PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
2587251-4	1989	In contrast, 2-(4-methyl-2,6-dinitroanilino)-N-methylpropionamide, (MDMP), which inhibits initiation, greatly reduces the density of ribosomes on vitellogenin mRNA, and completely blocks estrogen-mediated stabilization.	2-(4-methyl-2,6-dinitroanilino)-N-methylpropionamide	13-65	a1-a	Xenopus laevis	146-158
2587251-4	1989	In contrast, 2-(4-methyl-2,6-dinitroanilino)-N-methylpropionamide, (MDMP), which inhibits initiation, greatly reduces the density of ribosomes on vitellogenin mRNA, and completely blocks estrogen-mediated stabilization.	2-(4-methyl-2,6-dinitroanilino)-N-methylpropionamide	68-72	a1-a	Xenopus laevis	146-158
2587251-8	1989	Vitellogenin mRNA in MDMP-treated cells remains associated with the endoplasmic reticulum in small polysomes containing 3-5 ribosomes.	2-(4-methyl-2,6-dinitroanilino)-N-methylpropionamide	21-25	a1-a	Xenopus laevis	0-12
3315227-3	1987	We identified two inhibitors of VTG processing into the yolk proteins: the ionophore monensin and pepstatin A, a specific inhibitor of cathepsin D.	pepstatin	98-109	a1-a	Xenopus laevis	32-35
2701940-8	1989	A putative asparagine-linked N-glycosylation site which was conserved in the chicken vitellogenin II and the Xenopus laevis vitellogenin A2 gene, at the beginning of exon 23, is also present in vitellogenin III.	Asparagine	11-21	a1-a	Xenopus laevis	85-97
2701940-8	1989	A putative asparagine-linked N-glycosylation site which was conserved in the chicken vitellogenin II and the Xenopus laevis vitellogenin A2 gene, at the beginning of exon 23, is also present in vitellogenin III.	Nitrogen	29-30	a1-a	Xenopus laevis	85-97
2431937-7	1987	The use of VG-Au particles of two sizes demonstrates that gold particles in early MVBs were generally associated with the limiting membrane of these organelles, while older MVB compartments have gold particles well separated from the limiting membranes, suggesting that dissociation of VG from its receptor occurs in this compartment.	Gold	14-16	a1-a	Xenopus laevis	11-13
3667603-2	1987	After internalization by receptor-mediated endocytosis, vitellogenin is delivered to a final storage compartment in mature, high density (1.23 g/ml sucrose) yolk platelets by a biphasic transport pathway.	Sucrose	148-155	a1-a	Xenopus laevis	56-68
3601655-6	1987	Comparison of the amino acid sequence of the vitellogenin A2 molecule with biochemical data obtained from the different yolk proteins allowed us to localize the cleavage products on the vitellogenin precursor as follows: NH2 - lipovitellin I - phosvitin (or phosvette II - phosvette I) - lipovitellin II - COOH.	phosvette ii - phosvette i)	258-285	a1-a	Xenopus laevis	45-57
3601655-6	1987	Comparison of the amino acid sequence of the vitellogenin A2 molecule with biochemical data obtained from the different yolk proteins allowed us to localize the cleavage products on the vitellogenin precursor as follows: NH2 - lipovitellin I - phosvitin (or phosvette II - phosvette I) - lipovitellin II - COOH.	lipovitellin ii	288-303	a1-a	Xenopus laevis	45-57
3601655-6	1987	Comparison of the amino acid sequence of the vitellogenin A2 molecule with biochemical data obtained from the different yolk proteins allowed us to localize the cleavage products on the vitellogenin precursor as follows: NH2 - lipovitellin I - phosvitin (or phosvette II - phosvette I) - lipovitellin II - COOH.	Carbonic Acid	306-310	a1-a	Xenopus laevis	45-57
3582729-1	1987	We have previously demonstrated that injection of adult male frogs with estradiol-17 beta causes extensive proliferation of liver parenchymal cells together with the induction of vitellogenin (R. J. Spolski, W. Schneider, and L. J. Wangh (1985) Dev.	Estradiol	72-89	a1-a	Xenopus laevis	179-191
3030694-2	1987	However, administration of estradiol results in a rapid 2- to 5-fold increase in cellular estrogen receptor content concurrent with the de novo transcriptional activation of the genes for the yolk protein precursor vitellogenin.	Estradiol	27-36	a1-a	Xenopus laevis	215-227
3454873-3	1987	Administration of 4-hydroxytamoxifen 24 h before estradiol completely blocked both the suppression of albumin mRNA and the transcriptional activation of the vitellogenin genes.	hydroxytamoxifen	18-36	a1-a	Xenopus laevis	157-169
3116270-0	1987	The distribution of the dinucleotide CpG and cytosine methylation in the vitellogenin gene family.	Dinucleoside Phosphates	24-36	a1-a	Xenopus laevis	73-85
3116270-0	1987	The distribution of the dinucleotide CpG and cytosine methylation in the vitellogenin gene family.	Cytosine	45-53	a1-a	Xenopus laevis	73-85
3582267-3	1986	Using this procedure, 934 mg vitellogenin was purified from 49 ml of estradiol treated female Xenopus plasma (about 19 mg/ml).	Estradiol	69-78	a1-a	Xenopus laevis	29-41
3582267-9	1986	Vitellogenin content was increased gradually during the first 6 days after injection of estradiol in female and the elevated level of vitellogenin dropped afterward.	Estradiol	88-97	a1-a	Xenopus laevis	0-12
3733641-1	1986	We have recently shown that extensive proliferation of liver parenchymal cells takes place in adult male Xenopus frogs in response to estradiol-17 beta, which also induces synthesis and secretion of vitellogenin, the precursor of yolk proteins.	Estradiol	134-151	a1-a	Xenopus laevis	199-211
3733641-5	1986	Estradiol-17 beta causes a dose-dependent increase in the number of cells synthesizing DNA, as well as inducing synthesis of vitellogenin.	Estradiol	0-17	a1-a	Xenopus laevis	125-137
6510549-4	1984	In parallel cultures, the absolute rate of vitellogenin gene transcription was determined by hybridization of newly synthesized RNA pulse-labelled with [3H]uridine to cloned Xenopus vitellogenin cDNA.	[3h]uridine	152-163	a1-a	Xenopus laevis	43-55
3736040-5	1986	Pre-injection with tamoxifen or 4-hydroxytamoxifen suppressed the estrogen-dependent induction of vitellogenin in serum.	Tamoxifen	19-28	a1-a	Xenopus laevis	98-110
3736040-5	1986	Pre-injection with tamoxifen or 4-hydroxytamoxifen suppressed the estrogen-dependent induction of vitellogenin in serum.	hydroxytamoxifen	32-50	a1-a	Xenopus laevis	98-110
3736040-6	1986	4-Hydroxytamoxifen also inhibited the induction of intracellular vitellogenin and its mRNA by estrogen suggesting that this metabolite of tamoxifen is able to inhibit estrogen-induced transcription of the vitellogenin genes.	hydroxytamoxifen	0-18	a1-a	Xenopus laevis	65-77
3736040-6	1986	4-Hydroxytamoxifen also inhibited the induction of intracellular vitellogenin and its mRNA by estrogen suggesting that this metabolite of tamoxifen is able to inhibit estrogen-induced transcription of the vitellogenin genes.	hydroxytamoxifen	0-18	a1-a	Xenopus laevis	205-217
3736040-6	1986	4-Hydroxytamoxifen also inhibited the induction of intracellular vitellogenin and its mRNA by estrogen suggesting that this metabolite of tamoxifen is able to inhibit estrogen-induced transcription of the vitellogenin genes.	Tamoxifen	9-18	a1-a	Xenopus laevis	65-77
3736040-6	1986	4-Hydroxytamoxifen also inhibited the induction of intracellular vitellogenin and its mRNA by estrogen suggesting that this metabolite of tamoxifen is able to inhibit estrogen-induced transcription of the vitellogenin genes.	Tamoxifen	9-18	a1-a	Xenopus laevis	205-217
3702426-2	1986	After administration of oestradiol-17 beta there is a dramatic increase in the number of copies of vitellogenin m-RNA in the liver of male oviparous animals, like Xenopus and chicken.	Estradiol	24-42	a1-a	Xenopus laevis	99-111
3944139-2	1986	Vitellogenin transcription was detected 2 h after a single dose of estradiol and reached a maximum on day 4.	Estradiol	67-76	a1-a	Xenopus laevis	0-12
4092682-1	1985	A soluble post-nuclear extract (S-100) specifically switches on the permanently silent vitellogenin genes in male Xenopus liver nuclei in vitro.	s-100	32-37	a1-a	Xenopus laevis	87-99
4092682-3	1985	In the absence of heparin, a liver S-100 extract from female or male Xenopus treated with estradiol, but not from hormonally untreated males, induced the de novo transcription of vitellogenin genes in nuclei from hormonally naive male hepatocytes.	Sulfur	35-36	a1-a	Xenopus laevis	179-191
4092682-3	1985	In the absence of heparin, a liver S-100 extract from female or male Xenopus treated with estradiol, but not from hormonally untreated males, induced the de novo transcription of vitellogenin genes in nuclei from hormonally naive male hepatocytes.	Estradiol	90-99	a1-a	Xenopus laevis	179-191
