purified ovine COX-1 and a relatively weak inhibitor of purified human COX-2.	lumiracoxib	23-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	142-147
17434872-5	2007	Kinetic studies with lumiracoxib demonstrated that it was a time-dependent and slowly reversible inhibitor of human COX-2 that exhibited at least two binding steps during inhibition.	lumiracoxib	21-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-121
17434872-7	2007	Inhibition studies demonstrated that the methyl group on the phenylacetic acid ring is required for COX-2 selectivity.	phenylacetic acid	61-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-105
17434872-8	2007	The chemical identity and position of the substituents on the lower aniline ring were important in determining the potency and extent of COX inhibition as well as COX-2 selectivity.	aniline	68-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	163-168
17434872-9	2007	Mutation of Ser-530 to Ala or Val-349 to Ala or Leu abolished the potent inhibition observed with wild-type human COX-2 and key lumiracoxib analogs.	lumiracoxib	128-139	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-119
17434872-10	2007	Interestingly, a Val-349 to Ile mutant was inhibited with equal potency to human COX-2 with 2,6-dichloro-, 2,6-dimethyl-, or 2-chloro-6-methyl-substituted inhibitors and, in the case of lumiracoxib, actually showed an increase in potency.	2,6-dichloro-	92-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-86
17434872-10	2007	Interestingly, a Val-349 to Ile mutant was inhibited with equal potency to human COX-2 with 2,6-dichloro-, 2,6-dimethyl-, or 2-chloro-6-methyl-substituted inhibitors and, in the case of lumiracoxib, actually showed an increase in potency.	2,6-dimethyl	107-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-86
17434872-11	2007	Taken together with a recent crystal structure of a lumiracoxib-COX-2 complex, the kinetic analyses presented herein of the inhibition of mutant COX-2s by lumiracoxib allows the definition of the molecular basis of COX-2 inhibition.	lumiracoxib	52-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-69
17434872-11	2007	Taken together with a recent crystal structure of a lumiracoxib-COX-2 complex, the kinetic analyses presented herein of the inhibition of mutant COX-2s by lumiracoxib allows the definition of the molecular basis of COX-2 inhibition.	lumiracoxib	52-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-150
17434872-11	2007	Taken together with a recent crystal structure of a lumiracoxib-COX-2 complex, the kinetic analyses presented herein of the inhibition of mutant COX-2s by lumiracoxib allows the definition of the molecular basis of COX-2 inhibition.	lumiracoxib	52-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-150
17434872-11	2007	Taken together with a recent crystal structure of a lumiracoxib-COX-2 complex, the kinetic analyses presented herein of the inhibition of mutant COX-2s by lumiracoxib allows the definition of the molecular basis of COX-2 inhibition.	lumiracoxib	155-166	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-69
17434872-11	2007	Taken together with a recent crystal structure of a lumiracoxib-COX-2 complex, the kinetic analyses presented herein of the inhibition of mutant COX-2s by lumiracoxib allows the definition of the molecular basis of COX-2 inhibition.	lumiracoxib	155-166	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-150
17434872-11	2007	Taken together with a recent crystal structure of a lumiracoxib-COX-2 complex, the kinetic analyses presented herein of the inhibition of mutant COX-2s by lumiracoxib allows the definition of the molecular basis of COX-2 inhibition.	lumiracoxib	155-166	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-150
17577102-7	2007	Rosuvastatin inhibited the expressions of ICAM-1, MCP-1, IL-8, IL-6, and COX-2 mRNA and protein levels.	Rosuvastatin Calcium	0-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-78
17622692-1	2007	BACKGROUND: Airway function is actively regulated by epithelium through generating PGE(2), the production of which depends on cyclooxygeneses (COX-1 and COX-2).	Dinoprostone	83-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	153-158
17361113-4	2007	Renal cortical COX2-derived prostanoids, particularly (PGI2) and PGE2 play critical roles in maintaining blood pressure and renal function in volume contracted states.	Prostaglandins	28-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-19
17361113-4	2007	Renal cortical COX2-derived prostanoids, particularly (PGI2) and PGE2 play critical roles in maintaining blood pressure and renal function in volume contracted states.	Epoprostenol	55-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-19
17361113-4	2007	Renal cortical COX2-derived prostanoids, particularly (PGI2) and PGE2 play critical roles in maintaining blood pressure and renal function in volume contracted states.	Dinoprostone	65-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-19
17361113-5	2007	Renal medullary COX2-derived prostanoids appear to have antihypertensive effect in individuals challenged with a high salt diet.	Prostaglandins	29-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-20
17361113-5	2007	Renal medullary COX2-derived prostanoids appear to have antihypertensive effect in individuals challenged with a high salt diet.	Salts	118-122	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-20
17392515-6	2007	RNA pull-down assay and RNA electrophoretic mobility shift assay demonstrated that the HuR shuttling by ATP is accompanied by an increased HuR binding to cyclooxygenase (COX)-2 mRNA.	Adenosine Triphosphate	104-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	154-176
17392515-7	2007	Physiologically, the ATP-dependent increase in RNA binding is linked with an augmentation in COX-2 mRNA stability and subsequent increase in prostaglandin E(2) synthesis.	Adenosine Triphosphate	21-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-98
17392515-7	2007	Physiologically, the ATP-dependent increase in RNA binding is linked with an augmentation in COX-2 mRNA stability and subsequent increase in prostaglandin E(2) synthesis.	Dinoprostone	141-159	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-98
17584158-1	2007	For more than a century, inhibition of prostaglandin biosynthesis via inhibition of the fatty acid cyclooxygenase (COX) has been achieved by non-steroidal anti-inflammatory drugs (NSAIDs), which targets both COX-1 and COX-2 and as such could be responsible for causing gastrointestinal (GI) toxicity.	Prostaglandins	39-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	218-223
17584158-8	2007	Several cytokines, reactive oxygen species (ROS) and mediators of inflammatory pathway such as activation of nuclear factor-kappaB (NF-kappaB) and COX-2 leads to an increase in cell proliferation, survival, and inhibition of pro-apoptotic pathway, ultimately resulting in tumor angiogenesis, invasion and metastasis.	Reactive Oxygen Species	19-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-152
17584158-8	2007	Several cytokines, reactive oxygen species (ROS) and mediators of inflammatory pathway such as activation of nuclear factor-kappaB (NF-kappaB) and COX-2 leads to an increase in cell proliferation, survival, and inhibition of pro-apoptotic pathway, ultimately resulting in tumor angiogenesis, invasion and metastasis.	Reactive Oxygen Species	44-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-152
17175104-0	2007	Acetaminophen selectively suppresses peripheral prostaglandin E2 release and increases COX-2 gene expression in a clinical model of acute inflammation.	Acetaminophen	0-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-92
17175104-1	2007	Acetaminophen is widely used for pain management as an alternative to NSAIDs and selective COX-2 inhibitors, but its action at a molecular level is still unclear.	Acetaminophen	0-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-96
17175104-6	2007	PGE2 release was suppressed by ketorolac, rofecoxib and acetaminophen compared to placebo at 3 h coincident with increased COX-2 gene expression in biopsies collected from the surgical site.	Dinoprostone	0-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-128
17175104-8	2007	COX-2 gene expression remained elevated at 24 h with continued ketorolac and acetaminophen treatment.	Ketorolac	63-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
17175104-8	2007	COX-2 gene expression remained elevated at 24 h with continued ketorolac and acetaminophen treatment.	Acetaminophen	77-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
17175104-10	2007	Acetaminophen suppression of PGE2 without inhibiting TXB2 release, when COX-2 gene expression is up-regulated, suggests that acetaminophen is a selective COX-2 inhibitor in vivo.	Acetaminophen	0-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	154-159
17175104-10	2007	Acetaminophen suppression of PGE2 without inhibiting TXB2 release, when COX-2 gene expression is up-regulated, suggests that acetaminophen is a selective COX-2 inhibitor in vivo.	Acetaminophen	125-138	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
17175104-10	2007	Acetaminophen suppression of PGE2 without inhibiting TXB2 release, when COX-2 gene expression is up-regulated, suggests that acetaminophen is a selective COX-2 inhibitor in vivo.	Acetaminophen	125-138	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	154-159
17175104-11	2007	The up-regulation of COX-2 gene and down-regulation of COX-1 gene expression suggests that acetaminophen may result in changes in COX-derived prostanoids with repeated doses.	Acetaminophen	91-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-26
17175104-11	2007	The up-regulation of COX-2 gene and down-regulation of COX-1 gene expression suggests that acetaminophen may result in changes in COX-derived prostanoids with repeated doses.	Prostaglandins	142-153	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-26
19075973-5	2007	On the other hand, prostaglandins influenced by COX-2 mediate the inflammatory process.	Prostaglandins	19-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-53
19075973-6	2007	The common anti-inflammatory drugs (like aspirin, ibuprofen, and naproxen) all act by blocking the action of both the COX-1 and COX-2 enzymes.	Aspirin	41-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	128-133
19075973-6	2007	The common anti-inflammatory drugs (like aspirin, ibuprofen, and naproxen) all act by blocking the action of both the COX-1 and COX-2 enzymes.	Ibuprofen	50-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	128-133
19075973-6	2007	The common anti-inflammatory drugs (like aspirin, ibuprofen, and naproxen) all act by blocking the action of both the COX-1 and COX-2 enzymes.	Naproxen	65-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	128-133
19075973-10	2007	Moreover, we will discuss recent patents of structural analogs of the COX-2 inhibitors celecoxib and valdecoxib, and novel potential pyridazine, triazole, indole, thione derivatives as a future target for the treatment of inflammation, pain and other diseases.	Celecoxib	87-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-75
19075973-10	2007	Moreover, we will discuss recent patents of structural analogs of the COX-2 inhibitors celecoxib and valdecoxib, and novel potential pyridazine, triazole, indole, thione derivatives as a future target for the treatment of inflammation, pain and other diseases.	valdecoxib	101-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-75
17459958-3	2007	These effects are largely mediated by inhibition of cyclooxygenase-1 and -2 (COX-1 and COX-2)-enzymes found throughout the body producing prostaglandins, which are important mediators of pain and fever, but also adaptive and protective reactions in many organs.	Prostaglandins	138-152	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-92
16959535-2	2007	The method is based on the complex formation of Co(II) and Pd(II) with 4-(2-pyridylazo) resorcinol (PAR) in acidic media and in the presence of sodium dodecyl sulfate (SDS) as a micellizing agent.	4-(2-pyridylazo)resorcinol	71-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-54
16959535-2	2007	The method is based on the complex formation of Co(II) and Pd(II) with 4-(2-pyridylazo) resorcinol (PAR) in acidic media and in the presence of sodium dodecyl sulfate (SDS) as a micellizing agent.	4-(2-pyridylazo)resorcinol	100-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-54
16959535-2	2007	The method is based on the complex formation of Co(II) and Pd(II) with 4-(2-pyridylazo) resorcinol (PAR) in acidic media and in the presence of sodium dodecyl sulfate (SDS) as a micellizing agent.	Sodium Dodecyl Sulfate	144-166	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-54
16959535-2	2007	The method is based on the complex formation of Co(II) and Pd(II) with 4-(2-pyridylazo) resorcinol (PAR) in acidic media and in the presence of sodium dodecyl sulfate (SDS) as a micellizing agent.	Sodium Dodecyl Sulfate	168-171	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-54
17593823-23	2007	CONCLUSION: Both COX-2 specific inhibitor Celecoxib and non-selective inhibitor Aspirin can potentially inhibit the tumor growth and induce apoptosis of SKOV3 cells, and the effect of Celecoxib is more potential than that of Aspirin.	Celecoxib	42-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22
17702421-5	2007	RESULTS: Positive expressions of COX-2, ERK, p38MAPK and NF-kappaB subunits were detected in CRS groups, which were stronger than those in control group, by immunohistochemistry and FQ-RT-PCR (P &lt; 0.05).	3-cresol	93-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-38
17702421-8	2007	Significantly positive correlation between protein and RNA expression of COX-2,ERK,p38MAPK and NF-kappaB subunits in each CRS group was confirmed by Pearson correlation treatment (P &lt; 0.05).	3-cresol	122-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-78
17702421-9	2007	Significantly positive correlation of protein and RNA expression between COX-2 and ERK, p38MAPK in same CRS group was also founded (P &lt; 0.05).	3-cresol	104-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-78
17702421-10	2007	The expression of COX-2 and the nucleic expression of NF-kappaB subunits in same CRS group was proved to be positively correlated (P &lt; 0.05).	3-cresol	81-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-23
17702421-12	2007	It indicates the involvement of ERK, p38MAPK and NF-kappaB signal transduction pathway in regulation of COX-2 in CRS.	3-cresol	113-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
17485089-5	2007	In addition, our immunoblot data revealed that DHMC treatment led to down-regulation of Bcl-xl, Bax, p21, Cox-2, p53 and upregulation of c-Myc.	7,8-dihydroxy-4-methylcoumarin	47-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-111
17629358-5	2007	In this review, we present that early synthesized COX-2 facilitates the recurrence of hippocampal seizures in rapid kindling model, and late induced COX-2 stimulates hippocampal neuron loss after kainic acid treatment.	Kainic Acid	196-207	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	149-154
17629358-7	2007	The short-term and sub-acute medication of selective COX-2 inhibitors that suppresses an elevation of prostaglandin E(2) (PGE(2)) may be an effective treatment to prevent neuronal loss after onset of neuronal excitatory diseases.	Dinoprostone	102-120	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-58
17629358-7	2007	The short-term and sub-acute medication of selective COX-2 inhibitors that suppresses an elevation of prostaglandin E(2) (PGE(2)) may be an effective treatment to prevent neuronal loss after onset of neuronal excitatory diseases.	Dinoprostone	122-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-58
17629358-9	2007	We found that these cells produce PGE(2) by synthesizing COX-2 and microsomal prostaglandin E synthase-1 (mPGES-1) in response to excitotoxicity and neuroinflammation.	Prostaglandins E	34-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-62
17722999-7	2007	Treatment with LY294002 effectively inhibited radiation- and cRGD-induced Akt phosphorylation and up-regulation of COX2 and increased apoptosis of HUVECs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-119
17030149-4	2007	The electrical conductivity of some ligands and their Co(II), Ni(II) and Cu(II) complexes in the temperature range 293-150K favoured their semiconducting properties where the metal ion forms a bridge to facilitate the flow of the current.	cu(ii)	73-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-60
17030149-4	2007	The electrical conductivity of some ligands and their Co(II), Ni(II) and Cu(II) complexes in the temperature range 293-150K favoured their semiconducting properties where the metal ion forms a bridge to facilitate the flow of the current.	Metals	175-180	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-60
17603279-6	2007	We demonstrated that histamine down-regulated the expression of beta-catenin, COX-2 and survivin in HuH-6 cells and that this was associated with caspase-3 activation and PARP cleavage.	Histamine	21-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-83
18069634-2	2007	METHODS: Immunohistochemical SP method was used to detect the expressions of COX-2 and MMP-9 in 72 cases of invasive carcinoma of cervix (ICC) and 16 cases of normal cervical epithelium remote from tumor (NCE), and the relationship between the expressions of COX-2 and MMP-9 in ICC and some factors relating to clinical pathology of cervical carcinoma such as histopathological grading, lymph node metastasis, stroma involvement and FIGO staging were analyzed statistically.	TFF2 protein, human	29-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-82
17257745-0	2007	Celecoxib induces apoptosis in COX-2 deficient human gastric cancer cells through Akt/GSK3beta/NAG-1 pathway.	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-36
17257745-1	2007	In this study, we analyzed the mechanisms of the apoptotic effects of celecoxib on COX-2 deficient gastric cancer cell line, MGC-803.	Celecoxib	70-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
17257745-6	2007	Our study demonstrated that Akt/GSK3beta/NAG-1 signal pathway may represent as the major mechanism of the COX-2-independent effects of celecoxib on gastric cancer cells.	Celecoxib	135-144	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-111
17594159-5	2007	Expression of COX-2 and p53 proteins was examined by immunohistochemistry in paraffin-embedded cancer tissue blocks, and the relationship between COX-2 and/or p53 expression with clinicopathologic parameters was analyzed.	Paraffin	77-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
17467667-4	2007	Palmitic acid (PA), the predominant saturated FFA released from adipose tissue, but not unsaturated FFA, induced an approximately 6-fold (p&lt;0.05) increase in IP-10 gene expression (and 2- to 4-fold increases in IL-8, MCP-1, COX-2, and MIG).	Palmitic Acid	0-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	227-232
17467667-4	2007	Palmitic acid (PA), the predominant saturated FFA released from adipose tissue, but not unsaturated FFA, induced an approximately 6-fold (p&lt;0.05) increase in IP-10 gene expression (and 2- to 4-fold increases in IL-8, MCP-1, COX-2, and MIG).	Palmitic Acid	15-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	227-232
17539631-10	2007	On the other hand, p-xylylenediphosphonic acid on reaction with Co(II) formed a 3D compound [Co(2)(O(3)PCH(2)C(6)H(4)CH(2)PO(3))(2)(H(2)O)(2)] (4) with a layered and pillared structure.	p-xylylenediphosphonic acid	19-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-70
17539631-10	2007	On the other hand, p-xylylenediphosphonic acid on reaction with Co(II) formed a 3D compound [Co(2)(O(3)PCH(2)C(6)H(4)CH(2)PO(3))(2)(H(2)O)(2)] (4) with a layered and pillared structure.	co(2)(o(3)	93-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-70
17290398-10	2007	Immunohistochemistry and Western blot analysis showed decreased nuclear localization of NF-kappaB and phosphorylated NF-kappaB protein and subsequently expression of MMP-9, Bcl-xL and Cox-2 in response to parthenolide treatment.	parthenolide	205-217	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	184-189
17368467-7	2007	The Langmuir monolayer capacity of the acid-activated montmorillonite is more than that of the parent montmorillonite (Cd(II): 32.7 and 33.2 mg/g; Co(II): 28.6 and 29.7 mg/g; Cu(II): 31.8 and 32.3 mg/g; Pb(II): 33.0 and 34.0 mg/g; and Ni(II): 28.4 and 29.5 mg/g for montmorillonite and acid-activated montmorillonite, respectively).	acid-activated montmorillonite	39-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-153
17368467-7	2007	The Langmuir monolayer capacity of the acid-activated montmorillonite is more than that of the parent montmorillonite (Cd(II): 32.7 and 33.2 mg/g; Co(II): 28.6 and 29.7 mg/g; Cu(II): 31.8 and 32.3 mg/g; Pb(II): 33.0 and 34.0 mg/g; and Ni(II): 28.4 and 29.5 mg/g for montmorillonite and acid-activated montmorillonite, respectively).	Bentonite	54-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-153
17368467-8	2007	The thermodynamics of the rate processes showed the adsorption of Co(II), Pb(II), and Ni(II) to be exothermic, accompanied by decreases in entropy and Gibbs free energy, while the adsorption of Cd(II) and Cu(II) was endothermic, with an increase in entropy and an appreciable decrease in Gibbs free energy.	cd(ii)	194-200	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-72
17368467-8	2007	The thermodynamics of the rate processes showed the adsorption of Co(II), Pb(II), and Ni(II) to be exothermic, accompanied by decreases in entropy and Gibbs free energy, while the adsorption of Cd(II) and Cu(II) was endothermic, with an increase in entropy and an appreciable decrease in Gibbs free energy.	cu(ii)	205-211	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-72
17534520-1	2007	Two isomorphous 3D CoII and NiII coordination polymers with the rare non-interpenetrated (10,3)-d topological network, showing spin-canted antiferromagnetism only in the CoII system.	Polymers	46-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	170-174
17514334-6	2007	In the case of the compound with the naphthalene derivative (9), the analytical and spectroscopic data suggest the occurrence of a low spin Co(II) complex.	naphthalene	37-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-146
17291447-2	2007	Cyclic voltammograms of [(C(5)Me(5))Co(bidentate)(CH(3)CN)](BF(4))(2) in CH(3)CN s showed two redox couples assignable to Co(II)/Co(III) and Co(I)/Co(II).	(c(5)me(5))co(bidentate)	25-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-128
17291447-2	2007	Cyclic voltammograms of [(C(5)Me(5))Co(bidentate)(CH(3)CN)](BF(4))(2) in CH(3)CN s showed two redox couples assignable to Co(II)/Co(III) and Co(I)/Co(II).	(c(5)me(5))co(bidentate)	25-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-153
17291447-2	2007	Cyclic voltammograms of [(C(5)Me(5))Co(bidentate)(CH(3)CN)](BF(4))(2) in CH(3)CN s showed two redox couples assignable to Co(II)/Co(III) and Co(I)/Co(II).	fluoroboric acid	60-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-128
17291447-2	2007	Cyclic voltammograms of [(C(5)Me(5))Co(bidentate)(CH(3)CN)](BF(4))(2) in CH(3)CN s showed two redox couples assignable to Co(II)/Co(III) and Co(I)/Co(II).	fluoroboric acid	60-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-153
17151091-1	2007	Aberrant arachidonic acid metabolism by cyclooxygenase (COX)-2 and 12-lipoxygenase (LOX) has implicated in carcinogenesis.	Arachidonic Acid	9-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-62
17545608-3	2007	Nonsteroidal anti-inflammatory drugs inhibit cyclooxygenase (COX)-1 and COX-2, which catalyze prostaglandin biosynthesis.	Prostaglandins	94-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
17594377-13	2007	According to the results of the only RCT, a 6-week course of the non-selective cyclooxygenase (COX) inhibitor naproxen may lead to slightly better OHQoL in patients with temporomandibular joint (TMJ) arthralgia than the selective COX-2 inhibitor celecoxib.	Naproxen	110-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	230-235
17461574-1	2007	Two new polynuclear azido-bridged Co(II) compounds with formulas catena-[Co(mu1,3-N3)(N3)(py)2(H2O)]n (1) and [Co(mu1,3-N3)2(4-acpy)2]n (2) (py=pyridine, 4-acpy=4-acetylpyridine) have been structurally and magnetically characterized.	3',5-diazido-2',3'-dideoxyuridine	20-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-40
17461574-1	2007	Two new polynuclear azido-bridged Co(II) compounds with formulas catena-[Co(mu1,3-N3)(N3)(py)2(H2O)]n (1) and [Co(mu1,3-N3)2(4-acpy)2]n (2) (py=pyridine, 4-acpy=4-acetylpyridine) have been structurally and magnetically characterized.	co(mu1,3-n3)(n3)(py)2(h2o)	73-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-40
17461574-1	2007	Two new polynuclear azido-bridged Co(II) compounds with formulas catena-[Co(mu1,3-N3)(N3)(py)2(H2O)]n (1) and [Co(mu1,3-N3)2(4-acpy)2]n (2) (py=pyridine, 4-acpy=4-acetylpyridine) have been structurally and magnetically characterized.	co(mu1,3-n3)2(4-acpy)2]n	111-135	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-40
17461574-1	2007	Two new polynuclear azido-bridged Co(II) compounds with formulas catena-[Co(mu1,3-N3)(N3)(py)2(H2O)]n (1) and [Co(mu1,3-N3)2(4-acpy)2]n (2) (py=pyridine, 4-acpy=4-acetylpyridine) have been structurally and magnetically characterized.	pyridine	144-152	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-40
17461574-1	2007	Two new polynuclear azido-bridged Co(II) compounds with formulas catena-[Co(mu1,3-N3)(N3)(py)2(H2O)]n (1) and [Co(mu1,3-N3)2(4-acpy)2]n (2) (py=pyridine, 4-acpy=4-acetylpyridine) have been structurally and magnetically characterized.	4-acpy	125-131	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-40
17461574-1	2007	Two new polynuclear azido-bridged Co(II) compounds with formulas catena-[Co(mu1,3-N3)(N3)(py)2(H2O)]n (1) and [Co(mu1,3-N3)2(4-acpy)2]n (2) (py=pyridine, 4-acpy=4-acetylpyridine) have been structurally and magnetically characterized.	4-acetylpyridine	161-177	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-40
17432846-1	2007	A series of nine mixed-ligand metal-organic frameworks (MOFs) have been prepared by the combination of a bent dipyridyl linker 4-amino-3,5-bis(4-pyridyl)-1,2,4-triazole (bpt) and three benzenedicarboxylate isomers (pa = phthalate, ip = isophthalate, and tp = terephthalate), respectively, with different metal ions such as CoII, NiII, CuII, ZnII, and CdII.	Protactinium	75-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	323-327
17499604-3	2007	We aimed to test the hypothesis that in patients with previous ulcer bleeding induced by non-selective NSAIDs, combined treatment with the COX 2 inhibitor celecoxib and the PPI esomeprazole would be better than celecoxib alone for prevention of recurrent ulcer bleeding.	Celecoxib	155-164	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-144
17030425-1	2007	A 2(3) factorial design was employed to evaluate the quantitative removal of Cu(II) and Co(II) on glutaraldehyde-cross-linked chitosan from kinetic isotherms, using chitosan masses of 100 and 300mg and temperatures of 25 and 35 degrees C. The adsorption parameters were analyzed statistically using modeling polynomial equations and a cumulative normal probability plot.	Glutaral	98-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-94
17030425-2	2007	The results indicated the higher quantitative preference of the chitosan for Cu(II) in relation to Co(II).	cu(ii)	77-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-105
17485013-0	2007	Aspirin and COX-2 inhibitor nimesulide potentiate adrenergic contractions of human gastroepiploic artery.	nimesulide	28-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-17
17485013-1	2007	BACKGROUND: The aim of the present study was to evaluate the intervention of COX-1- and COX-2-derived prostaglandins in the responses of human gastroepiploic artery to sympathetic stimulation and norepinephrine.	Prostaglandins	102-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-93
17485013-9	2007	Aspirin at high concentrations and the COX-2 selective inhibitor nimesulide potentiated the contractile response of gastroepiploic artery to adrenergic stimulation by inhibiting COX-2-derived PGI(2).	Prostaglandins I	192-195	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-44
17485013-1	2007	BACKGROUND: The aim of the present study was to evaluate the intervention of COX-1- and COX-2-derived prostaglandins in the responses of human gastroepiploic artery to sympathetic stimulation and norepinephrine.	Norepinephrine	196-210	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-93
17485013-9	2007	Aspirin at high concentrations and the COX-2 selective inhibitor nimesulide potentiated the contractile response of gastroepiploic artery to adrenergic stimulation by inhibiting COX-2-derived PGI(2).	Prostaglandins I	192-195	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	178-183
17485013-5	2007	RESULTS: The COX-1 and COX-2 inhibitor aspirin at high concentrations (10(-6) to 10(-5) mol/L) and the COX-2 inhibitor nimesulide (10(-6) mol/L) potentiated the contractile responses of the arterial rings to sympathetic neurogenic stimulation and norepinephrine.	Aspirin	39-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-28
17485013-5	2007	RESULTS: The COX-1 and COX-2 inhibitor aspirin at high concentrations (10(-6) to 10(-5) mol/L) and the COX-2 inhibitor nimesulide (10(-6) mol/L) potentiated the contractile responses of the arterial rings to sympathetic neurogenic stimulation and norepinephrine.	nimesulide	119-129	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-108
17485013-9	2007	Aspirin at high concentrations and the COX-2 selective inhibitor nimesulide potentiated the contractile response of gastroepiploic artery to adrenergic stimulation by inhibiting COX-2-derived PGI(2).	Aspirin	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	178-183
17485013-9	2007	Aspirin at high concentrations and the COX-2 selective inhibitor nimesulide potentiated the contractile response of gastroepiploic artery to adrenergic stimulation by inhibiting COX-2-derived PGI(2).	nimesulide	65-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-44
17485013-9	2007	Aspirin at high concentrations and the COX-2 selective inhibitor nimesulide potentiated the contractile response of gastroepiploic artery to adrenergic stimulation by inhibiting COX-2-derived PGI(2).	nimesulide	65-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	178-183
17595767-0	2007	Butyrate inhibits oral cancer cell proliferation and regulates expression of secretory phospholipase A2-X and COX-2.	Butyrates	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-115
17457134-5	2007	METHODS: The authors used 12 healthy volunteers to compare the effects of the specific COX-2 inhibitor sodium parecoxib (1 mg/kg) or placebo, administered intravenously in a double-blind and crossover fashion, on the electrophysiologic recordings of the nociceptive flexion (RIII) reflex.	sodium parecoxib	103-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-92
17595767-7	2007	NaBu also regulated COX-2 and sPLA2-X expression, and augmented PGE2 synthesis in OCC.	sethoxydim	0-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-25
17878525-11	2007	By using the COX-2 inhibitors rofecoxib and nimesulide, we were able to delay tumor-mediated wasting in vivo.	rofecoxib	30-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
17878525-11	2007	By using the COX-2 inhibitors rofecoxib and nimesulide, we were able to delay tumor-mediated wasting in vivo.	nimesulide	44-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
17395016-6	2007	The 4 microg/ml dilution of JP-8 also increased the activity of PARP-1 as well as the expression of iNOS and COX-2, indicating that lower doses of JP-8 also affect the regulation of proinflammatory factors in pulmonary macrophages.	JP-8	28-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-114
17520870-1	2007	NSAIDs and selective COX-2 inhibitors reduce the formation of prostanoids, particularly PGE2, to diminish inflammation.	Prostaglandins	62-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-26
17520870-1	2007	NSAIDs and selective COX-2 inhibitors reduce the formation of prostanoids, particularly PGE2, to diminish inflammation.	Dinoprostone	88-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-26
17652824-8	2007	As a result of research focused on reduction of the adverse effects of NSAIDs, selective COX-2 inhibitors, such as celecoxib and rofecoxib have been developed.	Celecoxib	115-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-94
17230539-9	2007	The COX-1/COX-2 data highlight the ambiguous functional role of prostanoid pathways in inflammatory bowel diseases.	Prostaglandins	64-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
17437847-8	2007	Furthermore, the addition of celecoxib sensitized LNCaP-Neo and LNCaP-COX-2 cells to the cytocidal effects of radiation.	Celecoxib	29-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-75
17337058-6	2007	Furthermore, elevated levels of prostacyclin secretion stimulated by TNF-alpha were markedly down-regulated by indomethacin and a selective COX-2 inhibitor.	Epoprostenol	32-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-145
17337058-6	2007	Furthermore, elevated levels of prostacyclin secretion stimulated by TNF-alpha were markedly down-regulated by indomethacin and a selective COX-2 inhibitor.	Indomethacin	111-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-145
17337058-7	2007	These results suggest that the production of prostacyclin in FDC is controlled by the regulation of upstream COX-2 but not by terminal PGIS protein production.	Epoprostenol	45-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-114
17612370-7	2007	Prostaglandins and nitric oxide biosynthesis is involved in inflammation, and isoforms of inducible nitric oxide synthase (iNOS) and of cyclooxygenase (COX-2) are responsible for the production of a great amount of these mediators.	Prostaglandins	0-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-157
17612370-7	2007	Prostaglandins and nitric oxide biosynthesis is involved in inflammation, and isoforms of inducible nitric oxide synthase (iNOS) and of cyclooxygenase (COX-2) are responsible for the production of a great amount of these mediators.	Nitric Oxide	19-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-157
17652824-8	2007	As a result of research focused on reduction of the adverse effects of NSAIDs, selective COX-2 inhibitors, such as celecoxib and rofecoxib have been developed.	rofecoxib	129-138	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-94
17404646-2	2007	Glycoligands using various monosaccharide platforms functionalised by three 2-picolyl groups and coordinated to Co(II) through the bidentate 2-picolyl ether moieties are interesting ligands as they efficiently induce chirality at the cobalt with a fine control of the structure through the central sugar scaffold.	glycoligands	0-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-118
17518513-1	2007	BACKGROUND: Suppression of prostacyclin (PGI2) is implicated in the cardiovascular hazard from inhibitors of cyclooxygenase (COX)-2.	Epoprostenol	27-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-131
17388586-1	2007	A new carboxylato-bridged CoII network of formula {Co((kappa1-kappa1)-(kappa1-mu2)-mu4-TDC)(mu2-H2O)0.5(H2O)}n (H2TDC=2,5-thiophenedicarboxylic acid) has been hydrothermally synthesized and characterized by single-crystal X-ray diffraction, thermogravimetric analysis, and IR and UV-visible spectroscopies.	Water	96-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-30
17388586-1	2007	A new carboxylato-bridged CoII network of formula {Co((kappa1-kappa1)-(kappa1-mu2)-mu4-TDC)(mu2-H2O)0.5(H2O)}n (H2TDC=2,5-thiophenedicarboxylic acid) has been hydrothermally synthesized and characterized by single-crystal X-ray diffraction, thermogravimetric analysis, and IR and UV-visible spectroscopies.	Water	104-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-30
17388586-1	2007	A new carboxylato-bridged CoII network of formula {Co((kappa1-kappa1)-(kappa1-mu2)-mu4-TDC)(mu2-H2O)0.5(H2O)}n (H2TDC=2,5-thiophenedicarboxylic acid) has been hydrothermally synthesized and characterized by single-crystal X-ray diffraction, thermogravimetric analysis, and IR and UV-visible spectroscopies.	h2tdc	112-117	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-30
17388586-1	2007	A new carboxylato-bridged CoII network of formula {Co((kappa1-kappa1)-(kappa1-mu2)-mu4-TDC)(mu2-H2O)0.5(H2O)}n (H2TDC=2,5-thiophenedicarboxylic acid) has been hydrothermally synthesized and characterized by single-crystal X-ray diffraction, thermogravimetric analysis, and IR and UV-visible spectroscopies.	2,5-Thiophenedicarboxylic acid	118-148	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-30
17388586-2	2007	The title compound is made of chains of CoII dimers interconnected by TDC2- ligands, showing an unprecedented asymmetric tetradentate coordination mode of the carboxylate functions.	carboxylate	159-170	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-44
19071674-0	2007	Comparative electrooxidation of sulphite by self-assembled monolayers (SAMs) of Co(II), Fe(II), Ni(II) and Mn(III) tetrakis benzylmercapto and dodecylmercapto metallophthalocyanines complexes on gold electrodes.	Sulfites	32-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-86
19071674-0	2007	Comparative electrooxidation of sulphite by self-assembled monolayers (SAMs) of Co(II), Fe(II), Ni(II) and Mn(III) tetrakis benzylmercapto and dodecylmercapto metallophthalocyanines complexes on gold electrodes.	SAMS Peptide	71-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-86
19071674-1	2007	This work reports on the use of Co(II), Fe(II), Mn(III) and Ni(II) tetrakis benzylmercapto and dodecylmercapto phthalocyanine complexes for gold electrode modification for electrooxidation of sulphite ions.	ni(ii) tetrakis benzylmercapto and dodecylmercapto phthalocyanine	60-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-38
19071674-1	2007	This work reports on the use of Co(II), Fe(II), Mn(III) and Ni(II) tetrakis benzylmercapto and dodecylmercapto phthalocyanine complexes for gold electrode modification for electrooxidation of sulphite ions.	Sulfites	192-200	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-38
17404646-2	2007	Glycoligands using various monosaccharide platforms functionalised by three 2-picolyl groups and coordinated to Co(II) through the bidentate 2-picolyl ether moieties are interesting ligands as they efficiently induce chirality at the cobalt with a fine control of the structure through the central sugar scaffold.	Monosaccharides	27-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-118
17404646-2	2007	Glycoligands using various monosaccharide platforms functionalised by three 2-picolyl groups and coordinated to Co(II) through the bidentate 2-picolyl ether moieties are interesting ligands as they efficiently induce chirality at the cobalt with a fine control of the structure through the central sugar scaffold.	2-picolyl ether	141-156	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-118
17404646-2	2007	Glycoligands using various monosaccharide platforms functionalised by three 2-picolyl groups and coordinated to Co(II) through the bidentate 2-picolyl ether moieties are interesting ligands as they efficiently induce chirality at the cobalt with a fine control of the structure through the central sugar scaffold.	Cobalt	234-240	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-118
17404646-2	2007	Glycoligands using various monosaccharide platforms functionalised by three 2-picolyl groups and coordinated to Co(II) through the bidentate 2-picolyl ether moieties are interesting ligands as they efficiently induce chirality at the cobalt with a fine control of the structure through the central sugar scaffold.	Sugars	298-303	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-118
17371009-2	2007	Thus, in this report, the generation and characterization of new mu-oxo, micro-hydroxo, and micro-peroxo (micro-X) assemblies of [(porphyrinate)MIII-X-CoII/III(TMPA)]n+ assemblies is described, where M = FeIII or CoIII and TMPA = tris(2-pyridylmethyl)amine.	trimethyl phosphate	160-164	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-155
17397653-0	2007	On-line selective detection of antioxidants free-radical scavenging activity based on Co(II)/EDTA-induced luminol chemiluminescence by flow injection analysis.	Free Radicals	44-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-92
17397653-0	2007	On-line selective detection of antioxidants free-radical scavenging activity based on Co(II)/EDTA-induced luminol chemiluminescence by flow injection analysis.	Luminol	106-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-92
17371009-2	2007	Thus, in this report, the generation and characterization of new mu-oxo, micro-hydroxo, and micro-peroxo (micro-X) assemblies of [(porphyrinate)MIII-X-CoII/III(TMPA)]n+ assemblies is described, where M = FeIII or CoIII and TMPA = tris(2-pyridylmethyl)amine.	tris(2-pyridylmethyl)amine	230-256	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-155
17397653-1	2007	This study establishes a new method to analyze the radical scavenging activity of antioxidants based on the luminol-H(2)O(2)-Co(II)/EDTA chemiluminescence and flow injection analysis.	Luminol	108-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-131
17397653-1	2007	This study establishes a new method to analyze the radical scavenging activity of antioxidants based on the luminol-H(2)O(2)-Co(II)/EDTA chemiluminescence and flow injection analysis.	Hydrogen Peroxide	116-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-131
17371009-3	2007	The mu-oxo complex [(F8TPP)FeIII-O-CoII(TMPA)]+ (1, F8TPP = tetrakis(2,6-difluorphenyl)porphyrinate) was isolated by an acid-base self-assembly reaction of a 1:1 mixture of (F8TPP)FeIII-OH and [CoII(TMPA)(MeCN)]2+ upon addition of triethylamine.	mu-oxo	4-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-39
17397653-2	2007	The method is based on the catalytic oxidation of hydrogen peroxide by Co(II)/EDTA complex, forming a free radical flux that can produce a stable chemiluminescence signal which is attenuated in the presence of antioxidants.	Hydrogen Peroxide	50-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-77
17397653-2	2007	The method is based on the catalytic oxidation of hydrogen peroxide by Co(II)/EDTA complex, forming a free radical flux that can produce a stable chemiluminescence signal which is attenuated in the presence of antioxidants.	Edetic Acid	78-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-77
17371009-3	2007	The mu-oxo complex [(F8TPP)FeIII-O-CoII(TMPA)]+ (1, F8TPP = tetrakis(2,6-difluorphenyl)porphyrinate) was isolated by an acid-base self-assembly reaction of a 1:1 mixture of (F8TPP)FeIII-OH and [CoII(TMPA)(MeCN)]2+ upon addition of triethylamine.	mu-oxo	4-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	194-198
17371009-3	2007	The mu-oxo complex [(F8TPP)FeIII-O-CoII(TMPA)]+ (1, F8TPP = tetrakis(2,6-difluorphenyl)porphyrinate) was isolated by an acid-base self-assembly reaction of a 1:1 mixture of (F8TPP)FeIII-OH and [CoII(TMPA)(MeCN)]2+ upon addition of triethylamine.	(f8tpp)	20-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-39
17371009-3	2007	The mu-oxo complex [(F8TPP)FeIII-O-CoII(TMPA)]+ (1, F8TPP = tetrakis(2,6-difluorphenyl)porphyrinate) was isolated by an acid-base self-assembly reaction of a 1:1 mixture of (F8TPP)FeIII-OH and [CoII(TMPA)(MeCN)]2+ upon addition of triethylamine.	(f8tpp)	20-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	194-198
17371009-3	2007	The mu-oxo complex [(F8TPP)FeIII-O-CoII(TMPA)]+ (1, F8TPP = tetrakis(2,6-difluorphenyl)porphyrinate) was isolated by an acid-base self-assembly reaction of a 1:1 mixture of (F8TPP)FeIII-OH and [CoII(TMPA)(MeCN)]2+ upon addition of triethylamine.	tetrakis(2,6-difluorphenyl)porphyrinate	60-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-39
17371009-3	2007	The mu-oxo complex [(F8TPP)FeIII-O-CoII(TMPA)]+ (1, F8TPP = tetrakis(2,6-difluorphenyl)porphyrinate) was isolated by an acid-base self-assembly reaction of a 1:1 mixture of (F8TPP)FeIII-OH and [CoII(TMPA)(MeCN)]2+ upon addition of triethylamine.	tetrakis(2,6-difluorphenyl)porphyrinate	60-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	194-198
17371009-6	2007	The micro-hydroxo analogue [(F8TPP)FeIII-(OH)-CoII(TMPA)]+ (2) [UV-vis lambdamax = 567 nm; delta 78 ppm (pyrrole-H); Evans NMR microeff = 3.7] was generated by addition of 1 equiv of triflic acid to 1.	Pyrroles	105-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-50
17440114-6	2007	The inductive effects of HPV16 E6 and E7 were mediated by enhanced binding of activator protein-1 to the cyclic AMP (cAMP)-responsive element (-59/-53) of the COX-2 promoter.	Cyclic AMP	105-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	159-164
17440114-6	2007	The inductive effects of HPV16 E6 and E7 were mediated by enhanced binding of activator protein-1 to the cyclic AMP (cAMP)-responsive element (-59/-53) of the COX-2 promoter.	Cyclic AMP	117-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	159-164
17440114-8	2007	Chromatin immunoprecipitation assays indicated that E6 and E7 oncoproteins induced the recruitment of phosphorylated c-Jun, c-Fos, UbcH5, and cAMP-responsive element binding protein-binding protein/p300 to the COX-2 promoter.	Cyclic AMP	142-146	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	210-215
17387398-0	2007	Cobalt(II)-(dpyo)-dicarboxylate networks: unique H-bonded assembly and rare bridging mode of dpyo in one of them [dpyo = 4,4"-dipyridyl N,N"-dioxide].	dpyo	12-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	7-9
17387398-0	2007	Cobalt(II)-(dpyo)-dicarboxylate networks: unique H-bonded assembly and rare bridging mode of dpyo in one of them [dpyo = 4,4"-dipyridyl N,N"-dioxide].	dpyo	93-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	7-9
17387398-0	2007	Cobalt(II)-(dpyo)-dicarboxylate networks: unique H-bonded assembly and rare bridging mode of dpyo in one of them [dpyo = 4,4"-dipyridyl N,N"-dioxide].	4,4"-dipyridyl n,n"-dioxide	121-148	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	7-9
17335184-1	2007	New nitrooxy-substituted 1,5-diarylimidazoles endowed with COX-2 inhibitory and vasodilator properties.	nitrooxy-substituted 1,5-diarylimidazoles	4-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-64
17388504-3	2007	When the decomposition is carried out under N2, the oxidation of Co(II) is suppressed, and the resulting oxide has the rock salt structure.	Sodium Chloride	119-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-71
17326631-4	2007	Compounds 3a and 3b do not show the incorporation of the metal into the cluster, but the CoII and NiII salts provide the Cl atom to generate the anionic cluster 3 stabilized by the [Co(DMF)6]2+ or [Ni(DMF)6]2+ ion.	co(dmf)	182-189	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-93
17326631-4	2007	Compounds 3a and 3b do not show the incorporation of the metal into the cluster, but the CoII and NiII salts provide the Cl atom to generate the anionic cluster 3 stabilized by the [Co(DMF)6]2+ or [Ni(DMF)6]2+ ion.	dmf)6	185-190	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-93
17326626-2	2007	The reaction in pyridine or DMF of this ligand with various M(AcO)2 salts (M = NiII, CoII, MnII) leads to very different products depending on the metal.	pyridine	16-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-89
17348645-6	2007	We investigate the stabilization of such an orbital configuration on the Co sites and find that it cannot be achieved in the ground state of isolated mononuclear fragments [CoII(NC)4(OH2)2]2- for any conformations of the coordinated water molecules and Co-N-C bond angles.	co-n	253-257	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	173-177
17326626-2	2007	The reaction in pyridine or DMF of this ligand with various M(AcO)2 salts (M = NiII, CoII, MnII) leads to very different products depending on the metal.	Dimethylformamide	28-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-89
17397743-1	2007	PURPOSE: To evaluate the safety and efficacy of the COX-2 inhibitor valdecoxib in treating macular edema after cataract surgery.	valdecoxib	68-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-57
17342386-2	2007	Physiologic concentrations of celecoxib (5-10 microM) inhibited 80% to 90% of PGE(2) production in HT-29 cells that express high levels of COX-2 protein.	Celecoxib	30-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-144
17342386-6	2007	The effect of celecoxib on cell growth inhibition was higher on the COX-2-positive HT-29 cell line (IC(50)=20 microM) than on the COX-2 deficient SW-480 cell line (IC(50)=35 microM).	Celecoxib	14-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-73
17342386-8	2007	These results support the need for additional evaluation of independent COX-2 pathways of celecoxib in chemoprevention of CRC.	Celecoxib	90-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
17397743-3	2007	METHODS: The COX-2 inhibitor valdecoxib (Bextra) was administered systemically to patients with significant visual loss resulting from macular edema in a prospective clinical trial.	valdecoxib	29-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
17397743-3	2007	METHODS: The COX-2 inhibitor valdecoxib (Bextra) was administered systemically to patients with significant visual loss resulting from macular edema in a prospective clinical trial.	valdecoxib	41-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
17270500-8	2007	The results demonstrate peripheral elevation of COX-2 after tissue injury, which may contribute to increased prostaglandin E(2) at the site of injury, pain onset, and the analgesic activity of both nonselective NSAIDs and selective COX-2 inhibitors.	Dinoprostone	109-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-53
17270500-8	2007	The results demonstrate peripheral elevation of COX-2 after tissue injury, which may contribute to increased prostaglandin E(2) at the site of injury, pain onset, and the analgesic activity of both nonselective NSAIDs and selective COX-2 inhibitors.	Dinoprostone	109-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	232-237
17241651-4	2007	Moreover, BjV up-regulated expression of COX-2 but not of the constitutive COX-1, suggesting that expressed COX-2 provides more substrate for synthesis of PGs by the respective terminal synthases, being the critical enzyme for PGs production in the late periods of BjV effect.	N-benzyl-1-{5-[(2-chloro-5-{5-(methylsulfonyl)-1-[3-(morpholin-4-yl)propyl]-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl}phenyl)ethynyl]-2-methoxyphenyl}methanamine	10-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-46
17241651-4	2007	Moreover, BjV up-regulated expression of COX-2 but not of the constitutive COX-1, suggesting that expressed COX-2 provides more substrate for synthesis of PGs by the respective terminal synthases, being the critical enzyme for PGs production in the late periods of BjV effect.	N-benzyl-1-{5-[(2-chloro-5-{5-(methylsulfonyl)-1-[3-(morpholin-4-yl)propyl]-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl}phenyl)ethynyl]-2-methoxyphenyl}methanamine	10-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-113
17241651-4	2007	Moreover, BjV up-regulated expression of COX-2 but not of the constitutive COX-1, suggesting that expressed COX-2 provides more substrate for synthesis of PGs by the respective terminal synthases, being the critical enzyme for PGs production in the late periods of BjV effect.	Prostaglandins	155-158	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-46
17241651-4	2007	Moreover, BjV up-regulated expression of COX-2 but not of the constitutive COX-1, suggesting that expressed COX-2 provides more substrate for synthesis of PGs by the respective terminal synthases, being the critical enzyme for PGs production in the late periods of BjV effect.	Prostaglandins	155-158	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-113
17241651-4	2007	Moreover, BjV up-regulated expression of COX-2 but not of the constitutive COX-1, suggesting that expressed COX-2 provides more substrate for synthesis of PGs by the respective terminal synthases, being the critical enzyme for PGs production in the late periods of BjV effect.	Prostaglandins	227-230	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-46
17241651-4	2007	Moreover, BjV up-regulated expression of COX-2 but not of the constitutive COX-1, suggesting that expressed COX-2 provides more substrate for synthesis of PGs by the respective terminal synthases, being the critical enzyme for PGs production in the late periods of BjV effect.	Prostaglandins	227-230	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-113
17241651-4	2007	Moreover, BjV up-regulated expression of COX-2 but not of the constitutive COX-1, suggesting that expressed COX-2 provides more substrate for synthesis of PGs by the respective terminal synthases, being the critical enzyme for PGs production in the late periods of BjV effect.	N-benzyl-1-{5-[(2-chloro-5-{5-(methylsulfonyl)-1-[3-(morpholin-4-yl)propyl]-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl}phenyl)ethynyl]-2-methoxyphenyl}methanamine	265-268	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-46
17241651-4	2007	Moreover, BjV up-regulated expression of COX-2 but not of the constitutive COX-1, suggesting that expressed COX-2 provides more substrate for synthesis of PGs by the respective terminal synthases, being the critical enzyme for PGs production in the late periods of BjV effect.	N-benzyl-1-{5-[(2-chloro-5-{5-(methylsulfonyl)-1-[3-(morpholin-4-yl)propyl]-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl}phenyl)ethynyl]-2-methoxyphenyl}methanamine	265-268	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-113
17241651-7	2007	Moreover, inhibition of COX-2 by selective drugs may be of value to counteract the severe local inflammation induced by BjV in the victims.	N-benzyl-1-{5-[(2-chloro-5-{5-(methylsulfonyl)-1-[3-(morpholin-4-yl)propyl]-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl}phenyl)ethynyl]-2-methoxyphenyl}methanamine	120-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
17386766-0	2007	A quantitative method for determination of Co(II) based on the inner filter effect of reagents on the Raman scattering signals of water.	Water	130-135	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-49
17386766-5	2007	If Co(II), which could form the binary complex of Co(II)/5-Cl-PADAB and consumes the 5-Cl-PADAB reagent, is present in such a case for a given amount of 5-Cl-PADAB solution, recovered Raman scattering signals could be observed and measured with a spectrofluorometer.	5-cl-padab	57-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	3-9
17386766-5	2007	If Co(II), which could form the binary complex of Co(II)/5-Cl-PADAB and consumes the 5-Cl-PADAB reagent, is present in such a case for a given amount of 5-Cl-PADAB solution, recovered Raman scattering signals could be observed and measured with a spectrofluorometer.	5-cl-padab	57-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-56
17386766-5	2007	If Co(II), which could form the binary complex of Co(II)/5-Cl-PADAB and consumes the 5-Cl-PADAB reagent, is present in such a case for a given amount of 5-Cl-PADAB solution, recovered Raman scattering signals could be observed and measured with a spectrofluorometer.	5-cl-padab	85-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	3-9
17386766-5	2007	If Co(II), which could form the binary complex of Co(II)/5-Cl-PADAB and consumes the 5-Cl-PADAB reagent, is present in such a case for a given amount of 5-Cl-PADAB solution, recovered Raman scattering signals could be observed and measured with a spectrofluorometer.	5-cl-padab	85-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-56
17386766-5	2007	If Co(II), which could form the binary complex of Co(II)/5-Cl-PADAB and consumes the 5-Cl-PADAB reagent, is present in such a case for a given amount of 5-Cl-PADAB solution, recovered Raman scattering signals could be observed and measured with a spectrofluorometer.	5-cl-padab	85-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	3-9
17386766-5	2007	If Co(II), which could form the binary complex of Co(II)/5-Cl-PADAB and consumes the 5-Cl-PADAB reagent, is present in such a case for a given amount of 5-Cl-PADAB solution, recovered Raman scattering signals could be observed and measured with a spectrofluorometer.	5-cl-padab	85-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-56
17325803-0	2007	Monomeric, two-coordinate Mn, Fe and Co(II) complexes featuring 2,6-(2,4,6-trimethylphenyl)phenyl ligands.	2,6-(2,4,6-trimethylphenyl)phenyl	64-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-43
17254563-9	2007	The inhibitors of cyclooxygenase (COX)-2 and protein kinase A (PKA) at 100 microM inhibited the actions of nicotine, suggesting that the endogenous prostaglandin E(2) might be, at least, partially involved the actions of nicotine.	Nicotine	107-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-40
17254563-9	2007	The inhibitors of cyclooxygenase (COX)-2 and protein kinase A (PKA) at 100 microM inhibited the actions of nicotine, suggesting that the endogenous prostaglandin E(2) might be, at least, partially involved the actions of nicotine.	Prostaglandins E	148-163	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-40
17254563-9	2007	The inhibitors of cyclooxygenase (COX)-2 and protein kinase A (PKA) at 100 microM inhibited the actions of nicotine, suggesting that the endogenous prostaglandin E(2) might be, at least, partially involved the actions of nicotine.	Nicotine	221-229	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-40
17410782-11	2007	The study further revealed that Co(II) is predominately present as a Co-hydroxide-like phase and/or Co-phyllosilicates, whereas Co(III) tends to be incorporated into a CoOOH-like phase and/or Co-phyllomanganates.	co-hydroxide	69-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-38
17410782-11	2007	The study further revealed that Co(II) is predominately present as a Co-hydroxide-like phase and/or Co-phyllosilicates, whereas Co(III) tends to be incorporated into a CoOOH-like phase and/or Co-phyllomanganates.	co-phyllosilicates	100-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-38
17410782-12	2007	In contrast to samples prepared in air, XAS experiments with samples prepared in the absence of oxygen revealed solely the presence of Co(II).	Oxygen	96-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-141
17286396-3	2007	From a magnetic point of view, these similar configurations describe a quasilinear, trimeric magnetic model (PTMMC-M(II)-PTMMC), in which the metal [Ni(II) or Co(II)]-radical magnetic-exchange coupling constants have been determined for the first time.	Metals	142-147	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	159-165
16797120-3	2007	We hypothesized that EGCG may exert cell cytotoxicity through modulating AMPK (AMP-activated protein kinase) followed by the decrease in COX-2 expression.	epigallocatechin gallate	21-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-142
16797120-4	2007	EGCG treatment to colon cancer cells resulted in a strong activation of AMPK and an inhibition of COX-2 expression.	epigallocatechin gallate	0-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-103
16797120-5	2007	The decreased COX-2 expression as well as prostaglandin E(2) secretion by EGCG was completely abolished by inhibiting AMPK by an AMPK inhibitor, Compound C. Also, the activation of AMPK was accompanied with the reduction of VEGF (vascular endothelial growth factor) and glucose transporter, Glut-1 in EGCG-treated cancer cells.	epigallocatechin gallate	74-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
16797120-5	2007	The decreased COX-2 expression as well as prostaglandin E(2) secretion by EGCG was completely abolished by inhibiting AMPK by an AMPK inhibitor, Compound C. Also, the activation of AMPK was accompanied with the reduction of VEGF (vascular endothelial growth factor) and glucose transporter, Glut-1 in EGCG-treated cancer cells.	epigallocatechin gallate	301-305	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
16797120-6	2007	These findings support the regulatory role of AMPK in COX-2 expression in EGCG-treated cancer cells.	epigallocatechin gallate	74-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-59
16797120-8	2007	AMPK, a molecule of newly defined cancer target, was shown to control COX-2 in EGCG-treated colon cancer cells.	epigallocatechin gallate	79-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-75
17339623-8	2007	Colorectal adenoma incidence was also reduced with non-ASA NSAID use in cohort studies (relative risk, 0.64 [CI, 0.48 to 0.85]) and case-control studies (relative risk, 0.54 [CI, 0.4 to 0.74]) and by COX-2 inhibitors in randomized, controlled trials (relative risk, 0.72 [CI, 0.68 to 0.77]).	Aspirin	55-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	200-205
17342254-8	2007	These results suggest that LPS enhances the production of nicotine-induced PGE(2) by an increase in COX-2 expression in osteoblasts, that nicotine-LPS-induced PGE2 interacts with the osteoblast Ep4 receptor primarily in autocrine or paracrine mode, and that the nicotine-LPS-induced PGE(2) then decreases ALPase activity and increases M-CSF expression.	Nicotine	58-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-105
17342254-8	2007	These results suggest that LPS enhances the production of nicotine-induced PGE(2) by an increase in COX-2 expression in osteoblasts, that nicotine-LPS-induced PGE2 interacts with the osteoblast Ep4 receptor primarily in autocrine or paracrine mode, and that the nicotine-LPS-induced PGE(2) then decreases ALPase activity and increases M-CSF expression.	Prostaglandins E	75-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-105
17342254-8	2007	These results suggest that LPS enhances the production of nicotine-induced PGE(2) by an increase in COX-2 expression in osteoblasts, that nicotine-LPS-induced PGE2 interacts with the osteoblast Ep4 receptor primarily in autocrine or paracrine mode, and that the nicotine-LPS-induced PGE(2) then decreases ALPase activity and increases M-CSF expression.	Nicotine	138-146	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-105
17342254-8	2007	These results suggest that LPS enhances the production of nicotine-induced PGE(2) by an increase in COX-2 expression in osteoblasts, that nicotine-LPS-induced PGE2 interacts with the osteoblast Ep4 receptor primarily in autocrine or paracrine mode, and that the nicotine-LPS-induced PGE(2) then decreases ALPase activity and increases M-CSF expression.	Nicotine	138-146	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-105
17444277-5	2007	Such temporal adaptation occurs via modulators such as nitric oxide (NO), primarily derived from NOS-1, angiotensin II and COX-2 products.	Nitric Oxide	55-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-128
17295901-11	2007	CONCLUSION: Our results suggest that expression of mPGES in addition to COX-2 plays a role in increasing PGE(2) production in endometriosis.	Dinoprostone	105-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
17822232-0	2007	Determination of cobalt at ng ml(-1) level in water using the electrophilic substiution complexation between co(II) and chlorophosphonazo-p-CL-Cu(II) complex.	chlorophosphonazo-p-cl	120-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-115
17089125-3	2007	The results showed that both U937 and Mono Mac 6 cells demonstrated constitutive activation of COX-2 expression; treatment by 15d-PGJ2 and TGZ could induce apoptosis remarkably in human monocyte leukemia cells by disruption of mitochondrial membrane potential, activation of caspase-3, and causing cleavage of the caspase substrate poly (ADP-ribose) polymerase (PARP).	15-deoxyprostaglandin J2	126-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-100
17089125-3	2007	The results showed that both U937 and Mono Mac 6 cells demonstrated constitutive activation of COX-2 expression; treatment by 15d-PGJ2 and TGZ could induce apoptosis remarkably in human monocyte leukemia cells by disruption of mitochondrial membrane potential, activation of caspase-3, and causing cleavage of the caspase substrate poly (ADP-ribose) polymerase (PARP).	Troglitazone	139-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-100
17089125-4	2007	Further studies revealed that treatment by both 15d-PGJ2 and TGZ remarkably downregulated COX-2 expression in these two kind of monocyte leukemia cells as measured by reverse transcriptase PCR (RT-PCR) and Western blot.	15-deoxyprostaglandin J2	48-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-95
17089125-4	2007	Further studies revealed that treatment by both 15d-PGJ2 and TGZ remarkably downregulated COX-2 expression in these two kind of monocyte leukemia cells as measured by reverse transcriptase PCR (RT-PCR) and Western blot.	Troglitazone	61-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-95
17822232-0	2007	Determination of cobalt at ng ml(-1) level in water using the electrophilic substiution complexation between co(II) and chlorophosphonazo-p-CL-Cu(II) complex.	Cobalt	17-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-115
17822232-0	2007	Determination of cobalt at ng ml(-1) level in water using the electrophilic substiution complexation between co(II) and chlorophosphonazo-p-CL-Cu(II) complex.	Water	46-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-115
17184177-3	2007	Glomerular hyperfiltration, one of the characteristics of early diabetic nephropathy, may be caused by mitochondrial ROS through activation of COX-2 gene transcription, followed by PGE2 overproduction.	Reactive Oxygen Species	117-120	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	143-148
17293239-0	2007	Enhancement of glioblastoma radioresponse by a selective COX-2 inhibitor celecoxib: inhibition of tumor angiogenesis with extensive tumor necrosis.	Celecoxib	73-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-62
17293239-1	2007	PURPOSE: Toward improved glioblastoma multiforme treatment, we determined whether celecoxib, a selective cyclooxygenase (COX)-2 inhibitor, could enhance glioblastoma radiosensitivity by inducing tumor necrosis and inhibiting tumor angiogenesis.	Celecoxib	82-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-127
17316360-6	2007	This study investigated the effect of aspirin and a COX2 inhibitor (rofecoxib) on an HNPCC EC cell line model (Ishikawa) by assessing the effect on proliferation, apoptosis, the cell cycle, and MMR gene expression.	rofecoxib	68-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-56
17308870-6	2007	The distinct mechanisms of action allow CC-4047 and a COX2-selective NSAID to work additively to block PG secretion from monocytes.	Prostaglandins	103-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-58
17308870-8	2007	CC-4047 also inhibits COX2 and PG production in monocytes derived from patients with sickle cell disease (SCD).	pomalidomide	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-26
17322148-1	2007	The objectives of these analyses were to (1) develop a population pharmacokinetic/pharmacodynamic model for a novel COX-2 inhibitor (CS-706) using data from primarily Caucasian subjects, (2) predict responses in subpopulations of interest (including Japanese subjects), and (3) correlate pharmacodynamic parameters to safety outcomes.	apricoxib	133-139	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-121
17322148-4	2007	An E(max) model described relationships between CS-706 plasma concentrations and COX-1 and COX-2 inhibition.	Cesium	48-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-96
17322148-5	2007	CS-706 potency (EC(50)) was 397 ng/mL for COX-1 and 20 ng/mL for COX-2.	Cesium	0-2	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-70
17272385-15	2007	The prostanoid produced by COX-2 functionally antagonizes the effects of induction of NOS.	Prostaglandins	4-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-32
17302909-9	2007	NS-398, a COX-2 inhibitor, inhibited TGF-beta-induced VEGF production in a dose-dependent manner.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	0-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
17380299-0	2007	The effect of COX-2 inhibitor, nimesulide, on angiogenetic factors in primary endometrial carcinoma cell culture.	nimesulide	31-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
17380299-2	2007	Angiogenesis is enhanced by prostaglandins (PGs) that are synthesised by the catalysis of cyclooxygenases (COX-1 and COX-2) from arachidonic acid.	Prostaglandins	28-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-122
17380299-2	2007	Angiogenesis is enhanced by prostaglandins (PGs) that are synthesised by the catalysis of cyclooxygenases (COX-1 and COX-2) from arachidonic acid.	Prostaglandins	44-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-122
17380299-2	2007	Angiogenesis is enhanced by prostaglandins (PGs) that are synthesised by the catalysis of cyclooxygenases (COX-1 and COX-2) from arachidonic acid.	Arachidonic Acid	129-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-122
17380211-1	2007	Lumiracoxib is a selective cyclooxygenase (COX)-2 inhibitor that possesses a carboxylic acid group that makes it weakly acidic.	lumiracoxib	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-49
17380211-4	2007	This unique property suggests that lumiracoxib, while having reduced systemic exposure, can still reach sites where COX-2 inhibition is required for pain relief.	lumiracoxib	35-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-121
17380211-9	2007	Large clinical trials where lumiracoxib was administered to patients with osteoarthritis have demonstrated that this drug is equally effective as other COX-2 inhibitors and nonsteroidal anti-inflammatory drugs (NSAIDs).	lumiracoxib	28-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-157
17431384-2	2007	AIM: This study was designed to investigate the role of COX-2 inhibitor nimesulide in cell growth and apoptosis of the cultured human hepatocellular carcinoma HepG2 cells.	nimesulide	72-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-61
17431384-4	2007	RESULTS: Our results showed that the treatment of HepG2 cells with more than 50 microM of nimesulide suppressed COX-2 enzyme activity because of reduced PGE(2) production, and then induced growth inhibition and cell apoptosis despite no alterations of COX-2 protein expression.	nimesulide	90-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-117
17431384-4	2007	RESULTS: Our results showed that the treatment of HepG2 cells with more than 50 microM of nimesulide suppressed COX-2 enzyme activity because of reduced PGE(2) production, and then induced growth inhibition and cell apoptosis despite no alterations of COX-2 protein expression.	nimesulide	90-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	252-257
17822232-1	2007	The chromophore chlorophosphonazo-p-Cl (PCCPA) was used to complex Co(II) and Cu(II) at pH 9.18.	chlorophosphonazo-p-cl	16-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-73
17822232-1	2007	The chromophore chlorophosphonazo-p-Cl (PCCPA) was used to complex Co(II) and Cu(II) at pH 9.18.	pccpa	40-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-73
17822232-3	2007	Co(II) could competitively substitute Cu(II) from the Cu(II)-PCCPA complex via electrophilic effect.	cu(ii)	38-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
17822232-3	2007	Co(II) could competitively substitute Cu(II) from the Cu(II)-PCCPA complex via electrophilic effect.	cu(ii)-pccpa	54-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
17822232-5	2007	The proposed method has been applied to the direct detection of Co(II) in surface water and wastewater with good percent of recovery.	Water	82-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-70
16905570-8	2007	CONCLUSION: An antineuropathological role for COX2 in the preterm brain may help account for the lack of effect of indomethacin treatment in improving neurocognitive outcomes in children born preterm, despite reported reduction in apparent brain injury.	Indomethacin	115-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-50
17319904-0	2007	Reticulated platelets and uninhibited COX-1 and COX-2 decrease the antiplatelet effects of aspirin.	Aspirin	91-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-53
17319904-2	2007	Immature (reticulated) platelets may modulate the antiplatelet effects of aspirin through uninhibited cyclooxygenase (COX)-1 and COX-2.	Aspirin	74-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-134
17536451-2	2007	METHOD: The expression of COX-2 protein was examined in 30 radiosensitive and 30 radioresistant poorly differentiated NPC by immunohistochemical staining (SP method) before radiotherapy.	TFF2 protein, human	155-157	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-31
17276520-1	2007	The imbalance theory proposes that arterial thrombosis is dependent on a ratio or balance between the cyclooxygenase (COX)-1-dependent generation of thromboxane in platelets and the COX-2-dependent generation of prostacyclin in the endothelium.	Epoprostenol	212-224	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	182-187
17276520-2	2007	Accordingly, by reducing endothelium-derived prostacyclin levels, selective COX-2 inhibitors would increase susceptibility to vasoconstriction, platelet activation and atherothrombosis.	Epoprostenol	45-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-81
19071415-0	2007	Chemically modified silica gel with aminothioamidoanthraquinone for solid phase extraction and preconcentration of Pb(II), Cu(II), Ni(II), Co(II) and Cd(II).	Silica Gel	20-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-145
19071415-0	2007	Chemically modified silica gel with aminothioamidoanthraquinone for solid phase extraction and preconcentration of Pb(II), Cu(II), Ni(II), Co(II) and Cd(II).	aminothioamidoanthraquinone	36-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-145
19071415-2	2007	The metal sorption properties of modified silica were studied towards Pb(II), Cu(II), Ni(II), Co(II) and Cd(II).	Metals	4-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-100
19071415-2	2007	The metal sorption properties of modified silica were studied towards Pb(II), Cu(II), Ni(II), Co(II) and Cd(II).	Silicon Dioxide	42-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-100
17309209-0	2007	"Two-point" assembling of Zn(II) and Co(II) metalloporphyrins derivatized with a crown ether substituent in Langmuir and Langmuir-Blodgett films.	Ether	87-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-43
17274600-0	2007	Evidence that the principal CoII-binding site in human serum albumin is not at the N-terminus: implication on the albumin cobalt binding test for detecting myocardial ischemia.	Cobalt	122-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-32
17274600-2	2007	Four metal-binding sites with different specificities have been described in HSA: (i) the N-terminal site provided by Asp1, Ala2, and His3, (ii) the site at the reduced Cys34, (iii) site A, including His67 as a ligand, and (iv) the nonlocalized site B. HSA can bind CoII, and HSA was proposed to be involved in CoII transport.	Metals	5-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	266-270
17274600-2	2007	Four metal-binding sites with different specificities have been described in HSA: (i) the N-terminal site provided by Asp1, Ala2, and His3, (ii) the site at the reduced Cys34, (iii) site A, including His67 as a ligand, and (iv) the nonlocalized site B. HSA can bind CoII, and HSA was proposed to be involved in CoII transport.	Metals	5-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	311-315
17274600-3	2007	Recently, binding of CoII to HSA has attracted much interest due to the so-called albumin cobalt binding (ACB) test approved by the Food and Drug Administration for evaluation of myocardial ischemia.	Cobalt	90-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-25
17274600-3	2007	Recently, binding of CoII to HSA has attracted much interest due to the so-called albumin cobalt binding (ACB) test approved by the Food and Drug Administration for evaluation of myocardial ischemia.	acb	106-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-25
17309209-9	2007	In the Co(TPMCP) Langmuir films formed on the water subphases, Co(II) was complexed by aromatic but not cyclic heteroaliphatic ligands, while, in these films formed on the NaCl subphase solutions, the metalloporphyrin was also complexed by DABCO.	Water	46-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-69
17308114-5	2007	Moreover, COX-1/COX-2 inhibitors block ET-induced PGE(2) and VEGF secretion, matrix metalloproteinase (MMP) activation, and cell invasion, indicating that both enzymes function as downstream mediators of ET-induced invasive properties.	Prostaglandins E	50-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-21
17166726-0	2007	Synthesis and in vivo evaluation of [18F]-4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide as a PET imaging probe for COX-2 expression.	[18f]-4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1h-pyrazol-1-yl]benzenesulfonamide	36-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	146-151
17166726-1	2007	Synthesis of [18F]4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide ([18F]celecoxib), a selective COX-2 inhibitor, is achieved via a bromide to [18F]F- exchange reaction.	[18f]4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1h-pyrazol-1-yl]benzenesulfonamide	13-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-130
17166726-1	2007	Synthesis of [18F]4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide ([18F]celecoxib), a selective COX-2 inhibitor, is achieved via a bromide to [18F]F- exchange reaction.	Celecoxib	101-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-130
17131340-2	2007	Expression of COX-2 is detectable in 75% of PCs among which 50% showed overexpression, suggesting the importance of COX-2 enzyme and its metabolic product prostaglandin E2 (PGE(2)) in PC.	Dinoprostone	155-171	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
17436566-2	2007	The relationship between experimentally derived data on the antioxidant capacity, cytotoxicity and COX-2 inhibition for a range of 2-methoxyphenols and their calculated descriptors was investigated.	Guaiacol	131-147	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-104
17131340-2	2007	Expression of COX-2 is detectable in 75% of PCs among which 50% showed overexpression, suggesting the importance of COX-2 enzyme and its metabolic product prostaglandin E2 (PGE(2)) in PC.	Dinoprostone	155-171	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-121
17436566-3	2007	MATERIALS AND METHODS: Quantitative structure-activity relationship (QSAR) studies were performed on a series of 2-methoxyphenols that act as COX-2 inhibitors using electronic descriptors, such as the highest occupied molecular orbital (HOMO), the lowest unoccupied molecular orbital (LUMO), ionization potential (IP), chemical hardness (q), and electronegativity (chi), which were calculated by the CONFLEXIPM3 method.	Guaiacol	113-129	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	142-147
17131340-2	2007	Expression of COX-2 is detectable in 75% of PCs among which 50% showed overexpression, suggesting the importance of COX-2 enzyme and its metabolic product prostaglandin E2 (PGE(2)) in PC.	Prostaglandins E	173-176	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
17436566-8	2007	The majority of 2-methoxyphenols studied were COX-2 inhibitors.	Guaiacol	16-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
17131340-2	2007	Expression of COX-2 is detectable in 75% of PCs among which 50% showed overexpression, suggesting the importance of COX-2 enzyme and its metabolic product prostaglandin E2 (PGE(2)) in PC.	Prostaglandins E	173-176	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-121
17131340-3	2007	Here the authors report the synthesis and biological activity of a novel COX-2 inhibitor, FPA-306, and its effects on PC cells with different levels of COX-2 expression.	fpa	90-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-78
17292766-9	2007	INTERPRETATION: There were significantly fewer upper gastrointestinal clinical events with the COX-2 selective inhibitor etoricoxib than with the traditional NSAID diclofenac due to a decrease in uncomplicated events, but not in the more serious complicated events.	Etoricoxib	121-131	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-100
17225908-1	2007	Ferrocene carboxamide, FcCONH(2), forms homo- and heteroleptic complexes with Co(II), Ni(II) and Cu(II) via coordination of its carbonyl group.	ferrocene carboxamide	0-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-84
17386604-5	2007	The selectivity coefficients (S(Cu/Me)) for Me=Ni(II), Co(II) are 45.0 and 38.5, respectively.	Copper	32-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-61
17225908-2	2007	Whereas for both Co(II) and Ni(II), hexaferrocenyl complexes are obtained in the presence of BF(4)(-) anion, in the case of Cu(II) a tetraferrocenyl species is observed in the presence of triflate anion.	bf(4)(-) anion	93-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-23
17263391-1	2007	In the presence of the third generation Grubbs catalyst, the ring-expanding olefin metathesis of a monocyclooct-4-en-1-yl functionalized salen ligand and the corresponding Co(II)(salen) complex at low monomer concentrations results in the exclusive formation of macrocyclic oligomeric structures with the salen moieties being attached in an unsymmetrical, flexible, pendent manner.	grubbs	40-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	172-178
17263391-1	2007	In the presence of the third generation Grubbs catalyst, the ring-expanding olefin metathesis of a monocyclooct-4-en-1-yl functionalized salen ligand and the corresponding Co(II)(salen) complex at low monomer concentrations results in the exclusive formation of macrocyclic oligomeric structures with the salen moieties being attached in an unsymmetrical, flexible, pendent manner.	Alkenes	76-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	172-178
17263391-1	2007	In the presence of the third generation Grubbs catalyst, the ring-expanding olefin metathesis of a monocyclooct-4-en-1-yl functionalized salen ligand and the corresponding Co(II)(salen) complex at low monomer concentrations results in the exclusive formation of macrocyclic oligomeric structures with the salen moieties being attached in an unsymmetrical, flexible, pendent manner.	monocyclooct-4-en-1-yl	99-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	172-178
17263391-1	2007	In the presence of the third generation Grubbs catalyst, the ring-expanding olefin metathesis of a monocyclooct-4-en-1-yl functionalized salen ligand and the corresponding Co(II)(salen) complex at low monomer concentrations results in the exclusive formation of macrocyclic oligomeric structures with the salen moieties being attached in an unsymmetrical, flexible, pendent manner.	disalicylaldehyde ethylenediamine	137-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	172-178
17257035-0	2007	Cyanide-promoted demetalation of TrpyNiNCO: a route to sensitive metallotripyrrins of CoII, FeII, and MnII.	Cyanides	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-90
17257035-0	2007	Cyanide-promoted demetalation of TrpyNiNCO: a route to sensitive metallotripyrrins of CoII, FeII, and MnII.	metallotripyrrins	65-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-90
17257041-1	2007	This work presents the synthesis and characterization of metalated oligopeptide duplex assemblies composed of artificial oligopeptides bearing tethered phenyl terpyridine ligands that are coordinated to Co(II) and Fe(II) ions.	phenyl terpyridine	152-170	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	203-209
17453399-2	2007	METHODS: We performed a randomized controlled study to evaluate the effect of the selective COX-2 inhibitor rofecoxib compared to that of indomethacin on the incidence and extent of heterotopic ossification in patients who had undergone hip replacement surgery.	rofecoxib	108-117	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-97
17453399-9	2007	INTERPRETATION: After short-term administration, the selective COX-2 inhibitor rofecoxib was effective in preventing heterotopic ossification after total hip arthroplasty.	rofecoxib	79-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-68
17098211-11	2007	Moreover, pharmacological inhibition of PKCdelta or the expression of a dominant-negative form of PKCdelta in myotubes completely abolished COX-2 inhibitor-dependent stimulation of hexose uptake.	Hexoses	181-187	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-145
17098211-12	2007	This study shows that selective COX-2 inhibitors activate a unique PKCdelta-dependent pathway to increase GLUT-4 abundance in the plasma membrane of myotubes and augment the rate of hexose transport.	Hexoses	182-188	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-37
17179945-1	2007	BACKGROUND AND PURPOSE: The prostamides (prostaglandin-ethanolamides) and prostaglandin (PG) glyceryl esters are biosynthesized by COX-2 from the respective endocannabinoids anandamide and 2-arachidonyl glycerol.	Bimatoprost	28-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-136
17179945-1	2007	BACKGROUND AND PURPOSE: The prostamides (prostaglandin-ethanolamides) and prostaglandin (PG) glyceryl esters are biosynthesized by COX-2 from the respective endocannabinoids anandamide and 2-arachidonyl glycerol.	prostaglandin-ethanolamides	41-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-136
17179945-1	2007	BACKGROUND AND PURPOSE: The prostamides (prostaglandin-ethanolamides) and prostaglandin (PG) glyceryl esters are biosynthesized by COX-2 from the respective endocannabinoids anandamide and 2-arachidonyl glycerol.	prostaglandin (pg) glyceryl esters	74-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-136
17179945-1	2007	BACKGROUND AND PURPOSE: The prostamides (prostaglandin-ethanolamides) and prostaglandin (PG) glyceryl esters are biosynthesized by COX-2 from the respective endocannabinoids anandamide and 2-arachidonyl glycerol.	anandamide	174-184	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-136
17179945-1	2007	BACKGROUND AND PURPOSE: The prostamides (prostaglandin-ethanolamides) and prostaglandin (PG) glyceryl esters are biosynthesized by COX-2 from the respective endocannabinoids anandamide and 2-arachidonyl glycerol.	glyceryl 2-arachidonate	189-211	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-136
17251214-4	2007	Furthermore, we explored if combinations of either of these drugs with the COX-2 inhibitor parecoxib could improve its efficacy.	parecoxib	91-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
17140631-5	2007	Putative chelate ring formation is consistent with a relatively negative entropy change in step A, the stronger Co(II) binding step by HA functional groups, and could relate to "non-exchangeable" metal binding by HSs.	Metals	196-201	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-118
17226071-3	2007	Interestingly, low doses of nimesulide and celecoxib increase the levels of Prostaglandin E(2) and COX-2, and protect against subsequent 100% ethanol exposition, suggesting that these drugs may act as "mild irritants" to gastric mucosa.	nimesulide	28-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-104
17226071-3	2007	Interestingly, low doses of nimesulide and celecoxib increase the levels of Prostaglandin E(2) and COX-2, and protect against subsequent 100% ethanol exposition, suggesting that these drugs may act as "mild irritants" to gastric mucosa.	Celecoxib	43-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-104
16675095-2	2007	The aim of the study was to investigate if NO has an effect on cervical expression of cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2), the two main isoenzymes involved in prostaglandin synthesis, and to localize these enzymes within the cervix.	Prostaglandins	177-190	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	133-138
16675095-8	2007	CONCLUSIONS: Vaginal administration of IMN induces increased cervical expression of COX-2, but not of COX-1.	isosorbide-5-mononitrate	39-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-89
16645868-1	2007	After the oral administration of the COX 2 inhibitor rofecoxib (Vioxx) as part of an oral provocation test, a 64-year-old woman developed acute anterograde and retrograde amnesia which lasted for several hours.	rofecoxib	53-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-42
16645868-1	2007	After the oral administration of the COX 2 inhibitor rofecoxib (Vioxx) as part of an oral provocation test, a 64-year-old woman developed acute anterograde and retrograde amnesia which lasted for several hours.	rofecoxib	64-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-42
16996114-4	2007	METHODS: Western blot analysis was utilized to determine COX-2 protein expression levels in the 2008, cisplatin-sensitive, and C13*, cisplatin-resistant, cell lines.	Cisplatin	102-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-62
16996114-4	2007	METHODS: Western blot analysis was utilized to determine COX-2 protein expression levels in the 2008, cisplatin-sensitive, and C13*, cisplatin-resistant, cell lines.	Cisplatin	133-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-62
17178390-5	2007	EPA also attenuated the production of cyclooxygenase (COX)-2, inducible nitric oxide synthase (iNOS) and proinflammatory cytokines at mRNA and/or protein levels.	Eicosapentaenoic Acid	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-60
17323186-3	2007	Several animal and clinical studies have reported the chemopreventive effect of celecoxib, a selective COX-2 inhibitor; and in particular, a few studies have shown that celecoxib prevents the development of gastric cancer.	Celecoxib	80-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-108
17323186-3	2007	Several animal and clinical studies have reported the chemopreventive effect of celecoxib, a selective COX-2 inhibitor; and in particular, a few studies have shown that celecoxib prevents the development of gastric cancer.	Celecoxib	169-178	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-108
17225908-1	2007	Ferrocene carboxamide, FcCONH(2), forms homo- and heteroleptic complexes with Co(II), Ni(II) and Cu(II) via coordination of its carbonyl group.	fcconh(2)	23-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-84
17189672-3	2007	In eight healthy subjects, a freeze lesion was induced and mechanical pain thresholds (MPT) were tested for 5h following administration of the non-selective COX inhibitor diclofenac (75mg), the COX-2-selective inhibitor parecoxib (40mg) or placebo in a randomized, double-blind cross-over study.	parecoxib	220-229	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	194-199
17131340-3	2007	Here the authors report the synthesis and biological activity of a novel COX-2 inhibitor, FPA-306, and its effects on PC cells with different levels of COX-2 expression.	fpa	90-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-157
17131340-8	2007	The molecular modeling of FPA-306 in the COX-2 active site showed that FPA-306 is potentially able to inhibit the activity of enzyme by blocking the active site, thereby resulting in decreased PGE(2) production.	fpa	26-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-46
17131340-8	2007	The molecular modeling of FPA-306 in the COX-2 active site showed that FPA-306 is potentially able to inhibit the activity of enzyme by blocking the active site, thereby resulting in decreased PGE(2) production.	fpa	71-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-46
17131340-8	2007	The molecular modeling of FPA-306 in the COX-2 active site showed that FPA-306 is potentially able to inhibit the activity of enzyme by blocking the active site, thereby resulting in decreased PGE(2) production.	Prostaglandins E	193-196	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-46
17140667-1	2007	One new binuclear Co(II) complex of N,N,N",N"-tetrakis(2-benzimidazolylmethyl)-2-hydroxyl-1,3-diaminopropane (HL), [Co(2)L(mu(2)-Cl)](ClO(4))(2) x 3CH(3)CN x C(2)H(5)OC(2)H(5) (1), has been synthesized and its crystal structure and magnetic properties are shown.	co(2)l(mu(2)-cl)]	116-133	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-24
17140667-1	2007	One new binuclear Co(II) complex of N,N,N",N"-tetrakis(2-benzimidazolylmethyl)-2-hydroxyl-1,3-diaminopropane (HL), [Co(2)L(mu(2)-Cl)](ClO(4))(2) x 3CH(3)CN x C(2)H(5)OC(2)H(5) (1), has been synthesized and its crystal structure and magnetic properties are shown.	perchlorate	134-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-24
17140667-2	2007	In 1, each Co(II) atom has a distorted trigonal bipyramidal geometry with a N(3)OCl donor set.	n(3)ocl	76-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-17
17299624-1	2007	The triazine derived ligand reacts with one equivalent of Co(II) salts to give complexes whose architecture depends on the solvent employed: the [2 x 2]-grid like tetranuclear complex and the pincer-like mononuclear complex, obtained respectively by crystallization from nitromethane and from acetonitrile may be interconverted reversibly, the grid-pincer conversion being markedly accelerated by adding an amine.	Triazines	4-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-64
17207548-1	2007	PURPOSE: To evaluate the potential radiosensitizing effect of the specific COX-2 inhibitor celecoxib (Celebrex) on prostate carcinoma cells in vitro.	Celecoxib	91-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
17207548-1	2007	PURPOSE: To evaluate the potential radiosensitizing effect of the specific COX-2 inhibitor celecoxib (Celebrex) on prostate carcinoma cells in vitro.	Celecoxib	102-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
17207548-3	2007	Western blot analysis and ELISA were used to determine the impact of radiation alone or radiation combined with celecoxib treatment on COX-2 expression and prostaglandin E2 synthesis.	Celecoxib	112-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-140
17207548-7	2007	Treatment with celecoxib alone or in combination with IR led to a dose-dependent increase in COX-2 protein expression.	Celecoxib	15-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-98
17213928-1	2007	Fe(II), Co(II), Ni(II) and Cu(II) complexes based on the triazine ligand 2,4-di(2"-pyridyl)-6-(p-bromo-phenyl)-1,3,5-triazine have been synthesised and characterised.	Triazines	57-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	8-14
17213928-1	2007	Fe(II), Co(II), Ni(II) and Cu(II) complexes based on the triazine ligand 2,4-di(2"-pyridyl)-6-(p-bromo-phenyl)-1,3,5-triazine have been synthesised and characterised.	2,4-di(2"-pyridyl)-6-(p-bromo-phenyl)-1,3,5-triazine	73-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	8-14
17386512-1	2007	Silver solid amalgam electrode (AgSAE) was used for differential pulse voltammetric (DPV) measurements of cysteine and cysteine-containing peptides, glutathione, gamma-Glu-Cys-Gly and phytochelatin (gamma-Glu-Cys)(3)-Gly (PC3), in the presence of Co(II) ions.	Silver	0-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	247-253
17299624-1	2007	The triazine derived ligand reacts with one equivalent of Co(II) salts to give complexes whose architecture depends on the solvent employed: the [2 x 2]-grid like tetranuclear complex and the pincer-like mononuclear complex, obtained respectively by crystallization from nitromethane and from acetonitrile may be interconverted reversibly, the grid-pincer conversion being markedly accelerated by adding an amine.	nitromethane	271-283	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-64
17299624-1	2007	The triazine derived ligand reacts with one equivalent of Co(II) salts to give complexes whose architecture depends on the solvent employed: the [2 x 2]-grid like tetranuclear complex and the pincer-like mononuclear complex, obtained respectively by crystallization from nitromethane and from acetonitrile may be interconverted reversibly, the grid-pincer conversion being markedly accelerated by adding an amine.	acetonitrile	293-305	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-64
17299624-1	2007	The triazine derived ligand reacts with one equivalent of Co(II) salts to give complexes whose architecture depends on the solvent employed: the [2 x 2]-grid like tetranuclear complex and the pincer-like mononuclear complex, obtained respectively by crystallization from nitromethane and from acetonitrile may be interconverted reversibly, the grid-pincer conversion being markedly accelerated by adding an amine.	Amines	407-412	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-64
17299639-1	2007	The first paramagnetic homo- and hetero-metallic trinuclear complexes with redox active ligands derived from TTF are synthesized, the central metal ion has an octahedral coordination sphere while the outer Co(II) ions are in a distorted bipyramidal surrounding, bearing TTF-ligands, the magnetic properties show antiferromagnetic coupling leading to a magnetic ground state.	Metals	40-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	206-212
17046175-10	2007	These results suggest that IL-1beta-induced catabolic action on tendon fibroblasts occurs via the upregulation of two key inflammatory mediators, cPLA(2) and COX-2, which are responsible for the synthesis of PGE(2).	Prostaglandins E	208-211	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	158-163
17067801-2	2007	Structure-activity relationship (SAR) studies showed that compounds having a neutral (H), or electronegative halogen (F, Cl, Br), substituent at the para-position of the C-3 phenyl ring inhibited both COX-1 and COX-2 with COX-2 selectivity indexes in the 3.1-39.4 range.	Halogens	109-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	211-216
17067801-2	2007	Structure-activity relationship (SAR) studies showed that compounds having a neutral (H), or electronegative halogen (F, Cl, Br), substituent at the para-position of the C-3 phenyl ring inhibited both COX-1 and COX-2 with COX-2 selectivity indexes in the 3.1-39.4 range.	Halogens	109-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	222-227
17067801-4	2007	These SAR data indicate the 3-aryl-4-(4-methylsulfonamidophenyl)-2(5H)furanone scaffold provides a suitable template to design COX inhibitors with variable COX-2 selectivity indexes.	3-aryl-4-(4-methylsulfonamidophenyl)-2(5h)furanone	28-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	156-161
19071279-1	2007	In this work, 1,10-phenanthroline was used as a complexing agent for the separation and preconcentration of Cd(II), Co(II), Ni(II), Cu(II) and Pb(II) on activated carbon.	1,10-phenanthroline	14-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-122
19071279-1	2007	In this work, 1,10-phenanthroline was used as a complexing agent for the separation and preconcentration of Cd(II), Co(II), Ni(II), Cu(II) and Pb(II) on activated carbon.	Carbon	163-169	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-122
19071279-4	2007	The desorption was found quantitative with 8mol dm(-3) HNO(3) for Cd(II) (92.6%), Co(II) (95.6%), Pb(II) (91.0%), and with 3mol dm(-3) HNO(3) for Cd(II) (95.4%), Pb(II) (100.2%).	dm	48-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-88
17404070-0	2007	Possible link between NO concentrations and COX-2 expression in systems treated with soy-isoflavones.	Isoflavones	89-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-49
19071321-1	2007	A solid-phase absorbent obtained by the immobilization of Aliquat 336 chloride in poly(vinyl chloride) is reported to extract preferentially Co(II) from its 7M hydrochloric acid solutions containing Ni(II).	Chlorides	70-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	141-147
19071321-1	2007	A solid-phase absorbent obtained by the immobilization of Aliquat 336 chloride in poly(vinyl chloride) is reported to extract preferentially Co(II) from its 7M hydrochloric acid solutions containing Ni(II).	Polyvinyl Chloride	82-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	141-147
19071321-1	2007	A solid-phase absorbent obtained by the immobilization of Aliquat 336 chloride in poly(vinyl chloride) is reported to extract preferentially Co(II) from its 7M hydrochloric acid solutions containing Ni(II).	Hydrochloric Acid	160-177	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	141-147
19071321-1	2007	A solid-phase absorbent obtained by the immobilization of Aliquat 336 chloride in poly(vinyl chloride) is reported to extract preferentially Co(II) from its 7M hydrochloric acid solutions containing Ni(II).	Nickel(2+)	199-205	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	141-147
19071321-3	2007	Co(II) was rapidly and quantitatively back-extracted with deionised water.	Water	68-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
19071321-4	2007	A mechanism for the extraction of Co(II) is proposed based on the formation of the ion-pair A(+)[HCoCl(4)](-) where A(+) is the Aliquat 336 cation.	hcocl	97-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-39
19071321-5	2007	Fe(III) and Cd(II), usually present in Co(II) and Ni(II) samples, were also extracted into the solid-phase absorbent though at a slower rate than Co(II) and they did not interfere with the separation of Co(II) from Ni(II).	ferric sulfate	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-45
19071321-5	2007	Fe(III) and Cd(II), usually present in Co(II) and Ni(II) samples, were also extracted into the solid-phase absorbent though at a slower rate than Co(II) and they did not interfere with the separation of Co(II) from Ni(II).	cd(ii)	12-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-45
17204142-0	2007	All-trans retinoic acid induces COX-2 and prostaglandin E2 synthesis in SH-SY5Y human neuroblastoma cells: involvement of retinoic acid receptors and extracellular-regulated kinase 1/2.	Tretinoin	10-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-37
17204142-3	2007	Since ATRA also up-regulated COX-2 expression in SH-SY5Y human neuroblastoma cells, the current study was undertaken to analyze in these cells the mechanism through which ATRA increases COX activity.	Tretinoin	6-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34
17204142-10	2007	RESULTS: ATRA induced a significant increase of COX-2 expression in a dose- and time-dependent manner in SH-SY5Y human neuroblastoma cells, while COX-1 expression remained unchanged.	Tretinoin	9-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-53
17204142-12	2007	Up-regulation of COX-2 protein expression was followed by increased production of PGE2.	Dinoprostone	82-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22
17204142-15	2007	Pre-incubation of SH-SY5Y human neuroblastoma cells with either RAR-pan-antagonist LE540 or MAP kinase kinase 1 (MEK-1) inhibitor PD98059 resulted in the abolition of ATRA-induced COX-2 promoter activity, COX-2 protein expression and PGE2 production whereas the retinoid X receptor pan-antagonist HX531, the p38 MAPK inhibitor SB203580 or the c-Jun kinase inhibitor SP600125 did not have any effect.	LE 540	83-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	180-185
17204142-15	2007	Pre-incubation of SH-SY5Y human neuroblastoma cells with either RAR-pan-antagonist LE540 or MAP kinase kinase 1 (MEK-1) inhibitor PD98059 resulted in the abolition of ATRA-induced COX-2 promoter activity, COX-2 protein expression and PGE2 production whereas the retinoid X receptor pan-antagonist HX531, the p38 MAPK inhibitor SB203580 or the c-Jun kinase inhibitor SP600125 did not have any effect.	LE 540	83-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	205-210
17204142-15	2007	Pre-incubation of SH-SY5Y human neuroblastoma cells with either RAR-pan-antagonist LE540 or MAP kinase kinase 1 (MEK-1) inhibitor PD98059 resulted in the abolition of ATRA-induced COX-2 promoter activity, COX-2 protein expression and PGE2 production whereas the retinoid X receptor pan-antagonist HX531, the p38 MAPK inhibitor SB203580 or the c-Jun kinase inhibitor SP600125 did not have any effect.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	130-137	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	180-185
17204142-15	2007	Pre-incubation of SH-SY5Y human neuroblastoma cells with either RAR-pan-antagonist LE540 or MAP kinase kinase 1 (MEK-1) inhibitor PD98059 resulted in the abolition of ATRA-induced COX-2 promoter activity, COX-2 protein expression and PGE2 production whereas the retinoid X receptor pan-antagonist HX531, the p38 MAPK inhibitor SB203580 or the c-Jun kinase inhibitor SP600125 did not have any effect.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	130-137	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	205-210
17204142-15	2007	Pre-incubation of SH-SY5Y human neuroblastoma cells with either RAR-pan-antagonist LE540 or MAP kinase kinase 1 (MEK-1) inhibitor PD98059 resulted in the abolition of ATRA-induced COX-2 promoter activity, COX-2 protein expression and PGE2 production whereas the retinoid X receptor pan-antagonist HX531, the p38 MAPK inhibitor SB203580 or the c-Jun kinase inhibitor SP600125 did not have any effect.	Tretinoin	167-171	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	180-185
17204142-15	2007	Pre-incubation of SH-SY5Y human neuroblastoma cells with either RAR-pan-antagonist LE540 or MAP kinase kinase 1 (MEK-1) inhibitor PD98059 resulted in the abolition of ATRA-induced COX-2 promoter activity, COX-2 protein expression and PGE2 production whereas the retinoid X receptor pan-antagonist HX531, the p38 MAPK inhibitor SB203580 or the c-Jun kinase inhibitor SP600125 did not have any effect.	Tretinoin	167-171	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	205-210
17204142-17	2007	CONCLUSION: These results highlight the importance of RAR-dependent and kinase-dependent mechanisms for ATRA-induced COX-2 expression and activity.	Tretinoin	104-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-122
17197641-3	2007	Therefore, we used a COX-2 inhibitor to test the hypothesis that PG-mediated pyrogenicity may contribute to the raised T(body) in exercising humans.	pg	65-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-26
17197641-11	2007	COX-2 specific NSAID lowered exercising heat and cardiovascular strain and the sweating (offset) threshold, independently of heat production, indicating that PGE-mediated inflammatory processes may contribute to exercising heat strain during endurance exercise in humans.	Prostaglandins E	158-161	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
17404070-10	2007	The COX-2 stimulatory effect of soy-isoflavones appeared to be modulated by ERK-1 and -2 and p38.	Isoflavones	32-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
17404070-11	2007	In mammalian cancer system, incubation with the NO donor sodium nitroprusside (SNP) resulted in a slight upregulation of COX-2, and cotreatment with genistein decreased COX-2 expression possibly by the activation of AMP-activated protein kinase (AMPK).	Nitroprusside	57-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-126
17404070-11	2007	In mammalian cancer system, incubation with the NO donor sodium nitroprusside (SNP) resulted in a slight upregulation of COX-2, and cotreatment with genistein decreased COX-2 expression possibly by the activation of AMP-activated protein kinase (AMPK).	Nitroprusside	57-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	169-174
17404070-11	2007	In mammalian cancer system, incubation with the NO donor sodium nitroprusside (SNP) resulted in a slight upregulation of COX-2, and cotreatment with genistein decreased COX-2 expression possibly by the activation of AMP-activated protein kinase (AMPK).	Genistein	149-158	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-126
17404070-11	2007	In mammalian cancer system, incubation with the NO donor sodium nitroprusside (SNP) resulted in a slight upregulation of COX-2, and cotreatment with genistein decreased COX-2 expression possibly by the activation of AMP-activated protein kinase (AMPK).	Genistein	149-158	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	169-174
17244362-8	2007	The selective COX-2 inhibitor N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide (NS398) significantly reduced 27-hydroxylase and ABCA1 message (to 62.4% +/- 2.2% and 71.1% +/- 3.9% of control, respectively).	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	30-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
16763290-6	2007	A COX-1 inhibitor decreased partially the tonic contraction and TxB2 (TxA2 stable metabolite) levels; a COX-2 inhibitor lowered the tonic contraction partially and reduced PGE2 levels.	Dinoprostone	172-176	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
16763290-8	2007	Transfection of human GB muscle strips with COX-1 siRNA partially lowered the tonic contraction and reduced COX-1 protein expression and TxB2 levels; COX-2 siRNA also partially reduced the tonic contraction, the protein expression of COX-2, and PGE2.	Dinoprostone	245-249	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	150-155
16763290-11	2007	We conclude that PGE2 generated by COX-2 and TxA2 generated by COX-1 contributes to the maintenance of GB tonic contraction and that variations in tonic contraction are associated with concomitant changes in PGE2 and TxA2 levels.	Dinoprostone	17-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40
17244362-8	2007	The selective COX-2 inhibitor N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide (NS398) significantly reduced 27-hydroxylase and ABCA1 message (to 62.4% +/- 2.2% and 71.1% +/- 3.9% of control, respectively).	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	83-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
17202660-0	2007	Tetrandrine inhibits proinflammatory cytokines, iNOS and COX-2 expression in human monocytic cells.	tetrandrine	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-62
17014826-3	2007	EGCG enhanced cyclooxygenase (COX)-2 and mPGES-1 gene expression as well as PGE(2).	epigallocatechin gallate	0-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-36
17100552-2	2007	However, the adverse gastrointestinal and cardiovascular side effects associated with NSAIDs and COX-2 selective inhibitors (coxibs) have provoked more scrutiny of the precise role of specific downstream mediators in the prostaglandin (PG) signaling cascade.	Prostaglandins	221-234	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
17202660-2	2007	In this study, our aim was to examine the anti-inflammatory mechanism of TET through measuring the inducible nitric oxide synthase (iNOS), cyclooxygenase-1, and -2 (COX-1 and COX-2) expression, cytokines (TNF-alpha, IL-4 and IL-8) formation, nitric oxide (NO) release and prostaglandin E2 (PGE2) generation in lipopolysaccharide (LPS)-induced human monocytic (THP-1) cells.	tetrandrine	73-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	175-180
17100552-6	2007	We review the emerging molecular mechanisms by which COX-2-derived PGE(2) is involved in cancer progression and delineate potential opportunities for development of novel pharmacologic approaches utilizing this pathway.	Dinoprostone	67-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-58
17663446-3	2007	Metal ion-induced self-assembly of 1,4-bis(2,2":6",2""-terpyridin-4"-yl)benzene with Fe(II) or Co(II) results in MEPEs with interesting electrochemical properties.	Metals	0-5	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-101
17214885-2	2007	The enzyme responsible for the conversion of arachidonic acid to prostaglandins in response to inflammation is prostaglandin endoperoxide synthase 2/cyclo-oxygenase 2 (PTGS2/COX2).	Arachidonic Acid	45-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	174-178
17214885-2	2007	The enzyme responsible for the conversion of arachidonic acid to prostaglandins in response to inflammation is prostaglandin endoperoxide synthase 2/cyclo-oxygenase 2 (PTGS2/COX2).	Prostaglandins	65-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	174-178
17202660-5	2007	Furthermore, TET at 100 microM significantly blocked the LPS induction of iNOS and COX-2 expression, but not the COX-1.	tetrandrine	13-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
17663446-3	2007	Metal ion-induced self-assembly of 1,4-bis(2,2":6",2""-terpyridin-4"-yl)benzene with Fe(II) or Co(II) results in MEPEs with interesting electrochemical properties.	1,4-bis(2,2":6",2""-terpyridin-4"-yl)benzene	35-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-101
17584067-6	2007	In this article, we review the pattern of expression of COX-2 in the cellular players of atherothrombosis, its role as a determinant of plaque vulnerability, the effects of the variable expression of upstream and downstream enzymes in the prostanoid biosynthesis on COX-2 expression and inhibition.	Prostaglandins	239-249	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-61
17691997-2	2007	Etoricoxib and lumiracoxib are regarded as second generation coxibs because of their higher COX-2 selectivity.	Etoricoxib	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-97
17691954-1	2007	Prostacyclin (PGI(2)) is a major product of COX-2 catalyzed metabolism of arachidonic acid in the endothelium.	Epoprostenol	0-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-49
17691954-1	2007	Prostacyclin (PGI(2)) is a major product of COX-2 catalyzed metabolism of arachidonic acid in the endothelium.	Epoprostenol	14-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-49
17691954-1	2007	Prostacyclin (PGI(2)) is a major product of COX-2 catalyzed metabolism of arachidonic acid in the endothelium.	Arachidonic Acid	74-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-49
17691997-2	2007	Etoricoxib and lumiracoxib are regarded as second generation coxibs because of their higher COX-2 selectivity.	lumiracoxib	15-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-97
17305567-0	2007	COX-2 inhibitors celecoxib and parecoxib: valuable options for postoperative pain management.	Celecoxib	17-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
18220787-1	2007	Cyclooxygenases (COXs), the enzymes involved in the formation of prostaglandins from polyunsaturated fatty acids such as arachidonic acid, exist in two forms--the constitutive COX-1 that is cytoprotective and responsible for the production of prostaglandins and COX-2 which is induced by cytokines, mitogens and endotoxins in inflammatory cells and responsible for the increased levels of prostaglandins during inflammation.	Prostaglandins	65-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	262-267
18220787-1	2007	Cyclooxygenases (COXs), the enzymes involved in the formation of prostaglandins from polyunsaturated fatty acids such as arachidonic acid, exist in two forms--the constitutive COX-1 that is cytoprotective and responsible for the production of prostaglandins and COX-2 which is induced by cytokines, mitogens and endotoxins in inflammatory cells and responsible for the increased levels of prostaglandins during inflammation.	Fatty Acids, Unsaturated	85-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	262-267
18220787-1	2007	Cyclooxygenases (COXs), the enzymes involved in the formation of prostaglandins from polyunsaturated fatty acids such as arachidonic acid, exist in two forms--the constitutive COX-1 that is cytoprotective and responsible for the production of prostaglandins and COX-2 which is induced by cytokines, mitogens and endotoxins in inflammatory cells and responsible for the increased levels of prostaglandins during inflammation.	Arachidonic Acid	121-137	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	262-267
17305567-0	2007	COX-2 inhibitors celecoxib and parecoxib: valuable options for postoperative pain management.	parecoxib	31-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
17305569-8	2007	Indeed, both COX-2 and 5-LOX are also involved in the development and progression of several types of cancer; in these conditions, selective inhibition of COX-2 alone may lead to a shunt of arachidonic acid metabolism towards the leukotriene pathway, and therefore the blockade of both COX-2 and 5-LOX may produce a better anticancer response.	Arachidonic Acid	190-206	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-24
17305569-8	2007	Indeed, both COX-2 and 5-LOX are also involved in the development and progression of several types of cancer; in these conditions, selective inhibition of COX-2 alone may lead to a shunt of arachidonic acid metabolism towards the leukotriene pathway, and therefore the blockade of both COX-2 and 5-LOX may produce a better anticancer response.	Arachidonic Acid	190-206	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
17305569-8	2007	Indeed, both COX-2 and 5-LOX are also involved in the development and progression of several types of cancer; in these conditions, selective inhibition of COX-2 alone may lead to a shunt of arachidonic acid metabolism towards the leukotriene pathway, and therefore the blockade of both COX-2 and 5-LOX may produce a better anticancer response.	Arachidonic Acid	190-206	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	286-297
17305569-8	2007	Indeed, both COX-2 and 5-LOX are also involved in the development and progression of several types of cancer; in these conditions, selective inhibition of COX-2 alone may lead to a shunt of arachidonic acid metabolism towards the leukotriene pathway, and therefore the blockade of both COX-2 and 5-LOX may produce a better anticancer response.	Leukotrienes	230-241	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-24
17305569-8	2007	Indeed, both COX-2 and 5-LOX are also involved in the development and progression of several types of cancer; in these conditions, selective inhibition of COX-2 alone may lead to a shunt of arachidonic acid metabolism towards the leukotriene pathway, and therefore the blockade of both COX-2 and 5-LOX may produce a better anticancer response.	Leukotrienes	230-241	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
17305573-7	2007	In 1991, it was discovered that COX exists in two distinct isozymes, COX-1 and COX-2, of which COX-2 is primarily expressed at sites of inflammation and produces pro-inflammatory eicosanoids.	Eicosanoids	179-190	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-84
17305573-7	2007	In 1991, it was discovered that COX exists in two distinct isozymes, COX-1 and COX-2, of which COX-2 is primarily expressed at sites of inflammation and produces pro-inflammatory eicosanoids.	Eicosanoids	179-190	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-100
17202660-6	2007	Taken together, these results suggest that TET exerts anti-inflammatory effects probably through the suppression of COX-2 and iNOS expression.	tetrandrine	43-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-121
17305573-9	2007	Recently, some COX-2 selective inhibitors have shown adverse cardiovascular side effects, resulting in the withdrawal of rofecoxib and valdecoxib from the market.	rofecoxib	121-130	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-20
17305573-9	2007	Recently, some COX-2 selective inhibitors have shown adverse cardiovascular side effects, resulting in the withdrawal of rofecoxib and valdecoxib from the market.	valdecoxib	135-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-20
17305573-10	2007	Selective inhibition of COX-2 without reducing COX-1-mediated thromboxane production could alter the balance between prostacyclin and thromboxane and promote a prothrombotic state, thereby explaining the observed COX-2 cardiovascular risk.	Epoprostenol	117-129	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
17305573-10	2007	Selective inhibition of COX-2 without reducing COX-1-mediated thromboxane production could alter the balance between prostacyclin and thromboxane and promote a prothrombotic state, thereby explaining the observed COX-2 cardiovascular risk.	Thromboxanes	134-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
17428102-3	2007	COX-2 is an enzyme induced in pathological states such as inflammatory disorders and cancer, where it mediates production of prostanoids.	Prostaglandins	125-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
17192482-4	2007	Perifusion experiments with human islets indicated that PLA(2) inhibition inhibited glucose-stimulated insulin secretion, whereas inhibitors of COX-2 and 12-LOX enzymes enhanced basal insulin secretion and also secretory responses induced by 20 mmol/l glucose or by 50 mumol/l arachidonic acid.	Glucose	252-259	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	144-149
17192482-7	2007	The products of COX-2 and LOX activities have been implicated in cytokine-mediated damage of beta-cells, so selective inhibitors of these enzymes would be expected to have a dual protective role in diabetes: they would minimize beta-cell dysfunction while maintaining insulin secretion through enhancing endogenous arachidonic acid levels.	Arachidonic Acid	315-331	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-21
17428102-11	2007	This review discusses the role of COX-2, its products (prostaglandins) and its inhibitors in tumour growth and treatment.	Prostaglandins	55-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-39
17097285-2	2007	In the present study, we show that the specific COX-2 inhibitor celecoxib enhances the inhibitory effect of doxorubicin (dox) on human MDA-MB231 breast tumour growth in vivo and in vitro.	Celecoxib	64-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-53
17097285-2	2007	In the present study, we show that the specific COX-2 inhibitor celecoxib enhances the inhibitory effect of doxorubicin (dox) on human MDA-MB231 breast tumour growth in vivo and in vitro.	Doxorubicin	108-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-53
17097285-2	2007	In the present study, we show that the specific COX-2 inhibitor celecoxib enhances the inhibitory effect of doxorubicin (dox) on human MDA-MB231 breast tumour growth in vivo and in vitro.	Doxorubicin	108-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-53
17097285-4	2007	Since the NSAID indomethacin and the specific COX-2 inhibitor NS398 did not affect the in vitro actions of dox, these effects are likely to be mediated via a COX-independent mechanism.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	62-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
17143555-0	2007	MAP kinase subtypes and Akt regulate diosgenin-induced apoptosis of rheumatoid synovial cells in association with COX-2 expression and prostanoid production.	Diosgenin	37-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-119
17127241-5	2007	It is only logical then, that future clinical studies should focus on examining the efficacy of phytochemicals such as EGCG in cancer chemoprevention as an alternative to pharmacological agents, especially in populations where administration of COX-2 inhibitors, Aspirin and NSAIDS is contraindicated.	epigallocatechin gallate	119-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	245-250
17127267-5	2007	Recent findings indicate that low concentrations of ethanol (10 mM) promote inflammatory processes in brain and in glial cells by up-regulating cytokines and inflammatory mediators (iNOS, NO, COX-2), and by activating signaling pathways (IKK, MAPKs) and transcriptional factors (NF-kappaB, AP-1) implicated in inflammatory injury.	Ethanol	52-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	192-197
17187424-9	2007	These findings suggest that COX-2-derived PGs may have great therapeutic potentials in treating patients with inflammatory liver diseases.	Phosphatidylglycerols	42-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
17016059-2	2007	BACKGROUND: The anti-inflammatory actions of acetylsalicylic acid (ASA)/non-steroidal anti-inflammatory drugs (NSAIDs) are thought to be due to inhibition of COX-2, whereas the side effects such as gastric damage and aspirin-induced asthma are mediated through inhibition of COX-1.	Aspirin	45-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	158-163
17016059-2	2007	BACKGROUND: The anti-inflammatory actions of acetylsalicylic acid (ASA)/non-steroidal anti-inflammatory drugs (NSAIDs) are thought to be due to inhibition of COX-2, whereas the side effects such as gastric damage and aspirin-induced asthma are mediated through inhibition of COX-1.	Aspirin	67-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	158-163
17016059-3	2007	Therefore, a new class of drugs with COX-2 selectivity may be well tolerated by patients with ASA/NSAIDs hypersensitivity.	Aspirin	94-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-42
17457030-2	2007	Since nonsteroidal anti-inflammatory drugs inhibit cyclooxygenase (COX), COX-2, an inducible form of COX, may be involved in the pathology of AD in association with the arachidonic acid cascade.	Arachidonic Acid	169-185	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-78
17143555-1	2007	In the present study, we investigated the signalling pathways involved in diosgenin-induced apoptosis in human rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS) in vitro with particular interest on Akt and MAPKs activation in relation to arachidonic acid metabolism via COX-2 pathway.	Diosgenin	74-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	281-286
17504133-4	2007	This observation led to the development of COX-2 inhibitors or "coxibs" of which rofecoxib (Vioxx) characterized by a methylsulfone moiety and the sulfonamides celecoxib (Celebrex) and valdecoxib (Bextra).	rofecoxib	81-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
17504133-4	2007	This observation led to the development of COX-2 inhibitors or "coxibs" of which rofecoxib (Vioxx) characterized by a methylsulfone moiety and the sulfonamides celecoxib (Celebrex) and valdecoxib (Bextra).	rofecoxib	92-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
17504133-5	2007	Initially described as COX-2 "selective" inhibitors, recent reports revealed a nanomolar inhibition activity of the sulfonamide COX-2 inhibitors for several carbonic anhydrase (CA) isoforms, confirmed by X-ray crystal structures for the adducts of celecoxib and valdecoxib with isozyme CA II.	Celecoxib	248-257	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	128-133
17143555-5	2007	The prostanoid production (COX-2 activity) was measured by quantitative ELISA.	Prostaglandins	4-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-32
17143555-10	2007	Diosgenin increased COX-2 activity resulting in PGE2 and 6-keto-PGF1alpha overproduction in human RA FLS.	Dinoprostone	48-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-25
17143555-10	2007	Diosgenin increased COX-2 activity resulting in PGE2 and 6-keto-PGF1alpha overproduction in human RA FLS.	6-Ketoprostaglandin F1 alpha	57-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-25
17143555-12	2007	These results provide, for the first time, strong evidence that a combined association implicating a MEK inhibitor (U0126) and diosgenin is the most effective in inducing very strong apoptosis with down-regulation of COX-2 expression and activity in human RA FLS.	U 0126	116-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	217-222
17143555-12	2007	These results provide, for the first time, strong evidence that a combined association implicating a MEK inhibitor (U0126) and diosgenin is the most effective in inducing very strong apoptosis with down-regulation of COX-2 expression and activity in human RA FLS.	Diosgenin	127-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	217-222
17143540-5	2007	Dideoxypetrosynol A decreased the levels of cyclooxygenase (COX)-2 mRNA and protein expression without significant changes in the levels of COX-1, which was correlated with a decrease in prostaglandin E2 (PGE2) synthesis.	dideoxypetrosynol A	0-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-66
17075897-5	2007	The LPS-induced release of PGE(2) was depressed by a selective COX-2 inhibitor, NS-398.	Dinoprostone	27-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-68
17678966-7	2007	The induction of COX-2 was paralleled by a substantial raise in the brain homogenate PGE(2) levels.	Dinoprostone	85-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22
17075897-5	2007	The LPS-induced release of PGE(2) was depressed by a selective COX-2 inhibitor, NS-398.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	80-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-68
17555881-2	2007	The ideas about rofecoxib trials stem from a different paradigm to explain COX-2 inhibitor (coxib)-induced myocardial infarctions.	rofecoxib	16-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
17627037-11	2007	The antioxidant pyrrolidine dithiocarbamate inhibited COX-2 protein expression and COX-2 transcriptional activity induced by gp120.	pyrrolidine dithiocarbamic acid	16-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-59
17222987-0	2007	A pathogenetic mechanism for COX-2 inhibitor-induced cardiovascular events proposed to be useful in structuring medical testimony in rofecoxib trials.	rofecoxib	133-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34
17289285-10	2007	One hypothesis for a mechanism of action is that a precursor (COX-2) or metabolite of prostaglandins causes menstrual cramping and not prostaglandins themselves.	Prostaglandins	86-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
17954230-3	2007	Through the action of COX-2 and downstream prostaglandin synthases, a diverse family of prostaglandin glycerol esters (PG-Gs) and prostaglandin ethanolamides (PG-EAs) have been identified.	prostaglandin glycerol esters	88-117	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-27
17954230-3	2007	Through the action of COX-2 and downstream prostaglandin synthases, a diverse family of prostaglandin glycerol esters (PG-Gs) and prostaglandin ethanolamides (PG-EAs) have been identified.	pg-gs	119-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-27
17954230-3	2007	Through the action of COX-2 and downstream prostaglandin synthases, a diverse family of prostaglandin glycerol esters (PG-Gs) and prostaglandin ethanolamides (PG-EAs) have been identified.	prostaglandin ethanolamides	130-157	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-27
17954230-3	2007	Through the action of COX-2 and downstream prostaglandin synthases, a diverse family of prostaglandin glycerol esters (PG-Gs) and prostaglandin ethanolamides (PG-EAs) have been identified.	pg-eas	159-165	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-27
17627037-11	2007	The antioxidant pyrrolidine dithiocarbamate inhibited COX-2 protein expression and COX-2 transcriptional activity induced by gp120.	pyrrolidine dithiocarbamic acid	16-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
17927497-5	2007	Preferentially, Cox-2 inhibition can create a favorable pattern of cytokines by decreasing the production of certain eicosanoids, although their role in SIMS is unknown.	Eicosanoids	117-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-21
17961045-2	2007	Enzymes of the arachidonic acid (AA) cascade such as cyclooxygenase (COX)-2 or 5-lipoxygenase (5-LO) are upregulated in a number of epithelial tumors, but to date there are hardly any data about the expression of these markers in meningiomas.	Arachidonic Acid	15-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-75
17961045-9	2007	CONCLUSIONS: Eicosanoid derivatives COX-1, COX-2, 5-LO, and PTGER4 enzymes show a high universal expression in meningiomas but are not upregulated in normal human cortex and dura tissue.	Eicosanoids	13-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
17164136-4	2007	In contrast, the tNSAIDs meloxicam, nimesulide and diclofenac (which are from 18- to 29-fold more potent towards COX-2 in vitro) and coxibs (i.e. celecoxib, valdecoxib, rofecoxib, etoricoxib and lumiracoxib, which are from 30- to 433-fold more potent towards COX-2 in vitro) should be comprised into the cluster of COX-2 inhibitors.	Meloxicam	25-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-118
17159378-1	2007	All-trans retinoic acid (ATRA) increases the expression of COX-1 and COX-2 and the production of PGE2, a prostaglandin with anti-inflammatory effects in human mesangial cells (MC).	Tretinoin	0-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-74
17159378-1	2007	All-trans retinoic acid (ATRA) increases the expression of COX-1 and COX-2 and the production of PGE2, a prostaglandin with anti-inflammatory effects in human mesangial cells (MC).	Tretinoin	25-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-74
18605234-14	2007	Considering the cardiovascular effects of COX-2 selective inhibitors, the combination of diclofenac and misoprostol could represent a safer and effective alternative for patients with pain.	Diclofenac	89-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47
18605234-14	2007	Considering the cardiovascular effects of COX-2 selective inhibitors, the combination of diclofenac and misoprostol could represent a safer and effective alternative for patients with pain.	Misoprostol	104-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47
17164136-4	2007	In contrast, the tNSAIDs meloxicam, nimesulide and diclofenac (which are from 18- to 29-fold more potent towards COX-2 in vitro) and coxibs (i.e. celecoxib, valdecoxib, rofecoxib, etoricoxib and lumiracoxib, which are from 30- to 433-fold more potent towards COX-2 in vitro) should be comprised into the cluster of COX-2 inhibitors.	nimesulide	36-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-118
17164137-4	2007	Of further importance has been the world-wide withdrawal of selective COX-2 inhibitors, due to their discriminating suppression of COX-2-derived PGI2 and its cardioprotective effects, leading to increased cardiovascular events, including myocardial infarction and thrombotic stroke.	Epoprostenol	145-149	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-75
17164136-4	2007	In contrast, the tNSAIDs meloxicam, nimesulide and diclofenac (which are from 18- to 29-fold more potent towards COX-2 in vitro) and coxibs (i.e. celecoxib, valdecoxib, rofecoxib, etoricoxib and lumiracoxib, which are from 30- to 433-fold more potent towards COX-2 in vitro) should be comprised into the cluster of COX-2 inhibitors.	Diclofenac	51-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-118
17164137-4	2007	Of further importance has been the world-wide withdrawal of selective COX-2 inhibitors, due to their discriminating suppression of COX-2-derived PGI2 and its cardioprotective effects, leading to increased cardiovascular events, including myocardial infarction and thrombotic stroke.	Epoprostenol	145-149	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-136
17164136-4	2007	In contrast, the tNSAIDs meloxicam, nimesulide and diclofenac (which are from 18- to 29-fold more potent towards COX-2 in vitro) and coxibs (i.e. celecoxib, valdecoxib, rofecoxib, etoricoxib and lumiracoxib, which are from 30- to 433-fold more potent towards COX-2 in vitro) should be comprised into the cluster of COX-2 inhibitors.	Diclofenac	51-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	259-264
17164136-4	2007	In contrast, the tNSAIDs meloxicam, nimesulide and diclofenac (which are from 18- to 29-fold more potent towards COX-2 in vitro) and coxibs (i.e. celecoxib, valdecoxib, rofecoxib, etoricoxib and lumiracoxib, which are from 30- to 433-fold more potent towards COX-2 in vitro) should be comprised into the cluster of COX-2 inhibitors.	Diclofenac	51-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	259-264
17302183-5	2007	The prostaglandins produced by COX-2 promote tumor development by stimulating cell proliferation and angiogenesis and by suppressing programmed cell death and immune defense.	Prostaglandins	4-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-36
17504133-5	2007	Initially described as COX-2 "selective" inhibitors, recent reports revealed a nanomolar inhibition activity of the sulfonamide COX-2 inhibitors for several carbonic anhydrase (CA) isoforms, confirmed by X-ray crystal structures for the adducts of celecoxib and valdecoxib with isozyme CA II.	valdecoxib	262-272	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	128-133
17504133-6	2007	This dual activity may help to explain differences in clinical observation between sulfonamide and methylsulfone COX-2 inhibitors.	dimethyl sulfone	99-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-118
16843053-3	2007	The number of DMF and MeOH molecules in the first solvation sphere of Co(II) ion versus solvent composition has been determined.	Dimethylformamide	14-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-76
16843053-3	2007	The number of DMF and MeOH molecules in the first solvation sphere of Co(II) ion versus solvent composition has been determined.	Methanol	22-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-76
17491148-19	2007	PGF2alpha also activates COX-2 in large luteal cells which leads to secretion of PGF2alpha.	Dinoprost	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-30
17491148-19	2007	PGF2alpha also activates COX-2 in large luteal cells which leads to secretion of PGF2alpha.	Dinoprost	81-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-30
17612044-7	2007	In the 1990"s an important discovery was made from elegant molecular and cellular biological studies that there are two cyclo-oxygenase (COX) enzyme systems controlling the production of prostanoids [prostaglandins (PGs) and thromboxane (TxA2)]; COX-1 that produces PGs and TxA2 that regulate gastrointestinal, renal, vascular and other physiological functions, and COX-2 that regulates production of PGs involved in inflammation, pain and fever.	Prostaglandins	187-198	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	366-371
17612044-7	2007	In the 1990"s an important discovery was made from elegant molecular and cellular biological studies that there are two cyclo-oxygenase (COX) enzyme systems controlling the production of prostanoids [prostaglandins (PGs) and thromboxane (TxA2)]; COX-1 that produces PGs and TxA2 that regulate gastrointestinal, renal, vascular and other physiological functions, and COX-2 that regulates production of PGs involved in inflammation, pain and fever.	Prostaglandins	200-214	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	366-371
17612044-7	2007	In the 1990"s an important discovery was made from elegant molecular and cellular biological studies that there are two cyclo-oxygenase (COX) enzyme systems controlling the production of prostanoids [prostaglandins (PGs) and thromboxane (TxA2)]; COX-1 that produces PGs and TxA2 that regulate gastrointestinal, renal, vascular and other physiological functions, and COX-2 that regulates production of PGs involved in inflammation, pain and fever.	Prostaglandins	216-219	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	366-371
17612044-7	2007	In the 1990"s an important discovery was made from elegant molecular and cellular biological studies that there are two cyclo-oxygenase (COX) enzyme systems controlling the production of prostanoids [prostaglandins (PGs) and thromboxane (TxA2)]; COX-1 that produces PGs and TxA2 that regulate gastrointestinal, renal, vascular and other physiological functions, and COX-2 that regulates production of PGs involved in inflammation, pain and fever.	Thromboxanes	225-236	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	366-371
17612044-7	2007	In the 1990"s an important discovery was made from elegant molecular and cellular biological studies that there are two cyclo-oxygenase (COX) enzyme systems controlling the production of prostanoids [prostaglandins (PGs) and thromboxane (TxA2)]; COX-1 that produces PGs and TxA2 that regulate gastrointestinal, renal, vascular and other physiological functions, and COX-2 that regulates production of PGs involved in inflammation, pain and fever.	Thromboxane A2	238-242	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	366-371
17612044-7	2007	In the 1990"s an important discovery was made from elegant molecular and cellular biological studies that there are two cyclo-oxygenase (COX) enzyme systems controlling the production of prostanoids [prostaglandins (PGs) and thromboxane (TxA2)]; COX-1 that produces PGs and TxA2 that regulate gastrointestinal, renal, vascular and other physiological functions, and COX-2 that regulates production of PGs involved in inflammation, pain and fever.	Prostaglandins	266-269	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	366-371
17612044-7	2007	In the 1990"s an important discovery was made from elegant molecular and cellular biological studies that there are two cyclo-oxygenase (COX) enzyme systems controlling the production of prostanoids [prostaglandins (PGs) and thromboxane (TxA2)]; COX-1 that produces PGs and TxA2 that regulate gastrointestinal, renal, vascular and other physiological functions, and COX-2 that regulates production of PGs involved in inflammation, pain and fever.	Thromboxane A2	274-278	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	366-371
17612044-7	2007	In the 1990"s an important discovery was made from elegant molecular and cellular biological studies that there are two cyclo-oxygenase (COX) enzyme systems controlling the production of prostanoids [prostaglandins (PGs) and thromboxane (TxA2)]; COX-1 that produces PGs and TxA2 that regulate gastrointestinal, renal, vascular and other physiological functions, and COX-2 that regulates production of PGs involved in inflammation, pain and fever.	Prostaglandins	266-269	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	366-371
17612044-9	2007	At the turn of this century, there was enormous commercial development following the introduction of two new highly selective COX-2 inhibitors, known as coxibs (celecoxib and rofecoxib) which were claimed to have low GI side effects.	Celecoxib	161-170	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-131
17612044-9	2007	At the turn of this century, there was enormous commercial development following the introduction of two new highly selective COX-2 inhibitors, known as coxibs (celecoxib and rofecoxib) which were claimed to have low GI side effects.	rofecoxib	175-184	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-131
17966896-2	2007	The main mechanism of action of NSAID is based on reducing the synthesis of prostaglandins by means of inhibiting the activity of cyclooxygenase (COX), namely, of COX-1, which generates gut protective prostaglandins, and COX-2, induced at the sites of inflammation, tissue lesions and certain neoplasm.	Prostaglandins	76-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	221-226
17966896-2	2007	The main mechanism of action of NSAID is based on reducing the synthesis of prostaglandins by means of inhibiting the activity of cyclooxygenase (COX), namely, of COX-1, which generates gut protective prostaglandins, and COX-2, induced at the sites of inflammation, tissue lesions and certain neoplasm.	Prostaglandins	201-215	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	221-226
17225893-3	2006	In addition, ligand as well as the Co(II) and Zn(II) complexes [CoCl2]2, [ZnCl2] were structurally characterized by single-crystal X-ray diffraction.	cobaltous chloride	64-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-41
17225893-3	2006	In addition, ligand as well as the Co(II) and Zn(II) complexes [CoCl2]2, [ZnCl2] were structurally characterized by single-crystal X-ray diffraction.	zinc chloride	74-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-41
16931629-4	2006	Here, we show that acute hypertensive and prothrombotic activities of the COX-2-selective inhibitor celecoxib are revealed only after in vivo inhibition of NO generation.	Celecoxib	100-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
17178883-4	2006	PPARdelta activation up-regulates the expression of cyclooxygenase (COX)-2, a rate-limiting enzyme for PG synthesis, and tumor growth.	Prostaglandins	103-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-74
17178883-8	2006	Thus, PPARdelta induces COX-2 expression and the COX-2-derived PGE(2) further activates PPARdelta via cPLA(2)alpha.	Prostaglandins E	63-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-54
17117223-3	2006	Roughened EPG electrodes coated with the Co(II)/Pt(II) bimetallic porphyrin show a catalytic shift of 500 mV for the reduction of O2 when compared to the reduction of O2 at a bare EPG electrode.	pt(ii)	48-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-47
17117223-3	2006	Roughened EPG electrodes coated with the Co(II)/Pt(II) bimetallic porphyrin show a catalytic shift of 500 mV for the reduction of O2 when compared to the reduction of O2 at a bare EPG electrode.	Porphyrins	66-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-47
17117223-3	2006	Roughened EPG electrodes coated with the Co(II)/Pt(II) bimetallic porphyrin show a catalytic shift of 500 mV for the reduction of O2 when compared to the reduction of O2 at a bare EPG electrode.	Oxygen	130-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-47
17117223-3	2006	Roughened EPG electrodes coated with the Co(II)/Pt(II) bimetallic porphyrin show a catalytic shift of 500 mV for the reduction of O2 when compared to the reduction of O2 at a bare EPG electrode.	Oxygen	167-169	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-47
17117223-5	2006	100 mV is observed for O2 reduction at an EPG electrode coated with the Co(II)/Pt(II) porphyrin which has been oxidized in 1.0 M HClO4.	Oxygen	23-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-78
17117223-5	2006	100 mV is observed for O2 reduction at an EPG electrode coated with the Co(II)/Pt(II) porphyrin which has been oxidized in 1.0 M HClO4.	pt(ii) porphyrin	79-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-78
17117223-5	2006	100 mV is observed for O2 reduction at an EPG electrode coated with the Co(II)/Pt(II) porphyrin which has been oxidized in 1.0 M HClO4.	Perchloric Acid	129-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-78
17117223-6	2006	In addition to the added electrocatalysis a significant percentage of O2 reduced at the oxidized Co(II)/Pt(II) EPG electrode is converted to H2O as determined by rotating disk electrode measurements.	Oxygen	70-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-103
17117223-6	2006	In addition to the added electrocatalysis a significant percentage of O2 reduced at the oxidized Co(II)/Pt(II) EPG electrode is converted to H2O as determined by rotating disk electrode measurements.	pt(ii)	104-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-103
17117223-6	2006	In addition to the added electrocatalysis a significant percentage of O2 reduced at the oxidized Co(II)/Pt(II) EPG electrode is converted to H2O as determined by rotating disk electrode measurements.	Water	141-144	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-103
17612053-5	2007	Selective COX-2 inhibitors (celecoxib) as well as naturally occurring anti-inflammatory agents (curcumin) have proven to be effective chemopreventive agents against colonic carcinogenesis.	Celecoxib	28-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
17628173-9	2007	The step-function difference between arylating and nonarylating tocopherol quinones is conceivably the basis for distinct biological properties of parent tocopherols, including the epigenetic modification of a histone thiol, the ceramide pathway, natriuresis, and the activity of COX-2, NF-kappaB, PPARgamma, and cyclin.	tocopherylquinone	64-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	280-285
17628173-9	2007	The step-function difference between arylating and nonarylating tocopherol quinones is conceivably the basis for distinct biological properties of parent tocopherols, including the epigenetic modification of a histone thiol, the ceramide pathway, natriuresis, and the activity of COX-2, NF-kappaB, PPARgamma, and cyclin.	Tocopherols	154-165	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	280-285
17070520-8	2006	Direct suppression of cFLIP expression by cFLIP RNAi also accelerated TRAIL-induced apoptosis in these melanomas, while COX-2 suppression substantially increased levels of both TRAIL-induced and arsenite-induced apoptosis.	arsenite	195-203	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-125
17132015-5	2006	The ligands with isopropyl groups H(4)1iPr and H(5)2iPr were combined with tris[(N"-tert-butylureayl)-N-ethyl]amine (H6buea) and bis(N-isopropylcarbamoylmethyl)amine (H(3)0iPr) to prepare a series of Co(II) complexes with varying H-bond donors.	tris((N'-tert-butylureayl)-N-ethyl)amine	75-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	200-206
16980601-5	2006	We designed a phase II study to assess the efficacy and toxicity of the combination of TMZ and celecoxib (a COX-2 inhibitor) in patients with advanced melanoma.	Temozolomide	87-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-113
16980601-5	2006	We designed a phase II study to assess the efficacy and toxicity of the combination of TMZ and celecoxib (a COX-2 inhibitor) in patients with advanced melanoma.	Celecoxib	95-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-113
17034761-5	2006	Our results demonstrated that auranofin suppressed TLR4-mediated activation of transcription factors, NF-kappaB and IRF3, and expression of COX-2, a pro-inflammatory enzyme.	Auranofin	30-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-145
17046322-6	2006	PGI(2), but not TXA(2) synthesis, was absolutely dependent on upregulation of COX-2 by hypoxia.	Epoprostenol	0-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-83
17046322-10	2006	The endothelial cell response to hypoxia involves increased production of the anti-thrombotic eicosanoid, PGI(2), which is dependent on COX-2 upregulation by a HIF-mediated process.	Epoprostenol	106-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	136-141
16904332-0	2006	5-Substituted-2,3-diphenyltetrahydrofurans: a new class of moderately selective COX-2 inhibitors.	5-substituted-2,3-diphenyltetrahydrofurans	0-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-85
16904332-1	2006	The nature of C-5 substituent and the configuration at C-5 carbon of 2,3-diphenyltetrahydrofurans, with chiral centres at C-2, C-3 and C-5, show a remarkable influence on their COX-2 inhibition and selectivity.	Carbon	59-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	177-182
16904332-1	2006	The nature of C-5 substituent and the configuration at C-5 carbon of 2,3-diphenyltetrahydrofurans, with chiral centres at C-2, C-3 and C-5, show a remarkable influence on their COX-2 inhibition and selectivity.	2,3-diphenyltetrahydrofurans	69-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	177-182
16552572-7	2006	Flavonoids were incubated with cells for 6 or 24 h and COX-2 protein expression and PGE-2 levels were assessed by Western blot and competitive immunoassay, respectively.	Flavonoids	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-60
17265571-0	2006	Pooled analysis of thrombotic cardiovascular events in clinical trials of the COX-2 selective Inhibitor etoricoxib.	Etoricoxib	104-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-83
17265571-1	2006	BACKGROUND: A pooled analysis of randomized clinical trials data was performed to compare the rate of thrombotic cardiovascular events (thrombotic events) in patients taking the COX-2 selective inhibitor (coxib) etoricoxib, a traditional NSAID, or placebo.	Etoricoxib	212-222	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	178-183
17130490-2	2006	Activated monocytes express cyclooxygenase (COX)-2, promoting prostaglandin-E(2) (PGE(2)) secretion, whereas COX-1 expression is constitutive.	Dinoprostone	62-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-50
17130490-2	2006	Activated monocytes express cyclooxygenase (COX)-2, promoting prostaglandin-E(2) (PGE(2)) secretion, whereas COX-1 expression is constitutive.	Prostaglandins E	82-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-50
17030482-5	2006	Five of them show COX-2 inhibition close to that of nimesulide and rofecoxib, two reference COX-2 selective inhibitors.	nimesulide	52-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-23
17030482-5	2006	Five of them show COX-2 inhibition close to that of nimesulide and rofecoxib, two reference COX-2 selective inhibitors.	rofecoxib	67-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-97
17213165-0	2006	Review: Selective COX 2 inhibitors increase vascular events more than placebo and naproxen but not more than other NSAIDs.	Naproxen	82-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-23
17087947-3	2006	We conducted a randomized, placebo-controlled, double-blind trial to assess whether use of the selective COX-2 inhibitor rofecoxib would reduce the risk of colorectal adenomas.	rofecoxib	121-130	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-110
17050345-7	2006	Significant inductions of IL-1beta, TNF-alpha, and Cox-1 and Cox-2 mRNA were observed following exposure to &gt; or =50 ppm acetaldehyde for 4 h. IL-6 and MCP-1 were also induced following a 4-h exposure to 500 ppm acetaldehyde.	Acetaldehyde	124-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-66
17050345-7	2006	Significant inductions of IL-1beta, TNF-alpha, and Cox-1 and Cox-2 mRNA were observed following exposure to &gt; or =50 ppm acetaldehyde for 4 h. IL-6 and MCP-1 were also induced following a 4-h exposure to 500 ppm acetaldehyde.	Acetaldehyde	215-227	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-66
16968790-12	2006	CONCLUSIONS: In sHT patients, low-grade chronic inflammation causes endothelial dysfunction and impaired nitric oxide availability by a COX-2-dependent pathway leading to increased production of oxidative stress.	Nitric Oxide	105-117	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	136-141
17122671-1	2006	OBJECTIVE: Licofelone ([2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine-5-yl]-acetic acid) has been demonstrated to inhibit cyclooxygenase (COX)-1, COX-2, and 5-lipoxygenase.	licofelone	11-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	168-173
17122671-1	2006	OBJECTIVE: Licofelone ([2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine-5-yl]-acetic acid) has been demonstrated to inhibit cyclooxygenase (COX)-1, COX-2, and 5-lipoxygenase.	licofelone	23-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	168-173
17252949-2	2006	The ligands react with Co(II), Ni(II) and Zn(II) metals to yield (1:1) and (1:2) [metal:ligand] complexes.	Metals	49-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-29
16966384-6	2006	It is reported that nicotine induces prostaglandinE2 (PGE(2)) production in PBMC through the up-regulation of cyclooxygenase (COX)-2 expression.	Nicotine	20-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-132
16966384-6	2006	It is reported that nicotine induces prostaglandinE2 (PGE(2)) production in PBMC through the up-regulation of cyclooxygenase (COX)-2 expression.	Dinoprostone	37-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-132
16966384-6	2006	It is reported that nicotine induces prostaglandinE2 (PGE(2)) production in PBMC through the up-regulation of cyclooxygenase (COX)-2 expression.	Dinoprostone	54-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-132
16966384-8	2006	Consistent with this, we found that COX-2 and PKA inhibitors prevented the effects of nicotine on adhesion molecule expression and cytokine production, indicating that the mechanism of action of nicotine may be via endogenous PGE(2) production.	Nicotine	86-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-41
16966384-8	2006	Consistent with this, we found that COX-2 and PKA inhibitors prevented the effects of nicotine on adhesion molecule expression and cytokine production, indicating that the mechanism of action of nicotine may be via endogenous PGE(2) production.	Nicotine	195-203	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-41
16966384-8	2006	Consistent with this, we found that COX-2 and PKA inhibitors prevented the effects of nicotine on adhesion molecule expression and cytokine production, indicating that the mechanism of action of nicotine may be via endogenous PGE(2) production.	Prostaglandins E	226-229	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-41
17097894-12	2006	Leptin suppresses hCG-induced PGE(2) formation through the inhibition of COX-2 and mPGES expression.	Prostaglandins E	30-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-78
16988013-2	2006	In A549 pulmonary cells, dexamethasone and the prototypical dissociated ligand RU24858 (Mol Endocrinol 11:1245-1255, 1997) repress interleukin (IL)-1beta-induced expression of cyclooxygenase (COX)-2 and IL-8.	Dexamethasone	25-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	176-198
16988013-2	2006	In A549 pulmonary cells, dexamethasone and the prototypical dissociated ligand RU24858 (Mol Endocrinol 11:1245-1255, 1997) repress interleukin (IL)-1beta-induced expression of cyclooxygenase (COX)-2 and IL-8.	RU24858	79-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	176-198
16988013-6	2006	Analysis of IL-1beta-induced steady-state mRNA levels for IL-8 and COX-2 show that dexamethasone- and RU24858-dependent repression of these genes is attenuated by inhibitors of transcription and protein synthesis.	Dexamethasone	83-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-72
17168813-6	2006	It is very well known that pain and inflammation are alleviated through the inhibition of COX-2 inhibitors such as Aspirin, which has resulted in the recent years, in the emergence of a range of COX-2 inhibitors.	Aspirin	115-122	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-95
17168813-6	2006	It is very well known that pain and inflammation are alleviated through the inhibition of COX-2 inhibitors such as Aspirin, which has resulted in the recent years, in the emergence of a range of COX-2 inhibitors.	Aspirin	115-122	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	195-200
17024689-8	2006	Recent users of COX-2 inhibitors had an increased risk of initiating antihypertensive therapy, regardless of specific drug (celecoxib adjusted OR = 1.7 (95%CI 1.3, 2.1); rofecoxib adjusted OR = 1.7 (95%CI 1.4, 1.9)).	Celecoxib	124-133	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-21
17024689-8	2006	Recent users of COX-2 inhibitors had an increased risk of initiating antihypertensive therapy, regardless of specific drug (celecoxib adjusted OR = 1.7 (95%CI 1.3, 2.1); rofecoxib adjusted OR = 1.7 (95%CI 1.4, 1.9)).	rofecoxib	170-179	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-21
17085321-0	2006	Concomitant activation of extracellular signal-regulated kinase and induction of COX-2 stimulates maximum prostaglandin E2 synthesis in human airway epithelial cells.	Dinoprostone	106-122	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-86
17085321-3	2006	Phorbol myristate acetate (PMA) and calcium ionophore, A23187 further enhanced PGE(2) synthesis (p&lt;0.001) and caused phosphorylation of ERK that was sustained for up to 16 h. COX-2 protein expression and PGE(2) synthesis were increased following exposure to combinations of stimuli that increased intracellular Ca(2+), and activated protein kinase C as well as ERK.	Tetradecanoylphorbol Acetate	0-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	178-183
17085321-3	2006	Phorbol myristate acetate (PMA) and calcium ionophore, A23187 further enhanced PGE(2) synthesis (p&lt;0.001) and caused phosphorylation of ERK that was sustained for up to 16 h. COX-2 protein expression and PGE(2) synthesis were increased following exposure to combinations of stimuli that increased intracellular Ca(2+), and activated protein kinase C as well as ERK.	Tetradecanoylphorbol Acetate	27-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	178-183
17085321-3	2006	Phorbol myristate acetate (PMA) and calcium ionophore, A23187 further enhanced PGE(2) synthesis (p&lt;0.001) and caused phosphorylation of ERK that was sustained for up to 16 h. COX-2 protein expression and PGE(2) synthesis were increased following exposure to combinations of stimuli that increased intracellular Ca(2+), and activated protein kinase C as well as ERK.	Calcium	36-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	178-183
17085321-3	2006	Phorbol myristate acetate (PMA) and calcium ionophore, A23187 further enhanced PGE(2) synthesis (p&lt;0.001) and caused phosphorylation of ERK that was sustained for up to 16 h. COX-2 protein expression and PGE(2) synthesis were increased following exposure to combinations of stimuli that increased intracellular Ca(2+), and activated protein kinase C as well as ERK.	Calcimycin	55-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	178-183
17085321-5	2006	Sustained, maximum PGE(2) synthesis was observed when cells were stimulated such that ERK phosphorylation was concomitant with increased COX-2 protein expression.	Dinoprostone	19-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-142
17085321-6	2006	These results argue against redundancy in pathways for PGE(2) synthesis, and suggest that at various stages of inflammation different stimuli may influence ERK activation and COX-2 expression, so as to tightly regulate the kinetics and amount of PGE(2) produced by airway epithelial cells in response to lung inflammation.	Prostaglandins E	246-249	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	175-180
17085323-1	2006	Accumulating evidence suggests that COX-2-derived prostaglandin E(2) (PGE(2)) plays an important role in esophageal adenocarcinogenesis.	Dinoprostone	50-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-41
17085323-1	2006	Accumulating evidence suggests that COX-2-derived prostaglandin E(2) (PGE(2)) plays an important role in esophageal adenocarcinogenesis.	Dinoprostone	70-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-41
17085323-6	2006	Endogenous PGE(2) production was mainly due to COX-2, since this was significantly suppressed with COX-2 inhibitors (NS-398 and SC-58125), but not COX-1 inhibitors (SC-560).	Dinoprostone	11-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
17085323-6	2006	Endogenous PGE(2) production was mainly due to COX-2, since this was significantly suppressed with COX-2 inhibitors (NS-398 and SC-58125), but not COX-1 inhibitors (SC-560).	Dinoprostone	11-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-104
17085323-6	2006	Endogenous PGE(2) production was mainly due to COX-2, since this was significantly suppressed with COX-2 inhibitors (NS-398 and SC-58125), but not COX-1 inhibitors (SC-560).	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	117-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
17085323-6	2006	Endogenous PGE(2) production was mainly due to COX-2, since this was significantly suppressed with COX-2 inhibitors (NS-398 and SC-58125), but not COX-1 inhibitors (SC-560).	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	117-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-104
17085323-6	2006	Endogenous PGE(2) production was mainly due to COX-2, since this was significantly suppressed with COX-2 inhibitors (NS-398 and SC-58125), but not COX-1 inhibitors (SC-560).	1-((4-methylsulfonyl)phenyl)-3-trifluoromethyl-5-(4-fluorophenyl)pyrazole	128-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
17085323-6	2006	Endogenous PGE(2) production was mainly due to COX-2, since this was significantly suppressed with COX-2 inhibitors (NS-398 and SC-58125), but not COX-1 inhibitors (SC-560).	1-((4-methylsulfonyl)phenyl)-3-trifluoromethyl-5-(4-fluorophenyl)pyrazole	128-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-104
17162249-9	2006	The increased COX-2 in monocytes of older humans, which is mirrored in rats, may have downstream implications in atherosclerosis and cardiovascular risk as mononuclear prostanoids are implicated in atherosclerotic plaque stability.	Prostaglandins	168-179	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
16427185-3	2006	COX-2 was expressed in neoplastic mucinous epithelium of 30 cases (40%): 20 in PMCA (40%), 10 in DPAM (40%).	dpam	97-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
17088965-1	2006	Reactions of 3,4-dimethyl-3",4"-bis(diphenylphosphino)tetrathiafulvalene, o-P2, with [BF(4)](-) salts of Fe(ii), Co(ii), Ni(II), Pd(II), and Pt(II) yield complexes of general formula [M(o-P2)(2)][BF(4)](2).	3,4-dimethyl-3",4"-bis(diphenylphosphino)tetrathiafulvalene	13-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-110
17088965-1	2006	Reactions of 3,4-dimethyl-3",4"-bis(diphenylphosphino)tetrathiafulvalene, o-P2, with [BF(4)](-) salts of Fe(ii), Co(ii), Ni(II), Pd(II), and Pt(II) yield complexes of general formula [M(o-P2)(2)][BF(4)](2).	3,4-dimethyl-3",4"-bis(diphenylphosphino)tetrathiafulvalene	13-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-119
17088965-1	2006	Reactions of 3,4-dimethyl-3",4"-bis(diphenylphosphino)tetrathiafulvalene, o-P2, with [BF(4)](-) salts of Fe(ii), Co(ii), Ni(II), Pd(II), and Pt(II) yield complexes of general formula [M(o-P2)(2)][BF(4)](2).	3,4-dimethyl-3",4"-bis(diphenylphosphino)tetrathiafulvalene	13-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	124-126
17088965-1	2006	Reactions of 3,4-dimethyl-3",4"-bis(diphenylphosphino)tetrathiafulvalene, o-P2, with [BF(4)](-) salts of Fe(ii), Co(ii), Ni(II), Pd(II), and Pt(II) yield complexes of general formula [M(o-P2)(2)][BF(4)](2).	3,4-dimethyl-3",4"-bis(diphenylphosphino)tetrathiafulvalene	13-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-134
17088965-1	2006	Reactions of 3,4-dimethyl-3",4"-bis(diphenylphosphino)tetrathiafulvalene, o-P2, with [BF(4)](-) salts of Fe(ii), Co(ii), Ni(II), Pd(II), and Pt(II) yield complexes of general formula [M(o-P2)(2)][BF(4)](2).	3,4-dimethyl-3",4"-bis(diphenylphosphino)tetrathiafulvalene	13-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-134
17088965-1	2006	Reactions of 3,4-dimethyl-3",4"-bis(diphenylphosphino)tetrathiafulvalene, o-P2, with [BF(4)](-) salts of Fe(ii), Co(ii), Ni(II), Pd(II), and Pt(II) yield complexes of general formula [M(o-P2)(2)][BF(4)](2).	fluoroboric acid	86-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-110
17088965-1	2006	Reactions of 3,4-dimethyl-3",4"-bis(diphenylphosphino)tetrathiafulvalene, o-P2, with [BF(4)](-) salts of Fe(ii), Co(ii), Ni(II), Pd(II), and Pt(II) yield complexes of general formula [M(o-P2)(2)][BF(4)](2).	fluoroboric acid	86-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-119
17088965-1	2006	Reactions of 3,4-dimethyl-3",4"-bis(diphenylphosphino)tetrathiafulvalene, o-P2, with [BF(4)](-) salts of Fe(ii), Co(ii), Ni(II), Pd(II), and Pt(II) yield complexes of general formula [M(o-P2)(2)][BF(4)](2).	fluoroboric acid	86-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	124-126
17088965-1	2006	Reactions of 3,4-dimethyl-3",4"-bis(diphenylphosphino)tetrathiafulvalene, o-P2, with [BF(4)](-) salts of Fe(ii), Co(ii), Ni(II), Pd(II), and Pt(II) yield complexes of general formula [M(o-P2)(2)][BF(4)](2).	fluoroboric acid	86-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-134
17088965-1	2006	Reactions of 3,4-dimethyl-3",4"-bis(diphenylphosphino)tetrathiafulvalene, o-P2, with [BF(4)](-) salts of Fe(ii), Co(ii), Ni(II), Pd(II), and Pt(II) yield complexes of general formula [M(o-P2)(2)][BF(4)](2).	fluoroboric acid	86-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-134
17112248-1	2006	Two cyanide-bridged WV-M [M = Mn(II) (1), Co(II) (2)] bimetallic clusters were prepared by self-assembling a new molecular precursor [W(CN)6(bpy)]- and the corresponding metal complexes.	Cyanides	4-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-48
17723766-2	2006	The fluorescence quenching of 1 was attributed to the formation of an inclusion complex between multi-substituted phenol unit and Co(II) by 1:1 complex ratio (K=2.5 x 10(5)), which has been utilized as the basis of the fabrication of the Co(II)-sensitive fluorescent chemosensor.	Phenol	114-120	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	130-136
17723766-2	2006	The fluorescence quenching of 1 was attributed to the formation of an inclusion complex between multi-substituted phenol unit and Co(II) by 1:1 complex ratio (K=2.5 x 10(5)), which has been utilized as the basis of the fabrication of the Co(II)-sensitive fluorescent chemosensor.	Phenol	114-120	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	130-135
17723766-4	2006	The sensor can be applied to the quantification of Co(II) with a linear range covering from 1.0 x 10(-7) to 5.0 x 10(-5) M and a detection limit of 5 x 10(-8) M. The experiment results show that the response behavior of 1 to Co(II) is pH-independent in medium condition (pH 4.5-9.5) and show excellent selectivity for Co(II) over transition metal cations except Cu(II).	Metals	341-346	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-57
17723766-4	2006	The sensor can be applied to the quantification of Co(II) with a linear range covering from 1.0 x 10(-7) to 5.0 x 10(-5) M and a detection limit of 5 x 10(-8) M. The experiment results show that the response behavior of 1 to Co(II) is pH-independent in medium condition (pH 4.5-9.5) and show excellent selectivity for Co(II) over transition metal cations except Cu(II).	Metals	341-346	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	225-231
17723766-4	2006	The sensor can be applied to the quantification of Co(II) with a linear range covering from 1.0 x 10(-7) to 5.0 x 10(-5) M and a detection limit of 5 x 10(-8) M. The experiment results show that the response behavior of 1 to Co(II) is pH-independent in medium condition (pH 4.5-9.5) and show excellent selectivity for Co(II) over transition metal cations except Cu(II).	Metals	341-346	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	225-231
17723766-4	2006	The sensor can be applied to the quantification of Co(II) with a linear range covering from 1.0 x 10(-7) to 5.0 x 10(-5) M and a detection limit of 5 x 10(-8) M. The experiment results show that the response behavior of 1 to Co(II) is pH-independent in medium condition (pH 4.5-9.5) and show excellent selectivity for Co(II) over transition metal cations except Cu(II).	cu(ii)	362-368	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-57
17723766-4	2006	The sensor can be applied to the quantification of Co(II) with a linear range covering from 1.0 x 10(-7) to 5.0 x 10(-5) M and a detection limit of 5 x 10(-8) M. The experiment results show that the response behavior of 1 to Co(II) is pH-independent in medium condition (pH 4.5-9.5) and show excellent selectivity for Co(II) over transition metal cations except Cu(II).	cu(ii)	362-368	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	225-231
17723766-4	2006	The sensor can be applied to the quantification of Co(II) with a linear range covering from 1.0 x 10(-7) to 5.0 x 10(-5) M and a detection limit of 5 x 10(-8) M. The experiment results show that the response behavior of 1 to Co(II) is pH-independent in medium condition (pH 4.5-9.5) and show excellent selectivity for Co(II) over transition metal cations except Cu(II).	cu(ii)	362-368	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	225-231
17723766-5	2006	The chemosensor has been used for determination of Co(II) in water samples.	Water	61-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-57
17723778-0	2006	Application of lead film electrode for simultaneous adsorptive stripping voltammetric determination of Ni(II) and Co(II) as their nioxime complexes.	(1Z,2Z)-Cyclohexane-1,2-dione dioxime	130-137	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-120
17723778-1	2006	An adsorptive stripping voltammetric (AdSV) procedure for simultaneous determination of Ni(II) and Co(II) in the presence of nioxime as a complexing agent at an in situ plated lead film electrode was described.	(1Z,2Z)-Cyclohexane-1,2-dione dioxime	125-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-105
17723778-2	2006	The Co(II) signal was enhanced by exploitation of the catalytic process in the presence of nitrite.	Nitrites	91-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
17723778-4	2006	Calibration graphs for an accumulation time of 120 s are linear from 1 x 10(-9) to 1 x 10(-7) mol L(-1) and from 1 x 10(-10) to 5 x 10(-9) mol L(-1) for Ni(II) and Co(II), respectively.	Nickel(2+)	153-159	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	164-170
17723778-5	2006	The proposed procedure was applied for Ni(II) and Co(II) determination in water certified reference materials.	Water	74-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-56
16973179-11	2006	In conclusion, our high-throughput screening models in combination with quantitative assessment of changes in gene expression profiles identified the avarol derivative 13, a benzylamine derivative of avarol at the 4" position of benzoquinone ring, as an interesting anti-psoriatic drug candidate that inhibits keratinocyte cell growth and TNFalpha and COX-2 expression.	avarol	150-156	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	352-357
16973179-11	2006	In conclusion, our high-throughput screening models in combination with quantitative assessment of changes in gene expression profiles identified the avarol derivative 13, a benzylamine derivative of avarol at the 4" position of benzoquinone ring, as an interesting anti-psoriatic drug candidate that inhibits keratinocyte cell growth and TNFalpha and COX-2 expression.	benzylamine	174-185	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	352-357
16973179-11	2006	In conclusion, our high-throughput screening models in combination with quantitative assessment of changes in gene expression profiles identified the avarol derivative 13, a benzylamine derivative of avarol at the 4" position of benzoquinone ring, as an interesting anti-psoriatic drug candidate that inhibits keratinocyte cell growth and TNFalpha and COX-2 expression.	avarol	200-206	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	352-357
16973179-11	2006	In conclusion, our high-throughput screening models in combination with quantitative assessment of changes in gene expression profiles identified the avarol derivative 13, a benzylamine derivative of avarol at the 4" position of benzoquinone ring, as an interesting anti-psoriatic drug candidate that inhibits keratinocyte cell growth and TNFalpha and COX-2 expression.	quinone	229-241	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	352-357
17111043-1	2006	OBJECTIVES: The Alzheimer"s Disease Anti-inflammatory Prevention Trial (ADAPT) was designed to evaluate the conventional NSAID naproxen sodium and the selective COX-2 inhibitor celecoxib for primary prevention of Alzheimer"s dementia (AD).	Celecoxib	177-186	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	161-166
17107625-12	2006	CONCLUSION: The increases of COX-1, COX-2, mPGES-1 and EP1-2 in epithelial ovarian cancer, supports the hypothesis that PGE2-synthesis and signalling are of importance for malignant transformation and progression.	Dinoprostone	120-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-41
20496448-0	2006	Drug Class Review: Cyclo-oxygenase (COX)-2 Inhibitors and Non-steroidal Anti-inflammatory Drugs (NSAIDs): Final Report Update 3 Non-steroidal anti-inflammatory drugs (NSAIDs) reduce pain and inflammation by blocking cyclo-oxygenases (COX), enzymes that are needed to produce prostaglandins.	Prostaglandins	275-289	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-42
17047739-0	2006	Dinuclear Co(III)/Co(III) and Co(II)/Co(III) mixed-valent complexes: synthetic control of the cobalt oxidation level.	Cobalt	94-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-36
17073484-2	2006	Clays used were sodium montmorillonite (denoted as mont) and synthetic smectite containing Co(II) ions in the octahedral sites (denoted as Co).	Smectite	71-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-97
17073484-8	2006	In contrast, the same complexes in the Ru-Co film were electrochemically active with the simultaneous appearance of the redox peaks due to the Co(II)/Co(III) (or Co(II)/Co(IV)) couple.	co(iv)	169-175	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	162-168
17073484-9	2006	The results implied that electron transfer through cobalt clay layers was possible via mediation by Co(II) ions in a clay sheet.	Cobalt	51-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-106
16950767-3	2006	We report that COX-2 expression is up-regulated in phorbol ester (phorbol myristate acetate, PMA)-differentiated human U937 macrophage-like cells stimulated with lipopolysaccharide (LPS), whereas COX-1 is not up-regulated.	Phorbol Esters	51-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-20
16950767-3	2006	We report that COX-2 expression is up-regulated in phorbol ester (phorbol myristate acetate, PMA)-differentiated human U937 macrophage-like cells stimulated with lipopolysaccharide (LPS), whereas COX-1 is not up-regulated.	Tetradecanoylphorbol Acetate	66-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-20
16950767-3	2006	We report that COX-2 expression is up-regulated in phorbol ester (phorbol myristate acetate, PMA)-differentiated human U937 macrophage-like cells stimulated with lipopolysaccharide (LPS), whereas COX-1 is not up-regulated.	Tetradecanoylphorbol Acetate	93-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-20
16950767-4	2006	We show that the LPS-induced up-regulation of COX-2 depends on the activity of the Mg(+2)-dependent phosphatidic acid phosphohydrolase 1 (PAP-1).	mg(+2)	83-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
16950767-5	2006	Inhibition of PAP-1 by bromoenol lactone, propranolol, or ethanol resulted in a decrease in LPS-induced COX-2 mRNA transcript production, COX-2 protein expression, and prostaglandin E(2) release from U937 macrophages.	6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one	23-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
16950767-5	2006	Inhibition of PAP-1 by bromoenol lactone, propranolol, or ethanol resulted in a decrease in LPS-induced COX-2 mRNA transcript production, COX-2 protein expression, and prostaglandin E(2) release from U937 macrophages.	6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one	23-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	138-143
16950767-5	2006	Inhibition of PAP-1 by bromoenol lactone, propranolol, or ethanol resulted in a decrease in LPS-induced COX-2 mRNA transcript production, COX-2 protein expression, and prostaglandin E(2) release from U937 macrophages.	Propranolol	42-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
16950767-5	2006	Inhibition of PAP-1 by bromoenol lactone, propranolol, or ethanol resulted in a decrease in LPS-induced COX-2 mRNA transcript production, COX-2 protein expression, and prostaglandin E(2) release from U937 macrophages.	Propranolol	42-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	138-143
16950767-5	2006	Inhibition of PAP-1 by bromoenol lactone, propranolol, or ethanol resulted in a decrease in LPS-induced COX-2 mRNA transcript production, COX-2 protein expression, and prostaglandin E(2) release from U937 macrophages.	Ethanol	58-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
16950767-5	2006	Inhibition of PAP-1 by bromoenol lactone, propranolol, or ethanol resulted in a decrease in LPS-induced COX-2 mRNA transcript production, COX-2 protein expression, and prostaglandin E(2) release from U937 macrophages.	Ethanol	58-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	138-143
16950767-10	2006	Finally, DAG add-back experiments demonstrate that LPS-induced COX-2 expression is enhanced by the addition of exogenous DAG.	Diglycerides	9-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-68
17080978-0	2006	Review: selective COX-2 inhibitors increase vascular events more than placebo and naproxen, but not more than other NSAIDs.	Naproxen	82-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-23
16940060-8	2006	The effects of ddI, but not those of AZT, on mtDNA and COII mRNA were further enhanced in the presence of TFV, a finding consistent with the inhibition of ddI clearance by TFV.	Didanosine	15-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-59
16940060-8	2006	The effects of ddI, but not those of AZT, on mtDNA and COII mRNA were further enhanced in the presence of TFV, a finding consistent with the inhibition of ddI clearance by TFV.	Tenofovir	106-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-59
16940060-9	2006	The addition of TFV to ddI or AZT appeared to slightly increase the COII mRNA/mtDNA ratio relative to that in cells treated with ddI or AZT alone.	Tenofovir	16-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-72
16940060-9	2006	The addition of TFV to ddI or AZT appeared to slightly increase the COII mRNA/mtDNA ratio relative to that in cells treated with ddI or AZT alone.	Didanosine	23-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-72
16940060-9	2006	The addition of TFV to ddI or AZT appeared to slightly increase the COII mRNA/mtDNA ratio relative to that in cells treated with ddI or AZT alone.	Zidovudine	30-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-72
16963022-9	2006	Consistent with these findings, overexpression of COX-2 significantly reduced FGF-2-induced cell proliferation whereas a COX-2 specific inhibitor NS398 reversed the effect of TGF-beta2 on FGF-2-induced cell proliferation.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	146-151	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-126
17002607-8	2006	After 50 mg or 100 mg HE2000, but not after placebo, there were significant sustained decreases in IL-1beta, TNF-alpha, IL-6 and Cox-2 transcripts (p &lt; 0.05).	16alpha-bromo-3beta-hydroxy-5alpha-androstan-17-one	22-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-134
16963022-10	2006	The COX-2 product prostaglandin E2 (PGE-2) blocks FGF-2-induced cell proliferation.	Dinoprostone	18-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
16963022-10	2006	The COX-2 product prostaglandin E2 (PGE-2) blocks FGF-2-induced cell proliferation.	Dinoprostone	36-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
17016619-9	2006	The anti-IgE antibody also significantly suppressed the activities of MPO and chymase as well as the expression of TNF-alpha and COX-2 in the DSS-treated colon tissue.	Dextran Sulfate	142-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-134
17062883-12	2006	COX-2 expression showed a statistically significant positive correlation with TES (r = 0.634, P = 0.001), and a negative correlation with the disease duration (r = -0.621, P = 0.002).	TES	78-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
17115981-3	2006	The Cox2 inhibitor, rofecoxib, has been reported effective in preventing perimenstrual migraine and in preventing recurrence of migraine.	rofecoxib	20-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-8
16930602-1	2006	OBJECTIVE: To investigate the activities of the 2 isoforms of prostaglandin synthetic enzyme cyclo-oxygenase (COX), COX-1 and COX-2, in the placental tissue of women with pre-eclampsia and healthy pregnant women.	Prostaglandins	62-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-131
17016639-2	2006	KB/COX-2 clones showed a similar growth rate in vitro compared to KB/neo clones, but demonstrated significantly increased PGE2 production, cell migration and invasion.	Dinoprostone	122-126	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	3-8
16952320-4	2006	Aspirin is an inhibitor of COX-2 and has been implicated, with other non-steroidal anti-inflammatory drugs (NSAIDS) in prevention and treatment of breast cancer.	Aspirin	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-32
17136297-9	2006	Selective COX 2 inhibitors can be prescribed in some cases of allergy to aspirin, but they must be used with care.	Aspirin	73-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
17121918-1	2006	Cyclooxygenase (COX)-2 and 5-lipoxygenase (5-LOX) are key enzymes involved in arachidonic acid metabolism.	Arachidonic Acid	78-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-22
16503413-2	2006	The UV-vis absorption spectra of SBH and its Co(II) complexes in various media were studied by using the deconvolution method.	salicylaldehyde benzoyl hydrazone	33-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-51
16679052-6	2006	The electrochemical behaviour of the cobalt(II) complexes, the Co(III)/Co(II) couple are observed.	Cobalt(2+)	37-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-68
17054329-3	2006	The result is that sequential switching from high-spin Co(II) to low-spin Co(III) of one center, followed by the onset of switching of the other center at lower temperature, is observed in a solid amorphous thin film by IR absorption spectroscopy.	co(iii)	74-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-61
17054353-8	2006	Complexes 3 and 4 show significant metamagnetic behavior, where the cyanides mediate the intrachain ferromagnetic coupling between Fe(III) and Co(II) or Ni(II) ions and the interchain pi-pi stacking interactions lead to antiferromagnetic couplings.	Cyanides	68-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	143-149
17029361-1	2006	The coordination of the cations Cu(II), Co(II), Rh(III), Ir(III), Ni(II), Pd(II), Pt(II), and Zn(II) to the copper-binding octapeptide region in the human prion protein has been compared through structural optimization.	Copper	108-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-46
17029361-3	2006	The computational results show that, among these cations, the coordinations of Co(II) and Rh(III) are the most similar to that of Cu(II).	cu(ii)	130-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-85
17044934-3	2006	At the molecular level, resveratrol has been reported to inhibit cyclooxygenase (COX) expression and/or activity; in endometrial cancer cells, COX-2 is overexpressed and confers cellular resistance to apoptosis.	Resveratrol	24-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	143-148
17044934-4	2006	The aim of the present study was to determine if resveratrol could exert anti-proliferative and pro-apoptotic activity over uterine cancer cells upon inhibition of COX-2 expression and/or activity.	Resveratrol	49-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	164-169
17044934-9	2006	Endogenous COX-2 protein levels were decreased, concomitant with a decrease in production of COX metabolites PGE2 and PGF2alpha, in each uterine cancer cell line expressing detectable levels of COX-1 and/or COX-2 in presence of resveratrol.	Dinoprostone	109-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-16
17044934-9	2006	Endogenous COX-2 protein levels were decreased, concomitant with a decrease in production of COX metabolites PGE2 and PGF2alpha, in each uterine cancer cell line expressing detectable levels of COX-1 and/or COX-2 in presence of resveratrol.	Dinoprost	118-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-16
17044934-9	2006	Endogenous COX-2 protein levels were decreased, concomitant with a decrease in production of COX metabolites PGE2 and PGF2alpha, in each uterine cancer cell line expressing detectable levels of COX-1 and/or COX-2 in presence of resveratrol.	Resveratrol	228-239	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-16
17199977-4	2006	RESULTS: (1) The expression of COX-2 protein in the glandular cells of the CSG, CAG, and IM + DYS groups were 42.7%, 45.8%, and 61.1% respectively, all significantly higher than that of the control group (20%, P &lt; 0.01 or 0.05).	dys	94-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-36
16798002-1	2006	A group of (E)-1,3-diphenylprop-2-en-1-one derivatives (chalcones) possessing a MeSO(2)NH, or N(3), COX-2 pharmacophore at the para-position of the C-1 phenyl ring were synthesized using a facile stereoselective Claisen-Schmidt condensation reaction.	Chalcone	11-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-105
16798002-1	2006	A group of (E)-1,3-diphenylprop-2-en-1-one derivatives (chalcones) possessing a MeSO(2)NH, or N(3), COX-2 pharmacophore at the para-position of the C-1 phenyl ring were synthesized using a facile stereoselective Claisen-Schmidt condensation reaction.	Chalcones	56-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-105
16798002-1	2006	A group of (E)-1,3-diphenylprop-2-en-1-one derivatives (chalcones) possessing a MeSO(2)NH, or N(3), COX-2 pharmacophore at the para-position of the C-1 phenyl ring were synthesized using a facile stereoselective Claisen-Schmidt condensation reaction.	meso(2)nh	80-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-105
16798002-4	2006	The corresponding 1,3-diphenylprop-2-en-1-one analogue possessing a C-1 para-N(3) COX-2 pharmacophore, (E)-1-(4-azidophenyl)-3-(4-methylphenyl)prop-2-en-1-one (7f), exhibited potent and selective COX-2 inhibition (COX-1 IC(50)=22.2 microM; COX-2 IC(50)=0.3 microM; SI=60).	Chalcone	18-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
16798002-4	2006	The corresponding 1,3-diphenylprop-2-en-1-one analogue possessing a C-1 para-N(3) COX-2 pharmacophore, (E)-1-(4-azidophenyl)-3-(4-methylphenyl)prop-2-en-1-one (7f), exhibited potent and selective COX-2 inhibition (COX-1 IC(50)=22.2 microM; COX-2 IC(50)=0.3 microM; SI=60).	Chalcone	18-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	196-201
16798002-4	2006	The corresponding 1,3-diphenylprop-2-en-1-one analogue possessing a C-1 para-N(3) COX-2 pharmacophore, (E)-1-(4-azidophenyl)-3-(4-methylphenyl)prop-2-en-1-one (7f), exhibited potent and selective COX-2 inhibition (COX-1 IC(50)=22.2 microM; COX-2 IC(50)=0.3 microM; SI=60).	Chalcone	18-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	196-201
16798002-4	2006	The corresponding 1,3-diphenylprop-2-en-1-one analogue possessing a C-1 para-N(3) COX-2 pharmacophore, (E)-1-(4-azidophenyl)-3-(4-methylphenyl)prop-2-en-1-one (7f), exhibited potent and selective COX-2 inhibition (COX-1 IC(50)=22.2 microM; COX-2 IC(50)=0.3 microM; SI=60).	(e)-1-(4-azidophenyl)-3-(4-methylphenyl)prop-2-en-1-one	103-158	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
16798002-4	2006	The corresponding 1,3-diphenylprop-2-en-1-one analogue possessing a C-1 para-N(3) COX-2 pharmacophore, (E)-1-(4-azidophenyl)-3-(4-methylphenyl)prop-2-en-1-one (7f), exhibited potent and selective COX-2 inhibition (COX-1 IC(50)=22.2 microM; COX-2 IC(50)=0.3 microM; SI=60).	(e)-1-(4-azidophenyl)-3-(4-methylphenyl)prop-2-en-1-one	103-158	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	196-201
16798002-4	2006	The corresponding 1,3-diphenylprop-2-en-1-one analogue possessing a C-1 para-N(3) COX-2 pharmacophore, (E)-1-(4-azidophenyl)-3-(4-methylphenyl)prop-2-en-1-one (7f), exhibited potent and selective COX-2 inhibition (COX-1 IC(50)=22.2 microM; COX-2 IC(50)=0.3 microM; SI=60).	(e)-1-(4-azidophenyl)-3-(4-methylphenyl)prop-2-en-1-one	103-158	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	196-201
16798002-5	2006	A molecular modeling study where 7b and 7f were docked in the binding site of COX-2 showed that the p-MeSO(2)NH and N(3) substituents on the C-1 phenyl ring are oriented in the vicinity of the COX-2 secondary pocket (His90, Arg513, Phe518, and Val523).	p-meso(2)nh	100-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-83
16798002-5	2006	A molecular modeling study where 7b and 7f were docked in the binding site of COX-2 showed that the p-MeSO(2)NH and N(3) substituents on the C-1 phenyl ring are oriented in the vicinity of the COX-2 secondary pocket (His90, Arg513, Phe518, and Val523).	p-meso(2)nh	100-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	193-198
16798002-6	2006	The structure-activity data acquired indicate that the propenone moiety constitutes a suitable scaffold to design new acyclic 1,3-diphenylprop-2-en-1-ones with selective COX-1 or COX-2 inhibitory activity.	propenone	55-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	179-184
16798002-6	2006	The structure-activity data acquired indicate that the propenone moiety constitutes a suitable scaffold to design new acyclic 1,3-diphenylprop-2-en-1-ones with selective COX-1 or COX-2 inhibitory activity.	Chalcone	126-154	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	179-184
17017774-0	2006	Probing the reaction mechanism of the D-ala-D-ala dipeptidase, VanX, by using stopped-flow kinetic and rapid-freeze quench EPR studies on the Co(II)-substituted enzyme.	vanx	63-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	142-148
17017774-1	2006	In an effort to probe the reaction mechanism of VanX, the d-ala-d-ala dipeptidase required for high-level vancomycin resistance in bacteria, stopped-flow kinetic and rapid-freeze quench EPR studies were conducted on the Co(II)-substituted enzyme when reacted with d-ala-d-ala.	vanx	48-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	220-226
17017774-1	2006	In an effort to probe the reaction mechanism of VanX, the d-ala-d-ala dipeptidase required for high-level vancomycin resistance in bacteria, stopped-flow kinetic and rapid-freeze quench EPR studies were conducted on the Co(II)-substituted enzyme when reacted with d-ala-d-ala.	alanylalanine	58-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	220-226
17017774-2	2006	The intensity of the Co(II) ligand field band at 550 nm decreased (epsilon550 = 140 to 18 M-1 cm-1) when VanX was reacted with substrate, suggesting that the coordination number of the metal increases from 5 to 6 upon substrate binding.	vanx	105-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-27
17017774-2	2006	The intensity of the Co(II) ligand field band at 550 nm decreased (epsilon550 = 140 to 18 M-1 cm-1) when VanX was reacted with substrate, suggesting that the coordination number of the metal increases from 5 to 6 upon substrate binding.	Metals	185-190	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-27
17018645-2	2006	Cyclooxygenase (COX)-2 is responsible for the overproduction of prostaglandins (PG) at inflammatory sites, and its expression is increased in atheroma.	Prostaglandins	64-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-22
17018645-2	2006	Cyclooxygenase (COX)-2 is responsible for the overproduction of prostaglandins (PG) at inflammatory sites, and its expression is increased in atheroma.	Prostaglandins	80-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-22
17018645-3	2006	We studied the effects of DHA on COX-2 expression and activity in human saphenous vein endothelial cells challenged with proinflammatory stimuli.	Docosahexaenoic Acids	26-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-38
17018645-4	2006	A&gt;or=24-h exposure to DHA reduced COX-2 expression and activity induced by IL-1, without affecting COX-1 expression.	Docosahexaenoic Acids	25-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-42
17018645-5	2006	DHA effect depended on the NF-kappaB-binding site in the COX-2 promoter.	Docosahexaenoic Acids	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-62
17003500-5	2006	In the presence of a cyclooxygenase (COX)-2 inhibitor, serotonin-mediated contraction was partially reduced in arteries treated with healthy microparticles but was abolished after treatment with preeclamptic microparticles.	Serotonin	55-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-43
16939524-1	2006	AIM: To examine the risk of angio-oedema among users of the newer cyclooxygenase (COX)-2 selective inhibitors celecoxib and rofecoxib and other non-aspirin nonsteroidal anti-inflammatory drugs (NSAIDs) in a population-based case-control study.	Celecoxib	110-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-88
16939524-1	2006	AIM: To examine the risk of angio-oedema among users of the newer cyclooxygenase (COX)-2 selective inhibitors celecoxib and rofecoxib and other non-aspirin nonsteroidal anti-inflammatory drugs (NSAIDs) in a population-based case-control study.	rofecoxib	124-133	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-88
17018629-8	2006	Treatment of Caco-2 cells with the most abundant and toxic lipid aldehyde 4-hydroxy-trans-2-nonenal (HNE) or its glutathione-conjugate [glutathionyl-HNE (GS-HNE)] or AR-catalyzed product of GS-HNE, glutathionyl-1,4-dihydroxynonane (GS-DHN), resulted in increased COX-2 expression and PGE(2) production.	4-hydroxy-trans-2-nonenal	74-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	263-268
16968406-5	2006	Pretreatment with low-dose nicotine caused inhibition of TNF-alpha, PGE(2), MIP-1alpha and MIP-1alpha production, and mRNA expression of TNF-alpha, MIP-1alpha and MIP-1alpha and COX-2 in lipopolysaccharide (LPS)-activated monocytes.	Nicotine	27-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	178-183
16964399-2	2006	Two human breast cancer cell lines (HTB26, MCF-7) were treated with catechin (Cox-1 inhibitor) or NS398 (Cox-2 inhibitor) at 100 microM as both single and combined treatments.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	98-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-110
16741257-0	2006	Polyamine-mediated reduction in human airway epithelial migration in response to wounding is PGE2 dependent through decreases in COX-2 and cPLA2 protein levels.	Polyamines	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-134
16741257-0	2006	Polyamine-mediated reduction in human airway epithelial migration in response to wounding is PGE2 dependent through decreases in COX-2 and cPLA2 protein levels.	Dinoprostone	93-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-134
16998585-1	2006	Tight regulation of COX-2 expression is a key feature controlling eicosanoid production in atherosclerosis and other inflammatory syndromes.	Eicosanoids	66-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-25
16844225-6	2006	It is shown that Zn(II) and its substitutes Cd(II)/Co(II) bind to humanin via a thiolate bond from the side chain of the single cysteine at position 8.	Zinc	17-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-57
16844225-6	2006	It is shown that Zn(II) and its substitutes Cd(II)/Co(II) bind to humanin via a thiolate bond from the side chain of the single cysteine at position 8.	cd(ii)	44-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-57
16844225-6	2006	It is shown that Zn(II) and its substitutes Cd(II)/Co(II) bind to humanin via a thiolate bond from the side chain of the single cysteine at position 8.	thiolate	80-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-57
16844225-6	2006	It is shown that Zn(II) and its substitutes Cd(II)/Co(II) bind to humanin via a thiolate bond from the side chain of the single cysteine at position 8.	Cysteine	128-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-57
16713604-5	2006	The purpose of this study was to evaluate the effectiveness of inhibiting COX-2 with FK3311 for the minimization of ischemia-reperfusion injury and for the improvement of donor heart function following transplantation in a canine model.	FK 3311	85-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
16957004-5	2006	Experimental studies demonstrate that prostaglandin E(2) (PGE(2)), mainly derived from the COX-2 reaction, is an important mediator, acting as a retrograde messenger via a presynaptic PGE(2) subtype 2 receptor (EP(2)) in modulation of synaptic events.	Dinoprostone	38-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-96
16957004-5	2006	Experimental studies demonstrate that prostaglandin E(2) (PGE(2)), mainly derived from the COX-2 reaction, is an important mediator, acting as a retrograde messenger via a presynaptic PGE(2) subtype 2 receptor (EP(2)) in modulation of synaptic events.	Prostaglandins E	58-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-96
16957004-5	2006	Experimental studies demonstrate that prostaglandin E(2) (PGE(2)), mainly derived from the COX-2 reaction, is an important mediator, acting as a retrograde messenger via a presynaptic PGE(2) subtype 2 receptor (EP(2)) in modulation of synaptic events.	Prostaglandins E	184-187	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-96
16957004-6	2006	Novel prostaglandins (prostaglandin glycerol esters and prostaglandin ethanolamides) are COX-2 oxidative metabolites of endogenous cannabinoids (2-arachidonyl glycerol and arachidonyl ethanolamide).	Prostaglandins	6-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-94
16957004-6	2006	Novel prostaglandins (prostaglandin glycerol esters and prostaglandin ethanolamides) are COX-2 oxidative metabolites of endogenous cannabinoids (2-arachidonyl glycerol and arachidonyl ethanolamide).	prostaglandin glycerol esters	22-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-94
16957004-6	2006	Novel prostaglandins (prostaglandin glycerol esters and prostaglandin ethanolamides) are COX-2 oxidative metabolites of endogenous cannabinoids (2-arachidonyl glycerol and arachidonyl ethanolamide).	prostaglandin ethanolamides	56-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-94
16957004-6	2006	Novel prostaglandins (prostaglandin glycerol esters and prostaglandin ethanolamides) are COX-2 oxidative metabolites of endogenous cannabinoids (2-arachidonyl glycerol and arachidonyl ethanolamide).	Cannabinoids	131-143	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-94
16957004-6	2006	Novel prostaglandins (prostaglandin glycerol esters and prostaglandin ethanolamides) are COX-2 oxidative metabolites of endogenous cannabinoids (2-arachidonyl glycerol and arachidonyl ethanolamide).	glyceryl 2-arachidonate	145-167	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-94
16957004-6	2006	Novel prostaglandins (prostaglandin glycerol esters and prostaglandin ethanolamides) are COX-2 oxidative metabolites of endogenous cannabinoids (2-arachidonyl glycerol and arachidonyl ethanolamide).	anandamide	172-196	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-94
16957004-8	2006	This means that COX- 2 plays a central role in metabolisms of AA and endocannabinoids (eCBs) and productions of AA- and eCB- derived prostaglandins.	Endocannabinoids	87-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-22
16957004-8	2006	This means that COX- 2 plays a central role in metabolisms of AA and endocannabinoids (eCBs) and productions of AA- and eCB- derived prostaglandins.	Prostaglandins	133-147	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-22
16957004-9	2006	Thus, in the present review article, the authors will mainly discuss COX-2 regulation of prostaglandin signaling in modulation of hippocampal synaptic transmission and plasticity.	Prostaglandins	89-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-74
17071117-2	2006	With the demonstration of two major COX isoforms, COX-1 and COX-2, involved in the production of prostanoids, but with different distribution and regulation, selective COX-2 inhibitors have been developed.	Prostaglandins	97-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-65
17071117-2	2006	With the demonstration of two major COX isoforms, COX-1 and COX-2, involved in the production of prostanoids, but with different distribution and regulation, selective COX-2 inhibitors have been developed.	Prostaglandins	97-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	168-173
17003913-4	2006	The cardiovascular hazard is plausibly explained by the depression of COX-2 dependent prostanoids formed in vasculature and kidney; vascular prostacyclin (PGI2) constrains the effect of prothrombotic and atherogenic stimuli, and renal medullary prostacyclin and prostaglandin (PG) E(2) formed by COX-2 contribute to arterial pressure homeostasis.	Prostaglandins	86-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-75
17003913-4	2006	The cardiovascular hazard is plausibly explained by the depression of COX-2 dependent prostanoids formed in vasculature and kidney; vascular prostacyclin (PGI2) constrains the effect of prothrombotic and atherogenic stimuli, and renal medullary prostacyclin and prostaglandin (PG) E(2) formed by COX-2 contribute to arterial pressure homeostasis.	Epoprostenol	141-153	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	296-301
17003913-4	2006	The cardiovascular hazard is plausibly explained by the depression of COX-2 dependent prostanoids formed in vasculature and kidney; vascular prostacyclin (PGI2) constrains the effect of prothrombotic and atherogenic stimuli, and renal medullary prostacyclin and prostaglandin (PG) E(2) formed by COX-2 contribute to arterial pressure homeostasis.	Epoprostenol	155-159	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	296-301
17003913-4	2006	The cardiovascular hazard is plausibly explained by the depression of COX-2 dependent prostanoids formed in vasculature and kidney; vascular prostacyclin (PGI2) constrains the effect of prothrombotic and atherogenic stimuli, and renal medullary prostacyclin and prostaglandin (PG) E(2) formed by COX-2 contribute to arterial pressure homeostasis.	Epoprostenol	245-257	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-75
17003913-4	2006	The cardiovascular hazard is plausibly explained by the depression of COX-2 dependent prostanoids formed in vasculature and kidney; vascular prostacyclin (PGI2) constrains the effect of prothrombotic and atherogenic stimuli, and renal medullary prostacyclin and prostaglandin (PG) E(2) formed by COX-2 contribute to arterial pressure homeostasis.	Dinoprostone	262-285	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-75
16970972-1	2006	The efficiency of Co(II)-, Mn(II)-, and Ti(IV)-doped carbon aerogels for the transformation of ozone into (*)OH radicals was investigated.	Carbon	53-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-25
16970972-1	2006	The efficiency of Co(II)-, Mn(II)-, and Ti(IV)-doped carbon aerogels for the transformation of ozone into (*)OH radicals was investigated.	Ozone	95-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-25
16970972-1	2006	The efficiency of Co(II)-, Mn(II)-, and Ti(IV)-doped carbon aerogels for the transformation of ozone into (*)OH radicals was investigated.	(*)oh radicals	106-120	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-25
16621014-0	2006	Microwave-assisted antigen retrieval and incubation with cox-2 antibody of archival paraffin-embedded human oligodendroglioma and astrocytomas.	Paraffin	84-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-62
16933350-0	2006	Assembling magnetic nanowires into networks: a layered CoII carboxylate coordination polymer exhibiting single-chain-magnet behavior.	Polymers	85-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-59
16781106-0	2006	Rationalization of physicochemical characters of 1,5-diarylpyrazole analogs as dual (COX-2/LOX-5) inhibitors: a QSAR approach.	1,5-diarylpyrazole	49-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-90
16958516-3	2006	The peroxy diols and their acetonide derivatives were also ring-opened with Co(II) salen complexes to give novel hydroxy ketones in 77-100% yield, including the natural sugar psicose.	peroxy diols	4-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-82
16958516-3	2006	The peroxy diols and their acetonide derivatives were also ring-opened with Co(II) salen complexes to give novel hydroxy ketones in 77-100% yield, including the natural sugar psicose.	acetonide	27-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-82
16954617-1	2006	In the title compound, [CoCl2(C11H15N3O2)], the CoII ion is five-coordinated in a strongly distorted square-pyramidal arrangement, with one of the two Cl atoms located in the apical position, and the other Cl atom and the three N-donor atoms of the tridentate methyloxime ligand located in the basal plane.	cobaltous chloride	24-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-52
16954617-1	2006	In the title compound, [CoCl2(C11H15N3O2)], the CoII ion is five-coordinated in a strongly distorted square-pyramidal arrangement, with one of the two Cl atoms located in the apical position, and the other Cl atom and the three N-donor atoms of the tridentate methyloxime ligand located in the basal plane.	c11h15n3o2	30-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-52
16954617-1	2006	In the title compound, [CoCl2(C11H15N3O2)], the CoII ion is five-coordinated in a strongly distorted square-pyramidal arrangement, with one of the two Cl atoms located in the apical position, and the other Cl atom and the three N-donor atoms of the tridentate methyloxime ligand located in the basal plane.	Nitrogen	36-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-52
16954617-1	2006	In the title compound, [CoCl2(C11H15N3O2)], the CoII ion is five-coordinated in a strongly distorted square-pyramidal arrangement, with one of the two Cl atoms located in the apical position, and the other Cl atom and the three N-donor atoms of the tridentate methyloxime ligand located in the basal plane.	methyloxime	260-271	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-52
16998321-13	2006	Increased transcription of COX-2 also leads to excessive production of PGE2 that in turn forms a stimulatory loop with many biologic functions (proliferation, migration, invasion, angiogenesis, and inhibition of apoptosis), which may result in the development of CRC.	Dinoprostone	71-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-32
16603590-8	2006	Inhibition of COX-2, but not COX-1, attenuated the cyclic stretch-induced PG increase in the media, suggesting that cyclic stretch primarily affected PG synthesis.	Prostaglandins	74-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
16603590-8	2006	Inhibition of COX-2, but not COX-1, attenuated the cyclic stretch-induced PG increase in the media, suggesting that cyclic stretch primarily affected PG synthesis.	Prostaglandins	150-152	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
17094434-1	2006	BACKGROUND: Celecoxib, a selective cyclooxygenase (COX)-2 inhibitor, has a pro-apoptotic effect on colon adenocarcinoma cells via COX-independent mechanisms.	Celecoxib	12-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-57
17094434-7	2006	The COX-2 inhibitory effect of TT101 was weaker than that of celecoxib.	N-(2-aminoethyl)-4-(5-(4-tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide	31-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
16962824-2	2006	In the current study, conjugated nonadecadienoic acid (CNA) was shown to decrease inducible COX-2 protein and mRNA and PGE(2) release to the similar extent as 10t, 12c-CLA in Raw264.7 macrophage.	SCHEMBL1614406	33-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-97
16962824-2	2006	In the current study, conjugated nonadecadienoic acid (CNA) was shown to decrease inducible COX-2 protein and mRNA and PGE(2) release to the similar extent as 10t, 12c-CLA in Raw264.7 macrophage.	dicloran	55-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-97
16962824-4	2006	The data indicate the regulation of COX-2 by select conjugated fatty acids and hence their anti-inflammatory actions could operate through different signal transduction pathways.	Fatty Acids	63-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-41
16894348-1	2006	BACKGROUND AND PURPOSE: Preliminary results in human mesangial cells (MC) suggested that all-trans retinoic acid (ATRA) increased the expression of COX-2 and the production of prostaglandin E2 (PGE2), a PG with anti-inflammatory effects in MC.	Tretinoin	89-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	148-153
16894348-1	2006	BACKGROUND AND PURPOSE: Preliminary results in human mesangial cells (MC) suggested that all-trans retinoic acid (ATRA) increased the expression of COX-2 and the production of prostaglandin E2 (PGE2), a PG with anti-inflammatory effects in MC.	Tretinoin	114-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	148-153
16894348-2	2006	The aim of this work is to confirm that ATRA increases the expression of COX-2 in MC and to examine the mechanisms involved.	Tretinoin	40-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-78
16894348-7	2006	COX-2 played a role in PGE2 production as production was only partially inhibited by COX-1 inhibitor SC-560.	Dinoprostone	23-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
16894348-7	2006	COX-2 played a role in PGE2 production as production was only partially inhibited by COX-1 inhibitor SC-560.	SC 560	101-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
16894348-8	2006	COX-2 up-regulation by ATRA was due to transcriptional mechanisms as pre-incubation with actinomycin D abolished it and ATRA increased the expression of COX-2 mRNA and the activity of a human COX-2 promoter construct, whereas post-transcriptional mechanisms were not found.	Tretinoin	23-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