6510549-5	1984	Naive male cells on primary stimulation with estradiol synthesized vitellogenin mRNA at an average rate of approximately 150 moles/cell/h compared to 1200 moles/cell/h for cells previously exposed to estrogen, thus bearing a close correlation with receptor number.	Estradiol	45-54	a1-a	Xenopus laevis	67-79
6510549-7	1984	Addition of cycloheximide to cell cultures during primary estrogen treatment abolishes both receptor up-regulation and increased rate of vitellogenin gene transcription on secondary stimulation.	Cycloheximide	12-25	a1-a	Xenopus laevis	137-149
6510549-8	1984	In addition, primary treatment with the antiestrogen tamoxifen prevents both receptor up-regulation and an enhanced rate of transcription or accumulation of vitellogenin mRNA on secondary hormonal exposure.	Tamoxifen	53-62	a1-a	Xenopus laevis	157-169
6354735-3	1983	Dexamethasone induced or stimulated the synthesis of many proteins (though limited in number), whereas estradiol induced or stimulated relatively few proteins, including the yolk precursor protein vitellogenin.	Estradiol	103-112	a1-a	Xenopus laevis	197-209
6592586-1	1984	Injection of extracts from Xenopus liver nuclei that are enriched 2000 times in estradiol receptor into Xenopus oocytes induces transcription of the silent vitellogenin locus, which is activated in liver by estradiol, but not of the albumin locus, which is active in liver but suppressed by high levels of estradiol.	Estradiol	80-89	a1-a	Xenopus laevis	156-168
6592586-1	1984	Injection of extracts from Xenopus liver nuclei that are enriched 2000 times in estradiol receptor into Xenopus oocytes induces transcription of the silent vitellogenin locus, which is activated in liver by estradiol, but not of the albumin locus, which is active in liver but suppressed by high levels of estradiol.	Estradiol	207-216	a1-a	Xenopus laevis	156-168
6486424-1	1984	Phosphoprotein kinases from Xenopus and chicken liver have been purified and these enzymes have been used to label Xenopus vitellogenin, a phosphoprotein, to high specific activity with [gamma-32P]ATP.	[gamma-32p	186-196	a1-a	Xenopus laevis	123-135
6486424-1	1984	Phosphoprotein kinases from Xenopus and chicken liver have been purified and these enzymes have been used to label Xenopus vitellogenin, a phosphoprotein, to high specific activity with [gamma-32P]ATP.	Adenosine Triphosphate	197-200	a1-a	Xenopus laevis	123-135
6486424-6	1984	The [32P]vitellogenin labeled in situ was incorporated by oocytes at a rate similar to [32P]vitellogenin labeled in vivo, was translocated to the yolk platelets, and was correctly processed into the yolk proteins.	Phosphorus-32	5-8	a1-a	Xenopus laevis	9-21
6687495-1	1983	In male Xenopus, primary estradiol administration results in noncoordinate activation in the liver of the A and B groups of vitellogenin genes, both as judged by transcription and DNase I sensitivity in isolated nuclei, B group genes being activated preferentially in the first 20 hr.	Estradiol	25-34	a1-a	Xenopus laevis	124-136
6862098-2	1983	Vitellogenin mRNA accumulated for only 12 h after a single addition of 10(-6) M estradiol to male hepatocyte cultures; mestranol, but not 17 alpha-ethinylestradiol or diethylstilbestrol, was more potent than the natural hormone.	Estradiol	80-89	a1-a	Xenopus laevis	0-12
6862098-2	1983	Vitellogenin mRNA accumulated for only 12 h after a single addition of 10(-6) M estradiol to male hepatocyte cultures; mestranol, but not 17 alpha-ethinylestradiol or diethylstilbestrol, was more potent than the natural hormone.	Mestranol	119-128	a1-a	Xenopus laevis	0-12
6862098-3	1983	The level and rate of accumulation of vitellogenin mRNA were 5-15 times higher in female than in male hepatocytes, mestranol and estradiol being more potent than 17 alpha-ethinylestradiol and diethylstilbestrol.	Mestranol	115-124	a1-a	Xenopus laevis	38-50
6862098-3	1983	The level and rate of accumulation of vitellogenin mRNA were 5-15 times higher in female than in male hepatocytes, mestranol and estradiol being more potent than 17 alpha-ethinylestradiol and diethylstilbestrol.	Estradiol	129-138	a1-a	Xenopus laevis	38-50
6862098-3	1983	The level and rate of accumulation of vitellogenin mRNA were 5-15 times higher in female than in male hepatocytes, mestranol and estradiol being more potent than 17 alpha-ethinylestradiol and diethylstilbestrol.	alpha-ethinylestradiol	165-187	a1-a	Xenopus laevis	38-50
6862098-3	1983	The level and rate of accumulation of vitellogenin mRNA were 5-15 times higher in female than in male hepatocytes, mestranol and estradiol being more potent than 17 alpha-ethinylestradiol and diethylstilbestrol.	Diethylstilbestrol	192-210	a1-a	Xenopus laevis	38-50
6862098-6	1983	The addition of fresh estradiol every 4 h to male hepatocyte cultures to compensate for its rapid metabolism resulted in a continuous and sustained accumulation of vitellogenin mRNA at rates comparable to those attained in vivo.	Estradiol	22-31	a1-a	Xenopus laevis	164-176
6687495-4	1983	A non-coordinate activation of the A and B groups of vitellogenin genes is however re-established in response to a second administration of estradiol 8 months after primary stimulation of male Xenopus.	Estradiol	140-149	a1-a	Xenopus laevis	53-65
7162991-3	1982	The relative transcription rate of the vitellogenin genes in estrogen stimulated liver is similar in control and cycloheximide treated animals (800-1000 ppm).	Cycloheximide	113-126	a1-a	Xenopus laevis	39-51
6825700-5	1983	However, hepatocytes from male Xenopus that had received a single injection of estradiol 5 weeks before the cells were prepared, now exhibited identical rates and extent of accumulation of A and B groups of vitellogenin mRNAs to those observed in female cells.	Estradiol	79-88	a1-a	Xenopus laevis	207-219
6641722-1	1983	We have used ammonium sulphate precipitation followed by affinity chromatography to partially purify the estrogen receptor from Xenopus laevis liver which may control the genes for vitellogenin, the precursor of the egg yolk proteins.	Ammonium Sulfate	13-30	a1-a	Xenopus laevis	181-193
6641722-2	1983	The rate at which receptor binds estradiol explains the kinetics of the induction of vitellogenin synthesis by estradiol, and the dissociation constant (0.5 X 10(-9) M) explains the concentration dependence of the response, which has a threshold of 10(-9) M estradiol, when 67% of the receptor is bound to estradiol.	Estradiol	33-42	a1-a	Xenopus laevis	85-97
6641722-2	1983	The rate at which receptor binds estradiol explains the kinetics of the induction of vitellogenin synthesis by estradiol, and the dissociation constant (0.5 X 10(-9) M) explains the concentration dependence of the response, which has a threshold of 10(-9) M estradiol, when 67% of the receptor is bound to estradiol.	Estradiol	111-120	a1-a	Xenopus laevis	85-97
6641722-2	1983	The rate at which receptor binds estradiol explains the kinetics of the induction of vitellogenin synthesis by estradiol, and the dissociation constant (0.5 X 10(-9) M) explains the concentration dependence of the response, which has a threshold of 10(-9) M estradiol, when 67% of the receptor is bound to estradiol.	Estradiol	111-120	a1-a	Xenopus laevis	85-97
6641722-2	1983	The rate at which receptor binds estradiol explains the kinetics of the induction of vitellogenin synthesis by estradiol, and the dissociation constant (0.5 X 10(-9) M) explains the concentration dependence of the response, which has a threshold of 10(-9) M estradiol, when 67% of the receptor is bound to estradiol.	Estradiol	111-120	a1-a	Xenopus laevis	85-97
7162991-6	1982	Since the overall rate of vitellogenin mRNA synthesis is a function of both the selective estrogen activation of vitellogenin gene transcription which is not blocked by cycloheximide and the increased rate of total nuclear RNA synthesis which is blocked by cycloheximide, the total rate of vitellogenin mRNA synthesis is markedly reduced following cycloheximide administration.	Cycloheximide	257-270	a1-a	Xenopus laevis	26-38
7162991-6	1982	Since the overall rate of vitellogenin mRNA synthesis is a function of both the selective estrogen activation of vitellogenin gene transcription which is not blocked by cycloheximide and the increased rate of total nuclear RNA synthesis which is blocked by cycloheximide, the total rate of vitellogenin mRNA synthesis is markedly reduced following cycloheximide administration.	Cycloheximide	257-270	a1-a	Xenopus laevis	26-38
6896404-1	1982	Administration of estradiol 17 beta [estra-1,3,5(10)-triene-3,17-beta-diol] to male Xenopus laevis induces the massive synthesis by the liver of the egg yolk precursor phospholipoglycoprotein, vitellogenin, and its cognate mRNAs.	Estradiol	18-35	a1-a	Xenopus laevis	193-205
6896404-1	1982	Administration of estradiol 17 beta [estra-1,3,5(10)-triene-3,17-beta-diol] to male Xenopus laevis induces the massive synthesis by the liver of the egg yolk precursor phospholipoglycoprotein, vitellogenin, and its cognate mRNAs.	Estradiol	37-74	a1-a	Xenopus laevis	193-205
6126807-0	1982	Effect of calmodulin inhibitor, Stelazine, on the endocytosis of vitellogenin and transglutaminase activity in Xenopus laevis oocytes.	Trifluoperazine	32-41	a1-a	Xenopus laevis	65-77
6126807-1	1982	The specific endocytosis of vitellogenin was measured in the presence of various concentrations of Stelazine, a specific inhibitor of the calcium regulating protein, calmodulin.	Trifluoperazine	99-108	a1-a	Xenopus laevis	28-40
6126807-2	1982	Stelazine (200 microM) was found to inhibit the endocytosis of vitellogenin by 63% as determined by decreased uptake of vitellogenin into transitional yolk bodies and yolk platelets.	Trifluoperazine	0-9	a1-a	Xenopus laevis	63-75
6126807-2	1982	Stelazine (200 microM) was found to inhibit the endocytosis of vitellogenin by 63% as determined by decreased uptake of vitellogenin into transitional yolk bodies and yolk platelets.	Trifluoperazine	0-9	a1-a	Xenopus laevis	120-132
7053388-1	1982	Pulse-chase experiments measuring the rates of incorporation of radiolabeled glucosamine and galactose into intracellular vitellogenin show that glycosylation of this multicomponent protein occurs in a Golgi-enriched fraction isolated from homogenized liver slices.	Glucosamine	77-88	a1-a	Xenopus laevis	122-134
6284130-0	1982	Differential sensitization to deoxyribonuclease I of Xenopus vitellogenin and albumin genes during primary and secondary induction of vitellogenesis by oestradiol.	Estradiol	152-162	a1-a	Xenopus laevis	61-73
7053388-1	1982	Pulse-chase experiments measuring the rates of incorporation of radiolabeled glucosamine and galactose into intracellular vitellogenin show that glycosylation of this multicomponent protein occurs in a Golgi-enriched fraction isolated from homogenized liver slices.	Galactose	93-102	a1-a	Xenopus laevis	122-134
7053388-3	1982	Kinetics of the intracellular translocation of glycosylated vitellogenin indicate that the galactosylated intermediate is secreted more rapidly than the glucosamine-labeled precursor.	Glucosamine	153-164	a1-a	Xenopus laevis	60-72
7053388-5	1982	In addition, a negligible amount of mannose was incorporated into intracellular or secreted vitellogenin.	Mannose	36-43	a1-a	Xenopus laevis	92-104
7053388-6	1982	The antibiotic tunicamycin was shown to inhibit [3H] glucosamine incorporation into microsomal vitellogenin by 70%, without any significant effect on the synthesis of the protein backbone.	Tunicamycin	15-26	a1-a	Xenopus laevis	95-107
7053388-6	1982	The antibiotic tunicamycin was shown to inhibit [3H] glucosamine incorporation into microsomal vitellogenin by 70%, without any significant effect on the synthesis of the protein backbone.	[3h] glucosamine	48-64	a1-a	Xenopus laevis	95-107
7053388-9	1982	In contrast to this finding, gas-liquid chromatography of the alditol acetate derivatives of the neutral hexoses of vitellogenin showed that mannose was indeed a major component of the vitellogenin oligosaccharide side chain.	alditol acetate	62-77	a1-a	Xenopus laevis	116-128
7053388-9	1982	In contrast to this finding, gas-liquid chromatography of the alditol acetate derivatives of the neutral hexoses of vitellogenin showed that mannose was indeed a major component of the vitellogenin oligosaccharide side chain.	Mannose	141-148	a1-a	Xenopus laevis	116-128
7053388-9	1982	In contrast to this finding, gas-liquid chromatography of the alditol acetate derivatives of the neutral hexoses of vitellogenin showed that mannose was indeed a major component of the vitellogenin oligosaccharide side chain.	Mannose	141-148	a1-a	Xenopus laevis	185-197
7053388-9	1982	In contrast to this finding, gas-liquid chromatography of the alditol acetate derivatives of the neutral hexoses of vitellogenin showed that mannose was indeed a major component of the vitellogenin oligosaccharide side chain.	Oligosaccharides	198-213	a1-a	Xenopus laevis	185-197
7053388-10	1982	These preliminary results indicate that the oligosaccharide component of vitellogenin in Xenopus laevis is a "complex" type of carbohydrate unit which is linked via an N-glycosidic bond between an asparagine residue and N-acetylglucosamine.	Oligosaccharides	44-59	a1-a	Xenopus laevis	73-85
7053388-10	1982	These preliminary results indicate that the oligosaccharide component of vitellogenin in Xenopus laevis is a "complex" type of carbohydrate unit which is linked via an N-glycosidic bond between an asparagine residue and N-acetylglucosamine.	Carbohydrates	127-139	a1-a	Xenopus laevis	73-85
7053388-10	1982	These preliminary results indicate that the oligosaccharide component of vitellogenin in Xenopus laevis is a "complex" type of carbohydrate unit which is linked via an N-glycosidic bond between an asparagine residue and N-acetylglucosamine.	Asparagine	197-207	a1-a	Xenopus laevis	73-85
7053388-10	1982	These preliminary results indicate that the oligosaccharide component of vitellogenin in Xenopus laevis is a "complex" type of carbohydrate unit which is linked via an N-glycosidic bond between an asparagine residue and N-acetylglucosamine.	Acetylglucosamine	220-239	a1-a	Xenopus laevis	73-85
7217071-6	1981	The data presented indicate that approximately 70% of the phosphate residues are covalently attached to vitellogenin during its intracellular translocation through the smooth microsomes, while the rough microsomes can account for the remainder of the total incorporated phosphate.	Phosphates	58-67	a1-a	Xenopus laevis	104-116
7217071-6	1981	The data presented indicate that approximately 70% of the phosphate residues are covalently attached to vitellogenin during its intracellular translocation through the smooth microsomes, while the rough microsomes can account for the remainder of the total incorporated phosphate.	Phosphates	270-279	a1-a	Xenopus laevis	104-116
7217071-7	1981	This is further supported by the analysis of newly synthesized and assembled [3H,32P]vitellogenin on sodium dodecyl sulfate-polyacrylamide gels and measurements of protein kinase activity in microsomal subfractions.	Phosphorus-32	81-84	a1-a	Xenopus laevis	85-97
7217071-7	1981	This is further supported by the analysis of newly synthesized and assembled [3H,32P]vitellogenin on sodium dodecyl sulfate-polyacrylamide gels and measurements of protein kinase activity in microsomal subfractions.	Sodium Dodecyl Sulfate	101-123	a1-a	Xenopus laevis	85-97
7217071-7	1981	This is further supported by the analysis of newly synthesized and assembled [3H,32P]vitellogenin on sodium dodecyl sulfate-polyacrylamide gels and measurements of protein kinase activity in microsomal subfractions.	polyacrylamide	124-138	a1-a	Xenopus laevis	85-97
7440543-1	1980	The levels of cytoplasmic and nuclear estrogen receptor have been determined in livers of male Xenopus laevis stimulated by estradiol-17 beta to synthesize vitellogenin mRNA.	Estradiol	124-141	a1-a	Xenopus laevis	156-168
6110664-1	1981	Administration of estradiol-17 beta to male Xenopus laevis evokes the proliferation of the endoplasmic reticulum and the Golgi apparatus and the synthesis and secretion by the liver of massive amounts of the egg yolk precursor phospholipoglycoprotein, vitellogenin.	Estradiol	18-35	a1-a	Xenopus laevis	252-264
7440543-4	1980	Administration of estradiol-17 beta, which induces massive synthesis and accumulation of vitellogenin mRNA, induces the estrogen receptor as well.	Estradiol	18-35	a1-a	Xenopus laevis	89-101
7408885-1	1980	Kinetic analysis of vitellogenin mRNA translation in a cell-free reticulocyte lysate translation system revealed that a serine-rich sequence, most probably containing the phosvitin molecule, is located toward the end of the translational product and therefore resides near to the carboxy terminus of the vitellogenin molecule.	Serine	120-126	a1-a	Xenopus laevis	20-32
7408885-1	1980	Kinetic analysis of vitellogenin mRNA translation in a cell-free reticulocyte lysate translation system revealed that a serine-rich sequence, most probably containing the phosvitin molecule, is located toward the end of the translational product and therefore resides near to the carboxy terminus of the vitellogenin molecule.	Serine	120-126	a1-a	Xenopus laevis	304-316