16894348-8	2006	COX-2 up-regulation by ATRA was due to transcriptional mechanisms as pre-incubation with actinomycin D abolished it and ATRA increased the expression of COX-2 mRNA and the activity of a human COX-2 promoter construct, whereas post-transcriptional mechanisms were not found.	Tretinoin	23-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	153-158
16894348-8	2006	COX-2 up-regulation by ATRA was due to transcriptional mechanisms as pre-incubation with actinomycin D abolished it and ATRA increased the expression of COX-2 mRNA and the activity of a human COX-2 promoter construct, whereas post-transcriptional mechanisms were not found.	Tretinoin	23-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	153-158
16894348-8	2006	COX-2 up-regulation by ATRA was due to transcriptional mechanisms as pre-incubation with actinomycin D abolished it and ATRA increased the expression of COX-2 mRNA and the activity of a human COX-2 promoter construct, whereas post-transcriptional mechanisms were not found.	Dactinomycin	89-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
16894348-8	2006	COX-2 up-regulation by ATRA was due to transcriptional mechanisms as pre-incubation with actinomycin D abolished it and ATRA increased the expression of COX-2 mRNA and the activity of a human COX-2 promoter construct, whereas post-transcriptional mechanisms were not found.	Dactinomycin	89-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	153-158
16894348-8	2006	COX-2 up-regulation by ATRA was due to transcriptional mechanisms as pre-incubation with actinomycin D abolished it and ATRA increased the expression of COX-2 mRNA and the activity of a human COX-2 promoter construct, whereas post-transcriptional mechanisms were not found.	Dactinomycin	89-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	153-158
16894348-8	2006	COX-2 up-regulation by ATRA was due to transcriptional mechanisms as pre-incubation with actinomycin D abolished it and ATRA increased the expression of COX-2 mRNA and the activity of a human COX-2 promoter construct, whereas post-transcriptional mechanisms were not found.	Tretinoin	120-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
16894348-8	2006	COX-2 up-regulation by ATRA was due to transcriptional mechanisms as pre-incubation with actinomycin D abolished it and ATRA increased the expression of COX-2 mRNA and the activity of a human COX-2 promoter construct, whereas post-transcriptional mechanisms were not found.	Tretinoin	120-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	153-158
16894348-8	2006	COX-2 up-regulation by ATRA was due to transcriptional mechanisms as pre-incubation with actinomycin D abolished it and ATRA increased the expression of COX-2 mRNA and the activity of a human COX-2 promoter construct, whereas post-transcriptional mechanisms were not found.	Tretinoin	120-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	153-158
16894348-10	2006	Instead ATRA might act through a sustained activation of extracellular signal-regulated kinase 1/2 (ERK1/2) since up-regulation of COX-2 was prevented by inhibition of the activation of ERK1/2 with PD098059.	Tretinoin	8-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-136
16934053-0	2006	The effect of the withdrawal of rofecoxib on prescribing patterns of COX-2 inhibitors in Scotland.	rofecoxib	32-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-74
16934053-3	2006	AIMS &amp; METHODS: We set out to examine the effect of the withdrawal of rofecoxib on the prescription of other COX-2 inhibitors and nonselective nonsteroidal anti-inflammatory drugs (nsNSAIDs) in Scotland, using a national prescription database.	rofecoxib	74-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-118
16934053-6	2006	A parallel increase in the prescription of diclofenac and ibuprofen was also noted, suggesting that prescribers were prescribing these medications as alternatives to COX-2 inhibitors.	Diclofenac	43-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	166-171
16934053-6	2006	A parallel increase in the prescription of diclofenac and ibuprofen was also noted, suggesting that prescribers were prescribing these medications as alternatives to COX-2 inhibitors.	Ibuprofen	58-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	166-171
16740977-12	2006	We conclude that leptin stimulates cell proliferation and inhibits apoptosis in OAC cells via ERK, p38 MAPK, phosphatidylinositol 3"-kinase/Akt, and JAK2-dependent activation of COX-2 and PGE2 production.	Dinoprostone	188-192	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	178-183
16926398-4	2006	In the vasculature, HO regulates the cyclooxygenase (COX) enzymes, among which the inducible isozyme COX-2 facilitates the synthesis of prostaglandins (PGs).	Prostaglandins	136-150	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-106
16926398-4	2006	In the vasculature, HO regulates the cyclooxygenase (COX) enzymes, among which the inducible isozyme COX-2 facilitates the synthesis of prostaglandins (PGs).	Prostaglandins	152-155	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-106
16926398-7	2006	R. rickettsii-induced COX-2 was sensitive to inhibitors of de novo transcription and the pyridinylimidazole-based compound SB 203580, suggesting that this transcriptional host cell response involves signaling through p38 mitogen-activated protein kinase.	CHEMBL96741	89-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-27
16926398-7	2006	R. rickettsii-induced COX-2 was sensitive to inhibitors of de novo transcription and the pyridinylimidazole-based compound SB 203580, suggesting that this transcriptional host cell response involves signaling through p38 mitogen-activated protein kinase.	SB 203580	123-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-27
16926398-8	2006	PG production by infected cells was abrogated by NS 398 (a selective COX-2 inhibitor) and indomethacin (a pan-COX inhibitor).	Prostaglandins	0-2	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-74
16926398-8	2006	PG production by infected cells was abrogated by NS 398 (a selective COX-2 inhibitor) and indomethacin (a pan-COX inhibitor).	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	49-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-74
16926398-10	2006	Induction of the endothelial COX-2 system and the resultant enhanced release of vasoactive PGs may contribute to the regulation of inflammatory responses and vascular permeability changes during spotted fever rickettsioses.	Prostaglandins	91-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34
16960420-2	2006	Nicotine is reported to induce prostaglandin E(2) (PGE(2)) production in monocytes through the up-regulation of cyclooxygenase (COX)-2 expression.	Nicotine	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-134
16960420-2	2006	Nicotine is reported to induce prostaglandin E(2) (PGE(2)) production in monocytes through the up-regulation of cyclooxygenase (COX)-2 expression.	Dinoprostone	31-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-134
16960420-2	2006	Nicotine is reported to induce prostaglandin E(2) (PGE(2)) production in monocytes through the up-regulation of cyclooxygenase (COX)-2 expression.	Dinoprostone	51-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-134
16960420-4	2006	COX-2 and PKA inhibitors prevented the action of nicotine, indicating that the mechanism of action of nicotine may be via endogenous PGE(2) production.	Nicotine	49-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
16960420-4	2006	COX-2 and PKA inhibitors prevented the action of nicotine, indicating that the mechanism of action of nicotine may be via endogenous PGE(2) production.	Nicotine	102-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
16960420-4	2006	COX-2 and PKA inhibitors prevented the action of nicotine, indicating that the mechanism of action of nicotine may be via endogenous PGE(2) production.	Dinoprostone	133-139	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
16900533-1	2006	BACKGROUND AND OBJECTIVES: It has been recognized that inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX-2) produce important endogenous factors of human tumors such as nitric oxide (NO) and prostaglandins, which is involved in the process of carcinogenesis and tumor progression.	Nitric Oxide	65-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-119
16900533-1	2006	BACKGROUND AND OBJECTIVES: It has been recognized that inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX-2) produce important endogenous factors of human tumors such as nitric oxide (NO) and prostaglandins, which is involved in the process of carcinogenesis and tumor progression.	Prostaglandins	204-218	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-119
16820795-10	2006	This increased COX-2 expression was associated with increased urinary prostaglandin E2 (PGE2) excretion after release of obstruction.	Dinoprostone	70-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-20
16820795-10	2006	This increased COX-2 expression was associated with increased urinary prostaglandin E2 (PGE2) excretion after release of obstruction.	Dinoprostone	88-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-20
16820795-13	2006	Systemic treatment with the COX-2 selective inhibitor parecoxib (5 mg/kg/day) attenuated the pelvic pressure increase during obstruction.	parecoxib	54-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
17017983-1	2006	Meloxicam was launched as a major new NSAID for the treatment of arthritis following extensive published research confirming its selectivity for COX-2.	Meloxicam	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-150
17017983-11	2006	In contrast lornoxicam and meloxicam, which demonstrated activity against COX-2, have revealed smaller partition capacity in liposomes/water systems together with a higher ability to change the membrane fluidity and surface potential.	lornoxicam	12-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
17017983-11	2006	In contrast lornoxicam and meloxicam, which demonstrated activity against COX-2, have revealed smaller partition capacity in liposomes/water systems together with a higher ability to change the membrane fluidity and surface potential.	Meloxicam	27-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
17017983-11	2006	In contrast lornoxicam and meloxicam, which demonstrated activity against COX-2, have revealed smaller partition capacity in liposomes/water systems together with a higher ability to change the membrane fluidity and surface potential.	Water	135-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
16998619-1	2006	The objective of this study was to compare the pre-emptive analgesic effect of rofecoxib, a cyclooxygenase (COX)-2 inhibitor, with a more traditional and commonly used analgesic, ibuprofen, for mandibular third molar surgery, utilizing a prospective, randomized, double-blind, placebo-controlled clinical trial.	rofecoxib	79-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-114
16455289-2	2006	This method is based on the fact that both Co(II) and Cr(III) catalyze the luminol-H(2)O(2) CL reaction, and that their catalytic activities are significantly different on the same reaction condition.	Luminol	75-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-49
16455289-2	2006	This method is based on the fact that both Co(II) and Cr(III) catalyze the luminol-H(2)O(2) CL reaction, and that their catalytic activities are significantly different on the same reaction condition.	h(2)o(2) cl	83-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-49
16455289-6	2006	The proposed method offers the potential advantages of high sensitivity, simplicity and rapidity for Co(II) and Cr(III) determination, and was successfully applied to the simultaneous determination of both analytes in real water sample.	Water	223-228	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-107
16876468-1	2006	Ternary complexes of Co(II), Ni(II) and Cu(II) with indole-2-carboxylic acid (A) and 4-substituted hydrazinethiocarbamide (L) [4-phenylhydrazinethiocarbamide (L(1)), 4-benzylhydrazinethiocarbamide (L(2)) and 4-(2-propenyl)hydrazinethiocarb-amide (L(3)) were prepared.	indole-2-carboxylic acid	52-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-27
16876468-1	2006	Ternary complexes of Co(II), Ni(II) and Cu(II) with indole-2-carboxylic acid (A) and 4-substituted hydrazinethiocarbamide (L) [4-phenylhydrazinethiocarbamide (L(1)), 4-benzylhydrazinethiocarbamide (L(2)) and 4-(2-propenyl)hydrazinethiocarb-amide (L(3)) were prepared.	4-substituted hydrazinethiocarbamide	85-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-27
16958516-3	2006	The peroxy diols and their acetonide derivatives were also ring-opened with Co(II) salen complexes to give novel hydroxy ketones in 77-100% yield, including the natural sugar psicose.	hydroxy ketones	113-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-82
16958516-3	2006	The peroxy diols and their acetonide derivatives were also ring-opened with Co(II) salen complexes to give novel hydroxy ketones in 77-100% yield, including the natural sugar psicose.	sugar psicose	169-182	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-82
16958516-4	2006	Importantly, preliminary work on the catalytic asymmetric ring-opening of meso-peroxy diols using the Co(II) Jacobsens"s catalyst indicates that asymmetric sugar synthesis from 1,2-dioxines is possible.	meso-peroxy diols	74-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-108
16876468-1	2006	Ternary complexes of Co(II), Ni(II) and Cu(II) with indole-2-carboxylic acid (A) and 4-substituted hydrazinethiocarbamide (L) [4-phenylhydrazinethiocarbamide (L(1)), 4-benzylhydrazinethiocarbamide (L(2)) and 4-(2-propenyl)hydrazinethiocarb-amide (L(3)) were prepared.	-phenylhydrazinethiocarbamide	128-157	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-27
16958516-4	2006	Importantly, preliminary work on the catalytic asymmetric ring-opening of meso-peroxy diols using the Co(II) Jacobsens"s catalyst indicates that asymmetric sugar synthesis from 1,2-dioxines is possible.	Sugars	156-161	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-108
16876468-1	2006	Ternary complexes of Co(II), Ni(II) and Cu(II) with indole-2-carboxylic acid (A) and 4-substituted hydrazinethiocarbamide (L) [4-phenylhydrazinethiocarbamide (L(1)), 4-benzylhydrazinethiocarbamide (L(2)) and 4-(2-propenyl)hydrazinethiocarb-amide (L(3)) were prepared.	4-benzylhydrazinethiocarbamide	166-196	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-27
16958516-4	2006	Importantly, preliminary work on the catalytic asymmetric ring-opening of meso-peroxy diols using the Co(II) Jacobsens"s catalyst indicates that asymmetric sugar synthesis from 1,2-dioxines is possible.	1,2-dioxines	177-189	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-108
16876468-1	2006	Ternary complexes of Co(II), Ni(II) and Cu(II) with indole-2-carboxylic acid (A) and 4-substituted hydrazinethiocarbamide (L) [4-phenylhydrazinethiocarbamide (L(1)), 4-benzylhydrazinethiocarbamide (L(2)) and 4-(2-propenyl)hydrazinethiocarb-amide (L(3)) were prepared.	4-(2-propenyl)hydrazinethiocarb-amide	208-245	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-27
16876468-3	2006	An octahedral structure is suggested for Co(II), Ni(II) and Cu(II) ternary complexes.	cu(ii)	60-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-47
16809336-3	2006	The current study demonstrated that exposure of human bronchial epithelial cells (Beas-2B) to arsenite resulted in a marked induction of cyclooxygenase (COX)-2, an important mediator for inflammation and tumor promotion.	arsenite	94-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-159
16809336-6	2006	Site-directed mutation of two putative NFAT binding sites between-111 to +65 in the COX-2 promoter region eliminated the COX-2 transcriptional activity induced by arsenite, confirming that those two NFAT binding sites in the COX-2 promoter region are critical for COX-2 induction by arsenite.	arsenite	163-171	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-89
16809336-6	2006	Site-directed mutation of two putative NFAT binding sites between-111 to +65 in the COX-2 promoter region eliminated the COX-2 transcriptional activity induced by arsenite, confirming that those two NFAT binding sites in the COX-2 promoter region are critical for COX-2 induction by arsenite.	arsenite	163-171	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-126
16809336-6	2006	Site-directed mutation of two putative NFAT binding sites between-111 to +65 in the COX-2 promoter region eliminated the COX-2 transcriptional activity induced by arsenite, confirming that those two NFAT binding sites in the COX-2 promoter region are critical for COX-2 induction by arsenite.	arsenite	163-171	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-126
16809336-6	2006	Site-directed mutation of two putative NFAT binding sites between-111 to +65 in the COX-2 promoter region eliminated the COX-2 transcriptional activity induced by arsenite, confirming that those two NFAT binding sites in the COX-2 promoter region are critical for COX-2 induction by arsenite.	arsenite	163-171	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-126
16809336-6	2006	Site-directed mutation of two putative NFAT binding sites between-111 to +65 in the COX-2 promoter region eliminated the COX-2 transcriptional activity induced by arsenite, confirming that those two NFAT binding sites in the COX-2 promoter region are critical for COX-2 induction by arsenite.	arsenite	283-291	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-89
16809336-6	2006	Site-directed mutation of two putative NFAT binding sites between-111 to +65 in the COX-2 promoter region eliminated the COX-2 transcriptional activity induced by arsenite, confirming that those two NFAT binding sites in the COX-2 promoter region are critical for COX-2 induction by arsenite.	arsenite	283-291	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-126
16809336-6	2006	Site-directed mutation of two putative NFAT binding sites between-111 to +65 in the COX-2 promoter region eliminated the COX-2 transcriptional activity induced by arsenite, confirming that those two NFAT binding sites in the COX-2 promoter region are critical for COX-2 induction by arsenite.	arsenite	283-291	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-126
16809336-6	2006	Site-directed mutation of two putative NFAT binding sites between-111 to +65 in the COX-2 promoter region eliminated the COX-2 transcriptional activity induced by arsenite, confirming that those two NFAT binding sites in the COX-2 promoter region are critical for COX-2 induction by arsenite.	arsenite	283-291	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-126
16809336-7	2006	Moreover, knockdown of COX-2 expression by COX-2-specific small interference RNA also led to an increased cell apoptosis in Beas-2B cells upon arsenite exposure.	arsenite	143-151	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-28
16809336-7	2006	Moreover, knockdown of COX-2 expression by COX-2-specific small interference RNA also led to an increased cell apoptosis in Beas-2B cells upon arsenite exposure.	arsenite	143-151	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
16809336-8	2006	Together, our results demonstrate that COX-2 induction by arsenite is through NFAT3-dependent and AP-1- or NFkappaB-independent pathways and plays a crucial role in antagonizing arsenite-induced cell apoptosis in human bronchial epithelial Beas-2B cells.	arsenite	58-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-44
16809336-8	2006	Together, our results demonstrate that COX-2 induction by arsenite is through NFAT3-dependent and AP-1- or NFkappaB-independent pathways and plays a crucial role in antagonizing arsenite-induced cell apoptosis in human bronchial epithelial Beas-2B cells.	arsenite	178-186	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-44
16937518-8	2006	In tumors, overexpression of COX-2 leads to an increase in prostaglandin (PG) levels, which affect many mechanisms involved in carcinogenesis, such as angiogenesis, inhibition of apoptosis, stimulation of cell growth as well as the invasiveness and metastatic potential of tumor cells.	Prostaglandins	59-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34
16937518-8	2006	In tumors, overexpression of COX-2 leads to an increase in prostaglandin (PG) levels, which affect many mechanisms involved in carcinogenesis, such as angiogenesis, inhibition of apoptosis, stimulation of cell growth as well as the invasiveness and metastatic potential of tumor cells.	Prostaglandins	74-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34
16243430-7	2006	COX-2-specific inhibitor-NS398 inhibited the growth of human gastric cancer SC-M1 cells as well as HGF stimulated the growth of SC-M1 cells in a dose-dependent manner.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	25-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
16794187-9	2006	The antimitotic effects of 2-ME on SMCs are mediated by the inhibition of key cell-cycle regulatory proteins and effects on tubulin polymerization and COX-2 upregulation.	2-Methoxyestradiol	27-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-156
16473862-4	2006	We show here that COX-2-dependent production of prostacyclin plays an important role in the development of fibrotic lung disease, limiting both the development of fibrosis and the consequential alterations in lung mechanics.	Epoprostenol	48-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-23
16878866-5	2006	Moreover, with the presence of Co(II) (1.0 x 10(-4) mol/L) in the mobile phase, the linear range of the concentration for luminol was 2.0 x 10(-9)-2.0 x 10(-6) mol/L with a detection limit (S/N = 3) of 2.0 x 10(-10) mol/L, and 2.5 x 10(4) theoretical plates was achieved.	Luminol	122-129	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-37
16476713-11	2006	These data suggest that PGE(2) blocking agents may decrease PGE(2) production not only by direct COX-2 inhibition but also by down regulating COX-2 expression and synthesis.	Prostaglandins E	24-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
16476713-11	2006	These data suggest that PGE(2) blocking agents may decrease PGE(2) production not only by direct COX-2 inhibition but also by down regulating COX-2 expression and synthesis.	Prostaglandins E	24-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	142-147
16476713-11	2006	These data suggest that PGE(2) blocking agents may decrease PGE(2) production not only by direct COX-2 inhibition but also by down regulating COX-2 expression and synthesis.	Dinoprostone	24-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
16476713-11	2006	These data suggest that PGE(2) blocking agents may decrease PGE(2) production not only by direct COX-2 inhibition but also by down regulating COX-2 expression and synthesis.	Dinoprostone	24-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	142-147
16699954-7	2006	Moreover, the use of a specific COX-2 inhibitor (NS 398) in the experimental models showed that COX-2 hyperexpression could partially explain the resistance mechanisms to NCX 4040.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	49-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-37
16699954-7	2006	Moreover, the use of a specific COX-2 inhibitor (NS 398) in the experimental models showed that COX-2 hyperexpression could partially explain the resistance mechanisms to NCX 4040.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	49-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-101
16858202-0	2006	Prevention of intra-abdominal adhesions using the antiangiogenic COX-2 inhibitor celecoxib.	Celecoxib	81-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-70
16824926-10	2006	Downregulation of COX-2 protein expression caused by celecoxib was observed in SKOV3 cells.	Celecoxib	53-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-23
16635574-1	2006	A group of regioisomeric phenylethynylbenzenesulfonamides possessing a COX-2 SO2NH2 pharmacophore at the para-, meta- or ortho-position of the C-1 phenyl ring, in conjunction with a C-2 substituted-phenyl (H, OMe, OH, Me, F) group, were synthesized and evaluated as inhibitors of the cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) isozymes.	phenylethynylbenzenesulfonamide	25-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-76
16635574-1	2006	A group of regioisomeric phenylethynylbenzenesulfonamides possessing a COX-2 SO2NH2 pharmacophore at the para-, meta- or ortho-position of the C-1 phenyl ring, in conjunction with a C-2 substituted-phenyl (H, OMe, OH, Me, F) group, were synthesized and evaluated as inhibitors of the cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) isozymes.	phenylethynylbenzenesulfonamide	25-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	331-336
16635574-1	2006	A group of regioisomeric phenylethynylbenzenesulfonamides possessing a COX-2 SO2NH2 pharmacophore at the para-, meta- or ortho-position of the C-1 phenyl ring, in conjunction with a C-2 substituted-phenyl (H, OMe, OH, Me, F) group, were synthesized and evaluated as inhibitors of the cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) isozymes.	so2nh2	77-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-76
16635574-3	2006	In vitro COX-1/-2 isozyme inhibition structure-activity data showed that COX-1/-2 inhibition and the COX selectivity index (SI) are sensitive to the regioisomeric placement of the COX-2 SO2NH2 pharmacophore where the COX-2 potency order for the benzenesulfonamide regioisomers was generally meta&gt;para and ortho.	so2nh2	186-192	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	180-185
16635574-3	2006	In vitro COX-1/-2 isozyme inhibition structure-activity data showed that COX-1/-2 inhibition and the COX selectivity index (SI) are sensitive to the regioisomeric placement of the COX-2 SO2NH2 pharmacophore where the COX-2 potency order for the benzenesulfonamide regioisomers was generally meta&gt;para and ortho.	so2nh2	186-192	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	217-222
16635574-3	2006	In vitro COX-1/-2 isozyme inhibition structure-activity data showed that COX-1/-2 inhibition and the COX selectivity index (SI) are sensitive to the regioisomeric placement of the COX-2 SO2NH2 pharmacophore where the COX-2 potency order for the benzenesulfonamide regioisomers was generally meta&gt;para and ortho.	benzenesulfonamide	245-263	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	180-185
16635574-4	2006	Among this group of compounds, the in vitro COX-1/-2 isozyme inhibition studies identified 3-(2-phenylethynyl)benzenesulfonamide (10a) as a COX-2 inhibitor (COX-2 IC50=0.45 microM) with a good COX-2 selectivity (COX-2 SI=70).	3-(2-phenylethynyl)benzenesulfonamide	91-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-145
16635574-4	2006	Among this group of compounds, the in vitro COX-1/-2 isozyme inhibition studies identified 3-(2-phenylethynyl)benzenesulfonamide (10a) as a COX-2 inhibitor (COX-2 IC50=0.45 microM) with a good COX-2 selectivity (COX-2 SI=70).	3-(2-phenylethynyl)benzenesulfonamide	91-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	157-162
16635574-4	2006	Among this group of compounds, the in vitro COX-1/-2 isozyme inhibition studies identified 3-(2-phenylethynyl)benzenesulfonamide (10a) as a COX-2 inhibitor (COX-2 IC50=0.45 microM) with a good COX-2 selectivity (COX-2 SI=70).	3-(2-phenylethynyl)benzenesulfonamide	91-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	157-162
16635574-4	2006	Among this group of compounds, the in vitro COX-1/-2 isozyme inhibition studies identified 3-(2-phenylethynyl)benzenesulfonamide (10a) as a COX-2 inhibitor (COX-2 IC50=0.45 microM) with a good COX-2 selectivity (COX-2 SI=70).	3-(2-phenylethynyl)benzenesulfonamide	91-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	157-162
16635574-5	2006	In contrast, 2-[2-(3-fluorophenyl)ethynyl]benzenesulfonamide (11c) possessing a SO2NH2 COX-2 pharmacophore at the ortho-position of the C-1 phenyl ring exhibited COX-1 inhibition and selectivity (COX-1 IC50=3.6 microM).	2-[2-(3-fluorophenyl)ethynyl]benzenesulfonamide	13-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-92
16635574-5	2006	In contrast, 2-[2-(3-fluorophenyl)ethynyl]benzenesulfonamide (11c) possessing a SO2NH2 COX-2 pharmacophore at the ortho-position of the C-1 phenyl ring exhibited COX-1 inhibition and selectivity (COX-1 IC50=3.6 microM).	Carbon-11	62-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-92
16635574-5	2006	In contrast, 2-[2-(3-fluorophenyl)ethynyl]benzenesulfonamide (11c) possessing a SO2NH2 COX-2 pharmacophore at the ortho-position of the C-1 phenyl ring exhibited COX-1 inhibition and selectivity (COX-1 IC50=3.6 microM).	so2nh2	80-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-92
16635574-7	2006	Similar docking of 10a within the COX-1 binding site shows that the meta-SO2NH2 pharmacophore is unable to interact with the respective amino acid residues in COX-1 that correspond to those near the secondary pocket in COX-2 due to the presence of the larger Ile523 in COX-1 that replaces Val523 in COX-2.	meta-so2nh2	68-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	219-224
16635574-7	2006	Similar docking of 10a within the COX-1 binding site shows that the meta-SO2NH2 pharmacophore is unable to interact with the respective amino acid residues in COX-1 that correspond to those near the secondary pocket in COX-2 due to the presence of the larger Ile523 in COX-1 that replaces Val523 in COX-2.	meta-so2nh2	68-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	299-304
16730986-0	2006	N-acylated sulfonamide sodium salt: a prodrug of choice for the bifunctional 2-hydroxymethyl-4-(5-phenyl-3-trifluoromethyl-pyrazol-1-yl) benzenesulfonamide class of COX-2 inhibitors.	n-acylated sulfonamide sodium salt	0-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	165-170
16730986-0	2006	N-acylated sulfonamide sodium salt: a prodrug of choice for the bifunctional 2-hydroxymethyl-4-(5-phenyl-3-trifluoromethyl-pyrazol-1-yl) benzenesulfonamide class of COX-2 inhibitors.	2-hydroxymethyl-4-(5-phenyl-3-trifluoromethyl-pyrazol-1-yl) benzenesulfonamide	77-155	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	165-170
16730986-1	2006	Synthesis and biological evaluation of possible prodrugs of COX-2 inhibitors involving sulfonamide and hydroxymethyl groups of 2-hydroxymethyl-4-(5-phenyl-3-trifluoromethyl-pyrazol-1-yl) benzenesulfonamides are described.	Sulfonamides	87-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-65
16730986-1	2006	Synthesis and biological evaluation of possible prodrugs of COX-2 inhibitors involving sulfonamide and hydroxymethyl groups of 2-hydroxymethyl-4-(5-phenyl-3-trifluoromethyl-pyrazol-1-yl) benzenesulfonamides are described.	2-hydroxymethyl-4-(5-phenyl-3-trifluoromethyl-pyrazol-1-yl) benzenesulfonamides	127-206	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-65
16859832-0	2006	Mediators of PGE2 synthesis and signalling downstream of COX-2 represent potential targets for the prevention/treatment of colorectal cancer.	Dinoprostone	13-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-62
16859832-4	2006	COX enzymes represent the committed step in prostaglandin biosynthesis and it is predominantly increased COX-2-mediated prostaglandin-E2 (PGE2) production that has a strong association with colorectal neoplasia, by promoting cell survival, cell growth, migration, invasion and angiogenesis.	Dinoprostone	120-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-110
16859832-4	2006	COX enzymes represent the committed step in prostaglandin biosynthesis and it is predominantly increased COX-2-mediated prostaglandin-E2 (PGE2) production that has a strong association with colorectal neoplasia, by promoting cell survival, cell growth, migration, invasion and angiogenesis.	Dinoprostone	138-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-110
16859832-5	2006	COX-1 and COX-2 inhibition by traditional NSAIDs (for example, aspirin) although chemopreventive have some side effects due to the role of COX-1 in maintaining the integrity of the gastric mucosa.	Aspirin	63-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
16918401-3	2006	Non-steroidal anti-inflammatory drugs (NSAIDs) including COX-2 inhibitors although devoid of steroid side effects often possess gastrointestinal side effects.	Steroids	4-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-62
16848690-2	2006	In this review, the authors demonstrate the upregulation of COX-2/prostaglandin E2, IL-6 and calcitonin gene-related peptide in invading macrophages and discuss possible mechanisms involved in their upregulation and how they contribute to the maintenance of neuropathic pain.	Dinoprostone	66-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-65
16506214-1	2006	COX-2 is a key enzyme in the conversion of arachidonic acid to prostaglandins.	Arachidonic Acid	43-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
16506214-1	2006	COX-2 is a key enzyme in the conversion of arachidonic acid to prostaglandins.	Prostaglandins	63-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
16506214-2	2006	The prostaglandins produced by COX-2 are involved in inflammation and pain response in different tissues in the body.	Prostaglandins	4-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-36
16646088-8	2006	Moreover, both fatty acids were able to induce COX-2 expression.	Fatty Acids	15-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
16861295-8	2006	These results suggest that the inhibitory effects of clodronate on tooth movement and osteoclasts may be due, at least in part, to the inhibition of COX-2-dependent PGE(2) production and RANKL expression in PDL cells.	Clodronic Acid	53-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	149-154
16861295-8	2006	These results suggest that the inhibitory effects of clodronate on tooth movement and osteoclasts may be due, at least in part, to the inhibition of COX-2-dependent PGE(2) production and RANKL expression in PDL cells.	Prostaglandins E	165-168	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	149-154
16927600-0	2006	[Latanoprost induced COX2 during aqueous humor formation].	Latanoprost	1-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-25
16960142-3	2006	Epilipoxins, for instance, are produced from aspirin"s acetylation of COX-2 and together with Resolvins and COX-2-derived prostaglandins of the D(2) and J(2) series represent an increasingly important family of immunoregulatory lipid mediators with strong implications for disease control and drug discovery.	Aspirin	45-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-75
16960142-3	2006	Epilipoxins, for instance, are produced from aspirin"s acetylation of COX-2 and together with Resolvins and COX-2-derived prostaglandins of the D(2) and J(2) series represent an increasingly important family of immunoregulatory lipid mediators with strong implications for disease control and drug discovery.	Prostaglandins	122-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-113
16738877-8	2006	However, the non-selective cyclooxygenase (COX) inhibitor, indomethacin (10 and 30 microM), and the COX-2 selective inhibitor, NS-398 (3, 10 and 30 microM) produced inhibitory effects on 15-E2t-IsoP-induced contraction of HUV rings with endothelium.	15-e2t	187-193	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-105
16738877-10	2006	Furthermore, the apparent pKb values estimated for indomethacin (5.5) and NS-398 (5.4) suggest that the prostanoids involved are derived from the COX-2 isoenzyme pathway.	Indomethacin	51-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	146-151
16738877-10	2006	Furthermore, the apparent pKb values estimated for indomethacin (5.5) and NS-398 (5.4) suggest that the prostanoids involved are derived from the COX-2 isoenzyme pathway.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	74-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	146-151
16738877-10	2006	Furthermore, the apparent pKb values estimated for indomethacin (5.5) and NS-398 (5.4) suggest that the prostanoids involved are derived from the COX-2 isoenzyme pathway.	Prostaglandins	104-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	146-151
16738877-15	2006	We conclude that prostanoids derived from the COX-2 isoenzyme pathway participate in 15-E2t-IsoP-induced vasoconstriction of isolated HUV rings.	Prostaglandins	17-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
16738877-15	2006	We conclude that prostanoids derived from the COX-2 isoenzyme pathway participate in 15-E2t-IsoP-induced vasoconstriction of isolated HUV rings.	15-e2t	85-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
16820896-1	2006	COX-2 is upregulated in many breast tumors, and one of the products of COX-2 is PGE2 that is suggested to upregulate aromatase through cAMP signaling in breast cancer.	Dinoprostone	80-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-76
16820896-1	2006	COX-2 is upregulated in many breast tumors, and one of the products of COX-2 is PGE2 that is suggested to upregulate aromatase through cAMP signaling in breast cancer.	Cyclic AMP	135-139	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
16820896-1	2006	COX-2 is upregulated in many breast tumors, and one of the products of COX-2 is PGE2 that is suggested to upregulate aromatase through cAMP signaling in breast cancer.	Cyclic AMP	135-139	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-76
16820896-9	2006	COX-2 expression correlates with the levels of the examined steroid converting enzymes and may contribute to increased estrogen levels in the tumor.	Steroids	60-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
16387430-4	2006	Molecular modeling techniques are used to gain information about the stability of different Co(II) species as a function of pH, as well as the stability of Co(II) species complexed with benzoic acid, a common surface component of humic substances.	Benzoic Acid	186-198	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	156-162
16848520-5	2006	In COX enzyme inhibitory assays, ferulic and caffeic acid esters significantly inhibited both COX-1 and COX-2 enzymes.	caffeic acid esters	45-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
16683279-4	2006	The determined spin arrangement is consistent with the magnetic intratetramer interactions suggested previously from the analysis of magnetic susceptibility data: the magnetic moments of the central Co(III) ions of the Co(4)O(10) tetramer lie parallel to each other and couple in an antiparallel fashion to the terminal Co(II) moments.	co(4)	219-224	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	320-326
16916451-7	2006	In this article, we discuss that inhibition of COX2 reduces PG synthesis and renders beneficial effects by preventing sensitization of nociceptors, but at the same time, it might contribute to deleterious cardiovascular effects by compromising the synthesis and/or release of vasoactive agents.	Prostaglandins	60-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-51
16557574-3	2006	We examined whether bile acids induce tumor growth via the cyclooxygenase (COX)-2 angiogenic pathway.	Bile Acids and Salts	20-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-81
16557574-10	2006	In vitro, CDCA induced the production of PGE2 and VEGF in dose- and time-dependent manners, and these effects were attenuated by a selective COX-2 inhibitor, mitogen-activated protein kinases inhibitor, or epidermal growth factor receptor inhibitor.	Chenodeoxycholic Acid	10-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	141-146
16557574-10	2006	In vitro, CDCA induced the production of PGE2 and VEGF in dose- and time-dependent manners, and these effects were attenuated by a selective COX-2 inhibitor, mitogen-activated protein kinases inhibitor, or epidermal growth factor receptor inhibitor.	Dinoprostone	41-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	141-146
16557574-11	2006	CDCA-induced COX-2 in the cell lysate increased the secretion of VEGF into the culture medium.	Chenodeoxycholic Acid	0-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
16557574-14	2006	Our results suggest that bile acids, important constituents of duodenal fluid, stimulate the development of human esophageal cancer by promoting angiogenesis via the COX-2 pathway.	Bile Acids and Salts	25-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	166-171
16794187-6	2006	Moreover, 2-ME augmented COX-2 expression, suggesting that it may also inhibit SMC growth via prostaglandin formation.	2-Methoxyestradiol	10-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-30
16861295-7	2006	Clodronate also strongly inhibited stress-induced gene expression for COX-2 and RANKL.	Clodronic Acid	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-75
16870006-7	2006	The reporter assay indicated that the transactivation of the hCOX-2 promoter was induced by PMA, and activity was inhibited with the co-administration of genistein, daidzein or equol.	Genistein	154-163	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-67
16831226-1	2006	BACKGROUND: Cyclooxygenase (COX) is the rate-limiting enzyme that catalyzes the formation of prostaglandins.	Prostaglandins	93-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-31
16831226-4	2006	It is well established that one of the direct results of COX-2 action is increased prostaglandin production, especially prostaglandin E2 (PGE2).	Prostaglandins	83-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-62
16831226-4	2006	It is well established that one of the direct results of COX-2 action is increased prostaglandin production, especially prostaglandin E2 (PGE2).	Dinoprostone	120-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-62
16831226-4	2006	It is well established that one of the direct results of COX-2 action is increased prostaglandin production, especially prostaglandin E2 (PGE2).	Dinoprostone	138-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-62
16545570-5	2006	On the other hand, in searching for COX-2 inhibitor, the inhibition of plasma PGE2 for the compounds was determined and four compounds were found to be more potent than the reference drug.	Dinoprostone	78-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-41
16023340-2	2006	Eleven out of total 38 isolated fungi which tolerated &gt; 6.0 mM Co(II) were evaluated for cobalt biosorption using dried mycelial biomass.	Cobalt	92-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-72
16023340-3	2006	Maximum Co(II)-loading (1036.5 microM/g, 60 min) was achieved with Mortierella SPS 403 biomass, which removed almost 50% of 4.0 mM cobalt from the aqueous solution.	mortierella sps	67-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	8-14
16023340-3	2006	Maximum Co(II)-loading (1036.5 microM/g, 60 min) was achieved with Mortierella SPS 403 biomass, which removed almost 50% of 4.0 mM cobalt from the aqueous solution.	Cobalt	131-137	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	8-14
16023340-4	2006	Co(II)-sorption kinetics of Mortierella SPS 403 biomass was fast and appreciable quantities of metal [562.5 microM/g] was adsorbed during first 10 min of incubation.	mortierella sps	28-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
16023340-4	2006	Co(II)-sorption kinetics of Mortierella SPS 403 biomass was fast and appreciable quantities of metal [562.5 microM/g] was adsorbed during first 10 min of incubation.	Metals	95-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
16023340-7	2006	However, Co(II)-uptake was inhibited in presence of other metals (Pb, Cd, Cu, Ni, Cr and Zn).	Lead	66-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	9-14
16023340-7	2006	However, Co(II)-uptake was inhibited in presence of other metals (Pb, Cd, Cu, Ni, Cr and Zn).	Cadmium	70-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	9-14
16023340-7	2006	However, Co(II)-uptake was inhibited in presence of other metals (Pb, Cd, Cu, Ni, Cr and Zn).	Copper	74-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	9-14
16023340-7	2006	However, Co(II)-uptake was inhibited in presence of other metals (Pb, Cd, Cu, Ni, Cr and Zn).	Chromium	82-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	9-14
16023340-7	2006	However, Co(II)-uptake was inhibited in presence of other metals (Pb, Cd, Cu, Ni, Cr and Zn).	Zinc	89-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	9-14
16023340-8	2006	Freundlich adsorption isotherm appropriately describes Mortierella SPS 403 biomass as an efficient Co(II)-biosorbent.	mortierella sps	55-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-105
16870006-7	2006	The reporter assay indicated that the transactivation of the hCOX-2 promoter was induced by PMA, and activity was inhibited with the co-administration of genistein, daidzein or equol.	daidzein	165-173	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-67
16870006-7	2006	The reporter assay indicated that the transactivation of the hCOX-2 promoter was induced by PMA, and activity was inhibited with the co-administration of genistein, daidzein or equol.	Equol	177-182	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-67
16870006-8	2006	An activator protein-1 (AP-1)/cyclic AMP response element binding protein (CREB) binding site (-59/-53) was identified in hCOX-2 promoter, and this could be critical in PMA-induced COX-2 expression.	Cyclic AMP	30-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-128
16870006-10	2006	The results revealed that the hCOX-2 promoter transactivation suppressed by isoflavone could be dependent on AP-1/CREB binding.	Isoflavones	76-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-36
16956425-8	2006	Vitamin D stimulated the expression of cox-2 mRNA which was further enhanced by TNF-alpha/IL-1beta.	Vitamin D	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-44
16818638-8	2006	These data indicate that PGDH may serve a tumor suppressor function in colorectal cancer and provide a possible COX-2-independent way to target PGE(2) to inhibit cancer progression.	Prostaglandins E	144-147	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-117
16818642-1	2006	Cyclooxygenase (COX)-2, the inducible key enzyme for prostanoid biosynthesis, is overexpressed in most colorectal carcinomas and a subset of colorectal adenomas.	Prostaglandins	53-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-22
16818642-6	2006	Oligonucleotide pull-down and chromatin immunoprecipitation assays reveal that HIF-1alpha binds a hypoxia-responsive element on the COX-2 promoter.	Oligonucleotides	0-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-137
16818642-7	2006	COX-2 up-regulation during hypoxia is accompanied by increased levels of prostaglandin E(2) (PGE(2)), which promote tumor cell survival under hypoxic conditions.	Dinoprostone	73-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
16818642-7	2006	COX-2 up-regulation during hypoxia is accompanied by increased levels of prostaglandin E(2) (PGE(2)), which promote tumor cell survival under hypoxic conditions.	Dinoprostone	93-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
16818642-8	2006	In addition, elevated levels of PGE(2) in hypoxic colorectal tumor cells enhance vascular endothelial growth factor expression and HIF-1 transcriptional activity by activating the mitogen-activated protein kinase pathway, showing a potential positive feedback loop that contributes to COX-2 up-regulation during hypoxia.	Prostaglandins E	32-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	285-290
16897369-5	2006	Platelet-activating factor (PAF) and COX-2-synthesized PGE(2) modulate synaptic plasticity and memory.	Dinoprostone	55-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-42
16956425-11	2006	CONCLUSION: We found dexamethasone to inhibit the [Ca2+]i increase in MG-63 cells following stimulation and to reduce considerably COX-2 expression via the genomic pathway.	Dexamethasone	21-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-136
16624933-7	2006	Evidence is also presented, using Fe(2)(+)/Cu(2)(+) ions, that hydroxyl radicals generated from hydrogen peroxide through Fenton reactions could constitute candidate modulators able to directly trigger anti-IgE-elicited COX-2 expression through MAPK and NF-kappaB pathways.	Hydrogen Peroxide	96-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	220-225
16574793-5	2006	Seminal plasma and PGE(2) signaling via the EP4 receptor induced the activation of cyclooxygenase (COX)-2 and vascular endothelial growth factor (VEGF) promoters, expression of COX-2 and VEGF mRNA and protein, and secretion of VEGF protein into the culture medium.	Prostaglandins E	19-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-105
16574793-5	2006	Seminal plasma and PGE(2) signaling via the EP4 receptor induced the activation of cyclooxygenase (COX)-2 and vascular endothelial growth factor (VEGF) promoters, expression of COX-2 and VEGF mRNA and protein, and secretion of VEGF protein into the culture medium.	Prostaglandins E	19-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	177-182
16730702-0	2006	Evidence of COX-2 independent induction of apoptosis and cell cycle block in human colon carcinoma cells after S- or R-ibuprofen treatment.	s- or r-ibuprofen	111-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-17
16730702-1	2006	Ibuprofen belongs to the 2-aryl propionic-acid derivatives and consists of two enantiomers, of which S-ibuprofen is a potent cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) inhibitor whereas the R-enantiomer is two to three orders of magnitude less potent to inhibit cyclooxygenases.	Ibuprofen	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	172-177
16730702-1	2006	Ibuprofen belongs to the 2-aryl propionic-acid derivatives and consists of two enantiomers, of which S-ibuprofen is a potent cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) inhibitor whereas the R-enantiomer is two to three orders of magnitude less potent to inhibit cyclooxygenases.	Ibuprofen	103-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	172-177
16859310-0	2006	Ligand coordinate analysis of SC-558 from the active site to the surface of COX-2: a molecular dynamics study.	SC 558	30-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-81
16859310-1	2006	We have performed a ligand coordinate analysis to monitor the movement of the inhibitor SC-558 from the active site of the COX-2 protein to the exterior using molecular dynamics techniques.	SC 558	88-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-128
16859310-3	2006	The published crystal structure of COX-2 with SC-558 in the active site (1cx2) was taken, and the ligand was moved incrementally in 13 steps.	SC 558	46-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40
16624933-0	2006	Modulation of IgE-dependent COX-2 gene expression by reactive oxygen species in human neutrophils.	Reactive Oxygen Species	53-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
16624933-2	2006	Up-regulation of its COX-2 isoform is responsible for the increased PG release, taking place under inflammatory conditions, and also, is thought to be involved in allergic and inflammatory diseases.	Prostaglandins	68-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-26
16624933-5	2006	We also show evidence that inhibitors of reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, such as 4-(2-aminoethyl)benzenesulphonyl fluoride and 4-hydroxy-3-methoxyaceto-phenone, completely cancelled anti-IgE-induced COX-2 protein up-regulation, suggesting that this process is mediated by reactive oxygen species (ROS) derived from NADPH oxidase activity.	4-(2-aminoethyl)benzenesulphonyl fluoride	118-159	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	236-241
16624933-5	2006	We also show evidence that inhibitors of reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, such as 4-(2-aminoethyl)benzenesulphonyl fluoride and 4-hydroxy-3-methoxyaceto-phenone, completely cancelled anti-IgE-induced COX-2 protein up-regulation, suggesting that this process is mediated by reactive oxygen species (ROS) derived from NADPH oxidase activity.	acetovanillone	164-196	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	236-241
16624933-7	2006	Evidence is also presented, using Fe(2)(+)/Cu(2)(+) ions, that hydroxyl radicals generated from hydrogen peroxide through Fenton reactions could constitute candidate modulators able to directly trigger anti-IgE-elicited COX-2 expression through MAPK and NF-kappaB pathways.	ammonium ferrous sulfate	34-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	220-225
16624933-7	2006	Evidence is also presented, using Fe(2)(+)/Cu(2)(+) ions, that hydroxyl radicals generated from hydrogen peroxide through Fenton reactions could constitute candidate modulators able to directly trigger anti-IgE-elicited COX-2 expression through MAPK and NF-kappaB pathways.	cu(2)(+)	43-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	220-225
16624933-7	2006	Evidence is also presented, using Fe(2)(+)/Cu(2)(+) ions, that hydroxyl radicals generated from hydrogen peroxide through Fenton reactions could constitute candidate modulators able to directly trigger anti-IgE-elicited COX-2 expression through MAPK and NF-kappaB pathways.	Hydroxyl Radical	63-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	220-225
16517580-9	2006	CONCLUSIONS: Upregulation in the expression of COX-1 and COX-2 could explain the high production of prostanoids reported in CF.	Prostaglandins	100-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-62
17723397-10	2006	Electron spin resonance (ESR) data indicates that Co(II) metal-ion center of Co-Sal ionophore undergoes oxidation to Co(III).	Metals	57-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-56
16738877-8	2006	However, the non-selective cyclooxygenase (COX) inhibitor, indomethacin (10 and 30 microM), and the COX-2 selective inhibitor, NS-398 (3, 10 and 30 microM) produced inhibitory effects on 15-E2t-IsoP-induced contraction of HUV rings with endothelium.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	127-133	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-105
16810646-3	2006	Electrospray ionization quadrupole ion trap mass spectrometry with collision-induced dissociation (CID) was used to analyze complexes of the form [Co(II) (L-H) (Aux)]+ and [Co(II) (L-H) (Aux)2]+, in which L is the flavonoid glucuronide and Aux is a phenanthroline-based ligand.	Flavonoids	214-223	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-153
16810646-3	2006	Electrospray ionization quadrupole ion trap mass spectrometry with collision-induced dissociation (CID) was used to analyze complexes of the form [Co(II) (L-H) (Aux)]+ and [Co(II) (L-H) (Aux)2]+, in which L is the flavonoid glucuronide and Aux is a phenanthroline-based ligand.	Glucuronides	224-235	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-153
16810646-3	2006	Electrospray ionization quadrupole ion trap mass spectrometry with collision-induced dissociation (CID) was used to analyze complexes of the form [Co(II) (L-H) (Aux)]+ and [Co(II) (L-H) (Aux)2]+, in which L is the flavonoid glucuronide and Aux is a phenanthroline-based ligand.	Phenanthrolines	249-263	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-153
16861876-8	2006	DCA-induced VEGF protein expression was inhibited by pretreatment with NS-398 (COX-2 inhibitor), PDTC (NF-kappaB inhibitor), or tauroursodeoxycholic acid (TUDC).	Deoxycholic Acid	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-84
16861876-8	2006	DCA-induced VEGF protein expression was inhibited by pretreatment with NS-398 (COX-2 inhibitor), PDTC (NF-kappaB inhibitor), or tauroursodeoxycholic acid (TUDC).	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	71-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-84
16806870-2	2006	Rofecoxib, celecoxib, nimesulide, ibuprofen, indomethacin, aspirin, salicylic acid, naproxen and acetaminophen were tested for inhibition of COX-2-mediated prostaglandin E2 synthesis in A549 and AGS cells.	Dinoprostone	156-172	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	141-146
17147112-8	2006	RESULTS: sulindac induced morphologic alterations in BGC-823 cells, inhibited cell proliferation, increased the proportion of cells in G0/G1 phase and decreased the proportion of cells in S phase, induced apoptosis of BGC-823 cells, and decreased expressions of COX-2, bcl-2, ki-67 in the cells.	Sulindac	9-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	262-267
17147112-11	2006	CONCLUSION: sulindac may inhibit the growth of gastric cancer BGC-823 cells in vitro and the anti-tumor mechanism may be related to changes in cell cycle distribution, induction of apoptosis and inhibition of expression of COX-2, bcl-2, and ki-67.	Sulindac	12-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	223-228
16681998-2	2006	Pretreatment of the procyanidin dimer B2 reduced COX-2 expression induced by the endotoxin lipopolysaccharide (LPS) in differentiated human monocytic cells (THP-1) in culture.	procyanidin	20-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-54
16681998-3	2006	To further elucidate the underlying mechanism of COX-2 inhibition by procyanidin, we examined their effects on the activation of extracellular signal-regulated protein kinase (ERK), Jun-terminal kinase (JNK), and p38 mitogen-activated protein kinase (MAPK), which are upstream enzymes known to regulate COX-2 expression in many cell types.	procyanidin	69-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-54
16681998-6	2006	By affecting the expression rather than the activity of COX-2, these in vitro data reported herein give further evidence on the anti-inflammatory protection by procyanidins.	Proanthocyanidins	160-172	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-61
16774214-2	2006	In the complex, the adjacent Co(II) ions are coordinated by mu(1,3)-SCN(-) bridging ligands which forms a one-dimensional chain along the a axis; the one-dimensional chains are further connected by mu(1,6)-dmpzdo bridging ligands which leads to the formation of a two-dimensional layer on the ac plane.	(1,6)-dmpzdo	200-212	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-35
16774214-3	2006	The theoretical calculations reveal that a ferromagnetic coupling exists between the mu(1,3)-SCN(-) bridging Co(II) ions and an anti-ferromagnetic interaction between the mu(1,6)-dmpzdo bridging Co(II) ions, and the anti-ferromagnetic interaction is stronger than the ferromagnetic interaction.	(1,6)-dmpzdo	173-185	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-115
16774214-3	2006	The theoretical calculations reveal that a ferromagnetic coupling exists between the mu(1,3)-SCN(-) bridging Co(II) ions and an anti-ferromagnetic interaction between the mu(1,6)-dmpzdo bridging Co(II) ions, and the anti-ferromagnetic interaction is stronger than the ferromagnetic interaction.	(1,6)-dmpzdo	173-185	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	195-201
16386771-5	2006	Our results show the following: (i) Ni(II), Co(II), V(V), Mn(II), and to a lesser extent As(III) and Cu(II) activated the binding of IRP-1 to IRE after 24 h, while the other metal ions had no effect; (ii) 10 of 12 metal ions induced HIF-1alpha protein but to strikingly different degrees.	Metals	174-179	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-56
16386771-5	2006	Our results show the following: (i) Ni(II), Co(II), V(V), Mn(II), and to a lesser extent As(III) and Cu(II) activated the binding of IRP-1 to IRE after 24 h, while the other metal ions had no effect; (ii) 10 of 12 metal ions induced HIF-1alpha protein but to strikingly different degrees.	Metals	214-219	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-56
16749821-9	2006	The Co(II) centers in the double-cubane complexes [Co4(1-H)6(NO3)2] and [Co4(2-H)6Cl2] are strongly antiferromagnetically coupled to each other at low temperature to give an S = 0 ground state.	co4(1-h)6(no3)2	51-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
16749821-9	2006	The Co(II) centers in the double-cubane complexes [Co4(1-H)6(NO3)2] and [Co4(2-H)6Cl2] are strongly antiferromagnetically coupled to each other at low temperature to give an S = 0 ground state.	co4(2-h)6cl2	73-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
16763169-0	2006	COX-2, another important player in the nitric oxide-endothelin cross-talk: good news for COX-2 inhibitors?	Nitric Oxide	39-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
16763169-0	2006	COX-2, another important player in the nitric oxide-endothelin cross-talk: good news for COX-2 inhibitors?	Nitric Oxide	39-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-94
16624933-8	2006	Present results underscore a new role for ROS as second messengers in the modulation of COX-2 expression by human neutrophils in allergic conditions.	Reactive Oxygen Species	42-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-93
16720448-1	2006	CONCLUSION: In laryngeal cancer, arachidonic acid may be metabolized to PGE2 via the cooperative actions of COX-2 and mPGES, which are induced in response to various stimuli.	Arachidonic Acid	33-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-113
16720448-1	2006	CONCLUSION: In laryngeal cancer, arachidonic acid may be metabolized to PGE2 via the cooperative actions of COX-2 and mPGES, which are induced in response to various stimuli.	Dinoprostone	72-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-113
16720448-2	2006	The COX-2-mPGES-PGE2 system may induce differentiation of cancer cells and prevent metastasis, thus improving the survival rate.	Dinoprostone	16-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
16357062-0	2006	Heregulin-alpha and heregulin-beta expression is linked to a COX-2-PGE2 pathway in human gastric fibroblasts.	Dinoprostone	67-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-66
16755175-1	2006	OBJECTIVE: COX-2 activation may mediate capecitabine induced toxicities, eg, hand-foot syndrome (HFS) and colorectal cancer progression, both of which may be improved by concurrent celecoxib.	Capecitabine	40-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-16
16755175-1	2006	OBJECTIVE: COX-2 activation may mediate capecitabine induced toxicities, eg, hand-foot syndrome (HFS) and colorectal cancer progression, both of which may be improved by concurrent celecoxib.	Celecoxib	181-190	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-16
16357062-8	2006	Preincubation of the fibroblasts with celecoxib, a selective COX-2 inhibitor, suppressed CM-induced erbB3 phosphorylation.	Celecoxib	38-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-66
16357062-11	2006	IL-1beta-stimulated HRG expression and release were also inhibited by celecoxib, and exogenous PGE(2) restored this inhibitory effect, suggesting the activation of an IL-1beta-COX-2-PGE(2) pathway that culminates in the release of HRG from fibroblasts.	Celecoxib	70-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	176-181
16357062-11	2006	IL-1beta-stimulated HRG expression and release were also inhibited by celecoxib, and exogenous PGE(2) restored this inhibitory effect, suggesting the activation of an IL-1beta-COX-2-PGE(2) pathway that culminates in the release of HRG from fibroblasts.	Prostaglandins E	95-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	176-181
16357062-11	2006	IL-1beta-stimulated HRG expression and release were also inhibited by celecoxib, and exogenous PGE(2) restored this inhibitory effect, suggesting the activation of an IL-1beta-COX-2-PGE(2) pathway that culminates in the release of HRG from fibroblasts.	Prostaglandins E	182-185	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	176-181
16380459-2	2006	In these cells, immunoreactive COX-2 and vasodilatory prostaglandins were increased by a NO donor, S-nitros-N-acetylpenicillamine (SNAP; 2.5 +/- 0.3-fold control, n = 6, P &lt; 0.01).	S-nitro-N-acetylpenicillamine	99-129	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-36
16760523-1	2006	Tissue expression of cyclooxygenase (COX)2, an inducible enzyme synthesizing eicosanoids in inflammation, was studied in reversal reaction (RR) leprosy in comparison with nonreactionary leprosy.	Eicosanoids	77-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-42
16414978-4	2006	Herein, we tested the hypothesis that pneumococci induced COX-2-dependent PGE(2) production in pulmonary epithelial cells.	Dinoprostone	74-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
16414978-10	2006	PGE(2) release and COX-2 expression were reduced by p38 MAPK inhibitor SB-202190 but not by JNK inhibitor SP-600125.	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	71-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-24
16476920-0	2006	The COX-2 specific inhibitor Valdecoxib versus tramadol in acute ankle sprain: a multicenter randomized, controlled trial.	valdecoxib	29-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
16269423-6	2006	Concordant decreased expression was observed for ICAM-1, COX1, COX2, and the NF-kappaB complex after Lef-M+MTX treatment.	Methotrexate	107-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-67
16361272-2	2006	Although the mechanisms by which NSAIDs lower cancer risk remain unclear, NSAIDs reduce prostaglandin production by blocking prostaglandin-endoperoxide synthase 2 (PTGS2, commonly known as COX-2), an enzyme induced by proinflammatory stimuli that is often overexpressed in malignant tissue.	Prostaglandins	88-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	189-194
16787194-7	2006	COX-2 inhibitors, commonly referred to as coxibs, were developed to inhibit inflammatory prostanoids without interfering with production of COX-1 prostanoids.	Prostaglandins	89-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
16787194-8	2006	Concerns over cardiovascular safety, however, have evolved based on the concept of inhibition of COX-2-derived endothelial prostanoids without inhibition of platelet thromboxane A2, leading to increased cardiovascular risk.	Prostaglandins	123-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
16787194-12	2006	COX-2 expression increases in high renin states and in response to a high-sodium diet or water deprivation.	Sodium	74-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
16787194-16	2006	This review article discusses beneficial and deleterious effects associated with prostanoids produced by COX-1 and COX-2 in various organs and how blockade of these products translates into clinical medicine.	Prostaglandins	81-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-120
16458279-1	2006	BACKGROUND: Cyclooxygenase (COX)-2, a key regulatory enzyme in prostanoid synthesis, plays an important role in inflammatory processes.	Prostaglandins	63-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-34
16730488-0	2006	Efficacy of a selective COX-2 inhibitor for controlling irregular uterine bleeding in DMPA users.	Medroxyprogesterone Acetate	86-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
16846549-3	2006	FINDINGS: The members of the Consensus Report Group on Nimesulide (CRGN) recognised that nimesulide is an NSAID which exerts its analgesic, anti-inflammatory and antipyretic activities thanks to unique chemical and pharmacokinetic characteristics, and to a multifactorial mechanism of action, which goes beyond its preferential inhibitory activity on the COX-2 enzyme.	nimesulide	55-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	355-360
16846549-3	2006	FINDINGS: The members of the Consensus Report Group on Nimesulide (CRGN) recognised that nimesulide is an NSAID which exerts its analgesic, anti-inflammatory and antipyretic activities thanks to unique chemical and pharmacokinetic characteristics, and to a multifactorial mechanism of action, which goes beyond its preferential inhibitory activity on the COX-2 enzyme.	nimesulide	89-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	355-360
16460988-2	2006	In the early 1990s, it was discovered that enzymatic reactions producing prostaglandins were regulated by two cyclooxygenase enzymes, one producing prostaglandins constitutively in tissues like the stomach, prostaglandin endoperoxide H synthase-1 (PGHS-1 or COX-1), and another induced by mitogens or inflammatory mediators (PGHS-2 or COX-2).	Prostaglandins	73-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	335-340
16460988-2	2006	In the early 1990s, it was discovered that enzymatic reactions producing prostaglandins were regulated by two cyclooxygenase enzymes, one producing prostaglandins constitutively in tissues like the stomach, prostaglandin endoperoxide H synthase-1 (PGHS-1 or COX-1), and another induced by mitogens or inflammatory mediators (PGHS-2 or COX-2).	Prostaglandins	148-162	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	335-340
16460988-2	2006	In the early 1990s, it was discovered that enzymatic reactions producing prostaglandins were regulated by two cyclooxygenase enzymes, one producing prostaglandins constitutively in tissues like the stomach, prostaglandin endoperoxide H synthase-1 (PGHS-1 or COX-1), and another induced by mitogens or inflammatory mediators (PGHS-2 or COX-2).	Prostaglandins	73-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	335-340
16865586-10	2006	Moreover, the COX-2 mRNA expression and the grade of infiltrating inflammatory cells in the esophageal mucosa significantly correlated with the trypsin activity and bile acid concentrations in the esophagus.	Bile Acids and Salts	165-174	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
16741061-4	2006	In the present study, pretreatment of HEY and OVCA 433 ovarian carcinoma cell lines with green tea and EGCG inhibited ET-1/ET(A)R expression, ET(A)R-mediated COX-1/2 mRNA expression, and COX-2 promoter activity.	epigallocatechin gallate	103-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	187-192
16762637-2	2006	Cyclooxygenase (COX)-2, which is a key enzyme of prostaglandin (PG) biosynthesis, is overexpressed in around 75% of human carcinomas including those of the pancreas.	Prostaglandins	49-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-22
16685418-6	2006	Resveratrol also attenuated beta-amyloid-induced prostaglandin E2 (PGE2) release, which was associated with the inhibition of cyclooxygenase (COX)-2 expression.	Resveratrol	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-148
16685418-6	2006	Resveratrol also attenuated beta-amyloid-induced prostaglandin E2 (PGE2) release, which was associated with the inhibition of cyclooxygenase (COX)-2 expression.	Dinoprostone	67-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-148
16751012-1	2006	BACKGROUND: Levels of COX-2 and downstream products, such as prostaglandin (PG) E2, are increased in inflammatory settings after stimulation by IL-1beta, LPS, and other innate factors.	Dinoprostone	61-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-27
16751012-7	2006	RESULTS: IL-13 significantly inhibited the PGE2 synthetic pathways COX-2 and PGE synthase 1 while upregulating the PGE2 metabolizing enzyme 15-PG dehydrogenase.	Dinoprostone	43-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-72
16403505-0	2006	Removal of As(V) by Cu(II)-, Ni(II)-, or Co(II)-doped goethite samples.	asunaprevir	11-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-47
16403505-0	2006	Removal of As(V) by Cu(II)-, Ni(II)-, or Co(II)-doped goethite samples.	goethite	54-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-47
16403505-1	2006	The present study reports removal of As(V) by adsorption onto laboratory-prepared pure and Cu(II)-, Ni(II)-, and Co(II)-doped goethite samples.	Arsenic	37-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-119
16403505-1	2006	The present study reports removal of As(V) by adsorption onto laboratory-prepared pure and Cu(II)-, Ni(II)-, and Co(II)-doped goethite samples.	goethite	126-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-119
16778086-3	2006	Parthenolide, a nuclear factor-kappaB (NF-kappaB) inhibitor, and NS398, a cyclooxygenase (COX)-2 inhibitor, have been shown to individually suppress the growth of hepatocellular carcinoma cells in vitro.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	65-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-96
16546299-6	2006	We further demonstrate that protein kinase C (PKC) is involved in Abeta(25-35)-induced COX-2/PGE(2) synthesis.	UNII-042A8N37WH	66-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-92
16546299-7	2006	PKC-inhibitors prevent Abeta(25-35)-induced COX-2 and PGE(2) synthesis.	UNII-042A8N37WH	23-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-49
16546299-9	2006	Our data suggest that the PKC isoforms alpha and/or beta are most probably involved in Abeta(25-35)-induced expression of COX-2 in midbrain astrocytes.	UNII-042A8N37WH	87-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-127
16685393-2	2006	The IFN-alpha-induced COX-2 expression and STAT1 activation were markedly inhibited by the addition of curcumin to the IFN-alpha-pretreated cells.	Curcumin	103-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-27
16122789-7	2006	Treatment of cells with BAY 11-7082 at 50 microM significantly inhibited basal, LPS- and TNF-alpha-induced NF-kappaB and COX-2 expression, and IL-6 and PGF2alpha release.	3-(4-methylphenylsulfonyl)-2-propenenitrile	24-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-126
16183115-3	2006	mPGES-1 and COX-2 form an inducible pathway for PGE2 production in many cell systems.	Dinoprostone	48-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-17
16752024-10	2006	CONCLUSION: Celecoxib, a COX-2 selective inhibitor, is as effective as diclofenac SR in treating ankle sprains.	Celecoxib	12-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-30
16697099-13	2006	In addition, cantharidin also stimulated COX 2 over-expression and PGE(2) production in T 24 cells, in a dose-dependent manner.	Cantharidin	13-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-46
16697099-15	2006	Therefore, we suggest that cantharidin may induce cystitis through secondary necrosis and COX 2 over-expression.	Cantharidin	27-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-95
16719481-3	2006	The trend in the magnitude of the NTE behavior, with increasing atomic number (Z) of the M(II) ion, follows the order Mn(II) &gt; Fe(II) &gt; Co(II) &gt; Ni(II) &lt; Cu(II) &lt; Zn(II) &lt; Cd(II), which correlates with the trends for M(II) cation size, the lattice parameter, and structural flexibility as indicated by the temperature-dependent structural refinements and Raman spectroscopy.	Manganese(2+)	118-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	142-148
16719481-3	2006	The trend in the magnitude of the NTE behavior, with increasing atomic number (Z) of the M(II) ion, follows the order Mn(II) &gt; Fe(II) &gt; Co(II) &gt; Ni(II) &lt; Cu(II) &lt; Zn(II) &lt; Cd(II), which correlates with the trends for M(II) cation size, the lattice parameter, and structural flexibility as indicated by the temperature-dependent structural refinements and Raman spectroscopy.	Nickel(2+)	154-160	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	142-148
16719481-3	2006	The trend in the magnitude of the NTE behavior, with increasing atomic number (Z) of the M(II) ion, follows the order Mn(II) &gt; Fe(II) &gt; Co(II) &gt; Ni(II) &lt; Cu(II) &lt; Zn(II) &lt; Cd(II), which correlates with the trends for M(II) cation size, the lattice parameter, and structural flexibility as indicated by the temperature-dependent structural refinements and Raman spectroscopy.	cu(ii)	166-172	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	142-148
16719481-3	2006	The trend in the magnitude of the NTE behavior, with increasing atomic number (Z) of the M(II) ion, follows the order Mn(II) &gt; Fe(II) &gt; Co(II) &gt; Ni(II) &lt; Cu(II) &lt; Zn(II) &lt; Cd(II), which correlates with the trends for M(II) cation size, the lattice parameter, and structural flexibility as indicated by the temperature-dependent structural refinements and Raman spectroscopy.	Zinc	178-184	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	142-148
16719481-3	2006	The trend in the magnitude of the NTE behavior, with increasing atomic number (Z) of the M(II) ion, follows the order Mn(II) &gt; Fe(II) &gt; Co(II) &gt; Ni(II) &lt; Cu(II) &lt; Zn(II) &lt; Cd(II), which correlates with the trends for M(II) cation size, the lattice parameter, and structural flexibility as indicated by the temperature-dependent structural refinements and Raman spectroscopy.	cd(ii)	190-196	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	142-148
16711691-3	2006	The tridentate 4-terpyridone ligands coordinate the Co(II) ions in a mer fashion defining essentially tetragonally compressed [CoN6] octahedrons.	2,6-Bis(2-pyridyl)-4(1H)-pyridone	15-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-58
16711691-5	2006	The differences in the average Co-N(central) or Co-N(distal) distances observed for 1-7 reflect the different spin states of Co(II).	co-n	31-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-131
16711691-5	2006	The differences in the average Co-N(central) or Co-N(distal) distances observed for 1-7 reflect the different spin states of Co(II).	co-n	48-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-131
16681389-4	2006	Here we demonstrate that histone deacetylase 8 (HDAC8) is catalytically active with a number of divalent metal ions in a 1:1 stoichiometry with the following order of specific activity: Co(II) &gt; Fe(II) &gt; Zn(II) &gt; Ni(II).	Metals	105-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	186-192
16681389-4	2006	Here we demonstrate that histone deacetylase 8 (HDAC8) is catalytically active with a number of divalent metal ions in a 1:1 stoichiometry with the following order of specific activity: Co(II) &gt; Fe(II) &gt; Zn(II) &gt; Ni(II).	Zinc	210-216	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	186-192
16681389-4	2006	Here we demonstrate that histone deacetylase 8 (HDAC8) is catalytically active with a number of divalent metal ions in a 1:1 stoichiometry with the following order of specific activity: Co(II) &gt; Fe(II) &gt; Zn(II) &gt; Ni(II).	Nickel(2+)	222-228	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	186-192
16681389-5	2006	The identity of the catalytic metal ion influences both the affinity of the HDAC inhibitor suberoylanilide hydroxamic acid (SAHA) and the Michaelis constant, with Fe(II)- and Co(II)-HDAC8 having K(M) values that are over 5-fold lower than that of Zn(II)-HDAC8.	Metals	30-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	175-187
16681389-5	2006	The identity of the catalytic metal ion influences both the affinity of the HDAC inhibitor suberoylanilide hydroxamic acid (SAHA) and the Michaelis constant, with Fe(II)- and Co(II)-HDAC8 having K(M) values that are over 5-fold lower than that of Zn(II)-HDAC8.	Vorinostat	91-122	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	175-187
16681389-5	2006	The identity of the catalytic metal ion influences both the affinity of the HDAC inhibitor suberoylanilide hydroxamic acid (SAHA) and the Michaelis constant, with Fe(II)- and Co(II)-HDAC8 having K(M) values that are over 5-fold lower than that of Zn(II)-HDAC8.	Vorinostat	124-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	175-187
16376922-1	2006	We have investigated the electrocatalytic dehalogenation of beta-methylallyl chloride (beta-mAC), widely used in the polymer industry, using [Co(I)(bpy)3]+ (where bpy=2,2"-bipyridine) electrochemically generated in situ from [Co(II)(bpy)3]2+ at a glassy carbon electrode in the presence of three different cationic surfactants in aqueous solution.	3-chloro-2-methylprop-1-ene	60-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	226-231
16376922-1	2006	We have investigated the electrocatalytic dehalogenation of beta-methylallyl chloride (beta-mAC), widely used in the polymer industry, using [Co(I)(bpy)3]+ (where bpy=2,2"-bipyridine) electrochemically generated in situ from [Co(II)(bpy)3]2+ at a glassy carbon electrode in the presence of three different cationic surfactants in aqueous solution.	3-chloro-2-methylprop-1-ene	87-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	226-231
16376922-1	2006	We have investigated the electrocatalytic dehalogenation of beta-methylallyl chloride (beta-mAC), widely used in the polymer industry, using [Co(I)(bpy)3]+ (where bpy=2,2"-bipyridine) electrochemically generated in situ from [Co(II)(bpy)3]2+ at a glassy carbon electrode in the presence of three different cationic surfactants in aqueous solution.	NAD	142-147	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	226-231
16376922-3	2006	The [Co(II)(bpy)3]2+-cationic surfactant systems show excellent electrocatalytic activity toward dehalogenation of beta-mAC.	3-chloro-2-methylprop-1-ene	115-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	5-10
16619186-3	2006	Although molecular interactions between TNF-alpha and PGE2 are largely unexplored in human malaria, results presented here show that pfHz-induced suppression of PBMC COX-2 gene products induces overproduction of TNF-alpha.	Dinoprostone	54-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	166-171
16619186-3	2006	Although molecular interactions between TNF-alpha and PGE2 are largely unexplored in human malaria, results presented here show that pfHz-induced suppression of PBMC COX-2 gene products induces overproduction of TNF-alpha.	pfhz	133-137	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	166-171
16760523-5	2006	This is in keeping with experimental models relating VEGF to COX2 expression, with VEGF enhancing prostaglandin production through COX2 stimulation and prostaglandin synthase expression.	Prostaglandins	98-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-135
16633692-1	2006	In this paper, we investigated the reliability of a Car-Parrinello molecular dynamics (CPMD) approach to characterize the binding of Co(II) metal cation to peptide molecules containing cysteine.	Metals	140-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	133-139
16633692-4	2006	Benchmark calculations are performed on [Co(Cys-H)]+ and [Co(Glutathione-H)]+ complexes, since they are the main fragments of the Co(II)-Cys and Co(II)-glutathione systems found in gas phase electrospray ionisation mass spectrometry (ESI-MS) experiments done in our laboratory.	Glutathione	152-163	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-151
16633692-1	2006	In this paper, we investigated the reliability of a Car-Parrinello molecular dynamics (CPMD) approach to characterize the binding of Co(II) metal cation to peptide molecules containing cysteine.	Cysteine	185-193	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	133-139
16633692-6	2006	In particular, we investigated the dissociation path of one water molecule from the first hydration shell of Co(II) with CPMD.	Water	60-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-115
16633692-4	2006	Benchmark calculations are performed on [Co(Cys-H)]+ and [Co(Glutathione-H)]+ complexes, since they are the main fragments of the Co(II)-Cys and Co(II)-glutathione systems found in gas phase electrospray ionisation mass spectrometry (ESI-MS) experiments done in our laboratory.	co(cys-h)	41-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	130-136
16633692-7	2006	Overall, our molecular dynamics simulations shed some light on the nature of the Co(II) interaction and reactivity in Co(II)-phytochelatin building block systems related to the biological and environmental activity of the metal, either in the gas or liquid phase.	Metals	222-227	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-87
16633692-7	2006	Overall, our molecular dynamics simulations shed some light on the nature of the Co(II) interaction and reactivity in Co(II)-phytochelatin building block systems related to the biological and environmental activity of the metal, either in the gas or liquid phase.	Metals	222-227	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-124
16633692-4	2006	Benchmark calculations are performed on [Co(Cys-H)]+ and [Co(Glutathione-H)]+ complexes, since they are the main fragments of the Co(II)-Cys and Co(II)-glutathione systems found in gas phase electrospray ionisation mass spectrometry (ESI-MS) experiments done in our laboratory.	co(cys-h)	41-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-151
16633692-4	2006	Benchmark calculations are performed on [Co(Cys-H)]+ and [Co(Glutathione-H)]+ complexes, since they are the main fragments of the Co(II)-Cys and Co(II)-glutathione systems found in gas phase electrospray ionisation mass spectrometry (ESI-MS) experiments done in our laboratory.	co(glutathione	58-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	130-136
16633692-4	2006	Benchmark calculations are performed on [Co(Cys-H)]+ and [Co(Glutathione-H)]+ complexes, since they are the main fragments of the Co(II)-Cys and Co(II)-glutathione systems found in gas phase electrospray ionisation mass spectrometry (ESI-MS) experiments done in our laboratory.	co(glutathione	58-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-151
16633692-4	2006	Benchmark calculations are performed on [Co(Cys-H)]+ and [Co(Glutathione-H)]+ complexes, since they are the main fragments of the Co(II)-Cys and Co(II)-glutathione systems found in gas phase electrospray ionisation mass spectrometry (ESI-MS) experiments done in our laboratory.	Cysteine	44-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	130-136
16633692-4	2006	Benchmark calculations are performed on [Co(Cys-H)]+ and [Co(Glutathione-H)]+ complexes, since they are the main fragments of the Co(II)-Cys and Co(II)-glutathione systems found in gas phase electrospray ionisation mass spectrometry (ESI-MS) experiments done in our laboratory.	Cysteine	44-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-151
16712448-1	2006	The biological role of COX-2, the inducible form of cyclooxygenase, is to convert arachidonic acid into prostaglandins (PGs) and thromboxanes (TXs).	Arachidonic Acid	82-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-28
16712448-1	2006	The biological role of COX-2, the inducible form of cyclooxygenase, is to convert arachidonic acid into prostaglandins (PGs) and thromboxanes (TXs).	Prostaglandins	104-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-28
16712448-1	2006	The biological role of COX-2, the inducible form of cyclooxygenase, is to convert arachidonic acid into prostaglandins (PGs) and thromboxanes (TXs).	Prostaglandins	120-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-28
16712448-1	2006	The biological role of COX-2, the inducible form of cyclooxygenase, is to convert arachidonic acid into prostaglandins (PGs) and thromboxanes (TXs).	Thromboxanes	129-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-28
16712448-1	2006	The biological role of COX-2, the inducible form of cyclooxygenase, is to convert arachidonic acid into prostaglandins (PGs) and thromboxanes (TXs).	Thromboxanes	143-146	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-28
16712448-2	2006	Overexpressed in many tumors, COX-2 plays a crucial role in cancer through synthesis of PGs which stimulate PGs receptors with subsequent enhancement of cellular proliferation, promotion of angiogenesis, inhibition of apoptosis, stimulation of invasion/motility, and suppression of immune responses.	Prostaglandins	88-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-35
16827136-0	2006	COX-2 inhibitors celecoxib and rofecoxib prevent oxidative DNA fragmentation.	Celecoxib	17-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
16712448-3	2006	Depending on the tissue specificity and the cell type, several signaling pathways (Kinases, Rho, cGMP and Wnt), and transcription factors such as AP1, NFAT or NF-kappaB, are involved in COX-2 expression.	Cyclic GMP	97-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	186-191
16827136-0	2006	COX-2 inhibitors celecoxib and rofecoxib prevent oxidative DNA fragmentation.	rofecoxib	31-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
16712450-7	2006	Studies have shown higher levels of COX-2 isoform in breast cancer tissue when compared to normal breast tissue, and this is accompanied by high concentrations of prostaglandin E(2) (PGE(2)).	Prostaglandins E	163-179	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-41
16712450-7	2006	Studies have shown higher levels of COX-2 isoform in breast cancer tissue when compared to normal breast tissue, and this is accompanied by high concentrations of prostaglandin E(2) (PGE(2)).	Prostaglandins E	183-186	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-41
16712450-12	2006	High levels of COX-2 expression result in higher levels of prostaglandin E(2) (PGE(2)), which in turn increases CYP19 expression through increases in intracellular cyclic AMP levels and activation of promoter II.	Dinoprostone	59-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-20
16712450-12	2006	High levels of COX-2 expression result in higher levels of prostaglandin E(2) (PGE(2)), which in turn increases CYP19 expression through increases in intracellular cyclic AMP levels and activation of promoter II.	Prostaglandins E	79-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-20
16712450-12	2006	High levels of COX-2 expression result in higher levels of prostaglandin E(2) (PGE(2)), which in turn increases CYP19 expression through increases in intracellular cyclic AMP levels and activation of promoter II.	Cyclic AMP	164-174	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-20
16712451-3	2006	The present review focuses on the state of the art in cancer research developed with COX-2 preferential/selective inhibitors belonging to the family of N-arylmethanesulfonamides, in particular nimesulide and NS-398.	n-arylmethanesulfonamides	152-177	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-90
16712451-3	2006	The present review focuses on the state of the art in cancer research developed with COX-2 preferential/selective inhibitors belonging to the family of N-arylmethanesulfonamides, in particular nimesulide and NS-398.	nimesulide	193-203	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-90
16712451-3	2006	The present review focuses on the state of the art in cancer research developed with COX-2 preferential/selective inhibitors belonging to the family of N-arylmethanesulfonamides, in particular nimesulide and NS-398.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	208-214	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-90
16520738-3	2006	Buddlejasaponin IV (2.5-10 microM) reduced lipopolysaccaride (LPS (1 microg ml(-1)))-induced levels of iNOS and COX-2 at the protein levels, and iNOS, COX-2, TNF-alpha, interleukin (IL)-1beta and IL-6 mRNA expression in RAW 264.7 macrophages in a concentration-dependent manner, as determined by Western blotting and RT-PCR, respectively.	lipopolysaccaride	43-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-117
16520738-4	2006	Buddlejasaponin IV inhibited the LPS-induced activation of nuclear factor-kappaB (NF-kappaB), a transcription factor necessary for proinflammatory mediators, iNOS, COX-2, TNF-alpha, IL-1beta and IL-6 expression.	buddlejasaponin	0-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	164-169
16581222-9	2006	Therefore, the results of the present study suggest that NO may up-regulate the production of PGE2 by augmenting the COX-2 pathway initiated by the binding between HOS cell-derived integrin alphaV and HA surface.	Dinoprostone	94-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-122
16678543-2	2006	METHODS: To better understand the molecular responses to COX inhibition, we analyzed the gene expression level of the genes encoding enzymes related to prostaglandin production including the COX-1 gene (PTGS1) and the COX-2 gene (PTGS2), as well as their genetic polymorphisms, and the analgesic response to COX inhibitory drugs such as ibuprofen or rofecoxib or to placebo after minor surgery.	Prostaglandins	152-165	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	218-223
16579869-3	2006	With regard to the metabolism of arachidonic acid (AA) in NSAID-intolerant asthmatic patients, the following changes have been observed: 1) A low production of prostaglandin E2, seemingly due to deficient Cox-2 regulation; 2) an increased expression of leukotriene-C4 synthase; and 3) a reduced production of metabolites (lipoxins) released through the transcellular metabolism of AA.	Arachidonic Acid	33-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	205-210
16579869-3	2006	With regard to the metabolism of arachidonic acid (AA) in NSAID-intolerant asthmatic patients, the following changes have been observed: 1) A low production of prostaglandin E2, seemingly due to deficient Cox-2 regulation; 2) an increased expression of leukotriene-C4 synthase; and 3) a reduced production of metabolites (lipoxins) released through the transcellular metabolism of AA.	Dinoprostone	160-176	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	205-210
16634575-3	2006	This is exemplified by Co(II) dimers with Co(II)-mu-Cl-Co(II) motifs, in which the chloro ligand is involved in four intramolecular hydrogen bonds.	Sodium Hypochlorite	83-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-28
18690928-10	2006	Recent signals include amnesia and QTc prolongation with sibutramine; pain activation with sumatriptan; epistaxis with risperidone; psychiatric and visual disturbances with the COX-2 inhibitors celecoxib and rofecoxib and psoriasis with rofecoxib.	Celecoxib	194-203	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	177-182
18690928-10	2006	Recent signals include amnesia and QTc prolongation with sibutramine; pain activation with sumatriptan; epistaxis with risperidone; psychiatric and visual disturbances with the COX-2 inhibitors celecoxib and rofecoxib and psoriasis with rofecoxib.	rofecoxib	208-217	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	177-182
18690928-10	2006	Recent signals include amnesia and QTc prolongation with sibutramine; pain activation with sumatriptan; epistaxis with risperidone; psychiatric and visual disturbances with the COX-2 inhibitors celecoxib and rofecoxib and psoriasis with rofecoxib.	rofecoxib	237-246	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	177-182
16634575-3	2006	This is exemplified by Co(II) dimers with Co(II)-mu-Cl-Co(II) motifs, in which the chloro ligand is involved in four intramolecular hydrogen bonds.	Sodium Hypochlorite	83-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47
16634575-3	2006	This is exemplified by Co(II) dimers with Co(II)-mu-Cl-Co(II) motifs, in which the chloro ligand is involved in four intramolecular hydrogen bonds.	Sodium Hypochlorite	83-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47
16634575-3	2006	This is exemplified by Co(II) dimers with Co(II)-mu-Cl-Co(II) motifs, in which the chloro ligand is involved in four intramolecular hydrogen bonds.	Hydrogen	132-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-28
16634575-3	2006	This is exemplified by Co(II) dimers with Co(II)-mu-Cl-Co(II) motifs, in which the chloro ligand is involved in four intramolecular hydrogen bonds.	Hydrogen	132-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47
16634575-3	2006	This is exemplified by Co(II) dimers with Co(II)-mu-Cl-Co(II) motifs, in which the chloro ligand is involved in four intramolecular hydrogen bonds.	Hydrogen	132-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47
16634581-6	2006	In the dinuclear heterobimetallic derivatives one of the metal ions [Cu(II) or Co(II)] is hexacoordinate and is bound by the cyclophosphazene in a eta5-gem-N5 mode.	Metals	25-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-85
16634581-6	2006	In the dinuclear heterobimetallic derivatives one of the metal ions [Cu(II) or Co(II)] is hexacoordinate and is bound by the cyclophosphazene in a eta5-gem-N5 mode.	cu(ii)	69-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-85
16634581-6	2006	In the dinuclear heterobimetallic derivatives one of the metal ions [Cu(II) or Co(II)] is hexacoordinate and is bound by the cyclophosphazene in a eta5-gem-N5 mode.	cyclophosphazene	125-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-85
16634581-6	2006	In the dinuclear heterobimetallic derivatives one of the metal ions [Cu(II) or Co(II)] is hexacoordinate and is bound by the cyclophosphazene in a eta5-gem-N5 mode.	8-dehydroxythienamycin	156-158	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-85
16557412-9	2006	Combination therapy with salicylic acid seems to abolish the protective effect of COX-2-inhibitors in the GI-tract.	Salicylic Acid	25-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
16634581-7	2006	The other metal ion in these heterobimetallic derivatives [Co(II) or Zn(II)] is tetracoordinate and is bound in an eta(1)-N(1) fashion.	Metals	10-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
16634581-7	2006	The other metal ion in these heterobimetallic derivatives [Co(II) or Zn(II)] is tetracoordinate and is bound in an eta(1)-N(1) fashion.	Zinc	69-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
16634581-13	2006	The coordination environment around the bridging Co(II) ion contains four oxygen (two P-O units, one chelating nitrate) and two nitrogen atoms (pyridyloxy nitrogens).	Oxygen	74-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-55
16634581-13	2006	The coordination environment around the bridging Co(II) ion contains four oxygen (two P-O units, one chelating nitrate) and two nitrogen atoms (pyridyloxy nitrogens).	Nitrates	111-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-55
16634581-13	2006	The coordination environment around the bridging Co(II) ion contains four oxygen (two P-O units, one chelating nitrate) and two nitrogen atoms (pyridyloxy nitrogens).	Nitrogen	128-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-55
16596229-10	2006	COX-2 was not detected in MCF-7 cells, but its expression in RMTCs was inhibited by SA treatment, which also significantly reduced BCC growth, but failed to cause cell death by necrosis or apoptosis.	Salicylates	84-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
16634581-13	2006	The coordination environment around the bridging Co(II) ion contains four oxygen (two P-O units, one chelating nitrate) and two nitrogen atoms (pyridyloxy nitrogens).	Nitrogen	155-164	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-55
16526022-12	2006	Curcumin also down regulated the expression of COX-2, a gene regulated by NFkappaB.	Curcumin	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
16624414-1	2006	XANES spectroscopy has been used to investigate whether it is possible to determine the oxidation state and coordination environment of Co complexes following treatment of cancer cells with Co(III) or Co(II) complexes.	xanes	0-5	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	201-207
16624414-1	2006	XANES spectroscopy has been used to investigate whether it is possible to determine the oxidation state and coordination environment of Co complexes following treatment of cancer cells with Co(III) or Co(II) complexes.	Co complexes	136-148	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	201-207
16508969-4	2006	EGCG significantly inhibited constitutive COX-2 mRNA and protein overexpression.	epigallocatechin gallate	0-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47
16508969-5	2006	The inhibitory effects of EGCG on signaling pathways controlling COX-2 expression were examined.	epigallocatechin gallate	26-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-70
16508969-7	2006	The effect of EGCG on COX-2 expression resulted in decreased COX-2 promoter activity via inhibition of nuclear factor kappaB (NF-kappaB) activation.	epigallocatechin gallate	14-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-27
16508969-7	2006	The effect of EGCG on COX-2 expression resulted in decreased COX-2 promoter activity via inhibition of nuclear factor kappaB (NF-kappaB) activation.	epigallocatechin gallate	14-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-66
16556676-8	2006	The selective COX-2 inhibitor NS-398 completely inhibits the increased production of PGs induced by IL-1beta in both cell types, whereas dexamethasone (DEX) exerts a stronger inhibition in HIESC than in HIEEC.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	30-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
16556676-8	2006	The selective COX-2 inhibitor NS-398 completely inhibits the increased production of PGs induced by IL-1beta in both cell types, whereas dexamethasone (DEX) exerts a stronger inhibition in HIESC than in HIEEC.	Prostaglandins	85-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
16596191-5	2006	Furthermore, curcumin decreased the levels of COX-2 mRNA and protein expression without significant changes in the levels of COX-1, which correlated with a decrease in prostaglandin E2 (PGE2) synthesis.	Curcumin	13-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
16618538-3	2006	NS398, and ASA, can inhibit PGE2 generation via COX-2 inhibition.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	0-5	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-53
16618538-3	2006	NS398, and ASA, can inhibit PGE2 generation via COX-2 inhibition.	Aspirin	11-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-53
16618538-3	2006	NS398, and ASA, can inhibit PGE2 generation via COX-2 inhibition.	Dinoprostone	28-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-53
16672767-6	2006	In senescent cells, after LPA treatment, the expression of c-fos and COX-2 decreased initially, followed by an increase.	lysophosphatidic acid	26-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-74
16618816-2	2006	Whether the newer second-generation COX-2 inhibitors (etoricoxib, valdecoxib) also increase the cardiovascular risk is unknown.	valdecoxib	66-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-41
16620085-1	2006	A three-dimensional magnetic material [{CoII(pyrimidine)(H2O)}2{CoII(H2O)2}{WV(CN)8}2](pyrimidine)2.	2](pyrimidine)	84-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-44
16620085-1	2006	A three-dimensional magnetic material [{CoII(pyrimidine)(H2O)}2{CoII(H2O)2}{WV(CN)8}2](pyrimidine)2.	2](pyrimidine)	84-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-68
16582994-0	2006	A new Co(II) coordination solid with mixed oxygen, carboxylate, pyridine and thiolate donors exhibiting canted antiferromagnetism with T(C) approximately 68 K. Reaction of Co(II) chloride with the sodium salt of 2-mercaptonicotinic acid in water at 200 degrees C results in the formation of Co4(2-mna)4(H2O), which orders as a canted antiferromagnet at 68 K.	Oxygen	43-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	6-12
16582994-0	2006	A new Co(II) coordination solid with mixed oxygen, carboxylate, pyridine and thiolate donors exhibiting canted antiferromagnetism with T(C) approximately 68 K. Reaction of Co(II) chloride with the sodium salt of 2-mercaptonicotinic acid in water at 200 degrees C results in the formation of Co4(2-mna)4(H2O), which orders as a canted antiferromagnet at 68 K.	Oxygen	43-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	6-11
16582994-0	2006	A new Co(II) coordination solid with mixed oxygen, carboxylate, pyridine and thiolate donors exhibiting canted antiferromagnetism with T(C) approximately 68 K. Reaction of Co(II) chloride with the sodium salt of 2-mercaptonicotinic acid in water at 200 degrees C results in the formation of Co4(2-mna)4(H2O), which orders as a canted antiferromagnet at 68 K.	carboxylate	51-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	6-12
16582994-0	2006	A new Co(II) coordination solid with mixed oxygen, carboxylate, pyridine and thiolate donors exhibiting canted antiferromagnetism with T(C) approximately 68 K. Reaction of Co(II) chloride with the sodium salt of 2-mercaptonicotinic acid in water at 200 degrees C results in the formation of Co4(2-mna)4(H2O), which orders as a canted antiferromagnet at 68 K.	carboxylate	51-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	6-11
16582994-0	2006	A new Co(II) coordination solid with mixed oxygen, carboxylate, pyridine and thiolate donors exhibiting canted antiferromagnetism with T(C) approximately 68 K. Reaction of Co(II) chloride with the sodium salt of 2-mercaptonicotinic acid in water at 200 degrees C results in the formation of Co4(2-mna)4(H2O), which orders as a canted antiferromagnet at 68 K.	pyridine	64-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	6-12
16582994-0	2006	A new Co(II) coordination solid with mixed oxygen, carboxylate, pyridine and thiolate donors exhibiting canted antiferromagnetism with T(C) approximately 68 K. Reaction of Co(II) chloride with the sodium salt of 2-mercaptonicotinic acid in water at 200 degrees C results in the formation of Co4(2-mna)4(H2O), which orders as a canted antiferromagnet at 68 K.	pyridine	64-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	6-11
16582994-0	2006	A new Co(II) coordination solid with mixed oxygen, carboxylate, pyridine and thiolate donors exhibiting canted antiferromagnetism with T(C) approximately 68 K. Reaction of Co(II) chloride with the sodium salt of 2-mercaptonicotinic acid in water at 200 degrees C results in the formation of Co4(2-mna)4(H2O), which orders as a canted antiferromagnet at 68 K.	thiolate	77-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	6-12
16582994-0	2006	A new Co(II) coordination solid with mixed oxygen, carboxylate, pyridine and thiolate donors exhibiting canted antiferromagnetism with T(C) approximately 68 K. Reaction of Co(II) chloride with the sodium salt of 2-mercaptonicotinic acid in water at 200 degrees C results in the formation of Co4(2-mna)4(H2O), which orders as a canted antiferromagnet at 68 K.	thiolate	77-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	6-11
16582994-0	2006	A new Co(II) coordination solid with mixed oxygen, carboxylate, pyridine and thiolate donors exhibiting canted antiferromagnetism with T(C) approximately 68 K. Reaction of Co(II) chloride with the sodium salt of 2-mercaptonicotinic acid in water at 200 degrees C results in the formation of Co4(2-mna)4(H2O), which orders as a canted antiferromagnet at 68 K.	Technetium	135-139	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	6-12
16582994-0	2006	A new Co(II) coordination solid with mixed oxygen, carboxylate, pyridine and thiolate donors exhibiting canted antiferromagnetism with T(C) approximately 68 K. Reaction of Co(II) chloride with the sodium salt of 2-mercaptonicotinic acid in water at 200 degrees C results in the formation of Co4(2-mna)4(H2O), which orders as a canted antiferromagnet at 68 K.	Technetium	135-139	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	6-11
16582994-0	2006	A new Co(II) coordination solid with mixed oxygen, carboxylate, pyridine and thiolate donors exhibiting canted antiferromagnetism with T(C) approximately 68 K. Reaction of Co(II) chloride with the sodium salt of 2-mercaptonicotinic acid in water at 200 degrees C results in the formation of Co4(2-mna)4(H2O), which orders as a canted antiferromagnet at 68 K.	sodium salt	197-208	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	6-12
16582994-0	2006	A new Co(II) coordination solid with mixed oxygen, carboxylate, pyridine and thiolate donors exhibiting canted antiferromagnetism with T(C) approximately 68 K. Reaction of Co(II) chloride with the sodium salt of 2-mercaptonicotinic acid in water at 200 degrees C results in the formation of Co4(2-mna)4(H2O), which orders as a canted antiferromagnet at 68 K.	sodium salt	197-208	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	6-11
16582994-0	2006	A new Co(II) coordination solid with mixed oxygen, carboxylate, pyridine and thiolate donors exhibiting canted antiferromagnetism with T(C) approximately 68 K. Reaction of Co(II) chloride with the sodium salt of 2-mercaptonicotinic acid in water at 200 degrees C results in the formation of Co4(2-mna)4(H2O), which orders as a canted antiferromagnet at 68 K.	2-mercaptonicotinic acid	212-236	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	6-12
16582994-0	2006	A new Co(II) coordination solid with mixed oxygen, carboxylate, pyridine and thiolate donors exhibiting canted antiferromagnetism with T(C) approximately 68 K. Reaction of Co(II) chloride with the sodium salt of 2-mercaptonicotinic acid in water at 200 degrees C results in the formation of Co4(2-mna)4(H2O), which orders as a canted antiferromagnet at 68 K.	2-mercaptonicotinic acid	212-236	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	6-11
16582994-0	2006	A new Co(II) coordination solid with mixed oxygen, carboxylate, pyridine and thiolate donors exhibiting canted antiferromagnetism with T(C) approximately 68 K. Reaction of Co(II) chloride with the sodium salt of 2-mercaptonicotinic acid in water at 200 degrees C results in the formation of Co4(2-mna)4(H2O), which orders as a canted antiferromagnet at 68 K.	co4(2-mna)4	291-302	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	6-12
16582994-0	2006	A new Co(II) coordination solid with mixed oxygen, carboxylate, pyridine and thiolate donors exhibiting canted antiferromagnetism with T(C) approximately 68 K. Reaction of Co(II) chloride with the sodium salt of 2-mercaptonicotinic acid in water at 200 degrees C results in the formation of Co4(2-mna)4(H2O), which orders as a canted antiferromagnet at 68 K.	co4(2-mna)4	291-302	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	6-11
16582994-0	2006	A new Co(II) coordination solid with mixed oxygen, carboxylate, pyridine and thiolate donors exhibiting canted antiferromagnetism with T(C) approximately 68 K. Reaction of Co(II) chloride with the sodium salt of 2-mercaptonicotinic acid in water at 200 degrees C results in the formation of Co4(2-mna)4(H2O), which orders as a canted antiferromagnet at 68 K.	Water	303-306	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	6-12
16582994-0	2006	A new Co(II) coordination solid with mixed oxygen, carboxylate, pyridine and thiolate donors exhibiting canted antiferromagnetism with T(C) approximately 68 K. Reaction of Co(II) chloride with the sodium salt of 2-mercaptonicotinic acid in water at 200 degrees C results in the formation of Co4(2-mna)4(H2O), which orders as a canted antiferromagnet at 68 K.	Water	303-306	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	6-11
16585977-7	2006	This suggests that the Co-tpa carrier system would provide a suitably inert framework to deliver the drugs to target sites intact yet would release the ligands upon reduction to the more labile Co(II) oxidation state.	co-tpa	23-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	194-199
16602786-1	2006	The reaction of M(S2O6) (M = Cu(II), Ni(II), and Co(II)) with 4,4"-bipyridine-N,N"-dioxide (bpdo) results in the formation of novel 3D, 2D, and mononuclear complexes.	s2o6	18-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-55
16602786-1	2006	The reaction of M(S2O6) (M = Cu(II), Ni(II), and Co(II)) with 4,4"-bipyridine-N,N"-dioxide (bpdo) results in the formation of novel 3D, 2D, and mononuclear complexes.	cu(ii)	29-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-55
16602786-1	2006	The reaction of M(S2O6) (M = Cu(II), Ni(II), and Co(II)) with 4,4"-bipyridine-N,N"-dioxide (bpdo) results in the formation of novel 3D, 2D, and mononuclear complexes.	2,2'-bipyridine-N, N'-dioxide	62-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-55
16602786-1	2006	The reaction of M(S2O6) (M = Cu(II), Ni(II), and Co(II)) with 4,4"-bipyridine-N,N"-dioxide (bpdo) results in the formation of novel 3D, 2D, and mononuclear complexes.	2,2'-bipyridine-N, N'-dioxide	92-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-55
16602786-3	2006	With Co(II) and Ni(II), 3-D complexes, {[M(bpdo)3](S2O6)(C2H5OH)7}n [M = Co(II) (2), Ni(II) (3)], were obtained.	[m(bpdo)3](s2o6)(c2h5oh)7	40-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	5-11
16602786-3	2006	With Co(II) and Ni(II), 3-D complexes, {[M(bpdo)3](S2O6)(C2H5OH)7}n [M = Co(II) (2), Ni(II) (3)], were obtained.	[m(bpdo)3](s2o6)(c2h5oh)7	40-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-79
16602786-5	2006	The same reaction in aqueous solution with a metal/ligand ratio of 1:1 results in the formation of mononuclear complexes, {[M(bpdo)(H2O)5](SO4)(H2O)2} [M = Co(II) (4), Ni(II) (5)], accompanied by the decomposition of the dithionate anions S2O6(2-) to sulfate anions SO4(2-).	Metals	45-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	156-162
16602786-5	2006	The same reaction in aqueous solution with a metal/ligand ratio of 1:1 results in the formation of mononuclear complexes, {[M(bpdo)(H2O)5](SO4)(H2O)2} [M = Co(II) (4), Ni(II) (5)], accompanied by the decomposition of the dithionate anions S2O6(2-) to sulfate anions SO4(2-).	[m(bpdo)(h2o)5](so4)(h2o)2	123-149	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	156-162
16602786-5	2006	The same reaction in aqueous solution with a metal/ligand ratio of 1:1 results in the formation of mononuclear complexes, {[M(bpdo)(H2O)5](SO4)(H2O)2} [M = Co(II) (4), Ni(II) (5)], accompanied by the decomposition of the dithionate anions S2O6(2-) to sulfate anions SO4(2-).	sulfuric acid	139-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	156-162
16585602-3	2006	PGE2 biosynthesis is controlled by cyclooxygenase-1 (COX-1) and COX-2, whose induction involves the STATs.	Dinoprostone	0-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-69
16585602-5	2006	SP exposure time and dose dependently induced an early (1-min) phosphorylation of JAK2, STAT3, and STAT5, followed by COX-2 expression and PGE2 production by 2 h. Pharmacologic experiments showed that PGE2 production is dependent on newly synthesized COX-2, but COX-1 protein.	Dinoprostone	201-205	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-123
16585602-5	2006	SP exposure time and dose dependently induced an early (1-min) phosphorylation of JAK2, STAT3, and STAT5, followed by COX-2 expression and PGE2 production by 2 h. Pharmacologic experiments showed that PGE2 production is dependent on newly synthesized COX-2, but COX-1 protein.	Dinoprostone	201-205	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	251-256
16709027-1	2006	Celecoxib (Celebrex) appears to be unique among the class of selective COX-2 inhibitors (coxibs), because this particular compound exerts a second function that is independent of its celebrated ability to inhibit COX-2.	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-76
16598848-0	2006	Different COX-independent effects of the COX-2 inhibitors etoricoxib and lumiracoxib.	Etoricoxib	58-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-46
16598848-0	2006	Different COX-independent effects of the COX-2 inhibitors etoricoxib and lumiracoxib.	lumiracoxib	73-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-46
16598848-1	2006	Etoricoxib and lumiracoxib are both highly selective COX-2 inhibitors.	Etoricoxib	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-58
16598848-1	2006	Etoricoxib and lumiracoxib are both highly selective COX-2 inhibitors.	lumiracoxib	15-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-58
16709027-1	2006	Celecoxib (Celebrex) appears to be unique among the class of selective COX-2 inhibitors (coxibs), because this particular compound exerts a second function that is independent of its celebrated ability to inhibit COX-2.	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	213-218
16709027-1	2006	Celecoxib (Celebrex) appears to be unique among the class of selective COX-2 inhibitors (coxibs), because this particular compound exerts a second function that is independent of its celebrated ability to inhibit COX-2.	Celecoxib	11-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-76
16709027-1	2006	Celecoxib (Celebrex) appears to be unique among the class of selective COX-2 inhibitors (coxibs), because this particular compound exerts a second function that is independent of its celebrated ability to inhibit COX-2.	Celecoxib	11-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	213-218
16709027-5	2006	One derivative, 2,5-dimethyl-celecoxib (DMC), which retains the antiproliferative and apoptosis-inducing function, but completely lacks the COX-2 inhibitory activity, is able to mimic faithfully all of the numerous antitumor effects of celecoxib that have been investigated so far, including reduction of neovascularization and inhibition of experimental tumor growth in various in vivo tumor models.	2,5-dimethylcelecoxib	16-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-145
16709027-5	2006	One derivative, 2,5-dimethyl-celecoxib (DMC), which retains the antiproliferative and apoptosis-inducing function, but completely lacks the COX-2 inhibitory activity, is able to mimic faithfully all of the numerous antitumor effects of celecoxib that have been investigated so far, including reduction of neovascularization and inhibition of experimental tumor growth in various in vivo tumor models.	2,5-dimethylcelecoxib	40-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-145
16709027-5	2006	One derivative, 2,5-dimethyl-celecoxib (DMC), which retains the antiproliferative and apoptosis-inducing function, but completely lacks the COX-2 inhibitory activity, is able to mimic faithfully all of the numerous antitumor effects of celecoxib that have been investigated so far, including reduction of neovascularization and inhibition of experimental tumor growth in various in vivo tumor models.	Celecoxib	29-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-145
16709027-7	2006	Because DMC is not a coxib yet potently maintains celecoxib"s antitumor potential, one may be inclined to speculate that this novel compound could potentially be advantageous in the management of COX-2-independent cancers.	2,5-dimethylcelecoxib	8-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	196-201
16552144-6	2006	In contrast, the Co(II)-form selective inhibitor (4) recruits an unexpected third metal ion, forming a trimetallic enzyme-metal-inhibitor complex.	Metals	82-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-23
16568183-0	2006	Preparation and characterization of Cr(III), Mn(II), Fe(II), Co(II) and Ni(II) complexes of a hexaazadithiophenolate macrocycle.	hexaazadithiophenolate	94-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-67
16568183-1	2006	The ligating properties of the 24-membered macrocyclic dinucleating hexaazadithiophenolate ligand (L(Me))2- towards the transition metal ions Cr(II), Mn(II), Fe(II), Co(II), Ni(II) and Zn(II) have been examined.	hexaazadithiophenolate	68-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	166-172
16568183-1	2006	The ligating properties of the 24-membered macrocyclic dinucleating hexaazadithiophenolate ligand (L(Me))2- towards the transition metal ions Cr(II), Mn(II), Fe(II), Co(II), Ni(II) and Zn(II) have been examined.	(l(me))2	98-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	166-172
16568183-1	2006	The ligating properties of the 24-membered macrocyclic dinucleating hexaazadithiophenolate ligand (L(Me))2- towards the transition metal ions Cr(II), Mn(II), Fe(II), Co(II), Ni(II) and Zn(II) have been examined.	Metals	131-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	166-172
16568183-2	2006	It is demonstrated that this ligand forms an isostructural series of bioctahedral [(L(Me))M(II)2(OAc)]+ complexes with Mn(II) (2), Fe(II) (3), Co(II) (4), Ni(II) (5) and Zn(II) (6).	(ii)2(oac)	91-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	143-149
16552144-6	2006	In contrast, the Co(II)-form selective inhibitor (4) recruits an unexpected third metal ion, forming a trimetallic enzyme-metal-inhibitor complex.	Metals	106-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-23
16579630-4	2006	The MCO reactions with Mn(II), Fe(II), Co(II), and Ni(II) occur to lesser extents than with Cu(II), but oxidation is still extensive enough to allow easy identification of the metal-bound residues.	mco	4-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-44
16494585-0	2006	Prevention of ulcers by esomeprazole in at-risk patients using non-selective NSAIDs and COX-2 inhibitors.	Esomeprazole	24-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-93
16494585-11	2006	CONCLUSIONS: For at-risk patients, esomeprazole was effective in preventing ulcers in long-term users of NSAIDs, including COX-2 inhibitors.	Esomeprazole	35-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-128
16579630-4	2006	The MCO reactions with Mn(II), Fe(II), Co(II), and Ni(II) occur to lesser extents than with Cu(II), but oxidation is still extensive enough to allow easy identification of the metal-bound residues.	Metals	176-181	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-44
16489533-5	2006	RESULTS: We observed a non-statistically significant inverse association between any Ala COX-2 genotype and risk of colon cancer (OR = 0.62, 95% CI: 0.33, 1.16) among African Americans.	Alanine	85-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-94
16831949-14	2006	Furthermore, our data support the notion that COX-2-dependent PGE2 produced at the early stage of bone healing is prerequisite for efficient skeletal repair.	Dinoprostone	62-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
16675300-6	2006	The delayed synthesis of PGE2 and PGF2alpha following the stimulation for 24 with a mixture of PMA and calcium ionophore A23187 was the highest in preadipocytes, reflecting the increased expression levels of cPLA2alpha and COX-2.	Dinoprostone	25-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	223-228
16675300-6	2006	The delayed synthesis of PGE2 and PGF2alpha following the stimulation for 24 with a mixture of PMA and calcium ionophore A23187 was the highest in preadipocytes, reflecting the increased expression levels of cPLA2alpha and COX-2.	Dinoprost	34-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	223-228
16675300-6	2006	The delayed synthesis of PGE2 and PGF2alpha following the stimulation for 24 with a mixture of PMA and calcium ionophore A23187 was the highest in preadipocytes, reflecting the increased expression levels of cPLA2alpha and COX-2.	Tetradecanoylphorbol Acetate	95-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	223-228
16675300-6	2006	The delayed synthesis of PGE2 and PGF2alpha following the stimulation for 24 with a mixture of PMA and calcium ionophore A23187 was the highest in preadipocytes, reflecting the increased expression levels of cPLA2alpha and COX-2.	Calcium	103-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	223-228
16675300-6	2006	The delayed synthesis of PGE2 and PGF2alpha following the stimulation for 24 with a mixture of PMA and calcium ionophore A23187 was the highest in preadipocytes, reflecting the increased expression levels of cPLA2alpha and COX-2.	Calcimycin	121-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	223-228
16423868-11	2006	Together, the data indicate an autocrine-amplifying loop involving IL-1beta-regulated Sertoli function mediated by COX-2-induced PGE(2) and PGF(2alpha) production.	Prostaglandins E	129-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-120
16289228-6	2006	Thermodynamic data pairs (DeltaH(A), DeltaS(A)) for metal binding are linearly correlated with previous data for Ca(II), Co(II) and Mg(II) binding by solid HAs.	Metals	52-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-127
16423868-11	2006	Together, the data indicate an autocrine-amplifying loop involving IL-1beta-regulated Sertoli function mediated by COX-2-induced PGE(2) and PGF(2alpha) production.	Prostaglandins F	140-143	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-120
16188370-1	2006	OBJECTIVE: To determine whether the cyclooxygenase (COX)-2 inhibitor rofecoxib increases the regression rates of cervical intraepithelial neoplasia (CIN) grade II and III.	rofecoxib	69-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-58
16831307-3	2006	Prostaglandins, catalyzed by the cyclooxygenases (COX-1 and COX-2) from arachidonic acid, are one class of these factors.	Prostaglandins	0-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-65
16831307-3	2006	Prostaglandins, catalyzed by the cyclooxygenases (COX-1 and COX-2) from arachidonic acid, are one class of these factors.	Arachidonic Acid	72-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-65
16291600-1	2006	This 2-part, double-blind, placebo-controlled study was conducted to determine the safety and efficacy of etoricoxib, a COX-2 selective inhibitor, for the treatment of hemophilic arthropathy.	Etoricoxib	106-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-125
16423868-5	2006	PGE(2) and PGF(2alpha) reverse COX-2-mediated inhibition of IL-1beta induction of cytokine expression and PG production.	Prostaglandins E	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-36
16423868-5	2006	PGE(2) and PGF(2alpha) reverse COX-2-mediated inhibition of IL-1beta induction of cytokine expression and PG production.	Prostaglandins F	11-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-36
16423868-5	2006	PGE(2) and PGF(2alpha) reverse COX-2-mediated inhibition of IL-1beta induction of cytokine expression and PG production.	Prostaglandins	0-2	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-36
16516296-5	2006	The data indicates that the E(1/2) values where electrocatalysis is initiated is related to the initial site of electron transfer, which is the Co(III)/Co(II) porphyrin reduction process in the case of (PCY)Co(2) and the Co(IV)/Co(III) corrole reduction in the case of (PCY)MnClCoCl, (PCY)FeClCoCl and (PCY)H(2)Co.	(pcy)co(2)	202-212	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-158
16516296-5	2006	The data indicates that the E(1/2) values where electrocatalysis is initiated is related to the initial site of electron transfer, which is the Co(III)/Co(II) porphyrin reduction process in the case of (PCY)Co(2) and the Co(IV)/Co(III) corrole reduction in the case of (PCY)MnClCoCl, (PCY)FeClCoCl and (PCY)H(2)Co.	co(iv)	221-227	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-158
16516296-5	2006	The data indicates that the E(1/2) values where electrocatalysis is initiated is related to the initial site of electron transfer, which is the Co(III)/Co(II) porphyrin reduction process in the case of (PCY)Co(2) and the Co(IV)/Co(III) corrole reduction in the case of (PCY)MnClCoCl, (PCY)FeClCoCl and (PCY)H(2)Co.	(pcy)mnclcocl	269-282	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-158
16516296-5	2006	The data indicates that the E(1/2) values where electrocatalysis is initiated is related to the initial site of electron transfer, which is the Co(III)/Co(II) porphyrin reduction process in the case of (PCY)Co(2) and the Co(IV)/Co(III) corrole reduction in the case of (PCY)MnClCoCl, (PCY)FeClCoCl and (PCY)H(2)Co.	(pcy)feclcocl	284-297	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-158
16516296-5	2006	The data indicates that the E(1/2) values where electrocatalysis is initiated is related to the initial site of electron transfer, which is the Co(III)/Co(II) porphyrin reduction process in the case of (PCY)Co(2) and the Co(IV)/Co(III) corrole reduction in the case of (PCY)MnClCoCl, (PCY)FeClCoCl and (PCY)H(2)Co.	(pcy)h(2)co	302-313	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-158
16516296-6	2006	The overall data also suggests that the catalytically active form of the biscobalt dyad in (PCY)Co(2) contains a Co(II) porphyrin and a Co(IV) corrole.	(pcy)co(2)	91-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-119
16385588-3	2006	Induction of COX-2 by phorbol ester was observed in RPMI-8226 and HPC cells.	Phorbol Esters	22-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
16385588-3	2006	Induction of COX-2 by phorbol ester was observed in RPMI-8226 and HPC cells.	rpmi	52-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
16385588-6	2006	Intact cells of ARH-77 converted 14C-labeled arachidonic acid to prostaglandin E2, F2alpha, and D2, and this activity was dose-dependently inhibited by selective COX-2 inhibitors (SC-58125 and NS-398), a non-selective COX inhibitor (indomethacin), and relatively high concentrations of a selective COX-1 inhibitor (SC-560).	Carbon-14	33-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	162-167
16385588-6	2006	Intact cells of ARH-77 converted 14C-labeled arachidonic acid to prostaglandin E2, F2alpha, and D2, and this activity was dose-dependently inhibited by selective COX-2 inhibitors (SC-58125 and NS-398), a non-selective COX inhibitor (indomethacin), and relatively high concentrations of a selective COX-1 inhibitor (SC-560).	Arachidonic Acid	45-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	162-167
16385588-6	2006	Intact cells of ARH-77 converted 14C-labeled arachidonic acid to prostaglandin E2, F2alpha, and D2, and this activity was dose-dependently inhibited by selective COX-2 inhibitors (SC-58125 and NS-398), a non-selective COX inhibitor (indomethacin), and relatively high concentrations of a selective COX-1 inhibitor (SC-560).	Dinoprostone	65-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	162-167
16385588-6	2006	Intact cells of ARH-77 converted 14C-labeled arachidonic acid to prostaglandin E2, F2alpha, and D2, and this activity was dose-dependently inhibited by selective COX-2 inhibitors (SC-58125 and NS-398), a non-selective COX inhibitor (indomethacin), and relatively high concentrations of a selective COX-1 inhibitor (SC-560).	f2alpha	83-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	162-167
16385588-6	2006	Intact cells of ARH-77 converted 14C-labeled arachidonic acid to prostaglandin E2, F2alpha, and D2, and this activity was dose-dependently inhibited by selective COX-2 inhibitors (SC-58125 and NS-398), a non-selective COX inhibitor (indomethacin), and relatively high concentrations of a selective COX-1 inhibitor (SC-560).	Deuterium	96-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	162-167
16385588-6	2006	Intact cells of ARH-77 converted 14C-labeled arachidonic acid to prostaglandin E2, F2alpha, and D2, and this activity was dose-dependently inhibited by selective COX-2 inhibitors (SC-58125 and NS-398), a non-selective COX inhibitor (indomethacin), and relatively high concentrations of a selective COX-1 inhibitor (SC-560).	1-((4-methylsulfonyl)phenyl)-3-trifluoromethyl-5-(4-fluorophenyl)pyrazole	180-188	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	162-167
16385588-6	2006	Intact cells of ARH-77 converted 14C-labeled arachidonic acid to prostaglandin E2, F2alpha, and D2, and this activity was dose-dependently inhibited by selective COX-2 inhibitors (SC-58125 and NS-398), a non-selective COX inhibitor (indomethacin), and relatively high concentrations of a selective COX-1 inhibitor (SC-560).	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	193-199	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	162-167
16385588-6	2006	Intact cells of ARH-77 converted 14C-labeled arachidonic acid to prostaglandin E2, F2alpha, and D2, and this activity was dose-dependently inhibited by selective COX-2 inhibitors (SC-58125 and NS-398), a non-selective COX inhibitor (indomethacin), and relatively high concentrations of a selective COX-1 inhibitor (SC-560).	Indomethacin	233-245	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	162-167
16385588-6	2006	Intact cells of ARH-77 converted 14C-labeled arachidonic acid to prostaglandin E2, F2alpha, and D2, and this activity was dose-dependently inhibited by selective COX-2 inhibitors (SC-58125 and NS-398), a non-selective COX inhibitor (indomethacin), and relatively high concentrations of a selective COX-1 inhibitor (SC-560).	SC 560	315-321	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	162-167
16385588-8	2006	Moreover, proliferation of the myeloma cells lacking COX-2 was also suppressed by 100 microM of SC-58125.	1-((4-methylsulfonyl)phenyl)-3-trifluoromethyl-5-(4-fluorophenyl)pyrazole	96-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-58
16565468-1	2006	Prostaglandins (PG) are synthesized by the sequential action of phosholipases, cyclooxygenases (COX)-1 and COX-2, and specific terminal synthases, and exert their diverse biological effects through several membrane receptors.	Prostaglandins	0-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-112
16565468-1	2006	Prostaglandins (PG) are synthesized by the sequential action of phosholipases, cyclooxygenases (COX)-1 and COX-2, and specific terminal synthases, and exert their diverse biological effects through several membrane receptors.	Prostaglandins	16-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-112
16553373-4	2006	Here, by using density functional theory calculations, we modeled the reaction route from the reaction components to the high-spin metal-oxide intermediate in the activation of oxygen molecule by 2OG-dependent enzymes for three metal ions Fe(II), Ni(II), and Co(II) in the active site.	metal-oxide	131-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	259-265
16553373-4	2006	Here, by using density functional theory calculations, we modeled the reaction route from the reaction components to the high-spin metal-oxide intermediate in the activation of oxygen molecule by 2OG-dependent enzymes for three metal ions Fe(II), Ni(II), and Co(II) in the active site.	Oxygen	177-183	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	259-265
16553373-4	2006	Here, by using density functional theory calculations, we modeled the reaction route from the reaction components to the high-spin metal-oxide intermediate in the activation of oxygen molecule by 2OG-dependent enzymes for three metal ions Fe(II), Ni(II), and Co(II) in the active site.	Metals	131-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	259-265
16553373-4	2006	Here, by using density functional theory calculations, we modeled the reaction route from the reaction components to the high-spin metal-oxide intermediate in the activation of oxygen molecule by 2OG-dependent enzymes for three metal ions Fe(II), Ni(II), and Co(II) in the active site.	ammonium ferrous sulfate	239-245	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	259-265
16523199-5	2006	This observed invasion is mediated by the arachidonic acid metabolite prostaglandin E2 and is inhibited by the Omega-3 poly-unsaturated fatty acids eicosapentaenoic acid and docosahexaenoic acid at a ratio of 1 : 2 Omega-3 : Omega-6, and by the COX-2 inhibitor NS-398.	Arachidonic Acid	42-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	245-250
16523199-5	2006	This observed invasion is mediated by the arachidonic acid metabolite prostaglandin E2 and is inhibited by the Omega-3 poly-unsaturated fatty acids eicosapentaenoic acid and docosahexaenoic acid at a ratio of 1 : 2 Omega-3 : Omega-6, and by the COX-2 inhibitor NS-398.	Dinoprostone	70-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	245-250
16523199-5	2006	This observed invasion is mediated by the arachidonic acid metabolite prostaglandin E2 and is inhibited by the Omega-3 poly-unsaturated fatty acids eicosapentaenoic acid and docosahexaenoic acid at a ratio of 1 : 2 Omega-3 : Omega-6, and by the COX-2 inhibitor NS-398.	omega-3 poly-unsaturated fatty acids	111-147	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	245-250
16523199-5	2006	This observed invasion is mediated by the arachidonic acid metabolite prostaglandin E2 and is inhibited by the Omega-3 poly-unsaturated fatty acids eicosapentaenoic acid and docosahexaenoic acid at a ratio of 1 : 2 Omega-3 : Omega-6, and by the COX-2 inhibitor NS-398.	Eicosapentaenoic Acid	148-169	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	245-250
16523199-5	2006	This observed invasion is mediated by the arachidonic acid metabolite prostaglandin E2 and is inhibited by the Omega-3 poly-unsaturated fatty acids eicosapentaenoic acid and docosahexaenoic acid at a ratio of 1 : 2 Omega-3 : Omega-6, and by the COX-2 inhibitor NS-398.	Docosahexaenoic Acids	174-194	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	245-250
16523199-5	2006	This observed invasion is mediated by the arachidonic acid metabolite prostaglandin E2 and is inhibited by the Omega-3 poly-unsaturated fatty acids eicosapentaenoic acid and docosahexaenoic acid at a ratio of 1 : 2 Omega-3 : Omega-6, and by the COX-2 inhibitor NS-398.	omega	111-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	245-250
16523199-5	2006	This observed invasion is mediated by the arachidonic acid metabolite prostaglandin E2 and is inhibited by the Omega-3 poly-unsaturated fatty acids eicosapentaenoic acid and docosahexaenoic acid at a ratio of 1 : 2 Omega-3 : Omega-6, and by the COX-2 inhibitor NS-398.	omega-6	225-232	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	245-250
16523199-5	2006	This observed invasion is mediated by the arachidonic acid metabolite prostaglandin E2 and is inhibited by the Omega-3 poly-unsaturated fatty acids eicosapentaenoic acid and docosahexaenoic acid at a ratio of 1 : 2 Omega-3 : Omega-6, and by the COX-2 inhibitor NS-398.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	261-267	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	245-250
16529457-1	2006	Metal-organic hybrids of a boronic acid (4-carboxylphenylboronic acid) with Co(II), Mn(II), and Ni(II) salts have been reported for the first time.	Metals	0-5	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-82
16529457-1	2006	Metal-organic hybrids of a boronic acid (4-carboxylphenylboronic acid) with Co(II), Mn(II), and Ni(II) salts have been reported for the first time.	Boronic Acids	27-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-82
16529457-1	2006	Metal-organic hybrids of a boronic acid (4-carboxylphenylboronic acid) with Co(II), Mn(II), and Ni(II) salts have been reported for the first time.	4-carboxylphenylboronic acid)	41-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-82
16529497-3	2006	In the first, the Co-C bond cleaves to produce Co(I) and a chlorovinyl radical, while the second pathway results in the formation of Co(II) and a chlorovinyl anion.	NAD	47-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	133-139
16529497-3	2006	In the first, the Co-C bond cleaves to produce Co(I) and a chlorovinyl radical, while the second pathway results in the formation of Co(II) and a chlorovinyl anion.	chlorovinyl radical	59-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	133-139
16519514-0	2006	Molecular dynamics simulations of arachidonic acid complexes with COX-1 and COX-2: insights into equilibrium behavior.	Arachidonic Acid	34-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-81
16519514-5	2006	We have used molecular dynamics (MD) simulations to investigate the equilibrium behavior of both COX-1 and COX-2 enzyme isoforms with bound arachidonate.	Arachidonic Acid	140-152	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-112
16519515-0	2006	Molecular dynamics simulations of arachidonic acid-derived pentadienyl radical intermediate complexes with COX-1 and COX-2: insights into oxygenation regio- and stereoselectivity.	Arachidonic Acid	34-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-122
16519515-0	2006	Molecular dynamics simulations of arachidonic acid-derived pentadienyl radical intermediate complexes with COX-1 and COX-2: insights into oxygenation regio- and stereoselectivity.	derived pentadienyl radical	51-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-122
16519515-1	2006	The two cyclooxygenase enzymes, COX-1 and COX-2, are responsible for the committed step in prostaglandin biosynthesis and are the targets of the nonsteroidal antiinflammatory drugs aspirin and ibuprofen and the COX-2 selective inhibitors, Celebrex, Vioxx, and Bextra.	Prostaglandins	91-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47
16519515-1	2006	The two cyclooxygenase enzymes, COX-1 and COX-2, are responsible for the committed step in prostaglandin biosynthesis and are the targets of the nonsteroidal antiinflammatory drugs aspirin and ibuprofen and the COX-2 selective inhibitors, Celebrex, Vioxx, and Bextra.	Prostaglandins	91-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	211-216
16519515-1	2006	The two cyclooxygenase enzymes, COX-1 and COX-2, are responsible for the committed step in prostaglandin biosynthesis and are the targets of the nonsteroidal antiinflammatory drugs aspirin and ibuprofen and the COX-2 selective inhibitors, Celebrex, Vioxx, and Bextra.	Aspirin	181-188	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47
16519515-1	2006	The two cyclooxygenase enzymes, COX-1 and COX-2, are responsible for the committed step in prostaglandin biosynthesis and are the targets of the nonsteroidal antiinflammatory drugs aspirin and ibuprofen and the COX-2 selective inhibitors, Celebrex, Vioxx, and Bextra.	Aspirin	181-188	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	211-216
16519515-1	2006	The two cyclooxygenase enzymes, COX-1 and COX-2, are responsible for the committed step in prostaglandin biosynthesis and are the targets of the nonsteroidal antiinflammatory drugs aspirin and ibuprofen and the COX-2 selective inhibitors, Celebrex, Vioxx, and Bextra.	Ibuprofen	193-202	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47
16519515-1	2006	The two cyclooxygenase enzymes, COX-1 and COX-2, are responsible for the committed step in prostaglandin biosynthesis and are the targets of the nonsteroidal antiinflammatory drugs aspirin and ibuprofen and the COX-2 selective inhibitors, Celebrex, Vioxx, and Bextra.	Ibuprofen	193-202	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	211-216
16519515-1	2006	The two cyclooxygenase enzymes, COX-1 and COX-2, are responsible for the committed step in prostaglandin biosynthesis and are the targets of the nonsteroidal antiinflammatory drugs aspirin and ibuprofen and the COX-2 selective inhibitors, Celebrex, Vioxx, and Bextra.	Celecoxib	239-247	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47
16519515-1	2006	The two cyclooxygenase enzymes, COX-1 and COX-2, are responsible for the committed step in prostaglandin biosynthesis and are the targets of the nonsteroidal antiinflammatory drugs aspirin and ibuprofen and the COX-2 selective inhibitors, Celebrex, Vioxx, and Bextra.	Celecoxib	239-247	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	211-216
16519515-1	2006	The two cyclooxygenase enzymes, COX-1 and COX-2, are responsible for the committed step in prostaglandin biosynthesis and are the targets of the nonsteroidal antiinflammatory drugs aspirin and ibuprofen and the COX-2 selective inhibitors, Celebrex, Vioxx, and Bextra.	rofecoxib	249-254	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47
16519515-1	2006	The two cyclooxygenase enzymes, COX-1 and COX-2, are responsible for the committed step in prostaglandin biosynthesis and are the targets of the nonsteroidal antiinflammatory drugs aspirin and ibuprofen and the COX-2 selective inhibitors, Celebrex, Vioxx, and Bextra.	rofecoxib	249-254	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	211-216
16519515-1	2006	The two cyclooxygenase enzymes, COX-1 and COX-2, are responsible for the committed step in prostaglandin biosynthesis and are the targets of the nonsteroidal antiinflammatory drugs aspirin and ibuprofen and the COX-2 selective inhibitors, Celebrex, Vioxx, and Bextra.	valdecoxib	260-266	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47
16519515-1	2006	The two cyclooxygenase enzymes, COX-1 and COX-2, are responsible for the committed step in prostaglandin biosynthesis and are the targets of the nonsteroidal antiinflammatory drugs aspirin and ibuprofen and the COX-2 selective inhibitors, Celebrex, Vioxx, and Bextra.	valdecoxib	260-266	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	211-216
16519515-5	2006	Herein we describe the results of explicit, 10 ns molecular dynamics simulations of both COX-1 and COX-2 with the substrate-derived pentadienyl radical intermediate bound in the active site.	pentadienyl radical	132-151	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-104
16529650-2	2006	This study aimed to investigate the efficacy of a single, oral dose of the specific COX-2 inhibitor-valdecoxib in attenuating the central sensitization - induced secondary hyperalgesia in a heat/capsaicin pain model in healthy volunteers.	valdecoxib	100-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-89
16529650-2	2006	This study aimed to investigate the efficacy of a single, oral dose of the specific COX-2 inhibitor-valdecoxib in attenuating the central sensitization - induced secondary hyperalgesia in a heat/capsaicin pain model in healthy volunteers.	Capsaicin	195-204	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-89
16203115-0	2006	Harpagoside suppresses lipopolysaccharide-induced iNOS and COX-2 expression through inhibition of NF-kappa B activation.	harpagoside	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-64
16503648-4	2006	Consequently, after validation of the docking procedure, we performed computational docking of melatonin and serotonin to structural models of the ferric and compound I and II (co I and co II, respectively) states of HRP and MPO.	Melatonin	95-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	186-191
16503648-4	2006	Consequently, after validation of the docking procedure, we performed computational docking of melatonin and serotonin to structural models of the ferric and compound I and II (co I and co II, respectively) states of HRP and MPO.	Serotonin	109-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	186-191
16503648-8	2006	The docking results, along with the previously measured heme-protein reduction potentials, suggest that the differentially lowered reaction rates of co II of HRP and MPO with respect to those of co I could stem from as yet undetermined conformational or electrostatic differences between the co I and co II states of MPO, which are absent in HRP.	Heme	56-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	149-154
16503648-8	2006	The docking results, along with the previously measured heme-protein reduction potentials, suggest that the differentially lowered reaction rates of co II of HRP and MPO with respect to those of co I could stem from as yet undetermined conformational or electrostatic differences between the co I and co II states of MPO, which are absent in HRP.	Heme	56-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	301-306
16299051-2	2006	Current dogma posits induction of COX-2 protein as the critical, obligatory event in cytokine-induced PGE2 production, although PGE2 induction can be inhibited without a concomitant inhibition of COX-2.	Dinoprostone	102-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-39
16299051-9	2006	mPGES induction and, possibly, cPLA2 induction appear to cooperate with COX-2 to determine IL-1beta-mediated PGE2 production in human ASM cells.	Dinoprostone	109-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
16596993-4	2006	TPA-induced COX-2 activity also decreased in cells exposed to extract concentrations of 10, 20, 40, and 60 microg/mL.	Tetradecanoylphorbol Acetate	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-17
16432508-6	2006	A correlation between COX-2 expression and PGI(2) and PGE(2) release was detected.	Prostaglandins I	43-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-27
16432508-6	2006	A correlation between COX-2 expression and PGI(2) and PGE(2) release was detected.	Dinoprostone	54-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-27
16432508-7	2006	Dexamethasone (DEX) inhibited SP-mediated COX-2 expression.	Dexamethasone	0-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47
16432508-7	2006	Dexamethasone (DEX) inhibited SP-mediated COX-2 expression.	Dexamethasone	15-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47
16432508-8	2006	Mitogen-activated protein kinases (MAPK) p38 and p42/44 were activated by SP, whereas SB202190 and PD98059, inhibitors of these kinases, blocked COX-2 expression.	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	86-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-150
16432508-8	2006	Mitogen-activated protein kinases (MAPK) p38 and p42/44 were activated by SP, whereas SB202190 and PD98059, inhibitors of these kinases, blocked COX-2 expression.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	99-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-150
16432508-9	2006	5,5-dimethyl-3-(3-fluorophenyl)-4-(4-methylsulphonyl)phenyl-2(5H)-furanone (DFU), an experimental selective COX-2 inhibitor, blocked SP-induced PG release.	5,5-dimethyl-3-(3-fluorophenyl)-4-(4-methylsulphonyl)phenyl-2(5h)-furanone	0-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-113
16432508-9	2006	5,5-dimethyl-3-(3-fluorophenyl)-4-(4-methylsulphonyl)phenyl-2(5H)-furanone (DFU), an experimental selective COX-2 inhibitor, blocked SP-induced PG release.	5,5-dimethyl-3-(3-fluorophenyl)-4-(4-methylsulfonyl)phenyl-2(5H)-furanone	76-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-113
16432508-9	2006	5,5-dimethyl-3-(3-fluorophenyl)-4-(4-methylsulphonyl)phenyl-2(5H)-furanone (DFU), an experimental selective COX-2 inhibitor, blocked SP-induced PG release.	Prostaglandins	144-146	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-113
16432508-11	2006	Selective NK(1) and NK(2) agonists, namely [Sar(9), Met(O(2))(11)]SP and [beta-Ala(8)] NKA(4-10), upregulated COX-2 protein expression and PG production, whereas senktide (Suc-Asp-Phe-MePhe-Gly-Leu-Met-NH(2)), a selective NK(3) agonist, was ineffective in this respect.	beta-Alanine	74-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-115
16432508-11	2006	Selective NK(1) and NK(2) agonists, namely [Sar(9), Met(O(2))(11)]SP and [beta-Ala(8)] NKA(4-10), upregulated COX-2 protein expression and PG production, whereas senktide (Suc-Asp-Phe-MePhe-Gly-Leu-Met-NH(2)), a selective NK(3) agonist, was ineffective in this respect.	suc-asp-phe-mephe-gly-leu-met-nh	172-204	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-115
16673154-2	2006	METHODS: The upstream regulatory sequences of mPGES-1, COX-1, COX-2 were respectively cloned into pGL3B-neo vector containing luciferase gene and neomycin resistance gene (the pGL3B-neo vector had been previously constructed by cloning the neomycin resistance gene into the Sal I site of the pGL3-Basic vector).	Neomycin	146-154	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
16531283-6	2006	CONCLUSIONS: COX-2 RNA levels were induced in cytokine-, peroxide-, and A2E-stressed ARPE-19 and HN cells.	Peroxides	57-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
16673154-2	2006	METHODS: The upstream regulatory sequences of mPGES-1, COX-1, COX-2 were respectively cloned into pGL3B-neo vector containing luciferase gene and neomycin resistance gene (the pGL3B-neo vector had been previously constructed by cloning the neomycin resistance gene into the Sal I site of the pGL3-Basic vector).	Neomycin	240-248	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
16673154-2	2006	METHODS: The upstream regulatory sequences of mPGES-1, COX-1, COX-2 were respectively cloned into pGL3B-neo vector containing luciferase gene and neomycin resistance gene (the pGL3B-neo vector had been previously constructed by cloning the neomycin resistance gene into the Sal I site of the pGL3-Basic vector).	sal i	274-279	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
16376453-2	2006	The mechanisms by which COX-2 exerts its mitogenic effects have not been entirely elucidated, but stimulation of prostaglandin E2 production and alterations in the expression of the cyclin-dependent kinase inhibitor p21(WAF-1/CIP1/MDA-6)(p2i) have been suggested.	Dinoprostone	113-129	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
16139839-7	2006	The DRS results indicated that the enhanced activity and selectivity of the EDF sample could be attributed to the increased concentration of isolated Co(II) inner sphere complexes of octahedral coordination, which are formed on the support surface by adsorption of the corresponding aqueous complexes, [Co(H2O)6]2+, being in the impregnating solution.	co(h2o)	303-310	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	150-156
16376453-5	2006	Instead, activation of the MEK-1/Erk pathway was necessary since COX-2 inhibitors stimulated the phosphorylation of ERKs, and their effects were blocked by PD98095, an inhibitor of this pathway.	pd98095	156-163	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-70
16376453-8	2006	Consistent with a role for p21, we found that p21 antisense oligonucleotides prevented the effects of COX-2 inhibitors on cell growth.	Oligonucleotides	60-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-107
16498361-9	2006	High levels of COX-2 expression result in higher levels of prostaglandin E2 (PGE2), which in turn increases CYP19 expression through increases in intracellular cyclic AMP levels and activation of promoter II.	Dinoprostone	59-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-20
16498361-9	2006	High levels of COX-2 expression result in higher levels of prostaglandin E2 (PGE2), which in turn increases CYP19 expression through increases in intracellular cyclic AMP levels and activation of promoter II.	Dinoprostone	77-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-20
16498361-9	2006	High levels of COX-2 expression result in higher levels of prostaglandin E2 (PGE2), which in turn increases CYP19 expression through increases in intracellular cyclic AMP levels and activation of promoter II.	Cyclic AMP	160-170	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-20
16539205-3	2006	Validation in vitro with Saos-2 osteoprogenitor cell lines showed a decrease in osteogenesis potential after the cells were treated with celecoxib, a COX-2 specific inhibitor and anti-inflammatory agent.	Celecoxib	137-146	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	150-155
16599270-1	2006	A simple, sensitive, isocratic and reproducible reversed phase HPLC method for the determination of valdecoxib, a novel specific COX-2 inhibitor in human serum was developed using a diode array detector and celecoxib as internal standard.	valdecoxib	100-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-134
16516813-0	2006	COX-1 and COX-2 contribute differentially to the LPS-induced release of PGE2 and TxA2 in liver macrophages.	Dinoprostone	72-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
16516813-3	2006	In the first 8 h after LPS addition, the specific COX-2 inhibitor SC236 inhibits the PGE2 and TxA2 release by about 80% and 20%, whereas the release of PGE2 and TxA2 between 8 and 24 h is inhibited by about 40% and 35%, respectively.	4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide	66-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-55
16516813-3	2006	In the first 8 h after LPS addition, the specific COX-2 inhibitor SC236 inhibits the PGE2 and TxA2 release by about 80% and 20%, whereas the release of PGE2 and TxA2 between 8 and 24 h is inhibited by about 40% and 35%, respectively.	Dinoprostone	85-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-55
16516813-3	2006	In the first 8 h after LPS addition, the specific COX-2 inhibitor SC236 inhibits the PGE2 and TxA2 release by about 80% and 20%, whereas the release of PGE2 and TxA2 between 8 and 24 h is inhibited by about 40% and 35%, respectively.	Dinoprostone	152-156	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-55
16516813-6	2006	Dexamethasone suppresses almost completely the LPS-induced effects on COX-2 and mPGES-1.	Dexamethasone	0-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-75
16552356-6	2006	Cyclooxygenase (COX)-2 inhibitors, NS398 and indomethacin, reversed the effects of CIP on TNF-alpha production and reduced the levels of different surface antigens, whereas a protein kinase A (PKA) inhibitor, H89, did not.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	35-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-22
16552356-6	2006	Cyclooxygenase (COX)-2 inhibitors, NS398 and indomethacin, reversed the effects of CIP on TNF-alpha production and reduced the levels of different surface antigens, whereas a protein kinase A (PKA) inhibitor, H89, did not.	Indomethacin	45-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-22
16480277-3	2006	The synthesis and biological evaluation of a novel series of sulfonanilide analogues derived from the COX-2 selective inhibitor NS-398 are described.	sulfonanilide	61-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-107
16480277-3	2006	The synthesis and biological evaluation of a novel series of sulfonanilide analogues derived from the COX-2 selective inhibitor NS-398 are described.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	128-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-107
16214349-1	2006	A series of substituted (+/-)3,5-diphenyl-2-thioxoimidazolin-4-ones was synthesized in order to design new type-2 cyclooxygenase (COX-2) inhibitors.	(+/-)3,5-diphenyl-2-thioxoimidazolin-4-ones	24-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	130-135
16429177-4	2006	This prompted us to reconsider the model formerly used for the analysis of the magnetic coupling between hs-Co(II) and the paramagnetic o-semiquinonate ligand in the corresponding derivatives [Co(Me(4)cyclam)(PhenSQ)](PF(6)) and [Co(Me(4)cyclam)(DTBSQ)](PF(6)).	o-semiquinonate	136-151	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-114
16429177-4	2006	This prompted us to reconsider the model formerly used for the analysis of the magnetic coupling between hs-Co(II) and the paramagnetic o-semiquinonate ligand in the corresponding derivatives [Co(Me(4)cyclam)(PhenSQ)](PF(6)) and [Co(Me(4)cyclam)(DTBSQ)](PF(6)).	co(me(4)cyclam)(phensq)]	193-217	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-114
16429177-4	2006	This prompted us to reconsider the model formerly used for the analysis of the magnetic coupling between hs-Co(II) and the paramagnetic o-semiquinonate ligand in the corresponding derivatives [Co(Me(4)cyclam)(PhenSQ)](PF(6)) and [Co(Me(4)cyclam)(DTBSQ)](PF(6)).	co(me(4)cyclam)	193-208	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-114
16456276-4	2006	The coordination octahedron around each CoII ion is completed by three pyridine molecules for the two outer CoII ions and by two for the inner ion.	octahedron	17-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-44
16456276-4	2006	The coordination octahedron around each CoII ion is completed by three pyridine molecules for the two outer CoII ions and by two for the inner ion.	octahedron	17-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-112
16456276-4	2006	The coordination octahedron around each CoII ion is completed by three pyridine molecules for the two outer CoII ions and by two for the inner ion.	pyridine	71-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-44
16456276-4	2006	The coordination octahedron around each CoII ion is completed by three pyridine molecules for the two outer CoII ions and by two for the inner ion.	pyridine	71-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-112
16456296-1	2006	The title compound, C30H34FNO7S, is a key intermediate in the design of dual 5-LOX (5-lipoxygenase)/COX-2 (cyclooxygenase-2) inhibitors.	c30h34fno7s	20-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-105
16454836-0	2006	The gastrointestinal safety and effect on disease activity of etoricoxib, a selective cox-2 inhibitor in inflammatory bowel diseases.	Etoricoxib	62-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-91
16454836-2	2006	Etoricoxib is a new antiinflammatory inhibitor that has high Cox-2 selectivity.	Etoricoxib	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-66
16337744-7	2006	In this regard, the recently delineated interplay between COX-2-derived PG signaling and other growth-regulatory pathways such as EGFR, Met, iNOS, VEGF and n-3 polyunsaturated fatty acids is expected to provide important therapeutic implications.	pg	72-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
16337744-7	2006	In this regard, the recently delineated interplay between COX-2-derived PG signaling and other growth-regulatory pathways such as EGFR, Met, iNOS, VEGF and n-3 polyunsaturated fatty acids is expected to provide important therapeutic implications.	Fatty Acids, Unsaturated	160-187	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
16337744-8	2006	This review summarizes the recent advances in understanding the mechanisms for COX-2-derived PG signaling in hepatocarcinogenesis and focuses on the newly unveiled interactions between PG cascade and other key signaling pathways that coordinately regulate HCC growth.	pg	93-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-84
16452198-10	2006	LY294002 also significantly inhibited the arachidonic acid-induced gene expression of COX-2, IL-1beta, GM-CSF, and ICAM1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-91
16452198-10	2006	LY294002 also significantly inhibited the arachidonic acid-induced gene expression of COX-2, IL-1beta, GM-CSF, and ICAM1.	Arachidonic Acid	42-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-91
16449211-0	2006	Atorvastatin reduces the expression of COX-2 mRNA in peripheral blood monocytes from patients with acute myocardial infarction and modulates the early inflammatory response.	Atorvastatin	0-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-44
16449211-1	2006	BACKGROUND: We examined the effect of atorvastatin on the expression of COX-2 in peripheral blood monocytes from patients with early stage of acute myocardial infarction (AMI), and the plasma C-reactive protein (CRP) concentrations were also examined.	Atorvastatin	38-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
16449211-9	2006	Atorvastatin may improve the antiinflammatory effects through the COX-2 pathway.	Atorvastatin	0-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-71
16469680-1	2006	BACKGROUND &amp; AIMS: It has been variably suggested that nonselective NSAIDs and cyclooxygenase (COX)-2 selective inhibitors aggravate or ameliorate clinical disease activity in patients with inflammatory bowel disease.	Adenosine Monophosphate	12-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-105
16469680-10	2006	Selective COX-2 inhibition with nimesulide and COX-1 inhibition with low-dose aspirin appear to be well-tolerated in the short-term.	nimesulide	32-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
16448322-4	2006	It was found that irbesartan decreased inflammatory infiltration, increased collagen content and downregulated prostaglandin E2-dependent metalloproteases as a consequence of suppression of inducible COX-2/prostaglandin E synthase.	Irbesartan	18-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	200-205
16484869-5	2006	Celecoxib is a potent selective COX-2 inhibitor.	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-37
16391822-3	2006	Indeed, we have recently observed that the dual COX-1/COX-2 inhibitor indomethacin induces apoptosis in human hepatocellular carcinoma (HCC) cell lines more effectively than the selective COX-2 inhibitors, possibly implicating COX-1 in HCC.	Indomethacin	70-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-59
16391822-9	2006	The combination of the COX-1 inhibitor with nimesulide and CAY10404, two selective COX-2 inhibitors, resulted in additive effects on cell growth inhibition.	nimesulide	44-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
16391822-9	2006	The combination of the COX-1 inhibitor with nimesulide and CAY10404, two selective COX-2 inhibitors, resulted in additive effects on cell growth inhibition.	3-(4-methylsulfonylphenyl)-4-phenyl-5-trifluoromethylisoxazole	59-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
16317058-8	2006	In addition, DHT inhibited mRNA expression of IL-6, MCP-1, CD40, TLR4, PAI-1, and Cox-2 and the release of cytokines and chemokines such as GRO, granulocyte-macrophage colony-stimulating factor, and TNF.	Dihydrotestosterone	13-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
16317058-10	2006	Furthermore, when cells were cotransfected with a Cox-2 promoter or a 3X-NF-kappaB luciferase reporter vector and a plasmid expressing the human androgen receptor, DHT treatment inhibited the increase of the luciferase activity observed with TNFalpha.	Dihydrotestosterone	164-167	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-55
16353170-2	2006	However, COX-2 inhibition also alters cellular production of other prostaglandins such as prostacyclin (PGI(2)).	Prostaglandins	67-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	9-14
16353170-2	2006	However, COX-2 inhibition also alters cellular production of other prostaglandins such as prostacyclin (PGI(2)).	Epoprostenol	90-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	9-14
16353170-2	2006	However, COX-2 inhibition also alters cellular production of other prostaglandins such as prostacyclin (PGI(2)).	Epoprostenol	104-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	9-14
16353170-4	2006	Microsomal PGES (mPGES-1) is an enzyme downstream to COX-2 and affects PGE(2) production only.	Prostaglandins E	11-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-58
16538046-8	2006	In vitro, arecoline induces the COX-2 expression of sperm cells in a dose-dependent manner.	Arecoline	10-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-37
16538046-9	2006	This is the first report to demonstrate that arecoline may mediate COX-2 expression in human sperms, resulting in inflammation response.	Arecoline	45-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-72
16331303-4	2006	Most interestingly, we found that inhibition of COX-2-mediated generation of prostaglandin (PG)-E2 in H4 neuronal cells with the preferential COX-2 inhibitor nimesulide protects against N141I PS2-mediated apoptotic cell death coincidental with an inhibition of GSK-3beta activity and subsequent normalization of beta-catenin cellular distribution.	Dinoprostone	77-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-53
16331303-4	2006	Most interestingly, we found that inhibition of COX-2-mediated generation of prostaglandin (PG)-E2 in H4 neuronal cells with the preferential COX-2 inhibitor nimesulide protects against N141I PS2-mediated apoptotic cell death coincidental with an inhibition of GSK-3beta activity and subsequent normalization of beta-catenin cellular distribution.	Dinoprostone	77-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	142-147
16331303-4	2006	Most interestingly, we found that inhibition of COX-2-mediated generation of prostaglandin (PG)-E2 in H4 neuronal cells with the preferential COX-2 inhibitor nimesulide protects against N141I PS2-mediated apoptotic cell death coincidental with an inhibition of GSK-3beta activity and subsequent normalization of beta-catenin cellular distribution.	nimesulide	158-168	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-53
16331303-4	2006	Most interestingly, we found that inhibition of COX-2-mediated generation of prostaglandin (PG)-E2 in H4 neuronal cells with the preferential COX-2 inhibitor nimesulide protects against N141I PS2-mediated apoptotic cell death coincidental with an inhibition of GSK-3beta activity and subsequent normalization of beta-catenin cellular distribution.	nimesulide	158-168	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	142-147
16391871-1	2006	Selective COX-2 inhibitors such as celecoxib and NS-398 are being evaluated as chemopreventive and therapeutic agents for bladder and other cancers.	Celecoxib	35-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
16391871-1	2006	Selective COX-2 inhibitors such as celecoxib and NS-398 are being evaluated as chemopreventive and therapeutic agents for bladder and other cancers.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	49-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
16391871-12	2006	COX-2 selective inhibitors NS-398 and celecoxib produced dose-dependent growth inhibition of bladder cancer cells associated with a significant reduction in S-phase.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	27-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
16391871-12	2006	COX-2 selective inhibitors NS-398 and celecoxib produced dose-dependent growth inhibition of bladder cancer cells associated with a significant reduction in S-phase.	Celecoxib	38-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
15979396-1	2006	Ternary complexes of Co(II), Ni(II) and Cu(II) with indole-2-carboxylic acid (A) and 4-substituted hydrazinethiocarbamide (L) [4-phenylhydrazinethiocarbamide (L1), 4-benzylhydrazinethiocarbamide (L2) and 4-(2-propenyl)hydrazinethiocarbamide (L3)] were prepared.	indole-2-carboxylic acid	52-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-27
15979396-1	2006	Ternary complexes of Co(II), Ni(II) and Cu(II) with indole-2-carboxylic acid (A) and 4-substituted hydrazinethiocarbamide (L) [4-phenylhydrazinethiocarbamide (L1), 4-benzylhydrazinethiocarbamide (L2) and 4-(2-propenyl)hydrazinethiocarbamide (L3)] were prepared.	4-substituted hydrazinethiocarbamide	85-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-27
15979396-1	2006	Ternary complexes of Co(II), Ni(II) and Cu(II) with indole-2-carboxylic acid (A) and 4-substituted hydrazinethiocarbamide (L) [4-phenylhydrazinethiocarbamide (L1), 4-benzylhydrazinethiocarbamide (L2) and 4-(2-propenyl)hydrazinethiocarbamide (L3)] were prepared.	4-phenylhydrazinethiocarbamide	127-157	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-27
15979396-1	2006	Ternary complexes of Co(II), Ni(II) and Cu(II) with indole-2-carboxylic acid (A) and 4-substituted hydrazinethiocarbamide (L) [4-phenylhydrazinethiocarbamide (L1), 4-benzylhydrazinethiocarbamide (L2) and 4-(2-propenyl)hydrazinethiocarbamide (L3)] were prepared.	4-benzylhydrazinethiocarbamide	164-194	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-27
15979396-1	2006	Ternary complexes of Co(II), Ni(II) and Cu(II) with indole-2-carboxylic acid (A) and 4-substituted hydrazinethiocarbamide (L) [4-phenylhydrazinethiocarbamide (L1), 4-benzylhydrazinethiocarbamide (L2) and 4-(2-propenyl)hydrazinethiocarbamide (L3)] were prepared.	4-(2-propenyl)hydrazinethiocarbamide	204-240	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-27
15979396-3	2006	An octahedral structure is suggested for Co(II), Ni(II) and Cu(II) ternary complexes.	cu(ii)	60-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-47
15996511-0	2006	Synthesis, characterization and thermal behavior of 4-chloromethyl-2-(2-hydroxybenzilidenehydrazino) thiazole and its complexes with Cr(III), Co(II), Ni(II) and Cu(II).	4-chloromethyl-2-(2-hydroxybenzilidenehydrazino) thiazole	52-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	142-148
15996511-2	2006	Metal complexes of the ligand were prepared from acetate salts of Co(II), Cu(II), Ni(II) and chloride of Cr(III) in dry acetone.	Metals	0-5	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-72
15996511-2	2006	Metal complexes of the ligand were prepared from acetate salts of Co(II), Cu(II), Ni(II) and chloride of Cr(III) in dry acetone.	Acetates	49-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-72
15996511-4	2006	In the light of these results, it was suggested that two ligands coordinate to each metal atom by hydroxyl oxygen, imino nitrogen and thiazole ring nitrogen to form high spin octahedral complexes with Cr(III), Co(II), Ni(II) and Cu(II).	Metals	84-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	210-216
15996511-4	2006	In the light of these results, it was suggested that two ligands coordinate to each metal atom by hydroxyl oxygen, imino nitrogen and thiazole ring nitrogen to form high spin octahedral complexes with Cr(III), Co(II), Ni(II) and Cu(II).	Oxygen	107-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	210-216
15996511-4	2006	In the light of these results, it was suggested that two ligands coordinate to each metal atom by hydroxyl oxygen, imino nitrogen and thiazole ring nitrogen to form high spin octahedral complexes with Cr(III), Co(II), Ni(II) and Cu(II).	imino nitrogen	115-129	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	210-216
15996511-4	2006	In the light of these results, it was suggested that two ligands coordinate to each metal atom by hydroxyl oxygen, imino nitrogen and thiazole ring nitrogen to form high spin octahedral complexes with Cr(III), Co(II), Ni(II) and Cu(II).	Thiazoles	134-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	210-216
15996511-4	2006	In the light of these results, it was suggested that two ligands coordinate to each metal atom by hydroxyl oxygen, imino nitrogen and thiazole ring nitrogen to form high spin octahedral complexes with Cr(III), Co(II), Ni(II) and Cu(II).	Nitrogen	121-129	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	210-216
15996511-4	2006	In the light of these results, it was suggested that two ligands coordinate to each metal atom by hydroxyl oxygen, imino nitrogen and thiazole ring nitrogen to form high spin octahedral complexes with Cr(III), Co(II), Ni(II) and Cu(II).	cu(ii)	229-235	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	210-216
16098805-1	2006	The complexes of orotic acid with Co(II), Ni(II), Fe(III), Cu(II), and Cd(II) were prepared and their stoichiometry were determined by elemental analysis.	Orotic Acid	17-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-40
16098805-2	2006	Co(II) and Ni(II) give complexes with orotic acid of 1:1 ratio whereas that of the remaining transition metals give complexes of 1:2 ratio.	Orotic Acid	38-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
18970495-5	2006	Diethyldithiocarbomate (DDC) in a cationic micellar solution of cetyltrimethylammonium bromide (CTAB) was used for determination of Fe(II), Co(II) and Cu(II) at pH 5.50.	diethyldithiocarbomate	0-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-146
18970495-5	2006	Diethyldithiocarbomate (DDC) in a cationic micellar solution of cetyltrimethylammonium bromide (CTAB) was used for determination of Fe(II), Co(II) and Cu(II) at pH 5.50.	Zalcitabine	24-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-146
18970495-5	2006	Diethyldithiocarbomate (DDC) in a cationic micellar solution of cetyltrimethylammonium bromide (CTAB) was used for determination of Fe(II), Co(II) and Cu(II) at pH 5.50.	Cetrimonium	96-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-146
18970495-7	2006	The proposed method was successfully applied to the simultaneous determination of Fe(II), Co(II) and Cu(II) in several synthetic mixtures containing different concentration of Fe(II), Co(II) and Cu(II).	ammonium ferrous sulfate	82-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	184-190
18970495-7	2006	The proposed method was successfully applied to the simultaneous determination of Fe(II), Co(II) and Cu(II) in several synthetic mixtures containing different concentration of Fe(II), Co(II) and Cu(II).	cu(ii)	101-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	184-190
18970495-7	2006	The proposed method was successfully applied to the simultaneous determination of Fe(II), Co(II) and Cu(II) in several synthetic mixtures containing different concentration of Fe(II), Co(II) and Cu(II).	ammonium ferrous sulfate	176-182	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-96
18970495-7	2006	The proposed method was successfully applied to the simultaneous determination of Fe(II), Co(II) and Cu(II) in several synthetic mixtures containing different concentration of Fe(II), Co(II) and Cu(II).	cu(ii)	195-201	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-96
16458114-12	2006	Western blotting showed that the expression of COX-2 was always higher in the HeLa/bcl-2 cells than in the HeLa/vector cells under the both of treated and untreated with H2O2, while the level of COX-1 was relative stable in the both strains.	Hydrogen Peroxide	170-174	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
16435846-0	2006	Phosphonation of arenes with dialkyl phosphites catalyzed by Mn(II)/Co(II)/O2 redox couple.	arenes	17-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-74
16435846-0	2006	Phosphonation of arenes with dialkyl phosphites catalyzed by Mn(II)/Co(II)/O2 redox couple.	dialkyl phosphites	29-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-74
16435846-0	2006	Phosphonation of arenes with dialkyl phosphites catalyzed by Mn(II)/Co(II)/O2 redox couple.	Manganese(2+)	61-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-74
16435846-0	2006	Phosphonation of arenes with dialkyl phosphites catalyzed by Mn(II)/Co(II)/O2 redox couple.	Oxygen	75-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-74
16427740-3	2006	cis-9, trans-11 CLA and trans-10, cis-12 CLA were shown to reduce proportions of the eicosanoid precursor arachidonic acid in SMC total lipids and to inhibit cytokine-induced NF-kappaB DNA-binding activity, mRNA levels of inducible enzymes involved in eicosanoid formation (cPLA2, COX-2, mPGES), and the production of the prostaglandins PGE2 and PGI2 by TNFalpha-stimulated SMCs in a dose-dependent manner.	cis-9	0-5	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	281-286
16427740-3	2006	cis-9, trans-11 CLA and trans-10, cis-12 CLA were shown to reduce proportions of the eicosanoid precursor arachidonic acid in SMC total lipids and to inhibit cytokine-induced NF-kappaB DNA-binding activity, mRNA levels of inducible enzymes involved in eicosanoid formation (cPLA2, COX-2, mPGES), and the production of the prostaglandins PGE2 and PGI2 by TNFalpha-stimulated SMCs in a dose-dependent manner.	trans-10	24-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	281-286
16376453-3	2006	Here, we demonstrate that two COX-2 inhibitors (NS398 and Nimesulide) inhibit proliferation and induce apoptosis in NSCLC cells, and these effects were associated with induction of p21 mRNA and protein expression.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	48-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-35
16376453-3	2006	Here, we demonstrate that two COX-2 inhibitors (NS398 and Nimesulide) inhibit proliferation and induce apoptosis in NSCLC cells, and these effects were associated with induction of p21 mRNA and protein expression.	nimesulide	58-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-35
16462098-1	2006	Meloxicam (MLX), a non-steroidal anti-inflammatory drug (NSAID) and a selective COX-2 inhibitor is a water insoluble drug (about 12 microg/ml).	Meloxicam	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-85
16462098-1	2006	Meloxicam (MLX), a non-steroidal anti-inflammatory drug (NSAID) and a selective COX-2 inhibitor is a water insoluble drug (about 12 microg/ml).	Water	101-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-85
16430228-1	2006	In an effort to probe Co(II) binding to metallo-beta-lactamase CcrA, EPR, EXAFS, and (1)H NMR studies were conducted on CcrA containing 1 equiv (1-Co(II)-CcrA) and 2 equiv (Co(II)Co(II)-CcrA) of Co(II).	ccra	63-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-28
16430228-4	2006	EXAFS spectra of 1-Co(II)-CcrA suggest 5/6-coordinate Co(II) with two or more histidine ligands.	Histidine	78-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-25
16430228-7	2006	The data indicate sequential binding of Co(II) to CcrA and that the first Co(II) binds to the consensus Zn(1) site in the enzyme.	ccra	50-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-46
16430228-7	2006	The data indicate sequential binding of Co(II) to CcrA and that the first Co(II) binds to the consensus Zn(1) site in the enzyme.	zn(1)	104-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-80
16677505-1	2006	OBJECTIVE: To investigate the regulative roles of the gastrin receptor antagonist proglumide and the specific cyclooxygenase (COX)-2 inhibitor NS-398 on the proliferation and apoptosis of gastric cancer cells.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	143-149	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-132
17723355-2	2006	Although the complexes of Fe(II), Ni(II) and Co(II) with reagent show a spectral overlap, they have been simultaneously determined by partial least squares (PLS) with and without preprocessing step using direct orthogonal signal correction (DOSC).	ammonium ferrous sulfate	26-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-51
16290292-0	2006	QSAR analysis of meclofenamic acid analogues as selective COX-2 inhibitors.	Meclofenamic Acid	17-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
16290292-4	2006	Presented herein is a series of 21 derivatives of meclofenamic acid with selective COX-2 inhibitory activity.	Meclofenamic Acid	50-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
16300728-0	2006	Induction of COX-2 protein expression by vanadate in A549 human lung carcinoma cell line through EGF receptor and p38 MAPK-mediated pathway.	Vanadates	41-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
16300728-4	2006	Here, we found that exposure of A549 human lung carcinoma cells to vanadate led to extracellular signal-regulated kinase, c-Jun NH(2)-terminal protein kinases (JNKs), p38 mitogen-activated protein kinase (p38) activation, and COX-2 protein expression in a dose-dependent manner.	Vanadates	67-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	226-231
16300728-5	2006	SB203580, a p38 MAPK inhibitor, but not PD098059 and SP600125, specific inhibitor of MKK1 and selective inhibitor of JNK, respectively, suppressed COX-2 expression.	SB 203580	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-152
16300728-6	2006	Furthermore, the epithelial growth factor (EGF) receptor specific inhibitor (PD153035) reduced vanadate-induced COX-2 expression.	4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline	77-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-117
16300728-6	2006	Furthermore, the epithelial growth factor (EGF) receptor specific inhibitor (PD153035) reduced vanadate-induced COX-2 expression.	Vanadates	95-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-117
16300728-8	2006	Together, we suggested that EGF receptor and p38 MAPK signaling pathway may be involved in vanadate-induced COX-2 protein expression in A549 human lung carcinoma cell line.	Vanadates	91-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-113
16342307-0	2006	Co(II) chemistry of 2,6-bis(2-pyridylcarbonyl)pyridine: an icosanuclear Co cluster exhibiting superparamagnetic relaxation.	2,6-bis(2-pyridylcarbonyl)pyridine	20-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
16339488-12	2006	Furthermore, COX-2-dependent prostaglandins may play a key role in the regulation of HA synthesis in arterialized vein grafts.	Prostaglandins	29-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
17168490-0	2006	[Usage of the new parenteral selective cox-2 inhibitor dynastat in the gynecologic practice].	parecoxib	55-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-44
17168490-6	2006	In conclusion we accept that the new COX-2 selective inhibitor Dynastat does not have advantages over traditional nonsteroidal anti-inflammatory drug as Profenid especially for postoperative nausea and vomiting and quality of analgesia.	parecoxib	63-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-42
16143655-2	2006	Prostaglandins that have been implicated in this process are synthesized by two isoforms of cyclooxygenase (COX), with the expression of the regulated COX-2 isoform increased in atherosclerotic plaques.	Prostaglandins	0-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-156
16143655-4	2006	We hypothesized that BK plays an important role in the regulation of COX-2, contributing to the increase in production of prostaglandins in vascular smooth muscle cells.	Prostaglandins	122-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-74
16356188-13	2006	Inhibition of prostaglandin E2 production indirectly showed that all NSAIDs inhibited COX, with the more COX-2 specific agents having more pronounced effects.	Dinoprostone	14-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-110
16525617-0	2006	[The inhibitive effect of COX-2 inhibitor NS-398 on cancer cell growth of human tongue squamous cell carcinoma].	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	42-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-31
16525617-1	2006	PURPOSE: To investigate the inhibitive effect of COX-2 inhibitor NS-398 on cancer cell growth of human tongue squamous cell carcinoma.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	65-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-54
16330178-0	2006	Inhibition of COX-1 and COX-2 activity by plasma of human volunteers after ingestion of French maritime pine bark extract (Pycnogenol).	pycnogenols	123-133	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
17497004-3	2006	The complexes of Co(II) with phthalocyanines are extremely good catalysts of oxidation of organic compounds with molecular oxygen and hydrogen peroxide.	phthalocyanine	29-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22
17497004-3	2006	The complexes of Co(II) with phthalocyanines are extremely good catalysts of oxidation of organic compounds with molecular oxygen and hydrogen peroxide.	Oxygen	123-129	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22
17497004-3	2006	The complexes of Co(II) with phthalocyanines are extremely good catalysts of oxidation of organic compounds with molecular oxygen and hydrogen peroxide.	Hydrogen Peroxide	134-151	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22
17497004-4	2006	In this study, we have investigated the kinetics and thermodynamics of sequence-specific modification of DNA with deoxyribooligonucleotide linked to Co(II)-tetracarboxyphthalocyanine (PtcCo(II)) in the presence of H(2)O(2).	deoxyribooligonucleotide	114-138	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	149-154
17497004-4	2006	In this study, we have investigated the kinetics and thermodynamics of sequence-specific modification of DNA with deoxyribooligonucleotide linked to Co(II)-tetracarboxyphthalocyanine (PtcCo(II)) in the presence of H(2)O(2).	ptcco(ii)	184-193	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	149-154
16352870-4	2006	Coincubation of DEX-treated arteries with INDO for 4 h reversed this DEX-induced attenuation in 5-HT contractile efficacy, although DEX had no significant effects on cyclooxygenase (COX)-1 and COX-2 protein abundance.	Dexamethasone	16-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	193-198
17497004-4	2006	In this study, we have investigated the kinetics and thermodynamics of sequence-specific modification of DNA with deoxyribooligonucleotide linked to Co(II)-tetracarboxyphthalocyanine (PtcCo(II)) in the presence of H(2)O(2).	Hydrogen Peroxide	214-222	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	149-154
17497006-2	2006	n(INH-DCB) [M = Co(II) or Ni(II), X = Cl(-) ,Br(-), NO(3) (-), NCS(-), or CH(3)COO(-), n = 2; X = ClO(4) (-), n = 3] have been synthesized.	dcb	6-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-22
16352870-4	2006	Coincubation of DEX-treated arteries with INDO for 4 h reversed this DEX-induced attenuation in 5-HT contractile efficacy, although DEX had no significant effects on cyclooxygenase (COX)-1 and COX-2 protein abundance.	Indomethacin	42-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	193-198
17497012-3	2006	Metallophthalocyanines were able to induce the DNA modification: phthalocyanines of Zn(II) and Al(III) were active as photosensitizers in the generation of singlet oxygen (1)O(2), while phthalocyanine of Co(II) promoted DNA oxidation by molecular oxygen through the catalysis of formation of reactive oxygen species ((.	metallophthalocyanines	0-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	204-210
17497012-3	2006	Metallophthalocyanines were able to induce the DNA modification: phthalocyanines of Zn(II) and Al(III) were active as photosensitizers in the generation of singlet oxygen (1)O(2), while phthalocyanine of Co(II) promoted DNA oxidation by molecular oxygen through the catalysis of formation of reactive oxygen species ((.	phthalocyanine	7-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	204-210
17497012-3	2006	Metallophthalocyanines were able to induce the DNA modification: phthalocyanines of Zn(II) and Al(III) were active as photosensitizers in the generation of singlet oxygen (1)O(2), while phthalocyanine of Co(II) promoted DNA oxidation by molecular oxygen through the catalysis of formation of reactive oxygen species ((.	Zinc	84-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	204-210
17497012-3	2006	Metallophthalocyanines were able to induce the DNA modification: phthalocyanines of Zn(II) and Al(III) were active as photosensitizers in the generation of singlet oxygen (1)O(2), while phthalocyanine of Co(II) promoted DNA oxidation by molecular oxygen through the catalysis of formation of reactive oxygen species ((.	al(iii)	95-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	204-210
16912414-9	2006	The data obtained using human chondrocytes demonstrate that IL-1beta induced *NO and PGE2 release via an iNOS-driven-COX-2 inter-dependent pathway.	Dinoprostone	85-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-122
17497012-3	2006	Metallophthalocyanines were able to induce the DNA modification: phthalocyanines of Zn(II) and Al(III) were active as photosensitizers in the generation of singlet oxygen (1)O(2), while phthalocyanine of Co(II) promoted DNA oxidation by molecular oxygen through the catalysis of formation of reactive oxygen species ((.	phthalocyanine	7-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	204-210
17497012-6	2006	A conjugate of Co(II)-tetracarboxyphthalocyanine with the oligonucleotide was found to modify the DNA target in the presence of O(2) and 2-mercaptoethanol or in the presence of H(2)O(2).	Oligonucleotides	58-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-21
17497012-6	2006	A conjugate of Co(II)-tetracarboxyphthalocyanine with the oligonucleotide was found to modify the DNA target in the presence of O(2) and 2-mercaptoethanol or in the presence of H(2)O(2).	Oxygen	128-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-21
17497012-6	2006	A conjugate of Co(II)-tetracarboxyphthalocyanine with the oligonucleotide was found to modify the DNA target in the presence of O(2) and 2-mercaptoethanol or in the presence of H(2)O(2).	Mercaptoethanol	137-154	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-21
17497012-6	2006	A conjugate of Co(II)-tetracarboxyphthalocyanine with the oligonucleotide was found to modify the DNA target in the presence of O(2) and 2-mercaptoethanol or in the presence of H(2)O(2).	Hydrogen Peroxide	177-185	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-21
16760127-1	2006	It has been reported that when ovarian carcinoma cell lines are exposed to various concentrations of celecoxib, a COX-2 inhibitor, cell growth is decreased in a dose dependant manner.	Celecoxib	101-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-119
17181859-3	2006	We hypothesized that genetic polymorphisms (COX-2 .926, COX-2 .5209, and COX-2 .8473) may reduce overall breast cancer risk or risk for subtypes of breast cancer by modulating the inflammatory response and may interact with aspirin or any NSAID use.	Aspirin	224-231	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-49
17181859-3	2006	We hypothesized that genetic polymorphisms (COX-2 .926, COX-2 .5209, and COX-2 .8473) may reduce overall breast cancer risk or risk for subtypes of breast cancer by modulating the inflammatory response and may interact with aspirin or any NSAID use.	Aspirin	224-231	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-61
17181859-3	2006	We hypothesized that genetic polymorphisms (COX-2 .926, COX-2 .5209, and COX-2 .8473) may reduce overall breast cancer risk or risk for subtypes of breast cancer by modulating the inflammatory response and may interact with aspirin or any NSAID use.	Aspirin	224-231	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-61
17473370-4	2006	In the tumors, the major cyclooxygenase (COX)-2 product is prostaglandin E2(PGE2) which suppresses T and NK cells while amplifying Treg.	Dinoprostone	59-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-47
17473370-4	2006	In the tumors, the major cyclooxygenase (COX)-2 product is prostaglandin E2(PGE2) which suppresses T and NK cells while amplifying Treg.	Dinoprostone	76-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-47
17121069-8	2006	CONCLUSIONS: Short-term COX-2 inhibition in patients with moderate renal impairment was associated with significant decrease of tubular transport of sodium, without changing GFR and water excretion.	Sodium	149-155	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
16340194-2	2006	Curcumin, a major yellow pigment in turmeric which is used widely all over the world, inhibits the growth of human colon cancer cell line HT-29 significantly and specifically inhibits the expression of COX-2 protein.	Curcumin	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	202-207
16340194-6	2006	The inhibition of COX-2 expression after treatment with the curcumin-5-FU combination was also evaluated by Western blot analysis.	curcumin-5-fu	60-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-23
16412030-3	2006	There is a large amount of data that suggest traditional NSAIDs, as well as the new cyclooxygenase (COX)-2 selective inhibitors such as rofecoxib and celecoxib, have a role in the setting of primary and secondary prevention, and adjuvant therapy of both sporadic colorectal carcinoma and familial adenomatous polyposis.	rofecoxib	136-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-106
16412030-3	2006	There is a large amount of data that suggest traditional NSAIDs, as well as the new cyclooxygenase (COX)-2 selective inhibitors such as rofecoxib and celecoxib, have a role in the setting of primary and secondary prevention, and adjuvant therapy of both sporadic colorectal carcinoma and familial adenomatous polyposis.	Celecoxib	150-159	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-106
16395396-1	2006	Inhibitors selective for prostaglandin G/H synthase-2 (PGHS-2) (known colloquially as COX-2) were designed to minimize gastrointestinal complications of traditional NSAIDs--adverse effects attributed to suppression of COX-1-derived PGE2 and prostacyclin (PGI2).	Dinoprostone	232-236	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-91
16912414-0	2006	Dynamic compression counteracts IL-1beta induced iNOS and COX-2 activity by human chondrocytes cultured in agarose constructs.	Sepharose	107-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
16842185-2	2006	Their synthesis is dependent on two cyclooxygenase (COX) enzymes, COX-1 and COX-2, which are rate-limiting for the production of prostaglandins (PGs) and thromboxanes from free arachidonic acid.	Prostaglandins	129-143	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-81
16842185-2	2006	Their synthesis is dependent on two cyclooxygenase (COX) enzymes, COX-1 and COX-2, which are rate-limiting for the production of prostaglandins (PGs) and thromboxanes from free arachidonic acid.	Prostaglandins	145-148	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-81
16842185-2	2006	Their synthesis is dependent on two cyclooxygenase (COX) enzymes, COX-1 and COX-2, which are rate-limiting for the production of prostaglandins (PGs) and thromboxanes from free arachidonic acid.	Thromboxanes	154-166	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-81
16842185-2	2006	Their synthesis is dependent on two cyclooxygenase (COX) enzymes, COX-1 and COX-2, which are rate-limiting for the production of prostaglandins (PGs) and thromboxanes from free arachidonic acid.	Arachidonic Acid	177-193	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-81
17017909-10	2006	Likewise, a possible down-regulation of COX-2 by omega-3 fatty acids has been suggested.	Fatty Acids, Omega-3	49-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
16454737-8	2006	Prostacyclins are powerful vasodilators and potent inhibitors of platelet aggregation which are produced from free arachidonic acid through the catalytic activity of two COX: COX-1 and COX-2.	Prostaglandins I	0-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	185-190
16454737-8	2006	Prostacyclins are powerful vasodilators and potent inhibitors of platelet aggregation which are produced from free arachidonic acid through the catalytic activity of two COX: COX-1 and COX-2.	Arachidonic Acid	115-131	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	185-190
16341840-1	2006	AIMS/HYPOTHESIS: The cyclooxygenase-2 (PTGS2, previously known as COX2) enzyme and its products, such as prostaglandin E(2) (PGE(2)), have been implicated in the pathogenesis of several inflammatory diseases including islet dysfunction under diabetic conditions.	Dinoprostone	105-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-70
16341840-1	2006	AIMS/HYPOTHESIS: The cyclooxygenase-2 (PTGS2, previously known as COX2) enzyme and its products, such as prostaglandin E(2) (PGE(2)), have been implicated in the pathogenesis of several inflammatory diseases including islet dysfunction under diabetic conditions.	Prostaglandins E	125-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-70
16784252-17	2006	The phase II clinical programme for nitronaproxen, which included 2709 patients in five separate clinical studies, showed that the drug is a potent, safe anti-inflammatory agent, with potential for improved cardiovascular safety over NSAIDs and COX-2 selective NSAIDs.	nitronaproxen	36-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	245-250
16869344-4	2006	Furthermore, concomitant aspirin use substantially reduces the gastrointestinal safety advantage of COX-2-selective drugs.	Aspirin	25-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-105
16367757-3	2006	Here, we show that the 4-hydroxytamoxifen (4-OHT) mediated activation of a C-Raf-estrogen receptor fusion protein leads to the induction of both the PPARbeta and Cox-2 genes, concomitant with a dramatic increase in PGI2 synthesis.	hydroxytamoxifen	23-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	162-167
16367757-3	2006	Here, we show that the 4-hydroxytamoxifen (4-OHT) mediated activation of a C-Raf-estrogen receptor fusion protein leads to the induction of both the PPARbeta and Cox-2 genes, concomitant with a dramatic increase in PGI2 synthesis.	4,17 beta-dihydroxy-4-androstene-3-one	43-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	162-167
16367757-3	2006	Here, we show that the 4-hydroxytamoxifen (4-OHT) mediated activation of a C-Raf-estrogen receptor fusion protein leads to the induction of both the PPARbeta and Cox-2 genes, concomitant with a dramatic increase in PGI2 synthesis.	Epoprostenol	215-219	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	162-167
16401468-4	2006	We examined the variability in degree and selectivity of COX-2 inhibition in humans in response to celecoxib and rofecoxib.	Celecoxib	99-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-62
16401468-4	2006	We examined the variability in degree and selectivity of COX-2 inhibition in humans in response to celecoxib and rofecoxib.	rofecoxib	113-122	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-62
16340663-4	2006	Experimental studies suggest that uric acid induce its detrimental effects at the cellular level entering to vascular smooth muscle cells (VSMC) via an organic anion transport system, and followed by the activation of specific MAP kinases, nuclear transcription factors, with stimulation of COX-2, PDGF A and C chain, PDGF alpha receptor, and various inflammatory mediators, including C-reactive protein and monocyte chemoattractant protein-1.	Uric Acid	34-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	291-296
16529558-5	2006	Recent reports evidence that selective COX-2 inhibitor such as rofecoxib, can lead to thrombotic cardiovascular events through inhibition of prostacyclin formation in the infracted heart.	rofecoxib	63-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-44
16529558-5	2006	Recent reports evidence that selective COX-2 inhibitor such as rofecoxib, can lead to thrombotic cardiovascular events through inhibition of prostacyclin formation in the infracted heart.	Epoprostenol	141-153	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-44
16529558-7	2006	Moreover, the COX-2/COX-1 selectivity ratio is vital in the design of COX-2 inhibitory drugs, as it is clear from rofecoxib, which is more than 50-fold COX-2 selective.	rofecoxib	114-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
16529558-7	2006	Moreover, the COX-2/COX-1 selectivity ratio is vital in the design of COX-2 inhibitory drugs, as it is clear from rofecoxib, which is more than 50-fold COX-2 selective.	rofecoxib	114-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-75
16529558-7	2006	Moreover, the COX-2/COX-1 selectivity ratio is vital in the design of COX-2 inhibitory drugs, as it is clear from rofecoxib, which is more than 50-fold COX-2 selective.	rofecoxib	114-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-75
16842204-6	2006	The other enzyme, COX2, is induced by inflammatory stimuli and it is prostaglandins made by this enzyme that contribute to the inflammation in diseases such as rheumatoid arthritis.	Prostaglandins	69-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-22
17168729-4	2006	Two evidences playing important roles for the inhibition by the active compounds, are 1) C-1 and C-3" hydroxyl groups formed hydrogen bonds with COX-2/COX-1 Val523/Ile523 and Arg120, respectively, 2) hydrogen at C-5 of the naphthalene nucleus was attracted rather close to the phenolic group of Tyr385 due to van der Waals interaction.	Hydrogen	125-133	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-150
17168729-4	2006	Two evidences playing important roles for the inhibition by the active compounds, are 1) C-1 and C-3" hydroxyl groups formed hydrogen bonds with COX-2/COX-1 Val523/Ile523 and Arg120, respectively, 2) hydrogen at C-5 of the naphthalene nucleus was attracted rather close to the phenolic group of Tyr385 due to van der Waals interaction.	Hydrogen	200-208	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-150
17168729-4	2006	Two evidences playing important roles for the inhibition by the active compounds, are 1) C-1 and C-3" hydroxyl groups formed hydrogen bonds with COX-2/COX-1 Val523/Ile523 and Arg120, respectively, 2) hydrogen at C-5 of the naphthalene nucleus was attracted rather close to the phenolic group of Tyr385 due to van der Waals interaction.	naphthalene	223-234	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-150
16533160-3	2006	This review provides information regarding the most current advances in the findings of the molecular mechanisms for PGI(2) biosynthesis in the endoplasmic reticulum (ER) membrane through the coordination between PGI(2) synthase and its upstream enzymes, cyclooxygenase-1 (COX-1) or -2 (COX-2), and for PGI(2) signaling through its cell membrane receptors and nuclear peroxisome proliferator-activated receptors.	Epoprostenol	117-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	287-292
16533160-3	2006	This review provides information regarding the most current advances in the findings of the molecular mechanisms for PGI(2) biosynthesis in the endoplasmic reticulum (ER) membrane through the coordination between PGI(2) synthase and its upstream enzymes, cyclooxygenase-1 (COX-1) or -2 (COX-2), and for PGI(2) signaling through its cell membrane receptors and nuclear peroxisome proliferator-activated receptors.	Prostaglandins I	117-120	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	287-292
16533160-3	2006	This review provides information regarding the most current advances in the findings of the molecular mechanisms for PGI(2) biosynthesis in the endoplasmic reticulum (ER) membrane through the coordination between PGI(2) synthase and its upstream enzymes, cyclooxygenase-1 (COX-1) or -2 (COX-2), and for PGI(2) signaling through its cell membrane receptors and nuclear peroxisome proliferator-activated receptors.	Epoprostenol	213-219	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	287-292
16544582-2	2006	Rofecoxib (R) is a novel and specific COX-2 inhibitor which is caracterized by an highly selective COX-2 inhibition, and can be presumed as non cross-reactive with ASA.	rofecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-43
16544582-2	2006	Rofecoxib (R) is a novel and specific COX-2 inhibitor which is caracterized by an highly selective COX-2 inhibition, and can be presumed as non cross-reactive with ASA.	rofecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-104
16544582-16	2006	CONCLUSIONS: Despite ASA, Rofecoxib, largely due to its highly specificity for COX-2, proved a drug particularly safe in treating patients with AIA.	rofecoxib	26-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-84
16118353-5	2006	COX-2 derived prostaglandin E(2)(PGE(2)) can promote tumour growth by binding its receptors and activating signalling pathways which control cell proliferation, migration, apoptosis, and/or angiogenesis.	Dinoprostone	14-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
16118353-5	2006	COX-2 derived prostaglandin E(2)(PGE(2)) can promote tumour growth by binding its receptors and activating signalling pathways which control cell proliferation, migration, apoptosis, and/or angiogenesis.	Dinoprostone	33-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
16785827-6	2006	COX-2 metabolites have been implicated in the mediation of renin release, regulation of sodium excretion, and maintenance of renal blood flow.	Sodium	88-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
16395396-1	2006	Inhibitors selective for prostaglandin G/H synthase-2 (PGHS-2) (known colloquially as COX-2) were designed to minimize gastrointestinal complications of traditional NSAIDs--adverse effects attributed to suppression of COX-1-derived PGE2 and prostacyclin (PGI2).	Epoprostenol	241-253	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-91
16395396-1	2006	Inhibitors selective for prostaglandin G/H synthase-2 (PGHS-2) (known colloquially as COX-2) were designed to minimize gastrointestinal complications of traditional NSAIDs--adverse effects attributed to suppression of COX-1-derived PGE2 and prostacyclin (PGI2).	Epoprostenol	255-259	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-91
16395396-4	2006	The clinical information is biologically plausible, as it is compatible with evidence that inhibition of COX-2-derived PGI2 removes a protective constraint on thrombogenesis, hypertension, and atherogenesis in vivo.	Epoprostenol	119-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-110
16395396-5	2006	However, the concept of simply tipping a "balance" between COX-2-derived PGI2 and COX-1-derived platelet thromboxane is misplaced.	Epoprostenol	73-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-64
16395396-6	2006	Among the questions that remain to be addressed are the following: (a) whether this hazard extends to all or some of the traditional NSAIDs; (b) whether adjuvant therapies, such as low-dose aspirin, will mitigate the hazard and if so, at what cost; (c) whether COX-2 inhibitors result in cardiovascular risk transformation during chronic dosing; and (d) how we might identify individuals most likely to benefit or suffer from such drugs in the future.	Aspirin	190-197	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	261-266
16775385-1	2006	Cyclooxygenase (COX)-2, a rate-limiting enzyme for prostanoid synthesis, can be involved in inflammatory-mediated cytotoxicity.	Prostaglandins	51-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-22
16599250-3	2006	OBJECTIVE: To assess the safety of rofecoxib, a selective COX-2 inhibitor, in ASA/NSAID-intolerant patients.	rofecoxib	35-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
16775385-7	2006	Tat-induced COX-2 expression was partially prevented by pyrrolidine dithiocarbamate, a potent antioxidant and an inhibitor of the transcription factor, nuclear factor kappaB.	pyrrolidine dithiocarbamic acid	56-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-17
16775385-8	2006	Most importantly, administration of the COX-2 inhibitor NS-398 attenuated Tat-mediated upregulation of mRNA and protein expression of inflammatory mediators, such as monocyte chemoattractant protein-1, interleukin-1beta, tumor necrosis factor-alpha, and inducible nitric oxide synthase.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	56-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
17016062-0	2006	New evidence of H1-receptor independent COX-2 inhibition by fexofenadine HCl in vitro.	fexofenadine	60-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
17154669-6	2006	Preferential COX-2 inhibitors (nimesulide, meloxicam) are tolerated by the majority but not all hypersensitive patients.	nimesulide	31-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
17154669-6	2006	Preferential COX-2 inhibitors (nimesulide, meloxicam) are tolerated by the majority but not all hypersensitive patients.	Meloxicam	43-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
17154669-7	2006	Selective COX-2 inhibitors (celecoxib and rofecoxib [withdrawn from the market]) are well tolerated by almost all aspirin-sensitive asthmatic patients.	Celecoxib	28-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
17154669-7	2006	Selective COX-2 inhibitors (celecoxib and rofecoxib [withdrawn from the market]) are well tolerated by almost all aspirin-sensitive asthmatic patients.	rofecoxib	42-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
17154669-7	2006	Selective COX-2 inhibitors (celecoxib and rofecoxib [withdrawn from the market]) are well tolerated by almost all aspirin-sensitive asthmatic patients.	Aspirin	114-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
16581241-9	2006	The presence of a Co(II)-hydroxide-like phase Co(OH)2 and/or Co-Al layered double hydroxide (Co-Al LDH) or Co-phyllosilicate was observed.	Carbonic Acid	46-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-24
16581241-10	2006	Surprisingly, some of the initial Co(II) was partially oxidized and incorporated into a Co(III)O(OH)-like phase or a Co-phyllomanganate.	co(iii)o(oh)	88-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-40
16581241-10	2006	Surprisingly, some of the initial Co(II) was partially oxidized and incorporated into a Co(III)O(OH)-like phase or a Co-phyllomanganate.	co-phyllomanganate	117-135	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-40
16083427-3	2005	SCO2 is a copper-binding protein presumably involved in formation of the Cu(A) centre of the COX2 subunit.	Copper	10-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-97
16140261-2	2005	Recent evidence suggests that lineage-specific terminal prostanoid synthases, including prostaglandin (PG) E2, PGD2, PGF2alpha, PGI2, and thromboxane synthases, show distinct functional coupling with upstream COX isozymes, COX-1 and COX-2.	Dinoprostone	88-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	233-238
16140261-2	2005	Recent evidence suggests that lineage-specific terminal prostanoid synthases, including prostaglandin (PG) E2, PGD2, PGF2alpha, PGI2, and thromboxane synthases, show distinct functional coupling with upstream COX isozymes, COX-1 and COX-2.	Dinoprost	117-126	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	233-238
16140261-2	2005	Recent evidence suggests that lineage-specific terminal prostanoid synthases, including prostaglandin (PG) E2, PGD2, PGF2alpha, PGI2, and thromboxane synthases, show distinct functional coupling with upstream COX isozymes, COX-1 and COX-2.	Epoprostenol	128-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	233-238
16297351-12	2005	The IC50 values for the effect of celecoxib, PC-406 and PC-407 on COX-2 were 4.8, 8.9, and 1.9 nmol/L respectively.	Celecoxib	34-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-71
16297351-12	2005	The IC50 values for the effect of celecoxib, PC-406 and PC-407 on COX-2 were 4.8, 8.9, and 1.9 nmol/L respectively.	PC 406	45-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-71
16297351-12	2005	The IC50 values for the effect of celecoxib, PC-406 and PC-407 on COX-2 were 4.8, 8.9, and 1.9 nmol/L respectively.	4-(5-naphthyl-3- (trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide	56-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-71
16297351-13	2005	The IC(50, COX-1)/IC(50,COX-2) ratios for celecoxib and PC-407 were 8.3 and 14.4, respec-tively.	Celecoxib	42-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
16297351-13	2005	The IC(50, COX-1)/IC(50,COX-2) ratios for celecoxib and PC-407 were 8.3 and 14.4, respec-tively.	4-(5-naphthyl-3- (trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide	56-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
16297351-15	2005	CONCLUSION: Derivatives of celecoxib via substitution with an isopropyl or naphthyl group at the 5 position in the pyrazole ring still have analgesic effects and the ability to selectively inhibit COX-2.	Celecoxib	27-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	197-202
16297351-15	2005	CONCLUSION: Derivatives of celecoxib via substitution with an isopropyl or naphthyl group at the 5 position in the pyrazole ring still have analgesic effects and the ability to selectively inhibit COX-2.	pyrazole	115-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	197-202
16361154-2	2005	METHODS: Tissue microarray and immunohistochemistry by SABC method was employed for detecting COX-2 expression in 126 patients with advanced colorectal cancer, and the relationship of COX-2 expression with the clinicopathological features and prognosis of the patients was retrospectively analyzed.	sabc	55-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-99
16225966-1	2005	In this paper, the binding mode of original pyridinic compounds structurally related to nimesulide, a preferential cyclooxygenase (COX)-2 inhibitor, is analyzed by docking simulations in order to understand structure-activity relationships of this family.	nimesulide	88-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-137
16863437-5	2005	At the FDA-recommended doses meloxicam is COX-2 preferential.	Meloxicam	29-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47
16518289-1	2005	Drug-induced liver injury due to celecoxib, a first generation Cox-2 inhibitor, has been rarely reported.	Celecoxib	33-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-68
16354411-7	2005	Dexamethasone (100 nM) not only inhibited PGE2, PGF(2alpha), IL-6 and IL-8 production but also strongly suppressed the expression of COX-2 mRNA and protein.	Dexamethasone	0-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	133-138
16354411-8	2005	Licochalcone A had no effect on COX-1-dependent PGE2 production, whereas indometacin (100 nM), a dual inhibitor of COX-1 and COX-2, was very effective.	Indomethacin	73-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-130
16354411-9	2005	These results suggest that licochalcone A induces an anti-inflammatory effect through the inhibition of COX-2-dependent PGE2 production.	licochalcone A	27-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
16354411-9	2005	These results suggest that licochalcone A induces an anti-inflammatory effect through the inhibition of COX-2-dependent PGE2 production.	Dinoprostone	120-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
16195339-2	2005	Here, we show that proteasome inhibitors MG132, PSI-1, and lactacystin induce COX-2 expression via enhancing gene transcription rather than preventing protein degradation in the human alveolar NCI-H292 and A549, and gastric AGS epithelial cells.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	41-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-83
16195339-2	2005	Here, we show that proteasome inhibitors MG132, PSI-1, and lactacystin induce COX-2 expression via enhancing gene transcription rather than preventing protein degradation in the human alveolar NCI-H292 and A549, and gastric AGS epithelial cells.	lactacystin	59-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-83
16195339-6	2005	MG132-induced DNA-binding activity of C/EBPdelta, but not C/EBPbeta was regulated by p38, PI3K, Src, and protein kinase C. Small interfering RNA of C/EBPdelta suppressed COX-2 expression, further strengthening the role of C/EBPdelta in COX-2 gene transcription.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	0-5	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	170-175
16195339-6	2005	MG132-induced DNA-binding activity of C/EBPdelta, but not C/EBPbeta was regulated by p38, PI3K, Src, and protein kinase C. Small interfering RNA of C/EBPdelta suppressed COX-2 expression, further strengthening the role of C/EBPdelta in COX-2 gene transcription.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	0-5	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	236-241
16373709-11	2005	Significant down-regulation of COX-2 and EGFR expression was observed in the BxPC-3 and HPAC cells treated with the combination of erlotinib (1 micromol/L) and celecoxib (10 micromol/L) compared with celecoxib- or erlotinib-treated cells.	Erlotinib Hydrochloride	131-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-36
16373709-11	2005	Significant down-regulation of COX-2 and EGFR expression was observed in the BxPC-3 and HPAC cells treated with the combination of erlotinib (1 micromol/L) and celecoxib (10 micromol/L) compared with celecoxib- or erlotinib-treated cells.	Celecoxib	160-169	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-36
16373709-11	2005	Significant down-regulation of COX-2 and EGFR expression was observed in the BxPC-3 and HPAC cells treated with the combination of erlotinib (1 micromol/L) and celecoxib (10 micromol/L) compared with celecoxib- or erlotinib-treated cells.	Celecoxib	200-209	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-36
16373709-11	2005	Significant down-regulation of COX-2 and EGFR expression was observed in the BxPC-3 and HPAC cells treated with the combination of erlotinib (1 micromol/L) and celecoxib (10 micromol/L) compared with celecoxib- or erlotinib-treated cells.	Erlotinib Hydrochloride	214-223	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-36
16373709-14	2005	(a) Celecoxib can potentiate erlotinib-induced growth inhibition and apoptosis in pancreatic cell lines, (b) high baseline EGFR expression is a predictor of this potentiation, and (c) the down-regulation of EGFR, COX-2, and HER-2/neu expression and NF-kappaB inactivation contributes to the potentiation of erlotinib by celecoxib.	Erlotinib Hydrochloride	29-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	213-218
16169124-3	2005	Classical NSAIDs like indomethacin inhibit both the constitutive COX-1 and the inducible COX-2 enzymes.	Indomethacin	22-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-94
16169124-4	2005	In the present work, we characterize the protective effect of the indomethacin on the neurotoxicity elicited by amyloid-beta protein (A beta, fragments 25-35 and 1-42) alone or in combination with AA added exogenously as well as its effects on COX-2 expression.	Indomethacin	66-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	244-249
16198098-4	2005	Cells were pre-incubated in some experiments with the unselective COX inhibitor indomethacin or the COX-2 specific blocker NS-398.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	123-129	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-105
16213697-4	2005	In this study, using reference COX-2, 5-LOX and dual COX-2/5-LOX inhibitors, we devised a protocol which permitted the simultaneous quantification of eicosanoid metabolites formed during stimulation of human peripheral venous blood samples with the calcium ionophore, A23187, in the absence and presence of lipopolysaccharide (LPS).	Eicosanoids	150-160	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-58
15951234-2	2005	Ternary Fe(III), Co(II), Ni(II), Cu(II), Zn(II) and UO2(II) complexes with piroxicam (Pir) drug (H2L1) and dl-alanine (Ala) (HL2) and also the binary UO2(II) complex with Pir were studied.	Piroxicam	75-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-23
15951234-2	2005	Ternary Fe(III), Co(II), Ni(II), Cu(II), Zn(II) and UO2(II) complexes with piroxicam (Pir) drug (H2L1) and dl-alanine (Ala) (HL2) and also the binary UO2(II) complex with Pir were studied.	DL-ALANINE	107-117	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-23
15955728-4	2005	The molar conductance data reveal that Fe(III) and Co(II), Ni(II) and UO2(II) chelates are ionic in nature and are of the type 3:1 and 2:1 electrolytes, respectively, while Cu(II) and Zn(II) complexes are non-electrolytes.	uo2(ii)	70-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-57
15955728-4	2005	The molar conductance data reveal that Fe(III) and Co(II), Ni(II) and UO2(II) chelates are ionic in nature and are of the type 3:1 and 2:1 electrolytes, respectively, while Cu(II) and Zn(II) complexes are non-electrolytes.	cu(ii)	173-179	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-57
15955728-4	2005	The molar conductance data reveal that Fe(III) and Co(II), Ni(II) and UO2(II) chelates are ionic in nature and are of the type 3:1 and 2:1 electrolytes, respectively, while Cu(II) and Zn(II) complexes are non-electrolytes.	Zinc	184-190	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-57
16112603-3	2005	The molar conductance measurements of the complexes in DMF correspond to be nonelectrolytic nature for Mn(II), Co(II) and Cu(II) while 1:2 electrolytes for Ni(II) complexes.	Dimethylformamide	55-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	111-117
16112603-5	2005	On the basis of IR, electronic and EPR spectral studies an octahedral geometry has been assigned for Mn(II) and Co(II) complexes, square-planar for Ni(II) whereas tetragonal for Cu(II) complexes.	Nickel(2+)	148-154	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-118
16112603-5	2005	On the basis of IR, electronic and EPR spectral studies an octahedral geometry has been assigned for Mn(II) and Co(II) complexes, square-planar for Ni(II) whereas tetragonal for Cu(II) complexes.	cu(ii)	178-184	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-118
16296858-4	2005	The compounds are all reduced in multiple one-electron-transfer steps, the first of which involves the M(III)/M(II) process of the porphyrin in the case of (PCY)MClCoCl and the Co(III)/Co(II) process of the corrole in the case of (PCY)H2Co.	Porphyrins	131-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	177-182
16296858-8	2005	A reversible Co(III)/Co(II) reaction is seen for (PCB)MnClCoCl at -0.62 V, which when combined with spectroscopic data, leads to the assignment of (PCB)Mn(III)(py)2Co(III)(py) as the species in pyridine.	pyridine	194-202	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-27
16296861-2	2005	In the photostationary state of these four complexes, nearly 50% of the trans-azobenzene moieties of the Co(II) complexes were converted to the cis isomer, and nearly 10% of the trans-azobenzene moieties of the Co(III) complexes isomerized to the cis isomer, implying that the cis isomer ratio in the photostationary state upon irradiation at 365 nm is controlled not by the number of azobenzene moieties in one molecule but rather by the oxidation state of the cobalt ions.	azobenzene	72-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-111
16296861-2	2005	In the photostationary state of these four complexes, nearly 50% of the trans-azobenzene moieties of the Co(II) complexes were converted to the cis isomer, and nearly 10% of the trans-azobenzene moieties of the Co(III) complexes isomerized to the cis isomer, implying that the cis isomer ratio in the photostationary state upon irradiation at 365 nm is controlled not by the number of azobenzene moieties in one molecule but rather by the oxidation state of the cobalt ions.	azobenzene	78-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-111
16296861-2	2005	In the photostationary state of these four complexes, nearly 50% of the trans-azobenzene moieties of the Co(II) complexes were converted to the cis isomer, and nearly 10% of the trans-azobenzene moieties of the Co(III) complexes isomerized to the cis isomer, implying that the cis isomer ratio in the photostationary state upon irradiation at 365 nm is controlled not by the number of azobenzene moieties in one molecule but rather by the oxidation state of the cobalt ions.	azobenzene	184-194	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-111
16296861-2	2005	In the photostationary state of these four complexes, nearly 50% of the trans-azobenzene moieties of the Co(II) complexes were converted to the cis isomer, and nearly 10% of the trans-azobenzene moieties of the Co(III) complexes isomerized to the cis isomer, implying that the cis isomer ratio in the photostationary state upon irradiation at 365 nm is controlled not by the number of azobenzene moieties in one molecule but rather by the oxidation state of the cobalt ions.	Cobalt	462-468	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-111
16296861-3	2005	The femtosecond transient absorption spectra of the ligands and the complexes suggested that the photoexcited states of the azobenzene moieties in the Co(III) complexes were strongly deactivated by electron transfer from the azobenzene moiety to the cobalt center to form an azobenzene radical cation and a Co(II) center.	azobenzene	124-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	307-313
16296861-3	2005	The femtosecond transient absorption spectra of the ligands and the complexes suggested that the photoexcited states of the azobenzene moieties in the Co(III) complexes were strongly deactivated by electron transfer from the azobenzene moiety to the cobalt center to form an azobenzene radical cation and a Co(II) center.	azobenzene	225-235	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	307-313
16296861-3	2005	The femtosecond transient absorption spectra of the ligands and the complexes suggested that the photoexcited states of the azobenzene moieties in the Co(III) complexes were strongly deactivated by electron transfer from the azobenzene moiety to the cobalt center to form an azobenzene radical cation and a Co(II) center.	Cobalt	250-256	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	307-313
16296861-3	2005	The femtosecond transient absorption spectra of the ligands and the complexes suggested that the photoexcited states of the azobenzene moieties in the Co(III) complexes were strongly deactivated by electron transfer from the azobenzene moiety to the cobalt center to form an azobenzene radical cation and a Co(II) center.	azobenzene	225-235	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	307-313
16296861-4	2005	The cooperation among the photochemical structural changes of six azobenzene moieties in [Co(II)(dmAB)3](BF4)2 was investigated with 1H NMR spectroscopy.	azobenzene	66-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-96
16296861-4	2005	The cooperation among the photochemical structural changes of six azobenzene moieties in [Co(II)(dmAB)3](BF4)2 was investigated with 1H NMR spectroscopy.	Hydrogen	133-135	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-96
16296861-5	2005	The time-course change in the 1H NMR signals of the methyl protons indicated that each azobenzene moiety in [Co(II)(dmAB)3](BF4)2 isomerized to a cis isomer with a random probability of 50% and without interactions among the azobenzene moieties.	Hydrogen	30-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-115
16296861-5	2005	The time-course change in the 1H NMR signals of the methyl protons indicated that each azobenzene moiety in [Co(II)(dmAB)3](BF4)2 isomerized to a cis isomer with a random probability of 50% and without interactions among the azobenzene moieties.	azobenzene	87-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-115
16296861-5	2005	The time-course change in the 1H NMR signals of the methyl protons indicated that each azobenzene moiety in [Co(II)(dmAB)3](BF4)2 isomerized to a cis isomer with a random probability of 50% and without interactions among the azobenzene moieties.	azobenzene	225-235	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-115
16311613-1	2005	OBJECTIVE: To determine the risk of serious cardiovascular events associated with the use of the COX-2 inhibitor valdecoxib and its prodrug parecoxib following major surgery.	valdecoxib	113-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
16261231-1	2005	A SOD-like activity evaluated by a modified McCord-Fridovich test was evidenced for two Co(II) complexes built from "glycoligands" using a sugar platform derived from d-galactose and D-galactal and functionalized by three 2-picolyl groups.	Sugars	139-144	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-94
16261231-1	2005	A SOD-like activity evaluated by a modified McCord-Fridovich test was evidenced for two Co(II) complexes built from "glycoligands" using a sugar platform derived from d-galactose and D-galactal and functionalized by three 2-picolyl groups.	Galactose	167-178	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-94
16084726-2	2005	Diarylheptylamine 12b and diarylheptanoid analogs can inhibit iNOS and COX-2 responses of LPS, although less potently than 1.	diarylheptylamine 12b	0-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-76
16084726-2	2005	Diarylheptylamine 12b and diarylheptanoid analogs can inhibit iNOS and COX-2 responses of LPS, although less potently than 1.	Diarylheptanoids	26-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-76
16084726-3	2005	These compounds, however, possess stronger potency than 1 against COX-2-derived PGE2 formation, of which hexahydrocurcumin (4) is the most potent one with an IC50 value of 0.7 microM.	Dinoprostone	80-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-71
16084726-3	2005	These compounds, however, possess stronger potency than 1 against COX-2-derived PGE2 formation, of which hexahydrocurcumin (4) is the most potent one with an IC50 value of 0.7 microM.	hexahydrocurcumin	105-122	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-71
16212933-5	2005	Electron paramagnetic resonance spectroscopic spin counting analysis of proteoliposomes formed with nitroxide spin-labeled COX-2 gave a nearly identical phospholipid:COX ratio, confirming that incorporation had no effect on enzyme activity, and demonstrating that the efficiency of protein incorporation is sufficient for EPR spectroscopic analysis.	Hydroxylamine	100-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-128
16212933-5	2005	Electron paramagnetic resonance spectroscopic spin counting analysis of proteoliposomes formed with nitroxide spin-labeled COX-2 gave a nearly identical phospholipid:COX ratio, confirming that incorporation had no effect on enzyme activity, and demonstrating that the efficiency of protein incorporation is sufficient for EPR spectroscopic analysis.	Phospholipids	153-165	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-128
16270978-0	2005	Hexacyanocobaltate(III) anions as precursors of Co(II)-Ni(II) cyano-bridged multidimensional assemblies: hydrothermal syntheses, crystal and powder X-ray structures, and magnetic properties.	hexacyanocobaltate	0-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-54
16270978-3	2005	Compound 3 contains one-dimensional zigzag chains in which the Co(II) ion is coordinated by two chelating 2,2"-bipy ligands and two cyanides from two different [Ni(CN)4]2- units cis to each other.	2,2"-bipy	106-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-69
16270978-3	2005	Compound 3 contains one-dimensional zigzag chains in which the Co(II) ion is coordinated by two chelating 2,2"-bipy ligands and two cyanides from two different [Ni(CN)4]2- units cis to each other.	Cyanides	132-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-69
16228044-0	2005	Unique self-assembled 2D metal-tetrazolate networks: crystal structure and magnetic properties of [M(pmtz)2](M = Co(II) and Fe(II); Hpmtz = 5-(pyrimidyl)tetrazole).	metal-tetrazolate	25-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-119
16228044-0	2005	Unique self-assembled 2D metal-tetrazolate networks: crystal structure and magnetic properties of [M(pmtz)2](M = Co(II) and Fe(II); Hpmtz = 5-(pyrimidyl)tetrazole).	[m(pmtz)2	98-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-119
16317895-1	2005	The spectrophotometric titration of cobalt(II) with CaCl2 was carried out in mixed solvents of 2-propanol and water at different solvent compositions of 2-propannol, water and CaCl2 to analyze the salting-out extraction mechanism of Co(II) by the addition of CaCl2 from the mixed solvents.	Cobalt(2+)	36-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	233-239
16317895-1	2005	The spectrophotometric titration of cobalt(II) with CaCl2 was carried out in mixed solvents of 2-propanol and water at different solvent compositions of 2-propannol, water and CaCl2 to analyze the salting-out extraction mechanism of Co(II) by the addition of CaCl2 from the mixed solvents.	Calcium Chloride	52-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	233-239
16358608-8	2005	A transient elevation of c-Fos and c-Jun messenger RNAs was induced by TNF-alpha, whereas COX-2 inhibitors NS-398 and meloxicam abolished the up-regulation of c-Fos.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	107-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-95
16358608-8	2005	A transient elevation of c-Fos and c-Jun messenger RNAs was induced by TNF-alpha, whereas COX-2 inhibitors NS-398 and meloxicam abolished the up-regulation of c-Fos.	Meloxicam	118-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-95
16336399-7	2005	Aspirin dose-dependently decreased the levels of COX-2 mRNA, COX-2 protein and nuclear NF-kappaB protein and increased the cytoplasmic IkappaB protein.	Aspirin	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-54
16336399-7	2005	Aspirin dose-dependently decreased the levels of COX-2 mRNA, COX-2 protein and nuclear NF-kappaB protein and increased the cytoplasmic IkappaB protein.	Aspirin	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-66
16255020-8	2005	The addition of either TNF blockers or dexamethasone suppressed lipopolysaccharide-induced mPGES-1 and COX-2 expression in synovial fluid monocyte/macrophages in vitro and decreased the production of PGE(2).	Dexamethasone	39-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-108
16143531-1	2005	A new class of 1,3-diphenylprop-2-yn-1-ones possessing a p-MeSO2 COX-2 phamacophore on the C-3 phenyl ring was designed for evaluation as dual inhibitors of cyclooxygenase (COX) and lipoxygenase (LOX).	1,3-diphenylprop-2-yn-1-ones	15-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-70
16143531-1	2005	A new class of 1,3-diphenylprop-2-yn-1-ones possessing a p-MeSO2 COX-2 phamacophore on the C-3 phenyl ring was designed for evaluation as dual inhibitors of cyclooxygenase (COX) and lipoxygenase (LOX).	p-meso2	57-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-70
17191953-8	2005	ASP Analysis of human COX proteins suggests that some specificity determinants that distinguish COX-1 and COX-2 proteins are similar between sheep COX-1/mouse COX-2 and human COX-1/COX2; however, residue identities at those positions are not necessarily conserved.	Aspartic Acid	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-111
16081631-4	2005	We investigated a role for PGF2alpha-FP receptor interaction in modulating COX-2 expression and PGF2alpha biosynthesis using an endometrial adenocarcinoma cell line stably transfected with the FP receptor cDNA (FPS cells).	Dinoprost	27-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
16081631-6	2005	These effects of PGF2alpha on the expression of COX-2 could be abolished by treatment of FPS cells with an FP receptor antagonist (AL8810) and chemical inhibitor of ERK1/2 kinase (PD98059), or by inactivation of ERK1/2 signaling with dominant-negative mutant isoforms of Ras or ERK1/2 kinase.	Dinoprost	17-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-53
16081631-6	2005	These effects of PGF2alpha on the expression of COX-2 could be abolished by treatment of FPS cells with an FP receptor antagonist (AL8810) and chemical inhibitor of ERK1/2 kinase (PD98059), or by inactivation of ERK1/2 signaling with dominant-negative mutant isoforms of Ras or ERK1/2 kinase.	AL 8810	131-137	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-53
16081631-6	2005	These effects of PGF2alpha on the expression of COX-2 could be abolished by treatment of FPS cells with an FP receptor antagonist (AL8810) and chemical inhibitor of ERK1/2 kinase (PD98059), or by inactivation of ERK1/2 signaling with dominant-negative mutant isoforms of Ras or ERK1/2 kinase.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	180-187	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-53
16081631-7	2005	We further confirmed that elevated COX-2 protein in FPS cells could biosynthesize PGF2alpha de novo to promote a positive feedback loop to facilitate endometrial tumorigenesis.	Dinoprost	82-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40
16081631-8	2005	Finally, we have shown that PGF2alpha could potentiate tumorigenesis in endometrial adenocarcinoma explants by inducing the expression of COX-2 mRNA.	Dinoprost	28-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	138-143
16255660-4	2005	Celecoxib was the first COX-2 inhibitor introduced and the only remaining one on the US market.	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
16227351-2	2005	Selective COX-2 inhibitors were seen as successor to non-selective non-steroidal anti-inflammatory drugs, in turn successors to aspirin.	Aspirin	128-135	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
16275389-10	2005	The COX-2 inhibitor NS398 counteracted the effects of IL-17, and prostaglandin E(2) prevented counteraction by NS398.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	20-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
16308480-5	2005	While total RNA yield and abundance were not significantly altered, both iron and aluminum were found to induce HSP27, COX-2, betaAPP and DAXX gene expression.	Iron	73-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-124
16308480-5	2005	While total RNA yield and abundance were not significantly altered, both iron and aluminum were found to induce HSP27, COX-2, betaAPP and DAXX gene expression.	Aluminum	82-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-124
16328700-4	2005	Under the optimal conditions, the luminescence intensity of (Co-DDTC)( n ) chelate complex nanoparticles at 470 nm (F (470 nm)) is linear to Co(II) concentration in the range of 0.012-1.44 microg/mL.	co-ddtc	61-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	141-147
16046614-5	2005	Both inhibitors decreased basal production of prostacyclin, but only COX-2 inhibition completely abolished the isoflavone-stimulated prostacyclin production.	Isoflavones	111-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-74
16046614-5	2005	Both inhibitors decreased basal production of prostacyclin, but only COX-2 inhibition completely abolished the isoflavone-stimulated prostacyclin production.	Epoprostenol	133-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-74
16046614-8	2005	The results clearly support the hypothesis that genistein and daidzein increased HUVEC prostacyclin production through estrogen receptor-dependent mechanism, which involved the enhancement of COX-2 protein and activity.	Epoprostenol	87-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	192-197
16120814-9	2005	We conclude that PAR(2)-triggered PGE(2) formation in A549 cells involves a coordinated up-regulation of COX-2 and mPGES-1 involving cPLA(2), increased cytosolic Ca(2+), PKC, Src, MEK-ERK, p38 MAPK, Src-mediated EGF receptor trans-activation, and also metabolic products of both COX-1 and COX-2.	Dinoprostone	34-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-110
16120814-9	2005	We conclude that PAR(2)-triggered PGE(2) formation in A549 cells involves a coordinated up-regulation of COX-2 and mPGES-1 involving cPLA(2), increased cytosolic Ca(2+), PKC, Src, MEK-ERK, p38 MAPK, Src-mediated EGF receptor trans-activation, and also metabolic products of both COX-1 and COX-2.	Dinoprostone	34-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	289-294
16112608-0	2005	Synthesis, spectral and thermal studies of Co(II), Ni(II) and Cu(II) complexes 1-(4,6-dimethyl-pyrimidin-2-ylazo)-naphthalen-2-ol.	cu(ii)	62-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-49
16112608-0	2005	Synthesis, spectral and thermal studies of Co(II), Ni(II) and Cu(II) complexes 1-(4,6-dimethyl-pyrimidin-2-ylazo)-naphthalen-2-ol.	1-(4,6-dimethylpyrimidin-2-ylazo)naphthalen-2-ol	79-129	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-49
16112608-5	2005	Novel complexes of Co(II), Ni(II) and Cu(II) with the pyrimidine azodye have been synthesized and characterized on the basis of elemental analyses, molar conductance, magnetic susceptibility measurements, IR, electronic as well as ESR spectral studies The thermal decomposition of the metal complexes is studied by TGA and DTA techniques.	pyrimidine azodye	54-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-25
16112608-5	2005	Novel complexes of Co(II), Ni(II) and Cu(II) with the pyrimidine azodye have been synthesized and characterized on the basis of elemental analyses, molar conductance, magnetic susceptibility measurements, IR, electronic as well as ESR spectral studies The thermal decomposition of the metal complexes is studied by TGA and DTA techniques.	Metals	285-290	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-25
16112608-5	2005	Novel complexes of Co(II), Ni(II) and Cu(II) with the pyrimidine azodye have been synthesized and characterized on the basis of elemental analyses, molar conductance, magnetic susceptibility measurements, IR, electronic as well as ESR spectral studies The thermal decomposition of the metal complexes is studied by TGA and DTA techniques.	deoxythymidylyl-3'-5'-deoxyadenylate	323-326	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-25
16257758-2	2005	Hexa-aza-macrocycles containing glutarimide efficiently coordinate as hexa-dentate ligand, to give complexes of Cu(II) possessing tetragonal structure and Mn(II), Co(II) and Ni(II) metal ions that are essentially octahedral.	glutarimide	32-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	163-169
16257758-2	2005	Hexa-aza-macrocycles containing glutarimide efficiently coordinate as hexa-dentate ligand, to give complexes of Cu(II) possessing tetragonal structure and Mn(II), Co(II) and Ni(II) metal ions that are essentially octahedral.	cu(ii)	112-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	163-169
16440987-1	2006	The synthesis of transition metal barbiturate, and thiobarbiturate complexes containing different functional groups of variable electronic character with CoII, NiII, CuII, PdII, and PtII have been prepared.	metal barbiturate	28-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	154-158
16440987-1	2006	The synthesis of transition metal barbiturate, and thiobarbiturate complexes containing different functional groups of variable electronic character with CoII, NiII, CuII, PdII, and PtII have been prepared.	thiobarbituric acid	51-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	154-158
17016062-5	2006	COX-2 enzyme inhibitory activity for the antihistamines was compared with the known selective COX-2 inhibitor DuP-679.	dup-679	110-117	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-99
17016062-8	2006	The inhibition of COX-2 activity by FEX was similar to that seen with the selective COX-2 inhibitor, DuP-679.	fexofenadine	36-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-23
17016062-8	2006	The inhibition of COX-2 activity by FEX was similar to that seen with the selective COX-2 inhibitor, DuP-679.	dup-679	101-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-89
17016062-11	2006	CONCLUSION: FEX showed selective arachidonic acid-mediated COX-2 inhibitory enzyme activity, which differed markedly from the COX inhibitory enzyme activity of LOR.	fexofenadine	12-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-64
17016062-11	2006	CONCLUSION: FEX showed selective arachidonic acid-mediated COX-2 inhibitory enzyme activity, which differed markedly from the COX inhibitory enzyme activity of LOR.	Arachidonic Acid	33-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-64
17016062-12	2006	This selective COX-2 inhibitor activity by FEX may contribute to its anti-inflammatory properties in relieving nasal congestion in allergic rhinitis.	fexofenadine	43-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-20
16337272-3	2006	NSAIDs inhibit cyclooxygenase-1 (COX-1) and/or cyclooxygenase-2 (COX-2) activity and considerable evidence supports a role for prostaglandins in cancer development.	Prostaglandins	127-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-70
16423197-5	2006	SB203580 and H-7, but not PD098059, inhibited IL-1beta-induced expression of COX-2 protein.	SB 203580	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-82
16363839-1	2005	A detailed study of the electronic structure of seven-coordinate Mn(II), Co(II), and Ni(II) complexes with the lariat ether N,N"-bis(2-aminobenzyl)-1,10-diaza-15-crown-5 (L(1)) is presented.	lariat ether n,n"-bis(2-aminobenzyl)-1,10-diaza-15-crown-5	111-169	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-79
16363839-3	2005	The X-ray crystal structures of the Mn(II) and Co(II) complexes show C(2) symmetries for the [M(L(1))](2+) cations, whereas the structures of the Ni(II) complexes show a more distorted coordination environment.	Nickel(2+)	146-152	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-53
16363839-6	2005	Electronic structure calculations predict a similar ordering of the metal-based beta spin frontier MO for the Mn(II) and Co(II) complexes.	Metals	68-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-127
16363839-9	2005	Our electronic structure calculations predict that the binding strength of L(1) should follow the trend Co(II) approximately Mn(II) &gt; Ni(II), in agreement with experimental data obtained from spectrophotometric titrations.	Manganese(2+)	125-131	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-110
16363839-9	2005	Our electronic structure calculations predict that the binding strength of L(1) should follow the trend Co(II) approximately Mn(II) &gt; Ni(II), in agreement with experimental data obtained from spectrophotometric titrations.	Nickel(2+)	137-143	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-110
16363841-3	2005	The Co(II) compound is isostructural to the Fe(II) compound.	ammonium ferrous sulfate	44-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
16157291-4	2005	These results suggest that PGF synthesized through COX-1 and PGF synthase plays an important physiological role in the kidney and that the expression of COX-2 in kidney is a useful maker for tumorigenesis of the renal call carcinoma in vivo.	Prostaglandins F	27-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	153-158
16165092-1	2005	Co(II), Ni(II), and N-oxalylglycine (NOG) are well-known inhibitors of Fe(II)/alpha-ketoglutarate (alphaKG)-dependent hydroxylases, but few studies describe their kinetics and no spectroscopic investigations have been reported.	oxalylglycine	37-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
16165092-1	2005	Co(II), Ni(II), and N-oxalylglycine (NOG) are well-known inhibitors of Fe(II)/alpha-ketoglutarate (alphaKG)-dependent hydroxylases, but few studies describe their kinetics and no spectroscopic investigations have been reported.	ammonium ferrous sulfate	71-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
16165092-3	2005	Whereas Ni(II)-substituted TauD was non-chromophoric, spectroscopic studies of the Co(II)-substituted enzyme revealed a six-coordinate site (protein alone or with alphaKG) that became five-coordinate upon taurine addition.	Taurine	205-212	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-89
16353278-1	2005	Novel 1,2-disubstituted imidazoles were synthesized and tested for COX-1 and COX-2 inhibition.	1,2-disubstituted imidazoles	6-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-82
16321158-1	2005	BACKGROUND: The aim of this study was to evaluate the long-term efficacy and tolerability of etoricoxib, a COX-2 selective inhibitor, in osteoarthritis (OA) patients.	Etoricoxib	93-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-112
16188503-6	2005	In some circumstances, COX-2 produces a highly potent gastroprotective substance (15-R-lipoxin A(4)), and analogues of this substance could have therapeutic value for preventing gastric ulceration.	15-r-lipoxin a	82-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-28
16354411-4	2005	NS-398 (IC50 1.6 nM), a COX-2 selective inhibitor, also suppressed the PGE2 production.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	0-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
16354411-4	2005	NS-398 (IC50 1.6 nM), a COX-2 selective inhibitor, also suppressed the PGE2 production.	Dinoprostone	71-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
16399783-1	2005	Human labour is associated with increased prostaglandin synthesis within the uterus by the action of the inducible type-2 cyclo-oxygenase enzyme (COX-2).	Prostaglandins	42-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	146-151
16399783-2	2005	A major source of prostaglandin is the fetal membranes, in particular the amnion, in which expression of COX-2 increases in late pregnancy and with labour.	Prostaglandins	18-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-110
16198098-8	2005	Both COX-1 and COX-2 affected the regulation of PGE(2) synthesis in MG-63 cells.	Dinoprostone	48-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-20
16563251-0	2005	[Atorvastatin reduces the expression of COX-2 mRNA in peripheral blood monocytes in patients with acute myocardial infarction and modulates the early inflammatory response].	Atorvastatin	1-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
16563251-1	2005	OBJECTIVE: To measure the effect of atorvastatin on COX-2 expression in monocytes in patients with acute myocardial infarction (AMI).	Atorvastatin	36-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-57
16563251-6	2005	RESULTS: COX-2 expression in monocytes in patients with AMI (0.92 +/- 0.13) was significantly higher than that in the control subjects (0.19 +/- 0.08), and decreased by 66% after atorvastatin (compared with that on routine therapy, P &lt; 0.05); IL-6 secretions of monocytes in the AMI group (204.8 +/- 45.6 ng/L) increased dramatically compared with those in the control group (40.9 +/- 1.2 ng/L, P &lt; 0.05), and reduced dramatically by 58% when incubated with 10 micromol/L celecoxib (P &lt; 0.05) in a concentration-dependent manner; plasma levels of CRP in the AMI group (43.3 +/- 14.9 mg/L) significantly increased compared with those in the control group (1.7 +/- 0.8 mg/L), and reduced by 62% after atorvastatin (compared with those in the routine therapy group, P &lt; 0.05).	Atorvastatin	179-191	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	9-14
16563251-6	2005	RESULTS: COX-2 expression in monocytes in patients with AMI (0.92 +/- 0.13) was significantly higher than that in the control subjects (0.19 +/- 0.08), and decreased by 66% after atorvastatin (compared with that on routine therapy, P &lt; 0.05); IL-6 secretions of monocytes in the AMI group (204.8 +/- 45.6 ng/L) increased dramatically compared with those in the control group (40.9 +/- 1.2 ng/L, P &lt; 0.05), and reduced dramatically by 58% when incubated with 10 micromol/L celecoxib (P &lt; 0.05) in a concentration-dependent manner; plasma levels of CRP in the AMI group (43.3 +/- 14.9 mg/L) significantly increased compared with those in the control group (1.7 +/- 0.8 mg/L), and reduced by 62% after atorvastatin (compared with those in the routine therapy group, P &lt; 0.05).	Celecoxib	478-487	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	9-14
16563251-6	2005	RESULTS: COX-2 expression in monocytes in patients with AMI (0.92 +/- 0.13) was significantly higher than that in the control subjects (0.19 +/- 0.08), and decreased by 66% after atorvastatin (compared with that on routine therapy, P &lt; 0.05); IL-6 secretions of monocytes in the AMI group (204.8 +/- 45.6 ng/L) increased dramatically compared with those in the control group (40.9 +/- 1.2 ng/L, P &lt; 0.05), and reduced dramatically by 58% when incubated with 10 micromol/L celecoxib (P &lt; 0.05) in a concentration-dependent manner; plasma levels of CRP in the AMI group (43.3 +/- 14.9 mg/L) significantly increased compared with those in the control group (1.7 +/- 0.8 mg/L), and reduced by 62% after atorvastatin (compared with those in the routine therapy group, P &lt; 0.05).	Atorvastatin	708-720	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	9-14
16563251-9	2005	Atorvastatin may decrease COX-2 expression in peripheral blood monocytes in patients with AMI and cyclooxygenase-dependent pathway might be correlated with the anti-inflammation mechanism of statin.	Atorvastatin	0-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-31
16220162-1	2005	A metal-organic open-framework with an unprecedented (6,3)-helical topology, large channels and mixed ferro- and antiferromagnetic interactions has been synthesized using a three-connecting tricarboxylic polychlorotriphenylmethyl radical and Co(ii) ions.	Metals	2-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	242-248
16212342-2	2005	The X-ray structure of 1 grown in dichloromethane shows square-pyramidal coordination around the Co(II) ion, displaying a 1D polymeric network.	Methylene Chloride	34-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-103
16212342-3	2005	When grown in chloroform, 1 displays an octahedral coordination around Co(II), resulting in a 2D coordination network.	Chloroform	14-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-77
16125137-3	2005	NFD-37 compound exhibited a preferred inhibition on enzyme activity of cyclooxygenase (COX)-2 over COX-1.	2-methyl-2-(2-methylpropenyl)-2,3-dihydronaphtho(2,3-b)furan-4,9-dione	0-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-93
16230415-0	2005	Radiosensitivity enhancement by celecoxib, a cyclooxygenase (COX)-2 selective inhibitor, via COX-2-dependent cell cycle regulation on human cancer cells expressing differential COX-2 levels.	Celecoxib	32-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-98
16230415-0	2005	Radiosensitivity enhancement by celecoxib, a cyclooxygenase (COX)-2 selective inhibitor, via COX-2-dependent cell cycle regulation on human cancer cells expressing differential COX-2 levels.	Celecoxib	32-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	177-182
16230415-5	2005	Celecoxib"s radiation-enhancing effect was observed in COX-2-expressing A549 and NCI-H460 cells but was not observed in the COX-2 nonexpressing MCF-7 and HCT-116 cells.	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-60
16230415-6	2005	Celecoxib"s radiation-enhancing effects in A549 cells were shown to disappear after the administration of COX-2 knocked down.	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-111
16230415-7	2005	In contrast, the HCT-116 cells were radiosensitized by celecoxib after being transfected with COX-2 expression vector.	Celecoxib	55-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-99
16230415-10	2005	Celecoxib or NS-398 effected no changes or attenuated radiation-induced G(2)-M arrest in the COX-2-overexpressing cells but further enhanced the radiation-induced G(2)-M arrest in the COX-2 low-expressing cells.	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	184-189
16230415-10	2005	Celecoxib or NS-398 effected no changes or attenuated radiation-induced G(2)-M arrest in the COX-2-overexpressing cells but further enhanced the radiation-induced G(2)-M arrest in the COX-2 low-expressing cells.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	13-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	184-189
16230415-11	2005	Celecoxib"s radiation-enhancing effects seem to occur in a COX-2 expression-dependent manner in the cancer cells.	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-64
16230415-13	2005	Celecoxib may exert an inhibitory effect on enhanced radiation-induced G2-M arrest in the COX-2-overexpressing cells, which may allow the arrested cells to enter mitosis and die after radiation, but may also further enhance radiation-induced G2-M arrest in the COX-2 low-expressing cells, by virtue of another mechanism.	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-95
16230415-13	2005	Celecoxib may exert an inhibitory effect on enhanced radiation-induced G2-M arrest in the COX-2-overexpressing cells, which may allow the arrested cells to enter mitosis and die after radiation, but may also further enhance radiation-induced G2-M arrest in the COX-2 low-expressing cells, by virtue of another mechanism.	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	261-266
16125137-4	2005	Further, NFD-37 compound attenuated LPS-induced synthesis of both mRNA and protein of COX-2, and suppressed LPS-induced COX-2 promoter activity in the macrophages, indicating that the furonaphthoquinone compound could down-regulate LPS-induced COX-2 expression at the transcription level.	furonaphthoquinone	184-202	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-91
16125137-4	2005	Further, NFD-37 compound attenuated LPS-induced synthesis of both mRNA and protein of COX-2, and suppressed LPS-induced COX-2 promoter activity in the macrophages, indicating that the furonaphthoquinone compound could down-regulate LPS-induced COX-2 expression at the transcription level.	furonaphthoquinone	184-202	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-125
16125137-4	2005	Further, NFD-37 compound attenuated LPS-induced synthesis of both mRNA and protein of COX-2, and suppressed LPS-induced COX-2 promoter activity in the macrophages, indicating that the furonaphthoquinone compound could down-regulate LPS-induced COX-2 expression at the transcription level.	furonaphthoquinone	184-202	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-125
16224508-1	2005	OBJECTIVE: To determine the risk of thromboembolic cardiovascular events associated with the use of etoricoxib, a COX-2 inhibitor.	Etoricoxib	100-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-119
16224508-11	2005	However, the limited data that were available provide weak evidence of an increased cardiovascular risk with etoricoxib consistent with a class effect for COX-2 inhibitors.	Etoricoxib	109-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	155-160
16180888-1	2005	Mononuclear Ni(II), Co(II), and Zn(II) complexes of the bppppa (N,N-bis[(6-phenyl-2-pyridyl)methyl]-N-[(6-pivaloylamido-2-pyridyl)methyl]amine) ligand have been synthesized and characterized by X-ray crystallography, 1H NMR, UV-vis (Ni(II) and Co(II)) and infrared spectroscopy, and elemental analysis.	Zinc	32-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	244-250
16180888-1	2005	Mononuclear Ni(II), Co(II), and Zn(II) complexes of the bppppa (N,N-bis[(6-phenyl-2-pyridyl)methyl]-N-[(6-pivaloylamido-2-pyridyl)methyl]amine) ligand have been synthesized and characterized by X-ray crystallography, 1H NMR, UV-vis (Ni(II) and Co(II)) and infrared spectroscopy, and elemental analysis.	bppppa	56-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-26
16180888-1	2005	Mononuclear Ni(II), Co(II), and Zn(II) complexes of the bppppa (N,N-bis[(6-phenyl-2-pyridyl)methyl]-N-[(6-pivaloylamido-2-pyridyl)methyl]amine) ligand have been synthesized and characterized by X-ray crystallography, 1H NMR, UV-vis (Ni(II) and Co(II)) and infrared spectroscopy, and elemental analysis.	bppppa	56-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	244-250
16180888-1	2005	Mononuclear Ni(II), Co(II), and Zn(II) complexes of the bppppa (N,N-bis[(6-phenyl-2-pyridyl)methyl]-N-[(6-pivaloylamido-2-pyridyl)methyl]amine) ligand have been synthesized and characterized by X-ray crystallography, 1H NMR, UV-vis (Ni(II) and Co(II)) and infrared spectroscopy, and elemental analysis.	(n,n-bis[(6-phenyl-2-pyridyl)methyl]-n-[(6-pivaloylamido-2-pyridyl)methyl]amine)	63-143	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-26
16180888-1	2005	Mononuclear Ni(II), Co(II), and Zn(II) complexes of the bppppa (N,N-bis[(6-phenyl-2-pyridyl)methyl]-N-[(6-pivaloylamido-2-pyridyl)methyl]amine) ligand have been synthesized and characterized by X-ray crystallography, 1H NMR, UV-vis (Ni(II) and Co(II)) and infrared spectroscopy, and elemental analysis.	(n,n-bis[(6-phenyl-2-pyridyl)methyl]-n-[(6-pivaloylamido-2-pyridyl)methyl]amine)	63-143	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	244-250
16507399-6	2005	Increased COX-2 activity has been associated with tumor growth, poor prognostic characteristics, and unfavorable clinical outcome; therefore, up-regulation of COX-2 might attenuate the anti-tumor effect of the taxanes.	Taxoids	210-217	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
16041399-4	2005	Transient gene expression assays using human cox-2 promoter construct revealed that ethyl caffeate exerted an inhibitory effect on cox-2 transcriptional activity in 12-O-tetradecanoylphorbol-13-acetate (TPA)-treated MCF-7 cells.	ethyl caffeate	84-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-50
16507399-6	2005	Increased COX-2 activity has been associated with tumor growth, poor prognostic characteristics, and unfavorable clinical outcome; therefore, up-regulation of COX-2 might attenuate the anti-tumor effect of the taxanes.	Taxoids	210-217	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	159-164
16041399-4	2005	Transient gene expression assays using human cox-2 promoter construct revealed that ethyl caffeate exerted an inhibitory effect on cox-2 transcriptional activity in 12-O-tetradecanoylphorbol-13-acetate (TPA)-treated MCF-7 cells.	ethyl caffeate	84-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-136
16507399-7	2005	This provides the rationale for the use of COX-2 inhibitors in combination with taxanes, as this could theoretically improve the clinical efficacy of paclitaxel and docetaxel.	Paclitaxel	150-160	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
16041399-4	2005	Transient gene expression assays using human cox-2 promoter construct revealed that ethyl caffeate exerted an inhibitory effect on cox-2 transcriptional activity in 12-O-tetradecanoylphorbol-13-acetate (TPA)-treated MCF-7 cells.	Tetradecanoylphorbol Acetate	165-201	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-50
16041399-4	2005	Transient gene expression assays using human cox-2 promoter construct revealed that ethyl caffeate exerted an inhibitory effect on cox-2 transcriptional activity in 12-O-tetradecanoylphorbol-13-acetate (TPA)-treated MCF-7 cells.	Tetradecanoylphorbol Acetate	165-201	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-136
16507399-7	2005	This provides the rationale for the use of COX-2 inhibitors in combination with taxanes, as this could theoretically improve the clinical efficacy of paclitaxel and docetaxel.	Docetaxel	165-174	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
16041399-4	2005	Transient gene expression assays using human cox-2 promoter construct revealed that ethyl caffeate exerted an inhibitory effect on cox-2 transcriptional activity in 12-O-tetradecanoylphorbol-13-acetate (TPA)-treated MCF-7 cells.	Tetradecanoylphorbol Acetate	203-206	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-136
16507399-8	2005	Results from preclinical studies have generally shown enhanced anticancer activity from the addition of COX-2 inhibitors to taxane treatment.	taxane	124-130	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
16507399-10	2005	There may also be a role for COX-2 inhibitors in ameliorating some of the side effects of taxane treatment, such as fatigue, myalgia, and arthralgia.	taxane	90-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34
16507399-11	2005	Randomized clinical trials would be needed to establish whether COX-2 inhibitors improve the therapeutic profile of docetaxel or paclitaxel in patients with solid tumors.	Docetaxel	116-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-69
16507399-11	2005	Randomized clinical trials would be needed to establish whether COX-2 inhibitors improve the therapeutic profile of docetaxel or paclitaxel in patients with solid tumors.	Paclitaxel	129-139	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-69
19956533-0	2005	Pattern of apoptosis by NS398, a selective COX-2 inhibitor, in hepatocellular carcinoma cell lines.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	24-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
15891886-5	2005	We now show that treatment of tumor cells with the nonselective COX-1/COX-2 inhibitor indomethacin or the selective COX-2 inhibitor celecoxib leads to decreased expression of the MHC class I molecules Ld and Kd .	Indomethacin	86-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-75
15891886-5	2005	We now show that treatment of tumor cells with the nonselective COX-1/COX-2 inhibitor indomethacin or the selective COX-2 inhibitor celecoxib leads to decreased expression of the MHC class I molecules Ld and Kd .	Celecoxib	132-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-121
16038795-3	2005	This transient activation of SPHK1 was found to be required for cytokine-induced COX-2 transcription and PGE2 production, since not only specific siRNA (abolishing both basal and induced SPHK1 enzyme activity), but also a dominant-negative SPHK1 mutant (suppressing induced SPHK1 activity only) both reduced COX-2 and PGE2.	Dinoprostone	105-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	308-313
16038795-3	2005	This transient activation of SPHK1 was found to be required for cytokine-induced COX-2 transcription and PGE2 production, since not only specific siRNA (abolishing both basal and induced SPHK1 enzyme activity), but also a dominant-negative SPHK1 mutant (suppressing induced SPHK1 activity only) both reduced COX-2 and PGE2.	Dinoprostone	318-322	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-86
19956533-1	2005	PURPOSE: NS398, a selective COX-2 inhibitor, is known to inhibit the growth of COX-2 expressing hepatocellular carcinoma cells.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	9-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
19956533-1	2005	PURPOSE: NS398, a selective COX-2 inhibitor, is known to inhibit the growth of COX-2 expressing hepatocellular carcinoma cells.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	9-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-84
16184416-1	2005	COX-1 and COX-2 are two cyclooxygenase enzymes responsible for prostanoid production.	Prostaglandins	63-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
16184416-3	2005	Aspirin induces and acetylates COX-2 to produce 15-(R)-epi-lipoxinA4, an anti-inflammatory mediator thought to protect the gastric mucosa against aspirin-induced injury.	Aspirin	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-36
16184416-3	2005	Aspirin induces and acetylates COX-2 to produce 15-(R)-epi-lipoxinA4, an anti-inflammatory mediator thought to protect the gastric mucosa against aspirin-induced injury.	15-(r)-epi-lipoxina4	48-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-36
16184416-3	2005	Aspirin induces and acetylates COX-2 to produce 15-(R)-epi-lipoxinA4, an anti-inflammatory mediator thought to protect the gastric mucosa against aspirin-induced injury.	Aspirin	146-153	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-36
16184416-4	2005	Recently, three different PGE synthases have been identified, that convert COX-2 metabolites into PGE2.	Prostaglandins E	26-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
16184416-4	2005	Recently, three different PGE synthases have been identified, that convert COX-2 metabolites into PGE2.	Dinoprostone	98-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
15961192-0	2005	Synthesis and SAR/3D-QSAR studies on the COX-2 inhibitory activity of 1,5-diarylpyrazoles to validate the modified pharmacophore.	1,5-diarylpyrazoles	70-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-46
15961192-1	2005	Diverse analogs of 1,5-diarylpyrazoles having 3-hydroxymethyl-4-sulfamoyl (SO2NH2)/methyl sulfonyl (SO2Me)-pheny group at N1 were synthesized and evaluated for their in vitro cyclooxygenase (COX-1/COX-2) inhibitory activity.	1,5-diarylpyrazoles	19-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	197-202
15961192-4	2005	3,4-dimethylphenyl analog 9, 3-methyl-4-methylsulfanylphenyl analog 14 and 2,3-dihydrobenzo[b]thiophenyl analog 17, exhibited impressive COX-2 inhibitory potency.	dimethylphenyl	4-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-142
15961192-4	2005	3,4-dimethylphenyl analog 9, 3-methyl-4-methylsulfanylphenyl analog 14 and 2,3-dihydrobenzo[b]thiophenyl analog 17, exhibited impressive COX-2 inhibitory potency.	2,3-dihydrobenzo[b]thiophenyl	75-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-142
16204585-7	2005	However, endogenous PGE2 levels were markedly decreased in LAM cells, and this was associated with decreased expression of the inducible form of cyclooxygenase (COX-2).	Dinoprostone	20-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	161-166
16197363-2	2005	Meloxicam is a non-steroidal anti-inflammatory drug (NSAID) of the oxicam class, and is a preferential inhibitor of COX-2, demonstrating effectiveness with anti-inflammatory, analgesic and antipyretic activity.	Meloxicam	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-121
16197363-2	2005	Meloxicam is a non-steroidal anti-inflammatory drug (NSAID) of the oxicam class, and is a preferential inhibitor of COX-2, demonstrating effectiveness with anti-inflammatory, analgesic and antipyretic activity.	oxicam	3-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-121
16178945-2	2005	BACKGROUND: Valdecoxib, an oral COX-2 specific inhibitor, is indicated for relief of the signs and symptoms of rheumatoid arthritis and osteoarthritis and treatment of primary dysmenorrhea.	valdecoxib	12-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-37
16178946-1	2005	OBJECTIVE: To evaluate the efficacy of single doses of lumiracoxib, the most selective cyclo-oxygenase (COX)-2 inhibitor, in the treatment of episodic tension-type headache (ETTH), with particular emphasis on time to onset of analgesia.	lumiracoxib	55-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-110
16178946-4	2005	Lumiracoxib is the most selective COX-2 inhibitor developed for the treatment of acute and chronic pain.	lumiracoxib	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-39
16091477-5	2005	DESIGN AND RESULTS: We investigated P-gp and COX-2 expression and then evaluated the sensitizing effects of COX-2 inhibitors on the cytotoxic effects of doxorubicin in the presence or in the absence of prostaglandin E2 in primary cultures and in a human MTC cell line, TT.	Doxorubicin	153-164	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-113
16091477-7	2005	Our data show that TT cells express both MDR1 and COX-2 and that rofecoxib, a selective COX-2 inhibitor, sensitizes TT cells to the cytotoxic effects of doxorubicin, reducing P-gp expression and function.	rofecoxib	65-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-93
16321305-1	2005	OBJECTIVE: To investigate the role of NS398, a selective cyclooxygenase (COX)-2 inhibitor, in proliferation and apoptosis of colorectal cancer, and to reveal the mechanism of inhibiting colon cancer by NS-398 Independent of COX-2.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	38-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-79
16253096-7	2005	Moreover, enhanced COX-2 mRNA repression was observed with triclosan and CPC in comparison to triclosan alone in IL-1beta and TNF-alpha stimulated cells.	Triclosan	59-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-24
16253096-7	2005	Moreover, enhanced COX-2 mRNA repression was observed with triclosan and CPC in comparison to triclosan alone in IL-1beta and TNF-alpha stimulated cells.	Triclosan	94-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-24
16253096-10	2005	CONCLUSION: This study indicates that triclosan and CPC are more effective at inhibiting PGE2 at the level of COX-2 gene regulation, and this combination may offer a potentially better anti-inflammatory agent in the treatment of inflammatory lesions in the oral cavity.	Triclosan	38-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-115
16253096-10	2005	CONCLUSION: This study indicates that triclosan and CPC are more effective at inhibiting PGE2 at the level of COX-2 gene regulation, and this combination may offer a potentially better anti-inflammatory agent in the treatment of inflammatory lesions in the oral cavity.	Cetylpyridinium	52-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-115
16253096-10	2005	CONCLUSION: This study indicates that triclosan and CPC are more effective at inhibiting PGE2 at the level of COX-2 gene regulation, and this combination may offer a potentially better anti-inflammatory agent in the treatment of inflammatory lesions in the oral cavity.	Dinoprostone	89-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-115
16205617-3	2005	Recently, it has been acquired that, among NSAIDs, nimesulide has a more selective action on the isoform COX-2 that is more strictly related to inflammatory phenomena.	nimesulide	51-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-110
16223182-7	2005	Glioma-infiltrating microglia are a major source of PGE2 production through the COX-2 pathway and support the use of COX-2 inhibitors as possible alternatives to glucocorticoids in the treatment of peritumoral edema in patients with malignant brain tumors.	Dinoprostone	52-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-85
16223182-7	2005	Glioma-infiltrating microglia are a major source of PGE2 production through the COX-2 pathway and support the use of COX-2 inhibitors as possible alternatives to glucocorticoids in the treatment of peritumoral edema in patients with malignant brain tumors.	Dinoprostone	52-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-122
16249351-0	2005	Combined therapy with weekly irinotecan, infusional 5-fluorouracil and the selective COX-2 inhibitor rofecoxib is a safe and effective second-line treatment in metastatic colorectal cancer.	rofecoxib	101-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-90
16171367-4	2005	The different response toward Zn(II), Ni(II), and Co(II) metal ions was also investigated and is reported.	Metals	57-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-56
16186874-2	2005	They reduce prostaglandins by inhibiting phospholipase A2 and the expression of COX-2 mRNA.	Prostaglandins	12-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-85
16321305-1	2005	OBJECTIVE: To investigate the role of NS398, a selective cyclooxygenase (COX)-2 inhibitor, in proliferation and apoptosis of colorectal cancer, and to reveal the mechanism of inhibiting colon cancer by NS-398 Independent of COX-2.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	38-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	224-229
16321305-8	2005	CONCLUSION: COX-2 inhibitor, such as NS-398 inhibits the colon cancer cell proliferation and induces apoptosis of colon cancer cells with the possible mechanism of inhibiting the proliferation and inducing the apoptosis of colon cancer cells through a pathway independent of COX-2.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	37-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-17
16321305-8	2005	CONCLUSION: COX-2 inhibitor, such as NS-398 inhibits the colon cancer cell proliferation and induces apoptosis of colon cancer cells with the possible mechanism of inhibiting the proliferation and inducing the apoptosis of colon cancer cells through a pathway independent of COX-2.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	37-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	275-280
15843495-7	2005	We observed that COX2 expression and PGE2 production induced by tumor necrosis factor alpha (TNF) were significantly abrogated by 15d-PGJ2.	15-deoxyprostaglandin J2	130-138	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-21
15825163-7	2005	We found that the selective COX-2 inhibitors NS398 and Nimesulide decreased mRNA expression and protein production of the integrin alpha5 subunit.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	45-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
15825163-7	2005	We found that the selective COX-2 inhibitors NS398 and Nimesulide decreased mRNA expression and protein production of the integrin alpha5 subunit.	nimesulide	55-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
15825163-13	2005	The Sp1 inhibitor, Mithramycin A, also blocked the inhibitory effect of the COX-2 inhibitors on alpha5 expression and promoter activity.	mithramycin A	19-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-81
16287549-1	2005	BACKGROUND: Nimesulide is a cyclooxygenase (COX) inhibitor with a high degree of selectivity to COX-2.	nimesulide	12-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-101
16363471-0	2005	Cu(II)-3-(5-chlor-2-hydroxy-3-sulfophenylazo)-6-(2,4,6-tribromophenylazo)-4,5-dihydroxynaphthalene-2,7-disulfonic Acid-Co(II) binuclear complexation and its application to the selective determination of cobalt at ng/ml level.	Cobalt	203-209	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-125
16363471-6	2005	The results showed that the technique is satisfactory to determine Co(II) at trace level in water samples with a detection limit of 2.3 ng/ml.	Water	92-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-73
16024204-8	2005	CONCLUSION: Proliferation of nasal polyps fibroblasts may be inhibited by Budesonide and a specific COX-2 inhibitor -Rofecoxib.	rofecoxib	117-126	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-105
16212229-1	2005	A number of 1,5-diarylimidazoles has been synthesized and evaluated for their inhibitory activities of COX-2 catalyzed PGE2 production.	1,5-diarylimidazoles	12-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-108
16212229-1	2005	A number of 1,5-diarylimidazoles has been synthesized and evaluated for their inhibitory activities of COX-2 catalyzed PGE2 production.	Dinoprostone	119-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-108
16212229-4	2005	Among the compounds tested, 1-(2,4-difluorophenyl)-5-(4-methylsulfonylphenyl)imidazole (2r) showed strong inhibitory activity, however, most diarylimidazoles exhibited little to low inhibitory activities against COX-2 catalyzed PGE2 production.	2r	88-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	212-217
16273333-1	2005	Cyclooxygenases (COX-1 and COX-2) catalyze the conversion of arachidonic acid to prostaglandins (PGs).	Prostaglandins	97-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-32
15993594-2	2005	The characterization of two cyclooxygenase isoforms (COX), the rate-limiting enzyme for the synthesis of prostaglandins (PGs) from arachidonic acid, has allowed the development of COX-2 selective inhibitors as non-steroidal anti-inflammatory drugs (NSAIDs) with significant gastric tolerability.	Prostaglandins	105-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	180-185
15993594-2	2005	The characterization of two cyclooxygenase isoforms (COX), the rate-limiting enzyme for the synthesis of prostaglandins (PGs) from arachidonic acid, has allowed the development of COX-2 selective inhibitors as non-steroidal anti-inflammatory drugs (NSAIDs) with significant gastric tolerability.	Prostaglandins	121-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	180-185
15993594-2	2005	The characterization of two cyclooxygenase isoforms (COX), the rate-limiting enzyme for the synthesis of prostaglandins (PGs) from arachidonic acid, has allowed the development of COX-2 selective inhibitors as non-steroidal anti-inflammatory drugs (NSAIDs) with significant gastric tolerability.	Arachidonic Acid	131-147	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	180-185
15993594-5	2005	The purpose of this study was to determine the inhibitory effects of some representative 4-thiazolidinones, already widely investigated as potential NSAIDs, on the growth of five human colon carcinoma cell lines with a different COX-2 expression, and to correlate them with COX-2 inhibitory properties.	4-thiazolidinone	89-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	229-234
15993594-5	2005	The purpose of this study was to determine the inhibitory effects of some representative 4-thiazolidinones, already widely investigated as potential NSAIDs, on the growth of five human colon carcinoma cell lines with a different COX-2 expression, and to correlate them with COX-2 inhibitory properties.	4-thiazolidinone	89-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	274-279
15878913-6	2005	The upregulation of cox-2 and cPLA2 was inhibited by flurbiprofen, a cyclooxygenase (COX) inhibitor, making this a second feed-forward enzyme in the eicosanoid pathway.	Flurbiprofen	53-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-25
15878913-6	2005	The upregulation of cox-2 and cPLA2 was inhibited by flurbiprofen, a cyclooxygenase (COX) inhibitor, making this a second feed-forward enzyme in the eicosanoid pathway.	Eicosanoids	149-159	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-25
16154102-3	2005	While this abnormal pattern of eicosanoid generation has been implicated in the development of vascular disease associated with COX-2 inhibition, its role in the development of hypertension, the most common cardiovascular complication associated with COX-2 inhibition, is not known.	Eicosanoids	31-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	128-133
15993933-1	2005	BACKGROUND: A pilot study was undertaken to determine the feasibility of examining a COX-2 inhibitor (Celecoxib) as a chemopreventive agent in women at increased risk of ovarian cancer undergoing risk reducing salpingoophorectomy.	Celecoxib	102-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-90
16273333-1	2005	Cyclooxygenases (COX-1 and COX-2) catalyze the conversion of arachidonic acid to prostaglandins (PGs).	Arachidonic Acid	61-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-32
16273333-1	2005	Cyclooxygenases (COX-1 and COX-2) catalyze the conversion of arachidonic acid to prostaglandins (PGs).	Prostaglandins	81-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-32
16273333-8	2005	Collectively, this assessment suggests potential involvement of PGs in the healing process of these tissues via modulation by non-selective NSAIDs and selective COX-2 inhibitors.	Prostaglandins	64-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	161-166
15963597-2	2005	COX-2 and its product, PGE2, play a role in hepatitis B and IL-18 has also been shown to inhibit HBV infection in vivo.	Dinoprostone	23-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
16385994-0	2005	Determination of trace amounts of cobalt using 1-(5-bromo-2-pyridylazo)-2-naphthol-6-sulfonic acid-Cu(II)-Co(II) competitive replacement complexation.	Cobalt	34-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-112
16385994-0	2005	Determination of trace amounts of cobalt using 1-(5-bromo-2-pyridylazo)-2-naphthol-6-sulfonic acid-Cu(II)-Co(II) competitive replacement complexation.	1-(5-bromo-2-pyridylazo)-2-naphthol-6-sulfonic acid	47-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-112
16385994-0	2005	Determination of trace amounts of cobalt using 1-(5-bromo-2-pyridylazo)-2-naphthol-6-sulfonic acid-Cu(II)-Co(II) competitive replacement complexation.	cu(ii)	99-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-112
16385994-1	2005	The chromophore 1-(5-bromo-2-pyridylazo)-2-naphthol-6-sulfonic acid (BPANS) has been used to sensitively complex Cu(II) and Co(II) in aqueous solution at pH 9.43.	1-(5-bromo-2-pyridylazo)-2-naphthol-6-sulfonic acid	16-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	124-130
16385994-1	2005	The chromophore 1-(5-bromo-2-pyridylazo)-2-naphthol-6-sulfonic acid (BPANS) has been used to sensitively complex Cu(II) and Co(II) in aqueous solution at pH 9.43.	1-(5-bromo-2-pyridylazo)-2-naphthol-6-sulfonic acid	69-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	124-130
15963597-5	2005	RESULTS: rHBsAg inhibits LPS-induced COX-2 expression in a time- and dose-dependent manner by blocking the ERK and NFkappaB pathways.	rhbsag	9-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-42
16247187-7	2005	It is concluded that endogenous PG originating mainly from upregulated COX-2 at the ulcer margin play crucial role in ulcer healing by exogenous PG, PPI, growth factors, gut hormones and melatonin, while COX-1 and COX-2 inhibitors delay ulcer healing by suppressing PG generation, and increasing COX-2 expression in the ulcer area.	Prostaglandins	32-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-76
15936165-0	2005	In situ generation of Co(II) by use of a solid-phase reactor in an FIA assembly for the spectrophotometric determination of penicillamine.	Penicillamine	124-137	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-27
15936165-2	2005	The manifold includes a solid-phase reactor for the in situ production of the derivatizing reagent, Co(II) ion, which forms a coloured complex with penicillamine in an alkaline medium.	Penicillamine	148-161	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-106
16247187-1	2005	Exogenous prostaglandins (PG) applied in small gastroprotective doses fail to affect healing of gastro-duodenal ulcers but accelerate the healing when used in larger gastric inhibitory doses that appear to enhance COX-2 expression and PGE(2) generation in the ulcer area.	Prostaglandins	10-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	214-219
16247187-1	2005	Exogenous prostaglandins (PG) applied in small gastroprotective doses fail to affect healing of gastro-duodenal ulcers but accelerate the healing when used in larger gastric inhibitory doses that appear to enhance COX-2 expression and PGE(2) generation in the ulcer area.	Prostaglandins	26-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	214-219
16247187-3	2005	Dexamethasone, that decreases the expression of COX-2 and mucosal generation of PGE(2), delays ulcer healing that can be reversed by the addition of small dose of exogenous PGE(2).	Dexamethasone	0-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-53
16247187-3	2005	Dexamethasone, that decreases the expression of COX-2 and mucosal generation of PGE(2), delays ulcer healing that can be reversed by the addition of small dose of exogenous PGE(2).	Prostaglandins E	173-176	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-53
16247187-4	2005	Proton pump inhibitors (PPI) such as omeprazole and PGE analogs, accelerate ulcer healing mainly due to potent inhibition of gastric acid secretion, but they also augment the COX-2 expression and enzyme activity in the ulcerated mucosa.	Omeprazole	37-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	175-180
16247187-4	2005	Proton pump inhibitors (PPI) such as omeprazole and PGE analogs, accelerate ulcer healing mainly due to potent inhibition of gastric acid secretion, but they also augment the COX-2 expression and enzyme activity in the ulcerated mucosa.	Prostaglandins E	52-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	175-180
16247187-5	2005	Endogenous PG generated at ulcer margin appear to be involved in ulcer healing promoted by growth factors and gut hormones such as gastrin or CCK and melatonin acting, at least in part, through increase of induction of COX-2 and local release of PGE(2) in the ulcer area.	Prostaglandins	11-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	219-224
16247187-5	2005	Endogenous PG generated at ulcer margin appear to be involved in ulcer healing promoted by growth factors and gut hormones such as gastrin or CCK and melatonin acting, at least in part, through increase of induction of COX-2 and local release of PGE(2) in the ulcer area.	Melatonin	150-159	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	219-224
16247187-6	2005	The ulcer healing activity of growth factors (e.g. EGF, TGF alpha, HGF) and certain gut hormones (gastrin, CCK) as well as melatonin, can be attenuated by treatment with COX-1 or COX-2 inhibitors which suppress the release of PGE(2) but enhance the expression of COX-2.	Prostaglandins E	226-229	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	179-184
16295777-1	2005	BACKGROUND: Cyclooxygenase (COX)-2 is the rate-limiting enzyme in prostaglandin synthesis.	Prostaglandins	66-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-34
15978791-2	2005	Originally, the beneficial effects of aspirin were shown to stem from its inhibition of cyclooxygenase (COX 2)-derived prostanoids, fatty acid metabolites that modulate host defense and regulate the cardiovascular system.	Aspirin	38-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
15978791-2	2005	Originally, the beneficial effects of aspirin were shown to stem from its inhibition of cyclooxygenase (COX 2)-derived prostanoids, fatty acid metabolites that modulate host defense and regulate the cardiovascular system.	Prostaglandins	119-130	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
15978791-2	2005	Originally, the beneficial effects of aspirin were shown to stem from its inhibition of cyclooxygenase (COX 2)-derived prostanoids, fatty acid metabolites that modulate host defense and regulate the cardiovascular system.	Fatty Acids	132-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
15978791-4	2005	Here, data from a series of comparatively recent experiments exploring aspirin"s unique ability to acetylate the active site of inducible COX 2 and generate a family of lipid mediators called the epi-Lipoxins will be discussed in light of their ability to exert profound modulatory effects on the innate and adaptive immune systems.	Aspirin	71-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	138-143
16113940-3	2005	NSAIDs block the activity of both COX isozymes, COX-1 and COX-2, which mediate the enzymatic conversion of arachidonate to prostaglandin H2 (PGH2) and other prostaglandin (PG) metabolites.	Arachidonic Acid	107-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
16113940-3	2005	NSAIDs block the activity of both COX isozymes, COX-1 and COX-2, which mediate the enzymatic conversion of arachidonate to prostaglandin H2 (PGH2) and other prostaglandin (PG) metabolites.	Prostaglandin H2	123-139	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
16113940-3	2005	NSAIDs block the activity of both COX isozymes, COX-1 and COX-2, which mediate the enzymatic conversion of arachidonate to prostaglandin H2 (PGH2) and other prostaglandin (PG) metabolites.	Prostaglandin H2	141-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
16113940-3	2005	NSAIDs block the activity of both COX isozymes, COX-1 and COX-2, which mediate the enzymatic conversion of arachidonate to prostaglandin H2 (PGH2) and other prostaglandin (PG) metabolites.	Prostaglandins	123-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
16113940-3	2005	NSAIDs block the activity of both COX isozymes, COX-1 and COX-2, which mediate the enzymatic conversion of arachidonate to prostaglandin H2 (PGH2) and other prostaglandin (PG) metabolites.	Prostaglandins	141-143	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
16113940-4	2005	It is well established that the cardiovascular profile of COX-2 inhibitors can be accounted for by inhibition of COX-dependent PG synthesis.	Prostaglandins	127-129	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
16113940-7	2005	Although COX-1 and COX-2 exhibit similar biochemical activity in converting arachidonate to PGH2 in vitro, the ultimate prostanoids they produce in vivo may be different due to differential regulation of COX-1 and COX-2, tissue distribution, and availability of the prostanoid synthases.	Arachidonic Acid	76-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-24
16113940-7	2005	Although COX-1 and COX-2 exhibit similar biochemical activity in converting arachidonate to PGH2 in vitro, the ultimate prostanoids they produce in vivo may be different due to differential regulation of COX-1 and COX-2, tissue distribution, and availability of the prostanoid synthases.	Prostaglandin H2	92-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-24
16113940-7	2005	Although COX-1 and COX-2 exhibit similar biochemical activity in converting arachidonate to PGH2 in vitro, the ultimate prostanoids they produce in vivo may be different due to differential regulation of COX-1 and COX-2, tissue distribution, and availability of the prostanoid synthases.	Prostaglandins	120-131	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	214-219
15915519-6	2005	Preparative scale electrolyses carried out from solutions containing aromatic halides (ArX), vinyl acetate (vinylOAc) and a catalytic amount of CoBr(2)bpy lead to a mixture of biaryl (Ar-Ar) and arene (ArH) as long as the potential is set on the plateau of the Co(II) right arrow over left arrow Co(I) reduction wave.	cobr(2)bpy	144-154	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	261-267
15915519-6	2005	Preparative scale electrolyses carried out from solutions containing aromatic halides (ArX), vinyl acetate (vinylOAc) and a catalytic amount of CoBr(2)bpy lead to a mixture of biaryl (Ar-Ar) and arene (ArH) as long as the potential is set on the plateau of the Co(II) right arrow over left arrow Co(I) reduction wave.	Biaryl	176-182	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	261-267
15915519-6	2005	Preparative scale electrolyses carried out from solutions containing aromatic halides (ArX), vinyl acetate (vinylOAc) and a catalytic amount of CoBr(2)bpy lead to a mixture of biaryl (Ar-Ar) and arene (ArH) as long as the potential is set on the plateau of the Co(II) right arrow over left arrow Co(I) reduction wave.	MLS000560220	184-189	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	261-267
16038624-4	2005	The first selective COX-2 inhibitor, celecoxib, entered the market in December 1998 [corrected] However, there are a few organs that physiologically and functionally express COX-2, particularly the glomeruli of the kidney and the cortex of the brain.	Celecoxib	37-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-25
16038624-4	2005	The first selective COX-2 inhibitor, celecoxib, entered the market in December 1998 [corrected] However, there are a few organs that physiologically and functionally express COX-2, particularly the glomeruli of the kidney and the cortex of the brain.	Celecoxib	37-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	174-179
15840770-0	2005	COX-2 inhibition prevents downregulation of key renal water and sodium transport proteins in response to bilateral ureteral obstruction.	Water	54-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
16158132-0	2005	Diversity in magnetic properties of 3D isomorphous networks of Co(II) and Mn(II) constructed by napthalene-1,4-dicarboxylate.	napthalene-1,4-dicarboxylate	96-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-69
16102103-5	2005	Recent studies from our group suggest that variable expression of upstream and downstream enzymes in the prostanoid biosynthetic cascade may represent important determinants of the functional consequences of COX-2 expression and inhibition in different clinical settings.	Prostaglandins	105-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	208-213
16170019-10	2005	COX-2 expression was reduced by tricin weakly in HCEC and unaffected in HCA-7 cells.	tricin	32-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
16024242-3	2005	Indeed, suppression of aspirin-triggered lipoxin synthesis, through co-administration of a selective COX-2 inhibitor, results in a significant exacerbation of gastric injury.	Aspirin	23-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-106
16024242-3	2005	Indeed, suppression of aspirin-triggered lipoxin synthesis, through co-administration of a selective COX-2 inhibitor, results in a significant exacerbation of gastric injury.	Lipoxins	41-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-106
16194481-2	2005	Prevention of breast cancer with tamoxifen, of squamous cell skin cancer with actinic keratosis by diclofenac gel and in familial polyposis with anti-inflammatory drug (COX-2) celecoxib is considered of health care clinical use.	Celecoxib	176-185	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	169-174
16005433-0	2005	Curcumin inhibits interferon-alpha induced NF-kappaB and COX-2 in human A549 non-small cell lung cancer cells.	Curcumin	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-62
16005433-4	2005	Curcumin also inhibited IFN-alpha-induced COX-2 expression in A549 cells.	Curcumin	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47
16005433-6	2005	Taken together, IFN-alpha-induced activations of NF-kappaB and COX-2 were inhibited by the addition of curcumin in A549 cells.	Curcumin	103-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-68
16097814-0	2005	Novel self-assembled chain of water molecules in a metal-organic framework structure of Co(II) with tartrate acid.	Water	30-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-93
16097814-0	2005	Novel self-assembled chain of water molecules in a metal-organic framework structure of Co(II) with tartrate acid.	Metals	51-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-93
16097814-0	2005	Novel self-assembled chain of water molecules in a metal-organic framework structure of Co(II) with tartrate acid.	tartrate acid	100-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-93
16097815-0	2005	Isolated magnetic clusters of Co(II) and Ni(II) within 3-dimensional organic frameworks of 6-mercaptonicotinic acid: unique structural topologies based on selectivity for hard and soft coordination environments.	6-Mercaptonicotinic acid	91-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-36
16091148-8	2005	In addition, isoproterenol activation of these same cells led to significant increases in the amount of phosphorylated extracellular signal-regulated kinase (pERK), inducible nitric oxide synthase (iNOS) and the induced form of cyclooxygenase (COX-2) when compared to control.	Isoproterenol	13-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	244-249
16091148-11	2005	However, the increased production of iNOS and COX-2 by isoproterenol is not blocked when UROtsa cells are preincubated with inhibitors of PKA.	Isoproterenol	55-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
15840770-12	2005	These data indicate that COX-2 may be an important factor contributing to the impaired renal water and sodium handling in response to BUO.	Sodium	103-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-30
15840770-12	2005	These data indicate that COX-2 may be an important factor contributing to the impaired renal water and sodium handling in response to BUO.	Diacetyl	134-137	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-30
16021422-2	2005	These exploit the enhancement of the cobalt peak obtained by using the Co(II)-dimethylglyoxime-cetyltrimethylammonium bromide-piperazine-N,N"-bis(2-ethanesulfonic acid) system.	Cobalt	37-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-76
16122163-1	2005	This work proposes a new method for Co(II) determination based on the use of the triblock copolymer as micellar medium instead of chloroform.	triblock copolymer	81-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-41
16122163-1	2005	This work proposes a new method for Co(II) determination based on the use of the triblock copolymer as micellar medium instead of chloroform.	Chloroform	130-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-41
16042570-6	2005	As PGE2 is thought to be the major PG species responsible for promoting colorectal tumorigenesis, research is being directed to a number of protein targets downstream of COX-2 that might allow the selective inhibition of the tumour-promoting activities of PGE2, while minimizing the associated adverse events.	Dinoprostone	256-260	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	170-175
16042585-3	2005	The increased prostaglandin E2 levels and the overexpression of COX-2 in colon and many other cancers provided the rationale for clinical trials with COX-2 inhibitors for cancer prevention or treatment.	Dinoprostone	14-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	150-155
16178410-3	2005	Most wogonin derivatives exhibited much reduced inhibitory activities against COX-2 catalyzed PGE2 production compared to that of wogonin.	Dinoprostone	94-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-83
15814897-8	2005	The Cox2 mRNA increase paralleled the cAMP raise, suggesting that LH uses the cAMP second messenger system.	Cyclic AMP	78-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-8
15990304-4	2005	Additionally, FlexX and CoMFA results also suggested that etoricoxib, another selective COX-2 inhibitor, could inhibit p38 MAP kinase.	Etoricoxib	58-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-93
16710939-0	2005	PGE2 produced by lung cancer suppresses immune function through T-regulatory cells and can be blocked by the COX2 inhibitor Celebrex.	Dinoprostone	0-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-113
16710939-0	2005	PGE2 produced by lung cancer suppresses immune function through T-regulatory cells and can be blocked by the COX2 inhibitor Celebrex.	Celecoxib	124-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-113
16083531-4	2005	Non-selective NSAIDs such as ibuprofen and naproxen, which inhibit both COX-1 and COX-2, have proven highly effective and safe in the short-term management of acute pain.	Ibuprofen	29-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
16083531-4	2005	Non-selective NSAIDs such as ibuprofen and naproxen, which inhibit both COX-1 and COX-2, have proven highly effective and safe in the short-term management of acute pain.	Naproxen	43-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
16083531-5	2005	Highly selective COX-2 inhibitors including celecoxib, rofecoxib, valdecoxib, lumiracoxib, and etoricoxib were developed with the hope of significantly reducing the serious gastrointestinal toxicities associated with chronic high-dose NSAID use.	Celecoxib	44-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22
16083531-5	2005	Highly selective COX-2 inhibitors including celecoxib, rofecoxib, valdecoxib, lumiracoxib, and etoricoxib were developed with the hope of significantly reducing the serious gastrointestinal toxicities associated with chronic high-dose NSAID use.	rofecoxib	55-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22
16083531-5	2005	Highly selective COX-2 inhibitors including celecoxib, rofecoxib, valdecoxib, lumiracoxib, and etoricoxib were developed with the hope of significantly reducing the serious gastrointestinal toxicities associated with chronic high-dose NSAID use.	valdecoxib	66-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22
16083531-5	2005	Highly selective COX-2 inhibitors including celecoxib, rofecoxib, valdecoxib, lumiracoxib, and etoricoxib were developed with the hope of significantly reducing the serious gastrointestinal toxicities associated with chronic high-dose NSAID use.	lumiracoxib	78-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22
16083531-5	2005	Highly selective COX-2 inhibitors including celecoxib, rofecoxib, valdecoxib, lumiracoxib, and etoricoxib were developed with the hope of significantly reducing the serious gastrointestinal toxicities associated with chronic high-dose NSAID use.	Etoricoxib	95-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22
15997464-2	2005	Up-regulation of COX-2 expression is responsible for increased PG release during inflammatory conditions and is thought to be also involved in allergic states.	Prostaglandins	63-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22
16922642-1	2005	Etoricoxib is a highly selective COX-2 inhibitor (coxib) approved in Europe for the treatment of osteoarthritis (OA), rheumatoid arthritis and acute gouty arthritis.	Etoricoxib	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-38
16922642-7	2005	Similarly to other selective COX-2 inhibitors, etoricoxib is contraindicated in patients with ischaemic heart disease or stroke and it should be used with caution in patients with risk factors for heart disease.	Etoricoxib	47-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34
16010430-7	2005	Furthermore, TSA decreased the levels of COX-2 mRNA and protein expression without significant changes in the levels of COX-1, which was correlated with an inhibition in prostaglandin E2 synthesis.	trichostatin A	13-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-46
15668944-8	2005	Also, inhibitors of the cyclo-oxygenase (Cox) enzymes, such as N-[2-cyclohexyloxy)-4-nitrophenyl]-methanesulfonamide (NS-398), a specific Cox-2 inhibitor, or indomethacin, a non-specific Cox inhibitor, blocked NO-induced PGE(2) production and apoptosis of vascular smooth muscle cells to the same extent, indicating that apoptosis might be induced by a Cox-2 metabolic product.	methanesulfonamide	98-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	138-143
15668944-8	2005	Also, inhibitors of the cyclo-oxygenase (Cox) enzymes, such as N-[2-cyclohexyloxy)-4-nitrophenyl]-methanesulfonamide (NS-398), a specific Cox-2 inhibitor, or indomethacin, a non-specific Cox inhibitor, blocked NO-induced PGE(2) production and apoptosis of vascular smooth muscle cells to the same extent, indicating that apoptosis might be induced by a Cox-2 metabolic product.	methanesulfonamide	98-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	353-358
15668944-8	2005	Also, inhibitors of the cyclo-oxygenase (Cox) enzymes, such as N-[2-cyclohexyloxy)-4-nitrophenyl]-methanesulfonamide (NS-398), a specific Cox-2 inhibitor, or indomethacin, a non-specific Cox inhibitor, blocked NO-induced PGE(2) production and apoptosis of vascular smooth muscle cells to the same extent, indicating that apoptosis might be induced by a Cox-2 metabolic product.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	118-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	138-143
15668944-8	2005	Also, inhibitors of the cyclo-oxygenase (Cox) enzymes, such as N-[2-cyclohexyloxy)-4-nitrophenyl]-methanesulfonamide (NS-398), a specific Cox-2 inhibitor, or indomethacin, a non-specific Cox inhibitor, blocked NO-induced PGE(2) production and apoptosis of vascular smooth muscle cells to the same extent, indicating that apoptosis might be induced by a Cox-2 metabolic product.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	118-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	353-358
15975667-5	2005	Since the action of the indole on COX-2 has not been previously described, the goal of the present report was to test the effect of melatonin on the activities of COX-2 and inducible nitric oxide synthase (iNOS), using lipopolysaccharide (LPS)-activated RAW 264.7 macrophages as a model.	indole	24-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-39
15975667-5	2005	Since the action of the indole on COX-2 has not been previously described, the goal of the present report was to test the effect of melatonin on the activities of COX-2 and inducible nitric oxide synthase (iNOS), using lipopolysaccharide (LPS)-activated RAW 264.7 macrophages as a model.	Melatonin	132-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	163-168
15975667-6	2005	Melatonin and its metabolites, N1-acetyl-N2-formyl-5-methoxykynuramine (AFMK) and N1-acetyl-5-methoxykynuramine (AMK), prevented COX-2 activation induced by LPS, without affecting COX-1 protein levels.	Melatonin	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-134
15975667-6	2005	Melatonin and its metabolites, N1-acetyl-N2-formyl-5-methoxykynuramine (AFMK) and N1-acetyl-5-methoxykynuramine (AMK), prevented COX-2 activation induced by LPS, without affecting COX-1 protein levels.	AFMK	31-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-134
15975667-6	2005	Melatonin and its metabolites, N1-acetyl-N2-formyl-5-methoxykynuramine (AFMK) and N1-acetyl-5-methoxykynuramine (AMK), prevented COX-2 activation induced by LPS, without affecting COX-1 protein levels.	N-acetyl-5-methoxy kynurenamine	82-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-134
15975667-7	2005	The structurally related compound 6-methoxy-melatonin only partially prevented the increase in COX-2 protein levels induced by the toxin.	6-methoxy-melatonin	34-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-100
15975667-10	2005	The current finding corroborates a role of melatonin as an anti-inflammatory agent and, for the first time, COX-2 and iNOS as molecular targets for either melatonin or its metabolites AFMK and AMK.	Melatonin	155-164	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-113
15870389-1	2005	We have already demonstrated that celecoxib, a selective cyclooxygenase (COX)-2 inhibitor, has a proapoptotic effect on synovial fibroblasts obtained from patients with rheumatoid arthritis (RA).	Celecoxib	34-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-79
15870389-10	2005	The order of potency of the COX-2 inhibitory activity of these drugs in RA synovial fibroblasts was celecoxib = SC-236 &gt; rofecoxib &gt; TT201 &gt; TT101.	Celecoxib	100-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
15870389-10	2005	The order of potency of the COX-2 inhibitory activity of these drugs in RA synovial fibroblasts was celecoxib = SC-236 &gt; rofecoxib &gt; TT201 &gt; TT101.	4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide	112-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
15870389-10	2005	The order of potency of the COX-2 inhibitory activity of these drugs in RA synovial fibroblasts was celecoxib = SC-236 &gt; rofecoxib &gt; TT201 &gt; TT101.	rofecoxib	124-133	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
16006977-0	2005	Aspirin, ibuprofen, and other non-steroidal anti-inflammatory drugs in cancer prevention: a critical review of non-selective COX-2 blockade (review).	Aspirin	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-130
16012733-8	2005	Furthermore, Chan Su decreased the levels of COX-2 mRNA and protein expression without significant changes in the levels of COX-1, which was correlated with an inhibition in prostaglandin E(2) synthesis.	chan su	13-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-50
15982930-0	2005	Thalidomide inhibits growth of tumors through COX-2 degradation independent of antiangiogenesis.	Thalidomide	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
15982930-7	2005	Thalidomide reduced COX-2 expression accompanied by a decrease of bcl-2 protein, TNFalpha, VEGF, GSH and an increased cytochrome c, but had no effect on that of COX-1, in MCF-7 and HL-60.	Thalidomide	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-25
15982930-7	2005	Thalidomide reduced COX-2 expression accompanied by a decrease of bcl-2 protein, TNFalpha, VEGF, GSH and an increased cytochrome c, but had no effect on that of COX-1, in MCF-7 and HL-60.	Glutathione	97-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-25
15982930-10	2005	Effect of thalidomide on COX-1 and COX-2 in vivo was consistent with that of in vitro.	Thalidomide	10-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40
15982930-11	2005	These results demonstrated that thalidomide might inhibit growth of tumors through COX-2 degradation independent of antiangiogenesis.	Thalidomide	32-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
15950941-3	2005	Flow cytometry analysis suggests that IL-20-dependent inhibition of COX-2/PGE(2) occurs through the IL-22R1/IL-20R2 dimers.	Prostaglandins E	74-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-73
15950941-5	2005	IL-20-mediated inhibition of PMA-induced angiogenesis occurs through the COX-2 regulatory pathway.	Tetradecanoylphorbol Acetate	29-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-78
15950941-6	2005	Altogether our findings revealed that IL-20 is a negative modulator of COX-2/PGE(2) and inhibits angiogenesis.	Prostaglandins E	77-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-76
16852752-4	2005	The investigation of the xerogels and aerogels calcined at increasing temperature indicates that Fe(III) and Co(II) ions are present and they are located in the tetrahedral sites of the spinel structure of the matrix (gamma-Al2O3); moreover, the precursor of the spinel is more ordered in the aerogel sample than the xerogel sample.	gamma-al2o3)	218-230	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-115
15917246-1	2005	Cyclooxygenase (COX)-2 oxygenates arachidonic acid (AA) and 2-arachidonylglycerol (2-AG) to endoperoxides, which are subsequently transformed to prostaglandins (PGs) and glycerylprostaglandins (PG-Gs).	Arachidonic Acid	34-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-22
15917246-1	2005	Cyclooxygenase (COX)-2 oxygenates arachidonic acid (AA) and 2-arachidonylglycerol (2-AG) to endoperoxides, which are subsequently transformed to prostaglandins (PGs) and glycerylprostaglandins (PG-Gs).	glyceryl 2-arachidonate	60-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-22
15917246-1	2005	Cyclooxygenase (COX)-2 oxygenates arachidonic acid (AA) and 2-arachidonylglycerol (2-AG) to endoperoxides, which are subsequently transformed to prostaglandins (PGs) and glycerylprostaglandins (PG-Gs).	glyceryl 2-arachidonate	83-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-22
15917246-1	2005	Cyclooxygenase (COX)-2 oxygenates arachidonic acid (AA) and 2-arachidonylglycerol (2-AG) to endoperoxides, which are subsequently transformed to prostaglandins (PGs) and glycerylprostaglandins (PG-Gs).	endoperoxides	92-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-22
15917246-1	2005	Cyclooxygenase (COX)-2 oxygenates arachidonic acid (AA) and 2-arachidonylglycerol (2-AG) to endoperoxides, which are subsequently transformed to prostaglandins (PGs) and glycerylprostaglandins (PG-Gs).	Prostaglandins	145-159	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-22
15917246-1	2005	Cyclooxygenase (COX)-2 oxygenates arachidonic acid (AA) and 2-arachidonylglycerol (2-AG) to endoperoxides, which are subsequently transformed to prostaglandins (PGs) and glycerylprostaglandins (PG-Gs).	Prostaglandins	161-164	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-22
15917246-1	2005	Cyclooxygenase (COX)-2 oxygenates arachidonic acid (AA) and 2-arachidonylglycerol (2-AG) to endoperoxides, which are subsequently transformed to prostaglandins (PGs) and glycerylprostaglandins (PG-Gs).	glycerylprostaglandins	170-192	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-22
15917246-1	2005	Cyclooxygenase (COX)-2 oxygenates arachidonic acid (AA) and 2-arachidonylglycerol (2-AG) to endoperoxides, which are subsequently transformed to prostaglandins (PGs) and glycerylprostaglandins (PG-Gs).	Prostaglandins G	194-199	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-22
15917246-7	2005	The selective COX-2 inhibitor, SC236, reduced PG-G and PG production by 49 and 17%, respectively, indicating a significant role for COX-1 in PG-G and especially PG synthesis.	4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide	31-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
15917246-7	2005	The selective COX-2 inhibitor, SC236, reduced PG-G and PG production by 49 and 17%, respectively, indicating a significant role for COX-1 in PG-G and especially PG synthesis.	Prostaglandins G	46-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
15917246-7	2005	The selective COX-2 inhibitor, SC236, reduced PG-G and PG production by 49 and 17%, respectively, indicating a significant role for COX-1 in PG-G and especially PG synthesis.	Prostaglandins	46-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
15917246-7	2005	The selective COX-2 inhibitor, SC236, reduced PG-G and PG production by 49 and 17%, respectively, indicating a significant role for COX-1 in PG-G and especially PG synthesis.	Prostaglandins G	141-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
15917246-7	2005	The selective COX-2 inhibitor, SC236, reduced PG-G and PG production by 49 and 17%, respectively, indicating a significant role for COX-1 in PG-G and especially PG synthesis.	Prostaglandins	55-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
15917246-8	2005	Time course studies indicated that COX-2-dependent oxygenation rapidly declined 20 min after zymosan addition.	Zymosan	93-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40
15917246-10	2005	SC236 reduced PG-G and PG production from exogenous 2-AG by 88 and 76%, respectively, indicating a more significant role for COX-2 in the utilization of exogenous substrate.	4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide	0-5	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-130
15921858-7	2005	In this context, the recently delineated interplay between COX-2-derived PG signaling and other growth-regulatory pathways, such as EGFR, ErbB2, IL-6/GP130, HGF/Met, TGF-beta/Smad, and iNOS is expected to provide important therapeutic implications.	Prostaglandins	73-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-64
15921858-8	2005	This review will summarize the recent advances in understanding the mechanisms for COX-2-derived PG signaling in cholangiocarcinogenesis and focus on the newly unveiled interactions between PG cascade and other key signaling pathways that coordinately regulate cholangiocarcinoma growth.	Prostaglandins	97-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
15964308-15	2005	Blocking COX-2 by NS-398 blunted the antiproliferative effect of ZR.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	18-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	9-14
15964308-15	2005	Blocking COX-2 by NS-398 blunted the antiproliferative effect of ZR.	Zirconium	65-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	9-14
15998028-6	2005	The irreversibility displayed by all of the complexes is probably related to an electron-transfer process followed by a rearrangement of the geometry around the metal center for complexes 1 and 3-5 that probably changes from a trigonal bipyramidal (high spin, d7) to octahedral (low spin, d6) as Co(II) is oxidized to Co(III), which is also expected to be accompanied by a spin-state conversion.	Metals	161-166	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	296-302
15998028-7	2005	As the redox potentials to convert the Co(II) to Co(III) are high, it can be inferred that the redox potential of the Co(II)-substituted SOD may be outside the range required to convert the superoxide radical (O2*-) to hydrogen peroxide, and this is sufficient to explain the inactivity of the enzyme.	Superoxides	190-208	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-45
15998028-7	2005	As the redox potentials to convert the Co(II) to Co(III) are high, it can be inferred that the redox potential of the Co(II)-substituted SOD may be outside the range required to convert the superoxide radical (O2*-) to hydrogen peroxide, and this is sufficient to explain the inactivity of the enzyme.	Superoxides	190-208	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-124
15998028-7	2005	As the redox potentials to convert the Co(II) to Co(III) are high, it can be inferred that the redox potential of the Co(II)-substituted SOD may be outside the range required to convert the superoxide radical (O2*-) to hydrogen peroxide, and this is sufficient to explain the inactivity of the enzyme.	Superoxides	210-215	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-45
15998028-7	2005	As the redox potentials to convert the Co(II) to Co(III) are high, it can be inferred that the redox potential of the Co(II)-substituted SOD may be outside the range required to convert the superoxide radical (O2*-) to hydrogen peroxide, and this is sufficient to explain the inactivity of the enzyme.	Superoxides	210-215	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-124
15998028-7	2005	As the redox potentials to convert the Co(II) to Co(III) are high, it can be inferred that the redox potential of the Co(II)-substituted SOD may be outside the range required to convert the superoxide radical (O2*-) to hydrogen peroxide, and this is sufficient to explain the inactivity of the enzyme.	Hydrogen Peroxide	219-236	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-45
15998028-7	2005	As the redox potentials to convert the Co(II) to Co(III) are high, it can be inferred that the redox potential of the Co(II)-substituted SOD may be outside the range required to convert the superoxide radical (O2*-) to hydrogen peroxide, and this is sufficient to explain the inactivity of the enzyme.	Hydrogen Peroxide	219-236	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-124
15997066-3	2005	Each Co(II) ion is five-coordinated by two O and two N atoms from a Schiff base ligand, and by another bridging phenolate O atom from another Schiff base ligand, giving a severely distorted trigonal-bipyramidal coordination environment.	Nitrogen	53-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	5-11
15997066-3	2005	Each Co(II) ion is five-coordinated by two O and two N atoms from a Schiff base ligand, and by another bridging phenolate O atom from another Schiff base ligand, giving a severely distorted trigonal-bipyramidal coordination environment.	Schiff Bases	68-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	5-11
15997066-3	2005	Each Co(II) ion is five-coordinated by two O and two N atoms from a Schiff base ligand, and by another bridging phenolate O atom from another Schiff base ligand, giving a severely distorted trigonal-bipyramidal coordination environment.	Schiff Bases	142-153	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	5-11
16111170-12	2005	Because selective COX-2 inhibitors have an improved therapeutic index relative to nonselective nonsteroidal anti-inflammatory drugs in humans, firocoxib has the potential to be a safe, effective anti-inflammatory agent for cats.	firocoxib	143-152	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-23
16247187-7	2005	It is concluded that endogenous PG originating mainly from upregulated COX-2 at the ulcer margin play crucial role in ulcer healing by exogenous PG, PPI, growth factors, gut hormones and melatonin, while COX-1 and COX-2 inhibitors delay ulcer healing by suppressing PG generation, and increasing COX-2 expression in the ulcer area.	Prostaglandins	32-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	214-219
16247187-7	2005	It is concluded that endogenous PG originating mainly from upregulated COX-2 at the ulcer margin play crucial role in ulcer healing by exogenous PG, PPI, growth factors, gut hormones and melatonin, while COX-1 and COX-2 inhibitors delay ulcer healing by suppressing PG generation, and increasing COX-2 expression in the ulcer area.	Prostaglandins	32-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	214-219
16247187-7	2005	It is concluded that endogenous PG originating mainly from upregulated COX-2 at the ulcer margin play crucial role in ulcer healing by exogenous PG, PPI, growth factors, gut hormones and melatonin, while COX-1 and COX-2 inhibitors delay ulcer healing by suppressing PG generation, and increasing COX-2 expression in the ulcer area.	Prostaglandins	145-147	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-76
16247187-7	2005	It is concluded that endogenous PG originating mainly from upregulated COX-2 at the ulcer margin play crucial role in ulcer healing by exogenous PG, PPI, growth factors, gut hormones and melatonin, while COX-1 and COX-2 inhibitors delay ulcer healing by suppressing PG generation, and increasing COX-2 expression in the ulcer area.	Melatonin	187-196	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-76
15852032-2	2005	AZD3582 [4-(nitrooxy)butyl-(2S)-2-(6-methoxy-2-naphthyl)propanoate] is a COX-inhibiting nitric oxide donor that inhibits COX-1 and COX-2.	naproxen-n-butyl nitrate	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-136
16247187-7	2005	It is concluded that endogenous PG originating mainly from upregulated COX-2 at the ulcer margin play crucial role in ulcer healing by exogenous PG, PPI, growth factors, gut hormones and melatonin, while COX-1 and COX-2 inhibitors delay ulcer healing by suppressing PG generation, and increasing COX-2 expression in the ulcer area.	Prostaglandins	145-147	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-76
15852032-2	2005	AZD3582 [4-(nitrooxy)butyl-(2S)-2-(6-methoxy-2-naphthyl)propanoate] is a COX-inhibiting nitric oxide donor that inhibits COX-1 and COX-2.	naproxen-n-butyl nitrate	9-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-136
15998959-6	2005	RESULTS: Patients with a history of gastropathy were more likely to be prescribed COX-2 inhibitors than low-dose NSAIDs; the odds ratios were 1.73 (95%CI: 1.56-1.91) and 1.49 (1.33-1.66), respectively for celecoxib and rofecoxib.	Celecoxib	205-214	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
15852032-2	2005	AZD3582 [4-(nitrooxy)butyl-(2S)-2-(6-methoxy-2-naphthyl)propanoate] is a COX-inhibiting nitric oxide donor that inhibits COX-1 and COX-2.	Nitric Oxide	88-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-136
15998959-6	2005	RESULTS: Patients with a history of gastropathy were more likely to be prescribed COX-2 inhibitors than low-dose NSAIDs; the odds ratios were 1.73 (95%CI: 1.56-1.91) and 1.49 (1.33-1.66), respectively for celecoxib and rofecoxib.	rofecoxib	219-228	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
16053517-2	2005	We therefore investigated the effect of a COX-2 inhibitor, JTE-522, on the ability of orthotopic fibroblasts to stimulate invasion of scirrhous gastric carcinoma cells.	4-(4-cyclohexyl-2-methyloxazol-5-yl)-2-fluorobenzenesulfonamide	59-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47
16098242-5	2005	Ample preclinical data suggest that the COX-2/prostaglandin E2 (PGE2) signaling pathway plays a pivotal role in conferring the malignant phenotype.	Dinoprostone	46-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
16053517-10	2005	In conclusion, we found that gastric fibroblasts stimulated invasiveness in scirrhous gastric cancer cells, whereas a selective COX-2 inhibitor inhibited this paracrine effect by decreasing fibroblast PGE2 production, resulting in downregulation of HGF production.	Dinoprostone	201-205	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	128-133
17193179-0	2005	The furoxan system: design of selective nitric oxide (NO) donor inhibitors of COX-2 endowed with anti-aggregatory and vasodilating activities.	1,2,5-oxadiazole 2-oxide	4-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-83
17193179-0	2005	The furoxan system: design of selective nitric oxide (NO) donor inhibitors of COX-2 endowed with anti-aggregatory and vasodilating activities.	Nitric Oxide	40-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-83
17193179-2	2005	The products were found to be selective COX-2 inhibitors, similar to the structurally related furazans (3,4-diphenyl-1,2,5-oxadiazole), devoid of the NO release property.	3,4-Diphenyl-1,2,5-oxadiazole	104-133	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
17193179-5	2005	These properties can be modulated by inserting an appropriate spacer between the 4-phenyl group and the furoxan ring, giving rise to new, selective COX-2 furoxan derivatives endowed with anti-aggregatory and vasodilating activities, and with potentially reduced cardiotoxicities.	1,2,5-oxadiazole 2-oxide	104-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	148-153
17193179-5	2005	These properties can be modulated by inserting an appropriate spacer between the 4-phenyl group and the furoxan ring, giving rise to new, selective COX-2 furoxan derivatives endowed with anti-aggregatory and vasodilating activities, and with potentially reduced cardiotoxicities.	1,2,5-oxadiazole 2-oxide	154-161	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	148-153
16098242-5	2005	Ample preclinical data suggest that the COX-2/prostaglandin E2 (PGE2) signaling pathway plays a pivotal role in conferring the malignant phenotype.	Dinoprostone	64-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
15967068-3	2005	Skin reactions triggered by aspirin are associated with the inhibition of cyclooxygenase, specifically COX-1, but not COX-2, and are characterized by overproduction of cysteinyl leukotrienes (cys-LTs).	Aspirin	28-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-123
16098242-6	2005	Produced primarily by the action of COX on the free arachidonic acid liberated from membrane phospholipids, overproduction of PGE2, which is predominantly generated by upregulation of COX-2, is associated with a variety of mechanisms known to facilitate tumorigenesis.	Dinoprostone	126-130	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	184-189
15931525-7	2005	FC-77 also attenuated the LPS-induced PGE2 formation accompanied by suppressing COX-2 expression, the degradation of cytosolic inhibitor of kappaB-alpha and NF-kappaB activation.	fluorocarbon 77	0-5	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-85
16190133-4	2005	The inhibitory action of aspirin on COX-1 and COX-2 enzymes enhances the tissue concentrations of dihomo-gamma-linolenic acid (DGLA), arachidonic acid, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).	Docosahexaenoic Acids	185-205	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
15990799-0	2005	Association of COX-2 gene haplotypes with prostaglandins production in bronchial asthma.	Prostaglandins	42-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-20
16190133-0	2005	Can COX-2 inhibitor-induced increase in cardiovascular disease risk be modified by essential fatty acids?	Fatty Acids, Essential	83-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
16190133-4	2005	The inhibitory action of aspirin on COX-1 and COX-2 enzymes enhances the tissue concentrations of dihomo-gamma-linolenic acid (DGLA), arachidonic acid, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).	Docosahexaenoic Acids	207-210	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
16190133-2	2005	This has been attributed to their ability to inhibit endothelial COX-2 derived prostacyclin (PGI2) but not platelet COX-1 derived thromboxane A2 (TXA2).	Epoprostenol	79-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-70
16190133-6	2005	In contrast, increase in the concentrations of DGLA, AA, EPA, and DHA is much less with specific COX-2 inhibitors since they do not block the formation of eicosanoids through COX-1 pathway.	8,11,14-Eicosatrienoic Acid	47-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
16190133-2	2005	This has been attributed to their ability to inhibit endothelial COX-2 derived prostacyclin (PGI2) but not platelet COX-1 derived thromboxane A2 (TXA2).	Epoprostenol	93-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-70
16190133-3	2005	On the other hand, aspirin blocks both COX-1 and COX-2 enzymes without decreasing PGI2 but blocks TXA2 synthesis that explains its beneficial action in the prevention of coronary heart disease (CHD).	Aspirin	19-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-54
16190133-4	2005	The inhibitory action of aspirin on COX-1 and COX-2 enzymes enhances the tissue concentrations of dihomo-gamma-linolenic acid (DGLA), arachidonic acid, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).	Aspirin	25-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
16190133-6	2005	In contrast, increase in the concentrations of DGLA, AA, EPA, and DHA is much less with specific COX-2 inhibitors since they do not block the formation of eicosanoids through COX-1 pathway.	Eicosapentaenoic Acid	57-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
16190133-4	2005	The inhibitory action of aspirin on COX-1 and COX-2 enzymes enhances the tissue concentrations of dihomo-gamma-linolenic acid (DGLA), arachidonic acid, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).	8,11,14-Eicosatrienoic Acid	98-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
16190133-4	2005	The inhibitory action of aspirin on COX-1 and COX-2 enzymes enhances the tissue concentrations of dihomo-gamma-linolenic acid (DGLA), arachidonic acid, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).	8,11,14-Eicosatrienoic Acid	127-131	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
16190133-6	2005	In contrast, increase in the concentrations of DGLA, AA, EPA, and DHA is much less with specific COX-2 inhibitors since they do not block the formation of eicosanoids through COX-1 pathway.	Docosahexaenoic Acids	66-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
16190133-4	2005	The inhibitory action of aspirin on COX-1 and COX-2 enzymes enhances the tissue concentrations of dihomo-gamma-linolenic acid (DGLA), arachidonic acid, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).	Arachidonic Acid	134-150	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
16190133-7	2005	COX-2 inhibitors interfere with the formation of LXs and resolvins that have neuroprotective and cardioprotective actions.	Lipoxins	49-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
16190133-4	2005	The inhibitory action of aspirin on COX-1 and COX-2 enzymes enhances the tissue concentrations of dihomo-gamma-linolenic acid (DGLA), arachidonic acid, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).	Eicosapentaenoic Acid	152-173	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
16190133-4	2005	The inhibitory action of aspirin on COX-1 and COX-2 enzymes enhances the tissue concentrations of dihomo-gamma-linolenic acid (DGLA), arachidonic acid, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).	Eicosapentaenoic Acid	175-178	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
16190133-10	2005	This suggests that COX-2 inhibitors increase cardiovascular and stroke risk by interfering with the formation of eNO, PGI2, LXs, and resolvins and implies that combining EFAs with COX-2 inhibitors could prevent these complications.	Epoprostenol	118-122	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-24
16190133-10	2005	This suggests that COX-2 inhibitors increase cardiovascular and stroke risk by interfering with the formation of eNO, PGI2, LXs, and resolvins and implies that combining EFAs with COX-2 inhibitors could prevent these complications.	Lipoxins	124-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-24
16190133-10	2005	This suggests that COX-2 inhibitors increase cardiovascular and stroke risk by interfering with the formation of eNO, PGI2, LXs, and resolvins and implies that combining EFAs with COX-2 inhibitors could prevent these complications.	efas	170-174	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-24
15805430-3	2005	The increased prostaglandin E2 levels and the overexpression of COX-2 in colon and many other cancers provided the rationale for clinical trials with COX-2 inhibitors for cancer prevention or treatment.	Dinoprostone	14-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	150-155
15784648-1	2005	SC-236 [4-[5-(4-chlorophenyl)-3-(trifluoromethyl)-1-pyrazol-1-l] benzenesulfonamide; C16H11ClF3N3O2S] is a highly selective cyclooxygenase (COX)-2 inhibitor.	4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide	0-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	124-146
15784648-1	2005	SC-236 [4-[5-(4-chlorophenyl)-3-(trifluoromethyl)-1-pyrazol-1-l] benzenesulfonamide; C16H11ClF3N3O2S] is a highly selective cyclooxygenase (COX)-2 inhibitor.	4-[5-(4-chlorophenyl)-3-(trifluoromethyl)-1-pyrazol-1-l] benzenesulfonamide	8-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	124-146
15784648-1	2005	SC-236 [4-[5-(4-chlorophenyl)-3-(trifluoromethyl)-1-pyrazol-1-l] benzenesulfonamide; C16H11ClF3N3O2S] is a highly selective cyclooxygenase (COX)-2 inhibitor.	Ethyl 1-[4-(4-chlorophenyl)-1,3-thiazol-2-yl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate	85-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	124-146
15929069-4	2005	For this system, it is theorized that the polyethylene oxide segments of Pluronic crystallize and that the polypropylene oxide segments remain amorphous, providing a size-restricted domain in which the COX-2 drug crystallizes.	polypropylene glycol	107-126	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	202-207
16018763-9	2005	The IL-1beta-driven PGE(2) synthesis was blocked by indomethacin, a COX-1/COX-2 inhibitor, and by COX-2 inhibitor NS-398.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	114-120	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-103
16018763-9	2005	The IL-1beta-driven PGE(2) synthesis was blocked by indomethacin, a COX-1/COX-2 inhibitor, and by COX-2 inhibitor NS-398.	Dinoprostone	20-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
16018763-10	2005	The expression of COX-2 protein was slightly induced by glycine, more evidently by IL-1beta, and mostly enhanced by combined IL-1beta with glycine.	Glycine	56-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-23
16018763-9	2005	The IL-1beta-driven PGE(2) synthesis was blocked by indomethacin, a COX-1/COX-2 inhibitor, and by COX-2 inhibitor NS-398.	Dinoprostone	20-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-103
16018763-9	2005	The IL-1beta-driven PGE(2) synthesis was blocked by indomethacin, a COX-1/COX-2 inhibitor, and by COX-2 inhibitor NS-398.	Indomethacin	52-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
16018763-10	2005	The expression of COX-2 protein was slightly induced by glycine, more evidently by IL-1beta, and mostly enhanced by combined IL-1beta with glycine.	Glycine	139-146	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-23
16018763-11	2005	CONCLUSION: Since PGE(2) is a potent stimulator of bone resorption, and production of PGE(2) and COX-2 protein is augmented by glycine, our results strongly suggest that glycine may be involved in the pathogenesis of periodontitis.	Glycine	127-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
16018763-11	2005	CONCLUSION: Since PGE(2) is a potent stimulator of bone resorption, and production of PGE(2) and COX-2 protein is augmented by glycine, our results strongly suggest that glycine may be involved in the pathogenesis of periodontitis.	Glycine	170-177	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
15990700-2	2005	In contrast, aspirin blocks both COX-1 and COX-2 enzymes that, in turn, increases intracellular concentrations of dihomo-gamma-linolenic acid (DGLA), arachidonic acid (AA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) and reduced formation of eicosanoids.	Eicosanoids	257-268	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
15990700-0	2005	COX-2 inhibitors and metabolism of essential fatty acids.	Fatty Acids, Essential	35-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
15990700-1	2005	Selective COX-2 inhibitors increase the risk of myocardial infarction and stroke that is attributed to their ability to inhibit prostacyclin (PGI2), lipoxins, resolvins, and endothelial nitric oxide (eNO) but not platelet COX-1 derived thromboxane A2 (TXA2).	Epoprostenol	128-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
16012420-13	2005	The altered balance between prostacyclin and thromboxane, due to selective inhibition of COX-2 without reducing COX-1, could promote a prothrombotic state and explain the observed increased cardiovascular risk.	Epoprostenol	28-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-94
15990700-1	2005	Selective COX-2 inhibitors increase the risk of myocardial infarction and stroke that is attributed to their ability to inhibit prostacyclin (PGI2), lipoxins, resolvins, and endothelial nitric oxide (eNO) but not platelet COX-1 derived thromboxane A2 (TXA2).	Epoprostenol	142-146	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
15990700-1	2005	Selective COX-2 inhibitors increase the risk of myocardial infarction and stroke that is attributed to their ability to inhibit prostacyclin (PGI2), lipoxins, resolvins, and endothelial nitric oxide (eNO) but not platelet COX-1 derived thromboxane A2 (TXA2).	Lipoxins	149-157	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
15990700-1	2005	Selective COX-2 inhibitors increase the risk of myocardial infarction and stroke that is attributed to their ability to inhibit prostacyclin (PGI2), lipoxins, resolvins, and endothelial nitric oxide (eNO) but not platelet COX-1 derived thromboxane A2 (TXA2).	Nitric Oxide	186-198	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
15990700-1	2005	Selective COX-2 inhibitors increase the risk of myocardial infarction and stroke that is attributed to their ability to inhibit prostacyclin (PGI2), lipoxins, resolvins, and endothelial nitric oxide (eNO) but not platelet COX-1 derived thromboxane A2 (TXA2).	Thromboxane A2	236-250	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
15990700-2	2005	In contrast, aspirin blocks both COX-1 and COX-2 enzymes that, in turn, increases intracellular concentrations of dihomo-gamma-linolenic acid (DGLA), arachidonic acid (AA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) and reduced formation of eicosanoids.	Aspirin	13-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
15990700-2	2005	In contrast, aspirin blocks both COX-1 and COX-2 enzymes that, in turn, increases intracellular concentrations of dihomo-gamma-linolenic acid (DGLA), arachidonic acid (AA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) and reduced formation of eicosanoids.	8,11,14-Eicosatrienoic Acid	114-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
15990700-2	2005	In contrast, aspirin blocks both COX-1 and COX-2 enzymes that, in turn, increases intracellular concentrations of dihomo-gamma-linolenic acid (DGLA), arachidonic acid (AA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) and reduced formation of eicosanoids.	8,11,14-Eicosatrienoic Acid	143-147	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
16012420-13	2005	The altered balance between prostacyclin and thromboxane, due to selective inhibition of COX-2 without reducing COX-1, could promote a prothrombotic state and explain the observed increased cardiovascular risk.	Thromboxanes	45-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-94
15990700-2	2005	In contrast, aspirin blocks both COX-1 and COX-2 enzymes that, in turn, increases intracellular concentrations of dihomo-gamma-linolenic acid (DGLA), arachidonic acid (AA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) and reduced formation of eicosanoids.	Eicosapentaenoic Acid	173-194	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
15821150-5	2005	At low concentrations (&lt;0.1 microM), 15d-PGJ(2) inhibited IL-1beta-stimulated prostaglandin E(2) (PGE(2)) but not cytokine (IL-6/IL-8) production or cyclooxygenase-2 (COX-2) expression.	15d-pgj	40-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	170-175
15990700-2	2005	In contrast, aspirin blocks both COX-1 and COX-2 enzymes that, in turn, increases intracellular concentrations of dihomo-gamma-linolenic acid (DGLA), arachidonic acid (AA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) and reduced formation of eicosanoids.	Eicosapentaenoic Acid	196-199	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
15990700-2	2005	In contrast, aspirin blocks both COX-1 and COX-2 enzymes that, in turn, increases intracellular concentrations of dihomo-gamma-linolenic acid (DGLA), arachidonic acid (AA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) and reduced formation of eicosanoids.	Docosahexaenoic Acids	205-225	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
15990700-2	2005	In contrast, aspirin blocks both COX-1 and COX-2 enzymes that, in turn, increases intracellular concentrations of dihomo-gamma-linolenic acid (DGLA), arachidonic acid (AA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) and reduced formation of eicosanoids.	Docosahexaenoic Acids	227-230	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
16088245-1	2005	AIMS: To present patients with branch retinal vein occlusion (BRVO) and central retinal vein occlusion (CRVO) after application of rofecoxib (Vioxx), a cyclo-oxygenase (COX) 2 inhibitor.	rofecoxib	131-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-175
16088245-1	2005	AIMS: To present patients with branch retinal vein occlusion (BRVO) and central retinal vein occlusion (CRVO) after application of rofecoxib (Vioxx), a cyclo-oxygenase (COX) 2 inhibitor.	rofecoxib	142-147	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-175
15827035-2	2005	In 2001, the National Institute for Clinical Excellence (NICE) published guidance on the use of the COX-2 agents celecoxib, rofecoxib, meloxicam and etodolac for rheumatoid arthritis (RA) and osteoarthritis (OA).	Celecoxib	113-122	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-105
15827035-2	2005	In 2001, the National Institute for Clinical Excellence (NICE) published guidance on the use of the COX-2 agents celecoxib, rofecoxib, meloxicam and etodolac for rheumatoid arthritis (RA) and osteoarthritis (OA).	Meloxicam	135-144	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-105
15855183-9	2005	Indeed, recent investigations have shown that COX-2 inhibition, as determined by modelling of prostaglandin E2 (PGE2) levels in the whole blood assay in vitro can be used as a marker to predict drug effects (analgesia) in humans.	Dinoprostone	94-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
15855183-9	2005	Indeed, recent investigations have shown that COX-2 inhibition, as determined by modelling of prostaglandin E2 (PGE2) levels in the whole blood assay in vitro can be used as a marker to predict drug effects (analgesia) in humans.	Dinoprostone	112-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
15911396-0	2005	UV-vis spectroscopic study of Co(II)/Co(III) oxidation in poly[M-protoporphyrins] films and their interaction with axial ligands.	poly[m-protoporphyrins	58-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-36
16000872-10	2005	These results collectively suggest that curcumin may inhibit COX- 2 expression by suppressing p38 MAPK and JNK activities in UVB-irradiated HaCaT cells.	Curcumin	40-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-67
15911101-7	2005	Curcumin determined early changes in COX-2 and c-myc mRNAs, which were down-regulated, and in livin mRNA, which was up-regulated.	Curcumin	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-42
15861417-5	2005	RESULTS: Aspirin inhibited constitutive NF-kappaB activity in culture and, in turn, decreased the expression of the NF-kappaB downstream target gene, Cox-2, in PANC-1 or PANC-1/Puro cells, without significantly inhibiting the in vitro growth of PANC-1/Puro cells.	Aspirin	9-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	150-155
15688382-7	2005	Incubation of HCA-7 cancer cells for 24-96 hr with either stilbene derivative (1-50 microM) decreased prostaglandin E-2 (PGE-2) production, but only resveratrol decreased COX-2 protein expression.	Resveratrol	149-160	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	171-176
15665045-3	2005	This report describes the differential abilities of CS and AS to directly upregulate the early inflammatory mediator COX-2, the recently identified prostaglandin E (PGE) synthase and the downstream mediator PGE2 in primary human lung fibroblasts.	Cesium	52-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-122
15665045-3	2005	This report describes the differential abilities of CS and AS to directly upregulate the early inflammatory mediator COX-2, the recently identified prostaglandin E (PGE) synthase and the downstream mediator PGE2 in primary human lung fibroblasts.	Arsenic	59-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-122
15665045-6	2005	Similarly, downstream of COX-2, production of the antifibrotic prostaglandin PGE2 was induced in a dose-dependent fashion, but AS was significantly more potent (maximal production: CS = 4,710 pg/ml and AS = 7,651 pg/ml).	Prostaglandins	63-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-30
15665045-6	2005	Similarly, downstream of COX-2, production of the antifibrotic prostaglandin PGE2 was induced in a dose-dependent fashion, but AS was significantly more potent (maximal production: CS = 4,710 pg/ml and AS = 7,651 pg/ml).	Dinoprostone	77-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-30
15665045-7	2005	These increases in COX-2 and PGE2 were preceded by induction of the PGE2 synthase protein, demonstrating the potential role of this novel molecule in silica-mediated inflammation.	Silicon Dioxide	150-156	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-24
15665045-9	2005	Using specific COX-2 inhibitors, we showed increased PG production to be dependent on the COX-2 enzyme.	Prostaglandins	53-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-20
15665045-9	2005	Using specific COX-2 inhibitors, we showed increased PG production to be dependent on the COX-2 enzyme.	Prostaglandins	53-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-95
15953441-3	2005	Results of treating 24 cases of diffuse anterior scleritis with the novel selective COX-2 inhibitor celecoxib are reported.	Celecoxib	100-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-89
15846114-3	2005	COX-2 expression was measured by quantitative RT-PCR in biopsies from a series of 14 esophageal carcinomas, six of which had paired samples taken before and after chemotherapy, and in tumor-derived cells exposed to 5-FU in vitro from a series of 44 tumors, including breast, ovarian, esophageal and colonic carcinomas.	Fluorouracil	215-219	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
15846114-4	2005	COX-2 expression was increased by exposure to 5-FU or 5-FU combination chemotherapy in all the tumor types studied, whether measured in biopsies taken before and after 5-FU-based chemotherapy (4-fold increase, p&lt;0.015) or in primary cells exposed to drugs in vitro (24-fold increase, p&lt;0.001).	Fluorouracil	46-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
15846114-4	2005	COX-2 expression was increased by exposure to 5-FU or 5-FU combination chemotherapy in all the tumor types studied, whether measured in biopsies taken before and after 5-FU-based chemotherapy (4-fold increase, p&lt;0.015) or in primary cells exposed to drugs in vitro (24-fold increase, p&lt;0.001).	Fluorouracil	54-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
15846114-4	2005	COX-2 expression was increased by exposure to 5-FU or 5-FU combination chemotherapy in all the tumor types studied, whether measured in biopsies taken before and after 5-FU-based chemotherapy (4-fold increase, p&lt;0.015) or in primary cells exposed to drugs in vitro (24-fold increase, p&lt;0.001).	Fluorouracil	54-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
15846114-5	2005	A modest increase of COX-2 mRNA was also seen after in vitro treatment of cells with cisplatin.	Cisplatin	85-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-26
15846114-6	2005	In contrast, doxorubicin and paclitaxel caused no up-regulation in vitro, while irinotecan caused inhibition of COX-2 (2.7-fold decrease, p&lt;0.01).	Irinotecan	80-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-117
15778740-6	2005	HNE modification and IkappaB phosphorylation, NF-kappaB translocation to the nucleus, and following COX-2 production were inhibited by extracellular Ca(2+) removal or Gd(3+) application, as well as by the antioxidants.	ganglioside, GD3	167-173	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-105
15936346-1	2005	Prostaglandin endoperoxide synthases (PTGS), commonly referred to as cyclooxygenases (COX-1 and COX-2), catalyze the key step in the synthesis of biologically active prostaglandins (PGs), the conversion of arachidonic acid (AA) into prostaglandin H2 (PGH2).	Prostaglandins	166-180	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-101
15936346-1	2005	Prostaglandin endoperoxide synthases (PTGS), commonly referred to as cyclooxygenases (COX-1 and COX-2), catalyze the key step in the synthesis of biologically active prostaglandins (PGs), the conversion of arachidonic acid (AA) into prostaglandin H2 (PGH2).	Prostaglandins	182-185	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-101
15936346-1	2005	Prostaglandin endoperoxide synthases (PTGS), commonly referred to as cyclooxygenases (COX-1 and COX-2), catalyze the key step in the synthesis of biologically active prostaglandins (PGs), the conversion of arachidonic acid (AA) into prostaglandin H2 (PGH2).	Arachidonic Acid	206-222	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-101
15936346-1	2005	Prostaglandin endoperoxide synthases (PTGS), commonly referred to as cyclooxygenases (COX-1 and COX-2), catalyze the key step in the synthesis of biologically active prostaglandins (PGs), the conversion of arachidonic acid (AA) into prostaglandin H2 (PGH2).	Prostaglandin H2	233-249	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-101
15936346-1	2005	Prostaglandin endoperoxide synthases (PTGS), commonly referred to as cyclooxygenases (COX-1 and COX-2), catalyze the key step in the synthesis of biologically active prostaglandins (PGs), the conversion of arachidonic acid (AA) into prostaglandin H2 (PGH2).	Prostaglandin H2	251-255	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-101
15887009-0	2005	The effect of mild and moderate hepatic impairment on the pharmacokinetics of valdecoxib, a selective COX-2 inhibitor.	valdecoxib	78-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-107
15911218-4	2005	In contrast, naproxen (a non-selective NSAID) and rofecoxib (a selective inhibitor of COX-2), did not affect HO-1 expression.	rofecoxib	50-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-91
15995627-8	2005	CONCLUSION: Our data suggested that PGE2 up-regulates VEGF expression in gastric cancer cells via transactivation of EGFR-MAPK signaling pathways, which may be mechanisms underlying the contribution of COX-2 to tumor angiogenesis in gastric cancer.	Dinoprostone	36-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	202-207
15948687-1	2005	BACKGROUND: Prostaglandin E2 (PGE2), which exerts its actions via EP receptors (EP1, EP2, EP3, and EP4), is a bioactive metabolite produced by cyclooxygenase (COX)-1 and/or COX-2 from arachidonic acid.	Dinoprostone	12-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	173-178
15821150-7	2005	At higher concentrations (1-10 microM), 15d-PGJ(2) inhibited IL-1beta-stimulated PGE(2) and cytokine production and COX-2 expression, and this effect was not blocked by GW9662.	15d-pgj	40-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-121
15950656-8	2005	Raloxifene, at 0.1-10 nM, increased the mRNA expression of COX-1 and the protein content of both COX-1 as well as COX-2.	Raloxifene Hydrochloride	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-119
15950656-10	2005	Although treatment with either the selective COX-1 inhibitor SC-560 or the selective COX-2 inhibitor NS-398 significantly diminished prostacyclin release (20% +/- 5% and 24% +/- 7%, respectively), co-treatment with raloxifene and either SC-560 or NS-398 was followed by a smaller increase than that achieved by raloxifene alone.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	101-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-90
15950656-10	2005	Although treatment with either the selective COX-1 inhibitor SC-560 or the selective COX-2 inhibitor NS-398 significantly diminished prostacyclin release (20% +/- 5% and 24% +/- 7%, respectively), co-treatment with raloxifene and either SC-560 or NS-398 was followed by a smaller increase than that achieved by raloxifene alone.	Epoprostenol	133-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-90
15950656-12	2005	CONCLUSION(S): Raloxifene increased HUVEC prostacyclin release through a mechanism possibly distinct from the classical ER pathway and involving enhanced COX-1 and COX-2 expression and activity.	Raloxifene Hydrochloride	15-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	164-169
15734756-9	2005	CONCLUSIONS: Our results support the hypothesis that progesterone and MPA increased HUVEC prostacyclin production in a progesterone receptor-dependent manner, by enhancing COX-1 and COX-2 expression and activities.	Epoprostenol	90-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	182-187
15940133-6	2005	RESULTS: COX-2 mRNA and PGE 2 concentrations were similar in the CRS and NM groups but significantly decreased in nasal polyp tissue, especially in the CRS-ASNP group.	3-cresol	65-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	9-14
15940133-6	2005	RESULTS: COX-2 mRNA and PGE 2 concentrations were similar in the CRS and NM groups but significantly decreased in nasal polyp tissue, especially in the CRS-ASNP group.	3-cresol	152-155	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	9-14
15940133-6	2005	RESULTS: COX-2 mRNA and PGE 2 concentrations were similar in the CRS and NM groups but significantly decreased in nasal polyp tissue, especially in the CRS-ASNP group.	asnp	156-160	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	9-14
15948687-11	2005	CONCLUSIONS: These data suggest that COX-2-dependent PGE2 downregulates IL-1alpha-elicited MMP-3 production by cAMP-dependent pathways via EP2/EP4 receptors in human PDL cells.	Dinoprostone	53-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-42
15948687-11	2005	CONCLUSIONS: These data suggest that COX-2-dependent PGE2 downregulates IL-1alpha-elicited MMP-3 production by cAMP-dependent pathways via EP2/EP4 receptors in human PDL cells.	Cyclic AMP	111-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-42
15946639-1	2005	Augmentation, by CO(2)/HCO(3)(-), of Co(II)-catalyzed peroxidations was explored to clarify whether the rate enhancement was due to CO(2) or to HCO(3)(-).	co(2)	17-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-42
15946639-1	2005	Augmentation, by CO(2)/HCO(3)(-), of Co(II)-catalyzed peroxidations was explored to clarify whether the rate enhancement was due to CO(2) or to HCO(3)(-).	Bicarbonates	23-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-42
15946639-2	2005	The rate of oxidation of NADH by Co(II) plus H(2)O(2), in Tris or phosphate, was markedly enhanced by CO(2)/HCO(3)(-).	NAD	25-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-39
15946639-2	2005	The rate of oxidation of NADH by Co(II) plus H(2)O(2), in Tris or phosphate, was markedly enhanced by CO(2)/HCO(3)(-).	Tromethamine	58-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-39
15946639-2	2005	The rate of oxidation of NADH by Co(II) plus H(2)O(2), in Tris or phosphate, was markedly enhanced by CO(2)/HCO(3)(-).	Phosphates	66-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-39
15946639-2	2005	The rate of oxidation of NADH by Co(II) plus H(2)O(2), in Tris or phosphate, was markedly enhanced by CO(2)/HCO(3)(-).	co(2)	102-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-39
15946639-2	2005	The rate of oxidation of NADH by Co(II) plus H(2)O(2), in Tris or phosphate, was markedly enhanced by CO(2)/HCO(3)(-).	Bicarbonates	108-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-39
15946639-3	2005	Phosphate was seen to inhibit the Co(II)-catalyzed peroxidation, probably due to its sequestration of the Co(II).	Phosphates	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-39
15946639-3	2005	Phosphate was seen to inhibit the Co(II)-catalyzed peroxidation, probably due to its sequestration of the Co(II).	Phosphates	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-40
15946639-6	2005	Both kinetic and spectral data indicated that Co(II) was converted by H(2)O(2) into a less active form from which Co(II) could be regenerated.	Hydrogen Peroxide	70-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-52
15946639-6	2005	Both kinetic and spectral data indicated that Co(II) was converted by H(2)O(2) into a less active form from which Co(II) could be regenerated.	Hydrogen Peroxide	70-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-120
15948687-1	2005	BACKGROUND: Prostaglandin E2 (PGE2), which exerts its actions via EP receptors (EP1, EP2, EP3, and EP4), is a bioactive metabolite produced by cyclooxygenase (COX)-1 and/or COX-2 from arachidonic acid.	Dinoprostone	30-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	173-178
15948687-1	2005	BACKGROUND: Prostaglandin E2 (PGE2), which exerts its actions via EP receptors (EP1, EP2, EP3, and EP4), is a bioactive metabolite produced by cyclooxygenase (COX)-1 and/or COX-2 from arachidonic acid.	Arachidonic Acid	184-200	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	173-178
29539150-1	2005	BACKGROUND: Prostaglandin E2 (PGE2 ), which exerts its actions via EP receptors (EP1 , EP2 , EP3 , and EP4 ), is a bioactive metabolite produced by cyclooxygenase (COX)-1 and/or COX-2 from arachidonic acid.	Dinoprostone	12-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	178-183
15948687-2	2005	In the present study, we investigated whether COX-2-derived PGE2 regulated matrix metalloproteinase (MMP)-3 production in human periodontal ligament (PDL) cells stimulated with interleukin (IL)-1alpha and which EP receptors were involved in PGE2 regulation of IL-1alpha-induced MMP-3 production.	Dinoprostone	60-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
29539150-1	2005	BACKGROUND: Prostaglandin E2 (PGE2 ), which exerts its actions via EP receptors (EP1 , EP2 , EP3 , and EP4 ), is a bioactive metabolite produced by cyclooxygenase (COX)-1 and/or COX-2 from arachidonic acid.	Dinoprostone	30-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	178-183
29539150-1	2005	BACKGROUND: Prostaglandin E2 (PGE2 ), which exerts its actions via EP receptors (EP1 , EP2 , EP3 , and EP4 ), is a bioactive metabolite produced by cyclooxygenase (COX)-1 and/or COX-2 from arachidonic acid.	Arachidonic Acid	189-205	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	178-183
15948687-2	2005	In the present study, we investigated whether COX-2-derived PGE2 regulated matrix metalloproteinase (MMP)-3 production in human periodontal ligament (PDL) cells stimulated with interleukin (IL)-1alpha and which EP receptors were involved in PGE2 regulation of IL-1alpha-induced MMP-3 production.	Dinoprostone	241-245	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
29539150-2	2005	In the present study, we investigated whether COX-2-derived PGE2 regulated matrix metalloproteinase (MMP)-3 production in human periodontal ligament (PDL) cells stimulated with interleukin (IL)-1alpha and which EP receptors were involved in PGE2 regulation of IL-1alpha-induced MMP-3 production.	Dinoprostone	60-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
29539150-11	2005	CONCLUSIONS: These data suggest that COX-2-dependent PGE2 downregulates IL-1alpha-elicited MMP-3 production by cAMP-dependent pathways via EP2 /EP4 receptors in human PDL cells.	Dinoprostone	53-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-42
29539150-2	2005	In the present study, we investigated whether COX-2-derived PGE2 regulated matrix metalloproteinase (MMP)-3 production in human periodontal ligament (PDL) cells stimulated with interleukin (IL)-1alpha and which EP receptors were involved in PGE2 regulation of IL-1alpha-induced MMP-3 production.	Dinoprostone	241-245	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
29539150-11	2005	CONCLUSIONS: These data suggest that COX-2-dependent PGE2 downregulates IL-1alpha-elicited MMP-3 production by cAMP-dependent pathways via EP2 /EP4 receptors in human PDL cells.	Cyclic AMP	111-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-42
15772294-1	2005	Transcriptional activation of the cyclooxygenase (COX)-2 gene is responsible for high level of prostaglandin production during inflammation and carcinogenesis.	Prostaglandins	95-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-56
15755849-3	2005	In addition to its role in driving inflammation, COX-2 may also synthesize 15-deoxy-Delta (12, 14)-prostaglandin J(2) (15d-PGJ(2)), an antiinflammatory cyclopentenone prostaglandin (cyPG), which acts in some cells as an agonist of peroxisome proliferator-activated receptors (PPARs).	15-deoxy-delta (12, 14)-prostaglandin j	75-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-54
15755849-3	2005	In addition to its role in driving inflammation, COX-2 may also synthesize 15-deoxy-Delta (12, 14)-prostaglandin J(2) (15d-PGJ(2)), an antiinflammatory cyclopentenone prostaglandin (cyPG), which acts in some cells as an agonist of peroxisome proliferator-activated receptors (PPARs).	-pgj	122-126	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-54
15755849-3	2005	In addition to its role in driving inflammation, COX-2 may also synthesize 15-deoxy-Delta (12, 14)-prostaglandin J(2) (15d-PGJ(2)), an antiinflammatory cyclopentenone prostaglandin (cyPG), which acts in some cells as an agonist of peroxisome proliferator-activated receptors (PPARs).	cyclopentenone prostaglandin	152-180	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-54
15755849-5	2005	15d-PGJ(2) inhibited NF-kappaB activity and COX-2 expression in both cell types.	15d-pgj	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-49
15755849-7	2005	This shows that, in amnion and myometrium, inhibition of NF-kappaB activity and COX-2 expression by 15d-PGJ(2) is independent of PPARs and requires the cyclopentenone ring.	15d-pgj	100-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-85
15755849-7	2005	This shows that, in amnion and myometrium, inhibition of NF-kappaB activity and COX-2 expression by 15d-PGJ(2) is independent of PPARs and requires the cyclopentenone ring.	cyclopentenone	152-166	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-85
15772294-5	2005	TAM-67, a mutant of c-Jun that lacks the N-terminal transactivation domain of c-Jun, also enhanced COX-2 promoter activity and protein expression in cells treated with EGF.	tam-67	0-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-104
16265533-2	2005	Conversely, COX2 catalyzes endothelial prostacyclin synthesis, which effectively counteracts thromboxane A2, triggering vasodilation and platelet inhibition.	Epoprostenol	39-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-16
16265533-2	2005	Conversely, COX2 catalyzes endothelial prostacyclin synthesis, which effectively counteracts thromboxane A2, triggering vasodilation and platelet inhibition.	Thromboxane A2	93-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-16
16265533-3	2005	Selective COX2 inhibitors decrease prostacyclin production, potentially disrupting homeostasis and creating a prothrombotic state.	Epoprostenol	35-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-14
15870920-6	2005	For NSCLC, the mean immunostaining scores for the prostaglandin biosynthetic pathway markers were significantly higher for cases with high count groups than low count groups for MVD, VEGF and bFGF, except COX-2 and MVD, and COX-2 and bFGF.	Prostaglandins	50-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	224-229
15742005-2	2005	Previous studies with the selective COX-2 inhibitors, rofecoxib and celecoxib, have shown that they do not alter the progression of AD.	rofecoxib	54-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-41
15742005-2	2005	Previous studies with the selective COX-2 inhibitors, rofecoxib and celecoxib, have shown that they do not alter the progression of AD.	Celecoxib	68-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-41
15829436-5	2005	We found beta-lapachone decreased the levels of cyclooxygenase (COX)-2 mRNA and protein expression without significant changes in the levels of COX-1, which was correlated with a decrease in prostaglandin E2 (PGE2) synthesis.	beta-lapachone	9-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-70
16021964-0	2005	[The selective cox-2 inhibitor meloxicam and salicylate therapy].	Meloxicam	31-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-20
15914468-5	2005	On the other hand, in inflammatory setting, the inducible isoforms of these enzymes (inducible NOS and COX-2) are detected in a variety of cells, resulting in the production of large amounts of proinflammatory and cytotoxic NO and PGs.	Prostaglandins	231-234	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-108
15981408-1	2005	(1) Evidence that the Cox-2 inhibitors have severe cardiovascular adverse effects continues to accumulate, including an increase in overall mortality in several trials of rofecoxib.	rofecoxib	171-180	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-27
14963695-0	2005	The effects of colchicine and hydroxychloroquine on the cyclo-oxygenases COX-1 and COX-2.	Colchicine	15-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
14963695-0	2005	The effects of colchicine and hydroxychloroquine on the cyclo-oxygenases COX-1 and COX-2.	Hydroxychloroquine	30-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
15833659-0	2005	Metal ion promoted hydrogels for bovine serum albumin adsorption: Cu(II) and Co(II) chelated poly[(N-vinylimidazole)-maleic acid].	Metals	0-5	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-83
15877418-3	2005	The ferromagnetic Co(3)O(14) triangular cluster core consists of three octahedrally oxo-coordinated Co(II) ions sharing edges.	co(3)	18-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-106
15833659-0	2005	Metal ion promoted hydrogels for bovine serum albumin adsorption: Cu(II) and Co(II) chelated poly[(N-vinylimidazole)-maleic acid].	poly[(n-vinylimidazole)-maleic acid	93-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-83
15833659-4	2005	The swelling ratios of the gels were 1200% for poly(VIm-MA), 60 and 45% for Cu(II) and Co(II)-chelated poly(VIm-MA) gels at pH=5.0 in acetate buffer solution.	poly(vim-ma)	103-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-92
15833659-4	2005	The swelling ratios of the gels were 1200% for poly(VIm-MA), 60 and 45% for Cu(II) and Co(II)-chelated poly(VIm-MA) gels at pH=5.0 in acetate buffer solution.	Acetates	134-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-92
15833659-5	2005	These affinity gels with different swelling ratios for plain poly(VIm-MA), Cu(II)-, and Co(II)-chelated poly(VIm-MA), in acetate and phosphate buffers were used in the bovine serum albumin (BSA) adsorption/desorption studies in batch reactor.	poly	104-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-94
15833659-5	2005	These affinity gels with different swelling ratios for plain poly(VIm-MA), Cu(II)-, and Co(II)-chelated poly(VIm-MA), in acetate and phosphate buffers were used in the bovine serum albumin (BSA) adsorption/desorption studies in batch reactor.	vim-ma	109-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-94
15857149-1	2005	A small set of substituted 1,5-diarylpyrrole-3-acetic and -glyoxylic acid derivatives have been synthesized, and their cyclooxygenase (COX-1 and COX-2) inhibiting properties have been evaluated.	1,5-diarylpyrrole-3-acetic and -glyoxylic acid	27-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-150
15965068-5	2005	We report here that a COX-2 selective NSAID, celecoxib, induced a concentration- and time-dependent increase of HO-1 expression in glomerular mesangial cells.	Celecoxib	45-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-27
15842575-0	2005	Improvements with esomeprazole in patients with upper gastrointestinal symptoms taking non-steroidal antiinflammatory drugs, including selective COX-2 inhibitors.	Esomeprazole	18-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-150
15842575-8	2005	Esomeprazole-improved symptoms in patients taking selective COX-2 inhibitors, with changes of 2.21 [1.46] and 1.92 [1.38]versus 1.64 [1.46] in NASA1 and 2.20 [1.26] and 2.24 [1.62]versus 1.58 [1.37] in SPACE1 (all placebo comparisons at least p &lt; 0.05), as well as those on non-selective NSAIDs.	Esomeprazole	0-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-65
15842575-10	2005	CONCLUSION: Esomeprazole 20 mg and 40 mg improve upper GI symptoms associated with continuous, daily NSAID therapy, including selective COX-2 inhibitors.	Esomeprazole	12-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	136-141
15845674-0	2005	Changing role of COX-2 inhibitors in the perioperative period: is parecoxib really the answer?	parecoxib	66-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22
15867369-11	2005	In contrast, the COX-2-selective inhibitor celecoxib had little effect on tumor growth.	Celecoxib	43-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22
16053662-0	2005	Targeting COX-2/PG-E2 with a COX-2 inhibitor in combination with chemotherapy for non-small cell lung cancer: are we ready for phase III?	Dinoprostone	16-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34
15867369-2	2005	Cyclooxygenases (COX-1 and COX-2) catalyze the conversion of arachidonic acid to prostaglandins.	Arachidonic Acid	61-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-32
15867369-2	2005	Cyclooxygenases (COX-1 and COX-2) catalyze the conversion of arachidonic acid to prostaglandins.	Prostaglandins	81-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-32
15909599-13	2005	After cessation of COX-2 inhibitor treatment, patients recovered completely with a normalized serum creatinine level after one to two months.	Creatinine	100-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-24
15867233-2	2005	Our study was designed to determine whether the COX-2 inhibitor celecoxib could be safely administered in doses within those approved by the Food and Drug Administration when used concurrently with thoracic radiotherapy in patients with poor prognosis non-small cell lung cancer (NSCLC).	Celecoxib	64-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-53
15974563-2	2005	Etoricoxib, a COX-2 specific inhibitor, was developed to provide similar efficacy and less GI toxicity than non-selective NSAIDs.	Etoricoxib	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
15934855-1	2005	Like all COX-2 inhibitors, rofecoxib has been developed based on the hypothesis that at comparable therapeutic efficacy, it would have a better safety and tolerability profile than conventional NSAIDs.	rofecoxib	27-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	9-14
15912958-0	2005	Possible anti-inflammatory role of COX-2-derived prostaglandins: implications for inflammation research.	Prostaglandins	49-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40
15831902-6	2005	Indomethacin (COX-1/COX-2 inhibitor), SC-560 (COX-1 inhibitor), or DFU (COX-2 inhibitor) enhanced atropine sensitive electrically induced contractions of human longitudinal muscle.	5,5-dimethyl-3-(3-fluorophenyl)-4-(4-methylsulfonyl)phenyl-2(5H)-furanone	67-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
20477653-0	2005	Lumiracoxib, a highly selective COX-2 inhibitor.	lumiracoxib	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-37
15831902-6	2005	Indomethacin (COX-1/COX-2 inhibitor), SC-560 (COX-1 inhibitor), or DFU (COX-2 inhibitor) enhanced atropine sensitive electrically induced contractions of human longitudinal muscle.	Atropine	98-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-25
15831902-6	2005	Indomethacin (COX-1/COX-2 inhibitor), SC-560 (COX-1 inhibitor), or DFU (COX-2 inhibitor) enhanced atropine sensitive electrically induced contractions of human longitudinal muscle.	Atropine	98-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
16019514-4	2005	In our study, a potent COX2 inhibitor, nabumetone (NBT), was investigated for its anti-proliferative and apoptotic effects in K-562 and Meg-01 chronic myeloid leukemia blastic cell lines as a single agent or in combination with adriamycin (ADR) and interferon alpha (IFN-a).	Nabumetone	39-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-27
15887126-4	2005	Prostaglandins and other eicosanoids derived from COX-1 and COX-2 are involved in a variety of physiologic and pathologic processes in the gastrointestinal tract.	Prostaglandins	0-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-65
15887126-4	2005	Prostaglandins and other eicosanoids derived from COX-1 and COX-2 are involved in a variety of physiologic and pathologic processes in the gastrointestinal tract.	Eicosanoids	25-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-65
15887126-5	2005	Recent efforts to identify the molecular mechanisms by which COX-2-derived prostanoids exert their proneoplastic effects have provided a rationale for the possible use of NSAIDs alone or in a combination with conventional or experimental anticancer agents for the treatment or prevention of gastrointestinal cancers.	Prostaglandins	75-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-66
15687328-3	2005	Our hypothesis is that higher levels of COX-2 expression result in higher levels of prostaglandin E2, which, in turn, increases CYP19 expression through increases in intracellular cAMP levels.	Dinoprostone	84-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
15687328-3	2005	Our hypothesis is that higher levels of COX-2 expression result in higher levels of prostaglandin E2, which, in turn, increases CYP19 expression through increases in intracellular cAMP levels.	Cyclic AMP	180-184	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
15829319-3	2005	COX-2, which catalyzes the first step in the synthesis of prostanoids, has been shown to be overexpressed in tumors.	Prostaglandins	58-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
16019514-4	2005	In our study, a potent COX2 inhibitor, nabumetone (NBT), was investigated for its anti-proliferative and apoptotic effects in K-562 and Meg-01 chronic myeloid leukemia blastic cell lines as a single agent or in combination with adriamycin (ADR) and interferon alpha (IFN-a).	Nabumetone	51-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-27
15700047-0	2005	Inhibition of COX-2 by celecoxib enhances glucocorticoid receptor function.	Celecoxib	23-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
15870622-13	2005	CONCLUSION: This study has confirmed that selective and nonselective COX inhibition can induce significant inhibition of free water clearance, indicating that these acute changes are regulated predominantly via COX-2.	Water	126-131	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	211-216
15779068-7	2005	TAS reduced mRNA levels of COX-2, TNF-alpha, IL-8, IL-6, and IL-1alpha, while resveratrol impaired early expression of IL-8 and TNF-alpha.	tas	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-32
15834426-3	2005	Among the more potent Abeta42-raising agents identified are fenofibrate, an antilipidemic agent, and celecoxib, a COX-2-selective NSAID.	Celecoxib	101-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-119
15899741-5	2005	However, only two of these reports involved renal transplant recipients, and in both, rofecoxib was the COX-2 inhibitor of concern.	rofecoxib	86-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
15999628-0	2005	[The medical reason for the prescription of COX-2 selective cyclo oxygenase inhibitor rofecoxib for the treatment of rheumatoid arthritis.	rofecoxib	86-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-49
15879708-4	2005	When extracellular pH ([pH]o) was reduced to pH 6.4, COX-2 mRNA increased, with a peak at 2 h. This was blocked by pretreatment with actinomycin D and incubation with spermine NONOate (SPER/NO, a nitric oxide donor).	Dactinomycin	133-146	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-58
16111045-1	2005	OBJECTIVE: To study the effects of c9, t11-conjugated linoleic acid (c9, t11-CLA) on the critical enzyme (COX-2) and its product - prostaglandin E2 (PGE2) of linoleic acid metabolism path in human gastric adenocarcinoma cell line (SGC-7901).	Linoleic Acid	54-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-111
16111045-1	2005	OBJECTIVE: To study the effects of c9, t11-conjugated linoleic acid (c9, t11-CLA) on the critical enzyme (COX-2) and its product - prostaglandin E2 (PGE2) of linoleic acid metabolism path in human gastric adenocarcinoma cell line (SGC-7901).	Dinoprostone	131-147	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-111
16111045-1	2005	OBJECTIVE: To study the effects of c9, t11-conjugated linoleic acid (c9, t11-CLA) on the critical enzyme (COX-2) and its product - prostaglandin E2 (PGE2) of linoleic acid metabolism path in human gastric adenocarcinoma cell line (SGC-7901).	Dinoprostone	149-153	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-111
16111045-1	2005	OBJECTIVE: To study the effects of c9, t11-conjugated linoleic acid (c9, t11-CLA) on the critical enzyme (COX-2) and its product - prostaglandin E2 (PGE2) of linoleic acid metabolism path in human gastric adenocarcinoma cell line (SGC-7901).	Linoleic Acid	158-171	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-111
15879708-4	2005	When extracellular pH ([pH]o) was reduced to pH 6.4, COX-2 mRNA increased, with a peak at 2 h. This was blocked by pretreatment with actinomycin D and incubation with spermine NONOate (SPER/NO, a nitric oxide donor).	spermine nitric oxide complex	167-183	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-58
15879708-4	2005	When extracellular pH ([pH]o) was reduced to pH 6.4, COX-2 mRNA increased, with a peak at 2 h. This was blocked by pretreatment with actinomycin D and incubation with spermine NONOate (SPER/NO, a nitric oxide donor).	sper	185-189	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-58
15879708-4	2005	When extracellular pH ([pH]o) was reduced to pH 6.4, COX-2 mRNA increased, with a peak at 2 h. This was blocked by pretreatment with actinomycin D and incubation with spermine NONOate (SPER/NO, a nitric oxide donor).	Nitric Oxide	196-208	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-58
15879708-5	2005	Exposure to the H+ ionophore, carbonyl cyanide m-chlorophenylhydrazone (CCCP), also raised COX-2 mRNA levels.	Carbonyl Cyanide m-Chlorophenyl Hydrazone	30-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-96
15879708-5	2005	Exposure to the H+ ionophore, carbonyl cyanide m-chlorophenylhydrazone (CCCP), also raised COX-2 mRNA levels.	Carbonyl Cyanide m-Chlorophenyl Hydrazone	72-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-96
15879708-8	2005	These data demonstrate that COX-2 expression is stimulated by the lowering of extracellular pH that could result from bacterial infection, and that this is countered by over-production of nitric oxide, which could also result from bacterial infection.	Nitric Oxide	188-200	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
15713664-10	2005	C/EBPbeta-p20 markedly suppressed hypertonic (550 mOsm) induction of COX2 (immunoblot) to a similar extent as IkappaBm.	-p20	9-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-73
15837305-0	2005	Novel approach to pro-drugs of lactones: water soluble imidate and ortho-ester derivatives of a furanone-based COX-2 selective inhibitor.	Lactones	31-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	111-116
15837305-0	2005	Novel approach to pro-drugs of lactones: water soluble imidate and ortho-ester derivatives of a furanone-based COX-2 selective inhibitor.	Water	41-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	111-116
15837305-0	2005	Novel approach to pro-drugs of lactones: water soluble imidate and ortho-ester derivatives of a furanone-based COX-2 selective inhibitor.	Esters	73-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	111-116
15837305-0	2005	Novel approach to pro-drugs of lactones: water soluble imidate and ortho-ester derivatives of a furanone-based COX-2 selective inhibitor.	2(3H)-Furanone	96-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	111-116
15837305-1	2005	Interest in water soluble COX-2 inhibitors that can be administered intravenously led to the development of novel pro-drugs of a furanone based COX-2 inhibitor 2.	Water	12-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-31
15837305-1	2005	Interest in water soluble COX-2 inhibitors that can be administered intravenously led to the development of novel pro-drugs of a furanone based COX-2 inhibitor 2.	Water	12-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	144-149
15713664-12	2005	Interestingly, IKK-induced COX2 expression was not only blocked by IkappaBm, but also completely abolished by C/EBPbeta-p20.	-p20	119-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-31
15837305-1	2005	Interest in water soluble COX-2 inhibitors that can be administered intravenously led to the development of novel pro-drugs of a furanone based COX-2 inhibitor 2.	2(3H)-Furanone	129-137	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-31
15819551-3	2005	The trimeric polyanion 1 has a core of nine Co(II) ions encapsulated by three unprecedented (beta-SiW(8)O(31)) fragments and two Cl(-) ligands.	polyanion 1	13-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-50
15837305-1	2005	Interest in water soluble COX-2 inhibitors that can be administered intravenously led to the development of novel pro-drugs of a furanone based COX-2 inhibitor 2.	2(3H)-Furanone	129-137	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	144-149
15819551-4	2005	This central assembly {Co(9)Cl(2)(OH)(3)(H(2)O)(9)(beta-SiW(8)O(31))(3)}(17-) is surrounded by six antenna-like Co(II)(H(2)O)(5) groups resulting in the satellite-like structure 1.	co(9)cl	23-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-118
15843042-2	2005	In the present study, we found that 12-o-tetradecanoylphorbol 13-acetate (TPA) induced cyclooxygenase 2 (COX-2), but not COX-1, protein expression in HL-60 cells, and the addition of arachidonic acid (AA) in the presence or absence of TPA significantly reduced the viability of HL-60 cells, an effect that was blocked by adding the COX inhibitors, NS398 and aspirin.	Tetradecanoylphorbol Acetate	36-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-110
15781386-0	2005	Synthesis and biological evaluation of 3,4-diphenyl-1,2,5-oxadiazole-2-oxides and 3,4-diphenyl-1,2,5-oxadiazoles as potential hybrid COX-2 inhibitor/nitric oxide donor agents.	3,4-diphenyl-1,2,5-oxadiazole-2-oxides	39-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	133-138
15781386-0	2005	Synthesis and biological evaluation of 3,4-diphenyl-1,2,5-oxadiazole-2-oxides and 3,4-diphenyl-1,2,5-oxadiazoles as potential hybrid COX-2 inhibitor/nitric oxide donor agents.	3,4-diphenyl-1,2,5-oxadiazoles	82-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	133-138
15781386-0	2005	Synthesis and biological evaluation of 3,4-diphenyl-1,2,5-oxadiazole-2-oxides and 3,4-diphenyl-1,2,5-oxadiazoles as potential hybrid COX-2 inhibitor/nitric oxide donor agents.	Nitric Oxide	149-161	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	133-138
15781386-6	2005	Molecular modeling (docking) studies show that the methanesulfonyl (MeSO2) COX-2 pharmacophore present in regioisomers 13a,b is positioned in the vicinity of the COX-2 secondary pocket.	methanesulfonyl	51-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
15781386-6	2005	Molecular modeling (docking) studies show that the methanesulfonyl (MeSO2) COX-2 pharmacophore present in regioisomers 13a,b is positioned in the vicinity of the COX-2 secondary pocket.	methanesulfonyl	51-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	162-167
15781386-6	2005	Molecular modeling (docking) studies show that the methanesulfonyl (MeSO2) COX-2 pharmacophore present in regioisomers 13a,b is positioned in the vicinity of the COX-2 secondary pocket.	meso2	68-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
15781386-6	2005	Molecular modeling (docking) studies show that the methanesulfonyl (MeSO2) COX-2 pharmacophore present in regioisomers 13a,b is positioned in the vicinity of the COX-2 secondary pocket.	meso2	68-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	162-167
15781386-7	2005	The in vitro NO release data, COX-1/COX-2 inhibition and COX-2 SI structure-activity relationships acquired, and molecular modeling docking studies suggest that the 1,2,5-oxadiazole-2-oxide (furoxan) ring possesses beneficial features that should be present in a suitable central ring template (bioisostere) pertinent to the design novel hybrid COX-2 inhibitor/nitric oxide donor agents with a low ulcerogenicity profile that may be free from adverse cardiovascular effects.	1,2,5-oxadiazole 2-oxide	165-189	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-41
15781386-7	2005	The in vitro NO release data, COX-1/COX-2 inhibition and COX-2 SI structure-activity relationships acquired, and molecular modeling docking studies suggest that the 1,2,5-oxadiazole-2-oxide (furoxan) ring possesses beneficial features that should be present in a suitable central ring template (bioisostere) pertinent to the design novel hybrid COX-2 inhibitor/nitric oxide donor agents with a low ulcerogenicity profile that may be free from adverse cardiovascular effects.	1,2,5-oxadiazole 2-oxide	165-189	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-62
15781386-7	2005	The in vitro NO release data, COX-1/COX-2 inhibition and COX-2 SI structure-activity relationships acquired, and molecular modeling docking studies suggest that the 1,2,5-oxadiazole-2-oxide (furoxan) ring possesses beneficial features that should be present in a suitable central ring template (bioisostere) pertinent to the design novel hybrid COX-2 inhibitor/nitric oxide donor agents with a low ulcerogenicity profile that may be free from adverse cardiovascular effects.	1,2,5-oxadiazole 2-oxide	165-189	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-62
15781386-7	2005	The in vitro NO release data, COX-1/COX-2 inhibition and COX-2 SI structure-activity relationships acquired, and molecular modeling docking studies suggest that the 1,2,5-oxadiazole-2-oxide (furoxan) ring possesses beneficial features that should be present in a suitable central ring template (bioisostere) pertinent to the design novel hybrid COX-2 inhibitor/nitric oxide donor agents with a low ulcerogenicity profile that may be free from adverse cardiovascular effects.	1,2,5-oxadiazole 2-oxide	191-198	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-41
15781386-7	2005	The in vitro NO release data, COX-1/COX-2 inhibition and COX-2 SI structure-activity relationships acquired, and molecular modeling docking studies suggest that the 1,2,5-oxadiazole-2-oxide (furoxan) ring possesses beneficial features that should be present in a suitable central ring template (bioisostere) pertinent to the design novel hybrid COX-2 inhibitor/nitric oxide donor agents with a low ulcerogenicity profile that may be free from adverse cardiovascular effects.	1,2,5-oxadiazole 2-oxide	191-198	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-62
15781386-7	2005	The in vitro NO release data, COX-1/COX-2 inhibition and COX-2 SI structure-activity relationships acquired, and molecular modeling docking studies suggest that the 1,2,5-oxadiazole-2-oxide (furoxan) ring possesses beneficial features that should be present in a suitable central ring template (bioisostere) pertinent to the design novel hybrid COX-2 inhibitor/nitric oxide donor agents with a low ulcerogenicity profile that may be free from adverse cardiovascular effects.	1,2,5-oxadiazole 2-oxide	191-198	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-62
15781386-7	2005	The in vitro NO release data, COX-1/COX-2 inhibition and COX-2 SI structure-activity relationships acquired, and molecular modeling docking studies suggest that the 1,2,5-oxadiazole-2-oxide (furoxan) ring possesses beneficial features that should be present in a suitable central ring template (bioisostere) pertinent to the design novel hybrid COX-2 inhibitor/nitric oxide donor agents with a low ulcerogenicity profile that may be free from adverse cardiovascular effects.	Nitric Oxide	361-373	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-62
15781386-7	2005	The in vitro NO release data, COX-1/COX-2 inhibition and COX-2 SI structure-activity relationships acquired, and molecular modeling docking studies suggest that the 1,2,5-oxadiazole-2-oxide (furoxan) ring possesses beneficial features that should be present in a suitable central ring template (bioisostere) pertinent to the design novel hybrid COX-2 inhibitor/nitric oxide donor agents with a low ulcerogenicity profile that may be free from adverse cardiovascular effects.	Nitric Oxide	361-373	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-62
15834531-8	2005	Supposedly, the combination of tizanidine/rofecoxib used to be prescribed frequently for lumbar pain as selective cyclooxygenase-(COX-)2 inhibitors are visibly replacing the nonsteroidal antirheumatics due to their better side effect profile.	tizanidine	31-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-136
15834531-8	2005	Supposedly, the combination of tizanidine/rofecoxib used to be prescribed frequently for lumbar pain as selective cyclooxygenase-(COX-)2 inhibitors are visibly replacing the nonsteroidal antirheumatics due to their better side effect profile.	rofecoxib	42-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-136
15796554-0	2005	Modeling spin interactions in a cyclic trimer and a cuboidal Co4O4 core with Co(II) in tetrahedral and octahedral environments.	co4o4	61-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-83
15792451-1	2005	Three coordination polymers of Co(II) with dicyanamide (dca) were obtained by adding coligands of 2,5-dimethylpyrazine-dioxide (2,5-dmpdo), 2,3,5-trimethylpyrazine-dioxide (2,3,5-tmpdo), or 2,3,5,6-tetramethylpyrazine-dioxide (2,3,5,6-tmpdo) to the binary system of Co-dca.	2,3,5,6-tmpdo	227-240	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-37
15792451-1	2005	Three coordination polymers of Co(II) with dicyanamide (dca) were obtained by adding coligands of 2,5-dimethylpyrazine-dioxide (2,5-dmpdo), 2,3,5-trimethylpyrazine-dioxide (2,3,5-tmpdo), or 2,3,5,6-tetramethylpyrazine-dioxide (2,3,5,6-tmpdo) to the binary system of Co-dca.	co-dca	266-272	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-37
15563538-3	2005	Thus the inducible cyclooxygenase (COX) isoform (COX-2), assumed to play a key role in inflammation, should be involved in the synthesis of the PG that is released.	Prostaglandins	144-146	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-54
15943176-1	2005	The aim of this study was to compare the in vivo effects on free radical metabolism of 2 non-steroidal anti-inflammatory drugs (NSAIDs): tenoxicam, an oxicam preferentially cyclooxygenase-1 (COX-1) inhibitor, and celecoxib, a sulfonamide selective COX-2 inhibitor.	Free Radicals	60-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	248-253
15943176-1	2005	The aim of this study was to compare the in vivo effects on free radical metabolism of 2 non-steroidal anti-inflammatory drugs (NSAIDs): tenoxicam, an oxicam preferentially cyclooxygenase-1 (COX-1) inhibitor, and celecoxib, a sulfonamide selective COX-2 inhibitor.	tenoxicam	137-146	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	248-253
15943176-1	2005	The aim of this study was to compare the in vivo effects on free radical metabolism of 2 non-steroidal anti-inflammatory drugs (NSAIDs): tenoxicam, an oxicam preferentially cyclooxygenase-1 (COX-1) inhibitor, and celecoxib, a sulfonamide selective COX-2 inhibitor.	oxicam	140-146	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	248-253
15850674-2	2005	The initial step in the formation of prostanoids, i.e., the conversion of free arachidonic acid (AA) to prostaglandin (PG)G(2) and then to PGH(2), is controlled by two PGH synthases (COX-1 and COX-2).	Prostaglandins	37-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	193-198
15850674-2	2005	The initial step in the formation of prostanoids, i.e., the conversion of free arachidonic acid (AA) to prostaglandin (PG)G(2) and then to PGH(2), is controlled by two PGH synthases (COX-1 and COX-2).	Arachidonic Acid	79-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	193-198
15850674-2	2005	The initial step in the formation of prostanoids, i.e., the conversion of free arachidonic acid (AA) to prostaglandin (PG)G(2) and then to PGH(2), is controlled by two PGH synthases (COX-1 and COX-2).	Prostaglandins	104-117	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	193-198
15850674-2	2005	The initial step in the formation of prostanoids, i.e., the conversion of free arachidonic acid (AA) to prostaglandin (PG)G(2) and then to PGH(2), is controlled by two PGH synthases (COX-1 and COX-2).	Prostaglandins	119-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	193-198
15850674-2	2005	The initial step in the formation of prostanoids, i.e., the conversion of free arachidonic acid (AA) to prostaglandin (PG)G(2) and then to PGH(2), is controlled by two PGH synthases (COX-1 and COX-2).	GH2 protein, human	139-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	193-198
15850674-8	2005	Recently, the involvement of COX-2 in endogenous cannabinoid system has been suggested.	Cannabinoids	49-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34
15850674-9	2005	Interestingly, COX-2-mediated oxygenation of arachidonylethanolamide (anandamide, AEA) and 2-arachidonylglycerol (2-AG) provides diverse sets of novel lipids that are structurally related to prostaglandins.	anandamide	45-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-20
15850674-9	2005	Interestingly, COX-2-mediated oxygenation of arachidonylethanolamide (anandamide, AEA) and 2-arachidonylglycerol (2-AG) provides diverse sets of novel lipids that are structurally related to prostaglandins.	anandamide	70-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-20
15850674-9	2005	Interestingly, COX-2-mediated oxygenation of arachidonylethanolamide (anandamide, AEA) and 2-arachidonylglycerol (2-AG) provides diverse sets of novel lipids that are structurally related to prostaglandins.	anandamide	82-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-20
15850674-9	2005	Interestingly, COX-2-mediated oxygenation of arachidonylethanolamide (anandamide, AEA) and 2-arachidonylglycerol (2-AG) provides diverse sets of novel lipids that are structurally related to prostaglandins.	glyceryl 2-arachidonate	91-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-20
15850674-9	2005	Interestingly, COX-2-mediated oxygenation of arachidonylethanolamide (anandamide, AEA) and 2-arachidonylglycerol (2-AG) provides diverse sets of novel lipids that are structurally related to prostaglandins.	glyceryl 2-arachidonate	114-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-20
15850674-9	2005	Interestingly, COX-2-mediated oxygenation of arachidonylethanolamide (anandamide, AEA) and 2-arachidonylglycerol (2-AG) provides diverse sets of novel lipids that are structurally related to prostaglandins.	Prostaglandins	191-205	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-20
15618359-3	2005	Cyclooxygenase (COX)-2 and prostaglandin (PG)E(2), a major eicosanoid product of the COX-2-catalyzed pathway, play key roles in normal bone tissue remodeling.	Dinoprostone	27-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-90
15618359-3	2005	Cyclooxygenase (COX)-2 and prostaglandin (PG)E(2), a major eicosanoid product of the COX-2-catalyzed pathway, play key roles in normal bone tissue remodeling.	Eicosanoids	59-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-22
15618359-3	2005	Cyclooxygenase (COX)-2 and prostaglandin (PG)E(2), a major eicosanoid product of the COX-2-catalyzed pathway, play key roles in normal bone tissue remodeling.	Eicosanoids	59-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-90
15831295-11	2005	Inhibition of COX-2 by NS398 significantly reduced PGE(2) levels in both normal and adhesion fibroblasts.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	23-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
15831295-11	2005	Inhibition of COX-2 by NS398 significantly reduced PGE(2) levels in both normal and adhesion fibroblasts.	Dinoprostone	51-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
15848208-0	2005	Synthesis and biological evaluation of a new class of acyl derivatives of 3-amino-1-phenyl-4,5-dihydro-1H-pyrazol-5-one as potential dual cyclooxygenase (COX-1 and COX-2) and human lipoxygenase (5-LOX) inhibitors.	-phenyl-4,5-dihydro-1h-pyrazol-5-one	83-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	164-169
15848208-1	2005	A series of acyl derivatives of 3-amino-1-phenyl-4,5-dihydro-1H-pyrazol-5-one as potential human 5-LOX and COX 1 and COX-2 inhibitors structurally related to the 1-phenyl-3-pyrazolidinone (phenidone, 1) have been synthesized and the activity against COX-1, COX-2 and human 5-LOX enzymes has been evaluated.	3-amino-1-phenyl-4,5-dihydro-1H-pyrazol-5-one	32-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-122
15848208-1	2005	A series of acyl derivatives of 3-amino-1-phenyl-4,5-dihydro-1H-pyrazol-5-one as potential human 5-LOX and COX 1 and COX-2 inhibitors structurally related to the 1-phenyl-3-pyrazolidinone (phenidone, 1) have been synthesized and the activity against COX-1, COX-2 and human 5-LOX enzymes has been evaluated.	3-amino-1-phenyl-4,5-dihydro-1H-pyrazol-5-one	32-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	257-262
16372792-1	2005	The study is a prospective randomized double blind clinical trial comparing the efficacy of nonselective NSAIDs (Aceclofenac) and highly selective COX-2 inhibitors (Etoricoxib) in post extraction pain control.	Etoricoxib	165-175	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-152
15808467-0	2005	A general carbometalation, three component coupling strategy for the synthesis of alpha,beta-unsaturated gamma-sultines including thio-rofecoxib, a selective COX-2 inhibitor.	alpha,beta-unsaturated gamma-sultines	82-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	158-163
15808467-0	2005	A general carbometalation, three component coupling strategy for the synthesis of alpha,beta-unsaturated gamma-sultines including thio-rofecoxib, a selective COX-2 inhibitor.	thio-rofecoxib	130-144	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	158-163
15808467-2	2005	Thio-rofecoxib, a selective COX-2 inhibitor (12), is synthesized by this method and its IC(50), microM COX-1 and COX-2 inhibition, and whole blood stability values reported.	thio-rofecoxib	0-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
15808467-2	2005	Thio-rofecoxib, a selective COX-2 inhibitor (12), is synthesized by this method and its IC(50), microM COX-1 and COX-2 inhibition, and whole blood stability values reported.	thio-rofecoxib	0-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-118
15792451-1	2005	Three coordination polymers of Co(II) with dicyanamide (dca) were obtained by adding coligands of 2,5-dimethylpyrazine-dioxide (2,5-dmpdo), 2,3,5-trimethylpyrazine-dioxide (2,3,5-tmpdo), or 2,3,5,6-tetramethylpyrazine-dioxide (2,3,5,6-tmpdo) to the binary system of Co-dca.	trimethylsulfonium dicyanamide	43-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-37
15792451-1	2005	Three coordination polymers of Co(II) with dicyanamide (dca) were obtained by adding coligands of 2,5-dimethylpyrazine-dioxide (2,5-dmpdo), 2,3,5-trimethylpyrazine-dioxide (2,3,5-tmpdo), or 2,3,5,6-tetramethylpyrazine-dioxide (2,3,5,6-tmpdo) to the binary system of Co-dca.	dichloroacetylene	56-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-37
15792451-1	2005	Three coordination polymers of Co(II) with dicyanamide (dca) were obtained by adding coligands of 2,5-dimethylpyrazine-dioxide (2,5-dmpdo), 2,3,5-trimethylpyrazine-dioxide (2,3,5-tmpdo), or 2,3,5,6-tetramethylpyrazine-dioxide (2,3,5,6-tmpdo) to the binary system of Co-dca.	2,5-dimethylpyrazine-dioxide	98-126	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-37
15792451-1	2005	Three coordination polymers of Co(II) with dicyanamide (dca) were obtained by adding coligands of 2,5-dimethylpyrazine-dioxide (2,5-dmpdo), 2,3,5-trimethylpyrazine-dioxide (2,3,5-tmpdo), or 2,3,5,6-tetramethylpyrazine-dioxide (2,3,5,6-tmpdo) to the binary system of Co-dca.	2,5-dmpdo	128-137	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-37
15792451-1	2005	Three coordination polymers of Co(II) with dicyanamide (dca) were obtained by adding coligands of 2,5-dimethylpyrazine-dioxide (2,5-dmpdo), 2,3,5-trimethylpyrazine-dioxide (2,3,5-tmpdo), or 2,3,5,6-tetramethylpyrazine-dioxide (2,3,5,6-tmpdo) to the binary system of Co-dca.	2,3,5-trimethylpyrazine-dioxide	140-171	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-37
15792451-1	2005	Three coordination polymers of Co(II) with dicyanamide (dca) were obtained by adding coligands of 2,5-dimethylpyrazine-dioxide (2,5-dmpdo), 2,3,5-trimethylpyrazine-dioxide (2,3,5-tmpdo), or 2,3,5,6-tetramethylpyrazine-dioxide (2,3,5,6-tmpdo) to the binary system of Co-dca.	5-tmpdo	177-184	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-37
15792451-1	2005	Three coordination polymers of Co(II) with dicyanamide (dca) were obtained by adding coligands of 2,5-dimethylpyrazine-dioxide (2,5-dmpdo), 2,3,5-trimethylpyrazine-dioxide (2,3,5-tmpdo), or 2,3,5,6-tetramethylpyrazine-dioxide (2,3,5,6-tmpdo) to the binary system of Co-dca.	2,3,5,6-tetramethylpyrazine-dioxide	190-225	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-37
15977092-1	2005	This study was designed to test the hypothesis whether preemptive administration of rofecoxib, a novel selective COX-2 inhibitor, can prolong intraarticular bupivacaine analgesia after arthroscopic knee surgery.	rofecoxib	84-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-118
15882125-4	2005	Lumiracoxib is a novel COX-2 selective inhibitor (coxib) with improved biochemical selectivity over that of currently available coxibs.	lumiracoxib	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-28
15736048-6	2005	In contrast, treatment with L-Arg reduced the delay of the lesion, the increment in COX-2 expression induced by Ibuprofen, and was able to maintain PGE2 levels similar to the control group after 14 days.	Arginine	28-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-89
15736048-6	2005	In contrast, treatment with L-Arg reduced the delay of the lesion, the increment in COX-2 expression induced by Ibuprofen, and was able to maintain PGE2 levels similar to the control group after 14 days.	Ibuprofen	112-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-89
15778400-2	2005	COX-2 is the inducible isoform that is up-regulated by proinflammatory agents, initiating many prostanoid-mediated pathological aspects of inflammation.	Prostaglandins	95-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
15778400-4	2005	In this study we demonstrate that COX-2 is induced by RSV infection of human lung alveolar epithelial cells with the concomitant production of PGs.	Phosphatidylglycerols	143-146	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-39
15778400-6	2005	PG production was inhibited preferentially by NS-398, a COX-2-specific inhibitor, and indomethacin, a pan-COX inhibitor, but not by SC-560, a COX-1-specific inhibitor.	Prostaglandins	0-2	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-61
15778400-6	2005	PG production was inhibited preferentially by NS-398, a COX-2-specific inhibitor, and indomethacin, a pan-COX inhibitor, but not by SC-560, a COX-1-specific inhibitor.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	46-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-61
15881602-0	2005	Quantitative structure activity relationship studies of diaryl thiophen derivatives as selective COX-2 inhibitors.	diaryl thiophen	56-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
15881602-1	2005	QSAR studies were carried out on a series of diaryl thiophens that act as selective COX-2 inhibitors using Molecular Operating Environment (MOE).	diaryl thiophens	45-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-89
15741106-0	2005	Structural, spectroscopic and thermal characterization of 2-tert-butylaminomethylpyridine-6-carboxylic acid methylester and its Fe(III), Co(II), Ni(II), Cu(II), Zn(II) and UO(2)(II) complexes.	2-tert-butylaminomethylpyridine-6-carboxylic acid	58-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-143
15741106-1	2005	Fe(III), Co(II), Ni(II), Cu(II), Zn(II) and UO(2)(II) complexes with the ligand 2-tert-butylaminomethylpyridine-6-carboxylic acid methylester (HL(2)) have been prepared and characterized by elemental analyses, molar conductance, magnetic moment, thermal analysis and spectral data.	2-tert-butylaminomethylpyridine-6-carboxylic acid	80-129	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	9-15
15841323-2	2005	The formation of PGI(2) in response to proinflammatory cytokines is catalysed by the inducible cyclooxygenase (COX) isoform COX-2.	Epoprostenol	17-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	124-129
15841323-6	2005	We found that rhAPC, at supra-therapeutical concentrations (500 ng/ml-20 microg/ml), upregulated the amount of COX-2-mRNA in HUVEC at t=3-9 h and caused a time- and dose-dependent release of 6-keto PGF(1 alpha), the stable hydrolysis product of prostacyclin.	6-keto pgf	191-201	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	111-116
15841323-6	2005	We found that rhAPC, at supra-therapeutical concentrations (500 ng/ml-20 microg/ml), upregulated the amount of COX-2-mRNA in HUVEC at t=3-9 h and caused a time- and dose-dependent release of 6-keto PGF(1 alpha), the stable hydrolysis product of prostacyclin.	Epoprostenol	245-257	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	111-116
15841323-12	2005	These results demonstrate that induction of COX-2-expression is an important response of HUVEC to stimulation with rhAPC and may represent a new molecular mechanism, by which rhAPC promotes upregulation of prostanoid production in human endothelium.	Prostaglandins	206-216	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-49
15783223-7	2005	On the basis of these spectroscopic and theoretical analyses, 1 is best described as containing an intermediate spin FeII ion, whereas for the corresponding cobalt complex, oxidation states describing a d6 (CoIII) or d7 (CoII) electron configuration cannot be unambiguously assigned.	Cobalt	157-163	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	207-211
15779928-2	2005	This study demonstrates that addition of CoCl2 to PVCL in its globular conformation yields unimolecular core-shell polymer particles with the core decorated with Co(II) ions.	cobaltous chloride	41-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	162-168
15779928-2	2005	This study demonstrates that addition of CoCl2 to PVCL in its globular conformation yields unimolecular core-shell polymer particles with the core decorated with Co(II) ions.	poly-N-vinylcaprolactam	50-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	162-168
15657055-0	2005	A five-coordinate metal center in Co(II)-substituted VanX.	Metals	18-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-40
15657055-0	2005	A five-coordinate metal center in Co(II)-substituted VanX.	vanx	53-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-40
15657055-5	2005	Single scattering fits of EXAFS data indicate that the metal ions in both native Zn(II)-containing and Co(II)-substituted VanX have the same coordination number and that the metal ions are coordinated by 5 nitrogen/oxygen ligands at approximately 2.0 angstroms.	Metals	55-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-109
15657055-5	2005	Single scattering fits of EXAFS data indicate that the metal ions in both native Zn(II)-containing and Co(II)-substituted VanX have the same coordination number and that the metal ions are coordinated by 5 nitrogen/oxygen ligands at approximately 2.0 angstroms.	vanx	122-126	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-109
15657055-5	2005	Single scattering fits of EXAFS data indicate that the metal ions in both native Zn(II)-containing and Co(II)-substituted VanX have the same coordination number and that the metal ions are coordinated by 5 nitrogen/oxygen ligands at approximately 2.0 angstroms.	Metals	174-179	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-109
15657055-5	2005	Single scattering fits of EXAFS data indicate that the metal ions in both native Zn(II)-containing and Co(II)-substituted VanX have the same coordination number and that the metal ions are coordinated by 5 nitrogen/oxygen ligands at approximately 2.0 angstroms.	Nitrogen	206-214	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-109
15657055-5	2005	Single scattering fits of EXAFS data indicate that the metal ions in both native Zn(II)-containing and Co(II)-substituted VanX have the same coordination number and that the metal ions are coordinated by 5 nitrogen/oxygen ligands at approximately 2.0 angstroms.	Oxygen	215-221	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-109
15657055-6	2005	These data demonstrate that Co(II) (and Zn(II) from EXAFS studies) is five-coordinate in VanX in contrast to previous crystallographic studies (Bussiere, D. E., Pratt, S. D., Katz, L., Severin, J. M., Holzman, T., and Park, C. H. (1998) Mol.	vanx	89-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-34
15657055-8	2005	These spectroscopic studies also demonstrate that the metal ion in Co(II)-substituted VanX when complexed with a phosphinate analog of substrate D-Ala-D-Ala is also five-coordinate.	Metals	54-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-73
15657055-8	2005	These spectroscopic studies also demonstrate that the metal ion in Co(II)-substituted VanX when complexed with a phosphinate analog of substrate D-Ala-D-Ala is also five-coordinate.	vanx	86-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-73
15657055-8	2005	These spectroscopic studies also demonstrate that the metal ion in Co(II)-substituted VanX when complexed with a phosphinate analog of substrate D-Ala-D-Ala is also five-coordinate.	phosphinate	113-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-73
15657055-8	2005	These spectroscopic studies also demonstrate that the metal ion in Co(II)-substituted VanX when complexed with a phosphinate analog of substrate D-Ala-D-Ala is also five-coordinate.	alanylalanine	145-156	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-73
15902876-6	2005	CONCLUSION: This observation, which constitutes, as far as we know, the first case report of hemorrhagic ulcerated colitis related to celecoxib, confirms the colic toxicity of anti-Cox2 and identify a new cause of acute colitis.	Celecoxib	134-143	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	181-185
15739013-4	2005	A synergistic effect of Cu(II) with a second metal ion (Ni(II), Co(II) or Mn(II) traces) was observed.	cu(ii)	24-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-70
15739015-0	2005	Kinetics and mechanism of the Co(II)-assisted oxidation of thioureas by dioxygen.	Thiourea	59-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-35
15739015-0	2005	Kinetics and mechanism of the Co(II)-assisted oxidation of thioureas by dioxygen.	Oxygen	72-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-35
15756315-0	2005	A chiral layered Co(II) coordination polymer with helical chains from achiral materials.	Polymers	37-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22
15928593-4	2005	Cyclooxygenases, COX-1 and COX-2, are crucial in the metabolic pathway leading to the generation of prostanoids.	Prostaglandins	100-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-32
15713945-0	2005	Complications of the COX-2 inhibitors parecoxib and valdecoxib after cardiac surgery.	parecoxib	38-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-26
15713945-0	2005	Complications of the COX-2 inhibitors parecoxib and valdecoxib after cardiac surgery.	valdecoxib	52-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-26
15826877-5	2005	Additionally we studied the effects of the pretreatment with the non-selective anti-inflammatory drug indomethacin (n = 13) or the selective COX-2 inhibitor celecoxib (n = 12) and compared the effects to those of the pretreatment with vehicle (n = 11).	Celecoxib	157-166	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	141-146
16851538-1	2005	In the present work we studied, for the first time, the kinetics of adsorption of the Co(H(2)O)(6)(2+) species on the "electrolytic solution/gamma-Al(2)O(3)" interface at pH = 7 and 25 degrees C for a very broad range of Co(II) surface concentrations ranged from 0.03 to 6 theoretical Co(H(2)O)(6)(2+) surface layers.	co(h(2)o	86-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	221-227
16851538-1	2005	In the present work we studied, for the first time, the kinetics of adsorption of the Co(H(2)O)(6)(2+) species on the "electrolytic solution/gamma-Al(2)O(3)" interface at pH = 7 and 25 degrees C for a very broad range of Co(II) surface concentrations ranged from 0.03 to 6 theoretical Co(H(2)O)(6)(2+) surface layers.	co(h(2)o)	86-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	221-227
15727869-5	2005	The structure-activity relationships of these naphthols analyzed by docking experiments, indicated that the presence of hydroxyl group at C-1 position on the naphthalene nucleus enhanced the anti-inflammatory activity towards COX-2 via hydrogen bonding to the COX-2 Val 523 side chain.	Naphthols	46-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	226-231
15727869-5	2005	The structure-activity relationships of these naphthols analyzed by docking experiments, indicated that the presence of hydroxyl group at C-1 position on the naphthalene nucleus enhanced the anti-inflammatory activity towards COX-2 via hydrogen bonding to the COX-2 Val 523 side chain.	Naphthols	46-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	260-265
15727869-5	2005	The structure-activity relationships of these naphthols analyzed by docking experiments, indicated that the presence of hydroxyl group at C-1 position on the naphthalene nucleus enhanced the anti-inflammatory activity towards COX-2 via hydrogen bonding to the COX-2 Val 523 side chain.	naphthalene	158-169	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	226-231
15727869-5	2005	The structure-activity relationships of these naphthols analyzed by docking experiments, indicated that the presence of hydroxyl group at C-1 position on the naphthalene nucleus enhanced the anti-inflammatory activity towards COX-2 via hydrogen bonding to the COX-2 Val 523 side chain.	naphthalene	158-169	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	260-265
15727869-5	2005	The structure-activity relationships of these naphthols analyzed by docking experiments, indicated that the presence of hydroxyl group at C-1 position on the naphthalene nucleus enhanced the anti-inflammatory activity towards COX-2 via hydrogen bonding to the COX-2 Val 523 side chain.	Hydrogen	236-244	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	226-231
15727869-5	2005	The structure-activity relationships of these naphthols analyzed by docking experiments, indicated that the presence of hydroxyl group at C-1 position on the naphthalene nucleus enhanced the anti-inflammatory activity towards COX-2 via hydrogen bonding to the COX-2 Val 523 side chain.	Hydrogen	236-244	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	260-265
15727869-5	2005	The structure-activity relationships of these naphthols analyzed by docking experiments, indicated that the presence of hydroxyl group at C-1 position on the naphthalene nucleus enhanced the anti-inflammatory activity towards COX-2 via hydrogen bonding to the COX-2 Val 523 side chain.	Valine	266-269	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	226-231
15727869-5	2005	The structure-activity relationships of these naphthols analyzed by docking experiments, indicated that the presence of hydroxyl group at C-1 position on the naphthalene nucleus enhanced the anti-inflammatory activity towards COX-2 via hydrogen bonding to the COX-2 Val 523 side chain.	Valine	266-269	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	260-265
15727869-9	2005	The results provide a model for the binding of the naphthol derivatives to COX-2 and facilitate the design of more potent or selective analogs prior to synthesis.	Naphthols	51-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
15788676-4	2005	Although high levels of cPLA(2) and COX-2 expression are predicted to facilitate maximal prostaglandin production, tumors frequently displayed a high-COX-2/low-cPLA(2) phenotype.	Prostaglandins	89-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-41
15788676-10	2005	Our data further support the model in which colon cancer growth is favored when intracellular arachidonic acid levels are suppressed by inhibition of cPLA(2) or by a high-COX-2/low-cPLA(2) phenotype.	Arachidonic Acid	94-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	171-176
15674245-5	2005	Two metal centres, modelled as mononuclear copper and dinuclear copper, are located in soluble regions of each pmoB subunit, which resembles cytochrome c oxidase subunit II.	Metals	4-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	141-172
15674245-5	2005	Two metal centres, modelled as mononuclear copper and dinuclear copper, are located in soluble regions of each pmoB subunit, which resembles cytochrome c oxidase subunit II.	Copper	43-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	141-172
15674245-5	2005	Two metal centres, modelled as mononuclear copper and dinuclear copper, are located in soluble regions of each pmoB subunit, which resembles cytochrome c oxidase subunit II.	Copper	64-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	141-172
15921208-2	2005	We hypothesize that Cox-2 also might be relevant in the etiology of nasal polyps of aspirin-tolerant patients by their effects on inflammatory mediators as well as on microvascular permeability.	Aspirin	84-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-25
15698789-3	2005	Structure-activity relationship studies on these compounds revealed that only sulfides with (Z)-configuration have potential COX-2 inhibitory activity.	Sulfides	78-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-130
15767780-0	2005	COX-2 inhibitor, NS398, enhances Fas-mediated apoptosis via modulation of the PTEN-Akt pathway in human gastric carcinoma cell lines.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	17-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
15767780-0	2005	COX-2 inhibitor, NS398, enhances Fas-mediated apoptosis via modulation of the PTEN-Akt pathway in human gastric carcinoma cell lines.	ammonium ferrous sulfate	33-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
15767780-4	2005	This study examined whether NS398, a COX-2 inhibitor, inhibited cell proliferation and increased Fas-mediated apoptosis in human gastric carcinoma cell lines.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	28-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-42
15767780-5	2005	Treatment of NS398 inhibited cell proliferation in MKN-45, which expressed the highest level of COX-2 among seven human gastric carcinoma cell lines, in a dose- and time-dependent manner, in contrast to less prominent effects in KATO-III, which expresses no COX-2.	mkn-45	51-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-101
15767780-5	2005	Treatment of NS398 inhibited cell proliferation in MKN-45, which expressed the highest level of COX-2 among seven human gastric carcinoma cell lines, in a dose- and time-dependent manner, in contrast to less prominent effects in KATO-III, which expresses no COX-2.	mkn-45	51-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	258-263
15767780-9	2005	These findings suggest that COX-2 might inhibit Fas-mediated apoptosis in human gastric carcinoma cell lines, especially MKN-45, by modulating PTEN and Akt.	ammonium ferrous sulfate	48-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
15767780-9	2005	These findings suggest that COX-2 might inhibit Fas-mediated apoptosis in human gastric carcinoma cell lines, especially MKN-45, by modulating PTEN and Akt.	mkn-45	121-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
15564329-5	2005	The effects of LPS on cortisol were attenuated in the presence of both indomethacin and a specific COX-2 inhibitor, but not a COX-1 inhibitor, suggesting an obligatory role for COX-2 activation and prostaglandin synthesis in the adrenal response to LPS.	Hydrocortisone	22-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-104
15564329-5	2005	The effects of LPS on cortisol were attenuated in the presence of both indomethacin and a specific COX-2 inhibitor, but not a COX-1 inhibitor, suggesting an obligatory role for COX-2 activation and prostaglandin synthesis in the adrenal response to LPS.	Hydrocortisone	22-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	177-182
15564329-5	2005	The effects of LPS on cortisol were attenuated in the presence of both indomethacin and a specific COX-2 inhibitor, but not a COX-1 inhibitor, suggesting an obligatory role for COX-2 activation and prostaglandin synthesis in the adrenal response to LPS.	Indomethacin	71-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	177-182
15589231-6	2005	The detection limits of these metal ions were 0.03, 0.4, 0.04, 0.1, 0.15, 0.05, 0.2, and 3.2 microg/kg for Cd(II), Pb(II), Cu(II), Zn(II), Co(II), Ni(II), Cr(VI), and Mo(VI), respectively, with very good accuracy (standard deviation is below 2%).	Metals	30-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-145
15640281-4	2005	Here we show that engagement of CD44 with signaling monoclonal antibodies (mAbs) or its natural ligand hyaluronic acid induces COX-2 and prostacyclin (PGI2) formation in human EC.	Hyaluronic Acid	103-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	127-132
15720401-9	2005	These studies suggest that cPLA2-alpha and COX-2 may function together at a distinct and novel compartment for eicosanoid signalling.	Eicosanoids	111-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
15723448-4	2005	This investigation consists of a double-blind, randomized, placebo-controlled trial aimed at comparing the effects of the selective COX-2 inhibitor celecoxib (200 mg every 12 hours for a total of 5 doses) on platelet and renal function and the renal response to furosemide (40 mg intravenously) with those of naproxen (500 mg every 12 hours for a total of 5 doses) and placebo in 28 patients with cirrhosis and ascites.	Celecoxib	148-157	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-137