7408885-2	1980	Translation of the four different vitellogenin mRNAs in vitro and cleavage of the translational products with cyanogen bromide revealed that vitellogenin consists of four different polypeptides, each containing a serine-rich sequence toward its carboxy terminus.	Cyanogen Bromide	110-126	a1-a	Xenopus laevis	141-153
7408885-2	1980	Translation of the four different vitellogenin mRNAs in vitro and cleavage of the translational products with cyanogen bromide revealed that vitellogenin consists of four different polypeptides, each containing a serine-rich sequence toward its carboxy terminus.	Serine	213-219	a1-a	Xenopus laevis	141-153
6772502-0	1980	The role of thyroxine in the transition of vitellogenin synthesis from noninducibility to inducibility during metamorphosis in Xenopus laevis.	Thyroxine	12-21	a1-a	Xenopus laevis	43-55
1270438-0	1976	In vitro translation and estradiol-17beta induction of Xenopus laevis vitellogenin messenger RNA.	Estradiol	25-41	a1-a	Xenopus laevis	70-82
569762-2	1978	One of the Sepharose 4B peaks was shown to contain RNA with a molecular weight reported for vitellogenin mRNA (approximately 34S).	Sepharose	11-20	a1-a	Xenopus laevis	92-104
719747-2	1978	It has a high affinity for estradiol (Kd = 0.5 x 10(-9) M), and the affinities of various steroids for the receptor correlate well with their ability to induce vitellogenin synthesis.	Estradiol	27-36	a1-a	Xenopus laevis	160-172
719747-2	1978	It has a high affinity for estradiol (Kd = 0.5 x 10(-9) M), and the affinities of various steroids for the receptor correlate well with their ability to induce vitellogenin synthesis.	Steroids	90-98	a1-a	Xenopus laevis	160-172
708388-2	1978	Oestradiol-17beta induces livers of Xenopus laevis (South African clawed toad) to synthesize and secrete into the serum large quantities of the egg-yolk-protein precursor, vitellogenin.	Estradiol	0-17	a1-a	Xenopus laevis	172-184
708388-18	1978	analysis of the lipid moiety of secreted vitellogenin showed that up to 35% of its lipid was cholesterol.	Cholesterol	93-104	a1-a	Xenopus laevis	41-53
659432-2	1978	Administration of a secondary injection of estradiol-17 beta to male Xenopus laevis which have been withdrawn from estrogen for 60 days results in synthesis of complete vitellogenin mRNA molecules in as little as 1 h after restimulation.	Estradiol	43-52	a1-a	Xenopus laevis	169-181
659432-2	1978	Administration of a secondary injection of estradiol-17 beta to male Xenopus laevis which have been withdrawn from estrogen for 60 days results in synthesis of complete vitellogenin mRNA molecules in as little as 1 h after restimulation.	17 beta	53-60	a1-a	Xenopus laevis	169-181
658040-1	1978	cDNA synthesized on purified vitellogenin mRNA from Xenopus liver was hybridized to the template in formamide/urea at 22 degrees C to avoid degradation of the RNA.	formamide	100-109	a1-a	Xenopus laevis	29-41
658040-1	1978	cDNA synthesized on purified vitellogenin mRNA from Xenopus liver was hybridized to the template in formamide/urea at 22 degrees C to avoid degradation of the RNA.	Urea	110-114	a1-a	Xenopus laevis	29-41
658040-8	1978	Since the cDNA hybridizing at the internal position could specifically be synthesized on a vitellogenin RNA fragment isolated on poly(U)-Sepharose as an oligo(A)-containing RNA, we conclude that cDNA synthesis is not only initiated by the poly(A) of the 3" end, but also by a specific internal sequence.	poly U-sepharose	129-146	a1-a	Xenopus laevis	91-103
954751-0	1976	Size, complexity and abundance of a specific poly(A)-containing RNA of liver from male Xenopus induced to vitellogenin synthesis by estrogen.	Poly A	45-52	a1-a	Xenopus laevis	106-118
954751-1	1976	Estrogen treatment of Xenopus males leads to the appearance of a new species of poly (A)-containing RNA in the liver, at a stage when large amounts of the estrogen-induced yolk precursor protein, vitellogenin, is produced.	Poly A	80-88	a1-a	Xenopus laevis	196-208
986877-4	1976	In contrast, injected 3H-serine 35S-methionine-labeled Xenopus vitellogenin protein is not converted to yolk platelet proteins and is degraded rather slowly (half-life, 23, 29 hr).	3h-serine	22-31	a1-a	Xenopus laevis	63-75
986877-4	1976	In contrast, injected 3H-serine 35S-methionine-labeled Xenopus vitellogenin protein is not converted to yolk platelet proteins and is degraded rather slowly (half-life, 23, 29 hr).	Sulfur-35	32-35	a1-a	Xenopus laevis	63-75
986877-4	1976	In contrast, injected 3H-serine 35S-methionine-labeled Xenopus vitellogenin protein is not converted to yolk platelet proteins and is degraded rather slowly (half-life, 23, 29 hr).	Methionine	36-46	a1-a	Xenopus laevis	63-75
986877-8	1976	Vitellogenin mRNA sediments at about 29S in a sucrose-SDS gradient, while albumin messenger peaks at 16S; both species contain poly(A).	Sucrose	46-53	a1-a	Xenopus laevis	0-12
986877-8	1976	Vitellogenin mRNA sediments at about 29S in a sucrose-SDS gradient, while albumin messenger peaks at 16S; both species contain poly(A).	Sodium Dodecyl Sulfate	54-57	a1-a	Xenopus laevis	0-12
7357606-2	1980	In this paper we describe large nuclear RNAs containing vitellogenin mRNA sequences as revealed by hybridization of cloned vitellogenin cDNAs to nuclear RNA separated on agarose gels.	Sepharose	170-177	a1-a	Xenopus laevis	56-68
7357606-3	1980	Putative vitellogenin mRNA precursors, which are recovered as poly(A)-containing RNA, have been identified for the four known vitellogenin mRNAs.	Poly A	62-69	a1-a	Xenopus laevis	9-21
488117-1	1979	Purified vitellogenin mRNA of Xenopus laevis was incubated with mechanically sheared DNA in high concentrations of formamide and the resulting R-loops (i.e. RNA .	formamide	115-124	a1-a	Xenopus laevis	9-21
488117-3	1979	Hybridization with 125I-labeled vitellogenin mRNA revealed a 15--30-fold enrichment of the DNA coding for vitellogenin.	Iodine-125	19-23	a1-a	Xenopus laevis	32-44
488117-3	1979	Hybridization with 125I-labeled vitellogenin mRNA revealed a 15--30-fold enrichment of the DNA coding for vitellogenin.	Iodine-125	19-23	a1-a	Xenopus laevis	106-118
383554-0	1979	Parenchymal cells purified from Xenopus liver and maintained in primary culture synthesize vitellogenin in response to estradiol-17 beta and serum albumin in response to dexamethasone.	Estradiol	119-136	a1-a	Xenopus laevis	91-103
383554-0	1979	Parenchymal cells purified from Xenopus liver and maintained in primary culture synthesize vitellogenin in response to estradiol-17 beta and serum albumin in response to dexamethasone.	Dexamethasone	170-183	a1-a	Xenopus laevis	91-103
729959-1	1978	Oestradiol induces vitellogenin synthesis in vitro in liver taken from Xenopus laevis tadpoles that are in late metamorphosis.	Estradiol	0-10	a1-a	Xenopus laevis	19-31
729904-0	1978	Estradiol-induced accumulation of vitellogenin mRNA and secretion of vitellogenin in liver cultures of Xenopus.	Estradiol	0-9	a1-a	Xenopus laevis	34-46
729904-0	1978	Estradiol-induced accumulation of vitellogenin mRNA and secretion of vitellogenin in liver cultures of Xenopus.	Estradiol	0-9	a1-a	Xenopus laevis	69-81
729904-1	1978	Explants of male Xenopus liver maintained in a serum-free culture medium respond to stimulation by 2 X 10(-8) M 17beta-estradiol with an increasing rate of accumulation of vitellogenin mRNA, as revealed by hybridization of cDNA to the total cytoplasmic RNA extracted from the cultures.	Estradiol	112-128	a1-a	Xenopus laevis	172-184
729904-2	1978	A similar response is observed for secretion of 32PO4-labeled vitellogenin into the culture medium.	32po4	48-53	a1-a	Xenopus laevis	62-74
729904-4	1978	Since essential features of the in vivo response are maintained in liver explants, organ culture appears suitable for investigating initial events of estradiol action leading to enhanced synthesis of vitellogenin.	Estradiol	150-159	a1-a	Xenopus laevis	200-212
849274-17	1977	These precursor data fit in well with structural studies on serum vitellogenin, since it has been shown that the latter protein consists of two identical subunits each with a mobility on sodium dodecyl sulphate/polyacrylamide gels identical with that shown by the microsomal precursor.	Sodium Dodecyl Sulfate	187-210	a1-a	Xenopus laevis	66-78
849274-17	1977	These precursor data fit in well with structural studies on serum vitellogenin, since it has been shown that the latter protein consists of two identical subunits each with a mobility on sodium dodecyl sulphate/polyacrylamide gels identical with that shown by the microsomal precursor.	polyacrylamide	211-225	a1-a	Xenopus laevis	66-78