15843042-2	2005	In the present study, we found that 12-o-tetradecanoylphorbol 13-acetate (TPA) induced cyclooxygenase 2 (COX-2), but not COX-1, protein expression in HL-60 cells, and the addition of arachidonic acid (AA) in the presence or absence of TPA significantly reduced the viability of HL-60 cells, an effect that was blocked by adding the COX inhibitors, NS398 and aspirin.	Tetradecanoylphorbol Acetate	74-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-110
15871445-3	2005	In this study, we evaluated the tolerability of celecoxib, a selective COX-2 inhibitor, in patients with analgesic intolerance.	Celecoxib	48-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-76
15702232-5	2005	COX-2 expression was detected in the cytoplasm of non-cancerous epithelium in 9 cases in the HBA group and 5 cases in the LBA group.	hba	93-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
15702232-5	2005	COX-2 expression was detected in the cytoplasm of non-cancerous epithelium in 9 cases in the HBA group and 5 cases in the LBA group.	1,3-DIMETHOXY-2-PROPANOL	122-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
15702232-6	2005	The positive rate of COX-2 overexpression was significantly higher in the HBA group than in the LBA group (p&lt;0.05).	1,3-DIMETHOXY-2-PROPANOL	96-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-26
15926604-4	2005	COX-2 inhibitors may decrease vascular prostacyclin production and may tip the balance in favour of prothrombotic eicosanoids (thromboxane A2) and lead to increased cardiovascular thrombotic events.	Epoprostenol	39-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
15926604-4	2005	COX-2 inhibitors may decrease vascular prostacyclin production and may tip the balance in favour of prothrombotic eicosanoids (thromboxane A2) and lead to increased cardiovascular thrombotic events.	Eicosanoids	114-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
15926604-5	2005	COX-2 inhibitors can also result into increase blood pressure, macular eruptions, urticaria, pseudoporphyria, erythema multiforme, oedema, worsening of heart failure, fatal allergic vasculitis and aggravation of doxorubicin-mediated cardiac injury.	Doxorubicin	212-223	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
15741619-4	2005	Celecoxib, a COX-2 inhibitor, recently was approved for the treatment of acute pain.	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
15728468-1	2005	Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for the treatment of inflammatory diseases and target cyclooxygenases 1 and 2 (Cox-1, Cox-2) that are responsible for PG production.	pg	180-182	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	148-153
15572651-2	2005	A number of COX-2 inhibitors, including celecoxib and rofecoxib, are already used in man for the treatment of inflammatory pain.	Celecoxib	40-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-17
15494548-3	2005	We report here the pharmacological properties of a third selective COX-2 inhibitor, valdecoxib, which is the most potent and in vitro selective of the marketed COX-2 inhibitors that we have studied.	valdecoxib	84-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-72
15494548-3	2005	We report here the pharmacological properties of a third selective COX-2 inhibitor, valdecoxib, which is the most potent and in vitro selective of the marketed COX-2 inhibitors that we have studied.	valdecoxib	84-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	160-165
15494548-5	2005	Valdecoxib potently inhibits recombinant COX-2, with an IC(50) of 0.005 microM; this compares with IC values of 0.05 microM for celecoxib, 0.5 microM for rofecoxib, and 5 microM for etoricoxib.	valdecoxib	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-46
15494548-5	2005	Valdecoxib potently inhibits recombinant COX-2, with an IC(50) of 0.005 microM; this compares with IC values of 0.05 microM for celecoxib, 0.5 microM for rofecoxib, and 5 microM for etoricoxib.	Etoricoxib	182-192	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-46
15494548-6	2005	Unique binding interactions of valdecoxib with COX-2 translate into a fast rate of inactivation of COX-2 (110,000 M/s compared with 7000 M/s for rofecoxib and 80 M/s for etoricoxib).	valdecoxib	31-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
15494548-6	2005	Unique binding interactions of valdecoxib with COX-2 translate into a fast rate of inactivation of COX-2 (110,000 M/s compared with 7000 M/s for rofecoxib and 80 M/s for etoricoxib).	valdecoxib	31-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-104
15494548-6	2005	Unique binding interactions of valdecoxib with COX-2 translate into a fast rate of inactivation of COX-2 (110,000 M/s compared with 7000 M/s for rofecoxib and 80 M/s for etoricoxib).	rofecoxib	145-154	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
15572651-2	2005	A number of COX-2 inhibitors, including celecoxib and rofecoxib, are already used in man for the treatment of inflammatory pain.	rofecoxib	54-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-17
15494548-6	2005	Unique binding interactions of valdecoxib with COX-2 translate into a fast rate of inactivation of COX-2 (110,000 M/s compared with 7000 M/s for rofecoxib and 80 M/s for etoricoxib).	Etoricoxib	170-180	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
15742426-0	2005	Trial of tramadol/acetaminophen tablets for osteoarthritis pain in subjects receiving a COX-2 nonsteroidal antiinflammatory drug.	Tramadol	9-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-93
15494548-6	2005	Unique binding interactions of valdecoxib with COX-2 translate into a fast rate of inactivation of COX-2 (110,000 M/s compared with 7000 M/s for rofecoxib and 80 M/s for etoricoxib).	Etoricoxib	170-180	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-104
15494548-7	2005	The overall saturation binding affinity for COX-2 of valdecoxib is 2.6 nM (compared with 1.6 nM for celecoxib, 51 nM for rofecoxib, and 260 nM for etoricoxib), with a slow off-rate (t(1/2) approximately 98 min).	valdecoxib	53-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-49
15494548-7	2005	The overall saturation binding affinity for COX-2 of valdecoxib is 2.6 nM (compared with 1.6 nM for celecoxib, 51 nM for rofecoxib, and 260 nM for etoricoxib), with a slow off-rate (t(1/2) approximately 98 min).	Celecoxib	100-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-49
15494548-7	2005	The overall saturation binding affinity for COX-2 of valdecoxib is 2.6 nM (compared with 1.6 nM for celecoxib, 51 nM for rofecoxib, and 260 nM for etoricoxib), with a slow off-rate (t(1/2) approximately 98 min).	rofecoxib	121-130	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-49
15494548-7	2005	The overall saturation binding affinity for COX-2 of valdecoxib is 2.6 nM (compared with 1.6 nM for celecoxib, 51 nM for rofecoxib, and 260 nM for etoricoxib), with a slow off-rate (t(1/2) approximately 98 min).	Etoricoxib	147-157	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-49
15494548-9	2005	Collectively, these data provide a mechanistic basis for the potency and in vitro selectivity of valdecoxib for COX-2.	valdecoxib	97-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-117
15494548-10	2005	Valdecoxib showed similar activity in the human whole-blood COX assay (COX-2 IC(50) = 0.24 microM; COX-1 IC(50) = 21.9 microM).	valdecoxib	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-76
15683791-6	2005	The results from experimental data relating to the simultaneous spectrophotometric determination of Zn(II), Co(II) and Ni(II) based on their complexes with 1-(2-pyridylazo)2-naphthol in micellar media were presented as real model for resolution of the ternary systems.	1-(2-pyridylazo)-2-naphthol	156-182	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-114
15664436-12	2005	COX-2 enzyme activity was inhibited by 68% at a concentration of 5 mM o-cresol.	2-cresol	70-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
15696570-1	2005	OBJECTIVE: To evaluate the effects of cardiovascular comorbidities and aspirin coprescription on cyclooxygenase (COX)-2 inhibitor (coxib) prescribing patterns among rheumatologists.	Aspirin	71-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-119
15946562-0	2005	[Mechanism of apoptosis induced by specific COX-2 inhibitor SC236 in gastric cancer cells].	4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide	60-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-49
15946562-1	2005	OBJECTIVE: To investigate the underlying mechanism of apoptosis-inducing effect of a specific COX-2 inhibitor SC236 in gastric cancer cells.	4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide	110-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-99
18969902-2	2005	The method exploits the enhancement of cobalt peak current observed in the system Co(II)-nioxime-cetyltrimethylammonium bromide-piperazine-N,N"-bis(2-ethanesulfonic acid).	Cobalt	39-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-88
18969902-6	2005	The validation of the method is performed by the analyses of certified reference materials and comparing the result of Co(II) determination in river water sample by the proposed method with those obtained by ET AAS.	Water	149-154	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-125
21187016-1	2005	BACKGROUND: In recent years, many investigations have showed that COX-2 inhibitors not only inhibit the growth of tumor cells but also enhance the cytotoxicity of anticancer drugs, such as NS-398, a selective COX-2 inhibitor.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	189-195	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-71
21187016-1	2005	BACKGROUND: In recent years, many investigations have showed that COX-2 inhibitors not only inhibit the growth of tumor cells but also enhance the cytotoxicity of anticancer drugs, such as NS-398, a selective COX-2 inhibitor.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	189-195	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	209-214
15455372-0	2005	Green tea constituent epigallocatechin-3-gallate selectively inhibits COX-2 without affecting COX-1 expression in human prostate carcinoma cells.	epigallocatechin gallate	22-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-75
15455372-6	2005	Here, we show that EGCG inhibits COX-2 without affecting COX-1 expression at both the mRNA and protein levels, in androgen-sensitive LNCaP and androgen-insensitive PC-3 human prostate carcinoma cells.	epigallocatechin gallate	19-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-38
15550400-3	2005	Cyclooxygenase (COX)-2, an inducible enzyme that catalyzes the conversion of arachidonic acid to prostaglandins and other eicosanoids, is also induced by hypoxia.	Arachidonic Acid	77-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-22
15550400-3	2005	Cyclooxygenase (COX)-2, an inducible enzyme that catalyzes the conversion of arachidonic acid to prostaglandins and other eicosanoids, is also induced by hypoxia.	Prostaglandins	97-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-22
15550400-3	2005	Cyclooxygenase (COX)-2, an inducible enzyme that catalyzes the conversion of arachidonic acid to prostaglandins and other eicosanoids, is also induced by hypoxia.	Eicosanoids	122-133	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-22
15550400-13	2005	Finally, forced expression of COX-2 suppressed both basal and hypoxia-induced p53 transcriptional activity, and this effect was mimicked by the addition of PGE2 to wild-type cells.	Dinoprostone	156-160	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-35
15902994-0	2005	Selective COX-2 inhibition with different doses of rofecoxib does not impair endothelial function in patients with coronary artery disease.	rofecoxib	51-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
15681840-10	2005	These results show for the first time that aberrant COX-2 expression contributes to the development of fibrocystic changes (FC), indicating that COX-2 and COX-2-mediated PG synthesis represent potential targets for the therapy of this most frequent benign disorder of the human breast.	Prostaglandins	170-172	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-57
15458923-1	2005	We have previously shown that the cyclooxygenase (COX)-2/PGE2 pathway plays a key role in VEGF production in gastric fibroblasts.	Dinoprostone	57-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-56
15458923-8	2005	N-(2-cyclohexyloxy-4-nitrophenyl)-methanesulfonamide (NS-398), a selective COX-2 inhibitor, totally inhibited PGE2 production at both the 8-h and 24-h time points, suggesting that COX-2-dependent PGE2 generation does not depend on mPGES-1 activity at the early stage.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	0-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
15458923-8	2005	N-(2-cyclohexyloxy-4-nitrophenyl)-methanesulfonamide (NS-398), a selective COX-2 inhibitor, totally inhibited PGE2 production at both the 8-h and 24-h time points, suggesting that COX-2-dependent PGE2 generation does not depend on mPGES-1 activity at the early stage.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	0-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	180-185
15458923-8	2005	N-(2-cyclohexyloxy-4-nitrophenyl)-methanesulfonamide (NS-398), a selective COX-2 inhibitor, totally inhibited PGE2 production at both the 8-h and 24-h time points, suggesting that COX-2-dependent PGE2 generation does not depend on mPGES-1 activity at the early stage.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	54-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
15458923-8	2005	N-(2-cyclohexyloxy-4-nitrophenyl)-methanesulfonamide (NS-398), a selective COX-2 inhibitor, totally inhibited PGE2 production at both the 8-h and 24-h time points, suggesting that COX-2-dependent PGE2 generation does not depend on mPGES-1 activity at the early stage.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	54-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	180-185
15458923-8	2005	N-(2-cyclohexyloxy-4-nitrophenyl)-methanesulfonamide (NS-398), a selective COX-2 inhibitor, totally inhibited PGE2 production at both the 8-h and 24-h time points, suggesting that COX-2-dependent PGE2 generation does not depend on mPGES-1 activity at the early stage.	Dinoprostone	110-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
15458923-8	2005	N-(2-cyclohexyloxy-4-nitrophenyl)-methanesulfonamide (NS-398), a selective COX-2 inhibitor, totally inhibited PGE2 production at both the 8-h and 24-h time points, suggesting that COX-2-dependent PGE2 generation does not depend on mPGES-1 activity at the early stage.	Dinoprostone	110-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	180-185
15780952-9	2005	IL-1alpha activated ERK phosphorylation and PD98059 greatly inhibited both COX-2 mRNA expression and PGE(2) production induced by IL-1alpha in PDL cells.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	44-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
15641113-2	2005	In both complexes, the sp(3) nitrogen of quinuclidine is protonated, whereas the sp(2) nitrogen of quinoline is linked to the Co(II) atom, which coordinates three chlorine atoms in distorted tetrahedral geometry.	sp(2) nitrogen	81-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-132
15723653-9	2005	In addition, prostaglandin E2 almost completely reversed the effect of JTE-522, strongly suggesting the involvement of a COX-2-dependent pathway.	Dinoprostone	13-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-126
15641113-2	2005	In both complexes, the sp(3) nitrogen of quinuclidine is protonated, whereas the sp(2) nitrogen of quinoline is linked to the Co(II) atom, which coordinates three chlorine atoms in distorted tetrahedral geometry.	quinoline	99-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-132
15641113-2	2005	In both complexes, the sp(3) nitrogen of quinuclidine is protonated, whereas the sp(2) nitrogen of quinoline is linked to the Co(II) atom, which coordinates three chlorine atoms in distorted tetrahedral geometry.	Chlorine	163-171	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-132
15859361-4	2005	Celecoxib (CE) is a novel drug, with high selectivity and affinity for COX-2 enzyme.	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-76
15645120-5	2005	These results show that the differentiation-inducing agents, particularly SB, suppress growth of oral squamous carcinoma cells through apoptosis and induce cell differentiation possibly through mechanisms involving COX-2, p27Kip1 and/or p21WAF1/Cip1 in vitro and in vivo.	Butyric Acid	74-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	215-220
15645119-2	2005	To clarify the pathological significance of COX-2, we examined the effect of a selective COX-2 inhibitor, NS398, on two human gastric carcinoma cell lines, MKN-45 and KATO-III, and the expression of Skp2, P27/Kip1 and COX-2 protein in human gastric carcinomas.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	106-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-94
15652404-2	2005	Abeta(1-42) (5 microM) applied for 8 h induced the expression and increased the production of the pro-inflammatory cytokines IL-6, IL-1beta, TNF-alpha, the inducible enzyme COX-2 and chemokine IL-8.	UNII-042A8N37WH	0-5	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	173-178
15645119-2	2005	To clarify the pathological significance of COX-2, we examined the effect of a selective COX-2 inhibitor, NS398, on two human gastric carcinoma cell lines, MKN-45 and KATO-III, and the expression of Skp2, P27/Kip1 and COX-2 protein in human gastric carcinomas.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	106-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-94
15645119-4	2005	In MKN-45, NS398 induced up-regulation of P27/Kip1 and down-regulation of COX-2, cyclin D1 and Skp2.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	11-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
15645119-7	2005	Our results suggested that: a) NS398 induced inhibition of cell proliferation through cell cycle arrest and suppressed the expression of Skp2 in COX-2-expressing gastric carcinoma cells, and b) COX-2 contributes to the expression of Skp2 and poor survival in human gastric carcinomas.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	31-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-150
15645119-7	2005	Our results suggested that: a) NS398 induced inhibition of cell proliferation through cell cycle arrest and suppressed the expression of Skp2 in COX-2-expressing gastric carcinoma cells, and b) COX-2 contributes to the expression of Skp2 and poor survival in human gastric carcinomas.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	31-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	194-199
15645120-2	2005	Treatment of SCC25 oral squamous carcinoma cells with sodium butyrate (SB) at 0.5-5 mM or all-trans retinoic acid (ATRA) at 3-300 microM inhibited cell growth and induced apoptosis in a dose-dependent manner with concomittant increases in expression of keratin 13, p21WAF1/Cip1 and p27Kip1 and decreases in expression of COX-2.	Butyric Acid	54-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	321-326
15645120-2	2005	Treatment of SCC25 oral squamous carcinoma cells with sodium butyrate (SB) at 0.5-5 mM or all-trans retinoic acid (ATRA) at 3-300 microM inhibited cell growth and induced apoptosis in a dose-dependent manner with concomittant increases in expression of keratin 13, p21WAF1/Cip1 and p27Kip1 and decreases in expression of COX-2.	Butyric Acid	71-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	321-326
15645120-2	2005	Treatment of SCC25 oral squamous carcinoma cells with sodium butyrate (SB) at 0.5-5 mM or all-trans retinoic acid (ATRA) at 3-300 microM inhibited cell growth and induced apoptosis in a dose-dependent manner with concomittant increases in expression of keratin 13, p21WAF1/Cip1 and p27Kip1 and decreases in expression of COX-2.	Tretinoin	115-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	321-326
15659218-3	2005	The neurotoxic effect of COX-2 is believed to occur through downstream effects of its prostaglandin products.	Prostaglandins	86-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-30
15626588-5	2005	Functionally, these data translate into a differential constrictor response of the ductus to dual, COX1/COX2, vs. COX2-specific inhibitors (indomethacin vs. L-745,337), with the latter being less effective specifically prior to term.	Indomethacin	140-152	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-118
15626588-7	2005	Furthermore, when studied separately, COX1 and COX2 prove to be unevenly responsive to indomethacin, and an immediate and fast developing contraction of the vessel occurs only when COX2 is inhibited.	Indomethacin	87-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-51
15791193-0	2005	[Prevention of heterotopic ossifications in hip arthroplasty: effectiveness of selective Cox-2 inhibitors (celecoxib) versus ketoprofen].	Celecoxib	107-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-94
15604423-11	2005	Moreover, the Cox-2 -765C variant displayed a slightly higher reduction in 11-dTxB2 level on treatment with aspirin.	11-dehydro-thromboxane B2	75-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
15604423-11	2005	Moreover, the Cox-2 -765C variant displayed a slightly higher reduction in 11-dTxB2 level on treatment with aspirin.	Aspirin	108-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
15680249-3	2005	We show that, in cytokine-treated synoviocytes (from non-rheumatic patients), NO-naproxen and NO-flurbiprofen like their parent compounds concentration-dependently reduce the levels of PGE2 (an index of COX-2 activity), with a corresponding rise in the release of GM-CSF.	naproxen-n-butyl nitrate	78-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	203-208
15680249-3	2005	We show that, in cytokine-treated synoviocytes (from non-rheumatic patients), NO-naproxen and NO-flurbiprofen like their parent compounds concentration-dependently reduce the levels of PGE2 (an index of COX-2 activity), with a corresponding rise in the release of GM-CSF.	Flurbiprofen	97-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	203-208
15680249-3	2005	We show that, in cytokine-treated synoviocytes (from non-rheumatic patients), NO-naproxen and NO-flurbiprofen like their parent compounds concentration-dependently reduce the levels of PGE2 (an index of COX-2 activity), with a corresponding rise in the release of GM-CSF.	Dinoprostone	185-189	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	203-208
15651893-3	2005	In an alternative synthesis from Co(II), dmpdacn, and air, the same C-bonded complex is obtained along with a novel hydroxylated Co(III) complex [Co(dmpdacnOH-O)Cl](2+) which has been similarly characterized.	co(dmpdacnoh-o)cl	146-163	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-39
15654764-2	2005	When using nitrocefin as the substrate, time-dependent absorption spectra demonstrate that Co(II)-substituted L1 utilizes a reaction mechanism, similar to that of the native Zn(II) enzyme, in which a short-lived intermediate forms.	nitrocefin	11-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-96
15654764-2	2005	When using nitrocefin as the substrate, time-dependent absorption spectra demonstrate that Co(II)-substituted L1 utilizes a reaction mechanism, similar to that of the native Zn(II) enzyme, in which a short-lived intermediate forms.	Zinc	174-180	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-96
15654764-3	2005	RFQ-EPR spectra of this intermediate demonstrate that the binding of substrate results in a change in the electronic properties of one or both of the Co(II)"s in the enzyme that is consistent with a change in the coordination sphere of this metal ion.	Metals	241-246	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	150-155
15668365-0	2005	Risk of upper gastrointestinal hemorrhage in warfarin users treated with nonselective NSAIDs or COX-2 inhibitors.	Warfarin	45-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-101
15668365-10	2005	CONCLUSIONS: Patients taking warfarin concomitantly with selective COX-2 inhibitors have an increased risk of hospitalization for upper GI hemorrhage.	Warfarin	29-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-72
15593132-10	2005	The complex formed with CoII presents the characteristic features for tetrahedral tetrathiolate coordination in its UV-visible spectrum.	tetrathiolate	82-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-28
15593132-11	2005	The sequence of APP170-188 contains only three cysteine residues, which is incompatible with a monomeric CoII-APP170-188 complex.	Cysteine	47-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-109
15593132-12	2005	EPR measurements of the complex with one equivalent of CoII show almost no signal at 4 K, which is compatible with an antiferromagnetic spin-coupling of the metal ions in a cluster structure.	Metals	157-162	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-59
15651788-1	2005	The regioselectivity of the metal-catalyzed ring opening of unsymmetrical 1,2-dioxines to cis-gamma-hydroxyenones was investigated using two different Co(II) salen complexes.	Metals	28-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-157
15651788-1	2005	The regioselectivity of the metal-catalyzed ring opening of unsymmetrical 1,2-dioxines to cis-gamma-hydroxyenones was investigated using two different Co(II) salen complexes.	1,2-dioxines	74-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-157
15651788-1	2005	The regioselectivity of the metal-catalyzed ring opening of unsymmetrical 1,2-dioxines to cis-gamma-hydroxyenones was investigated using two different Co(II) salen complexes.	cis-gamma-hydroxyenones	90-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-157
15455390-0	2005	Increased endothelial uptake of paclitaxel as a potential mechanism for its antiangiogenic effects: potentiation by Cox-2 inhibition.	Paclitaxel	32-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-121
15455390-4	2005	Exposing human umbilical vein ECs to low nanomolar (1-50 nM) concentrations of paclitaxel enhanced Cox-2 expression more than 2-fold, as measured by ELISA.	Paclitaxel	79-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-104
15455390-5	2005	Combined treatment with paclitaxel and the Cox-2 inhibitor NS-398 resulted in increased antiendothelial effects as compared to each agent alone.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	59-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
15558802-1	2005	BACKGROUND: In the current study, the authors report a Phase II trial of irinotecan (CPT-11), a topoisomerase I inhibitor active against malignant glioma (MG), with celecoxib, a selective COX-2 inhibitor, among MG patients with recurrent disease.	Irinotecan	73-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	188-193
15607906-7	2005	COX-2 expression in PBMCs was positively correlated with concentrations of total serum cholesterol, oxLDL, glutamate, or cystine.	Cholesterol	87-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
15607906-7	2005	COX-2 expression in PBMCs was positively correlated with concentrations of total serum cholesterol, oxLDL, glutamate, or cystine.	Glutamic Acid	107-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
15607906-7	2005	COX-2 expression in PBMCs was positively correlated with concentrations of total serum cholesterol, oxLDL, glutamate, or cystine.	Cystine	121-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
15627369-1	2005	By utilizing the novel metalloligand l(Cu), [Cu(2,4-pydca)(2)](2)(-) (2,4-pydca(2)(-) = pyridine-2,4-dicarboxylate), which possesses two kinds of coordination groups, selective bond formation with the series of the first-period transition metal ions (Mn(ii), Fe(ii), Co(ii), Cu(ii), and Zn(ii)) has been accomplished.	Copper	39-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	254-256
15627369-1	2005	By utilizing the novel metalloligand l(Cu), [Cu(2,4-pydca)(2)](2)(-) (2,4-pydca(2)(-) = pyridine-2,4-dicarboxylate), which possesses two kinds of coordination groups, selective bond formation with the series of the first-period transition metal ions (Mn(ii), Fe(ii), Co(ii), Cu(ii), and Zn(ii)) has been accomplished.	Copper	39-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	262-264
15627369-1	2005	By utilizing the novel metalloligand l(Cu), [Cu(2,4-pydca)(2)](2)(-) (2,4-pydca(2)(-) = pyridine-2,4-dicarboxylate), which possesses two kinds of coordination groups, selective bond formation with the series of the first-period transition metal ions (Mn(ii), Fe(ii), Co(ii), Cu(ii), and Zn(ii)) has been accomplished.	2,4-dicarboxylate	97-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	262-264
15627369-1	2005	By utilizing the novel metalloligand l(Cu), [Cu(2,4-pydca)(2)](2)(-) (2,4-pydca(2)(-) = pyridine-2,4-dicarboxylate), which possesses two kinds of coordination groups, selective bond formation with the series of the first-period transition metal ions (Mn(ii), Fe(ii), Co(ii), Cu(ii), and Zn(ii)) has been accomplished.	Copper	39-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	267-273
15627369-1	2005	By utilizing the novel metalloligand l(Cu), [Cu(2,4-pydca)(2)](2)(-) (2,4-pydca(2)(-) = pyridine-2,4-dicarboxylate), which possesses two kinds of coordination groups, selective bond formation with the series of the first-period transition metal ions (Mn(ii), Fe(ii), Co(ii), Cu(ii), and Zn(ii)) has been accomplished.	Metals	23-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	254-256
15627369-1	2005	By utilizing the novel metalloligand l(Cu), [Cu(2,4-pydca)(2)](2)(-) (2,4-pydca(2)(-) = pyridine-2,4-dicarboxylate), which possesses two kinds of coordination groups, selective bond formation with the series of the first-period transition metal ions (Mn(ii), Fe(ii), Co(ii), Cu(ii), and Zn(ii)) has been accomplished.	Copper	39-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	262-264
15627369-1	2005	By utilizing the novel metalloligand l(Cu), [Cu(2,4-pydca)(2)](2)(-) (2,4-pydca(2)(-) = pyridine-2,4-dicarboxylate), which possesses two kinds of coordination groups, selective bond formation with the series of the first-period transition metal ions (Mn(ii), Fe(ii), Co(ii), Cu(ii), and Zn(ii)) has been accomplished.	Metals	23-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	262-264
15627369-1	2005	By utilizing the novel metalloligand l(Cu), [Cu(2,4-pydca)(2)](2)(-) (2,4-pydca(2)(-) = pyridine-2,4-dicarboxylate), which possesses two kinds of coordination groups, selective bond formation with the series of the first-period transition metal ions (Mn(ii), Fe(ii), Co(ii), Cu(ii), and Zn(ii)) has been accomplished.	Metals	23-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	267-273
15627369-1	2005	By utilizing the novel metalloligand l(Cu), [Cu(2,4-pydca)(2)](2)(-) (2,4-pydca(2)(-) = pyridine-2,4-dicarboxylate), which possesses two kinds of coordination groups, selective bond formation with the series of the first-period transition metal ions (Mn(ii), Fe(ii), Co(ii), Cu(ii), and Zn(ii)) has been accomplished.	Copper	39-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	262-264
15627369-1	2005	By utilizing the novel metalloligand l(Cu), [Cu(2,4-pydca)(2)](2)(-) (2,4-pydca(2)(-) = pyridine-2,4-dicarboxylate), which possesses two kinds of coordination groups, selective bond formation with the series of the first-period transition metal ions (Mn(ii), Fe(ii), Co(ii), Cu(ii), and Zn(ii)) has been accomplished.	Metals	23-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	262-264
15627369-1	2005	By utilizing the novel metalloligand l(Cu), [Cu(2,4-pydca)(2)](2)(-) (2,4-pydca(2)(-) = pyridine-2,4-dicarboxylate), which possesses two kinds of coordination groups, selective bond formation with the series of the first-period transition metal ions (Mn(ii), Fe(ii), Co(ii), Cu(ii), and Zn(ii)) has been accomplished.	Metals	23-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	262-264
15627369-1	2005	By utilizing the novel metalloligand l(Cu), [Cu(2,4-pydca)(2)](2)(-) (2,4-pydca(2)(-) = pyridine-2,4-dicarboxylate), which possesses two kinds of coordination groups, selective bond formation with the series of the first-period transition metal ions (Mn(ii), Fe(ii), Co(ii), Cu(ii), and Zn(ii)) has been accomplished.	cu(2,4-pydca)(2)	45-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	254-256
15627369-3	2005	the use of a terminal ligand of 2,2"-bipyridine (2,2"-bpy), in addition to the cu(ii) ion, gives a zigzag 1-d assembly with the similar repeating unit as 4-6: {[Cu(2,2"-bpy)L(Cu)].3H(2)O}(N)() (9).	2,2'-Dipyridyl	32-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-84
15627369-3	2005	the use of a terminal ligand of 2,2"-bipyridine (2,2"-bpy), in addition to the cu(ii) ion, gives a zigzag 1-d assembly with the similar repeating unit as 4-6: {[Cu(2,2"-bpy)L(Cu)].3H(2)O}(N)() (9).	2,2'-Dipyridyl	49-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-84
15627369-1	2005	By utilizing the novel metalloligand l(Cu), [Cu(2,4-pydca)(2)](2)(-) (2,4-pydca(2)(-) = pyridine-2,4-dicarboxylate), which possesses two kinds of coordination groups, selective bond formation with the series of the first-period transition metal ions (Mn(ii), Fe(ii), Co(ii), Cu(ii), and Zn(ii)) has been accomplished.	cu(2,4-pydca)(2)	45-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	262-264
15627369-3	2005	the use of a terminal ligand of 2,2"-bipyridine (2,2"-bpy), in addition to the cu(ii) ion, gives a zigzag 1-d assembly with the similar repeating unit as 4-6: {[Cu(2,2"-bpy)L(Cu)].3H(2)O}(N)() (9).	2,2'-Dipyridyl	54-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-84
15627369-1	2005	By utilizing the novel metalloligand l(Cu), [Cu(2,4-pydca)(2)](2)(-) (2,4-pydca(2)(-) = pyridine-2,4-dicarboxylate), which possesses two kinds of coordination groups, selective bond formation with the series of the first-period transition metal ions (Mn(ii), Fe(ii), Co(ii), Cu(ii), and Zn(ii)) has been accomplished.	cu(2,4-pydca)(2)	45-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	267-273
15627369-3	2005	the use of a terminal ligand of 2,2"-bipyridine (2,2"-bpy), in addition to the cu(ii) ion, gives a zigzag 1-d assembly with the similar repeating unit as 4-6: {[Cu(2,2"-bpy)L(Cu)].3H(2)O}(N)() (9).	Tritium	180-182	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-84
15627369-4	2005	on the other hand, for Mn(ii) and Fe(ii) ions, L(Cu) shows a 2-carboxylate bridging mode to form an another 1-d assembly with a repeating motif of [-M-O-C-O-CU-O-C-O-]: [ML(Cu)(H(2)O)(4)](N)() (M = Mn (7), Fe (8)).	Copper	49-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-28
15627369-1	2005	By utilizing the novel metalloligand l(Cu), [Cu(2,4-pydca)(2)](2)(-) (2,4-pydca(2)(-) = pyridine-2,4-dicarboxylate), which possesses two kinds of coordination groups, selective bond formation with the series of the first-period transition metal ions (Mn(ii), Fe(ii), Co(ii), Cu(ii), and Zn(ii)) has been accomplished.	cu(2,4-pydca)(2)	45-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	262-264
15627369-4	2005	on the other hand, for Mn(ii) and Fe(ii) ions, L(Cu) shows a 2-carboxylate bridging mode to form an another 1-d assembly with a repeating motif of [-M-O-C-O-CU-O-C-O-]: [ML(Cu)(H(2)O)(4)](N)() (M = Mn (7), Fe (8)).	Copper	49-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-39
15627369-1	2005	By utilizing the novel metalloligand l(Cu), [Cu(2,4-pydca)(2)](2)(-) (2,4-pydca(2)(-) = pyridine-2,4-dicarboxylate), which possesses two kinds of coordination groups, selective bond formation with the series of the first-period transition metal ions (Mn(ii), Fe(ii), Co(ii), Cu(ii), and Zn(ii)) has been accomplished.	cu(2,4-pydca)(2)	45-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	262-264
15627369-4	2005	on the other hand, for Mn(ii) and Fe(ii) ions, L(Cu) shows a 2-carboxylate bridging mode to form an another 1-d assembly with a repeating motif of [-M-O-C-O-CU-O-C-O-]: [ML(Cu)(H(2)O)(4)](N)() (M = Mn (7), Fe (8)).	2-carboxylate	61-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-28
15627369-4	2005	on the other hand, for Mn(ii) and Fe(ii) ions, L(Cu) shows a 2-carboxylate bridging mode to form an another 1-d assembly with a repeating motif of [-M-O-C-O-CU-O-C-O-]: [ML(Cu)(H(2)O)(4)](N)() (M = Mn (7), Fe (8)).	2-carboxylate	61-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-39
15627369-1	2005	By utilizing the novel metalloligand l(Cu), [Cu(2,4-pydca)(2)](2)(-) (2,4-pydca(2)(-) = pyridine-2,4-dicarboxylate), which possesses two kinds of coordination groups, selective bond formation with the series of the first-period transition metal ions (Mn(ii), Fe(ii), Co(ii), Cu(ii), and Zn(ii)) has been accomplished.	2,4-pydca	48-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	254-256
15627369-1	2005	By utilizing the novel metalloligand l(Cu), [Cu(2,4-pydca)(2)](2)(-) (2,4-pydca(2)(-) = pyridine-2,4-dicarboxylate), which possesses two kinds of coordination groups, selective bond formation with the series of the first-period transition metal ions (Mn(ii), Fe(ii), Co(ii), Cu(ii), and Zn(ii)) has been accomplished.	2,4-pydca	48-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	262-264
15627369-1	2005	By utilizing the novel metalloligand l(Cu), [Cu(2,4-pydca)(2)](2)(-) (2,4-pydca(2)(-) = pyridine-2,4-dicarboxylate), which possesses two kinds of coordination groups, selective bond formation with the series of the first-period transition metal ions (Mn(ii), Fe(ii), Co(ii), Cu(ii), and Zn(ii)) has been accomplished.	2,4-pydca	48-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	267-273
15627369-1	2005	By utilizing the novel metalloligand l(Cu), [Cu(2,4-pydca)(2)](2)(-) (2,4-pydca(2)(-) = pyridine-2,4-dicarboxylate), which possesses two kinds of coordination groups, selective bond formation with the series of the first-period transition metal ions (Mn(ii), Fe(ii), Co(ii), Cu(ii), and Zn(ii)) has been accomplished.	2,4-pydca	48-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	262-264
15627369-4	2005	on the other hand, for Mn(ii) and Fe(ii) ions, L(Cu) shows a 2-carboxylate bridging mode to form an another 1-d assembly with a repeating motif of [-M-O-C-O-CU-O-C-O-]: [ML(Cu)(H(2)O)(4)](N)() (M = Mn (7), Fe (8)).	Carbon	49-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-28
15627369-1	2005	By utilizing the novel metalloligand l(Cu), [Cu(2,4-pydca)(2)](2)(-) (2,4-pydca(2)(-) = pyridine-2,4-dicarboxylate), which possesses two kinds of coordination groups, selective bond formation with the series of the first-period transition metal ions (Mn(ii), Fe(ii), Co(ii), Cu(ii), and Zn(ii)) has been accomplished.	2,4-pydca	48-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	262-264
15627369-4	2005	on the other hand, for Mn(ii) and Fe(ii) ions, L(Cu) shows a 2-carboxylate bridging mode to form an another 1-d assembly with a repeating motif of [-M-O-C-O-CU-O-C-O-]: [ML(Cu)(H(2)O)(4)](N)() (M = Mn (7), Fe (8)).	Carbon	49-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-39
15627369-4	2005	on the other hand, for Mn(ii) and Fe(ii) ions, L(Cu) shows a 2-carboxylate bridging mode to form an another 1-d assembly with a repeating motif of [-M-O-C-O-CU-O-C-O-]: [ML(Cu)(H(2)O)(4)](N)() (M = Mn (7), Fe (8)).	Copper	157-159	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-28
15627369-1	2005	By utilizing the novel metalloligand l(Cu), [Cu(2,4-pydca)(2)](2)(-) (2,4-pydca(2)(-) = pyridine-2,4-dicarboxylate), which possesses two kinds of coordination groups, selective bond formation with the series of the first-period transition metal ions (Mn(ii), Fe(ii), Co(ii), Cu(ii), and Zn(ii)) has been accomplished.	pyridine	88-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	254-256
15627369-4	2005	on the other hand, for Mn(ii) and Fe(ii) ions, L(Cu) shows a 2-carboxylate bridging mode to form an another 1-d assembly with a repeating motif of [-M-O-C-O-CU-O-C-O-]: [ML(Cu)(H(2)O)(4)](N)() (M = Mn (7), Fe (8)).	Copper	157-159	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-39
15627369-1	2005	By utilizing the novel metalloligand l(Cu), [Cu(2,4-pydca)(2)](2)(-) (2,4-pydca(2)(-) = pyridine-2,4-dicarboxylate), which possesses two kinds of coordination groups, selective bond formation with the series of the first-period transition metal ions (Mn(ii), Fe(ii), Co(ii), Cu(ii), and Zn(ii)) has been accomplished.	pyridine	88-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	262-264
15627369-4	2005	on the other hand, for Mn(ii) and Fe(ii) ions, L(Cu) shows a 2-carboxylate bridging mode to form an another 1-d assembly with a repeating motif of [-M-O-C-O-CU-O-C-O-]: [ML(Cu)(H(2)O)(4)](N)() (M = Mn (7), Fe (8)).	Carbon	153-154	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-28
15627369-4	2005	on the other hand, for Mn(ii) and Fe(ii) ions, L(Cu) shows a 2-carboxylate bridging mode to form an another 1-d assembly with a repeating motif of [-M-O-C-O-CU-O-C-O-]: [ML(Cu)(H(2)O)(4)](N)() (M = Mn (7), Fe (8)).	Carbon	153-154	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-39
15627369-1	2005	By utilizing the novel metalloligand l(Cu), [Cu(2,4-pydca)(2)](2)(-) (2,4-pydca(2)(-) = pyridine-2,4-dicarboxylate), which possesses two kinds of coordination groups, selective bond formation with the series of the first-period transition metal ions (Mn(ii), Fe(ii), Co(ii), Cu(ii), and Zn(ii)) has been accomplished.	pyridine	88-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	267-273
15627369-4	2005	on the other hand, for Mn(ii) and Fe(ii) ions, L(Cu) shows a 2-carboxylate bridging mode to form an another 1-d assembly with a repeating motif of [-M-O-C-O-CU-O-C-O-]: [ML(Cu)(H(2)O)(4)](N)() (M = Mn (7), Fe (8)).	Iron	34-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-39
15627369-1	2005	By utilizing the novel metalloligand l(Cu), [Cu(2,4-pydca)(2)](2)(-) (2,4-pydca(2)(-) = pyridine-2,4-dicarboxylate), which possesses two kinds of coordination groups, selective bond formation with the series of the first-period transition metal ions (Mn(ii), Fe(ii), Co(ii), Cu(ii), and Zn(ii)) has been accomplished.	pyridine	88-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	262-264
15627369-1	2005	By utilizing the novel metalloligand l(Cu), [Cu(2,4-pydca)(2)](2)(-) (2,4-pydca(2)(-) = pyridine-2,4-dicarboxylate), which possesses two kinds of coordination groups, selective bond formation with the series of the first-period transition metal ions (Mn(ii), Fe(ii), Co(ii), Cu(ii), and Zn(ii)) has been accomplished.	pyridine	88-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	262-264
15627369-1	2005	By utilizing the novel metalloligand l(Cu), [Cu(2,4-pydca)(2)](2)(-) (2,4-pydca(2)(-) = pyridine-2,4-dicarboxylate), which possesses two kinds of coordination groups, selective bond formation with the series of the first-period transition metal ions (Mn(ii), Fe(ii), Co(ii), Cu(ii), and Zn(ii)) has been accomplished.	2,4-dicarboxylate	97-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	254-256
15627369-1	2005	By utilizing the novel metalloligand l(Cu), [Cu(2,4-pydca)(2)](2)(-) (2,4-pydca(2)(-) = pyridine-2,4-dicarboxylate), which possesses two kinds of coordination groups, selective bond formation with the series of the first-period transition metal ions (Mn(ii), Fe(ii), Co(ii), Cu(ii), and Zn(ii)) has been accomplished.	2,4-dicarboxylate	97-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	262-264
15627369-1	2005	By utilizing the novel metalloligand l(Cu), [Cu(2,4-pydca)(2)](2)(-) (2,4-pydca(2)(-) = pyridine-2,4-dicarboxylate), which possesses two kinds of coordination groups, selective bond formation with the series of the first-period transition metal ions (Mn(ii), Fe(ii), Co(ii), Cu(ii), and Zn(ii)) has been accomplished.	2,4-dicarboxylate	97-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	267-273
15627369-1	2005	By utilizing the novel metalloligand l(Cu), [Cu(2,4-pydca)(2)](2)(-) (2,4-pydca(2)(-) = pyridine-2,4-dicarboxylate), which possesses two kinds of coordination groups, selective bond formation with the series of the first-period transition metal ions (Mn(ii), Fe(ii), Co(ii), Cu(ii), and Zn(ii)) has been accomplished.	2,4-dicarboxylate	97-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	262-264
15631489-5	2005	They reveal that all vinyl radicals studied have reduction potentials more positive (E degrees &gt;or= -0.49) than that of the Co(II)/Co(I) couple of B(12) (E degrees = -0.61 V), indicating that any (chlorinated) vinyl radicals formed in the reductive dehalogenation process should be reduced to the corresponding anions by cob(I)alamin in competition with their combination with Co(II) to yield the corresponding vinylcobalamins.	Polyvinyl Chloride	21-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	380-386
15591227-0	2005	Regulation of thrombomodulin expression in human vascular smooth muscle cells by COX-2-derived prostaglandins.	Prostaglandins	95-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-86
15631489-9	2005	Reduction of the base-off forms of vinyl- and chlorovinylcobalamin models also involves the corrin pi* orbital, but reduction of the base-off dichlorovinyl- and trichlorovinylcobalamin models occurs with electron attachment to the sigma(Co)(-)(C*) orbital, yielding calculated E degrees values more positive than that of the calculated Co(II)/Co(I) couple of B(12).	chlorovinylcobalamin	46-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	336-342
15631489-9	2005	Reduction of the base-off forms of vinyl- and chlorovinylcobalamin models also involves the corrin pi* orbital, but reduction of the base-off dichlorovinyl- and trichlorovinylcobalamin models occurs with electron attachment to the sigma(Co)(-)(C*) orbital, yielding calculated E degrees values more positive than that of the calculated Co(II)/Co(I) couple of B(12).	trichlorovinylcobalamin	161-184	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	336-342
15591227-1	2005	There is concern that cyclooxygenase (COX)-2 inhibitors may promote atherothrombosis by inhibiting vascular formation of prostacyclin (PGI2) and an increased thrombotic risk of COX-2 inhibitors has been reported.	Epoprostenol	121-133	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-44
15591227-1	2005	There is concern that cyclooxygenase (COX)-2 inhibitors may promote atherothrombosis by inhibiting vascular formation of prostacyclin (PGI2) and an increased thrombotic risk of COX-2 inhibitors has been reported.	Epoprostenol	135-139	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-44
15591227-2	2005	It is widely accepted that the prothrombotic effects of COX-2 inhibitors can be explained by the removal of platelet-inhibitory PGI2.	Epoprostenol	128-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-61
15591227-4	2005	This study is the first to demonstrate a stimulation of the expression of functionally active thrombomodulin in human smooth muscle cells by prostaglandins, endogenously formed via the COX-2 pathway.	Prostaglandins	141-155	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	185-190
15624930-0	2005	Synthesis of cyclic peroxides by chemo- and regioselective peroxidation of dienes with Co(II)/O2/Et3SiH.	cyclic peroxides	13-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-96
15624930-0	2005	Synthesis of cyclic peroxides by chemo- and regioselective peroxidation of dienes with Co(II)/O2/Et3SiH.	dienes	75-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-96
15640564-2	2005	The Co(II) ion resides on a twofold axis and is coordinated by four aqua ligands defining the basal plane and by two monodentate acesulfamate ligands, via their ring N atoms, in the axial positions.	acesulfamate	129-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
15624930-0	2005	Synthesis of cyclic peroxides by chemo- and regioselective peroxidation of dienes with Co(II)/O2/Et3SiH.	triethylsilylhydride	97-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-96
15624930-1	2005	In the competitive peroxidation of mixtures of two alkenes with Co(II)/O(2)/Et(3)SiH, it was found that the relative reactivities of the alkene substrates are influenced by three major factors:.	Alkenes	51-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-70
15358613-1	2005	The proinflammatory mediator cyclooxygenase (COX)-2 and its product PGE(2) are induced in the ischemic heart, contributing to inflammatory cell infiltration, fibroblast proliferation, and cardiac hypertrophy.	Prostaglandins E	68-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-51
15358613-2	2005	PGE(2) synthesis coupled to COX-2 involves two membrane-localized PGE synthases, mPGES-1 and mPGES-2; however, it is not clear how these synthases are regulated in cardiac myocytes and fibroblasts.	Prostaglandins E	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
16168077-4	2005	However, some or all of the gastrointestinal benefit of COX-2 inhibitors may be lost in patients who receive low, cardioprotective doses of aspirin, and recent evidence suggests that some of these agents, at some doses, may be associated with an increased risk for cardiovascular adverse events compared with no therapy.	Aspirin	140-147	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-61
15641079-12	2005	Furthermore, 15d-PGJ(2) blocked IL-1beta-induced recruitment of p300 to the COX-2 promoter, which may be the mechanism for decreased histone H3 acetylation and COX-2 expression.	15d-pgj	13-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-81
15641079-3	2005	We undertook this study to investigate the effects of 15d-PGJ(2) on interleukin-1beta (IL-1beta)-induced COX-2 expression in human synovial fibroblasts (HSFs).	15d-pgj	54-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-110
15641079-8	2005	Troglitazone, a selective peroxisome proliferator-activated receptor gamma (PPARgamma) ligand, enhanced COX-2 expression, while GW9662, a specific PPARgamma antagonist, relieved the suppressive effect of 15d-PGJ(2).	Troglitazone	0-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
18365104-0	2005	Synthesis, spectroscopic and physicochemical characterization and biological activity of Co(II) and Ni(II) coordination compounds with 4-aminoantipyrine thiosemicarbazone.	4-aminoantipyrine thiosemicarbazone	135-170	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-95
15987447-2	2005	In the present study we evaluated the mechanisms by which a highly selective COX-2 inhibitor, celecoxib, affects tumor growth of two differentially invasive human breast cancer cell lines.	Celecoxib	94-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-82
15987447-6	2005	Celecoxib treatment inhibited COX-2 activity, indicated by prostaglandin E2 secretion, and caused significant growth arrest in both breast cancer cell lines.	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-35
15987447-6	2005	Celecoxib treatment inhibited COX-2 activity, indicated by prostaglandin E2 secretion, and caused significant growth arrest in both breast cancer cell lines.	Dinoprostone	59-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-35
15987447-13	2005	CONCLUSION: The disparate molecular mechanisms of celecoxib-induced growth inhibition in human breast cancer cells depends upon the level of COX-2 expression and the invasive potential of the cell lines examined.	Celecoxib	50-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	141-146
17532719-1	2005	BACKGROUND: We investigated the potential interactions between esomeprazole and a non-selective nonsteroidal anti-inflammatory drug (NSAID; naproxen) or a cyclo-oxygenase (COX)-2-selective NSAID (rofecoxib) in healthy subjects.	rofecoxib	196-205	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	155-178
15719708-1	2005	Owing to the selective inhibition of PGI2 synthesis, treatment with COX-2 inhibitors constitutes a potential risk for the increased occurrence of thrombotic cardiovascular incidents and of the first-time occurrence or a deterioration in pre-existing heart failure.	Epoprostenol	37-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-73
16372823-2	2005	Lumiracoxib possesses a carboxylic acid group that makes it weakly acidic (acid dissociation constant [pKa] 4.7), distinguishing it from other selective COX-2 inhibitors.	lumiracoxib	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	153-158
16372823-7	2005	These data suggest that lumiracoxib may be associated with reduced systemic exposure, while still reaching sites where COX-2 inhibition is required for pain relief.	lumiracoxib	24-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-124
16372823-11	2005	Major metabolites of lumiracoxib in plasma are the 5-carboxy, 4"-hydroxy and 4"-hydroxy-5-carboxy derivatives, of which only the 4"-hydroxy derivative is active and COX-2 selective.	lumiracoxib	21-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	165-170
16372823-14	2005	Lumiracoxib is selective for COX-2 compared with COX-1 in the human whole blood assay with a ratio of 515 : 1 in healthy subjects and in patients with osteoarthritis or rheumatoid arthritis.	lumiracoxib	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34
16372823-16	2005	COX-2 selectivity of lumiracoxib is associated with a reduced incidence of gastroduodenal erosions compared with naproxen and a lack of effect on both small and large bowel permeability.	lumiracoxib	21-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
16372823-16	2005	COX-2 selectivity of lumiracoxib is associated with a reduced incidence of gastroduodenal erosions compared with naproxen and a lack of effect on both small and large bowel permeability.	Naproxen	113-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
16185091-5	2005	Based on these suggestions, the COX-2 inhibitor celecoxib has been tested as a possible adjunctive therapeutic approach in the treatment of schizophrenia.	Celecoxib	48-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-37
15892673-5	2005	Selective cyclooxygenase-2 (COX-2) inhibitors represent a new group of pharmaceutical products termed "coxibs" that include meloxicam, nimesulide, etodolac and celecoxib.	Meloxicam	124-133	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
15892673-5	2005	Selective cyclooxygenase-2 (COX-2) inhibitors represent a new group of pharmaceutical products termed "coxibs" that include meloxicam, nimesulide, etodolac and celecoxib.	nimesulide	135-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
15892673-5	2005	Selective cyclooxygenase-2 (COX-2) inhibitors represent a new group of pharmaceutical products termed "coxibs" that include meloxicam, nimesulide, etodolac and celecoxib.	Etodolac	147-155	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
15892673-5	2005	Selective cyclooxygenase-2 (COX-2) inhibitors represent a new group of pharmaceutical products termed "coxibs" that include meloxicam, nimesulide, etodolac and celecoxib.	Celecoxib	160-169	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
15892673-7	2005	This is achieved through local inhibition of both enzymes (e.g. COX-1 and COX-2) responsible for the synthesis of arachidonic acid metabolites.	Arachidonic Acid	114-130	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
15892675-8	2005	Other alternative is the application or substitution of COX-2 selective inhibitors, which spare gastric mucosal prostaglandin synthesis and do not damage the gastric mucosa.	Prostaglandins	112-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-61
15892676-5	2005	COX-2 metabolites have been implicated in mediation of renin release, regulation of sodium excretion and maintenance of renal blood flow.	Sodium	84-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
15974939-4	2005	There are currently few randomized clinical trials comparing the efficacy of the 2 first-generation COX-2 selective inhibitors, celecoxib and rofecoxib, in osteoarthritis.	Celecoxib	128-137	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-105
15974940-5	2005	COX-2-selective inhibitors (Coxibs) such as celecoxib, rofecoxib or valdecoxib have been developed to achieve an equal relief of pain and inflammation as classical NSAIDs but without their risk of gastrointestinal side effects.	Celecoxib	44-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
15974940-5	2005	COX-2-selective inhibitors (Coxibs) such as celecoxib, rofecoxib or valdecoxib have been developed to achieve an equal relief of pain and inflammation as classical NSAIDs but without their risk of gastrointestinal side effects.	rofecoxib	55-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
15974940-5	2005	COX-2-selective inhibitors (Coxibs) such as celecoxib, rofecoxib or valdecoxib have been developed to achieve an equal relief of pain and inflammation as classical NSAIDs but without their risk of gastrointestinal side effects.	valdecoxib	68-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
15974942-4	2005	The selective COX-2 inhibitor rofecoxib has no effect on PG production and does not induce damage in the stomach.	rofecoxib	30-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
15974942-8	2005	COX-2 mRNA is expressed in the stomach after administration of SC-560 and indomethacin but not rofecoxib.	SC 560	63-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
15974942-8	2005	COX-2 mRNA is expressed in the stomach after administration of SC-560 and indomethacin but not rofecoxib.	Indomethacin	74-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
15974942-9	2005	The up-regulation of COX-2 expression in response to indomethacin is prevented by atropine at a dose that inhibits gastric hypermotility but not by omeprazole at an antisecretory dose.	Indomethacin	53-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-26
15974942-9	2005	The up-regulation of COX-2 expression in response to indomethacin is prevented by atropine at a dose that inhibits gastric hypermotility but not by omeprazole at an antisecretory dose.	Atropine	82-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-26
15974942-10	2005	We conclude that the gastric ulcerogenic properties of NSAIDs are not accounted for solely by the inhibition of COX-1 and require the inhibition of both COX-1 and COX-2, the inhibition of COX-1 up-regulates COX-2 expression in association with gastric hypermotility, and PGs produced by COX-2 counteract the deleterious influences of the COX-1 inhibition.	Phosphatidylglycerols	271-274	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	163-168
15974942-10	2005	We conclude that the gastric ulcerogenic properties of NSAIDs are not accounted for solely by the inhibition of COX-1 and require the inhibition of both COX-1 and COX-2, the inhibition of COX-1 up-regulates COX-2 expression in association with gastric hypermotility, and PGs produced by COX-2 counteract the deleterious influences of the COX-1 inhibition.	Phosphatidylglycerols	271-274	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	207-212
15974942-10	2005	We conclude that the gastric ulcerogenic properties of NSAIDs are not accounted for solely by the inhibition of COX-1 and require the inhibition of both COX-1 and COX-2, the inhibition of COX-1 up-regulates COX-2 expression in association with gastric hypermotility, and PGs produced by COX-2 counteract the deleterious influences of the COX-1 inhibition.	Phosphatidylglycerols	271-274	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	207-212
15974943-3	2005	Preclinical and clinical studies suggest that CINOD inhibit COX-1 and COX-2 activities while cause less adverse effects on gastrointestinal tract in comparison to conventional NSAIDs and coxibs and reduce systemic blood pressure.	cinod	46-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-75
15733024-1	2005	The dramatic withdrawal of rofecoxib on 30 September 2004, along with safety concerns about other cyclo-oxygenase (COX)-2 inhibitors (especially valdecoxib), raises important issues for clinicians, pharmaceutical companies and regulatory authorities.	rofecoxib	27-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-121
16119973-1	2005	BACKGROUND AND OBJECTIVES: Rofecoxib, a selective cyclo-oxygenase (COX)-2 inhibitor, was a widely marketed drug that was used for relief of pain and inflammation in arthritic conditions.	rofecoxib	27-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-73
16180941-2	2005	The US FDA Adverse Events Reporting System (AERS) has received reports of Stevens-Johnson syndrome and toxic epidermal necrolysis associated with the use of the recently introduced selective cyclo-oxygenase (COX)-2 inhibitor NSAIDs, two of which are also sulfonamides.	Sulfonamides	255-267	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	191-214
16180941-3	2005	OBJECTIVE: The objective of this study is to review cases of Stevens-Johnson syndrome and toxic epidermal necrolysis reported to the FDA associated with the use of the selective COX-2 inhibitor NSAIDs celecoxib, rofecoxib and valdecoxib, and to compare reporting rates of the two conditions associated with these drugs to each other, meloxicam (an oxicam NSAID that came on the US market at a similar time) and the background incidence rate.	rofecoxib	212-221	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	178-183
16180941-3	2005	OBJECTIVE: The objective of this study is to review cases of Stevens-Johnson syndrome and toxic epidermal necrolysis reported to the FDA associated with the use of the selective COX-2 inhibitor NSAIDs celecoxib, rofecoxib and valdecoxib, and to compare reporting rates of the two conditions associated with these drugs to each other, meloxicam (an oxicam NSAID that came on the US market at a similar time) and the background incidence rate.	valdecoxib	226-236	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	178-183
16180941-3	2005	OBJECTIVE: The objective of this study is to review cases of Stevens-Johnson syndrome and toxic epidermal necrolysis reported to the FDA associated with the use of the selective COX-2 inhibitor NSAIDs celecoxib, rofecoxib and valdecoxib, and to compare reporting rates of the two conditions associated with these drugs to each other, meloxicam (an oxicam NSAID that came on the US market at a similar time) and the background incidence rate.	Meloxicam	334-343	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	178-183
16180941-3	2005	OBJECTIVE: The objective of this study is to review cases of Stevens-Johnson syndrome and toxic epidermal necrolysis reported to the FDA associated with the use of the selective COX-2 inhibitor NSAIDs celecoxib, rofecoxib and valdecoxib, and to compare reporting rates of the two conditions associated with these drugs to each other, meloxicam (an oxicam NSAID that came on the US market at a similar time) and the background incidence rate.	oxicam	337-343	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	178-183
16180941-10	2005	CONCLUSION: There is a strong association between Stevens-Johnson syndrome/toxic epidermal necrolysis and the use of the sulfonamide COX-2 inhibitors, particularly valdecoxib.	valdecoxib	164-174	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	133-138
15813652-3	2005	COX-2 inhibitors increase the risk of serious gastroduodenal adverse reactions but there is evidence that they carry a lower risk for these adverse effects than standard NSAIDs, except when there is concurrent aspirin use.	Aspirin	210-217	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
15813652-6	2005	The adverse reaction profile of the COX-2 inhibitors has confirmed the role of the COX-2 enzyme in renal function, salt and water homeostasis and the vascular endothelium.	Salts	115-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-41
15813652-6	2005	The adverse reaction profile of the COX-2 inhibitors has confirmed the role of the COX-2 enzyme in renal function, salt and water homeostasis and the vascular endothelium.	Salts	115-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
15813652-6	2005	The adverse reaction profile of the COX-2 inhibitors has confirmed the role of the COX-2 enzyme in renal function, salt and water homeostasis and the vascular endothelium.	Water	124-129	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-41
15813652-6	2005	The adverse reaction profile of the COX-2 inhibitors has confirmed the role of the COX-2 enzyme in renal function, salt and water homeostasis and the vascular endothelium.	Water	124-129	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
15813652-13	2005	Important interactions with COX-2 inhibitors in the elderly include those with warfarin, which can result in loss of control of anticoagulation, and those with ACE inhibitors, angiotensin II type 1 receptor antagonists and diuretics, which can result in loss of control of blood pressure and cardiac failure and, in hypovolaemic conditions, renal failure.	Warfarin	79-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
15903352-6	2005	Both the gastric and renal toxicities induced by traditional NSAIDs and selective COX-2 inhibitors seem to be related to inhibition of prostaglandin, but not leukotriene, synthesis.	Prostaglandins	135-148	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
15903352-6	2005	Both the gastric and renal toxicities induced by traditional NSAIDs and selective COX-2 inhibitors seem to be related to inhibition of prostaglandin, but not leukotriene, synthesis.	Leukotrienes	158-169	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
16128596-1	2005	BACKGROUND AND AIM: Because in vitro studies have shown that nimesulide not only preferentially inhibits COX-2 but also reduces the action/release of pro-inflammatory cytokines, down-regulates the synthesis and/or activity of collagenase(s), and releases reactive oxygen species and other toxic substances from neutrophils, this study investigated whether nimesulide and ibuprofen could affect levels of biochemical markers of joint inflammation and collagen catabolism in patients with flare-up of knee or hip osteoarthritis.	nimesulide	61-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-110
15652362-0	2005	Synthesis and biological evaluation of new phenidone analogues as potential dual cyclooxygenase (COX-1 and COX-2) and human lipoxygenase (5-LOX) inhibitors.	phenidone	43-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-112
15658766-3	2005	We report, herein, the preparation of gel-like metallo-supramolecular polymers prepared from a monomer unit, which consists of a 2,6-bis-(benzimidazolyl)-4-hydroxypyridine unit attached to either end of a polyether chain, mixed with a lanthanoid metal (e.g. La(III), Eu(III)) and a transition metal ion (e.g. Co(II) or Zn(II)).	Metals	47-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	309-315
15582199-2	2005	Physiologically relevant concentrations of desoxycholate (DOC) and chenodesoxycholate (CDC) upregulated expression of c-fos and COX-2 in a concentration- and time-dependent manner.	desoxycholate	43-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	128-133
15582199-2	2005	Physiologically relevant concentrations of desoxycholate (DOC) and chenodesoxycholate (CDC) upregulated expression of c-fos and COX-2 in a concentration- and time-dependent manner.	Desoxycorticosterone	58-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	128-133
15582199-2	2005	Physiologically relevant concentrations of desoxycholate (DOC) and chenodesoxycholate (CDC) upregulated expression of c-fos and COX-2 in a concentration- and time-dependent manner.	chenodesoxycholate	67-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	128-133
15582199-2	2005	Physiologically relevant concentrations of desoxycholate (DOC) and chenodesoxycholate (CDC) upregulated expression of c-fos and COX-2 in a concentration- and time-dependent manner.	CINNAMYL-3,4-DIHYDROXY-ALPHA-CYANOCINNAMATE	87-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	128-133
15663617-2	2005	Rofecoxib is a selective cyclo-oxygenase (COX)-2 inhibitor, now being increasingly used in place of nonselective nonsteroidal anti-inflammatory drugs (NSAIDs).	rofecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-48
16304418-1	2005	Selective inhibitors of cyclooxygenase (COX)-2, the coxibs, were developed to inhibit inflammatory prostaglandins derived from COX-2, while sparing gastroprotective prostaglandins primarily formed by COX-1.	Prostaglandins	99-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	127-132
16304418-2	2005	However, COX-2-derived prostaglandins mediate not only pain and inflammation but also affect vascular function, the regulation of hemostasis/ thrombosis, and blood pressure control.	Prostaglandins	23-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	9-14
16304418-3	2005	All coxibs depress COX-2-dependent prostacyclin (PGI(2)) biosynthesis without effective suppression of platelet COX-1-derived thromboxane (Tx) A(2), unlike aspirin or traditional nonsteroidal anti-inflammatory drugs, which inhibit both COX-1 and COX-2.	Epoprostenol	35-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-24
16304418-3	2005	All coxibs depress COX-2-dependent prostacyclin (PGI(2)) biosynthesis without effective suppression of platelet COX-1-derived thromboxane (Tx) A(2), unlike aspirin or traditional nonsteroidal anti-inflammatory drugs, which inhibit both COX-1 and COX-2.	Epoprostenol	49-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-24
16035651-1	2005	The aim of the study was to investigate the effects of the cylooxygenase (COX)-2 specific inhibitor rofecoxib, on blood pressure (BP) and heart rate (HR) in patients with well-controlled hypertension and osteoarthritis via 24-h ambulatory monitoring.	rofecoxib	100-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-80
17462298-6	2005	The COX-2 pathway may therefore be a useful target for chemoprevention of prostate cancer, and there is much interest in exploring this with the use of COX-2 inhibitor drugs such as celecoxib.	Celecoxib	182-191	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-157
15794489-3	2005	Maximum metal ion adsorption capacity of these hydrogels was found to be 3.64 mmol/g dry gel for Cu(II) and 1.72 mmol/g dry gel for Co(II) leading to GOx adsorption capacities of 343 and 528 mg enzyme/g dry gel, respectively, as compared to 228 mg for the plain dry PVIm gel.	Metals	8-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-138
15794489-6	2005	In phosphate buffer solution, however, stability of enzyme has been found to be significantly high reaching 90% retained activity at the end of a 40-day period at 4 degrees C for Co(II) chelated systems.	Phosphates	3-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	179-185
15641079-12	2005	Furthermore, 15d-PGJ(2) blocked IL-1beta-induced recruitment of p300 to the COX-2 promoter, which may be the mechanism for decreased histone H3 acetylation and COX-2 expression.	15d-pgj	13-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	160-165
15641079-13	2005	In accordance with this, overexpression of p300, but not of a mutant p300 lacking HAT activity, relieved the inhibitory effect of 15d-PGJ(2) on COX-2 promoter activation.	15d-pgj	130-137	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	144-149
15641079-14	2005	CONCLUSION: These data suggest that 15d-PGJ(2) can inhibit IL-1beta-induced COX-2 expression by an HDAC-independent mechanism, probably by interfering with HAT p300.	15d-pgj	36-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-81
15592025-1	2005	PURPOSE: Prostaglandin E2, produced by cyclooxygenase (COX)-2, affects the behavior of tumor cells possibly through 1 of the prostaglandin E2 receptors, the EP4 receptor (EP4R).	Dinoprostone	9-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-61
16416603-8	2005	Reporter assays indicated that EGCG inhibited the transcriptional activities of the COX-2, AP-1, and NF-kappaB promoters.	epigallocatechin gallate	31-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-89
16416603-9	2005	EGCG also caused a decrease in production of PGE2, a major product of COX-2.	epigallocatechin gallate	0-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-75
16416603-9	2005	EGCG also caused a decrease in production of PGE2, a major product of COX-2.	Dinoprostone	45-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-75
16416603-10	2005	With a longer incubation time, 96 hours, a very low dose (1.0 microg/ml) of EGCG also caused inhibition of cell growth, inhibition of activation of EGFR, HER2, and HER3, a decrease in the levels of COX-2 and Bcl-xL proteins, and apoptosis.	epigallocatechin gallate	76-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	198-203
16416603-11	2005	These results provide the first evidence that a low concentration of EGCG can inhibit activation of, at least, three members of the EGFR family of RTKs, and also inhibit COX-2 expression in colon cancer cells.	epigallocatechin gallate	69-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	170-175
16433205-3	2005	Celecoxib (CE) is a novel drug, with high selectivity and affinity for COX-2 enzyme.	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-76
15623844-0	2005	beta-Carotene downregulates the steady-state and heregulin-alpha-induced COX-2 pathways in colon cancer cells.	beta Carotene	0-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-78
15623844-2	2005	Because COX-2 has been implicated as a causative factor in colon carcinogenesis, the present study was designed to investigate the relation between the growth-inhibitory effect of the carotenoid and COX-2 expression in colon cancer cells.	Carotenoids	184-194	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	8-13
15623844-2	2005	Because COX-2 has been implicated as a causative factor in colon carcinogenesis, the present study was designed to investigate the relation between the growth-inhibitory effect of the carotenoid and COX-2 expression in colon cancer cells.	Carotenoids	184-194	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	199-204
15623844-5	2005	beta-Carotene (0.5-2.0 micromol/L) decreased COX-2 expression (P &lt; 0.05) and prostaglandin E(2) (PGE(2)) production (P &lt; 0.05) in colon cancer cells.	beta Carotene	0-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-50
15623844-7	2005	The downregulation of COX-2 by the carotenoid occurred in both untreated and heregulin-treated cells.	Carotenoids	35-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-27
15623844-10	2005	Here, we report that the suppression of COX-2 by beta-carotene may represent a molecular mechanism by which this compound acts as an antitumor agent in colon carcinogenesis.	beta Carotene	49-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
15475569-9	2005	Lead compounds, 4-chloro-N-phenylanthranilic acid and 4-benzoyl-benzoic acid for the N-phenylanthranilic acid analogs and most steroid carboxylates, exhibited IC(50) values that had greater than 500-fold selectivity for AKR1C isozymes compared with COX-1 and COX-2.	4-benzoylbenzoic acid	54-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	259-264
16218482-5	2005	Studies from our group suggest that variable expression of upstream and downstream enzymes in the prostanoid biosynthesis may represent important determinants of the functional consequences of COX-2 expression and inhibition in different clinical settings.	Prostaglandins	98-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	193-198
16218485-2	2005	MMP biosynthesis is mediated by prostaglandin (PG)E2, the product of cyclooxygenase (COX)-2/inducible PGE synthase (mPGES) activity.	Dinoprostone	32-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-91
15657353-8	2005	Furthermore, both MAPK inhibitors significantly augmented sulindac sulfide-induced apoptosis, as did suppression of constitutive COX-2 using antisense oligonucleotides.	Oligonucleotides	151-167	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-134
15657353-9	2005	In conclusion, MEK/ERK and p38 MAPK activation mediate COX-2 induction by sulindac sulfide.	sulindac sulfide	74-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-60
15475569-9	2005	Lead compounds, 4-chloro-N-phenylanthranilic acid and 4-benzoyl-benzoic acid for the N-phenylanthranilic acid analogs and most steroid carboxylates, exhibited IC(50) values that had greater than 500-fold selectivity for AKR1C isozymes compared with COX-1 and COX-2.	fenamic acid	25-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	259-264
15475569-9	2005	Lead compounds, 4-chloro-N-phenylanthranilic acid and 4-benzoyl-benzoic acid for the N-phenylanthranilic acid analogs and most steroid carboxylates, exhibited IC(50) values that had greater than 500-fold selectivity for AKR1C isozymes compared with COX-1 and COX-2.	Steroids	127-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	259-264
15692221-1	2005	BACKGROUND/AIMS: Water diuresis usually increases medullary oxygenation as a result of increased medullary synthesis of prostaglandins, but it is not clear whether this involves activation of cyclooxygenase-1 (COX-1) or cyclooxygenase-2 (COX-2).	Water	17-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	238-243
15692221-8	2005	CONCLUSION: Renal medullary oxygenation is improved by water diuresis in normal young women in a way that is blocked by a selective inhibitor of COX-2 as well as non-selective cyclooxygenase inhibitors.	Water	55-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-150
15789535-5	2005	We report two cases of tubulointersticial nephritis confirmed by renal biopsy, associated with administration of the two Cox-2 inhibitors currently available on the market, celecoxib and rofecoxib.	Celecoxib	173-182	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-126
15789535-5	2005	We report two cases of tubulointersticial nephritis confirmed by renal biopsy, associated with administration of the two Cox-2 inhibitors currently available on the market, celecoxib and rofecoxib.	rofecoxib	187-196	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-126
15749634-5	2005	Butyrate, which is anticarcinogenic, resulted in an 85% down-regulation of Cox-2 and a 37-fold increase in Cox-1 transcription.	Butyrates	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
15749634-6	2005	Propionate gave similar results (72% reduction of Cox-2, 23-fold induction of Cox-1), but lactate and acetate had no effect on Cox expression profile.	Propionates	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-55
15749634-8	2005	420, which produces acetate and lactate but no butyrate or propionate, shared the Cox-1-increasing and Cox-2-silencing properties of butyrate and propionate, whereas L. acidophilus was similar to E. coli and S. enteritidis in having no effect on the Cox-1/Cox-2 ratio.	Butyrates	133-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-108
15749634-8	2005	420, which produces acetate and lactate but no butyrate or propionate, shared the Cox-1-increasing and Cox-2-silencing properties of butyrate and propionate, whereas L. acidophilus was similar to E. coli and S. enteritidis in having no effect on the Cox-1/Cox-2 ratio.	Propionates	146-156	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-108
15821352-1	2005	OBJECTIVE: The cyclooxygenases (COX) 1 and 2 are the rate-limiting enzymes of prostaglandin E(2) (PGE(2)) synthesis, and the upregulation of COX-2 has been reported in tumors of different origins.	Dinoprostone	78-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	141-146
15821352-1	2005	OBJECTIVE: The cyclooxygenases (COX) 1 and 2 are the rate-limiting enzymes of prostaglandin E(2) (PGE(2)) synthesis, and the upregulation of COX-2 has been reported in tumors of different origins.	Dinoprostone	98-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	141-146
16015035-5	2005	Growth inhibition and the expression of VEGF and VEGFR-2 were compared after treatment with the COX-2 inhibitor, NS-398 at doses ranging from 5 to 100 microM.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	113-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-101
16015035-10	2005	CONCLUSION: The autocrine VEGF/VEGFR-2 growth pathway could be a COX-2-independent target of the COX-2 inhibitor, NS-398, in colon cancer cells.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	114-120	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-70
16015035-10	2005	CONCLUSION: The autocrine VEGF/VEGFR-2 growth pathway could be a COX-2-independent target of the COX-2 inhibitor, NS-398, in colon cancer cells.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	114-120	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
16210874-4	2005	COX-2-derived bioactive lipids, including the primary prostaglandin (PG) generated in colorectal tumors, PGE(2), are known to stimulate cell migration, proliferation and tumor-associated neovascularization while inhibiting cell death.	Prostaglandins	54-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
15657353-5	2005	Similar results were seen in HCT-15 cells and also with the selective COX-2 inhibitor NS398.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	86-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-75
16210874-4	2005	COX-2-derived bioactive lipids, including the primary prostaglandin (PG) generated in colorectal tumors, PGE(2), are known to stimulate cell migration, proliferation and tumor-associated neovascularization while inhibiting cell death.	Prostaglandins	69-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
15657353-7	2005	Selective inhibitors of sulindac sulfide-induced ERKp44/42 (PD98059) and p38 MAPK (SB203580) activation also suppressed the induction of COX-2 by this NSAID.	sulindac sulfide	24-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-142
16210874-4	2005	COX-2-derived bioactive lipids, including the primary prostaglandin (PG) generated in colorectal tumors, PGE(2), are known to stimulate cell migration, proliferation and tumor-associated neovascularization while inhibiting cell death.	Prostaglandins E	105-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
15657353-7	2005	Selective inhibitors of sulindac sulfide-induced ERKp44/42 (PD98059) and p38 MAPK (SB203580) activation also suppressed the induction of COX-2 by this NSAID.	SB 203580	83-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-142
16210874-5	2005	Here we briefly review the role of NSAIDs in preventing CRC, as well as the proposed mechanism by which a COX-2-derived PG, PGE(2), promotes colon cancer.	Prostaglandins	120-122	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-111
16210874-5	2005	Here we briefly review the role of NSAIDs in preventing CRC, as well as the proposed mechanism by which a COX-2-derived PG, PGE(2), promotes colon cancer.	Prostaglandins E	124-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-111
16415488-2	2005	The formation of prostanoids is operated by two synthases named cyclooxygenase(COX)-1 and COX-2.	Prostaglandins	17-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-95
15621371-8	2005	IL-1beta and TNFalpha treatment for 24 h enhanced prostaglandin E2 (PGE2) production 2-4-fold, which was blocked by pretreatment with the COX-2 inhibitor, NS-398.	Dinoprostone	50-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	138-143
15621371-8	2005	IL-1beta and TNFalpha treatment for 24 h enhanced prostaglandin E2 (PGE2) production 2-4-fold, which was blocked by pretreatment with the COX-2 inhibitor, NS-398.	Dinoprostone	68-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	138-143
15621371-8	2005	IL-1beta and TNFalpha treatment for 24 h enhanced prostaglandin E2 (PGE2) production 2-4-fold, which was blocked by pretreatment with the COX-2 inhibitor, NS-398.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	155-161	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	138-143
15621371-10	2005	These results indicate that TNFalpha and IL-1beta induce the functional expression of COX-2 but not EP receptors in DRG cells in culture and suggest that cytokine-induced sensitization of sensory neurons is secondary to prostaglandin production and not alterations in EP receptors.	Prostaglandins	220-233	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-91
16415488-3	2005	Traditional nonsteroidal antiinflammatory drugs (tNSAIDs) and COX-2 inhibitors (coxibs) give rise to antipyretic, analgesic, and antiinflammatory actions, through their reversible clogging of the COX channel of COX-2 - apart from aspirin which modifies irreversibly the catalytic activity of COX-2.	Aspirin	230-237	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
16415488-6	2005	COX-2 inhibitors were developed with the aim to reduce the incidence of serious gastrointestinal (GI) adverse effects associated with the administration of tNSAIDs ensued as a consequence of the inhibition of cytoprotective COX-1-derived prostanoids.	Prostaglandins	238-249	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
16415488-7	2005	However, the reduced incidence of serious GI adverse effects compared to tNSAIDs demonstrated for 2 COX-2 inhibitors (e.g. rofecoxib and lumiracoxib) has been countered by an increased incidence of myocardial infarction and stroke detected in 5 placebo controlled trials involving the COX-2 inhibitors celecoxib, rofecoxib and valdecoxib.	rofecoxib	123-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-105
16415488-7	2005	However, the reduced incidence of serious GI adverse effects compared to tNSAIDs demonstrated for 2 COX-2 inhibitors (e.g. rofecoxib and lumiracoxib) has been countered by an increased incidence of myocardial infarction and stroke detected in 5 placebo controlled trials involving the COX-2 inhibitors celecoxib, rofecoxib and valdecoxib.	rofecoxib	123-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	285-290
16415488-7	2005	However, the reduced incidence of serious GI adverse effects compared to tNSAIDs demonstrated for 2 COX-2 inhibitors (e.g. rofecoxib and lumiracoxib) has been countered by an increased incidence of myocardial infarction and stroke detected in 5 placebo controlled trials involving the COX-2 inhibitors celecoxib, rofecoxib and valdecoxib.	lumiracoxib	137-148	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-105
16415488-7	2005	However, the reduced incidence of serious GI adverse effects compared to tNSAIDs demonstrated for 2 COX-2 inhibitors (e.g. rofecoxib and lumiracoxib) has been countered by an increased incidence of myocardial infarction and stroke detected in 5 placebo controlled trials involving the COX-2 inhibitors celecoxib, rofecoxib and valdecoxib.	lumiracoxib	137-148	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	285-290
16415492-8	2005	Such data underline the role of PGI(2) as a potent mediator for regaining and maintaining the normal resting state of cells in a COX-2 dependent fashion.	Epoprostenol	32-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-134
15555528-27	2005	COX-2 drives conversion of AA to a number angiogenic and proinflammatory eicosanoids.	Eicosanoids	73-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
15574518-7	2005	Using an in vitro editing assay we find that the 3" UTR of COII, indeed, functions as a guide for both the site and number of uridines added to the coding region of the COII mRNA.	Uridine	126-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-63
16689132-3	2005	There are a lot data in the literature which suggest that selective COX-2 inhibitors (rofecoxib and celecoxib) produce the similar effects on the kidney as traditional nonsteroidal anti-inflammatory drugs (inhibitors of COX-1 and COX-2).	rofecoxib	86-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-73
16689132-3	2005	There are a lot data in the literature which suggest that selective COX-2 inhibitors (rofecoxib and celecoxib) produce the similar effects on the kidney as traditional nonsteroidal anti-inflammatory drugs (inhibitors of COX-1 and COX-2).	rofecoxib	86-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	230-235
16689132-3	2005	There are a lot data in the literature which suggest that selective COX-2 inhibitors (rofecoxib and celecoxib) produce the similar effects on the kidney as traditional nonsteroidal anti-inflammatory drugs (inhibitors of COX-1 and COX-2).	Celecoxib	100-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-73
16689132-3	2005	There are a lot data in the literature which suggest that selective COX-2 inhibitors (rofecoxib and celecoxib) produce the similar effects on the kidney as traditional nonsteroidal anti-inflammatory drugs (inhibitors of COX-1 and COX-2).	Celecoxib	100-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	230-235
15667901-2	2005	We have previously reported that the selective cyclooxygenase (COX)-2 inhibitor NS-398 inhibits ureteral contractility.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	80-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-69
15555544-0	2004	Effects of COX-2 inhibitors on ROS produced by Chlamydia pneumoniae-primed human promonocytic cells (THP-1).	Reactive Oxygen Species	31-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-16
15555544-6	2004	COX-2 inhibitors inhibited in a dose-dependent manner the luminol-enhanced CL while ibuprofen and diclofenac increased the chemiluminescence response.	Luminol	58-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
15555544-6	2004	COX-2 inhibitors inhibited in a dose-dependent manner the luminol-enhanced CL while ibuprofen and diclofenac increased the chemiluminescence response.	Ibuprofen	84-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
15555544-7	2004	By EPR spin trapping, COX-2 inhibitors, ibuprofen, and diclofenac, exhibited a dose-dependent inhibiting effect (10 and 100muM) on the EPR signal appearance.	Ibuprofen	40-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-27
15555544-7	2004	By EPR spin trapping, COX-2 inhibitors, ibuprofen, and diclofenac, exhibited a dose-dependent inhibiting effect (10 and 100muM) on the EPR signal appearance.	Diclofenac	55-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-27
15532041-8	2004	The results suggest (1) the use of SA-biotin to supplement EC adhesion enhances the integrity of the EC cytoskeleton by upregulating the expression of cytoskeleton/ECM genes, and (2) a likely relationship between the expression of cytoskeleton/ECM genes and the downstream events, such as the shear-induced expression of eNOS and COX2 genes.	sa-biotin	35-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	330-334
15471850-5	2004	Co-incubation of rat and human islets with selective COX-2 inhibitors SC-58236 and Celecoxib, respectively, attenuated cytokine-induced PGE(2) formation.	4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide	70-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-58
15471850-5	2004	Co-incubation of rat and human islets with selective COX-2 inhibitors SC-58236 and Celecoxib, respectively, attenuated cytokine-induced PGE(2) formation.	Celecoxib	83-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-58
15471850-5	2004	Co-incubation of rat and human islets with selective COX-2 inhibitors SC-58236 and Celecoxib, respectively, attenuated cytokine-induced PGE(2) formation.	Prostaglandins E	136-139	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-58
15551322-2	2004	The helicates, formulated as [Co(2)(L)(2)(L-H)(2)X(2)], readily self-assemble from a mixture of a suitable pyridine-alcohol compound (L; for example, 6-methylpyridine-2-methanol, 1), and a CoX(2) salt in the presence of base.	co(2)	30-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	189-195
15523637-3	2004	Here we demonstrate that PGJ2 enhances COX-2 gene expression without elevating COX-1 levels in neuronal cells.	9-deoxy-delta-9-prostaglandin D2	25-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-44
15523637-4	2004	PGJ2 also increased PGE2 production, establishing that the de novo synthesized COX-2 is enzymatically active.	9-deoxy-delta-9-prostaglandin D2	0-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-84
15523637-4	2004	PGJ2 also increased PGE2 production, establishing that the de novo synthesized COX-2 is enzymatically active.	Dinoprostone	20-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-84
15523637-6	2004	However, the selective PPARgamma agonist ciglitazone failed to up-regulate COX-2, indicating that the PGJ2 effect on COX-2 is PPARgamma independent.	9-deoxy-delta-9-prostaglandin D2	102-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-122
15523637-11	2004	The proinflammatory cytokine may mediate COX-2 up-regulation by PGJ2 through p38MAPK and not JNK activation, in that only an inhibitor of the former prevented the COX-2 increase.	9-deoxy-delta-9-prostaglandin D2	64-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-46
15523637-11	2004	The proinflammatory cytokine may mediate COX-2 up-regulation by PGJ2 through p38MAPK and not JNK activation, in that only an inhibitor of the former prevented the COX-2 increase.	9-deoxy-delta-9-prostaglandin D2	64-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	163-168
15523637-13	2004	Collectively, our findings suggest that proinflammatory conditions that lead to COX-2 up-regulation and the concomitant production of PGJ2 initiate a mechanism of self-destruction through an autotoxic loop between PGJ2 and COX-2 that may exacerbate neurodegeneration beyond a point of no return.	9-deoxy-delta-9-prostaglandin D2	134-138	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	223-228
15523637-13	2004	Collectively, our findings suggest that proinflammatory conditions that lead to COX-2 up-regulation and the concomitant production of PGJ2 initiate a mechanism of self-destruction through an autotoxic loop between PGJ2 and COX-2 that may exacerbate neurodegeneration beyond a point of no return.	9-deoxy-delta-9-prostaglandin D2	214-218	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-85
15581355-3	2004	In the crystal structure of INDO bound to COX-2, a small hydrophobic pocket was identified that surrounds the 2"-methyl group of INDO.	Indomethacin	28-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47
15581355-3	2004	In the crystal structure of INDO bound to COX-2, a small hydrophobic pocket was identified that surrounds the 2"-methyl group of INDO.	Indomethacin	129-133	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47
15581355-8	2004	The 2"-des-methyl analogue of INDO (DM-INDO) was synthesized and tested against wild-type COX-1 and COX-2, as well as the Val-349 mutants.	Indomethacin	30-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-105
15581355-8	2004	The 2"-des-methyl analogue of INDO (DM-INDO) was synthesized and tested against wild-type COX-1 and COX-2, as well as the Val-349 mutants.	dm-indo	36-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-105
15662752-18	2004	Several nutritional polyphenols (the secondary metabolites of plants) are COX2 and/or LOX inhibitors and iNOS activators.	Polyphenols	20-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-78
15489888-1	2004	Nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin have been shown to suppress transcription factor NF-kappaB, which controls the expression of genes such as cyclooxygenase (COX)-2 and cyclin D1, leading to inhibition of proliferation of tumor cells.	Aspirin	54-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	169-191
15579949-1	2004	The structure of the title compound, {(CH(6)N)[Co(CHO(2))(3)]}(n), consists of a three-dimensional net of central Co(II) ions connected via formate (methanediolate) bridges.	co(cho(2))	47-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-120
15648986-3	2004	The results suggest statistically better pain relief for the selective COX-2 inhibitor rofecoxib compared to tenoxicam, a traditional NSAID.	rofecoxib	87-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-76
15607056-0	2004	[Analysis of cost-minimization treatment with paracetamol or COX-2 inhibitors (rofecoxib) for pain from arthrosis of the knee or hip].	rofecoxib	79-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-66
15329330-1	2004	In human parturition, uterotonic prostaglandins (PGs) arise predominantly via increased expression of cyclooxygenase-2 (COX-2 [also known as prostaglandin synthase 2]) within intrauterine tissues.	Prostaglandins	33-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-125
15329330-1	2004	In human parturition, uterotonic prostaglandins (PGs) arise predominantly via increased expression of cyclooxygenase-2 (COX-2 [also known as prostaglandin synthase 2]) within intrauterine tissues.	Prostaglandins	49-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-125
15329330-8	2004	The 26 S proteasome inhibitor, MG-132, selectively abrogated IL-1beta-driven NFkappaB activation and COX-2 mRNA expression.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	31-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-106
15477758-4	2004	Production of the COX product, prostaglandin E2, correlated with expression of cPLA2 and COX-2 and was blocked by non-steroidal anti-inflammatory drugs (NSAIDs, indomethacin or NS398).	Dinoprostone	31-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-94
15477758-4	2004	Production of the COX product, prostaglandin E2, correlated with expression of cPLA2 and COX-2 and was blocked by non-steroidal anti-inflammatory drugs (NSAIDs, indomethacin or NS398).	Indomethacin	161-173	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-94
15477758-4	2004	Production of the COX product, prostaglandin E2, correlated with expression of cPLA2 and COX-2 and was blocked by non-steroidal anti-inflammatory drugs (NSAIDs, indomethacin or NS398).	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	177-182	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-94
15477758-7	2004	Immunofluorescence analyses revealed high-level expression of COX-2 in endothelial cells in L3.6 pl xenografts that increased following therapy with celecoxib, whereas the tumor cells expressed uniformly low levels of COX-2.	Celecoxib	149-158	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
15585639-0	2004	Inhibition of cyclooxygenase (COX)-2 expression by Tet-inducible COX-2 antisense cDNA in hormone-refractory prostate cancer significantly slows tumor growth and improves efficacy of chemotherapeutic drugs.	tetramethylenedisulfotetramine	51-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-36
15585639-0	2004	Inhibition of cyclooxygenase (COX)-2 expression by Tet-inducible COX-2 antisense cDNA in hormone-refractory prostate cancer significantly slows tumor growth and improves efficacy of chemotherapeutic drugs.	tetramethylenedisulfotetramine	51-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-70
15585639-3	2004	EXPERIMENTAL DESIGN: An antisense COX-2 cDNA construct under the control of a doxycycline-inducible promoter was transfected into a prostate cancer cell line, PC-3ML.	Doxycycline	78-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-39
15613736-3	2004	The muscarinic agent - carbachol-induced HPA response was considerably supressed by piroxicam, a predominantly constitutive cyclooxygenase (COX-1) inhibitor and significantly diminished by indomethacin, a non-selective COX blocker, but was unaffected by compound NS-398, an inducible cyclooxygenase (COX-2) antagonist.	Carbachol	23-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	300-305
15613736-3	2004	The muscarinic agent - carbachol-induced HPA response was considerably supressed by piroxicam, a predominantly constitutive cyclooxygenase (COX-1) inhibitor and significantly diminished by indomethacin, a non-selective COX blocker, but was unaffected by compound NS-398, an inducible cyclooxygenase (COX-2) antagonist.	Piroxicam	84-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	300-305
15613736-3	2004	The muscarinic agent - carbachol-induced HPA response was considerably supressed by piroxicam, a predominantly constitutive cyclooxygenase (COX-1) inhibitor and significantly diminished by indomethacin, a non-selective COX blocker, but was unaffected by compound NS-398, an inducible cyclooxygenase (COX-2) antagonist.	Indomethacin	189-201	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	300-305
15361550-7	2004	Moreover, the proapoptotic action of R(+)-MA was mimicked by the major COX-2 product PGE2.	methanandamide	37-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-76
15361550-7	2004	Moreover, the proapoptotic action of R(+)-MA was mimicked by the major COX-2 product PGE2.	Dinoprostone	85-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-76
15361550-10	2004	As a whole, this study defines COX-2 as a hitherto unknown target by which a cannabinoid induces apoptotic death of glioma cells.	Cannabinoids	77-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-36
15361550-11	2004	Furthermore, our data show that pharmacological concentrations of celecoxib may interfere with the proapoptotic action of R(+)-MA and anandamide, suggesting that cotreatment with COX-2 inhibitors could diminish glioma regression induced by these compounds.	Celecoxib	66-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	179-184
15361550-11	2004	Furthermore, our data show that pharmacological concentrations of celecoxib may interfere with the proapoptotic action of R(+)-MA and anandamide, suggesting that cotreatment with COX-2 inhibitors could diminish glioma regression induced by these compounds.	methanandamide	122-129	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	179-184
15361550-11	2004	Furthermore, our data show that pharmacological concentrations of celecoxib may interfere with the proapoptotic action of R(+)-MA and anandamide, suggesting that cotreatment with COX-2 inhibitors could diminish glioma regression induced by these compounds.	anandamide	134-144	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	179-184
15179440-0	2004	Prevention of heterotopic ossification after spinal cord injury with COX-2 selective inhibitor (rofecoxib).	rofecoxib	96-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-74
15179440-5	2004	Among them, 39 patients received placebo, and 37 received COX-2-selective inhibitor rofecoxib 25 mg daily for a period of 4 weeks.	rofecoxib	84-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
15179440-13	2004	CONCLUSION: Our data suggest that COX-2-selective inhibitor rofecoxib is an effective medication in prevention of HO after SCI.	rofecoxib	60-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-39
15537300-5	2004	The galactosyl diacylglycerols 1-3 inhibited the cyclooxygenase-1 (COX-1) enzyme by 78, 63, and 93% and the cyclooxygenase-2 (COX-2) enzyme by 87, 74, and 95%, respectively.	diacylgalactosylglycerol	4-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-131
15494133-6	2004	Levels of PGE-M in healthy humans are suppressed significantly not only by the nonselective COX inhibitor ibuprofen but also by the COX-2 selective inhibitor rofecoxib, suggesting that the majority of PGE2 formed in vivo is derived from COX-2.	Prostaglandins E	10-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-137
15494133-6	2004	Levels of PGE-M in healthy humans are suppressed significantly not only by the nonselective COX inhibitor ibuprofen but also by the COX-2 selective inhibitor rofecoxib, suggesting that the majority of PGE2 formed in vivo is derived from COX-2.	Prostaglandins E	10-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	237-242
15494133-6	2004	Levels of PGE-M in healthy humans are suppressed significantly not only by the nonselective COX inhibitor ibuprofen but also by the COX-2 selective inhibitor rofecoxib, suggesting that the majority of PGE2 formed in vivo is derived from COX-2.	rofecoxib	158-167	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-137
15494133-6	2004	Levels of PGE-M in healthy humans are suppressed significantly not only by the nonselective COX inhibitor ibuprofen but also by the COX-2 selective inhibitor rofecoxib, suggesting that the majority of PGE2 formed in vivo is derived from COX-2.	rofecoxib	158-167	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	237-242
15494133-8	2004	Levels of PGE-M were found to be greatly increased in humans with unresectable non-small cell cancer of the lung, and this increase is dramatically reduced by administration of the COX-2 inhibitor celecoxib, implying that COX-2 contributes significantly to the overproduction of PGE2.	Prostaglandins E	10-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	181-186
15494133-8	2004	Levels of PGE-M were found to be greatly increased in humans with unresectable non-small cell cancer of the lung, and this increase is dramatically reduced by administration of the COX-2 inhibitor celecoxib, implying that COX-2 contributes significantly to the overproduction of PGE2.	Prostaglandins E	10-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	222-227
15494133-8	2004	Levels of PGE-M were found to be greatly increased in humans with unresectable non-small cell cancer of the lung, and this increase is dramatically reduced by administration of the COX-2 inhibitor celecoxib, implying that COX-2 contributes significantly to the overproduction of PGE2.	Celecoxib	197-206	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	181-186
15494133-8	2004	Levels of PGE-M were found to be greatly increased in humans with unresectable non-small cell cancer of the lung, and this increase is dramatically reduced by administration of the COX-2 inhibitor celecoxib, implying that COX-2 contributes significantly to the overproduction of PGE2.	Celecoxib	197-206	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	222-227
15494133-8	2004	Levels of PGE-M were found to be greatly increased in humans with unresectable non-small cell cancer of the lung, and this increase is dramatically reduced by administration of the COX-2 inhibitor celecoxib, implying that COX-2 contributes significantly to the overproduction of PGE2.	Dinoprostone	279-283	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	181-186
15494133-8	2004	Levels of PGE-M were found to be greatly increased in humans with unresectable non-small cell cancer of the lung, and this increase is dramatically reduced by administration of the COX-2 inhibitor celecoxib, implying that COX-2 contributes significantly to the overproduction of PGE2.	Dinoprostone	279-283	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	222-227
15355999-2	2004	In the present study, we investigated the role of lipid peroxidation products in the up-regulation of COX-2, an inducible isoform responsible for high levels of prostaglandin production during inflammation and immune responses.	Prostaglandins	161-174	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-107
15355999-3	2004	COX-2 was found to colocalize with 4-hydroxy-2-nonenal (HNE), a major lipid peroxidation-derived aldehyde, in foamy macrophages within human atheromatous lesions, suggesting that COX-2 expression may be associated with the accumulation of lipid peroxidation products within macrophages.	4-hydroxy-2-nonenal	35-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
15355999-3	2004	COX-2 was found to colocalize with 4-hydroxy-2-nonenal (HNE), a major lipid peroxidation-derived aldehyde, in foamy macrophages within human atheromatous lesions, suggesting that COX-2 expression may be associated with the accumulation of lipid peroxidation products within macrophages.	4-hydroxy-2-nonenal	35-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	179-184
15355999-3	2004	COX-2 was found to colocalize with 4-hydroxy-2-nonenal (HNE), a major lipid peroxidation-derived aldehyde, in foamy macrophages within human atheromatous lesions, suggesting that COX-2 expression may be associated with the accumulation of lipid peroxidation products within macrophages.	Aldehydes	97-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
15319438-4	2004	Tunicamycin and brefeldin A, two ER stress inducers, increased the expression of COX-2 in ML-1 or MCF-7 cells.	Tunicamycin	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-86
15319438-4	2004	Tunicamycin and brefeldin A, two ER stress inducers, increased the expression of COX-2 in ML-1 or MCF-7 cells.	Brefeldin A	16-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-86
15347673-1	2004	Cyclooxygenase (COX)-1- and COX-2-derived prostaglandins are implicated in the development and progression of several malignancies.	Prostaglandins	42-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
15374627-6	2004	Meanwhile, the overexpression of COX-2, and less consistently, the upstream and downstream enzymes of the prostaglandin synthesis pathway, was demonstrated in multiple cancer types and some pre-neoplastic lesions.	Prostaglandins	106-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-38
15374627-7	2004	Direct interactions of prostaglandins with their receptors through autocrine or paracrine pathways to enhance cellular survival or stimulate angiogenesis have been proposed as the molecular mechanisms underlying the pro-carcinogenic functions of COX-2.	Prostaglandins	23-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	246-251
15510260-7	2004	A rare example of two interpenetrating 6(4)8(2)-b (quartz-like) chiral networks in 1 results from both dcbp carboxylate groups coordinating in a monodentate fashion to adjacent Co(II) centres, whereas in 2 only one carboxylate group bridges between adjacent Co(II) centres giving rise to a single chiral (10,3)-a net.	dcbp carboxylate	103-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	177-183
15510260-7	2004	A rare example of two interpenetrating 6(4)8(2)-b (quartz-like) chiral networks in 1 results from both dcbp carboxylate groups coordinating in a monodentate fashion to adjacent Co(II) centres, whereas in 2 only one carboxylate group bridges between adjacent Co(II) centres giving rise to a single chiral (10,3)-a net.	dcbp carboxylate	103-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	258-264
15510260-7	2004	A rare example of two interpenetrating 6(4)8(2)-b (quartz-like) chiral networks in 1 results from both dcbp carboxylate groups coordinating in a monodentate fashion to adjacent Co(II) centres, whereas in 2 only one carboxylate group bridges between adjacent Co(II) centres giving rise to a single chiral (10,3)-a net.	carboxylate	108-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	177-183
15510260-7	2004	A rare example of two interpenetrating 6(4)8(2)-b (quartz-like) chiral networks in 1 results from both dcbp carboxylate groups coordinating in a monodentate fashion to adjacent Co(II) centres, whereas in 2 only one carboxylate group bridges between adjacent Co(II) centres giving rise to a single chiral (10,3)-a net.	carboxylate	108-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	258-264
15510262-2	2004	In every case, X-ray crystallography reveals that the "apical" Co(II) ion has a fac tris-chelate geometry, whereas the other three Co(II) ions have mer tris-chelate geometries, resulting in (non-crystallographic)C(3) symmetry for the cages; that this structure is retained in solution is confirmed by (1)H NMR spectroscopy of the paramagnetic cages.	Tromethamine	84-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-69
15510262-2	2004	In every case, X-ray crystallography reveals that the "apical" Co(II) ion has a fac tris-chelate geometry, whereas the other three Co(II) ions have mer tris-chelate geometries, resulting in (non-crystallographic)C(3) symmetry for the cages; that this structure is retained in solution is confirmed by (1)H NMR spectroscopy of the paramagnetic cages.	Tromethamine	152-156	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-137
15476855-9	2004	Evidence from both in vitro and in vivo experiments support that NO and its reactive metabolite peroxynitrite stimulate COX-2 activity leading generation of tumor growth enhancing prostaglandins.	Peroxynitrous Acid	96-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-125
15476855-9	2004	Evidence from both in vitro and in vivo experiments support that NO and its reactive metabolite peroxynitrite stimulate COX-2 activity leading generation of tumor growth enhancing prostaglandins.	Prostaglandins	180-194	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-125
15623263-0	2004	COX-2 inhibitor use after Vioxx: careful balance or end of the rope?	rofecoxib	26-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
15546559-1	2004	BACKGROUND: We hypothesized that combined treatment with cyclooxygenase (Cox)-1 (catechin) and Cox-2 (NS398)-specific inhibitors would reduce cellular proliferation synergistically in genitourinary cancer.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	102-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-100
15533902-1	2004	BACKGROUND: Cyclooxygenase enzymes (COX-1, COX-2, and COX-3) convert arachidonic acid to prostaglandins, prostacyclins, thromboxanes, and other hydroxy fatty acids.	Arachidonic Acid	69-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
15533902-1	2004	BACKGROUND: Cyclooxygenase enzymes (COX-1, COX-2, and COX-3) convert arachidonic acid to prostaglandins, prostacyclins, thromboxanes, and other hydroxy fatty acids.	Prostaglandins	89-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
15533902-1	2004	BACKGROUND: Cyclooxygenase enzymes (COX-1, COX-2, and COX-3) convert arachidonic acid to prostaglandins, prostacyclins, thromboxanes, and other hydroxy fatty acids.	Prostaglandins I	105-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
15533902-1	2004	BACKGROUND: Cyclooxygenase enzymes (COX-1, COX-2, and COX-3) convert arachidonic acid to prostaglandins, prostacyclins, thromboxanes, and other hydroxy fatty acids.	Thromboxanes	120-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
15533902-1	2004	BACKGROUND: Cyclooxygenase enzymes (COX-1, COX-2, and COX-3) convert arachidonic acid to prostaglandins, prostacyclins, thromboxanes, and other hydroxy fatty acids.	hydroxy fatty acids	144-163	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
15533902-3	2004	The COX-2 isoform is the primary enzyme involved in PGE(2) production in cancerous tissue.	Dinoprostone	52-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
15533902-4	2004	OBJECTIVE/HYPOTHESIS: We administered the COX-2 inhibitor celecoxib (200 mg b.i.d.)	Celecoxib	58-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47
15540943-11	2004	The conditional binding constants determined for Co(II) and Cd(II) in 50 mM phosphate buffer, pH 7.4, are 10(7.4)+/-(0.4) and 10(12.8)+/-(0.5), respectively, yielding binding constant ratios Zn(II)/Co(II) of 100 and Zn(II)/ Cd(II) of 0.001, which are the lowest values reported for zinc fingers so far.	cd(ii)	60-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-55
15540943-11	2004	The conditional binding constants determined for Co(II) and Cd(II) in 50 mM phosphate buffer, pH 7.4, are 10(7.4)+/-(0.4) and 10(12.8)+/-(0.5), respectively, yielding binding constant ratios Zn(II)/Co(II) of 100 and Zn(II)/ Cd(II) of 0.001, which are the lowest values reported for zinc fingers so far.	cd(ii)	60-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	198-204
15540943-11	2004	The conditional binding constants determined for Co(II) and Cd(II) in 50 mM phosphate buffer, pH 7.4, are 10(7.4)+/-(0.4) and 10(12.8)+/-(0.5), respectively, yielding binding constant ratios Zn(II)/Co(II) of 100 and Zn(II)/ Cd(II) of 0.001, which are the lowest values reported for zinc fingers so far.	Phosphates	76-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-55
15540943-11	2004	The conditional binding constants determined for Co(II) and Cd(II) in 50 mM phosphate buffer, pH 7.4, are 10(7.4)+/-(0.4) and 10(12.8)+/-(0.5), respectively, yielding binding constant ratios Zn(II)/Co(II) of 100 and Zn(II)/ Cd(II) of 0.001, which are the lowest values reported for zinc fingers so far.	Phosphates	76-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	198-204
15540943-11	2004	The conditional binding constants determined for Co(II) and Cd(II) in 50 mM phosphate buffer, pH 7.4, are 10(7.4)+/-(0.4) and 10(12.8)+/-(0.5), respectively, yielding binding constant ratios Zn(II)/Co(II) of 100 and Zn(II)/ Cd(II) of 0.001, which are the lowest values reported for zinc fingers so far.	Zinc	191-193	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-55
15540943-11	2004	The conditional binding constants determined for Co(II) and Cd(II) in 50 mM phosphate buffer, pH 7.4, are 10(7.4)+/-(0.4) and 10(12.8)+/-(0.5), respectively, yielding binding constant ratios Zn(II)/Co(II) of 100 and Zn(II)/ Cd(II) of 0.001, which are the lowest values reported for zinc fingers so far.	Zinc	191-197	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-55
15540943-11	2004	The conditional binding constants determined for Co(II) and Cd(II) in 50 mM phosphate buffer, pH 7.4, are 10(7.4)+/-(0.4) and 10(12.8)+/-(0.5), respectively, yielding binding constant ratios Zn(II)/Co(II) of 100 and Zn(II)/ Cd(II) of 0.001, which are the lowest values reported for zinc fingers so far.	cd(ii)	224-230	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-55
15540943-12	2004	The Co(II) ion forms a tetrahedral complex with the sulfurs of XPAzf, which is isostructural with the native zinc finger.	Sulfur	52-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
15540943-14	2004	The oxidation of Zn(II)-saturated XPAzf by H2O2 is accelerated in the presence of Co(II), but the concentration profile of this effect indicates the formation of an active Co(II) complex external to the metal-sulfur center.	Zinc	17-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-88
15540943-14	2004	The oxidation of Zn(II)-saturated XPAzf by H2O2 is accelerated in the presence of Co(II), but the concentration profile of this effect indicates the formation of an active Co(II) complex external to the metal-sulfur center.	Zinc	17-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	172-178
15540943-14	2004	The oxidation of Zn(II)-saturated XPAzf by H2O2 is accelerated in the presence of Co(II), but the concentration profile of this effect indicates the formation of an active Co(II) complex external to the metal-sulfur center.	Hydrogen Peroxide	43-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-88
15540943-14	2004	The oxidation of Zn(II)-saturated XPAzf by H2O2 is accelerated in the presence of Co(II), but the concentration profile of this effect indicates the formation of an active Co(II) complex external to the metal-sulfur center.	Hydrogen Peroxide	43-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	172-178
15540943-14	2004	The oxidation of Zn(II)-saturated XPAzf by H2O2 is accelerated in the presence of Co(II), but the concentration profile of this effect indicates the formation of an active Co(II) complex external to the metal-sulfur center.	Sulfur	209-215	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	172-178
15865061-1	2004	The selective inhibition of COX-2 isozymes should lead to a new generation of NSAIDs with significantly reduced side effects; e.g. celecoxib (Celebrex) and rofecoxib (Vioxx).	Celecoxib	131-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
15865061-1	2004	The selective inhibition of COX-2 isozymes should lead to a new generation of NSAIDs with significantly reduced side effects; e.g. celecoxib (Celebrex) and rofecoxib (Vioxx).	Celecoxib	142-150	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
15522398-0	2004	Ternary complexes metal [Co(II), Ni(II), Cu(II) and Zn(II)]--ortho-iodohippurate (I-hip)--acyclovir.	Metals	18-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-31
15522398-0	2004	Ternary complexes metal [Co(II), Ni(II), Cu(II) and Zn(II)]--ortho-iodohippurate (I-hip)--acyclovir.	Iodohippuric Acid	61-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-31
15522398-0	2004	Ternary complexes metal [Co(II), Ni(II), Cu(II) and Zn(II)]--ortho-iodohippurate (I-hip)--acyclovir.	Iodohippuric Acid	82-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-31
15522398-0	2004	Ternary complexes metal [Co(II), Ni(II), Cu(II) and Zn(II)]--ortho-iodohippurate (I-hip)--acyclovir.	Acyclovir	90-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-31
15380821-6	2004	At a low concentration of ONOO(-) (5 microM) there was enhancement of the COX-1 and -2 activities, but with higher concentrations there was suppression of these two enzyme activities (COX-1, at 200 microM; COX-2, &gt;50 microM).	onoo(-)	26-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	206-211
15576013-4	2004	Rofecoxib is the most specific COX-2 inhibitor among the first generation of the class, i.e., negligible COX-1 inhibitory effect.	rofecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-36
15576013-7	2004	It is plausible that the COX-2 inhibition is associated with altered homeostasis that is compensated with the cardioprotection effect of COX-1 inhibition that patients receive either through the less COX-2 selectivity of other NSAIDs or through co-administration of low dose aspirin.	Aspirin	275-282	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-30
15576013-10	2004	However, based on some available indirect evidence, and unless more clear-cut data become available, the use of highly COX-2 selective NSAIDs without the use of a suitable COX-1 inhibitor, (e.g., low dose aspirin) may be best avoided.	Aspirin	205-212	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-124
15500686-12	2004	Stromal immunostaining for COX-1 as well as COX-2 was increased in the TP and PP groups as compared to the NP, and GE displayed an intensely increased COX-2 immunostaining at term and postpartum.	neotetrazolium	71-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-49
15486258-1	2004	Withdrawal of Vioxx casts a shadow over COX-2 inhibitors.	rofecoxib	14-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
15673949-1	2004	AIM: to know the effect of piroxicam (COX-1 and COX-2 inhibitor NSAID) and meloxicam (selective COX-2 inhibitor NSAID) against the gastric mucosa.	Meloxicam	75-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-101
15355480-0	2004	Partial safety of the new COX-2 inhibitor rofecoxib in NSAIDs high sensitive patients.	rofecoxib	42-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-31
15521372-8	2004	The SBPCOCs with the selective COX-2 inhibitors celecoxib and rofecoxib were well tolerated in all cases.	Celecoxib	48-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-36
15521372-8	2004	The SBPCOCs with the selective COX-2 inhibitors celecoxib and rofecoxib were well tolerated in all cases.	rofecoxib	62-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-36
15521372-10	2004	CONCLUSIONS: The SBPCOCs with highly selective COX-2 inhibitors were safe in patients with single-reactive, NSAID-induced anaphylactoid reactions, even in cases that involved pyrazole derivatives.	pyrazole	175-183	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
15155531-9	2004	COX-2 mRNA expression was suppressed by quercetin and the synthetic COX-2 inhibitors in a time- and dose-dependent manner.	Quercetin	40-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
15462687-2	2004	Rofecoxib, a COX-2 specific inhibitor, was developed to provide similar efficacy and less GI toxicity than NSAIDs.	rofecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
15383564-10	2004	The effect of a COX-2 inhibition in LN-18-COX2 is reversible after administration of PGE(2).	Prostaglandins E	85-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-46
15379866-8	2004	Interestingly, selective COX-2 inhibition (NS-398), but not selective COX-1 inhibition (SC-560), exerted a stimulatory effect on the expression of pro-inflammatory cytokines.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	43-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-30
15350911-3	2004	The molar conductance measurements of the complexes in DMSO correspond to be nonelectrolytic nature for Mn(II), Co(II) and Cu(II) while 1:2 electrolytes for Ni(II) complexes.	Dimethyl Sulfoxide	55-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-118
15350911-3	2004	The molar conductance measurements of the complexes in DMSO correspond to be nonelectrolytic nature for Mn(II), Co(II) and Cu(II) while 1:2 electrolytes for Ni(II) complexes.	Nickel(2+)	157-163	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-118
15350911-5	2004	On the basis of IR, electronic and EPR spectral studies an octahedral geometry has been assigned for Mn(II) and Co(II) complexes, square-planar for Ni(II) whereas tetragonal for Cu(II) complexes.	Nickel(2+)	148-154	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-118
15350911-5	2004	On the basis of IR, electronic and EPR spectral studies an octahedral geometry has been assigned for Mn(II) and Co(II) complexes, square-planar for Ni(II) whereas tetragonal for Cu(II) complexes.	cu(ii)	178-184	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-118
15350915-1	2004	Cobalt(II) carbonate, CoCO3.4H2O and lead(II) carbonate, PbCO3.2H2O were synthesis by a new simple method during the reaction of aqueous solutions of CoX2 (X=Cl-, NO3- and CH3COO-) and PbX2 (X=NO3- or CH3COO-), respectively, with urea at approximately 85 degrees C for 2 h. The infrared spectra of the reaction products clearly indicates the absence of the bands due to coordinated urea, but show the characteristic bands of ionic carbonate.	COBALT CARBONATE	0-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	150-154
15350915-1	2004	Cobalt(II) carbonate, CoCO3.4H2O and lead(II) carbonate, PbCO3.2H2O were synthesis by a new simple method during the reaction of aqueous solutions of CoX2 (X=Cl-, NO3- and CH3COO-) and PbX2 (X=NO3- or CH3COO-), respectively, with urea at approximately 85 degrees C for 2 h. The infrared spectra of the reaction products clearly indicates the absence of the bands due to coordinated urea, but show the characteristic bands of ionic carbonate.	coco3.4h2o	22-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	150-154
15350915-1	2004	Cobalt(II) carbonate, CoCO3.4H2O and lead(II) carbonate, PbCO3.2H2O were synthesis by a new simple method during the reaction of aqueous solutions of CoX2 (X=Cl-, NO3- and CH3COO-) and PbX2 (X=NO3- or CH3COO-), respectively, with urea at approximately 85 degrees C for 2 h. The infrared spectra of the reaction products clearly indicates the absence of the bands due to coordinated urea, but show the characteristic bands of ionic carbonate.	lead carbonate	37-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	150-154
15350915-1	2004	Cobalt(II) carbonate, CoCO3.4H2O and lead(II) carbonate, PbCO3.2H2O were synthesis by a new simple method during the reaction of aqueous solutions of CoX2 (X=Cl-, NO3- and CH3COO-) and PbX2 (X=NO3- or CH3COO-), respectively, with urea at approximately 85 degrees C for 2 h. The infrared spectra of the reaction products clearly indicates the absence of the bands due to coordinated urea, but show the characteristic bands of ionic carbonate.	pbco3.2h2o	57-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	150-154
15350915-1	2004	Cobalt(II) carbonate, CoCO3.4H2O and lead(II) carbonate, PbCO3.2H2O were synthesis by a new simple method during the reaction of aqueous solutions of CoX2 (X=Cl-, NO3- and CH3COO-) and PbX2 (X=NO3- or CH3COO-), respectively, with urea at approximately 85 degrees C for 2 h. The infrared spectra of the reaction products clearly indicates the absence of the bands due to coordinated urea, but show the characteristic bands of ionic carbonate.	Urea	230-234	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	150-154
15350915-1	2004	Cobalt(II) carbonate, CoCO3.4H2O and lead(II) carbonate, PbCO3.2H2O were synthesis by a new simple method during the reaction of aqueous solutions of CoX2 (X=Cl-, NO3- and CH3COO-) and PbX2 (X=NO3- or CH3COO-), respectively, with urea at approximately 85 degrees C for 2 h. The infrared spectra of the reaction products clearly indicates the absence of the bands due to coordinated urea, but show the characteristic bands of ionic carbonate.	Urea	382-386	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	150-154
15350915-1	2004	Cobalt(II) carbonate, CoCO3.4H2O and lead(II) carbonate, PbCO3.2H2O were synthesis by a new simple method during the reaction of aqueous solutions of CoX2 (X=Cl-, NO3- and CH3COO-) and PbX2 (X=NO3- or CH3COO-), respectively, with urea at approximately 85 degrees C for 2 h. The infrared spectra of the reaction products clearly indicates the absence of the bands due to coordinated urea, but show the characteristic bands of ionic carbonate.	Carbonates	11-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	150-154
15350923-1	2004	A series of new metal complexes of Co(II), Ce(III) and UO(2)(VI), with the Schiff base ligand, H2L, bis-salicylatothiosemicarbazide have been prepared in presence of different molar ratios of LiOH.H2O as a deprotonating agent.	Metals	16-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-41
15350923-1	2004	A series of new metal complexes of Co(II), Ce(III) and UO(2)(VI), with the Schiff base ligand, H2L, bis-salicylatothiosemicarbazide have been prepared in presence of different molar ratios of LiOH.H2O as a deprotonating agent.	Schiff Bases	75-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-41
15350923-1	2004	A series of new metal complexes of Co(II), Ce(III) and UO(2)(VI), with the Schiff base ligand, H2L, bis-salicylatothiosemicarbazide have been prepared in presence of different molar ratios of LiOH.H2O as a deprotonating agent.	bis-salicylatothiosemicarbazide	100-131	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-41
15350923-1	2004	A series of new metal complexes of Co(II), Ce(III) and UO(2)(VI), with the Schiff base ligand, H2L, bis-salicylatothiosemicarbazide have been prepared in presence of different molar ratios of LiOH.H2O as a deprotonating agent.	lithium hydroxide	192-196	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-41
15350923-1	2004	A series of new metal complexes of Co(II), Ce(III) and UO(2)(VI), with the Schiff base ligand, H2L, bis-salicylatothiosemicarbazide have been prepared in presence of different molar ratios of LiOH.H2O as a deprotonating agent.	Water	197-200	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-41
16137030-4	2004	The combination of celecoxib and hydroxyurea could evidently inhibit the expression of COX-2 protein or COX-2 mRNA of K562 cells.	Celecoxib	19-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-92
16137030-4	2004	The combination of celecoxib and hydroxyurea could evidently inhibit the expression of COX-2 protein or COX-2 mRNA of K562 cells.	Celecoxib	19-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
16137030-4	2004	The combination of celecoxib and hydroxyurea could evidently inhibit the expression of COX-2 protein or COX-2 mRNA of K562 cells.	Hydroxyurea	33-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-92
16137030-4	2004	The combination of celecoxib and hydroxyurea could evidently inhibit the expression of COX-2 protein or COX-2 mRNA of K562 cells.	Hydroxyurea	33-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
16137030-5	2004	CONCLUSION: Celecoxib can enhance the anti-proliferative effect of hydroxyurea on K562 cells, which is associated with the down-regulation of both COX-2 protein and COX-2 mRNA on K562 cells.	Celecoxib	12-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-152
16137030-5	2004	CONCLUSION: Celecoxib can enhance the anti-proliferative effect of hydroxyurea on K562 cells, which is associated with the down-regulation of both COX-2 protein and COX-2 mRNA on K562 cells.	Celecoxib	12-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	165-170
15324899-2	2004	Incorporation of a conformationally more rigid 3-aroyloxy substituent onto the 6-methylsulfonylindole scaffold led to selective, but considerably less potent COX-2 inhibitors.	6-(Methylsulfonyl)-1H-indole	79-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	158-163
15324899-3	2004	Variation of the hydrophilicity and size of the indole 2-substituent of 3-arylthio-6-methylsulfonylindole inhibitors led to modulation of the COX-2 human whole blood (HWB) potency and selectivity.	3-arylthio-6-methylsulfonylindole	72-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	142-147
15535105-5	2004	However, the lack of "healing" prostaglandins as an effect of COX-2 antagonism may prevent the improvement of existing ulcers.	Prostaglandins	31-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
15210717-1	2004	Little is known about the effect of epigallocatechin-3 gallate (EGCG), a major constituent of green tea, on the expression of cyclooxygenase (COX)-2.	epigallocatechin gallate	36-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-148
15210717-1	2004	Little is known about the effect of epigallocatechin-3 gallate (EGCG), a major constituent of green tea, on the expression of cyclooxygenase (COX)-2.	epigallocatechin gallate	64-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-148
15210717-2	2004	Here, we studied the role of phospholipase D (PLD) isozymes in EGCG-induced COX-2 expression.	epigallocatechin gallate	63-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-81
15210717-3	2004	Stimulation of human astrocytoma cells (U87) with EGCG induced formation of phosphatidylbutanol, a specific product of PLD activity, and synthesis of COX-2 protein and its product, prostaglandin E(2) (PGE(2)).	epigallocatechin gallate	50-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	150-155
15210717-3	2004	Stimulation of human astrocytoma cells (U87) with EGCG induced formation of phosphatidylbutanol, a specific product of PLD activity, and synthesis of COX-2 protein and its product, prostaglandin E(2) (PGE(2)).	Dinoprostone	181-199	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	150-155
15210717-4	2004	Pretreatment of cells with 1-butanol, but not 3-butanol, suppressed EGCG-induced COX-2 expression and PGE synthesis.	1-Butanol	27-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-86
15210717-4	2004	Pretreatment of cells with 1-butanol, but not 3-butanol, suppressed EGCG-induced COX-2 expression and PGE synthesis.	epigallocatechin gallate	68-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-86
15210717-5	2004	Furthermore, evidence that PLD was involved in EGCG-induced COX-2 expression was provided by the observations that COX-2 expression was stimulated by overexpression of PLD1 or PLD2 isozymes and treatment with phosphatidic acid (PA), and that prevention of PA dephosphorylation by 1-propranolol significantly potentiated COX-2 expression induced by EGCG.	epigallocatechin gallate	47-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-65
15210717-5	2004	Furthermore, evidence that PLD was involved in EGCG-induced COX-2 expression was provided by the observations that COX-2 expression was stimulated by overexpression of PLD1 or PLD2 isozymes and treatment with phosphatidic acid (PA), and that prevention of PA dephosphorylation by 1-propranolol significantly potentiated COX-2 expression induced by EGCG.	epigallocatechin gallate	47-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-120
15210717-5	2004	Furthermore, evidence that PLD was involved in EGCG-induced COX-2 expression was provided by the observations that COX-2 expression was stimulated by overexpression of PLD1 or PLD2 isozymes and treatment with phosphatidic acid (PA), and that prevention of PA dephosphorylation by 1-propranolol significantly potentiated COX-2 expression induced by EGCG.	epigallocatechin gallate	47-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-120
15210717-5	2004	Furthermore, evidence that PLD was involved in EGCG-induced COX-2 expression was provided by the observations that COX-2 expression was stimulated by overexpression of PLD1 or PLD2 isozymes and treatment with phosphatidic acid (PA), and that prevention of PA dephosphorylation by 1-propranolol significantly potentiated COX-2 expression induced by EGCG.	Phosphatidic Acids	209-226	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-65
15210717-5	2004	Furthermore, evidence that PLD was involved in EGCG-induced COX-2 expression was provided by the observations that COX-2 expression was stimulated by overexpression of PLD1 or PLD2 isozymes and treatment with phosphatidic acid (PA), and that prevention of PA dephosphorylation by 1-propranolol significantly potentiated COX-2 expression induced by EGCG.	Phosphatidic Acids	209-226	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-120
15210717-5	2004	Furthermore, evidence that PLD was involved in EGCG-induced COX-2 expression was provided by the observations that COX-2 expression was stimulated by overexpression of PLD1 or PLD2 isozymes and treatment with phosphatidic acid (PA), and that prevention of PA dephosphorylation by 1-propranolol significantly potentiated COX-2 expression induced by EGCG.	Phosphatidic Acids	209-226	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-120
15210717-5	2004	Furthermore, evidence that PLD was involved in EGCG-induced COX-2 expression was provided by the observations that COX-2 expression was stimulated by overexpression of PLD1 or PLD2 isozymes and treatment with phosphatidic acid (PA), and that prevention of PA dephosphorylation by 1-propranolol significantly potentiated COX-2 expression induced by EGCG.	Phosphatidic Acids	228-230	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-65
15210717-5	2004	Furthermore, evidence that PLD was involved in EGCG-induced COX-2 expression was provided by the observations that COX-2 expression was stimulated by overexpression of PLD1 or PLD2 isozymes and treatment with phosphatidic acid (PA), and that prevention of PA dephosphorylation by 1-propranolol significantly potentiated COX-2 expression induced by EGCG.	Phosphatidic Acids	228-230	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-120
15210717-5	2004	Furthermore, evidence that PLD was involved in EGCG-induced COX-2 expression was provided by the observations that COX-2 expression was stimulated by overexpression of PLD1 or PLD2 isozymes and treatment with phosphatidic acid (PA), and that prevention of PA dephosphorylation by 1-propranolol significantly potentiated COX-2 expression induced by EGCG.	Phosphatidic Acids	228-230	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-120
15210717-5	2004	Furthermore, evidence that PLD was involved in EGCG-induced COX-2 expression was provided by the observations that COX-2 expression was stimulated by overexpression of PLD1 or PLD2 isozymes and treatment with phosphatidic acid (PA), and that prevention of PA dephosphorylation by 1-propranolol significantly potentiated COX-2 expression induced by EGCG.	Phosphatidic Acids	256-258	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-65
15210717-5	2004	Furthermore, evidence that PLD was involved in EGCG-induced COX-2 expression was provided by the observations that COX-2 expression was stimulated by overexpression of PLD1 or PLD2 isozymes and treatment with phosphatidic acid (PA), and that prevention of PA dephosphorylation by 1-propranolol significantly potentiated COX-2 expression induced by EGCG.	Phosphatidic Acids	256-258	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-120
15210717-5	2004	Furthermore, evidence that PLD was involved in EGCG-induced COX-2 expression was provided by the observations that COX-2 expression was stimulated by overexpression of PLD1 or PLD2 isozymes and treatment with phosphatidic acid (PA), and that prevention of PA dephosphorylation by 1-propranolol significantly potentiated COX-2 expression induced by EGCG.	Phosphatidic Acids	256-258	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-120
15210717-5	2004	Furthermore, evidence that PLD was involved in EGCG-induced COX-2 expression was provided by the observations that COX-2 expression was stimulated by overexpression of PLD1 or PLD2 isozymes and treatment with phosphatidic acid (PA), and that prevention of PA dephosphorylation by 1-propranolol significantly potentiated COX-2 expression induced by EGCG.	(S)-propranolol	280-293	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-65
15210717-5	2004	Furthermore, evidence that PLD was involved in EGCG-induced COX-2 expression was provided by the observations that COX-2 expression was stimulated by overexpression of PLD1 or PLD2 isozymes and treatment with phosphatidic acid (PA), and that prevention of PA dephosphorylation by 1-propranolol significantly potentiated COX-2 expression induced by EGCG.	(S)-propranolol	280-293	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-120
15210717-5	2004	Furthermore, evidence that PLD was involved in EGCG-induced COX-2 expression was provided by the observations that COX-2 expression was stimulated by overexpression of PLD1 or PLD2 isozymes and treatment with phosphatidic acid (PA), and that prevention of PA dephosphorylation by 1-propranolol significantly potentiated COX-2 expression induced by EGCG.	(S)-propranolol	280-293	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-120
15210717-5	2004	Furthermore, evidence that PLD was involved in EGCG-induced COX-2 expression was provided by the observations that COX-2 expression was stimulated by overexpression of PLD1 or PLD2 isozymes and treatment with phosphatidic acid (PA), and that prevention of PA dephosphorylation by 1-propranolol significantly potentiated COX-2 expression induced by EGCG.	epigallocatechin gallate	348-352	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-65
15210717-5	2004	Furthermore, evidence that PLD was involved in EGCG-induced COX-2 expression was provided by the observations that COX-2 expression was stimulated by overexpression of PLD1 or PLD2 isozymes and treatment with phosphatidic acid (PA), and that prevention of PA dephosphorylation by 1-propranolol significantly potentiated COX-2 expression induced by EGCG.	epigallocatechin gallate	348-352	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-120
15210717-5	2004	Furthermore, evidence that PLD was involved in EGCG-induced COX-2 expression was provided by the observations that COX-2 expression was stimulated by overexpression of PLD1 or PLD2 isozymes and treatment with phosphatidic acid (PA), and that prevention of PA dephosphorylation by 1-propranolol significantly potentiated COX-2 expression induced by EGCG.	epigallocatechin gallate	348-352	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-120
15210717-6	2004	EGCG induced activation of p38 mitogen-activated protein kinase (p38 MAPK), and specific inhibition of p38 MAPK dramatically abolished EGCG-induced PLD activation, COX-2 expression, and PGE(2) formation.	epigallocatechin gallate	0-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	164-169
15210717-6	2004	EGCG induced activation of p38 mitogen-activated protein kinase (p38 MAPK), and specific inhibition of p38 MAPK dramatically abolished EGCG-induced PLD activation, COX-2 expression, and PGE(2) formation.	epigallocatechin gallate	135-139	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	164-169
15210717-7	2004	Moreover, protein kinase C (PKC) inhibition suppressed EGCG-induced p38 MAPK activation, COX-2 expression, and PGE(2) accumulation.	epigallocatechin gallate	55-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-94
15210717-9	2004	Collectively, our results demonstrate for the first time that PLD isozymes mediate EGCG-induced COX-2 expression through PKC and p38 in immortalized astroglial line and normal astrocyte cells.	epigallocatechin gallate	83-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-101
15339324-0	2004	Reduced incidence of upper gastrointestinal ulcer complications with the COX-2 selective inhibitor, valdecoxib.	valdecoxib	100-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-78
15475569-9	2005	Lead compounds, 4-chloro-N-phenylanthranilic acid and 4-benzoyl-benzoic acid for the N-phenylanthranilic acid analogs and most steroid carboxylates, exhibited IC(50) values that had greater than 500-fold selectivity for AKR1C isozymes compared with COX-1 and COX-2.	4-chloro-n-phenylanthranilic acid	16-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	259-264
15563357-6	2004	Final results of the celecoxib outcome study (CLASS study) attenuated the initial enthusiasm about the GI safety of selective COX-2 inhibitors, especially in patients concomitantly taking aspirin for cardiovascular prophylaxis.	Celecoxib	21-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-131
15563357-6	2004	Final results of the celecoxib outcome study (CLASS study) attenuated the initial enthusiasm about the GI safety of selective COX-2 inhibitors, especially in patients concomitantly taking aspirin for cardiovascular prophylaxis.	Aspirin	188-195	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-131
15585639-2	2004	The significance of COX-2 in prostate cancer growth and response to chemotherapy was investigated in an androgen-refractory prostate cancer cell line using a Tet-inducible antisense COX-2 expression system.	tetramethylenedisulfotetramine	158-161	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	182-187
15534440-7	2004	Current research is addressing the COX-2 inhibitor, rofecoxib, which has theoretical advantages with respect to fetal safety.	rofecoxib	52-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40
15579005-4	2004	The search for new COX-2 inhibitors is going on, the development of etoricoxib and lumiracoxib is a step ahead concerning efficacy, tolerability and safety.	lumiracoxib	83-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-24
15701208-2	2004	OBJECTIVE: To compare the rates of new use of gastroprotective agents and discontinuations due to dyspepsia with the COX-2 selective inhibitor etoricoxib compared with non-selective NSAIDs.	Etoricoxib	143-153	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-122
15844661-5	2004	Imatinib induced expression of COX-2 in a dose-dependent manner with concomitant accumulation of prostaglandin E2.	Imatinib Mesylate	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-36
15844661-5	2004	Imatinib induced expression of COX-2 in a dose-dependent manner with concomitant accumulation of prostaglandin E2.	Dinoprostone	97-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-36
15844661-6	2004	COX-2 induction by imatinib was initiated through epidermal growth factor (EGF) receptor kinase activation and downstream signaling through mitogenic-activated protein kinase.	Imatinib Mesylate	19-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
15844661-7	2004	COX-2 induction by imatinib was blocked by MEK1 or EGF receptor inhibition.	Imatinib Mesylate	19-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
15844661-9	2004	Imatinib failed to activate EGF receptor signals in other tumor types, suggesting that COX-2 induction in imatinib-treated cells is mediated through release of autocrine factors expressed or activated in squamous tumors.	Imatinib Mesylate	106-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-92
15844661-10	2004	COX-2 induction by imatinib in squamous tumors derived from the head and neck region is unique with respect to other target-specific agents and may represent one of the unintended toxic effects of imatinib described in some patients.	Imatinib Mesylate	19-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
15844661-10	2004	COX-2 induction by imatinib in squamous tumors derived from the head and neck region is unique with respect to other target-specific agents and may represent one of the unintended toxic effects of imatinib described in some patients.	Imatinib Mesylate	197-205	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
15297470-1	2004	Administration of selective and nonselective cyclooxygenase (COX)-2 inhibitors to rheumatoid arthritis patients taking low doses of acetylsalicylic acid (ASA) for cardiovascular prevention associates with increased risk of gastrointestinal bleeding.	Aspirin	132-152	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-67
15297470-1	2004	Administration of selective and nonselective cyclooxygenase (COX)-2 inhibitors to rheumatoid arthritis patients taking low doses of acetylsalicylic acid (ASA) for cardiovascular prevention associates with increased risk of gastrointestinal bleeding.	Aspirin	154-157	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-67
15361550-2	2004	The present study investigated a possible relationship between the recently shown induction of cyclooxygenase (COX)-2 expression by the endocannabinoid analog R(+)methanandamide [R(+)-MA] and its effect on the viability of H4 human neuroglioma cells.	Endocannabinoids	136-151	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-117
15361550-2	2004	The present study investigated a possible relationship between the recently shown induction of cyclooxygenase (COX)-2 expression by the endocannabinoid analog R(+)methanandamide [R(+)-MA] and its effect on the viability of H4 human neuroglioma cells.	methanandamide	159-177	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-117
15361550-4	2004	Suppression of R(+)-MA-induced prostaglandin (PG) E2 synthesis with the selective COX-2 inhibitor celecoxib (0.01-1 microM) or inhibition of COX-2 expression by COX-2-silencing small-interfering RNA was accompanied by inhibition of R(+)-MA-mediated DNA fragmentation and cell death.	methanandamide	15-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
15361550-4	2004	Suppression of R(+)-MA-induced prostaglandin (PG) E2 synthesis with the selective COX-2 inhibitor celecoxib (0.01-1 microM) or inhibition of COX-2 expression by COX-2-silencing small-interfering RNA was accompanied by inhibition of R(+)-MA-mediated DNA fragmentation and cell death.	Celecoxib	98-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
15361550-6	2004	Cells were also protected from apoptotic cell death by other COX-2 inhibitors (NS-398 [[N-[2-(cyclohexyloxy)-4-nitrophenyl]-methanesulfonamide]] and diclofenac) and by the ceramide synthase inhibitor fumonisin B1, which interferes with COX-2 expression by R(+)-MA.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	79-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-66
15641602-0	2004	[The specific cox-2 inhibitor valdecoxib provides effective analgesia after inguinal hernia surgery].	valdecoxib	30-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
15666492-6	2004	We found that plaques from the irbesartan group had reduced inflammatory infiltration, less immunoreactivity for COX-2/mPGES-1 and MMPs, reduced gelatinolytic activity and increased collagen content.	Irbesartan	31-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-118
15666492-7	2004	It is worth noting that COX-2/mPGES-1 inhibition was observed after incubation in vitro with irbesartan but not with the selective AT2 blockade PD123,319.	Irbesartan	93-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
15730717-0	2004	[Proliferation inhibition effect of indomethacin on CML cells associated with down-regulation of phosphorylated STAT1/STAT5 and inhibition of COX-2 expression].	Indomethacin	36-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	142-147
15319438-6	2004	IkappaBalpha kinase inhibitor Bay 11-7082 or IkappaBalpha kinase dominant negative mutant significantly inhibited the induction of COX-2.	3-(4-methylphenylsulfonyl)-2-propenenitrile	30-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-136
15319438-7	2004	pp38 MAPK inhibitor SB203580 or eIF2alpha phosphorylation inhibitor 2-aminopurine attenuated the nuclear NF-kappaB DNA binding activity and COX-2 induction.	SB 203580	20-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-145
15319438-7	2004	pp38 MAPK inhibitor SB203580 or eIF2alpha phosphorylation inhibitor 2-aminopurine attenuated the nuclear NF-kappaB DNA binding activity and COX-2 induction.	2-Aminopurine	68-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-145
15544595-1	2004	BACKGROUND: Cyclooxygenase (COX)-2 is a key inducible enzyme that regulates the production of anti-inflammatory prostaglandin E(2).	Prostaglandins E	112-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-34
15544595-3	2004	We hypothesized that this polymorphism, which may result in decreased COX-2 transcription, could be associated with more severe asthma, and/or aspirin-intolerant asthma (AIA).	Aspirin	143-150	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-75
15570733-0	2004	The Vioxx withdrawal: latest in the COX-2 controversies.	rofecoxib	4-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-41
15570734-0	2004	A world without Vioxx: to COX-2 or not to COX-2?	rofecoxib	16-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-31
15570734-0	2004	A world without Vioxx: to COX-2 or not to COX-2?	rofecoxib	16-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47
15521001-2	2004	Previous in vitro studies have shown that etodolac is a selective inhibitor of cyclooxygenase (COX)-2 with selectivity in between that of other COX-2 inhibitors such as celecoxib and rofecoxib.	Etodolac	42-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	144-149
15521001-11	2004	CONCLUSIONS: Etodolac is a generic COX-2 selective inhibitor that reduces CSUGI events compared with the nonselective NSAID naproxen.	Etodolac	13-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40
15865061-1	2004	The selective inhibition of COX-2 isozymes should lead to a new generation of NSAIDs with significantly reduced side effects; e.g. celecoxib (Celebrex) and rofecoxib (Vioxx).	rofecoxib	156-165	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
15865061-1	2004	The selective inhibition of COX-2 isozymes should lead to a new generation of NSAIDs with significantly reduced side effects; e.g. celecoxib (Celebrex) and rofecoxib (Vioxx).	rofecoxib	167-172	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
15865061-3	2004	Although X-ray structures of COX-2 complexed with a small number of ligands are available, experimental data are missing for two well-known selective COX-2 inhibitors (rofecoxib and nimesulide) and docking results reported are controversial.	rofecoxib	168-177	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	150-155
15865061-3	2004	Although X-ray structures of COX-2 complexed with a small number of ligands are available, experimental data are missing for two well-known selective COX-2 inhibitors (rofecoxib and nimesulide) and docking results reported are controversial.	nimesulide	182-192	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	150-155
15548128-0	2004	Market withdrawal of Vioxx: is it time to rethink the use of COX-2 inhibitors?	rofecoxib	21-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-66
15477149-0	2004	Spectroscopic studies on Co(II) and Cu(II) complexes of 6-amino-1-methyl-5-nitrosouracil and its 6-methylamine derivative.	6-amino-1-methyl-5-nitrosouracil	56-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-31
15477149-0	2004	Spectroscopic studies on Co(II) and Cu(II) complexes of 6-amino-1-methyl-5-nitrosouracil and its 6-methylamine derivative.	6-methylamine	97-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-31
15477149-1	2004	Four complexes are obtained during the reactions of 6-amino-1-methyl-5-nitrosouracil and its 6-methylamine derivative with Co(II) and Cu(II) ions.	6-amino-1-methyl-5-nitrosouracil	52-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-129
15477149-1	2004	Four complexes are obtained during the reactions of 6-amino-1-methyl-5-nitrosouracil and its 6-methylamine derivative with Co(II) and Cu(II) ions.	6-methylamine	93-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-129
15475342-12	2004	CONCLUSIONS: Misoprostol, COX-2 specific and selective NSAIDs, and probably proton pump inhibitors significantly reduce the risk of symptomatic ulcers, and misoprostol and probably COX-2 specifics significantly reduce the risk of serious gastrointestinal complications, but data quality is low.	Misoprostol	156-167	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-31
15476716-0	2004	Metal-ion environment in solid Mn(II), Co(II) and Ni(II) hyaluronates.	Metals	0-5	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-45
15378772-1	2004	AIM: The protective effects of sodium butyrate and NSAIDs (especially the highly selective COX-2 inhibitors) have attracted considerable interest recently.	Butyric Acid	31-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-96
15378772-15	2004	NSAIDs could enhance the effects of sodium butyrate by down-regulating COX-2 expression.	Butyric Acid	36-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-76
15471453-0	2004	Synthesis of 4,5-diaryl-1H-pyrazole-3-ol derivatives as potential COX-2 inhibitors.	4,5-diaryl-1h-pyrazole-3-ol	13-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-71
15471453-1	2004	4,5-Diaryl-1H-pyrazole-3-ol was utilized as a versatile template to synthesize several classes of compounds such as pyrazolo-oxazines 7, pyrazolo-benzooxazines 9, pyrazolo-oxazoles 10, and its analogues 11a-c as potential COX-2 inhibitors.	4,5-diaryl-1h-pyrazole-3-ol	0-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	222-227
15453741-2	2004	The coupling reaction is effected by the use of a chiral sulfonamide-Cr complex (prepared in situ from 1d, CrBr3, Fe(III) or from Co(II), Et3N, and Mn), TMSCl, and 2,6-lutidine.	sulfonamide-cr	57-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	130-136
15446861-3	2004	Reaction of (R)-2 with the first two metal salts leads to complexes of the type [M((R)-4)(2)](ClO(4))(2) (M = Ni(II), Co(II)), where (R)-4 is a tridentate ligand resulting from the hydrolytic cleavage of one of the pyridyl groups from (R)-2.	clo	94-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-124
15473933-1	2004	BACKGROUND &amp; OBJECTIVE: Expression of cyclooxygenase-2 (COX-2)and matrix metalloproteinase-2 (MMP-2)increased in most tumor tissues.	Adenosine Monophosphate	12-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-65
15473933-4	2004	METHODS: SP immunohistochemistry was used to determine the expression of COX-2 and MMP-2 in 42 patients with lung cancer.	TFF2 protein, human	9-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-78
15155531-10	2004	Quercetin and the synthetic COX-2 inhibitors (10 microM) suppressed PGE2 production by approximately 70% after 24 h exposure (P &lt; 0.001).	Dinoprostone	68-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
15475461-2	2004	The purpose of this study was to investigate the expression of 5-Lox in EAC of a rat model and in human samples as well as the chemopreventive effects of zileuton (a specific 5-Lox inhibitor) and celecoxib (a specific Cox2 inhibitor) in the rat EAC model.	Celecoxib	196-205	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	218-222
15479233-2	2004	Conversely, whereas dexamethasone and budesonide were highly effective inhibitors of interleukin-1beta-induced cyclooxygenase (COX)/prostaglandin E synthase (PGES) activity and COX-2 expression, RU486 (&lt;1 microm) was a poor inhibitor, but was able to efficiently antagonize the effects of dexamethasone and budesonide.	Dexamethasone	20-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	177-182
15479233-2	2004	Conversely, whereas dexamethasone and budesonide were highly effective inhibitors of interleukin-1beta-induced cyclooxygenase (COX)/prostaglandin E synthase (PGES) activity and COX-2 expression, RU486 (&lt;1 microm) was a poor inhibitor, but was able to efficiently antagonize the effects of dexamethasone and budesonide.	Budesonide	38-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	177-182
15782440-0	2004	Quantitative structure activity relationship studies of diaryl furanones as selective COX-2 inhibitors.	diaryl furanones	56-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-91
15782440-2	2004	QSAR studies have been performed on a series of diaryl furanones that acts as selective COX-2 inhibitor using Molecular Operating Environment (MOE).	diaryl furanones	48-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-93
15485309-5	2004	Celecoxib (Celebrex), Pfizer), a selective COX-2 inhibitor and potent anti-inflammatory agent, has been approved for the treatment of osteoarthritis and rheumatoid arthritis.	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
15485309-5	2004	Celecoxib (Celebrex), Pfizer), a selective COX-2 inhibitor and potent anti-inflammatory agent, has been approved for the treatment of osteoarthritis and rheumatoid arthritis.	Celecoxib	11-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
15485309-7	2004	Phase II clinical trials suggest that COX-2 inhibition by celecoxib would enhance response to cytotoxic chemotherapy or radiation therapy through interference with cellular proliferation and tumor angiogenic processes, promotion of apoptosis and immune surveillance, or other possible mechanisms.	Celecoxib	58-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-43
15485309-8	2004	Celecoxib has shown promising antitumor efficacy in lung cancer and a large variety of solid tumors that rely on COX-2-related mechanisms for growth and survival.	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-118
15480320-0	2004	Dynamics of COX-2 in nasal mucosa and nasal polyps from aspirin-tolerant and aspirin-intolerant patients with asthma.	Aspirin	56-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-17
15480320-0	2004	Dynamics of COX-2 in nasal mucosa and nasal polyps from aspirin-tolerant and aspirin-intolerant patients with asthma.	Aspirin	77-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-17
15560116-9	2004	In this study, we noted that 9cRA increased the production of PGE2 and TXA2 by the induction of COX-2 and PGE synthase in the presence of LPS.	Alitretinoin	29-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-101
15560116-9	2004	In this study, we noted that 9cRA increased the production of PGE2 and TXA2 by the induction of COX-2 and PGE synthase in the presence of LPS.	Dinoprostone	62-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-101
15623076-1	2004	Rofecoxib (Vioxx), the first COX-2 selective non-steroidal anti-inflammatory drug (NSAID), was recently withdrawn by Merck Sharp &amp; Dohme.	rofecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34
15623076-1	2004	Rofecoxib (Vioxx), the first COX-2 selective non-steroidal anti-inflammatory drug (NSAID), was recently withdrawn by Merck Sharp &amp; Dohme.	rofecoxib	11-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34
15623076-6	2004	Finally, in patients with high cardiovascular risk who should receive a COX-2 selective NSAID, the association with a low dose of acetylsalicylic acid is recommended in order to benefit of a protective antiplatelet effect.	Aspirin	130-150	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
15326524-0	2004	2-hydroxymethyl-4-[5-(4-methoxyphenyl)-3-trifluoromethyl-1H-1-pyrazolyl]-1-benzenesulfonamide (DRF-4367): an orally active COX-2 inhibitor identified through pharmacophoric modulation.	2-hydroxymethyl-4-(5-(4-methoxyphenyl)-3-trifluoromethyl-1H-1-pyrazolyl)-1-benzenesulfonamide	0-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-128
15326524-0	2004	2-hydroxymethyl-4-[5-(4-methoxyphenyl)-3-trifluoromethyl-1H-1-pyrazolyl]-1-benzenesulfonamide (DRF-4367): an orally active COX-2 inhibitor identified through pharmacophoric modulation.	2-hydroxymethyl-4-(5-(4-methoxyphenyl)-3-trifluoromethyl-1H-1-pyrazolyl)-1-benzenesulfonamide	95-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-128
15326524-1	2004	Analogs of 1,5-diarylpyrazoles with a novel pharmacophore at N1 were designed, synthesized and evaluated for the in-vitro cyclooxygenase (COX-1/COX-2) inhibitory activity.	1,5-diarylpyrazoles	11-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	144-149
15514750-0	2004	Synthesis and magnetism of oxygen-bridged tetranuclear defect dicubane Co(II) and Ni(II) clusters.	Oxygen	27-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-77
15561649-2	2004	The COX-2SIs rofecoxib and celecoxib have been shown to be as effective as traditional NSAADs for pain relief, but with an improved GI safety profile.	rofecoxib	13-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
15243734-2	2004	The procedure exploits the enhancement of the cobalt peak obtained by use of the system Co(II)-dimethylglyoxime-piperazine-1,4-bis(2-ethanesulfonic acid)-cetyltrimethylammonium bromide.	Cobalt	46-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-93
15243734-2	2004	The procedure exploits the enhancement of the cobalt peak obtained by use of the system Co(II)-dimethylglyoxime-piperazine-1,4-bis(2-ethanesulfonic acid)-cetyltrimethylammonium bromide.	Cetrimonium	154-184	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-93
15517885-4	2004	Resveratrol has been shown to suppress the activation of several transcription factors, including NF-kappaB, AP-1 and Egr-1; to inhibit protein kinases including IkappaBalpha kinase, JNK, MAPK, Akt, PKC, PKD and casein kinase II; and to down-regulate products of genes such as COX-2, 5-LOX, VEGF, IL-1, IL-6, IL-8, AR and PSA.	Resveratrol	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	277-282
15574518-7	2005	Using an in vitro editing assay we find that the 3" UTR of COII, indeed, functions as a guide for both the site and number of uridines added to the coding region of the COII mRNA.	Uridine	126-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	169-173
15377836-1	2004	Alpha-TEA, a nonhydrolyzable ether analog of vitamin E (RRR-alpha-tocopherol), and celecoxib, a specific COX-2 inhibitor, were delivered separately or in combination to investigate their anticancer properties, using MDA-MB-435-FL-GFP human breast cancer xenografts in nude mice.	Celecoxib	83-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-110
15073046-7	2004	Curcumin (20 micro M) significantly inhibited LPS-induced COX-2 expression; this effect, rather than the catalytic inhibition of COX, may contribute to the decreased PGE(2) formation.	Curcumin	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
15073046-8	2004	Without LPS-stimulation, however, curcumin increased the COX-2 level in the macrophage cells.	Curcumin	34-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-62
15073046-9	2004	Studies with isolated ovine COX-1 and COX-2 enzymes showed that the curcuminoids had significantly higher inhibitory effects on the peroxidase activity of COX-1 than that of COX-2.	curcuminoids	68-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-43
15073046-9	2004	Studies with isolated ovine COX-1 and COX-2 enzymes showed that the curcuminoids had significantly higher inhibitory effects on the peroxidase activity of COX-1 than that of COX-2.	curcuminoids	68-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	174-179
15073046-11	2004	The results suggest that curcumin affects arachidonic acid metabolism by blocking the phosphorylation of cPLA(2), decreasing the expression of COX-2 and inhibiting the catalytic activities of 5-LOX.	Curcumin	25-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	143-148
15073046-11	2004	The results suggest that curcumin affects arachidonic acid metabolism by blocking the phosphorylation of cPLA(2), decreasing the expression of COX-2 and inhibiting the catalytic activities of 5-LOX.	Arachidonic Acid	42-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	143-148
15254428-5	2004	COX-2 was detected in three cell lines, which produced PGE2 (two from metastases).	Dinoprostone	55-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
15254428-14	2004	Our findings provide new informations about individual eicosanoids produced by HNSCC cells and their differential regulation by the selective COX-2 inhibitor celecoxib.	Eicosanoids	55-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	142-147
15254428-14	2004	Our findings provide new informations about individual eicosanoids produced by HNSCC cells and their differential regulation by the selective COX-2 inhibitor celecoxib.	Celecoxib	158-167	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	142-147
15355919-3	2004	EXPERIMENTAL DESIGN: COX-2 expression in normal colonic mucosa (n = 50), hyperplastic polyps (n = 43), sporadic adenomas (n = 67), and invasive colonic adenocarcinoma (n = 39) was studied in formalin-fixed and paraffin-embedded tissue sections from endoscopy biopsy and colonic resection specimens.	Formaldehyde	191-199	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-26
15355919-3	2004	EXPERIMENTAL DESIGN: COX-2 expression in normal colonic mucosa (n = 50), hyperplastic polyps (n = 43), sporadic adenomas (n = 67), and invasive colonic adenocarcinoma (n = 39) was studied in formalin-fixed and paraffin-embedded tissue sections from endoscopy biopsy and colonic resection specimens.	Paraffin	210-218	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-26
15355919-4	2004	Immunohistochemistry (avidin-biotin complex technique with double immunolabeling) was used to identify the phenotypes of COX-2-producing cells.	avidin-biotin	22-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-126
24672093-3	2004	OBJECTIVE: The aim of this study was to compare the efficacy and tolerabilityof the COX-2 inhibitor parecoxib sodium and the NSAID diclofenac sodium as preemptive analgesics in patients undergoing elective general surgery.	parecoxib	100-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-89
24672093-18	2004	CONCLUSIONS: In this study of patients undergoing elective general surgery,patients treated with the COX-2 specific inhibitor parecoxib experienced no pain at 12 hours, and the treatment was well tolerated.	parecoxib	126-135	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-106
15278327-1	2004	AIMS: A post-marketing surveillance study using the technique of Prescription Event Monitoring was undertaken to monitor the safety of celecoxib, a cyclo-oxygenase (COX)-2 inhibitor, as prescribed in primary care in England.	Celecoxib	135-144	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	148-171
15335302-6	2004	New evidence suggests that selective COX-2 inhibitors may be tolerated in patients with aspirin-sensitive urticaria.	Aspirin	88-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-42
15337291-4	2004	Some of them, more soluble in water, were tested to define the influence on prostaglandin biosynthesis via inhibition of cyclooxygenases (COX1 and COX2) by a chemiluminescent method suitable for fast screening.	Prostaglandins	76-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-151
15289892-0	2004	A combination of selective COX-2 inhibitors and hydrogen peroxide increase the reactive oxygen species formation in osteosarcoma cells after X-ray irradiation.	Reactive Oxygen Species	79-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-32
15446566-7	2004	Thalidomide decreased the stability of TNF-mRNA and COX-2 mRNA.	Thalidomide	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-57
15205395-2	2004	In the early 1990s, the pre-ovulatory rise in follicular prostaglandin synthesis was shown to result from the selective induction of a novel COX isoform, now referred to as COX-2.	Prostaglandins	57-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	173-178
15289885-5	2004	The Cox-2 protein was strongly induced 2 h after exposure to n-LDL or Ox-LDL, the induction was maximal after 4 h and sustained for at least 8 h. The effect was specific for Cox-2, as Cox-1 expression was not modulated either by n-LDL or by Ox-LDL.	Nitrogen	16-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
15289885-5	2004	The Cox-2 protein was strongly induced 2 h after exposure to n-LDL or Ox-LDL, the induction was maximal after 4 h and sustained for at least 8 h. The effect was specific for Cox-2, as Cox-1 expression was not modulated either by n-LDL or by Ox-LDL.	Nitrogen	16-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	174-179
15289885-8	2004	N-LDL and Ox-LDL increased PGE2 release in a Cox-2-dependent manner while TXA2 and PGI2 release were not affected either by n-LDL or Ox-LDL.	Dinoprostone	27-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-50
15289885-9	2004	The finding that n-LDL and Ox-LDL induces Cox-2 in human endothelial cells through a p38 MAPK, NF-kappaB, CREB dependent pathway thus modulating PGE2 release, suggests a new mechanism by which these lipoproteins induce endothelial dysfunction, sustaining inflammatory processes in the arterial wall.	Nitrogen	6-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47
15289885-9	2004	The finding that n-LDL and Ox-LDL induces Cox-2 in human endothelial cells through a p38 MAPK, NF-kappaB, CREB dependent pathway thus modulating PGE2 release, suggests a new mechanism by which these lipoproteins induce endothelial dysfunction, sustaining inflammatory processes in the arterial wall.	Dinoprostone	145-149	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47
15461861-1	2004	Cyclooxygenase (COX), the key enzyme in prostaglandin cascade, is expressed in two isoforms: the constitutive COX-1 and the inducible COX-2.	Prostaglandins	40-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-139
15289892-3	2004	A low dose concentration of COX-2 inhibitor in combination with hydrogen peroxide and irradiation did affect ROS formation in the intracellular compartment; however, this same combination of agents at high doses did not modulate the effect of irradiation.	Reactive Oxygen Species	109-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
15254968-1	2004	Cyclooxygenase (COX)-2 is generally known as an inducible enzyme, and it produces arachidonic acid to prostaglandin E2 (PGE2), which modulates bone metabolism.	Arachidonic Acid	82-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-22
15254968-9	2004	These data indicate that PGE2 produced by COX-2 increases BMP-2 expression via binding the EP4 receptor.	Dinoprostone	25-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47
15276032-0	2004	Adsorption of Co(II), Ni(II), Cu(II), and Zn(II) on hexagonal templated zirconia obtained thorough a sol-gel process: the effects of nanostructure on adsorption features.	zirconium oxide	72-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-20
15276032-3	2004	The adsorption affinity of the synthesized hexagonal templated zirconia toward the cations is Cu(II)&gt;Zn(II) &gt;&gt;Ni(II)&gt;Co(II).	zirconium oxide	63-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-135
15276032-3	2004	The adsorption affinity of the synthesized hexagonal templated zirconia toward the cations is Cu(II)&gt;Zn(II) &gt;&gt;Ni(II)&gt;Co(II).	cu(ii)	94-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-135
15276032-3	2004	The adsorption affinity of the synthesized hexagonal templated zirconia toward the cations is Cu(II)&gt;Zn(II) &gt;&gt;Ni(II)&gt;Co(II).	Zinc	104-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-135
15331705-7	2004	Indomethacin (inhibiting both COX-1 and COX-2) and specific COX-1 and COX-2 inhibitors reduced rotavirus infection by 85 and 50%, respectively, as measured by an IFA.	Indomethacin	0-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
15386801-5	2004	In addition to Co(II), other transition metal ions were also tested, and the results showed that the proposed system was highly selective for Co(II).	Metals	40-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	142-148
15330628-1	2004	In this work, a new method for highly efficient and selective oxidative deprotection of a variety of structurally diverse trimethylsilyl (TMS) and tert-butyldimethylsilyl (TBS) ethers using molecular oxygen in the presence of N-hydroxyphthalimide (NHPI) and various types of Co(II) complexes is reported.	N-hydroxyphthalimide	226-246	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	275-281
15330628-1	2004	In this work, a new method for highly efficient and selective oxidative deprotection of a variety of structurally diverse trimethylsilyl (TMS) and tert-butyldimethylsilyl (TBS) ethers using molecular oxygen in the presence of N-hydroxyphthalimide (NHPI) and various types of Co(II) complexes is reported.	N-hydroxyphthalimide	248-252	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	275-281
15266333-9	2004	In addition, 15d-PGJ(2) suppressed tumour necrosis factor-alpha-induced-COX-2 expression, confirming the reciprocal correlation between COX-2 and PPARgamma.	15d-pgj	13-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
15266333-9	2004	In addition, 15d-PGJ(2) suppressed tumour necrosis factor-alpha-induced-COX-2 expression, confirming the reciprocal correlation between COX-2 and PPARgamma.	15d-pgj	13-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	136-141
15285646-0	2004	Comparison of cysteine and penicillamine ligands in a Co(II) maquette.	Cysteine	14-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-60
15285646-0	2004	Comparison of cysteine and penicillamine ligands in a Co(II) maquette.	Penicillamine	27-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-60
15285646-1	2004	l-Penicillamine (Pen) has been investigated as a ligand for metalloprotein design by examining the binding of Co(II) to the sequence NH(2)-KL(Pen)EGG.(Pen)IG(Pen)GA(Pen).GGW-CONH(2).	L-Penicillamine	0-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-116
15285646-2	2004	For comparison, we have studied Co(II) binding to the analogous sequence with Cys ligands, the ferredoxin maquette ligand IGA that was originally designed to bind a [4Fe-4S] cluster.	Cysteine	78-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-38
15285646-3	2004	The Co(II) affinity and UV-vis spectroscopic properties of IGA indicate formation of a pseudotetrahedral tetrathiolate ligated Co(II).	pseudotetrahedral tetrathiolate	87-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
15285646-3	2004	The Co(II) affinity and UV-vis spectroscopic properties of IGA indicate formation of a pseudotetrahedral tetrathiolate ligated Co(II).	pseudotetrahedral tetrathiolate	87-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
15285646-4	2004	In contrast, IGA-Pen showed formation of a pseudotetrahedral complex with Co(II) bound by three Pen ligands and an exogenous H(2)O.	h(2)	125-129	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-80
15293263-2	2004	Several statistically significant QSAR models were developed and suggest that hydrophobicity of entire molecules and a fluorine atom substitution at position 8 of the non benzene sulphonyl ring fused with central pyrazole core of series 1 compounds is crucial for improved COX-2 selectivity.	Fluorine	119-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	273-278
15293263-2	2004	Several statistically significant QSAR models were developed and suggest that hydrophobicity of entire molecules and a fluorine atom substitution at position 8 of the non benzene sulphonyl ring fused with central pyrazole core of series 1 compounds is crucial for improved COX-2 selectivity.	Benzene	171-178	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	273-278
15293263-2	2004	Several statistically significant QSAR models were developed and suggest that hydrophobicity of entire molecules and a fluorine atom substitution at position 8 of the non benzene sulphonyl ring fused with central pyrazole core of series 1 compounds is crucial for improved COX-2 selectivity.	pyrazole	213-221	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	273-278
15242810-4	2004	The augmented COX-2 production was transcriptionally suppressed by nobiletin.	nobiletin	67-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
15242810-8	2004	Therefore, these results suggest that nobiletin inhibits the UVB-induced production of PGE2 not only by suppressing the expression of COX-2 but also by decreasing the activity of cPLA2 in human keratinocytes.	nobiletin	38-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-139
15242810-8	2004	Therefore, these results suggest that nobiletin inhibits the UVB-induced production of PGE2 not only by suppressing the expression of COX-2 but also by decreasing the activity of cPLA2 in human keratinocytes.	Dinoprostone	87-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-139
15327557-3	2004	OBJECTIVE: To confirm that COX-2 could be a molecular target in adjunctive therapy to ALA-based PDT, we investigated (i) COX-2 expression in various skin and oral diseases, and (ii) the inhibitory effects on cellular growth of COX-2 selective inhibitor (nimesulide), ALA-based PDT and their combination on human oral squamous cell carcinoma (SCC) cell lines.	Aminolevulinic Acid	86-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-32
15327557-3	2004	OBJECTIVE: To confirm that COX-2 could be a molecular target in adjunctive therapy to ALA-based PDT, we investigated (i) COX-2 expression in various skin and oral diseases, and (ii) the inhibitory effects on cellular growth of COX-2 selective inhibitor (nimesulide), ALA-based PDT and their combination on human oral squamous cell carcinoma (SCC) cell lines.	nimesulide	254-264	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-32
15327557-3	2004	OBJECTIVE: To confirm that COX-2 could be a molecular target in adjunctive therapy to ALA-based PDT, we investigated (i) COX-2 expression in various skin and oral diseases, and (ii) the inhibitory effects on cellular growth of COX-2 selective inhibitor (nimesulide), ALA-based PDT and their combination on human oral squamous cell carcinoma (SCC) cell lines.	Aminolevulinic Acid	267-270	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-32
15327557-10	2004	Nimesulide had an inhibitory effect in vitro on HSC-2 (proven to be a COX-2 high expresser), but not on HSC-4 (a COX-2 non-expresser).	nimesulide	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-75
15276032-3	2004	The adsorption affinity of the synthesized hexagonal templated zirconia toward the cations is Cu(II)&gt;Zn(II) &gt;&gt;Ni(II)&gt;Co(II).	Nickel(2+)	119-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-135
15322227-0	2004	COX-2 Regulates the insulin-like growth factor I-induced potentiation of Zn(2+)-toxicity in primary cortical culture.	Zinc	73-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
15322227-7	2004	Moreover, enhanced COX-2 activity led to a decrease in the cell"s reducing power, as indicated by a gradual depletion of intracellular GSH.	Glutathione	135-138	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-24
15322227-10	2004	These results suggest that COX-2 is an endogenous factor responsible for the IGF-I-induced potentiation of Zn(2+) toxicity and that enhanced COX-2 activity leads to a decrease in the cell"s reducing power and an increase in ROS accumulation in primary cortical cultures.	Zinc	107-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-32
15322227-10	2004	These results suggest that COX-2 is an endogenous factor responsible for the IGF-I-induced potentiation of Zn(2+) toxicity and that enhanced COX-2 activity leads to a decrease in the cell"s reducing power and an increase in ROS accumulation in primary cortical cultures.	Reactive Oxygen Species	224-227	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	141-146
16120427-24	2004	Inhibition of complex I with rotenone increases the expression and synthesis of Bcl-2 and Cox-2, both effects are similar effects to produced by IL-1 in human chondrocytes.	Rotenone	29-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-95
15328060-1	2004	In the present review article, we present the efforts done so far for elucidating the mechanism of adsorption of the Co(II) species, mainly Co(H(2)O)(6)(2+), on the interfacial region developed between metal oxide particles, used as catalytic supports, and aqueous electrolytic solutions.	co(h(2)o	140-148	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-123
15328060-1	2004	In the present review article, we present the efforts done so far for elucidating the mechanism of adsorption of the Co(II) species, mainly Co(H(2)O)(6)(2+), on the interfacial region developed between metal oxide particles, used as catalytic supports, and aqueous electrolytic solutions.	metal oxide	202-213	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-123
15328060-4	2004	It seems that, generally, the mechanism changes progressively along the Co(II) surface concentration from the deposition of monodentate-mononuclear inner sphere complexes, weakly evidenced in too low values of the Co(II) surface concentration, to multidentate, multinuclear inner sphere surface complexes at relatively low Co(II) surface concentrations, and then into surface Co(OH)(2)-like, eventually mixed precipitates, at relatively high Co(II) surface concentrations but at pH values lower than those required for bulk precipitation.	Carbonic Acid	376-385	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-78
15328060-7	2004	Thus, SiO(2) favors the formation of the Co(OH)(2)-like precipitates even at relatively low Co(II) surface concentrations.	Silicon Dioxide	6-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-98
15328060-7	2004	Thus, SiO(2) favors the formation of the Co(OH)(2)-like precipitates even at relatively low Co(II) surface concentrations.	Carbonic Acid	41-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-98
15328060-10	2004	The exact local structure of the inner sphere Co(II) surface complexes, formed by exchanging the H(2)O ligands with surface oxygens, has been already approached but only for the surface planes of the alpha-Al(2)O(3) and rutile monocrystals.	Water	97-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-52
15328060-10	2004	The exact local structure of the inner sphere Co(II) surface complexes, formed by exchanging the H(2)O ligands with surface oxygens, has been already approached but only for the surface planes of the alpha-Al(2)O(3) and rutile monocrystals.	Oxygen	124-131	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-52
15330628-0	2004	Novel method for efficient aerobic oxidation of silyl ethers to carbonyl compounds catalyzed with N-hydroxyphthalimide (NHPI) and lipophilic Co(II) complexes.	silyl ethers	48-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	141-147
15330628-1	2004	In this work, a new method for highly efficient and selective oxidative deprotection of a variety of structurally diverse trimethylsilyl (TMS) and tert-butyldimethylsilyl (TBS) ethers using molecular oxygen in the presence of N-hydroxyphthalimide (NHPI) and various types of Co(II) complexes is reported.	Trimethylsilyl radical	122-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	275-281
15330628-1	2004	In this work, a new method for highly efficient and selective oxidative deprotection of a variety of structurally diverse trimethylsilyl (TMS) and tert-butyldimethylsilyl (TBS) ethers using molecular oxygen in the presence of N-hydroxyphthalimide (NHPI) and various types of Co(II) complexes is reported.	tms	138-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	275-281
15330628-1	2004	In this work, a new method for highly efficient and selective oxidative deprotection of a variety of structurally diverse trimethylsilyl (TMS) and tert-butyldimethylsilyl (TBS) ethers using molecular oxygen in the presence of N-hydroxyphthalimide (NHPI) and various types of Co(II) complexes is reported.	tert-butyldimethylsilyl (tbs) ethers	147-183	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	275-281
15330628-1	2004	In this work, a new method for highly efficient and selective oxidative deprotection of a variety of structurally diverse trimethylsilyl (TMS) and tert-butyldimethylsilyl (TBS) ethers using molecular oxygen in the presence of N-hydroxyphthalimide (NHPI) and various types of Co(II) complexes is reported.	Oxygen	200-206	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	275-281
15084473-9	2004	Together, these data suggest that COX-2-dependent PG synthesis is required during early stages of muscle regeneration and thus raise caution about the use of COX-2-selective inhibitors in patients with muscle injury or disease.	Prostaglandins	50-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-39
15289320-2	2004	Here we show that phorbol ester-mediated induction of VEGF and COX-2 expression in colon carcinoma cells is inhibited by 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)).	Phorbol Esters	18-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-68
15289320-2	2004	Here we show that phorbol ester-mediated induction of VEGF and COX-2 expression in colon carcinoma cells is inhibited by 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)).	15-deoxy-delta	121-135	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-68
15289320-2	2004	Here we show that phorbol ester-mediated induction of VEGF and COX-2 expression in colon carcinoma cells is inhibited by 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)).	prostaglandin j	143-158	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-68
15289320-2	2004	Here we show that phorbol ester-mediated induction of VEGF and COX-2 expression in colon carcinoma cells is inhibited by 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)).	2-(ETHOXYMETHYL)-4-(4-FLUOROPHENYL)-3-[2-(2-HYDROXYPHENOXY)PYRIMIDIN-4-YL]ISOXAZOL-5(2H)-ONE	167-170	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-68
15289320-3	2004	This cyclopentenone was able to inhibit activator protein1 (AP-1)-dependent transcriptional induction of COX-2 and VEGF promoters induced by phorbol 12-myristate 13-acetate (PMA) or c-Jun overexpression.	cyclopentenone	5-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-110
15289320-3	2004	This cyclopentenone was able to inhibit activator protein1 (AP-1)-dependent transcriptional induction of COX-2 and VEGF promoters induced by phorbol 12-myristate 13-acetate (PMA) or c-Jun overexpression.	Tetradecanoylphorbol Acetate	141-172	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-110
15289320-3	2004	This cyclopentenone was able to inhibit activator protein1 (AP-1)-dependent transcriptional induction of COX-2 and VEGF promoters induced by phorbol 12-myristate 13-acetate (PMA) or c-Jun overexpression.	Tetradecanoylphorbol Acetate	174-177	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-110
15598423-3	2004	In the present study, we have investigated the effects of thalidomide, CC-5013 and CC-4047 on the expression of COX-2 by stimulated PBMC.	Thalidomide	58-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-117
15598423-4	2004	Our results show that thalidomide and IMiDs inhibited the expression of COX-2 but not the COX-1 protein in LPS-TNF-alpha and IL-1beta stimulated PBMC and shortened the half-life of COX-2 mRNA in a dose-dependent manner.	Thalidomide	22-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
15598423-4	2004	Our results show that thalidomide and IMiDs inhibited the expression of COX-2 but not the COX-1 protein in LPS-TNF-alpha and IL-1beta stimulated PBMC and shortened the half-life of COX-2 mRNA in a dose-dependent manner.	Thalidomide	22-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	181-186
15270659-4	2004	Cyclooxygenase (COX)-2, an enzyme involved in prostaglandin production in pathologic states, is often overexpressed in premalignant and malignant lesions.	Prostaglandins	46-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-22
15242723-3	2004	Partial inhibitors of both COX-1 and COX-2, such as nimesulide and meloxicam, also cross-react but only at high drug doses.	nimesulide	52-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-42
15242723-3	2004	Partial inhibitors of both COX-1 and COX-2, such as nimesulide and meloxicam, also cross-react but only at high drug doses.	Meloxicam	67-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-42
15309017-6	2004	Emerging evidence shows that airway remodeling may also be a result of the autocrine action of secreted inflammatory mediators, including T(H)2 cytokines, growth factors, and COX-2-dependent prostanoids.	Prostaglandins	191-202	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	175-180
15265936-0	2004	Cyclooxygenase (COX)-2 inhibitor celecoxib abrogates TNF-induced NF-kappa B activation through inhibition of activation of I kappa B alpha kinase and Akt in human non-small cell lung carcinoma: correlation with suppression of COX-2 synthesis.	Celecoxib	33-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-22
15246187-1	2004	Cyclooxygenase (Cox)-2 plays an important role in cell proliferation, carcinogenesis and tumor growth, in part through the synthesis of prostaglandin E2 (PGE2) as well as through other yet unknown routes.	Dinoprostone	136-152	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-22
15246187-1	2004	Cyclooxygenase (Cox)-2 plays an important role in cell proliferation, carcinogenesis and tumor growth, in part through the synthesis of prostaglandin E2 (PGE2) as well as through other yet unknown routes.	Dinoprostone	154-158	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-22
15279595-1	2004	Valdecoxib, parecoxib, etoricoxib and lumiracoxib represent the second generation of selective COX-2 inhibitors.	valdecoxib	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-100
15279595-1	2004	Valdecoxib, parecoxib, etoricoxib and lumiracoxib represent the second generation of selective COX-2 inhibitors.	parecoxib	12-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-100
15279595-1	2004	Valdecoxib, parecoxib, etoricoxib and lumiracoxib represent the second generation of selective COX-2 inhibitors.	Etoricoxib	23-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-100
15279595-1	2004	Valdecoxib, parecoxib, etoricoxib and lumiracoxib represent the second generation of selective COX-2 inhibitors.	lumiracoxib	38-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-100
15279596-2	2004	A recently developed class of pharmacological agents incorporating primary sulfamoyl moieties in their molecule is constituted by the COX-2 selective inhibitors, with at least two clinically used drugs, celecoxib and valdecoxib.	Celecoxib	203-212	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-139
15279596-2	2004	A recently developed class of pharmacological agents incorporating primary sulfamoyl moieties in their molecule is constituted by the COX-2 selective inhibitors, with at least two clinically used drugs, celecoxib and valdecoxib.	valdecoxib	217-227	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-139
15279596-4	2004	It was recently shown that the sulfonamide COX-2 selective inhibitors (but not the methylsulfone ones) also act as nanomolar inhibitors of several isozymes of the metallo-enzyme carbonic anhydrase (CA), some of which are strongly involved in tumourigenesis.	Sulfonamides	31-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
15262246-1	2004	OBJECTIVES: To investigate the relative contribution of the cyclooxygenase (COX) isoenzymes COX-1 and COX-2 to prostaglandin E2 (PGE2) release from inflamed synovial tissue in N=10 patients with primary osteoarthritis (OA) in vitro and to determine possible effects of COX inhibitors on the gene expression of synovial COX-1 and COX-2.	Dinoprostone	111-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-107
15262246-1	2004	OBJECTIVES: To investigate the relative contribution of the cyclooxygenase (COX) isoenzymes COX-1 and COX-2 to prostaglandin E2 (PGE2) release from inflamed synovial tissue in N=10 patients with primary osteoarthritis (OA) in vitro and to determine possible effects of COX inhibitors on the gene expression of synovial COX-1 and COX-2.	Dinoprostone	129-133	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-107
15262246-9	2004	In contrast to synovial COX-1, RT-PCR revealed a significant induction of COX-2 through PGE2.	Dinoprostone	88-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
15249033-0	2004	Spectroscopic studies on Mn(II), Co(II), Ni(II), and Cu(II) complexes with N-donor tetradentate (N4) macrocyclic ligand derived from ethylcinnamate moiety.	ethyl cinnamate	133-147	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-39
15249033-3	2004	The molar conductance measurements of the complexes in DMSO correspond to be nonelectrolyte nature for Mn(II), Co(II), and Cu(II) whereas 1:2 electrolytes for Ni(II) complexes.	Dimethyl Sulfoxide	55-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	111-116
15249033-5	2004	On the basis of IR, electronic, and EPR spectral studies an octahedral geometry has been assigned for Mn(II) and Co(II) complexes, square-planar for Ni(II) whereas tetragonal for Cu(II) complexes.	Nickel(2+)	149-155	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-119
15249033-5	2004	On the basis of IR, electronic, and EPR spectral studies an octahedral geometry has been assigned for Mn(II) and Co(II) complexes, square-planar for Ni(II) whereas tetragonal for Cu(II) complexes.	cu(ii)	179-185	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-119
15240129-3	2004	In this study, we examined in human colon cancer cells the effect of indomethacin and NS-398 (a pre-clinical selective COX-2 inhibitor) on expression of 96 genes of the EGF/PDGF signaling pathways essential for cell proliferation, migration, and survival.	Indomethacin	69-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-124
15240129-3	2004	In this study, we examined in human colon cancer cells the effect of indomethacin and NS-398 (a pre-clinical selective COX-2 inhibitor) on expression of 96 genes of the EGF/PDGF signaling pathways essential for cell proliferation, migration, and survival.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	86-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-124
15194006-0	2004	Effects of the selective COX-2 inhibitors celecoxib and rofecoxib on human vascular cells.	Celecoxib	42-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-30
15194006-0	2004	Effects of the selective COX-2 inhibitors celecoxib and rofecoxib on human vascular cells.	rofecoxib	56-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-30
15256475-0	2004	Cyclooxygenase (COX)-2 inhibitor celecoxib abrogates activation of cigarette smoke-induced nuclear factor (NF)-kappaB by suppressing activation of IkappaBalpha kinase in human non-small cell lung carcinoma: correlation with suppression of cyclin D1, COX-2, and matrix metalloproteinase-9.	Celecoxib	33-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-22
15256475-0	2004	Cyclooxygenase (COX)-2 inhibitor celecoxib abrogates activation of cigarette smoke-induced nuclear factor (NF)-kappaB by suppressing activation of IkappaBalpha kinase in human non-small cell lung carcinoma: correlation with suppression of cyclin D1, COX-2, and matrix metalloproteinase-9.	Celecoxib	33-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	250-255
15256475-2	2004	CS-associated malignancies including cancers of the larynx, oral cavity, and pharynx, esophagus, pancreas, kidney, bladder, and lung; all are known to overexpress the nuclear factor-kappaB (NF-kappaB)-regulated gene products cyclin D1, cyclooxygenase (COX)-2, and matrix metalloprotease-9.	Cesium	0-2	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	236-258
15256475-3	2004	Whether the COX-2 inhibitor, celecoxib, approved for the treatment of colon carcinogenesis and rheumatoid arthritis, affects CS-induced NF-kappaB activation is not known, although the role of NF-kappaB in regulation of apoptosis, angiogenesis, carcinogenesis, and inflammation is established.	Celecoxib	29-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-17
15256475-3	2004	Whether the COX-2 inhibitor, celecoxib, approved for the treatment of colon carcinogenesis and rheumatoid arthritis, affects CS-induced NF-kappaB activation is not known, although the role of NF-kappaB in regulation of apoptosis, angiogenesis, carcinogenesis, and inflammation is established.	Cesium	125-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-17
15269139-7	2004	COX-2 inhibitors and, in part, COX-1 inhibitor blocked ET-1-induced PGE(2) and vascular endothelial growth factor release, indicating that both enzymes participate in PGE(2) production to a different extent.	Prostaglandins E	167-170	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
15236564-6	2004	In the same vein, rate constants for reduction of Co(III) centers to Co(II) were an order of magnitude slower than those for other metal center or phthalocyanine ring reductions because of Franck-Condon restrictions.	Metals	131-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-75
15252592-0	2004	Synergistic effect of Ni(II) and Co(II) ions on the sulfite induced autoxidation of Cu(II)/tetraglycine complex.	cu(ii)	84-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-39
15252592-0	2004	Synergistic effect of Ni(II) and Co(II) ions on the sulfite induced autoxidation of Cu(II)/tetraglycine complex.	glycyl-glycyl-glycyl-glycine	91-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-39
15184060-4	2004	NAA also decreased the levels of COX-2 protein and activated NF-kappaB in IL-1beta-stimulated STTG cells but had little effect on unstimulated cells.	N-acetylaspartate	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-38
15151910-3	2004	We report a case of a 72-year-old woman who presented with a 6-week history of profound confusion whilst being treated with rofecoxib, a COX-2 inhibitor.	rofecoxib	124-133	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-142
15210067-3	2004	The inhibitory effects of imrecoxib on mRNA level of COX-1 and COX-2 in human macrophage cell line U937 were detected by reverse transcription polymerase chain reaction (RT-PCR) analysis.	Imrecoxib	26-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-68
15298620-12	2004	PD98059 and SB203580 also suppressed serum-induced expression of COX-2 protein in HT29 cells.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-70
15298620-12	2004	PD98059 and SB203580 also suppressed serum-induced expression of COX-2 protein in HT29 cells.	SB 203580	12-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-70
15016613-5	2004	Application of 5 x 10(6) PMNs to the serosal surface of ischemia-injured mucosa significantly enhanced recovery of TER (P &lt; 0.05), an effect that was inhibited by the selective COX-2 inhibitor NS-398 (5 microM) and by an IL-1beta receptor antagonist (0.1 mg/ml).	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	196-202	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	180-185
15266215-2	2004	We evaluated cardiovascular event data for valdecoxib, a new COX-2-specific inhibitor in approximately 8000 patients with osteoarthritis and rheumatoid arthritis treated with this agent in randomized clinical trials.	valdecoxib	43-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-66
15187206-10	2004	Impairment of renal blood flow, leading to a decrease in the glomerular filtration rate, and increased proximal tubular absorption are the most likely mechanisms by which COX-2 selective inhibitors reduce lithium clearance.	Lithium	205-212	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	171-176
15155382-1	2004	OBJECTIVE: Inducible cyclooxygenase (COX-2) catalyzes the first step in prostanoid biosynthesis and is considered a proinflammatory enzyme.	Prostaglandins	72-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-42
15155382-8	2004	In vitro COX-2 inhibition in monocytes was associated with reduced MMP-9 release only when PGD2 pathway overcame PGE2 pathway.	Prostaglandin D2	91-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	9-14
15155382-8	2004	In vitro COX-2 inhibition in monocytes was associated with reduced MMP-9 release only when PGD2 pathway overcame PGE2 pathway.	Dinoprostone	113-117	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	9-14
14976130-6	2004	In contrast, cis-9, trans-11 had no effect on these proteins but had a clear effect on 5-LOX expression and to a lesser degree on COX-2 protein level isomers.	cis-9	13-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	130-135
14976130-6	2004	In contrast, cis-9, trans-11 had no effect on these proteins but had a clear effect on 5-LOX expression and to a lesser degree on COX-2 protein level isomers.	trans-11	20-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	130-135
15296324-3	2004	It was found that Co(II) and Ru(III) are the best metal catalysts for the activation of peroxymonosulfate.	Metals	50-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-24
15296324-3	2004	It was found that Co(II) and Ru(III) are the best metal catalysts for the activation of peroxymonosulfate.	peroxymonosulfate	88-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-24
15296324-8	2004	It was found that when Co(II), Ru(III), and Fe(II) interact with peroxymonosulfate, freely diffusible sulfate radicals are the primary species formed.	ru(iii)	31-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-29
15296324-8	2004	It was found that when Co(II), Ru(III), and Fe(II) interact with peroxymonosulfate, freely diffusible sulfate radicals are the primary species formed.	ammonium ferrous sulfate	44-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-29
15296324-8	2004	It was found that when Co(II), Ru(III), and Fe(II) interact with peroxymonosulfate, freely diffusible sulfate radicals are the primary species formed.	peroxymonosulfate	65-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-29
15296324-8	2004	It was found that when Co(II), Ru(III), and Fe(II) interact with peroxymonosulfate, freely diffusible sulfate radicals are the primary species formed.	sulfate radical	102-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-29
15254968-1	2004	Cyclooxygenase (COX)-2 is generally known as an inducible enzyme, and it produces arachidonic acid to prostaglandin E2 (PGE2), which modulates bone metabolism.	Dinoprostone	102-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-22
15254968-1	2004	Cyclooxygenase (COX)-2 is generally known as an inducible enzyme, and it produces arachidonic acid to prostaglandin E2 (PGE2), which modulates bone metabolism.	Dinoprostone	120-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-22
15254968-3	2004	Human mesenchymal stem cells constitutively expressed COX-2 as well as COX-1, and secretion of PGE2 was completely inhibited by NS-398, a specific inhibitor of COX-2.	Dinoprostone	95-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	160-165
15254968-3	2004	Human mesenchymal stem cells constitutively expressed COX-2 as well as COX-1, and secretion of PGE2 was completely inhibited by NS-398, a specific inhibitor of COX-2.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	128-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-59
15254968-3	2004	Human mesenchymal stem cells constitutively expressed COX-2 as well as COX-1, and secretion of PGE2 was completely inhibited by NS-398, a specific inhibitor of COX-2.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	128-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	160-165
15199082-1	2004	This study determined if meloxicam, a selective cyclooxygenase (COX)-2 inhibitor, interferes with the antiplatelet effect of aspirin using platelet aggregation and thromboxane (Tx) B(2) endpoints in healthy volunteers.	Meloxicam	25-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-70
15492414-5	2004	The PI3 kinase inhibitor LY294002 reduced COX-2 expression in HSC-5 cells and, contrary to our expectation, the phosphorylation of Akt was significantly decreased.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47
15492414-7	2004	COX-2 inhibitor NS398 up-regulated Akt phosphorylation.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	16-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
15229941-1	2004	OBJECTIVE: Cyclooxygenase (COX)-2 is an inducible eicosanoid-forming enzyme that is expressed at sites of inflammation.	Eicosanoids	50-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-33
15200656-1	2004	BACKGROUND: Rofecoxib is a selective COX-2 inhibitor that does not interfere with platelet function and is associated with fewer bleeding complications than other nonsteroidal anti-inflammatory agents (NSAIDs).	rofecoxib	12-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-42
15243281-0	2004	Raloxifene increases the capacity of serum to promote prostacyclin release in human endothelial cells: implication of COX-1 and COX-2.	Raloxifene Hydrochloride	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	128-133
15135241-6	2004	In amnion explants, HP (0-10 mm) induced COX-2 protein and PGE(2)release concomitant with apoptosis.	Hydrogen Peroxide	20-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-46
12898179-2	2004	In this study, we investigated the effect on cultured rheumatoid fibroblast-like synoviocytes (FLS) of the selective COX-2 inhibitor celecoxib on the expression of matrix metalloproteinases (MMPs), which play an important role in tissue degradation and angiogenesis in rheumatoid synovium.	Celecoxib	133-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-122
15232052-0	2004	Delirium From the COX-2 inhibitor refecoxib.	rofecoxib	34-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-23
15113997-1	2004	OBJECTIVE: To investigate the effects of the cyclooxygenase-2 (cox-2)-dependent prostaglandins D(2) (PGD(2)), E(2) (PGE(2)) and F(2)alpha (PGF(2)alpha) on the redifferentiation and cartilage matrix production of dedifferentiated articular chondrocytes.	Prostaglandin D2	80-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-68
15113997-1	2004	OBJECTIVE: To investigate the effects of the cyclooxygenase-2 (cox-2)-dependent prostaglandins D(2) (PGD(2)), E(2) (PGE(2)) and F(2)alpha (PGF(2)alpha) on the redifferentiation and cartilage matrix production of dedifferentiated articular chondrocytes.	Prostaglandins D	101-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-68
15113997-1	2004	OBJECTIVE: To investigate the effects of the cyclooxygenase-2 (cox-2)-dependent prostaglandins D(2) (PGD(2)), E(2) (PGE(2)) and F(2)alpha (PGF(2)alpha) on the redifferentiation and cartilage matrix production of dedifferentiated articular chondrocytes.	Prostaglandins E	116-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-68
15113997-1	2004	OBJECTIVE: To investigate the effects of the cyclooxygenase-2 (cox-2)-dependent prostaglandins D(2) (PGD(2)), E(2) (PGE(2)) and F(2)alpha (PGF(2)alpha) on the redifferentiation and cartilage matrix production of dedifferentiated articular chondrocytes.	Prostaglandins F	139-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-68
15206892-0	2004	Coordination complexes of 2-(4-quinolyl)nitronyl nitroxide with M(hfac)(2) [M = Mn(II), Co(II), and Cu(II)]: syntheses, crystal structures, and magnetic characterization.	2-(4-Quinolyl)nitronyl nitroxide	26-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-93
15193741-0	2004	Isolation, synthesis and characterization of impurities in celecoxib, a COX-2 inhibitor.	Celecoxib	59-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
15272234-5	2004	In addition, the induction of COX-2 and MMP-2 was inhibited by the pretreatment of chondrocytes with a SB203580 or Ro 31-8220, indicating the involvement of protein kinase C (PKC) or p38 mitogen-activated protein kinase (MAPK).	SB 203580	103-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-35
15214085-4	2004	Whereas the paramagnetic metal cations Cu(II), Fe(II), Ni(II), Co(II), and Mn(II) result in fluorescence quenching, the emission response is not altered by millimolar concentrations of Ca(II) or Mg(II), rendering the sensors selective for Zn(II) among all biologically important metal cations.	Metals	25-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-68
15198611-7	2004	Electronic structure calculations using density functional theory (DFT) reveal that the enhanced reaction rate for [L(8)py(2)Ni(SAr)](+) is rooted in a four-electron repulsion (or a "filled/filled interaction") between a completely filled nickel(II) d(pi) orbital and one of the two thiolate frontier orbitals, a condition that is absent in the Fe(II) and Co(II) complexes.	Nickel	239-245	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	356-362
15198611-7	2004	Electronic structure calculations using density functional theory (DFT) reveal that the enhanced reaction rate for [L(8)py(2)Ni(SAr)](+) is rooted in a four-electron repulsion (or a "filled/filled interaction") between a completely filled nickel(II) d(pi) orbital and one of the two thiolate frontier orbitals, a condition that is absent in the Fe(II) and Co(II) complexes.	thiolate	283-291	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	356-362
15198611-7	2004	Electronic structure calculations using density functional theory (DFT) reveal that the enhanced reaction rate for [L(8)py(2)Ni(SAr)](+) is rooted in a four-electron repulsion (or a "filled/filled interaction") between a completely filled nickel(II) d(pi) orbital and one of the two thiolate frontier orbitals, a condition that is absent in the Fe(II) and Co(II) complexes.	ammonium ferrous sulfate	345-351	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	356-362
15198611-9	2004	DFT calculations on putative thioether-coordinated intermediates reveal that the Co(II)- and Zn(II)-thioethers exhibit weaker M-S bonding than Ni(II).	Sulfides	29-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-87
15198611-9	2004	DFT calculations on putative thioether-coordinated intermediates reveal that the Co(II)- and Zn(II)-thioethers exhibit weaker M-S bonding than Ni(II).	Nickel(2+)	143-149	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-87
15214085-4	2004	Whereas the paramagnetic metal cations Cu(II), Fe(II), Ni(II), Co(II), and Mn(II) result in fluorescence quenching, the emission response is not altered by millimolar concentrations of Ca(II) or Mg(II), rendering the sensors selective for Zn(II) among all biologically important metal cations.	mg(ii)	195-201	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-68
15214085-4	2004	Whereas the paramagnetic metal cations Cu(II), Fe(II), Ni(II), Co(II), and Mn(II) result in fluorescence quenching, the emission response is not altered by millimolar concentrations of Ca(II) or Mg(II), rendering the sensors selective for Zn(II) among all biologically important metal cations.	Zinc	239-245	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-68
15214085-4	2004	Whereas the paramagnetic metal cations Cu(II), Fe(II), Ni(II), Co(II), and Mn(II) result in fluorescence quenching, the emission response is not altered by millimolar concentrations of Ca(II) or Mg(II), rendering the sensors selective for Zn(II) among all biologically important metal cations.	Metals	279-284	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-68
15217972-4	2004	Treatment of humans with the selective COX-2 inhibitor celecoxib augments the antitumor effects of chemotherapy in patients with non-small cell lung cancer.	Celecoxib	55-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-44
15217972-7	2004	However, prostaglandins derived from COX-2 affect other signaling pathways as well, such as the epidermal growth factor and its receptor.	Prostaglandins	9-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-42
14764449-3	2004	Previous research in our laboratory has shown that COX-2-elaborated prostanoids participate in recovery of mucosal barrier function in ischemic-injured porcine ileum.	Prostaglandins	68-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-56
15145695-6	2004	Catechin (COX 1 inhibitor) and NS398 (COX 2 inhibitor) were used at doses of 50 and 100 microM.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	31-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-43
15145696-3	2004	We hypothesized that a selective and commercially available COX-2 inhibitor, rofecoxib (Vioxx), would inhibit growth of Barrett"s adenocarcinoma and squamous cell carcinoma of the esophagus by apoptotic pathways.	rofecoxib	77-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-65
15145696-3	2004	We hypothesized that a selective and commercially available COX-2 inhibitor, rofecoxib (Vioxx), would inhibit growth of Barrett"s adenocarcinoma and squamous cell carcinoma of the esophagus by apoptotic pathways.	rofecoxib	88-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-65
14764449-7	2004	Western blot analysis revealed that SB-203580 inhibited upregulation of COX-2 that was observed in untreated ischemic-injured mucosa, whereas PD-98059 had no effect on COX-2 expression.	SB 203580	36-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
14764449-9	2004	The JNK inhibitor SP-600125 (0.1 mM) significantly increased TER and resulted in COX-2 upregulation.	pyrazolanthrone	18-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-86
15283037-4	2004	By contrast, COX-2 is only induced in response to inflammatory stimuli, resulting in the production of inflammation mediating prostaglandins.	Prostaglandins	126-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
15283037-10	2004	The salt retention induced by COX-2 inhibitors could also be the origin of an increase in blood pressure, and in susceptible subjects it could provoke cardiac decompensation.	Salts	4-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-35
15283043-3	2004	In addition, modulators of vascular growth, such as COX-2-generated prostanoids, contribute to the process by stabilizing the hypoxia-inducible factor and stimulating the expression of VEGF.	Prostaglandins	68-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-57
15309882-2	2004	We aimed to study the effects of the selective COX-2 inhibitor, nimesulide, on cell viability and telomerase and Akt/PKB activity in the human gastric cancer cell line MKN-45 and to explore the molecular mechanism for the antitumor activity of the selective COX-2 inhibitor.	nimesulide	64-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
15309882-2	2004	We aimed to study the effects of the selective COX-2 inhibitor, nimesulide, on cell viability and telomerase and Akt/PKB activity in the human gastric cancer cell line MKN-45 and to explore the molecular mechanism for the antitumor activity of the selective COX-2 inhibitor.	nimesulide	64-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	258-263
15309882-2	2004	We aimed to study the effects of the selective COX-2 inhibitor, nimesulide, on cell viability and telomerase and Akt/PKB activity in the human gastric cancer cell line MKN-45 and to explore the molecular mechanism for the antitumor activity of the selective COX-2 inhibitor.	mkn-45	168-174	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
15178312-1	2004	Four sensitive and accurate spectrophotometric methods have been developed for the assay of Acebutolol Hydrochloride (ACH), Atenolol (ATE) and Propranolol Hydrochloride (PRH), which are based on the complexation of drugs with copper(II) (Cu(II)) and cobalt(II) (Co(II)).	Acebutolol	92-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	250-260
15329003-3	2004	OBJECTIVE: The aim of this study was to evaluate the tolerability of three COX-2 inhibitors (meloxicam, celecoxib and rofecoxib) in subjects with previous pseudoallergic respiratory and cutaneous reactions to NSAIDs.	Meloxicam	93-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
15329003-3	2004	OBJECTIVE: The aim of this study was to evaluate the tolerability of three COX-2 inhibitors (meloxicam, celecoxib and rofecoxib) in subjects with previous pseudoallergic respiratory and cutaneous reactions to NSAIDs.	rofecoxib	118-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
15329003-8	2004	CONCLUSIONS: According to these results the cross-reactivity between aspirin and these COX-2 inhibitors does not occur in subjects with previous respiratory pseudoallergic reactions.	Aspirin	69-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-92
15178312-1	2004	Four sensitive and accurate spectrophotometric methods have been developed for the assay of Acebutolol Hydrochloride (ACH), Atenolol (ATE) and Propranolol Hydrochloride (PRH), which are based on the complexation of drugs with copper(II) (Cu(II)) and cobalt(II) (Co(II)).	Acebutolol	92-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	262-268
15178312-1	2004	Four sensitive and accurate spectrophotometric methods have been developed for the assay of Acebutolol Hydrochloride (ACH), Atenolol (ATE) and Propranolol Hydrochloride (PRH), which are based on the complexation of drugs with copper(II) (Cu(II)) and cobalt(II) (Co(II)).	Propranolol	143-168	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	250-260
15178312-1	2004	Four sensitive and accurate spectrophotometric methods have been developed for the assay of Acebutolol Hydrochloride (ACH), Atenolol (ATE) and Propranolol Hydrochloride (PRH), which are based on the complexation of drugs with copper(II) (Cu(II)) and cobalt(II) (Co(II)).	Propranolol	143-168	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	262-268
15178312-1	2004	Four sensitive and accurate spectrophotometric methods have been developed for the assay of Acebutolol Hydrochloride (ACH), Atenolol (ATE) and Propranolol Hydrochloride (PRH), which are based on the complexation of drugs with copper(II) (Cu(II)) and cobalt(II) (Co(II)).	Propranolol	170-173	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	250-260
15178312-1	2004	Four sensitive and accurate spectrophotometric methods have been developed for the assay of Acebutolol Hydrochloride (ACH), Atenolol (ATE) and Propranolol Hydrochloride (PRH), which are based on the complexation of drugs with copper(II) (Cu(II)) and cobalt(II) (Co(II)).	Propranolol	170-173	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	262-268
15178312-2	2004	The coloured products are measured at 613, 694, 548 and 614 nm for ACH-Co(II), ATE-Cu(II), PRH-Cu(II) and PRH-Co(II) method, respectively.	Acebutolol	67-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-77
15167967-4	2004	RESULTS: IL-1alpha-induced PGE2 production in synovial cells isolated from RA in primary culture was inhibited by mofezolac, a selective inhibitor of COX-1, as well as NS-398, a specific inhibitor of COX-2.	Dinoprostone	27-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	200-205
15289320-8	2004	Inhibition of AP-1 activation and COX-2 or VEGF transcriptional induction by this cyclopentenone was found to be independent of peroxisome proliferator-activated receptor-gamma (PPARgamma) because it was not affected by either expression of a dominant negative form of PPARgamma or the use of a PPARgamma antagonist.	cyclopentenone	82-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-39
15289320-10	2004	The antioxidant N-acetylcysteine significantly reversed the inhibition by 15d-PGJ(2) of AP-1 activity and COX-2 or VEGF transcriptional induction.	Acetylcysteine	16-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-111
15311562-0	2004	Lumiracoxib (Prexige): a new selective COX-2 inhibitor.	lumiracoxib	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-44
15311562-1	2004	Lumiracoxib, a new selective COX-2 inhibitor, has been recently approved in England and Mexico for the treatment of acute and chronic pain.	lumiracoxib	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34
15167967-4	2004	RESULTS: IL-1alpha-induced PGE2 production in synovial cells isolated from RA in primary culture was inhibited by mofezolac, a selective inhibitor of COX-1, as well as NS-398, a specific inhibitor of COX-2.	mofezolac	114-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	200-205
15167967-4	2004	RESULTS: IL-1alpha-induced PGE2 production in synovial cells isolated from RA in primary culture was inhibited by mofezolac, a selective inhibitor of COX-1, as well as NS-398, a specific inhibitor of COX-2.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	168-174	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	200-205
15167967-9	2004	The induction of both COX-1 and COX-2 was inhibited by dexamethasone.	Dexamethasone	55-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-37
15160322-4	2004	Using a post-marketing surveillance study (PSS) efficacy and tolerability of the COX-2-selective drug Celecoxib was evaluated.	Celecoxib	102-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-86
14762100-2	2004	Acetylation of COX-2 by aspirin activates a transcellular biosynthetic pathway that switches eicosanoid biosynthesis from prostaglandin E(2) to 15-epi-lipoxin (LX)A(4) or aspirin-triggered lipoxin (ATL).	Aspirin	24-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-20
14762100-2	2004	Acetylation of COX-2 by aspirin activates a transcellular biosynthetic pathway that switches eicosanoid biosynthesis from prostaglandin E(2) to 15-epi-lipoxin (LX)A(4) or aspirin-triggered lipoxin (ATL).	Eicosanoids	93-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-20
14762100-2	2004	Acetylation of COX-2 by aspirin activates a transcellular biosynthetic pathway that switches eicosanoid biosynthesis from prostaglandin E(2) to 15-epi-lipoxin (LX)A(4) or aspirin-triggered lipoxin (ATL).	Prostaglandins E	122-137	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-20
14762100-2	2004	Acetylation of COX-2 by aspirin activates a transcellular biosynthetic pathway that switches eicosanoid biosynthesis from prostaglandin E(2) to 15-epi-lipoxin (LX)A(4) or aspirin-triggered lipoxin (ATL).	15-epi-lipoxin	144-158	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-20
14762100-2	2004	Acetylation of COX-2 by aspirin activates a transcellular biosynthetic pathway that switches eicosanoid biosynthesis from prostaglandin E(2) to 15-epi-lipoxin (LX)A(4) or aspirin-triggered lipoxin (ATL).	lx	160-162	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-20
14762100-2	2004	Acetylation of COX-2 by aspirin activates a transcellular biosynthetic pathway that switches eicosanoid biosynthesis from prostaglandin E(2) to 15-epi-lipoxin (LX)A(4) or aspirin-triggered lipoxin (ATL).	Aspirin	171-178	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-20
14762100-2	2004	Acetylation of COX-2 by aspirin activates a transcellular biosynthetic pathway that switches eicosanoid biosynthesis from prostaglandin E(2) to 15-epi-lipoxin (LX)A(4) or aspirin-triggered lipoxin (ATL).	Lipoxins	151-158	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-20
15233140-10	2004	(5) Parecoxib is marketed as "Cox-2-specific inhibitor", but follow-up is too short to show whether this property avoids the severe adverse effects seen with other NSAIDs, such as renal failure, gastrointestinal haemorrhage, and delayed wound healing.	parecoxib	4-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-35
15663000-0	2004	QSAR and classification models of a novel series of COX-2 selective inhibitors: 1,5-diarylimidazoles based on support vector machines.	1,5-diarylimidazoles	80-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-57
15106969-2	2004	However, Co(III) can bind water far more strongly than Co(II) as a sixth ligand, so that the competition between water and NO complexation strongly favors water for Co(III) in the gas phase.	Water	113-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-61
15024003-7	2004	The addition of PGE(2) to macrophage cultures stimulates their expression of both urokinase-type plasminogen activator and MMP-9, and the selective COX-2 inhibitor NS-398 blocks ECM-induced proteinase expression.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	164-170	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	148-153
15024003-8	2004	Moreover, ECM-induced PGE(2) and MMP-9 expression by elicited COX-2(-/-) macrophages is markedly reduced when compared with the response of either COX-2(+/-) or COX-2(+/+) macrophages.	Prostaglandins E	22-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
15105053-0	2004	Integrin-linked kinase (ILK) regulation of the cell viability in PTEN mutant glioblastoma and in vitro inhibition by the specific COX-2 inhibitor NS-398.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	146-152	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	130-135
15105053-4	2004	The selective COX-2 inhibitor NS-398 was found capable of down-regulating ILK and PKB/Akt phosphorylation.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	30-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
15252628-1	2004	The complex formation of Co(II) and Cd(II) with mixed N/O ligands in dimethylsulfoxide (dmso) at 298 K is investigated by means of potentiometric, UV-Vis, calorimetric, FT-IR, NMR and electrochemical techniques.	Dimethyl Sulfoxide	69-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-31
15252628-1	2004	The complex formation of Co(II) and Cd(II) with mixed N/O ligands in dimethylsulfoxide (dmso) at 298 K is investigated by means of potentiometric, UV-Vis, calorimetric, FT-IR, NMR and electrochemical techniques.	Dimethyl Sulfoxide	88-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-31
15252628-4	2004	DFT studies are also performed to gain an insight into the stabilization of the lower oxidation state of the CoL2(2+/3+) couple in order to understand the different reactivity of the Co(II) complexes towards dioxygen.	Oxygen	208-216	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	183-189
15150618-1	2004	This case-control study of 310 colorectal cancer cases and 1177 controls in a nested prospective, population-based cohort of Singapore Chinese subjects found a statistically significant association between the cyclooxygenase (COX)-2 -765G&gt;C gene polymorphism and colon cancer risk among high consumers of dietary n-6 polyunsaturated fatty acids (odds ratio=2.38, 95% confidence interval=1.23-4.59).	n-6 polyunsaturated fatty acids	316-347	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	210-232
15118886-9	2004	The non-selective cyclo-oxygenase inhibitor ASA and the selective COX-2 inhibitor sulindac only had a minor effect on endothelial cell migration, however, the COX-2 inhibitor sulindac showed a synergistic effect with the thromboxane synthase inhibitor.	Sulindac	82-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-71
15020596-2	2004	It has been shown to target prostaglandin H(2) synthase (COX)-1 and COX-2, which catalyze the first committed step in the synthesis of prostaglandins via sequential cyclooxygenase and peroxidase reactions.	Prostaglandins	135-149	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-73
15069660-0	2004	Enantioselective HPLC determination of E-6087, a new COX-2 inhibitor, in human plasma: Validation and pharmacokinetic application.	enflicoxib	39-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-58
15118886-9	2004	The non-selective cyclo-oxygenase inhibitor ASA and the selective COX-2 inhibitor sulindac only had a minor effect on endothelial cell migration, however, the COX-2 inhibitor sulindac showed a synergistic effect with the thromboxane synthase inhibitor.	Sulindac	175-183	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	159-164
15106969-2	2004	However, Co(III) can bind water far more strongly than Co(II) as a sixth ligand, so that the competition between water and NO complexation strongly favors water for Co(III) in the gas phase.	Water	113-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-61
15106969-3	2004	Although the Co(II) oxidation state is found to bind water slightly more strongly than NO in the gas phase, the inclusion of solvation effects via the polarizeable continuum model makes NO binding more favorable.	Water	53-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-19
15110946-3	2004	The structures of 1 and 2 were determined by X-ray diffraction analysis, which shows that N3- and NCS- coordinate to the Co(II) ions of 1 and 2, respectively, with the Co-N bond lengths of 1.992(6) A and 1.901(3) A.	co-n	168-172	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-127
15111350-5	2004	Cox-2 is an inducible enzyme involved with prostaglandin synthesis.	Prostaglandins	43-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
15111350-14	2004	Cox-2 inhibitors such as NS-398 have been shown to enhance the effects of radiotherapy.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	25-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
14715488-7	2004	In perinatal NB DA, PAF receptor antagonists BN-52021 and THG-315 reduced mPGES, COX-2, and PGE(2) levels and were associated with increased DA tone.	Thioguanine	58-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-86
15001457-1	2004	OBJECTIVE: In endothelial cells, cyclooxygenase-1 (COX-1) and COX-2 both contribute to prostacyclin production.	Epoprostenol	87-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
15001457-2	2004	Recent findings suggest that COX-2 contributes significantly to systemic prostacyclin synthesis in humans; whether COX-2 inhibition is related to an increased cardiovascular risk is undergoing debate.	Epoprostenol	73-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34
15001457-7	2004	As a consequence of COX-2-induction by HDL3 prostacyclin production increased, incubation with a COX-2 selective inhibitor blocked this effect.	Epoprostenol	44-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-25
15001457-7	2004	As a consequence of COX-2-induction by HDL3 prostacyclin production increased, incubation with a COX-2 selective inhibitor blocked this effect.	Epoprostenol	44-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
15110946-7	2004	The aqua Co(II) complex must be the reactive catalytic species in the catalyzed dehydration reaction and the rate-determining step is the substitution of the labile water molecule by HCO3-.	Water	165-170	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	9-15
15110946-7	2004	The aqua Co(II) complex must be the reactive catalytic species in the catalyzed dehydration reaction and the rate-determining step is the substitution of the labile water molecule by HCO3-.	Bicarbonates	183-187	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	9-15
15110946-9	2004	The inhibition ability of NCS- is stronger than that of N3-, which can be rationalized by the decreases in the Co-N(N3-/NCS-) bond lengths and effective atomic charges of the Co(II) ions based on the X-ray crystallographic data and theoretical calculations in this work.	co-n	111-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	175-181
14729581-0	2004	Benzo[a]pyrene phenols are more potent inducers of CYP1A1, CYP1B1 and COX-2 than benzo[a]pyrene glucuronides in cell lines derived from the human aerodigestive tract.	benzo[a]pyrene phenols	0-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-75
15899629-4	2004	Cox2 is involved in the conversion of arachidonic acid into prostaglandins and thromboxanes, as well as the synthesis of malonaldehyde (MDA, a mutagen) and the production of hydrogen peroxide, which promotes carcinogenesis.	Arachidonic Acid	38-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-4
15899629-4	2004	Cox2 is involved in the conversion of arachidonic acid into prostaglandins and thromboxanes, as well as the synthesis of malonaldehyde (MDA, a mutagen) and the production of hydrogen peroxide, which promotes carcinogenesis.	Prostaglandins	60-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-4
15239333-4	2004	Cox2 is involved in the conversion of arachidonic acid into prostaglandins and thromboxanes, as well as the synthesis of malonaldehyde (MDA, a mutagen) and the production of hydrogen peroxide, which promotes carcinogenesis.	Arachidonic Acid	38-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-4
15239333-4	2004	Cox2 is involved in the conversion of arachidonic acid into prostaglandins and thromboxanes, as well as the synthesis of malonaldehyde (MDA, a mutagen) and the production of hydrogen peroxide, which promotes carcinogenesis.	Prostaglandins	60-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-4
15239333-4	2004	Cox2 is involved in the conversion of arachidonic acid into prostaglandins and thromboxanes, as well as the synthesis of malonaldehyde (MDA, a mutagen) and the production of hydrogen peroxide, which promotes carcinogenesis.	Thromboxanes	79-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-4
15899629-4	2004	Cox2 is involved in the conversion of arachidonic acid into prostaglandins and thromboxanes, as well as the synthesis of malonaldehyde (MDA, a mutagen) and the production of hydrogen peroxide, which promotes carcinogenesis.	Thromboxanes	79-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-4
14751545-3	2004	Tyrosine kinase inhibitor (genistein), phosphatidylcholine-specific phospholipase C (PC-PLC) inhibitor (D-609) and PKC inhibitor (GF109203X) attenuated TNF-alpha-induced COX-2 expression and PGE2 synthesis in HTSMCs.	bisindolylmaleimide I	130-139	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	170-175
15899629-4	2004	Cox2 is involved in the conversion of arachidonic acid into prostaglandins and thromboxanes, as well as the synthesis of malonaldehyde (MDA, a mutagen) and the production of hydrogen peroxide, which promotes carcinogenesis.	Malondialdehyde	121-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-4
15899629-4	2004	Cox2 is involved in the conversion of arachidonic acid into prostaglandins and thromboxanes, as well as the synthesis of malonaldehyde (MDA, a mutagen) and the production of hydrogen peroxide, which promotes carcinogenesis.	Hydrogen Peroxide	174-191	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-4
15899631-5	2004	In this paper we will discuss the scientific proofs and potential interest of Cox2 inhibitors in the treatment of PAF.	Platelet Activating Factor	114-117	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-82
15899633-6	2004	Alimentary factors like resveratrol or insaturated fat acid reduce Cox2 expression in animal and could be investigated in human studies.	Resveratrol	24-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-71
15239333-4	2004	Cox2 is involved in the conversion of arachidonic acid into prostaglandins and thromboxanes, as well as the synthesis of malonaldehyde (MDA, a mutagen) and the production of hydrogen peroxide, which promotes carcinogenesis.	Malondialdehyde	121-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-4
15239333-4	2004	Cox2 is involved in the conversion of arachidonic acid into prostaglandins and thromboxanes, as well as the synthesis of malonaldehyde (MDA, a mutagen) and the production of hydrogen peroxide, which promotes carcinogenesis.	Hydrogen Peroxide	174-191	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-4
15239335-5	2004	In this paper we will discuss the scientific proofs and potential interest of Cox2 inhibitors in the treatment of PAF.	Platelet Activating Factor	114-117	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-82
15239337-6	2004	Alimentary factors like resveratrol or insaturated fat acid reduce Cox2 expression in animal and could be investigated in human studies.	Resveratrol	24-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-71
14751545-4	2004	TNF-alpha-induced COX-2 expression and PGE2 synthesis were also inhibited by PD98059 (an inhibitor of MEK1/2) and SB203580 and SB202190 (inhibitors of p38 MAPK), respectively, suggesting the involvement of p42/p44 and p38 MAPKs in these responses.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	77-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-23
15239337-6	2004	Alimentary factors like resveratrol or insaturated fat acid reduce Cox2 expression in animal and could be investigated in human studies.	fat acid	51-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-71
15239337-7	2004	Clinical trials are planed with the anti Cox2 celecoxib for breast cancer prevention, in adjuvant setting, in metastatic situation combined with exemestane or antitubulin drugs or in neoadjuvant therapy.	Celecoxib	46-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-45
15899633-6	2004	Alimentary factors like resveratrol or insaturated fat acid reduce Cox2 expression in animal and could be investigated in human studies.	fat acid	51-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-71
15899633-7	2004	Clinical trials are planed with the anti Cox2 celecoxib for breast cancer prevention, in adjuvant setting, in metastatic situation combined with exemestane or antitubulin drugs or in neoadjuvant therapy.	Celecoxib	46-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-45
14751545-4	2004	TNF-alpha-induced COX-2 expression and PGE2 synthesis were also inhibited by PD98059 (an inhibitor of MEK1/2) and SB203580 and SB202190 (inhibitors of p38 MAPK), respectively, suggesting the involvement of p42/p44 and p38 MAPKs in these responses.	SB 203580	114-122	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-23
14751545-4	2004	TNF-alpha-induced COX-2 expression and PGE2 synthesis were also inhibited by PD98059 (an inhibitor of MEK1/2) and SB203580 and SB202190 (inhibitors of p38 MAPK), respectively, suggesting the involvement of p42/p44 and p38 MAPKs in these responses.	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	127-135	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-23
15285921-1	2004	The cyclooxygenase (COX) enzymes (COX-1 and COX-2) are key enzymes of prostaglandin (PG) biosynthesis.	Prostaglandins	70-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-49
15285921-1	2004	The cyclooxygenase (COX) enzymes (COX-1 and COX-2) are key enzymes of prostaglandin (PG) biosynthesis.	Prostaglandins	85-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-49
15100590-1	2004	OBJECTIVE: To compare the overall analgesic effect, including time to onset, peak and duration of effect for etoricoxib 120 mg, a new COX-2 selective inhibitor, in patients with acute pain to that of placebo.	Etoricoxib	109-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-139
15136366-0	2004	Rofecoxib, a COX-2 inhibitor, lowers C-reactive protein and interleukin-6 levels in patients with acute coronary syndromes.	rofecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
15136366-2	2004	AIM: To evaluate whether patients with ACS treated with rofecoxib, a COX-2 inhibitor, will have reduced CRP, IL-6, and soluble tumor necrotic factor receptor-1 (sTNF-R1) levels and improved endothelial function.	rofecoxib	56-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-74
14751545-7	2004	TNF-alpha-induced COX-2 expression and PGE2 synthesis was also inhibited by NF-kappaB inhibitor pyrrolidinedithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	96-122	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-23
14751545-7	2004	TNF-alpha-induced COX-2 expression and PGE2 synthesis was also inhibited by NF-kappaB inhibitor pyrrolidinedithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	124-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-23
14751545-8	2004	These findings suggest that the increased expression of COX-2 correlates with the release of PGE2 from TNF-alpha-challenged HTSMCs, at least in part, mediated through p42/p44 and p38 MAPKs as well as NF-kappaB signaling pathways in HTSMCs.	Dinoprostone	93-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-61
15100590-8	2004	DISCUSSION: Etoricoxib is a new COX-2 selective inhibitor under development for treatment of osteoarthritis, rheumatoid arthritis, and acute pain.	Etoricoxib	12-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-37
15131052-2	2004	EXPERIMENTAL DESIGN: Immunohistochemistry was performed on paraffin-embedded sections by using rabbit antiserum against COX-2.	Paraffin	59-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-125
15136101-9	2004	Pretreatment of HUMEC with a selective COX-2 inhibitor, NS-398, abolished E(2)-induced PGE(2) synthesis, suggesting that E(2) specifically up-regulates COX-2 activity.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	56-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-44
15136101-9	2004	Pretreatment of HUMEC with a selective COX-2 inhibitor, NS-398, abolished E(2)-induced PGE(2) synthesis, suggesting that E(2) specifically up-regulates COX-2 activity.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	56-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-157
15117884-2	2004	Selective inhibitors of COX-2, such as celecoxib, etoricoxib, lumiracoxib, rofecoxib, and valdecoxib have been developed and the greatest recent growth in our knowledge in this area has been come from the clinical use of these compounds.	Celecoxib	39-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
15117884-2	2004	Selective inhibitors of COX-2, such as celecoxib, etoricoxib, lumiracoxib, rofecoxib, and valdecoxib have been developed and the greatest recent growth in our knowledge in this area has been come from the clinical use of these compounds.	Etoricoxib	50-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
15136101-9	2004	Pretreatment of HUMEC with a selective COX-2 inhibitor, NS-398, abolished E(2)-induced PGE(2) synthesis, suggesting that E(2) specifically up-regulates COX-2 activity.	Estradiol	74-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-44
15117884-2	2004	Selective inhibitors of COX-2, such as celecoxib, etoricoxib, lumiracoxib, rofecoxib, and valdecoxib have been developed and the greatest recent growth in our knowledge in this area has been come from the clinical use of these compounds.	lumiracoxib	62-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
15136101-9	2004	Pretreatment of HUMEC with a selective COX-2 inhibitor, NS-398, abolished E(2)-induced PGE(2) synthesis, suggesting that E(2) specifically up-regulates COX-2 activity.	Estradiol	74-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-157
15117884-2	2004	Selective inhibitors of COX-2, such as celecoxib, etoricoxib, lumiracoxib, rofecoxib, and valdecoxib have been developed and the greatest recent growth in our knowledge in this area has been come from the clinical use of these compounds.	rofecoxib	75-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
15136101-9	2004	Pretreatment of HUMEC with a selective COX-2 inhibitor, NS-398, abolished E(2)-induced PGE(2) synthesis, suggesting that E(2) specifically up-regulates COX-2 activity.	Dinoprostone	87-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-44
15117884-2	2004	Selective inhibitors of COX-2, such as celecoxib, etoricoxib, lumiracoxib, rofecoxib, and valdecoxib have been developed and the greatest recent growth in our knowledge in this area has been come from the clinical use of these compounds.	valdecoxib	90-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
15136101-9	2004	Pretreatment of HUMEC with a selective COX-2 inhibitor, NS-398, abolished E(2)-induced PGE(2) synthesis, suggesting that E(2) specifically up-regulates COX-2 activity.	Dinoprostone	87-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-157
15136101-9	2004	Pretreatment of HUMEC with a selective COX-2 inhibitor, NS-398, abolished E(2)-induced PGE(2) synthesis, suggesting that E(2) specifically up-regulates COX-2 activity.	Estradiol	89-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-44
15136101-9	2004	Pretreatment of HUMEC with a selective COX-2 inhibitor, NS-398, abolished E(2)-induced PGE(2) synthesis, suggesting that E(2) specifically up-regulates COX-2 activity.	Estradiol	89-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-157
15102867-0	2004	Parecoxib sodium, an injectable COX-2-specific inhibitor, does not affect unfractionated heparin-regulated blood coagulation parameters.	parecoxib	0-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-37
15067356-4	2004	COX-2 plays an important role in tumor cell biology, taking part actively in angiogenesis particularly via the production of prostaglandin E2 (PGE2).	Dinoprostone	125-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
15067356-4	2004	COX-2 plays an important role in tumor cell biology, taking part actively in angiogenesis particularly via the production of prostaglandin E2 (PGE2).	Dinoprostone	143-147	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
15067356-10	2004	PGE2 production was higher in mutated-PTEN expressing phospho-Akt and COX-2 compared to wild-type PTEN cells.	Dinoprostone	0-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-75
15067356-11	2004	Inhibition of PI 3-K with Wortmannin and LY294002 blocked Akt phosphorylation and inhibited expression of COX-2 in mutated-PTEN cells.	Wortmannin	26-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-111
15067356-11	2004	Inhibition of PI 3-K with Wortmannin and LY294002 blocked Akt phosphorylation and inhibited expression of COX-2 in mutated-PTEN cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	41-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-111
15067356-15	2004	Specific inhibition of COX-2 with NS-398 induced apoptosis in COX-2 expressing human endometrial cancer cells.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	34-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-28
15067356-15	2004	Specific inhibition of COX-2 with NS-398 induced apoptosis in COX-2 expressing human endometrial cancer cells.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	34-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
15067366-0	2004	The role of selective COX-2 inhibitors in reactive oxygen species formation in osteosarcoma cells after X-ray irradiation.	Reactive Oxygen Species	42-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-27
15067366-4	2004	Our results showed that the presence of COX-2 inhibitor without irradiation results in faint spots of ROS formation that do not appear in the absence of COX-2 inhibitor.	Reactive Oxygen Species	102-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
15051429-3	2004	Aspartic acid slightly enhanced the adsorption of Pb(II), Zn(II), and Co(II) at low pH, but inhibited the adsorption of all the metal ions at higher pH.	Aspartic Acid	0-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-76
15051429-7	2004	Cu(II) and Co(II) form complexes with aspartic acid more strongly than the other metals.	Aspartic Acid	38-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-17
15067222-5	2004	IL-1beta-induced COX-2 expression and PGE(2) synthesis were also inhibited by an inhibitor of MEK1/2 (PD98059) and inhibitors of p38 MAPK (SB203580 and SB202190), respectively, suggesting the involvement of p42/p44 and p38 MAPKs in these responses.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	102-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22
15067222-8	2004	IL-1beta-induced COX-2 expression and PGE(2) synthesis were inhibited by the NF-kappaB inhibitor pyrrolidinedithiocarbamate.	pyrrolidine dithiocarbamic acid	97-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22
15067222-9	2004	These findings suggest that the expression of COX-2 is correlated with the release of PGE(2) from IL-1beta-challenged HTSMCs, which is mediated, at least in part, through p42/p44 and p38 MAPKs and NF-kappaB signaling pathways in HTSMCs.	Prostaglandins E	86-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
15102867-8	2004	These results show that a full analgesic dose of parecoxib, a COX-2-specific inhibitor available for parenteral administration, can be coadministered with UFH without affecting blood coagulation parameters.	parecoxib	49-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
15134917-2	2004	In 10% methanol/water, the one-electron reduction of quinones L1 and L2 to the corresponding semiquinones is shifted to more positive potentials upon addition of one equivalent of Zn(II), Ni(II), Co(II) or Cd(II) and is consistent with formation of a 1:1 complex involving the quinone(N) and adjacent quinone(O).	Methanol	7-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	196-202
15051429-8	2004	As these complexes do not adsorb, Cu(II) and Co(II) suffer greater suppression from aspartic acid than the other metals.	Aspartic Acid	84-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-51
15134917-2	2004	In 10% methanol/water, the one-electron reduction of quinones L1 and L2 to the corresponding semiquinones is shifted to more positive potentials upon addition of one equivalent of Zn(II), Ni(II), Co(II) or Cd(II) and is consistent with formation of a 1:1 complex involving the quinone(N) and adjacent quinone(O).	Water	16-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	196-202
15134917-2	2004	In 10% methanol/water, the one-electron reduction of quinones L1 and L2 to the corresponding semiquinones is shifted to more positive potentials upon addition of one equivalent of Zn(II), Ni(II), Co(II) or Cd(II) and is consistent with formation of a 1:1 complex involving the quinone(N) and adjacent quinone(O).	Quinones	53-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	196-202
15134917-2	2004	In 10% methanol/water, the one-electron reduction of quinones L1 and L2 to the corresponding semiquinones is shifted to more positive potentials upon addition of one equivalent of Zn(II), Ni(II), Co(II) or Cd(II) and is consistent with formation of a 1:1 complex involving the quinone(N) and adjacent quinone(O).	semiquinones	93-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	196-202
15134917-2	2004	In 10% methanol/water, the one-electron reduction of quinones L1 and L2 to the corresponding semiquinones is shifted to more positive potentials upon addition of one equivalent of Zn(II), Ni(II), Co(II) or Cd(II) and is consistent with formation of a 1:1 complex involving the quinone(N) and adjacent quinone(O).	quinone	53-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	196-202
15134917-2	2004	In 10% methanol/water, the one-electron reduction of quinones L1 and L2 to the corresponding semiquinones is shifted to more positive potentials upon addition of one equivalent of Zn(II), Ni(II), Co(II) or Cd(II) and is consistent with formation of a 1:1 complex involving the quinone(N) and adjacent quinone(O).	quinone	97-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	196-202
15134918-2	2004	UV-Vis spectroscopy demonstrates tight 1:1 complex formation between Co(II) and IAA.	indoleacetic acid	80-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-75
15051429-1	2004	The effect of aspartic acid on the adsorption of Pb(II), Cu(II), Zn(II), Co(II), and Mn(II) on kaolinite at 25 degrees C in the presence of 5 mM KNO3 was investigated by means of potentiometric titrations and adsorption measurements over a range of pH and concentration.	Aspartic Acid	14-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-79
15134918-3	2004	The intensity of the S--&gt;Co(II) charge transfer bands at 304 and 340 nm and the ligand field bands between 630 and 728 nm indicate Co(II) coordination by the four cysteine thiolates of IAA in a pseudo-tetrahedral geometry.	cysteine thiolate	166-184	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-140
15134918-3	2004	The intensity of the S--&gt;Co(II) charge transfer bands at 304 and 340 nm and the ligand field bands between 630 and 728 nm indicate Co(II) coordination by the four cysteine thiolates of IAA in a pseudo-tetrahedral geometry.	indoleacetic acid	188-191	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-140
15134918-4	2004	A dissociation constant value of 5.3 microM was determined for the Co(II)-IAA complex at pH 6.5.	indoleacetic acid	74-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-73
15134918-5	2004	Zn(II) readily displaces Co(II) from IAA as evinced by loss of the Co(II) spectral features.	Zinc	0-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-31
15134918-5	2004	Zn(II) readily displaces Co(II) from IAA as evinced by loss of the Co(II) spectral features.	Zinc	0-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-30
15134918-6	2004	The dissociation constant for Zn(II), 20 pM at pH 6.5, was determined be competition experiments with Co(II)-IAA.	Zinc	30-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-108
15134918-6	2004	The dissociation constant for Zn(II), 20 pM at pH 6.5, was determined be competition experiments with Co(II)-IAA.	indoleacetic acid	109-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-108
15133778-6	2004	After adjusting for potential confounding factors, the OR for switching to another NS-NSAID or COX-2 specific inhibitor ranged from 1.74 to 2.35 for the three NS-NSAIDs compared to celecoxib (all comparisons, p &lt; 0.01).	Celecoxib	181-190	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-100
15182793-1	2004	OBJECTIVES: Two selective COX2 inhibitors, rofecoxib and celecoxib, were introduced on the French market in 2000.	rofecoxib	43-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-30
15182793-1	2004	OBJECTIVES: Two selective COX2 inhibitors, rofecoxib and celecoxib, were introduced on the French market in 2000.	Celecoxib	57-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-30
15133778-9	2004	CONCLUSIONS: Patients on the COX-2 specific inhibitors (celecoxib and rofecoxib) were significantly less likely to switch their therapy than patients on NS-NSAIDS (ibuprofen, naproxen and diclofenac).	Celecoxib	56-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34
15133778-9	2004	CONCLUSIONS: Patients on the COX-2 specific inhibitors (celecoxib and rofecoxib) were significantly less likely to switch their therapy than patients on NS-NSAIDS (ibuprofen, naproxen and diclofenac).	rofecoxib	70-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34
15133778-9	2004	CONCLUSIONS: Patients on the COX-2 specific inhibitors (celecoxib and rofecoxib) were significantly less likely to switch their therapy than patients on NS-NSAIDS (ibuprofen, naproxen and diclofenac).	Diclofenac	188-198	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34
15084117-3	2004	Our data demonstrate that pyrazole ring substituents play an important role in COX-2 selective inhibition, such that a cycloalkyl pyrazole (6b) was found to be a potent and selective COX-2 inhibitor.	pyrazole	26-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-84
15270001-1	2004	Etoricoxib (Arcoxia) is a novel non steroidal anti-inflammatory drug (NSAID) that selectively inhibits the inducible form of cyclo-oxygenase (COX), COX-2.	Etoricoxib	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	148-153
15270001-2	2004	Etoricoxib has a higher COX-1/COX-2 selectivity ratio than the other COX-2-selective NSAIDs as rofecoxib, valdecoxib or celecoxib.	Etoricoxib	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-35
15063780-0	2004	Butyrate suppresses Cox-2 activation in colon cancer cells through HDAC inhibition.	Butyrates	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-25
15063780-4	2004	The HDAC inhibitors butyrate and TSA blocked the TNF-alpha activation of Cox-2 protein and mRNA synthesis, and dramatically suppressed Cox-2 activity in HT-29 cells.	Butyrates	20-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-78
15063780-4	2004	The HDAC inhibitors butyrate and TSA blocked the TNF-alpha activation of Cox-2 protein and mRNA synthesis, and dramatically suppressed Cox-2 activity in HT-29 cells.	Butyrates	20-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-140
15063780-4	2004	The HDAC inhibitors butyrate and TSA blocked the TNF-alpha activation of Cox-2 protein and mRNA synthesis, and dramatically suppressed Cox-2 activity in HT-29 cells.	trichostatin A	33-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-78
15063780-4	2004	The HDAC inhibitors butyrate and TSA blocked the TNF-alpha activation of Cox-2 protein and mRNA synthesis, and dramatically suppressed Cox-2 activity in HT-29 cells.	trichostatin A	33-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-140
15084746-9	2004	Furthermore, the arachidonate-induced up-regulation of PECAM-1 was abrogated by indomethacin [a cyclooxygenase (COX)-1 and -2 inhibitor] or N-[2-(cyclohexyloxy)-4-nitrophenyl]-methanesulfonamide (a COX-2 inhibitor) but not nordihydroguaiaretic acid (a lipoxygenase inhibitor).	Arachidonic Acid	17-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	198-203
15084746-9	2004	Furthermore, the arachidonate-induced up-regulation of PECAM-1 was abrogated by indomethacin [a cyclooxygenase (COX)-1 and -2 inhibitor] or N-[2-(cyclohexyloxy)-4-nitrophenyl]-methanesulfonamide (a COX-2 inhibitor) but not nordihydroguaiaretic acid (a lipoxygenase inhibitor).	Indomethacin	80-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	198-203
15084746-9	2004	Furthermore, the arachidonate-induced up-regulation of PECAM-1 was abrogated by indomethacin [a cyclooxygenase (COX)-1 and -2 inhibitor] or N-[2-(cyclohexyloxy)-4-nitrophenyl]-methanesulfonamide (a COX-2 inhibitor) but not nordihydroguaiaretic acid (a lipoxygenase inhibitor).	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	140-194	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	198-203
15050636-1	2004	4-[4-(N-Acetylsulfonamido)phenyl]-3-(4-methanesulfonylphenyl)-2(5H)furanone, possessing a N-acetylsulfonamido pharmacophore, has been identified as a potent and selective COX-2 inhibitor that has the potential to acetylate the COX-2 isozyme.	4-(4-(N-acetylsulfonamido)phenyl)-3-(4-methanesulfonylphenyl)-2(5H)-furanone	0-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	171-176
15875396-0	2004	Retention of Co(II), Ni(II), and Cu(II) on a purified brown humic acid.	Humic Substances	60-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-19
15875396-4	2004	The aim of this work is to study the retention mechanisms of Cu(II), Ni(II), and Co(II) on a BHA by means of a proper combination of physical and chemical techniques: sorption isotherms, mathematical modeling of these isotherms, molecular modeling, FTIR, and N2 (77 K) and CO2 (273 K) adsorption.	Nitrogen	259-261	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-87
15084117-3	2004	Our data demonstrate that pyrazole ring substituents play an important role in COX-2 selective inhibition, such that a cycloalkyl pyrazole (6b) was found to be a potent and selective COX-2 inhibitor.	cycloalkyl pyrazole	119-138	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-84
15050636-1	2004	4-[4-(N-Acetylsulfonamido)phenyl]-3-(4-methanesulfonylphenyl)-2(5H)furanone, possessing a N-acetylsulfonamido pharmacophore, has been identified as a potent and selective COX-2 inhibitor that has the potential to acetylate the COX-2 isozyme.	4-(4-(N-acetylsulfonamido)phenyl)-3-(4-methanesulfonylphenyl)-2(5H)-furanone	0-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	227-232
15084117-3	2004	Our data demonstrate that pyrazole ring substituents play an important role in COX-2 selective inhibition, such that a cycloalkyl pyrazole (6b) was found to be a potent and selective COX-2 inhibitor.	cycloalkyl pyrazole	119-138	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	183-188
15050636-1	2004	4-[4-(N-Acetylsulfonamido)phenyl]-3-(4-methanesulfonylphenyl)-2(5H)furanone, possessing a N-acetylsulfonamido pharmacophore, has been identified as a potent and selective COX-2 inhibitor that has the potential to acetylate the COX-2 isozyme.	n-acetylsulfonamido	90-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	171-176
15050636-1	2004	4-[4-(N-Acetylsulfonamido)phenyl]-3-(4-methanesulfonylphenyl)-2(5H)furanone, possessing a N-acetylsulfonamido pharmacophore, has been identified as a potent and selective COX-2 inhibitor that has the potential to acetylate the COX-2 isozyme.	n-acetylsulfonamido	90-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	227-232
15084117-3	2004	Our data demonstrate that pyrazole ring substituents play an important role in COX-2 selective inhibition, such that a cycloalkyl pyrazole (6b) was found to be a potent and selective COX-2 inhibitor.	6B	140-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-84
15084117-3	2004	Our data demonstrate that pyrazole ring substituents play an important role in COX-2 selective inhibition, such that a cycloalkyl pyrazole (6b) was found to be a potent and selective COX-2 inhibitor.	6B	140-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	183-188
15084117-4	2004	Other modifications at the 3 position of the central pyrazole ring (17b, 23b, 26b-I) enhanced COX-2 inhibitory potency.	pyrazole	53-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-99
15084117-5	2004	Among the pyrazoles synthesized, the oxime (23b) was identified as the most potent COX-2 selective inhibitor.	Pyrazoles	10-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
15084117-5	2004	Among the pyrazoles synthesized, the oxime (23b) was identified as the most potent COX-2 selective inhibitor.	Oximes	37-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
15074995-2	2004	The kinetics and thermodynamics of these reactions show that the reactivity of these complexes is affected by metal electronic structure and falls into three groups: Mn(II) and Ni(II) complexes are the most reactive, Fe(II) and Co(II) complexes exhibit intermediate reactivity, and Cu(II) and Zn(II) complexes are the least reactive.	Metals	110-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	228-234
18969387-1	2004	A simple, sensitive and rapid derivative spectrophotometric method using 2-(5-bromo-2-pyridylazo)-5-diethylaminophenol (5-Br-PADAP) has been developed for simultaneous determination of Co(II), Ni(II) and Fe(II) which have very similar chemical behavior and appear together in many real samples.	2-(5-bromo-2-pyridylazo)-5-diethylaminophenol	73-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	185-191
15074995-2	2004	The kinetics and thermodynamics of these reactions show that the reactivity of these complexes is affected by metal electronic structure and falls into three groups: Mn(II) and Ni(II) complexes are the most reactive, Fe(II) and Co(II) complexes exhibit intermediate reactivity, and Cu(II) and Zn(II) complexes are the least reactive.	Manganese(2+)	166-172	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	228-234
15074995-2	2004	The kinetics and thermodynamics of these reactions show that the reactivity of these complexes is affected by metal electronic structure and falls into three groups: Mn(II) and Ni(II) complexes are the most reactive, Fe(II) and Co(II) complexes exhibit intermediate reactivity, and Cu(II) and Zn(II) complexes are the least reactive.	Nickel(2+)	177-183	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	228-234
15074995-2	2004	The kinetics and thermodynamics of these reactions show that the reactivity of these complexes is affected by metal electronic structure and falls into three groups: Mn(II) and Ni(II) complexes are the most reactive, Fe(II) and Co(II) complexes exhibit intermediate reactivity, and Cu(II) and Zn(II) complexes are the least reactive.	cu(ii)	282-288	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	228-234
15074995-2	2004	The kinetics and thermodynamics of these reactions show that the reactivity of these complexes is affected by metal electronic structure and falls into three groups: Mn(II) and Ni(II) complexes are the most reactive, Fe(II) and Co(II) complexes exhibit intermediate reactivity, and Cu(II) and Zn(II) complexes are the least reactive.	Zinc	293-299	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	228-234
18969387-1	2004	A simple, sensitive and rapid derivative spectrophotometric method using 2-(5-bromo-2-pyridylazo)-5-diethylaminophenol (5-Br-PADAP) has been developed for simultaneous determination of Co(II), Ni(II) and Fe(II) which have very similar chemical behavior and appear together in many real samples.	Nickel(2+)	193-199	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	185-191
18969387-1	2004	A simple, sensitive and rapid derivative spectrophotometric method using 2-(5-bromo-2-pyridylazo)-5-diethylaminophenol (5-Br-PADAP) has been developed for simultaneous determination of Co(II), Ni(II) and Fe(II) which have very similar chemical behavior and appear together in many real samples.	ammonium ferrous sulfate	204-210	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	185-191
18969387-6	2004	Concentrations of Co(II) and Ni(II) were calculated from the total (2)D values and the sum of the linear equations for these three cations at 640 and 600nm, after Fe(II) assay by making use of the (2)D value at 740nm.	ammonium ferrous sulfate	163-169	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-24
18969387-1	2004	A simple, sensitive and rapid derivative spectrophotometric method using 2-(5-bromo-2-pyridylazo)-5-diethylaminophenol (5-Br-PADAP) has been developed for simultaneous determination of Co(II), Ni(II) and Fe(II) which have very similar chemical behavior and appear together in many real samples.	2-(5-bromo-2-pyridylazo)-5-diethylaminophenol	120-130	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	185-191
15087416-0	2004	Correspondence re: M. V. Swamy et al., Inhibition of COX-2 in colon cancer cell lines by celecoxib increases the nuclear localization of active p53.	Celecoxib	89-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-58
15051057-0	2004	Synthesis and biological evaluation of 2,3-diarylpyrazines and quinoxalines as selective COX-2 inhibitors.	2,3-diarylpyrazines	39-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-94
15051057-0	2004	Synthesis and biological evaluation of 2,3-diarylpyrazines and quinoxalines as selective COX-2 inhibitors.	Quinoxalines	63-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-94
15051057-1	2004	Several 2,3-diaryl pyrazines and quinoxalines with 4-sulfamoyl (SO(2)NH(2))/methylsulfonyl (SO(2)Me)-phenyl pharmacophores have been synthesized and evaluated for the cyclooxygenase (COX-1/COX-2) inhibitory activity.	2,3-diaryl pyrazines	8-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	189-194
15051057-1	2004	Several 2,3-diaryl pyrazines and quinoxalines with 4-sulfamoyl (SO(2)NH(2))/methylsulfonyl (SO(2)Me)-phenyl pharmacophores have been synthesized and evaluated for the cyclooxygenase (COX-1/COX-2) inhibitory activity.	Quinoxalines	33-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	189-194
15051057-1	2004	Several 2,3-diaryl pyrazines and quinoxalines with 4-sulfamoyl (SO(2)NH(2))/methylsulfonyl (SO(2)Me)-phenyl pharmacophores have been synthesized and evaluated for the cyclooxygenase (COX-1/COX-2) inhibitory activity.	4-sulfamoyl	51-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	189-194
15041464-5	2004	The effect of celecoxib treatment on both, cell survival and induction of apoptosis in hCOX-2-as cells was less marked than in the COX-2-expressing cells.	Celecoxib	14-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-93
15051057-1	2004	Several 2,3-diaryl pyrazines and quinoxalines with 4-sulfamoyl (SO(2)NH(2))/methylsulfonyl (SO(2)Me)-phenyl pharmacophores have been synthesized and evaluated for the cyclooxygenase (COX-1/COX-2) inhibitory activity.	methylsulfonyl	76-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	189-194
15051057-1	2004	Several 2,3-diaryl pyrazines and quinoxalines with 4-sulfamoyl (SO(2)NH(2))/methylsulfonyl (SO(2)Me)-phenyl pharmacophores have been synthesized and evaluated for the cyclooxygenase (COX-1/COX-2) inhibitory activity.	so(2)me	92-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	189-194
14732711-1	2004	In vertebrates, COX-1 and COX-2, two cyclooxygenase isozymes with different physiological functions and gene regulation, catalyze identical reactions in prostaglandin synthesis.	Prostaglandins	153-166	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-31
14961568-3	2004	Unlike primary normal mesothelial cells, the selective cyclooxygenase (COX)-2 inhibitor celecoxib reduced the in vitro proliferation of several MM cells derived from previously untreated MM patients.	Celecoxib	88-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-77
14961568-5	2004	Celecoxib was more efficient in inhibiting MM cell growth than acetylsalicylic acid (10(-6) M-10(-2) M), indometacin (10(-6) M-10(-2) M) and the COX-2 inhibitor NS-398 (10(-6) M-10(-4) M).	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-150
15020231-6	2004	Catalase-induced COX-2 expression was abrogated by treatment of MG-132 (a NF-kappaB inhibitor) or LY294002 (a PI3K inhibitor), but not by treatment of PD98059 (an ERK inhibitor), SB203580 (a p38 inhibitor), or SP600125 (a JNK inhibitor).	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	64-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22
14742435-9	2004	Our results suggest that COX-2/PGE(2) may exert pro-oncogenic effects through synergistic induction of receptor tyrosine kinase-dependent signaling pathway, thus, provide a novel mechanism for the combinatorial treatment of colonic neoplasms targeting both COX-2/PGE(2) and the EGFR system that has demonstrated remarkable advantages.	Prostaglandins E	31-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-30
14742435-9	2004	Our results suggest that COX-2/PGE(2) may exert pro-oncogenic effects through synergistic induction of receptor tyrosine kinase-dependent signaling pathway, thus, provide a novel mechanism for the combinatorial treatment of colonic neoplasms targeting both COX-2/PGE(2) and the EGFR system that has demonstrated remarkable advantages.	Prostaglandins E	31-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	257-262
14742435-9	2004	Our results suggest that COX-2/PGE(2) may exert pro-oncogenic effects through synergistic induction of receptor tyrosine kinase-dependent signaling pathway, thus, provide a novel mechanism for the combinatorial treatment of colonic neoplasms targeting both COX-2/PGE(2) and the EGFR system that has demonstrated remarkable advantages.	Prostaglandins E	263-266	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-30
15020231-6	2004	Catalase-induced COX-2 expression was abrogated by treatment of MG-132 (a NF-kappaB inhibitor) or LY294002 (a PI3K inhibitor), but not by treatment of PD98059 (an ERK inhibitor), SB203580 (a p38 inhibitor), or SP600125 (a JNK inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	98-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22
15020235-3	2004	We have observed that the COX-2 inhibitor celecoxib inhibits growth and induces apoptosis in the immortalized breast epithelial cell line 184htert.	Celecoxib	42-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-31
15020231-6	2004	Catalase-induced COX-2 expression was abrogated by treatment of MG-132 (a NF-kappaB inhibitor) or LY294002 (a PI3K inhibitor), but not by treatment of PD98059 (an ERK inhibitor), SB203580 (a p38 inhibitor), or SP600125 (a JNK inhibitor).	SB 203580	179-187	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22
15020231-6	2004	Catalase-induced COX-2 expression was abrogated by treatment of MG-132 (a NF-kappaB inhibitor) or LY294002 (a PI3K inhibitor), but not by treatment of PD98059 (an ERK inhibitor), SB203580 (a p38 inhibitor), or SP600125 (a JNK inhibitor).	pyrazolanthrone	210-218	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22
15048787-4	2004	At 0.38 mM PBAD enhanced production of HO(*) from H(2)O(2) in the presence of Co(II) up to 90%, as measured by a deoxyribose assay.	Holmium	39-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-84
15020231-7	2004	Moreover, inhibition of PI3K by LY294002 caused partial decrease of catalase-induced COX-2 transcription and steady-state COX-2 transcript levels, but not COX-2 mRNA stability.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-90
15048787-4	2004	At 0.38 mM PBAD enhanced production of HO(*) from H(2)O(2) in the presence of Co(II) up to 90%, as measured by a deoxyribose assay.	Hydrogen Peroxide	50-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-84
15020231-7	2004	Moreover, inhibition of PI3K by LY294002 caused partial decrease of catalase-induced COX-2 transcription and steady-state COX-2 transcript levels, but not COX-2 mRNA stability.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-127
15020231-7	2004	Moreover, inhibition of PI3K by LY294002 caused partial decrease of catalase-induced COX-2 transcription and steady-state COX-2 transcript levels, but not COX-2 mRNA stability.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-127
14977803-3	2004	This study tested the hypothesis that the COX-2-selective inhibitor rofecoxib has less influence on platelet function than the NSAID diclofenac in gynaecological surgery.	rofecoxib	68-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47
14720556-7	2004	The adsorption of Cu(II), Co(II), and Cd(II) on the beads was significantly rapid and reached at equilibrium within 10 min at 25 degrees C. Adsorption isotherms of the metal ions on the beads exhibited Freundlich and/or Langmuir behavior, contrary to gel beads either of alginate or chitosan showing a step-wise shape of adsorption isotherm.	Metals	168-173	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-31
15048787-5	2004	Using the spin trap agent 5,5-dimethyl-1-pyrroline-N-oxide, it was found that the amplitude of the signal arising from the Fenton-like reaction [Co(II)/H(2)O(2)] was significantly diminished by the test compounds.	5,5-dimethyl-1-pyrroline-1-oxide	26-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-151
15023855-10	2004	TNF alpha-induced PGE(2) biosynthesis was significantly enhanced by the simultaneous addition of IFN gamma and was COX-2 dependent.	Dinoprostone	18-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-120
15023855-14	2004	These results suggest that, in terms of PGE(2) biosynthesis, IFN gamma plays a negative regulatory role at the level of COX-2 expression and a positive regulatory role at the level of mPGES expression.	Dinoprostone	40-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-125
15054499-8	2004	Moreover, because CINODs suppress the activity of both COX-1 and COX-2, they do not share with selective COX-2 inhibitors the lack of cardioprotection afforded by significant suppression of platelet aggregation.	cinods	18-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-70
14720556-7	2004	The adsorption of Cu(II), Co(II), and Cd(II) on the beads was significantly rapid and reached at equilibrium within 10 min at 25 degrees C. Adsorption isotherms of the metal ions on the beads exhibited Freundlich and/or Langmuir behavior, contrary to gel beads either of alginate or chitosan showing a step-wise shape of adsorption isotherm.	Alginates	271-279	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-31
15010021-10	2004	Nonsteroidal anti-inflammatory drug therapy with sulindac, a nonselective cyclooxygenase (COX) inhibitor, or celecoxib, a COX-2 selective inhibitor, may be of benefit after the development of duodenal polyposis by inducing the regression or stabilization of the polyposis, although there is limited evidence from randomized, controlled trials to support its routine use.	Celecoxib	109-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-127
15078741-10	2004	COX-1 and COX-2 activity was determined by measuring serum thromboxane (TX) B(2) and endotoxin-induced PGE(2) generation in whole blood.	Thromboxanes	59-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
15078741-10	2004	COX-1 and COX-2 activity was determined by measuring serum thromboxane (TX) B(2) and endotoxin-induced PGE(2) generation in whole blood.	Prostaglandins E	103-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
15078741-12	2004	RESULTS: At the doses used, nimesulide was selective for COX-2, while ibuprofen was nonselective based on serum TXB(2) levels.	nimesulide	28-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-62
15078741-15	2004	CONCLUSIONS: Increases in spinal PG synthesis after thoracotomy are repressed by a selective COX-2 inhibitor.	Prostaglandins	33-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-98
15078741-16	2004	This suggests that the inducible COX-2 mediates central PG synthesis, which may be important in the generation of pain, as the use of nimesulide also resulted in significant decreases in postoperative pain perception.	Prostaglandins	56-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-38
15078741-16	2004	This suggests that the inducible COX-2 mediates central PG synthesis, which may be important in the generation of pain, as the use of nimesulide also resulted in significant decreases in postoperative pain perception.	nimesulide	134-144	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-38
15063354-4	2004	The discovery that macrophage COX-2 is downregulated by oxidized low-density lipoprotein and liver X receptors indicates coordinated and reciprocal control of cholesterol homeostasis and inflammatory pathways.	Cholesterol	159-170	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-35
15063354-6	2004	Concerns have been raised that inhibition of COX-2 might promote thrombotic cardiovascular events by disturbing the balance between platelet thromboxane A2 and endothelial prostacyclin.	Thromboxane A2	141-155	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-50
14977876-0	2004	COX-2 inhibitors selectively block prostacyclin synthesis in endotoxin-exposed vascular smooth muscle cells.	Epoprostenol	35-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
15063354-6	2004	Concerns have been raised that inhibition of COX-2 might promote thrombotic cardiovascular events by disturbing the balance between platelet thromboxane A2 and endothelial prostacyclin.	Epoprostenol	172-184	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-50
15086362-3	2004	OBJECTIVES: To study the effects of COX2 inhibitor rofecoxib on platelet function using in vitro tests.	rofecoxib	51-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-40
15072847-0	2004	Quantitative structure activity relationship studies of diaryl furanones as selective COX-2 inhibitors.	diaryl furanones	56-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-91
15072847-2	2004	QSAR studies have been performed on a series of diaryl furanones that acts as selective COX-2 inhibitor using Molecular Operating Environment (MOE).	diaryl furanones	48-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-93
14977876-6	2004	Specific COX-2 inhibitors completely blocked PGI2 formation but PGE2 synthesis only partially.	Epoprostenol	45-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	9-14
15766158-4	2004	There is a linear relationship in the range of 0.0-8.5 microg x mL(-1) for Fe(II); of 0.0-7.3 microg x mL(-1) for Cu(I); and of 0.0-5.9 microg x mL(-1) for Co(II).	ammonium ferrous sulfate	75-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	156-162
15060721-8	2004	The mother tincture of Solanum dulcamara inhibited the production of PGE2 by COX 1 (IC50 40 microg/ml) and COX 2 (IC50 150 microg/ml) but not production of leukotriene LTB4 by 5-LOX.	Dinoprostone	69-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-112
15161117-1	2004	Two randomised, multicentre, double-blind, placebo- and active-controlled, 3-way crossover studies were performed to evaluate the efficacy and tolerability of the novel COX-2 selective inhibitor lumiracoxib in the treatment of primary dysmenorrhoea.	lumiracoxib	195-206	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	169-174
15047734-6	2004	CONCLUSIONS: COX-2 is overexpressed in liver cirrhosis, and possibly contributes to prostaglandin overproduction, which may be a major component of the inflammation and hyperdynamic circulation associated with cirrhosis.	Prostaglandins	84-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
15082814-0	2004	Applying a research ethics committee approach to a medical practice controversy: the case of the selective COX-2 inhibitor rofecoxib.	rofecoxib	123-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-112
15082814-3	2004	This marketing continues even though a pivotal safety study with one of the COX-2 inhibitors, rofecoxib, showed a significant increase in myocardial infarction with rofecoxib use compared with a traditional anti-inflammatory drug.	rofecoxib	94-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-81
15082814-3	2004	This marketing continues even though a pivotal safety study with one of the COX-2 inhibitors, rofecoxib, showed a significant increase in myocardial infarction with rofecoxib use compared with a traditional anti-inflammatory drug.	rofecoxib	165-174	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-81
15050982-4	2004	In vivo studies have found the specific COX-2 inhibitors rofecoxib (Vioxx) and valdecoxib (Bextra) effective in treatment of primary dysmenorrhea in women &gt;or=18 years.	rofecoxib	57-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
15050982-4	2004	In vivo studies have found the specific COX-2 inhibitors rofecoxib (Vioxx) and valdecoxib (Bextra) effective in treatment of primary dysmenorrhea in women &gt;or=18 years.	rofecoxib	68-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
15050982-4	2004	In vivo studies have found the specific COX-2 inhibitors rofecoxib (Vioxx) and valdecoxib (Bextra) effective in treatment of primary dysmenorrhea in women &gt;or=18 years.	valdecoxib	79-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
15050982-4	2004	In vivo studies have found the specific COX-2 inhibitors rofecoxib (Vioxx) and valdecoxib (Bextra) effective in treatment of primary dysmenorrhea in women &gt;or=18 years.	valdecoxib	91-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
15182039-1	2004	Valdecoxib (Bextra tablets of 10 mg and 20 mg) is a new non steroidal antiinflammatory drug (NSAID) that selectively inhibits COX-2 isoform of cyclo-oxygenase.	valdecoxib	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-131
15182039-1	2004	Valdecoxib (Bextra tablets of 10 mg and 20 mg) is a new non steroidal antiinflammatory drug (NSAID) that selectively inhibits COX-2 isoform of cyclo-oxygenase.	valdecoxib	12-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-131
15252926-4	2004	Cyclooxygenase enzymes are required for the conversion of arachidonic acid to prostaglandins.COX-2 mediates the inflammatory effects of COX activity, is induced by a wide spectrum of growth factors and proinflammatory cytokines, and is overexpressed in numerous premalignant and malignant lesions, including CRC.	Arachidonic Acid	58-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-98
15252926-4	2004	Cyclooxygenase enzymes are required for the conversion of arachidonic acid to prostaglandins.COX-2 mediates the inflammatory effects of COX activity, is induced by a wide spectrum of growth factors and proinflammatory cytokines, and is overexpressed in numerous premalignant and malignant lesions, including CRC.	Prostaglandins	78-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-98
15252926-5	2004	Treatment with the selective COX-2 inhibitor celecoxib has shown promising results in the prevention of CRC, Numerous studies show that this COX-2 selective inhibitor is a potent suppressor of colon polyps both in animal models for familial adenomatous polyposis and in patients with this condition.	Celecoxib	45-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34
15252926-5	2004	Treatment with the selective COX-2 inhibitor celecoxib has shown promising results in the prevention of CRC, Numerous studies show that this COX-2 selective inhibitor is a potent suppressor of colon polyps both in animal models for familial adenomatous polyposis and in patients with this condition.	Celecoxib	45-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	141-146
15312381-1	2004	OBJECTIVE: To study the effects of nimesulide, a selective COX-2 inhibitor, on cell viability, telomerase and PKB activities in human gastric cancer cell line SGC7901 and to explore its molecular mechanism of selective growth inhibition.	nimesulide	35-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-64
15312381-6	2004	CONCLUSION: Selective COX-2 inhibitor nimesulide inhibits telomerase activity of gastric cancer cells by partly blocking the activation of protein kinase B.	nimesulide	38-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-27
15037537-3	2004	Recently, we have demonstrated enhanced expression of inducible cyclooxygenase (COX) and prostaglandin (PG)E2-dependent synthase (COX-2/mPGES-1) in human symptomatic plaques and provided evidence that it is associated with metalloproteinase (MMP)-induced plaque rupture.	prostaglandin (pg	89-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	130-135
15037537-4	2004	Thus, the aim of this study was to characterize the effect of the angiotensin II type 1 (AT1) receptor antagonist irbesartan on the inflammatory infiltration and expression of COX-2/mPGES-1 and MMPs in human carotid plaques.	Irbesartan	114-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	176-181
15037537-8	2004	Plaques from the irbesartan group had fewer (P&lt;0.0001) macrophages, T lymphocytes, and HLA-DR+ cells; less (P&lt;0.0001) immunoreactivity for COX-2/mPGES-1 and MMPs; reduced (P&lt;0.0001) gelatinolytic activity; and increased (P&lt;0.0001) collagen content.	Irbesartan	17-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-150
15037537-9	2004	It is worth noting that COX-2/mPGES-1 inhibition was observed after incubation in vitro with irbesartan but not with the selective AT2 blockade PD123,319.	Irbesartan	93-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
15037537-10	2004	CONCLUSIONS: This study demonstrates that irbesartan decreases inflammation and inhibits COX-2/mPGES-1 expression in plaque macrophages, and this effect may in turn contribute to plaque stabilization by inhibition of MMP-induced plaque rupture.	Irbesartan	42-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-94
15010798-0	2004	A novel mixed-valence complex containing Co(II)(2)Co(III)(2) molecular squares with 4,5-imidazoledicarboxylate bridges.	co(iii)	50-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-47
15010798-0	2004	A novel mixed-valence complex containing Co(II)(2)Co(III)(2) molecular squares with 4,5-imidazoledicarboxylate bridges.	1H-Imidazole-4,5-dicarboxylic acid	84-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-47
15010798-1	2004	A heterometallic complex, Na(2)[Co(II)(2)Co(III)(2)(IDC(3-))(4)(bipy)(4)].12H(2)O (bipy = 2,2"-bipyridine), in which mixed-valence tetranuclear squares with imidazoledicarboxylate (IDC(3-)) linkers are tethered into a unique chain through disodium units, is hydrothermally synthesized and structurally and magnetically characterized.	sodium sulfide	26-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-38
14726416-8	2004	The treatment of this liquid culture with indomethacin, a dual inhibitor of COX-1 and COX-2, and NS-398, a COX-2-specific inhibitor, suppressed megakaryocyte differentiation.	Indomethacin	42-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-91
14726416-8	2004	The treatment of this liquid culture with indomethacin, a dual inhibitor of COX-1 and COX-2, and NS-398, a COX-2-specific inhibitor, suppressed megakaryocyte differentiation.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	97-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-112
15089030-3	2004	Most 8-arylflavones exhibited much reduced inhibitory activities against COX-2 catalyzed PGE2 production compared to that of wogonin.	8-arylflavones	5-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-78
15089030-3	2004	Most 8-arylflavones exhibited much reduced inhibitory activities against COX-2 catalyzed PGE2 production compared to that of wogonin.	Dinoprostone	89-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-78
14633654-4	2004	In this study, human colorectal carcinoma HCT-116 cells were treated with the Cox-1 specific inhibitor SC-560 and the Cox-2 specific inhibitor SC-58125 to evaluate their ability to induce apoptosis, inhibit cell proliferation, inhibit growth on soft agar and modulate gene expression.	1-((4-methylsulfonyl)phenyl)-3-trifluoromethyl-5-(4-fluorophenyl)pyrazole	143-151	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-123
14633654-12	2004	In conclusion, this is the first report to suggest that like sulindac sulfide, the Cox-1 specific inhibitor SC-560 appears to elicit chemo-preventative activity by altering gene expression, while the chemo-preventative effects of SC-58125 are complex and probably work through these and other mechanisms, such as the inhibition of Cox-2.	SC 560	108-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	331-336
14764109-7	2004	Acivicin, a selective gamma-glutamyltranspeptidase inhibitor, counteracted H. pylori-induced upregulation of COX-2 and EGF-related peptide mRNA expression.	acivicin	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-114
14988266-4	2004	High glucose treatment of THP-1 monocytic cells led to a significant three- to fivefold induction of COX-2 mRNA and protein expression but not COX-1 mRNA.	Glucose	5-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-106
14988266-5	2004	High glucose-induced COX-2 mRNA was blocked by inhibitors of nuclear factor-kappaB (NF-kappaB), protein kinase C, and p38 mitogen-activated protein kinase.	Glucose	5-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-26
14988266-6	2004	In addition, an antioxidant and inhibitors of mitochondrial superoxide, NADPH oxidase, and glucose metabolism to glucosamine also blocked high glucose-induced COX-2 expression to varying degrees.	Superoxides	60-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	159-164
14988266-6	2004	In addition, an antioxidant and inhibitors of mitochondrial superoxide, NADPH oxidase, and glucose metabolism to glucosamine also blocked high glucose-induced COX-2 expression to varying degrees.	Glucose	91-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	159-164
14988266-6	2004	In addition, an antioxidant and inhibitors of mitochondrial superoxide, NADPH oxidase, and glucose metabolism to glucosamine also blocked high glucose-induced COX-2 expression to varying degrees.	Glucosamine	113-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	159-164
14988266-6	2004	In addition, an antioxidant and inhibitors of mitochondrial superoxide, NADPH oxidase, and glucose metabolism to glucosamine also blocked high glucose-induced COX-2 expression to varying degrees.	Glucose	143-150	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	159-164
14988266-7	2004	High glucose significantly increased transcription from a human COX-2 promoter-luciferase construct (twofold, P &lt; 0.001).	Glucose	5-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-69
15049901-1	2004	AIMS: Cyclooxygenase (COX), which catalyses the synthesis of prostaglandins from arachidonic acid, has two isoforms; COX-1 and COX-2.	Prostaglandins	61-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	127-132
15049901-1	2004	AIMS: Cyclooxygenase (COX), which catalyses the synthesis of prostaglandins from arachidonic acid, has two isoforms; COX-1 and COX-2.	Arachidonic Acid	81-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	127-132
15010822-12	2004	Treatment of the COX-2 overexpressing cells with a COX-2-selective inhibitor, NS-398 (10 microM), decreased PGE2 level and attenuated VEGF expression.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	78-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22
15010822-12	2004	Treatment of the COX-2 overexpressing cells with a COX-2-selective inhibitor, NS-398 (10 microM), decreased PGE2 level and attenuated VEGF expression.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	78-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-56
15010822-12	2004	Treatment of the COX-2 overexpressing cells with a COX-2-selective inhibitor, NS-398 (10 microM), decreased PGE2 level and attenuated VEGF expression.	Dinoprostone	108-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22
15010822-12	2004	Treatment of the COX-2 overexpressing cells with a COX-2-selective inhibitor, NS-398 (10 microM), decreased PGE2 level and attenuated VEGF expression.	Dinoprostone	108-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-56
15010822-15	2004	Moreover, COX-2 up-regulates VEGF expression in HCC cells, possibly via PGs production.	Prostaglandins	72-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
15125136-3	2004	Indomethacin and the new nitric oxide (NO)-donating NSAIDs block the activity of both COX-1 and COX-2.	Indomethacin	0-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-101
15125136-3	2004	Indomethacin and the new nitric oxide (NO)-donating NSAIDs block the activity of both COX-1 and COX-2.	Nitric Oxide	25-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-101
15020063-3	2004	A link between the immune-mediated inflammatory response and glutamate-mediated excitotoxicity of oligodendrocytes could involve the interaction of inducible isoforms of nitric oxide synthase (iNOS) and cyclooxygenase (COX-2).	Glutamic Acid	61-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	219-224
15203612-9	2004	Randomised placebo controlled trials are required to assess fully the benefit of COX-2 selective and specific prostaglandin synthesis inhibitors.	Prostaglandins	110-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-86
15047127-11	2004	In addition, COX-2 mRNA expression and COX-2 protein induced by LPS were also reduced by levamisole.	Levamisole	89-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
15047127-11	2004	In addition, COX-2 mRNA expression and COX-2 protein induced by LPS were also reduced by levamisole.	Levamisole	89-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-44
15047127-14	2004	The inhibition of levamisole occurs at the transcription level of COX-2 gene and is regulated through NF-kappaB activation.	Levamisole	18-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-71
15290792-3	2004	Proliferation of both of the MCF-7/hCox-2 clones was significantly inhibited in a time- and dose-dependent manner by celecoxib.	Celecoxib	117-126	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-41
15290792-6	2004	These results demonstrate that hCox-2 directly increases breast tumor cell proliferation, stimulates invasion across a basement membrane, and induces synthesis of specific heparin binding splice variants of VEGF.	Heparin	172-179	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-37
15032369-1	2004	Co(II), Zn(II), Ni(II) and Fe(I) were successfully separated by capillary electrophoresis using pre-capillary and on-capillary complexation with 4-(2-thiazolylazo)resorcinol.	4-(2-thiazolylazo)resorcinol	145-173	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
14980665-1	2004	Loxoprofen, its trans-alcohol and cis-alcohol metabolites were evaluated for selectivity of inhibition of COX-2 over COX-1.	loxoprofen	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-111
14980665-2	2004	The (2S,1"R,2"S)-trans-alcohol derivative was found to be the most active metabolite and to be a potent and nonselective inhibitor of COX-2 and COX-1 in both enzyme and human whole blood assays.	(2s,1"r,2"s)-trans-alcohol	4-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-139
15252489-9	2004	[Co(II)(5)3]2+ can be oxidised to Delta-[Co(III)(5H2)3]9+.	delta-[co(iii)(5h2)3]9	34-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	1-7
15252489-10	2004	Formation constants for both [Co(II)(5)3]2+ and [Co(II)(5H2)3]8+ in acetonitrile were obtained by spectrophotometric titrations.	acetonitrile	68-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-36
15252489-10	2004	Formation constants for both [Co(II)(5)3]2+ and [Co(II)(5H2)3]8+ in acetonitrile were obtained by spectrophotometric titrations.	acetonitrile	68-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-55
15252489-11	2004	In the former case, the stability constant, log beta3 = 19.5(8), is very similar to that measured for [Co(II)(bipy)3]2+ (log beta3 = 19.3(7)) but this drops significantly when the amine groups of are protonated (log beta3 = 16.5(2)).	Amines	180-185	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-109
15252489-12	2004	A dynamic combinatorial library was prepared by mixing three equivalents of, three equivalents of bipy, and two equivalents of Co(II) in CD3CN.	Acetonitrile-d3	137-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	127-133
15252489-13	2004	The presence of all possible Delta- and Lambda-[Co(II)(5)x(bipy)(3-x)]2+ complexes was inferred from 1H NMR and ES-MS spectra.	Hydrogen	101-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-54
15252489-14	2004	Addition of protons to this library reduced the number of components by inducing diastereoselectivity, and presence of chloride further simplified the 1H NMR spectrum, indicating that [Cl2 ligand Delta-[Co(II)(5H2)3]]6+ and [Co(II)(bipy)3]2+ were the dominant products.	Chlorides	119-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	203-209
15252489-14	2004	Addition of protons to this library reduced the number of components by inducing diastereoselectivity, and presence of chloride further simplified the 1H NMR spectrum, indicating that [Cl2 ligand Delta-[Co(II)(5H2)3]]6+ and [Co(II)(bipy)3]2+ were the dominant products.	Chlorine	185-188	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	203-209
15252489-14	2004	Addition of protons to this library reduced the number of components by inducing diastereoselectivity, and presence of chloride further simplified the 1H NMR spectrum, indicating that [Cl2 ligand Delta-[Co(II)(5H2)3]]6+ and [Co(II)(bipy)3]2+ were the dominant products.	Chlorine	185-188	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	225-231
15068300-0	2004	Synthesis of a new oxime and its application to the construction of a highly selective and sensitive Co(II) PVC-based membrane sensor.	Oximes	19-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-106
15068300-6	2004	The practical utility of the sensor has been demonstrated by using it as an indicator electrode in the potentiometric titration of Co2+ with EDTA and for the direct determination of Co(II) in wastewater of the electroplating industry.	Cobalt(2+)	131-135	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	182-188
15068300-6	2004	The practical utility of the sensor has been demonstrated by using it as an indicator electrode in the potentiometric titration of Co2+ with EDTA and for the direct determination of Co(II) in wastewater of the electroplating industry.	Edetic Acid	141-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	182-188
15163023-1	2004	Cyclooxygenase (COX)-2, the recently described inducible form ofcyclooxygenase, has been shown to be responsible for the inflammatory and tumorigenic effects of prostaglandins; hence the development and expanding clinical use of COX-2 selective inhibitors termed super aspirins.	Prostaglandins	161-175	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-22
15163023-1	2004	Cyclooxygenase (COX)-2, the recently described inducible form ofcyclooxygenase, has been shown to be responsible for the inflammatory and tumorigenic effects of prostaglandins; hence the development and expanding clinical use of COX-2 selective inhibitors termed super aspirins.	Prostaglandins	161-175	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	229-234
15163023-1	2004	Cyclooxygenase (COX)-2, the recently described inducible form ofcyclooxygenase, has been shown to be responsible for the inflammatory and tumorigenic effects of prostaglandins; hence the development and expanding clinical use of COX-2 selective inhibitors termed super aspirins.	Aspirin	269-277	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-22
15163023-1	2004	Cyclooxygenase (COX)-2, the recently described inducible form ofcyclooxygenase, has been shown to be responsible for the inflammatory and tumorigenic effects of prostaglandins; hence the development and expanding clinical use of COX-2 selective inhibitors termed super aspirins.	Aspirin	269-277	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	229-234
15163023-7	2004	COX-2 immunohistochemistry was performed using affinity purified polyclonal murine antibody and avidin-biotin detection method with citrate antigen retrieval.	avidin-biotin	96-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
15163023-7	2004	COX-2 immunohistochemistry was performed using affinity purified polyclonal murine antibody and avidin-biotin detection method with citrate antigen retrieval.	Citric Acid	132-139	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
14988266-10	2004	These results show that high glucose and diabetes can augment inflammatory responses by upregulating COX-2 via multiple signaling pathways, leading to monocyte activation relevant to the pathogenesis of diabetes complications.	Glucose	29-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-106
14732722-3	2004	COX-2 metabolites have been implicated in maintenance of renal blood flow, mediation of renin release, and regulation of sodium excretion.	Sodium	121-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
14732722-4	2004	COX-2 inhibition may transiently decrease urine sodium excretion in some subjects and induce mild to moderate elevation of blood pressure.	Sodium	48-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
15311968-5	2004	Ginger extract-HAPC (100 microg/ml) significantly inhibited the activation of TNF-alpha and COX-2 expression in human synoviocytes as well as suppressed production of TNF-alpha and PGE-2.	hapc	15-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-97
14712483-6	2004	Significant suppression of cellular proliferation was demonstrated in OS-RC-2 antisense transfectants, whereas promotion was found in SMKT-R4 sense transfectants by colony-forming assay despite the observation that COX-2 specific inhibitor NS398 exhibited similar IC50 among RCC cell lines by MTT assay.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	240-245	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	215-220
15117090-1	2004	This randomised, double-blind, placebo-controlled, parallel-group study compared the efficacy and tolerability of lumiracoxib (a novel COX-2 selective inhibitor) with rofecoxib, celecoxib and placebo in patients with moderate-to-severe post-operative dental pain.	lumiracoxib	114-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-140
14762933-6	2004	Exposure of human macrophages to mechanical stretch with particles upregulated the expression of cyclooxygenase (COX)-2 mRNA but not COX-1 mRNA, this expression resulting in a 97-fold increase in PGE(2) production compared to the nonstimulated cells.	Prostaglandins E	196-199	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-119
14991771-3	2004	bFGF reduced apoptosis in MCF-7 breast cancer cells and up-regulated the expression of mitocondrial Bcl-2, whereas COX inhibitors meloxicam (selective COX-2) and aspirin (non-selective), induced apoptosis.	Meloxicam	130-139	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-156
15039937-1	2004	Valdecoxib is a potent COX-2 inhibitor.	valdecoxib	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-28
14711936-4	2004	Here, we report that celecoxib, one of the new class of selective COX-2 inhibitors, has the potential to reverse tumor-mediated wasting and associated humoral factors such as interleukin (IL)-6 and hypercalcemia in preclinical models of cachexia.	Celecoxib	21-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-71
15026550-2	2004	This study was designed to evaluate the effect and mechanisms of the selective COX-2 inhibitor celecoxib in the growth control of human cholangiocarcinoma cells.	Celecoxib	95-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-84
15026550-3	2004	Immunohistochemical analysis using human cholangiocarcinoma tissues showed increased levels of COX-2 as well as phospho-Akt (Thr (308)), a protein kinase activated by COX-2-mediated prostaglandins, in human cholangiocarcinoma cells.	Threonine	125-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	167-172
15026550-3	2004	Immunohistochemical analysis using human cholangiocarcinoma tissues showed increased levels of COX-2 as well as phospho-Akt (Thr (308)), a protein kinase activated by COX-2-mediated prostaglandins, in human cholangiocarcinoma cells.	Prostaglandins	182-196	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	167-172
14987993-0	2004	PI 3-kinase and MAP kinase regulate bradykinin induced prostaglandin E(2) release in human pulmonary artery by modulating COX-2 activity.	Dinoprostone	55-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-127
14987993-4	2004	The inhibitory mechanism used by LY294002 did not involve cytosolic PLA(2) activation or COX-1, COX-2 and PGES protein expression but rather a novel effect on COX enzymatic activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-101
14765218-1	2004	Co(II) sulfate reacts with the flexible ligand 1,4-bis(imidazol-1-ylmethyl)benzene (bix) to yield the coordination network [Co(bix)2(H2O)2](SO4).7H2O, containing polymeric ribbons of rings which penetrate and catenate a 3D single frame of the CdSO4 topology, to produce an open-channel entangled architecture with nanoporous behaviour.	1,4-Bis((1H-imidazol-1-yl)methyl)benzene	47-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
14765218-1	2004	Co(II) sulfate reacts with the flexible ligand 1,4-bis(imidazol-1-ylmethyl)benzene (bix) to yield the coordination network [Co(bix)2(H2O)2](SO4).7H2O, containing polymeric ribbons of rings which penetrate and catenate a 3D single frame of the CdSO4 topology, to produce an open-channel entangled architecture with nanoporous behaviour.	2-(3,4-dihydroxyphenyl)-2-oxoethyl thiocyanate	84-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
14765218-1	2004	Co(II) sulfate reacts with the flexible ligand 1,4-bis(imidazol-1-ylmethyl)benzene (bix) to yield the coordination network [Co(bix)2(H2O)2](SO4).7H2O, containing polymeric ribbons of rings which penetrate and catenate a 3D single frame of the CdSO4 topology, to produce an open-channel entangled architecture with nanoporous behaviour.	co(bix)2(h2o)2]	124-139	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
14765218-1	2004	Co(II) sulfate reacts with the flexible ligand 1,4-bis(imidazol-1-ylmethyl)benzene (bix) to yield the coordination network [Co(bix)2(H2O)2](SO4).7H2O, containing polymeric ribbons of rings which penetrate and catenate a 3D single frame of the CdSO4 topology, to produce an open-channel entangled architecture with nanoporous behaviour.	so4).7h2o	140-149	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
14765218-1	2004	Co(II) sulfate reacts with the flexible ligand 1,4-bis(imidazol-1-ylmethyl)benzene (bix) to yield the coordination network [Co(bix)2(H2O)2](SO4).7H2O, containing polymeric ribbons of rings which penetrate and catenate a 3D single frame of the CdSO4 topology, to produce an open-channel entangled architecture with nanoporous behaviour.	cadmium sulfate	243-248	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
14971950-1	2004	A high-spin Co(II) complex (3d(7), S = 3/2), Co(PPh(3))(2)Cl(2) (Ph = phenyl), has been investigated in the solid state by both high-frequency and -field electron paramagnetic resonance (HFEPR) and by variable-temperature, variable-field magnetic circular dichroism (VTVH-MCD).	co(pph(3))(2)cl	45-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-17
15013005-2	2004	The interactions of the active S-isomer of the acid were theoretically compared with those of S-ibuprofen through molecular docking studies using COX-1 and COX-2 protein structures.	Ibuprofen	94-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	156-161
14670842-6	2004	The effect of IL-1beta, BK, and TGF-beta1 on cAMP levels was abrogated by the selective COX-2 inhibitor NS398.	Cyclic AMP	45-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-93
14670842-6	2004	The effect of IL-1beta, BK, and TGF-beta1 on cAMP levels was abrogated by the selective COX-2 inhibitor NS398.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	104-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-93
14670842-7	2004	Furthermore, it was mimicked by prolonged incubation with the COX-2 product PGE2 and PGI2 analogues or the COX substrate arachidonic acid, suggesting that it was mediated by endogenous prostanoids produced by COX-2.	Dinoprostone	76-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
14670842-7	2004	Furthermore, it was mimicked by prolonged incubation with the COX-2 product PGE2 and PGI2 analogues or the COX substrate arachidonic acid, suggesting that it was mediated by endogenous prostanoids produced by COX-2.	Dinoprostone	76-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	209-214
14670842-7	2004	Furthermore, it was mimicked by prolonged incubation with the COX-2 product PGE2 and PGI2 analogues or the COX substrate arachidonic acid, suggesting that it was mediated by endogenous prostanoids produced by COX-2.	Epoprostenol	85-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
14670842-7	2004	Furthermore, it was mimicked by prolonged incubation with the COX-2 product PGE2 and PGI2 analogues or the COX substrate arachidonic acid, suggesting that it was mediated by endogenous prostanoids produced by COX-2.	Epoprostenol	85-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	209-214
14670842-7	2004	Furthermore, it was mimicked by prolonged incubation with the COX-2 product PGE2 and PGI2 analogues or the COX substrate arachidonic acid, suggesting that it was mediated by endogenous prostanoids produced by COX-2.	Arachidonic Acid	121-137	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	209-214
14670842-7	2004	Furthermore, it was mimicked by prolonged incubation with the COX-2 product PGE2 and PGI2 analogues or the COX substrate arachidonic acid, suggesting that it was mediated by endogenous prostanoids produced by COX-2.	Prostaglandins	185-196	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
14670842-7	2004	Furthermore, it was mimicked by prolonged incubation with the COX-2 product PGE2 and PGI2 analogues or the COX substrate arachidonic acid, suggesting that it was mediated by endogenous prostanoids produced by COX-2.	Prostaglandins	185-196	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	209-214
14751245-1	2004	Prostaglandin E(2) (PGE(2)), a major cyclooxygenase (COX-2) metabolite, plays important roles in tumor biology and its functions are mediated through one or more of its receptors EP1, EP2, EP3, and EP4.	Dinoprostone	0-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-58
14751245-1	2004	Prostaglandin E(2) (PGE(2)), a major cyclooxygenase (COX-2) metabolite, plays important roles in tumor biology and its functions are mediated through one or more of its receptors EP1, EP2, EP3, and EP4.	Prostaglandins E	20-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-58
14966110-3	2004	Sequence analysis revealed two potential c-Ets binding sites in the COX-2 promoter (COX-2p) which bind to immunoreactive PU.1.	Cephalothin	41-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-90
14975457-2	2004	Aspirin and older agents in this class are nonselective inhibitors of both COX-1 and COX-2.	Aspirin	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-90
14975458-10	2004	In contrast, prostacyclin generation is both COX-1 and COX-2 dependent.	Epoprostenol	13-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-60
14764680-4	2004	CD40 ligation of monocytes induced the synthesis of a significant amount of PGE(2) via inducible expression of the cyclooxygenase (COX)-2 gene.	Prostaglandins E	76-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-137
14977856-1	2004	PURPOSE: The objectives of this study were to evaluate the effect of a cyclooxygenase (COX)-2 inhibitor, nimesulide, on the growth inhibition of s.c. human lung A549 adenocarcinoma tumors and to assess the effect of nimesulide on the expression of COX-2 and peroxisome proliferator-activated receptor (PPAR)-gamma in lung tumors harvested from mice.	nimesulide	105-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-93
14977856-1	2004	PURPOSE: The objectives of this study were to evaluate the effect of a cyclooxygenase (COX)-2 inhibitor, nimesulide, on the growth inhibition of s.c. human lung A549 adenocarcinoma tumors and to assess the effect of nimesulide on the expression of COX-2 and peroxisome proliferator-activated receptor (PPAR)-gamma in lung tumors harvested from mice.	nimesulide	105-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	248-253
14696113-4	2004	PD98059, a specific ERK1/2 inhibitor, inhibited EGF-induced proliferation with concomitant decreases in ERK1/2 phosphorylation and COX-2/PGE(2) induction.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-136
14696113-7	2004	This suggests that COX-2/PGE(2) activation involves in EGF-induced proliferation and locates at the downstream of ERK1/2 activation.	Prostaglandins E	25-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-24
14696113-8	2004	Furthermore, the natural product, 3-OH flavone, showed the most-potent inhibitory activity on EGF-induced proliferation among 9 structurally-related compounds, and suppression of EGF receptor phosphorylation, ERK1/2 phosphorylation, and COX-2/PGE(2) production by 3-OH flavone was identified.	3-oh flavone	34-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	237-242
14753813-0	2004	Coordination polymers assembled from angular dipyridyl ligands and CuII, CdII, CoII salts: crystal structures and properties.	Polymers	13-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-83
14753813-1	2004	Six new metal-organic coordination networks based on linking unit 2,5-bis(4-pyridyl)-1,3,4-thiadiazole (L(1)) or 2,5-bis(3-pyridyl)-1,3,4-oxadiazole (L(3)) and inorganic Cu(II), Cd(II), and Co(II) salts have been prepared and structurally characterized by single-crystal X-ray analysis.	Metals	8-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	190-196
15252555-1	2004	Dioxygen uptake by their dinuclear Co(II) complexes.	Oxygen	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-41
15252555-2	2004	The coordination properties of the ditopic oxa-aza macrocycles L1-L3 toward Ni(II) and Co(II) have been investigated by means of potentiometric and UV-vis spectrophotometric measurements.	oxa-aza	43-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-93
15252555-6	2004	Under aerobic conditions the binuclear Co(II) complexes of the ligands L1-L3 are able to bind molecular oxygen, with a bridging coordination of O2 between the two metals.	Oxygen	104-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-45
15252555-6	2004	Under aerobic conditions the binuclear Co(II) complexes of the ligands L1-L3 are able to bind molecular oxygen, with a bridging coordination of O2 between the two metals.	Oxygen	144-146	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-45
14725573-4	2004	In 2003, the results of studies suggest, and guidelines recommend, the careful selection of anti-inflammatory drugs - NSAIDs or selective COX-2 inhibitors (coxibs) based upon patients gastrointestinal history and use of aspirin therapy.	Aspirin	220-227	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	138-143
14742249-9	2004	Treatment of PC-3 cells with a COX-1 selective inhibitor, piroxicam, reduced TXA(2) synthesis by approximately 40%, while the COX-2 specific inhibitor NS398 reduced TXA(2) production by approximately 80%.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	151-156	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-131
14764122-1	2004	OBJECTIVES: To evaluate the efficacy of the cyclooxygenase (COX)-2 inhibitor celecoxib in prostate-specific antigen (PSA) recurrent prostate cancer after definitive radiation therapy (RT) or radical prostatectomy (RP), as recent evidence showed that COX-2 inhibitors have potent antitumour activity in prostate cancer both in vitro and in vivo but there are no human trials.	Celecoxib	77-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-66
14592854-5	2004	Recent studies from our group suggest that variable expression of upstream and downstream enzymes in the prostanoid biosynthetic cascade may represent important determinants of the functional consequences of COX-2 expression and inhibition in different clinical settings.	Prostaglandins	105-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	208-213
14510637-3	2004	With the detergent genapol X-100 (2 mM) present, the potencies of nimesulide, ibuprofen, flufenamic acid, niflumic acid and naproxen were increased over 100-fold against Cox-2 and titration curve shapes changed, so that maximal inhibition now approached 100%.	Flufenamic Acid	89-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	170-175
14510637-3	2004	With the detergent genapol X-100 (2 mM) present, the potencies of nimesulide, ibuprofen, flufenamic acid, niflumic acid and naproxen were increased over 100-fold against Cox-2 and titration curve shapes changed, so that maximal inhibition now approached 100%.	Niflumic Acid	106-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	170-175
14510637-3	2004	With the detergent genapol X-100 (2 mM) present, the potencies of nimesulide, ibuprofen, flufenamic acid, niflumic acid and naproxen were increased over 100-fold against Cox-2 and titration curve shapes changed, so that maximal inhibition now approached 100%.	Naproxen	124-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	170-175
14510637-6	2004	DuP-697 and two analogues became more than 10-fold less potent against Cox-2 with genapol present.	genapol	82-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-76
14510637-9	2004	The increases in potency of ibuprofen, flufenamic acid, isoxicam and niflumic acid towards Cox-2 and ibuprofen towards Cox-1 were accompanied by a change from time-independent to time-dependent inhibition.	Ibuprofen	28-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-96
14510637-9	2004	The increases in potency of ibuprofen, flufenamic acid, isoxicam and niflumic acid towards Cox-2 and ibuprofen towards Cox-1 were accompanied by a change from time-independent to time-dependent inhibition.	Flufenamic Acid	39-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-96
14510637-9	2004	The increases in potency of ibuprofen, flufenamic acid, isoxicam and niflumic acid towards Cox-2 and ibuprofen towards Cox-1 were accompanied by a change from time-independent to time-dependent inhibition.	isoxicam	56-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-96
14510637-9	2004	The increases in potency of ibuprofen, flufenamic acid, isoxicam and niflumic acid towards Cox-2 and ibuprofen towards Cox-1 were accompanied by a change from time-independent to time-dependent inhibition.	Niflumic Acid	69-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-96
14510637-3	2004	With the detergent genapol X-100 (2 mM) present, the potencies of nimesulide, ibuprofen, flufenamic acid, niflumic acid and naproxen were increased over 100-fold against Cox-2 and titration curve shapes changed, so that maximal inhibition now approached 100%.	genapol x-100	19-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	170-175
14510637-3	2004	With the detergent genapol X-100 (2 mM) present, the potencies of nimesulide, ibuprofen, flufenamic acid, niflumic acid and naproxen were increased over 100-fold against Cox-2 and titration curve shapes changed, so that maximal inhibition now approached 100%.	nimesulide	66-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	170-175
14510637-3	2004	With the detergent genapol X-100 (2 mM) present, the potencies of nimesulide, ibuprofen, flufenamic acid, niflumic acid and naproxen were increased over 100-fold against Cox-2 and titration curve shapes changed, so that maximal inhibition now approached 100%.	Ibuprofen	78-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	170-175
14748725-5	2004	Studies with the COX-2-selective inhibitor NS-398 confirmed the COX-2 dependency of the later increase in prostanoid production.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	43-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22
14748725-5	2004	Studies with the COX-2-selective inhibitor NS-398 confirmed the COX-2 dependency of the later increase in prostanoid production.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	43-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-69
14748725-5	2004	Studies with the COX-2-selective inhibitor NS-398 confirmed the COX-2 dependency of the later increase in prostanoid production.	Prostaglandins	106-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22
14748725-5	2004	Studies with the COX-2-selective inhibitor NS-398 confirmed the COX-2 dependency of the later increase in prostanoid production.	Prostaglandins	106-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-69
14604894-2	2004	In this study, 250 lung cancer patients and 214 controls were genotyped for polymorphisms of the inflammation-related genes prostaglandin synthase-2/cyclooxygenase-2 (COX2/PTGS2), interleukin-6 (IL6), interleukin-8 (IL8) and peroxisome proliferator-activated receptor gamma (PPARg).	Prostaglandins	124-137	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	167-171
15037209-7	2004	Interestingly, a combination of the oral administration of each of all selective COX-2 inhibitors except rofecoxib with the intravenous administration of indomethacin clearly produced gastric lesions.	Indomethacin	154-166	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-86
14749287-0	2004	Glucose-induced regulation of COX-2 expression in human islets of Langerhans.	Glucose	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-35
15017615-4	2004	At the start and end of each dosing period, COX-2 selectivity was assessed by ex vivo serum thromboxane B(2) (COX-1) and lipopolysaccharide stimulated prostaglandin (PG) E(2) (COX-2), mucosal injury by endoscopy, and small and large bowel permeability by 0- to 5-hour and 5- to 24-hour (51)Cr-EDTA absorption.	Thromboxane B2	92-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-49
15017615-4	2004	At the start and end of each dosing period, COX-2 selectivity was assessed by ex vivo serum thromboxane B(2) (COX-1) and lipopolysaccharide stimulated prostaglandin (PG) E(2) (COX-2), mucosal injury by endoscopy, and small and large bowel permeability by 0- to 5-hour and 5- to 24-hour (51)Cr-EDTA absorption.	Dinoprostone	151-174	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-49
15017615-4	2004	At the start and end of each dosing period, COX-2 selectivity was assessed by ex vivo serum thromboxane B(2) (COX-1) and lipopolysaccharide stimulated prostaglandin (PG) E(2) (COX-2), mucosal injury by endoscopy, and small and large bowel permeability by 0- to 5-hour and 5- to 24-hour (51)Cr-EDTA absorption.	cr-edta	290-297	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-49
15017615-10	2004	CONCLUSIONS: Lumiracoxib is a potent selective inhibitor of COX-2 that causes little or no endoscopically detected stomach or duodenal injury or changes in bowel permeability.	lumiracoxib	13-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-65
15023244-1	2004	Cyclooxygenase (COX)-2, an inducible isoform of cyclooxygenases, regulates the rapid production of high levels of prostaglandins during inflammation.	Prostaglandins	114-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-22
14749287-7	2004	Given that hyperglycemia has been reported to increase human beta-cell production of interleukin-1beta and that this cytokine can induce COX-2 expression, our observations of glucose-induced induction of COX-2 in human islets suggest that this is one route through which hyperglycemia may contribute to beta-cell dysfunction.	Glucose	175-182	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-142
14749287-7	2004	Given that hyperglycemia has been reported to increase human beta-cell production of interleukin-1beta and that this cytokine can induce COX-2 expression, our observations of glucose-induced induction of COX-2 in human islets suggest that this is one route through which hyperglycemia may contribute to beta-cell dysfunction.	Glucose	175-182	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	204-209
14713756-7	2004	Selective COX-2 inhibitors are currently under study to evaluate their potential roles in preventing prostate cancer in high-risk patients (rofecoxib) or the recurrence of bladder cancer (celecoxib).	rofecoxib	140-149	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
14984594-6	2004	COX-2 expression was accompanied by DC synthesis of PGE2, with peak levels present at 6-18 h post-stimulation.	Dinoprostone	52-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
14984594-8	2004	When DC were activated with LPS in the presence of nimesulide, a COX-2 selective inhibitor, IL-10 synthesis was inhibited, indicating that endogenous prostaglandins regulate DC cytokine production.	nimesulide	51-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-70
14984594-8	2004	When DC were activated with LPS in the presence of nimesulide, a COX-2 selective inhibitor, IL-10 synthesis was inhibited, indicating that endogenous prostaglandins regulate DC cytokine production.	Prostaglandins	150-164	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-70
14747429-1	2004	This two-way crossover study evaluated the effect of fluconazole on the pharmacokinetics and selective COX-2 inhibition of lumiracoxib.	lumiracoxib	123-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-108
14991374-0	2004	COX-2 inhibition as a treatment approach in schizophrenia: immunological considerations and clinical effects of celecoxib add-on therapy.	Celecoxib	112-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
14673644-8	2004	We have also examined the DNA sequence of prostaglandin-endoperoxide synthase 2 (PTGS2 or cyclooxygenase 2, COX2) since prostaglandin 2 (PGE2), the product of COX2, is upregulated in LAP patients and COX2 is located between D1S196 and D1S533.	(5Z,13E,15S)-15-hydroxy-9-oxoprosta-5,10,13-trien-1-oate	120-135	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	159-163
14673644-8	2004	We have also examined the DNA sequence of prostaglandin-endoperoxide synthase 2 (PTGS2 or cyclooxygenase 2, COX2) since prostaglandin 2 (PGE2), the product of COX2, is upregulated in LAP patients and COX2 is located between D1S196 and D1S533.	(5Z,13E,15S)-15-hydroxy-9-oxoprosta-5,10,13-trien-1-oate	120-135	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	159-163
14760808-12	2004	Among the COX-2-specific inhibitors, celecoxib has a longer survival time than rofecoxib.	Celecoxib	37-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
14760808-12	2004	Among the COX-2-specific inhibitors, celecoxib has a longer survival time than rofecoxib.	rofecoxib	79-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
14713756-7	2004	Selective COX-2 inhibitors are currently under study to evaluate their potential roles in preventing prostate cancer in high-risk patients (rofecoxib) or the recurrence of bladder cancer (celecoxib).	Celecoxib	188-197	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
15061569-14	2004	ASA inhibits COX-1 and converts COX-2 into an ASA-triggered lipid mediator-generating system that produces an array of novel endogenous local autacoids from dietary omega-3 PUFA.	Aspirin	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-37
14742690-0	2004	Aspirin-mediated COX-2 transcript stabilization via sustained p38 activation in human intestinal myofibroblasts.	Aspirin	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22
14742690-2	2004	In human intestinal myofibroblasts, aspirin, at therapeutic doses, had the unexpected effect of inducing prolonged COX-2 expression.	Aspirin	36-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-120
14742690-3	2004	This induction was especially pronounced when cells were treated with interleukin-1alpha (IL-1) plus aspirin for 24 h. Sodium salicylate, a poor COX inhibitor, likewise enhanced IL-1-mediated COX-2 gene expression whereas 5-aminosalicylic acid (5-ASA) or indomethacin had no effect.	Aspirin	101-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	192-197
14742690-3	2004	This induction was especially pronounced when cells were treated with interleukin-1alpha (IL-1) plus aspirin for 24 h. Sodium salicylate, a poor COX inhibitor, likewise enhanced IL-1-mediated COX-2 gene expression whereas 5-aminosalicylic acid (5-ASA) or indomethacin had no effect.	Sodium Salicylate	119-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	192-197
14742690-4	2004	The COX-2 transcriptional rate, measured by nuclear runoff analysis and heterogeneous nuclear RNA reverse transcription-polymerase chain reaction, was only modestly elevated by aspirin treatment.	Aspirin	177-184	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
14742690-5	2004	In contrast, aspirin treatment dramatically stabilized the COX-2 message.	Aspirin	13-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-64
14742690-6	2004	The COX-2 mRNA half-life in IL-1 treated cells was 1 h and was increased in excess of 5 h in IL-1 + aspirin-treated cells.	Aspirin	100-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
14742690-8	2004	Inhibition of p38 activity negated aspirin-mediated COX-2 mRNA stabilization and the resultant increase in COX-2 mRNA and protein levels.	Aspirin	35-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-57
14742690-10	2004	We conclude that aspirin enhances COX-2 expression via sustained activation of p38, which results in prolonged stabilization of the COX-2 message and a slightly elevated transcription rate.	Aspirin	17-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-39
14742690-10	2004	We conclude that aspirin enhances COX-2 expression via sustained activation of p38, which results in prolonged stabilization of the COX-2 message and a slightly elevated transcription rate.	Aspirin	17-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-137
15070163-7	2004	Our results indicate that Salix extract 1520L inhibits COX-2-mediated PGE2 release through compounds other than salicin or salicylate.	Dinoprostone	70-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-60
15070163-7	2004	Our results indicate that Salix extract 1520L inhibits COX-2-mediated PGE2 release through compounds other than salicin or salicylate.	salicin	112-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-60
14648334-7	2004	More recently, the use of nimesulide, a selective COX-2 inhibitor, as a tocolytic agent has been advocated.	nimesulide	26-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-55
14752171-3	2004	Cyclooxygenase (COX)-1 and COX-2 are responsible for the production of PGs.	Prostaglandins	71-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-32
14752171-4	2004	Inhibition of these enzymes by non-steroidal anti-inflammatory drugs and selective COX-2 inhibitors reduces the levels of PGs, resulting in a reduction in pain and inflammation.	Prostaglandins	122-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
14698154-3	2004	Sulpiride shows CA inhibitory properties of the same magnitude as dichlorophenamide, a clinically used antiglaucoma sulfonamide, or valdecoxib, a COX-2 selective inhibitor recently shown to inhibit CA.	Sulpiride	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	146-151
14752171-6	2004	Licofelone is a competitive inhibitor of 5-LOX, COX-1 and COX-2 that is currently being developed for the treatment of osteoarthritis.	licofelone	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
14752172-1	2004	Licofelone, a competitive inhibitor of 5-lipoxygenase, cyclooxygenase (COX)-1 and COX-2, is currently in clinical development for the treatment of osteoarthritis (OA).	licofelone	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
14731007-1	2004	The synthesis, structure elucidation, and analysis of the self-assembly of Co(II) complexes of 3,5-dinitrobenzoic acid and 3,5-dinitro-4-methylbenzoic acid with 4,4"-bipyridine have been reported.	3,5-dinitrobenzoic acid	95-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-81
14731007-1	2004	The synthesis, structure elucidation, and analysis of the self-assembly of Co(II) complexes of 3,5-dinitrobenzoic acid and 3,5-dinitro-4-methylbenzoic acid with 4,4"-bipyridine have been reported.	4-Methyl-3,5-dinitrobenzoic acid	123-155	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-81
14731007-1	2004	The synthesis, structure elucidation, and analysis of the self-assembly of Co(II) complexes of 3,5-dinitrobenzoic acid and 3,5-dinitro-4-methylbenzoic acid with 4,4"-bipyridine have been reported.	4,4'-bipyridyl	161-176	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-81
14731007-10	2004	In all the complexes 1a, 1b, 2a, and 2b, the basic interaction between Co(II) and 4,4"-bipyridine remains the same with the formation of linear Co-N dative bonds, but the carboxylates display various modes of interaction with Co(II).	4,4'-bipyridyl	82-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-77
14731007-10	2004	In all the complexes 1a, 1b, 2a, and 2b, the basic interaction between Co(II) and 4,4"-bipyridine remains the same with the formation of linear Co-N dative bonds, but the carboxylates display various modes of interaction with Co(II).	co-n	144-148	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-77
15356722-7	2004	In both Ni(II) and Co(II) complexes the metal ion oxidation in the presence of oxygen and sulfite involves the reduction of some initial Ni(III) or Co(III) by sulfite to produce the SO(3).- radical, which rapidly reacts with dissolved oxygen to produce SO(5).-, which then oxidizes Ni(II) or Co(II).	Metals	40-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	292-298
15356722-7	2004	In both Ni(II) and Co(II) complexes the metal ion oxidation in the presence of oxygen and sulfite involves the reduction of some initial Ni(III) or Co(III) by sulfite to produce the SO(3).- radical, which rapidly reacts with dissolved oxygen to produce SO(5).-, which then oxidizes Ni(II) or Co(II).	Oxygen	79-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-25
15356722-7	2004	In both Ni(II) and Co(II) complexes the metal ion oxidation in the presence of oxygen and sulfite involves the reduction of some initial Ni(III) or Co(III) by sulfite to produce the SO(3).- radical, which rapidly reacts with dissolved oxygen to produce SO(5).-, which then oxidizes Ni(II) or Co(II).	Oxygen	79-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	292-298
15356722-7	2004	In both Ni(II) and Co(II) complexes the metal ion oxidation in the presence of oxygen and sulfite involves the reduction of some initial Ni(III) or Co(III) by sulfite to produce the SO(3).- radical, which rapidly reacts with dissolved oxygen to produce SO(5).-, which then oxidizes Ni(II) or Co(II).	Sulfites	90-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-25
15356722-7	2004	In both Ni(II) and Co(II) complexes the metal ion oxidation in the presence of oxygen and sulfite involves the reduction of some initial Ni(III) or Co(III) by sulfite to produce the SO(3).- radical, which rapidly reacts with dissolved oxygen to produce SO(5).-, which then oxidizes Ni(II) or Co(II).	Sulfites	90-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	292-298
15356722-7	2004	In both Ni(II) and Co(II) complexes the metal ion oxidation in the presence of oxygen and sulfite involves the reduction of some initial Ni(III) or Co(III) by sulfite to produce the SO(3).- radical, which rapidly reacts with dissolved oxygen to produce SO(5).-, which then oxidizes Ni(II) or Co(II).	Sulfites	159-166	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-25
15356722-7	2004	In both Ni(II) and Co(II) complexes the metal ion oxidation in the presence of oxygen and sulfite involves the reduction of some initial Ni(III) or Co(III) by sulfite to produce the SO(3).- radical, which rapidly reacts with dissolved oxygen to produce SO(5).-, which then oxidizes Ni(II) or Co(II).	Sulfites	159-166	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	292-298
15356722-7	2004	In both Ni(II) and Co(II) complexes the metal ion oxidation in the presence of oxygen and sulfite involves the reduction of some initial Ni(III) or Co(III) by sulfite to produce the SO(3).- radical, which rapidly reacts with dissolved oxygen to produce SO(5).-, which then oxidizes Ni(II) or Co(II).	sulfur trioxide	182-189	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-25
15356722-7	2004	In both Ni(II) and Co(II) complexes the metal ion oxidation in the presence of oxygen and sulfite involves the reduction of some initial Ni(III) or Co(III) by sulfite to produce the SO(3).- radical, which rapidly reacts with dissolved oxygen to produce SO(5).-, which then oxidizes Ni(II) or Co(II).	sulfur trioxide	182-189	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	292-298
15356722-7	2004	In both Ni(II) and Co(II) complexes the metal ion oxidation in the presence of oxygen and sulfite involves the reduction of some initial Ni(III) or Co(III) by sulfite to produce the SO(3).- radical, which rapidly reacts with dissolved oxygen to produce SO(5).-, which then oxidizes Ni(II) or Co(II).	Oxygen	235-241	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-25
15356722-7	2004	In both Ni(II) and Co(II) complexes the metal ion oxidation in the presence of oxygen and sulfite involves the reduction of some initial Ni(III) or Co(III) by sulfite to produce the SO(3).- radical, which rapidly reacts with dissolved oxygen to produce SO(5).-, which then oxidizes Ni(II) or Co(II).	Nickel(2+)	282-288	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-25
15356721-9	2004	It consists of dimeric Co(II)(phen) units, doubly bridged by carboxylate groups in a distorted syn-syn fashion.	1,10-phenanthroline	30-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-29
15356722-2	2004	The oxidation of Ni(II) and Co(II) tetraglycine complexes in borate buffer aqueous solution, by dissolved oxygen, is strongly accelerated by sulfite.	Oxygen	106-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-34
15356722-2	2004	The oxidation of Ni(II) and Co(II) tetraglycine complexes in borate buffer aqueous solution, by dissolved oxygen, is strongly accelerated by sulfite.	Sulfites	141-148	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-34
15356722-6	2004	The electrochemical process related to the couple Co(II)/Co(III), in a medium containing tetraglycine, was not reversible.	glycyl-glycyl-glycyl-glycine	89-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-56
15356722-7	2004	In both Ni(II) and Co(II) complexes the metal ion oxidation in the presence of oxygen and sulfite involves the reduction of some initial Ni(III) or Co(III) by sulfite to produce the SO(3).- radical, which rapidly reacts with dissolved oxygen to produce SO(5).-, which then oxidizes Ni(II) or Co(II).	Nickel(2+)	8-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	292-298
15356722-7	2004	In both Ni(II) and Co(II) complexes the metal ion oxidation in the presence of oxygen and sulfite involves the reduction of some initial Ni(III) or Co(III) by sulfite to produce the SO(3).- radical, which rapidly reacts with dissolved oxygen to produce SO(5).-, which then oxidizes Ni(II) or Co(II).	Metals	40-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-25
14698178-1	2004	Novel 1,2-diaryl-1-ethanone 1 and pyrazolo [4,3-c] quinoline-4-one 2, with pharmacophores different from the known COX inhibitors were identified as selective COX-2 inhibitors.	1,2-diaryl-1-ethanone	6-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	159-164
14698178-1	2004	Novel 1,2-diaryl-1-ethanone 1 and pyrazolo [4,3-c] quinoline-4-one 2, with pharmacophores different from the known COX inhibitors were identified as selective COX-2 inhibitors.	pyrazolo [4,3-c] quinoline-4-one	34-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	159-164
14698190-0	2004	Polar substitutions in the benzenesulfonamide ring of celecoxib afford a potent 1,5-diarylpyrazole class of COX-2 inhibitors.	benzenesulfonamide	27-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-113
14698190-0	2004	Polar substitutions in the benzenesulfonamide ring of celecoxib afford a potent 1,5-diarylpyrazole class of COX-2 inhibitors.	Celecoxib	54-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-113
14698190-0	2004	Polar substitutions in the benzenesulfonamide ring of celecoxib afford a potent 1,5-diarylpyrazole class of COX-2 inhibitors.	1,5-diarylpyrazole	80-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-113
14698190-2	2004	The series with a hydroxymethyl group adjacent to the sulfonamide was found to be the most potent modification that yielded many compounds selectively active against COX-2 enzyme in vitro.	Sulfonamides	54-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	166-171
14698154-3	2004	Sulpiride shows CA inhibitory properties of the same magnitude as dichlorophenamide, a clinically used antiglaucoma sulfonamide, or valdecoxib, a COX-2 selective inhibitor recently shown to inhibit CA.	valdecoxib	132-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	146-151
14744769-5	2004	We developed an isopropyl-beta-D-thiogalactopyranoside-inducible COX-2 gene expression system in human lung adenocarcinoma CL1.0 cells.	Isopropyl Thiogalactoside	16-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-70
16146090-0	2004	Effect of nimesulide-a preferential COX-2 inhibitor on arterial blood pressure, compared to ketoprofen.	nimesulide	10-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-41
14737327-1	2004	Hydrophobic vitamin B(12) was covalently immobilized onto a platinum electrode surface, and the immobilized complex exhibits Co(ii)/Co(i) redox couple and in situ the Co(i) species reacts with phenethyl bromide to form styrene under irradiation with visible light with a turnover number of over 6000 for 1 h.	Vitamin B 12	12-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-131
14737327-1	2004	Hydrophobic vitamin B(12) was covalently immobilized onto a platinum electrode surface, and the immobilized complex exhibits Co(ii)/Co(i) redox couple and in situ the Co(i) species reacts with phenethyl bromide to form styrene under irradiation with visible light with a turnover number of over 6000 for 1 h.	Platinum	60-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-131
14737327-1	2004	Hydrophobic vitamin B(12) was covalently immobilized onto a platinum electrode surface, and the immobilized complex exhibits Co(ii)/Co(i) redox couple and in situ the Co(i) species reacts with phenethyl bromide to form styrene under irradiation with visible light with a turnover number of over 6000 for 1 h.	Styrene	219-226	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-131
14715958-1	2004	The cyclooxygenases COX-1 and COX-2 catalyze the first committed step of prostaglandin synthesis from arachidonic acid.	Prostaglandins	73-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-35
14715958-1	2004	The cyclooxygenases COX-1 and COX-2 catalyze the first committed step of prostaglandin synthesis from arachidonic acid.	Arachidonic Acid	102-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-35
14715958-3	2004	We investigated the function of PGE2, a principal prostaglandin product of COX-2 enzymatic activity, in neuronal survival in cerebral ischemia.	Dinoprostone	32-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
14697046-3	2004	The latter reaction is based on the electroreduction of the Co(III) center in vitamin B12 to Co(I), which specifically reacts with DBCH to produce electrocatalytic currents with the regeneration of Co (II); a detection limit of 8.5 x 10(-10) mol dm(-3) (based on 3sigma) was found.	Vitamin B 12	78-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	198-205
14697046-3	2004	The latter reaction is based on the electroreduction of the Co(III) center in vitamin B12 to Co(I), which specifically reacts with DBCH to produce electrocatalytic currents with the regeneration of Co (II); a detection limit of 8.5 x 10(-10) mol dm(-3) (based on 3sigma) was found.	dbch	131-135	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	198-205
14697046-3	2004	The latter reaction is based on the electroreduction of the Co(III) center in vitamin B12 to Co(I), which specifically reacts with DBCH to produce electrocatalytic currents with the regeneration of Co (II); a detection limit of 8.5 x 10(-10) mol dm(-3) (based on 3sigma) was found.	dm	246-248	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	198-205
16146090-1	2004	Clinical and experimental studies have shown that renal and cardiovascular effects of most selective COX-2 inhibitors (rofecoxib, celecoxib) are similar to other traditional NSAIDs (dual COX inhibitors).	rofecoxib	119-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-106
16146090-1	2004	Clinical and experimental studies have shown that renal and cardiovascular effects of most selective COX-2 inhibitors (rofecoxib, celecoxib) are similar to other traditional NSAIDs (dual COX inhibitors).	Celecoxib	130-139	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-106
16146090-2	2004	In these study the effect of nimesulide--preferential COX-2 inhibitor, administration on 24-hour blood pressure profile was investigated in 40 adult individuals on antihypertensive therapy with pain states caused by osteoartritis.	nimesulide	29-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-59
14729623-3	2004	Other studies have shown that the COX-2 mRNA contains an adenine- and uridine-rich element and is stabilized by HuR.	Adenine	57-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-39
15142263-11	2004	Indomethacin increased IL-1beta-induced IL-1Ra secretion in synovial fibroblasts and de-differentiated chondrocytes, suggesting that inhibition of COX-2 may indeed enhance IL-1beta-induced IL-1Ra production.	Indomethacin	0-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-152
14726653-5	2004	In addition, although several different selective COX-2 inhibitors potently reduced PGE2 levels in these cells, none of them exerted anti-proliferative effects that were comparable to celecoxib.	Dinoprostone	84-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-55
14726653-8	2004	Taken together, our results show that celecoxib exerts COX-2-independent anti-proliferative effects on glioblastoma cell growth, which are more potent than those of other selective COX-2 inhibitors or traditional NSAIDs, and which are mediated via the transcriptional inhibition of two essential components of the cell cycle machinery, cyclin A and cyclin B.	Celecoxib	38-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-60
14729623-3	2004	Other studies have shown that the COX-2 mRNA contains an adenine- and uridine-rich element and is stabilized by HuR.	Uridine	70-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-39
14726653-8	2004	Taken together, our results show that celecoxib exerts COX-2-independent anti-proliferative effects on glioblastoma cell growth, which are more potent than those of other selective COX-2 inhibitors or traditional NSAIDs, and which are mediated via the transcriptional inhibition of two essential components of the cell cycle machinery, cyclin A and cyclin B.	Celecoxib	38-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	181-186
14996519-1	2004	BACKGROUND: Based on the experience with selective cyclooxygenase (COX)-2 inhibitors, including rofecoxib, valdecoxib, and celecoxib, it was anticipated that etoricoxib, a new selective COX-2 inhibitor, would display mechanism-based, dose-dependent renal adverse effects (AEs) similar to those observed with nonselective non-steroidal anti-inflammatory drugs (NSAIDs) in long-term treatment.	Etoricoxib	158-168	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-73
15068837-5	2004	Celecoxib is a potent COX-2 inhibitor being developed for the treatment of rheumatoid arthritis and osteoarthritis.	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-27
12956622-7	2004	Treatment with the COX-2 inhibitor suppressed the increase in urinary 15-keto-dihydro-PGF2alpha in the CLA 1012 group, but not in the CLA mix group.	Dhk-pgf2alpha	70-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-24
12956622-7	2004	Treatment with the COX-2 inhibitor suppressed the increase in urinary 15-keto-dihydro-PGF2alpha in the CLA 1012 group, but not in the CLA mix group.	Linoleic Acids, Conjugated	103-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-24
15199615-0	2004	COX-2 inhibitors as cancer treatment: will they be the new warfarin or trastuzumab?	Warfarin	59-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
17516707-3	2004	Lornoxicam is a strong analgesic and anti-inflammatory NSAID with balanced cyclo-oxygenase (COX)-1/COX-2 inhibition and excellent tolerability.	lornoxicam	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-104
17516707-6	2004	In the present study we investigated the treatment of patients with osteoarthritis with lornoxicam in comparison with treatment with the selective COX-2 inhibitor rofecoxib.	rofecoxib	163-172	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-152
12956622-7	2004	Treatment with the COX-2 inhibitor suppressed the increase in urinary 15-keto-dihydro-PGF2alpha in the CLA 1012 group, but not in the CLA mix group.	Linoleic Acids, Conjugated	134-137	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-24
14996519-1	2004	BACKGROUND: Based on the experience with selective cyclooxygenase (COX)-2 inhibitors, including rofecoxib, valdecoxib, and celecoxib, it was anticipated that etoricoxib, a new selective COX-2 inhibitor, would display mechanism-based, dose-dependent renal adverse effects (AEs) similar to those observed with nonselective non-steroidal anti-inflammatory drugs (NSAIDs) in long-term treatment.	Etoricoxib	158-168	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	186-191
12956622-9	2004	The CLA-induced production of PGF2alpha metabolites is probably partially mediated by COX-2.	Linoleic Acids, Conjugated	4-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-91
15383758-14	2004	The use of NSAIDS and aspirin, most likely via inhibition of COX-2 and other inflammatory pathways, is associated with a reduction of adenocarcinoma rates.	Aspirin	22-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-66
12956622-9	2004	The CLA-induced production of PGF2alpha metabolites is probably partially mediated by COX-2.	8-epi-prostaglandin F2alpha	30-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-91
14965321-1	2004	The cyclooxygenase isoenzymes, COX-1 and COX-2, catalyze the formation of prostaglandins, thromboxane, and levuloglandins.	Prostaglandins	74-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-46
14965321-1	2004	The cyclooxygenase isoenzymes, COX-1 and COX-2, catalyze the formation of prostaglandins, thromboxane, and levuloglandins.	Thromboxanes	90-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-46
14965321-1	2004	The cyclooxygenase isoenzymes, COX-1 and COX-2, catalyze the formation of prostaglandins, thromboxane, and levuloglandins.	levuloglandins	107-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-46
14965321-7	2004	During the past forty years systematic advances in our understanding of the structure, regulation and function of COX isoenzymes have enabled the design and synthesis of COX-2 selective inhibitors as agents intended to lessen the gastrointestinal irritation of aspirin and non-selective NSAIDs.	Aspirin	261-268	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	170-175
14965322-1	2004	Novel coxibs (i.e. etoricoxib, valdecoxib, parecoxib and lumiracoxib) with enhanced biochemical cyclooxygenase (COX)-2 selectivity over that of rofecoxib and celecoxib have been recently developed.	Etoricoxib	19-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-118
14965322-1	2004	Novel coxibs (i.e. etoricoxib, valdecoxib, parecoxib and lumiracoxib) with enhanced biochemical cyclooxygenase (COX)-2 selectivity over that of rofecoxib and celecoxib have been recently developed.	valdecoxib	31-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-118
14965322-1	2004	Novel coxibs (i.e. etoricoxib, valdecoxib, parecoxib and lumiracoxib) with enhanced biochemical cyclooxygenase (COX)-2 selectivity over that of rofecoxib and celecoxib have been recently developed.	parecoxib	43-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-118
14965322-1	2004	Novel coxibs (i.e. etoricoxib, valdecoxib, parecoxib and lumiracoxib) with enhanced biochemical cyclooxygenase (COX)-2 selectivity over that of rofecoxib and celecoxib have been recently developed.	lumiracoxib	57-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-118
14965322-6	2004	Etoricoxib shows only a slightly improved COX-2 selectivity than rofecoxib, a highly selective COX-2 inhibitor that has been reported to halve the incidence of serious gastrointestinal toxicity compared to nonselective nonsteroidal antiinflammatory drugs (NSAIDs).	Etoricoxib	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47
14965322-6	2004	Etoricoxib shows only a slightly improved COX-2 selectivity than rofecoxib, a highly selective COX-2 inhibitor that has been reported to halve the incidence of serious gastrointestinal toxicity compared to nonselective nonsteroidal antiinflammatory drugs (NSAIDs).	Etoricoxib	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-100
14965322-6	2004	Etoricoxib shows only a slightly improved COX-2 selectivity than rofecoxib, a highly selective COX-2 inhibitor that has been reported to halve the incidence of serious gastrointestinal toxicity compared to nonselective nonsteroidal antiinflammatory drugs (NSAIDs).	rofecoxib	65-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-100
14965322-7	2004	Lumiracoxib, the most selective COX-2 inhibitor in vitro, is the only acidic coxib.	lumiracoxib	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-37
14965323-9	2004	Selective COX-2 inhibitors were designed to inhibit the production of COX-2 dependent inflammatory prostanoids and to leave intact the cytoprotective COX-1 products.	Prostaglandins	99-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
14965323-9	2004	Selective COX-2 inhibitors were designed to inhibit the production of COX-2 dependent inflammatory prostanoids and to leave intact the cytoprotective COX-1 products.	Prostaglandins	99-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-75
14965324-2	2004	COX-2 supplanted the dominant oxygenase, the cytochrome P450 (CYP) enzyme, omega-hydroxylase, that synthesized 20-hydroxyeicosatetraenoic acid (20-HETE).	20-hydroxy-5,8,11,14-eicosatetraenoic acid	111-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
14965324-2	2004	COX-2 supplanted the dominant oxygenase, the cytochrome P450 (CYP) enzyme, omega-hydroxylase, that synthesized 20-hydroxyeicosatetraenoic acid (20-HETE).	20-hydroxy-5,8,11,14-eicosatetraenoic acid	144-151	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
14965324-4	2004	These studies of mTAL COX-2 expression which are addressed in the first part of this chapter are followed by explorations of the expression of COX-2 in preglomerular microvessels (PGMV) and the relationship of COX-2 to 20-HETE, the principal eicosanoid of PGMV.	pgmv	180-184	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	143-148
14965324-4	2004	These studies of mTAL COX-2 expression which are addressed in the first part of this chapter are followed by explorations of the expression of COX-2 in preglomerular microvessels (PGMV) and the relationship of COX-2 to 20-HETE, the principal eicosanoid of PGMV.	pgmv	180-184	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	143-148
15161329-1	2004	Valdecoxib is an orally administered, highly selective cyclo-oxygenase (COX)-2 inhibitor with anti-inflammatory and analgesic properties.	valdecoxib	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-78
15141994-7	2004	The specificity of etoricoxib for COX-2 has been found to be approximately 3-fold greater than that of rofecoxib and valdecoxib and approximately 14-fold more than celecoxib in human whole blood assays.	Etoricoxib	19-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-39
14756580-5	2004	This review focuses on the NSAID rofecoxib, one of the selective cyclo-oxygenase (COX)-2 inhibitors, which are claimed to be as effective as nonselective NSAIDs with better gastrointestinal tolerability.	rofecoxib	33-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-88
14756580-7	2004	In patients treated with low-dose aspirin (acetylsalicylic acid) for cardiovascular prophylaxis, celecoxib (another selective COX-2 inhibitor) seems to have no obvious advantages over conventional NSAIDs, and similar conclusions may be applied to rofecoxib.	Celecoxib	97-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-131
15161329-14	2004	In conclusion, valdecoxib, a COX-2-selective inhibitor, is as efficacious in pain relief as nonselective NSAIDs, with better gastrointestinal tolerability.	valdecoxib	15-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34
14699495-2	2004	The aim of this study is to determine how specific COX-2 inhibitor SC-236 mediates antitumor effect by modulation of AP-1-signaling pathway.	4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide	67-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-56
15456329-2	2004	Nabumetone itself is non-acidic and, following absorption, it undergoes extensive first-pass metabolism to form the main circulating active metabolite (6-MNA) which is a much more potent inhibitor of preferentially cyclo-oxygenase (COX)-2.	Nabumetone	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	215-238
15456329-15	2004	This has been attributed mainly to the non-acidic chemical properties of nabumetone but also to its COX-1/COX-2 inhibitor profile.	Nabumetone	73-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-111
15456339-1	2004	Lumiracoxib is a highly selective and potent cyclo-oxygenase (COX)-2 inhibitor, with a novel structure that conveys weakly acidic properties and a unique pharmacological profile.	lumiracoxib	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-68
15456339-4	2004	In single- and multiple-dose well designed trials in patients with acute pain associated with primary dysmenorrhoea, dental or orthopaedic surgery or tension-type headache, lumiracoxib 100-800 mg once daily was more effective in relieving acute pain than placebo or controlled-release oxycodone 20 mg, and was at least as effective as selective COX-2 inhibitors or nonselective NSAIDs.	lumiracoxib	173-184	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	345-350
15456339-5	2004	Lumiracoxib was generally well tolerated in clinical trials, with a similar overall tolerability profile to those of placebo and other COX-2-selective inhibitors.	lumiracoxib	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-140
15482000-9	2004	The COX-2 hypothesis proposes that aspirin causes a structural change in COX-2 that results in the generation of products of the lipoxygenase pathway.	Aspirin	35-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
15482000-9	2004	The COX-2 hypothesis proposes that aspirin causes a structural change in COX-2 that results in the generation of products of the lipoxygenase pathway.	Aspirin	35-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-78
15506544-3	2004	Ibuprofen, a commonly used over-the-counter nonsteroidal anti-inflammatory drug (NSAID) that is a cyclooxygenase (COX)-1 and COX-2 inhibitor as well as a peroxisome proliferator-activated receptor (PPAR) agonist, decreases the production of nitric oxide (NO), protects neurons against glutamate toxicity and decreases the production of proinflammatory cytokines.	Ibuprofen	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-130
14740745-6	2004	The addition of Ni(II), Co(II), and Zn(II) lowered the k(obs) for CT dechlorination, whereas the amendment of 0.5 mM Cu(II) into the Fe(II)-Fe(III) system significantly enhanced the efficiency and the rate of CT dechlorination.	ferric sulfate	140-147	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
14751313-0	2004	Synthesis and COX-2 inhibitory properties of N-phenyl- and N-benzyl-substituted amides of 2-(4-methylsulfonylphenyl)cyclopent-1-ene-1-carboxylic acid and of their pyrazole, thiophene and isoxazole analogs.	n-phenyl- and n-benzyl-substituted amides	45-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
14751313-0	2004	Synthesis and COX-2 inhibitory properties of N-phenyl- and N-benzyl-substituted amides of 2-(4-methylsulfonylphenyl)cyclopent-1-ene-1-carboxylic acid and of their pyrazole, thiophene and isoxazole analogs.	2-(4-methylsulfonylphenyl)cyclopent-1-ene-1-carboxylic acid	90-149	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
14751313-0	2004	Synthesis and COX-2 inhibitory properties of N-phenyl- and N-benzyl-substituted amides of 2-(4-methylsulfonylphenyl)cyclopent-1-ene-1-carboxylic acid and of their pyrazole, thiophene and isoxazole analogs.	pyrazole	163-171	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
14751313-0	2004	Synthesis and COX-2 inhibitory properties of N-phenyl- and N-benzyl-substituted amides of 2-(4-methylsulfonylphenyl)cyclopent-1-ene-1-carboxylic acid and of their pyrazole, thiophene and isoxazole analogs.	Thiophenes	173-182	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
14751313-0	2004	Synthesis and COX-2 inhibitory properties of N-phenyl- and N-benzyl-substituted amides of 2-(4-methylsulfonylphenyl)cyclopent-1-ene-1-carboxylic acid and of their pyrazole, thiophene and isoxazole analogs.	Isoxazoles	187-196	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
14751313-1	2004	Some N-phenyl- (7a-10a) and N-benzyl-substituted (7b-10b) amido analogs of cyclooxygenase (COX-2) selective tricyclic non-steroidal anti-inflammatory drugs have been synthesized with the aim to obtain information on the structural requirements for the COX-inhibitory activity.	n-phenyl- (7a-10a	5-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-96
14751313-1	2004	Some N-phenyl- (7a-10a) and N-benzyl-substituted (7b-10b) amido analogs of cyclooxygenase (COX-2) selective tricyclic non-steroidal anti-inflammatory drugs have been synthesized with the aim to obtain information on the structural requirements for the COX-inhibitory activity.	n-benzyl-substituted (7b-10b) amido	28-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-96
14751313-4	2004	These data have been tentatively explained by a conformational study which indicates that at least the N-phenyl-substituted amides 7a-9a present steric hindrances which may prevent a good interaction with COX-2 active site.	n-phenyl-substituted amides	103-130	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	205-210
14991469-0	2004	Oral etodolac, a COX-2 inhibitor, reduces postoperative pain immediately after fast-track cardiac surgery.	Etodolac	5-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22
15523159-4	2004	Nonsteroidal anitinflammatory drugs (NASIDs) such as celecoxib, are the most widely investigated COX-2 inhibitors.	Celecoxib	53-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
14711953-2	2004	COX-2-specific inhibitors such as celecoxib have recently been approved for human use.	Celecoxib	34-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
14693827-1	2004	Eicosanoids constitute a large family of biologically active lipid mediators that are produced by two enzyme classes, cyclooxygenases (COX-1 and COX-2) and lipoxygenases (5-LO, 12-LO, and 15-LO).	Eicosanoids	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-150
15301300-2	2004	INTRODUCTION: Cyclooxygenases 1 (Cox-1) and 2 (Cox-2) play a key role in arachidonic acid metabolism and in the regulation of eicosanoid production.	Arachidonic Acid	73-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
15301300-2	2004	INTRODUCTION: Cyclooxygenases 1 (Cox-1) and 2 (Cox-2) play a key role in arachidonic acid metabolism and in the regulation of eicosanoid production.	Eicosanoids	126-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
14716644-5	2004	Celecoxib, a selective COX-2 inhibitor, shows the same efficacy as indomethacin in the prevention of heterotopic ossification after hip prosthesis with significantly fewer side effects.	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-28
15147164-11	2004	The anti-inflammatory effect of the polymer-complexed drug was demonstrated by more rapid suppression of COX-2 mRNA levels than that achieved by the pure drug.	Polymers	36-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-110
15509014-0	2004	Sorption of Co(II), Ni(II), and Zn(II) on biogenic manganese oxides produced by a Mn-oxidizing fungus, strain KR21-2.	manganese oxide	51-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-18
15509014-1	2004	The characteristics of Co(II), Ni(II), and Zn(II) sorption on freshly produced biogenic Mn oxides by a Mn-oxidizing fungus, strain KR21-2, were investigated.	mn oxides	88-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-29
15509014-3	2004	The order of sorption efficiency on the biogenic Mn oxides was Co(II) &gt; Zn(II) &gt; Ni(II), while that on the synthetic Mn oxide was Zn(II) &gt; Co(II) &gt; Ni(II).	mn oxides	49-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-69
15509014-3	2004	The order of sorption efficiency on the biogenic Mn oxides was Co(II) &gt; Zn(II) &gt; Ni(II), while that on the synthetic Mn oxide was Zn(II) &gt; Co(II) &gt; Ni(II).	mn oxide	49-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-69
15509014-5	2004	Two-step extraction, using 10mM CuSO4 solution for exchangeable sorbed ions and 10-20mM hydroxylamine hydrochloride for ions bound to reducible Mn oxide phase, showed higher irreversibility of Co(II) and Ni(II) sorption on the biogenic Mn oxides while Zn(II) sorption was mostly reversible (Cu(II)-exchangeable).	Copper Sulfate	32-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	193-199
15509014-5	2004	Two-step extraction, using 10mM CuSO4 solution for exchangeable sorbed ions and 10-20mM hydroxylamine hydrochloride for ions bound to reducible Mn oxide phase, showed higher irreversibility of Co(II) and Ni(II) sorption on the biogenic Mn oxides while Zn(II) sorption was mostly reversible (Cu(II)-exchangeable).	Hydroxylamine	88-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	193-199
15509014-5	2004	Two-step extraction, using 10mM CuSO4 solution for exchangeable sorbed ions and 10-20mM hydroxylamine hydrochloride for ions bound to reducible Mn oxide phase, showed higher irreversibility of Co(II) and Ni(II) sorption on the biogenic Mn oxides while Zn(II) sorption was mostly reversible (Cu(II)-exchangeable).	Nickel(2+)	204-210	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	193-199
15509014-5	2004	Two-step extraction, using 10mM CuSO4 solution for exchangeable sorbed ions and 10-20mM hydroxylamine hydrochloride for ions bound to reducible Mn oxide phase, showed higher irreversibility of Co(II) and Ni(II) sorption on the biogenic Mn oxides while Zn(II) sorption was mostly reversible (Cu(II)-exchangeable).	mn oxides	236-245	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	193-199
15509014-5	2004	Two-step extraction, using 10mM CuSO4 solution for exchangeable sorbed ions and 10-20mM hydroxylamine hydrochloride for ions bound to reducible Mn oxide phase, showed higher irreversibility of Co(II) and Ni(II) sorption on the biogenic Mn oxides while Zn(II) sorption was mostly reversible (Cu(II)-exchangeable).	Zinc	252-258	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	193-199
15509014-5	2004	Two-step extraction, using 10mM CuSO4 solution for exchangeable sorbed ions and 10-20mM hydroxylamine hydrochloride for ions bound to reducible Mn oxide phase, showed higher irreversibility of Co(II) and Ni(II) sorption on the biogenic Mn oxides while Zn(II) sorption was mostly reversible (Cu(II)-exchangeable).	cu(ii)	291-297	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	193-199
15509014-6	2004	Sorptions of Co(II), Ni(II), and Zn(II) on the synthetic Mn oxide were, however, found to be mostly reversible.	mn oxide	57-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-19
15509014-7	2004	Higher irreversibility of Co(II) and Ni(II) sorption on the biogenic Mn oxides may partly explain higher accumulation of these metal ions in Mn oxide phases in natural environments.	mn oxides	69-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-32
15509014-7	2004	Higher irreversibility of Co(II) and Ni(II) sorption on the biogenic Mn oxides may partly explain higher accumulation of these metal ions in Mn oxide phases in natural environments.	Metals	127-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-32
15301300-13	2004	The significance of these findings has to be discussed with regard to the regulatory function of Cox-2 in eicosanoid release and the role of the latter in the immunology and pathophysiology of nasal polyps.	Eicosanoids	106-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
14991469-1	2004	PURPOSE: The present study was designed to evaluate the efficacy of a cyclooxygenase (COX)-2 inhibitor, etodolac, on postoperative pain after fast-track cardiac surgery, and to examine the changes in plasma etodolac concentration after oral administration.	Etodolac	104-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-92
14705234-0	2004	Efficacy and safety of tramadol/acetaminophen tablets (Ultracet) as add-on therapy for osteoarthritis pain in subjects receiving a COX-2 nonsteroidal antiinflammatory drug: a multicenter, randomized, double-blind, placebo-controlled trial.	Tramadol	23-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-136
14705234-10	2004	CONCLUSION: Tramadol 37.5 mg/APAP 325 mg combination tablets were effective and safe as add-on therapy with COX-2 NSAID for treatment of OA pain.	Tramadol	12-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-113
14654921-6	2004	The COX-2 inhibitor etodolac was found to inhibit cell invasion of LM-H3.	Etodolac	20-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
15287880-8	2004	Maximum stimulatory effect on C2H4 biosynthesis was observed in response to Co(II) application, while Fe(III) inhibited the biotransformation of KMBA into C2H4.	ethylene	30-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-82
15231456-5	2004	DSS and sinigrin were evaluated for their inhibitory effects on cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) enzymes, on lipid peroxidation, and on the proliferation of human colon (HCT-116), breast (MCF-7), lung (NCIH460), and central nervous system (CNS, SF-268) cancer cell lines.	sinigrin	8-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	111-116
14670476-0	2004	H-point standard addition method for simultaneous spectrophotometric determination of Co(II) and Ni(II) by 1-(2-pyridylazo)2-naphthol in micellar media.	1-(2-pyridylazo)-2-naphthol	107-133	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-92
14670476-1	2004	A very simple and selective spectrophotometric method for simultaneous determination of Co(II) and Ni(II) by 1-(2-pyridylazo) 2-naphthol (PAN), in micellar media, using H-point standard addition method (HPSAM) is described.	1-(2-pyridylazo)-2-naphthol	109-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-94
14670476-2	2004	The ligand and its metal complexes (Co(II)-PAN and Ni(II)-PAN) were made water-soluble by the neutral surfactant Triton X-100, and therefore, no extraction with organic solvents was required.	Metals	19-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-42
14670476-2	2004	The ligand and its metal complexes (Co(II)-PAN and Ni(II)-PAN) were made water-soluble by the neutral surfactant Triton X-100, and therefore, no extraction with organic solvents was required.	Water	73-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-42
14670476-2	2004	The ligand and its metal complexes (Co(II)-PAN and Ni(II)-PAN) were made water-soluble by the neutral surfactant Triton X-100, and therefore, no extraction with organic solvents was required.	Octoxynol	113-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-42
14989826-1	2004	OBJECTIVE: To investigate the effect of hydrogen peroxide (H(2)O(2)) on interleukin-1beta (IL-1beta)-induced cyclooxygenase-2 (COX-2) expression in human pulmonary epithelial cells (HPEC).	Hydrogen Peroxide	40-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	127-132
14989826-9	2004	CONCLUSION: Hydrogen peroxide upregulates IL-1beta-induced COX-2 expression in HPEC at transcriptional level.	Hydrogen Peroxide	12-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-64
14694045-7	2003	Moreover, increased levels of PGE(2) and PGF(2alpha) were measurable in sera from patients with GBS, CIDP, or VN and in cell culture supernatants from in vitro stimulated macrophages, indicative of COX-2 activity.	Prostaglandins E	30-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	198-203
14507922-7	2003	The study suggests that expression of COXs may influence A beta peptide generation through mechanisms that involve PG-E2-mediated potentiation of gamma-secretase activity, further supporting a role for COX-2 and COX-1 in Alzheimer"s disease neuropathology.	Dinoprostone	115-120	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	202-207
14507922-4	2003	Treatment of APP-overexpressing cells with the non-selective COX inhibitor ibuprofen (1 microM, 48 h) or with the specific gamma-secretase inhibitor L-685,458 significantly attenuated hCOX-1- and hCOX-2-mediated induction of A beta peptide generation and CTF-gamma cleavage product formation.	Ibuprofen	75-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	196-202
14680814-4	2003	Such inhibitory effect of CM-WI-38 on MIP-1alpha production was abrogated by treatment with indomethacin, NS-398 (a specific COX-2 inhibitor), or anti-prostaglandin E(2) antibody.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	106-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-130
14507922-4	2003	Treatment of APP-overexpressing cells with the non-selective COX inhibitor ibuprofen (1 microM, 48 h) or with the specific gamma-secretase inhibitor L-685,458 significantly attenuated hCOX-1- and hCOX-2-mediated induction of A beta peptide generation and CTF-gamma cleavage product formation.	l-685	149-154	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	196-202
15124935-3	2004	On the other hand, COX-2, expressed by cells involved in inflammation (e.g. macrophages, monocytes, synoviocytes), has emerged as the isoform that is primarily responsible for the synthesis of prostanoids involved in acute and chronic inflammatory states.	Prostaglandins	193-204	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-24
15124935-5	2004	Selective COX-2 inhibitors currently used in the clinic are the sulphonamides celecoxib and valdecoxib (parecoxib is a prodrug of valdecoxib), as well as the methylsulphones rofecoxib and etoricoxib.	Sulfonamides	64-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
15124935-5	2004	Selective COX-2 inhibitors currently used in the clinic are the sulphonamides celecoxib and valdecoxib (parecoxib is a prodrug of valdecoxib), as well as the methylsulphones rofecoxib and etoricoxib.	Celecoxib	78-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
15124935-5	2004	Selective COX-2 inhibitors currently used in the clinic are the sulphonamides celecoxib and valdecoxib (parecoxib is a prodrug of valdecoxib), as well as the methylsulphones rofecoxib and etoricoxib.	valdecoxib	92-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
15124935-5	2004	Selective COX-2 inhibitors currently used in the clinic are the sulphonamides celecoxib and valdecoxib (parecoxib is a prodrug of valdecoxib), as well as the methylsulphones rofecoxib and etoricoxib.	parecoxib	104-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
14640580-0	2003	Methanolic extract of adlay seed suppresses COX-2 expression of human lung cancer cells via inhibition of gene transcription.	methanolic	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-49
15124935-5	2004	Selective COX-2 inhibitors currently used in the clinic are the sulphonamides celecoxib and valdecoxib (parecoxib is a prodrug of valdecoxib), as well as the methylsulphones rofecoxib and etoricoxib.	valdecoxib	130-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
15124935-5	2004	Selective COX-2 inhibitors currently used in the clinic are the sulphonamides celecoxib and valdecoxib (parecoxib is a prodrug of valdecoxib), as well as the methylsulphones rofecoxib and etoricoxib.	Etoricoxib	188-198	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
14693324-7	2003	Established risk factors (age &gt; or =75 years, history of gastrointestinal hemorrhage or peptic ulcer disease, or concomitant warfarin or oral glucocorticoid use) were all significant predictors of COX-2 inhibitor use, but a multivariable model including only these risk factors discriminated poorly between the two patient groups (C statistic = 0.55).	Warfarin	128-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	200-205
14640580-2	2003	In this study, the methanolic extract of adlay seed was tested for its regulation of COX-2 expression of human lung cancer cells.	methanolic	19-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-90
14640580-3	2003	Western blot analysis showed that the methanolic extract of adlay seed inhibited basal and TPA-induced COX-2 expression in a dose-dependent fashion, whereas COX-1 expression was not affected.	methanolic	38-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-108
14640580-3	2003	Western blot analysis showed that the methanolic extract of adlay seed inhibited basal and TPA-induced COX-2 expression in a dose-dependent fashion, whereas COX-1 expression was not affected.	Tetradecanoylphorbol Acetate	91-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-108
14640580-4	2003	By using a promoter activity assay, it was found that the methanolic extract inhibited basal and TPA-stimulated COX-2 expression at the transcription level.	methanolic	58-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-117
14640580-4	2003	By using a promoter activity assay, it was found that the methanolic extract inhibited basal and TPA-stimulated COX-2 expression at the transcription level.	Tetradecanoylphorbol Acetate	97-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-117
14640580-5	2003	The effect of the methanolic extract on COX-2 expression in vivo was then investigated.	methanolic	18-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
14640580-7	2003	Taken together, these results suggest that inhibition of COX-2 is one of the mechanisms by which the methanolic extract of adlay seed inhibits cancer growth and prevents lung tumorigenesis.	methanolic	101-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-62
14642598-0	2003	Discovery of 2-phenyl-3-sulfonylphenyl-indole derivatives as a new class of selective COX-2 inhibitors.	2-phenyl-3-sulfonylphenyl-indole	13-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-91
14739609-4	2003	We also compared the effects of non-selective and isoenzyme selective COX-2 inhibitors on camptothecin-induced apoptosis in these three cell lines.	Camptothecin	90-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-75
14739610-6	2003	In contrast, sulindac sulfide (SSD) (which inhibits Cox-1 and Cox-2) 0-200 microM or sulindac sulfone (SSN) 0-500 microM (without significant activity against Cox-1 or Cox-2) caused identical decreases in cell number and increases in apoptosis in HT29 and HCT116 cells.	sulindac sulfide	13-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
14739610-8	2003	To determine that the higher levels of apoptosis in HT29 cells with SC236 &gt;75 microM were related to decreased Cox-2 protein levels, we decreased Cox-2 protein expression in HT29 cells with curcumin (diferuloylmethane) and studied its effect on SC236-induced apoptosis.	Curcumin	193-201	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	149-154
14739610-8	2003	To determine that the higher levels of apoptosis in HT29 cells with SC236 &gt;75 microM were related to decreased Cox-2 protein levels, we decreased Cox-2 protein expression in HT29 cells with curcumin (diferuloylmethane) and studied its effect on SC236-induced apoptosis.	4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide	68-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-119
14642598-1	2003	2-Sulfonylphenyl-3-phenyl-indole derivatives have been reported to be highly potent and selective COX-2 inhibitors previously.	2-sulfonylphenyl-3-phenyl-indole	0-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-103
14642598-2	2003	In this paper, the regio-isomeric analogues-2-phenyl-3-sulfonylphenyl-indoles were identified as potent and selective COX-2 inhibitors.	2-phenyl-3-sulfonylphenyl-indole	44-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-123
15075458-4	2003	SC-560, but not rofecoxib, caused intestinal hypermotility, bacterial invasion and the expression of COX-2 as well as iNOS mRNAs, yet the iNOS and MPO activity was increased only when rofecoxib was administered together with SC-560.	SC 560	0-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-106
14633764-4	2003	However, what is less well appreciated is the role that the COX 2 inhibitors may play in the development of renal failure which, when it occurs in a patient on metformin, can lead to a potentially disastrous outcome.	Metformin	160-169	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-65
14676104-1	2003	PURPOSE: Preclinical data suggest that the cyclooxygenase (COX)-2/prostaglandin (PG) E2 signaling pathway plays an essential role in conferring the malignant phenotype in non-small cell lung cancer.	prostaglandin (pg) e2	66-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-65
14676104-2	2003	We hypothesized that treatment with oral celecoxib, a selective COX-2 inhibitor, would favorably alter biomarkers of lung cancer risk.	Celecoxib	41-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-69
12970159-3	2003	PGE2 concentrations were significantly elevated in the cells transfected with the COX-2 sense compared with wild-type cells or cells transfected with the antisense cDNA (P &lt; 0.01).	Dinoprostone	0-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
12970159-10	2003	Coincubation of plasminogen with the cathepsin D inhibitor pepstatin A inhibited the cleavage of plasminogen to angiostatin in the COX-2 antisense conditioned media.	pepstatin	59-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-136
14760940-5	2003	Blocking of COX-2 by NS398 abolished PGE2 production, but did not alter the cytokine patterns induced by Gram-positive and Gram-negative bacteria.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	21-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-17
14760940-5	2003	Blocking of COX-2 by NS398 abolished PGE2 production, but did not alter the cytokine patterns induced by Gram-positive and Gram-negative bacteria.	Dinoprostone	37-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-17
14671209-10	2003	We conclude that protein levels of mPGES, as well as COX-2, can be stimulated by cytokines, potentially contributing to the increased prostaglandin production at the time of infection-driven preterm labor.	Prostaglandins	134-147	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-58
14634122-5	2003	Addition of exogenous PGE(1) or PGE(2) inhibited MMP-1, reversed the effects of COX inhibitors, and inhibited ERK activation, suggesting that COX-2 activity tonically inhibits MMP-1 production via ERK inhibition by E PGs.	Prostaglandins E	22-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	142-147
14634122-5	2003	Addition of exogenous PGE(1) or PGE(2) inhibited MMP-1, reversed the effects of COX inhibitors, and inhibited ERK activation, suggesting that COX-2 activity tonically inhibits MMP-1 production via ERK inhibition by E PGs.	Prostaglandins E	32-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	142-147
14634122-5	2003	Addition of exogenous PGE(1) or PGE(2) inhibited MMP-1, reversed the effects of COX inhibitors, and inhibited ERK activation, suggesting that COX-2 activity tonically inhibits MMP-1 production via ERK inhibition by E PGs.	Phosphatidylglycerols	217-220	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	142-147
14634122-8	2003	Our data indicate that: 1) ERK activation mediates MMP-1 but not MMP-13 release from FLSCs, 2) COX-2-derived E PGs inhibit MMP-1 release from FLSCs via inhibition of ERK, and 3) COX inhibitors, by attenuating PGE inhibition of ERK, enhance the release of MMP-1 by FLSC.	Prostaglandins E	209-212	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-100
15198407-1	2003	Valdecoxib, a COX-2 inhibitor, has recently been introduced as a gel formulation.	valdecoxib	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
14974816-3	2003	Non-steroidal anti-inflammatory drugs inhibit PG synthesis via COX-1 and/or COX-2 isoenzymes and may inhibit periodontal destruction.	pg	46-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-81
14974816-6	2003	The objective of this study was to determine the effects of COX-2 inhibitors on amounts of PGE2 and IL-6 made by IL-1beta-stimulated gingival fibroblasts.	Dinoprostone	91-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-65
29539078-3	2003	Non-steroidal anti-inflammatory drugs inhibit PG synthesis via COX-1 and/or COX-2 isoenzymes and may inhibit periodontal destruction.	pg	46-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-81
15075458-6	2003	The intestinal hypermotility response to indomethacin was prevented by both 16,16-dimethyl PGE(2) and atropine but not ampicillin, yet all these agents inhibited not only the bacterial invasion but also the expression of COX-2 as well as the iNOS activity in the intestinal mucosa following indomethacin treatment, resulting in preventing the intestinal lesions.	Indomethacin	41-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	221-226
29539078-6	2003	The objective of this study was to determine the effects of COX-2 inhibitors on amounts of PGE2 and IL-6 made by IL-1beta-stimulated gingival fibroblasts.	Dinoprostone	91-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-65
15075458-7	2003	These results suggest that inhibition of COX-1, despite causing intestinal hypermotility, bacterial invasion and iNOS expression, up-regulates the expression of COX-2, and the PGE(2) derived from COX-2 counteracts deleterious events caused by COX-1 inhibition and maintains the mucosal integrity.	Prostaglandins E	176-179	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	196-201
14671726-4	2003	RESULTS: COX-2 is upregulated in inflamed joint tissues and is responsible for elevated PGE2 production.	Dinoprostone	88-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	9-14
14655004-1	2003	The discovery of two isoforms of cyclooxygenases (COX-1 and COX-2) has provided a new insight into the involvement of prostaglandins in the clinical effectiveness and gastrointestinal toxicity of NSAIDs.	Prostaglandins	118-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-65
14655004-2	2003	Currently, there are four selective COX-2 inhibitors available in Germany: celecoxib, rofecoxib, valdecoxib and parecoxib.	Celecoxib	75-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-41
14655004-2	2003	Currently, there are four selective COX-2 inhibitors available in Germany: celecoxib, rofecoxib, valdecoxib and parecoxib.	rofecoxib	86-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-41
14655004-2	2003	Currently, there are four selective COX-2 inhibitors available in Germany: celecoxib, rofecoxib, valdecoxib and parecoxib.	valdecoxib	97-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-41
14655004-2	2003	Currently, there are four selective COX-2 inhibitors available in Germany: celecoxib, rofecoxib, valdecoxib and parecoxib.	parecoxib	112-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-41
14655004-4	2003	Parecoxib, the first selective COX-2 inhibitor for parenteral administration, has been approved for the short-term treatment of post-operative pain.	parecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-36
14655004-5	2003	The clinical efficacy of the marketed COX-2 inhibitors has been proved in large phase III clinical trials in comparison to both placebo and classical NSAIDs (e.g. diclofenac, naproxen).	Diclofenac	163-173	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-43
14655004-5	2003	The clinical efficacy of the marketed COX-2 inhibitors has been proved in large phase III clinical trials in comparison to both placebo and classical NSAIDs (e.g. diclofenac, naproxen).	Naproxen	175-183	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-43
14647459-7	2003	This suggests that COX-2 is the major source of PGE(2) in this cell line.	Prostaglandins E	48-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-24
14623265-6	2003	The guanylyl-cyclase inhibitor ODQ partially reversed the suppression of COX-2 activity by NO-aspirin, demonstrating a role of cGMP increase.	1H-(1,2,3)oxadiazolo(4,4-a)quinoxalin-1-one	31-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-78
14623265-6	2003	The guanylyl-cyclase inhibitor ODQ partially reversed the suppression of COX-2 activity by NO-aspirin, demonstrating a role of cGMP increase.	Aspirin	94-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-78
14623265-6	2003	The guanylyl-cyclase inhibitor ODQ partially reversed the suppression of COX-2 activity by NO-aspirin, demonstrating a role of cGMP increase.	Cyclic GMP	127-131	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-78
14623265-8	2003	COX-2 expression was not affected by NO-donors or NO-aspirin while aspirin or the selective COX-2-inhibitor DUP697 increased it.	DuP 697	108-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-97
14623265-9	2003	In conclusion, Nitroaspirin inhibits monocyte COX-2 activity by a cGMP-dependent mechanism.	nitroaspirin	15-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
14623265-9	2003	In conclusion, Nitroaspirin inhibits monocyte COX-2 activity by a cGMP-dependent mechanism.	Cyclic GMP	66-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
14647459-6	2003	In OVCAR-3 cells, PGE(2) production was inhibited by NS-398 in concentrations of 1 microM and by a COX-2-specific silencing RNA (siRNA), while a COX-1-specific siRNA did not have an effect.	Dinoprostone	18-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-104
14651817-2	2003	We evaluated celecoxib tolerance, a highly specific COX-2 inhibitor, in NSAIDs-sensitive patients.	Celecoxib	13-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-57
14763357-11	2003	The benefit related to the IN SUMMARY: Cox-2 specific antagonists seems dramatically reduced by the concomitant aspirin intake.	Aspirin	112-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-44
14606832-1	2003	Co(II) solution species containing 1 equiv of phenanthroline (phen), 2-methyl-1,10-phenanthroline (MMP), or 2,9-dimethyl-1,10-phenanthroline (DMP) ligand formed inner-sphere surface complexes when grafted on silica.	Phenanthrolines	46-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
14606832-1	2003	Co(II) solution species containing 1 equiv of phenanthroline (phen), 2-methyl-1,10-phenanthroline (MMP), or 2,9-dimethyl-1,10-phenanthroline (DMP) ligand formed inner-sphere surface complexes when grafted on silica.	Phenanthrolines	46-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
14606832-1	2003	Co(II) solution species containing 1 equiv of phenanthroline (phen), 2-methyl-1,10-phenanthroline (MMP), or 2,9-dimethyl-1,10-phenanthroline (DMP) ligand formed inner-sphere surface complexes when grafted on silica.	2-methyl-1,10-phenanthroline	69-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
14606832-1	2003	Co(II) solution species containing 1 equiv of phenanthroline (phen), 2-methyl-1,10-phenanthroline (MMP), or 2,9-dimethyl-1,10-phenanthroline (DMP) ligand formed inner-sphere surface complexes when grafted on silica.	neocuproine	108-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
14606832-1	2003	Co(II) solution species containing 1 equiv of phenanthroline (phen), 2-methyl-1,10-phenanthroline (MMP), or 2,9-dimethyl-1,10-phenanthroline (DMP) ligand formed inner-sphere surface complexes when grafted on silica.	neocuproine	142-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
14606832-1	2003	Co(II) solution species containing 1 equiv of phenanthroline (phen), 2-methyl-1,10-phenanthroline (MMP), or 2,9-dimethyl-1,10-phenanthroline (DMP) ligand formed inner-sphere surface complexes when grafted on silica.	Silicon Dioxide	208-214	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
14606832-10	2003	All three phenanthroline derivatives promoted surface binding of the Co(II) ion adducts, so that maximal binding occurred at lower pH values than for binding of [Co(H(2)O)(6)](2+), which formed exclusively tetrahedral adducts.	Phenanthrolines	10-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-75
14606832-10	2003	All three phenanthroline derivatives promoted surface binding of the Co(II) ion adducts, so that maximal binding occurred at lower pH values than for binding of [Co(H(2)O)(6)](2+), which formed exclusively tetrahedral adducts.	co(h(2)o)	162-171	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-75
14606843-9	2003	The Mn(II) complex 8.0.75CH(3)()CN.0.75Et(2)()O exhibits a dinuclear structure with bridging hydroxamate ligands, whereas the Co(II), Ni(II), and Zn(II) derivatives all exhibit mononuclear six-coordinate structures with a chelating hydroxamate ligand.	Manganese(2+)	4-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-132
14611204-3	2003	We report, herein, the preparation of gellike metallo-supramolecular polymers prepared from a monomer unit, which consists of a 2,6-bis-(benzimidazolyl)-4-hydroxypyridine unit attached to either end of a polyether chain, mixed with a transition metal ion (e.g., Co(II) or Zn(II)) and a small percentage of a lanthanoid metal (e.g., La(III), Eu(III)).	Metals	46-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	262-268
14611231-1	2003	A novel end-on azide-bridged homospin 1D chain, Co(bt)(N3)2 (1) (bt = 2,2"-bithiazoline), is constructed by sharing edges of Co(II) distorted octahedrons to form a helix, which shows magnetic hysteresis with steps and slow relaxation below 5-6 K, typical of single-chain magnet behavior.	Azides	15-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-130
14611231-1	2003	A novel end-on azide-bridged homospin 1D chain, Co(bt)(N3)2 (1) (bt = 2,2"-bithiazoline), is constructed by sharing edges of Co(II) distorted octahedrons to form a helix, which shows magnetic hysteresis with steps and slow relaxation below 5-6 K, typical of single-chain magnet behavior.	co(bt)(n3)2 (1)	48-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-130
14611231-1	2003	A novel end-on azide-bridged homospin 1D chain, Co(bt)(N3)2 (1) (bt = 2,2"-bithiazoline), is constructed by sharing edges of Co(II) distorted octahedrons to form a helix, which shows magnetic hysteresis with steps and slow relaxation below 5-6 K, typical of single-chain magnet behavior.	benzothiazole	51-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-130
14616020-0	2003	Polarographic behavior of Co(II)-BSA or -HSA complex in the presence of a guanidine modifier.	Altretamine	41-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-32
14616020-0	2003	Polarographic behavior of Co(II)-BSA or -HSA complex in the presence of a guanidine modifier.	Guanidine	74-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-32
14616020-2	2003	The interaction of BSA with guanidine in an alkaline solution results in its Co(II) complex with a positive excess charge.	Guanidine	28-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-83
14616020-4	2003	The adsorption efficiently accumulates the electrochemical active complex of Co(II)-BSA onto the DME.	dimethylethylsilylimidazole	97-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-83
14616020-6	2003	In the absence of guanidine, the complex of Co(II)-BSA with a negative excess charge is repulsed by the DME.	Guanidine	18-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-50
14616020-6	2003	In the absence of guanidine, the complex of Co(II)-BSA with a negative excess charge is repulsed by the DME.	dimethylethylsilylimidazole	104-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-50
14633677-5	2003	Interestingly, NO-ASA induced COX-2 expression, although it had no effect on COX-1.	Aspirin	18-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-35
14633677-6	2003	COX-2 induction was accompanied by increased prostaglandin E(2) production.	Dinoprostone	45-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
18969204-3	2003	The developed method showed superior extraction qualities with high metal loading capacities of 71, 85, 182, 130 and 46 mg g(-1) for Ni(II), Cd(II), Pb(II), Cu(II) and Co(II), respectively.	Metals	68-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	168-174
18969204-4	2003	The rate of metal ion uptake i.e. kinetics studies performed under optimum levels showed a time duration of &lt;5 min except for Co(II) which required 20 min, for complete metal ion saturation.	Metals	172-177	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-135
14640056-2	2003	The mechanisms by which acetylsalicylic acid and other NSAIDs, including COX-2 inhibitors, exert this effect include: inhibition of COX-2, induction of apoptosis and induction of the P21 protein that controls the development of crypt cells.	Aspirin	24-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-78
14640056-2	2003	The mechanisms by which acetylsalicylic acid and other NSAIDs, including COX-2 inhibitors, exert this effect include: inhibition of COX-2, induction of apoptosis and induction of the P21 protein that controls the development of crypt cells.	Aspirin	24-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-137
14596920-0	2003	Sodium butyrate inhibits angiogenesis of human intestinal microvascular endothelial cells through COX-2 inhibition.	Butyric Acid	0-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-103
14596920-3	2003	Butyrate also inhibited COX-2 expression as well as prostaglandin (PG)E2 and PGI2 production, and administration of PGI2 analog partially reversed the effect of butyrate on HIMEC angiogenesis.	Butyrates	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
14596920-4	2003	These results indicate that sodium butyrate inhibits HIMEC angiogenesis through down-regulation of COX-2 expression and PG production, and suggest that anti-angiogenic mechanisms may also be involved in the inhibitory effect of sodium butyrate on tumor growth.	Butyric Acid	28-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-104
14552773-0	2003	Exploring selectivity requirements for COX-2 versus COX-1 binding of 3,4-diaryloxazolones using E-state index.	3,4-diaryloxazolones	69-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-44
14552773-1	2003	Considering the importance of developing selective COX-2 inhibitors, the present paper explores selectivity requirements for COX-2 versus COX-1 binding of 3,4-diaryloxazolones using electrotopological state (E-state) index.	3,4-diaryloxazolones	155-175	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-56
14552773-1	2003	Considering the importance of developing selective COX-2 inhibitors, the present paper explores selectivity requirements for COX-2 versus COX-1 binding of 3,4-diaryloxazolones using electrotopological state (E-state) index.	3,4-diaryloxazolones	155-175	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-130
14552773-2	2003	The study also shows the utility of E-state index in developing statistically acceptable model having direct physicochemical significance: electron density distribution of different atoms of the oxazolone ring and attached two phenyl rings are important for the selective binding with COX-2 over COX-1.	Oxazolone	195-204	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	285-290
14552773-4	2003	Further, an amino substituent at R(2) position (i.e., sulfonamide compound) is favorable for increasing COX-2 selectivity when the R(3) position is unsubstituted.	Sulfonamides	54-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
14577772-5	2003	Its eight cyanide groups are coordinated to Co(II) ions which have two coordinated water molecules in trans position.	Cyanides	10-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-50
14577772-5	2003	Its eight cyanide groups are coordinated to Co(II) ions which have two coordinated water molecules in trans position.	Water	83-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-50
14577772-8	2003	Only six of its eight cyanide groups are coordinated to Co(II) ions while the other two are terminal.	Cyanides	22-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-62
14724542-1	2003	INTRODUCTION: Celecoxib (Celebrex) is a Cox 2 selective non steroidal anti-inflammatory agent.	Celecoxib	14-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
14724542-1	2003	INTRODUCTION: Celecoxib (Celebrex) is a Cox 2 selective non steroidal anti-inflammatory agent.	Celecoxib	25-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
14530214-3	2003	In this study, the effects and action mechanisms of vanilloid analogs on iNOS and COX-2 expression were investigated in RAW264.7 macrophages.	Capsaicin	52-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
14530214-7	2003	Capsaicin also transcriptionally inhibited LPS- and PMA-induced COX-2 expression and PGE2 production.	Capsaicin	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-69
14530214-11	2003	Nevertheless, it mimicked vanilloids in inhibiting iNOS/NO and COX-2/PGE2 induction with an IC50 value of 3 microm.	vanilloids	26-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-68
14530214-19	2003	In conclusion, vanilloids can modulate the expression of inflammatory iNOS and COX-2 genes in macrophages through interference with upstream signalling events of LPS and IFN-gamma.	vanilloids	15-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-84
14602487-6	2003	METHODS: We studied the expression of Cox-2 by immunohistochemistry in 106 primary breast carcinoma specimens collected over a three-year period, using a commercially available polyclonal antibody on formalin-fixed, paraffin-embedded tissue.	Formaldehyde	200-208	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-43
14602487-6	2003	METHODS: We studied the expression of Cox-2 by immunohistochemistry in 106 primary breast carcinoma specimens collected over a three-year period, using a commercially available polyclonal antibody on formalin-fixed, paraffin-embedded tissue.	Paraffin	216-224	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-43
14572603-9	2003	From the results based on an in vitro leukocyte differentiation model, we speculated that the antioxidant effect of the COX-2 inhibitors might be partly associated with both counteraction of proinflammatory cytokine-enhanced ROS generation and inhibition of CD11b, an important molecule for cell adhesion, expression.	ros	225-228	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-125
14532971-7	2003	Transient transfection of Kato III with cox-2 was associated with increased COX-2 expression, higher PGE2 production and upregulated VEGF expressions.	Dinoprostone	101-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
14532971-8	2003	Treatment with NS398, a specific COX-2 inhibitor, reduced VEGF expression in COX-2 expressing Kato III cells by 25%.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	15-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-38
14532971-8	2003	Treatment with NS398, a specific COX-2 inhibitor, reduced VEGF expression in COX-2 expressing Kato III cells by 25%.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	15-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-82
14532998-1	2003	The aims of this study were to examine the overexpression of COX-2 protein and its relationship to apoptosis in cervical carcinoma patients treated with neoadjuvant chemo-therapy (NAC), and to assess the potential role of COX-2 as a predictor of the response to NAC in a series of patients with cervical carcinoma.	nac	180-183	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-66
14532998-1	2003	The aims of this study were to examine the overexpression of COX-2 protein and its relationship to apoptosis in cervical carcinoma patients treated with neoadjuvant chemo-therapy (NAC), and to assess the potential role of COX-2 as a predictor of the response to NAC in a series of patients with cervical carcinoma.	nac	262-265	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-66
14532998-12	2003	In COX-2 protein-negative patients with squamous cell carcinoma, the AI ratio was 0.96+/-0.46 following one arterial infusion of cisplatin and 3.19+/-2.72 following two infusions of cisplatin.	Cisplatin	129-138	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	3-8
14532998-12	2003	In COX-2 protein-negative patients with squamous cell carcinoma, the AI ratio was 0.96+/-0.46 following one arterial infusion of cisplatin and 3.19+/-2.72 following two infusions of cisplatin.	Cisplatin	182-191	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	3-8
14532998-14	2003	Our findings suggest that COX-2 protein expression could be used as a predictor of chemoresistance and that assessment of the COX-2 status could be useful to identify cervical cancer patients who may benefit from NAC.	nac	213-216	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-131
14658947-2	2003	We sought to determine whether NSAIDs that selectively inhibit cyclooxygenase (COX) 2 also elevate serum lithium concentrations.	Lithium	105-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-85
14658947-6	2003	RESULTS: Eighteen cases of increased serum lithium concentrations after the addition of one of the COX-2 inhibitors to stable lithium therapy were retrieved from AERS, 13 with rofecoxib and 5 with celecoxib.	Lithium	43-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-104
14658947-10	2003	CONCLUSION: Clinicians should consider NSAID use in the differential diagnosis of lithium toxicity, monitor patients" serum lithium concentrations during the initiation or discontinuation of NSAID therapy, and be aware that the selective COX-2 inhibitors can increase serum lithium concentrations leading to toxicity.	Lithium	82-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	238-243
14658947-10	2003	CONCLUSION: Clinicians should consider NSAID use in the differential diagnosis of lithium toxicity, monitor patients" serum lithium concentrations during the initiation or discontinuation of NSAID therapy, and be aware that the selective COX-2 inhibitors can increase serum lithium concentrations leading to toxicity.	Lithium	124-131	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	238-243
14658947-10	2003	CONCLUSION: Clinicians should consider NSAID use in the differential diagnosis of lithium toxicity, monitor patients" serum lithium concentrations during the initiation or discontinuation of NSAID therapy, and be aware that the selective COX-2 inhibitors can increase serum lithium concentrations leading to toxicity.	Lithium	124-131	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	238-243
14708615-7	2003	We further demonstrated by FACS analyses that NAPS- or TAPS-mediated apoptosis was greatly increased in cells treated with celecoxib, a selective COX-2 inhibitor.	N-acetylphytosphingosine	46-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	146-151
14708615-7	2003	We further demonstrated by FACS analyses that NAPS- or TAPS-mediated apoptosis was greatly increased in cells treated with celecoxib, a selective COX-2 inhibitor.	tetraacetyl-phytosphingosine	55-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	146-151
14708615-7	2003	We further demonstrated by FACS analyses that NAPS- or TAPS-mediated apoptosis was greatly increased in cells treated with celecoxib, a selective COX-2 inhibitor.	Celecoxib	123-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	146-151
14708615-8	2003	Inhibition of the ERK pathway apparently involved in the NAPS/TAPS-mediated COX-2 expression enhanced the NAPS/TAPS-mediated apoptosis, whereas inhibition of the P38 pathway did not.	tetraacetyl-phytosphingosine	62-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-81
14708615-8	2003	Inhibition of the ERK pathway apparently involved in the NAPS/TAPS-mediated COX-2 expression enhanced the NAPS/TAPS-mediated apoptosis, whereas inhibition of the P38 pathway did not.	tetraacetyl-phytosphingosine	111-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-81
14708615-9	2003	These results suggest that expression of COX-2 in the TAPS- or NAPS-treated cells may be increased to counteract the effect of those compounds on apoptosis.	N-acetylphytosphingosine	63-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-46
14677191-1	2003	OBJECTIVE: To assess the effects of celecoxib, a cyclooxygenase (COX-2) selective inhibitor, on the metabolism of hyaluronan (HA) and proteoglycans (PG) in human cartilage explants with midrange severity of osteoarthritis (OA).	Celecoxib	36-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-70
14677191-1	2003	OBJECTIVE: To assess the effects of celecoxib, a cyclooxygenase (COX-2) selective inhibitor, on the metabolism of hyaluronan (HA) and proteoglycans (PG) in human cartilage explants with midrange severity of osteoarthritis (OA).	Hyaluronic Acid	114-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-70
14668809-0	2003	COX-2 and beyond: Approaches to prostaglandin inhibition in human disease.	Prostaglandins	32-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
14534681-10	2003	Since a high frequency of COX-2 is positive in PBM, COX-2 inhibitors such as NSAIDs may play an important role in preventing carcinogenesis.	pbm	47-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-31
14534681-10	2003	Since a high frequency of COX-2 is positive in PBM, COX-2 inhibitors such as NSAIDs may play an important role in preventing carcinogenesis.	pbm	47-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-57
14730095-4	2003	Indomethacin (IND), an inhibitor preferentially acting on COX-1, as well as nimesulide (NIM) and celecoxib (CECOX), i.e. preferential and selective inhibitor of COX-2, respectively, administered icv almost completely blocked the antinociceptive effect of ACETA in Randall-Selitto method.	Indomethacin	0-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	161-166
14730095-4	2003	Indomethacin (IND), an inhibitor preferentially acting on COX-1, as well as nimesulide (NIM) and celecoxib (CECOX), i.e. preferential and selective inhibitor of COX-2, respectively, administered icv almost completely blocked the antinociceptive effect of ACETA in Randall-Selitto method.	Indomethacin	14-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	161-166
14730095-4	2003	Indomethacin (IND), an inhibitor preferentially acting on COX-1, as well as nimesulide (NIM) and celecoxib (CECOX), i.e. preferential and selective inhibitor of COX-2, respectively, administered icv almost completely blocked the antinociceptive effect of ACETA in Randall-Selitto method.	nimesulide	76-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	161-166
14730095-4	2003	Indomethacin (IND), an inhibitor preferentially acting on COX-1, as well as nimesulide (NIM) and celecoxib (CECOX), i.e. preferential and selective inhibitor of COX-2, respectively, administered icv almost completely blocked the antinociceptive effect of ACETA in Randall-Selitto method.	Celecoxib	97-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	161-166
14730095-4	2003	Indomethacin (IND), an inhibitor preferentially acting on COX-1, as well as nimesulide (NIM) and celecoxib (CECOX), i.e. preferential and selective inhibitor of COX-2, respectively, administered icv almost completely blocked the antinociceptive effect of ACETA in Randall-Selitto method.	Celecoxib	108-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	161-166
14730095-4	2003	Indomethacin (IND), an inhibitor preferentially acting on COX-1, as well as nimesulide (NIM) and celecoxib (CECOX), i.e. preferential and selective inhibitor of COX-2, respectively, administered icv almost completely blocked the antinociceptive effect of ACETA in Randall-Selitto method.	icv	195-198	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	161-166
14730095-4	2003	Indomethacin (IND), an inhibitor preferentially acting on COX-1, as well as nimesulide (NIM) and celecoxib (CECOX), i.e. preferential and selective inhibitor of COX-2, respectively, administered icv almost completely blocked the antinociceptive effect of ACETA in Randall-Selitto method.	Acetaminophen	255-260	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	161-166
14714475-5	2003	In the presence of RNase, the electrocatalytic effect was maximum at a concentration of Co(II) in the ammoniac buffer, equal to 2 x 10(-4) M (pH 10.0).	Ammonia	102-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-94
14585914-5	2003	Results demonstrate that the median duration of treatment was longer among patients initially prescribed COX-2-specific inhibitors (30 days and 23 days for celecoxib and rofecoxib respectively) than in those prescribed non-selective NSAIDs (10 days).	Celecoxib	156-165	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-110
14585914-5	2003	Results demonstrate that the median duration of treatment was longer among patients initially prescribed COX-2-specific inhibitors (30 days and 23 days for celecoxib and rofecoxib respectively) than in those prescribed non-selective NSAIDs (10 days).	rofecoxib	170-179	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-110
14585915-13	2003	In contrast to non-specific NSAIDs, patients who received a prescription for a COX-2-specific inhibitor had significantly lower adjusted odds (OR = 0.22) of having H2RA/PPI or misoprostol coprescribed.	Misoprostol	176-187	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-84
14585916-5	2003	In comparative trials of celecoxib or valdecoxib with non-specific NSAIDs, COX-2-specific inhibitors were demonstrated to have superior dyspepsia tolerability than non-specific NSAIDs.	Celecoxib	25-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
14585916-5	2003	In comparative trials of celecoxib or valdecoxib with non-specific NSAIDs, COX-2-specific inhibitors were demonstrated to have superior dyspepsia tolerability than non-specific NSAIDs.	valdecoxib	38-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
14576372-3	2003	However, the cardiovascular safety of selective COX-2 inhibitors has been questioned because they selectively reduce prostacyclin production, thus disrupting the normal homeostatic balance and promoting a prothrombotic state.	Epoprostenol	117-129	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-53
14561922-3	2003	Mortality after injection of 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine (MPTP, a chemical known to cause parkinsonism in humans) in heterozygous COX-2-deficient mice was lower than that in wild-type mice.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	29-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-152
14561922-3	2003	Mortality after injection of 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine (MPTP, a chemical known to cause parkinsonism in humans) in heterozygous COX-2-deficient mice was lower than that in wild-type mice.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	75-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-152
12907684-3	2003	Disruption of the actin cytoskeleton by cytochalasin D (CD) inhibited NO-induced apoptosis, dedifferentiation, COX-2 expression, and prostaglandin E2 production in chondrocytes cultured on plastic or during cartilage explants culture.	Cytochalasin D	40-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	111-116
12907684-3	2003	Disruption of the actin cytoskeleton by cytochalasin D (CD) inhibited NO-induced apoptosis, dedifferentiation, COX-2 expression, and prostaglandin E2 production in chondrocytes cultured on plastic or during cartilage explants culture.	Cytochalasin D	56-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	111-116
12907684-4	2003	CD treatment did not affect ERK-1/-2 activation but blocked the signaling events necessary for NO-induced dedifferentiation, apoptosis, and COX-2 expression such as activation of p38 kinase and inhibition of PKCalpha and -zeta.	Cytochalasin D	0-2	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-145
14531705-1	2003	Variations in the EPR spectra of Co(II)(octaethylporphyrin) doped in crystalline diamagnetic hosts and a reassessment of the electronic structure of four-coordinate cobalt(II).	octaethylporphyrin	40-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-39
14531705-5	2003	For Co(II)(OEP) doped into tetragonal Ni(II)(OEP) (which displays a very large g( perpendicular ) of 3.405 and a very small g( parallel ) of 1.544) and several other crystals containing four-coordinate metal sites, the g components could not be fit using existing theory with the assumption of the usual z(2) ground state.	Nickel(2+)	38-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-15
14531705-5	2003	For Co(II)(OEP) doped into tetragonal Ni(II)(OEP) (which displays a very large g( perpendicular ) of 3.405 and a very small g( parallel ) of 1.544) and several other crystals containing four-coordinate metal sites, the g components could not be fit using existing theory with the assumption of the usual z(2) ground state.	Nickel(2+)	38-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-14
14583492-2	2003	The purpose of this study was to determine whether an angiogenic antagonist, SU5416, could inhibit endogenous and phorbol 12-myristate 13-acetate (PMA)-mediated induction of COX-2 expression.	Semaxinib	77-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	174-179
14583492-2	2003	The purpose of this study was to determine whether an angiogenic antagonist, SU5416, could inhibit endogenous and phorbol 12-myristate 13-acetate (PMA)-mediated induction of COX-2 expression.	Tetradecanoylphorbol Acetate	114-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	174-179
14680814-4	2003	Such inhibitory effect of CM-WI-38 on MIP-1alpha production was abrogated by treatment with indomethacin, NS-398 (a specific COX-2 inhibitor), or anti-prostaglandin E(2) antibody.	cm-wi-38	26-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-130
14514306-0	2003	Photochemical behavior of azobenzene-conjugated CoII, CoIII, and FeII bis(terpyridine) complexes.	azobenzene	26-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-52
14583492-2	2003	The purpose of this study was to determine whether an angiogenic antagonist, SU5416, could inhibit endogenous and phorbol 12-myristate 13-acetate (PMA)-mediated induction of COX-2 expression.	Tetradecanoylphorbol Acetate	147-150	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	174-179
14583492-3	2003	SU5416 (5 micro M) inhibited endogenous as well as PMA-mediated induction of COX-2 expression when analyzed by immunoblot and Northern blot analysis.	Semaxinib	0-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-82
14583492-5	2003	PMA is a potent inducer of reactive oxygen species that can play an important role during the induction of COX-2 expression.	Reactive Oxygen Species	27-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-112
14583492-7	2003	An inhibitor of NADPH oxidase (diphenyleneiodonium chloride) blocked the PMA-mediated induction of COX-2 expression.	diphenyleneiodonium	31-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-104
14583492-7	2003	An inhibitor of NADPH oxidase (diphenyleneiodonium chloride) blocked the PMA-mediated induction of COX-2 expression.	Tetradecanoylphorbol Acetate	73-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-104
14583492-10	2003	When we blocked the PMA-mediated production of reactive oxygen species by blocking NADPH oxidase with SU5416, COX-2 expression and PGE(2) synthesis were also inhibited.	Reactive Oxygen Species	47-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-115
14583492-11	2003	Our results suggest that inhibition of NADPH oxidase activity, blocking of COX-2 expression, and PGE(2) synthesis may represent novel targets for SU5416.	Semaxinib	146-152	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
14514306-1	2003	Azobenzene-conjugated mononuclear and dinuclear terpyridyl complexes of Co(II), Co(III), and Fe(II) were synthesized, and their photoisomerization behavior was investigated.	azobenzene	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-78
12874281-5	2003	In fresh human monocytes exposed to hypoxia (1% O2), there was an increase in COX-2 protein compared with cells in normoxia, and this was attributable to increased transcription and mRNA stability.	Oxygen	48-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-83
14514306-3	2003	For the Co(II) complexes, BPh(4) salts undergo cis-to-trans isomerization in propylene carbonate by both photoirradiation with visible light (435 nm) and heat, indicating that reversible trans-cis isomerization has occurred.	bph(4) salts	26-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	8-14
14514306-3	2003	For the Co(II) complexes, BPh(4) salts undergo cis-to-trans isomerization in propylene carbonate by both photoirradiation with visible light (435 nm) and heat, indicating that reversible trans-cis isomerization has occurred.	propylene carbonate	77-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	8-14
14514319-3	2003	The temperature-dependent electronic and spectral properties of solutions containing the [Co(III)(tpy)(Cat-N-SQ)](+) suggest that this compound undergoes a thermally driven valence tautomeric interconversion to [Co(II)(tpy)(Cat-N-BQ)](+) complex, the metal ion being in high-spin configuration.	Nitrogen	107-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-95
14514319-3	2003	The temperature-dependent electronic and spectral properties of solutions containing the [Co(III)(tpy)(Cat-N-SQ)](+) suggest that this compound undergoes a thermally driven valence tautomeric interconversion to [Co(II)(tpy)(Cat-N-BQ)](+) complex, the metal ion being in high-spin configuration.	cat-n-bq)	224-233	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-95
14514319-3	2003	The temperature-dependent electronic and spectral properties of solutions containing the [Co(III)(tpy)(Cat-N-SQ)](+) suggest that this compound undergoes a thermally driven valence tautomeric interconversion to [Co(II)(tpy)(Cat-N-BQ)](+) complex, the metal ion being in high-spin configuration.	Metals	251-256	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-95
14587717-1	2003	Reaction of the bis-bidentate ligand L1, having two bidentate pyrazolyl-pyridine termini, with Co(II) or Zn(II) results in formation of the complexes [M8(L1)12]X16 (X = perchlorate or tetrafluoroborate); [Zn8(L1)2](ClO4)16 has been structurally characterised and is a cube with a metal ion at each corner, a bridging ligand along each edge, and an anion in the central cavity.	pyrazolyl-pyridine	62-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-101
14587717-1	2003	Reaction of the bis-bidentate ligand L1, having two bidentate pyrazolyl-pyridine termini, with Co(II) or Zn(II) results in formation of the complexes [M8(L1)12]X16 (X = perchlorate or tetrafluoroborate); [Zn8(L1)2](ClO4)16 has been structurally characterised and is a cube with a metal ion at each corner, a bridging ligand along each edge, and an anion in the central cavity.	[m8(l1)12]x16	150-163	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-101
14587717-1	2003	Reaction of the bis-bidentate ligand L1, having two bidentate pyrazolyl-pyridine termini, with Co(II) or Zn(II) results in formation of the complexes [M8(L1)12]X16 (X = perchlorate or tetrafluoroborate); [Zn8(L1)2](ClO4)16 has been structurally characterised and is a cube with a metal ion at each corner, a bridging ligand along each edge, and an anion in the central cavity.	perchlorate	169-180	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-101
14587717-1	2003	Reaction of the bis-bidentate ligand L1, having two bidentate pyrazolyl-pyridine termini, with Co(II) or Zn(II) results in formation of the complexes [M8(L1)12]X16 (X = perchlorate or tetrafluoroborate); [Zn8(L1)2](ClO4)16 has been structurally characterised and is a cube with a metal ion at each corner, a bridging ligand along each edge, and an anion in the central cavity.	fluoroboric acid	184-201	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-101