849274-20	1977	It was also shown that trypsin or chymotrypsin can cleave the serum vitellogenin into leucine- and serine-rich fragments which resemble lipovitellin and phosvitin respectively.	Leucine	86-93	a1-a	Xenopus laevis	68-80
849274-20	1977	It was also shown that trypsin or chymotrypsin can cleave the serum vitellogenin into leucine- and serine-rich fragments which resemble lipovitellin and phosvitin respectively.	Serine	99-105	a1-a	Xenopus laevis	68-80
1270438-1	1976	Administration of estradiol-17beta to male Xenopus laevis induces synthesis and secretion by the liver of the egg yolk precursor protein vitellogenin.	Estradiol	18-34	a1-a	Xenopus laevis	137-149
1270438-2	1976	RNA extracted from livers of estradiol-17beta-treated Xenopus laevis directs the synthesis of the entire 200,000-dalton vitellogenin monomer in a cell-free protein synthesizing system derived from rabbit reticulocytes.	Estradiol	29-38	a1-a	Xenopus laevis	120-132
1270438-2	1976	RNA extracted from livers of estradiol-17beta-treated Xenopus laevis directs the synthesis of the entire 200,000-dalton vitellogenin monomer in a cell-free protein synthesizing system derived from rabbit reticulocytes.	17beta	39-45	a1-a	Xenopus laevis	120-132
1270438-3	1976	Vitellogenin synthesized in vitro was isolated and quantitated by indirect immunoprecipitation and identified by comparison to authentic [14C]vitellogenin.	Carbon-14	138-141	a1-a	Xenopus laevis	0-12
1270438-4	1976	The in vitro product and [14C]vitellogenin co-migrate on electrophoresis in sodium dodecyl sulfate-polyacrylamide gels and they exhibit identical immunoprecipitation curves.	Carbon-14	26-29	a1-a	Xenopus laevis	30-42
1270438-4	1976	The in vitro product and [14C]vitellogenin co-migrate on electrophoresis in sodium dodecyl sulfate-polyacrylamide gels and they exhibit identical immunoprecipitation curves.	Sodium Dodecyl Sulfate	76-98	a1-a	Xenopus laevis	30-42
1270438-4	1976	The in vitro product and [14C]vitellogenin co-migrate on electrophoresis in sodium dodecyl sulfate-polyacrylamide gels and they exhibit identical immunoprecipitation curves.	polyacrylamide	99-113	a1-a	Xenopus laevis	30-42
1270438-5	1976	Xenopus laevis vitellogenin messenger RNA has a sedimentation coefficient of approximately 30 S in sucrose density gradients.	Sucrose	99-106	a1-a	Xenopus laevis	15-27
1270438-9	1976	Vitellogenin synthesis is maximal 12 days after estradiol-17beta administration when it comprises approximately 70% of cell protein synthesis.	Estradiol	48-64	a1-a	Xenopus laevis	0-12
1270438-10	1976	The level of vitellogenin mRNA and the intracellular rate of vitellogenin synthesis exhibit a close correspondence from 4 to 16 days after administration of estradiol-17beta.	Estradiol	157-173	a1-a	Xenopus laevis	13-25
1270438-10	1976	The level of vitellogenin mRNA and the intracellular rate of vitellogenin synthesis exhibit a close correspondence from 4 to 16 days after administration of estradiol-17beta.	Estradiol	157-173	a1-a	Xenopus laevis	61-73
1248478-5	1976	Vitellogenin synthesis was induced in male Xenopus liver by oestradiol treatment.	Estradiol	60-70	a1-a	Xenopus laevis	0-12
1248478-10	1976	RNA extracted from livers of oestradiol-treated male Xenopus and from purified polysomes is shown to code for the synthesis of vitellogenin-specific immunoprecipitable polypeptides in a rabbit reticulocyte cell-free protein-synthesizing system, a major component having a molecular weight of 210000.	Estradiol	29-39	a1-a	Xenopus laevis	127-139
949740-0	1976	Direct induction by estradiol on vitellogenin synthesis in organ cultures of male Xenopus laevis liver.	Estradiol	20-29	a1-a	Xenopus laevis	33-45
949740-1	1976	Organ cultures of liver from untreated male Xenopus respond to 17 beta-estradiol in the culture medium by synthesizing and secreting the yolk protein precursor vitellogenin.	Estradiol	63-80	a1-a	Xenopus laevis	160-172
1020011-0	1976	Investigation of the mechanisms and consequences of steroid hormone action on vitellogenin synthesis in Xenopus laevis.	Steroids	52-67	a1-a	Xenopus laevis	78-90
1059103-0	1975	Synthesis of vitellogenin in cultures of male and female frog liver regulated by estradiol treatment in vitro.	Estradiol	81-90	a1-a	Xenopus laevis	13-25
1059103-1	1975	Using the frog Xenopus laevis, we show that the addition of physiological concentrations of estradiol to cultures of liver from untreated males rapidly induces the synthesis of large amounts of vitellogenin.	Estradiol	92-101	a1-a	Xenopus laevis	194-206
1059103-2	1975	Sustained synthesis of vitellogenin requires continuous exposure to estradiol.	Estradiol	68-77	a1-a	Xenopus laevis	23-35
5131730-4	1971	The incorporation of l-[4,5-(3)H]-leucine into vitellogenin in vivo and in vitro was observed 12-24h after hormone treatment and increased progressively up to 21 days after treatment.	l-[4,5-(3)h]-leucine	21-41	a1-a	Xenopus laevis	47-59
1117004-1	1975	Administration of a single injection of estradiol-17 beta to adult male Xenopus laevis induces the synthesis and secretion by the liver of the egg-yolk protein complex vitellogenin.	Estradiol	40-57	a1-a	Xenopus laevis	168-180
1117004-10	1975	The major component of vitellogenin labeled wither in vivo or in culture has a molecular weight of approximately 180,000 as shown by sodium dodecyl sulfate polyacrylamide gel electrophoresis.	Sodium Dodecyl Sulfate	133-155	a1-a	Xenopus laevis	23-35
1117004-10	1975	The major component of vitellogenin labeled wither in vivo or in culture has a molecular weight of approximately 180,000 as shown by sodium dodecyl sulfate polyacrylamide gel electrophoresis.	polyacrylamide	156-170	a1-a	Xenopus laevis	23-35
4544841-8	1974	These results demonstrate the macromolecular vitellogenin transport system remains operative in oocytes which can undergo nuclear maturation and that the steroid DOCA can affect its function.	Steroids	154-161	a1-a	Xenopus laevis	45-57
4544841-8	1974	These results demonstrate the macromolecular vitellogenin transport system remains operative in oocytes which can undergo nuclear maturation and that the steroid DOCA can affect its function.	Desoxycorticosterone Acetate	162-166	a1-a	Xenopus laevis	45-57
4544841-4	1974	Oocytes simultaneously exposed to DOCA and to labeled vitellogenin exhibited both inhibition of vitellogenin incorporation and stimulation of nuclear maturation and cortical changes.	Desoxycorticosterone Acetate	34-38	a1-a	Xenopus laevis	96-108
4544841-6	1974	Preincubation of oocytes in steroid for 9 h essentially terminated vitellogenin incorporation.	Steroids	28-35	a1-a	Xenopus laevis	67-79
4544841-7	1974	Incorporation of vitellogenin occurred after removal of follicle cells from the oocyte by a short treatment with EDTA.	Edetic Acid	113-117	a1-a	Xenopus laevis	17-29
4724585-3	1973	Incorporation of [(32)P]P(i) and [(3)H]leucine into vitellogenin secreted in vitro by liver slices from oestrogen-treated Xenopus laevis is accompanied by a 2h lag; no lag is apparent for the incorporation into total tissue protein.	[(32)p]p	17-25	a1-a	Xenopus laevis	52-64
4724585-3	1973	Incorporation of [(32)P]P(i) and [(3)H]leucine into vitellogenin secreted in vitro by liver slices from oestrogen-treated Xenopus laevis is accompanied by a 2h lag; no lag is apparent for the incorporation into total tissue protein.	[(3)h]leucine	33-46	a1-a	Xenopus laevis	52-64
4724585-3	1973	Incorporation of [(32)P]P(i) and [(3)H]leucine into vitellogenin secreted in vitro by liver slices from oestrogen-treated Xenopus laevis is accompanied by a 2h lag; no lag is apparent for the incorporation into total tissue protein.	Deuterium	157-159	a1-a	Xenopus laevis	52-64
4724585-6	1973	The incorporation into secreted vitellogenin, however, continued for 2h after the addition of cycloheximide.	Cycloheximide	94-107	a1-a	Xenopus laevis	32-44
4724585-8	1973	Pulse-labelling of liver slices with [(3)H]leucine for 30min, followed by a chase with a large excess of unlabelled leucine, resulted in the appearance of radioactivity in secreted vitellogenin from 90min after the end of the pulse period.	[(3)h]leucine	37-50	a1-a	Xenopus laevis	181-193
4724585-8	1973	Pulse-labelling of liver slices with [(3)H]leucine for 30min, followed by a chase with a large excess of unlabelled leucine, resulted in the appearance of radioactivity in secreted vitellogenin from 90min after the end of the pulse period.	Leucine	43-50	a1-a	Xenopus laevis	181-193