14587717-1	2003	Reaction of the bis-bidentate ligand L1, having two bidentate pyrazolyl-pyridine termini, with Co(II) or Zn(II) results in formation of the complexes [M8(L1)12]X16 (X = perchlorate or tetrafluoroborate); [Zn8(L1)2](ClO4)16 has been structurally characterised and is a cube with a metal ion at each corner, a bridging ligand along each edge, and an anion in the central cavity.	[zn8(l1)2](clo4)16	204-222	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-101
14587717-1	2003	Reaction of the bis-bidentate ligand L1, having two bidentate pyrazolyl-pyridine termini, with Co(II) or Zn(II) results in formation of the complexes [M8(L1)12]X16 (X = perchlorate or tetrafluoroborate); [Zn8(L1)2](ClO4)16 has been structurally characterised and is a cube with a metal ion at each corner, a bridging ligand along each edge, and an anion in the central cavity.	Metals	280-285	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-101
14520472-0	2003	Increased NF-kappaB DNA binding but not transcriptional activity during apoptosis induced by the COX-2-selective inhibitor NS-398 in colorectal carcinoma cells.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	123-129	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
14520472-4	2003	The effects of highly COX-2-selective NSAIDs such as NS-398 on NF-kappaB in colorectal tumour cells have not been reported.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	53-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-27
14520472-9	2003	This indicates that NF-kappaB activated by NS-398 is transcriptionally inactive and is an encouraging result for the use of COX-2-selective NSAIDs not only in chemoprevention but also as novel therapies for colon cancer.	Nitrogen	43-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	124-129
14530224-2	2003	Unlike NSAIDs, rofecoxib targets only the COX-2 isoform.	rofecoxib	15-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47
12972011-6	2003	It is the type 2 isoform of cyclo-oxygenase (COX-2), which is important for the production of prostaglandins within intrauterine tissues and that up-regulation of COX-2 is associated with labour.	Prostaglandins	94-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-50
14504873-0	2003	A comparative study of the effect of rofecoxib (a COX 2 inhibitor) and naproxen sodium on analgesic requirements after abdominal hysterectomy.	rofecoxib	37-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-55
12832284-5	2003	The production of PGE2 was also inhibited by indomethacin; a selective cyclooxygenase (COX)-2 inhibitor, celecoxib; and dexamethasone.	Dinoprostone	18-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-93
12832284-5	2003	The production of PGE2 was also inhibited by indomethacin; a selective cyclooxygenase (COX)-2 inhibitor, celecoxib; and dexamethasone.	Indomethacin	45-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-93
12832284-5	2003	The production of PGE2 was also inhibited by indomethacin; a selective cyclooxygenase (COX)-2 inhibitor, celecoxib; and dexamethasone.	Celecoxib	105-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-93
12832284-7	2003	Dexamethasone inhibited COX-2 gene transcription.	Dexamethasone	0-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
12972011-6	2003	It is the type 2 isoform of cyclo-oxygenase (COX-2), which is important for the production of prostaglandins within intrauterine tissues and that up-regulation of COX-2 is associated with labour.	Prostaglandins	94-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	163-168
14514642-3	2003	We first confirmed that incubation of HMC with 30 mmol/l glucose significantly increased COX-2 mRNA but not COX-1 mRNA, compared with 5.6 mmol/l glucose.	(2E,2'E)-1,1'-(3-hydroxy-5-methylbiphenyl-2,6-diyl)bis(3-(3-chlorophenyl)prop-2-en-1-one)	38-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-94
14555539-4	2003	Nuclear protein binding activities to three response elements located in the COX-2 promoter [nuclear factor kappaB (NFkappaB), cyclic AMP response element, and activator protein (AP)-2] were measured by gel mobility shift assays.	Cyclic AMP	127-137	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-82
14555539-9	2003	This down-regulation of PPARgamma mRNA by EGF was blocked in the presence of NS-398, a selective COX-2 inhibitor.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	77-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
14530796-5	2003	This is based on the initial hypothesis that considered COX-2 as the enzyme responsible for the generation of prostaglandins only in inflammation, and, therefore, uniquely responsible for inflammation, pain and fever.	Prostaglandins	110-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-61
14530796-10	2003	Molecules like nitro-NSAIDs or tromethamine salt derivatives have been synthesized considering that both COX-1 and COX-2 are responsible for the synthesis of prostaglandins involved either in homeostatic functions or inflammation.	nitro	15-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-120
14530796-10	2003	Molecules like nitro-NSAIDs or tromethamine salt derivatives have been synthesized considering that both COX-1 and COX-2 are responsible for the synthesis of prostaglandins involved either in homeostatic functions or inflammation.	tromethamine salt	31-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-120
14530796-10	2003	Molecules like nitro-NSAIDs or tromethamine salt derivatives have been synthesized considering that both COX-1 and COX-2 are responsible for the synthesis of prostaglandins involved either in homeostatic functions or inflammation.	Prostaglandins	158-172	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-120
14514642-3	2003	We first confirmed that incubation of HMC with 30 mmol/l glucose significantly increased COX-2 mRNA but not COX-1 mRNA, compared with 5.6 mmol/l glucose.	Glucose	57-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-94
14627347-1	2003	The long-term (mean of 16.4 +/- 4.2 months) efficacy and safety of rofecoxib (a specific COX-2 inhibitor) in maintaining the colon free of polyps in familial polyposis patients was assessed.	rofecoxib	67-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-94
14514642-4	2003	Similarly, incubation of HMCs with 30 mmol/l glucose significantly increased mitochondrial membrane potential, intracellular ROS production, COX-2 protein expression, and PGE2 synthesis, and these events were completely suppressed by thenoyltrifluoroacetone or carbonyl cyanide m-chlorophenylhydrazone, inhibitors of mitochondrial metabolism, or by overexpression of uncoupling protein-1 or manganese superoxide dismutase.	Glucose	45-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	141-146
14514642-4	2003	Similarly, incubation of HMCs with 30 mmol/l glucose significantly increased mitochondrial membrane potential, intracellular ROS production, COX-2 protein expression, and PGE2 synthesis, and these events were completely suppressed by thenoyltrifluoroacetone or carbonyl cyanide m-chlorophenylhydrazone, inhibitors of mitochondrial metabolism, or by overexpression of uncoupling protein-1 or manganese superoxide dismutase.	Thenoyltrifluoroacetone	234-257	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	141-146
14514642-4	2003	Similarly, incubation of HMCs with 30 mmol/l glucose significantly increased mitochondrial membrane potential, intracellular ROS production, COX-2 protein expression, and PGE2 synthesis, and these events were completely suppressed by thenoyltrifluoroacetone or carbonyl cyanide m-chlorophenylhydrazone, inhibitors of mitochondrial metabolism, or by overexpression of uncoupling protein-1 or manganese superoxide dismutase.	Carbonyl Cyanide m-Chlorophenyl Hydrazone	261-301	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	141-146
14514642-7	2003	Our results suggest that hyperglycemia increases mitochondrial ROS production, resulting in NF-kappaB activation, COX-2 mRNA induction, COX-2 protein production, and PGE2 synthesis.	Reactive Oxygen Species	63-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-119
14499627-1	2003	Aberrant upregulation of COX-2 enzyme resulting in accumulation of PGE2 in a cancer cell environment is a marker for progression of many cancers, including breast cancer.	Dinoprostone	67-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-30
14499627-5	2003	The elevated PGE2 production by metastatic cancer cells was due to COX-2 activity since dual COX-1/2 inhibitor indomethacin and selective COX-2 inhibitor NS-398 equally suppressed both basal and inducible (by IFN-gamma/LPS or Ca2+-ionophores) PGE2 accumulation.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	154-160	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-72
14499627-5	2003	The elevated PGE2 production by metastatic cancer cells was due to COX-2 activity since dual COX-1/2 inhibitor indomethacin and selective COX-2 inhibitor NS-398 equally suppressed both basal and inducible (by IFN-gamma/LPS or Ca2+-ionophores) PGE2 accumulation.	Dinoprostone	13-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-72
14499627-5	2003	The elevated PGE2 production by metastatic cancer cells was due to COX-2 activity since dual COX-1/2 inhibitor indomethacin and selective COX-2 inhibitor NS-398 equally suppressed both basal and inducible (by IFN-gamma/LPS or Ca2+-ionophores) PGE2 accumulation.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	154-160	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	138-143
14499627-5	2003	The elevated PGE2 production by metastatic cancer cells was due to COX-2 activity since dual COX-1/2 inhibitor indomethacin and selective COX-2 inhibitor NS-398 equally suppressed both basal and inducible (by IFN-gamma/LPS or Ca2+-ionophores) PGE2 accumulation.	Dinoprostone	13-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	138-143
14499627-5	2003	The elevated PGE2 production by metastatic cancer cells was due to COX-2 activity since dual COX-1/2 inhibitor indomethacin and selective COX-2 inhibitor NS-398 equally suppressed both basal and inducible (by IFN-gamma/LPS or Ca2+-ionophores) PGE2 accumulation.	Dinoprostone	243-247	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-72
14499627-5	2003	The elevated PGE2 production by metastatic cancer cells was due to COX-2 activity since dual COX-1/2 inhibitor indomethacin and selective COX-2 inhibitor NS-398 equally suppressed both basal and inducible (by IFN-gamma/LPS or Ca2+-ionophores) PGE2 accumulation.	Indomethacin	111-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-72
14584890-2	2003	Significantly higher BMD was found in users of relative COX-2 selective NSAIDs with aspirin (COX-2/ASA) compared with nonusers.	Aspirin	84-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-61
14631309-1	2003	Non-steroidal anti-inflammatory drugs (NSAIDs) reduce prostaglandin synthesis by inhibiting cyclo-oxygenase 1 (COX-1) and/or cyclo-oxygenase 2 (COX-2).	Prostaglandins	54-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	144-149
14584890-7	2003	Production of prostaglandins associated with bone loss is primarily mediated through the COX-2 pathway.	Prostaglandins	14-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-94
14584890-2	2003	Significantly higher BMD was found in users of relative COX-2 selective NSAIDs with aspirin (COX-2/ASA) compared with nonusers.	Aspirin	84-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-98
14584890-2	2003	Significantly higher BMD was found in users of relative COX-2 selective NSAIDs with aspirin (COX-2/ASA) compared with nonusers.	Aspirin	99-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-61
14584890-12	2003	RESULTS: After adjustment for possible confounders, current use of relative COX-2 selective NSAIDs with aspirin was associated with higher BMD at the whole body (4.2%, 1.2-7.3 CI) and total hip (4.6%, 0.5-8.8 CI) by DXA and at both trabecular (34.1%, 15.4-52.7 CI) and cortical spine (12.8%, 2.3-23.3 CI) by quantitative computed tomography.	Aspirin	104-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-81
14506383-3	2003	While it is well proven that COX-2 overexpression is a central event in colorectal carcinogenesis, that prostaglandins (PGs) can contribute to tumorigenesis, and that COX-2 selective inhibitors are active chemopreventive agents, the molecular mechanisms by which NSAIDs exert their chemopreventive effect is not fully understood.	Prostaglandins	120-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	167-172
14584890-13	2003	CONCLUSIONS: Our data suggest that the combination of relative COX-2 selective NSAIDs and aspirin is associated with higher BMD at multiple skeletal sites in men and women.	Aspirin	90-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-68
12969226-2	2003	Whether COX-2 is up-regulated in areca quid (AQ) related oral squamous cell carcinoma (OSCC) is unknown and the potential of AQ ingredients to induce COX-2 expression has not been studied.	aq	45-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	8-13
14606784-0	2003	Evaluation of meloxicam (A cox-2 inhibitor) for management of postoperative endodontic pain: a double-blind placebo-controlled study.	Meloxicam	14-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-32
12969226-2	2003	Whether COX-2 is up-regulated in areca quid (AQ) related oral squamous cell carcinoma (OSCC) is unknown and the potential of AQ ingredients to induce COX-2 expression has not been studied.	aq	125-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	150-155
12969226-4	2003	The COX-2 mRNA and protein induction potential of AQ ingredients were analyzed by real-time RT-PCR and Western blotting in normal human oral keratinocyte (NHOK).	aq	50-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
12969226-8	2003	Hydroxychavicol induced COX-2 mRNA and protein expression in NHOK.	2-hydroxychavicol	0-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
12969226-10	2003	Hydroxychavicol, a unique ingredient in AQ, induced COX-2 expression in NHOK, which highlighted early involvement of COX-2 in AQ-associated oral oncogenesis.	2-hydroxychavicol	0-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-57
12969226-10	2003	Hydroxychavicol, a unique ingredient in AQ, induced COX-2 expression in NHOK, which highlighted early involvement of COX-2 in AQ-associated oral oncogenesis.	2-hydroxychavicol	0-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-122
12969226-10	2003	Hydroxychavicol, a unique ingredient in AQ, induced COX-2 expression in NHOK, which highlighted early involvement of COX-2 in AQ-associated oral oncogenesis.	aq	126-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-122
14599481-9	2003	By contrast ROS formation by LD50 concentrations of Cu(II), Ni(II), Co(II) or dichromate [Cr(VI)] were not affected by uncouplers or glycolytic substrates.	Reactive Oxygen Species	12-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-74
14599481-14	2003	In conclusion, lysosomes are sites of cytotoxic ROS formation with redox transition metals (CuII, CrVI, NiII, CoII) whereas mitochondria are the ROS sites for non-redox or poor redox cycling transition metals (CdII, HgII, AsIII).	Reactive Oxygen Species	48-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-114
12835322-4	2003	In several cell lines, mPGES-2 promoted PGE2 production via both COX-1 and COX-2 in the immediate and delayed responses with modest COX-2 preference.	Dinoprostone	40-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
14633464-1	2003	OBJECTIVE: To study the relationship between COX-2 expression in esophageal cancer cell (EC/CUHK-1) and mitomycin C (MMC) treatment.	Mitomycin	117-120	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-50
14633464-8	2003	CONCLUSIONS: The COX-2 expression showed coincidence up-regulation according to the MMC-induced anti-apoptosis function activation in esophageal cancer cells, and the process was at least partly associated with Rb phosphorylation and p53 accumulation.	Rubidium	211-213	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22
14633464-9	2003	It is implied that COX-2 may be a protecting factor in MMC induced esophageal cancer cell apoptosis, and the use of COX-2 inhibitor as an enhancer for esophageal cancer chemotherapy may be reasonable.	Mitomycin	55-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-24
14633464-1	2003	OBJECTIVE: To study the relationship between COX-2 expression in esophageal cancer cell (EC/CUHK-1) and mitomycin C (MMC) treatment.	Mitomycin	104-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-50
12960371-1	2003	In addition to inhibiting cyclooxygenase (COX)-1-derived prostanoid biosynthesis, aspirin acetylates COX-2, enabling the conversion of arachidonic acid to 15(R)-epi lipoxin A4, or aspirin-triggered lipoxin (ATL).	Aspirin	82-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-106
12971747-2	2003	Five nitrogen atoms complete the coordination sphere of the Co(II) ion, showing a distorted trigonal bipyramid geometry.	Nitrogen	5-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-66
12968887-0	2003	Synthesis of antimalarial yingzhaosu A analogues by the peroxidation of dienes with Co(II)/O2/Et3SiH.	yingzhaosu A	26-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-93
12968887-0	2003	Synthesis of antimalarial yingzhaosu A analogues by the peroxidation of dienes with Co(II)/O2/Et3SiH.	dienes	72-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-93
12968887-0	2003	Synthesis of antimalarial yingzhaosu A analogues by the peroxidation of dienes with Co(II)/O2/Et3SiH.	triethylsilylhydride	94-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-93
12968887-1	2003	Co(II)-catalyzed peroxidation of dienes including (S)-limonene in the presence of molecular oxygen and triethylsilane provided in each case the corresponding 2,3-dioxabicyclo[3.3.1]nonane derivatives via the intramolecular cyclization of the unsaturated peroxy radical intermediates.	dienes	33-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
12968887-1	2003	Co(II)-catalyzed peroxidation of dienes including (S)-limonene in the presence of molecular oxygen and triethylsilane provided in each case the corresponding 2,3-dioxabicyclo[3.3.1]nonane derivatives via the intramolecular cyclization of the unsaturated peroxy radical intermediates.	Limonene	50-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
12968887-1	2003	Co(II)-catalyzed peroxidation of dienes including (S)-limonene in the presence of molecular oxygen and triethylsilane provided in each case the corresponding 2,3-dioxabicyclo[3.3.1]nonane derivatives via the intramolecular cyclization of the unsaturated peroxy radical intermediates.	Oxygen	92-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
12963019-3	2003	cDNA array analysis revealed that sodium butyrate augmented ICAM-1 mRNA expression, while it inhibited IL-6 and COX-2 expression in response to LPS stimulation.	Butyric Acid	34-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-117
12960371-1	2003	In addition to inhibiting cyclooxygenase (COX)-1-derived prostanoid biosynthesis, aspirin acetylates COX-2, enabling the conversion of arachidonic acid to 15(R)-epi lipoxin A4, or aspirin-triggered lipoxin (ATL).	Arachidonic Acid	135-151	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-106
12968887-1	2003	Co(II)-catalyzed peroxidation of dienes including (S)-limonene in the presence of molecular oxygen and triethylsilane provided in each case the corresponding 2,3-dioxabicyclo[3.3.1]nonane derivatives via the intramolecular cyclization of the unsaturated peroxy radical intermediates.	triethylsilane	103-117	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
12960371-1	2003	In addition to inhibiting cyclooxygenase (COX)-1-derived prostanoid biosynthesis, aspirin acetylates COX-2, enabling the conversion of arachidonic acid to 15(R)-epi lipoxin A4, or aspirin-triggered lipoxin (ATL).	15(r)-epi lipoxin a4	155-175	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-106
12960371-1	2003	In addition to inhibiting cyclooxygenase (COX)-1-derived prostanoid biosynthesis, aspirin acetylates COX-2, enabling the conversion of arachidonic acid to 15(R)-epi lipoxin A4, or aspirin-triggered lipoxin (ATL).	Aspirin	180-187	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-106
12968887-1	2003	Co(II)-catalyzed peroxidation of dienes including (S)-limonene in the presence of molecular oxygen and triethylsilane provided in each case the corresponding 2,3-dioxabicyclo[3.3.1]nonane derivatives via the intramolecular cyclization of the unsaturated peroxy radical intermediates.	2,3-dioxabicyclo[3.3.1]nonane derivatives	158-199	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
12960371-1	2003	In addition to inhibiting cyclooxygenase (COX)-1-derived prostanoid biosynthesis, aspirin acetylates COX-2, enabling the conversion of arachidonic acid to 15(R)-epi lipoxin A4, or aspirin-triggered lipoxin (ATL).	Lipoxins	165-172	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-106
12968887-1	2003	Co(II)-catalyzed peroxidation of dienes including (S)-limonene in the presence of molecular oxygen and triethylsilane provided in each case the corresponding 2,3-dioxabicyclo[3.3.1]nonane derivatives via the intramolecular cyclization of the unsaturated peroxy radical intermediates.	unsaturated peroxy radical	242-268	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
12960371-1	2003	In addition to inhibiting cyclooxygenase (COX)-1-derived prostanoid biosynthesis, aspirin acetylates COX-2, enabling the conversion of arachidonic acid to 15(R)-epi lipoxin A4, or aspirin-triggered lipoxin (ATL).	15-epi-lipoxin A4	207-210	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-106
12960371-10	2003	These findings suggests that (i) aspirin and NCX-4016 trigger ATL formation in humans, (ii) celecoxib inhibits ATL formation and exacerbates the mucosal injury caused by low doses of aspirin, and (iii) the NO-donating moiety of NCX-4016 protects the gastric mucosa even in the presence of suppression of COX-1 and COX-2.	Celecoxib	92-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	314-319
12954051-1	2003	A series of 1,5-diarylpyrazoles having a substituted benzenesulfonamide moiety as pharmacophore was synthesized and evaluated for cyclooxygenase (COX-1/COX-2) inhibitory activities.	1,5-diarylpyrazoles	12-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-157
12954051-2	2003	Through SAR and molecular modeling, it was found that fluorine substitution on the benzenesulfonamide moiety along with an electron-donating group at the 4-position of the 5-aryl ring yielded selectivity as well as potency for COX-2 inhibition in vitro.	Fluorine	54-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	227-232
12952446-3	2003	Methylation of monomeric {Fe0(N2)-} and {Co0(N2)-} species successfully derivatizes the beta-N atom of the coordinated N2 ligand and affords the diazenido products {FeII(N2Me)} and {CoII(N2Me)}, respectively.	fe0(n2)	26-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	182-186
12954051-2	2003	Through SAR and molecular modeling, it was found that fluorine substitution on the benzenesulfonamide moiety along with an electron-donating group at the 4-position of the 5-aryl ring yielded selectivity as well as potency for COX-2 inhibition in vitro.	benzenesulfonamide	83-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	227-232
12952446-3	2003	Methylation of monomeric {Fe0(N2)-} and {Co0(N2)-} species successfully derivatizes the beta-N atom of the coordinated N2 ligand and affords the diazenido products {FeII(N2Me)} and {CoII(N2Me)}, respectively.	co0(n2)	41-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	182-186
12954051-4	2003	Among the sodium salts tested in vivo, 10, the propionyl analogue of 3, showed excellent antiinflammatory activity and therefore represents a new lead structure for the development of injectable COX-2 specific inhibitors.	sodium salts	10-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	195-200
12952446-3	2003	Methylation of monomeric {Fe0(N2)-} and {Co0(N2)-} species successfully derivatizes the beta-N atom of the coordinated N2 ligand and affords the diazenido products {FeII(N2Me)} and {CoII(N2Me)}, respectively.	beta-n	88-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	182-186
12950415-3	2003	The putative chemopreventive actions include the inhibition of inflammatory cascades and/or reactions involved in cell growth and proliferation, such as cyclo-oxygenase (COX-1 and COX-2), which regulate cell proliferation through the formation of prostaglandins; lipoxygenase; nuclear factor kappaB (NFkappaB), responsible for the subsequent expression of pro-inflammatory molecules; MAP kinases and Bcl-2, as well as the activation of apoptotic processes, such as the stimulation of intestinal sphingomyelinase.	Prostaglandins	247-261	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	180-185
12952446-3	2003	Methylation of monomeric {Fe0(N2)-} and {Co0(N2)-} species successfully derivatizes the beta-N atom of the coordinated N2 ligand and affords the diazenido products {FeII(N2Me)} and {CoII(N2Me)}, respectively.	diazenido	145-154	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	182-186
14518138-3	2003	Notably, the capped porphyrin 5 was able to inhibit the oxidation of Co(II) to Co(III), whereas compound 7 did it only partially.	porphyrin 5	20-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-75
14521730-1	2003	OBJECTIVE: To investigate the effect of cyclooxygenase-2 antisense oligodeoxynucleotides (COX-2 AS-ODNs) on the angiogenesis in pancreatic carcinoma and to evaluate the intermediary effect of prostaglandin 2 in this process.	Oligodeoxyribonucleotides	67-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-95
12944651-1	2003	A trimeric compound containing Co(II) is described, namely tris[mu-2-[3-(dimethylamino)propylimino]propane-1-thiolato]tricobalt(II) chloride bis(hexafluorophosphate), [Co(3)(C(10)H(21)N(2)S)(3)]Cl(PF(6))(2).	co(3)	168-173	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-37
12944651-1	2003	A trimeric compound containing Co(II) is described, namely tris[mu-2-[3-(dimethylamino)propylimino]propane-1-thiolato]tricobalt(II) chloride bis(hexafluorophosphate), [Co(3)(C(10)H(21)N(2)S)(3)]Cl(PF(6))(2).	n(2)s)(3)]cl	184-196	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-37
12944651-1	2003	A trimeric compound containing Co(II) is described, namely tris[mu-2-[3-(dimethylamino)propylimino]propane-1-thiolato]tricobalt(II) chloride bis(hexafluorophosphate), [Co(3)(C(10)H(21)N(2)S)(3)]Cl(PF(6))(2).	pf(6))	197-203	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-37
12975714-7	2003	The average total daily dose of COX-2 inhibitor was 219.2 mg for celecoxib and 25.23 mg for rofecoxib.	Celecoxib	65-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-37
12975714-7	2003	The average total daily dose of COX-2 inhibitor was 219.2 mg for celecoxib and 25.23 mg for rofecoxib.	rofecoxib	92-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-37
14528488-1	2003	In this study we describe the synthesis of two novel 4-phenyl-and 4-(2-chlorophenyl)-6-(5-chloro-2-oxo-3H-benzoxazol-7-yl)-3(2H)-pyridazinone derivatives (compounds 8a and b) and their testing as inhibitors of cyclooxygenases (COX-1 and COX-2).	4-phenyl-and 4-(2-chlorophenyl)-6-(5-chloro-2-oxo-3h-benzoxazol-7-yl)-3(2h)-pyridazinone	53-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	237-242
14528491-0	2003	Synthesis and effects on the COX-1 and COX-2 activity in human whole blood ex vivo of derivatives containing the [1]benzothienol-[3, 2-d]pyrimidin-4-one heterocyclic system.	[1]benzothienol-[3, 2-d]pyrimidin-4-one	113-152	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-44
14500353-0	2003	Inhibition of COX-2 in colon cancer cell lines by celecoxib increases the nuclear localization of active p53.	Celecoxib	50-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
12927860-0	2003	Computer-aided design of non sulphonyl COX-2 inhibitors: an improved comparative molecular field analysis incorporating additional descriptors and comparative molecular similarity indices analysis of 1,3-diarylisoindole derivatives.	1,3-diarylisoindole	200-219	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-44
12927860-1	2003	A set of thirty five molecules of 1,3-diaryl-4,5,6,7-tetrahydro-2H-isoindoles endowed with selective COX-2 inhibitory activity was analyzed using comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA).	1,3-diaryl-4,5,6,7-tetrahydro-2h-isoindoles	34-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-106
12927860-5	2003	FlexX was used to find out the binding orientation of this new class of 1,3-diaryl isoindoles in the active site of COX-2.	1,3-diaryl isoindoles	72-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-121
14500353-14	2003	Inhibition of COX-2 by celecoxib appears to alleviate this effect on p53 by reducing electrophilic PG synthesis.	Celecoxib	23-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
14500353-3	2003	Electrophilic prostaglandins (PGs) are known to sequester and inactivate p53 in the cytoplasm, an effect that is likely to occur when cyclooxygenase (COX)-2 levels become elevated during colon carcinogenesis.	Prostaglandins	14-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-156
14500353-14	2003	Inhibition of COX-2 by celecoxib appears to alleviate this effect on p53 by reducing electrophilic PG synthesis.	Prostaglandins	99-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
14500353-3	2003	Electrophilic prostaglandins (PGs) are known to sequester and inactivate p53 in the cytoplasm, an effect that is likely to occur when cyclooxygenase (COX)-2 levels become elevated during colon carcinogenesis.	Prostaglandins	30-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-156
14500353-15	2003	Thus, COX-2 inhibition of electrophilic PG formation appears to protect p53 tumor suppressor function.	Prostaglandins	40-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	6-11
14511332-3	2003	In particular COX-2 was demonstrated to be crucial for PG-synthesis in inflammation.	Prostaglandins	55-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
12966366-8	2003	Maximal plasma concentrations of diclofenac after oral administration of aceclofenac (0.39 micromol/L) or diclofenac (1.28 micromol/L) were sufficient for a greater than 97% inhibition of COX-2 (50% inhibitory concentration, 0.024 micromol/L) and a 46% (aceclofenac treatment) or 82% inhibition (diclofenac treatment) of COX-1 (50% inhibitory concentration, 0.43 micromol/L).	Diclofenac	33-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	188-193
12966366-8	2003	Maximal plasma concentrations of diclofenac after oral administration of aceclofenac (0.39 micromol/L) or diclofenac (1.28 micromol/L) were sufficient for a greater than 97% inhibition of COX-2 (50% inhibitory concentration, 0.024 micromol/L) and a 46% (aceclofenac treatment) or 82% inhibition (diclofenac treatment) of COX-1 (50% inhibitory concentration, 0.43 micromol/L).	aceclofenac	73-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	188-193
12966366-8	2003	Maximal plasma concentrations of diclofenac after oral administration of aceclofenac (0.39 micromol/L) or diclofenac (1.28 micromol/L) were sufficient for a greater than 97% inhibition of COX-2 (50% inhibitory concentration, 0.024 micromol/L) and a 46% (aceclofenac treatment) or 82% inhibition (diclofenac treatment) of COX-1 (50% inhibitory concentration, 0.43 micromol/L).	Diclofenac	106-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	188-193
12966366-8	2003	Maximal plasma concentrations of diclofenac after oral administration of aceclofenac (0.39 micromol/L) or diclofenac (1.28 micromol/L) were sufficient for a greater than 97% inhibition of COX-2 (50% inhibitory concentration, 0.024 micromol/L) and a 46% (aceclofenac treatment) or 82% inhibition (diclofenac treatment) of COX-1 (50% inhibitory concentration, 0.43 micromol/L).	Diclofenac	106-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	188-193
12966366-11	2003	Although 100 mg aceclofenac yielded diclofenac concentrations substantially lower than 75 mg diclofenac, these were sufficient for a sustained block of COX-2 but caused a minor and shorter inhibition of COX-1 than 75 mg diclofenac.	aceclofenac	16-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-157
12966366-12	2003	In conclusion, both COX-1-sparing and COX-2-inhibitory actions of aceclofenac may rest in its limited but sustained biotransformation to diclofenac.	aceclofenac	66-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-43
14611112-4	2003	RESULTS: LPS significantly increased NO2-; PGE2 and TNF-alpha levels by 24 h. Quantitative real-time PCR demonstrated a dose-dependent reduction in the expression of COX-2 in the presence of increasing doses of L-NAME.	Nitrogen Dioxide	37-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	166-171
14611112-4	2003	RESULTS: LPS significantly increased NO2-; PGE2 and TNF-alpha levels by 24 h. Quantitative real-time PCR demonstrated a dose-dependent reduction in the expression of COX-2 in the presence of increasing doses of L-NAME.	Dinoprostone	43-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	166-171
14611112-4	2003	RESULTS: LPS significantly increased NO2-; PGE2 and TNF-alpha levels by 24 h. Quantitative real-time PCR demonstrated a dose-dependent reduction in the expression of COX-2 in the presence of increasing doses of L-NAME.	NG-Nitroarginine Methyl Ester	211-217	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	166-171
15040874-7	2003	Reactions mediated by COX-2 form reactive oxygen species that can directly induce the oxidation of DNA or instigate the bioactivation of carcinogens.	Reactive Oxygen Species	33-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-27
15040874-8	2003	Prostaglandin E2, a byproduct of COX-2-mediated arachidonic acid metabolism, exhibits several biologic actions that have been shown to promote tumorigenesis and tumor progression.	Dinoprostone	0-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-38
15040874-8	2003	Prostaglandin E2, a byproduct of COX-2-mediated arachidonic acid metabolism, exhibits several biologic actions that have been shown to promote tumorigenesis and tumor progression.	Arachidonic Acid	48-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-38
12888902-2	2003	In this study, we investigated the effect of a selective COX-2 inhibitor, celecoxib, on growth and apoptosis induction of four human head and neck carcinoma cell lines, SCC25, KB, HSG and HSY, in comparison with frequently used COX inhibitor sulindac.	Celecoxib	74-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-62
13679172-1	2003	A number of 5-aryl-1-[4-(methylsulfonyl)-phenyl]-1H-pyrazoles and 4-(5-aryl-1H-pyrazol-1-yl)benzenesulfonamides 3, 4, 5, 6, analogues of the COX-2 selective inhibitor celecoxib (celebrex), were synthesized.	5-aryl-1-[4-(methylsulfonyl)-phenyl]-1h-pyrazoles	12-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	141-146
13679172-1	2003	A number of 5-aryl-1-[4-(methylsulfonyl)-phenyl]-1H-pyrazoles and 4-(5-aryl-1H-pyrazol-1-yl)benzenesulfonamides 3, 4, 5, 6, analogues of the COX-2 selective inhibitor celecoxib (celebrex), were synthesized.	4-(5-aryl-1h-pyrazol-1-yl)benzenesulfonamides	66-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	141-146
15038780-5	2003	Dexamethasone significantly reduced IL-1 beta, IL-6, COX-2, and MMP-1 expression at high cell density.	Dexamethasone	0-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-58
12888902-7	2003	The PGE2 production and COX-2 expression were inhibited more efficiently by celecoxib than by sulindac.	Celecoxib	76-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
12888902-7	2003	The PGE2 production and COX-2 expression were inhibited more efficiently by celecoxib than by sulindac.	Sulindac	94-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
12888902-13	2003	These findings indicated that a selective COX-2 inhibitor celecoxib inhibits cell proliferation, induces apoptosis and augments sensitivity to anticancer drugs in human head and neck carcinoma cells.	Celecoxib	58-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47
12975479-6	2003	15d-PGJ2 is detectable as a minor product of COX-2 in human urine.	15-deoxy-delta(12,14)-prostaglandin J2	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-50
12923398-1	2003	BACKGROUND: Cyclo-oxygenase (COX)-2 isoform appears to be a major source of the vasodilator, prostacyclin.	Epoprostenol	93-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-35
14562919-3	2003	Metal [M = V(III), Cr(III), Mn(II), Fe(III), Ni(II), Cu(II), Zn(II) and Co(II)] diethyldithiocarbamates (DEDTC) were synthesized by the reaction of sodium diethyldithiocarbamate with metal chloride in dichloromethane/water mixture.	Metals	0-5	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-78
14562919-9	2003	The order of percent nitrification inhibition in soil by metal diethyldithiocarbamates was: Zn(II) &gt; Mn(II) &gt; Fe(III) &gt; Cr(III) &gt; V(III) &gt; Co(II) &gt; Ni(II) &gt; Cu(II).	Metals	57-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	154-160
14562919-9	2003	The order of percent nitrification inhibition in soil by metal diethyldithiocarbamates was: Zn(II) &gt; Mn(II) &gt; Fe(III) &gt; Cr(III) &gt; V(III) &gt; Co(II) &gt; Ni(II) &gt; Cu(II).	Ditiocarb	63-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	154-160
12923398-12	2003	CONCLUSION: COX-2 inhibition with the prodrug, parecoxib, diminishes the acetylcholine-induced vasodilatation in the forearm circulation of patients with essential hypertension.	parecoxib	47-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-17
12923398-12	2003	CONCLUSION: COX-2 inhibition with the prodrug, parecoxib, diminishes the acetylcholine-induced vasodilatation in the forearm circulation of patients with essential hypertension.	Acetylcholine	73-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-17
14623550-4	2003	The prostaglandin PGE2 increases intracellular cAMP levels and stimulates estrogen biosynthesis, and previous studies in our laboratories have shown a strong linear association between aromatase (CYP19) expression and expression of the cyclooxygenases (COX-1 and COX-2) in breast cancer specimens.	Prostaglandins	4-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	263-268
12813143-8	2003	The findings indicate that COX-2 specific mechanisms are responsible for the exercise-induced increase in prostaglandin synthesis, and that increase in tissue prostaglandin plays an important role for blood flow in peritendinous connective tissue during physical loading in vivo.	Prostaglandins	106-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-32
14582702-6	2003	The expression of the COX-2 protein was immunohistochemically examined on formalin-fixed and paraffin-embedded tissue sections using an anti-COX-2 antibody and an avidin-biotin complex method.	Formaldehyde	74-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-27
14582702-6	2003	The expression of the COX-2 protein was immunohistochemically examined on formalin-fixed and paraffin-embedded tissue sections using an anti-COX-2 antibody and an avidin-biotin complex method.	Paraffin	93-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-27
14582702-6	2003	The expression of the COX-2 protein was immunohistochemically examined on formalin-fixed and paraffin-embedded tissue sections using an anti-COX-2 antibody and an avidin-biotin complex method.	avidin-biotin	163-176	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-27
14623550-4	2003	The prostaglandin PGE2 increases intracellular cAMP levels and stimulates estrogen biosynthesis, and previous studies in our laboratories have shown a strong linear association between aromatase (CYP19) expression and expression of the cyclooxygenases (COX-1 and COX-2) in breast cancer specimens.	Dinoprostone	18-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	263-268
12912810-2	2003	The present study demonstrates, however, that depending on prevailing conditions, COX-2-derived prostanoids may also inhibit VSMC proliferation.	Prostaglandins	96-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
14594936-4	2003	Previous clinical trials have shown the effectiveness of the following: polyprenoic acid (acyclic retinoid) for hepatocellular carcinoma; tamoxifen for breast cancer; retinoic acids for head and neck tumor; and aspirin, a COX-2 inhibitor, for colorectal cancer.	Aspirin	211-218	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	222-227
12949405-1	2003	Cyclooxygenase (COX) enzymes catalyze the synthesis of prostaglandins and exist as two isoforms, COX-1 and COX-2.	Prostaglandins	55-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-112
12924888-6	2003	Recombination to the ground state followed, with a rate constant k(b) approximately 4.5 x 10(8) s(-)(1) (tau(b) approximately 2.2 ns), for both Ru(II)-BQ and Ru(II)-BQ-Co(III) with no indication of a charge shift to generate the reduced Co(II) moiety.	ru(ii)-bq	144-153	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	237-243
12963440-5	2003	The Co(II) complexes of the investigated 3-phenyl-4-arylazo-5-pyrazolones (I-IV) have been prepared and characterized by elemental and thermal analyses as well as by IR, UV-Vis, electronic transition, potentiometric, conductimetric and magnetic measurements.	3-phenyl-4-arylazo-5-pyrazolones	41-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
12912810-4	2003	This effect was abolished by NS-398, a selective COX-2 inhibitor.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	29-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-54
12924888-6	2003	Recombination to the ground state followed, with a rate constant k(b) approximately 4.5 x 10(8) s(-)(1) (tau(b) approximately 2.2 ns), for both Ru(II)-BQ and Ru(II)-BQ-Co(III) with no indication of a charge shift to generate the reduced Co(II) moiety.	ru(ii)-bq-co(iii)	158-175	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	237-243
12924913-1	2003	Two novel coordination polymers of Co(II) with dicyanamide (dca) were obtained by the addition of ancillary ligands of pyrazine dioxide (pzdo) and 2-methyl pyrazine dioxide (mpdo) into the Co-dca binary system, respectively.	Polymers	23-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40
12912810-10	2003	The effects of NO donors were prevented when COX-2 activity was inhibited with NS-398.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	79-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-50
12924913-1	2003	Two novel coordination polymers of Co(II) with dicyanamide (dca) were obtained by the addition of ancillary ligands of pyrazine dioxide (pzdo) and 2-methyl pyrazine dioxide (mpdo) into the Co-dca binary system, respectively.	trimethylsulfonium dicyanamide	47-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40
12912810-11	2003	CONCLUSIONS: The COX-2-dependent proliferative response of VSMCs to TNF was modulated in an NO-dependent manner, and PGI2 derived from COX-2 might contribute to the antiproliferative effect of NO donors.	Epoprostenol	117-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-140
12924913-1	2003	Two novel coordination polymers of Co(II) with dicyanamide (dca) were obtained by the addition of ancillary ligands of pyrazine dioxide (pzdo) and 2-methyl pyrazine dioxide (mpdo) into the Co-dca binary system, respectively.	dichloroacetylene	60-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40
12924913-1	2003	Two novel coordination polymers of Co(II) with dicyanamide (dca) were obtained by the addition of ancillary ligands of pyrazine dioxide (pzdo) and 2-methyl pyrazine dioxide (mpdo) into the Co-dca binary system, respectively.	Pyrazine, 1,4-dioxide	119-135	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40
12924913-1	2003	Two novel coordination polymers of Co(II) with dicyanamide (dca) were obtained by the addition of ancillary ligands of pyrazine dioxide (pzdo) and 2-methyl pyrazine dioxide (mpdo) into the Co-dca binary system, respectively.	pzdo	137-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40
12924913-1	2003	Two novel coordination polymers of Co(II) with dicyanamide (dca) were obtained by the addition of ancillary ligands of pyrazine dioxide (pzdo) and 2-methyl pyrazine dioxide (mpdo) into the Co-dca binary system, respectively.	2-methyl pyrazine dioxide	147-172	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40
12924878-3	2003	This precursor proves to be an effective transmetallating agent, as evidenced by its reaction with the divalent halides FeCl(2) and CoX(2) (X = Cl, I) to produce the monomeric, 4-coordinate, high-spin derivatives [PhBP(iPr)(3)]FeCl (2) and [PhBP(iPr)(3)]CoX (X = Cl (3), I (4)) in good yield.	halides	112-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-138
12924913-1	2003	Two novel coordination polymers of Co(II) with dicyanamide (dca) were obtained by the addition of ancillary ligands of pyrazine dioxide (pzdo) and 2-methyl pyrazine dioxide (mpdo) into the Co-dca binary system, respectively.	mpdo	174-178	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40
12924913-1	2003	Two novel coordination polymers of Co(II) with dicyanamide (dca) were obtained by the addition of ancillary ligands of pyrazine dioxide (pzdo) and 2-methyl pyrazine dioxide (mpdo) into the Co-dca binary system, respectively.	co-dca	189-195	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40
12916108-7	2003	The neutral complexes of Co(II)(tpp) with C(60), C(60)(CN)(2), C(70), and Cr(0)(C(6)H(6))(2), as well as the crystal structures of [Co(II)(tpp)](C(60)).2.5 C(6)H(4)Cl(2), [Co(II)(tpp)](C(70)).	Chromium	74-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-31
18969136-3	2003	The extraction of copper is affected by Fe(II), Mn(II), Zn(II), Ni(II) and Co(II) while only Fe(II) interferes in the lead determination.	Copper	18-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-81
12916108-4	2003	3.3 C(6)H(4)Cl(2) and [[Cr(I)(C(6)H(6))(2)] (.+)](2)[Co(II)(tpp)[C(60)(CN)(2)]](-)[C(60)(CN)(2) (.-)]).3 C(6)H(4)Cl(2) are presented.	tetraphenylporphine sulfonate	60-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-59
12916108-7	2003	The neutral complexes of Co(II)(tpp) with C(60), C(60)(CN)(2), C(70), and Cr(0)(C(6)H(6))(2), as well as the crystal structures of [Co(II)(tpp)](C(60)).2.5 C(6)H(4)Cl(2), [Co(II)(tpp)](C(70)).	tetraphenylporphine sulfonate	32-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-31
12916108-5	2003	The essentially shortened Co.C(fullerene) bond lengths of 2.28-2.32 A in these complexes indicate the formation of sigma-bonded [Co(II)(tpp)][fullerene](-) anions, which are diamagnetic.	Fullerenes	31-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-135
12916108-8	2003	1.3 CHCl(3).0.2 C(6)H(6), and [Cr(0)(C(6)H(6))(2)][Co(II)(tpp)] are discussed.	tetraphenylporphine sulfonate	58-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-57
14524083-0	2003	[Selective COX 2 inhibitor rofecoxib.	rofecoxib	27-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-16
12916108-5	2003	The essentially shortened Co.C(fullerene) bond lengths of 2.28-2.32 A in these complexes indicate the formation of sigma-bonded [Co(II)(tpp)][fullerene](-) anions, which are diamagnetic.	Fullerenes	142-151	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-135
12916108-7	2003	The neutral complexes of Co(II)(tpp) with C(60), C(60)(CN)(2), C(70), and Cr(0)(C(6)H(6))(2), as well as the crystal structures of [Co(II)(tpp)](C(60)).2.5 C(6)H(4)Cl(2), [Co(II)(tpp)](C(70)).	tetraphenylporphine sulfonate	32-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-31
12895099-2	2003	The isostructural Co(II) and the Ni(II) complexes show octahedral geometries around the metal ions with the coordination sites occupied by the pyridyl nitrogen atoms and the thioether sulfur atoms of the ligand and cis coordination of the halide ions.	Metals	88-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-24
12895099-2	2003	The isostructural Co(II) and the Ni(II) complexes show octahedral geometries around the metal ions with the coordination sites occupied by the pyridyl nitrogen atoms and the thioether sulfur atoms of the ligand and cis coordination of the halide ions.	Aminopyridines	143-159	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-24
12895099-2	2003	The isostructural Co(II) and the Ni(II) complexes show octahedral geometries around the metal ions with the coordination sites occupied by the pyridyl nitrogen atoms and the thioether sulfur atoms of the ligand and cis coordination of the halide ions.	thioether sulfur	174-190	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-24
12895099-2	2003	The isostructural Co(II) and the Ni(II) complexes show octahedral geometries around the metal ions with the coordination sites occupied by the pyridyl nitrogen atoms and the thioether sulfur atoms of the ligand and cis coordination of the halide ions.	halide	239-245	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-24
12874188-8	2003	The inducible isoform of cyclooxygenase in platelets, COX-2, has been suggested to confer aspirin resistance.	Aspirin	90-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-59
12898676-1	2003	Cobalt(II) complexes of poly(aryl ester) dendrimer porphyrins [(m-[Gn]TPP)Co(II)] (generation number n=0-4), in the presence of azobisisobutyronitrile (AIBN) at 60 degrees C, underwent alkenylation with several alkynes at the metal center.	Cobalt(2+)	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-81
12874188-9	2003	In fact, immunoreactive COX-2 was increased 16-fold in platelets at day 5 after CABG, but the COX-2 selective inhibitor celecoxib did not alter aspirin-resistant thromboxane formation.	Celecoxib	120-129	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-99
12898676-1	2003	Cobalt(II) complexes of poly(aryl ester) dendrimer porphyrins [(m-[Gn]TPP)Co(II)] (generation number n=0-4), in the presence of azobisisobutyronitrile (AIBN) at 60 degrees C, underwent alkenylation with several alkynes at the metal center.	poly(aryl ester	24-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-81
12889922-1	2003	A new type of cyano-bridged Co-W bimetallic assembly, CsI[{CoII(3-cyanopyridine)2}{WV(CN)8}].H2O was synthesized.	co-w	28-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-63
12889922-1	2003	A new type of cyano-bridged Co-W bimetallic assembly, CsI[{CoII(3-cyanopyridine)2}{WV(CN)8}].H2O was synthesized.	Water	93-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-63
12898676-1	2003	Cobalt(II) complexes of poly(aryl ester) dendrimer porphyrins [(m-[Gn]TPP)Co(II)] (generation number n=0-4), in the presence of azobisisobutyronitrile (AIBN) at 60 degrees C, underwent alkenylation with several alkynes at the metal center.	Porphyrins	51-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-81
12898676-2	2003	A complete inhibition of double-bond migration (secondary transformation) was observed for [(m-[Gn]TPP)Co(II)] (n=3 and 4), which gave [(m-[Gn]TPP)Co(III)-C(=CH(2))R] (n=3 and 4) exclusively.	[(m-[gn]tpp	91-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-110
12898676-2	2003	A complete inhibition of double-bond migration (secondary transformation) was observed for [(m-[Gn]TPP)Co(II)] (n=3 and 4), which gave [(m-[Gn]TPP)Co(III)-C(=CH(2))R] (n=3 and 4) exclusively.	[(m-[gn]tpp	135-146	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-110
12898676-2	2003	A complete inhibition of double-bond migration (secondary transformation) was observed for [(m-[Gn]TPP)Co(II)] (n=3 and 4), which gave [(m-[Gn]TPP)Co(III)-C(=CH(2))R] (n=3 and 4) exclusively.	co(iii)-c	147-156	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-110
12898676-3	2003	Overall reaction rates for [(m-[Gn]TPP)Co(II)] (n=0-3) were hardly dependent on the size of the dendritic substituents, while a notable retardation was observed for the largest dendrimer, [(m-[G4]TPP)Co(II)].	(m-[gn]tpp	28-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-46
12898676-3	2003	Overall reaction rates for [(m-[Gn]TPP)Co(II)] (n=0-3) were hardly dependent on the size of the dendritic substituents, while a notable retardation was observed for the largest dendrimer, [(m-[G4]TPP)Co(II)].	(m-[gn]tpp	28-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-45
12898676-3	2003	Overall reaction rates for [(m-[Gn]TPP)Co(II)] (n=0-3) were hardly dependent on the size of the dendritic substituents, while a notable retardation was observed for the largest dendrimer, [(m-[G4]TPP)Co(II)].	(m-[g4]tpp)	189-200	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-46
12898676-3	2003	Overall reaction rates for [(m-[Gn]TPP)Co(II)] (n=0-3) were hardly dependent on the size of the dendritic substituents, while a notable retardation was observed for the largest dendrimer, [(m-[G4]TPP)Co(II)].	(m-[g4]tpp)	189-200	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-45
12898676-4	2003	Mechanistic studies on double-bond migration with pure [(m-[Gn]TPP)Co(III)-C(=CH(2))Bu] (n=0-4) demonstrated that the secondary transformation involves participation of [(m-[Gn]TPP)Co(III)H] (n=0-4), derived from [(m-[Gn]TPP)Co(II)] and AIBN, rather than [(m-[Gn]TPP)Co(II)] alone.	[(m-[gn]tpp)	55-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	225-231
12898676-4	2003	Mechanistic studies on double-bond migration with pure [(m-[Gn]TPP)Co(III)-C(=CH(2))Bu] (n=0-4) demonstrated that the secondary transformation involves participation of [(m-[Gn]TPP)Co(III)H] (n=0-4), derived from [(m-[Gn]TPP)Co(II)] and AIBN, rather than [(m-[Gn]TPP)Co(II)] alone.	[(m-[gn]tpp)	55-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	225-232
12898676-4	2003	Mechanistic studies on double-bond migration with pure [(m-[Gn]TPP)Co(III)-C(=CH(2))Bu] (n=0-4) demonstrated that the secondary transformation involves participation of [(m-[Gn]TPP)Co(III)H] (n=0-4), derived from [(m-[Gn]TPP)Co(II)] and AIBN, rather than [(m-[Gn]TPP)Co(II)] alone.	m-[gn]tpp)	57-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	225-231
12898676-4	2003	Mechanistic studies on double-bond migration with pure [(m-[Gn]TPP)Co(III)-C(=CH(2))Bu] (n=0-4) demonstrated that the secondary transformation involves participation of [(m-[Gn]TPP)Co(III)H] (n=0-4), derived from [(m-[Gn]TPP)Co(II)] and AIBN, rather than [(m-[Gn]TPP)Co(II)] alone.	m-[gn]tpp)	57-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	225-232
12898676-4	2003	Mechanistic studies on double-bond migration with pure [(m-[Gn]TPP)Co(III)-C(=CH(2))Bu] (n=0-4) demonstrated that the secondary transformation involves participation of [(m-[Gn]TPP)Co(III)H] (n=0-4), derived from [(m-[Gn]TPP)Co(II)] and AIBN, rather than [(m-[Gn]TPP)Co(II)] alone.	m-[gn]tpp	57-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	225-231
12898676-4	2003	Mechanistic studies on double-bond migration with pure [(m-[Gn]TPP)Co(III)-C(=CH(2))Bu] (n=0-4) demonstrated that the secondary transformation involves participation of [(m-[Gn]TPP)Co(III)H] (n=0-4), derived from [(m-[Gn]TPP)Co(II)] and AIBN, rather than [(m-[Gn]TPP)Co(II)] alone.	m-[gn]tpp	57-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	225-232
12907325-0	2003	The gastrointestinal safety of the COX-2 selective inhibitor etoricoxib assessed by both endoscopy and analysis of upper gastrointestinal events.	Etoricoxib	61-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40
12902855-6	2003	Two specific COX-2 inhibitors, namely, rofecoxib (Vioxx) and celecoxib (Celebrex), both oral agents and FDA approved, have been shown preclinically and clinically to have efficacy comparable to that of NSAIDs for relief of pain and inflammation in osteoarthritis, with decreased risk of gastrointestinal damage.	rofecoxib	39-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
12890715-1	2003	(1) Unlike other nonsteroidal anti-inflammatory drugs that inhibit formation of cyclooxygenase (COX)-dependent eicosanoids, acetylation of COX-2 by aspirin switches eicosanoid biosynthesis from prostaglandin E(2) (PGE(2)) to 15-epi-lipoxin A(4) (15-epi-LXA(4) or aspirin-triggered lipoxin, ATL).	Aspirin	148-155	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-144
12902855-6	2003	Two specific COX-2 inhibitors, namely, rofecoxib (Vioxx) and celecoxib (Celebrex), both oral agents and FDA approved, have been shown preclinically and clinically to have efficacy comparable to that of NSAIDs for relief of pain and inflammation in osteoarthritis, with decreased risk of gastrointestinal damage.	rofecoxib	50-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
12902855-6	2003	Two specific COX-2 inhibitors, namely, rofecoxib (Vioxx) and celecoxib (Celebrex), both oral agents and FDA approved, have been shown preclinically and clinically to have efficacy comparable to that of NSAIDs for relief of pain and inflammation in osteoarthritis, with decreased risk of gastrointestinal damage.	Celecoxib	61-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
12902855-6	2003	Two specific COX-2 inhibitors, namely, rofecoxib (Vioxx) and celecoxib (Celebrex), both oral agents and FDA approved, have been shown preclinically and clinically to have efficacy comparable to that of NSAIDs for relief of pain and inflammation in osteoarthritis, with decreased risk of gastrointestinal damage.	Celecoxib	72-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
12902857-3	2003	The discovery of the inducible cyclooxygenase enzyme (COX-2) and development of some highly selective inhibitors (which spare the constitutive COX-1 activity) has renewed excitement for modulating tumor prostaglandins as a method of specific radiosensitization of tumors, while sparing normal tissues.	Prostaglandins	203-217	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-59
12902866-1	2003	The selective cyclooxygenase (COX)-2 inhibitor, celecoxib, alone and in combination with radiation was investigated in vitro and in vivo.	Celecoxib	48-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-36
12902866-3	2003	Treatment of both tumor cells with celecoxib alone resulted in a dose- and time-dependent reduction of cell number (clonogenic cell death) and tumor cell growth rate in vitro; however, inhibition of tumor cell growth by celecoxib was not correlated with the reduction of COX-2 protein in tumor cells.	Celecoxib	35-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	271-276
12902866-12	2003	Our results indicate that the selective inhibition of COX-2 combined with radiation has potential application in radiotherapy, and celecoxib-mediated antitumor effects may act through different mechanisms including direct inhibition of tumor cell proliferation, alteration of tumor cell cycle, and antiangiogenesis.	Celecoxib	131-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-59
12890715-1	2003	(1) Unlike other nonsteroidal anti-inflammatory drugs that inhibit formation of cyclooxygenase (COX)-dependent eicosanoids, acetylation of COX-2 by aspirin switches eicosanoid biosynthesis from prostaglandin E(2) (PGE(2)) to 15-epi-lipoxin A(4) (15-epi-LXA(4) or aspirin-triggered lipoxin, ATL).	Prostaglandins E	194-209	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-144
12890715-1	2003	(1) Unlike other nonsteroidal anti-inflammatory drugs that inhibit formation of cyclooxygenase (COX)-dependent eicosanoids, acetylation of COX-2 by aspirin switches eicosanoid biosynthesis from prostaglandin E(2) (PGE(2)) to 15-epi-lipoxin A(4) (15-epi-LXA(4) or aspirin-triggered lipoxin, ATL).	Prostaglandins E	214-217	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-144
12890715-1	2003	(1) Unlike other nonsteroidal anti-inflammatory drugs that inhibit formation of cyclooxygenase (COX)-dependent eicosanoids, acetylation of COX-2 by aspirin switches eicosanoid biosynthesis from prostaglandin E(2) (PGE(2)) to 15-epi-lipoxin A(4) (15-epi-LXA(4) or aspirin-triggered lipoxin, ATL).	15-epi-lipoxin a	225-241	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-144
12890715-1	2003	(1) Unlike other nonsteroidal anti-inflammatory drugs that inhibit formation of cyclooxygenase (COX)-dependent eicosanoids, acetylation of COX-2 by aspirin switches eicosanoid biosynthesis from prostaglandin E(2) (PGE(2)) to 15-epi-lipoxin A(4) (15-epi-LXA(4) or aspirin-triggered lipoxin, ATL).	15-epi-lxa	246-256	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-144
12890715-1	2003	(1) Unlike other nonsteroidal anti-inflammatory drugs that inhibit formation of cyclooxygenase (COX)-dependent eicosanoids, acetylation of COX-2 by aspirin switches eicosanoid biosynthesis from prostaglandin E(2) (PGE(2)) to 15-epi-lipoxin A(4) (15-epi-LXA(4) or aspirin-triggered lipoxin, ATL).	Aspirin	263-270	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-144
12890715-1	2003	(1) Unlike other nonsteroidal anti-inflammatory drugs that inhibit formation of cyclooxygenase (COX)-dependent eicosanoids, acetylation of COX-2 by aspirin switches eicosanoid biosynthesis from prostaglandin E(2) (PGE(2)) to 15-epi-lipoxin A(4) (15-epi-LXA(4) or aspirin-triggered lipoxin, ATL).	Lipoxins	232-239	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-144
12890715-3	2003	(2) In the present study, we have examined the role of acetylated COX-2 and 5-LOX in modulating antiadhesive effects of aspirin on adhesion of PMN to endotoxin (LPS)-primed human umbilical endothelial cells (HUVEC).	Aspirin	120-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-77
12890715-5	2003	Treating HUVEC with selective COX-2 inhibitors, celecoxib and rofecoxib, caused an approximately 70% reversion of antiadhesive effect of aspirin.	Celecoxib	48-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-35
12890715-5	2003	Treating HUVEC with selective COX-2 inhibitors, celecoxib and rofecoxib, caused an approximately 70% reversion of antiadhesive effect of aspirin.	rofecoxib	62-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-35
12890715-5	2003	Treating HUVEC with selective COX-2 inhibitors, celecoxib and rofecoxib, caused an approximately 70% reversion of antiadhesive effect of aspirin.	Aspirin	137-144	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-35
14567460-0	2003	Molecular mechanisms involved in the antiproliferative effect of two COX-2 inhibitors, nimesulide and NS-398, on colorectal cancer cell lines.	nimesulide	87-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-74
14567460-0	2003	Molecular mechanisms involved in the antiproliferative effect of two COX-2 inhibitors, nimesulide and NS-398, on colorectal cancer cell lines.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	102-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-74
14567460-4	2003	AIMS: The aim of our study was to characterize the effects of two COX-2 selective inhibitors, NS-398 and nimesulide, on colorectal cancer cell proliferation, and to describe the molecular mechanisms involved.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	94-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-71
14567460-4	2003	AIMS: The aim of our study was to characterize the effects of two COX-2 selective inhibitors, NS-398 and nimesulide, on colorectal cancer cell proliferation, and to describe the molecular mechanisms involved.	nimesulide	105-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-71
12824303-1	2003	The cyclooxygenase (COX)-2 inhibitor Celecoxib may inhibit cancer cell growth independently of its capacity to block the COX-2 enzyme.	Celecoxib	37-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-26
12824303-1	2003	The cyclooxygenase (COX)-2 inhibitor Celecoxib may inhibit cancer cell growth independently of its capacity to block the COX-2 enzyme.	Celecoxib	37-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-126
12885537-1	2003	The ion-exchange rates and capacities of the zeolite NaY for the Cu(II), Co(II), and Pb(II) metal ions were investigated.	Zeolites	45-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-78
12838502-6	2003	However, treatment using ATP plus PPADS or with ADP-beta-S led to marked expression of COX-2.	Adenosine Triphosphate	25-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-92
12838502-6	2003	However, treatment using ATP plus PPADS or with ADP-beta-S led to marked expression of COX-2.	Adenosine 5'-[beta-thio]diphosphate trilithium salt	48-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-92
12838502-7	2003	The enhanced COX-2 with ATP plus PPADS treatment was absent in the presence of SKF96365 or using Ca(2+)-free solution.	Adenosine Triphosphate	24-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
12838502-7	2003	The enhanced COX-2 with ATP plus PPADS treatment was absent in the presence of SKF96365 or using Ca(2+)-free solution.	1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole	79-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
14609204-5	2003	Our findings implicate PAF requirement in orderly progression of the events involved in oral tissue repair, and suggest that the interference with its actions during healing process results in the suppression of COX-2-derived anti-inflammatory prostaglandins that delay the mucosal repair.	Prostaglandins	244-258	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	212-217
12885537-3	2003	The maximum ion exchange of metal ions into the zeolite was found to be 120 mg Pb(II), 110 mg Cu(II), and 100 mg Co(II) per gram of zeolite NaY.	Metals	28-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-119
12885537-3	2003	The maximum ion exchange of metal ions into the zeolite was found to be 120 mg Pb(II), 110 mg Cu(II), and 100 mg Co(II) per gram of zeolite NaY.	Zeolites	48-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-119
12885537-3	2003	The maximum ion exchange of metal ions into the zeolite was found to be 120 mg Pb(II), 110 mg Cu(II), and 100 mg Co(II) per gram of zeolite NaY.	Zeolites	132-139	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-119
12885537-4	2003	It is observed that the exchange capacity of a zeolite varies with the exchanged metal ion and the amount of metal ions exchanged into zeolite decreases in the sequence Pb(II) &gt; Cu(II) &gt; Co(II).	Zeolites	47-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	193-199
12885537-4	2003	It is observed that the exchange capacity of a zeolite varies with the exchanged metal ion and the amount of metal ions exchanged into zeolite decreases in the sequence Pb(II) &gt; Cu(II) &gt; Co(II).	Metals	81-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	193-199
12885537-4	2003	It is observed that the exchange capacity of a zeolite varies with the exchanged metal ion and the amount of metal ions exchanged into zeolite decreases in the sequence Pb(II) &gt; Cu(II) &gt; Co(II).	Metals	109-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	193-199
12885537-4	2003	It is observed that the exchange capacity of a zeolite varies with the exchanged metal ion and the amount of metal ions exchanged into zeolite decreases in the sequence Pb(II) &gt; Cu(II) &gt; Co(II).	Zeolites	135-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	193-199
12885537-4	2003	It is observed that the exchange capacity of a zeolite varies with the exchanged metal ion and the amount of metal ions exchanged into zeolite decreases in the sequence Pb(II) &gt; Cu(II) &gt; Co(II).	pb(ii)	169-175	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	193-199
12885537-4	2003	It is observed that the exchange capacity of a zeolite varies with the exchanged metal ion and the amount of metal ions exchanged into zeolite decreases in the sequence Pb(II) &gt; Cu(II) &gt; Co(II).	cu(ii)	181-187	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	193-199
12868935-0	2003	Addition of carboxyalkyl radicals to alkenes through a catalytic process, using a Mn(II)/Co(II)/O2 redox system.	carboxyalkyl radicals	12-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-95
12859668-3	2003	The late increase in PGE2 levels (24 h) was more potently reduced by the highly selective COX-2 inhibitor rofecoxib (20 mg/kg) relative to the COX-1 inhibitor valeryl salicylate (20 mg/kg).	Dinoprostone	21-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-95
12859668-3	2003	The late increase in PGE2 levels (24 h) was more potently reduced by the highly selective COX-2 inhibitor rofecoxib (20 mg/kg) relative to the COX-1 inhibitor valeryl salicylate (20 mg/kg).	rofecoxib	106-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-95
12859668-5	2003	Post-ischemia treatment with rofecoxib (starting 6 h after restoration of blood flow) significantly reduced measures of oxidative damage (glutathione depletion and lipid peroxidation) seen at 48 h after the initial ischemic episode, indicating that the late increase in COX-2 activity is involved in the delayed occurrence of oxidative damage in the hippocampus after global ischemia.	rofecoxib	29-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	270-275
12859668-6	2003	Interestingly, either selective inhibition of COX-2 with rofecoxib or inhibition of COX-1 with valeryl salicylate significantly increased the number of healthy neurons in the hippocampal CA1 sector even when the treatment began 6 h after ischemia.	rofecoxib	57-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
12769697-6	2003	Surprisingly aspirin, which is selective for COX-1 over COX-2, and sulindac, which is an equipotent inhibitor of the COX isoenzymes, appear to have a similar anticancer profile to the COX-2 selective NSAIDs.	Sulindac	67-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	184-189
12769697-8	2003	The first of these relates to the unique mode of action of aspirin, which acetylates the COX-2 enzyme and generates the cancer-suppressing 15R-hydroxyeicosatetraenoic acid at the site of a potential tumour.	Aspirin	59-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-94
12769697-8	2003	The first of these relates to the unique mode of action of aspirin, which acetylates the COX-2 enzyme and generates the cancer-suppressing 15R-hydroxyeicosatetraenoic acid at the site of a potential tumour.	SCHEMBL1095636	139-171	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-94
12837940-1	2003	Cyclooxygenase (COX)-2, a rate-limiting enzyme of prostaglandin (PG) production, is overexpressed in colorectal adenomas and adenocarcinomas, and its inhibition by nonsteroidal antiinflammatory drugs protects against colorectal cancer.	Prostaglandins	50-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-22
12837940-8	2003	Furthermore, inhibition of COX-2 in cells overexpressing the enzyme decreases c-IAP2 expression and promotes apoptosis, both of which are reversible by PGE2 addition, suggesting that COX-2-promoted antiapoptosis is mediated by release of PGE2 and subsequent cAMP-dependent c-IAP2 induction.	Dinoprostone	152-156	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-32
12837940-8	2003	Furthermore, inhibition of COX-2 in cells overexpressing the enzyme decreases c-IAP2 expression and promotes apoptosis, both of which are reversible by PGE2 addition, suggesting that COX-2-promoted antiapoptosis is mediated by release of PGE2 and subsequent cAMP-dependent c-IAP2 induction.	Dinoprostone	152-156	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	183-188
12837940-8	2003	Furthermore, inhibition of COX-2 in cells overexpressing the enzyme decreases c-IAP2 expression and promotes apoptosis, both of which are reversible by PGE2 addition, suggesting that COX-2-promoted antiapoptosis is mediated by release of PGE2 and subsequent cAMP-dependent c-IAP2 induction.	Dinoprostone	238-242	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-32
12837940-8	2003	Furthermore, inhibition of COX-2 in cells overexpressing the enzyme decreases c-IAP2 expression and promotes apoptosis, both of which are reversible by PGE2 addition, suggesting that COX-2-promoted antiapoptosis is mediated by release of PGE2 and subsequent cAMP-dependent c-IAP2 induction.	Dinoprostone	238-242	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	183-188
15071803-0	2003	High performance liquid chromatographic determination of cox-2 inhibitor rofecoxib in human plasma.	rofecoxib	73-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-62
12837940-8	2003	Furthermore, inhibition of COX-2 in cells overexpressing the enzyme decreases c-IAP2 expression and promotes apoptosis, both of which are reversible by PGE2 addition, suggesting that COX-2-promoted antiapoptosis is mediated by release of PGE2 and subsequent cAMP-dependent c-IAP2 induction.	Cyclic AMP	258-262	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-32
12868935-0	2003	Addition of carboxyalkyl radicals to alkenes through a catalytic process, using a Mn(II)/Co(II)/O2 redox system.	Alkenes	37-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-95
12837940-8	2003	Furthermore, inhibition of COX-2 in cells overexpressing the enzyme decreases c-IAP2 expression and promotes apoptosis, both of which are reversible by PGE2 addition, suggesting that COX-2-promoted antiapoptosis is mediated by release of PGE2 and subsequent cAMP-dependent c-IAP2 induction.	Cyclic AMP	258-262	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	183-188
12868935-0	2003	Addition of carboxyalkyl radicals to alkenes through a catalytic process, using a Mn(II)/Co(II)/O2 redox system.	Manganese(2+)	82-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-95
12868935-0	2003	Addition of carboxyalkyl radicals to alkenes through a catalytic process, using a Mn(II)/Co(II)/O2 redox system.	Oxygen	96-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-95
12868935-1	2003	A novel strategy for production of mono- and dicarboxylic acids by the addition of carboxyalkyl radicals to alkenes and dienes, respectively, was successfully developed through a catalytic process with use of Mn(II)/Co(II)/O(2) system.	mono- and dicarboxylic acids	35-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	216-222
12868935-1	2003	A novel strategy for production of mono- and dicarboxylic acids by the addition of carboxyalkyl radicals to alkenes and dienes, respectively, was successfully developed through a catalytic process with use of Mn(II)/Co(II)/O(2) system.	carboxyalkyl radicals	83-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	216-222
12868935-1	2003	A novel strategy for production of mono- and dicarboxylic acids by the addition of carboxyalkyl radicals to alkenes and dienes, respectively, was successfully developed through a catalytic process with use of Mn(II)/Co(II)/O(2) system.	Alkenes	108-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	216-222
12868935-1	2003	A novel strategy for production of mono- and dicarboxylic acids by the addition of carboxyalkyl radicals to alkenes and dienes, respectively, was successfully developed through a catalytic process with use of Mn(II)/Co(II)/O(2) system.	dienes	120-126	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	216-222
12880869-5	2003	However, this enzyme failed to produce PGF(2alpha) from endogenous AA, even though significant increase in PGF(2alpha) production occurred in cells transfected with COX-2 alone.	Prostaglandins F	107-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	165-170
12868935-1	2003	A novel strategy for production of mono- and dicarboxylic acids by the addition of carboxyalkyl radicals to alkenes and dienes, respectively, was successfully developed through a catalytic process with use of Mn(II)/Co(II)/O(2) system.	Manganese(2+)	209-215	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	216-222
12956057-2	2003	2:1:2:1 mixture of the stilbenolignan (+/-)-aiphanol (1) and congeners 2-4 each of which show significant anti-angiogenic and COX-2 inhibitory properties.	aiphanol	38-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-131
12868935-1	2003	A novel strategy for production of mono- and dicarboxylic acids by the addition of carboxyalkyl radicals to alkenes and dienes, respectively, was successfully developed through a catalytic process with use of Mn(II)/Co(II)/O(2) system.	Oxygen	223-227	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	216-222
12925150-8	2003	DEX inhibited HGF mRNA and COX-2 mRNA.	Dexamethasone	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-32
12821125-0	2003	PGE(2) is generated by specific COX-2 activity and increases VEGF production in COX-2-expressing human pancreatic cancer cells.	Dinoprostone	0-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-37
12821125-0	2003	PGE(2) is generated by specific COX-2 activity and increases VEGF production in COX-2-expressing human pancreatic cancer cells.	Dinoprostone	0-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-85
12821125-3	2003	COX-2 expression correlated with basal and arachidonic acid (AA) stimulated PGE(2) production.	Arachidonic Acid	43-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
12821125-3	2003	COX-2 expression correlated with basal and arachidonic acid (AA) stimulated PGE(2) production.	Dinoprostone	76-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
12821125-4	2003	PGE(2) production was inhibited by the COX-2 inhibitor nimesulide.	Dinoprostone	0-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-44
12821125-4	2003	PGE(2) production was inhibited by the COX-2 inhibitor nimesulide.	nimesulide	55-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-44
12821125-5	2003	In COX-2 expressing cells, exogenous AA and PGE(2) increased VEGF synthesis via the EP(2) receptor.	Prostaglandins E	44-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	3-8
12821125-6	2003	Whereas PGE(2) stimulated intracellular cAMP formation in COX-2 positive and negative cells, 8-bromo cAMP stimulated VEGF production only in COX-2 expressing cells.	Dinoprostone	8-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
12821125-6	2003	Whereas PGE(2) stimulated intracellular cAMP formation in COX-2 positive and negative cells, 8-bromo cAMP stimulated VEGF production only in COX-2 expressing cells.	Cyclic AMP	40-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
12821125-6	2003	Whereas PGE(2) stimulated intracellular cAMP formation in COX-2 positive and negative cells, 8-bromo cAMP stimulated VEGF production only in COX-2 expressing cells.	8-Bromo Cyclic Adenosine Monophosphate	93-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	141-146
12821125-9	2003	PGE(2) generated by specific COX-2 activity increases VEGF secretion in human PaCa cells through an autocrine mechanism.	Prostaglandins E	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34
12798335-1	2003	A novel class of 3-(4-methanesulfonylphenyl)-4-phenylpyran-2-ones possessing a central six-membered lactone (pyran-2-one) ring system, in conjunction with C-6 alkyl (Me, Et or i-Pr), alkoxy (OMe, OEt or O-i-Pr), and alkylthio (SMe, SEt or S-i-Pr) substituents, were designed for evaluation as selective COX-2 inhibitors.	3-(4-methanesulfonylphenyl)-4-phenylpyran-2-ones	17-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	303-308
12798335-1	2003	A novel class of 3-(4-methanesulfonylphenyl)-4-phenylpyran-2-ones possessing a central six-membered lactone (pyran-2-one) ring system, in conjunction with C-6 alkyl (Me, Et or i-Pr), alkoxy (OMe, OEt or O-i-Pr), and alkylthio (SMe, SEt or S-i-Pr) substituents, were designed for evaluation as selective COX-2 inhibitors.	Pyrones	53-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	303-308
12842195-8	2003	Interestingly, the COX-2 protein and COX-2 mRNA were not detected in U937 cells, and their levels remained undetectable during the entire course of RA treatment.	Tretinoin	148-150	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-24
12974196-3	2003	In this study, we evaluated the safety and convenience of a single full-dose challenge with nabumetone, a selective COX-2 inhibitor, in patients with hypersensitivity to nonselective NSAIDs (ns-NSAIDs).	Nabumetone	92-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-121
12845388-1	2003	Rofecoxib (VIOXX, Merck &amp; Co., West Point, PA) is a COX-2-selective inhibitor that combines anti-inflammatory and analgesic efficacy with improved gastrointestinal (GI) safety.	rofecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-61
12759799-0	2003	Speciation of Co(II), Co(III), and Cu(II) in ethylenediamine solutions by capillary electrophoresis.	ethylenediamine	45-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-20
12845388-1	2003	Rofecoxib (VIOXX, Merck &amp; Co., West Point, PA) is a COX-2-selective inhibitor that combines anti-inflammatory and analgesic efficacy with improved gastrointestinal (GI) safety.	rofecoxib	11-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-61
12845388-1	2003	Rofecoxib (VIOXX, Merck &amp; Co., West Point, PA) is a COX-2-selective inhibitor that combines anti-inflammatory and analgesic efficacy with improved gastrointestinal (GI) safety.	merck	18-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-61
12672669-1	2003	Labor is preceded by cervical ripening through upregulation of interleukin (IL)-1beta, IL-8, and increased prostaglandin synthesis via inducible type 2 cyclooxygenase (COX-2).	Prostaglandins	107-120	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	168-173
12807725-0	2003	Curcumin (diferuloylmethane) down-regulates cigarette smoke-induced NF-kappaB activation through inhibition of IkappaBalpha kinase in human lung epithelial cells: correlation with suppression of COX-2, MMP-9 and cyclin D1.	Curcumin	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	195-200
12818939-1	2003	UNLABELLED: The goal of our study was to evaluate the analgesic efficacy and safety of administering rofecoxib (1 mg/kg), a cyclo-oxygenase (COX)-2 selective nonsteroidal antiinflammatory drug, before pediatric tonsillectomy.	rofecoxib	101-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	124-147
12807725-0	2003	Curcumin (diferuloylmethane) down-regulates cigarette smoke-induced NF-kappaB activation through inhibition of IkappaBalpha kinase in human lung epithelial cells: correlation with suppression of COX-2, MMP-9 and cyclin D1.	Curcumin	10-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	195-200
14508092-3	2003	The clinical use of these agents is limited to patients with familial adenomatous polyposis (FAP), which may benefit from chemopreventive treatment with sulindac or the selective COX-2 inhibitor celecoxib.	Celecoxib	195-204	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	179-184
15017670-11	2003	CONCLUSIONS: In hepatolithiasis, an enhanced synthesis of sPLA(2)-/COX-2-derived PGE(2) and its actions mediated via the EP(4) receptor in the bile ducts may be of pathobiological significance for chronic proliferative cholangitis.	Prostaglandins E	81-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-72
12818440-1	2003	OBJECTIVE: To investigate the effects of inhibitors of COX-1 or COX-2 on myometrial prostaglandin synthesis and on spontaneous contractions in human myometrium.	Prostaglandins	84-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-69
12759338-3	2003	Here, we show that both R- and S-flurbiprofen reduce survival of three colon cancer cell lines, which differ in the expression of COX-2 (HCT-15, no COX-2; Caco-2, inducible COX-2; and HT-29, constitutive COX-2).	r- and s-flurbiprofen	24-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	130-135
12792783-0	2003	Specific COX-2 inhibitor, NS-398, suppresses cellular proliferation and induces apoptosis in human hepatocellular carcinoma cells.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	26-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	9-14
12792783-3	2003	This study investigated the effects of a specific COX-2 inhibitor, NS-398, on the cell proliferation and apoptosis of COX-2-expressing and non-expressing HCC cell lines.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	67-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-55
12792783-3	2003	This study investigated the effects of a specific COX-2 inhibitor, NS-398, on the cell proliferation and apoptosis of COX-2-expressing and non-expressing HCC cell lines.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	67-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-123
12792783-6	2003	NS-398 suppressed cell proliferation and induced apoptosis in the two COX-2-expressing cell lines in a dose-dependent manner, but not in HepG2 cells.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	0-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-75
12811211-0	2003	Celecoxib associated esophagitis: review of gastrointestinal side effects from cox-2 inhibitors.	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-84
12811211-10	2003	SUMMARY: We report for the first time severe esophagitis caused by the COX-2 inhibitor Celecoxib.	Celecoxib	87-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-76
14748383-0	2003	Efficacy and safety of the first parenteral selective COX-2 inhibitor, parecoxib sodium, in adult patients with postoperative pain.	parecoxib	71-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-59
14748383-1	2003	Parecoxib, a prodrug of valdecoxib, a selective COX-2 inhibitor, has been recently introduced for the treatment of moderate to severe postoperative pain.	parecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-53
14748383-1	2003	Parecoxib, a prodrug of valdecoxib, a selective COX-2 inhibitor, has been recently introduced for the treatment of moderate to severe postoperative pain.	valdecoxib	24-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-53
12906745-8	2003	Emerging evidence suggests that rofecoxib may also find potential use as supportive therapy in various pathophysiologic conditions like Alzheimer"s disease, and in various malignant tumours and polyps, where COX-2 is overly expressed.	rofecoxib	32-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	208-213
12910692-7	2003	Immunohistochemistry and immunoblotting indicated that aspirin effectively decreased COX-2 and c-fos expression in SGC-7901 cell.	Aspirin	55-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-90
12910692-10	2003	The anti-neoplastic effect aspirin produces may involve the inhibition of COX-2 expression and AP-1 activity.	Aspirin	27-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
12910695-12	2003	Rofecoxib down-regulated the expression of COX-2 and PCNA of SGC7901 cell, both in vitro and in vivo.	rofecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
12816478-3	2003	The first reported examples of the catalytic asymmetric ring-opening of meso-epoxy-1,2-dioxines using a range of chiral Co(II) salen and beta-ketoiminato complexes to afford highly enantio-enriched 4-hydroxy-2,3-epoxy-ketones are also presented.	meso-epoxy-1,2-dioxines	72-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-125
12816478-3	2003	The first reported examples of the catalytic asymmetric ring-opening of meso-epoxy-1,2-dioxines using a range of chiral Co(II) salen and beta-ketoiminato complexes to afford highly enantio-enriched 4-hydroxy-2,3-epoxy-ketones are also presented.	4-hydroxy-2,3-epoxy-ketones	198-225	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-125
12904261-6	2003	COX-2 inhibition may decrease endothelial inflammation reducing monocytes infiltration improving vascular cells function, plaque stability and probably resulting in a decrease of coronary atherothrombotic events.Trials including large numbers of patients in prospective double-blind randomized studies worthwhile to confirm the efficacy of NSAID, mainly, COX-2 inhibitors, together with aspirin in the prevention of coronary events in patients with acute coronary disease.	Aspirin	387-394	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
12823157-5	2003	AIM: To study the impact of COX-2 specific inhibition on gastric prostaglandin levels, H. pylori gastritis and proliferation.	Prostaglandins	65-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
14592547-0	2003	Control of COX-2 and iNOS gene expressions by aspirin and salicylate.	Aspirin	46-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-16
14592547-0	2003	Control of COX-2 and iNOS gene expressions by aspirin and salicylate.	Salicylates	58-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-16
14592549-2	2003	An incomplete suppression of platelet thromboxane (TX) A2 biosynthesis has been assumed to participate in the phenomenon of aspirin resistance, as a consequence of the following possible mechanisms: (i) COX-2 expression in newly formed platelets; (ii) pharmacodynamic interactions between aspirin and coadministered nonsteroidal antiinflammatory drugs (e.g. ibuprofen); (iii) expression of variant isoforms of COX-1 with reduced sensitivity to irreversible inactivation at Ser529.	Aspirin	124-131	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	203-208
14592549-4	2003	Thus, in a subset of patients with unstable angina treated with low-dose aspirin, to almost completely block platelet COX-1 activity, enhanced TXA2 biosynthesis in vivo has been demonstrated, presumably through an increased generation of COX-2-dependent PGH2 in plaque monocytes/macrophages or activated vascular cells.	Aspirin	73-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	238-243
14592549-4	2003	Thus, in a subset of patients with unstable angina treated with low-dose aspirin, to almost completely block platelet COX-1 activity, enhanced TXA2 biosynthesis in vivo has been demonstrated, presumably through an increased generation of COX-2-dependent PGH2 in plaque monocytes/macrophages or activated vascular cells.	Prostaglandin H2	254-258	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	238-243
14592550-8	2003	On the other hand, the selective inhibitor of COX-2 (rofecoxib) as well as the inhibitor of cytochrome P450-dependent monoxygenase (17-ODYA) were ineffective.	rofecoxib	53-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
14592551-6	2003	Use of the selective COX-2 inhibitor, NS-398, indicated that COX activity in hypoxic corneas or cells is essentially that of COX-2; in control cells, both COX-1 and COX-2 contributed equally to the production of PGE2.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	38-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-26
14592551-6	2003	Use of the selective COX-2 inhibitor, NS-398, indicated that COX activity in hypoxic corneas or cells is essentially that of COX-2; in control cells, both COX-1 and COX-2 contributed equally to the production of PGE2.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	38-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-130
14592551-6	2003	Use of the selective COX-2 inhibitor, NS-398, indicated that COX activity in hypoxic corneas or cells is essentially that of COX-2; in control cells, both COX-1 and COX-2 contributed equally to the production of PGE2.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	38-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-130
14592551-7	2003	COX-2 protein overexpression induced by hypoxia was not associated with a parallel increase in PGE2 accumulation but the enzyme regained full catalytic activity when cells were re-exposed to normoxia in the presence of heme and arachidonic acid.	Heme	219-223	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
14592551-7	2003	COX-2 protein overexpression induced by hypoxia was not associated with a parallel increase in PGE2 accumulation but the enzyme regained full catalytic activity when cells were re-exposed to normoxia in the presence of heme and arachidonic acid.	Arachidonic Acid	228-244	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
14592552-0	2003	Effects of phenacetin and its metabolite p-phenetidine on COX-1 and COX-2 activities and expression in vitro.	Phenacetin	11-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-73
14592552-0	2003	Effects of phenacetin and its metabolite p-phenetidine on COX-1 and COX-2 activities and expression in vitro.	Phenetidine	41-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-73
14592552-1	2003	The present study was aimed to test the possible cyclooxygenase (COX)-1/COX-2 selectivity of the old analgesic drug phenacetin and its metabolite p-phenetidine, which exhibits high renal toxicity.	Phenacetin	116-126	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
14592552-1	2003	The present study was aimed to test the possible cyclooxygenase (COX)-1/COX-2 selectivity of the old analgesic drug phenacetin and its metabolite p-phenetidine, which exhibits high renal toxicity.	Phenetidine	146-159	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
14592552-3	2003	Collagen-stimulated platelet thromboxane B2 (TxB2) production and phorbol 12-myristate-13-acetate (PMA)-induced neutrophil prostaglandin E2 (PGE2) synthesis were used as indicators for COX-1 and COX-2 activity, respectively.	Tetradecanoylphorbol Acetate	99-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	195-200
14592552-6	2003	Somewhat higher, micromolar, concentrations of p-phenetidine also reduced COX-2 expression in neutrophils.	Phenetidine	47-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
14592552-7	2003	We suggest that the very potent inhibitory activity of p-phenetidine on PGE2 synthesis combined with the reduction of COX-2 expression could explain the renal papillary necrosis in phenacetin kidney.	Phenacetin	181-191	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-123
18969048-3	2003	Light emission was produced for the chemiluminescence reaction between luminol and hydrogen peroxide in buffer carbonate conditions (pH 10.8) catalysed by Cr(III), Co(II) and Cu(II).	Luminol	71-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	164-170
18969048-3	2003	Light emission was produced for the chemiluminescence reaction between luminol and hydrogen peroxide in buffer carbonate conditions (pH 10.8) catalysed by Cr(III), Co(II) and Cu(II).	Hydrogen Peroxide	83-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	164-170
18969048-3	2003	Light emission was produced for the chemiluminescence reaction between luminol and hydrogen peroxide in buffer carbonate conditions (pH 10.8) catalysed by Cr(III), Co(II) and Cu(II).	Carbonates	111-120	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	164-170
12763047-2	2003	We determined which COX-isoform, COX-1 or COX-2, determines loading-induced prostaglandin production in primary bone cells in vitro.	Prostaglandins	76-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47
12763047-4	2003	Inhibition of COX-2 activity with NS-398 abolished the stimulating effect of PFF both at 1 h and at 24 h post-incubation, while inhibition of COX-1 by SC-560 affected neither the early nor the late response to flow.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	34-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
12763047-5	2003	PFF rapidly stimulated COX-2 mRNA expression at 1 h but did not affect COX-1 mRNA expression.	p-Fluorophenylalanine	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-28
12794895-4	2003	Furthermore, 4 also signalled the presence of Fe(II), Co(II), Ni(II) and Ag(I) ions by the precipitation of coordination polymers, and exhibited reversible proton-triggered fluorescence quenching behaviour.	Polymers	121-129	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-60
12767201-6	2003	Apparent heterogeneous electron-transfer rate constants derived from sweep-rate dependent cyclic voltammetric peak potential separations in 1,2-dichloroethane are small and decrease as pzTp &gt; Tp &gt; Tp for the Co(III)/Co(II) couples.	ethylene dichloride	140-158	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	222-228
12783912-2	2003	OBJECTIVE: To determine whether treatment with a selective cyclooxygenase (COX) -2 inhibitor (rofecoxib) or a traditional nonselective NSAID (naproxen) slows cognitive decline in patients with mild-to-moderate AD.	rofecoxib	94-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-82
12948125-7	2003	In comparison with THB, amineboranes and NaBH3CN allowed, in general, a better control of interference effects of Fe(III), Ni(II), Co(II), and Cu(II).	amineboranes	24-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-136
12948125-7	2003	In comparison with THB, amineboranes and NaBH3CN allowed, in general, a better control of interference effects of Fe(III), Ni(II), Co(II), and Cu(II).	sodium cyanoborohydride	41-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-136
12794822-7	2003	Upon stimulation with IL-1beta, elevation of COX-2, but not COX-1, mRNA and protein preceded the enhancement of PGE(2) synthesis.	Dinoprostone	112-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-50
12794822-8	2003	In the presence of 300-400 microM Tau-Cl, significant inhibition of IL-1beta-triggered COX-2 mRNA and protein, and a related decrease in PGE(2) production, was observed.	N-chlorotaurine	34-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-92
12794822-10	2003	CONCLUSION: Tau-Cl inhibits IL-1beta-triggered elevation of COX-2 and generation of PGE(2) by RA FLS.	N-chlorotaurine	12-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-65
12814375-7	2003	COX2 is inhibited by glucorticoids; there was no difference in blood corticosterone levels as measured by radioimmunoassay in any condition.	glucorticoids	21-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-4
12782016-3	2003	We demonstrate that rofecoxib, a selective COX-2 inhibitor, acts directly on human dermal microvascular ECs (HMVECs) to inhibit their chemotactic and tube forming ability.	rofecoxib	20-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
12803569-6	2003	The COX-2 selective agents, the coxibs, which inhibit prostanoid biosynthesis at inflammatory sites, but not the endogenous protective prostanoids in the gut formed by COX-1, have proved so far to be a successful therapeutic approach to reducing NSAIDs GI damage.	Prostaglandins	54-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
12740337-1	2003	BACKGROUND: Previous studies in patients with osteoarthritis have suggested that the selective cyclooxygenase (COX)-2 inhibitor rofecoxib results in less gastrointestinal damage than non-selective non-steroidal antiinflammatory drugs (NSAIDs).	rofecoxib	128-137	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-117
12817520-0	2003	Characterization of etoricoxib, a novel, selective COX-2 inhibitor.	Etoricoxib	20-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-56
12817520-1	2003	Etoricoxib is a potent selective COX-2 inhibitor in man.	Etoricoxib	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-38
12817520-12	2003	Based on these results, etoricoxib is a potent selective inhibitor of COX-2 after single and multiple dosing regimens and does not inhibit prostaglandin synthesis in the gastric mucosa, even at doses above the clinical dose range of 60 to 120 mg.	Etoricoxib	24-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-75
12755960-4	2003	Animal and human data, however, suggest that COX-2 synthesized prostaglandins are important in the modulation of renal physiology during adverse conditions.	Prostaglandins	63-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-50
12773508-5	2003	NS-398, a cyclooxygenase (COX)-2-selective inhibitor, suppressed LPS-enhanced EP(2)R/EP(4)R expression, suggesting that COX-2-issued prostaglandin E(2) (PGE(2)) modulates DC function through stimulation of specific EPR subtypes.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	0-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-125
12773508-5	2003	NS-398, a cyclooxygenase (COX)-2-selective inhibitor, suppressed LPS-enhanced EP(2)R/EP(4)R expression, suggesting that COX-2-issued prostaglandin E(2) (PGE(2)) modulates DC function through stimulation of specific EPR subtypes.	Dinoprostone	133-151	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-125
12773508-5	2003	NS-398, a cyclooxygenase (COX)-2-selective inhibitor, suppressed LPS-enhanced EP(2)R/EP(4)R expression, suggesting that COX-2-issued prostaglandin E(2) (PGE(2)) modulates DC function through stimulation of specific EPR subtypes.	Prostaglandins E	153-156	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-125
12771797-2	2003	The discovery and elucidation of prostaglandin pathways, in particular the molecular and clinical role of cyclooxygenase (COX)-2 function, has had important application to neoplasms.	Prostaglandins	33-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-128
12813861-9	2003	Stimulated production of PGs by osteoblasts requires both the induction of COX-2 expression and the availability of arachidonic acid substrate.	Prostaglandins	25-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
12813861-12	2003	We report that COX-2 expression and associated PG production are necessary for maximal resorption responses to 1,25 (OH)2D3 and parathyroid hormone (PTH).	Calcitriol	111-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-20
12870263-2	2003	The biological effects induced by aspirin and indomethacin on T98G cells, in which the expression of cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) were confirmed by RT-PCR and immunostaining, were investigated by studying cell proliferation and apoptosis assays.	Aspirin	34-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	148-153
12870263-2	2003	The biological effects induced by aspirin and indomethacin on T98G cells, in which the expression of cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) were confirmed by RT-PCR and immunostaining, were investigated by studying cell proliferation and apoptosis assays.	Indomethacin	46-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	148-153
12711837-9	2003	Etodolac and meloxicam showed selectivity for human COX-2 over COX-1.	Etodolac	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-57
12711837-9	2003	Etodolac and meloxicam showed selectivity for human COX-2 over COX-1.	Meloxicam	13-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-57
12800245-18	2003	Celecoxib as a chemopreventive and chemotherapeutic agent might be effective primarily on COX-2-expressing cholangiocarcinoma.	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-95
12626523-1	2003	Microsomal prostaglandin E2 synthase-1 (mPGES-1) is a stimulus-inducible enzyme that functions downstream of cyclooxygenase (COX)-2 in the PGE2-biosynthetic pathway.	Dinoprostone	11-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-131
12626523-1	2003	Microsomal prostaglandin E2 synthase-1 (mPGES-1) is a stimulus-inducible enzyme that functions downstream of cyclooxygenase (COX)-2 in the PGE2-biosynthetic pathway.	Dinoprostone	139-143	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-131
12626523-2	2003	Given the accumulating evidence that COX-2-derived PGE2 participates in the development of various tumors, including colorectal cancer, we herein examined the potential involvement of mPGES-1 in tumorigenesis.	Dinoprostone	51-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-42
12785851-12	2003	This difference in coordination modes concurs with the suggestion that a possible reason for the lower activity of Co(II)-carbonic anhydrase is associated with enhanced bidentate coordination of bicarbonate inhibiting its displacement.	Bicarbonates	195-206	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-121
12729631-1	2003	A number of naphthofuranones were synthesized and tested for COX-1 and COX-2 inhibition.	naphthofuranones	12-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-76
12759799-1	2003	A capillary electrophoretic (CE) method for the speciation of Co(II), Co(III), and Cu(II) in electroless copper-plating baths containing ethylenediamine (En) has been developed.	ethylenediamine	137-152	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-68
12759799-2	2003	The method is based on the selective pre-capillary derivatization of Co(II) with 1,10-phenanthroline (Phen) followed by CE separation of stable [CoPhen(3)](2+), [CoEn(3)](3+), and [CuEn(2)](2+) chelates.	1,10-phenanthroline	81-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-75
12759799-2	2003	The method is based on the selective pre-capillary derivatization of Co(II) with 1,10-phenanthroline (Phen) followed by CE separation of stable [CoPhen(3)](2+), [CoEn(3)](3+), and [CuEn(2)](2+) chelates.	1,10-phenanthroline	102-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-75
12759799-3	2003	The proposed derivatization procedure protects Co(II) from oxidation by dissolved oxygen and enables rapid determination of all three metal species within a single run.	Oxygen	82-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-53
12759799-3	2003	The proposed derivatization procedure protects Co(II) from oxidation by dissolved oxygen and enables rapid determination of all three metal species within a single run.	Metals	134-139	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-53
12759799-7	2003	Application of the method to the speciation of Co(II), Co(III), and Cu(II) in copper-plating bath samples is also demonstrated.	Copper	78-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-53
14594546-3	2003	Recent data showed that COX-2 and the derived prostaglandins are involved in control of cellular growth, apoptosis, and signal through a group of nuclear receptors named peroxisome proliferator-activated receptors (PPARs).	Prostaglandins	46-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
12840061-7	2003	Also, 20-mM graduated reductions in [NaCl]L between 80 and 0 mM caused step-by-step increases in HEK/EP1 [Ca2+]i. Low-salt diet greatly increased the expression of both COX-2 and microsome-associated PGE synthase (mPGES) in the MD.	Sodium Chloride	37-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	169-174
12840061-7	2003	Also, 20-mM graduated reductions in [NaCl]L between 80 and 0 mM caused step-by-step increases in HEK/EP1 [Ca2+]i. Low-salt diet greatly increased the expression of both COX-2 and microsome-associated PGE synthase (mPGES) in the MD.	Salts	118-122	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	169-174
14505259-3	2003	Cyclooxygenase (COX)-2 is a rate-limiting enzyme in the biosynthesis of prostaglandins and is mainly expressed in inflammatory and malignant processes.	Prostaglandins	72-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-22
12771933-8	2003	Finally, ZOL reduces Cox-2 expression and, consequently, the secretion of prostaglandins E2 (PGE2) in a RhoA-independent manner.	Zoledronic Acid	9-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-26
12733932-2	2003	Cob(II)ester (heptamethyl cobyrinate perchlorate) is found to be soluble in both polar and nonpolar solvents and is therefore very suitable to study solvent effects on Co(II) corrinates.	heptamethyl cobyrinate perchlorate)	14-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	168-174
12505789-8	2003	Thrombin, therefore, upregulates COX-2-derived PGE(2) synthesis by both catalytic cleavage of PAR(1) and bFGF-dependent noncatalytic activity.	Dinoprostone	47-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-38
12740813-5	2003	We show that the cavity of corrin is close to ideal for low-spin Co(III), Co(II), and Co(I) with the axial ligands encountered in biology, whereas the cavity in porphine is better suited for intermediate-spin states.	corrin	27-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-80
12740813-9	2003	Finally, Fe(II/III) gives a much lower reorganisation energy than Co(II/III); this is owing to the occupied d(z2) orbital in Co(II).	Iron	9-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-131
12740813-9	2003	Finally, Fe(II/III) gives a much lower reorganisation energy than Co(II/III); this is owing to the occupied d(z2) orbital in Co(II).	co(ii	66-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-131
12772890-0	2003	Coordination polymers based on square planar Co(II) node and linear spacer: solvent-dependent pseudo-polymorphism and an unprecedented interpenetrating structure containing both 2D and 3D topological isomers.	Polymers	13-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-51
12772922-1	2003	In the chiral Co(III)(salen)-catalysed HKR of racemic epoxides, in the presence of ionic liquids, Co(II)(salen) complex is oxidised without acetic acid to catalytically active Co(III)(salen) complex during reaction and, moreover, this oxidation state is stabilised against reduction to Co(II) complex which enables the reuse of the recovered catalyst for consecutive reactions without extra reoxidation.	Epoxy Compounds	54-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-104
12772922-1	2003	In the chiral Co(III)(salen)-catalysed HKR of racemic epoxides, in the presence of ionic liquids, Co(II)(salen) complex is oxidised without acetic acid to catalytically active Co(III)(salen) complex during reaction and, moreover, this oxidation state is stabilised against reduction to Co(II) complex which enables the reuse of the recovered catalyst for consecutive reactions without extra reoxidation.	Epoxy Compounds	54-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	286-292
12816478-0	2003	Base- and Co(II)-catalyzed ring-opening reactions of perhydrooxireno[2,3-d][1,2]dioxines: an efficient route to 4-hydroxy-2,3-epoxy-ketones.	perhydrooxireno[2,3-d][1,2]dioxines	53-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
12816478-0	2003	Base- and Co(II)-catalyzed ring-opening reactions of perhydrooxireno[2,3-d][1,2]dioxines: an efficient route to 4-hydroxy-2,3-epoxy-ketones.	4-hydroxy-2,3-epoxy-ketones	112-139	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
12816478-2	2003	Unsymmetrical epoxy-1,2-dioxines were ring-opened using triethylamine to yield 4-hydroxy-2,3-epoxy-ketones quantitatively, and meso-epoxy-1,2-dioxines were ring-opened using Co(II) salen complexes to afford 4-hydroxy-2,3-epoxy-ketones in 77-98% yield.	epoxy-1,2-dioxines	14-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	174-179
12816478-2	2003	Unsymmetrical epoxy-1,2-dioxines were ring-opened using triethylamine to yield 4-hydroxy-2,3-epoxy-ketones quantitatively, and meso-epoxy-1,2-dioxines were ring-opened using Co(II) salen complexes to afford 4-hydroxy-2,3-epoxy-ketones in 77-98% yield.	triethylamine	56-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	174-179
12816478-2	2003	Unsymmetrical epoxy-1,2-dioxines were ring-opened using triethylamine to yield 4-hydroxy-2,3-epoxy-ketones quantitatively, and meso-epoxy-1,2-dioxines were ring-opened using Co(II) salen complexes to afford 4-hydroxy-2,3-epoxy-ketones in 77-98% yield.	meso-epoxy-1,2-dioxines	127-150	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	174-179
12772922-1	2003	In the chiral Co(III)(salen)-catalysed HKR of racemic epoxides, in the presence of ionic liquids, Co(II)(salen) complex is oxidised without acetic acid to catalytically active Co(III)(salen) complex during reaction and, moreover, this oxidation state is stabilised against reduction to Co(II) complex which enables the reuse of the recovered catalyst for consecutive reactions without extra reoxidation.	Acetic Acid	140-151	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-104
14552704-6	2003	The improved biochemical selectivity of valdecoxib vs celecoxib in vitro (COX-1/COX-2 ratio: 60 vs 30, respectively) may be clinically relevant leading to an improved GI safety.	valdecoxib	40-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-85
12772009-1	2003	Cyclo-oxygenase (COX) exists in two isoforms, COX-1 and COX-2, that direct the synthesis of prostaglandins, prostacyclin and thromboxane.	Prostaglandins	92-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-61
12772009-1	2003	Cyclo-oxygenase (COX) exists in two isoforms, COX-1 and COX-2, that direct the synthesis of prostaglandins, prostacyclin and thromboxane.	Epoprostenol	108-120	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-61
12772009-1	2003	Cyclo-oxygenase (COX) exists in two isoforms, COX-1 and COX-2, that direct the synthesis of prostaglandins, prostacyclin and thromboxane.	Thromboxanes	125-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-61
12929571-2	2003	We examined the inhibitory effects of a novel selective COX-2 inhibitor, JTE-522 (JT), against gastric cancer cell lines (TMK-1, MKN-45 and MKN-74) alone and in combination with cisplatin (CDDP).	4-(4-cyclohexyl-2-methyloxazol-5-yl)-2-fluorobenzenesulfonamide	73-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-61
14552703-1	2003	Most carcinomas overexpress cyclooxygenase, especially COX-2, thus secreting large amounts of immunosuppressive prostaglandins.	Prostaglandins	112-126	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-60
12738747-3	2003	We investigated whether the COX-2-selective inhibitor NS398 induced growth inhibition in four human OSCC cell lines and whether this was COX-2 dependent.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	54-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
14610907-1	2003	Cyclooxygenase (COX)-2, an inducible enzyme involved in prostaglandin biosynthesis, has attracted considerable attention recently, due to its role in human cancer biology.	Prostaglandins	56-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-22
12800464-2	2003	Etoricoxib, a selective COX2 inhibitor, has been shown to be as effective as non-selective non-steroidal anti-inflammatory drugs in the management of chronic pain in rheumatoid arthritis and osteoarthritis, for periods of up to one year.	Etoricoxib	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-28
12800464-7	2003	However, etoricoxib shows promise as a new and effective COX2 inhibitor in clinical practice.	Etoricoxib	9-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-61
14552704-2	2003	Rofecoxib and celecoxib are the first selective COX-2 inhibitors approved by the FDA and EMEA for the treatment of rheumatoid arthritis (RA), osteoarthritis (OA) and for relief of acute pain.	rofecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-53
14552704-6	2003	The improved biochemical selectivity of valdecoxib vs celecoxib in vitro (COX-1/COX-2 ratio: 60 vs 30, respectively) may be clinically relevant leading to an improved GI safety.	Celecoxib	54-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-85
14552704-2	2003	Rofecoxib and celecoxib are the first selective COX-2 inhibitors approved by the FDA and EMEA for the treatment of rheumatoid arthritis (RA), osteoarthritis (OA) and for relief of acute pain.	Celecoxib	14-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-53
14552704-8	2003	Etoricoxib, showing only a slightly higher COX-2 selectivity than rofecoxib in vitro (COX-1/COX-2 ratio: 344 vs 272, respectively), has been reported to cause a similar specific COX-2 inhibition ex vivo that should translate into comparable GI safety.	Etoricoxib	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
14552704-5	2003	Recently, other selective COX-2 inhibitors with different COX-1/COX-2 selectivity and pharmacokinetic features have been developed, i.e. valdecoxib, parecoxib, etoricoxib and lumiracoxib.	valdecoxib	137-147	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-31
14552704-5	2003	Recently, other selective COX-2 inhibitors with different COX-1/COX-2 selectivity and pharmacokinetic features have been developed, i.e. valdecoxib, parecoxib, etoricoxib and lumiracoxib.	parecoxib	149-158	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-31
14552704-5	2003	Recently, other selective COX-2 inhibitors with different COX-1/COX-2 selectivity and pharmacokinetic features have been developed, i.e. valdecoxib, parecoxib, etoricoxib and lumiracoxib.	lumiracoxib	175-186	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-31
12721215-4	2003	There was a 2-nucleotide deletion in the mitochondrial COII genes, introducing a stop codon, which might be responsible for low sperm motility.	2-nucleotide	12-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-59
14552704-8	2003	Etoricoxib, showing only a slightly higher COX-2 selectivity than rofecoxib in vitro (COX-1/COX-2 ratio: 344 vs 272, respectively), has been reported to cause a similar specific COX-2 inhibition ex vivo that should translate into comparable GI safety.	Etoricoxib	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-97
14552704-8	2003	Etoricoxib, showing only a slightly higher COX-2 selectivity than rofecoxib in vitro (COX-1/COX-2 ratio: 344 vs 272, respectively), has been reported to cause a similar specific COX-2 inhibition ex vivo that should translate into comparable GI safety.	Etoricoxib	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-97
14552704-9	2003	Lumiracoxib, the most selective COX-2 inhibitor in vitro (COX-1/COX-2 ratio: 400), is the only acidic coxib.	lumiracoxib	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-37
12743579-3	2003	OBJECTIVE: We investigated whether 33 subjects with a typical history of AIA tolerated the new COX-2-selective NSAID celecoxib.	Celecoxib	117-126	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-100
14552704-9	2003	Lumiracoxib, the most selective COX-2 inhibitor in vitro (COX-1/COX-2 ratio: 400), is the only acidic coxib.	lumiracoxib	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-69
12743579-10	2003	CONCLUSIONS: A group of subjects with clinically well-documented AIA tolerated acute challenge with the selective COX-2 inhibitor celecoxib.	Celecoxib	130-139	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-119
14552705-12	2003	Similarly, whilst mRNA stability is clearly modulated by steroids in the case of COX-2, the wider implications of targeting mRNA stability have not been afforded the same attention.	Steroids	57-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-86
15199473-4	2003	Aspirin and salicylate at therapeutic concentrations inhibit COX-2 protein expression through interference with binding of CCAAT/enhancer binding protein beta (C/EBPbeta) to its cognate site on COX-2 promoter/enhancer.	Aspirin	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-66
12794878-4	2003	CAD of the metal complexes, especially [Co(II) (chalcone-H) 2,2"-bipyridine](+), allowed the most effective differentiation of the isomeric chalcones with several diagnostic fragment ions appearing upon activation of the metal complexes.	Metals	11-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-46
12794878-4	2003	CAD of the metal complexes, especially [Co(II) (chalcone-H) 2,2"-bipyridine](+), allowed the most effective differentiation of the isomeric chalcones with several diagnostic fragment ions appearing upon activation of the metal complexes.	chalcone-h) 2,2"-bipyridine	48-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-46
12794878-4	2003	CAD of the metal complexes, especially [Co(II) (chalcone-H) 2,2"-bipyridine](+), allowed the most effective differentiation of the isomeric chalcones with several diagnostic fragment ions appearing upon activation of the metal complexes.	Chalcones	140-149	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-46
12794878-4	2003	CAD of the metal complexes, especially [Co(II) (chalcone-H) 2,2"-bipyridine](+), allowed the most effective differentiation of the isomeric chalcones with several diagnostic fragment ions appearing upon activation of the metal complexes.	Metals	221-226	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-46
15199473-3	2003	Aspirin is less effective in inhibiting COX-2 activity, whereas celecoxib and rofecoxib selectively inhibit COX-2 activity as they contain a side chain to anchor to the side pocket of COX-2 substrate channel.	Aspirin	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
12751271-0	2003	The COX-2 selective inhibitor, valdecoxib, does not impair platelet function in the elderly: results of a randomized controlled trial.	valdecoxib	31-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
12751271-1	2003	The effects of the new cyclooxygenase (COX)-2 selective inhibitor, valdecoxib (40 mg bid; n = 17), on platelet function were evaluated, along with ibuprofen (800 mg tid; n = 15) and placebo (n = 15), in healthy elderly subjects (65-85 years) in this 7.5-day, randomized, single-center, double-blind study.	valdecoxib	67-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-45
15199473-3	2003	Aspirin is less effective in inhibiting COX-2 activity, whereas celecoxib and rofecoxib selectively inhibit COX-2 activity as they contain a side chain to anchor to the side pocket of COX-2 substrate channel.	Celecoxib	64-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-113
15199473-4	2003	Aspirin and salicylate at therapeutic concentrations inhibit COX-2 protein expression through interference with binding of CCAAT/enhancer binding protein beta (C/EBPbeta) to its cognate site on COX-2 promoter/enhancer.	Aspirin	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	194-199
15199473-3	2003	Aspirin is less effective in inhibiting COX-2 activity, whereas celecoxib and rofecoxib selectively inhibit COX-2 activity as they contain a side chain to anchor to the side pocket of COX-2 substrate channel.	Celecoxib	64-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-113
15199473-4	2003	Aspirin and salicylate at therapeutic concentrations inhibit COX-2 protein expression through interference with binding of CCAAT/enhancer binding protein beta (C/EBPbeta) to its cognate site on COX-2 promoter/enhancer.	Salicylates	12-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-66
15199473-3	2003	Aspirin is less effective in inhibiting COX-2 activity, whereas celecoxib and rofecoxib selectively inhibit COX-2 activity as they contain a side chain to anchor to the side pocket of COX-2 substrate channel.	rofecoxib	78-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-113
15199473-3	2003	Aspirin is less effective in inhibiting COX-2 activity, whereas celecoxib and rofecoxib selectively inhibit COX-2 activity as they contain a side chain to anchor to the side pocket of COX-2 substrate channel.	rofecoxib	78-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-113
15199473-4	2003	Aspirin and salicylate at therapeutic concentrations inhibit COX-2 protein expression through interference with binding of CCAAT/enhancer binding protein beta (C/EBPbeta) to its cognate site on COX-2 promoter/enhancer.	Salicylates	12-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	194-199
12767724-3	2003	Selective COX-2 inhibitors are effective anti-inflammatory agents with lower gastrointestinal toxicity than aspirin.	Aspirin	108-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
12941996-4	2003	These studies evaluated the efficacy and tolerability of rofecoxib, a selective COX-2 inhibitor, in the treatment of chronic low back pain.	rofecoxib	57-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-85
12691560-0	2003	Syntheses of two new 1D and 3D networks of Cu(II) and Co(II) using malonate and urotropine as bridging ligands: crystal structures and magnetic studies.	malonic acid	67-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-60
12717864-5	2003	RESULTS: Bile from APBDU can significantly promote the proliferation of human cholangiocarcinoma QBC939 cells compared with normal bile (P=0.005) and up-regulated remarkably their COX-2 mRNA expression (P=0.004).	apbdu	19-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	180-185
12717864-7	2003	CONCLUSION: Bile from APBDU can promote the proliferation of human cholangiocarcinoma QBC939 cells via COX-2 pathway.	apbdu	22-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-108
12717830-1	2003	AIM: To evaluate the potential role of Nimesulide, a selective COX-2 inhibitor, in proliferation and apoptosis of gastric adenocarcinoma cells SGC7901.	nimesulide	39-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-68
12772588-2	2003	Some compounds that have a lower alkyl group at the 2-position of the gamma-sultam skeleton showed potent inhibitory effects on both cyclooxygenase (COX)-2 and 5-lipoxygenase (5-LO), as well as production of interleukin-1 (IL-1) in in vitro assays.	gamma-sultam	70-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	133-155
12705835-6	2003	The electronic absorption spectrum of the Co(II)-substituted LuxS underwent dramatic catalysis-dependent changes, suggesting the direct involvement of the metal ion in catalysis.	Metals	155-160	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-49
12691588-7	2003	Intracellular chloride was clearly detectable by (35)Cl NMR spectroscopy in human skin fibroblast cells suspended in medium containing 40 mM Co(II)/gly SR. We determined that, although Co(2+)((aq)) provides a larger shift than Co(II)/gly at the same rho value, there are significant advantages for using Co(II)/gly, such as pH stability, ionic strength independent chemical shifts, narrow (35)Cl(-) NMR resonances, and reduced cellular toxicity, as a SR in biological systems.	Cobalt(2+)	185-191	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	227-233
12691588-7	2003	Intracellular chloride was clearly detectable by (35)Cl NMR spectroscopy in human skin fibroblast cells suspended in medium containing 40 mM Co(II)/gly SR. We determined that, although Co(2+)((aq)) provides a larger shift than Co(II)/gly at the same rho value, there are significant advantages for using Co(II)/gly, such as pH stability, ionic strength independent chemical shifts, narrow (35)Cl(-) NMR resonances, and reduced cellular toxicity, as a SR in biological systems.	Cobalt(2+)	185-191	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	227-233
12691560-0	2003	Syntheses of two new 1D and 3D networks of Cu(II) and Co(II) using malonate and urotropine as bridging ligands: crystal structures and magnetic studies.	Methenamine	80-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-60
12691560-3	2003	Complex 2 is a 3D coordination polymer made of pseudo-two-dimensional layers of Co(II) ions linked by malonate anions in syn-anti conformation which are bridged by bidentate urotropine in trans fashion.	Polymers	31-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-86
12691588-2	2003	Due to the relatively low thermodynamic stability of [Co(gly)(3)](-), a 1:3 Co(II)/gly stoichiometric solution at physiological pH is approximately a 2:1 mixture of [Co(gly)(2)(H(2)O)(2)] and [Co(gly)(H(2)O)(4)](+).	co(gly)(3)	54-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-82
12691588-2	2003	Due to the relatively low thermodynamic stability of [Co(gly)(3)](-), a 1:3 Co(II)/gly stoichiometric solution at physiological pH is approximately a 2:1 mixture of [Co(gly)(2)(H(2)O)(2)] and [Co(gly)(H(2)O)(4)](+).	Glycine	57-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-82
12691588-2	2003	Due to the relatively low thermodynamic stability of [Co(gly)(3)](-), a 1:3 Co(II)/gly stoichiometric solution at physiological pH is approximately a 2:1 mixture of [Co(gly)(2)(H(2)O)(2)] and [Co(gly)(H(2)O)(4)](+).	co(gly)(2)	166-176	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-82
12691588-2	2003	Due to the relatively low thermodynamic stability of [Co(gly)(3)](-), a 1:3 Co(II)/gly stoichiometric solution at physiological pH is approximately a 2:1 mixture of [Co(gly)(2)(H(2)O)(2)] and [Co(gly)(H(2)O)(4)](+).	co(gly)	54-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-82
12691588-6	2003	Line widths at half-height were significantly (p &lt; 0.05) less for Co(II)/gly than for Co(2+)((aq)) at rho values in the range 0.066-0.40.	Glycine	76-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-75
12691588-7	2003	Intracellular chloride was clearly detectable by (35)Cl NMR spectroscopy in human skin fibroblast cells suspended in medium containing 40 mM Co(II)/gly SR. We determined that, although Co(2+)((aq)) provides a larger shift than Co(II)/gly at the same rho value, there are significant advantages for using Co(II)/gly, such as pH stability, ionic strength independent chemical shifts, narrow (35)Cl(-) NMR resonances, and reduced cellular toxicity, as a SR in biological systems.	Chlorides	14-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	141-147
12691588-7	2003	Intracellular chloride was clearly detectable by (35)Cl NMR spectroscopy in human skin fibroblast cells suspended in medium containing 40 mM Co(II)/gly SR. We determined that, although Co(2+)((aq)) provides a larger shift than Co(II)/gly at the same rho value, there are significant advantages for using Co(II)/gly, such as pH stability, ionic strength independent chemical shifts, narrow (35)Cl(-) NMR resonances, and reduced cellular toxicity, as a SR in biological systems.	Chlorides	14-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	227-233
12691588-7	2003	Intracellular chloride was clearly detectable by (35)Cl NMR spectroscopy in human skin fibroblast cells suspended in medium containing 40 mM Co(II)/gly SR. We determined that, although Co(2+)((aq)) provides a larger shift than Co(II)/gly at the same rho value, there are significant advantages for using Co(II)/gly, such as pH stability, ionic strength independent chemical shifts, narrow (35)Cl(-) NMR resonances, and reduced cellular toxicity, as a SR in biological systems.	Chlorides	14-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	227-233
12628757-3	2003	In fact, here we show that acetyl-Tyr-Val-Ala-Asp-chloromethylketone (Ac-YVAD-CMK) and t-butoxycarbonyl-L-aspartic acid benzyl ester-chloromethylketone (Boc-Asp-(OBzl)-CMK), two inhibitors of Interleukin-1 Converting Enzyme (ICE; also referred to as caspase-1), abolish COX-2 expression enhanced by gp120 and consequent cell death.	N-acetyl-tyrosyl-valyl-alanyl-aspartyl chloromethyl ketone	27-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	270-275
12628757-4	2003	In addition, NS-398, a selective inhibitor of COX-2 activity, affords neuroprotection strengthening the role of COX-2 in the mechanisms of death.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	13-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
12682373-1	2003	A novel octahedral complex CoII(HAPP)(TFA)2 [hexaazaphenantholine-cyclophane (HAPP), trifluoroacetate (TFA)] is a DNA bulge-specific probe with single-strand DNA cleavage activity in the presence of H2O2.	6-Amino-1H-pyrazolo[3,4-d]pyrimidin-4(7H)-one	32-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-31
12682373-1	2003	A novel octahedral complex CoII(HAPP)(TFA)2 [hexaazaphenantholine-cyclophane (HAPP), trifluoroacetate (TFA)] is a DNA bulge-specific probe with single-strand DNA cleavage activity in the presence of H2O2.	Trifluoroacetic Acid	85-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-31
12682373-1	2003	A novel octahedral complex CoII(HAPP)(TFA)2 [hexaazaphenantholine-cyclophane (HAPP), trifluoroacetate (TFA)] is a DNA bulge-specific probe with single-strand DNA cleavage activity in the presence of H2O2.	Trifluoroacetic Acid	38-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-31
12682373-1	2003	A novel octahedral complex CoII(HAPP)(TFA)2 [hexaazaphenantholine-cyclophane (HAPP), trifluoroacetate (TFA)] is a DNA bulge-specific probe with single-strand DNA cleavage activity in the presence of H2O2.	Hydrogen Peroxide	199-203	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-31
12682373-5	2003	Cleavage specificity of CoII(HAPP)(TFA)2 was characterized extensively using scavenger reagents to quench the cleavage reaction and high-resolution polyacrylamide gel electrophoresis.	polyacrylamide	148-162	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-28
12628642-0	2003	Synthesis and biological evaluation of substituted 2-sulfonyl-phenyl-3-phenyl-indoles: a new series of selective COX-2 inhibitors.	2-sulfonyl-phenyl-3-phenyl-indoles	51-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-118
12628642-1	2003	A new series of substituted 2-sulfonyphenyl-3-phenyl-indole derivatives were synthesized and evaluated for their ability to inhibit COX-2 and COX-1enzymes.	2-sulfonyphenyl-3-phenyl-indole	28-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-137
12628642-3	2003	This work led to the discovery of 2-aminosulfonylphenyl-3-phenyl-indole 5a which possesses higher activity and selectivity for COX-2 than Celecoxib both in vitro and in vivo.	2-aminosulfonylphenyl-3-phenyl-indole	34-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	127-132
12628757-4	2003	In addition, NS-398, a selective inhibitor of COX-2 activity, affords neuroprotection strengthening the role of COX-2 in the mechanisms of death.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	13-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-117
12628757-3	2003	In fact, here we show that acetyl-Tyr-Val-Ala-Asp-chloromethylketone (Ac-YVAD-CMK) and t-butoxycarbonyl-L-aspartic acid benzyl ester-chloromethylketone (Boc-Asp-(OBzl)-CMK), two inhibitors of Interleukin-1 Converting Enzyme (ICE; also referred to as caspase-1), abolish COX-2 expression enhanced by gp120 and consequent cell death.	t-butoxycarbonyl-l-aspartic acid benzyl ester	87-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	270-275
12628757-3	2003	In fact, here we show that acetyl-Tyr-Val-Ala-Asp-chloromethylketone (Ac-YVAD-CMK) and t-butoxycarbonyl-L-aspartic acid benzyl ester-chloromethylketone (Boc-Asp-(OBzl)-CMK), two inhibitors of Interleukin-1 Converting Enzyme (ICE; also referred to as caspase-1), abolish COX-2 expression enhanced by gp120 and consequent cell death.	chloromethylketone	50-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	270-275
12684433-7	2003	EXPERIMENTAL DESIGN: The COX-2 inhibitor SC-236 was combined with the selective EGFR tyrosine kinase inhibitor ZD1839 (Iressa) and the DNA/RNA-mixed backbone oligonucleotide AS-PKAI to study their effect on human cancer growth and angiogenesis, measuring vascular endothelial growth factor (VEGF) and basic fibroblast growth factor expression and vessel formation, in vitro and after oral administration of these agents in mice.	4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide	41-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-30
12648158-3	2003	The two COX isoforms, COX-1 (constitutive form) and COX-2 (inducible form) are both abundantly expressed in renal inner medulla at basal state, raising a question of which COX isoform may mediate the known functions of PGs in the region.	Prostaglandins	219-222	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-57
12648158-5	2003	In contrast, COX-2 expression in renal medulla is markedly stimulated by chronic salt loading, dehydration and endotoxaemia in vivo.	Salts	81-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
12648158-7	2003	It is likely that in response to various insults that are detrimental to renal medulla, the induction of PG synthesis may become more dependent on COX-2 than COX-1, and this phenomenon may be relevant to the cytoprotective response against the insults.	Prostaglandins	105-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-152
12648159-3	2003	Physiological regulation of COX-2 in these cellular compartments suggests functional roles for eicosanoid products of the enzyme.	Eicosanoids	95-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
12648159-4	2003	In the MD region, COX-2 expression increases in high renin states [salt restriction, angiotensin converting enzyme (ACE) inhibition, renovascular hypertension], and selective COX-2 inhibitors significantly decrease plasma renin levels and renal renin activity and mRNA expression.	Salts	67-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-23
12725391-1	2003	In the absence of any special luminescent reagents, a weakly chemiluminescent emission was observed during the decomposition of hydrogen peroxide, catalyzed by transition-metal ions, such as Cu(II) and Co(II), in basic aqueous solution.	Hydrogen Peroxide	128-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	202-208
12725391-1	2003	In the absence of any special luminescent reagents, a weakly chemiluminescent emission was observed during the decomposition of hydrogen peroxide, catalyzed by transition-metal ions, such as Cu(II) and Co(II), in basic aqueous solution.	Metals	171-176	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	202-208
12725391-6	2003	After ion chromatographic separation of Cu(II) and Co(II) by an IonPac CS5A column with oxalic acid and lithium hydroxide monohydrate as the eluent, the present chemiluminescent system was used as a post-column detector for these two transition metal ions in natural water samples.	Oxalic Acid	88-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-57
12733020-1	2003	A solid-phase reagent based on 1-(4-adamantyl-2-thiasolylazo)-2-naphthol adsorbed onto silica gel was prepared for Co(II) recovery and preconcentration prior to its sorption-spectroscopic detection.	1-(4-adamantyl-2-thiasolylazo)-2-naphthol	31-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-121
12733020-1	2003	A solid-phase reagent based on 1-(4-adamantyl-2-thiasolylazo)-2-naphthol adsorbed onto silica gel was prepared for Co(II) recovery and preconcentration prior to its sorption-spectroscopic detection.	Silicon Dioxide	87-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-121
12651810-14	2003	However, the Co(II)-albumin binding was a poor discriminator between ischemic individuals with and without MI.	2-methyl-4-isothiazolin-3-one	107-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-19
12655261-0	2003	Effects of selective COX-2 inhibitors on the gastric permeability of sucrose: a controlled study with placebo and ibuprofen.	Sucrose	69-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-26
12668898-5	2003	Furthermore, for patients with AERD and chronic urticaria, they can be given the new selective COX-2 inhibitors (rofecoxib and celecoxib) without any cross-reactivity.	rofecoxib	113-122	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-100
12668898-5	2003	Furthermore, for patients with AERD and chronic urticaria, they can be given the new selective COX-2 inhibitors (rofecoxib and celecoxib) without any cross-reactivity.	Celecoxib	127-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-100
12961891-0	2003	[Study on extraction separation of Bi(III), Fe(III), Cu(II), Ni(II), Co(II) and Pb(II) in PEG-(NH4)2SO4-PR system using spectrophotometry].	peg-(nh4)2so4	90-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-75
12961891-1	2003	In polyethylene PEG-(NH4)2SO4-PR system the extraction separation behaviour of the complexes of Bi(III), Fe(III), Cu(II), Ni(II), Co(II) and Pb(II) was investigated.	polyethylene peg-(nh4)2so4	3-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	130-136
12961891-3	2003	So Bi(III) (pH 3.5) and Fe(III) (pH 5.0) were quantitatively separated from the mixed solution of Bi(III), Fe(III), Cu(II), Co(II), Pb(II) and Ni(II) ions.	bi(iii)	3-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	124-130
12961891-3	2003	So Bi(III) (pH 3.5) and Fe(III) (pH 5.0) were quantitatively separated from the mixed solution of Bi(III), Fe(III), Cu(II), Co(II), Pb(II) and Ni(II) ions.	ferric sulfate	24-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	124-130
12961891-1	2003	In polyethylene PEG-(NH4)2SO4-PR system the extraction separation behaviour of the complexes of Bi(III), Fe(III), Cu(II), Ni(II), Co(II) and Pb(II) was investigated.	Praseodymium	30-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	130-136
12723742-3	2003	COX-2 inhibitors such as celecoxib and rofecoxib appear to be as effective as non-selective NSAIDs in the treatment of chronic inflammatory disease but their analgesic efficacy and their safety at the higher doses required for analgesia are less certain.	Celecoxib	25-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
12657620-8	2003	RESULTS: Vitreous treatment of RPE cells resulted in increased expression of two critical enzymes in the synthesis of prostaglandin E(2): membrane-associated prostaglandin E-synthase (mPGES) and cyclooxygenase (COX)-2.	Dinoprostone	118-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	195-217
12797547-0	2003	The cox-2-specific inhibitor celecoxib inhibits adenylyl cyclase.	Celecoxib	29-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
12797547-3	2003	Celecoxib (Celebrex) is a COX-2 enzyme inhibitor and has emerged as a preferred therapeutic agent for the treatment of rheumatoid arthritis as compared to other NSAIDs.	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-31
12797547-3	2003	Celecoxib (Celebrex) is a COX-2 enzyme inhibitor and has emerged as a preferred therapeutic agent for the treatment of rheumatoid arthritis as compared to other NSAIDs.	Celecoxib	11-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-31
12797547-5	2003	In the present study, we report that celecoxib not only inhibited COX-2, but also exhibited the property of inhibiting adenylyl cyclase, an important enzyme forming the intracellular second messenger 3",5"-adenosine monophosphate (cAMP) from adenosine triphosphate (ATP).	Celecoxib	37-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-71
12723742-3	2003	COX-2 inhibitors such as celecoxib and rofecoxib appear to be as effective as non-selective NSAIDs in the treatment of chronic inflammatory disease but their analgesic efficacy and their safety at the higher doses required for analgesia are less certain.	rofecoxib	39-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
12723745-4	2003	Of the cyclo-oxygenase (COX)-2 selective NSAIDs, rofecoxib is associated with a lower risk of gastrointestinal toxicity but there is uncertainty about the long-term risk associated with celecoxib.	rofecoxib	49-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	7-30
12841340-10	2003	In addition, PMA stimulates PGE2 production via up-regulation of COX-1, and likely COX-2, expression in U937 cells whereas LPS stimulates PGE2 production via induction of COX-2 expression in macrophages.	Dinoprostone	28-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
12677571-2	2003	Cyclooxygenase (COX) is a key enzyme in the synthesis of prostaglandins, and 2 isoforms have been identified: COX-1 and COX-2.	Prostaglandins	57-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-125
12644588-4	2003	The affinity of [(3)H]celecoxib for COX-2 (K(D) = 2.3 nM) was similar to the affinity of [(3)H]valdecoxib (K(D) = 3.2 nM).	[(3)h]celecoxib	16-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-41
12644588-5	2003	The binding to COX-2 seems to be both rapid and slowly reversible with association rates of 5.8 x 10(6)/M/min and 4.5 x 10(6)/M/min and dissociation rates of 14 x 10(-3)/min (t(1/2) = 50 min) and 7.0 x 10(-3)/min (t(1/2) = 98 min) for [(3)H]celecoxib and [(3)H]valdecoxib, respectively.	Celecoxib	241-250	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-20
12644588-5	2003	The binding to COX-2 seems to be both rapid and slowly reversible with association rates of 5.8 x 10(6)/M/min and 4.5 x 10(6)/M/min and dissociation rates of 14 x 10(-3)/min (t(1/2) = 50 min) and 7.0 x 10(-3)/min (t(1/2) = 98 min) for [(3)H]celecoxib and [(3)H]valdecoxib, respectively.	valdecoxib	261-271	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-20
12644588-9	2003	These binding studies provide direct insight into the properties and binding constants of celecoxib and valdecoxib to COX-2.	Celecoxib	90-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-123
12644588-9	2003	These binding studies provide direct insight into the properties and binding constants of celecoxib and valdecoxib to COX-2.	valdecoxib	104-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-123
12743620-3	2003	When added to the samples, arachidonic acid activates the synthesis of COX-2.	Arachidonic Acid	27-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-76
12868201-3	2003	Slow, time-dependent, irreversible, highly selective inhibitors of COX-2 such as celecoxib, etoricoxib, rofecoxib and valdecoxib, so-called coxibs, are a new group of drugs widely used in rheumatology as well as in other fields of medicine.	Celecoxib	81-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-72
12644391-23	2003	Thus, PTX, when given at doses comparable to those used in man for treatment of circulatory disorders displayed anti-inflammatory in vivo and enhanced the anti-inflammatory effect of a selective COX-2 inhibitor or dexamethasone.	Pentoxifylline	6-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	195-200
12868201-3	2003	Slow, time-dependent, irreversible, highly selective inhibitors of COX-2 such as celecoxib, etoricoxib, rofecoxib and valdecoxib, so-called coxibs, are a new group of drugs widely used in rheumatology as well as in other fields of medicine.	Etoricoxib	92-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-72
12868201-3	2003	Slow, time-dependent, irreversible, highly selective inhibitors of COX-2 such as celecoxib, etoricoxib, rofecoxib and valdecoxib, so-called coxibs, are a new group of drugs widely used in rheumatology as well as in other fields of medicine.	rofecoxib	104-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-72
12868201-3	2003	Slow, time-dependent, irreversible, highly selective inhibitors of COX-2 such as celecoxib, etoricoxib, rofecoxib and valdecoxib, so-called coxibs, are a new group of drugs widely used in rheumatology as well as in other fields of medicine.	valdecoxib	118-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-72
12720152-2	2003	Although its molecular mechanisms of action have not yet been elucidated, thalidomide and the IMiDs affect a variety of cytokines and inflammatory mediators including tumor necrosis factor-alpha (TNFalpha), interleukin (IL)-1beta, interferon gamma (IFNgamma), IL-6, IL-10, IL-12, and COX-2 and angiogenesis factors such as vascular endothelial growth factor (VEGF) and its receptor.	Thalidomide	74-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	284-289
12618325-6	2003	The possibility of COX-2 as a candidate player in cancer development and progression evolved from the epidemiological studies which suggest that regular use of aspirin or other non-steroidal anti-inflammatory drugs could significantly decrease the risk of developing cancers in experimental animals and in humans.	Aspirin	160-167	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-24
15139149-9	2003	CONCLUSION: In contrast with indomethacin, Sinomenine shows a preferential inhibitory effect on COX-2 over COX-1, These results suggest that Sinomenine is a selective COX-2 inhibitor, which may be directly related to suppressing cyclooxygenase activity.	sinomenine	43-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-101
15139149-9	2003	CONCLUSION: In contrast with indomethacin, Sinomenine shows a preferential inhibitory effect on COX-2 over COX-1, These results suggest that Sinomenine is a selective COX-2 inhibitor, which may be directly related to suppressing cyclooxygenase activity.	sinomenine	43-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	167-172
15139149-9	2003	CONCLUSION: In contrast with indomethacin, Sinomenine shows a preferential inhibitory effect on COX-2 over COX-1, These results suggest that Sinomenine is a selective COX-2 inhibitor, which may be directly related to suppressing cyclooxygenase activity.	sinomenine	141-151	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-101
15139149-9	2003	CONCLUSION: In contrast with indomethacin, Sinomenine shows a preferential inhibitory effect on COX-2 over COX-1, These results suggest that Sinomenine is a selective COX-2 inhibitor, which may be directly related to suppressing cyclooxygenase activity.	sinomenine	141-151	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	167-172
12611530-5	2003	The complexation reactions of pyda, phendc.H(2), and LH(2) with H(+) as well as LH(2) with Co(II) in aqueous solution were investigated by potentiometric pH titrations, and the equilibrium constants for all major complexes formed are described.	lh(2)	80-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-97
15139149-0	2003	[The effect of sinomenine on cyclooxygenase activity and the expression of COX-1 and COX-2 mRNA in human peripheral monocytes].	sinomenine	15-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-90
15139149-1	2003	OBJECTIVE: To observe in vitro the effect of Sinomenine, a pure alkaloid extracted from the chinese medical plant Sinomenium acutum on the activity of cyclooxygenase (COX-1 and COX-2) and the expression of COX-1 and COX-2 mRNA.	sinomenine	45-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	177-182
15139149-1	2003	OBJECTIVE: To observe in vitro the effect of Sinomenine, a pure alkaloid extracted from the chinese medical plant Sinomenium acutum on the activity of cyclooxygenase (COX-1 and COX-2) and the expression of COX-1 and COX-2 mRNA.	sinomenine	45-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	216-221
15139149-5	2003	And by RT-PCR, both COX-1 and COX-2 mRNAs were detected in Mononuclear leukocytes after incubation for different hours with drug (sinomenine or indomethacin) or not.	sinomenine	130-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-35
15139149-5	2003	And by RT-PCR, both COX-1 and COX-2 mRNAs were detected in Mononuclear leukocytes after incubation for different hours with drug (sinomenine or indomethacin) or not.	Indomethacin	144-156	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-35
15139149-6	2003	RESULT: LPS (stimulated) induced the production of PGE2 in PBMC increasing with high expression of COX-2 mRNA; sinomenine reduced PGE2 production in LPS stimulated human monocytes more than in non-stimulated human monocytes.	Dinoprostone	51-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-104
15139149-6	2003	RESULT: LPS (stimulated) induced the production of PGE2 in PBMC increasing with high expression of COX-2 mRNA; sinomenine reduced PGE2 production in LPS stimulated human monocytes more than in non-stimulated human monocytes.	sinomenine	111-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-104
12646188-1	2003	Nitric oxide (NO) regulates differentiation, survival, and cyclooxygenase (COX)-2 expression in articular chondrocytes.	Nitric Oxide	0-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-81
12654603-8	2003	Plaques from the simvastatin group had fewer (P&lt;0.0001) macrophages, T-lymphocytes, and HLA-DR+ cells; less (P&lt;0.0001) immunoreactivity for COX-2/mPGES and MMPs; reduced (P&lt;0.0001) gelatinolytic activity; increased (P&lt;0.0001) collagen content; and reduced (P&lt;0.0001) lipid and oxLDL content.	Simvastatin	17-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	146-151
12654603-9	2003	Interestingly, COX-2/mPGES inhibition by simvastatin was completely reversed by mevalonate in vitro.	Simvastatin	41-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-20
12654603-9	2003	Interestingly, COX-2/mPGES inhibition by simvastatin was completely reversed by mevalonate in vitro.	Mevalonic Acid	80-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-20
12654603-10	2003	CONCLUSIONS: This study demonstrates that simvastatin decreases inflammation and inhibits COX-2/mPGES expression in plaque macrophages, and this effect in turn may contribute to plaque stabilization by inhibition of MMP-induced plaque rupture.	Simvastatin	42-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-95
12642362-5	2003	However, in the latter, the specific COX-2 inhibitor N-(2-cyclohexyloxy-4-nitrophenyl) methanesulfonamide significantly attenuated norepinephrine-induced vasoconstriction.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	53-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-42
12642362-5	2003	However, in the latter, the specific COX-2 inhibitor N-(2-cyclohexyloxy-4-nitrophenyl) methanesulfonamide significantly attenuated norepinephrine-induced vasoconstriction.	Norepinephrine	131-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-42
12663496-6	2003	However, stimulation of COX-2 activity by IL-1 beta resulted in a decrease in cell proliferation and an induction of cytotoxicity by AA as well as by EPA.	Eicosapentaenoic Acid	150-153	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
12654561-9	2003	In vitro cytocidal effect analysis confirmed that the RGD-modified, cox-2 (M and L) driven vectors showed a stronger cytocidal effect upon gancyclovir administration than the vectors with wild-type fiber.	Ganciclovir	139-150	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-73
12852704-1	2003	BACKGROUND: Traditional nonsteroidal anti-inflammatory drugs (NSAIDs) such as diclofenac, ibuprofen, naproxen, and related agents are nonselective inhibitors of both cyclooxygenase-1 (COX-1) and COX-2, which catalyze prostaglandin synthesis.	Diclofenac	78-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	195-200
12852704-1	2003	BACKGROUND: Traditional nonsteroidal anti-inflammatory drugs (NSAIDs) such as diclofenac, ibuprofen, naproxen, and related agents are nonselective inhibitors of both cyclooxygenase-1 (COX-1) and COX-2, which catalyze prostaglandin synthesis.	Ibuprofen	90-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	195-200
12852704-1	2003	BACKGROUND: Traditional nonsteroidal anti-inflammatory drugs (NSAIDs) such as diclofenac, ibuprofen, naproxen, and related agents are nonselective inhibitors of both cyclooxygenase-1 (COX-1) and COX-2, which catalyze prostaglandin synthesis.	Naproxen	101-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	195-200
12852704-1	2003	BACKGROUND: Traditional nonsteroidal anti-inflammatory drugs (NSAIDs) such as diclofenac, ibuprofen, naproxen, and related agents are nonselective inhibitors of both cyclooxygenase-1 (COX-1) and COX-2, which catalyze prostaglandin synthesis.	Prostaglandins	217-230	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	195-200
12852704-4	2003	OBJECTIVE: This article reviews available information on the new COX-2-selective inhibitor valdecoxib, including its clinical pharmacology, pharmacokinetics, adverse effects, potential drug interactions, and contraindications and warnings.	valdecoxib	91-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-70
12852704-19	2003	As with the other COX-2-selective inhibitors (celecoxib and rofecoxib), valdecoxib appears to produce less gastrointestinal toxicity than conventional nonselective NSAIDs, although some of the relevant clinical studies have been published only as abstracts.	valdecoxib	72-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-23
12623985-7	2003	Of note, prostaglandin synthesis by lysates of endothelial cells stimulated with heme or Ang II appear to involve COX-2, because it was blunted by NS-398, which is presumed to inhibit COX-2 specifically.	Prostaglandins	9-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-119
12623985-7	2003	Of note, prostaglandin synthesis by lysates of endothelial cells stimulated with heme or Ang II appear to involve COX-2, because it was blunted by NS-398, which is presumed to inhibit COX-2 specifically.	Prostaglandins	9-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	184-189
12623985-7	2003	Of note, prostaglandin synthesis by lysates of endothelial cells stimulated with heme or Ang II appear to involve COX-2, because it was blunted by NS-398, which is presumed to inhibit COX-2 specifically.	Heme	81-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-119
12623985-7	2003	Of note, prostaglandin synthesis by lysates of endothelial cells stimulated with heme or Ang II appear to involve COX-2, because it was blunted by NS-398, which is presumed to inhibit COX-2 specifically.	Heme	81-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	184-189
12669881-3	2003	COX-2 is an inducible enzyme believed to be responsible for PG synthesis at site of inflammation.	Prostaglandins	60-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
12669881-10	2003	COX-2 may play an important role in the regulation of prostanoid formation in the pathogenesis of pulpal inflammation.	Prostaglandins	54-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
14987412-10	2003	In vascular disease, there is increased expression of both COX-1 and COX-2, resulting in enhanced prostaglandin generation.	Prostaglandins	98-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-74
12633561-3	2003	METHOD: Expression of COX-2 in 67 stage 1 NSCLC paraffin-embedded tumor samples was determined by immunohistochemistry (IHC).	Paraffin	48-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-27
12633561-7	2003	After stimulation with PMA, n-BT, PAF and n-BT + PAF, the COX-2 expression in NSCLC cells was significantly increased in all cell lines.	Tetradecanoylphorbol Acetate	23-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
12633561-7	2003	After stimulation with PMA, n-BT, PAF and n-BT + PAF, the COX-2 expression in NSCLC cells was significantly increased in all cell lines.	n-bt	28-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
12633561-7	2003	After stimulation with PMA, n-BT, PAF and n-BT + PAF, the COX-2 expression in NSCLC cells was significantly increased in all cell lines.	Platelet Activating Factor	34-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
12633561-7	2003	After stimulation with PMA, n-BT, PAF and n-BT + PAF, the COX-2 expression in NSCLC cells was significantly increased in all cell lines.	n-bt	42-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
12633561-7	2003	After stimulation with PMA, n-BT, PAF and n-BT + PAF, the COX-2 expression in NSCLC cells was significantly increased in all cell lines.	Platelet Activating Factor	49-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
12633561-8	2003	CONCLUSIONS: The expression of COX-2 in NSCLC cells is high and was up-regulated by PMA, n-BT and PAF.	Tetradecanoylphorbol Acetate	84-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-36
12633561-8	2003	CONCLUSIONS: The expression of COX-2 in NSCLC cells is high and was up-regulated by PMA, n-BT and PAF.	n-bt	89-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-36
12633561-8	2003	CONCLUSIONS: The expression of COX-2 in NSCLC cells is high and was up-regulated by PMA, n-BT and PAF.	Platelet Activating Factor	98-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-36
12604692-1	2003	Rofecoxib is a selective cyclooxygenase (COX)-2 inhibitor approved for the treatment of pain and inflammation in rheumatoid and osteoarthritis.	rofecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-47
12581384-2	2003	Cyclooxygenase (COX)-2 is an inducible enzyme responsible for prostaglandin synthesis in certain inflammatory diseases.	Prostaglandins	62-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-22
12581384-9	2003	However, when the cells were treated with 80 micro g/ml arecoline, COX-2 expression was up-regulated as early as half an hour.	Arecoline	56-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-72
12581384-10	2003	This indicates that COX-2 expression is an early cellular response and regulated by arecoline at transcriptional level.	Arecoline	84-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-25
12581384-11	2003	In addition, pre-treatment with glutathione (GSH) precursor, 2-oxothiazolidine-4-carboxylic acid (OTZ), led to a decrease in induction of COX-2 mRNA by arecoline.	Glutathione	32-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	138-143
12581384-11	2003	In addition, pre-treatment with glutathione (GSH) precursor, 2-oxothiazolidine-4-carboxylic acid (OTZ), led to a decrease in induction of COX-2 mRNA by arecoline.	Glutathione	45-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	138-143
12581384-11	2003	In addition, pre-treatment with glutathione (GSH) precursor, 2-oxothiazolidine-4-carboxylic acid (OTZ), led to a decrease in induction of COX-2 mRNA by arecoline.	2-oxothiazolidine-4-carboxylic acid	61-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	138-143
12581384-11	2003	In addition, pre-treatment with glutathione (GSH) precursor, 2-oxothiazolidine-4-carboxylic acid (OTZ), led to a decrease in induction of COX-2 mRNA by arecoline.	2-oxothiazolidine-4-carboxylic acid	98-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	138-143
12581384-11	2003	In addition, pre-treatment with glutathione (GSH) precursor, 2-oxothiazolidine-4-carboxylic acid (OTZ), led to a decrease in induction of COX-2 mRNA by arecoline.	Arecoline	152-161	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	138-143
12581384-12	2003	GSH synthesis inhibitor, buthionine sulfoximine (BSO), was found to increase arecoline-induced COX-2 mRNA levels.	Glutathione	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-100
12581384-12	2003	GSH synthesis inhibitor, buthionine sulfoximine (BSO), was found to increase arecoline-induced COX-2 mRNA levels.	Buthionine Sulfoximine	25-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-100
12622739-0	2003	Transcriptional regulation of COX-2: a key mechanism in the pathogenesis of nasal polyposis in aspirin-sensitive asthmatics?	Aspirin	95-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-35
12581384-12	2003	GSH synthesis inhibitor, buthionine sulfoximine (BSO), was found to increase arecoline-induced COX-2 mRNA levels.	Buthionine Sulfoximine	49-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-100
12581384-12	2003	GSH synthesis inhibitor, buthionine sulfoximine (BSO), was found to increase arecoline-induced COX-2 mRNA levels.	Arecoline	77-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-100
12581384-15	2003	CONCLUSIONS: Taken together, these results suggest that COX-2 expression is significantly up-regulated in OSF tissues from areca quid chewers and arecoline may among other constituents be responsible for the enhanced COX-2 expression in vivo.	Arecoline	146-155	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	217-222
12581384-16	2003	The regulation of COX-2 expression induced by arecoline is critically dependent on the cellular GSH concentration.	Arecoline	46-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-23
12581384-16	2003	The regulation of COX-2 expression induced by arecoline is critically dependent on the cellular GSH concentration.	Glutathione	96-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-23
12600916-4	2003	Glucose selectively increased mRNA and protein expression of COX-2.	Glucose	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-66
12600916-8	2003	Phorbol ester caused an increase of COX-2 and endothelial NO synthase expression similar to that elicited by glucose.	Phorbol Esters	0-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-41
12600916-13	2003	CONCLUSIONS: Thus, high glucose, via PKC signaling, induces oxidative stress and upregulation of COX-2, resulting in reduced NO availability and altered prostanoid profile.	Glucose	24-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
12600916-13	2003	CONCLUSIONS: Thus, high glucose, via PKC signaling, induces oxidative stress and upregulation of COX-2, resulting in reduced NO availability and altered prostanoid profile.	Prostaglandins	153-163	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
12578976-0	2003	Differential effects of prostaglandin derived from omega-6 and omega-3 polyunsaturated fatty acids on COX-2 expression and IL-6 secretion.	Prostaglandins	24-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-107
12578976-0	2003	Differential effects of prostaglandin derived from omega-6 and omega-3 polyunsaturated fatty acids on COX-2 expression and IL-6 secretion.	omega-6	51-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-107
12578976-0	2003	Differential effects of prostaglandin derived from omega-6 and omega-3 polyunsaturated fatty acids on COX-2 expression and IL-6 secretion.	Phospholipids	63-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-107
12578976-5	2003	In this study, we compared the effects of PGE(2) and PGE(3) on (i) cell proliferation in NIH 3T3 fibroblasts, (ii) expression and transcriptional regulation of the COX-2 gene in NIH 3T3 fibroblasts, and (iii) the production of an inflammatory cytokine, IL-6, in RAW 264.7 macrophages.	Prostaglandins E	42-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	164-169
12578976-5	2003	In this study, we compared the effects of PGE(2) and PGE(3) on (i) cell proliferation in NIH 3T3 fibroblasts, (ii) expression and transcriptional regulation of the COX-2 gene in NIH 3T3 fibroblasts, and (iii) the production of an inflammatory cytokine, IL-6, in RAW 264.7 macrophages.	Prostaglandins E	53-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	164-169
12578976-7	2003	PGE(2) and PGE(3) both induce COX-2 mRNA via similar signaling mechanisms; however, compared with PGE(2), PGE(3) is significantly less efficient in inducing COX-2 gene expression.	Prostaglandins E	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-35
12578976-7	2003	PGE(2) and PGE(3) both induce COX-2 mRNA via similar signaling mechanisms; however, compared with PGE(2), PGE(3) is significantly less efficient in inducing COX-2 gene expression.	Prostaglandins E	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	157-162
12578976-7	2003	PGE(2) and PGE(3) both induce COX-2 mRNA via similar signaling mechanisms; however, compared with PGE(2), PGE(3) is significantly less efficient in inducing COX-2 gene expression.	Prostaglandins E	11-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-35
12578976-7	2003	PGE(2) and PGE(3) both induce COX-2 mRNA via similar signaling mechanisms; however, compared with PGE(2), PGE(3) is significantly less efficient in inducing COX-2 gene expression.	Prostaglandins E	11-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	157-162
12578976-7	2003	PGE(2) and PGE(3) both induce COX-2 mRNA via similar signaling mechanisms; however, compared with PGE(2), PGE(3) is significantly less efficient in inducing COX-2 gene expression.	Prostaglandins E	11-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-35
12578976-7	2003	PGE(2) and PGE(3) both induce COX-2 mRNA via similar signaling mechanisms; however, compared with PGE(2), PGE(3) is significantly less efficient in inducing COX-2 gene expression.	Prostaglandins E	11-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	157-162
12578976-7	2003	PGE(2) and PGE(3) both induce COX-2 mRNA via similar signaling mechanisms; however, compared with PGE(2), PGE(3) is significantly less efficient in inducing COX-2 gene expression.	Prostaglandins E	11-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-35
12578976-7	2003	PGE(2) and PGE(3) both induce COX-2 mRNA via similar signaling mechanisms; however, compared with PGE(2), PGE(3) is significantly less efficient in inducing COX-2 gene expression.	Prostaglandins E	11-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	157-162
12565941-1	2003	A new series of cyclooxygenase-2(COX-2) inhibitors with naturally occurring flavone as the main skeleton has been synthesized and their biological activities were evaluated for cyclooxygenase inhibitory activity.	flavone	76-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-38
12854029-11	2003	Prostamides are naturally occurring substances, biosynthesized from anandamide in a pathway that includes COX2.	Bimatoprost	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-110
18968936-2	2003	This method is based on the difference of the chemical reaction rate of V(IV) and Co(II) with Fe(III) in the presence of chromogenic reagent, 1,10-phenanthroline.	ferric sulfate	94-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-88
18968936-2	2003	This method is based on the difference of the chemical reaction rate of V(IV) and Co(II) with Fe(III) in the presence of chromogenic reagent, 1,10-phenanthroline.	1,10-phenanthroline	142-161	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-88
18968936-3	2003	The reduced product of the reaction, Fe(II), can form a colored complex with 1,10-phenanthroline and make a visible spectrophotometric signal for indirect monitoring of the V(IV) and Co(II) concentrations.	ammonium ferrous sulfate	37-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	183-189
18968936-3	2003	The reduced product of the reaction, Fe(II), can form a colored complex with 1,10-phenanthroline and make a visible spectrophotometric signal for indirect monitoring of the V(IV) and Co(II) concentrations.	1,10-phenanthroline	77-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	183-189
12588166-8	2003	The phosphine oxide derivatives act as bidentate ligands and form chelate complexes with Co(II), Mo(VI), Th(IV), and U(VI) derivatives.	Phosphine oxide	4-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-95
14983832-2	2003	Cobalt impregnated alginate beads are first formed by extrusion of an aqueous suspension of Co3O4 into a Co(II) chloride solution.	Cobalt	0-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-111
14983832-2	2003	Cobalt impregnated alginate beads are first formed by extrusion of an aqueous suspension of Co3O4 into a Co(II) chloride solution.	Alginates	19-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-111
12591723-2	2003	Tumor COX-2-dependent production of PGE(2) triggers the synthesis of lymphocyte and macrophage interleukin (IL)-10 that, in turn, is known to potently suppress COX-2 in normal cells.	Prostaglandins E	36-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	6-11
12591723-2	2003	Tumor COX-2-dependent production of PGE(2) triggers the synthesis of lymphocyte and macrophage interleukin (IL)-10 that, in turn, is known to potently suppress COX-2 in normal cells.	Prostaglandins E	36-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	160-165
12553811-1	2003	15N NMR of DNA containing 15N-N7-enriched guanine (G) in the presence of paramagnetic ions (Mn(II) and Co(II)) was investigated.	15n	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-109
12553811-1	2003	15N NMR of DNA containing 15N-N7-enriched guanine (G) in the presence of paramagnetic ions (Mn(II) and Co(II)) was investigated.	15n	26-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-109
12553811-1	2003	15N NMR of DNA containing 15N-N7-enriched guanine (G) in the presence of paramagnetic ions (Mn(II) and Co(II)) was investigated.	4-(4-fluorophenyl)-2-methyl-6-(5-piperidinopentyloxy)pyrimidine hydrochloride	30-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-109
12574649-0	2003	Bis(2,6-bis[3-(2,4,6-trimethylphenyl)pyrazol-1-yl-kappaN2]pyridine-kappaN)cobalt(II) dinitrate at 290 and 150 K. The title compound, [Co(C(29)H(29)N(5))(2)](NO(3))(2), contains a six-coordinate high-spin Co(II) ion with approximate local D(2d) symmetry.	cobalt(ii) dinitrate	74-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	204-210
12600292-1	2003	BACKGROUND &amp; OBJECTIVE: Some research showed that carcinoembryonic antigen(CEA) related to cell adhesion and cyclooxygenesis 2(COX2) may be related to colorectal carcinogenesis.	Adenosine Monophosphate	12-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-135
12576462-2	2003	To examine the role of inflammatory cells in brain edema formation, we studied the expression cyclooxygenase (COX)-2, a key enzyme in arachidonic acid metabolism, by microglia in the C6 rodent glioma model.	Arachidonic Acid	134-150	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-116
12598417-2	2003	Acetaminophen, an analgesic and antipyretic drug with weak antiinflammatory properties, has been suggested to act as a tissue-selective inhibitor of prostaglandin H synthases (PGHSs) (e.g. COX-1 and COX-2) through its reducing activity, that is influenced by the different cellular levels of peroxides.	Acetaminophen	0-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	199-204
12598417-13	2003	6 In conclusion, therapeutic concentrations of acetaminophen caused an incomplete inhibition of platelet COX-1 and monocyte COX-2 but in the presence of plasma, the drug almost completely suppressed inducible PGE(2) biosynthesis through its inhibitory effects on both COX-2 and inducible PGES.	Acetaminophen	47-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	124-129
12598417-13	2003	6 In conclusion, therapeutic concentrations of acetaminophen caused an incomplete inhibition of platelet COX-1 and monocyte COX-2 but in the presence of plasma, the drug almost completely suppressed inducible PGE(2) biosynthesis through its inhibitory effects on both COX-2 and inducible PGES.	Acetaminophen	47-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	268-273
12708493-5	2003	We confirmed that the selective COX-2 inhibitor, NS-398 suppressed the constitutive production of G-CSF and GM-CSF, and the cell growth in both OKa-C-1 and MI-4 cell lines.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	49-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-37
12576462-5	2003	RESULTS: In contrast to C6 glioma cells, microglia isolated from intracranial C6 tumors produced high levels of PGE(2) through a COX-2-dependent pathway.	Prostaglandins E	112-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-134
12576462-8	2003	CONCLUSIONS: These findings suggest that glioma-infiltrating microglia are a major source of PGE(2) production through the COX-2 pathway and support the use of COX-2 inhibitors as possible alternatives to glucocorticoids in the treatment of peritumoral edema in patients with malignant brain tumors.	Dinoprostone	93-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-128
12749519-3	2003	OBJECTIVE: The objective of this analysis was to estimate the COX-2 specific inhibitor medication costs, in addition to the costs of drugs and physicians" fees, for BP destabilization and clinically significant edema associated with the use of rofecoxib 25 mg QD and celecoxib 200 mg QD in patients with OA and hypertension in a Medicare Choice population (aged &gt; or = 65 years).	rofecoxib	244-253	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
12608557-2	2003	We report the first cases of membranous glomerulopathy and acute interstitial nephritis following treatment with celecoxib (Celebrex), a selective COX-2 inhibitor.	Celecoxib	113-122	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-152
12608557-2	2003	We report the first cases of membranous glomerulopathy and acute interstitial nephritis following treatment with celecoxib (Celebrex), a selective COX-2 inhibitor.	Celecoxib	124-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-152
12530941-3	2003	COX-2 metabolites have been implicated in mediation of renin release, regulation of sodium excretion, and maintenance of renal blood flow.	Sodium	84-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
12749519-10	2003	CONCLUSION: Celecoxib was a less costly treatment option than rofecoxib among OA patients with hypertension aged &gt; or = 65 years, based on our model of the direct costs of COX-2 specific inhibitor therapy combined with those associated with physician monitoring and treatment of edema and BP destabilization.	Celecoxib	12-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	175-180
12490541-7	2003	In a clinical study, we analyzed the effect of a selective COX-2 inhibitor, Rofecoxib, on the migration of monocytes derived from cancer patients.	rofecoxib	76-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-64
12620660-0	2003	Synthesis of heteroaromatic analogues of (2-aryl-1-cyclopentenyl-1-alkylidene)-(arylmethyloxy)amine COX-2 inhibitors: effects on the inhibitory activity of the replacement of the cyclopentene central core with pyrazole, thiophene or isoxazole ring.	(2-aryl-1-cyclopentenyl-1-alkylidene)-(arylmethyloxy)amine	41-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-105
12562317-0	2003	Clinical pharmacology of etoricoxib: a novel selective COX2 inhibitor.	Etoricoxib	25-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-59
12562317-1	2003	The development of COX2 inhibitors with improved biochemical selectivity (such as etoricoxib and valdecoxib) over that of commercially available coxibs has been driven by the potential advantage of safety using higher coxib doses for increased efficacy.	Etoricoxib	82-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-23
12562317-1	2003	The development of COX2 inhibitors with improved biochemical selectivity (such as etoricoxib and valdecoxib) over that of commercially available coxibs has been driven by the potential advantage of safety using higher coxib doses for increased efficacy.	valdecoxib	97-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-23
12562317-4	2003	Etoricoxib has an in vitro COX1/COX2 IC(50) ratio of 344, the highest of any coxib.	Etoricoxib	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-36
12562317-6	2003	The profound inhibition of monocyte COX2 activity at 24 h after dosing, as predicted by a pharmacological half-life of approximately 22 h, supports a once-daily dosing regimen of etoricoxib.	Etoricoxib	179-189	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-40
12620660-1	2003	Several heteroaromatic analogues of (2-aryl-1-cyclopentenyl-1-alkylidene)-(arylmethyloxy)amine COX-2 inhibitors, in which the cyclopentene moiety was replaced by pyrazole, thiophene or isoxazole ring, were synthesized, in order to verify the influence of the different nature of the central core on the COX inhibitory properties of these kinds of molecules.	(2-aryl-1-cyclopentenyl-1-alkylidene)-(arylmethyloxy)amine	36-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-100
12557133-9	2003	Serious lower GI events were 54% lower with the use of the selective COX-2 inhibitor rofecoxib.	rofecoxib	85-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-74
12620660-1	2003	Several heteroaromatic analogues of (2-aryl-1-cyclopentenyl-1-alkylidene)-(arylmethyloxy)amine COX-2 inhibitors, in which the cyclopentene moiety was replaced by pyrazole, thiophene or isoxazole ring, were synthesized, in order to verify the influence of the different nature of the central core on the COX inhibitory properties of these kinds of molecules.	Cyclopentanes	126-138	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-100
12620660-1	2003	Several heteroaromatic analogues of (2-aryl-1-cyclopentenyl-1-alkylidene)-(arylmethyloxy)amine COX-2 inhibitors, in which the cyclopentene moiety was replaced by pyrazole, thiophene or isoxazole ring, were synthesized, in order to verify the influence of the different nature of the central core on the COX inhibitory properties of these kinds of molecules.	pyrazole	162-170	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-100
12620660-1	2003	Several heteroaromatic analogues of (2-aryl-1-cyclopentenyl-1-alkylidene)-(arylmethyloxy)amine COX-2 inhibitors, in which the cyclopentene moiety was replaced by pyrazole, thiophene or isoxazole ring, were synthesized, in order to verify the influence of the different nature of the central core on the COX inhibitory properties of these kinds of molecules.	Thiophenes	172-181	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-100
12620660-1	2003	Several heteroaromatic analogues of (2-aryl-1-cyclopentenyl-1-alkylidene)-(arylmethyloxy)amine COX-2 inhibitors, in which the cyclopentene moiety was replaced by pyrazole, thiophene or isoxazole ring, were synthesized, in order to verify the influence of the different nature of the central core on the COX inhibitory properties of these kinds of molecules.	Isoxazoles	185-194	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-100
12620660-2	2003	Among the compounds tested, only the 3-(p-methylsulfonylphenyl) substituted thiophene derivatives 17 and 22, showed a certain COX-2 inhibitory activity, accompanied by an appreciable COX-2 versus COX-1 selectivity.	3-(p-methylsulfonylphenyl) substituted thiophene	37-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-131
12620660-2	2003	Among the compounds tested, only the 3-(p-methylsulfonylphenyl) substituted thiophene derivatives 17 and 22, showed a certain COX-2 inhibitory activity, accompanied by an appreciable COX-2 versus COX-1 selectivity.	3-(p-methylsulfonylphenyl) substituted thiophene	37-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	183-188
12590029-0	2003	The COX-2 specific inhibitor, valdecoxib, is an effective, opioid-sparing analgesic in patients undergoing total knee arthroplasty.	valdecoxib	30-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
12594587-10	2003	In FHF, the specific COX-2 inhibitor, N-(2-cyclohexyloxy-4-nitrophenyl) methanesulfonamide (1 micro m/l), but not L-NAME, significantly enhanced the maximal effect ( p&lt;0.01) and the sensitivity ( p&lt;0.01) to norepinephrine.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	38-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-26
12594587-10	2003	In FHF, the specific COX-2 inhibitor, N-(2-cyclohexyloxy-4-nitrophenyl) methanesulfonamide (1 micro m/l), but not L-NAME, significantly enhanced the maximal effect ( p&lt;0.01) and the sensitivity ( p&lt;0.01) to norepinephrine.	Norepinephrine	213-227	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-26
12590029-1	2003	This multicenter, randomized, double-blind, placebo-controlled study evaluated the analgesic efficacy and opioid-sparing effects of valdecoxib, a potent COX-2 specific inhibitor, in patients undergoing knee replacement.	valdecoxib	132-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	153-158
12433932-5	2003	These COX-2 inhibitors could also inhibit 12-O-tetradecanoylphorbol-13-acetate-induced cell transformation.	Tetradecanoylphorbol Acetate	42-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	6-11
12527817-3	2003	One of these, triacetylsalicylhydroxamic acid (TriAcSHA) was more effective than aspirin and O-acetylsalicylhydroxamic acid in inactivating both COX-1 and COX-2.	triacetylsalicylhydroxamic acid	14-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	155-160
12527817-3	2003	One of these, triacetylsalicylhydroxamic acid (TriAcSHA) was more effective than aspirin and O-acetylsalicylhydroxamic acid in inactivating both COX-1 and COX-2.	triacetylsalicylhydroxamic acid	47-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	155-160
12527817-3	2003	One of these, triacetylsalicylhydroxamic acid (TriAcSHA) was more effective than aspirin and O-acetylsalicylhydroxamic acid in inactivating both COX-1 and COX-2.	Aspirin	81-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	155-160
12527817-3	2003	One of these, triacetylsalicylhydroxamic acid (TriAcSHA) was more effective than aspirin and O-acetylsalicylhydroxamic acid in inactivating both COX-1 and COX-2.	O-acetylsalicylhydroxamic acid	93-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	155-160
12583353-0	2003	Cardiovascular thrombotic events and COX-2 inhibitors: results in patients with osteoarthritis receiving rofecoxib.	rofecoxib	105-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-42
12468543-0	2003	Leptomycin B, an inhibitor of the nuclear export receptor CRM1, inhibits COX-2 expression.	leptomycin B	0-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-78
12468543-3	2003	Here, we report that leptomycin B (LMB), a specific inhibitor of the nuclear export factor CRM1 potently inhibits the stabilization of COX-2 mRNA in MDA-MB-231 human mammary cancer cells.	leptomycin B	21-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-140
12468543-3	2003	Here, we report that leptomycin B (LMB), a specific inhibitor of the nuclear export factor CRM1 potently inhibits the stabilization of COX-2 mRNA in MDA-MB-231 human mammary cancer cells.	leptomycin B	35-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-140
12468543-5	2003	Subcellular fractionation experiments indicate that LMB inhibited the time-dependent export of COX-2 mRNA into the membrane-bound polysomal compartment at the endoplasmic reticulum.	leptomycin B	52-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-100
12433932-6	2003	UVB significantly increased AP-1 activity in Cox-2(-/-) fibroblasts transfected with an AP-1 luciferase reporter gene, and this increase was blocked by NS-389 or piroxicam.	Piroxicam	162-171	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-50
12433932-7	2003	In JB6, Cox-2(-/-), or wild-type Cox-2(+/+) cells, both NS-398 and piroxicam inhibited UVB-induced phosphorylation of c-Jun NH(2)-terminal kinases, the kinases that activate the AP-1/c-Jun complex.	Piroxicam	67-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	8-13
12433932-7	2003	In JB6, Cox-2(-/-), or wild-type Cox-2(+/+) cells, both NS-398 and piroxicam inhibited UVB-induced phosphorylation of c-Jun NH(2)-terminal kinases, the kinases that activate the AP-1/c-Jun complex.	Piroxicam	67-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-38
12433932-8	2003	Based on our results, we propose that the inhibition of AP-1 activity by COX-2 inhibitors NS-398 or piroxicam may occur by a mechanism that is independent of COX-2.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	90-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-78
12504791-2	2003	According to a popular hypothesis, COX-1 generates "good" prostaglandins for physiological "housekeeping" functions like gastrointestinal (GI) mucosal integrity and regulation of renal blood flow, while COX-2 forms the "bad" prostaglandins responsible for inflammatory symptoms.	Prostaglandins	225-239	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	203-208
12504791-7	2003	The synthesis of endothelial prostacyclin is mainly driven by COX-2, so that the selective COX-2 inhibition may bias vascular prostaglandin synthesis in favour of COX-1-derived thromboxane A(2) in platelets, leading to a prothrombotic outcome.	Epoprostenol	29-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
12504791-7	2003	The synthesis of endothelial prostacyclin is mainly driven by COX-2, so that the selective COX-2 inhibition may bias vascular prostaglandin synthesis in favour of COX-1-derived thromboxane A(2) in platelets, leading to a prothrombotic outcome.	Epoprostenol	29-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-96
12504791-7	2003	The synthesis of endothelial prostacyclin is mainly driven by COX-2, so that the selective COX-2 inhibition may bias vascular prostaglandin synthesis in favour of COX-1-derived thromboxane A(2) in platelets, leading to a prothrombotic outcome.	Prostaglandins	126-139	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-96
12504791-7	2003	The synthesis of endothelial prostacyclin is mainly driven by COX-2, so that the selective COX-2 inhibition may bias vascular prostaglandin synthesis in favour of COX-1-derived thromboxane A(2) in platelets, leading to a prothrombotic outcome.	thromboxane a	177-190	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-96
12504791-8	2003	Moreover, prostaglandins formed by COX-2 appear to have a major role in myocardial protection.	Prostaglandins	10-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40
12517972-2	2003	We show in this study that indomethacin (Indo), flurbiprofen (Flur), and the selective COX-2 inhibitor NS-398 induced COX-2 expression and markedly enhanced IL-1beta-induced COX-2 expression in human airway smooth muscle (HASM) cells.	Indomethacin	27-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-123
12517972-2	2003	We show in this study that indomethacin (Indo), flurbiprofen (Flur), and the selective COX-2 inhibitor NS-398 induced COX-2 expression and markedly enhanced IL-1beta-induced COX-2 expression in human airway smooth muscle (HASM) cells.	Indomethacin	27-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-123
12517972-2	2003	We show in this study that indomethacin (Indo), flurbiprofen (Flur), and the selective COX-2 inhibitor NS-398 induced COX-2 expression and markedly enhanced IL-1beta-induced COX-2 expression in human airway smooth muscle (HASM) cells.	Indomethacin	41-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-123
12517972-2	2003	We show in this study that indomethacin (Indo), flurbiprofen (Flur), and the selective COX-2 inhibitor NS-398 induced COX-2 expression and markedly enhanced IL-1beta-induced COX-2 expression in human airway smooth muscle (HASM) cells.	Indomethacin	41-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-123
12517972-2	2003	We show in this study that indomethacin (Indo), flurbiprofen (Flur), and the selective COX-2 inhibitor NS-398 induced COX-2 expression and markedly enhanced IL-1beta-induced COX-2 expression in human airway smooth muscle (HASM) cells.	Flurbiprofen	48-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-123
12517972-2	2003	We show in this study that indomethacin (Indo), flurbiprofen (Flur), and the selective COX-2 inhibitor NS-398 induced COX-2 expression and markedly enhanced IL-1beta-induced COX-2 expression in human airway smooth muscle (HASM) cells.	Flurbiprofen	48-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-123
12517972-2	2003	We show in this study that indomethacin (Indo), flurbiprofen (Flur), and the selective COX-2 inhibitor NS-398 induced COX-2 expression and markedly enhanced IL-1beta-induced COX-2 expression in human airway smooth muscle (HASM) cells.	Flurbiprofen	62-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-123
12517972-2	2003	We show in this study that indomethacin (Indo), flurbiprofen (Flur), and the selective COX-2 inhibitor NS-398 induced COX-2 expression and markedly enhanced IL-1beta-induced COX-2 expression in human airway smooth muscle (HASM) cells.	Flurbiprofen	62-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-123
12517972-2	2003	We show in this study that indomethacin (Indo), flurbiprofen (Flur), and the selective COX-2 inhibitor NS-398 induced COX-2 expression and markedly enhanced IL-1beta-induced COX-2 expression in human airway smooth muscle (HASM) cells.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	103-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-92
12517972-2	2003	We show in this study that indomethacin (Indo), flurbiprofen (Flur), and the selective COX-2 inhibitor NS-398 induced COX-2 expression and markedly enhanced IL-1beta-induced COX-2 expression in human airway smooth muscle (HASM) cells.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	103-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-123
12517972-2	2003	We show in this study that indomethacin (Indo), flurbiprofen (Flur), and the selective COX-2 inhibitor NS-398 induced COX-2 expression and markedly enhanced IL-1beta-induced COX-2 expression in human airway smooth muscle (HASM) cells.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	103-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-123
12517972-4	2003	Indeed, PGE(2) also induced and enhanced IL-1beta-induced COX-2 expression.	Prostaglandins E	8-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
12543811-6	2003	IL-1beta-mediated stimulation of PGE2 was fully blocked in the presence of a nonselective COX inhibitor (indomethacin) or a selective COX-2 inhibitor (NS-398).	Dinoprostone	33-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-139
12517972-8	2003	Pretreatment with dexamethasone suppressed COX-2 expression, PGE(2) release, and COX activity induced by NS-398, Cig, IL-1beta, alone or in combination.	Dexamethasone	18-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
12543811-6	2003	IL-1beta-mediated stimulation of PGE2 was fully blocked in the presence of a nonselective COX inhibitor (indomethacin) or a selective COX-2 inhibitor (NS-398).	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	151-157	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-139
12543811-8	2003	This modestly greater COX-2 transcription rate could not alone account for the dramatically higher levels of COX-2 mRNA and protein and PGE2 in cancer-associated compared with normal fibroblasts.	Dinoprostone	136-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-27
12445672-2	2003	These cucurbitacins were evaluated for their inhibitory effects on the growth of human colon (HCT-116), breast (MCF-7), lung (NCI-H460), and central nervous system (CNS) (SF-268) cancer cell lines, cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) enzymes and on lipid peroxidation.	Cucurbitacins	6-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	245-250
12543811-9	2003	However, incubation of fibroblasts with PGE2 after IL-1beta stimulation prolonged COX-2 mRNA half-life from approximately 1 to 9 h. Our results strengthen the evidence that fibroblasts and other mesenchymal cells are the source of COX-2 expression in normal and premalignant colorectal tissue.	Dinoprostone	40-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
12543811-9	2003	However, incubation of fibroblasts with PGE2 after IL-1beta stimulation prolonged COX-2 mRNA half-life from approximately 1 to 9 h. Our results strengthen the evidence that fibroblasts and other mesenchymal cells are the source of COX-2 expression in normal and premalignant colorectal tissue.	Dinoprostone	40-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	231-236
12543811-11	2003	We hypothesize that the effects of modestly greater COX-2 transcription in groups II-IV fibroblasts yield corresponding modest increases in PGE2 synthesis whose effects are progressively amplified through robust stabilization of COX-2 mRNA.	Dinoprostone	140-144	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-57
12445672-7	2003	Ibuprofen and naproxen exhibited 59 and 95% COX-1, and 53 and 79% COX-2 inhibitory activities, respectively.	Ibuprofen	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-71
12445672-7	2003	Ibuprofen and naproxen exhibited 59 and 95% COX-1, and 53 and 79% COX-2 inhibitory activities, respectively.	Naproxen	14-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-71
12445672-8	2003	Vioxx showed specific COX-2 inhibition by 71%.	rofecoxib	0-5	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-27
18968885-1	2003	An application to the investigation of dioxygenated Co(II) complex formation in dimethylsulfoxide solution.	Dimethyl Sulfoxide	80-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-57
12513074-1	2003	Synthetic efforts targeting soluble species of Co(II) with the low molecular mass physiological ligand citric acid led to the isolation of the first dinuclear complex [Co(2)(C(6)H(5)O(7))(2)(H(2)O)(4)](2-), at pH approximately 5, in the form of its K+ (1) and Na+ (2) salts.	co(2)	168-173	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-53
12513074-6	2003	The octahedral environment around each Co(II) is complemented by another singly bonded citrate belonging to the adjacent Co(II) unit and two water molecules.	Citric Acid	87-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-45
12513074-6	2003	The octahedral environment around each Co(II) is complemented by another singly bonded citrate belonging to the adjacent Co(II) unit and two water molecules.	Citric Acid	87-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-127
12513074-6	2003	The octahedral environment around each Co(II) is complemented by another singly bonded citrate belonging to the adjacent Co(II) unit and two water molecules.	Water	141-146	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-45
12513074-11	2003	Collectively, this comprehensive study offers significant structural insight into the Co(II)-citrate speciation and the elucidation of the role of Co(II) in biological fluids.	Citric Acid	93-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-91
12513074-11	2003	Collectively, this comprehensive study offers significant structural insight into the Co(II)-citrate speciation and the elucidation of the role of Co(II) in biological fluids.	Citric Acid	93-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-92
12816152-4	2003	The goal of our study was to estimate the frequency of intolerance reactions due to ingestion of the two newly approved selective COX-2 inhibitors, rofecoxib or celecoxib.	rofecoxib	148-157	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	130-135
12816152-4	2003	The goal of our study was to estimate the frequency of intolerance reactions due to ingestion of the two newly approved selective COX-2 inhibitors, rofecoxib or celecoxib.	Celecoxib	161-170	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	130-135
18968885-4	2003	The utility is here applied to the determination, by UV-Vis spectroscopy, of the stability constant for the uptake of molecular dioxygen by the 1:2 complex of Co(II) with N,N"-dimethylethylenediamine (dmen) in the aprotic solvent dimethylsulfoxide (dmso) at 298 K and in a medium adjusted to 0.1 mol dm(-3) with Et(4)NClO(4).	Oxygen	128-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	159-164
18968885-4	2003	The utility is here applied to the determination, by UV-Vis spectroscopy, of the stability constant for the uptake of molecular dioxygen by the 1:2 complex of Co(II) with N,N"-dimethylethylenediamine (dmen) in the aprotic solvent dimethylsulfoxide (dmso) at 298 K and in a medium adjusted to 0.1 mol dm(-3) with Et(4)NClO(4).	dimethylethylenediamine	171-199	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	159-164
18968885-4	2003	The utility is here applied to the determination, by UV-Vis spectroscopy, of the stability constant for the uptake of molecular dioxygen by the 1:2 complex of Co(II) with N,N"-dimethylethylenediamine (dmen) in the aprotic solvent dimethylsulfoxide (dmso) at 298 K and in a medium adjusted to 0.1 mol dm(-3) with Et(4)NClO(4).	dimethylethylenediamine	201-205	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	159-164
18968885-4	2003	The utility is here applied to the determination, by UV-Vis spectroscopy, of the stability constant for the uptake of molecular dioxygen by the 1:2 complex of Co(II) with N,N"-dimethylethylenediamine (dmen) in the aprotic solvent dimethylsulfoxide (dmso) at 298 K and in a medium adjusted to 0.1 mol dm(-3) with Et(4)NClO(4).	Dimethyl Sulfoxide	230-247	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	159-164
18968885-4	2003	The utility is here applied to the determination, by UV-Vis spectroscopy, of the stability constant for the uptake of molecular dioxygen by the 1:2 complex of Co(II) with N,N"-dimethylethylenediamine (dmen) in the aprotic solvent dimethylsulfoxide (dmso) at 298 K and in a medium adjusted to 0.1 mol dm(-3) with Et(4)NClO(4).	Dimethyl Sulfoxide	249-253	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	159-164
18968885-4	2003	The utility is here applied to the determination, by UV-Vis spectroscopy, of the stability constant for the uptake of molecular dioxygen by the 1:2 complex of Co(II) with N,N"-dimethylethylenediamine (dmen) in the aprotic solvent dimethylsulfoxide (dmso) at 298 K and in a medium adjusted to 0.1 mol dm(-3) with Et(4)NClO(4).	dm	201-203	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	159-164
18968885-4	2003	The utility is here applied to the determination, by UV-Vis spectroscopy, of the stability constant for the uptake of molecular dioxygen by the 1:2 complex of Co(II) with N,N"-dimethylethylenediamine (dmen) in the aprotic solvent dimethylsulfoxide (dmso) at 298 K and in a medium adjusted to 0.1 mol dm(-3) with Et(4)NClO(4).	et(4)	312-317	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	159-164
15000126-6	2003	The response of bone cells in culture to fluid flow includes prostaglandin (PG) synthesis and expression of prostaglandin G/H synthase inducible cyclooxygenase (COX-2).	Prostaglandins	108-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	161-166
12848367-1	2003	Mixed ligand Co(II) and Ni(II) complexes have been synthesized by using 8-hydroxyquinoline as primary ligand and N- and/or O- donor ligands such as tartaric acid/phenylalanine as secondary ligands.	Oxyquinoline	72-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-30
12848367-1	2003	Mixed ligand Co(II) and Ni(II) complexes have been synthesized by using 8-hydroxyquinoline as primary ligand and N- and/or O- donor ligands such as tartaric acid/phenylalanine as secondary ligands.	tartaric acid	148-161	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-30
12848367-1	2003	Mixed ligand Co(II) and Ni(II) complexes have been synthesized by using 8-hydroxyquinoline as primary ligand and N- and/or O- donor ligands such as tartaric acid/phenylalanine as secondary ligands.	Phenylalanine	162-175	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-30
12751755-0	2003	Induction of COX-2 expression by the endocannabinoid derivative R(+)-methanandamide.	Endocannabinoids	37-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
12751755-0	2003	Induction of COX-2 expression by the endocannabinoid derivative R(+)-methanandamide.	methanandamide	64-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
12574066-1	2003	Cyclooxygenases-1 and -2 (COX-1 and COX-2, also known as prostaglandin H2 synthases-1 and -2) catalyze the committed step in prostaglandin synthesis.	Prostaglandins	57-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-41
12522725-25	2003	It consists of the simultaneous administration of low-dose ketamine, co-administration of an alpha 2-agonist, and the administration of a selective COX-2 inhibitor (refecoxib, parecoxib) respectively.	rofecoxib	165-174	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	148-153
14669788-2	2003	In this study, effects of the COX-2 inhibitor JTE-522 on cell viability, invasion, and invasion-related cellular properties were determined.	4-(4-cyclohexyl-2-methyloxazol-5-yl)-2-fluorobenzenesulfonamide	46-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-35
12716445-3	2003	Large outcome studies have shown that patients with OA and RA not taking low-dose aspirin have fewer symptomatic and complicated upper GI events when treated with COX-2 selective inhibitors than with nonselective NSAIDs.	Aspirin	82-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	163-168
12614262-1	2003	OBJECTIVE: To examine cyclooxygenase (COX)-2 expression (a key enzyme in the synthesis of prostaglandins, and involved in carcinogenesis of human epithelial tumours) in human transitional cell carcinomas (TCCs) of the renal pelvis and ureter, and to determine whether COX-2 expression correlates with the clinicopathological characteristics of the disease.	Prostaglandins	90-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-44
12534640-10	2003	Marked diclofenac mediated inhibition of COX-1- and COX-2 activity was detected in all individuals independent of CYP2C9 genotype.	Diclofenac	7-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-57
12629931-1	2003	The discovery of the isoenzymes cyclooxygenase-(COX-) 1 and COX-2 led to the development of newer nonsteroidal anti-inflammatory drugs (NSAIDs) designed to block COX-2, such as rofecoxib, celecoxib, and valdecoxib.	rofecoxib	177-186	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-65
12629931-1	2003	The discovery of the isoenzymes cyclooxygenase-(COX-) 1 and COX-2 led to the development of newer nonsteroidal anti-inflammatory drugs (NSAIDs) designed to block COX-2, such as rofecoxib, celecoxib, and valdecoxib.	rofecoxib	177-186	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	162-167
12629931-1	2003	The discovery of the isoenzymes cyclooxygenase-(COX-) 1 and COX-2 led to the development of newer nonsteroidal anti-inflammatory drugs (NSAIDs) designed to block COX-2, such as rofecoxib, celecoxib, and valdecoxib.	Celecoxib	188-197	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-65
12629931-1	2003	The discovery of the isoenzymes cyclooxygenase-(COX-) 1 and COX-2 led to the development of newer nonsteroidal anti-inflammatory drugs (NSAIDs) designed to block COX-2, such as rofecoxib, celecoxib, and valdecoxib.	Celecoxib	188-197	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	162-167
12629931-1	2003	The discovery of the isoenzymes cyclooxygenase-(COX-) 1 and COX-2 led to the development of newer nonsteroidal anti-inflammatory drugs (NSAIDs) designed to block COX-2, such as rofecoxib, celecoxib, and valdecoxib.	valdecoxib	203-213	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-65
12629931-1	2003	The discovery of the isoenzymes cyclooxygenase-(COX-) 1 and COX-2 led to the development of newer nonsteroidal anti-inflammatory drugs (NSAIDs) designed to block COX-2, such as rofecoxib, celecoxib, and valdecoxib.	valdecoxib	203-213	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	162-167
12629931-6	2003	Recent studies suggest that COX-2-derived prostaglandins may play an important role in tumor viability, growth, and control of metastasis.	Prostaglandins	42-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
14669788-3	2003	JTE-522 (10 microM) induced a 75-90% reduction in invasion, compared to cells treated with a vehicle only, in the COX-2-expressing cells.	4-(4-cyclohexyl-2-methyloxazol-5-yl)-2-fluorobenzenesulfonamide	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-119
12743436-1	2003	BACKGROUND: Cyclooxygenase (COX)-2 is the rate-limiting enzyme in prostaglandin synthesis, and plays an important role in tumor enlargement.	Prostaglandins	66-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-34
12603175-1	2003	OBJECTIVE: To analyse the influence of age and cytochrome P450 (CYP) 2C9 genotype on the steady-state disposition of the standard NSAID diclofenac and the new COX-2 selective inhibitor celecoxib, both of which are metabolised by the polymorphically expressed CYP2C9.	Celecoxib	185-194	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	159-164
14529405-9	2003	Data from different animal models of inflammatory bowel disease suggest that inhibition of both COX-1 and COX-2 derived prostaglandins affects the severity of the mucosal inflammation.	Prostaglandins	120-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-111
14583067-5	2003	More recently, selective COX-2 inhibitors ("coxibs") were designed to inhibit the production of COX-2-dependent inflammatory prostanoids and to leave intact the cytoprotective COX-1 products.	Prostaglandins	125-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-30
14506909-2	2003	COX-1 is responsible for homeostatic functions, whereas COX-2 is inducible and responsible for the inflammatory effects of prostaglandins.	Prostaglandins	123-137	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-61
14506909-3	2003	Nimesulide, a selective inhibitor of COX-2, has been shown to relieve pain rapidly in arthritis.	nimesulide	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-42
14583067-5	2003	More recently, selective COX-2 inhibitors ("coxibs") were designed to inhibit the production of COX-2-dependent inflammatory prostanoids and to leave intact the cytoprotective COX-1 products.	Prostaglandins	125-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-101
14506909-9	2003	COX-1 and COX-2 activities in whole blood were estimated by serum thromboxane B2 (TxB2) and endotoxin-induced PGE2 concentrations respectively.	Thromboxane B2	66-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
14506909-18	2003	CONCLUSIONS: Nimesulide, a COX-2 selective inhibitor, has a rapid onset of action in the blood compartment, with early inhibition of PGE2 generation, an index of COX-2 activity.	nimesulide	13-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-32
14583067-8	2003	These concerns were driven initially by the concept that inhibition of COX-2-derived endothelial PGI2 without concomitant inhibition of platelet thromboxane A2 would result in increased cardiovascular risk.	Epoprostenol	97-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-76
14506909-18	2003	CONCLUSIONS: Nimesulide, a COX-2 selective inhibitor, has a rapid onset of action in the blood compartment, with early inhibition of PGE2 generation, an index of COX-2 activity.	nimesulide	13-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	162-167
14583067-10	2003	Further elucidation of the relative roles of COX-1- and COX-2-generated prostanoids has enabled a greater understanding of the biology of these pathways.	Prostaglandins	72-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-61
12487621-1	2003	The discovery of two cyclooxygenase (COX)-isoenzymes, a constitutive COX-1, serving homeostatic prostanoid synthesis, and an inducible COX-2, responsible for proinflammatory prostanoid production, led to the development of new non-steroidal anti-inflammatory drugs (NSAIDs), the selective COX-2 inhibitors, promising minimal NSAID-typical toxicity with full anti-inflammatory efficacy.	Prostaglandins	174-184	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-140
14758788-7	2003	Because coxibs do not inhibit platelet aggregation, if prophylaxis against thromboembolic disease is required in patients being treated with a selective COX-2 inhibitor, low-dose aspirin should be used in conjunction with the coxib.	Aspirin	179-186	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	153-158
12487621-9	2003	Parecoxib as a parenteral, highly selective COX-2 inhibitor has the potential to become the NSAID of choice for treatment of postoperative pain.	parecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-49
12487621-14	2003	However, trials with the new COX-2 inhibitors offer the chance to address these open questions of highly selective COX-2 inhibition; that is, thrombogenic risk, sodium and water retention, and interference with tissue repair, in particular, healing of mucosal damage.	Sodium	161-167	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34
12487621-14	2003	However, trials with the new COX-2 inhibitors offer the chance to address these open questions of highly selective COX-2 inhibition; that is, thrombogenic risk, sodium and water retention, and interference with tissue repair, in particular, healing of mucosal damage.	Water	172-177	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34
12605743-1	2003	BACKGROUND: Non-steroidal anti-inflammatory drugs (NSAIDs), used for the treatment of osteoarthritis, can produce serious gastrointestinal (GI) adverse reactions.Celecoxib, a specific COX-2 inhibitor, has a proven efficacy equivalent to that of traditional NSAIDs with an improved tolerance and safety profile.	Celecoxib	162-171	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	184-189
12542292-4	2003	The order of the lability of the metal complexes, Co(II) &gt; Ni(II) &gt; Cu(II) &lt; Zn(II), follows the reverse order of the ligand field stabilization energy with the exception of Cu(II); the behavior of Cu(II) is also due to the Jahn-Teller effect, which shortens the equatorial bonds and lengthens the axial bonds of a tetragonally distorted Cu(II)-L6 complex.	Metals	33-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-56
12542292-4	2003	The order of the lability of the metal complexes, Co(II) &gt; Ni(II) &gt; Cu(II) &lt; Zn(II), follows the reverse order of the ligand field stabilization energy with the exception of Cu(II); the behavior of Cu(II) is also due to the Jahn-Teller effect, which shortens the equatorial bonds and lengthens the axial bonds of a tetragonally distorted Cu(II)-L6 complex.	Zinc	86-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-56
12542292-4	2003	The order of the lability of the metal complexes, Co(II) &gt; Ni(II) &gt; Cu(II) &lt; Zn(II), follows the reverse order of the ligand field stabilization energy with the exception of Cu(II); the behavior of Cu(II) is also due to the Jahn-Teller effect, which shortens the equatorial bonds and lengthens the axial bonds of a tetragonally distorted Cu(II)-L6 complex.	cu(ii)	74-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-56
12608645-7	2003	Use of selective (NS-398) and non-selective (ibuprofen) COX-2 inhibitors effectively inhibited prostanoid synthesis triggered by CD40 ligation.	Ibuprofen	45-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-61
12608645-7	2003	Use of selective (NS-398) and non-selective (ibuprofen) COX-2 inhibitors effectively inhibited prostanoid synthesis triggered by CD40 ligation.	Prostaglandins	95-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-61
12538086-0	2003	COX-2 inhibition potentiates the antiproteinuric effect of enalapril in uninephrectomized SHR.	Enalapril	59-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
15035793-1	2003	Paracetamol and salicylate are weak inhibitors of both isolated cyclooxygenase-1 (COX-1) and COX-2 but are potent inhibitors of prostaglandin (PG) synthesis in intact cells if low concentrations of arachidonic acid are available.	Acetaminophen	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-98
15035793-1	2003	Paracetamol and salicylate are weak inhibitors of both isolated cyclooxygenase-1 (COX-1) and COX-2 but are potent inhibitors of prostaglandin (PG) synthesis in intact cells if low concentrations of arachidonic acid are available.	Salicylates	16-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-98
15035793-3	2003	At low concentrations of arachidonic acid, COX-2 is the major isoenzyme involved in PG synthesis when both COX-1 and COX-2 are present in cells.	Arachidonic Acid	25-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
15035793-3	2003	At low concentrations of arachidonic acid, COX-2 is the major isoenzyme involved in PG synthesis when both COX-1 and COX-2 are present in cells.	Arachidonic Acid	25-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-122
15035793-3	2003	At low concentrations of arachidonic acid, COX-2 is the major isoenzyme involved in PG synthesis when both COX-1 and COX-2 are present in cells.	Prostaglandins	84-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
15035793-3	2003	At low concentrations of arachidonic acid, COX-2 is the major isoenzyme involved in PG synthesis when both COX-1 and COX-2 are present in cells.	Prostaglandins	84-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-122
15035793-4	2003	Therefore, paracetamol and salicylate may selectively inhibit PG synthesis involving COX-2 because the lower flux through this pathway produces lesser levels of the hydroperoxide, PGG(2), than the pathway involving COX-1.	Acetaminophen	11-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-90
15035793-4	2003	Therefore, paracetamol and salicylate may selectively inhibit PG synthesis involving COX-2 because the lower flux through this pathway produces lesser levels of the hydroperoxide, PGG(2), than the pathway involving COX-1.	Salicylates	27-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-90