4724585-12	1973	The incorporation of [(32)P]P(i) into vitellogenin followed a pattern identical with that found for [(3)H]leucine in the pulse-labelling experiments and this indicates that synthesis of the polypeptide chain and incorporation of P(i) are closely linked processes.	Phosphorus-32	21-27	a1-a	Xenopus laevis	38-50
4724585-12	1973	The incorporation of [(32)P]P(i) into vitellogenin followed a pattern identical with that found for [(3)H]leucine in the pulse-labelling experiments and this indicates that synthesis of the polypeptide chain and incorporation of P(i) are closely linked processes.	Phosphorus	26-27	a1-a	Xenopus laevis	38-50
5131730-8	1971	The biosynthesis in vitro of vitellogenin was inhibited by cycloheximide and carbonyl cyanide m-chlorophenylhydrazone, stimulated by increased Ca(2+) concentrations and decreased by raising the incubation temperature from 22 to 37 degrees C. 5.	Cycloheximide	59-72	a1-a	Xenopus laevis	29-41
5131730-8	1971	The biosynthesis in vitro of vitellogenin was inhibited by cycloheximide and carbonyl cyanide m-chlorophenylhydrazone, stimulated by increased Ca(2+) concentrations and decreased by raising the incubation temperature from 22 to 37 degrees C. 5.	Carbonyl Cyanide m-Chlorophenyl Hydrazone	77-117	a1-a	Xenopus laevis	29-41
5131731-1	1971	A single lipophosphoprotein complex, vitellogenin, was isolated and purified from the plasma of oestrogen-stimulated female toads by preparative ultracentrifugation and chromatography on TEAE-cellulose (triethylaminoethylcellulose).	Cellulose	192-201	a1-a	Xenopus laevis	37-49
5131731-1	1971	A single lipophosphoprotein complex, vitellogenin, was isolated and purified from the plasma of oestrogen-stimulated female toads by preparative ultracentrifugation and chromatography on TEAE-cellulose (triethylaminoethylcellulose).	triethylaminoethyl cellulose	203-230	a1-a	Xenopus laevis	37-49
16141552-0	2005	Effects of nonylphenol and triclosan on production of plasma vitellogenin and testosterone in male South African clawed frogs (Xenopus laevis).	nonylphenol	11-22	a1-a	Xenopus laevis	61-73
5124778-3	1971	Vitellogenin was purified from serum by dimethylformamide precipitation and was shown to be homogeneous by a variety of electrophoretic techniques.	Dimethylformamide	40-57	a1-a	Xenopus laevis	0-12
5124778-11	1971	The carbohydrate moiety consisted of 0.4g of hexose, 0.77g of hexosamine and 0.18g of sialic acid/100g of vitellogenin.	Carbohydrates	4-16	a1-a	Xenopus laevis	106-118
5124778-11	1971	The carbohydrate moiety consisted of 0.4g of hexose, 0.77g of hexosamine and 0.18g of sialic acid/100g of vitellogenin.	N-Acetylneuraminic Acid	86-97	a1-a	Xenopus laevis	106-118
5124778-13	1971	The calcium and phosphorus contents were 0.85 and 1.65g/100g of vitellogenin respectively.	Calcium	4-11	a1-a	Xenopus laevis	64-76
5124778-13	1971	The calcium and phosphorus contents were 0.85 and 1.65g/100g of vitellogenin respectively.	Phosphorus	16-26	a1-a	Xenopus laevis	64-76
5124778-17	1971	Of this activity 65.4% was associated with the vitellogenin band on cellulose acetate electrophoresis.	acetylcellulose	68-85	a1-a	Xenopus laevis	47-59
22692001-9	2012	The production of vitellogenin was probably temporally separated and independent from primary effects on sexual differentiation, and might have contributed to delays in metamorphosis observed in individuals exposed to EE2.	Ethinyl Estradiol	218-221	a1-a	Xenopus laevis	18-30
21308852-4	2011	Here, we show that dimple glycoproteins and a protein represented by a 120-kDa band released following gel-into-gel SDS-PAGE of both glycoproteins share the same N-terminal amino acid sequence, which itself is similar to the N-termini of Xenopus liver-synthesized vitellogenin (VTG) and the lipovitellin 1.	Sodium Dodecyl Sulfate	116-119	a1-a	Xenopus laevis	264-276
21308852-4	2011	Here, we show that dimple glycoproteins and a protein represented by a 120-kDa band released following gel-into-gel SDS-PAGE of both glycoproteins share the same N-terminal amino acid sequence, which itself is similar to the N-termini of Xenopus liver-synthesized vitellogenin (VTG) and the lipovitellin 1.	Sodium Dodecyl Sulfate	116-119	a1-a	Xenopus laevis	278-281
16899342-7	2007	This translates into a polyglutamine (polyQ) tract of prolonged length in the carboxyl terminal of the alpha1A subunit.	polyglutamine	23-36	a1-a	Xenopus laevis	103-110
16899342-7	2007	This translates into a polyglutamine (polyQ) tract of prolonged length in the carboxyl terminal of the alpha1A subunit.	polyglutamine	38-43	a1-a	Xenopus laevis	103-110
16306128-5	2006	Upon coexpressing the cRNA of alpha(1A)-WT with each alpha(1A)-mutant in molar ratios ranging from 1:1 to 1:10, the amplitude of Ba(2+) currents through wild-type (WT)-Cav2.1 channels decreased significantly as the relative molar ratio of alpha(1A)-mutants increased, suggesting the presence of an alpha(1A)-mutant-specific suppression effect.	Barium	129-131	a1-a	Xenopus laevis	30-38
16306128-5	2006	Upon coexpressing the cRNA of alpha(1A)-WT with each alpha(1A)-mutant in molar ratios ranging from 1:1 to 1:10, the amplitude of Ba(2+) currents through wild-type (WT)-Cav2.1 channels decreased significantly as the relative molar ratio of alpha(1A)-mutants increased, suggesting the presence of an alpha(1A)-mutant-specific suppression effect.	Barium	129-131	a1-a	Xenopus laevis	53-61
16306128-5	2006	Upon coexpressing the cRNA of alpha(1A)-WT with each alpha(1A)-mutant in molar ratios ranging from 1:1 to 1:10, the amplitude of Ba(2+) currents through wild-type (WT)-Cav2.1 channels decreased significantly as the relative molar ratio of alpha(1A)-mutants increased, suggesting the presence of an alpha(1A)-mutant-specific suppression effect.	Barium	129-131	a1-a	Xenopus laevis	53-61
16306128-5	2006	Upon coexpressing the cRNA of alpha(1A)-WT with each alpha(1A)-mutant in molar ratios ranging from 1:1 to 1:10, the amplitude of Ba(2+) currents through wild-type (WT)-Cav2.1 channels decreased significantly as the relative molar ratio of alpha(1A)-mutants increased, suggesting the presence of an alpha(1A)-mutant-specific suppression effect.	Barium	129-131	a1-a	Xenopus laevis	53-61
25819740-4	2015	The results of this study demonstrate for the first time that beside an increase of the hepatic vitellogenin gene expression, exposure to EE2 also decreases the gene expression of the hepatic heme oxygenase 1 and 2 (HO1, HO2), degrading heme of different heme proteins to biliverdin, as well as of the biliverdin reductase A (BLVRA), which converts biliverdin to bilirubin.	Ethinyl Estradiol	138-141	a1-a	Xenopus laevis	96-108
20060147-0	2010	Hydroxylated polychlorinated biphenyls (OH-PCBs) induce vitellogenin through estrogenic activity in primary-cultured hepatocytes of the Xenopus laevis.	Polychlorinated Biphenyls	13-38	a1-a	Xenopus laevis	56-68
20060147-0	2010	Hydroxylated polychlorinated biphenyls (OH-PCBs) induce vitellogenin through estrogenic activity in primary-cultured hepatocytes of the Xenopus laevis.	oh-pcbs	40-47	a1-a	Xenopus laevis	56-68
20060147-1	2010	Vitellogenin (VTG)-inducing activities of 21 kinds of hydroxylated polychlorinated biphenyls (OH-PCBs) were investigated by an assay system using the primary-cultured hepatocyte of the adult male Xenopus laevis.	Polychlorinated Biphenyls	67-92	a1-a	Xenopus laevis	0-12
20060147-1	2010	Vitellogenin (VTG)-inducing activities of 21 kinds of hydroxylated polychlorinated biphenyls (OH-PCBs) were investigated by an assay system using the primary-cultured hepatocyte of the adult male Xenopus laevis.	Polychlorinated Biphenyls	67-92	a1-a	Xenopus laevis	14-17
20060147-1	2010	Vitellogenin (VTG)-inducing activities of 21 kinds of hydroxylated polychlorinated biphenyls (OH-PCBs) were investigated by an assay system using the primary-cultured hepatocyte of the adult male Xenopus laevis.	oh-pcbs	94-101	a1-a	Xenopus laevis	0-12
20060147-1	2010	Vitellogenin (VTG)-inducing activities of 21 kinds of hydroxylated polychlorinated biphenyls (OH-PCBs) were investigated by an assay system using the primary-cultured hepatocyte of the adult male Xenopus laevis.	oh-pcbs	94-101	a1-a	Xenopus laevis	14-17
20060147-3	2010	The levels of VTG production in hepatocytes of male X. laevis exposed to six kinds of OH-PCB isomers (2"-OH-CB30, 3"-OH-CB30, 4"-OH-CB30, 4"-OH-CB50, 4"-OH-CB61 4"-OH-CB65) were significantly higher as compared to the control group (p<0.05).	oh-pcb	86-92	a1-a	Xenopus laevis	14-17