15035793-4	2003	Therefore, paracetamol and salicylate may selectively inhibit PG synthesis involving COX-2 because the lower flux through this pathway produces lesser levels of the hydroperoxide, PGG(2), than the pathway involving COX-1.	Prostaglandins	62-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-90
15035793-4	2003	Therefore, paracetamol and salicylate may selectively inhibit PG synthesis involving COX-2 because the lower flux through this pathway produces lesser levels of the hydroperoxide, PGG(2), than the pathway involving COX-1.	Hydrogen Peroxide	165-178	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-90
15035793-4	2003	Therefore, paracetamol and salicylate may selectively inhibit PG synthesis involving COX-2 because the lower flux through this pathway produces lesser levels of the hydroperoxide, PGG(2), than the pathway involving COX-1.	Prostaglandins G	180-183	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-90
15035793-5	2003	Apart from the lack of anti-inflammatory effect of paracetamol in rheumatoid arthritis, the clinical effects of paracetamol and salicylate are very similar and resemble those of the selective COX-2 inhibitors.	Salicylates	128-138	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	192-197
12861847-0	2003	Celecoxib, a highly selective COX-2 inhibitor, is safe in aspirin-induced asthma patients.	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-35
12861847-3	2003	The discoveries that cyclooxygenase COX-2 is an inducible form of COX involved in inflammation and COX-1 is the major isoform responsible for the production of prostaglandins have provided a reasonable basis for the development of specific COX-2 inhibitors as a new class of anti-inflammatory agents.	Prostaglandins	160-174	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-41
12861847-3	2003	The discoveries that cyclooxygenase COX-2 is an inducible form of COX involved in inflammation and COX-1 is the major isoform responsible for the production of prostaglandins have provided a reasonable basis for the development of specific COX-2 inhibitors as a new class of anti-inflammatory agents.	Prostaglandins	160-174	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	240-245
12861847-4	2003	OBJECTIVE: The purpose of this study is to demonstrate that celecoxib, a specific inhibitor of COX-2, does not cause asthmatic attacks in patients with aspirin and/or other nonsteroidal anti-inflammatory drug-induced asthma.	Celecoxib	60-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-100
12593597-1	2003	BACKGROUND: The purpose of the present study was to evaluate the effect of a relatively selective cyclooxygenase (COX)-2 inhibitor (nimesulide) and non-selective COX-1/COX-2 inhibitor (naproxen) used as an adjunct to non-surgical (scaling and root planing [SRP]) periodontal therapy in chronic periodontitis patients on the gingival tissue (GT) levels of prostaglandin (PG)E2 and PGF2alpha.	nimesulide	132-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-120
12593597-13	2003	CONCLUSIONS: Nimesulides, relatively selective COX-2 inhibitors, may have additional inhibitory effects on GT PGF2alpha levels in the first week following non-surgical periodontal treatment.	nimesulide	13-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
12499088-2	2003	Cyclooxygenase (COX)-2 is an enzyme which catalyses the conversion of arachidonic acid to prostagladins and thromboxane.	Arachidonic Acid	70-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-22
12499088-2	2003	Cyclooxygenase (COX)-2 is an enzyme which catalyses the conversion of arachidonic acid to prostagladins and thromboxane.	prostagladins	90-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-22
12499088-2	2003	Cyclooxygenase (COX)-2 is an enzyme which catalyses the conversion of arachidonic acid to prostagladins and thromboxane.	Thromboxanes	108-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-22
12899243-1	2003	An analysis based upon structure-activity relationships (SAR) of the COX-2-inhibiting properties of flavonoids, a group of potential cancer chemopreventative agents, reveals that there is a dual structural basis for these activities.	Flavonoids	100-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-74
12538084-13	2003	Immunohistochemistry in all patients irrespective of Hp status demonstrated expression of COX-2.Lower concentration of constitutive expression of COX-2 was detected in human gastric mucosa by immunohistochemistry, however, H. pylori infection failed to induce COX-2 protein.	histidylproline	53-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	146-151
12538084-13	2003	Immunohistochemistry in all patients irrespective of Hp status demonstrated expression of COX-2.Lower concentration of constitutive expression of COX-2 was detected in human gastric mucosa by immunohistochemistry, however, H. pylori infection failed to induce COX-2 protein.	histidylproline	53-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	146-151
12795055-3	2003	COX-2 appears to: (a) play a key role in the release and activity of proangiogenic proteins; (b) result in the production of eicosanoid products TXA2, PGI2, PGE2 that directly stimulate endothelial cell migration and angiogenesis in vivo, and (c) result in enhanced tumor cell, and possibly, vascular endothelial cell survival by upregulation of the antiapoptotic proteins Bcl-2 and/or activation of PI3K-Akt.	Eicosanoids	125-135	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
12795055-3	2003	COX-2 appears to: (a) play a key role in the release and activity of proangiogenic proteins; (b) result in the production of eicosanoid products TXA2, PGI2, PGE2 that directly stimulate endothelial cell migration and angiogenesis in vivo, and (c) result in enhanced tumor cell, and possibly, vascular endothelial cell survival by upregulation of the antiapoptotic proteins Bcl-2 and/or activation of PI3K-Akt.	Epoprostenol	151-155	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
12795055-3	2003	COX-2 appears to: (a) play a key role in the release and activity of proangiogenic proteins; (b) result in the production of eicosanoid products TXA2, PGI2, PGE2 that directly stimulate endothelial cell migration and angiogenesis in vivo, and (c) result in enhanced tumor cell, and possibly, vascular endothelial cell survival by upregulation of the antiapoptotic proteins Bcl-2 and/or activation of PI3K-Akt.	Dinoprostone	157-161	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
12795056-3	2003	In our recent findings we observed that the antagonists of angiogenesis also inhibited the endogenous as well as phorbol-ester-mediated induction of COX-2 expression in human lung cancer cell lines and that in the xenograft model a combination of angiogenic antagonists and radiation significantly delayed tumor growth [ASCO 2002, Vol.	Phorbol Esters	113-126	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	149-154
14569887-1	2003	The biosynthesis of prostaglandins proceeds in the presence of fatty acid cycloxygenases (COX-1, COX-2).	Prostaglandins	20-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
14569887-2	2003	COX-1 is responsible for the synthesis of prostaglandins indispensable for normal homeostasis, while COX-2 regulates local expression of pro-inflammatory prostaglandins.	Prostaglandins	154-168	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-106
14569887-3	2003	Paracetamol is a selective inhibitor of COX-2 thus having an analgesic and antipyretic potential.	Acetaminophen	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
12549993-10	2003	A pilot study was carried out in 120 patients with acute coronary syndrome without ST-segment elevation in which 60 patients were treated with meloxicam, a preferential COX-2 inhibitor.	Meloxicam	143-152	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	169-174
12465804-1	2003	Adsorption of Co(II) ions from aqueous sepiolite suspensions has been systematically investigated as a function of several variables including activation conditions, solid to liquid ratio, pH and temperature.	magnesium trisilicate	39-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-20
12465804-4	2003	Also, for the first time a plausible correlation between the released Mg(II) ions from sepiolite matrix and those adsorbed Co(II) ions is made.	mg(ii)	70-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-129
12465804-7	2003	The thermodynamic data indicate that Co(II) adsorption onto sepiolite is entropically driven and characterized by physical adsorption.	magnesium trisilicate	60-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-43
12705064-4	2003	Because of their better gastrointestinal risk profile, the newly developed selective COX-2 inhibitors celecoxib and rofecoxib are discussed as cost-effective alternatives to common NSAIDs.	Celecoxib	102-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-90
12705064-4	2003	Because of their better gastrointestinal risk profile, the newly developed selective COX-2 inhibitors celecoxib and rofecoxib are discussed as cost-effective alternatives to common NSAIDs.	rofecoxib	116-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-90
12401798-3	2002	Cyclooxygenase (COX)-2, an inducible enzyme that catalyzes the formation of prostaglandins (PGs) from arachidonic acid, is also induced by hypoxia.	Prostaglandins	76-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-22
12401798-3	2002	Cyclooxygenase (COX)-2, an inducible enzyme that catalyzes the formation of prostaglandins (PGs) from arachidonic acid, is also induced by hypoxia.	Prostaglandins	92-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-22
12401798-3	2002	Cyclooxygenase (COX)-2, an inducible enzyme that catalyzes the formation of prostaglandins (PGs) from arachidonic acid, is also induced by hypoxia.	Arachidonic Acid	102-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-22
12401798-10	2002	Two selective COX-2 inhibitors, meloxicam and NS398, decreased HIF-1alpha levels and nuclear localization, under both normoxic and hypoxic conditions.	Meloxicam	32-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
12401798-10	2002	Two selective COX-2 inhibitors, meloxicam and NS398, decreased HIF-1alpha levels and nuclear localization, under both normoxic and hypoxic conditions.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	46-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
12401798-11	2002	Of several prostaglandins tested, only PGE(2) reversed the effects of a COX-2 inhibitor in hypoxic cells.	Prostaglandins	11-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
12401798-11	2002	Of several prostaglandins tested, only PGE(2) reversed the effects of a COX-2 inhibitor in hypoxic cells.	Prostaglandins E	39-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
12401798-13	2002	These data demonstrate that PGE(2) production via COX-2-catalyzed pathway plays a critical role in HIF-1alpha regulation by hypoxia and imply that COX-2 inhibitors can prevent hypoxic induction of HIF-mediated gene transcription in cancer cells.	Dinoprostone	28-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-55
12401798-13	2002	These data demonstrate that PGE(2) production via COX-2-catalyzed pathway plays a critical role in HIF-1alpha regulation by hypoxia and imply that COX-2 inhibitors can prevent hypoxic induction of HIF-mediated gene transcription in cancer cells.	Dinoprostone	28-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-152
12536789-1	2002	CoII[N(CN)2]2(H2BiIm)2, 1, and [CoII[N(CN)2](H2BiIm)2]Cl, 2 (H2BiIm = 2,2"-biimidazole) have been structurally, spectroscopically, and magnetically characterized with both containing dicyanamides bound in unprecedented manners; namely, solely via the amide nitrogen for 1, and via an imide N forming 1-D helical chains for 2.	2,2'-biimidazole	14-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-4
12536789-1	2002	CoII[N(CN)2]2(H2BiIm)2, 1, and [CoII[N(CN)2](H2BiIm)2]Cl, 2 (H2BiIm = 2,2"-biimidazole) have been structurally, spectroscopically, and magnetically characterized with both containing dicyanamides bound in unprecedented manners; namely, solely via the amide nitrogen for 1, and via an imide N forming 1-D helical chains for 2.	2,2'-biimidazole	70-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-4
12536789-1	2002	CoII[N(CN)2]2(H2BiIm)2, 1, and [CoII[N(CN)2](H2BiIm)2]Cl, 2 (H2BiIm = 2,2"-biimidazole) have been structurally, spectroscopically, and magnetically characterized with both containing dicyanamides bound in unprecedented manners; namely, solely via the amide nitrogen for 1, and via an imide N forming 1-D helical chains for 2.	dicyanamides	183-195	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-4
12536789-1	2002	CoII[N(CN)2]2(H2BiIm)2, 1, and [CoII[N(CN)2](H2BiIm)2]Cl, 2 (H2BiIm = 2,2"-biimidazole) have been structurally, spectroscopically, and magnetically characterized with both containing dicyanamides bound in unprecedented manners; namely, solely via the amide nitrogen for 1, and via an imide N forming 1-D helical chains for 2.	Amides	189-194	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-4
12536789-1	2002	CoII[N(CN)2]2(H2BiIm)2, 1, and [CoII[N(CN)2](H2BiIm)2]Cl, 2 (H2BiIm = 2,2"-biimidazole) have been structurally, spectroscopically, and magnetically characterized with both containing dicyanamides bound in unprecedented manners; namely, solely via the amide nitrogen for 1, and via an imide N forming 1-D helical chains for 2.	Nitrogen	257-265	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-4
12693052-2	2002	The ferromagnetic Co3O14 cluster core consists of three octahedrally oxo-coordinated CoII ions.	co3o14	18-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-89
12693052-3	2002	According to the single-ion anisotropy and spin-orbit coupling of the octahedral CoII ions, the appropriate exchange Hamiltonian to describe the ground-state properties of the Co3 spin cluster is anisotropic and is expressed as H = -2 sigma a = x,y,z (Ja12 S1a S2a + Ja23 S2a S3a), where Ja are the components of the exchange interactions between the CoII ions.	co3	176-179	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-85
12693052-3	2002	According to the single-ion anisotropy and spin-orbit coupling of the octahedral CoII ions, the appropriate exchange Hamiltonian to describe the ground-state properties of the Co3 spin cluster is anisotropic and is expressed as H = -2 sigma a = x,y,z (Ja12 S1a S2a + Ja23 S2a S3a), where Ja are the components of the exchange interactions between the CoII ions.	co3	176-179	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	351-355
12499282-2	2002	We observed that fetal bovine serum antagonizes growth inhibition and G(1) arrest induced by two COX-2 inhibitors (NS-398 and celecoxib) on BxPC-3 pancreatic cancer cells.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	115-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
12499282-2	2002	We observed that fetal bovine serum antagonizes growth inhibition and G(1) arrest induced by two COX-2 inhibitors (NS-398 and celecoxib) on BxPC-3 pancreatic cancer cells.	Celecoxib	126-135	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
12499282-7	2002	Similar results were observed when another COX-2 inhibitor (50 micro M NS-398) was used.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	71-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
12456256-0	2002	Aspirin use may change cost-effectiveness of COX-2 inhibitors.	Aspirin	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-50
12465986-7	2002	This result clearly indicates that the inversion proceeds in the three steps; (i) the Co-C bond was homolytically cleaved by photoirradiation and the 1,2-bis(ethoxycarbonyl)ethyl radical and Co(II) were produced, (ii) the radical rotated by 180 degrees directing the C-D bond to the cobalt atom and the opposite plane of the radical faced to the cobalt atom, and (iii) the radical made a bond with Co(II).	Cobalt	86-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	191-197
12465986-7	2002	This result clearly indicates that the inversion proceeds in the three steps; (i) the Co-C bond was homolytically cleaved by photoirradiation and the 1,2-bis(ethoxycarbonyl)ethyl radical and Co(II) were produced, (ii) the radical rotated by 180 degrees directing the C-D bond to the cobalt atom and the opposite plane of the radical faced to the cobalt atom, and (iii) the radical made a bond with Co(II).	Cobalt	86-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	398-404
12465986-7	2002	This result clearly indicates that the inversion proceeds in the three steps; (i) the Co-C bond was homolytically cleaved by photoirradiation and the 1,2-bis(ethoxycarbonyl)ethyl radical and Co(II) were produced, (ii) the radical rotated by 180 degrees directing the C-D bond to the cobalt atom and the opposite plane of the radical faced to the cobalt atom, and (iii) the radical made a bond with Co(II).	1,2-Bis(ethoxycarbonyl)ethyl radical	150-186	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	398-404
12465986-7	2002	This result clearly indicates that the inversion proceeds in the three steps; (i) the Co-C bond was homolytically cleaved by photoirradiation and the 1,2-bis(ethoxycarbonyl)ethyl radical and Co(II) were produced, (ii) the radical rotated by 180 degrees directing the C-D bond to the cobalt atom and the opposite plane of the radical faced to the cobalt atom, and (iii) the radical made a bond with Co(II).	Cobalt	283-289	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	191-197
12465986-7	2002	This result clearly indicates that the inversion proceeds in the three steps; (i) the Co-C bond was homolytically cleaved by photoirradiation and the 1,2-bis(ethoxycarbonyl)ethyl radical and Co(II) were produced, (ii) the radical rotated by 180 degrees directing the C-D bond to the cobalt atom and the opposite plane of the radical faced to the cobalt atom, and (iii) the radical made a bond with Co(II).	Cobalt	346-352	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	191-197
12561315-0	2002	Dinuclear CoII/GdIII and CoIII/GdIII complexes derived from hexadentate Schiff bases: synthesis, structure, and magnetic properties.	Schiff Bases	72-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-14
12553505-1	2002	We performed a randomized, prospective study on the prophylaxis of heterotopic ossification (HO) after total hip arthroplasty (THR), comparing indomethacin and the selective COX-2 inhibitor meloxicam.	Meloxicam	190-199	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	174-179
12512737-4	2002	Similarly, the use of nonaspirin nonsteroidal antiinflammatory drugs (NSAIDs), including cyclooxygenase (COX)-2 inhibitors, has also been shown to increase the risk of GI effects, and the concomitant use of aspirin and nonaspirin NSAIDs can significantly increase the risk of GI ulceration and bleeding.	Aspirin	25-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-111
12444028-8	2002	Hypoxic inhibition of proliferation was attenuated by incubation with indomethacin (10 micro M), or the COX-2 antagonist, NS398 (10 micro M), but not by the COX-1 antagonist, valeryl salicylate (0.5 mM).	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	122-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
12429575-8	2002	COX-2 activity was measured by the formation of prostaglandin E(2) (PGE(2)) in blood stimulated with lipopolysaccharide (LPS) for 18 h. 3.	Dinoprostone	48-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
12429575-8	2002	COX-2 activity was measured by the formation of prostaglandin E(2) (PGE(2)) in blood stimulated with lipopolysaccharide (LPS) for 18 h. 3.	Dinoprostone	68-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
12429575-11	2002	Indomethacin, nimesulide and the COX-2 selective inhibitor DFP [5,5-dimethyl-3-(2-isopropoxy)-4-(4-methanesulfonylphenyl)-2(5H)-furanone] inhibited COX-2 activity.	Isoflurophate	59-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-38
12429575-11	2002	Indomethacin, nimesulide and the COX-2 selective inhibitor DFP [5,5-dimethyl-3-(2-isopropoxy)-4-(4-methanesulfonylphenyl)-2(5H)-furanone] inhibited COX-2 activity.	5,5-dimethyl-3-(2-isopropoxy)-4-(4-methanesulfonylphenyl)-2(5h)-furanone	64-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-38
12429575-11	2002	Indomethacin, nimesulide and the COX-2 selective inhibitor DFP [5,5-dimethyl-3-(2-isopropoxy)-4-(4-methanesulfonylphenyl)-2(5H)-furanone] inhibited COX-2 activity.	5,5-dimethyl-3-(2-isopropoxy)-4-(4-methanesulfonylphenyl)-2(5h)-furanone	64-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	148-153
12660020-1	2002	A series of 6,7-diaryl-2,3-1H-dihydropyrrolizines was prepared as COX-1/COX-2 and 5-LOX inhibitors.	6,7-diaryl-2,3-1h-dihydropyrrolizines	12-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-83
12660020-4	2002	The balance between COX-1/COX-2 and 5-LOX inhibition can be shifted by modifying the substitution pattern of the phenyl moiety at the 6- and 7-position of the pyrrolizine nucleus.	6,7-diphenyl-2,3-dihydro-1H-pyrrolizine	159-170	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-37
12512699-1	2002	Prostaglandin endoperoxide H2 (PGH2) is generated from arachidonic acid by either constitutive (COX-1) or inducible (COX-2) cyclooxygenases.	prostaglandin endoperoxide h2	0-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-122
12512699-1	2002	Prostaglandin endoperoxide H2 (PGH2) is generated from arachidonic acid by either constitutive (COX-1) or inducible (COX-2) cyclooxygenases.	Prostaglandin H2	31-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-122
12512699-1	2002	Prostaglandin endoperoxide H2 (PGH2) is generated from arachidonic acid by either constitutive (COX-1) or inducible (COX-2) cyclooxygenases.	Arachidonic Acid	55-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-122
12512699-11	2002	It means that IL-1beta-triggered-PGE2 biosynthesis in endothelial cells is probably regulated by induction of both COX-2 and PGE-S.	Dinoprostone	33-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-120
12512699-12	2002	This is way we hypothesise the existence of at least two distinct pools of COX-2: the first selectively coupled to PGE-S and the second one that is coupled to PGI-S yielding the main endothelial product--PGI2.	Epoprostenol	204-208	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
12468638-4	2002	The aims of this study were to investigate the effect of seminal plasma and PGE2 on the expression of COX-2 and expression and signalling of the PGE2 receptor subtypes (EP1-EP4) in HeLa (cervical adenocarcinoma) cells.	Dinoprostone	76-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-107
12468638-5	2002	Treatment of HeLa cells with seminal plasma or PGE2 resulted in up-regulation of COX-2 expression (P &lt; 0.05).	Dinoprostone	47-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-86
12468643-6	2002	Treatment with interleukin-1beta, tumour necrosis factor-alpha or PGE2 caused a significant increase in COX-2 (P &lt; 0.05) but not COX-1 expression in peritoneal macrophages isolated from disease-free women.	Dinoprostone	66-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
12468643-9	2002	Elevated expression of both COX-1 and COX-2 in peritoneal macrophages may contribute to the increased peritoneal fluid PGE2 concentrations and may thus play an important role in the development of endometriosis.	Dinoprostone	119-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-43
12510364-4	2002	Various clinical studies have confirmed that the efficacy of COX-2 inhibitors for RA is similar to that of conventional NSAIDs, but they cause fewer severe gastrointestinal disorders.	Radium	82-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-66
12528468-8	2002	COX-2 and mPGES-1 are essential components for delayed PGE2 synthesis, which may be linked to inflammation, fever, osteogenesis, and even cancer.	Dinoprostone	55-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
12468269-4	2002	An increase in COX-2 immunoreactive protein was also seen after incubation of isolated human adipocytes for 48 h. The release of PGE(2) by adipocytes incubated for 48 h was about 4% that by intact adipose tissue explants while the release of prostacyclin was about 1.5% that by tissue.	Prostaglandins E	129-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-20
12468269-4	2002	An increase in COX-2 immunoreactive protein was also seen after incubation of isolated human adipocytes for 48 h. The release of PGE(2) by adipocytes incubated for 48 h was about 4% that by intact adipose tissue explants while the release of prostacyclin was about 1.5% that by tissue.	Epoprostenol	242-254	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-20
12468269-6	2002	Dexamethasone enhanced leptin release by adipocytes while inhibiting PGE(2) release and COX-2 up-regulation.	Dexamethasone	0-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-93
12468269-7	2002	The mechanisms involved in up-regulation of COX-2 activity during primary culture of adipocytes and the inhibition of this by dexamethasone do not appear to involve p38 MAPK or p42-44 MAPK.	Dexamethasone	126-139	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-49
12511101-9	2002	From the kinetic point of view, it is found that the thermal stability of the complexes follows the order Ni(II) &gt; Cu(II) &gt; Zn(II) &gt; Fe(III) &gt; Co(II) &gt; Cd(II).	Nickel(2+)	106-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	155-161
12511101-9	2002	From the kinetic point of view, it is found that the thermal stability of the complexes follows the order Ni(II) &gt; Cu(II) &gt; Zn(II) &gt; Fe(III) &gt; Co(II) &gt; Cd(II).	cu(ii)	118-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	155-161
12511101-9	2002	From the kinetic point of view, it is found that the thermal stability of the complexes follows the order Ni(II) &gt; Cu(II) &gt; Zn(II) &gt; Fe(III) &gt; Co(II) &gt; Cd(II).	Zinc	130-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	155-161
12511101-9	2002	From the kinetic point of view, it is found that the thermal stability of the complexes follows the order Ni(II) &gt; Cu(II) &gt; Zn(II) &gt; Fe(III) &gt; Co(II) &gt; Cd(II).	ferric sulfate	142-149	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	155-161
12511101-9	2002	From the kinetic point of view, it is found that the thermal stability of the complexes follows the order Ni(II) &gt; Cu(II) &gt; Zn(II) &gt; Fe(III) &gt; Co(II) &gt; Cd(II).	cd(ii)	167-173	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	155-161
12237297-2	2002	We showed previously that decreased extracellular salt or chloride up-regulates the cortical thick ascending limb of Henle (cTALH) COX-2 expression via a p38-dependent pathway.	Salts	50-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-136
12237297-2	2002	We showed previously that decreased extracellular salt or chloride up-regulates the cortical thick ascending limb of Henle (cTALH) COX-2 expression via a p38-dependent pathway.	Chlorides	58-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-136
12237297-3	2002	The present studies determined that low salt medium increased COX-2 mRNA expression 3.9-fold control by 6 h in cultured cTALH, which was blocked by actinomycin D pretreatment, suggesting transcriptional regulation.	low salt medium	36-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
12237297-3	2002	The present studies determined that low salt medium increased COX-2 mRNA expression 3.9-fold control by 6 h in cultured cTALH, which was blocked by actinomycin D pretreatment, suggesting transcriptional regulation.	Dactinomycin	148-161	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
12237297-4	2002	Luciferase activity (normalized to beta-galactosidase activity) of the full-length (-3400) COX-2 promoter in cTALH increased from 1.8 +/- 0.3 in control media to 5.8 +/- 0.7 in low salt (n = 9; p &lt; 0.01).	Salts	181-185	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-96
12237297-5	2002	Low chloride medium had similar effects as low salt has on COX-2 promoter activity.	Chlorides	4-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-64
12237297-5	2002	Low chloride medium had similar effects as low salt has on COX-2 promoter activity.	Salts	47-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-64
12237297-8	2002	Co-incubation of the specific p38 inhibitor, SB203580 or PD169316, inhibited a low salt-induced increase in luciferase activity of the intact COX-2 promoter (5.8 +/- 0.7 versus 1.1 +/- 0.2, n = 8 and 1.4 +/- 0.4, n = 4 respectively, p &lt; 0.01).	SB 203580	45-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	142-147
12237297-8	2002	Co-incubation of the specific p38 inhibitor, SB203580 or PD169316, inhibited a low salt-induced increase in luciferase activity of the intact COX-2 promoter (5.8 +/- 0.7 versus 1.1 +/- 0.2, n = 8 and 1.4 +/- 0.4, n = 4 respectively, p &lt; 0.01).	2-(4-nitrophenyl)-4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazole	57-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	142-147
12237297-8	2002	Co-incubation of the specific p38 inhibitor, SB203580 or PD169316, inhibited a low salt-induced increase in luciferase activity of the intact COX-2 promoter (5.8 +/- 0.7 versus 1.1 +/- 0.2, n = 8 and 1.4 +/- 0.4, n = 4 respectively, p &lt; 0.01).	Salts	83-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	142-147
12392741-0	2002	Discovery of a potent and selective COX-2 inhibitor in the alkoxy lactone series with optimized metabolic profile.	alkoxy lactone	59-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-41
12392741-1	2002	The COX-2 inhibitor DFP [5,5-dimethyl-3-(2-propoxy)-4-methanesulfonylphenyl)-2(5H)-furanone] was found to have a long half-life in humans.	Isoflurophate	20-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
12392741-1	2002	The COX-2 inhibitor DFP [5,5-dimethyl-3-(2-propoxy)-4-methanesulfonylphenyl)-2(5H)-furanone] was found to have a long half-life in humans.	5,5-dimethyl-3-(2-propoxy)-4-methanesulfonylphenyl)-2(5h)-furanone	25-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
12438270-7	2002	Inhibition of COX-2 by celecoxib resulted in loss of intratumor PGE2 levels and reduced tumor growth in a dose-dependent manner.	Celecoxib	23-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
12438270-7	2002	Inhibition of COX-2 by celecoxib resulted in loss of intratumor PGE2 levels and reduced tumor growth in a dose-dependent manner.	Dinoprostone	64-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
12438270-11	2002	These data indicate that a major antitumor mechanism of action of celecoxib is inhibition of COX-2-derived prostaglandins, particularly PGE2, and suggest celecoxib as a novel therapeutic agent for human head and neck cancer.	Celecoxib	66-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-98
12438270-11	2002	These data indicate that a major antitumor mechanism of action of celecoxib is inhibition of COX-2-derived prostaglandins, particularly PGE2, and suggest celecoxib as a novel therapeutic agent for human head and neck cancer.	Prostaglandins	107-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-98
12417326-2	2002	Celecoxib strongly suppressed the proliferation of COX-2 expressing HT-29 cells at 10-40 microM.	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-56
12417326-5	2002	DNA fragmentation was also increasd in COX-2 non-expressing cell lines (SW-480 and HCT-116) by exposure to celecoxib for 6-24 h. All six COX-2 inhibitors suppressed the production of prostaglandin E(2) by HT-29 cells, suggesting that the pro-apoptotic effect of celecoxib was unrelated to inhibition of COX-2.	Celecoxib	107-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-44
12417326-5	2002	DNA fragmentation was also increasd in COX-2 non-expressing cell lines (SW-480 and HCT-116) by exposure to celecoxib for 6-24 h. All six COX-2 inhibitors suppressed the production of prostaglandin E(2) by HT-29 cells, suggesting that the pro-apoptotic effect of celecoxib was unrelated to inhibition of COX-2.	Celecoxib	107-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-142
12417326-5	2002	DNA fragmentation was also increasd in COX-2 non-expressing cell lines (SW-480 and HCT-116) by exposure to celecoxib for 6-24 h. All six COX-2 inhibitors suppressed the production of prostaglandin E(2) by HT-29 cells, suggesting that the pro-apoptotic effect of celecoxib was unrelated to inhibition of COX-2.	Celecoxib	107-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-142
12417326-5	2002	DNA fragmentation was also increasd in COX-2 non-expressing cell lines (SW-480 and HCT-116) by exposure to celecoxib for 6-24 h. All six COX-2 inhibitors suppressed the production of prostaglandin E(2) by HT-29 cells, suggesting that the pro-apoptotic effect of celecoxib was unrelated to inhibition of COX-2.	Prostaglandins E	183-198	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-44
12417326-5	2002	DNA fragmentation was also increasd in COX-2 non-expressing cell lines (SW-480 and HCT-116) by exposure to celecoxib for 6-24 h. All six COX-2 inhibitors suppressed the production of prostaglandin E(2) by HT-29 cells, suggesting that the pro-apoptotic effect of celecoxib was unrelated to inhibition of COX-2.	Prostaglandins E	183-198	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-142
12417326-5	2002	DNA fragmentation was also increasd in COX-2 non-expressing cell lines (SW-480 and HCT-116) by exposure to celecoxib for 6-24 h. All six COX-2 inhibitors suppressed the production of prostaglandin E(2) by HT-29 cells, suggesting that the pro-apoptotic effect of celecoxib was unrelated to inhibition of COX-2.	Prostaglandins E	183-198	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-142
12417326-5	2002	DNA fragmentation was also increasd in COX-2 non-expressing cell lines (SW-480 and HCT-116) by exposure to celecoxib for 6-24 h. All six COX-2 inhibitors suppressed the production of prostaglandin E(2) by HT-29 cells, suggesting that the pro-apoptotic effect of celecoxib was unrelated to inhibition of COX-2.	Celecoxib	262-271	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-44
12417326-5	2002	DNA fragmentation was also increasd in COX-2 non-expressing cell lines (SW-480 and HCT-116) by exposure to celecoxib for 6-24 h. All six COX-2 inhibitors suppressed the production of prostaglandin E(2) by HT-29 cells, suggesting that the pro-apoptotic effect of celecoxib was unrelated to inhibition of COX-2.	Celecoxib	262-271	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-142
12417326-5	2002	DNA fragmentation was also increasd in COX-2 non-expressing cell lines (SW-480 and HCT-116) by exposure to celecoxib for 6-24 h. All six COX-2 inhibitors suppressed the production of prostaglandin E(2) by HT-29 cells, suggesting that the pro-apoptotic effect of celecoxib was unrelated to inhibition of COX-2.	Celecoxib	262-271	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-142
12458428-1	2002	Quenching of the fluorescence of a Leonardite humic acid by Co(II) has been studied at different pH.	Humic Substances	46-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-66
12508788-0	2002	A selective COX-2 inhibitor, meloxicam, as a treatment option in patients with juvenile idiopathic arthritis and gastrointestinal side effects from naproxen.	Meloxicam	29-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-17
12508788-0	2002	A selective COX-2 inhibitor, meloxicam, as a treatment option in patients with juvenile idiopathic arthritis and gastrointestinal side effects from naproxen.	Naproxen	148-156	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-17
12410658-0	2002	Factor-sparing use of the COX-2 inhibitor rofecoxib in haemophilic arthropathy.	rofecoxib	42-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-31
12414874-3	2002	Estrogen-induced responses in vascular cells have been shown to influence prostaglandins and cyclooxygenase (COX), a key enzyme in the production of prostaglandins, with two isoforms, COX-1 and COX-2.	Prostaglandins	74-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	194-199
12414874-3	2002	Estrogen-induced responses in vascular cells have been shown to influence prostaglandins and cyclooxygenase (COX), a key enzyme in the production of prostaglandins, with two isoforms, COX-1 and COX-2.	Prostaglandins	149-163	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	194-199
12797647-1	2002	Valdecoxib, a COX-2 inhibitor, has been introduced as a new treatment for osteo-arthritis (OA).	valdecoxib	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
12386924-7	2002	Furthermore, addition of the major metabolites of COX-2-mediated arachidonic acid metabolism did not alter the proliferation of LNCaP-COX-2 cells in vitro.	Arachidonic Acid	65-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-55
12355421-9	2002	These results suggest that prostaglandins, synthesized by COX-1 or COX-2, may contribute to normal physiological and homeostatic functions in the retina.	Prostaglandins	27-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-72
12406402-0	2002	[First spontaneous reports of adverse drug reactions to the new selective COX-2 non-steroid anti-inflammatory drugs].	Steroids	84-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
12270500-9	2002	COX-2 and in part COX-1-selective inhibitors inhibited LPS-induced PGE(2) secretion, whereas the AA-induced PGE(2) secretion was reduced by COX-1-selective inhibitors only.	Dinoprostone	67-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
12225948-6	2002	The COX inhibitor indomethacin, the COX-2 inhibitor NS-398, the protein synthesis inhibitor cycloheximide, and the glucocorticoid dexamethasone abrogated the increased PGE(2) levels.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	52-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-41
12225948-6	2002	The COX inhibitor indomethacin, the COX-2 inhibitor NS-398, the protein synthesis inhibitor cycloheximide, and the glucocorticoid dexamethasone abrogated the increased PGE(2) levels.	Dinoprostone	168-174	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-41
12225948-7	2002	Dexamethasone and cycloheximide prevented COX-2 induction.	Dexamethasone	0-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47
12225948-7	2002	Dexamethasone and cycloheximide prevented COX-2 induction.	Cycloheximide	18-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47
12225948-8	2002	Hypoxia (3% O(2)-5% CO(2)-92% N(2)) for 24 h selectively augmented TGF-beta1-stimulated PGE(2) production and COX-2 induction but had no effect alone.	o(2)	12-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-115
12225948-8	2002	Hypoxia (3% O(2)-5% CO(2)-92% N(2)) for 24 h selectively augmented TGF-beta1-stimulated PGE(2) production and COX-2 induction but had no effect alone.	co(2)	20-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-115
12225948-8	2002	Hypoxia (3% O(2)-5% CO(2)-92% N(2)) for 24 h selectively augmented TGF-beta1-stimulated PGE(2) production and COX-2 induction but had no effect alone.	Nitrogen	30-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-115
12377741-1	2002	OBJECTIVE: Cyclooxygenase (COX)-2 is a key regulatory enzyme in the synthesis of prostanoids associated with trauma and inflammation.	Prostaglandins	81-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-33
12359744-2	2002	The aim of this study was to determine whether celecoxib, a selective Cox-2 inhibitor, protected against HER-2/neu-induced experimental breast cancer.	Celecoxib	47-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-75
12426134-7	2002	Although all proteins were inhibited by Cd(II) and Cu(II), XPA and PARP but not Fpg were inhibited by Co(II) and Ni(II).	cu(ii)	51-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-108
12374774-5	2002	The PAR-1-induced chloride secretory response was significantly attenuated by inhibitors of the EGF receptor tyrosine kinase, Src-kinase, MEK1/2, as well as by inhibitors of cytosolic phospholipase (cPL) A2, COX-1 and COX-2.	Chlorides	18-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	218-223
12517972-8	2003	Pretreatment with dexamethasone suppressed COX-2 expression, PGE(2) release, and COX activity induced by NS-398, Cig, IL-1beta, alone or in combination.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	105-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
12517972-8	2003	Pretreatment with dexamethasone suppressed COX-2 expression, PGE(2) release, and COX activity induced by NS-398, Cig, IL-1beta, alone or in combination.	ciglitazone	113-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
12517972-10	2003	Indo, NS-398, Flur, and 15d-PGJ(2), but not WY-14643, induced transcriptional activity of a COX-2 reporter construct containing the peroxisome proliferator response element (PPRE) on their own and enhanced the effect of IL-1beta, but had no effect on a COX-2 reporter construct lacking the PPRE.	Indomethacin	0-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-97
12517972-10	2003	Indo, NS-398, Flur, and 15d-PGJ(2), but not WY-14643, induced transcriptional activity of a COX-2 reporter construct containing the peroxisome proliferator response element (PPRE) on their own and enhanced the effect of IL-1beta, but had no effect on a COX-2 reporter construct lacking the PPRE.	Indomethacin	0-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	253-258
12517972-10	2003	Indo, NS-398, Flur, and 15d-PGJ(2), but not WY-14643, induced transcriptional activity of a COX-2 reporter construct containing the peroxisome proliferator response element (PPRE) on their own and enhanced the effect of IL-1beta, but had no effect on a COX-2 reporter construct lacking the PPRE.	Nitrogen	6-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-97
12517972-10	2003	Indo, NS-398, Flur, and 15d-PGJ(2), but not WY-14643, induced transcriptional activity of a COX-2 reporter construct containing the peroxisome proliferator response element (PPRE) on their own and enhanced the effect of IL-1beta, but had no effect on a COX-2 reporter construct lacking the PPRE.	Nitrogen	6-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	253-258
12517972-10	2003	Indo, NS-398, Flur, and 15d-PGJ(2), but not WY-14643, induced transcriptional activity of a COX-2 reporter construct containing the peroxisome proliferator response element (PPRE) on their own and enhanced the effect of IL-1beta, but had no effect on a COX-2 reporter construct lacking the PPRE.	-pgj	27-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-97
12517972-10	2003	Indo, NS-398, Flur, and 15d-PGJ(2), but not WY-14643, induced transcriptional activity of a COX-2 reporter construct containing the peroxisome proliferator response element (PPRE) on their own and enhanced the effect of IL-1beta, but had no effect on a COX-2 reporter construct lacking the PPRE.	-pgj	27-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	253-258
12517972-11	2003	The results suggest that COX-2 expression by NSAIDs is biologically functional, prostanoid-independent, and involves PPARgamma activation, and provide the first direct evidence that the PPRE in the promoter is required for NSAID-induced COX-2 expression.	Prostaglandins	80-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-30
12446609-5	2002	Systemic injection of both cytokines caused a rapid and transient transcriptional activation of COX-2 gene within the cerebral microvasculature, which was significantly enhanced by ketorolac.	Ketorolac	181-190	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-101
12446609-9	2002	In contrast, exogenous corticosterone abolished the effects of ketorolac on IL-1beta-induced COX-2 and monocyte chemoattractant protein-1 gene expression in the cerebral endothelium.	Corticosterone	23-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-98
12446609-9	2002	In contrast, exogenous corticosterone abolished the effects of ketorolac on IL-1beta-induced COX-2 and monocyte chemoattractant protein-1 gene expression in the cerebral endothelium.	Ketorolac	63-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-98
12914175-1	2002	This article investigated UV, IR and 1H-NMR spectra characteristics of the complexes which are formed by glucosamine and Fe (II), Zn (II), Co (II), Cu (II) respectively.	Hydrogen	37-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-155
12914175-1	2002	This article investigated UV, IR and 1H-NMR spectra characteristics of the complexes which are formed by glucosamine and Fe (II), Zn (II), Co (II), Cu (II) respectively.	Glucosamine	105-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-155
12914175-1	2002	This article investigated UV, IR and 1H-NMR spectra characteristics of the complexes which are formed by glucosamine and Fe (II), Zn (II), Co (II), Cu (II) respectively.	fe (ii)	121-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-155
12914175-5	2002	This article also researched the syntheses of the complexes of the carboxymethyl glucosamine with Fe (II), Co (II), Cu (II) and pointed out that it is the rigidity of the sugar ring that leads to an abnormal phenomenon that the spectral lines" number of the complexes is the same as that of the carboxymethyl glucosamine.	carboxymethyl glucosamine	67-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-123
12914175-5	2002	This article also researched the syntheses of the complexes of the carboxymethyl glucosamine with Fe (II), Co (II), Cu (II) and pointed out that it is the rigidity of the sugar ring that leads to an abnormal phenomenon that the spectral lines" number of the complexes is the same as that of the carboxymethyl glucosamine.	Sugars	171-176	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-123
12914175-5	2002	This article also researched the syntheses of the complexes of the carboxymethyl glucosamine with Fe (II), Co (II), Cu (II) and pointed out that it is the rigidity of the sugar ring that leads to an abnormal phenomenon that the spectral lines" number of the complexes is the same as that of the carboxymethyl glucosamine.	carboxymethyl glucosamine	295-320	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-123
12438520-0	2002	Origins of prostaglandin E2: involvements of cyclooxygenase (COX)-1 and COX-2 in human and rat systems.	Dinoprostone	11-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
12438520-2	2002	Using rats in vivo and rat and human blood in vitro, we have examined the roles of COX-1 and COX-2 in the production of PGE2.	Dinoprostone	120-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-98
12460774-9	2002	The results show that purified mPGES-1 has a specific activity similar to Cox-2, consistent with its postulated role in Cox-2 mediated PGE(2) formation.	Prostaglandins E	32-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-125
12468261-5	2002	DMSO-induced HL-60 cells gained induction of TXB(2) synthesis and mRNA for COX-2 and TXA(2) synthase during granulocytic differentiation.	Dimethyl Sulfoxide	0-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
12468261-7	2002	A23187-stimulated TXB(2) production in DMSO-treated cells was inhibited by NS-398, a specific COX-2 inhibitor.	Calcimycin	0-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-99
12468261-7	2002	A23187-stimulated TXB(2) production in DMSO-treated cells was inhibited by NS-398, a specific COX-2 inhibitor.	Thromboxane B2	18-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-99
12468261-7	2002	A23187-stimulated TXB(2) production in DMSO-treated cells was inhibited by NS-398, a specific COX-2 inhibitor.	Dimethyl Sulfoxide	39-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-99
12468261-7	2002	A23187-stimulated TXB(2) production in DMSO-treated cells was inhibited by NS-398, a specific COX-2 inhibitor.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	75-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-99
12528072-2	2002	Both COX isoforms (COX-1 and COX-2) constitutively are expressed in the adult mammalian kidney and contribute to the biosynthesis of prostaglandins (PGs).	Prostaglandins	133-147	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34
12528072-2	2002	Both COX isoforms (COX-1 and COX-2) constitutively are expressed in the adult mammalian kidney and contribute to the biosynthesis of prostaglandins (PGs).	Prostaglandins	149-152	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34
12439937-2	2002	METHODS: RNA of hydrogen peroxide-induced SW-480 cells was isolated, and reverse-transcriptional polymerase chain reaction was performed to study gene expression of ATPase subunit 6, ATPase subunit 8, cytochrome c oxidase subunit I (COI), cytochrome coxidase subuit II (COII) and cytochrome c oxidase subunit III (COIII).	Hydrogen Peroxide	16-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	250-268
12439937-2	2002	METHODS: RNA of hydrogen peroxide-induced SW-480 cells was isolated, and reverse-transcriptional polymerase chain reaction was performed to study gene expression of ATPase subunit 6, ATPase subunit 8, cytochrome c oxidase subunit I (COI), cytochrome coxidase subuit II (COII) and cytochrome c oxidase subunit III (COIII).	Hydrogen Peroxide	16-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	270-274
12237321-4	2002	Here we investigated the role of the COX-2 metabolites PGE(2) and TXA2 in regulating human umbilical vein endothelial cell (HUVEC) adhesion and spreading.	Prostaglandins E	55-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-42
12237321-7	2002	alpha(V)beta(3)-mediated adhesion induced a transient COX-2-dependent rise in cAMP levels, whereas the cell-permeable cAMP analogue 8-brcAMP accelerated adhesion, promoted Rac activation, and cell spreading in the presence of the COX-2 inhibitor NS-398.	Cyclic AMP	78-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-59
12237321-7	2002	alpha(V)beta(3)-mediated adhesion induced a transient COX-2-dependent rise in cAMP levels, whereas the cell-permeable cAMP analogue 8-brcAMP accelerated adhesion, promoted Rac activation, and cell spreading in the presence of the COX-2 inhibitor NS-398.	8-Bromo Cyclic Adenosine Monophosphate	132-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	230-235
12237321-11	2002	In conclusion, these results demonstrate that PGE(2) accelerates alpha(V)beta(3)-mediated endothelial cell adhesion through cAMP-dependent PKA activation and induces alpha(V)beta(3)-dependent spreading via cAMP- and PKA-dependent Rac activation and may contribute to the further understanding of the regulation of vascular integrins alpha(V)beta(3) by COX-2/PGE(2) during tumor angiogenesis and inflammation.	Prostaglandins E	46-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	352-357
12417253-1	2002	Recently, under large-scale screening experiments, we found that sphondin, a furanocoumarin derivative isolated from Heracleum laciniatum, possessed an inhibitory effect on IL-1beta-induced increase in the level of COX-2 protein and PGE(2) release in A549 cells.	sphondin	65-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	215-220
12417253-2	2002	Accordingly, we examined in the present study the action mechanism of sphondin on the inhibition of IL-1beta-induced COX-2 protein expression and PGE(2) release in a human pulmonary epithelial cell line (A549).	sphondin	70-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-122
12417253-3	2002	Pretreatment of cells with sphondin (10-50 microM) concentration-dependently attenuated IL-1beta-induced COX-2 protein expression and PGE(2) release.	sphondin	27-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-110
12417253-4	2002	The IL-1beta-induced increase in COX-2 mRNA expression was also attenuated by sphondin (50 microM).	sphondin	78-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-38
12417253-5	2002	The selective COX-2 inhibitor, NS-398 (0.01-1 microM), inhibited the activity of the COX-2 enzyme in a concentration-dependent manner, while sphondin (10-50 microM) had no effect.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	31-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
12417253-5	2002	The selective COX-2 inhibitor, NS-398 (0.01-1 microM), inhibited the activity of the COX-2 enzyme in a concentration-dependent manner, while sphondin (10-50 microM) had no effect.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	31-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-90
12417253-9	2002	Taken together, we demonstrate that sphondin inhibits IL-1beta-induced PGE(2) release in A549 cells; this inhibition is mediated by suppressing of COX-2 expression, rather than by inhibiting COX-2 enzyme activity.	sphondin	36-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-152
12417253-10	2002	The inhibitory mechanism of sphondin on IL-1beta-induced COX-2 expression may be, at least in part, through suppression of NF-kappaB activity.	sphondin	28-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-62
12438270-6	2002	We report here that 1483 human head and neck xenograft tumors express COX-2 similar to the pattern observed in human solid tumors and that COX-2 activity produces high levels of prostaglandin E2 (PGE2).	Dinoprostone	178-194	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-144
12438270-6	2002	We report here that 1483 human head and neck xenograft tumors express COX-2 similar to the pattern observed in human solid tumors and that COX-2 activity produces high levels of prostaglandin E2 (PGE2).	Dinoprostone	196-200	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-144
12408728-0	2002	Spectral and crystallographic study of pyridinic analogues of nimesulide: determination of the active form of methanesulfonamides as COX-2 selective inhibitors.	nimesulide	62-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	133-138
12408728-0	2002	Spectral and crystallographic study of pyridinic analogues of nimesulide: determination of the active form of methanesulfonamides as COX-2 selective inhibitors.	methanesulfonamide	110-129	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	133-138
12408728-1	2002	Compound 7, N-(3-phenoxy-4-pyridinyl)trifluoromethanesulfonamide, showed in vitro (whole blood assay) a strong inhibitory activity on the two cyclooxygenase (COX) enzymes (IC(50)(COX-1) = 2.2 microM and IC(50)(COX-2) = 0.4 microM), being more active but less COX-2-selective than nimesulide.	n-(3-phenoxy-4-pyridinyl	12-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	210-215
12408728-1	2002	Compound 7, N-(3-phenoxy-4-pyridinyl)trifluoromethanesulfonamide, showed in vitro (whole blood assay) a strong inhibitory activity on the two cyclooxygenase (COX) enzymes (IC(50)(COX-1) = 2.2 microM and IC(50)(COX-2) = 0.4 microM), being more active but less COX-2-selective than nimesulide.	n-(3-phenoxy-4-pyridinyl	12-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	259-264
12526218-11	2002	In 40 paraffin embedded specimens of BTCC, the intensity of COX-2 expression was associated with tumor grade and stage.	Paraffin	6-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-65
12485854-3	2002	Contrary to the above notion, we have found that H-ras-transformed human breast epithelial (MCF10A-ras) cells treated with the anticancer drug ET-18-O-CH(3) exhibit an increased expression of COX-2, while they still undergo apoptosis.	et-18-o-ch	143-153	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	192-197
12485854-4	2002	To determine whether the induction of COX-2 by ET-18-O-CH(3) could contribute to apoptosis in MCF10A-ras cells, the selective COX-2 inhibitor celecoxib (SC-58635) was used.	et-18-o-ch	47-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-43
12485854-4	2002	To determine whether the induction of COX-2 by ET-18-O-CH(3) could contribute to apoptosis in MCF10A-ras cells, the selective COX-2 inhibitor celecoxib (SC-58635) was used.	Celecoxib	142-151	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-43
12439336-2	2002	In the present study the effect of nimesulide (NIM), a specific COX-2 inhibitor, on apoptosis and interactions between BCL-2 family death promoters BAX and BID and BAX and VDAC-1 were examined in human colon adenocarcinoma COLO 205 cells.	nimesulide	35-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-69
12423318-0	2002	COX-2-independent antiproliferative action of acetylsalicylic acid in human colon cancer cells.	Aspirin	46-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
12391247-4	2002	We observed that adenosine up-regulates the expression of the COX-2 enzyme and mRNA.	Adenosine	17-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
12391247-5	2002	Production of PGE(2) in response to exogenous arachidonic acid was also increased by adenosine and correlated with COX-2 protein levels.	Prostaglandins E	14-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-120
12391247-5	2002	Production of PGE(2) in response to exogenous arachidonic acid was also increased by adenosine and correlated with COX-2 protein levels.	Arachidonic Acid	46-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-120
12391247-6	2002	The potentiating effect of adenosine on COX-2 could be mimicked by pharmacological increases of intracellular cAMP levels, involving the latter as a putative second messenger for the up-regulation of COX-2 by adenosine.	Adenosine	27-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
12391247-6	2002	The potentiating effect of adenosine on COX-2 could be mimicked by pharmacological increases of intracellular cAMP levels, involving the latter as a putative second messenger for the up-regulation of COX-2 by adenosine.	Adenosine	27-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	200-205
12391247-6	2002	The potentiating effect of adenosine on COX-2 could be mimicked by pharmacological increases of intracellular cAMP levels, involving the latter as a putative second messenger for the up-regulation of COX-2 by adenosine.	Cyclic AMP	110-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
12391247-6	2002	The potentiating effect of adenosine on COX-2 could be mimicked by pharmacological increases of intracellular cAMP levels, involving the latter as a putative second messenger for the up-regulation of COX-2 by adenosine.	Cyclic AMP	110-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	200-205
12391247-6	2002	The potentiating effect of adenosine on COX-2 could be mimicked by pharmacological increases of intracellular cAMP levels, involving the latter as a putative second messenger for the up-regulation of COX-2 by adenosine.	Adenosine	209-218	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
12391247-6	2002	The potentiating effect of adenosine on COX-2 could be mimicked by pharmacological increases of intracellular cAMP levels, involving the latter as a putative second messenger for the up-regulation of COX-2 by adenosine.	Adenosine	209-218	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	200-205
12391247-7	2002	Specific COX-2 inhibitors were used to confirm the predominant role of the COX-2 isoform in the formation of prostanoids by stimulated PMNs.	Prostaglandins	109-120	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	9-14
12391247-7	2002	Specific COX-2 inhibitors were used to confirm the predominant role of the COX-2 isoform in the formation of prostanoids by stimulated PMNs.	Prostaglandins	109-120	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
12379927-0	2002	Complexes of Co(II) and Zn(II) with ofloxacin.	Ofloxacin	36-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-19
12379927-2	2002	Ofloxacin (oflo) is able to interact with Co(II) and Zn(II) salts to form complexes with the general formula [M(oflo)(2)].	Ofloxacin	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-48
12379927-2	2002	Ofloxacin (oflo) is able to interact with Co(II) and Zn(II) salts to form complexes with the general formula [M(oflo)(2)].	Ofloxacin	11-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-48
12379927-8	2002	4MeOH, where Co(II) ion is in an octahedral environment of oxygen atoms.	Oxygen	59-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-19
12406411-0	2002	[Economic evaluation of a new selective COX-2 NSAID, rofecoxib, in a real practice context].	rofecoxib	53-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
12487927-9	2002	(3) COX-2 expression was correlated with PGE(2), 6-keto-PGF(1 alpha) and TXB(2) (P &lt; 0.01).	Prostaglandins E	41-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
12487927-9	2002	(3) COX-2 expression was correlated with PGE(2), 6-keto-PGF(1 alpha) and TXB(2) (P &lt; 0.01).	6-keto-pgf	49-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
12487927-10	2002	CONCLUSIONS: (1) Our data suggest that COX-2 overexpression leads to increased PGE(2), 6-keto-PGF(1 alpha) and TXB(2) biosynthesis, which may be mechanisms underlying the contribution of COX-2 to the development of ovarian serous carcinoma.	Prostaglandins E	79-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-44
12487927-10	2002	CONCLUSIONS: (1) Our data suggest that COX-2 overexpression leads to increased PGE(2), 6-keto-PGF(1 alpha) and TXB(2) biosynthesis, which may be mechanisms underlying the contribution of COX-2 to the development of ovarian serous carcinoma.	Prostaglandins E	79-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	187-192
12487927-10	2002	CONCLUSIONS: (1) Our data suggest that COX-2 overexpression leads to increased PGE(2), 6-keto-PGF(1 alpha) and TXB(2) biosynthesis, which may be mechanisms underlying the contribution of COX-2 to the development of ovarian serous carcinoma.	6-keto-pgf	87-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-44
12487927-10	2002	CONCLUSIONS: (1) Our data suggest that COX-2 overexpression leads to increased PGE(2), 6-keto-PGF(1 alpha) and TXB(2) biosynthesis, which may be mechanisms underlying the contribution of COX-2 to the development of ovarian serous carcinoma.	(2s,3r,4r,5r)-5-Sulfanyloxane-2,3,4-Triol	111-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-44
12487927-10	2002	CONCLUSIONS: (1) Our data suggest that COX-2 overexpression leads to increased PGE(2), 6-keto-PGF(1 alpha) and TXB(2) biosynthesis, which may be mechanisms underlying the contribution of COX-2 to the development of ovarian serous carcinoma.	(2s,3r,4r,5r)-5-Sulfanyloxane-2,3,4-Triol	111-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	187-192
12391014-1	2002	Aspirin (ASA) is unique among current therapies because it acetylates cyclooxygenase (COX)-2 enabling the biosynthesis of R-containing precursors of endogenous antiinflammatory mediators.	Aspirin	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-92
12391014-1	2002	Aspirin (ASA) is unique among current therapies because it acetylates cyclooxygenase (COX)-2 enabling the biosynthesis of R-containing precursors of endogenous antiinflammatory mediators.	Aspirin	9-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-92
12391014-4	2002	Human COX-2 converted DHA to 13-hydroxy-DHA that switched with ASA to 17R-HDHA that also proved a major route in hypoxic endothelial cells.	Docosahexaenoic Acids	22-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	6-11
12391014-4	2002	Human COX-2 converted DHA to 13-hydroxy-DHA that switched with ASA to 17R-HDHA that also proved a major route in hypoxic endothelial cells.	13-hydroxy-dha	29-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	6-11
12391014-4	2002	Human COX-2 converted DHA to 13-hydroxy-DHA that switched with ASA to 17R-HDHA that also proved a major route in hypoxic endothelial cells.	Aspirin	63-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	6-11
12391014-5	2002	Human neutrophils transformed COX-2-ASA-derived 17R-hydroxy-DHA into two sets of novel di- and trihydroxy products; one initiated via oxygenation at carbon 7 and the other at carbon 4.	Aspirin	36-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-35
12391014-5	2002	Human neutrophils transformed COX-2-ASA-derived 17R-hydroxy-DHA into two sets of novel di- and trihydroxy products; one initiated via oxygenation at carbon 7 and the other at carbon 4.	17r-hydroxy-dha	48-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-35
12391014-5	2002	Human neutrophils transformed COX-2-ASA-derived 17R-hydroxy-DHA into two sets of novel di- and trihydroxy products; one initiated via oxygenation at carbon 7 and the other at carbon 4.	Carbon	149-155	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-35
12391014-5	2002	Human neutrophils transformed COX-2-ASA-derived 17R-hydroxy-DHA into two sets of novel di- and trihydroxy products; one initiated via oxygenation at carbon 7 and the other at carbon 4.	Carbon	175-181	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-35
12209459-1	2002	The generation of singlet molecular oxygen ((1)O(2)) and hydroxyl radicals (HO*) during peroxidation of bopindolol in the presence of Co(II) ions was studied using electron spin resonance (ESR) and spectrophotometry methods.	Oxygen	18-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-140
12209459-1	2002	The generation of singlet molecular oxygen ((1)O(2)) and hydroxyl radicals (HO*) during peroxidation of bopindolol in the presence of Co(II) ions was studied using electron spin resonance (ESR) and spectrophotometry methods.	(1)o(2))	44-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-140
12209459-1	2002	The generation of singlet molecular oxygen ((1)O(2)) and hydroxyl radicals (HO*) during peroxidation of bopindolol in the presence of Co(II) ions was studied using electron spin resonance (ESR) and spectrophotometry methods.	Hydroxyl Radical	57-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-140
12209459-1	2002	The generation of singlet molecular oxygen ((1)O(2)) and hydroxyl radicals (HO*) during peroxidation of bopindolol in the presence of Co(II) ions was studied using electron spin resonance (ESR) and spectrophotometry methods.	Holmium	76-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-140
12209459-1	2002	The generation of singlet molecular oxygen ((1)O(2)) and hydroxyl radicals (HO*) during peroxidation of bopindolol in the presence of Co(II) ions was studied using electron spin resonance (ESR) and spectrophotometry methods.	bopindolol	104-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-140
12217369-1	2002	A group of isomers possessing a 2-, 3-, or 4-acetoxy moiety on the 3-phenyl substituent of rofecoxib were synthesized that exhibit highly potent, and selective, COX-2 inhibitory activity that have the potential to acetylate the COX-2 isozyme.	rofecoxib	91-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	161-166
12217369-1	2002	A group of isomers possessing a 2-, 3-, or 4-acetoxy moiety on the 3-phenyl substituent of rofecoxib were synthesized that exhibit highly potent, and selective, COX-2 inhibitory activity that have the potential to acetylate the COX-2 isozyme.	rofecoxib	91-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	228-233
12370831-3	2002	Experiments using semi-quantitative RT-PCR demonstrate that UVA increased the half-life of the COX-2 message by more than fourfold in the presence of Actinomycin D (with a half life between 4 and 8 h post-irradiation), suggesting that UVA induction of COX-2 is post-transcriptionally regulated.	Dactinomycin	150-163	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-100
12370831-3	2002	Experiments using semi-quantitative RT-PCR demonstrate that UVA increased the half-life of the COX-2 message by more than fourfold in the presence of Actinomycin D (with a half life between 4 and 8 h post-irradiation), suggesting that UVA induction of COX-2 is post-transcriptionally regulated.	Dactinomycin	150-163	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	252-257
12370831-4	2002	Through the use of the specific p38 inhibitor, SB202190, increases in COX-2 message and protein levels were abrogated in UVA-irradiated cells.	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	47-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-75
12370831-5	2002	In UVA-irradiated cells treated with SB202190, the half-life of the COX-2 message was decreased to basal levels (between 1 and 2 h post-irradiation), indicating that p38 was responsible for the stabilization of the message.	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	37-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-73
12387625-6	2002	COX-2 promoter activity was induced by ABADA in HCT 116 cells.	abada	39-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
12387696-3	2002	Meloxicam has been shown to be COX-2 preferential, particularly at its lowest therapeutic dose, and is anti-inflammatory by inhibiting prostanoid synthesis in inflammatory cells.	Meloxicam	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-36
12538086-9	2003	Surprisingly, these results disprove our original hypothesis and suggest that inhibition of COX-2 provides additional renoprotection to that of enalapril alone.	Enalapril	144-153	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-97
18968778-2	2002	The QADEAB can react with Co(II) in the presence of pH 3.8 acetic acid-sodium acetate buffer solution and cetyl trimethylammonium bromide (CTMAB) medium to form a violet chelate of a molar ratio 1:2 (cobalt to QADEAB).	Cetrimonium	139-144	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-32
12384172-7	2002	The stimulatory effect of SNAP on the IL-1 beta-induced release of SP was completely inhibited on co-incubation with a selective COX-2 inhibitor, NS-398.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	146-152	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-134
12384172-9	2002	These results suggest that in cultured DRG cells, NO potentiates the IL-1 beta-induced increase in COX-2 expression via a soluble guanylate cyclase-cGMP-independent pathway, resulting in facilitation of SP release.	Cyclic GMP	148-152	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-104
12389882-4	2002	However, COX-2 is also constitutively expressed in the human kidney Clinical studies have reported a significant decrease in glomerular filtration rate in young and elderly sodium-depleted volunteers given COX-2 inhibitors.	Sodium	173-179	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	9-14
12389882-4	2002	However, COX-2 is also constitutively expressed in the human kidney Clinical studies have reported a significant decrease in glomerular filtration rate in young and elderly sodium-depleted volunteers given COX-2 inhibitors.	Sodium	173-179	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	206-211
12389882-5	2002	We describe the case of a 71-year-old woman who developed acute renal failure after receiving a 50-mg dose of the selective COX-2 inhibitor rofecoxib.	rofecoxib	140-149	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	124-129
12396061-1	2002	Novel complexes of Co(II), Ni(II), Cu(II) and Pd(II) with the new ligand [N,N"-bis(2-carboxy-1-oxo-phenelenyl)ethylenediamine] (H2L) have been synthesized and characterized on the basis of elemental analyses, magnetic susceptibility, thermal, infrared, electronic, 1H NMR and EPR spectral studies.	Polydioxanone	46-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-25
12396061-1	2002	Novel complexes of Co(II), Ni(II), Cu(II) and Pd(II) with the new ligand [N,N"-bis(2-carboxy-1-oxo-phenelenyl)ethylenediamine] (H2L) have been synthesized and characterized on the basis of elemental analyses, magnetic susceptibility, thermal, infrared, electronic, 1H NMR and EPR spectral studies.	[n,n"-bis(2-carboxy-1-oxo-phenelenyl)ethylenediamine]	73-126	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-25
12396061-1	2002	Novel complexes of Co(II), Ni(II), Cu(II) and Pd(II) with the new ligand [N,N"-bis(2-carboxy-1-oxo-phenelenyl)ethylenediamine] (H2L) have been synthesized and characterized on the basis of elemental analyses, magnetic susceptibility, thermal, infrared, electronic, 1H NMR and EPR spectral studies.	h2l	128-131	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-25
12396061-1	2002	Novel complexes of Co(II), Ni(II), Cu(II) and Pd(II) with the new ligand [N,N"-bis(2-carboxy-1-oxo-phenelenyl)ethylenediamine] (H2L) have been synthesized and characterized on the basis of elemental analyses, magnetic susceptibility, thermal, infrared, electronic, 1H NMR and EPR spectral studies.	Hydrogen	265-267	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-25
12396061-7	2002	The stability constants were found to follow the order: Mn(II) &lt; Co(II) &lt; Ni(II) &lt; Cu(II) &gt; Zn(II).	Manganese(2+)	56-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-74
12396061-7	2002	The stability constants were found to follow the order: Mn(II) &lt; Co(II) &lt; Ni(II) &lt; Cu(II) &gt; Zn(II).	cu(ii)	92-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-74
12077117-9	2002	Finally, NS 398, a COX-2 inhibitor, partially blocked the effect on PPAR activity and binding to the PPRE suggesting involvement of COX-2 metabolites in PPRE activation.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	9-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-24
12077117-9	2002	Finally, NS 398, a COX-2 inhibitor, partially blocked the effect on PPAR activity and binding to the PPRE suggesting involvement of COX-2 metabolites in PPRE activation.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	9-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-137
12352459-1	2002	PURPOSE: Increased prostaglandin production correlates positively with cancer risk and cyclooxygenase (COX)-2, the inducible rate limiting enzyme for prostaglandin synthesis, is elevated in bladder cancer cases.	Prostaglandins	150-163	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-109
12395741-2	2002	ULCER COMPLICATIONS: The probability of developing a symptomatic, uncomplicated or complicated (perforation, gastric outlet obstruction, bleeding) gastroduodenal ulcer is significantly lower with a COX-2 selective inhibitor (Celecoxib, rofecoxib) than with a traditional NSAIDs, with a reduction in absolute risk of around 1-1.5 for 100 patient-years in clinical trials.	Celecoxib	225-234	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	198-203
12395741-2	2002	ULCER COMPLICATIONS: The probability of developing a symptomatic, uncomplicated or complicated (perforation, gastric outlet obstruction, bleeding) gastroduodenal ulcer is significantly lower with a COX-2 selective inhibitor (Celecoxib, rofecoxib) than with a traditional NSAIDs, with a reduction in absolute risk of around 1-1.5 for 100 patient-years in clinical trials.	rofecoxib	236-245	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	198-203
12395741-4	2002	THE INFLUENCE OF A CO-PRESCRIPTION OF ASPIRIN: Patients for whom low-dose aspirin is indicated to offset known thrombotic risk must continue this therapy if a COX-2 selective inhibitor is introduced.	Aspirin	38-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	159-164
12395741-4	2002	THE INFLUENCE OF A CO-PRESCRIPTION OF ASPIRIN: Patients for whom low-dose aspirin is indicated to offset known thrombotic risk must continue this therapy if a COX-2 selective inhibitor is introduced.	Aspirin	74-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	159-164
18968778-0	2002	Study on the solid phase extraction of Co(II)-QADEAB chelate with C(18) disk and its application to the determination of trace cobalt.	1-octadecene	66-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-45
18968778-0	2002	Study on the solid phase extraction of Co(II)-QADEAB chelate with C(18) disk and its application to the determination of trace cobalt.	Cobalt	127-133	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-45
18968778-2	2002	The QADEAB can react with Co(II) in the presence of pH 3.8 acetic acid-sodium acetate buffer solution and cetyl trimethylammonium bromide (CTMAB) medium to form a violet chelate of a molar ratio 1:2 (cobalt to QADEAB).	qadeab	4-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-32
18968778-2	2002	The QADEAB can react with Co(II) in the presence of pH 3.8 acetic acid-sodium acetate buffer solution and cetyl trimethylammonium bromide (CTMAB) medium to form a violet chelate of a molar ratio 1:2 (cobalt to QADEAB).	acetic acid-sodium acetate	59-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-32
18968778-2	2002	The QADEAB can react with Co(II) in the presence of pH 3.8 acetic acid-sodium acetate buffer solution and cetyl trimethylammonium bromide (CTMAB) medium to form a violet chelate of a molar ratio 1:2 (cobalt to QADEAB).	Cetrimonium	106-137	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-32
12169581-0	2002	Bradykinin increases IL-8 generation in airway epithelial cells via COX-2-derived prostanoids.	Prostaglandins	82-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-73
12184997-8	2002	sCOX contains Val(523) that has been shown to be a key residue determining the sensitivity to COX-2-specific inhibitors including NS-398.	Valine	14-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-99
12184997-8	2002	sCOX contains Val(523) that has been shown to be a key residue determining the sensitivity to COX-2-specific inhibitors including NS-398.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	130-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-99
24728118-5	2002	Particularly in patients treated with low-dose of aspirin for cardiovascular prophylaxis, the COX-2 inhibitors seem to have no obvious advantages over conventional NSAIDs.	Aspirin	50-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-99
12498012-1	2002	The discovery of the two isoenzymes of cyclooxygenase COX-1 and COX-2 and their separate functions, localization and regulation, has initiated the search for new and more selective inhibitors of prostaglandin biosynthesis.	Prostaglandins	195-208	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-69
12498012-4	2002	The discovery of COX-2 in the spinal cord suggests that it is responsible for spinal prostaglandin release in nociceptive processes following a peripheral inflammatory stimulus.	Prostaglandins	85-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22
12498012-5	2002	In the future, selective COX-2 inhibitors such as celecoxib (GD Searle &amp; Co), rofecoxib (Merck &amp; Co Inc) and the recently developed etoricoxib (Merck &amp; Co Inc) may play an important role in the treatment of a wider range of pain conditions in addition to their present use as anti-inflammatory and analgesic drugs.	Celecoxib	50-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-30
12193530-2	2002	The presence of the COX-2/PGIS at the nuclear and endoplasmic reticular membrane suggests differential signaling pathways of PGI(2) actions involving both cell surface and nuclear receptors.	Epoprostenol	125-131	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-25
12169581-7	2002	The dependence of this response on endogenous production of prostanoids by COX-2 suggests that selective COX-2 inhibitors may have a role in the treatment of airway diseases characterized by neutrophilic inflammation such as cystic fibrosis or chronic obstructive pulmonary disease.	Prostaglandins	60-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
12169581-7	2002	The dependence of this response on endogenous production of prostanoids by COX-2 suggests that selective COX-2 inhibitors may have a role in the treatment of airway diseases characterized by neutrophilic inflammation such as cystic fibrosis or chronic obstructive pulmonary disease.	Prostaglandins	60-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-110
18968778-2	2002	The QADEAB can react with Co(II) in the presence of pH 3.8 acetic acid-sodium acetate buffer solution and cetyl trimethylammonium bromide (CTMAB) medium to form a violet chelate of a molar ratio 1:2 (cobalt to QADEAB).	Cobalt	200-206	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-32
18968778-2	2002	The QADEAB can react with Co(II) in the presence of pH 3.8 acetic acid-sodium acetate buffer solution and cetyl trimethylammonium bromide (CTMAB) medium to form a violet chelate of a molar ratio 1:2 (cobalt to QADEAB).	qadeab	210-216	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-32
12193665-0	2002	COX-1 and COX-2 contributions to basal and IL-1 beta-stimulated prostanoid synthesis in human neonatal cerebral microvascular endothelial cells.	Prostaglandins	64-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
12570027-3	2002	Recognition of the two distinct COX isoforms prompted development of drugs that selectively block the activity of COX-2, thus providing pain relief and reducing inflammation while sparing COX-1, the enzyme apparently responsible for most protective prostaglandin synthesis in the mucosa of the stomach and duodenum.	Prostaglandins	249-262	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-119
12205039-4	2002	BK-induced COX-2 expression and prostaglandin E2 (PGE2) accumulation were mimicked by the direct PKC activator phorbol 12-myristate 13-acetate (PMA) and inhibited by the broad spectrum PKC inhibitor bisindolylmaleimide I.	Tetradecanoylphorbol Acetate	111-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-16
12205039-4	2002	BK-induced COX-2 expression and prostaglandin E2 (PGE2) accumulation were mimicked by the direct PKC activator phorbol 12-myristate 13-acetate (PMA) and inhibited by the broad spectrum PKC inhibitor bisindolylmaleimide I.	Tetradecanoylphorbol Acetate	144-147	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-16
12205039-4	2002	BK-induced COX-2 expression and prostaglandin E2 (PGE2) accumulation were mimicked by the direct PKC activator phorbol 12-myristate 13-acetate (PMA) and inhibited by the broad spectrum PKC inhibitor bisindolylmaleimide I.	bisindolylmaleimide I	199-220	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-16
12683422-8	2002	However, COX-2 is also active in the constitutive production of prostanoids in the kidney.	Prostaglandins	64-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	9-14
12193735-12	2002	We propose that 3O-C(12)-HSL induction of Cox-2, membrane-associated PGE synthase, and PGE(2) likely contributes to the inflammation and lung pathology induced by P. aeruginosa infections in the lung.	3o-c	16-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47
12455713-5	2002	The identification of two isoforms of COX (COX-1 or the "constitutive" isoform and COX-2 or the "inducible" isoform) led to the hypothesis that COX-1-derived prostaglandins were involved in regulating physiological functions, whereas COX-2-derived prostaglandins played a major role in inflammation or tissue damage.	Prostaglandins	158-172	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
12455713-5	2002	The identification of two isoforms of COX (COX-1 or the "constitutive" isoform and COX-2 or the "inducible" isoform) led to the hypothesis that COX-1-derived prostaglandins were involved in regulating physiological functions, whereas COX-2-derived prostaglandins played a major role in inflammation or tissue damage.	Prostaglandins	158-172	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	234-239
12455713-5	2002	The identification of two isoforms of COX (COX-1 or the "constitutive" isoform and COX-2 or the "inducible" isoform) led to the hypothesis that COX-1-derived prostaglandins were involved in regulating physiological functions, whereas COX-2-derived prostaglandins played a major role in inflammation or tissue damage.	Prostaglandins	248-262	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
12455713-7	2002	Therefore, rofecoxib and celecoxib, selective inhibitors of COX-2, at least in vitro, were introduced.	rofecoxib	11-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-65
12455713-7	2002	Therefore, rofecoxib and celecoxib, selective inhibitors of COX-2, at least in vitro, were introduced.	Celecoxib	25-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-65
12455713-10	2002	COX-2 inhibitor drugs, such as NSAIDs, reduce sodium excretion, and may cause acute renal failure in patients in whom the maintenance of adequate renal perfusion is "prostaglandin-dependent".	Sodium	46-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
12455713-10	2002	COX-2 inhibitor drugs, such as NSAIDs, reduce sodium excretion, and may cause acute renal failure in patients in whom the maintenance of adequate renal perfusion is "prostaglandin-dependent".	Prostaglandins	166-179	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
12187272-16	2002	Using selective COX-2 inhibitors may be useful for treating prostanoid induced effects associated with ureteral obstruction.	Prostaglandins	60-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-21
12233875-2	2002	We investigated mPGES as well as cyclooxygenase (COX)-2, catalyzing arachidonic acid to PGH2, in synovial cells from patients with rheumatoid arthritis (RA).	Arachidonic Acid	68-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-55
12584888-10	2002	Increased prostacyclin levels in pregnancies complicated by lower genital tract infections are caused by stimulation of COX/2 enzyme, due to elevated production of various cytokines which are possibly a compensatory mechanism resolving problems caused by bacterial endotoxines.	Epoprostenol	10-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-125
12349896-1	2002	Amentoflavone, a biflavonoid with antiinflammatory activity, downregulates COX-2 expression in TNFalpha-activatedA549 cells with concomitant inhibition of NF-kappaB mediated signaling cascades.	amentoflavone	0-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
12349896-4	2002	Hence amentoflavone, a dietary constituent, may be of therapeutic value for several lung diseases where COX-2 plays an important role.	amentoflavone	6-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
12193665-5	2002	Basal and IL-1 beta-stimulated COX activities were inhibited by NS-398, indicating substantial COX-2 contribution to endothelial prostanoid synthesis in neonatal human brain cortex and cerebellum at rest and when mimicking the inflammatory conditions.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	64-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-100
12193665-5	2002	Basal and IL-1 beta-stimulated COX activities were inhibited by NS-398, indicating substantial COX-2 contribution to endothelial prostanoid synthesis in neonatal human brain cortex and cerebellum at rest and when mimicking the inflammatory conditions.	Prostaglandins	129-139	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-100
12193665-8	2002	Acute treatment with the protein tyrosine kinase inhibitor, tyrphostin 25, inhibited basal and IL-1 beta-induced COX activities, suggesting the importance of posttranslational modifications in endothelial COX-2 activation in human brain.	Tyrphostins	60-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	205-210
12193665-9	2002	Altogether, these data indicate that both COX-1 and COX-2 contribute to endothelial prostanoid synthesis in the neonatal human brain under basal conditions and in response to proinflammatory cytokine IL-1 beta.	Prostaglandins	84-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-57
12403162-2	2002	COX-1 and COX-2 activity, measaured as prostaglandin E2 (PGE2) production, were concentration-dependently inhibited by propolis (3 x 10(-3) - 3 x 10(2) microgml(-1)) with an IC50 of 2.7 microgml(-1) and 4.8 x 10(-2) microgml(-1), respectively.	Dinoprostone	39-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
12357401-0	2002	Flavonoids and stilbenoids with COX-1 and COX-2 inhibitory activity from Dracaena loureiri.	Flavonoids	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47
12357401-0	2002	Flavonoids and stilbenoids with COX-1 and COX-2 inhibitory activity from Dracaena loureiri.	stilbenoids	15-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47
12403162-2	2002	COX-1 and COX-2 activity, measaured as prostaglandin E2 (PGE2) production, were concentration-dependently inhibited by propolis (3 x 10(-3) - 3 x 10(2) microgml(-1)) with an IC50 of 2.7 microgml(-1) and 4.8 x 10(-2) microgml(-1), respectively.	Dinoprostone	57-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
12206771-8	2002	Further, the protein binds Zn(II) and Co(II) in the expected manner and shows ferroxidase activity under single turnover conditions.	Zinc	27-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-44
12209034-1	2002	OBJECTIVE: To compare the efficacy of the COX-2 specific inhibitor valdecoxib with the conventional NSAID naproxen and placebo in treating rheumatoid arthritis (RA).	valdecoxib	67-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47
12196951-2	2002	The synthesis of a verdazyl radical with a carboxylate substituent renders the radical highly soluble in water, thereby permitting the aqueous synthesis of Ni(II) and Co(II) verdazyl complexes which have been structurally and magnetically characterized.	verdazyl radical	19-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	167-173
12196951-2	2002	The synthesis of a verdazyl radical with a carboxylate substituent renders the radical highly soluble in water, thereby permitting the aqueous synthesis of Ni(II) and Co(II) verdazyl complexes which have been structurally and magnetically characterized.	carboxylate	43-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	167-173
12196951-2	2002	The synthesis of a verdazyl radical with a carboxylate substituent renders the radical highly soluble in water, thereby permitting the aqueous synthesis of Ni(II) and Co(II) verdazyl complexes which have been structurally and magnetically characterized.	Water	105-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	167-173
12167017-4	2002	The optical absorption spectra of the Co(II) complexes of Ant-F and its derivative proteins suggest that the geometry of the metal center of holo-Ant-F is tetrahedral and that the mutated Cys(2)His(2) residues are involved in the complex formation.	Fluorine	62-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-44
12167017-4	2002	The optical absorption spectra of the Co(II) complexes of Ant-F and its derivative proteins suggest that the geometry of the metal center of holo-Ant-F is tetrahedral and that the mutated Cys(2)His(2) residues are involved in the complex formation.	Metals	125-130	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-44
12167017-4	2002	The optical absorption spectra of the Co(II) complexes of Ant-F and its derivative proteins suggest that the geometry of the metal center of holo-Ant-F is tetrahedral and that the mutated Cys(2)His(2) residues are involved in the complex formation.	Cysteine	188-191	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-44
12167017-4	2002	The optical absorption spectra of the Co(II) complexes of Ant-F and its derivative proteins suggest that the geometry of the metal center of holo-Ant-F is tetrahedral and that the mutated Cys(2)His(2) residues are involved in the complex formation.	Histidine	194-197	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-44
12203329-4	2002	Specifically, the effects that these differences have on the axial ligation properties of the Zn(II), Mg(II), Ni(II), and Co(II) complexes of P, Pc, Cn, and Hpc in toluene using pyridine as the axial ligand are detailed.	Porphyrins	142-143	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-128
12146942-5	2002	In this report, characterization of a set of cysteine substitution mutants of SmtB reveals that SmtB homodimer binds Zn(II) or Co(II) in one of two mutually exclusive metal binding sites, termed alpha3N and alpha5, with very high equilibrium affinities.	Cysteine	45-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	127-133
12146942-5	2002	In this report, characterization of a set of cysteine substitution mutants of SmtB reveals that SmtB homodimer binds Zn(II) or Co(II) in one of two mutually exclusive metal binding sites, termed alpha3N and alpha5, with very high equilibrium affinities.	Metals	167-172	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	127-133
12146942-7	2002	Co(II) bound exclusively at the alpha5 sites is capable of rapid equilibration between the alpha3N and alpha5 sites upon reduction of the mixed disulfides in S-methylated SmtB.	Disulfides	144-154	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
12203329-4	2002	Specifically, the effects that these differences have on the axial ligation properties of the Zn(II), Mg(II), Ni(II), and Co(II) complexes of P, Pc, Cn, and Hpc in toluene using pyridine as the axial ligand are detailed.	porphycene	145-147	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-128
12203329-4	2002	Specifically, the effects that these differences have on the axial ligation properties of the Zn(II), Mg(II), Ni(II), and Co(II) complexes of P, Pc, Cn, and Hpc in toluene using pyridine as the axial ligand are detailed.	Toluene	164-171	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-128
12203329-4	2002	Specifically, the effects that these differences have on the axial ligation properties of the Zn(II), Mg(II), Ni(II), and Co(II) complexes of P, Pc, Cn, and Hpc in toluene using pyridine as the axial ligand are detailed.	pyridine	178-186	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-128
12203329-10	2002	The Zn(II) and Mg(II) complexes were all far less stable than the corresponding Ni(II) and Co(II) complexes.	mg(ii)	15-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-97
12142058-0	2002	Structure-activity relationship of indomethacin analogues for MRP-1, COX-1 and COX-2 inhibition.	Indomethacin	35-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-84
12107070-4	2002	Herein, we demonstrate that the expression, induction, and subcellular localization of COX-1 and COX-2 and the downstream PG biosynthesis are markedly different between these subsets.	Prostaglandins	122-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
12107070-5	2002	Specifically, Thy-1(+) fibroblasts highly express COX-1, which is responsible for high-level PGE(2) production, a feature usually attributed to the COX-2 isoenzyme.	Dinoprostone	93-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	148-153
12107070-6	2002	In contrast, COX-2, generally considered an inducible isoform, is constitutively expressed in the Thy-1(-) subset, which only minimally produces PGE(2).	Prostaglandins E	145-148	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
12162776-4	2002	The inductive effects of proinflammatory cytokines (IL-1alpha or tumor necrosis factor alpha) alone or in combination with prostaglandin E(2) on IL-6 and COX-2 messenger RNA (mRNA) synthesis in NPFs were investigated.	Dinoprostone	123-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	154-159
12162776-8	2002	Meloxicam (a specific COX-2 inhibitor) suppressed the induction of cytokines on IL-6 mRNA levels, and these effects could be reversed by exogenous prostaglandin E(2).	Meloxicam	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-27
12162776-8	2002	Meloxicam (a specific COX-2 inhibitor) suppressed the induction of cytokines on IL-6 mRNA levels, and these effects could be reversed by exogenous prostaglandin E(2).	Prostaglandins E	147-162	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-27
12123780-3	2002	Our present study focused on the mechanisms through which oxidized phospholipids inhibit LPS-induced Cox-2 expression in human macrophages.	Phospholipids	67-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-106
12142058-8	2002	One MRP-1 inhibitory indomethacin analogue was also found to have low COX-1 inhibitory activity, but significant COX-2 inhibitory activity, making this analogue again interesting in terms of low potential toxicity, but with the possibility of direct inhibitory effects on tumour growth.	Indomethacin	21-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-118
12938390-0	2002	[Photometric determination of cobalt by the formation of a multi-ligand complex of Co(II)-C16H16N2S2O2-DEA].	Cobalt	30-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
12067581-4	2002	The bacterial formamidopyrimidine-DNA glycosylase (Fpg protein) involved in base excision repair was inhibited by Cd(II), Cu(II) and Hg(II) with increasing efficiencies, whereas Co(II), As(III), Pb(II) and Ni(II) had no effect.	formamidopyrimidine	14-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	178-184
12067581-7	2002	Regarding the mammalian XPA protein involved in the recognition of DNA lesions during nucleotide excision repair, its DNA-binding capacity was diminished by Cd(II), Cu(II), Ni(II) and Co(II), while Hg(II), Pb(II) and As(III) were ineffective.	pb(ii)	206-212	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	184-190
12067581-7	2002	Regarding the mammalian XPA protein involved in the recognition of DNA lesions during nucleotide excision repair, its DNA-binding capacity was diminished by Cd(II), Cu(II), Ni(II) and Co(II), while Hg(II), Pb(II) and As(III) were ineffective.	as(iii)	217-224	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	184-190
12067581-8	2002	Finally, the H(2)O(2)-induced activation of the poly(ADP-ribose)polymerase (PARP) involved in DNA strand break detection and apoptosis was greatly reduced by Cd(II), Co(II), Ni(II) and As(III).	Hydrogen Peroxide	13-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	166-172
12067581-8	2002	Finally, the H(2)O(2)-induced activation of the poly(ADP-ribose)polymerase (PARP) involved in DNA strand break detection and apoptosis was greatly reduced by Cd(II), Co(II), Ni(II) and As(III).	as(iii)	185-192	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	166-172
12938390-1	2002	The new ligand vanillin S-benzyldithocarbazte(HL) and its complex Co(II)-C16H16N2S2O2-DEA was synthesized and characterized by IR, UV-Vis.	vanillin s-benzyldithocarbazte	15-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-71
12938390-1	2002	The new ligand vanillin S-benzyldithocarbazte(HL) and its complex Co(II)-C16H16N2S2O2-DEA was synthesized and characterized by IR, UV-Vis.	histidylleucine	46-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-71
12162470-2	2002	Meloxicam is a relatively COX-2-selective anti-arthritis drug that shows significant TxA2 inhibition, albeit less than traditional NSAIDs.	Meloxicam	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-31
12198983-6	2002	(The other selective COX-2 inhibitors, celecoxib and valdecoxib, do not carry label indications for short-term management of postoperative pain.)	Celecoxib	39-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-26
12198983-6	2002	(The other selective COX-2 inhibitors, celecoxib and valdecoxib, do not carry label indications for short-term management of postoperative pain.)	valdecoxib	53-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-26
12198983-7	2002	RESULTS: The findings of this literature review show that the COX-2-selective inhibitor rofecoxib is no more effective than conventional, nonselective, nonsteroidal anti-inflammatory drugs, or NSAIDs, for the relief of postoperative dental pain.	rofecoxib	88-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
12153723-2	2002	Activation of the enzyme by Co(II) treatment has been reported using pyridylamino derivatives of Man(5)GlcNAc and Man(5)GlcNAc2, and p-nitrophenyl alpha-mannoside as substrates, with the Co(II)-treated enzyme releasing four alpha-mannose residues from Man(9)GlcNAc to give Manalpha1-6(Manalpha1-2Manalpha1-2Manalpha1-3)Manbeta1-4GlcNAc as an end product.	pyridylamino	69-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-34
12153723-2	2002	Activation of the enzyme by Co(II) treatment has been reported using pyridylamino derivatives of Man(5)GlcNAc and Man(5)GlcNAc2, and p-nitrophenyl alpha-mannoside as substrates, with the Co(II)-treated enzyme releasing four alpha-mannose residues from Man(9)GlcNAc to give Manalpha1-6(Manalpha1-2Manalpha1-2Manalpha1-3)Manbeta1-4GlcNAc as an end product.	pyridylamino	69-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	187-193
12153723-2	2002	Activation of the enzyme by Co(II) treatment has been reported using pyridylamino derivatives of Man(5)GlcNAc and Man(5)GlcNAc2, and p-nitrophenyl alpha-mannoside as substrates, with the Co(II)-treated enzyme releasing four alpha-mannose residues from Man(9)GlcNAc to give Manalpha1-6(Manalpha1-2Manalpha1-2Manalpha1-3)Manbeta1-4GlcNAc as an end product.	4-nitrophenyl-alpha-D-mannopyranoside	133-162	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-34
12153723-2	2002	Activation of the enzyme by Co(II) treatment has been reported using pyridylamino derivatives of Man(5)GlcNAc and Man(5)GlcNAc2, and p-nitrophenyl alpha-mannoside as substrates, with the Co(II)-treated enzyme releasing four alpha-mannose residues from Man(9)GlcNAc to give Manalpha1-6(Manalpha1-2Manalpha1-2Manalpha1-3)Manbeta1-4GlcNAc as an end product.	4-nitrophenyl-alpha-D-mannopyranoside	133-162	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	187-193
12153723-2	2002	Activation of the enzyme by Co(II) treatment has been reported using pyridylamino derivatives of Man(5)GlcNAc and Man(5)GlcNAc2, and p-nitrophenyl alpha-mannoside as substrates, with the Co(II)-treated enzyme releasing four alpha-mannose residues from Man(9)GlcNAc to give Manalpha1-6(Manalpha1-2Manalpha1-2Manalpha1-3)Manbeta1-4GlcNAc as an end product.	alpha-D-Mannose	224-237	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-34
12153723-2	2002	Activation of the enzyme by Co(II) treatment has been reported using pyridylamino derivatives of Man(5)GlcNAc and Man(5)GlcNAc2, and p-nitrophenyl alpha-mannoside as substrates, with the Co(II)-treated enzyme releasing four alpha-mannose residues from Man(9)GlcNAc to give Manalpha1-6(Manalpha1-2Manalpha1-2Manalpha1-3)Manbeta1-4GlcNAc as an end product.	alpha-D-Mannose	224-237	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	187-193
12153723-2	2002	Activation of the enzyme by Co(II) treatment has been reported using pyridylamino derivatives of Man(5)GlcNAc and Man(5)GlcNAc2, and p-nitrophenyl alpha-mannoside as substrates, with the Co(II)-treated enzyme releasing four alpha-mannose residues from Man(9)GlcNAc to give Manalpha1-6(Manalpha1-2Manalpha1-2Manalpha1-3)Manbeta1-4GlcNAc as an end product.	9)glcnac	256-264	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-34
12189249-6	2002	These findings suggest that premature fetal DA closure or neonatal patent DA observed following indomethacin tocolysis in women may result from the inhibition of COX-2.	Indomethacin	96-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	162-167
12153723-2	2002	Activation of the enzyme by Co(II) treatment has been reported using pyridylamino derivatives of Man(5)GlcNAc and Man(5)GlcNAc2, and p-nitrophenyl alpha-mannoside as substrates, with the Co(II)-treated enzyme releasing four alpha-mannose residues from Man(9)GlcNAc to give Manalpha1-6(Manalpha1-2Manalpha1-2Manalpha1-3)Manbeta1-4GlcNAc as an end product.	9)glcnac	256-264	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	187-193
12153723-2	2002	Activation of the enzyme by Co(II) treatment has been reported using pyridylamino derivatives of Man(5)GlcNAc and Man(5)GlcNAc2, and p-nitrophenyl alpha-mannoside as substrates, with the Co(II)-treated enzyme releasing four alpha-mannose residues from Man(9)GlcNAc to give Manalpha1-6(Manalpha1-2Manalpha1-2Manalpha1-3)Manbeta1-4GlcNAc as an end product.	4-O-beta-D-mannopyranosyl-N-acetyl-D-glucosamine	319-335	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-34
12153723-2	2002	Activation of the enzyme by Co(II) treatment has been reported using pyridylamino derivatives of Man(5)GlcNAc and Man(5)GlcNAc2, and p-nitrophenyl alpha-mannoside as substrates, with the Co(II)-treated enzyme releasing four alpha-mannose residues from Man(9)GlcNAc to give Manalpha1-6(Manalpha1-2Manalpha1-2Manalpha1-3)Manbeta1-4GlcNAc as an end product.	4-O-beta-D-mannopyranosyl-N-acetyl-D-glucosamine	319-335	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	187-193
12153723-3	2002	When Man(9)GlcNAc, which is considered to be the actual substrate in the cytosol, was used as a substrate, we found that even before treatment with Co(II) the enzyme was able to cleave a single Manalpha1-2 residue from Man(9)GlcNAc to give Manalpha1-6(Manalpha1-2Manalpha1-3)Manalpha1-6(Manalpha1-2Manalpha1-2Manalpha1-3)Manbeta1-4GlcNAc as the end product.	-4glcnac	329-337	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	148-153
12225656-2	2002	This study was designed to investigate the relationship between NOC/oFQ, another opioid, dynorphin, and activation of the COX-2 isoform of the enzyme in such impaired dilation to NMDA after FPI in piglets equipped with a closed cranial window.	N-Methylaspartate	179-183	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-127
12225656-0	2002	Relationship between NOC/oFQ, dynorphin, and COX-2 activation in impaired NMDA cerebrovasodilation after brain injury.	N-Methylaspartate	74-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-50
12502903-4	2002	We hypothesized that PGE2 production by activated macrophages is dependent upon the induction of COX-2, not upon the constitutive isozyme, COX-1.	Dinoprostone	21-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
12502903-5	2002	When we evaluated the expression of COX-1 and COX-2 in titanium-alloy particle-stimulated human macrophages, the expression of COX-2 mRNA was up-regulated by the particles, on the other hand, the expression of COX-1 mRNA was not affected.	Titanium	55-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
12502903-5	2002	When we evaluated the expression of COX-1 and COX-2 in titanium-alloy particle-stimulated human macrophages, the expression of COX-2 mRNA was up-regulated by the particles, on the other hand, the expression of COX-1 mRNA was not affected.	Titanium	55-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	127-132
12502903-5	2002	When we evaluated the expression of COX-1 and COX-2 in titanium-alloy particle-stimulated human macrophages, the expression of COX-2 mRNA was up-regulated by the particles, on the other hand, the expression of COX-1 mRNA was not affected.	Alloys	64-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
12502903-5	2002	When we evaluated the expression of COX-1 and COX-2 in titanium-alloy particle-stimulated human macrophages, the expression of COX-2 mRNA was up-regulated by the particles, on the other hand, the expression of COX-1 mRNA was not affected.	Alloys	64-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	127-132
12502903-6	2002	In addition, NS-398, a COX-2 inhibitor drastically suppressed up-regulated PGE2 production by the particles.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	13-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-28
12502903-6	2002	In addition, NS-398, a COX-2 inhibitor drastically suppressed up-regulated PGE2 production by the particles.	Dinoprostone	75-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-28
12502903-7	2002	These results provide strong evidence that PGE2 production by particle-stimulated macrophages is dependent upon the induction of COX-2, not COX-1.	Dinoprostone	43-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-134
12432912-8	2002	The induction of COX-2 is suppressed by dexamethasone and PGJ2.	Dexamethasone	40-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22
12432912-8	2002	The induction of COX-2 is suppressed by dexamethasone and PGJ2.	9-deoxy-delta-9-prostaglandin D2	58-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22
12195707-7	2002	These results demonstrate that regulation of COX-2 induction is an important functional response of HUVEC to PAR activation and suggest that PARs promote sustained upregulation of prostanoid production in human endothelium.	4-(2-pyridylazo)resorcinol	109-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-50
12195707-7	2002	These results demonstrate that regulation of COX-2 induction is an important functional response of HUVEC to PAR activation and suggest that PARs promote sustained upregulation of prostanoid production in human endothelium.	Prostaglandins	180-190	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-50
12703120-3	2002	Two NSAIDs (celecoxib and rofecoxib) COX-2 specific inhibitors had considerably lower ulcerogenic rates and lower serious gastro-intestinal side effects when compared with other NSAIDs used in rheumatoid arthritis and osteoarthritis.	Celecoxib	12-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-42
12703120-3	2002	Two NSAIDs (celecoxib and rofecoxib) COX-2 specific inhibitors had considerably lower ulcerogenic rates and lower serious gastro-intestinal side effects when compared with other NSAIDs used in rheumatoid arthritis and osteoarthritis.	rofecoxib	26-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-42
12093511-0	2002	Electrochemical analysis of sparfloxacin in pharmaceutical formulation and biochemical screening of its Co(II) complex.	sparfloxacin	28-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-110
12093511-4	2002	Sparfloxacin forms a complex with Co(II) which has been characterized on the basis of elemental analysis, IR spectral, polarographic and amperometric analysis.	sparfloxacin	0-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-40
12121793-1	2002	In this work we present the synthesis and structural and spectroscopic characterization of Cu(II), Co(II) and Zn(II) coordination compounds with the antibiotic metronidazole ([double bond]emni).	Metronidazole	160-173	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-105
12121793-1	2002	In this work we present the synthesis and structural and spectroscopic characterization of Cu(II), Co(II) and Zn(II) coordination compounds with the antibiotic metronidazole ([double bond]emni).	emni	188-192	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-105
12006564-9	2002	Intriguingly, we found that PGE(2) was one of the major factors in MECM, which was responsible for up-regulating COX-2 expression in ESC.	Prostaglandins E	28-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-118
12006564-11	2002	In conclusion, malignant endometrial epithelial cells secrete PGE(2) that induces COX-2 expression in normal endometrial stromal cells in a paracrine fashion through activation of transcription and stabilization of COX-2 mRNA.	Prostaglandins E	62-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
12006564-11	2002	In conclusion, malignant endometrial epithelial cells secrete PGE(2) that induces COX-2 expression in normal endometrial stromal cells in a paracrine fashion through activation of transcription and stabilization of COX-2 mRNA.	Prostaglandins E	62-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	215-220
12105923-8	2002	Texaphyrin complexes of Mn(II), Co(II), and Fe(III) in particular may possess sufficient aqueous stability to permit their use in pharmaceutical applications.	texaphyrin	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-37
12099873-5	2002	In particular, the electronic charge-transfer and d-d bands of the Co(II)-substituted peptide complexes were used to examine the metal coordination number and geometry.	Metals	129-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-72
12100758-0	2002	JTE-522, a selective COX-2 inhibitor, inhibits cell proliferation and induces apoptosis in RL95-2 cells.	4-(4-cyclohexyl-2-methyloxazol-5-yl)-2-fluorobenzenesulfonamide	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-26
12100758-1	2002	AIM: To investigate whether JTE-522 [4-(4-cyclohexyl-2-methyloxazol-5-yl)-2-fluorobenzenesulfonamide], a selective COX-2 inhibitor, can induce apoptosis and inhibit cell proliferation in human endometrial cancer cell line RL95-2 cells and to explore the molecular mechanisms.	4-(4-cyclohexyl-2-methyloxazol-5-yl)-2-fluorobenzenesulfonamide	28-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-120
12100758-1	2002	AIM: To investigate whether JTE-522 [4-(4-cyclohexyl-2-methyloxazol-5-yl)-2-fluorobenzenesulfonamide], a selective COX-2 inhibitor, can induce apoptosis and inhibit cell proliferation in human endometrial cancer cell line RL95-2 cells and to explore the molecular mechanisms.	4-(4-cyclohexyl-2-methyloxazol-5-yl)-2-fluorobenzenesulfonamide	37-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-120
12060588-2	2002	It is hypothesized that in response to acute inhibition of NOS, the influence of COX-2-derived prostanoids is exaggerated, compensating for renal vasoconstriction.	Prostaglandins	95-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-86
12060588-8	2002	The constrictor response to COX-2 inhibition after L-NAME could not be duplicated by either selective nNOS inhibition or NOS-independent renal vasoconstriction.	NG-Nitroarginine Methyl Ester	51-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
12060588-9	2002	Acute NOS inhibition unmasked renal vasoconstriction with COX-2 inhibition, suggesting that the influence of COX-2-derived vasodilator eicosanoids is exaggerated to maintain renal perfusion, compensating for the acute loss of NO.	Eicosanoids	135-146	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
12060588-9	2002	Acute NOS inhibition unmasked renal vasoconstriction with COX-2 inhibition, suggesting that the influence of COX-2-derived vasodilator eicosanoids is exaggerated to maintain renal perfusion, compensating for the acute loss of NO.	Eicosanoids	135-146	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-114
12110979-3	2002	The concentrations of amitrole in 0.1 M NaOH solutions were determined using the electrocatalytic oxidation signal corresponding to the Co(II)/Co(III) redox process.	Amitrole	22-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	136-142
12110979-3	2002	The concentrations of amitrole in 0.1 M NaOH solutions were determined using the electrocatalytic oxidation signal corresponding to the Co(II)/Co(III) redox process.	Sodium Hydroxide	40-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	136-142
12322896-12	2002	CONCLUSION: Hyper activation of COX-2 with abnormal prostaglandin generation is considered to contribute to the pathophysiology of endometriosis and disease progression.	Prostaglandins	52-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-37
12199620-4	2002	Two COX isoforms have been identified, COX-1 and COX-2 that form PGH2, a common precursor for the biosynthesis of thromboxane A2 (TxA2), prostacyclin (PGI2) and PGs (PGD2, PGE2, PGF2alpha.	Prostaglandin H2	65-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-54
12199620-4	2002	Two COX isoforms have been identified, COX-1 and COX-2 that form PGH2, a common precursor for the biosynthesis of thromboxane A2 (TxA2), prostacyclin (PGI2) and PGs (PGD2, PGE2, PGF2alpha.	Thromboxane A2	114-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-54
12199620-4	2002	Two COX isoforms have been identified, COX-1 and COX-2 that form PGH2, a common precursor for the biosynthesis of thromboxane A2 (TxA2), prostacyclin (PGI2) and PGs (PGD2, PGE2, PGF2alpha.	Thromboxane A2	130-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-54
12199620-4	2002	Two COX isoforms have been identified, COX-1 and COX-2 that form PGH2, a common precursor for the biosynthesis of thromboxane A2 (TxA2), prostacyclin (PGI2) and PGs (PGD2, PGE2, PGF2alpha.	Epoprostenol	137-149	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-54
12199620-4	2002	Two COX isoforms have been identified, COX-1 and COX-2 that form PGH2, a common precursor for the biosynthesis of thromboxane A2 (TxA2), prostacyclin (PGI2) and PGs (PGD2, PGE2, PGF2alpha.	Epoprostenol	151-155	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-54
12199620-4	2002	Two COX isoforms have been identified, COX-1 and COX-2 that form PGH2, a common precursor for the biosynthesis of thromboxane A2 (TxA2), prostacyclin (PGI2) and PGs (PGD2, PGE2, PGF2alpha.	Prostaglandins	161-164	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-54
12199620-4	2002	Two COX isoforms have been identified, COX-1 and COX-2 that form PGH2, a common precursor for the biosynthesis of thromboxane A2 (TxA2), prostacyclin (PGI2) and PGs (PGD2, PGE2, PGF2alpha.	Dinoprostone	172-176	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-54
12199620-4	2002	Two COX isoforms have been identified, COX-1 and COX-2 that form PGH2, a common precursor for the biosynthesis of thromboxane A2 (TxA2), prostacyclin (PGI2) and PGs (PGD2, PGE2, PGF2alpha.	Dinoprost	178-187	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-54
12199620-8	2002	COX-2 is normally absent from most cells but highly inducible in certain cells in response to inflammatory stimuli resulting in enhanced PG release.	Prostaglandins	137-139	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
12110440-9	2002	PGE(2) synthesis appeared to be via COX-2.	Dinoprostone	0-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-41
12114451-1	2002	This study reports that a selective COX-2 inhibitor JTE-522inhibits both in vitro and in vivo growth of human lung cancer cells as a single agent.	jte-522inhibits	52-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-41
12141411-4	2002	Rofecoxib, a specific COX 2 inhibitor, promptly elevated serum potassium concentration with normalization of plasma aldosterone and near normalization of renin without a change in serum magnesium.	rofecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-27
12141411-4	2002	Rofecoxib, a specific COX 2 inhibitor, promptly elevated serum potassium concentration with normalization of plasma aldosterone and near normalization of renin without a change in serum magnesium.	Potassium	63-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-27
12152003-8	2002	A similar relationship was observed for the suppression of prostaglandin E(2) (a product of both isoforms) at time points consistent with COX-2 expression (P &lt;.001).	Dinoprostone	59-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	138-143
12152003-10	2002	CONCLUSIONS: The suppression of products of COX-2 coincident with pain suppression and the absence of COX-1 inhibition suggest that celecoxib is a relatively selective COX-2 inhibitor in vivo.	Celecoxib	132-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-49
12152003-10	2002	CONCLUSIONS: The suppression of products of COX-2 coincident with pain suppression and the absence of COX-1 inhibition suggest that celecoxib is a relatively selective COX-2 inhibitor in vivo.	Celecoxib	132-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	168-173
12126777-3	2002	Compounds 6-11 were tested in vitro for their inhibitory activity towards COX-1 and COX-2 by measuring prostaglandin E2 (PGE2) production in U937 cell lines and activated J774.2 macrophages, respectively.	compounds	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-89
12076714-10	2002	Significant correlation was observed between the relative amount of COX(2) and hyaluronan (P&lt;0.01).	Hyaluronic Acid	79-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-74
12079454-0	2002	Synthesis and structural and spectroscopic characterization of a complex between Co(II) and imino-bis(methylphosphonic acid): gaining insight into biologically relevant metal-ion phosphonate interactions or looking at a new Co(II)-organophosphonate material?	(phosphonomethylamino)methylphosphonic acid	92-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-87
12079454-0	2002	Synthesis and structural and spectroscopic characterization of a complex between Co(II) and imino-bis(methylphosphonic acid): gaining insight into biologically relevant metal-ion phosphonate interactions or looking at a new Co(II)-organophosphonate material?	(phosphonomethylamino)methylphosphonic acid	92-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	224-230
12079454-0	2002	Synthesis and structural and spectroscopic characterization of a complex between Co(II) and imino-bis(methylphosphonic acid): gaining insight into biologically relevant metal-ion phosphonate interactions or looking at a new Co(II)-organophosphonate material?	Metals	169-174	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-87
12079454-0	2002	Synthesis and structural and spectroscopic characterization of a complex between Co(II) and imino-bis(methylphosphonic acid): gaining insight into biologically relevant metal-ion phosphonate interactions or looking at a new Co(II)-organophosphonate material?	Organophosphonates	179-190	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-87
12079454-2	2002	As a metal ion, Co(II) assumes forms, which are dictated by the nature of organic binders in biological fluids, and the conditions under which metal ion ligand interactions arise.	Metals	5-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-22
12079454-2	2002	As a metal ion, Co(II) assumes forms, which are dictated by the nature of organic binders in biological fluids, and the conditions under which metal ion ligand interactions arise.	Metals	143-148	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-22
12079454-4	2002	As a representative metal ion binder, the organophosphonate ligand H(2)O(3)P-CH(2)-NH(2)(+)-CH(2)-PO(3)H(-) was employed in aqueous reactions with Co(II), ultimately leading to the isolation of complex [Co(C(2)H(8)O(6)NP(2))(2)(H(2)O)(2)] (1) at pH 2.	Metals	20-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-153
12079454-4	2002	As a representative metal ion binder, the organophosphonate ligand H(2)O(3)P-CH(2)-NH(2)(+)-CH(2)-PO(3)H(-) was employed in aqueous reactions with Co(II), ultimately leading to the isolation of complex [Co(C(2)H(8)O(6)NP(2))(2)(H(2)O)(2)] (1) at pH 2.	Organophosphonates	42-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-153
12079454-4	2002	As a representative metal ion binder, the organophosphonate ligand H(2)O(3)P-CH(2)-NH(2)(+)-CH(2)-PO(3)H(-) was employed in aqueous reactions with Co(II), ultimately leading to the isolation of complex [Co(C(2)H(8)O(6)NP(2))(2)(H(2)O)(2)] (1) at pH 2.	nh(2)(+)	83-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-153
12079454-4	2002	As a representative metal ion binder, the organophosphonate ligand H(2)O(3)P-CH(2)-NH(2)(+)-CH(2)-PO(3)H(-) was employed in aqueous reactions with Co(II), ultimately leading to the isolation of complex [Co(C(2)H(8)O(6)NP(2))(2)(H(2)O)(2)] (1) at pH 2.	(2)-po(3)h(-)	94-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-153
12079454-8	2002	In it, there exist mononuclear octahedral sites of Co(II) surrounded by oxygens, belonging to terminal phosphonates and bound water molecules.	Oxygen	72-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-57
12079454-8	2002	In it, there exist mononuclear octahedral sites of Co(II) surrounded by oxygens, belonging to terminal phosphonates and bound water molecules.	Organophosphonates	103-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-57
12079454-8	2002	In it, there exist mononuclear octahedral sites of Co(II) surrounded by oxygens, belonging to terminal phosphonates and bound water molecules.	Water	126-131	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-57
12079454-11	2002	The magnetic and EPR data on 1 support the presence of a high-spin octahedral Co(II) in an oxygen environment, having a ground state with an effective spin S = (1)/(2).	Oxygen	91-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-84
12079454-14	2002	Both biologically relevant perspectives and a synthetic outlook into Co(II)-organophosphonate materials are discussed.	Organophosphonates	76-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-75
12096032-5	2002	PD98059 (MEK1 inhibitor) and SB203580 (p38(MAPK) inhibitor) reduced PGE(2) production as well as COX-2 expression in LPS-stimulated neutrophils.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
12096032-5	2002	PD98059 (MEK1 inhibitor) and SB203580 (p38(MAPK) inhibitor) reduced PGE(2) production as well as COX-2 expression in LPS-stimulated neutrophils.	SB 203580	29-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
12096032-10	2002	Taken together, these results suggest that both ERK and p38(MAPK) pathways are involved in LPS-induced COX-2 expression and PGE(2) production in neutrophils, and IL-10 and IL-4 inhibit neutrophil prostanoid synthesis by down-regulating the activation of p38(MAPK).	Prostaglandins	196-206	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-108
12166615-1	2002	We previously found that the cyclooxygenase (COX)-2 preferential inhibitor nimesulide protects rodents" chondrocytes against apoptotic death in vitro.	nimesulide	75-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-51
12148806-4	2002	The kinetics and thermodynamics of acetonitrile addition to the metal complex ions are strongly affected by the chemical environment around the metal center such that significant differences in reactivity are observed for Co(II) and Cu(II) complexes with various coordination spheres.	acetonitrile	35-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	222-228
12148806-4	2002	The kinetics and thermodynamics of acetonitrile addition to the metal complex ions are strongly affected by the chemical environment around the metal center such that significant differences in reactivity are observed for Co(II) and Cu(II) complexes with various coordination spheres.	Metals	64-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	222-228
12148806-4	2002	The kinetics and thermodynamics of acetonitrile addition to the metal complex ions are strongly affected by the chemical environment around the metal center such that significant differences in reactivity are observed for Co(II) and Cu(II) complexes with various coordination spheres.	Metals	144-149	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	222-228
14613417-9	2002	Female gender, chronic steroid use, and age each increased the odds of receiving a Cox-2 selective NSAID by about 35% (P&lt;0.001 for all).	Steroids	23-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
12204486-7	2002	Recent studies have demonstrated that the COX-2 inhibitor rofecoxib significantly improves quality of life in patients with osteoarthritis and chronic, lower back pain.	rofecoxib	58-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47
12105234-0	2002	Strategies to safely interfere with prostanoid activity while avoiding adverse renal effects: could COX-2 and COX-LOX dual inhibition be the answer?	Prostaglandins	36-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-105
12096231-8	2002	Celecoxib, by diminishing COX-2 activity, prevents these adverse effects without having a direct effect on healthy cartilage.	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-31
11927585-2	2002	To determine the mechanism by which COX2 activity promotes RMIC viability, we examined the capacity of COX2-derived prostanoids to promote RMIC survival.	Prostaglandins	116-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-107
11927585-6	2002	Conversely DRE activity was only inhibited by the COX2-selective inhibitor SC236 but not by a COX1-selective NSAID (SC560).	4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide	75-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-54
11927585-8	2002	These studies are consistent with a model whereby hypertonicity activates COX2-derived prostaglandin production, which promotes RMIC viability through PPARdelta.	Prostaglandins	87-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-78
12016133-3	2002	Carbachol was the most potent inducer of COX-2 gene expression.	Carbachol	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-46
12016133-8	2002	Addition of SB-203580 with Ad.dom.neg.IkappaB almost completely blocked carbachol stimulation of COX-2 gene expression.	SB 203580	12-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
12016133-8	2002	Addition of SB-203580 with Ad.dom.neg.IkappaB almost completely blocked carbachol stimulation of COX-2 gene expression.	Carbachol	72-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
12016133-12	2002	Selective COX-2 inhibitor NS-398 blocked carbachol-stimulated PGE(2) release without affecting basal PGE(2) production.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	26-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
12016133-12	2002	Selective COX-2 inhibitor NS-398 blocked carbachol-stimulated PGE(2) release without affecting basal PGE(2) production.	Carbachol	41-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
12016133-12	2002	Selective COX-2 inhibitor NS-398 blocked carbachol-stimulated PGE(2) release without affecting basal PGE(2) production.	Dinoprostone	62-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
12016133-14	2002	Carbachol induces COX-2 gene expression in the parietal cells through signaling pathways that involve intracellular Ca(2+), PKC, p38 kinase, and activation of NF-kappaB.	Carbachol	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-23
12102331-0	2002	Sorption and desorption of Co(II) on alumina: mechanisms and effect of humic substances.	Aluminum Oxide	37-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-33
12102331-0	2002	Sorption and desorption of Co(II) on alumina: mechanisms and effect of humic substances.	Humic Substances	71-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-33
12102331-1	2002	The effects of pH, ionic strength and humic substances on the sorption and desorption of Co(II) on alumina and silica were, respectively investigated by using radiotracer 60Co.	Humic Substances	38-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-95
12102331-1	2002	The effects of pH, ionic strength and humic substances on the sorption and desorption of Co(II) on alumina and silica were, respectively investigated by using radiotracer 60Co.	Aluminum Oxide	99-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-95
12102331-1	2002	The effects of pH, ionic strength and humic substances on the sorption and desorption of Co(II) on alumina and silica were, respectively investigated by using radiotracer 60Co.	Silicon Dioxide	111-117	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-95
12102331-3	2002	The pH and the humic substances influenced the sorption of Co(II) on alumina greatly as compared with the sorption of Co(II) on silica.	Aluminum Oxide	69-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
12102331-3	2002	The pH and the humic substances influenced the sorption of Co(II) on alumina greatly as compared with the sorption of Co(II) on silica.	Silicon Dioxide	128-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-124
12102331-4	2002	It was found that the sorption characteristics of Co(II) onto alumina and silica are distinctly different, that the strong chemical bonds are formed between the bare alumina surface and Co(II) and between the coated alumina surface and Co(II), and that a transition from the adsorption to the surface-induced precipitation of Co(II) on the bare alumina surface takes place.	Aluminum Oxide	62-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-56
12102331-4	2002	It was found that the sorption characteristics of Co(II) onto alumina and silica are distinctly different, that the strong chemical bonds are formed between the bare alumina surface and Co(II) and between the coated alumina surface and Co(II), and that a transition from the adsorption to the surface-induced precipitation of Co(II) on the bare alumina surface takes place.	Aluminum Oxide	62-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-55
12065343-3	2002	The discoveries that cyclooxygenase (COX)-2 is an inducible form of COX that is involved in inflammation and that COX-1 is the major isoform responsible for the production of prostaglandins have provided a reasonable basis for the development of specific COX-2 inhibitors as a new class of anti-inflammatory agents.	Prostaglandins	175-189	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	255-260
12065343-4	2002	OBJECTIVE: The purpose of this study was to demonstrate that rofecoxib, a specific inhibitor of COX-2, does not cause asthmatic attacks in patients with ASA and/or other NSAID-induced asthma.	rofecoxib	61-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-101
12031964-0	2002	Inhibition of interleukin-1beta-induced COX-2 and EP3 gene expression by sodium salicylate enhances pancreatic islet beta-cell function.	Sodium Salicylate	73-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
12050227-1	2002	Phospholipase A(2) (PLA(2)) and cyclooxygenase (COX) are two key enzymes in PG synthesis; the latter has two forms, COX-1 and COX-2.	pg	76-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-131
12050227-6	2002	In conclusion, PLA(2), COX-1, and COX-2 are expressed during early human embryonic development and may contribute to the production of PGs such as PGE(2) in human embryogenesis.	Prostaglandins E	147-150	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-39
12037188-6	2002	Our results indicate that COX-2-generated PGE2 regulates membrane excitability and long-term synaptic plasticity in hippocampal perforant path-dentate gyrus synapses.	Dinoprostone	42-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-31
12070756-7	2002	The inhibition of PGE(2) synthesis was confirmed by the in vitro test on purified COX enzymes, showing the selectivity of prodelphinidins on COX-2.	Dinoprostone	18-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	141-146
12070756-7	2002	The inhibition of PGE(2) synthesis was confirmed by the in vitro test on purified COX enzymes, showing the selectivity of prodelphinidins on COX-2.	prodelphinidins	122-137	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	141-146
12233875-2	2002	We investigated mPGES as well as cyclooxygenase (COX)-2, catalyzing arachidonic acid to PGH2, in synovial cells from patients with rheumatoid arthritis (RA).	Prostaglandin H2	88-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-55
12233875-10	2002	Increased conversion of arachidonic acid to PGE2 was maintained when mPGES and COX-2 were coexpressed.	Arachidonic Acid	24-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-84
12233875-10	2002	Increased conversion of arachidonic acid to PGE2 was maintained when mPGES and COX-2 were coexpressed.	Dinoprostone	44-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-84
12233875-13	2002	CONCLUSION: The results suggest that abundant PGE2 production at inflammation sites such as rheumatoid synovia is caused by the coordinated upregulation of mPGES and COX-2.	Dinoprostone	46-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	166-171
12220285-5	2002	Rofecoxib is a selective COX-2 inhibitor that has been shown to increase sodium reabsorption in the kidney via effects on prostaglandin E2 and the renal vasculature.	rofecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-30
12220285-5	2002	Rofecoxib is a selective COX-2 inhibitor that has been shown to increase sodium reabsorption in the kidney via effects on prostaglandin E2 and the renal vasculature.	Sodium	73-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-30
12220285-5	2002	Rofecoxib is a selective COX-2 inhibitor that has been shown to increase sodium reabsorption in the kidney via effects on prostaglandin E2 and the renal vasculature.	Dinoprostone	122-138	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-30
12227215-1	2002	Valdecoxib is a selective COX-2 inhibitor that is similar in anti-inflammatory activity to the other selective COX-2 inhibitors (e.g., celecoxib and rofecoxib).	valdecoxib	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-31
12126328-1	2002	Safety concerns about COX-2 inhibitors rofecoxib (Vioxx) and celecoxib (Celebrex).	rofecoxib	39-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-27
12126328-1	2002	Safety concerns about COX-2 inhibitors rofecoxib (Vioxx) and celecoxib (Celebrex).	rofecoxib	50-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-27
12126328-1	2002	Safety concerns about COX-2 inhibitors rofecoxib (Vioxx) and celecoxib (Celebrex).	Celecoxib	72-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-27
12047181-7	2002	Binding constants in toluene solution increase in the order Fe(II) &lt; Pd(II) &lt; Zn(II) &lt; Mn(II) &lt; Co(II) &lt; Cu(II) &lt; 2H and span the range 490-5200 M-1.	Toluene	21-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-114
12047181-7	2002	Binding constants in toluene solution increase in the order Fe(II) &lt; Pd(II) &lt; Zn(II) &lt; Mn(II) &lt; Co(II) &lt; Cu(II) &lt; 2H and span the range 490-5200 M-1.	ammonium ferrous sulfate	60-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-114
12047181-7	2002	Binding constants in toluene solution increase in the order Fe(II) &lt; Pd(II) &lt; Zn(II) &lt; Mn(II) &lt; Co(II) &lt; Cu(II) &lt; 2H and span the range 490-5200 M-1.	Polydioxanone	72-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-114
12047181-7	2002	Binding constants in toluene solution increase in the order Fe(II) &lt; Pd(II) &lt; Zn(II) &lt; Mn(II) &lt; Co(II) &lt; Cu(II) &lt; 2H and span the range 490-5200 M-1.	Zinc	84-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-114
12047181-7	2002	Binding constants in toluene solution increase in the order Fe(II) &lt; Pd(II) &lt; Zn(II) &lt; Mn(II) &lt; Co(II) &lt; Cu(II) &lt; 2H and span the range 490-5200 M-1.	Manganese(2+)	96-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-114
12047181-7	2002	Binding constants in toluene solution increase in the order Fe(II) &lt; Pd(II) &lt; Zn(II) &lt; Mn(II) &lt; Co(II) &lt; Cu(II) &lt; 2H and span the range 490-5200 M-1.	cu(ii)	120-126	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-114
12047181-7	2002	Binding constants in toluene solution increase in the order Fe(II) &lt; Pd(II) &lt; Zn(II) &lt; Mn(II) &lt; Co(II) &lt; Cu(II) &lt; 2H and span the range 490-5200 M-1.	Deuterium	132-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-114
12082761-11	2002	If paracetamol is insufficient to achieve pain control or inflammation is present, COX-2 specific inhibitors should be considered.	Acetaminophen	3-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
12067908-6	2002	However, selective inhibition of COX-2, but not COX-1, blocked PGI2 production under low cholesterol conditions.	Epoprostenol	63-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-38
12067908-6	2002	However, selective inhibition of COX-2, but not COX-1, blocked PGI2 production under low cholesterol conditions.	Cholesterol	89-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-38
12067908-7	2002	Addition of exogenous cholesterol induces dose-dependent reductions in endothelial COX-2 expression as measured by reverse transcription-polymerase chain reaction and by Western blotting.	Cholesterol	22-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
12067908-8	2002	Pretreatment of cells with actinomycin D, a transcription inhibitor, reduced COX-2-derived PGI2 production by 45.9% (from 0.55+/-0.09 to 0.25+/-0.08 ng/mL).	Dactinomycin	27-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-82
12067908-8	2002	Pretreatment of cells with actinomycin D, a transcription inhibitor, reduced COX-2-derived PGI2 production by 45.9% (from 0.55+/-0.09 to 0.25+/-0.08 ng/mL).	Epoprostenol	91-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-82
12067908-9	2002	Taken together, these observations indicate that endothelial PGI2 production is regulated by cholesterol at the transcriptional level and that cholesterol-sensitive transcriptional pathways that regulate COX-2 expression are present in vascular tissue.	Cholesterol	143-154	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	204-209
12102331-4	2002	It was found that the sorption characteristics of Co(II) onto alumina and silica are distinctly different, that the strong chemical bonds are formed between the bare alumina surface and Co(II) and between the coated alumina surface and Co(II), and that a transition from the adsorption to the surface-induced precipitation of Co(II) on the bare alumina surface takes place.	Aluminum Oxide	166-173	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-56
12102331-4	2002	It was found that the sorption characteristics of Co(II) onto alumina and silica are distinctly different, that the strong chemical bonds are formed between the bare alumina surface and Co(II) and between the coated alumina surface and Co(II), and that a transition from the adsorption to the surface-induced precipitation of Co(II) on the bare alumina surface takes place.	Aluminum Oxide	166-173	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	186-192
12102331-4	2002	It was found that the sorption characteristics of Co(II) onto alumina and silica are distinctly different, that the strong chemical bonds are formed between the bare alumina surface and Co(II) and between the coated alumina surface and Co(II), and that a transition from the adsorption to the surface-induced precipitation of Co(II) on the bare alumina surface takes place.	Aluminum Oxide	166-173	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-55
12102331-4	2002	It was found that the sorption characteristics of Co(II) onto alumina and silica are distinctly different, that the strong chemical bonds are formed between the bare alumina surface and Co(II) and between the coated alumina surface and Co(II), and that a transition from the adsorption to the surface-induced precipitation of Co(II) on the bare alumina surface takes place.	Aluminum Oxide	166-173	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	186-192
12102331-4	2002	It was found that the sorption characteristics of Co(II) onto alumina and silica are distinctly different, that the strong chemical bonds are formed between the bare alumina surface and Co(II) and between the coated alumina surface and Co(II), and that a transition from the adsorption to the surface-induced precipitation of Co(II) on the bare alumina surface takes place.	Aluminum Oxide	166-173	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-56
12102331-4	2002	It was found that the sorption characteristics of Co(II) onto alumina and silica are distinctly different, that the strong chemical bonds are formed between the bare alumina surface and Co(II) and between the coated alumina surface and Co(II), and that a transition from the adsorption to the surface-induced precipitation of Co(II) on the bare alumina surface takes place.	Aluminum Oxide	166-173	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	186-192
12102331-4	2002	It was found that the sorption characteristics of Co(II) onto alumina and silica are distinctly different, that the strong chemical bonds are formed between the bare alumina surface and Co(II) and between the coated alumina surface and Co(II), and that a transition from the adsorption to the surface-induced precipitation of Co(II) on the bare alumina surface takes place.	Aluminum Oxide	166-173	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-55
12102331-4	2002	It was found that the sorption characteristics of Co(II) onto alumina and silica are distinctly different, that the strong chemical bonds are formed between the bare alumina surface and Co(II) and between the coated alumina surface and Co(II), and that a transition from the adsorption to the surface-induced precipitation of Co(II) on the bare alumina surface takes place.	Aluminum Oxide	166-173	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	186-192
12102331-4	2002	It was found that the sorption characteristics of Co(II) onto alumina and silica are distinctly different, that the strong chemical bonds are formed between the bare alumina surface and Co(II) and between the coated alumina surface and Co(II), and that a transition from the adsorption to the surface-induced precipitation of Co(II) on the bare alumina surface takes place.	Aluminum Oxide	166-173	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-56
12102331-4	2002	It was found that the sorption characteristics of Co(II) onto alumina and silica are distinctly different, that the strong chemical bonds are formed between the bare alumina surface and Co(II) and between the coated alumina surface and Co(II), and that a transition from the adsorption to the surface-induced precipitation of Co(II) on the bare alumina surface takes place.	Aluminum Oxide	166-173	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	186-192
12102331-4	2002	It was found that the sorption characteristics of Co(II) onto alumina and silica are distinctly different, that the strong chemical bonds are formed between the bare alumina surface and Co(II) and between the coated alumina surface and Co(II), and that a transition from the adsorption to the surface-induced precipitation of Co(II) on the bare alumina surface takes place.	Aluminum Oxide	166-173	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-55
12102331-4	2002	It was found that the sorption characteristics of Co(II) onto alumina and silica are distinctly different, that the strong chemical bonds are formed between the bare alumina surface and Co(II) and between the coated alumina surface and Co(II), and that a transition from the adsorption to the surface-induced precipitation of Co(II) on the bare alumina surface takes place.	Aluminum Oxide	166-173	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	186-192
12055134-4	2002	Pretreatment of the cells with the sGC inhibitor (ODQ), the protein kinase G (PKG) inhibitor (KT-5823), and the PKC inhibitors (Go 6976 and GF10923X), attenuated the YC-1-induced increase in COX activity and COX-2 expression.	gf10923x	140-148	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	208-213
12055134-9	2002	The MEK inhibitor, PD 98059 (10 - 50 microM), concentration-dependently attenuated the YC-1-induced increases in COX activity and COX-2 expression.	3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole	87-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	130-135
12031964-8	2002	These findings indicate that the sites of action through which sodium salicylate inhibits these negative effects of IL-1beta on beta-cell function include activation of NF-kappaB as well as generation of PGE(2) by COX-2.	Sodium Salicylate	63-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	214-219
12037025-1	2002	AIMS: Cyclo-oxygenases 1 and 2 (COX-1 and COX-2) are key enzymes in prostaglandin biosynthesis.	Prostaglandins	68-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47
12113550-5	2002	Because elevation of COX-2 mRNA levels enhances the production of prostaglandins, we therefore investigated whether endogenous prostaglandins are involved in the MMP mRNA expression that is enhanced by TNFalpha.	Prostaglandins	66-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-26
12113550-6	2002	Pretreatment with the selective COX-2 inhibitor, NS-398, increased MMP-13 mRNA levels, while prostaglandin E2 and dibutyryl cyclic AMP decreased MMP-13 mRNA levels.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	49-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-37
12134647-3	2002	On the other hand, with progress of basic research in prostaglandin metabolic pathway, receptor and synthase of each prostanoid have been clarified, and selective COX-2 blockers have been developed and are now available in Japan.	Prostaglandins	54-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	163-168
12134647-4	2002	We reviewed the relationship between prostanoids, acute lung injury and the effects of COX-2 selective blockers, and discussed the present status and future perspective in this field.	Prostaglandins	37-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-92
12225656-5	2002	FPI increased SOD-inhibitable NBT reduction, but pretreatment with norbinaltorphimine, a dynorphin antagonist, or NS398, a COX-2 inhibitor, blunted such reduction (1 +/- 1 vs. 19 +/- 3 vs. 4 +/- 1 vs. 4 +/- 1 pmol/mm(2) for control, FPI, FPI-norbinaltorphimine and FPI-NS398, respectively).	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	114-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-128
12225656-11	2002	Finally, these data suggest that NOC/oFQ impairs NMDA dilation postinsult via the sequential release of dynorphin, activation of COX-2, and generation of O(2)(-).	N-Methylaspartate	49-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-134
12032335-8	2002	A selective COX-2 inhibitor reduced platelet production of both PGE(2) and TXB(2) to a significantly greater extent in patients than in healthy subjects.	Prostaglandins E	64-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-17
12032335-8	2002	A selective COX-2 inhibitor reduced platelet production of both PGE(2) and TXB(2) to a significantly greater extent in patients than in healthy subjects.	(2s,3r,4r,5r)-5-Sulfanyloxane-2,3,4-Triol	75-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-17
12032335-10	2002	We conclude that both COX-isoforms contribute to prostanoid formation during human megakaryocytopoiesis and that COX-2-derived PGE(2) and TXA(2) may play an unrecognized role in inflammatory and hemostatic responses in clinical syndromes associated with high platelet turnover.	Prostaglandins E	127-130	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-118
12020867-3	2002	The COX-2 preferring inhibitor, NS-398 (60 microg) significantly reversed tactile allodynia 2 h following injection but this anti-allodynic effect did not last greater than 24 h. Surprisingly, the non-selective COX inhibitor, piroxicam (60 microg) was without effect.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	32-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
12020867-3	2002	The COX-2 preferring inhibitor, NS-398 (60 microg) significantly reversed tactile allodynia 2 h following injection but this anti-allodynic effect did not last greater than 24 h. Surprisingly, the non-selective COX inhibitor, piroxicam (60 microg) was without effect.	Piroxicam	226-235	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
11982397-2	2002	The hydroxyl radical is generated by a Co(II)-mediated Fenton-like reaction, and the hydroxyl radical formation under the experimental condition is indirectly confirmed by the hydroxylation of p-hydroxybenzoic acid.	Hydroxyl Radical	4-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-46
12033987-1	2002	BACKGROUND: Etoricoxib is a highly selective COX-2 inhibitor which was evaluated for the treatment of rheumatoid arthritis (RA).	Etoricoxib	12-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-50
12122682-1	2002	A novel ferrocene-containing helical triangular macrocyclic compound has been constructed through an exchange reaction of hydrazone groups which templated and catalyzed by Co(II) ions.	ferrocene	8-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	172-178
12122682-1	2002	A novel ferrocene-containing helical triangular macrocyclic compound has been constructed through an exchange reaction of hydrazone groups which templated and catalyzed by Co(II) ions.	Hydrazones	122-131	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	172-178
12008128-0	2002	Determination of celecoxib, a COX-2 inhibitor, in pharmaceutical dosage forms by MEKC.	Celecoxib	17-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-35
12008128-1	2002	A micellar electrokinetic chromatographic (MEKC) method was developed for the quantification of celecoxib, a COX-2 inhibitor in pharmaceutical dosage forms within the total analysis time of 7 min.	Celecoxib	96-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-114
12008154-1	2002	A new UV spectrophotometric method (UV method) and a reversed phase liquid chromatographic method (LC method) for the quantitative estimation of celecoxib, a selective COX-2 inhibitor, in pure form and in solid dosage form were developed in the present study.	Celecoxib	145-154	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	168-173
11996407-2	2002	Treatment of calf thymus DNA with Co(II) at 500 microM hydrogen peroxide resulted in a dose-dependent increase in 8-OHdG, which culminated at 25 microM Co(II) (62.6 modified/10(5) dG) and declined at higher Co(II) concentrations [9.6 modified/10(5) dG at 250 microM Co(II)].	Hydrogen Peroxide	55-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-40
11996407-2	2002	Treatment of calf thymus DNA with Co(II) at 500 microM hydrogen peroxide resulted in a dose-dependent increase in 8-OHdG, which culminated at 25 microM Co(II) (62.6 modified/10(5) dG) and declined at higher Co(II) concentrations [9.6 modified/10(5) dG at 250 microM Co(II)].	Hydrogen Peroxide	55-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-158
11996407-2	2002	Treatment of calf thymus DNA with Co(II) at 500 microM hydrogen peroxide resulted in a dose-dependent increase in 8-OHdG, which culminated at 25 microM Co(II) (62.6 modified/10(5) dG) and declined at higher Co(II) concentrations [9.6 modified/10(5) dG at 250 microM Co(II)].	Hydrogen Peroxide	55-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-158
11996407-2	2002	Treatment of calf thymus DNA with Co(II) at 500 microM hydrogen peroxide resulted in a dose-dependent increase in 8-OHdG, which culminated at 25 microM Co(II) (62.6 modified/10(5) dG) and declined at higher Co(II) concentrations [9.6 modified/10(5) dG at 250 microM Co(II)].	Hydrogen Peroxide	55-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-158
11982397-2	2002	The hydroxyl radical is generated by a Co(II)-mediated Fenton-like reaction, and the hydroxyl radical formation under the experimental condition is indirectly confirmed by the hydroxylation of p-hydroxybenzoic acid.	Hydroxyl Radical	85-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-46
11982397-2	2002	The hydroxyl radical is generated by a Co(II)-mediated Fenton-like reaction, and the hydroxyl radical formation under the experimental condition is indirectly confirmed by the hydroxylation of p-hydroxybenzoic acid.	4-hydroxybenzoic acid	193-214	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-46
12074974-6	2002	The enzymatic activities of COX-1 and -2 are inhibited by resveratrol in cell-free models, and COX-2 mRNA and TPA-induced activation of protein kinase C and AP-1-mediated gene expression are suppressed by resveratrol in mammary epithelial cells.	Resveratrol	205-216	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-100
11996407-2	2002	Treatment of calf thymus DNA with Co(II) at 500 microM hydrogen peroxide resulted in a dose-dependent increase in 8-OHdG, which culminated at 25 microM Co(II) (62.6 modified/10(5) dG) and declined at higher Co(II) concentrations [9.6 modified/10(5) dG at 250 microM Co(II)].	8-ohdg	114-120	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-40
11996407-2	2002	Treatment of calf thymus DNA with Co(II) at 500 microM hydrogen peroxide resulted in a dose-dependent increase in 8-OHdG, which culminated at 25 microM Co(II) (62.6 modified/10(5) dG) and declined at higher Co(II) concentrations [9.6 modified/10(5) dG at 250 microM Co(II)].	8-ohdg	114-120	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-158
11996407-2	2002	Treatment of calf thymus DNA with Co(II) at 500 microM hydrogen peroxide resulted in a dose-dependent increase in 8-OHdG, which culminated at 25 microM Co(II) (62.6 modified/10(5) dG) and declined at higher Co(II) concentrations [9.6 modified/10(5) dG at 250 microM Co(II)].	8-ohdg	114-120	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-158
11996407-2	2002	Treatment of calf thymus DNA with Co(II) at 500 microM hydrogen peroxide resulted in a dose-dependent increase in 8-OHdG, which culminated at 25 microM Co(II) (62.6 modified/10(5) dG) and declined at higher Co(II) concentrations [9.6 modified/10(5) dG at 250 microM Co(II)].	8-ohdg	114-120	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-158
11996407-5	2002	Exposure of human diploid fibroblasts to Co(II) at 5-250 microM did not result in an increase in 8-OHdG in a dose-dependent manner, although treated cells showed significantly higher 8-OHdG levels than untreated controls (2.026 +/- 0.695 vs. 1.395 +/- 0.433 8-OHdG/10(5) dG) at all concentrations.	8-ohdg	183-189	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-47
11996407-5	2002	Exposure of human diploid fibroblasts to Co(II) at 5-250 microM did not result in an increase in 8-OHdG in a dose-dependent manner, although treated cells showed significantly higher 8-OHdG levels than untreated controls (2.026 +/- 0.695 vs. 1.395 +/- 0.433 8-OHdG/10(5) dG) at all concentrations.	8-ohdg	183-189	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-47
11996407-6	2002	Our data indicate that in the presence of H2O2, Co(II) stimulates the in vitro formation of 8-OHdG.	Hydrogen Peroxide	42-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-54
11996407-6	2002	Our data indicate that in the presence of H2O2, Co(II) stimulates the in vitro formation of 8-OHdG.	8-ohdg	92-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-54
11965379-2	2002	The transformation of non-selective alpha-(S)-substituted indomethacin ethanolamides to potent, COX-2 selective inhibitors by simple stereocenter inversion highlights this property.	alpha-(s)-substituted indomethacin ethanolamides	36-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-101
12010778-4	2002	NS-398 (1 microM), a cyclo-oxygenase-2 (COX-2) inhibitor, inhibited IL-6 and VEGF production (35+/-4% and 26+/-2%, respectively) but enhanced M-CSF production (38+/-4%) by IL-1beta (1 ng ml(-1)) in synovial fibroblasts isolated from patients with osteoarthritis (OA) and rheumatoid arthritis (RA).	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	0-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
12100094-4	2002	Rofecoxib is a member of a new class of NSAIDs, which selectively inhibits the COX-2 enzyme and therefore is associated with a lower risk of gastrointestinal side-effects; the drug has a long plasma half-life (17 h).	rofecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-84
12016158-0	2002	Deoxycholic acid causes DNA damage in colonic cells with subsequent induction of caspases, COX-2 promoter activity and the transcription factors NF-kB and AP-1.	Deoxycholic Acid	0-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-96
12016158-5	2002	Using transient transfections with reporter constructs, we showed that the transcription factors activator protein-1 (AP-1) and NF-kB were increased in HCT 116 cells, in a dose-dependent fashion, by DCA COX-2 promoter activity was also induced by DCA and using mutant COX-2 promoter plasmids, we showed that the ability of DCA to induce promoter activity was partly dependent upon a functional NF-kB and C/EBP site, and completely dependent on a functional c-AMP response element site.	Deoxycholic Acid	199-202	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	203-208
12016158-5	2002	Using transient transfections with reporter constructs, we showed that the transcription factors activator protein-1 (AP-1) and NF-kB were increased in HCT 116 cells, in a dose-dependent fashion, by DCA COX-2 promoter activity was also induced by DCA and using mutant COX-2 promoter plasmids, we showed that the ability of DCA to induce promoter activity was partly dependent upon a functional NF-kB and C/EBP site, and completely dependent on a functional c-AMP response element site.	Deoxycholic Acid	199-202	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	268-273
12016158-5	2002	Using transient transfections with reporter constructs, we showed that the transcription factors activator protein-1 (AP-1) and NF-kB were increased in HCT 116 cells, in a dose-dependent fashion, by DCA COX-2 promoter activity was also induced by DCA and using mutant COX-2 promoter plasmids, we showed that the ability of DCA to induce promoter activity was partly dependent upon a functional NF-kB and C/EBP site, and completely dependent on a functional c-AMP response element site.	Deoxycholic Acid	247-250	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	203-208
12016158-5	2002	Using transient transfections with reporter constructs, we showed that the transcription factors activator protein-1 (AP-1) and NF-kB were increased in HCT 116 cells, in a dose-dependent fashion, by DCA COX-2 promoter activity was also induced by DCA and using mutant COX-2 promoter plasmids, we showed that the ability of DCA to induce promoter activity was partly dependent upon a functional NF-kB and C/EBP site, and completely dependent on a functional c-AMP response element site.	Deoxycholic Acid	247-250	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	203-208
12016158-5	2002	Using transient transfections with reporter constructs, we showed that the transcription factors activator protein-1 (AP-1) and NF-kB were increased in HCT 116 cells, in a dose-dependent fashion, by DCA COX-2 promoter activity was also induced by DCA and using mutant COX-2 promoter plasmids, we showed that the ability of DCA to induce promoter activity was partly dependent upon a functional NF-kB and C/EBP site, and completely dependent on a functional c-AMP response element site.	c-amp	457-462	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	203-208
12102475-6	2002	Intracellular peroxidation was studied in activated T cells by dihydrorhodamine 123 fluorescence analysis of cells treated with COX-2 antisense or control oligonucleotides.	Oligonucleotides	155-171	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	128-133
12036167-11	2002	The studies reported here suggest that the COX-2-specific inhibitor valdecoxib offers an efficacious and safe alternative to other analgesics used to treat pain after oral surgery.	valdecoxib	68-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
11994707-3	2002	OBJECTIVE: The aim of these studies was to investigate Cox-1 and Cox-2 regulation in NPs of aspirin-tolerant human patients compared with that seen in nasal mucosa (NM).	Aspirin	92-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-70
11994707-8	2002	CONCLUSION: These data showing an abnormal regulation of Cox-1 and Cox-2 in NPs from aspirin-tolerant patients reinforce the concept that prostanoid metabolism might be important in the pathogenesis of inflammatory nasal diseases and suggest a potential role for this alteration in the formation of NPs.	Aspirin	85-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-72
12733982-6	2002	A most promising approach seemed to be the preparation of novel NSAIDs, specific for the inducible isoform of cyclooxygenase (COX-2): they appear to be devoid of gastrointestinal toxicity, in that they spare mucosal prostaglandin synthesis.	Prostaglandins	216-229	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-131
12733982-7	2002	However, a number of recent studies raised serious questions about the two central tenets that support this approach, namely that the prostaglandins that mediate inflammation and pain are produced solely via COX-2 and that the prostaglandins that are important in gastrointestinal and renal function are produced solely via COX-1.	Prostaglandins	134-148	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	208-213
12733982-9	2002	Moreover, COX-2 selective NSAIDs have lost the cardiovascular protective effects of non-selective NSAIDs, effects which are mediated through COX-1 inhibition (in addition, COX-2 has a role in sustaining vascular prostacyclin production).	Epoprostenol	212-224	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
12733982-9	2002	Moreover, COX-2 selective NSAIDs have lost the cardiovascular protective effects of non-selective NSAIDs, effects which are mediated through COX-1 inhibition (in addition, COX-2 has a role in sustaining vascular prostacyclin production).	Epoprostenol	212-224	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	172-177
11950805-8	2002	Injured tissues treated with the selective COX-1 inhibitor SC-560 (5x10(-6) M) or the COX-2 inhibitor NS-398 (5x10(-6) M) recovered to control levels of resistance within three hours, associated with significant elevations of PGE and 6-keto-PGF1alpha compared with untreated tissues.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	102-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-91
11950805-8	2002	Injured tissues treated with the selective COX-1 inhibitor SC-560 (5x10(-6) M) or the COX-2 inhibitor NS-398 (5x10(-6) M) recovered to control levels of resistance within three hours, associated with significant elevations of PGE and 6-keto-PGF1alpha compared with untreated tissues.	Prostaglandins E	226-229	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-91
11950805-8	2002	Injured tissues treated with the selective COX-1 inhibitor SC-560 (5x10(-6) M) or the COX-2 inhibitor NS-398 (5x10(-6) M) recovered to control levels of resistance within three hours, associated with significant elevations of PGE and 6-keto-PGF1alpha compared with untreated tissues.	6-Ketoprostaglandin F1 alpha	234-250	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-91
11950805-10	2002	CONCLUSIONS: The results suggest that recovery of resistance is triggered by PGE and PGI2, which may be elaborated by either COX-1 or COX-2.	Prostaglandins E	77-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-139
11950805-10	2002	CONCLUSIONS: The results suggest that recovery of resistance is triggered by PGE and PGI2, which may be elaborated by either COX-1 or COX-2.	Epoprostenol	85-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-139
11994707-2	2002	Prostanoids are synthesized by 2 cyclooxygenase (Cox) enzymes, one constitutive (Cox-1) and another inducible (Cox-2).	Prostaglandins	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	111-116
11994707-8	2002	CONCLUSION: These data showing an abnormal regulation of Cox-1 and Cox-2 in NPs from aspirin-tolerant patients reinforce the concept that prostanoid metabolism might be important in the pathogenesis of inflammatory nasal diseases and suggest a potential role for this alteration in the formation of NPs.	Prostaglandins	138-148	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-72
11959394-6	2002	In vitro studies revealed that hCOX-2 overexpression in primary cortico-hippocampal neurons derived from the hCOX-2 transgenics accelerates beta-amyloid (Abeta)(1-42)-mediated apoptotic damage which was prevented by the cell cycle dependent (CDK) inhibitor, flavoperidol.	alvocidib	258-270	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-37
11970975-5	2002	Cyclooxygenase (COX)-1- and COX-2-regulated prostanoids present in the primary TDSN were found to be solely responsible for the observed hampered differentiation of monocyte-derived DC (MoDC).	Prostaglandins	44-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
12022326-1	2002	OBJECTIVE: Use of meloxicam as a selective COX-2 inhibitor for treatment of adult rheumatic diseases decreases the frequency of gastrointestinal (GI) side effects in comparison with nonselective COX inhibitors.	Meloxicam	18-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
12113843-3	2002	Five days before admission, rofecoxib, a new selective COX-2 inhibitor nonsteroidal anti-inflammatory drug (NSAID), was added for leg pain.	rofecoxib	28-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-60
11971025-5	2002	We found that PPAR alpha ligands (clofibrate and WY14643) enhanced IL-1 beta-induced COX-2 expression in human astrocytes and microglia, while inhibiting IL-1 beta plus IFN-gamma induction of iNOS in astrocytes.	Clofibrate	34-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-90
11971025-5	2002	We found that PPAR alpha ligands (clofibrate and WY14643) enhanced IL-1 beta-induced COX-2 expression in human astrocytes and microglia, while inhibiting IL-1 beta plus IFN-gamma induction of iNOS in astrocytes.	pirinixic acid	49-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-90
11971025-7	2002	15d-PGJ(2) suppressed COX-2 induction in human astrocytes.	15d-pgj	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-27
11961048-4	2002	Conversely, chronic treatment of the hCOX-2 transgenics with the preferential COX-2 inhibitor nimesulide reversed the hCOX-2-mediated decrease of cortical p18(INK4) mRNA expression in the brain.	nimesulide	94-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-43
11961048-4	2002	Conversely, chronic treatment of the hCOX-2 transgenics with the preferential COX-2 inhibitor nimesulide reversed the hCOX-2-mediated decrease of cortical p18(INK4) mRNA expression in the brain.	nimesulide	94-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-124
11961048-5	2002	Further in vitro studies revealed that in primary cortico-hippocampal neurons derived from homozygous hCOX-2 transgenic mice, COX-2 overexpression accelerates glutamate-mediated apoptotic damage that is prevented by the CDK inhibitor flavoperidol.	Glutamic Acid	159-168	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-108
12144868-0	2002	Downregulation of COX-2 and iNOS by amentoflavone and quercetin in A549 human lung adenocarcinoma cell line.	amentoflavone	36-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-23
12102579-4	2002	Over the past decade, in vitro, preclinical, and clinical data have supported the hypothesis that cyclooxygenase (COX)-2 plays a central role in oncogenesis and that treatment with COX-2 inhibitors offers an effective chemoprevention strategy, as exemplified by the activity of celecoxib (Celebrex) in familial adenomatous polyposis.	Celecoxib	278-287	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-120
12102579-4	2002	Over the past decade, in vitro, preclinical, and clinical data have supported the hypothesis that cyclooxygenase (COX)-2 plays a central role in oncogenesis and that treatment with COX-2 inhibitors offers an effective chemoprevention strategy, as exemplified by the activity of celecoxib (Celebrex) in familial adenomatous polyposis.	Celecoxib	278-287	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	181-186
12102579-4	2002	Over the past decade, in vitro, preclinical, and clinical data have supported the hypothesis that cyclooxygenase (COX)-2 plays a central role in oncogenesis and that treatment with COX-2 inhibitors offers an effective chemoprevention strategy, as exemplified by the activity of celecoxib (Celebrex) in familial adenomatous polyposis.	Celecoxib	289-297	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-120
12102579-4	2002	Over the past decade, in vitro, preclinical, and clinical data have supported the hypothesis that cyclooxygenase (COX)-2 plays a central role in oncogenesis and that treatment with COX-2 inhibitors offers an effective chemoprevention strategy, as exemplified by the activity of celecoxib (Celebrex) in familial adenomatous polyposis.	Celecoxib	289-297	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	181-186
12144868-9	2002	Taken together, our data indicated that amentoflavone and quercetin differentially exerted supression of PGE(2) biosynthesis via downregulation of COX-2/iNOS expression.	amentoflavone	40-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-152
12144868-0	2002	Downregulation of COX-2 and iNOS by amentoflavone and quercetin in A549 human lung adenocarcinoma cell line.	Quercetin	54-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-23
12144868-9	2002	Taken together, our data indicated that amentoflavone and quercetin differentially exerted supression of PGE(2) biosynthesis via downregulation of COX-2/iNOS expression.	Quercetin	58-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-152
12144868-5	2002	Unlike quercetin, amentoflavone inhibited both PGE(2) biosynthesis and COX-2 mRNA and protein expression strongly.	amentoflavone	18-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-76
12144868-9	2002	Taken together, our data indicated that amentoflavone and quercetin differentially exerted supression of PGE(2) biosynthesis via downregulation of COX-2/iNOS expression.	Dinoprostone	105-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-152
11981510-0	2002	Valdecoxib (Bextra)--a new cox-2 inhibitor.	valdecoxib	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-32
12021934-0	2002	COX-2 inhibitor (nimesulide) induced acute liver failure.	nimesulide	17-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
11981510-0	2002	Valdecoxib (Bextra)--a new cox-2 inhibitor.	valdecoxib	12-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-32
12058909-3	2002	Co(II) was then coordinated to the TACN, followed by cobalt oxidation to make polymer A or followed by N-octyl TACN coordination and cobalt oxidation to make polymer B.	Cobalt	53-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
11948457-6	2002	Both sulfide and sulfone metabolites of sulindac, which differ in the ability to cause COX-2 inhibition, induced a significant dose- and time-dependent cell growth reduction accompanied by increase in apoptosis without concomitant cell cycle arrest.	Sulfides	5-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-92
11948457-6	2002	Both sulfide and sulfone metabolites of sulindac, which differ in the ability to cause COX-2 inhibition, induced a significant dose- and time-dependent cell growth reduction accompanied by increase in apoptosis without concomitant cell cycle arrest.	Sulfones	17-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-92
11948457-6	2002	Both sulfide and sulfone metabolites of sulindac, which differ in the ability to cause COX-2 inhibition, induced a significant dose- and time-dependent cell growth reduction accompanied by increase in apoptosis without concomitant cell cycle arrest.	Sulindac	40-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-92
11948457-7	2002	Sulindac treatment also caused upregulation of the protein and mRNA expression levels of COX-2 and PPARs.	Sulindac	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-94
11950315-2	2002	The oxidation of N-alkylamides by O(2), catalyzed by N-hydroxyphthalimide (NHPI) and Co(II) salt, leads under mild conditions to carbonyl derivatives (aldehydes, ketones, carboxylic acids, imides) whose distribution depends on the nature of the alkyl group and on the reaction conditions.	n-alkylamides	17-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-91
11950315-2	2002	The oxidation of N-alkylamides by O(2), catalyzed by N-hydroxyphthalimide (NHPI) and Co(II) salt, leads under mild conditions to carbonyl derivatives (aldehydes, ketones, carboxylic acids, imides) whose distribution depends on the nature of the alkyl group and on the reaction conditions.	o(2)	34-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-91
11950315-2	2002	The oxidation of N-alkylamides by O(2), catalyzed by N-hydroxyphthalimide (NHPI) and Co(II) salt, leads under mild conditions to carbonyl derivatives (aldehydes, ketones, carboxylic acids, imides) whose distribution depends on the nature of the alkyl group and on the reaction conditions.	Aldehydes	151-160	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-91
11950315-2	2002	The oxidation of N-alkylamides by O(2), catalyzed by N-hydroxyphthalimide (NHPI) and Co(II) salt, leads under mild conditions to carbonyl derivatives (aldehydes, ketones, carboxylic acids, imides) whose distribution depends on the nature of the alkyl group and on the reaction conditions.	Ketones	162-169	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-91
12058909-3	2002	Co(II) was then coordinated to the TACN, followed by cobalt oxidation to make polymer A or followed by N-octyl TACN coordination and cobalt oxidation to make polymer B.	Cobalt	133-139	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
11950315-2	2002	The oxidation of N-alkylamides by O(2), catalyzed by N-hydroxyphthalimide (NHPI) and Co(II) salt, leads under mild conditions to carbonyl derivatives (aldehydes, ketones, carboxylic acids, imides) whose distribution depends on the nature of the alkyl group and on the reaction conditions.	Carboxylic Acids	171-187	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-91
11915030-6	2002	The exposure to lipopolysaccharide (LPS) or epidermal growth factor (EGF) determined an increase of PG and NO production in both cell lines and this increase was strongly reduced by COX-2 inhibitors such as celecoxib (CLX) and nimesulide (NIME).	Prostaglandins	100-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	182-187
12007091-1	2002	Carboxylate-bridged chain complexes of Co(II) (the diaquacobalt(II) mono- and ,-dialkanoates) form two homologous series of layered compounds which have been fully characterised both structurally and magnetically.	carboxylate	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-45
12007091-1	2002	Carboxylate-bridged chain complexes of Co(II) (the diaquacobalt(II) mono- and ,-dialkanoates) form two homologous series of layered compounds which have been fully characterised both structurally and magnetically.	mono- and ,-dialkanoates	68-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-45
12007092-1	2002	A combined experimental and theoretical study of the paramagnetic [Co(II)(C12H20N8)(H2O)2] x 2 ClO4 complex was made on the basis of the electron density distribution and topological analysis.	perchlorate	95-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-73
12007092-2	2002	Accurate single-crystal diffraction data were measured on a suitable crystal with Mo(K alpha) radiation at 125 K. The CoII ion is coordinated in a square bipyramidal fashion with four imino nitrogen atoms at the equatorial plane and two water molecules at the axial positions.	imino	184-189	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-122
12007092-2	2002	Accurate single-crystal diffraction data were measured on a suitable crystal with Mo(K alpha) radiation at 125 K. The CoII ion is coordinated in a square bipyramidal fashion with four imino nitrogen atoms at the equatorial plane and two water molecules at the axial positions.	Nitrogen	190-198	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-122
12007092-2	2002	Accurate single-crystal diffraction data were measured on a suitable crystal with Mo(K alpha) radiation at 125 K. The CoII ion is coordinated in a square bipyramidal fashion with four imino nitrogen atoms at the equatorial plane and two water molecules at the axial positions.	Water	237-242	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-122
12033240-4	2002	Like thiourea and Co(II), ascorbic acid was found to significantly enhance the generation efficiency of volatile Cd and As species.	Cadmium	113-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-24
12033246-6	2002	When the determination of Co(II) in an admixture of Cu(II) was carried out using this methodology, the determination limit (2sigma) was obtained as 18 nM, and the absolute amount of Co chelates detected was 0.13 zmol, that is, 78 chelates.	cu(ii)	52-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-32
12047458-4	2002	All the patients were treated for the ISH with celecoxib, a COX-2 specific inhibitor, with full recovery from ISH up to 6 days after it was first administered.	Celecoxib	47-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-65
11910351-4	2002	RESULTS: Bile acids both induced EGFR phosphorylation and enhanced COX-2 protein expression.	Bile Acids and Salts	9-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-72
11910351-6	2002	The MAPK inhibitors, PD098059 for MAP or extracellular signal-regulated kinase 1, SB203580 for p38, and BAY 37-9751 for Raf-1, blocked COX-2 induction by bile acids.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	21-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-140
11910351-6	2002	The MAPK inhibitors, PD098059 for MAP or extracellular signal-regulated kinase 1, SB203580 for p38, and BAY 37-9751 for Raf-1, blocked COX-2 induction by bile acids.	SB 203580	82-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-140
11910351-6	2002	The MAPK inhibitors, PD098059 for MAP or extracellular signal-regulated kinase 1, SB203580 for p38, and BAY 37-9751 for Raf-1, blocked COX-2 induction by bile acids.	Bile Acids and Salts	154-164	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-140
11910351-8	2002	CONCLUSIONS: The results show that EGFR is activated by bile acids and functions to induce COX-2 expression by an MAPK cascade.	Bile Acids and Salts	56-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-96
11929962-3	2002	In contrast, reaction of L(1) and L(2) with Co(II) salts, followed by treatment with tetrafluoroborate or perchlorate, results in assembly of cage complexes having a 4:6 metal:ligand ratio; these complexes have a metal ion at each corner of an approximate tetrahedron, and a bis-bidentate bridging ligand spanning each edge.	perchlorate	106-117	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-50
11929962-3	2002	In contrast, reaction of L(1) and L(2) with Co(II) salts, followed by treatment with tetrafluoroborate or perchlorate, results in assembly of cage complexes having a 4:6 metal:ligand ratio; these complexes have a metal ion at each corner of an approximate tetrahedron, and a bis-bidentate bridging ligand spanning each edge.	Metals	170-175	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-50
11929962-3	2002	In contrast, reaction of L(1) and L(2) with Co(II) salts, followed by treatment with tetrafluoroborate or perchlorate, results in assembly of cage complexes having a 4:6 metal:ligand ratio; these complexes have a metal ion at each corner of an approximate tetrahedron, and a bis-bidentate bridging ligand spanning each edge.	Metals	213-218	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-50
11929962-3	2002	In contrast, reaction of L(1) and L(2) with Co(II) salts, followed by treatment with tetrafluoroborate or perchlorate, results in assembly of cage complexes having a 4:6 metal:ligand ratio; these complexes have a metal ion at each corner of an approximate tetrahedron, and a bis-bidentate bridging ligand spanning each edge.	bis-bidentate	275-288	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-50
11809750-6	2002	The upstream PPAR-responsive element (PPRE) of cyclooxygenase-2 was required for induction of a luciferase reporter by oxidized phospholipids, azPC, and rosiglitazone, and a (COX-2 PPRE)(3)-luciferase reporter was responsive to these PPARgamma agonists.	Phospholipids	128-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	175-180
11809750-6	2002	The upstream PPAR-responsive element (PPRE) of cyclooxygenase-2 was required for induction of a luciferase reporter by oxidized phospholipids, azPC, and rosiglitazone, and a (COX-2 PPRE)(3)-luciferase reporter was responsive to these PPARgamma agonists.	azpc	143-147	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	175-180
11943943-1	2002	Cyclooxygenase (COX) is the crucial enzyme for synthesis of prostaglandins and occurs in two isoforms COX-1 and COX-2.	Prostaglandins	60-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-117
11915030-6	2002	The exposure to lipopolysaccharide (LPS) or epidermal growth factor (EGF) determined an increase of PG and NO production in both cell lines and this increase was strongly reduced by COX-2 inhibitors such as celecoxib (CLX) and nimesulide (NIME).	Celecoxib	207-216	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	182-187
11915030-6	2002	The exposure to lipopolysaccharide (LPS) or epidermal growth factor (EGF) determined an increase of PG and NO production in both cell lines and this increase was strongly reduced by COX-2 inhibitors such as celecoxib (CLX) and nimesulide (NIME).	Celecoxib	218-221	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	182-187
11915030-6	2002	The exposure to lipopolysaccharide (LPS) or epidermal growth factor (EGF) determined an increase of PG and NO production in both cell lines and this increase was strongly reduced by COX-2 inhibitors such as celecoxib (CLX) and nimesulide (NIME).	nimesulide	227-237	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	182-187
11915030-6	2002	The exposure to lipopolysaccharide (LPS) or epidermal growth factor (EGF) determined an increase of PG and NO production in both cell lines and this increase was strongly reduced by COX-2 inhibitors such as celecoxib (CLX) and nimesulide (NIME).	nimesulide	239-243	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	182-187
11894121-12	2002	These findings further support the hypothesis that HMGCo-R and COX-2 activities play important roles in apoptosis and regulation of apoptosis by selective agents such as lovastatin and celecoxib would provide effective strategies for the prevention of colon cancer.	Lovastatin	170-180	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-68
11894121-12	2002	These findings further support the hypothesis that HMGCo-R and COX-2 activities play important roles in apoptosis and regulation of apoptosis by selective agents such as lovastatin and celecoxib would provide effective strategies for the prevention of colon cancer.	Celecoxib	185-194	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-68
11992745-4	2002	It is assumed therefore that the COX-2-selective inhibitors, rofecoxib and celecoxib, would have an effect on renal function similar to that of nonselective NSAIDs.	rofecoxib	61-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-38
11992745-4	2002	It is assumed therefore that the COX-2-selective inhibitors, rofecoxib and celecoxib, would have an effect on renal function similar to that of nonselective NSAIDs.	Celecoxib	75-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-38
11989839-7	2002	COX-2 expression in ESCC cells was significantly increased following treatment with PAF and n-BT.	Platelet Activating Factor	84-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
11961179-2	2002	In patients with rheumatoid arthritis (RA), only one of the COX-2-selective NSAIDs (nabumetone) has been demonstrated to spare platelet function partially.	Nabumetone	84-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-65
11961179-3	2002	OBJECTIVE: To compare the effects of the COX-2-selective inhibitor, meloxicam, with those of the non-selective NSAID, naproxen, on platelet function and thromboxane levels in RA patients.	Meloxicam	68-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-46
11950252-0	2002	Efficacy and safety of the COX-2 specific inhibitor valdecoxib in the management of osteoarthritis of the hip: a randomized, double-blind, placebo-controlled comparison with naproxen.	valdecoxib	52-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-32
11950252-2	2002	This study compared the efficacy of the COX-2 specific inhibitor valdecoxib with naproxen and placebo, in treating symptomatic OA of the hip.	valdecoxib	65-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
11989839-11	2002	PKC inhibitor, however, could abrogate PMA-induced COX-2 gene expression, but it did not block IL-6-induced COX-2 expression.	Tetradecanoylphorbol Acetate	39-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-56
11989839-12	2002	CONCLUSIONS: Our data suggest that COX-2 expression in ESCC cells could be upregulated by PMA, PAF, n-BT and IL-6.	Tetradecanoylphorbol Acetate	90-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40
11989839-7	2002	COX-2 expression in ESCC cells was significantly increased following treatment with PAF and n-BT.	n-bt	92-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
11989839-8	2002	Increased production of PGE2 was detected in the culture media, and the secreted PGE2 in the culture media was proportional to the increased COX-2 expression.	Dinoprostone	81-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	141-146
11850029-8	2002	This study may indicate that overexpression of LPS-stimulated COX-2 induced a greater ability of DGF to produce PGE2, and that these phenomena may be responsible for the severer periodontal disease in DS patients.	Dinoprostone	112-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
11989839-12	2002	CONCLUSIONS: Our data suggest that COX-2 expression in ESCC cells could be upregulated by PMA, PAF, n-BT and IL-6.	Platelet Activating Factor	95-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40
11989839-12	2002	CONCLUSIONS: Our data suggest that COX-2 expression in ESCC cells could be upregulated by PMA, PAF, n-BT and IL-6.	n-bt	100-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40
12044078-0	2002	Kinetics of adsorption of Co(II) removal from water and wastewater by ion exchange resins.	Water	46-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-32
11904314-3	2002	Cyclooxygenase (COX)-2 is the rate-limiting enzyme involved in prostaglandin synthesis.	Prostaglandins	63-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-22
11909556-3	2002	In the medullary region of the kidney, the expression of COX-2 increases in response to a high-salt diet and water deprivation.	Salts	95-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-62
11909557-2	2002	NSAIDs act by inhibiting synthesis of prostaglandins (PGs) from arachidonic acid via cyclooxygenase (COX)-1 and COX-2, the 2 isoforms of COX.	Prostaglandins	38-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-117
11909557-2	2002	NSAIDs act by inhibiting synthesis of prostaglandins (PGs) from arachidonic acid via cyclooxygenase (COX)-1 and COX-2, the 2 isoforms of COX.	Prostaglandins	54-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-117
11909557-8	2002	Apparent differences between the COX-2 inhibitors celecoxib and rofecoxib may be functions of differences in study population susceptibilities to NSAID-mediated hypertensive effects.	Celecoxib	50-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-38
11909557-8	2002	Apparent differences between the COX-2 inhibitors celecoxib and rofecoxib may be functions of differences in study population susceptibilities to NSAID-mediated hypertensive effects.	rofecoxib	64-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-38
11909558-3	2002	However, later research has demonstrated a role of COX-2 in production of PGs that have functions under normal physiologic conditions.	Prostaglandins	74-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-56
11909558-4	2002	In the vasculature, COX-2 seems to be the main enzyme responsible for the production of prostacyclin.	Epoprostenol	88-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-25
11904314-6	2002	COX-2 expression and activity were determined on pooled cell cultures by reverse transcription-polymerase chain reaction and prostaglandin E(2) (PGE(2)) enzyme immunoassay, respectively.	Dinoprostone	125-143	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
11904314-8	2002	PGE(2) levels were determined in supernatants from epithelial cells treated with the selective COX-2 inhibitor NS-398, proinflammatory cytokines (interleukin 1beta and tumor necrosis factor-alpha), and conditioned medium from fibroblast cultures (both unstimulated and stimulated with proinflammatory cytokines).	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	111-117	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-100
11904314-14	2002	CONCLUSION: COX-2 is functionally active in Barrett"s esophagus because treatment with the COX-2 inhibitor hinders proliferation of Barrett"s esophageal epithelial cells in culture, but proliferation is restored by treatment with prostaglandin.	Prostaglandins	230-243	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-17
18968540-1	2002	The sequential simplex algorithm was used to optimize the ion-pair reversed phase high performance liquid chromatographic (IP-RPHPLC) analysis of 4-(2-pyridylazo)resorcinol (PAR) chelates of Co(II), Ni(II) and Cr(III).	4-(2-pyridylazo)resorcinol	146-172	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	191-197
11944671-3	2002	Se(IV) was found to significantly alter Co(ll) sorption as a function of Co(II) surface coverage, while Se(VI) was found to have no effect on Co(II) sorption.	co(ll)	40-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-79
11944671-8	2002	The extent of the Co(ll) sorption reduction in Co(III)/Se(IV) bisorbate systems compared to the corresponding single-sorbate systems increased with increasing Co(II) surface coverage.	co(ll)	18-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	159-165
11944671-8	2002	The extent of the Co(ll) sorption reduction in Co(III)/Se(IV) bisorbate systems compared to the corresponding single-sorbate systems increased with increasing Co(II) surface coverage.	co(iii)	47-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	159-165
11944671-8	2002	The extent of the Co(ll) sorption reduction in Co(III)/Se(IV) bisorbate systems compared to the corresponding single-sorbate systems increased with increasing Co(II) surface coverage.	Selenium	55-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	159-165
11944671-8	2002	The extent of the Co(ll) sorption reduction in Co(III)/Se(IV) bisorbate systems compared to the corresponding single-sorbate systems increased with increasing Co(II) surface coverage.	iv) bisorbate	58-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	159-165
11944671-10	2002	A reaction between Co(II) and Se(IV) is further supported by an increase in Se(IV) sorption in the same bisorbate samples where Co(II) sorption is decreased.	bisorbate	104-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-25
11944671-10	2002	A reaction between Co(II) and Se(IV) is further supported by an increase in Se(IV) sorption in the same bisorbate samples where Co(II) sorption is decreased.	bisorbate	104-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	128-134
11944672-3	2002	To study the impact of anion cosorption on metal cation sorption behavior, Co(II) sorption to gamma-Al2O3 in the presence of selenium oxyanions was investigated.	gamma-al2o3	94-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-81
11944672-3	2002	To study the impact of anion cosorption on metal cation sorption behavior, Co(II) sorption to gamma-Al2O3 in the presence of selenium oxyanions was investigated.	Selenium	125-133	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-81
11944672-4	2002	To aid in the interpretation of macroscopic sorption results, X-ray absorption spectroscopy (XAS) experiments were conducted on single and bisorbate samples where the Co(II) surface coverage of the bisorbate sample was greater than or equal to the single sorbate sample.	bisorbate	198-207	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	167-172
11944672-5	2002	XAS data for single sorbate Co(II) samples were consistent with reported spectra of Co(II)-Al(III) layered double hydroxides (LDHs), indicating coprecipitates are forming in these samples.	al(iii) layered double hydroxides	91-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-90
11944672-7	2002	The extent of the decrease in cobalt second shell features between single and bisorbate samples with equal Co(II) coverage increased with an increase in the Se:Co surface coverage ratio.	Cobalt	30-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-113
18968542-3	2002	EDTA was added to the sample solution to mask large concentrations of Fe(III), Ni(II), Cu(II), Zn(II), Pb(II), Co(II) and Al(III).	Edetic Acid	0-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	111-117
18968545-2	2002	The method is based on the difference in the rate of two processes; reduction of Fe(III) with Co(II) and subsequent complex formation of resulted Fe(II) with 1,10-phenanthroline, and direct complex formation between Fe(II) and 1,10-phenanthroline in pH 3 and cetyl trimethyl ammonium bromide, CTAB, micellar media.	ferric sulfate	81-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-100
18968540-1	2002	The sequential simplex algorithm was used to optimize the ion-pair reversed phase high performance liquid chromatographic (IP-RPHPLC) analysis of 4-(2-pyridylazo)resorcinol (PAR) chelates of Co(II), Ni(II) and Cr(III).	Nickel(2+)	199-205	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	191-197
18968540-1	2002	The sequential simplex algorithm was used to optimize the ion-pair reversed phase high performance liquid chromatographic (IP-RPHPLC) analysis of 4-(2-pyridylazo)resorcinol (PAR) chelates of Co(II), Ni(II) and Cr(III).	Chromium	210-212	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	191-197
12120556-1	2002	In dilute aqueous solution, micelle-forming sodium hexadecylimino diacetate assembles into vesicles induced by Cu(II), Co(II) and Ni(II) ions.	sodium hexadecylimino diacetate	44-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-125
18968529-0	2002	Preconcentration of Cr(III), Co(II), Cu(II), Fe(III) and Pb(II) as calmagite chelates on cellulose nitrate membrane filter prior to their flame atomic absorption spectrometric determinations.	calmagite	67-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-35
11832369-3	2002	Here, we evaluate the relative contribution of cyclooxygenase (COX)-1- and COX-2-derived prostaglandins to anorexia and weight loss precipitated by systemic immune activation by lipopolysaccharide (LPS).	Prostaglandins	89-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
11897923-2	2002	Valdecoxib is a new highly selective COX-2 inhibitor with a rapid onset of action and significant analgesic properties.	valdecoxib	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-42
11891209-16	2002	Finally, the migration of ABC-1 cells was inhibited by MAP kinase kinase inhibitor PD98059 and a selective cox-2 inhibitor NS-398.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	123-129	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-112
11814865-0	2002	Synthesis and biological testing of Acyl-CoA-ketoprofen conjugates as selective irreversible inhibitors of COX-2.	acyl-coa-ketoprofen	36-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-112
11853544-6	2002	SB203580, a selective p38 mitogen-activated protein kinase (MAPK) inhibitor, completely abolished the IL-1beta-induced COX-2 mRNA.	SB 203580	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-124
11896678-8	2002	The results revealed a strong inhibitory potential of Cu(II) [0.4], followed by Ni(II) [3.5] &gt;or= Zn(II) [7.0] &gt;&gt; Cr(III) [73] &gt; Cd(II) [98] &gt;&gt; Co(II) [432] [the numbers in brackets are IC(50) values, microM].	cu(ii)	54-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	162-168
11874389-7	2002	The ratios of IC50s and, at best, of IC80s revealed diclofenac and meloxicam as selective COX-2 inhibitors and ibuprofen as a preferential COX-1 inhibitor in vitro.	Diclofenac	52-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-95
11874389-7	2002	The ratios of IC50s and, at best, of IC80s revealed diclofenac and meloxicam as selective COX-2 inhibitors and ibuprofen as a preferential COX-1 inhibitor in vitro.	Meloxicam	67-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-95
11874389-8	2002	However, after oral intake, ibuprofen inhibited ex vivo COX-2 by 80% whereas diclofenac inhibited COX-1 by 70%.	Ibuprofen	28-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-61
11874389-10	2002	Using in vitro dose--response curves, the in vivo inhibitory potency of diclofenac was estimated adequately from its circulating concentration ([-0.18, 0.21] for COX-1 and [-0.13, -0.03] for COX-2) but this was not the case for ibuprofen on COX-2 ([-0.14, 0.27]) and meloxicam on COX-1 ([0.31, 1.05]).	Diclofenac	72-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	191-196
11874389-10	2002	Using in vitro dose--response curves, the in vivo inhibitory potency of diclofenac was estimated adequately from its circulating concentration ([-0.18, 0.21] for COX-1 and [-0.13, -0.03] for COX-2) but this was not the case for ibuprofen on COX-2 ([-0.14, 0.27]) and meloxicam on COX-1 ([0.31, 1.05]).	Diclofenac	72-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	241-246
11965228-0	2002	Celecoxib: a specific COX-2 inhibitor with anticancer properties.	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-27
11896678-8	2002	The results revealed a strong inhibitory potential of Cu(II) [0.4], followed by Ni(II) [3.5] &gt;or= Zn(II) [7.0] &gt;&gt; Cr(III) [73] &gt; Cd(II) [98] &gt;&gt; Co(II) [432] [the numbers in brackets are IC(50) values, microM].	Zinc	101-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	162-168
11896678-8	2002	The results revealed a strong inhibitory potential of Cu(II) [0.4], followed by Ni(II) [3.5] &gt;or= Zn(II) [7.0] &gt;&gt; Cr(III) [73] &gt; Cd(II) [98] &gt;&gt; Co(II) [432] [the numbers in brackets are IC(50) values, microM].	tris(1,10-phenanthroline)chromium(III) chloride	123-130	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	162-168
12195419-0	2002	[Case report: reversible acute renal failure following therapy with both ketorolac (non-selective non-steroidal anti-inflammatory drug NSAID) and celecoxib (COX-2 selective) in the same patient].	Celecoxib	146-155	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	157-162
11940070-2	2002	OBJECTIVE: To assess the tolerability of rofecoxib, a drug that specifically inhibits COX-2, in a group of NSAID-sensitive patients.	rofecoxib	41-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-91
14561202-11	2002	New highly specific COX-2 inhibitors appear to be a safe alternative for patients with aspirin-induced asthma.	Aspirin	87-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-25
12195419-1	2002	BACKGROUND: We present the case of acute renal failure complicating the course of therapy with both ketorolac (non-selective Non-Steroidal Anti-inflammatory Drug, NSAID), and celecoxib (COX-2 Selective Inhibitor) in an elderly woman with chronic liver disease, heart failure and chronic renal failure.	Celecoxib	175-184	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	186-191
12195419-11	2002	CONCLUSIONS: The case we report seems to confirm that, in patients at risk, the renal adverse effects of non-selective NSAIDs and of COX-2 Inhibitors could be the same due to the similar physiological role of COX-1 and COX-2-dependent prostaglandins.	Prostaglandins	235-249	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	133-138
12195419-11	2002	CONCLUSIONS: The case we report seems to confirm that, in patients at risk, the renal adverse effects of non-selective NSAIDs and of COX-2 Inhibitors could be the same due to the similar physiological role of COX-1 and COX-2-dependent prostaglandins.	Prostaglandins	235-249	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	219-224
11935354-0	2002	Molecular modeling of the three-dimensional structure of Fe(II)-bleomycin: are the Co(II) and Fe(II) adducts isostructural?	iron bleomycin	57-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-89
11897764-4	2002	We report here that both a nonselective NSAID (aspirin, acetylsalicylic acid) and COX-2 selective NSAIDs (celecoxib and NS-398) diminished renal prostacyclin and thromboxane concentration in the renal medulla.	Celecoxib	106-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
11897764-4	2002	We report here that both a nonselective NSAID (aspirin, acetylsalicylic acid) and COX-2 selective NSAIDs (celecoxib and NS-398) diminished renal prostacyclin and thromboxane concentration in the renal medulla.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	120-126	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
11897764-4	2002	We report here that both a nonselective NSAID (aspirin, acetylsalicylic acid) and COX-2 selective NSAIDs (celecoxib and NS-398) diminished renal prostacyclin and thromboxane concentration in the renal medulla.	Epoprostenol	145-157	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
11897764-4	2002	We report here that both a nonselective NSAID (aspirin, acetylsalicylic acid) and COX-2 selective NSAIDs (celecoxib and NS-398) diminished renal prostacyclin and thromboxane concentration in the renal medulla.	Thromboxanes	162-173	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
11935354-0	2002	Molecular modeling of the three-dimensional structure of Fe(II)-bleomycin: are the Co(II) and Fe(II) adducts isostructural?	ammonium ferrous sulfate	57-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-89
11935354-1	2002	The molecular modeling of Co(II)-bleomycin previously performed by us through NMR and molecular dynamics indicates that the most favorable structure for this complex is six-coordinate, with the secondary amine in beta-aminoalanine, the N5 and N1 nitrogens in the pyrimidine and imidazole rings, respectively, and the amide nitrogen in beta-hydroxyhistidine as equatorial ligands.	Amines	204-209	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-32
11935354-1	2002	The molecular modeling of Co(II)-bleomycin previously performed by us through NMR and molecular dynamics indicates that the most favorable structure for this complex is six-coordinate, with the secondary amine in beta-aminoalanine, the N5 and N1 nitrogens in the pyrimidine and imidazole rings, respectively, and the amide nitrogen in beta-hydroxyhistidine as equatorial ligands.	2,3-diaminopropionic acid	213-230	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-32
11935354-1	2002	The molecular modeling of Co(II)-bleomycin previously performed by us through NMR and molecular dynamics indicates that the most favorable structure for this complex is six-coordinate, with the secondary amine in beta-aminoalanine, the N5 and N1 nitrogens in the pyrimidine and imidazole rings, respectively, and the amide nitrogen in beta-hydroxyhistidine as equatorial ligands.	Nitrogen	246-255	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-32
11935354-1	2002	The molecular modeling of Co(II)-bleomycin previously performed by us through NMR and molecular dynamics indicates that the most favorable structure for this complex is six-coordinate, with the secondary amine in beta-aminoalanine, the N5 and N1 nitrogens in the pyrimidine and imidazole rings, respectively, and the amide nitrogen in beta-hydroxyhistidine as equatorial ligands.	pyrimidine	263-273	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-32
11935354-1	2002	The molecular modeling of Co(II)-bleomycin previously performed by us through NMR and molecular dynamics indicates that the most favorable structure for this complex is six-coordinate, with the secondary amine in beta-aminoalanine, the N5 and N1 nitrogens in the pyrimidine and imidazole rings, respectively, and the amide nitrogen in beta-hydroxyhistidine as equatorial ligands.	imidazole	278-287	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-32
11935354-1	2002	The molecular modeling of Co(II)-bleomycin previously performed by us through NMR and molecular dynamics indicates that the most favorable structure for this complex is six-coordinate, with the secondary amine in beta-aminoalanine, the N5 and N1 nitrogens in the pyrimidine and imidazole rings, respectively, and the amide nitrogen in beta-hydroxyhistidine as equatorial ligands.	Amides	317-322	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-32
11935354-1	2002	The molecular modeling of Co(II)-bleomycin previously performed by us through NMR and molecular dynamics indicates that the most favorable structure for this complex is six-coordinate, with the secondary amine in beta-aminoalanine, the N5 and N1 nitrogens in the pyrimidine and imidazole rings, respectively, and the amide nitrogen in beta-hydroxyhistidine as equatorial ligands.	Nitrogen	246-254	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-32
11935354-1	2002	The molecular modeling of Co(II)-bleomycin previously performed by us through NMR and molecular dynamics indicates that the most favorable structure for this complex is six-coordinate, with the secondary amine in beta-aminoalanine, the N5 and N1 nitrogens in the pyrimidine and imidazole rings, respectively, and the amide nitrogen in beta-hydroxyhistidine as equatorial ligands.	beta-hydroxyhistidine	335-356	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-32
11935354-6	2002	The results of this investigation on Fe(II)- and Co(II)-bleomycin are most consistent with a six-coordinate structure with five endogenous N-donors and a solvent molecule or the carbamoyl group as the sixth ligand.	Bleomycin	56-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-55
11935354-6	2002	The results of this investigation on Fe(II)- and Co(II)-bleomycin are most consistent with a six-coordinate structure with five endogenous N-donors and a solvent molecule or the carbamoyl group as the sixth ligand.	Nitrogen	139-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-55
11935355-1	2002	The equilibrium constants and the thermodynamic parameters enthalpy and entropy of the interaction between Ni(II) and Co(II) with NAD(+) in aqueous solution were determined by calorimetry and potentiometry methods (ionic strength adjusted to 0.1 with sodium nitrate at 25 degrees C).	Nickel(2+)	107-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-124
11935355-1	2002	The equilibrium constants and the thermodynamic parameters enthalpy and entropy of the interaction between Ni(II) and Co(II) with NAD(+) in aqueous solution were determined by calorimetry and potentiometry methods (ionic strength adjusted to 0.1 with sodium nitrate at 25 degrees C).	NAD	130-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-124
16290451-0	2002	Influence of surface composition on hydrogen peroxide decomposition catalyzed by Co(II) aminopyridine-supported compounds on amorphous silica gel.	Hydrogen Peroxide	36-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-87
11935355-1	2002	The equilibrium constants and the thermodynamic parameters enthalpy and entropy of the interaction between Ni(II) and Co(II) with NAD(+) in aqueous solution were determined by calorimetry and potentiometry methods (ionic strength adjusted to 0.1 with sodium nitrate at 25 degrees C).	sodium nitrate	251-265	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-124
16290451-0	2002	Influence of surface composition on hydrogen peroxide decomposition catalyzed by Co(II) aminopyridine-supported compounds on amorphous silica gel.	Silica Gel	135-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-87
12017180-2	2002	To gain further insight into the molecular pathogenesis of pulpitis, we investigated the effects of IL-1alpha or TNF-alpha and PGE2, either alone or in combination on IL-6 and cyclooxygenase (COX)-2 messenger RNA (mRNA) production in cultured human dental pulp (HDP) fibroblasts.	Dinoprostone	127-131	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	176-198
12017180-9	2002	Furthermore, expression of IL-6 and COX-2 genes in this cell seems to be differentially regulated by cytokines through prostaglandin-dependent and -independent pathways.	Prostaglandins	119-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-41
11867096-3	2002	The gerronemins blocked the inducible expression of a hCOX-2 and iNOS promoter driven reporter gene with IC50-values of 1-5 microg/ml.	gerronemins	4-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-60
11859113-4	2002	Constitutively present in BM-DC, cyclooxygenase (COX)-1 did not contribute significantly to the total pool of PGE(2) compared with the LPS-induced COX-2-produced PGE(2).	Prostaglandins E	162-165	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-152
11859113-6	2002	In addition, selective inhibition of COX-2, but not COX-1, was followed by significant decrements in PGE(2) and IL-10, a concomitant restoration of IL-12 production, and an enhancement of DC stimulatory potential.	Prostaglandins E	101-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-42
11859113-9	2002	We found that exogenous IL-10 inhibits IL-12p70 production in the presence of NS-398, a COX-2 selective inhibitor, while the inhibitory effects of PGE(2) were totally reversed by anti-IL-10.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	78-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-93
11859113-10	2002	We conclude that COX-2-mediated PGE(2) up-regulates IL-10, which down-regulates IL-12 production and the APC function of BM-DC.	Prostaglandins E	32-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22
11875501-1	2002	Prostaglandins (PGs), bioactive lipid molecules produced by cyclooxygenase enzymes (COX-1 and COX-2), have diverse biological activities, including growth-promoting actions on gastrointestinal mucosa.	Prostaglandins	0-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-99
11875501-1	2002	Prostaglandins (PGs), bioactive lipid molecules produced by cyclooxygenase enzymes (COX-1 and COX-2), have diverse biological activities, including growth-promoting actions on gastrointestinal mucosa.	Prostaglandins	16-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-99
11898894-2	2002	Rofecoxib, a COX-2-specific NSAID, does not inhibit the COX-1 enzyme, thereby decreasing the potential for gastrointestinal-related adverse effects.	rofecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
11844666-1	2002	We have recently described how to achieve COX-2 selectivity from the non-selective inhibitor indomethacin (1) using a combination of a pharmacophore and computer 3-D models based on the known X-ray crystal structures of cyclooxygenases.	Indomethacin	93-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47
11844666-2	2002	In the present study we have focused on the design of COX-2 selective analogues of the NSAID ketoprofen (2).	Ketoprofen	93-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-59
11849066-3	2002	These compounds consisted mainly of the Fe(III)-CN-Co(II) site (HT phase) around room temperature but turned to the state consisting mainly of the Fe(II)-CN-Co(III) site (LT phase) at low temperatures.	ferric sulfate	40-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-57
11844666-5	2002	The resulting series of compounds bearing this central framework is exemplified by the potent and selective COX-2 inhibitor 17 (LM-1669).	CHEMBL151128	128-135	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-113
11849066-7	2002	The energy difference of two phases is determined by the ligand field strength around Co(II) ions, which can be controlled by Co/Fe.	Iron	129-131	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-92
11841277-6	2002	A demonstration of the utility of this new organocatalytic alkylation for the rapid construction of biomedically relevant molecules is presented in the enantioselective synthesis of an indolobutyric acid COX-2 inhibitor.	indolobutyric	185-198	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	204-209
11857709-0	2002	Supramolecular assemblies of a bis(terpyridine) ligand and of its [2x2] grid-type Zn(II) and Co(II) complexes on highly ordered pyrolytic graphite.	bis(terpyridine)	31-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-99
11857709-0	2002	Supramolecular assemblies of a bis(terpyridine) ligand and of its [2x2] grid-type Zn(II) and Co(II) complexes on highly ordered pyrolytic graphite.	Graphite	138-146	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-99
11857709-4	2002	Similar adsorption experiments with one of the corresponding [2x2] Co(II) grid-type complexes on graphite, led also to a well-organised structure with interdigitation of the extra-pyridine moieties.	Graphite	97-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-73
11857709-4	2002	Similar adsorption experiments with one of the corresponding [2x2] Co(II) grid-type complexes on graphite, led also to a well-organised structure with interdigitation of the extra-pyridine moieties.	pyridine	180-188	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-73
16290410-7	2002	This differential behavior can be effectively used for the decontamination of alkali metal, alkaline earth metal, and ammonium salts from Cu(II), Ni(II), Co(II), and Zn(II) ions via solid phase extraction following AAS measurement.	Metals	85-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	154-159
16290410-7	2002	This differential behavior can be effectively used for the decontamination of alkali metal, alkaline earth metal, and ammonium salts from Cu(II), Ni(II), Co(II), and Zn(II) ions via solid phase extraction following AAS measurement.	Metals	107-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	154-159
16290410-7	2002	This differential behavior can be effectively used for the decontamination of alkali metal, alkaline earth metal, and ammonium salts from Cu(II), Ni(II), Co(II), and Zn(II) ions via solid phase extraction following AAS measurement.	ammonium salts	118-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	154-159
16290410-7	2002	This differential behavior can be effectively used for the decontamination of alkali metal, alkaline earth metal, and ammonium salts from Cu(II), Ni(II), Co(II), and Zn(II) ions via solid phase extraction following AAS measurement.	cu(ii)	138-144	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	154-159
11814774-0	2002	Estimation of binding affinities for celecoxib analogues with COX-2 via Monte Carlo-extended linear response.	Celecoxib	37-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
11820781-11	2002	These results, collectively, suggest a ROS-related, COX-2-independent mechanism for the induction of drug resistance gene expression that bears important implications to the roles of NSAIDs in colorectal carcinogenesis and inflammatory response.	Reactive Oxygen Species	39-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-57
11814774-1	2002	Monte Carlo (MC)-extended linear response (ELR) calculations have been used for prediction of binding affinities of celecoxib analogues with the COX-2 enzyme.	Celecoxib	116-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-150
11823092-2	2002	Aspirin, a nonselective COX-1 (cyclo-oxygenase) and COX-2 inhibitor may result in gastric toxicity.	Aspirin	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-57
11810182-3	2002	Chronic treatment of mice with the selective COX-2 inhibitor nimesulide reduced the hCOX-2-mediated induction of hippocampal C1qB mRNA expression.	nimesulide	61-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-90
11856027-7	2002	It returns the Co(II) form of the catalyst generated after the reaction to the active Co(I) state, and by removing Co(II) it also prevents the nonproductive recombination of alkyl radicals with cob(II)alamin.	alkyl radicals	174-188	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-21
11856027-7	2002	It returns the Co(II) form of the catalyst generated after the reaction to the active Co(I) state, and by removing Co(II) it also prevents the nonproductive recombination of alkyl radicals with cob(II)alamin.	alkyl radicals	174-188	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-121
11858847-0	2002	COX-1/COX-2 inhibitors based on the methanone moiety.	CHEBI:29335	36-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	6-11
11856027-7	2002	It returns the Co(II) form of the catalyst generated after the reaction to the active Co(I) state, and by removing Co(II) it also prevents the nonproductive recombination of alkyl radicals with cob(II)alamin.	cob(II)alamin	194-207	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-21
11856027-7	2002	It returns the Co(II) form of the catalyst generated after the reaction to the active Co(I) state, and by removing Co(II) it also prevents the nonproductive recombination of alkyl radicals with cob(II)alamin.	cob(II)alamin	194-207	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-121
11856046-0	2002	Catalytic radical addition of carbonyl compounds to alkenes by Mn(II)/Co(II)/O(2) system.	Alkenes	52-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-76
11856046-0	2002	Catalytic radical addition of carbonyl compounds to alkenes by Mn(II)/Co(II)/O(2) system.	Manganese(2+)	63-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-76
11856046-0	2002	Catalytic radical addition of carbonyl compounds to alkenes by Mn(II)/Co(II)/O(2) system.	o(2)	77-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-76
11856046-1	2002	The radical addition of enolizable carbonyl compounds such as malonates and malononitrile to alkenes was successfully achieved through a catalytic process using the Mn(II)/Co(II)/O(2) system to afford the corresponding adducts in fair to good yields.	Malonates	62-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	172-178
11856046-1	2002	The radical addition of enolizable carbonyl compounds such as malonates and malononitrile to alkenes was successfully achieved through a catalytic process using the Mn(II)/Co(II)/O(2) system to afford the corresponding adducts in fair to good yields.	dicyanmethane	76-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	172-178
11856046-1	2002	The radical addition of enolizable carbonyl compounds such as malonates and malononitrile to alkenes was successfully achieved through a catalytic process using the Mn(II)/Co(II)/O(2) system to afford the corresponding adducts in fair to good yields.	Alkenes	93-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	172-178
11856046-1	2002	The radical addition of enolizable carbonyl compounds such as malonates and malononitrile to alkenes was successfully achieved through a catalytic process using the Mn(II)/Co(II)/O(2) system to afford the corresponding adducts in fair to good yields.	Manganese(2+)	165-171	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	172-178
11856046-1	2002	The radical addition of enolizable carbonyl compounds such as malonates and malononitrile to alkenes was successfully achieved through a catalytic process using the Mn(II)/Co(II)/O(2) system to afford the corresponding adducts in fair to good yields.	o(2)	179-183	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	172-178
11901304-3	2002	COX-2, a key isoenzyme in conversion of arachidonic acid to prostaglandins, is inducible by various agents such as growth factors and tumor promoters, and is frequently overexpressed in various tumors.	Arachidonic Acid	40-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
11901304-3	2002	COX-2, a key isoenzyme in conversion of arachidonic acid to prostaglandins, is inducible by various agents such as growth factors and tumor promoters, and is frequently overexpressed in various tumors.	Prostaglandins	60-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
11901304-4	2002	The contribution of COX-2 to carcinogenesis and the malignant phenotype of tumor cells has been thought to be related to its abilities to (i) increase production of prostaglandins, (ii) convert procarcinogens to carcinogens, (iii) inhibit apoptosis, (iv) promote angiogenesis, (v) modulate inflammation and immune function, and (vi) increase tumor cell invasiveness, although some studies indicated that NSAIDs have COX-2-independent effects.	Prostaglandins	165-179	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-25
11911558-13	2002	CONCLUSION: In this study, addition of tramadol/acetaminophen to NSAID or COX-2-selective inhibitor therapy was well tolerated and effective in the treatment of OA flare pain.	Tramadol	39-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
11911558-13	2002	CONCLUSION: In this study, addition of tramadol/acetaminophen to NSAID or COX-2-selective inhibitor therapy was well tolerated and effective in the treatment of OA flare pain.	Acetaminophen	48-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
12020053-1	2002	Pharmacia (formerly Searle), in collaboration with Pfizer and Yamanouchi, has developed valdecoxib, a second-generation cyclooxygenase (COX)-2 inhibitor as a follow-up to celecoxib, for the treatment of arthritis.	valdecoxib	88-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	136-142
12020053-5	2002	The company claims that valdecoxib has improved potency and broader therapeutic range than other COX-2 inhibitors including celecoxib, and has the potential for once-daily dosing [287279], [313957].	valdecoxib	24-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
12020053-7	2002	Valdecoxib has been described by Searle as almost superimposable at the site critical for COX-2 inhibition, a structural side pocket in the enzyme which coincides with the sulfonamide group of the drug [324667].	valdecoxib	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-95
12020053-7	2002	Valdecoxib has been described by Searle as almost superimposable at the site critical for COX-2 inhibition, a structural side pocket in the enzyme which coincides with the sulfonamide group of the drug [324667].	Sulfonamides	172-183	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-95
11882577-1	2002	Interleukin-1beta (IL-1beta), a proinflammatory cytokine, induces cyclooxygenase-2 (COX-2) in cultured neonatal ventricular myocytes (NVMs), resulting in the preferential production of prostaglandin E(2) (PGE(2)).	Dinoprostone	185-203	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-89
12940040-1	2002	In this paper, the conventional fluorescence spectra and laser induced fluorescence spectra of a novel macrocyclic dioxotetramine, 1,4,7,10-tetraazacyclotridecane-11,13-dionato and its Cu(II), Co(II), Ni(II) complexes at different pH are studied.	dioxotetramine	115-129	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	193-199
11882577-1	2002	Interleukin-1beta (IL-1beta), a proinflammatory cytokine, induces cyclooxygenase-2 (COX-2) in cultured neonatal ventricular myocytes (NVMs), resulting in the preferential production of prostaglandin E(2) (PGE(2)).	Prostaglandins E	205-208	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-89
11882577-11	2002	We concluded that (1) PGE(2) production requires the induction of its specific synthase; (2) in myocytes, the inducible enzymes COX-2 and PGES are perinuclear; and (3) PGE(2) and sulprostone induce cardiac myocyte growth but seem to activate a different subset of EP receptors.	Prostaglandins E	22-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	128-133
11882577-11	2002	We concluded that (1) PGE(2) production requires the induction of its specific synthase; (2) in myocytes, the inducible enzymes COX-2 and PGES are perinuclear; and (3) PGE(2) and sulprostone induce cardiac myocyte growth but seem to activate a different subset of EP receptors.	sulprostone	179-190	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	128-133
11805193-7	2002	However, although COX-2 was initially regarded as a source of pathological prostanoids only, recent studies have indicated that this isoenzyme mediates a variety of physiological responses within the organism.	Prostaglandins	75-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-23
11897504-4	2002	The prostaglandin PGE(2) increases intracellular cAMP levels and stimulates estrogen biosynthesis, and our recent studies have shown a strong linear association between CYP19 expression and the sum of cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) expression in breast cancer specimens.	Dinoprostone	18-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	248-253
11897504-8	2002	In breast adenocarcinoma cells, EGF and TGFbeta did not alter COX-2 levels at 24h, while TPA induced COX-2 levels by 75% in MDA-MB-231 cells.	Tetradecanoylphorbol Acetate	89-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-106
11897504-12	2002	A dramatic induction of COX-2 was observed in the adipose stromal cells by EGF, TGFbeta, and TPA.	Tetradecanoylphorbol Acetate	93-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
11897504-16	2002	Furthermore, increased secretion of prostaglandins such as PGE(2) from constitutive COX-1 and inducible COX-2 isozymes present in epithelial and stromal cell compartments will result in both autocrine and paracrine actions to increase aromatase expression in the tissues.	Prostaglandins	36-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
11897504-16	2002	Furthermore, increased secretion of prostaglandins such as PGE(2) from constitutive COX-1 and inducible COX-2 isozymes present in epithelial and stromal cell compartments will result in both autocrine and paracrine actions to increase aromatase expression in the tissues.	Dinoprostone	59-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
11926591-1	2002	Cyclooxygenase (COX), existing as the COX-1 and COX-2 isoforms, converts arachidonic acid to prostaglandin H2, which is then further metabolized to various prostaglandins.	Arachidonic Acid	73-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-53
11926591-1	2002	Cyclooxygenase (COX), existing as the COX-1 and COX-2 isoforms, converts arachidonic acid to prostaglandin H2, which is then further metabolized to various prostaglandins.	Prostaglandin H2	93-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-53
11926591-1	2002	Cyclooxygenase (COX), existing as the COX-1 and COX-2 isoforms, converts arachidonic acid to prostaglandin H2, which is then further metabolized to various prostaglandins.	Prostaglandins	156-170	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-53
11926591-2	2002	Vascular endothelial growth factor (VEGF) has been shown to play important roles in inflammation and is upregulated by the prostaglandin E series through COX-2 in several cell types.	Prostaglandins E	123-138	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	154-159
11926591-5	2002	The activity of COX-2 was assessed by measuring the production of 6-keto-prostaglandin F1alpha in the presence of exogenous arachidonic acids (10 microM, 10 min) by enzyme immunoassay.	6-Ketoprostaglandin F1 alpha	66-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-21
11926591-5	2002	The activity of COX-2 was assessed by measuring the production of 6-keto-prostaglandin F1alpha in the presence of exogenous arachidonic acids (10 microM, 10 min) by enzyme immunoassay.	Arachidonic Acids	124-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-21
11926591-9	2002	Interestingly, the increased COX-2 protein and activity in response to VEGF (10 ng/ml) was inhibited by the tyrosine kinase inhibitor, genistein (0.05-5 microg/ml), but not by the protein kinase C inhibitor, staurosporine (0.1-10 ng/ml).	Genistein	135-144	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34
11926591-9	2002	Interestingly, the increased COX-2 protein and activity in response to VEGF (10 ng/ml) was inhibited by the tyrosine kinase inhibitor, genistein (0.05-5 microg/ml), but not by the protein kinase C inhibitor, staurosporine (0.1-10 ng/ml).	Staurosporine	208-221	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34
11809901-9	2002	Another peak corresponding to methylated CpG islands was observed on the chromatogram of the Cox-2-methylated AGS cell line after bisulfite treatment.	hydrogen sulfite	130-139	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-98
11821061-5	2002	Although moDCs failed to mobilize endogenous arachidonic acid, they converted exogenous arachidonic acid into PGE2 in a COX-1- and COX-2-dependent fashion.	Arachidonic Acid	88-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-136
11821061-5	2002	Although moDCs failed to mobilize endogenous arachidonic acid, they converted exogenous arachidonic acid into PGE2 in a COX-1- and COX-2-dependent fashion.	Dinoprostone	110-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-136
11800617-0	2002	Criteria for liquid crystal formation in 5-alkoxy-, 5-alkylamino-, and 5-alkanoyl-tropolone complexes of transition metals (Cu(II), Zn(II), Ni(II), Co(II), UO(2)(VI), VO(IV)).	5-alkoxy-, 5-alkylamino-, and 5-alkanoyl-tropolone	41-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	148-154
11774276-5	2002	Methylation of COX-2 was closely associated with loss of expression and treatment of methylation inhibitor, 5-deoxy-2"-azacytidine restored the expression of COX-2.	5-deoxy-2"-azacytidine	108-130	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-20
11774276-5	2002	Methylation of COX-2 was closely associated with loss of expression and treatment of methylation inhibitor, 5-deoxy-2"-azacytidine restored the expression of COX-2.	5-deoxy-2"-azacytidine	108-130	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	158-163
11774276-6	2002	A combined treatment of 5-deoxy-2"-azacytidine and a histone deacetylese inhibitor, trichostatin A, restored re-expression of the gene synergistically and chromatin immunoprecipitation analysis revealed that histone of methylated COX-2 promoter is deacetylated, indicating the role of cytosine methylation and histone deacetylation in the silencing of the gene.	5-deoxy-2"-azacytidine	24-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	230-235
11774276-6	2002	A combined treatment of 5-deoxy-2"-azacytidine and a histone deacetylese inhibitor, trichostatin A, restored re-expression of the gene synergistically and chromatin immunoprecipitation analysis revealed that histone of methylated COX-2 promoter is deacetylated, indicating the role of cytosine methylation and histone deacetylation in the silencing of the gene.	trichostatin A	84-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	230-235
11788705-7	2002	The cDNA analysis of the head-to-tail ligated cox2 mRNA identified 3" ends within a thymidine stretch approximately 300 nt downstream of the reading frame in a sequence segment that was not present in the previous investigation of this gene.	Thymidine	84-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-50
11843162-4	2002	The reaction of the pseudorotaxanes with various transition metal ions including CuII, CoII, NiII, AgI, and CdII produces 1D or 2D polyrotaxanes, in which many molecular "beads" are threaded onto 1D or 2D coordination polymers as confirmed by X-ray crystallography.	Rotaxanes	20-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-91
11843162-4	2002	The reaction of the pseudorotaxanes with various transition metal ions including CuII, CoII, NiII, AgI, and CdII produces 1D or 2D polyrotaxanes, in which many molecular "beads" are threaded onto 1D or 2D coordination polymers as confirmed by X-ray crystallography.	Metals	60-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-91
11843162-4	2002	The reaction of the pseudorotaxanes with various transition metal ions including CuII, CoII, NiII, AgI, and CdII produces 1D or 2D polyrotaxanes, in which many molecular "beads" are threaded onto 1D or 2D coordination polymers as confirmed by X-ray crystallography.	Rotaxanes	131-144	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-91
11803035-10	2002	Upon conversion of these alkylated structures to the corresponding 113Cd2+ species 113Cd NMR spectroscopy established that the location of Co(II) in Co(n)-MT (n=1-3) was non-specific and that at n=4, the only observable structure was Co(II)4S11.	113cd2+	67-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-145
11779161-2	2002	PGE(2) biosynthesis by cyclooxygenase (COX)-2 plays a pivotal role in inflammation and carcinogenesis.	Dinoprostone	0-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-45
11803035-10	2002	Upon conversion of these alkylated structures to the corresponding 113Cd2+ species 113Cd NMR spectroscopy established that the location of Co(II) in Co(n)-MT (n=1-3) was non-specific and that at n=4, the only observable structure was Co(II)4S11.	Cadmium, isotope of mass 113	67-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-145
11803035-10	2002	Upon conversion of these alkylated structures to the corresponding 113Cd2+ species 113Cd NMR spectroscopy established that the location of Co(II) in Co(n)-MT (n=1-3) was non-specific and that at n=4, the only observable structure was Co(II)4S11.	co(n)	149-154	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-145
11803035-10	2002	Upon conversion of these alkylated structures to the corresponding 113Cd2+ species 113Cd NMR spectroscopy established that the location of Co(II) in Co(n)-MT (n=1-3) was non-specific and that at n=4, the only observable structure was Co(II)4S11.	co(ii)4s11	234-244	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-145
11808731-0	2002	Investigation of the spectral properties of a squarylium near-infrared dye and its complexation with Fe(III) and Co(II) ions.	squarylium	46-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-119
11779161-4	2002	We hypothesized that increased expression of COX-2, with resultant increased levels of PGE(2) in human PIN cells, activates the IL-6 signaling pathway.	Prostaglandins E	87-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-50
11779161-10	2002	These data provide mechanistic evidence that increased expression of COX-2/PGE(2) contributes to prostate cancer development and progression via activation of the IL-6 signaling pathway.	Prostaglandins E	75-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-74
11677234-2	2002	Prostaglandin synthesis by cyclooxygenases-1 and -2 (COX-1 and COX-2) involves an initial oxygenation of arachidonic acid at C-11, followed by endoperoxide and cyclopentane ring formation, and then a second reaction with molecular oxygen in the S configuration at C-15.	endoperoxide	143-155	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-68
11677234-2	2002	Prostaglandin synthesis by cyclooxygenases-1 and -2 (COX-1 and COX-2) involves an initial oxygenation of arachidonic acid at C-11, followed by endoperoxide and cyclopentane ring formation, and then a second reaction with molecular oxygen in the S configuration at C-15.	Prostaglandins	0-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-68
11677234-2	2002	Prostaglandin synthesis by cyclooxygenases-1 and -2 (COX-1 and COX-2) involves an initial oxygenation of arachidonic acid at C-11, followed by endoperoxide and cyclopentane ring formation, and then a second reaction with molecular oxygen in the S configuration at C-15.	Arachidonic Acid	105-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-68
11822399-6	2002	An isocratic method using a 0.035 M KCl, 0.065 M KNO3 (pH 2.5) eluent was successfully applied to the determination of Mn(II), Cd(II), Co(II) and Zn(II) at concentrations between 20 and 121 microg/l in a freshwater certified reference material (NIST 1640).	Potassium Chloride	36-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-141
12664572-0	2002	Endothelial COX-2 induction by hypoxia liberates 6-keto-PGF1 alpha, a potent epithelial secretagogue.	6-Ketoprostaglandin F1 alpha	49-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-17
12664617-9	2002	A COX inhibitor, indomethacin, suppressed the stimulated growth, increased DNA synthesis and induction of epidermal growth factor receptor in the COX-1 and COX-2-transfected cells.	Indomethacin	17-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	156-161
12664626-0	2002	LPS-induced synthesis and release of PGE2 in liver macrophages: regulation by CPLA2, COX-1, COX-2, and PGE2 synthase.	Dinoprostone	37-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-97
11842416-3	2002	When the Co(II)/Carnos ratio is &lt;or=1, peroxobinuclear complexes are the predominant species and two forms (monobridged and dibridged) are identified by the presence of two Raman peaks in the nuO-O region (750-850 cm(-1)).	nuo-o	195-200	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	9-15
11842416-5	2002	In addition, the chelated species in the 2 : 1 Co(II)/Carnos system is found to bind oxygen to a lesser degree.	carnos	54-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-53
11842416-5	2002	In addition, the chelated species in the 2 : 1 Co(II)/Carnos system is found to bind oxygen to a lesser degree.	Oxygen	85-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-53
11842416-6	2002	With respect to the coordination sites, each Co(II) ion of the binuclear dioxygenated complexes is bound to one oxygen atom and four nitrogen atoms: N(pi) and N(tau) of two Carnos molecules, the peptide, and the terminal amino nitrogen atoms.	Oxygen	75-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-51
11842416-6	2002	With respect to the coordination sites, each Co(II) ion of the binuclear dioxygenated complexes is bound to one oxygen atom and four nitrogen atoms: N(pi) and N(tau) of two Carnos molecules, the peptide, and the terminal amino nitrogen atoms.	Nitrogen	133-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-51
11842416-6	2002	With respect to the coordination sites, each Co(II) ion of the binuclear dioxygenated complexes is bound to one oxygen atom and four nitrogen atoms: N(pi) and N(tau) of two Carnos molecules, the peptide, and the terminal amino nitrogen atoms.	Nitrogen	227-235	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-51
12209450-2	2002	The tested catechols were found to reduce the light emission accompanying oxidation of farmorubicin by Co(II) + H2O2 and Cu(II) + H2O2 mixtures.	Catechols	11-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-109
12209450-2	2002	The tested catechols were found to reduce the light emission accompanying oxidation of farmorubicin by Co(II) + H2O2 and Cu(II) + H2O2 mixtures.	Epirubicin	87-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-109
11815387-8	2002	However, group A acted through the NF-kappaB pathway to inhibit COX2 as the response was blocked by the inhibitor geldanamycin which prevents dissociation of GR and the effect was blocked by APDC, the NF-kappaB inhibitor.	geldanamycin	114-126	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-68
11756226-5	2002	The tumor promoters phorbol 12-myristate 13-acetate (PMA) and chenodeoxycholic acid (CD) induced COX-2 protein expression in transformed, but not non-transformed cells.	Tetradecanoylphorbol Acetate	20-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
11756226-5	2002	The tumor promoters phorbol 12-myristate 13-acetate (PMA) and chenodeoxycholic acid (CD) induced COX-2 protein expression in transformed, but not non-transformed cells.	Tetradecanoylphorbol Acetate	53-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
11756226-5	2002	The tumor promoters phorbol 12-myristate 13-acetate (PMA) and chenodeoxycholic acid (CD) induced COX-2 protein expression in transformed, but not non-transformed cells.	Chenodeoxycholic Acid	62-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
11756226-5	2002	The tumor promoters phorbol 12-myristate 13-acetate (PMA) and chenodeoxycholic acid (CD) induced COX-2 protein expression in transformed, but not non-transformed cells.	Chenodeoxycholic Acid	85-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
11756226-7	2002	PMA-treated transformed and CYP2E1-expressing cells expressed functional COX-2 as demonstrated by marked inductions in prostaglandin E(2) synthesis.	Dinoprostone	119-137	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-78
11756226-8	2002	PMA-induced COX-2 expression in both transformed and CYP2E1-expressing cells resulted from an induction in COX-2 mRNA, and was dependent on extracellular signal-regulated kinase, p38 mitogen-activated protein kinase and phosphatidylinositol 3-kinase.	Tetradecanoylphorbol Acetate	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-17
11756226-8	2002	PMA-induced COX-2 expression in both transformed and CYP2E1-expressing cells resulted from an induction in COX-2 mRNA, and was dependent on extracellular signal-regulated kinase, p38 mitogen-activated protein kinase and phosphatidylinositol 3-kinase.	Tetradecanoylphorbol Acetate	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-112
12197220-2	2002	The detection frequency of COX-2 mRNA was 2-fold higher in bladder cancer patients compared to controls and it was accompanied by a significantly increased COX enzymatic activity and PGE2 synthesis (p &lt; 0.05).	Dinoprostone	183-187	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-32
12197220-5	2002	The observed over-expression of COX-2 gene in human urinary bladder and the concomitant increases in PG synthesis may explain, at least in part, the mechanism by which cigarette smoking influences the development of urothelial neoplasia.	Prostaglandins	101-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-37
11801560-2	2002	The purpose of this study was to investigate the cellular effects of acetylsalicylic acid (ASA), acetaminophen, and a COX-2 inhibitor (NS-398) on the growth of cell lines of human ovarian cancer in vitro.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	135-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-123
11801560-5	2002	RESULTS: A decrease in cell number compared with controls was observed for all of the cell lines treated with ASA, acetaminophen, and COX-2 inhibitor by cell count and tetrazolium conversion assay.	Tetrazolium Salts	168-179	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-139
11892711-3	2002	This study linked peroxynitrite (ONOO-) to the signaling pathways that induce COX-2.	Peroxynitrous Acid	18-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-83
11892711-3	2002	This study linked peroxynitrite (ONOO-) to the signaling pathways that induce COX-2.	oxido nitrite	33-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-83
11892711-4	2002	RESULTS: Exposure of rheumatoid synovial cells to peroxynitrite resulted in COX-2 protein expression in a dose-dependent manner.	Peroxynitrous Acid	50-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-81
11892711-5	2002	RT-PCR analysis also demonstrated that COX-2 mRNA was induced in peroxynitrite-treated rheumatoid synovial cells.	Peroxynitrous Acid	65-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-44
11892711-6	2002	Dexamethasone markedly inhibited this peroxynitrite-mediated COX-2 expression at therapeutic concentrations.	Dexamethasone	0-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-66
11892711-6	2002	Dexamethasone markedly inhibited this peroxynitrite-mediated COX-2 expression at therapeutic concentrations.	Peroxynitrous Acid	38-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-66
11945151-5	2002	The specific COX-2 inhibitors and acetaminophen are analgesic after dental surgery, orthopedic surgery and in osteoarthritis although acetaminophen appears to be a slightly weaker agent.	Acetaminophen	134-147	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
11945151-7	2002	Both groups of drugs also decrease the urinary excretion of prostacyclin metabolites consistent with inhibition of the systemic and renal activity of the COX-2 system.	Epoprostenol	60-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	154-159
11945151-8	2002	During repeated dosage with the specific COX-2 inhibitors, the 24 hour urinary excretion of sodium is only inhibited for the first day of treatment while the excretion of sodium is still decreased over the first 3 hours after the individual doses.	Sodium	92-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-46
11945151-8	2002	During repeated dosage with the specific COX-2 inhibitors, the 24 hour urinary excretion of sodium is only inhibited for the first day of treatment while the excretion of sodium is still decreased over the first 3 hours after the individual doses.	Sodium	171-177	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-46
11945152-9	2002	However it is premature to say that the benefit of Cox-2 inhibitors is lost in patients taking aspirin.	Aspirin	95-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-56
12017209-1	2002	OBJECTIVE: To evaluate the efficacy of 12 weeks of treatment with etoricoxib, a selective COX-2 inhibitor, in patients with osteoarthritis (OA) of the knee or hip.	Etoricoxib	66-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-95
12564662-3	2002	Valdecoxib, etoricoxib, DFU and DFP inhibited platelet COX-1 and monocyte COX-2 with the following COX-1/COX-2 IC50 ratios: 61.5, 344, 660 and 1918, respectively.	Etoricoxib	12-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-110
12060038-5	2002	COX-2 expression may be related to reflux of bile salts, which induce COX-2 expression in Barrett"s tissues and esophageal adenocarcinoma cells in vitro.	Bile Acids and Salts	45-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
12060038-5	2002	COX-2 expression may be related to reflux of bile salts, which induce COX-2 expression in Barrett"s tissues and esophageal adenocarcinoma cells in vitro.	Bile Acids and Salts	45-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-75
12224381-3	2002	In the present study, the effects of four previously synthesized tetrahydropyridines (THPs) on cyclooxygenase (COX)-1 and COX-2 were screened and the effects of these compounds on lipopolysaccharide (LPS)-induced (2 micrograms/ml) nitric oxide and inducible nitric oxide synthase (iNOS) activity in RAW 264.7 macrophages were examined.	Pyrrolidines	65-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-127
12224381-3	2002	In the present study, the effects of four previously synthesized tetrahydropyridines (THPs) on cyclooxygenase (COX)-1 and COX-2 were screened and the effects of these compounds on lipopolysaccharide (LPS)-induced (2 micrograms/ml) nitric oxide and inducible nitric oxide synthase (iNOS) activity in RAW 264.7 macrophages were examined.	Pyrrolidines	86-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-127
11850726-4	2002	COX-2 overexpression by malignant cells has been shown to enhance cellular invasion, induce angiogenesis, regulate anti-apoptotic cellular defenses and augment immunologic resistance through production of PGE-2.	Dinoprostone	205-210	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
12484230-0	2002	Colonic luminal contents (faecal water) induce COX-2.	Water	33-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
12086403-7	2002	A marked attenuation of NF-kappaB bindings and generation of free radicals was observed in COX-2 overexpressed cells.	Free Radicals	61-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-96
12086406-5	2002	The COX enzymatic system includes two isoenzymes, COX-1 and COX-2, that convert arachidonic acid to prostaglandins.	Arachidonic Acid	80-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-65
12086406-5	2002	The COX enzymatic system includes two isoenzymes, COX-1 and COX-2, that convert arachidonic acid to prostaglandins.	Prostaglandins	100-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-65
12086407-6	2002	When COX-2 is expressed, the CSF, granulocyte macrophage (GM)-CSF, and granulocyte (G)-CSF are exquisitely sensitive to endogenous PGs.	Phosphatidylglycerols	131-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	5-10
12086407-7	2002	In addition, the ability of COX-2 to suppress GM-CSF release is mediated via traditional IP/EP prostanoid receptors linked to cAMP-dependent pathways.	Cyclic AMP	126-130	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
18476013-0	2002	Biologically Active Co(II) and Ni(II) Complexes of N-(2-Thienylmethylene)-2-Aminothiadiazole.	n-(2-thienylmethylene)-2-aminothiadiazole	51-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-26
18476013-1	2002	Co(II) and Ni(II) complexes Schiff base, N-(2-thienylmethylene)-2-aminothiadiazole have been prepared and characterized by their physical, spectral and analytical data.	Schiff Bases	28-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
18476013-1	2002	Co(II) and Ni(II) complexes Schiff base, N-(2-thienylmethylene)-2-aminothiadiazole have been prepared and characterized by their physical, spectral and analytical data.	n-(2-thienylmethylene)-2-aminothiadiazole	41-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
18476013-2	2002	The title Schiff-base acts as NNS donor tridentate during the complexation reaction with these metal ions having a composition, [M(L)(2)]X(n) where M=Co(II) or Ni(II), L=, X=NO(3) (-), SO(4) (2-), C(2)O(4) (2-) or CH(3)CO(2) (-) and n=1 or 2 and show an octahedral geometry.	Schiff Bases	10-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	150-156
18476013-2	2002	The title Schiff-base acts as NNS donor tridentate during the complexation reaction with these metal ions having a composition, [M(L)(2)]X(n) where M=Co(II) or Ni(II), L=, X=NO(3) (-), SO(4) (2-), C(2)O(4) (2-) or CH(3)CO(2) (-) and n=1 or 2 and show an octahedral geometry.	nns	30-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	150-156
18476013-2	2002	The title Schiff-base acts as NNS donor tridentate during the complexation reaction with these metal ions having a composition, [M(L)(2)]X(n) where M=Co(II) or Ni(II), L=, X=NO(3) (-), SO(4) (2-), C(2)O(4) (2-) or CH(3)CO(2) (-) and n=1 or 2 and show an octahedral geometry.	Metals	95-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	150-156
12378813-0	2002	[Nimesulide (Aulin)--the selective COX-2 inhibitor in the treatment of ENT diseases].	nimesulide	1-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40
12378813-0	2002	[Nimesulide (Aulin)--the selective COX-2 inhibitor in the treatment of ENT diseases].	nimesulide	13-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40
11591701-2	2001	Cyclooxygenase (COX)-2 and COX-1 play an important role in prostacyclin production in vessels and participate in maintaining vascular homeostasis.	Epoprostenol	59-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-22
11591701-6	2001	Treatment of cells with 25 microm mevastatin or lovastatin resulted in the induction of COX-2 and increase in prostacyclin production.	mevastatin	34-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-93
11591701-6	2001	Treatment of cells with 25 microm mevastatin or lovastatin resulted in the induction of COX-2 and increase in prostacyclin production.	Lovastatin	48-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-93
11591701-8	2001	GGTI-286, a selective inhibitor of geranylgeranyltransferases, increased COX-2 expression and prostacyclin formation, thus indicating the involvement of geranylgeranylated proteins in the down-regulation of COX-2.	GGTI 286	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-78
11591701-8	2001	GGTI-286, a selective inhibitor of geranylgeranyltransferases, increased COX-2 expression and prostacyclin formation, thus indicating the involvement of geranylgeranylated proteins in the down-regulation of COX-2.	GGTI 286	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	207-212
11789101-9	2001	We have now been studying the COX-2 inhibitors rofecoxib (Vioxx) and celecoxib (Celebrex).	rofecoxib	47-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-35
11789101-9	2001	We have now been studying the COX-2 inhibitors rofecoxib (Vioxx) and celecoxib (Celebrex).	rofecoxib	58-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-35
11789101-9	2001	We have now been studying the COX-2 inhibitors rofecoxib (Vioxx) and celecoxib (Celebrex).	Celecoxib	80-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-35
11717412-2	2001	However, clinical studies have shown that the Cox-2 selective drugs (or coxibs) rofecoxib and etoricoxib, at therapeutic doses, do not interfere with the antiplatelet effect of aspirin, in contrast to ibuprofen.	rofecoxib	80-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
11679258-2	2001	Four different monoclonal antibodies specific for complexes of EDTA-Cd(II), DTPA-Co(II), 2,9-dicarboxyl-1,10-phenanthroline-U(VI), or cyclohexyl-DTPA-Pb(II) were incubated with the appropriate soluble metal-chelate complex.	Pentetic Acid	76-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-87
11751489-9	2001	Chenodeoxycholate markedly induced COX-2 but not mPGES in colorectal cancer cells.	Chenodeoxycholic Acid	0-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40
11751489-12	2001	Taken together, our results suggest that overexpression of mPGES in addition to COX-2 contributes to increased amounts of PGE(2) in colorectal adenomas and cancer.	Prostaglandins E	122-126	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-85
11726530-4	2001	UFAs inhibit COX-2 expression induced by SFAs and LPS.	Fatty Acids, Unsaturated	0-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
11729113-1	2001	BACKGROUND &amp; AIMS: Recent studies have shown that cyclooxygenase (COX)-2 and its products, prostaglandins (PGs), may be involved in colorectal carcinogenesis.	Adenosine Monophosphate	12-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-76
11729113-1	2001	BACKGROUND &amp; AIMS: Recent studies have shown that cyclooxygenase (COX)-2 and its products, prostaglandins (PGs), may be involved in colorectal carcinogenesis.	Prostaglandins	95-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-76
11729113-1	2001	BACKGROUND &amp; AIMS: Recent studies have shown that cyclooxygenase (COX)-2 and its products, prostaglandins (PGs), may be involved in colorectal carcinogenesis.	Prostaglandins	111-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-76
11729115-11	2001	CONCLUSIONS: Prostaglandins, through the induction of COX-2, are major participants in rodent postoperative ileus induced by intestinal manipulation.	Prostaglandins	13-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-59
12164389-2	2001	Here we report the synthesis and inhibition studies against the physiologically relevant isozymes CA I, CA II and CA IV, of a series of metal complexes (Co(II), Ni(II) and Cu(II) derivatives) of a Schiff-base ligand, obtained from sulfanilamide and salicylaldehyde.	Metals	136-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	153-159
12164389-2	2001	Here we report the synthesis and inhibition studies against the physiologically relevant isozymes CA I, CA II and CA IV, of a series of metal complexes (Co(II), Ni(II) and Cu(II) derivatives) of a Schiff-base ligand, obtained from sulfanilamide and salicylaldehyde.	Schiff Bases	197-208	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	153-159
12164389-2	2001	Here we report the synthesis and inhibition studies against the physiologically relevant isozymes CA I, CA II and CA IV, of a series of metal complexes (Co(II), Ni(II) and Cu(II) derivatives) of a Schiff-base ligand, obtained from sulfanilamide and salicylaldehyde.	Sulfanilamide	231-244	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	153-159
12164389-2	2001	Here we report the synthesis and inhibition studies against the physiologically relevant isozymes CA I, CA II and CA IV, of a series of metal complexes (Co(II), Ni(II) and Cu(II) derivatives) of a Schiff-base ligand, obtained from sulfanilamide and salicylaldehyde.	salicylaldehyde	249-264	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	153-159
11850206-5	2001	Since prostaglandin E2 is known to regulate aromatase gene expression and is the product of COX-2, an enzyme frequently overexpressed in tumors, immunocytochemistry was performed on the tissue sections using a polyclonal antibody to COX-2.	Dinoprostone	6-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-97
11850206-5	2001	Since prostaglandin E2 is known to regulate aromatase gene expression and is the product of COX-2, an enzyme frequently overexpressed in tumors, immunocytochemistry was performed on the tissue sections using a polyclonal antibody to COX-2.	Dinoprostone	6-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	233-238
11850206-7	2001	These results suggest that PGE2 produced by COX-2 in the tumor may be important in stimulating estrogen synthesis in the tumor and surrounding tissue.	Dinoprostone	27-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-49
11850210-4	2001	The prostaglandin E2 (PGE2) increases intracellular cAMP levels and stimulates estrogen biosynthesis, and our recent studies have shown a strong linear association between CYP19 expression and the sum of COX-1 and COX-2 expression in breast cancer specimens.	Dinoprostone	4-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	214-219
11850210-4	2001	The prostaglandin E2 (PGE2) increases intracellular cAMP levels and stimulates estrogen biosynthesis, and our recent studies have shown a strong linear association between CYP19 expression and the sum of COX-1 and COX-2 expression in breast cancer specimens.	Dinoprostone	22-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	214-219
11700032-4	2001	In human primary cultured decidual cells, a p38 inhibitor, SB202190, significantly inhibited both prostaglandin F(2alpha) production and COX-2 expression induced by stimulation with IL-1beta.	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	59-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-142
11688989-7	2001	Also, a COX-2 inhibitor, niflumic acid, inhibited the PG-LXR/LTB(4)DH eicosanoid oxidoreductase (EOR) by 80% while other COX-2 inhibitors such as nimesulide and NS-398 did not inhibit this enzyme.	Niflumic Acid	25-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	8-13
11688989-7	2001	Also, a COX-2 inhibitor, niflumic acid, inhibited the PG-LXR/LTB(4)DH eicosanoid oxidoreductase (EOR) by 80% while other COX-2 inhibitors such as nimesulide and NS-398 did not inhibit this enzyme.	Niflumic Acid	25-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-126
11688989-7	2001	Also, a COX-2 inhibitor, niflumic acid, inhibited the PG-LXR/LTB(4)DH eicosanoid oxidoreductase (EOR) by 80% while other COX-2 inhibitors such as nimesulide and NS-398 did not inhibit this enzyme.	nimesulide	146-156	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	8-13
11688989-7	2001	Also, a COX-2 inhibitor, niflumic acid, inhibited the PG-LXR/LTB(4)DH eicosanoid oxidoreductase (EOR) by 80% while other COX-2 inhibitors such as nimesulide and NS-398 did not inhibit this enzyme.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	161-167	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	8-13
11681893-1	2001	The electro-oxidation of cobalt (II) octaethylporphyrin adsorbed on graphite electrodes, Co(II)(OEP)(ads") to Co(III)(OEP)(ads)(+), in the presence of aqueous solutions of CO leads to catalytic oxidation of CO to CO(2).	cobalt (ii) octaethylporphyrin	25-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-95
11681893-1	2001	The electro-oxidation of cobalt (II) octaethylporphyrin adsorbed on graphite electrodes, Co(II)(OEP)(ads") to Co(III)(OEP)(ads)(+), in the presence of aqueous solutions of CO leads to catalytic oxidation of CO to CO(2).	cobalt (ii) octaethylporphyrin	25-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-99
11681893-1	2001	The electro-oxidation of cobalt (II) octaethylporphyrin adsorbed on graphite electrodes, Co(II)(OEP)(ads") to Co(III)(OEP)(ads)(+), in the presence of aqueous solutions of CO leads to catalytic oxidation of CO to CO(2).	cobalt (ii) octaethylporphyrin	25-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-121
11681893-1	2001	The electro-oxidation of cobalt (II) octaethylporphyrin adsorbed on graphite electrodes, Co(II)(OEP)(ads") to Co(III)(OEP)(ads)(+), in the presence of aqueous solutions of CO leads to catalytic oxidation of CO to CO(2).	Graphite	68-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-99
11681893-1	2001	The electro-oxidation of cobalt (II) octaethylporphyrin adsorbed on graphite electrodes, Co(II)(OEP)(ads") to Co(III)(OEP)(ads)(+), in the presence of aqueous solutions of CO leads to catalytic oxidation of CO to CO(2).	Graphite	68-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-121
11681893-1	2001	The electro-oxidation of cobalt (II) octaethylporphyrin adsorbed on graphite electrodes, Co(II)(OEP)(ads") to Co(III)(OEP)(ads)(+), in the presence of aqueous solutions of CO leads to catalytic oxidation of CO to CO(2).	co(iii)	110-117	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-95
11681893-1	2001	The electro-oxidation of cobalt (II) octaethylporphyrin adsorbed on graphite electrodes, Co(II)(OEP)(ads") to Co(III)(OEP)(ads)(+), in the presence of aqueous solutions of CO leads to catalytic oxidation of CO to CO(2).	co(iii)	110-117	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-99
11681893-1	2001	The electro-oxidation of cobalt (II) octaethylporphyrin adsorbed on graphite electrodes, Co(II)(OEP)(ads") to Co(III)(OEP)(ads)(+), in the presence of aqueous solutions of CO leads to catalytic oxidation of CO to CO(2).	co(iii)	110-117	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-121
11909555-4	2002	Thus, selective COX-2 inhibitors, or coxibs, were designed to inhibit only the production of COX-2-dependent inflammatory prostaglandins, without any effect on COX-1 and its gastroprotective function.	Prostaglandins	122-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-21
11909555-4	2002	Thus, selective COX-2 inhibitors, or coxibs, were designed to inhibit only the production of COX-2-dependent inflammatory prostaglandins, without any effect on COX-1 and its gastroprotective function.	Prostaglandins	122-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-98
11782374-1	2002	The inducible isoforms of nitric oxide synthase (iNOS) and cyclooxygenase (COX-2) are overexpressed in colonic tumors of humans, as well as in colon tumors that develop in rats after the administration of the colon-specific carcinogen, azoxymethane (AOM).	Azoxymethane	236-248	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
11782374-1	2002	The inducible isoforms of nitric oxide synthase (iNOS) and cyclooxygenase (COX-2) are overexpressed in colonic tumors of humans, as well as in colon tumors that develop in rats after the administration of the colon-specific carcinogen, azoxymethane (AOM).	Azoxymethane	250-253	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
12086291-9	2002	Clinical studies of the COX-2-selective inhibitors rofecoxib and celecoxib have demonstrated efficacy equivalent to nonselective NSAIDs with lower rates of GI side effects (for example, incidence of endoscopic ulcers equivalent to placebo).	rofecoxib	51-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
12086291-9	2002	Clinical studies of the COX-2-selective inhibitors rofecoxib and celecoxib have demonstrated efficacy equivalent to nonselective NSAIDs with lower rates of GI side effects (for example, incidence of endoscopic ulcers equivalent to placebo).	Celecoxib	65-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
12086293-4	2002	The gastrointestinal toxicity of nonselective NSAIDs and aspirin derives from the inhibition of the cyclooxygenase (COX) enzyme, COX-1, which synthesizes gastroprotective prostaglandins, while the anti-inflammatory and pain-relieving effects are largely derived from inhibition of COX-2-derived prostaglandins.	Aspirin	57-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	281-286
12086293-4	2002	The gastrointestinal toxicity of nonselective NSAIDs and aspirin derives from the inhibition of the cyclooxygenase (COX) enzyme, COX-1, which synthesizes gastroprotective prostaglandins, while the anti-inflammatory and pain-relieving effects are largely derived from inhibition of COX-2-derived prostaglandins.	Prostaglandins	171-185	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	281-286
12086293-6	2002	The COX-2-selective inhibitors, however, have also been shown to inhibit the production of vascular prostacyclin, which has vasodilatory effects and inhibits platelet aggregation; unlike nonselective NSAIDs, they do not inhibit the production of thromboxane, an eicosanoid that promotes platelet aggregation.	Epoprostenol	100-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
12086293-6	2002	The COX-2-selective inhibitors, however, have also been shown to inhibit the production of vascular prostacyclin, which has vasodilatory effects and inhibits platelet aggregation; unlike nonselective NSAIDs, they do not inhibit the production of thromboxane, an eicosanoid that promotes platelet aggregation.	Thromboxanes	246-257	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
12086293-6	2002	The COX-2-selective inhibitors, however, have also been shown to inhibit the production of vascular prostacyclin, which has vasodilatory effects and inhibits platelet aggregation; unlike nonselective NSAIDs, they do not inhibit the production of thromboxane, an eicosanoid that promotes platelet aggregation.	Eicosanoids	262-272	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
12086294-3	2002	The intermediate enzymes responsible for prostaglandin biosynthesis, cyclooxygenase (COX)-1 and COX-2, have been the target of arthritis therapy using nonselective nonsteroidal anti-inflammatory drugs (NSAIDs).	Prostaglandins	41-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-101
12086297-9	2002	This evidence supports a role for COX-2-derived prostaglandins as key mediators of nociceptive pain and peripheral sensitization (hyperalgesia).	Prostaglandins	48-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-39
12498388-6	2002	Both indomethacin (a nonspecific COX inhibitor) and NS-398 (a specific COX-2 inhibitor) inhibited the production of prostaglandins and the cell invasion.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	52-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-76
12498388-6	2002	Both indomethacin (a nonspecific COX inhibitor) and NS-398 (a specific COX-2 inhibitor) inhibited the production of prostaglandins and the cell invasion.	Prostaglandins	116-130	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-76
12498388-10	2002	These results suggest that in the PC-3 Low Invasive cells, COX-2-derived PGE2 may not be sufficient to induce cell invasion while in the PC-3 High Invasive cells, PGE2 may be sufficient to act as an enhancer for the cell invasion.	Dinoprostone	73-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-64
12017215-2	2002	Rofecoxib, an agent that selectively inhibits COX-2, has been shown to provide equivalent anti-inflammatory and analgesic efficacy to comparator non-selective NSAIDs in osteoarthritis (OA) and other pain models with a significant improvement in gastrointestinal (GI) safety and tolerability.	rofecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
12564662-3	2002	Valdecoxib, etoricoxib, DFU and DFP inhibited platelet COX-1 and monocyte COX-2 with the following COX-1/COX-2 IC50 ratios: 61.5, 344, 660 and 1918, respectively.	valdecoxib	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
12564662-3	2002	Valdecoxib, etoricoxib, DFU and DFP inhibited platelet COX-1 and monocyte COX-2 with the following COX-1/COX-2 IC50 ratios: 61.5, 344, 660 and 1918, respectively.	valdecoxib	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-110
12564662-3	2002	Valdecoxib, etoricoxib, DFU and DFP inhibited platelet COX-1 and monocyte COX-2 with the following COX-1/COX-2 IC50 ratios: 61.5, 344, 660 and 1918, respectively.	Etoricoxib	12-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
11945113-5	2002	The recent introduction of selective COX-2 inhibitors, celecoxib and rofecoxib, appear to induce less gastrointestinal morbidity.	Celecoxib	55-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-42
11945113-5	2002	The recent introduction of selective COX-2 inhibitors, celecoxib and rofecoxib, appear to induce less gastrointestinal morbidity.	rofecoxib	69-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-42
12466002-1	2002	Etoricoxib is a cyclo-oxygenase (COX)-2-selective NSAID with a higher COX-1 to COX-2 selectivity ratio than the other COX-2-selective NSAIDs rofecoxib, valdecoxib or celecoxib.	Etoricoxib	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-84
12450219-4	2002	We show here that human COX-2 expression in APP(swe)/PS1/COX-2 mice induces potentiation of brain parenchymal amyloid plaque formation and a greater than twofold increase in prostaglandin E2 production, at 24 months of age.	Dinoprostone	174-190	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
12450219-4	2002	We show here that human COX-2 expression in APP(swe)/PS1/COX-2 mice induces potentiation of brain parenchymal amyloid plaque formation and a greater than twofold increase in prostaglandin E2 production, at 24 months of age.	Dinoprostone	174-190	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-62
11866383-1	2002	Rofecoxib is a selective cyclooxygenase (COX)-2 inhibitor that is approved for the treatment of acute pain and osteoarthritis in adults.	rofecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-47
12086397-6	2002	Pretreatment with NS-398, a selective COX-2 inhibitor, or indomethacin, a nonselective COX inhibitor, significantly enhanced the Cap-induced decreased cell viability and apoptosis.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	18-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-43
12086397-6	2002	Pretreatment with NS-398, a selective COX-2 inhibitor, or indomethacin, a nonselective COX inhibitor, significantly enhanced the Cap-induced decreased cell viability and apoptosis.	Capsaicin	129-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-43
11853083-11	2002	Taken together, we conclude that the increased production of prostaglandins by osteoid osteomas implicates that COX-2 is one of the mediators of this condition.	Prostaglandins	61-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-117
11810043-4	2002	COX-2 expression may contribute to the synthesis of prostanoids, which relate to carcinogenesis and tumor progression.	Prostaglandins	52-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
16228501-5	2002	In contrast, the Co(II) complex, as well as the Mg/Zn/Cd(II) complexes, self-aggregated in 1% (v/v) tetrahydrofuran-hexane to form oligomers.	hexane THF	100-122	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-23
11952135-3	2002	Cyclooxygenase (COX), the key enzyme in transforming AA into PGs, has two isoforms: COX-1 is constitutively expressed, and COX-2, is inducible.	Prostaglandins	61-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-128
11819915-9	2001	Corticoids reduce the production of prostanoids by inhibiting the expression of COX-2, but are much less effective on the production of leukotrienes.	Prostaglandins	36-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-85
11819916-10	2001	MODE OF ACTION: NSAID have a common effect, inhibiting the production of prostanoids via reduced activity of two cyclo-oxygenases (COX-1 and COX-2).	Prostaglandins	73-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	141-146
11819916-12	2001	Excepting two compounds recently marketed (celecoxib, rofecoxib) selective for COX-2, all other NSAID have few or no selective properties.	Celecoxib	43-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-84
11819916-12	2001	Excepting two compounds recently marketed (celecoxib, rofecoxib) selective for COX-2, all other NSAID have few or no selective properties.	rofecoxib	54-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-84
11742239-2	2001	We examined whether the selective COX-2 inhibitor NS398 would protect neuronal function after global hypoxia/ischemia (H/I) in piglets.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	50-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-39
11742239-11	2001	In conclusion, COX-2 appears to be a major source of ROS in the piglet cerebral cortex after H/I.	Reactive Oxygen Species	53-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-20
11775144-12	2001	XANES spectral analysis indicated that most Co(II) was oxidized to Co(III) and probably incorporated structurally into manganese oxides.	xanes	0-5	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-50
11775144-12	2001	XANES spectral analysis indicated that most Co(II) was oxidized to Co(III) and probably incorporated structurally into manganese oxides.	manganese oxide	119-135	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-50
11717412-8	2001	These results show that a low affinity for Cox-1 and a high degree of Cox-2 selectivity confers a low potential to block aspirin inhibition of platelet Cox-1, consistent with the results of clinical studies.	Aspirin	121-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-75
11751448-2	2001	Curcumin, a polyphenol derived from Curcuma spp., has shown wide-ranging chemopreventive activity in preclinical carcinogenic models, in which it inhibits cyclooxygenase (COX)-2 at the transcriptional level.	Curcumin	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	155-177
11751448-5	2001	When 1 microM curcumin was added in vitro to blood from healthy volunteers, LPS-induced COX-2 protein levels and concomitant PGE(2) production were reduced by 24% and 41%, respectively (P &lt; 0.05 by ANOVA).	Curcumin	14-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-93
11742186-4	2001	The COX-2 selective NSAID, rofecoxib, is in comparison with naproxen, a non-selective NSAID, associated with fewer clinically important upper gastrointestinal events.	rofecoxib	27-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
11742186-6	2001	Co-administration of the COX-2 selective NSAID, celecoxib, and low-dose aspirin, is associated with the same risk for upper gastrointestinal ulcer complications alone and combined with symptomatic ulcers, as the non-selective NSAIDs, ibuprofen and diclofenac.	Celecoxib	48-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-30
11742186-6	2001	Co-administration of the COX-2 selective NSAID, celecoxib, and low-dose aspirin, is associated with the same risk for upper gastrointestinal ulcer complications alone and combined with symptomatic ulcers, as the non-selective NSAIDs, ibuprofen and diclofenac.	Aspirin	72-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-30
11742186-6	2001	Co-administration of the COX-2 selective NSAID, celecoxib, and low-dose aspirin, is associated with the same risk for upper gastrointestinal ulcer complications alone and combined with symptomatic ulcers, as the non-selective NSAIDs, ibuprofen and diclofenac.	Ibuprofen	234-243	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-30
11742186-6	2001	Co-administration of the COX-2 selective NSAID, celecoxib, and low-dose aspirin, is associated with the same risk for upper gastrointestinal ulcer complications alone and combined with symptomatic ulcers, as the non-selective NSAIDs, ibuprofen and diclofenac.	Diclofenac	248-258	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-30
11764538-4	2001	With the advent of selective COX-2 inhibitors, it has become possible to dissect further the roles of prostaglandins in mucosal defense.	Prostaglandins	102-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34
11764538-5	2001	The weight of evidence collected so far suggests that prostaglandins derived from COX-2 are important in promoting the healing of mucosal injury, in protecting against bacterial invasion, and in down-regulating the mucosal immune system.	Prostaglandins	54-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
12002912-6	2001	Here, we have investigated the effects of COX-metabolites, such as PGI2, PGE2, PGF2alpha and U44069, on the induction of COX-2 in human umbilical vein endothelial cells (HUVEC) treated with LPS (1 microg/ml).	Epoprostenol	67-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-126
12002912-6	2001	Here, we have investigated the effects of COX-metabolites, such as PGI2, PGE2, PGF2alpha and U44069, on the induction of COX-2 in human umbilical vein endothelial cells (HUVEC) treated with LPS (1 microg/ml).	Dinoprostone	73-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-126
12002912-6	2001	Here, we have investigated the effects of COX-metabolites, such as PGI2, PGE2, PGF2alpha and U44069, on the induction of COX-2 in human umbilical vein endothelial cells (HUVEC) treated with LPS (1 microg/ml).	Dinoprost	79-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-126
12002912-13	2001	Similarly, COX-2 protein expression in LPS treated HUVEC was also inhibited with PGE2, but not PG2, PGF2alpha or U44069, in a dose dependent manner.	Dinoprostone	81-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-16
12002912-13	2001	Similarly, COX-2 protein expression in LPS treated HUVEC was also inhibited with PGE2, but not PG2, PGF2alpha or U44069, in a dose dependent manner.	Dinoprost	100-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-16
11723253-3	2001	Both agents inhibited the TNF-alpha- or TPA-induced expression of cyclooxygenase (COX)-2 mRNA and protein, COX-2 promoter activity, and prostaglandin E2 (PGE2) production.	Tetradecanoylphorbol Acetate	40-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-88
11723253-3	2001	Both agents inhibited the TNF-alpha- or TPA-induced expression of cyclooxygenase (COX)-2 mRNA and protein, COX-2 promoter activity, and prostaglandin E2 (PGE2) production.	Tetradecanoylphorbol Acetate	40-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-112
11723253-6	2001	These results suggest that the inhibitory effect of GF-015 and GF-90 on TNF-alpha-induced COX-2 protein expression was caused by suppression of IKK activity and NF-kappaB activation in the COX-2 promoter, resulting in attenuation of COX-2 gene expression and PGE2 production.	Dinoprostone	259-263	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-95
11723253-6	2001	These results suggest that the inhibitory effect of GF-015 and GF-90 on TNF-alpha-induced COX-2 protein expression was caused by suppression of IKK activity and NF-kappaB activation in the COX-2 promoter, resulting in attenuation of COX-2 gene expression and PGE2 production.	Dinoprostone	259-263	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	189-194
11723253-6	2001	These results suggest that the inhibitory effect of GF-015 and GF-90 on TNF-alpha-induced COX-2 protein expression was caused by suppression of IKK activity and NF-kappaB activation in the COX-2 promoter, resulting in attenuation of COX-2 gene expression and PGE2 production.	Dinoprostone	259-263	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	189-194
11735348-6	2001	A most promising approach seemed to be the preparation of novel NSAIDs, targeted at the inducible isoform of prostaglandin synthase (COX-2); they appear to be devoid of gastrointestinal toxicity, in that they spare mucosal prostaglandin synthesis.	Prostaglandins	109-122	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	133-138
11735348-7	2001	However, a number of recent studies have raised serious questions about the two central tenets that support this approach, namely that the prostaglandins that mediate inflammation and pain are produced solely via COX-2 and that the prostaglandins that are important in gastrointestinal and renal function are produced solely via COX-1.	Prostaglandins	139-153	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	213-218
11735348-9	2001	More recent and puzzling data shows that COX-2 is induced during the resolution of an inflammatory response, and at this point it produces anti-inflammatory (PGD2 and PGF2alpha), but not proinflammatory (PGE2) prostaglandins; inhibition of COX-2 at this point thus results in persistence of the inflammation.	Prostaglandin D2	158-162	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-46
11735348-9	2001	More recent and puzzling data shows that COX-2 is induced during the resolution of an inflammatory response, and at this point it produces anti-inflammatory (PGD2 and PGF2alpha), but not proinflammatory (PGE2) prostaglandins; inhibition of COX-2 at this point thus results in persistence of the inflammation.	Dinoprost	167-176	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-46
11735348-9	2001	More recent and puzzling data shows that COX-2 is induced during the resolution of an inflammatory response, and at this point it produces anti-inflammatory (PGD2 and PGF2alpha), but not proinflammatory (PGE2) prostaglandins; inhibition of COX-2 at this point thus results in persistence of the inflammation.	Dinoprostone	204-208	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-46
11735348-9	2001	More recent and puzzling data shows that COX-2 is induced during the resolution of an inflammatory response, and at this point it produces anti-inflammatory (PGD2 and PGF2alpha), but not proinflammatory (PGE2) prostaglandins; inhibition of COX-2 at this point thus results in persistence of the inflammation.	Prostaglandins	210-224	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-46
11735348-10	2001	Moreover, COX-2 selective NSAIDs have lost the cardiovascular protective effects of non-selective NSAIDs, effects which are mediated through COX-1 inhibition (in addition, COX-2 has a role in sustaining vascular prostacyclin production).	Epoprostenol	212-224	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
11735348-10	2001	Moreover, COX-2 selective NSAIDs have lost the cardiovascular protective effects of non-selective NSAIDs, effects which are mediated through COX-1 inhibition (in addition, COX-2 has a role in sustaining vascular prostacyclin production).	Epoprostenol	212-224	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	172-177
11770048-2	2001	The cyclooxygenase (COX) product prostaglandin (PG) E2 appears to be central to this process, however, non-selective inhibition of COX activity with non-steroidal anti-inflammatory agents that block both the constitutive (COX-1) and inducible (COX-2) isoforms of cyclooxygenase has not yielded promising results in trauma patients.	Dinoprostone	33-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	244-249
11717429-4	2001	In cells, SP600125 dose dependently inhibited the phosphorylation of c-Jun, the expression of inflammatory genes COX-2, IL-2, IFN-gamma, TNF-alpha, and prevented the activation and differentiation of primary human CD4 cell cultures.	pyrazolanthrone	10-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-118
11701026-5	2001	Further applicability of this strategy is shown in the total syntheses of tetrahydrodicranenone B, rosaprostol, and a selective COX-2 inhibitor.	tetrahydrodicranenone B	74-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	128-133
11701026-5	2001	Further applicability of this strategy is shown in the total syntheses of tetrahydrodicranenone B, rosaprostol, and a selective COX-2 inhibitor.	rosaprostol	99-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	128-133
11696466-2	2001	Among the randomized, controlled trials with the COX-2 inhibitor rofecoxib, one study demonstrated a significant difference between rofecoxib and its NSAID comparator (naproxen) in the risk of CV thrombotic events.	rofecoxib	132-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-54
11696466-2	2001	Among the randomized, controlled trials with the COX-2 inhibitor rofecoxib, one study demonstrated a significant difference between rofecoxib and its NSAID comparator (naproxen) in the risk of CV thrombotic events.	Naproxen	168-176	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-54
11721898-1	2001	Using a heterogeneous catalyst, Co(II)-ethanolamine complex sorbed on Dowex-50W resin, the chemiluminescence (CL) of luminol in unbuffered or weakly acidic solution was studied in the presence of H2O2.	Ethanolamine	39-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-38
11721898-1	2001	Using a heterogeneous catalyst, Co(II)-ethanolamine complex sorbed on Dowex-50W resin, the chemiluminescence (CL) of luminol in unbuffered or weakly acidic solution was studied in the presence of H2O2.	Luminol	117-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-38
11681893-1	2001	The electro-oxidation of cobalt (II) octaethylporphyrin adsorbed on graphite electrodes, Co(II)(OEP)(ads") to Co(III)(OEP)(ads)(+), in the presence of aqueous solutions of CO leads to catalytic oxidation of CO to CO(2).	Carbon Monoxide	172-174	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-95
11681893-1	2001	The electro-oxidation of cobalt (II) octaethylporphyrin adsorbed on graphite electrodes, Co(II)(OEP)(ads") to Co(III)(OEP)(ads)(+), in the presence of aqueous solutions of CO leads to catalytic oxidation of CO to CO(2).	Carbon Monoxide	172-174	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-99
11681893-1	2001	The electro-oxidation of cobalt (II) octaethylporphyrin adsorbed on graphite electrodes, Co(II)(OEP)(ads") to Co(III)(OEP)(ads)(+), in the presence of aqueous solutions of CO leads to catalytic oxidation of CO to CO(2).	co(2)	213-218	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-95
11681893-1	2001	The electro-oxidation of cobalt (II) octaethylporphyrin adsorbed on graphite electrodes, Co(II)(OEP)(ads") to Co(III)(OEP)(ads)(+), in the presence of aqueous solutions of CO leads to catalytic oxidation of CO to CO(2).	co(2)	213-218	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-99
11681893-3	2001	Coordination of the CO to Co(III)(OEP)(+) is the first step in the catalytic mechanism.	Carbon Monoxide	20-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-37
11677234-2	2002	Prostaglandin synthesis by cyclooxygenases-1 and -2 (COX-1 and COX-2) involves an initial oxygenation of arachidonic acid at C-11, followed by endoperoxide and cyclopentane ring formation, and then a second reaction with molecular oxygen in the S configuration at C-15.	Cyclopentanes	160-172	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-68
11721898-7	2001	On the basis of the studies of the CL, fluorescence, UV-vis and ESCA spectra and the effect of dissolved oxygen in luminol solution, a mechanism for CL emission in unbuffered solution was considered as the formation of a superoxide radical ion during the decomposition of H2O2 catalyzed by the Co(II)-ethanolamine immobilized resin.	Superoxides	221-239	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	294-299
11677234-2	2002	Prostaglandin synthesis by cyclooxygenases-1 and -2 (COX-1 and COX-2) involves an initial oxygenation of arachidonic acid at C-11, followed by endoperoxide and cyclopentane ring formation, and then a second reaction with molecular oxygen in the S configuration at C-15.	Oxygen	32-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-68
11677234-6	2002	In COX-2, site-directed mutagenesis of Ser-530 to methionine, threonine, or valine produced highly active enzymes that formed 82-95% 15R-configuration prostaglandins; these have the opposite stereochemistry at C-15 to the natural products.	Prostaglandins	151-165	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	3-8
11677234-9	2002	When Val-349 was replaced by isoleucine, the mutant COX-1 and COX-2 enzymes formed 41 and 65% 15R-prostaglandins, respectively.	15r-prostaglandins	94-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
11763065-1	2001	The system Co(II)-phenylthiourea (PTU)-borax buffer was investigated by cathodic stripping voltammetry (CSV) at a hanging mercury drop electrode.	Mercury	122-129	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-17
11705450-8	2001	The enhancing effect of theaflavins on PGE(2) production was related to the COX-2 level in the microsomes.	theaflavin	24-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-81
11763065-2	2001	The results of the voltammetric measurements showed that the presence of both PTU and Co(II) gives rise to a new irreversible peak at about -1.5 V. Based upon our previous results obtained in the study of other sulfur compounds and the sulfide ion itself, the peak was ascribed to the catalytic hydrogen evolution superimposed on the reduction of the coordinated Co(II) ion.	ptu	78-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	363-369
11763065-2	2001	The results of the voltammetric measurements showed that the presence of both PTU and Co(II) gives rise to a new irreversible peak at about -1.5 V. Based upon our previous results obtained in the study of other sulfur compounds and the sulfide ion itself, the peak was ascribed to the catalytic hydrogen evolution superimposed on the reduction of the coordinated Co(II) ion.	Sulfur	211-217	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-92
11763065-2	2001	The results of the voltammetric measurements showed that the presence of both PTU and Co(II) gives rise to a new irreversible peak at about -1.5 V. Based upon our previous results obtained in the study of other sulfur compounds and the sulfide ion itself, the peak was ascribed to the catalytic hydrogen evolution superimposed on the reduction of the coordinated Co(II) ion.	Sulfides	236-243	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-92
11763065-2	2001	The results of the voltammetric measurements showed that the presence of both PTU and Co(II) gives rise to a new irreversible peak at about -1.5 V. Based upon our previous results obtained in the study of other sulfur compounds and the sulfide ion itself, the peak was ascribed to the catalytic hydrogen evolution superimposed on the reduction of the coordinated Co(II) ion.	Sulfides	236-243	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	363-369
11763065-2	2001	The results of the voltammetric measurements showed that the presence of both PTU and Co(II) gives rise to a new irreversible peak at about -1.5 V. Based upon our previous results obtained in the study of other sulfur compounds and the sulfide ion itself, the peak was ascribed to the catalytic hydrogen evolution superimposed on the reduction of the coordinated Co(II) ion.	Hydrogen	295-303	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-92
11763065-2	2001	The results of the voltammetric measurements showed that the presence of both PTU and Co(II) gives rise to a new irreversible peak at about -1.5 V. Based upon our previous results obtained in the study of other sulfur compounds and the sulfide ion itself, the peak was ascribed to the catalytic hydrogen evolution superimposed on the reduction of the coordinated Co(II) ion.	Hydrogen	295-303	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	363-369
11763065-3	2001	The catalyst itself is a Co(II) complex with the sulfide ion produced by the decomposition of the analyte during the deposition step.	Sulfides	49-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-31
11705450-8	2001	The enhancing effect of theaflavins on PGE(2) production was related to the COX-2 level in the microsomes.	Dinoprostone	39-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-81
11705450-9	2001	Although theaflavin inhibited ovine COX-2, its activity in the formation of PGE(2) was stimulated by theaflavin when ovine COX-2 was mixed with microsomes, suggesting that theaflavin affects the interaction of COX-2 with other microsomal factors (e.g. PGE synthase).	theaflavin	9-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-41
11705450-9	2001	Although theaflavin inhibited ovine COX-2, its activity in the formation of PGE(2) was stimulated by theaflavin when ovine COX-2 was mixed with microsomes, suggesting that theaflavin affects the interaction of COX-2 with other microsomal factors (e.g. PGE synthase).	Dinoprostone	76-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-128
11705450-9	2001	Although theaflavin inhibited ovine COX-2, its activity in the formation of PGE(2) was stimulated by theaflavin when ovine COX-2 was mixed with microsomes, suggesting that theaflavin affects the interaction of COX-2 with other microsomal factors (e.g. PGE synthase).	Dinoprostone	76-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-128
11705450-9	2001	Although theaflavin inhibited ovine COX-2, its activity in the formation of PGE(2) was stimulated by theaflavin when ovine COX-2 was mixed with microsomes, suggesting that theaflavin affects the interaction of COX-2 with other microsomal factors (e.g. PGE synthase).	theaflavin	101-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-128
11705450-9	2001	Although theaflavin inhibited ovine COX-2, its activity in the formation of PGE(2) was stimulated by theaflavin when ovine COX-2 was mixed with microsomes, suggesting that theaflavin affects the interaction of COX-2 with other microsomal factors (e.g. PGE synthase).	theaflavin	101-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-128
11705450-9	2001	Although theaflavin inhibited ovine COX-2, its activity in the formation of PGE(2) was stimulated by theaflavin when ovine COX-2 was mixed with microsomes, suggesting that theaflavin affects the interaction of COX-2 with other microsomal factors (e.g. PGE synthase).	theaflavin	101-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-128
11705450-9	2001	Although theaflavin inhibited ovine COX-2, its activity in the formation of PGE(2) was stimulated by theaflavin when ovine COX-2 was mixed with microsomes, suggesting that theaflavin affects the interaction of COX-2 with other microsomal factors (e.g. PGE synthase).	theaflavin	101-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-128
11779086-9	2001	The selective COX-2 inhibitor celecoxib (Celebrex, Pharmacia) has been shown to reduce the number of adenomatous colorectal polyps in familial adenomatous polyposis as an adjunct to usual care.	Celecoxib	30-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
11779086-9	2001	The selective COX-2 inhibitor celecoxib (Celebrex, Pharmacia) has been shown to reduce the number of adenomatous colorectal polyps in familial adenomatous polyposis as an adjunct to usual care.	Celecoxib	41-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
11695246-2	2001	The cyclooxygenase (COX)-2 selective inhibitors celecoxib and rofecoxib have been found to be more effective than placebo and comparably effective to nonselective nonsteroidal anti-inflammatory drugs (NSAIDs) in the treatment of patients with osteoarthritis and rheumatoid arthritis.	Celecoxib	48-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-26
11695251-1	2001	The isozymes cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) catalyze the conversion of arachidonic acid to eicosanoids that play an important role in the maintenance of cardiovascular hemostasis.	Eicosanoids	114-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-65
11695246-2	2001	The cyclooxygenase (COX)-2 selective inhibitors celecoxib and rofecoxib have been found to be more effective than placebo and comparably effective to nonselective nonsteroidal anti-inflammatory drugs (NSAIDs) in the treatment of patients with osteoarthritis and rheumatoid arthritis.	rofecoxib	62-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-26
11695251-3	2001	In contrast, vascular prostaglandin I2 (PGI2), which appears to be synthesized by COX-2, counteracts most of these effects of TxA2.	Epoprostenol	22-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
11695246-3	2001	Two large outcome studies, the Celecoxib Long-term Arthritis Safety Study (CLASS) and Vioxx Gastrointestinal Outcomes Research (VIGOR) trial, were conducted to test the hypothesis that patients receiving a COX-2 selective inhibitor would have significantly fewer clinically important upper gastrointestinal events than patients taking nonselective NSAIDs.	rofecoxib	86-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	206-211
11695251-3	2001	In contrast, vascular prostaglandin I2 (PGI2), which appears to be synthesized by COX-2, counteracts most of these effects of TxA2.	Epoprostenol	40-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
11695246-8	2001	Further studies are needed to determine whether COX-2 selective inhibitors are safer than nonselective NSAIDs when used in patients receiving low-dose aspirin.	Aspirin	151-158	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-53
11695253-6	2001	Following the discovery of the two differentially distributed and regulated COXs, two non-acidic COX-2-selective compounds--celecoxib and rofecoxib--were introduced.	Celecoxib	124-133	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
11695251-1	2001	The isozymes cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) catalyze the conversion of arachidonic acid to eicosanoids that play an important role in the maintenance of cardiovascular hemostasis.	Arachidonic Acid	94-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-65
11695253-6	2001	Following the discovery of the two differentially distributed and regulated COXs, two non-acidic COX-2-selective compounds--celecoxib and rofecoxib--were introduced.	rofecoxib	138-147	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
11695253-11	2001	We therefore propose that a drug combining the pharmacokinetic characteristics of, for example, ibuprofen with the COX-2 selectivity of rofecoxib is likely to be a superior anti-inflammatory analgesic.	rofecoxib	136-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-120
11695255-2	2001	A series of studies is reviewed that assesses the relationship between cytokines released at the site of tissue injury and NSAID analgesia, and the in vivo selectivity of a selective cyclooxygenase (COX)-2 inhibitor (celecoxib) in comparison to a dual COX-1/COX-2 inhibitor (ketorolac).	Celecoxib	217-226	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	183-205
11771569-8	2001	In conclusion, dexibuprofen (Seractil) has the stature of a modern NSAID, combining the high efficacy of diclofenac with the good tolerability of ibuprofen, and need not hide behind the new generation of COX-2 inhibitors.	dexibuprofen	15-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	204-209
11695255-4	2001	The time course of PGE2 production was consistent with early release due to COX-1 activity followed by increased production 2-3 hours after surgery, consistent with COX-2 expression.	Dinoprostone	19-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	165-170
11695255-7	2001	Celecoxib selectively suppressed PGE2 but not TxB2 at time points consistent with COX-2 activity, while producing analgesia.	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
11695255-8	2001	These studies demonstrate the ability to assess the time course and selective effects of COX-2 inhibitors in vivo and suggest that suppression of COX-2 mediated PGE2 is temporally related to NSAID analgesia.	Dinoprostone	161-165	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-94
11695255-8	2001	These studies demonstrate the ability to assess the time course and selective effects of COX-2 inhibitors in vivo and suggest that suppression of COX-2 mediated PGE2 is temporally related to NSAID analgesia.	Dinoprostone	161-165	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	146-151
11771569-8	2001	In conclusion, dexibuprofen (Seractil) has the stature of a modern NSAID, combining the high efficacy of diclofenac with the good tolerability of ibuprofen, and need not hide behind the new generation of COX-2 inhibitors.	Ibuprofen	18-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	204-209
11825322-3	2001	Since the discovery of two PG synthesising enzymes, COX-1 and COX-2, and the substantial evidence that sparing COX-1 is advantageous for gastric safety, great interest has focused on selective COX-2 inhibitors.	Prostaglandins	27-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	193-198
11706832-0	2001	Discussion on rofecoxib, a COX-2 inhibitor, does not inhibit human gastric mucosal prostaglandin production.	rofecoxib	14-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-32
11825322-5	2001	However, the older drugs etodolac, nimesulide and meloxicam, made before COX-2 was discovered, are also COX-1-sparing and have good GI safety and therapeutic activities.	Etodolac	25-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-78
11825322-5	2001	However, the older drugs etodolac, nimesulide and meloxicam, made before COX-2 was discovered, are also COX-1-sparing and have good GI safety and therapeutic activities.	nimesulide	35-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-78
11825322-5	2001	However, the older drugs etodolac, nimesulide and meloxicam, made before COX-2 was discovered, are also COX-1-sparing and have good GI safety and therapeutic activities.	Meloxicam	50-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-78
11701743-3	2001	Cyclooxygenase (Cox) is the key enzyme in conversion of arachidonic acid to PGs, and two isoforms, Cox-1 and Cox-2, have been identified.	Arachidonic Acid	56-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-114
11701743-3	2001	Cyclooxygenase (Cox) is the key enzyme in conversion of arachidonic acid to PGs, and two isoforms, Cox-1 and Cox-2, have been identified.	Phosphatidylglycerols	76-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-114
11827414-12	2001	Indomethacin inhibited the synthesis of PGE2 in all three cell lines, although the level of Cox-2 mRNA tended to increase by indomethacin.	Indomethacin	125-137	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-97
11723170-9	2001	The time course of COX-2 up-regulation suggests that the formalin-induced nociceptive response precedes COX-2 protein de novo synthesis and may therefore be unresponsive to COX-2 inhibition.	Formaldehyde	57-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-24
11641439-3	2001	PMA elicited an inhibitory effect on PDE4D5 activity in HASMC treated with the cyclooxygenase (COX) inhibitor indomethacin, the COX-2 selective inhibitor NS-398, the phospholipase A(2) inhibitor quinacrine, and the cAMP-dependent protein kinase A (PKA) inhibitor H89.	Tetradecanoylphorbol Acetate	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	128-133
11578780-8	2001	Moreover, the PPAR alpha agonist WY14643 inhibited macrophage differentiation and COX-2 gene expression.	pirinixic acid	33-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
11605058-6	2001	In this study, we demonstrated that induction of apoptosis of high COX-2-expressing A549 lung cancer cells by a specific COX-2 inhibitor NS398 was observed in cells cultured under serum-free condition.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	137-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-72
11605058-6	2001	In this study, we demonstrated that induction of apoptosis of high COX-2-expressing A549 lung cancer cells by a specific COX-2 inhibitor NS398 was observed in cells cultured under serum-free condition.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	137-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-126
11605058-8	2001	Conversely, low COX-2-expressing H226 lung cancer cells were resistant to NS398-induced apoptosis under both serum-free and serum-containing conditions.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	74-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-21
11672759-12	2001	This may be due to synthesis of TXA(2) by the inducible COX-2 enzyme and/or to a transcellular metabolism in platelets of prostanoids generated by endothelial cells.	txa	32-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-61
11817175-0	2001	In vitro study of the interaction between omeprazole and the metal ions Zn(II), Cu(II), and Co(II).	Omeprazole	42-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-98
11817175-0	2001	In vitro study of the interaction between omeprazole and the metal ions Zn(II), Cu(II), and Co(II).	Metals	61-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-98
11817175-1	2001	The purpose of this study was to investigate the possibility of a chemical interaction between omeprazole (OM) and the metal ions Zn(II), Cu(II), and Co(II).	Omeprazole	95-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	150-156
11817175-1	2001	The purpose of this study was to investigate the possibility of a chemical interaction between omeprazole (OM) and the metal ions Zn(II), Cu(II), and Co(II).	Omeprazole	107-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	150-156
11817175-1	2001	The purpose of this study was to investigate the possibility of a chemical interaction between omeprazole (OM) and the metal ions Zn(II), Cu(II), and Co(II).	Metals	119-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	150-156
11509575-0	2001	Positive and negative regulation of NF-kappaB by COX-2: roles of different prostaglandins.	Prostaglandins	75-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-54
11599950-0	2001	Syntheses, crystal structures, and magnetic properties of one-dimensional oxalato-bridged Co(II), Ni(II), and Cu(II) complexes with n-aminopyridine (n = 2-4) as terminal ligand.	n-aminopyridine	132-147	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-96
11599958-6	2001	In contrast Co(II)(OEB-15,19-(CN)(2)), which was obtained by the insertion of Co(II) into the free ligand, is monomeric with a four-coordinate cobalt ion.	Cobalt	143-149	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-18
11509575-5	2001	Previous reports indicate that the transcription factor NF-kappaB can function upstream of COX-2 to control transcription of this gene and that the cyclopentenone prostaglandins can inhibit NF-kappaB activation via the inhibition of the IkappaB kinase.	cyclopentenone	148-162	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-96
11509575-5	2001	Previous reports indicate that the transcription factor NF-kappaB can function upstream of COX-2 to control transcription of this gene and that the cyclopentenone prostaglandins can inhibit NF-kappaB activation via the inhibition of the IkappaB kinase.	Prostaglandins	163-177	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-96
11483590-8	2001	Preincubation of HUVECs with SQ29548, a TXA2 receptor antagonist, dose-dependently inhibited platelet-induced COX-2 expression and prostanoid synthesis.	SQ 29548	29-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-115
11687965-8	2001	Curiously, treatment of the cells with flurbiprofen enhanced the level of COX-2 expression.	Flurbiprofen	39-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
11687965-10	2001	These observations suggest that the interaction of COX-2 with p53 may cause p21-independent suppression of tumor cell growth upon flurbiprofen treatment.	Flurbiprofen	130-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-56
11600775-2	2001	The O-Co-O bond angle [120.4 (1) degrees] is significantly smaller than the corresponding values previously found for most non-O(2)-bound [Co(II)[(sal)(2)Medpt]]-type molecules (observed range 126.9-138.6 degrees), whereas the equatorial Co-N bond [2.185 (3) A] is relatively long.	o-co-o	4-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-145
11600771-3	2001	A comparison of the O-O [1.483 (3) A], Co-Cl [2.2647 (8) A] and Co-O [1.894 (2) A] bond lengths with similar bonds in previously determined structures indicates the oxidation of Co(II) to Co(III) during the crystallization process.	carboxyl radical	64-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	178-184
11600775-2	2001	The O-Co-O bond angle [120.4 (1) degrees] is significantly smaller than the corresponding values previously found for most non-O(2)-bound [Co(II)[(sal)(2)Medpt]]-type molecules (observed range 126.9-138.6 degrees), whereas the equatorial Co-N bond [2.185 (3) A] is relatively long.	o(2)	127-131	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-145
12024972-2	2001	The enzymes responsible for PG synthesis are cox-1 and cox-2.	pg	28-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-60
11586092-6	2001	Two specific COX-2 inhibitors, namely rofecoxib (Vioxx) and celecoxib (Celebrex), both oral agents and U.S. Food and Drug Administration approved, have been shown preclinically and clinically to have efficacy comparable to that of NSAIDs for relief of pain and inflammation in osteoarthritis, with decreased risk of gastrointestinal damage.	rofecoxib	38-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
11586092-6	2001	Two specific COX-2 inhibitors, namely rofecoxib (Vioxx) and celecoxib (Celebrex), both oral agents and U.S. Food and Drug Administration approved, have been shown preclinically and clinically to have efficacy comparable to that of NSAIDs for relief of pain and inflammation in osteoarthritis, with decreased risk of gastrointestinal damage.	rofecoxib	49-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
11586092-6	2001	Two specific COX-2 inhibitors, namely rofecoxib (Vioxx) and celecoxib (Celebrex), both oral agents and U.S. Food and Drug Administration approved, have been shown preclinically and clinically to have efficacy comparable to that of NSAIDs for relief of pain and inflammation in osteoarthritis, with decreased risk of gastrointestinal damage.	Celecoxib	60-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
11586092-6	2001	Two specific COX-2 inhibitors, namely rofecoxib (Vioxx) and celecoxib (Celebrex), both oral agents and U.S. Food and Drug Administration approved, have been shown preclinically and clinically to have efficacy comparable to that of NSAIDs for relief of pain and inflammation in osteoarthritis, with decreased risk of gastrointestinal damage.	Celecoxib	71-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
11642646-5	2001	Low doses of glucocorticoids (prednisone or prednisolone) accomplish everything NSAIDs or COX-2 inhibitors accomplish but with more antiinflammatory effects, fewer side effects, and much less expense.	Prednisone	30-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-95
11642646-5	2001	Low doses of glucocorticoids (prednisone or prednisolone) accomplish everything NSAIDs or COX-2 inhibitors accomplish but with more antiinflammatory effects, fewer side effects, and much less expense.	Prednisolone	44-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-95
11721898-4	2001	The CL intensity decreased in the order mono- &gt; di- &gt; triethanolamine and Co(II) &gt; Cu(II) &gt; Ni(II) &gt; Fe-(III) &gt; Mn(II) &gt; Fe(II).	Copper	92-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-86
11721898-6	2001	Detection limits (S/N = 3) of H2O2 and glucose using Dowex-50W-X4-Co(II)-monoethanolamine as catalyst are 1 x 10(-7) M and 1 x 10(-6) M, respectively.	Hydrogen Peroxide	30-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-72
11721898-6	2001	Detection limits (S/N = 3) of H2O2 and glucose using Dowex-50W-X4-Co(II)-monoethanolamine as catalyst are 1 x 10(-7) M and 1 x 10(-6) M, respectively.	Glucose	39-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-72
11587608-14	2001	In addition, PPARdelta may be a receptor for COX-2-produced prostaglandins in HNSCCA.	Prostaglandins	60-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-50
11566042-5	2001	Others, such as meloxicam, may inhibit COX-2 by different mechanisms.	Meloxicam	16-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-44
11566042-9	2001	Use of aspirin in the class study has shown that the benefits of COX-2 inhibitors may be reduced by aspirin use.	Aspirin	7-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-70
11566042-9	2001	Use of aspirin in the class study has shown that the benefits of COX-2 inhibitors may be reduced by aspirin use.	Aspirin	100-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-70
11566043-5	2001	The selective COX-2 inhibitor celecoxib has been approved by the FDA for adjuvant treatment of familial adenomatous polyposis, and a large number of prevention and treatment trials of colorectal and other common cancers (prostate and breast cancer) have been started.	Celecoxib	30-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
11592411-1	2001	Selected metal ions having paramagnetic property were found to exert inhibition effects on aquatic photodegradation of organophosphorus pesticides sensitized by humic acids, according to the increasing order of Cr(III) &lt; Co(II) &lt; Mn(II) &lt; Cu(II).	Metals	9-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	224-230
11592411-1	2001	Selected metal ions having paramagnetic property were found to exert inhibition effects on aquatic photodegradation of organophosphorus pesticides sensitized by humic acids, according to the increasing order of Cr(III) &lt; Co(II) &lt; Mn(II) &lt; Cu(II).	organophosphorus	119-135	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	224-230
11592411-1	2001	Selected metal ions having paramagnetic property were found to exert inhibition effects on aquatic photodegradation of organophosphorus pesticides sensitized by humic acids, according to the increasing order of Cr(III) &lt; Co(II) &lt; Mn(II) &lt; Cu(II).	Humic Substances	161-172	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	224-230
11592411-1	2001	Selected metal ions having paramagnetic property were found to exert inhibition effects on aquatic photodegradation of organophosphorus pesticides sensitized by humic acids, according to the increasing order of Cr(III) &lt; Co(II) &lt; Mn(II) &lt; Cu(II).	Chromium	211-213	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	224-230
11581208-8	2001	COX-2 expression in the ciliary body was also lost in patients with steroid-induced glaucoma and was reduced in patients receiving topical steroid treatment.	Steroids	68-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
11581208-8	2001	COX-2 expression in the ciliary body was also lost in patients with steroid-induced glaucoma and was reduced in patients receiving topical steroid treatment.	Steroids	139-146	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
11581208-12	2001	Specific loss of COX-2 expression in the nonpigmented secretory epithelium of the ciliary body appears to be linked to the occurrence of POAG and steroid-induced glaucoma.	Steroids	146-153	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22
11686499-4	2001	Since COII carries a binding site for cytochrome c in the respiratory chain, and since it is required for the passage of chain electrons to molecular oxygen, driving the production of ATP, we hypothesized that metabolic dysfunction resulting from TBI alters COII gene expression directly, perhaps influencing the synaptic plasticity that occurs during postinjury recovery processes.	Oxygen	150-156	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	6-10
11916141-3	2001	An analogous N-phosphonyl-glutamate exhibited significantly greater inhibitory potency than the parent N-thiophosphonyl-glutamate indicating that the sulfur ligand of the N-thiophosphonyl-glutamates is responsible for less favorable active-site interactions than oxygen, potentially due to steric crowding from the longer P-S bond or as a result of active-site metal substitution of Co(II) for Zn(II) arising from assay conditions.	n-phosphonyl-glutamate	13-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	383-389
11916141-3	2001	An analogous N-phosphonyl-glutamate exhibited significantly greater inhibitory potency than the parent N-thiophosphonyl-glutamate indicating that the sulfur ligand of the N-thiophosphonyl-glutamates is responsible for less favorable active-site interactions than oxygen, potentially due to steric crowding from the longer P-S bond or as a result of active-site metal substitution of Co(II) for Zn(II) arising from assay conditions.	n-thiophosphonyl-glutamate	103-129	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	383-389
11916141-3	2001	An analogous N-phosphonyl-glutamate exhibited significantly greater inhibitory potency than the parent N-thiophosphonyl-glutamate indicating that the sulfur ligand of the N-thiophosphonyl-glutamates is responsible for less favorable active-site interactions than oxygen, potentially due to steric crowding from the longer P-S bond or as a result of active-site metal substitution of Co(II) for Zn(II) arising from assay conditions.	Sulfur	150-156	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	383-389
11916141-3	2001	An analogous N-phosphonyl-glutamate exhibited significantly greater inhibitory potency than the parent N-thiophosphonyl-glutamate indicating that the sulfur ligand of the N-thiophosphonyl-glutamates is responsible for less favorable active-site interactions than oxygen, potentially due to steric crowding from the longer P-S bond or as a result of active-site metal substitution of Co(II) for Zn(II) arising from assay conditions.	n-thiophosphonyl-glutamates	171-198	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	383-389
11686499-4	2001	Since COII carries a binding site for cytochrome c in the respiratory chain, and since it is required for the passage of chain electrons to molecular oxygen, driving the production of ATP, we hypothesized that metabolic dysfunction resulting from TBI alters COII gene expression directly, perhaps influencing the synaptic plasticity that occurs during postinjury recovery processes.	Adenosine Triphosphate	184-187	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	6-10
11576568-1	2001	OBJECTIVE: To compare the effects of three cyclooxygenase-2 (COX-2) inhibitors: nimesulide, meloxicam, and celecoxib, which exhibit varying COX-2 selectivity, on contractile activity in pregnant (before and after labor) and nonpregnant human myometrial tissue in vitro.	Celecoxib	107-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-145
11695069-0	2001	Double-blind study comparing the long-term efficacy of the COX-2 inhibitor nimesulide and naproxen in patients with osteoarthritis.	nimesulide	75-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-64
11576568-9	2001	Celecoxib, a COX-2 specific inhibitor, was more potent than nimesulide or meloxicam, COX-2 preferential inhibitors.	Celecoxib	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
11525666-2	2001	The hyperfine-shifted (1)H NMR signals of the Co(II) complexes of several 2,6-diamidopyridine-containing dendrimers have been fully assigned by means of 1D and 2D NMR techniques, including NOE difference, EXSY, COSY, and TOCSY.	2,6-diamidopyridine	74-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-52
11418589-1	2001	We have recently shown that two distinct prostaglandin (PG) E(2) synthases show preferential functional coupling with upstream cyclooxygenase (COX)-1 and COX-2 in PGE(2) biosynthesis.	Dinoprostone	163-169	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	154-159
11418589-3	2001	As did the membrane-bound PGE(2) synthase, the perinuclear enzymes thromboxane synthase and PGI(2) synthase generated their respective products via COX-2 in preference to COX-1 in both the -induced immediate and interleukin-1-induced delayed responses.	Prostaglandins E	26-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	148-153
11418589-4	2001	Hematopoietic PGD(2) synthase preferentially used COX-1 and COX-2 in the -induced immediate and interleukin-1-induced delayed PGD(2)-biosynthetic responses, respectively.	Prostaglandin D2	14-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-65
11418589-4	2001	Hematopoietic PGD(2) synthase preferentially used COX-1 and COX-2 in the -induced immediate and interleukin-1-induced delayed PGD(2)-biosynthetic responses, respectively.	Prostaglandin D2	14-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-65
11601668-2	2001	Cyclooxygenase (COX)-2 inhibitors (coxibs) rofecoxib and celecoxib are highly selective inhibitors of COX-2, differentiating them from nonselective NSAIDs, which substantially inhibit both COX-1 and COX-2.	rofecoxib	43-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-107
11601668-2	2001	Cyclooxygenase (COX)-2 inhibitors (coxibs) rofecoxib and celecoxib are highly selective inhibitors of COX-2, differentiating them from nonselective NSAIDs, which substantially inhibit both COX-1 and COX-2.	rofecoxib	43-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	199-204
11601668-2	2001	Cyclooxygenase (COX)-2 inhibitors (coxibs) rofecoxib and celecoxib are highly selective inhibitors of COX-2, differentiating them from nonselective NSAIDs, which substantially inhibit both COX-1 and COX-2.	Celecoxib	57-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-107
11601668-2	2001	Cyclooxygenase (COX)-2 inhibitors (coxibs) rofecoxib and celecoxib are highly selective inhibitors of COX-2, differentiating them from nonselective NSAIDs, which substantially inhibit both COX-1 and COX-2.	Celecoxib	57-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	199-204
11572998-9	2001	Avicin G treatment resulted in decreased expression of NF-kappaB-regulated proteins such as inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX-2).	avicin G	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-156
11592385-10	2001	Triptolide also inhibited the IL-1alpha-induced production of PGE2 by selectively suppressing the gene expression and production of COX-2, but not those of COX-1.	triptolide	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-137
12240429-1	2001	The trans/cis ratio of the azobenzene-attached bipyridine ligands in a cobalt complex is reversibly altered by a combination of photoirradiation with a single UV light source and the reversible redox change between Co(II) and Co(III).	2,2'-Dipyridyl	47-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	215-221
12240429-1	2001	The trans/cis ratio of the azobenzene-attached bipyridine ligands in a cobalt complex is reversibly altered by a combination of photoirradiation with a single UV light source and the reversible redox change between Co(II) and Co(III).	Cobalt	71-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	215-221
11570615-6	2001	Reaction rates for COX-2 inhibitors were 21.3% for nimesulide, 17.3% for meloxicam, 33.3% for celecoxib, and 3.0% for rofecoxib.	nimesulide	51-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-24
11570615-6	2001	Reaction rates for COX-2 inhibitors were 21.3% for nimesulide, 17.3% for meloxicam, 33.3% for celecoxib, and 3.0% for rofecoxib.	Meloxicam	73-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-24
11570615-6	2001	Reaction rates for COX-2 inhibitors were 21.3% for nimesulide, 17.3% for meloxicam, 33.3% for celecoxib, and 3.0% for rofecoxib.	Celecoxib	94-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-24
11570615-6	2001	Reaction rates for COX-2 inhibitors were 21.3% for nimesulide, 17.3% for meloxicam, 33.3% for celecoxib, and 3.0% for rofecoxib.	rofecoxib	118-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-24
11570615-7	2001	CONCLUSIONS: Some COX-2 inhibitors, such as rofecoxib, are relatively safe in NSAID-sensitive patients with urticaria or angioedema.	rofecoxib	44-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-23
12240429-0	2001	Reversible trans-cis photoisomerization of azobenzene-attached bipyridine ligands coordinated to cobalt using a single UV light source and the Co(III)/Co(II) redox change.	azobenzene	43-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	143-148
12240429-0	2001	Reversible trans-cis photoisomerization of azobenzene-attached bipyridine ligands coordinated to cobalt using a single UV light source and the Co(III)/Co(II) redox change.	2,2'-Dipyridyl	63-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	143-148
12240429-0	2001	Reversible trans-cis photoisomerization of azobenzene-attached bipyridine ligands coordinated to cobalt using a single UV light source and the Co(III)/Co(II) redox change.	Cobalt	97-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	143-148
12240429-1	2001	The trans/cis ratio of the azobenzene-attached bipyridine ligands in a cobalt complex is reversibly altered by a combination of photoirradiation with a single UV light source and the reversible redox change between Co(II) and Co(III).	azobenzene	27-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	215-221
11592385-10	2001	Triptolide also inhibited the IL-1alpha-induced production of PGE2 by selectively suppressing the gene expression and production of COX-2, but not those of COX-1.	Dinoprostone	62-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-137
11545522-1	2001	The enhanced generation of singlet oxygen (1O2) during oxidation of farmorubicin in the Co(II) + H2O2 system was studied using chemiluminescent, fluorescent and spectrophotometic techniques.	Singlet Oxygen	27-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-94
11532880-2	2001	Activity of one of the COX isoforms, COX-2, results in production of prostaglandin E(2) (PGE(2)) via the endoperoxide PGH(2).	Dinoprostone	69-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-42
11532880-2	2001	Activity of one of the COX isoforms, COX-2, results in production of prostaglandin E(2) (PGE(2)) via the endoperoxide PGH(2).	Prostaglandins E	89-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-42
11532880-2	2001	Activity of one of the COX isoforms, COX-2, results in production of prostaglandin E(2) (PGE(2)) via the endoperoxide PGH(2).	GH2 protein, human	118-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-42
11532880-10	2001	Induction of COX-2 expression by phorbol 12-myristate 13-acetate in HCEC cells increased PGE(2) production 20-fold and MDA concentration 3-fold.	Tetradecanoylphorbol Acetate	33-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
11532880-10	2001	Induction of COX-2 expression by phorbol 12-myristate 13-acetate in HCEC cells increased PGE(2) production 20-fold and MDA concentration 3-fold.	Dinoprostone	89-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
11532880-11	2001	Selective inhibition of COX-2 activity in HCA-7 cells by NS-398 significantly inhibited PGE(2) production, but altered neither MDA nor M(1)G levels.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	57-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
11532880-11	2001	Selective inhibition of COX-2 activity in HCA-7 cells by NS-398 significantly inhibited PGE(2) production, but altered neither MDA nor M(1)G levels.	Prostaglandins E	88-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
11545522-1	2001	The enhanced generation of singlet oxygen (1O2) during oxidation of farmorubicin in the Co(II) + H2O2 system was studied using chemiluminescent, fluorescent and spectrophotometic techniques.	1o2)	43-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-94
11545522-1	2001	The enhanced generation of singlet oxygen (1O2) during oxidation of farmorubicin in the Co(II) + H2O2 system was studied using chemiluminescent, fluorescent and spectrophotometic techniques.	Epirubicin	68-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-94
11589261-4	2001	OBJECTIVE: This study sought to compare renal safety signals between the COX-2-specific inhibitors rofecoxib and celecoxib, based on spontaneous reports of adverse drug reactions (ADRs) in the World Health Organization/Uppsala Monitoring Centre (WHO/UMC) safety database through the end of the second quarter 2000.	rofecoxib	99-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-78
11545522-1	2001	The enhanced generation of singlet oxygen (1O2) during oxidation of farmorubicin in the Co(II) + H2O2 system was studied using chemiluminescent, fluorescent and spectrophotometic techniques.	Hydrogen Peroxide	97-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-94
11672885-0	2001	Synthesis and receptor docking studies of N-substituted indole-2-carboxylic acid esters as a search for COX-2 selective enzyme inhibitors.	n-substituted indole-2-carboxylic acid esters	42-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
11785654-1	2001	Experiments were conducted to determine the effects of novel anti-neoplastic isochalcones (DJ compounds), on cyclooxyegenase 1 and 2 (COX-1 and COX-2) enzyme expression in androgen receptor dependent human prostate cancer cell line LNCaP.	isochalcones	77-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	144-149
11785654-4	2001	In this study, we report that novel isochalcones decreased COX-1, COX-2 and EGF levels as well as LNCaP cellular growth in a dose responsive manner.	isochalcones	36-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-71
11672885-4	2001	All the compounds were shown to be docked at the site where intact flurbiprofen was embedded for COX-1 and s-58 (1-phenylsulphonamide-3-trifluoromethyl-5-para-bromophenylpyrazole) for COX-2.	Flurbiprofen	67-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	184-189
11672885-4	2001	All the compounds were shown to be docked at the site where intact flurbiprofen was embedded for COX-1 and s-58 (1-phenylsulphonamide-3-trifluoromethyl-5-para-bromophenylpyrazole) for COX-2.	1-phenylsulphonamide-3-trifluoromethyl-5-para-bromophenylpyrazole	113-178	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	184-189
11672885-5	2001	It was predicted that N-phenyl-indole-2-carboxylic acid piperazine ester 22 can be a fairly strong COX-2 selective compound which was compared to the others.	n-phenyl-indole-2-carboxylic acid piperazine ester	22-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-104
11511570-1	2001	Cyclooxygenase (COX), the key enzyme for synthesis of prostaglandins, exists in two isoforms (COX-1 and COX-2).	Prostaglandins	54-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
11672885-6	2001	Other predicted COX-2 selective compounds included are N--H indole-2-carboxylic acid diethyl 30 and piperazine 34 esters.	n--h indole-2-carboxylic acid diethyl 30	55-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-21
11672885-6	2001	Other predicted COX-2 selective compounds included are N--H indole-2-carboxylic acid diethyl 30 and piperazine 34 esters.	Piperazine	100-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-21
11672885-6	2001	Other predicted COX-2 selective compounds included are N--H indole-2-carboxylic acid diethyl 30 and piperazine 34 esters.	Esters	114-120	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-21
11527948-10	2001	There was a direct relationship between both the appearance and amount of COX-2 mRNA and protein synthesis and the degree of PG synthesis by RPE cells.	Prostaglandins	125-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
15100894-0	2001	Integration of a wet analysis system on a glass chip: determination of Co(ii) as 2-nitroso-1-naphthol chelates by solvent extraction and thermal lens microscopy.	2-nitroso-1-naphthol	81-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-77
11509550-7	2001	Treatment with the selective COX-2 inhibitor NS-398 abolished the synergistic effects of TNF-alpha and IL-1 beta on beta-adrenergic responsiveness.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	45-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34
11509629-0	2001	Roles of cyclooxygenase (COX)-1 and COX-2 in prostanoid production by human endothelial cells: selective up-regulation of prostacyclin synthesis by COX-2.	Epoprostenol	122-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	148-153
11509629-1	2001	The two cyclooxygenase (COX) isoforms, COX-1 and COX-2, both metabolize arachidonic acid to PGH(2), the common substrate for thromboxane A(2) (TXA(2)), prostacyclin (PGI(2)), and PGE(2) synthesis.	Arachidonic Acid	72-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-54
11509629-1	2001	The two cyclooxygenase (COX) isoforms, COX-1 and COX-2, both metabolize arachidonic acid to PGH(2), the common substrate for thromboxane A(2) (TXA(2)), prostacyclin (PGI(2)), and PGE(2) synthesis.	GH2 protein, human	92-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-54
11509629-1	2001	The two cyclooxygenase (COX) isoforms, COX-1 and COX-2, both metabolize arachidonic acid to PGH(2), the common substrate for thromboxane A(2) (TXA(2)), prostacyclin (PGI(2)), and PGE(2) synthesis.	thromboxane a	125-138	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-54
11509629-1	2001	The two cyclooxygenase (COX) isoforms, COX-1 and COX-2, both metabolize arachidonic acid to PGH(2), the common substrate for thromboxane A(2) (TXA(2)), prostacyclin (PGI(2)), and PGE(2) synthesis.	Epoprostenol	152-164	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-54
11509629-1	2001	The two cyclooxygenase (COX) isoforms, COX-1 and COX-2, both metabolize arachidonic acid to PGH(2), the common substrate for thromboxane A(2) (TXA(2)), prostacyclin (PGI(2)), and PGE(2) synthesis.	Prostaglandins I	166-169	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-54
11509629-1	2001	The two cyclooxygenase (COX) isoforms, COX-1 and COX-2, both metabolize arachidonic acid to PGH(2), the common substrate for thromboxane A(2) (TXA(2)), prostacyclin (PGI(2)), and PGE(2) synthesis.	Prostaglandins E	179-182	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-54
11509629-2	2001	We characterized the synthesis of these prostanoids in HUVECs in relation to COX-1 and COX-2 activity.	Prostaglandins	40-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-92
11509629-5	2001	By contrast, COX-2 up-regulation was associated with large increases in the synthesis of PGI(2) and PGE(2) (54- and 84-fold increases, respectively).	Prostaglandins I	89-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
11509629-5	2001	By contrast, COX-2 up-regulation was associated with large increases in the synthesis of PGI(2) and PGE(2) (54- and 84-fold increases, respectively).	Prostaglandins E	100-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
11509629-6	2001	Addition of the selective COX-2 inhibitor, NS-398, almost completely abolished PGI(2) and PGE(2) synthesis, but had little effect on TXA(2) synthesis.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	43-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-31
11509629-6	2001	Addition of the selective COX-2 inhibitor, NS-398, almost completely abolished PGI(2) and PGE(2) synthesis, but had little effect on TXA(2) synthesis.	Prostaglandins I	79-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-31
11509629-6	2001	Addition of the selective COX-2 inhibitor, NS-398, almost completely abolished PGI(2) and PGE(2) synthesis, but had little effect on TXA(2) synthesis.	Prostaglandins E	90-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-31
11509629-9	2001	In conclusion, endothelial prostanoid synthesis appears to be differentially regulated by the induction of COX-2.	Prostaglandins	27-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-112
11509629-10	2001	The apparent PGI(2) and PGE(2) linkage with COX-2 activity may be explained by a temporal increase in total COX activity, together with selective up-regulation of PGI synthase and PGE synthase, and different kinetic characteristics of the terminal synthases.	Prostaglandins I	13-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-49
11509629-10	2001	The apparent PGI(2) and PGE(2) linkage with COX-2 activity may be explained by a temporal increase in total COX activity, together with selective up-regulation of PGI synthase and PGE synthase, and different kinetic characteristics of the terminal synthases.	Prostaglandins E	24-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-49
15100894-2	2001	The Co(II) was extracted into m-xylene from aqueous solution as 2-nitroso-1-naphthol chelates, and colorimetric determination of the m-xylene phase was applied by a thermal lens microscope.	3-xylene	30-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
15100894-2	2001	The Co(II) was extracted into m-xylene from aqueous solution as 2-nitroso-1-naphthol chelates, and colorimetric determination of the m-xylene phase was applied by a thermal lens microscope.	2-nitroso-1-naphthol	64-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
15100894-2	2001	The Co(II) was extracted into m-xylene from aqueous solution as 2-nitroso-1-naphthol chelates, and colorimetric determination of the m-xylene phase was applied by a thermal lens microscope.	3-xylene	133-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
11506482-3	2001	This environment includes upregulation of mediators of the inflammatory response such as cyclo-oxygenase (COX)-2 leading to the production of inflammatory cytokines and prostaglandins which themselves may suppress cell mediated immune responses and promote angiogenesis.	Prostaglandins	169-183	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-112
11511198-4	2001	Both compounds exhibit cationic tetramers consisting of a dicubane-like core with two missing vertexes where the Co(II) ions are connected through end-on pseudohalide and oxo-bridges.	pseudohalide	154-166	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-119
11511198-7	2001	The tetrameric units for 2 and 3 represent the first examples of any kind of cubanes exhibiting cyanate bridges as well as the first Co(II) compounds exhibiting intermetallic bridges through these pseudohalide groups.	pseudohalide	197-209	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	133-139
11526505-3	2001	Analyses with the COX-2 promoter region revealed that the cyclic AMP responsive element near the TATA box was essential for both basal and UVB induced COX-2 expression.	Cyclic AMP	58-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-23
11526505-3	2001	Analyses with the COX-2 promoter region revealed that the cyclic AMP responsive element near the TATA box was essential for both basal and UVB induced COX-2 expression.	Cyclic AMP	58-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-156
11526505-6	2001	CREB and ATF-1 were phosphorylated upon UVB treatment, and SB202190, a p38 MAPK inhibitor, decreased the phosphorylation of CREB/ATF-1 and suppressed COX-2 promoter activity.	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	59-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	150-155
11526505-7	2001	In contrast, treatment with forskolin, an activator of adenylyl cyclase, led to phosphorylation of CREB and ATF-1 and activation of COX-2 promoter.	Colforsin	28-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-137
11577463-0	2001	[Cyclooxygenase (COX)-2 selective inhibitors: aspirin, a dual COX-1/COX-2 inhibitor, to COX-2 selective inhibitors].	Aspirin	46-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-73
11577463-2	2001	During the century after that, aspirin has been found to show its anti-inflammatory, analgesic and anti-pyretic activities by reducing prostaglandins biosynthesis through inhibition of cyclooxygenase (COX); and then COX was found to be constituted of two isoforms, constitutive COX-1 and inducible COX-2.	Aspirin	31-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	298-303
11577463-3	2001	Currently, novel NSAIDs, acting through selective inhibition of COX-2, that have efficacy as excellent as aspirin with significantly lower incidence of gastrointestinal adverse effects are available in America and some other countries, but not in Japan.	Aspirin	106-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-69
11571832-7	2001	COX-2, in contrast, is highly regulated, the prostaglandins produced by this isoenzyme are involved in inflammation, fever and pain but also in the regulation of kidney function.	Prostaglandins	45-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
11571832-10	2001	In search for selective blockers of COX-2, celecoxib and rofecoxib were developed which have an analgetic and antirheumatic potency similar to that of conventional NSAIDs but are associated with significantly fewer adverse gastroduodenal events.	rofecoxib	57-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-41
11487528-2	2001	Incubation of human umbilical vein endothelial cells (HUVEC) with SIN-1 (3-morpholinosydnonimine), a donor of NO, resulted in a rapid and dose-dependent increase in the expression of COX-2 as analysed by Western and Northern blotting.	linsidomine	73-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	183-188
11487315-3	2001	In the mixed diporphyrin systems, a strong pipi fluorescence is detected from the free base, while the transition metalloporphyrins of Co(II) and Ru(II) do not emit.	Metalloporphyrins	114-131	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-152
18968358-6	2001	As for Cu(II), the interference by Co(II) was very serious, which was eliminated by oxalate ion.	cu(ii)	7-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-41
18968358-6	2001	As for Cu(II), the interference by Co(II) was very serious, which was eliminated by oxalate ion.	Oxalates	84-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-41
11487528-4	2001	The COX-2 induction was dependent on a de novo synthesis since cycloheximide, an inhibitor of protein synthesis, blocked the enzyme expression.	Cycloheximide	63-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
11487528-6	2001	However, the COX activity was partially recovered when immunoprecipitated COX-2 was incubated with arachidonic acid and haematin.	Arachidonic Acid	99-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
11487528-6	2001	However, the COX activity was partially recovered when immunoprecipitated COX-2 was incubated with arachidonic acid and haematin.	Hemin	120-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
11487528-7	2001	Peroxynitrite, a highly reactive nitrogen molecule derived from the interaction of NO and superoxide anion, significantly increased COX-2 expression.	Peroxynitrous Acid	0-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-137
11487528-7	2001	Peroxynitrite, a highly reactive nitrogen molecule derived from the interaction of NO and superoxide anion, significantly increased COX-2 expression.	Nitrogen	33-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-137
11487528-7	2001	Peroxynitrite, a highly reactive nitrogen molecule derived from the interaction of NO and superoxide anion, significantly increased COX-2 expression.	Superoxides	90-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-137
11487528-9	2001	Ro 31-8220, a specific inhibitor of protein kinase (PK) C, blocked the induction of COX-2.	Ro 31-8220	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-89
11487528-10	2001	Also, SB203580, the selective inhibitor of p38 MAP kinase, strongly blocked the induction of COX-2 by SIN-1 in the presence or absence of IL-1alpha, whereas the MEK-1 inhibitor, PD 98059, affected it to a lesser extent.	SB 203580	6-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-98
11442372-4	2001	[Cu2(H2R)](ClO4)2 was converted by neutralization into [Cu2(R)], from which mixed-metal Cu(II)2M(II)2 complexes [Cu2M2(R)Cl4] (M = Co(II), Ni(II), Zn(II)) were derived.	cu2(h2r)](clo4)2	1-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-137
15973593-1	2001	Pharmacia corp. Pharmacia (formerly Monsanto) is developing parecoxib, an injectable COX-2 inhibitor, for the management of post-surgical acute pain [287279], [313957].	parecoxib	60-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-90
11556519-13	2001	In the whole blood test, aceclofenac and 4"-hydroxyaceclofenac weakly inhibited COX-1 with IC50 values superior to 100 microM, but decreased by 50% COX-2 activity at the concentration of 0.77 and 36 microM, respectively.	aceclofenac	25-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	148-153
11556519-13	2001	In the whole blood test, aceclofenac and 4"-hydroxyaceclofenac weakly inhibited COX-1 with IC50 values superior to 100 microM, but decreased by 50% COX-2 activity at the concentration of 0.77 and 36 microM, respectively.	4'-hydroxyaceclofenac	41-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	148-153
11556519-14	2001	Diclofenac strongly inhibited both COX-1 and COX-2 with IC50 values of 0.6 and 0.04 microM, respectively.	Diclofenac	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-50
11495083-1	2001	BACKGROUND: The cyclooxygenase (COX) enzymes exist in two related but unique isoforms (COX-1 and COX-2) and catalyze the formation of prostaglandins (PGs).	Prostaglandins	134-148	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
11495083-1	2001	BACKGROUND: The cyclooxygenase (COX) enzymes exist in two related but unique isoforms (COX-1 and COX-2) and catalyze the formation of prostaglandins (PGs).	Prostaglandins	150-153	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
11534854-7	2001	In other rings, indomethacin (30, 100 micromol/l) or NS-398 (10, 30 micromol/l) produced a significant rightward shift of the CRC to BK, selective BK B2 agonist, and its pKbs were similar to the values to inhibit BK B1 receptor responses, suggesting that COX-2 pathway also is involved in BK B2 receptor responses.	Indomethacin	16-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	255-260
11534854-7	2001	In other rings, indomethacin (30, 100 micromol/l) or NS-398 (10, 30 micromol/l) produced a significant rightward shift of the CRC to BK, selective BK B2 agonist, and its pKbs were similar to the values to inhibit BK B1 receptor responses, suggesting that COX-2 pathway also is involved in BK B2 receptor responses.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	53-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	255-260
11442372-4	2001	[Cu2(H2R)](ClO4)2 was converted by neutralization into [Cu2(R)], from which mixed-metal Cu(II)2M(II)2 complexes [Cu2M2(R)Cl4] (M = Co(II), Ni(II), Zn(II)) were derived.	cu2(r)	56-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-137
11442372-4	2001	[Cu2(H2R)](ClO4)2 was converted by neutralization into [Cu2(R)], from which mixed-metal Cu(II)2M(II)2 complexes [Cu2M2(R)Cl4] (M = Co(II), Ni(II), Zn(II)) were derived.	cu(ii)2m(ii)2	88-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-137
29712296-1	2001	Four tetramers of MoV centers and four tetramers of CoII centers, linked by phosphate groups around a central isolated [Co(H2 O)6 ]2+ octahedron form the key structural unit in the molybdenum(V) cobaltophosphates 1 and 2, which were prepared by hydrothermal synthesis.	Phosphates	76-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-56
11410869-7	2001	The percentage of apoptosis induced by NS398 was associated with the level of COX-2 expression.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	39-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-83
11469677-2	2001	Since NSAIDs are known to inhibit cyclooxygenases (COX-1, COX-2), the basic mechanism of their antitumor effects is conceivably the altered metabolism of arachidonic acid and, subsequently, prostaglandins (PGs).	Arachidonic Acid	154-170	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
29712296-1	2001	Four tetramers of MoV centers and four tetramers of CoII centers, linked by phosphate groups around a central isolated [Co(H2 O)6 ]2+ octahedron form the key structural unit in the molybdenum(V) cobaltophosphates 1 and 2, which were prepared by hydrothermal synthesis.	cobaltophosphates	195-212	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-56
11443200-3	2001	The IL-1alpha-induced PTHrP production was inhibited by PG H synthetase (Cox) inhibitors, indomethacin, and also by Cox-2 inhibitor, NS398.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	133-138	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-121
11401839-5	2001	The continuous rise in prostanoid synthesis at 17-23 h of stimulation was associated with COX-2 relocation from the nucleus to the nuclear envelope and the cytoplasm.	Prostaglandins	23-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-95
11425807-0	2001	Induction of delayed follicular rupture in the human by the selective COX-2 inhibitor rofecoxib: a randomized double-blind study.	rofecoxib	86-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-75
11425807-2	2001	METHODS: Thirteen healthy women, 30-40 years of age, without hormonal treatment and with regular menstrual cycles (27-34 days), were given the selective COX-2 inhibitor rofecoxib (n = 6) or placebo (n = 7) in a random double-blind fashion.	rofecoxib	169-178	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	153-158
11469677-2	2001	Since NSAIDs are known to inhibit cyclooxygenases (COX-1, COX-2), the basic mechanism of their antitumor effects is conceivably the altered metabolism of arachidonic acid and, subsequently, prostaglandins (PGs).	Prostaglandins	190-204	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
11469677-4	2001	In addition, hypoxic conditions and sodium butyrate exposure may also contribute to COX-2 gene transcription in human cancers.	Butyric Acid	36-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-89
11408553-7	2001	We also demonstrated that PC-ibuprofen was a comparable or a more effective inhibitor of both 6-keto-prostaglandin F1alpha concentration of fluid collected from tissue in and around the inflamed stifle joint, and COX-2 activity in activated human umbilical vein endothelial cells.	pc-ibuprofen	26-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	213-218
11433185-8	2001	These protective and hyperemic effects of standard preconditioning, lasted up to 6-8 h, and were significantly attenuated by pretreatment with specific COX-1 and COX-2 inhibitors such as Vioxx (5 mg/kg i.g.)	rofecoxib	187-192	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	162-167
11469463-6	2001	RESULTS: Constitutive PGE2 production was significantly upregulated and IL-1beta induced PGE2 production was increased by the enhancing expression of both COX-2 mRNA and protein in fibroblasts from scleroderma involved skin; PGE2 production and COX-2 expression were inhibited by UVA irradiation.	Dinoprostone	89-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	155-160
11469463-6	2001	RESULTS: Constitutive PGE2 production was significantly upregulated and IL-1beta induced PGE2 production was increased by the enhancing expression of both COX-2 mRNA and protein in fibroblasts from scleroderma involved skin; PGE2 production and COX-2 expression were inhibited by UVA irradiation.	Dinoprostone	89-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	245-250
11469463-6	2001	RESULTS: Constitutive PGE2 production was significantly upregulated and IL-1beta induced PGE2 production was increased by the enhancing expression of both COX-2 mRNA and protein in fibroblasts from scleroderma involved skin; PGE2 production and COX-2 expression were inhibited by UVA irradiation.	Dinoprostone	89-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	155-160
11469463-6	2001	RESULTS: Constitutive PGE2 production was significantly upregulated and IL-1beta induced PGE2 production was increased by the enhancing expression of both COX-2 mRNA and protein in fibroblasts from scleroderma involved skin; PGE2 production and COX-2 expression were inhibited by UVA irradiation.	Dinoprostone	89-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	245-250
11469463-7	2001	CONCLUSION: Enhanced PGE2 production regulated by COX-2 expression in scleroderma fibroblasts may contribute to the development of this disorder.	Dinoprostone	21-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-55
11469463-8	2001	PUVA therapy might exhibit its beneficial effect, at least in part, by inhibiting COX-2 expression transcriptionally and translationally, with subsequent inhibition of PGE2 production.	puva	0-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
11466573-4	2001	The early immediate response genes iNOS and COX-2 promote the inflammatory response by the rapid and excessive production of nitric oxide (NO) and prostaglandins.	Nitric Oxide	125-137	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-49
11466573-4	2001	The early immediate response genes iNOS and COX-2 promote the inflammatory response by the rapid and excessive production of nitric oxide (NO) and prostaglandins.	Prostaglandins	147-161	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-49
11433218-1	2001	Ibuprofen is a cyclooxygenase (COX-1 and COX-2) inhibitor known to reduce the production of prostaglandins that play prominent role in inflammation.	Ibuprofen	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-46
11433218-1	2001	Ibuprofen is a cyclooxygenase (COX-1 and COX-2) inhibitor known to reduce the production of prostaglandins that play prominent role in inflammation.	Prostaglandins	92-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-46
11275357-2	2001	Expression of cyclooxygenase(COX)-1 and COX-2 in the spinal cord and primary afferents suggests that NSAIDs act here by inhibiting the synthesis of prostaglandins (PGs).	Prostaglandins	148-162	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
11275357-2	2001	Expression of cyclooxygenase(COX)-1 and COX-2 in the spinal cord and primary afferents suggests that NSAIDs act here by inhibiting the synthesis of prostaglandins (PGs).	Prostaglandins	164-167	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
11275357-11	2001	Direct administration of PGs to the spinal cord causes hyperalgesia and allodynia, and some studies have shown an association between induction of COX-2, increased PG release and enhanced nociception.	Prostaglandins	25-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-152
11275357-11	2001	Direct administration of PGs to the spinal cord causes hyperalgesia and allodynia, and some studies have shown an association between induction of COX-2, increased PG release and enhanced nociception.	Prostaglandins	25-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-152
11488453-2	2001	Dichloromethane (DCM) extracts from dried leaves showed a marked cyclooxygenase (COX) inhibitory activity with a preferential effect on COX-2 catalysed prostaglandin synthesis.	Methylene Chloride	0-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	136-141
11488453-2	2001	Dichloromethane (DCM) extracts from dried leaves showed a marked cyclooxygenase (COX) inhibitory activity with a preferential effect on COX-2 catalysed prostaglandin synthesis.	Methylene Chloride	17-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	136-141
11488453-2	2001	Dichloromethane (DCM) extracts from dried leaves showed a marked cyclooxygenase (COX) inhibitory activity with a preferential effect on COX-2 catalysed prostaglandin synthesis.	Prostaglandins	152-165	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	136-141
11471717-1	2001	Studies on dicluxacillin complexes of FeII, FeIII, CoII NiII and CuII.	dicluxacillin	11-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-55
11488453-4	2001	High-resolution activity directed on-line identification of the COX-2 inhibitory principle, using a combination of LC-DAD-MS with a microtitre-based bioassay, led to the identification of tryptanthrin (1) as the constituent responsible for essentially all COX-2 inhibitory activity in the crude extract.	tryptanthrine	188-200	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-69
11488453-4	2001	High-resolution activity directed on-line identification of the COX-2 inhibitory principle, using a combination of LC-DAD-MS with a microtitre-based bioassay, led to the identification of tryptanthrin (1) as the constituent responsible for essentially all COX-2 inhibitory activity in the crude extract.	tryptanthrine	188-200	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	256-261
11471717-6	2001	yH2O where DC is the uninegatively charged bidentate ligand and A = OAc in case of CuII and Cl in case of FeIII, FeII, CoII and NiII ions.	yh2o	0-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-123
11471717-6	2001	yH2O where DC is the uninegatively charged bidentate ligand and A = OAc in case of CuII and Cl in case of FeIII, FeII, CoII and NiII ions.	SDZ 33-243	68-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-123
11414818-0	2001	Bicarbonate as a proton donor in catalysis by Zn(II)- and Co(II)-containing carbonic anhydrases.	Bicarbonates	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
11414818-1	2001	Catalysis of (18)O exchange between CO(2) and water catalyzed by a Co(II)-substituted mutant of human carbonic anhydrase II is analyzed to show the rate of release of H(2)(18)O from the active site.	co(2)	36-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-72
11414818-1	2001	Catalysis of (18)O exchange between CO(2) and water catalyzed by a Co(II)-substituted mutant of human carbonic anhydrase II is analyzed to show the rate of release of H(2)(18)O from the active site.	Water	46-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-72
11414818-1	2001	Catalysis of (18)O exchange between CO(2) and water catalyzed by a Co(II)-substituted mutant of human carbonic anhydrase II is analyzed to show the rate of release of H(2)(18)O from the active site.	Hydrogen	167-172	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-72
11439356-6	2001	We found that SB202190 strongly inhibited UVB induced COX-2 protein expression at different time points and various UVB doses.	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	14-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-59
11414818-3	2001	Upon increasing the concentration of bicarbonate, the rate of release of H(2)(18)O increased in a saturable manner to a maximum of 4 x 10(5) s(-)(1), consistent with proton transfer from bicarbonate to the Co(II)-bound hydroxide.	Bicarbonates	37-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	206-211
11414818-3	2001	Upon increasing the concentration of bicarbonate, the rate of release of H(2)(18)O increased in a saturable manner to a maximum of 4 x 10(5) s(-)(1), consistent with proton transfer from bicarbonate to the Co(II)-bound hydroxide.	Bicarbonates	187-198	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	206-211
11414818-3	2001	Upon increasing the concentration of bicarbonate, the rate of release of H(2)(18)O increased in a saturable manner to a maximum of 4 x 10(5) s(-)(1), consistent with proton transfer from bicarbonate to the Co(II)-bound hydroxide.	hydroxide ion	219-228	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	206-211
11414818-4	2001	The same mutant of carbonic anhydrase containing Zn(II) had the rate of release of H(2)(18)O smaller by 10-fold, but rate of interconversion of CO(2) and HCO(3)(-) about the same as the Co(II)-containing enzyme.	Zinc	49-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	186-191
11412976-1	2001	Computational studies have yielded an analysis of the contributions to the free energy difference between the binding of celecoxib to COX-1 and to COX-2.	Celecoxib	121-130	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-152
11412976-0	2001	Rationale for the observed COX-2/COX-1 selectivity of celecoxib from Monte Carlo simulations.	Celecoxib	54-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-32
11465459-5	2001	An X-ray structure of (1:1)-cocrystals of an achiral, biconcave CoII porphyrinate and C60 provided the first detailed insights into the structure of such a biconcave metallo-porphyrinate.	metallo-porphyrinate	166-186	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-68
11320076-4	2001	COX-2-S clones expressed significantly more COX-2 protein, produced 10-fold more prostaglandin E(2), and demonstrated an enhanced invasive capacity compared with control vector-transduced or parental cells.	Dinoprostone	81-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
11320076-5	2001	CD44, the cell surface receptor for hyaluronate, was overexpressed in COX-2-S cells, and specific blockade of CD44 significantly decreased tumor cell invasion.	hyaluronate	36-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-75
11278846-2	2001	This study demonstrates that sodium salicylate at a therapeutic concentration suppressed COX-2 gene transcription induced by phorbol 12-myristate 13-acetate and interleukin 1beta by inhibiting the binding of CCAAT/enhancer-binding protein beta to its promoter region of COX-2.	Sodium Salicylate	29-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-94
11278846-2	2001	This study demonstrates that sodium salicylate at a therapeutic concentration suppressed COX-2 gene transcription induced by phorbol 12-myristate 13-acetate and interleukin 1beta by inhibiting the binding of CCAAT/enhancer-binding protein beta to its promoter region of COX-2.	Sodium Salicylate	29-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	270-275
11278846-2	2001	This study demonstrates that sodium salicylate at a therapeutic concentration suppressed COX-2 gene transcription induced by phorbol 12-myristate 13-acetate and interleukin 1beta by inhibiting the binding of CCAAT/enhancer-binding protein beta to its promoter region of COX-2.	Tetradecanoylphorbol Acetate	125-156	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-94
11278846-2	2001	This study demonstrates that sodium salicylate at a therapeutic concentration suppressed COX-2 gene transcription induced by phorbol 12-myristate 13-acetate and interleukin 1beta by inhibiting the binding of CCAAT/enhancer-binding protein beta to its promoter region of COX-2.	Tetradecanoylphorbol Acetate	125-156	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	270-275
11410236-5	2001	The LMCT (ligand-to-metal charge transition) bands of the Co(II)-HSA and Co(II)-BSA systems also show a kind of hypochromic effect featuring a dipole-dipole interaction mechanism.	lmct	4-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-64
11410236-5	2001	The LMCT (ligand-to-metal charge transition) bands of the Co(II)-HSA and Co(II)-BSA systems also show a kind of hypochromic effect featuring a dipole-dipole interaction mechanism.	lmct	4-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-79
11410236-5	2001	The LMCT (ligand-to-metal charge transition) bands of the Co(II)-HSA and Co(II)-BSA systems also show a kind of hypochromic effect featuring a dipole-dipole interaction mechanism.	dipole-dipole	143-156	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-64
11410236-5	2001	The LMCT (ligand-to-metal charge transition) bands of the Co(II)-HSA and Co(II)-BSA systems also show a kind of hypochromic effect featuring a dipole-dipole interaction mechanism.	dipole-dipole	143-156	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-79
11385114-1	2001	Human labour is associated with the up-regulation of prostaglandins within the uterus, synthesized via the type-2 cyclo-oxygenase enzyme (COX-2).	Prostaglandins	53-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	138-143
11455321-2	2001	The use of nimesulide, a COX-2 selective NSAID, has been recently proposed due to its capacity to selectively inhibit the enzyme expressed in the myometrium and endometrium.	nimesulide	11-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-30
11503270-4	2001	Selective COX-2 inhibitors i.e. meloxicam, nimesulid, etodolac or highly selective COX-2 inhibitors i.e. celecoxib, rofecoxib have antiinflammatory and analgesic properties with less or no gastrointestinal or other NSAIDs-typical adverse effects.	Meloxicam	32-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
11503270-4	2001	Selective COX-2 inhibitors i.e. meloxicam, nimesulid, etodolac or highly selective COX-2 inhibitors i.e. celecoxib, rofecoxib have antiinflammatory and analgesic properties with less or no gastrointestinal or other NSAIDs-typical adverse effects.	nimesulide	43-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
11469677-7	2001	A clear positive correlation between COX-2 expression and inhibition of apoptosis has been established, associated with increased PGE2 levels resulting in modulation of pro- and anti-apoptotic factors (e.g., bcl-2, MAKs/ras, caspase-3, Par-4).	Dinoprostone	130-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-42
11407522-4	2001	METHODS: PGE2 concentrations were measured in culture media from a highly COX-2-expressing human colon carcinoma cell line (CE-1) and other cell lines.	Dinoprostone	9-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
11412976-2	2001	The energetic and structural results point to the Ile to Val mutation at residue 523 as the key contributor to COX-2 selectivity; unfavorable steric contact between a sulfonamide oxygen and the delta methyl group of Ile523 destabilizes the complex with COX-1.	Sulfonamides	167-178	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	111-116
11412976-2	2001	The energetic and structural results point to the Ile to Val mutation at residue 523 as the key contributor to COX-2 selectivity; unfavorable steric contact between a sulfonamide oxygen and the delta methyl group of Ile523 destabilizes the complex with COX-1.	Oxygen	179-185	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	111-116
12585123-2	2001	METHODS: The interactions of the compound ZZ-122 with cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) were modeled by docking method.	zz-122	42-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-106
11798601-1	2001	OBJECTIVE: To investigate the mechanism of COX-2"s selective inhibitor, NS-398, on human colorectal adenoma development.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	72-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
12585123-3	2001	RESULTS: According to the binding pattern, intermolecular energy and capacity to form H-bond, it was easy for ZZ-122 to bind to COX-2 and not easy to COX-1.	zz-122	110-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	128-133
12585123-4	2001	CONCLUSION: Compound ZZ-122 may be a selective COX-2 inhibitor, which has to be confirmed by experiment.	zz-122	21-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
11278967-3	2001	Thus, we determined whether these fatty acids modulate LPS-induced signaling pathways and COX-2 expression in monocyte/macrophage cells (RAW 264.7).	Fatty Acids	34-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-95
11392547-0	2001	Thiazole analogues of the NSAID indomethacin as selective COX-2 inhibitors.	Thiazoles	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
11392547-0	2001	Thiazole analogues of the NSAID indomethacin as selective COX-2 inhibitors.	Indomethacin	32-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
11392547-1	2001	The carboxyl group of the NSAID indomethacin was replaced with a variety of substituted thiazoles to obtain a series of potent, selective inhibitors of COX-2.	Indomethacin	32-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-157
11392547-1	2001	The carboxyl group of the NSAID indomethacin was replaced with a variety of substituted thiazoles to obtain a series of potent, selective inhibitors of COX-2.	Thiazoles	88-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-157
11278967-6	2001	UFAs inhibit COX-2 expression induced by SFAs, constitutively active Tlr4, or LPS.	Fatty Acids, Unsaturated	0-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
11278967-8	2001	Together, these results suggest that both SFA-induced COX-2 expression and its inhibition by UFAs are mediated through a common signaling pathway derived from Tlr4.	Fatty Acids	42-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-59
11330996-9	2001	Considering only the high-affinity site, there is a diminution in the enthalpy of binding through the series Co(II) --&gt; Zn(II) --&gt; Cu(II) that mirrors the enthalpy of hydration; this observation reinforces the notion that the thermodynamics of solute association with water is at least as important as the thermodynamics of solute-solute interaction and that these effects must be considered when interpreting association in aqueous solution.	Zinc	123-129	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-115
11330996-9	2001	Considering only the high-affinity site, there is a diminution in the enthalpy of binding through the series Co(II) --&gt; Zn(II) --&gt; Cu(II) that mirrors the enthalpy of hydration; this observation reinforces the notion that the thermodynamics of solute association with water is at least as important as the thermodynamics of solute-solute interaction and that these effects must be considered when interpreting association in aqueous solution.	Water	274-279	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-115
11503270-4	2001	Selective COX-2 inhibitors i.e. meloxicam, nimesulid, etodolac or highly selective COX-2 inhibitors i.e. celecoxib, rofecoxib have antiinflammatory and analgesic properties with less or no gastrointestinal or other NSAIDs-typical adverse effects.	Etodolac	54-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
11503270-4	2001	Selective COX-2 inhibitors i.e. meloxicam, nimesulid, etodolac or highly selective COX-2 inhibitors i.e. celecoxib, rofecoxib have antiinflammatory and analgesic properties with less or no gastrointestinal or other NSAIDs-typical adverse effects.	Celecoxib	105-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
11503270-4	2001	Selective COX-2 inhibitors i.e. meloxicam, nimesulid, etodolac or highly selective COX-2 inhibitors i.e. celecoxib, rofecoxib have antiinflammatory and analgesic properties with less or no gastrointestinal or other NSAIDs-typical adverse effects.	Celecoxib	105-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
11503270-4	2001	Selective COX-2 inhibitors i.e. meloxicam, nimesulid, etodolac or highly selective COX-2 inhibitors i.e. celecoxib, rofecoxib have antiinflammatory and analgesic properties with less or no gastrointestinal or other NSAIDs-typical adverse effects.	rofecoxib	116-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
11457159-8	2001	That is, it is due to electron OMT via the half-filled d(z)(2) orbital present in Co(II) of CoTPP.	cobalt(III)-tetrakis(4-sulfonatophenyl)porphyrin	92-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-88
11330996-9	2001	Considering only the high-affinity site, there is a diminution in the enthalpy of binding through the series Co(II) --&gt; Zn(II) --&gt; Cu(II) that mirrors the enthalpy of hydration; this observation reinforces the notion that the thermodynamics of solute association with water is at least as important as the thermodynamics of solute-solute interaction and that these effects must be considered when interpreting association in aqueous solution.	cu(ii)	137-143	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-115
11323387-7	2001	Three hours after exposure to AA, the synthesis of PGE(2) via COX-2 was also increased.	Prostaglandins E	51-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
11501838-3	2001	The best known function of NSAIDs is to block the enzyme cyclooxygenase (Cox), the rate limiting enzyme in the conversion of arachidonic acid to prostaglandins.	Arachidonic Acid	125-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-76
11501838-3	2001	The best known function of NSAIDs is to block the enzyme cyclooxygenase (Cox), the rate limiting enzyme in the conversion of arachidonic acid to prostaglandins.	Prostaglandins	145-159	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-76
11501838-10	2001	We hypothesized that increased prostaglandin production by Cox-2 induces PKC and the expression of transcriptional factor c-Jun, which in turn, induces the expression of MDR1/Pgp170.	Prostaglandins	31-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-64
11377691-1	2001	The greater lability of Co(II) relative to Co(III) can potentially be used to achieve selective delivery of nitrogen mustard type molecules to hypoxic cells.	Nitrogen	108-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-30
11409487-0	2001	Eicosanoid production by human monocytes: does COX-2 contribute to a self-limiting inflammatory response?	Eicosanoids	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
11409487-4	2001	TXA2 synthesis is immediate and dependent on cyclooxygenase Type 1 (COX-1) activity whereas PGE2 synthesis is delayed and dependent on COX-2 activity.	Dinoprostone	92-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-140
11409487-6	2001	The findings have implications for the use of NSAIDs and selective COX-2 inhibitors whose actions can increase the monocyte TXA2/PGE2 ratio.	Dinoprostone	129-133	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-72
11457072-4	2001	Since EPR theory predicts an increase in Co(II) hyperfine splitting as donation from the axial N-donor ligand decreases, EPR spectroscopy could clarify the X-ray results.	Nitrogen	95-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-47
11287611-12	2001	The identification of distinct pathways through which eicosanoids regulate anti-inflammatory and antiproliferative effects may improve the utility of COX2 inhibitors.	Eicosanoids	54-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	150-154
11394934-3	2001	The clinical availability of new drugs able to produce a selective inhibition of type 2 cyclooxygenase (COX-2), the enzyme thought to be mainly responsible for generating arachidonic-acid-derived inflammatory mediators, has been the origin of much hope.	Arachidonic Acid	171-187	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
11413920-0	2001	[The selective Cox-2 inhibition by rofecoxib reduces risk of severe gastrointestinal complications of anti-inflammatory therapy by more than 50%].	rofecoxib	35-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-20
11327589-0	2001	In vitro metabolism considerations, including activity testing of metabolites, in the discovery and selection of the COX-2 inhibitor etoricoxib (MK-0663).	Etoricoxib	133-143	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-122
11327589-0	2001	In vitro metabolism considerations, including activity testing of metabolites, in the discovery and selection of the COX-2 inhibitor etoricoxib (MK-0663).	Etoricoxib	145-152	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-122
11327589-1	2001	Characterization of the metabolites of the COX-2 inhibitor etoricoxib (MK-0663 and L-791,456) produced in vitro indicate formation of an N-oxide pyridine and hydroxymethyl pyridine that can further be glucuronidated or oxidized to an acid.	Etoricoxib	59-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
11327589-1	2001	Characterization of the metabolites of the COX-2 inhibitor etoricoxib (MK-0663 and L-791,456) produced in vitro indicate formation of an N-oxide pyridine and hydroxymethyl pyridine that can further be glucuronidated or oxidized to an acid.	Etoricoxib	71-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
11327589-1	2001	Characterization of the metabolites of the COX-2 inhibitor etoricoxib (MK-0663 and L-791,456) produced in vitro indicate formation of an N-oxide pyridine and hydroxymethyl pyridine that can further be glucuronidated or oxidized to an acid.	l-791	83-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
11327589-1	2001	Characterization of the metabolites of the COX-2 inhibitor etoricoxib (MK-0663 and L-791,456) produced in vitro indicate formation of an N-oxide pyridine and hydroxymethyl pyridine that can further be glucuronidated or oxidized to an acid.	n-oxide pyridine	137-153	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
11327589-1	2001	Characterization of the metabolites of the COX-2 inhibitor etoricoxib (MK-0663 and L-791,456) produced in vitro indicate formation of an N-oxide pyridine and hydroxymethyl pyridine that can further be glucuronidated or oxidized to an acid.	hydroxymethyl pyridine	158-180	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
11457072-5	2001	However, the theory is apparently undermined by the similar splitting reported for the 2-picoline (2-pic) and pyridine (py) adducts of Co(II) cobinamide (Co(II)Cbi(+)), adducts thought to have long and normal Co-N axial bond lengths, respectively.	2-picoline	87-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-141
11457072-5	2001	However, the theory is apparently undermined by the similar splitting reported for the 2-picoline (2-pic) and pyridine (py) adducts of Co(II) cobinamide (Co(II)Cbi(+)), adducts thought to have long and normal Co-N axial bond lengths, respectively.	2-picoline	87-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-141
11457072-5	2001	However, the theory is apparently undermined by the similar splitting reported for the 2-picoline (2-pic) and pyridine (py) adducts of Co(II) cobinamide (Co(II)Cbi(+)), adducts thought to have long and normal Co-N axial bond lengths, respectively.	pyridine	110-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-141
11457072-5	2001	However, the theory is apparently undermined by the similar splitting reported for the 2-picoline (2-pic) and pyridine (py) adducts of Co(II) cobinamide (Co(II)Cbi(+)), adducts thought to have long and normal Co-N axial bond lengths, respectively.	pyridine	110-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-141
11457072-5	2001	However, the theory is apparently undermined by the similar splitting reported for the 2-picoline (2-pic) and pyridine (py) adducts of Co(II) cobinamide (Co(II)Cbi(+)), adducts thought to have long and normal Co-N axial bond lengths, respectively.	Cobalt(2+)	154-160	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-141
11457072-5	2001	However, the theory is apparently undermined by the similar splitting reported for the 2-picoline (2-pic) and pyridine (py) adducts of Co(II) cobinamide (Co(II)Cbi(+)), adducts thought to have long and normal Co-N axial bond lengths, respectively.	cobinamide	160-163	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-141
11457072-5	2001	However, the theory is apparently undermined by the similar splitting reported for the 2-picoline (2-pic) and pyridine (py) adducts of Co(II) cobinamide (Co(II)Cbi(+)), adducts thought to have long and normal Co-N axial bond lengths, respectively.	co-n	209-213	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-141
11405384-1	2001	This 6-week study was conducted to test the efficacy, safety, and tolerability of rofecoxib (a selective COX-2 inhibitor) compared to nabumetone (a non-selective NSAID) and placebo in osteoarthritis (OA) patients aged 80 and older.	rofecoxib	82-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-110
11284783-2	2001	AIM: To determine whether patients using the NSAID nabumetone, a non-acidic prodrug with mixed activity against cyclooxygenase-1 (COX-1) and COX-2, exhibited prolonged mucosal bleeding times and how this might compare with mucosal bleeding times in patients using aspirin.	Nabumetone	51-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	141-146
11290559-10	2001	We conclude that a decreased capacity to up-regulate COX-2 expression and COX-2-derived PGE(2) synthesis in the presence of increasing levels of profibrotic mediators such as TGF-beta(1) may lead to unopposed fibroblast proliferation and collagen synthesis and contribute to the pathogenesis of pulmonary fibrosis.	Prostaglandins E	88-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
11396478-3	2001	Furthermore, the product of iNOS catalysis, nitric oxide (NO), is an important regulator of COX-2 activity and expression, and the products of COX-1 and COX-2 (diverse prostanoids) may also influence iNOS expression.	Nitric Oxide	44-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-97
11316141-2	2001	As compared to conventional NSAIDs, celecoxib, a COX-2 specific inhibitor, has been shown in previous single posttreatment endoscopy studies to be associated with lower gastroduodenal ulcer rates.	Celecoxib	36-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-54
11396478-3	2001	Furthermore, the product of iNOS catalysis, nitric oxide (NO), is an important regulator of COX-2 activity and expression, and the products of COX-1 and COX-2 (diverse prostanoids) may also influence iNOS expression.	Prostaglandins	168-179	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	153-158
11273675-1	2001	Prostaglandins may influence cyclo-oxygenase (COX-2) and nitric oxide (NO) synthase activity, thus interfering with ischemia-induced neurotoxic processes.	Prostaglandins	0-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
11304122-3	2001	Since COX-2 reactions involve production of reactive oxygen radicals that can potentially damage biological macromolecules, we explored the possibility that DNA and/or nucleosides can be oxidized during cyclooxygenase reactions.	reactive oxygen radicals	44-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	6-11
11304122-4	2001	When DNA or nucleosides were incubated with COX-2 and arachidonic acid, a significant increase in the amount of 8-oxo-2"-deoxyguanosine was observed.	Nucleosides	12-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-49
11304122-4	2001	When DNA or nucleosides were incubated with COX-2 and arachidonic acid, a significant increase in the amount of 8-oxo-2"-deoxyguanosine was observed.	Arachidonic Acid	54-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-49
11304122-4	2001	When DNA or nucleosides were incubated with COX-2 and arachidonic acid, a significant increase in the amount of 8-oxo-2"-deoxyguanosine was observed.	8-ohdg	112-135	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-49
11273675-10	2001	The COX-2 activity in cultured retinal cells exposed to glutamate was measured as PGE2 production when latanoprost was applied compared to arachidonic acid (AA) at different molar concentrations.	Glutamic Acid	56-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
11273675-10	2001	The COX-2 activity in cultured retinal cells exposed to glutamate was measured as PGE2 production when latanoprost was applied compared to arachidonic acid (AA) at different molar concentrations.	Dinoprostone	82-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
11273675-10	2001	The COX-2 activity in cultured retinal cells exposed to glutamate was measured as PGE2 production when latanoprost was applied compared to arachidonic acid (AA) at different molar concentrations.	Latanoprost	103-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
11273675-10	2001	The COX-2 activity in cultured retinal cells exposed to glutamate was measured as PGE2 production when latanoprost was applied compared to arachidonic acid (AA) at different molar concentrations.	Arachidonic Acid	139-155	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
11273675-11	2001	The COX-2 activity was reduced by arachidonic acid (0.1-0.01 microM) as well as by latanoprost (0.1-0.001 microM) and PhXA85 (0.01-0.001 microM) in retinal cells exposed to glutamate.	Arachidonic Acid	34-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
11273675-11	2001	The COX-2 activity was reduced by arachidonic acid (0.1-0.01 microM) as well as by latanoprost (0.1-0.001 microM) and PhXA85 (0.01-0.001 microM) in retinal cells exposed to glutamate.	Latanoprost	83-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
11273675-11	2001	The COX-2 activity was reduced by arachidonic acid (0.1-0.01 microM) as well as by latanoprost (0.1-0.001 microM) and PhXA85 (0.01-0.001 microM) in retinal cells exposed to glutamate.	PhXa 85	118-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
11273675-11	2001	The COX-2 activity was reduced by arachidonic acid (0.1-0.01 microM) as well as by latanoprost (0.1-0.001 microM) and PhXA85 (0.01-0.001 microM) in retinal cells exposed to glutamate.	Glutamic Acid	173-182	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9
11266376-5	2001	COX-2 activity was assessed by measuring prostaglandin E(2) (PGE2) production by enzyme-linked immunosorbent assay.	Dinoprostone	41-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
11247889-11	2001	CONCLUSIONS: These findings provide the first evidence of COX-2 expression in neural cells of the myenteric plexus in active IBD which, via increased prostaglandin synthesis at this site, may contribute to the dysmotilty seen in this condition.	Prostaglandins	150-163	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
11266376-5	2001	COX-2 activity was assessed by measuring prostaglandin E(2) (PGE2) production by enzyme-linked immunosorbent assay.	Dinoprostone	61-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
11266376-8	2001	RESULTS: The PI 3-kinase inhibitor wortmannin up-regulated induced COX-2 expression in a concentration-dependent manner in both HT-29 and Caco-2 cells.	Wortmannin	35-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-72
11266376-9	2001	An alternative PI 3-kinase inhibitor, LY294002, caused up-regulation of induced COX-2 messenger RNA (mRNA) in HT-29 cells at concentrations of &lt; or =1 micromol/L.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-85
11383931-3	2001	Pharmacological COX-1 inhibition was performed with the prescription of acetylsalicylic acid (ASA) at a low dose, and COX-2 selective inhibition was performed with celecoxib.	Celecoxib	164-173	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-123
11383931-10	2001	In conclusion, COX-2-selective inhibitor at a celecoxib dose of 200 mg daily increased insulin sensitivity in healthy subjects.	Celecoxib	46-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-20
11376544-0	2001	Syntheses and structures of M(L)(X)BPh4 complexes (M = Co(II), Zn(II); L = cis-1,3,5-tris[3-(2-furyl)prop-2-enylideneamino]cyclohexane, X = OAc, NO3) n: structural models of the active site of carbonic anhydrase.	sapropterin	35-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-61
11327079-1	2001	The purpose of the present study was to investigate the involvement of cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) in prostaglandin (PG) production by human oral gingival epithelial (OGE) cells stimulated with proinflammatory cytokines including interleukin(IL)-1alpha, IL-1alpha and tumor necrosis factor alpha (TNFalpha), and serum.	Prostaglandins	128-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-123
11327079-4	2001	NS-398, a selective COX-2 inhibitor, inhibited PGE2 production by FBS-stimulated cells as completely as indomethacin, a non-selective COX-1/COX-2 inhibitor.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	0-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-25
11327079-4	2001	NS-398, a selective COX-2 inhibitor, inhibited PGE2 production by FBS-stimulated cells as completely as indomethacin, a non-selective COX-1/COX-2 inhibitor.	Dinoprostone	47-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-25
11338298-4	2001	COX-1 is constitutively expressed in various tissues whereas COX-2 is an inducible enzyme believed to be responsible for PG synthesis at sites of inflammation.	Prostaglandins	121-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-66
11327079-7	2001	We suggest that COX-2 is responsible for PG production by human OGE cells stimulated with serum and that OGE cells may be involved in PG production in periodontal lesions.	Prostaglandins	41-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-21
11338298-10	2001	COX-2 activity was assessed by quantifying prostaglandin E2 (PGE2) levels in culture supernatants by competitive EIA.	Dinoprostone	43-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
11338298-10	2001	COX-2 activity was assessed by quantifying prostaglandin E2 (PGE2) levels in culture supernatants by competitive EIA.	Dinoprostone	61-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
11718158-3	2001	(2) The clinical file on celecoxib, a drug promoted as a selective COX-2 inhibitor, is bulky but fails to answer several practical questions, mainly because it lacks comparative trials against paracetamol and low-dose NSAIDs.	Celecoxib	25-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-72
11338298-15	2001	COX-2 expression was upregulated as early as 2 hours post IL-1 beta challenge and was accompanied by a sustained PGE2 release in the culture supernatants.	Dinoprostone	113-117	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
11338298-17	2001	In contrast, NS-398, a selective inhibitor of COX-2 activity, almost completely abolished PGE2 synthesis by these cells in response to bacterial or cytokine challenge.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	13-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
11338298-17	2001	In contrast, NS-398, a selective inhibitor of COX-2 activity, almost completely abolished PGE2 synthesis by these cells in response to bacterial or cytokine challenge.	Dinoprostone	90-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
11367984-0	2001	[Effect of celecoxib, a COX-2 inhibitor, in familial adenomatous polyposis].	Celecoxib	11-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
11307496-5	2001	It induces prostaglandin synthesis via activation of COX-2.	Prostaglandins	11-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-58
11307498-4	2001	PROMISING PERSPECTIVES: COX-2 specific inhibitors, for example cerecoxib or rofecoxib, are potentially interesting for human therapy for chemoprevention of epithelial cancer or as medical treatment, alone or in combination with other anticancer treatments.	cerecoxib	63-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
11307498-4	2001	PROMISING PERSPECTIVES: COX-2 specific inhibitors, for example cerecoxib or rofecoxib, are potentially interesting for human therapy for chemoprevention of epithelial cancer or as medical treatment, alone or in combination with other anticancer treatments.	rofecoxib	76-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
11263799-1	2001	Prostaglandins produced by the COX-2 isoform of cyclooxygenase may be important for renal function--and perhaps even more so in diseases that render the kidney highly prostaglandin-dependent.	Prostaglandins	0-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-36
11263799-1	2001	Prostaglandins produced by the COX-2 isoform of cyclooxygenase may be important for renal function--and perhaps even more so in diseases that render the kidney highly prostaglandin-dependent.	Prostaglandins	167-180	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-36
11266647-3	2001	Indeed, development of the new "super aspirins," such as Celebrex and Vioxx, that selectively inhibit the inducible COX-2, expressed in areas of inflammation, is a direct outgrowth of this concept.	Aspirin	38-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-121
11266647-3	2001	Indeed, development of the new "super aspirins," such as Celebrex and Vioxx, that selectively inhibit the inducible COX-2, expressed in areas of inflammation, is a direct outgrowth of this concept.	Celecoxib	57-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-121
11266647-3	2001	Indeed, development of the new "super aspirins," such as Celebrex and Vioxx, that selectively inhibit the inducible COX-2, expressed in areas of inflammation, is a direct outgrowth of this concept.	rofecoxib	70-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-121
11370851-5	2001	Acetaminophen was found to be a good reducing agent of both oCOX-1 and hCOX-2.	Acetaminophen	0-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-77
11370851-4	2001	The potency of acetaminophen against both purified ovine cyclooxygenase-1 (oCOX-1) and human cyclooxygenase-2 (hCOX-2) was increased approximately 30-fold by the presence of glutathione peroxidase and glutathione to give IC50 values of 33 microM and 980 microM, respectively.	Acetaminophen	15-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	111-117
11370851-4	2001	The potency of acetaminophen against both purified ovine cyclooxygenase-1 (oCOX-1) and human cyclooxygenase-2 (hCOX-2) was increased approximately 30-fold by the presence of glutathione peroxidase and glutathione to give IC50 values of 33 microM and 980 microM, respectively.	Glutathione	174-185	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	111-117
11300882-3	2001	These pyrido[1,2-c]pyrimidines inhibited the generation of PGE(2) by COX-2 in RAW 264.7 macrophages stimulated with lipopolysaccharide.	octahydropyrido(1,2-c)pyrimidine	6-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-74
11300882-3	2001	These pyrido[1,2-c]pyrimidines inhibited the generation of PGE(2) by COX-2 in RAW 264.7 macrophages stimulated with lipopolysaccharide.	Prostaglandins E	59-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-74
11085996-1	2001	In vertebrates, the synthesis of prostaglandin hormones is catalyzed by cyclooxygenase (COX)-1, a constitutively expressed enzyme with physiological functions, and COX-2, induced in inflammation and cancer.	Prostaglandins	33-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	164-169
11085996-6	2001	A key amino acid that determines the sensitivity to selective COX-2 inhibitors (Ile(523) in COX-1 and Val(523) in COX-2) is present in coral COX as isoleucine.	Isoleucine	80-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
11085996-6	2001	A key amino acid that determines the sensitivity to selective COX-2 inhibitors (Ile(523) in COX-1 and Val(523) in COX-2) is present in coral COX as isoleucine.	Isoleucine	80-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-119
11085996-6	2001	A key amino acid that determines the sensitivity to selective COX-2 inhibitors (Ile(523) in COX-1 and Val(523) in COX-2) is present in coral COX as isoleucine.	Valine	102-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
11085996-6	2001	A key amino acid that determines the sensitivity to selective COX-2 inhibitors (Ile(523) in COX-1 and Val(523) in COX-2) is present in coral COX as isoleucine.	Valine	102-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-119
11085996-6	2001	A key amino acid that determines the sensitivity to selective COX-2 inhibitors (Ile(523) in COX-1 and Val(523) in COX-2) is present in coral COX as isoleucine.	Isoleucine	148-158	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
11085996-6	2001	A key amino acid that determines the sensitivity to selective COX-2 inhibitors (Ile(523) in COX-1 and Val(523) in COX-2) is present in coral COX as isoleucine.	Isoleucine	148-158	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-119
11085996-9	2001	The biosynthesis was inhibited by indomethacin, whereas the selective COX-2 inhibitor nimesulide was ineffective.	nimesulide	86-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-75
11171598-3	2001	The present study was performed to determine whether 17beta-estradiol (E2) enhances mechanical stress-induced prostaglandin production and cyclooxygenase (COX)-2 mRNA expression.	Estradiol	53-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-161
11171598-3	2001	The present study was performed to determine whether 17beta-estradiol (E2) enhances mechanical stress-induced prostaglandin production and cyclooxygenase (COX)-2 mRNA expression.	Estradiol	71-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-161
11357226-2	2001	In the present study the effects of biomedically relevant hexose sugars (glucose, fructose, galactose, mannose) and sucrose disaccharide on the expression of COX-1 and COX-2 genes were evaluated in granulation tissue fibroblasts, hypertrophic scar fibroblasts and keloid fibroblasts.	hexose sugars	58-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	168-173
11357226-2	2001	In the present study the effects of biomedically relevant hexose sugars (glucose, fructose, galactose, mannose) and sucrose disaccharide on the expression of COX-1 and COX-2 genes were evaluated in granulation tissue fibroblasts, hypertrophic scar fibroblasts and keloid fibroblasts.	Glucose	73-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	168-173
11357226-2	2001	In the present study the effects of biomedically relevant hexose sugars (glucose, fructose, galactose, mannose) and sucrose disaccharide on the expression of COX-1 and COX-2 genes were evaluated in granulation tissue fibroblasts, hypertrophic scar fibroblasts and keloid fibroblasts.	Fructose	82-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	168-173
11357226-2	2001	In the present study the effects of biomedically relevant hexose sugars (glucose, fructose, galactose, mannose) and sucrose disaccharide on the expression of COX-1 and COX-2 genes were evaluated in granulation tissue fibroblasts, hypertrophic scar fibroblasts and keloid fibroblasts.	Galactose	92-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	168-173
11357226-2	2001	In the present study the effects of biomedically relevant hexose sugars (glucose, fructose, galactose, mannose) and sucrose disaccharide on the expression of COX-1 and COX-2 genes were evaluated in granulation tissue fibroblasts, hypertrophic scar fibroblasts and keloid fibroblasts.	Mannose	103-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	168-173
11357226-2	2001	In the present study the effects of biomedically relevant hexose sugars (glucose, fructose, galactose, mannose) and sucrose disaccharide on the expression of COX-1 and COX-2 genes were evaluated in granulation tissue fibroblasts, hypertrophic scar fibroblasts and keloid fibroblasts.	sucrose disaccharide	116-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	168-173
11357226-7	2001	On the other hand, COX-2 mRNA expression in granulation tissue fibroblasts was decreased dramatically in the presence of fructose, mannose and sucrose and moderately in the presence of galactose.	Fructose	121-129	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-24
11357226-7	2001	On the other hand, COX-2 mRNA expression in granulation tissue fibroblasts was decreased dramatically in the presence of fructose, mannose and sucrose and moderately in the presence of galactose.	Mannose	131-138	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-24
11357226-7	2001	On the other hand, COX-2 mRNA expression in granulation tissue fibroblasts was decreased dramatically in the presence of fructose, mannose and sucrose and moderately in the presence of galactose.	Sucrose	143-150	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-24
11357226-7	2001	On the other hand, COX-2 mRNA expression in granulation tissue fibroblasts was decreased dramatically in the presence of fructose, mannose and sucrose and moderately in the presence of galactose.	Galactose	185-194	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-24
11248679-11	2001	The absorption spectra of the adducts of Co(II)-substituted NGCA with acetazolamide, NCO(-), SCN(-), CN(-) and N(3)(-) resemble the corresponding spectra obtained with human Co(II)-isozymes I and II.	Acetazolamide	70-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-46
11231941-9	2001	Naproxen also significantly inhibited both serum TXB2 by 94% and LPS-induced PGE2 production by 77% (both P &lt; or = 0.002 vs. placebo), but rofecoxib only inhibited COX-2-dependent LPS-induced PGE(2) (by 79%; P &lt; 0.001 vs. placebo).	rofecoxib	142-151	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	167-172
11171823-0	2001	Selective inhibition of COX-2 in humans is associated with less gastrointestinal injury: a comparison of nimesulide and naproxen.	nimesulide	105-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
11171823-0	2001	Selective inhibition of COX-2 in humans is associated with less gastrointestinal injury: a comparison of nimesulide and naproxen.	Naproxen	120-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
11171823-2	2001	AIMS: We compared the biochemical and gastrointestinal effects of nimesulide, a potent and selective COX-2 inhibitor, with naproxen which exhibits no selectivity.	nimesulide	66-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-106
11171823-12	2001	COX-2 activity, determined as endotoxin induced prostaglandin E(2) formation in plasma, was markedly suppressed by both treatments.	Dinoprostone	48-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
11171823-13	2001	INTERPRETATION: Nimesulide has preferential selectivity for COX-2 over COX-1 in vivo at full therapeutic doses and induces less gastrointestinal damage than that seen with naproxen in the short term.	nimesulide	16-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-65
11230753-9	2001	Pretreatment of HSC with the stable cyclic adenosine monophosphate (cAMP) analog, 8-bromo cAMP, reverted the effects of the COX-2 inhibitor, but not of a nuclear factor-kappaB (NF-kappaB) inhibitor, demonstrating that prostaglandins modulate MCP-1 expression via production of cAMP.	Cyclic AMP	90-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	124-129
11330469-0	2001	Ester hydrolysis with 2,6-di(pyrazol-3-yl)pyridines and their CoII complexes in homogeneous and micellar media.	Esters	0-5	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-66
11330469-0	2001	Ester hydrolysis with 2,6-di(pyrazol-3-yl)pyridines and their CoII complexes in homogeneous and micellar media.	2,6-di(pyrazol-3-yl)pyridines	22-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-66
11179444-2	2001	TNF-alpha-mediated COX-2 expression and COX-2 promoter activity were inhibited by the MAPK kinase inhibitor PD98059 or the p38 inhibitor SB203580.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	108-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-24
11179444-2	2001	TNF-alpha-mediated COX-2 expression and COX-2 promoter activity were inhibited by the MAPK kinase inhibitor PD98059 or the p38 inhibitor SB203580.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	108-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
11179444-2	2001	TNF-alpha-mediated COX-2 expression and COX-2 promoter activity were inhibited by the MAPK kinase inhibitor PD98059 or the p38 inhibitor SB203580.	SB 203580	137-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-24
11179444-2	2001	TNF-alpha-mediated COX-2 expression and COX-2 promoter activity were inhibited by the MAPK kinase inhibitor PD98059 or the p38 inhibitor SB203580.	SB 203580	137-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
11179444-6	2001	SMase- or C2-ceramide-induced COX-2 expression and COX-2 promoter activity were also inhibited by PD98059 or SB203580.	N-acetylsphingosine	10-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-35
11179444-6	2001	SMase- or C2-ceramide-induced COX-2 expression and COX-2 promoter activity were also inhibited by PD98059 or SB203580.	N-acetylsphingosine	10-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-56
11179444-6	2001	SMase- or C2-ceramide-induced COX-2 expression and COX-2 promoter activity were also inhibited by PD98059 or SB203580.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	98-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-35
11179444-6	2001	SMase- or C2-ceramide-induced COX-2 expression and COX-2 promoter activity were also inhibited by PD98059 or SB203580.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	98-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-56
11179444-6	2001	SMase- or C2-ceramide-induced COX-2 expression and COX-2 promoter activity were also inhibited by PD98059 or SB203580.	SB 203580	109-117	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-35
11179444-6	2001	SMase- or C2-ceramide-induced COX-2 expression and COX-2 promoter activity were also inhibited by PD98059 or SB203580.	SB 203580	109-117	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-56
11179444-7	2001	Glutathione, a neutral SMase inhibitor, attenuated TNF-alpha- or SMase-induced activation of MAPKs, COX-2 expression, and COX-2 promoter activity.	Glutathione	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-105
11179444-7	2001	Glutathione, a neutral SMase inhibitor, attenuated TNF-alpha- or SMase-induced activation of MAPKs, COX-2 expression, and COX-2 promoter activity.	Glutathione	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-127
11179444-8	2001	TNF-alpha- or C2-ceramide-induced COX-2 promoter activity was inhibited by the dominant negative mutant of extracellular signal-regulated kinase 2, p38, JNK, IkappaB kinase (IKK)1, or IKK2.	N-acetylsphingosine	14-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-39
11179444-10	2001	All these results suggest that, in NCI-H292 epithelial cells, activation of MAPKs by ceramide contributes to the TNF-alpha signaling that occurs downstream of neutral SMase activation and results in the stimulation of IKK1/2, and NF-kappaB in the COX-2 promoter, followed by initiation of COX-2 expression.	Ceramides	85-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	247-252
11179444-10	2001	All these results suggest that, in NCI-H292 epithelial cells, activation of MAPKs by ceramide contributes to the TNF-alpha signaling that occurs downstream of neutral SMase activation and results in the stimulation of IKK1/2, and NF-kappaB in the COX-2 promoter, followed by initiation of COX-2 expression.	Ceramides	85-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	289-294
11300551-1	2001	The preparation of 2-thiouracil (H2L) and its 5-(2-thiazolylazo)thiouracil (H2L") complexes with CoII, NiII, CuII, ZnII and CdII are reported.	Thiouracil	19-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-101
11300551-1	2001	The preparation of 2-thiouracil (H2L) and its 5-(2-thiazolylazo)thiouracil (H2L") complexes with CoII, NiII, CuII, ZnII and CdII are reported.	h2l	33-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-101
11300551-1	2001	The preparation of 2-thiouracil (H2L) and its 5-(2-thiazolylazo)thiouracil (H2L") complexes with CoII, NiII, CuII, ZnII and CdII are reported.	5-(2-thiazolylazo)thiouracil	46-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-101
11300551-1	2001	The preparation of 2-thiouracil (H2L) and its 5-(2-thiazolylazo)thiouracil (H2L") complexes with CoII, NiII, CuII, ZnII and CdII are reported.	h2l"	76-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-101
11094054-0	2001	Prostaglandin levels in stimulated macrophages are controlled by phospholipase A2-activating protein and by activation of phospholipase C and D. Prostaglandins (PG), which are responsible for a large array of biological functions in eukaryotic cells, are produced from arachidonic acid by phospholipases and cyclooxygenase enzymes COX-1 and COX-2.	Prostaglandins	145-159	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	341-346
11094054-0	2001	Prostaglandin levels in stimulated macrophages are controlled by phospholipase A2-activating protein and by activation of phospholipase C and D. Prostaglandins (PG), which are responsible for a large array of biological functions in eukaryotic cells, are produced from arachidonic acid by phospholipases and cyclooxygenase enzymes COX-1 and COX-2.	Prostaglandins	161-163	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	341-346
11173047-1	2001	Cyclooxygenase (COX)-1 and COX-2 catalyze the formation of prothrombotic and antithrombotic eicosanoids, respectively.	Eicosanoids	92-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-32
11173047-2	2001	Aspirin, conventional nonsteroidal anti-inflammatory drugs (NSAIDs), and COX-2-specific inhibitors exhibit different patterns of inhibition of COX-1-mediated thromboxane biosynthesis and COX-2-mediated prostacyclin biosynthesis.	Aspirin	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	187-192
11173047-2	2001	Aspirin, conventional nonsteroidal anti-inflammatory drugs (NSAIDs), and COX-2-specific inhibitors exhibit different patterns of inhibition of COX-1-mediated thromboxane biosynthesis and COX-2-mediated prostacyclin biosynthesis.	Thromboxanes	158-169	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-78
11173047-2	2001	Aspirin, conventional nonsteroidal anti-inflammatory drugs (NSAIDs), and COX-2-specific inhibitors exhibit different patterns of inhibition of COX-1-mediated thromboxane biosynthesis and COX-2-mediated prostacyclin biosynthesis.	Epoprostenol	202-214	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-78
11173047-2	2001	Aspirin, conventional nonsteroidal anti-inflammatory drugs (NSAIDs), and COX-2-specific inhibitors exhibit different patterns of inhibition of COX-1-mediated thromboxane biosynthesis and COX-2-mediated prostacyclin biosynthesis.	Epoprostenol	202-214	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	187-192
11225126-1	2001	Transition-metal-substituted polyoxometalates (TMSP) of the type [MII(H2O)PW11O39]5- (M = Co, Zn) and [SiW9O37(CoII(H2O))3]10- have been chemically anchored to modified macroporous (400 nm pores), mesoporous (2.8 nm pores), and amorphous silica surfaces.	Metals	11-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	111-115
11225126-1	2001	Transition-metal-substituted polyoxometalates (TMSP) of the type [MII(H2O)PW11O39]5- (M = Co, Zn) and [SiW9O37(CoII(H2O))3]10- have been chemically anchored to modified macroporous (400 nm pores), mesoporous (2.8 nm pores), and amorphous silica surfaces.	polyoxometalate I	29-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	111-115
11159881-4	2001	RESULTS: The luminal compounds deoxycholate, chenodeoxycholate, and butyrate all induced COX-2 promoter activity in HCT 116 cells.	Butyrates	68-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-94
11457159-1	2001	Thin films of vapor-deposited Ni(II) and Co(II) complexes of tetraphenylporphyrin (NiTPP and CoTPP) were studied supported on gold and embedded in Al-Al(2)O(3)-MTPP-Pb tunnel diodes, where M = Ni or Co.	tetraphenylporphyrin	61-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-47
11457159-1	2001	Thin films of vapor-deposited Ni(II) and Co(II) complexes of tetraphenylporphyrin (NiTPP and CoTPP) were studied supported on gold and embedded in Al-Al(2)O(3)-MTPP-Pb tunnel diodes, where M = Ni or Co.	nitpp	83-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-47
11457159-1	2001	Thin films of vapor-deposited Ni(II) and Co(II) complexes of tetraphenylporphyrin (NiTPP and CoTPP) were studied supported on gold and embedded in Al-Al(2)O(3)-MTPP-Pb tunnel diodes, where M = Ni or Co.	cobalt(III)-tetrakis(4-sulfonatophenyl)porphyrin	93-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-47
11457159-8	2001	That is, it is due to electron OMT via the half-filled d(z)(2) orbital present in Co(II) of CoTPP.	omt	31-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-88
11166911-4	2001	Inhibition of PGE(2) production was caused by 4-HPR in a concentration-dependent manner and decreased COX-2 but not COX-1 mRNA levels; this is the first indication that 4-HPR selectively inhibits COX-2 gene expression.	Dinoprostone	14-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-107
11166911-4	2001	Inhibition of PGE(2) production was caused by 4-HPR in a concentration-dependent manner and decreased COX-2 but not COX-1 mRNA levels; this is the first indication that 4-HPR selectively inhibits COX-2 gene expression.	Dinoprostone	14-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	196-201
11248083-2	2001	Biochemically selective inhibition of COX-2 reduces PGI(2) biosynthesis substantially in humans.	Epoprostenol	52-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-43
11300810-1	2001	(1/2)H2O and in the spin crossover complexes [Co(II)(terpy)2]X2.nH2O (X = Cl and ClO4): a Mossbauer emission spectroscopic study.	Water	5-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
11300810-1	2001	(1/2)H2O and in the spin crossover complexes [Co(II)(terpy)2]X2.nH2O (X = Cl and ClO4): a Mossbauer emission spectroscopic study.	nh2o	64-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
11300810-1	2001	(1/2)H2O and in the spin crossover complexes [Co(II)(terpy)2]X2.nH2O (X = Cl and ClO4): a Mossbauer emission spectroscopic study.	perchlorate	81-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
29712162-1	2001	mu4 end-on coordination (through the N atom) of the pseudohalogeno ligands X- =N3- and NCO- has been observed in the isostructural nonanuclear CoII cages with the general formula [Co9 {(2-C5 H4 N)2 CO2 }4 (O2 CMe)8 X2 ]; this mode is imposed by the trapping of anions X- into cavities formed inside the cage.	Nitrogen	37-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	143-147
29712162-1	2001	mu4 end-on coordination (through the N atom) of the pseudohalogeno ligands X- =N3- and NCO- has been observed in the isostructural nonanuclear CoII cages with the general formula [Co9 {(2-C5 H4 N)2 CO2 }4 (O2 CMe)8 X2 ]; this mode is imposed by the trapping of anions X- into cavities formed inside the cage.	1-({2-[(1s)-1-Aminoethyl]-1,3-Oxazol-4-Yl}carbonyl)-L-Prolyl-L-Tryptophan	180-183	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	143-147
11284325-6	2001	The performance of the system was illustrated by the separation of Co(II) and Cu(II), achieving baseline separation in 60 s. Detection limits (3 sigma) were 1.25 x 10(-8) and 2.3 x 10(-6) mol dm-3 for Co(II) and Cu(II), respectively.	cu(ii)	78-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	201-207
11284325-6	2001	The performance of the system was illustrated by the separation of Co(II) and Cu(II), achieving baseline separation in 60 s. Detection limits (3 sigma) were 1.25 x 10(-8) and 2.3 x 10(-6) mol dm-3 for Co(II) and Cu(II), respectively.	Dm-3	192-196	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-73
11284325-6	2001	The performance of the system was illustrated by the separation of Co(II) and Cu(II), achieving baseline separation in 60 s. Detection limits (3 sigma) were 1.25 x 10(-8) and 2.3 x 10(-6) mol dm-3 for Co(II) and Cu(II), respectively.	cu(ii)	212-218	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-73
11243876-0	2001	Signaling mechanism underlying COX-2 induction by lysophosphatidylcholine.	Lysophosphatidylcholines	50-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-36
11318071-3	2001	OBJECTIVE: Because more data are now available on efficacy and safety issues with COX-2-selective inhibitors, NSAIDs, and acetaminophen, this review focuses on how COX-2-selective inhibitors may change the pharmacologic management of patients with OA.	Acetaminophen	122-135	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	164-169
11318071-5	2001	CONCLUSIONS: The safety and efficacy of two COX-2-selective inhibitors, rofecoxib and celecoxib, have been examined in a number of clinical trials, and these agents have been shown to offer efficacy similar to that of NSAIDs.	rofecoxib	72-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-49
11318071-5	2001	CONCLUSIONS: The safety and efficacy of two COX-2-selective inhibitors, rofecoxib and celecoxib, have been examined in a number of clinical trials, and these agents have been shown to offer efficacy similar to that of NSAIDs.	Celecoxib	86-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-49
11318071-7	2001	COX-2-selective inhibitors should be considered in patients with OA who do not respond to or cannot tolerate therapy with acetaminophen.	Acetaminophen	122-135	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
12783090-8	2001	In contrast to COX-1, COX-2 is strongly inducible by a variety of mitogens such as cytokines and growth factors, and plays a key role in the production of inflammatory prostaglandins.	Prostaglandins	168-182	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-27
11231941-1	2001	BACKGROUND &amp; AIMS: Rofecoxib, an inhibitor of the inducible cyclooxygenase (COX)-2 enzyme, appears not to cause acute gastroduodenal injury or chronic ulceration.	rofecoxib	23-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-86
11230753-5	2001	NS-398, a specific COX-2 inhibitor, also resulted in a dose-dependent inhibition of MCP-1 gene and protein expression.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	0-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-24
11230753-9	2001	Pretreatment of HSC with the stable cyclic adenosine monophosphate (cAMP) analog, 8-bromo cAMP, reverted the effects of the COX-2 inhibitor, but not of a nuclear factor-kappaB (NF-kappaB) inhibitor, demonstrating that prostaglandins modulate MCP-1 expression via production of cAMP.	Cyclic AMP	36-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	124-129
11230753-9	2001	Pretreatment of HSC with the stable cyclic adenosine monophosphate (cAMP) analog, 8-bromo cAMP, reverted the effects of the COX-2 inhibitor, but not of a nuclear factor-kappaB (NF-kappaB) inhibitor, demonstrating that prostaglandins modulate MCP-1 expression via production of cAMP.	Cyclic AMP	68-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	124-129
11230753-9	2001	Pretreatment of HSC with the stable cyclic adenosine monophosphate (cAMP) analog, 8-bromo cAMP, reverted the effects of the COX-2 inhibitor, but not of a nuclear factor-kappaB (NF-kappaB) inhibitor, demonstrating that prostaglandins modulate MCP-1 expression via production of cAMP.	8-Bromo Cyclic Adenosine Monophosphate	82-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	124-129
11324626-4	2001	By using Job"s method of continuous variation, the stoichiometry of the reaction was found to be in the ratio of 1:2, metal:drug, with Cu(II) and Co(II).	Metals	118-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	146-152
11370818-7	2001	Interestingly, cox-1, the other isozyme that is expressed in tumor vascular endothelia, participates in tumor angiogenesis, because an anti-sense oligonucleotide of cox-1 suppresses in vitro angiogenesis induced by cox-2-overexpressing cells.	Oligonucleotides	146-161	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	215-220
11370818-10	2001	Furthermore, another concept is emerging to indicate that prostaglandins (COX-2 products and mediators of classic inflammation) suppress host immunity against tumors.	Prostaglandins	58-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
11238720-12	2001	NS-398, a selective COX2 blocker, completely inhibited ethanol-induced alterations in COX activity.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	0-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-24
11238720-12	2001	NS-398, a selective COX2 blocker, completely inhibited ethanol-induced alterations in COX activity.	Ethanol	55-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-24
11238720-15	2001	Thus, astrocytes are a primary target of ethanol and ethanol-induced increases in glial PGE(2) synthesis are mediated by COX, principally COX2.	Ethanol	53-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	138-142
11238720-15	2001	Thus, astrocytes are a primary target of ethanol and ethanol-induced increases in glial PGE(2) synthesis are mediated by COX, principally COX2.	Dinoprostone	88-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	138-142
11301836-9	2001	Included are the rationale for use of such agents, results of a study showing a significant reduction in adenoma burden in familial adenomatous polyposis patients who received the selective COX-2 inhibitor celecoxib (Celebrex), and the design of other ongoing or planned clinical trials.	Celecoxib	206-215	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	190-195
11301836-9	2001	Included are the rationale for use of such agents, results of a study showing a significant reduction in adenoma burden in familial adenomatous polyposis patients who received the selective COX-2 inhibitor celecoxib (Celebrex), and the design of other ongoing or planned clinical trials.	Celecoxib	217-225	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	190-195
11094054-0	2001	Prostaglandin levels in stimulated macrophages are controlled by phospholipase A2-activating protein and by activation of phospholipase C and D. Prostaglandins (PG), which are responsible for a large array of biological functions in eukaryotic cells, are produced from arachidonic acid by phospholipases and cyclooxygenase enzymes COX-1 and COX-2.	Prostaglandins	0-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	341-346
11456660-4	2001	P-1[Co(II)] has a significantly higher affinity for NO compared to O(2), CO(2), and CO.	o(2)	67-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
11456660-4	2001	P-1[Co(II)] has a significantly higher affinity for NO compared to O(2), CO(2), and CO.	co(2)	73-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
11456660-4	2001	P-1[Co(II)] has a significantly higher affinity for NO compared to O(2), CO(2), and CO.	Carbon Monoxide	73-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
11456660-5	2001	The polymer is synthesized by template copolymerization methods and consists of a porous methacrylate network, containing immobilized four-coordinate Co(II) sites.	Polymers	4-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	150-156
11456660-5	2001	The polymer is synthesized by template copolymerization methods and consists of a porous methacrylate network, containing immobilized four-coordinate Co(II) sites.	Methacrylates	89-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	150-156
11456660-8	2001	Electronic and X-ray absorbance results for P-1[Co(II)] and P-1[Co(NO)] show that the coordination geometry of the immobilized cobalt complexes are similar to those of their monomeric analogues and that NO binds directly to the cobalt centers.	Cobalt	127-133	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-54
11158990-6	2001	The nonselective cyclooxygenase (COX) inhibitor indomethacin (5 microM) and the selective COX-2 inhibitor NS-398 (5 microM) potentiated the stimulatory effect of VEGF, whereas the selective COX-1 inhibitor resveratrol (5 microM) was without effect.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	106-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-95
11159047-7	2001	Preventing the expression of Cox-2 by dexamethasone or blocking Cox-2 activity with the selective Cox-2 inhibitor NS398 attenuated both thromboxane formation and bronchoconstriction.	Dexamethasone	38-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34
11159047-7	2001	Preventing the expression of Cox-2 by dexamethasone or blocking Cox-2 activity with the selective Cox-2 inhibitor NS398 attenuated both thromboxane formation and bronchoconstriction.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	114-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34
11159047-7	2001	Preventing the expression of Cox-2 by dexamethasone or blocking Cox-2 activity with the selective Cox-2 inhibitor NS398 attenuated both thromboxane formation and bronchoconstriction.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	114-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-69
11159047-7	2001	Preventing the expression of Cox-2 by dexamethasone or blocking Cox-2 activity with the selective Cox-2 inhibitor NS398 attenuated both thromboxane formation and bronchoconstriction.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	114-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-69
11159047-7	2001	Preventing the expression of Cox-2 by dexamethasone or blocking Cox-2 activity with the selective Cox-2 inhibitor NS398 attenuated both thromboxane formation and bronchoconstriction.	Thromboxanes	136-147	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34
11159047-7	2001	Preventing the expression of Cox-2 by dexamethasone or blocking Cox-2 activity with the selective Cox-2 inhibitor NS398 attenuated both thromboxane formation and bronchoconstriction.	Thromboxanes	136-147	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-69
11159047-7	2001	Preventing the expression of Cox-2 by dexamethasone or blocking Cox-2 activity with the selective Cox-2 inhibitor NS398 attenuated both thromboxane formation and bronchoconstriction.	Thromboxanes	136-147	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-69
11215533-0	2001	Serotonin-induced human coronary microvascular contraction during acute myocardial ischemia is blocked by COX-2 inhibition.	Serotonin	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-111
11251623-0	2001	Safety of a specific COX-2 inhibitor in aspirin-induced asthma.	Aspirin	40-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-26
11251623-1	2001	In a subset of patients with asthma, aspirin and several other non-steroidal anti-inflammatory drugs (NSAID) that inhibit simultaneously cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) precipitate dangerous asthmatic attacks.	Aspirin	37-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	184-189
11159881-1	2001	BACKGROUND &amp; AIMS: Evidence is accumulating that inhibitors of cyclooxygenase (COX)-2 activity are useful for preventing human colon cancer.	Adenosine Monophosphate	12-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-89
11159881-4	2001	RESULTS: The luminal compounds deoxycholate, chenodeoxycholate, and butyrate all induced COX-2 promoter activity in HCT 116 cells.	Deoxycholic Acid	31-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-94
11159881-4	2001	RESULTS: The luminal compounds deoxycholate, chenodeoxycholate, and butyrate all induced COX-2 promoter activity in HCT 116 cells.	Chenodeoxycholic Acid	45-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-94
11286400-2	2001	In a recombinant human cyclooxygenase (COX) enzyme activity, FR188582 inhibited COX-2 with an IC50 value of 0.017 microM, and the inhibition of prostaglandin (PG) E2 formation by FR188582 was over 6000 times more selective for COX-2 than COX-1.	3-chloro-5-(4-(methylsulfonyl)phenyl)-1-phenyl-1H-pyrazole	61-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-85
11286400-2	2001	In a recombinant human cyclooxygenase (COX) enzyme activity, FR188582 inhibited COX-2 with an IC50 value of 0.017 microM, and the inhibition of prostaglandin (PG) E2 formation by FR188582 was over 6000 times more selective for COX-2 than COX-1.	3-chloro-5-(4-(methylsulfonyl)phenyl)-1-phenyl-1H-pyrazole	61-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	227-232
11235048-3	2001	Current prescribing information warns to avoid using COX-2 inhibitors in aspirin-sensitive asthma patients.	Aspirin	73-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-58
11235048-4	2001	New evidence suggests that aspirin sensitivity may be linked to the COX-1 pathway, and COX-2 inhibitors, as a result of their selectivity, may be beneficial in patients with aspirin-induced asthma.	Aspirin	174-181	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-92
11310210-1	2001	The enzymes cyclooxygenase-1 (Cox-1) and cyclooxygenase-2 (Cox-2) catalyze the initial step in the formation of prostaglandins (PGs).	Prostaglandins	112-126	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-64
11310210-1	2001	The enzymes cyclooxygenase-1 (Cox-1) and cyclooxygenase-2 (Cox-2) catalyze the initial step in the formation of prostaglandins (PGs).	Prostaglandins	128-131	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-64
11310210-3	2001	The formation of PGs is stimulated in various cancers since the expression of Cox-2 is upregulated.	Prostaglandins	17-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-83