20060147-6	2010	The results from VTG-assays suggested that an important factor for determining estrogenicity is the positions of the hydroxyl group and chlorine with the highest activity resulting from a para-hydroxyl group.	Chlorine	136-144	a1-a	Xenopus laevis	17-20
20060147-7	2010	The OH-PCB structures of high rank order in the VTG-assay had no chlorine substituted phenolic ring.	oh-pcb	4-10	a1-a	Xenopus laevis	48-51
17076324-0	2006	Estrogenic activity of phthalate esters by in vitro VTG assay using primary-cultured Xenopus hepatocytes.	phthalate esters	23-39	a1-a	Xenopus laevis	52-55
16141552-0	2005	Effects of nonylphenol and triclosan on production of plasma vitellogenin and testosterone in male South African clawed frogs (Xenopus laevis).	Triclosan	27-36	a1-a	Xenopus laevis	61-73
16141552-1	2005	We investigated the effects of nonylphenol (NP) and triclosan (TCS) on production of vitellogenin (Vg), testosterone (T), and hepatic cytochrome P450 1A and 2B activities in male South African clawed frogs (Xenopus laevis).	nonylphenol	44-46	a1-a	Xenopus laevis	85-97
16141552-1	2005	We investigated the effects of nonylphenol (NP) and triclosan (TCS) on production of vitellogenin (Vg), testosterone (T), and hepatic cytochrome P450 1A and 2B activities in male South African clawed frogs (Xenopus laevis).	Triclosan	63-66	a1-a	Xenopus laevis	85-97
16141552-4	2005	However, the levels of plasma Vg in all TCS treatment groups (intraperitoneal injection of 4, 40, and 400 microg/g body weight) were lower than that in the solvent control group, and male frogs injected with high doses of NP or TCS had lower T levels than the control group.	Triclosan	40-43	a1-a	Xenopus laevis	30-32
16141552-6	2005	Male frogs injected with 20 microg/g body weight of estradiol-17beta had significantly higher plasma Vg levels than the control group.	Estradiol	52-68	a1-a	Xenopus laevis	101-103
12520397-12	2003	Results also confirm the ability of 17beta-estradiol to stimulate production and release of VTG in the liver of male X. laevis, although we could not confirm the in vivo induction of VTG by estrogenic mimics octylphenol and nonylphenol.	Estradiol	36-52	a1-a	Xenopus laevis	92-95
12944396-6	2003	In pull-down experiments, the xARH phosphotyrosine binding domain interacted with the LDL and vitellogenin receptors found in Xenopus oocytes and embryos.	xarh	30-34	a1-a	Xenopus laevis	94-106
12944396-6	2003	In pull-down experiments, the xARH phosphotyrosine binding domain interacted with the LDL and vitellogenin receptors found in Xenopus oocytes and embryos.	Phosphotyrosine	35-50	a1-a	Xenopus laevis	94-106
12520397-12	2003	Results also confirm the ability of 17beta-estradiol to stimulate production and release of VTG in the liver of male X. laevis, although we could not confirm the in vivo induction of VTG by estrogenic mimics octylphenol and nonylphenol.	nonylphenol	224-235	a1-a	Xenopus laevis	92-95
12146976-7	2002	In these organelles, biliverdin is associated entirely with the lipovitellin domain of the processed vitellogenin.	Biliverdine	21-31	a1-a	Xenopus laevis	101-113
10028703-11	1999	In addition, butylhydroxyanisol and octylphenol, both showed feminization at 10(-7) M while octylphenol was also effective at 10(-8) M. In summary these results demonstrate for the first time the use of a semiquantitative RT-PCR technique for screening estrogenicity by assaying mRNA induction of the estrogenic biomarker vitellogenin in vitro.	octylphenol	36-47	a1-a	Xenopus laevis	322-334
10964945-2	2000	The underlying mutation in SCA6 consists of an expansion of a trinucleotide CAG repeat in the 3" region of the gene, CACNA1A, encoding the alpha(1A) subunit of the neuronal P/Q-type voltage-gated calcium channel.	trinucleotide	62-75	a1-a	Xenopus laevis	139-147
10964945-2	2000	The underlying mutation in SCA6 consists of an expansion of a trinucleotide CAG repeat in the 3" region of the gene, CACNA1A, encoding the alpha(1A) subunit of the neuronal P/Q-type voltage-gated calcium channel.	Calcium	196-203	a1-a	Xenopus laevis	139-147
10964945-3	2000	Although it is known that this mutation results in an expanded tract of glutamine residues in some alpha(1A) splice forms, the distribution of these splice forms and the role of this mutation in the highly selective Purkinje cell degeneration seen in SCA6 have yet to be elucidated.	Glutamine	72-81	a1-a	Xenopus laevis	99-107
10964945-5	2000	Using alpha(1A) subunit chimeras expressing SCA6 mutations, we show that the SCA6 polyglutamine expansion shifts the voltage dependence of channel activation and rate of inactivation only when expressed with beta(4) subunits and impairs normal G-protein regulation of P/Q channels.	polyglutamine	82-95	a1-a	Xenopus laevis	6-14
10028703-11	1999	In addition, butylhydroxyanisol and octylphenol, both showed feminization at 10(-7) M while octylphenol was also effective at 10(-8) M. In summary these results demonstrate for the first time the use of a semiquantitative RT-PCR technique for screening estrogenicity by assaying mRNA induction of the estrogenic biomarker vitellogenin in vitro.	octylphenol	92-103	a1-a	Xenopus laevis	322-334
8845382-1	1995	Xenopus laevis vitellogenin contains 2 g-atoms (g-at) of Zn and 3 g-at of Ca/dimer, transports zinc in plasma, and plays a role in its distribution within the oocyte [Montorzi et al.	Zinc	57-59	a1-a	Xenopus laevis	15-27
8845382-8	1995	We here report the dynamics and time course of Zn65-labeled vitellogenin uptake by and distribution within stages II and IV oocytes, the fate of the metal in oocytes as they progress from stages II to VI, as well as in the first two cleavage blastomeres, the blastula, and subsequent stages of the developing embryo and tadpole.	zn65	47-51	a1-a	Xenopus laevis	60-72
8845382-9	1995	Zn65 bound to vitellogenin is taken up within less than 30 min by either stage II or IV oocytes incubated under in vitro culture conditions whereas free Zn65 is not.	zn65	0-4	a1-a	Xenopus laevis	14-26
8845382-9	1995	Zn65 bound to vitellogenin is taken up within less than 30 min by either stage II or IV oocytes incubated under in vitro culture conditions whereas free Zn65 is not.	zn65	153-157	a1-a	Xenopus laevis	14-26
7662665-1	1995	Xenopus laevis vitellogenin is a plasma protein that contains a total of 5 mol of metal/440 kDa dimer, 2 mol of zinc, and 3 mol of calcium (Montorzi et al.	Metals	82-87	a1-a	Xenopus laevis	15-27
7662665-1	1995	Xenopus laevis vitellogenin is a plasma protein that contains a total of 5 mol of metal/440 kDa dimer, 2 mol of zinc, and 3 mol of calcium (Montorzi et al.	Calcium	131-138	a1-a	Xenopus laevis	15-27
7662665-10	1995	We here show by metal analysis of the individual proteins generated by vitellogenin processing that zinc and calcium occur in different domains of the vitellogenin polypeptide chain.	Metals	16-21	a1-a	Xenopus laevis	71-83
7662665-10	1995	We here show by metal analysis of the individual proteins generated by vitellogenin processing that zinc and calcium occur in different domains of the vitellogenin polypeptide chain.	Metals	16-21	a1-a	Xenopus laevis	151-163
7662665-10	1995	We here show by metal analysis of the individual proteins generated by vitellogenin processing that zinc and calcium occur in different domains of the vitellogenin polypeptide chain.	Calcium	109-116	a1-a	Xenopus laevis	71-83
7662665-10	1995	We here show by metal analysis of the individual proteins generated by vitellogenin processing that zinc and calcium occur in different domains of the vitellogenin polypeptide chain.	Calcium	109-116	a1-a	Xenopus laevis	151-163
7662665-12	1995	Calcium, in contrast, is detected exclusively in phosvitin which, in addition, contains 3 mol of magnesium/35 kDa, apparently acquired following vitellogenin entry into the oocyte.	Calcium	0-7	a1-a	Xenopus laevis	145-157
7779754-1	1995	17 beta-estradiol induces the synthesis of massive amounts of the hepatic mRNA encoding the Xenopus laevis egg yolk precursor protein, vitellogenin.	Estradiol	3-17	a1-a	Xenopus laevis	135-147
7779754-4	1995	We recently reported that Xenopus liver contains a protein, which is induced by 17 beta-estradiol and binds with a high degree of specificity to a binding site in a segment of the 3"-untranslated region (3"-UTR) of vitellogenin mRNA implicated in 17 beta-estradiol stabilization of vitellogenin mRNA.	Estradiol	80-97	a1-a	Xenopus laevis	215-227
7779754-4	1995	We recently reported that Xenopus liver contains a protein, which is induced by 17 beta-estradiol and binds with a high degree of specificity to a binding site in a segment of the 3"-untranslated region (3"-UTR) of vitellogenin mRNA implicated in 17 beta-estradiol stabilization of vitellogenin mRNA.	Estradiol	80-97	a1-a	Xenopus laevis	282-294
7779754-4	1995	We recently reported that Xenopus liver contains a protein, which is induced by 17 beta-estradiol and binds with a high degree of specificity to a binding site in a segment of the 3"-untranslated region (3"-UTR) of vitellogenin mRNA implicated in 17 beta-estradiol stabilization of vitellogenin mRNA.	Estradiol	247-264	a1-a	Xenopus laevis	215-227
7779754-4	1995	We recently reported that Xenopus liver contains a protein, which is induced by 17 beta-estradiol and binds with a high degree of specificity to a binding site in a segment of the 3"-untranslated region (3"-UTR) of vitellogenin mRNA implicated in 17 beta-estradiol stabilization of vitellogenin mRNA.	Estradiol	247-264	a1-a	Xenopus laevis	282-294
7779754-8	1995	Testosterone administration induced the vitellogenin 3"-UTR RNA binding protein in several tissues.	Testosterone	0-12	a1-a	Xenopus laevis	40-52
7821717-1	1994	Earlier studies from our laboratory had shown that triiodothyronine (T3) strongly potentiates the activation by estradiol (E2) of silent vitellogenin (Vit) genes and the autoinduction of estrogen receptor (ER) mRNA in primary cultures of male Xenopus hepatocytes (Rabelo and Tata, 1993).	Triiodothyronine	51-67	a1-a	Xenopus laevis	137-149
7556019-8	1995	In both species, estradiol and DES treatments induced the most vitellogenin, whereas DDT treatments induced smaller amounts of vitellogenin in a dose-dependent fashion.	Estradiol	17-26	a1-a	Xenopus laevis	63-75
7556019-8	1995	In both species, estradiol and DES treatments induced the most vitellogenin, whereas DDT treatments induced smaller amounts of vitellogenin in a dose-dependent fashion.	Diethylstilbestrol	31-34	a1-a	Xenopus laevis	63-75
7556019-8	1995	In both species, estradiol and DES treatments induced the most vitellogenin, whereas DDT treatments induced smaller amounts of vitellogenin in a dose-dependent fashion.	DDT	85-88	a1-a	Xenopus laevis	127-139
7821717-1	1994	Earlier studies from our laboratory had shown that triiodothyronine (T3) strongly potentiates the activation by estradiol (E2) of silent vitellogenin (Vit) genes and the autoinduction of estrogen receptor (ER) mRNA in primary cultures of male Xenopus hepatocytes (Rabelo and Tata, 1993).	Triiodothyronine	51-67	a1-a	Xenopus laevis	151-154
7821717-1	1994	Earlier studies from our laboratory had shown that triiodothyronine (T3) strongly potentiates the activation by estradiol (E2) of silent vitellogenin (Vit) genes and the autoinduction of estrogen receptor (ER) mRNA in primary cultures of male Xenopus hepatocytes (Rabelo and Tata, 1993).	Triiodothyronine	69-71	a1-a	Xenopus laevis	137-149
7821717-1	1994	Earlier studies from our laboratory had shown that triiodothyronine (T3) strongly potentiates the activation by estradiol (E2) of silent vitellogenin (Vit) genes and the autoinduction of estrogen receptor (ER) mRNA in primary cultures of male Xenopus hepatocytes (Rabelo and Tata, 1993).	Triiodothyronine	69-71	a1-a	Xenopus laevis	151-154
7821717-1	1994	Earlier studies from our laboratory had shown that triiodothyronine (T3) strongly potentiates the activation by estradiol (E2) of silent vitellogenin (Vit) genes and the autoinduction of estrogen receptor (ER) mRNA in primary cultures of male Xenopus hepatocytes (Rabelo and Tata, 1993).	Estradiol	112-121	a1-a	Xenopus laevis	137-149
7821717-1	1994	Earlier studies from our laboratory had shown that triiodothyronine (T3) strongly potentiates the activation by estradiol (E2) of silent vitellogenin (Vit) genes and the autoinduction of estrogen receptor (ER) mRNA in primary cultures of male Xenopus hepatocytes (Rabelo and Tata, 1993).	Estradiol	112-121	a1-a	Xenopus laevis	151-154
8186148-4	1994	Here we report on how triiodothyronine (T3) enhances the precocious activation of vitellogenin (Vit) genes by estradiol (E2) in Xenopus tadpoles during metamorphosis.	Triiodothyronine	22-38	a1-a	Xenopus laevis	82-94
8185593-4	1994	A single vitellogenin containing fraction was isolated by chromatography on a Mono-Q column.	Mono Q	78-84	a1-a	Xenopus laevis	9-21
8185593-6	1994	N-terminal sequence analysis and SDS-PAGE demonstrated the presence of two forms of vitellogenin (A and B).	Sodium Dodecyl Sulfate	33-36	a1-a	Xenopus laevis	84-96
8185593-7	1994	Consistent with the conclusions drawn from the teratology which chelating agents induce in frog embryos (1), metal analysis shows that vitellogenin is a zinc protein with 1 g atom zinc/220 kDa monomer but containing no other IIB and transition metals.	Metals	109-114	a1-a	Xenopus laevis	135-147
8186148-4	1994	Here we report on how triiodothyronine (T3) enhances the precocious activation of vitellogenin (Vit) genes by estradiol (E2) in Xenopus tadpoles during metamorphosis.	Triiodothyronine	22-38	a1-a	Xenopus laevis	96-99
8186148-4	1994	Here we report on how triiodothyronine (T3) enhances the precocious activation of vitellogenin (Vit) genes by estradiol (E2) in Xenopus tadpoles during metamorphosis.	Triiodothyronine	40-42	a1-a	Xenopus laevis	82-94
8186148-4	1994	Here we report on how triiodothyronine (T3) enhances the precocious activation of vitellogenin (Vit) genes by estradiol (E2) in Xenopus tadpoles during metamorphosis.	Triiodothyronine	40-42	a1-a	Xenopus laevis	96-99
8186148-4	1994	Here we report on how triiodothyronine (T3) enhances the precocious activation of vitellogenin (Vit) genes by estradiol (E2) in Xenopus tadpoles during metamorphosis.	Estradiol	110-119	a1-a	Xenopus laevis	82-94
8186148-4	1994	Here we report on how triiodothyronine (T3) enhances the precocious activation of vitellogenin (Vit) genes by estradiol (E2) in Xenopus tadpoles during metamorphosis.	Estradiol	110-119	a1-a	Xenopus laevis	96-99
1702515-1	1991	The A2 vitellogenin gene of Xenopus laevis, which is expressed liver specifically, contains an A-activator-binding site (AABS) that mediates high in vitro transcriptional activity in rat liver nuclear extracts.	aabs	121-125	a1-a	Xenopus laevis	7-19
1702515-7	1991	In vitro transcription experiments revealed that AABS was present not only in the closely related Xenopus A1 vitellogenin gene but also in acute-phase genes as a liver-specific regulatory element known to confer the interleukin-6 response.	aabs	49-53	a1-a	Xenopus laevis	109-121
2085692-8	1990	It is possible to follow the route of internalization of vitellogenin-iron conjugates via coated pits, coated vesicles, uncoated vesicles, tubular endosomes, multivesicular endosomes, and light primordial yolk platelets.	Iron	70-74	a1-a	Xenopus laevis	57-69
1970297-2	1990	Vitellogenin conjugated to colloidal ferric particles of ca.	Ferric enterobactin ion	37-43	a1-a	Xenopus laevis	0-12
1970297-4	1990	Several cortical membrane compartments, labeled or unlabeled with ferric particles, are involved in the internalization and the transfer of vitellogenin to the yolk platelets.	Ferric enterobactin ion	66-72	a1-a	Xenopus laevis	140-152
2153117-5	1990	Here we have applied ligand and immunoblotting to visualize the Xenopus laevis oocyte receptor for vitellogenin as a protein with an apparent Mr of 115,000 in sodium dodecyl sulfate-polyacrylamide gels under nonreducing conditions.	Sodium Dodecyl Sulfate	159-181	a1-a	Xenopus laevis	99-111
2153117-5	1990	Here we have applied ligand and immunoblotting to visualize the Xenopus laevis oocyte receptor for vitellogenin as a protein with an apparent Mr of 115,000 in sodium dodecyl sulfate-polyacrylamide gels under nonreducing conditions.	polyacrylamide	182-196	a1-a	Xenopus laevis	99-111
2345348-5	1990	Vitellogenic as well as maturational-stage oocytes were found to sequester X. laevis [32P]VTG from the medium, and incorporation was found to be linear with time for at least up to 12 hr.	Phosphorus-32	86-89	a1-a	Xenopus laevis	90-93
2345348-6	1990	Once incorporated into the oocyte, [32P]VTG did not appear to undergo turnover.	Phosphorus-32	36-39	a1-a	Xenopus laevis	40-43
2345348-7	1990	The effect of different [32P]VTG concentrations on incorporation indicated that the uptake mechanism was saturable.	Phosphorus-32	25-28	a1-a	Xenopus laevis	29-32
2345348-8	1990	Unlabeled F. heteroclitus VTG and X. laevis VTG were also found to compete effectively with X. laevis [32P]VTG, whereas bovine serum albumin did not.	Phosphorus-32	103-106	a1-a	Xenopus laevis	26-29
2345348-8	1990	Unlabeled F. heteroclitus VTG and X. laevis VTG were also found to compete effectively with X. laevis [32P]VTG, whereas bovine serum albumin did not.	Phosphorus-32	103-106	a1-a	Xenopus laevis	44-47