PMID-sentid Pub_year Sent_text comp_official_name comp_offset protein_name organism prot_offset 33236584-4 2020 A typical pattern for CPN-CSS was revealed when compared to O-CSS: lymphopenia vs. pancytopenia and increased vs. decreased fibrinogen. cpn-css 22-29 fibrinogen beta chain Homo sapiens 124-134 32492148-8 2020 CONCLUSIONS: Replacing SFA with carbohydrate decreased factor VIIc and increased fibrinogen in healthy and metabolically unhealthy individuals and also increased PAI-1 in healthy subjects. Carbohydrates 32-44 fibrinogen beta chain Homo sapiens 81-91 32678135-0 2020 Fibrinogen protects neutrophils from the cytotoxic effects of histones and delays neutrophil extracellular trap formation induced by ionomycin. Ionomycin 133-142 fibrinogen beta chain Homo sapiens 0-10 32845987-6 2020 We hypothesized that FCNs would bind to platelets through fibrinogen-GPIIb/IIIa interactions, contributing to hemostasis in the setting of TCP. fcns 21-25 fibrinogen beta chain Homo sapiens 58-68 32579252-8 2020 The risk of thromboembolic events was increased after administration of tranexamic acid (TXA; odds ratio [OR], 2.6; 95% confidence interval [CI], 1.7-4.1; p < 0.001) and fibrinogen concentrate (OR, 2.1; 95% CI, 1.0-4.2; p = 0.04). txa 89-92 fibrinogen beta chain Homo sapiens 170-180 32678135-8 2020 Fibrinogen was responsible for a second distinct mechanism of neutrophil protection after treatment with ionomycin. Ionomycin 105-114 fibrinogen beta chain Homo sapiens 0-10 32678135-9 2020 Fibrinogen clustered on the surface of ionomycin-stimulated neutrophils to delay NETosis; and blocking the beta integrin receptor, alphaMbeta2, abolished fibrinogen protection. Ionomycin 39-48 fibrinogen beta chain Homo sapiens 0-10 32678135-9 2020 Fibrinogen clustered on the surface of ionomycin-stimulated neutrophils to delay NETosis; and blocking the beta integrin receptor, alphaMbeta2, abolished fibrinogen protection. Ionomycin 39-48 fibrinogen beta chain Homo sapiens 154-164 32355990-6 2020 Hypofibrinogenaemia developed at a median of 6 (4-8) days after tigecycline treatment, and the fibrinogen level returned to normal at a median of 3 (3-5) days after tigecycline discontinuation. Tigecycline 64-75 fibrinogen beta chain Homo sapiens 4-14 32508991-8 2020 After treatment with methotrexate 7.5 mg/week, 12 out of 46 patients had elevated blood levels of ESR and 18 out of 46 patients of CRP and fibrinogen. Methotrexate 21-33 fibrinogen beta chain Homo sapiens 139-149 32508991-12 2020 It was concluded that the systemic treatment with both methotrexate and biological therapy showed a marked decline in the patients with abnormal values of CRP, ESR and fibrinogen, indirectly showing a decline in the inflammatory activity of psoriasis. Methotrexate 55-67 fibrinogen beta chain Homo sapiens 168-178 32184141-0 2020 Atypical antipsychotic clozapine binds fibrinogen and affects fibrin formation. Clozapine 23-32 fibrinogen beta chain Homo sapiens 39-49 32184141-4 2020 Our in vitro study aimed to provide insight into molecular bases of this observation, investigating clozapine binding to fibrinogen, the main plasma protein involved in hemostasis. Clozapine 100-109 fibrinogen beta chain Homo sapiens 121-131 32184141-5 2020 Fibrinogen/clozapine interaction was confirmed by protein fluorescence quenching, with an affinity constant of 1.7 x 105 M-1. Clozapine 11-20 fibrinogen beta chain Homo sapiens 0-10 32184141-7 2020 Clozapine binding affected fibrin formation by reducing coagulation speed and thickness of fibrin fibers suggesting that in the presence of clozapine, fibrinogen may acquire thrombogenic characteristics. Clozapine 0-9 fibrinogen beta chain Homo sapiens 151-161 32184141-7 2020 Clozapine binding affected fibrin formation by reducing coagulation speed and thickness of fibrin fibers suggesting that in the presence of clozapine, fibrinogen may acquire thrombogenic characteristics. Clozapine 140-149 fibrinogen beta chain Homo sapiens 151-161 32184141-9 2020 ORAC and HORAC assays showed that clozapine reduced free radical-induced oxidation of fibrinogen. Clozapine 34-43 fibrinogen beta chain Homo sapiens 86-96 32184141-10 2020 All observed effects of clozapine on fibrinogen are dose-dependent, with the effect on fibrin formation being more pronounced. Clozapine 24-33 fibrinogen beta chain Homo sapiens 37-47 32409070-5 2020 TN- and CHI-based PEMs adsorb similar amounts of albumin, whereas fibrinogen adsorption was more pronounced on TN-based PEMs, due to strong association with catechol groups. catechol 157-165 fibrinogen beta chain Homo sapiens 66-76 32292283-1 2020 Introduction: Serum samples of haemodialysed patients collected through vascular access devices, e.g. central venous catheter (CVC) can contain residual heparin, which can cause incomplete clotting and consequently fibrinogen interference in serum protein electrophoresis (SPE). Heparin 153-160 fibrinogen beta chain Homo sapiens 215-225 32292283-7 2020 Conclusion: Fibrinogen interference caused by incomplete clotting because of residual heparin can be overcome by addition of thrombin. Heparin 86-93 fibrinogen beta chain Homo sapiens 12-22 32545422-4 2020 Spectrofluorimetry demonstrated that resveratrol is capable of binding to fibrinogen, the main protein in the coagulation process, which is also important as a food additive. Resveratrol 37-48 fibrinogen beta chain Homo sapiens 74-84 32545422-7 2020 The presence of fibrinogen caused only a negligible masking effect of the antioxidative abilities of resveratrol, measured by a reduction of hexacyanoferrate (III), while greatly increasing its solubility in an aqueous environment, thus increasing its potential bioavailability. Resveratrol 101-112 fibrinogen beta chain Homo sapiens 16-26 32545422-7 2020 The presence of fibrinogen caused only a negligible masking effect of the antioxidative abilities of resveratrol, measured by a reduction of hexacyanoferrate (III), while greatly increasing its solubility in an aqueous environment, thus increasing its potential bioavailability. hexacyanoferrate II 141-157 fibrinogen beta chain Homo sapiens 16-26 32545422-8 2020 Due to its interaction with fibrinogen, resveratrol may serve as an antioxidant at the site of injury. Resveratrol 40-51 fibrinogen beta chain Homo sapiens 28-38 32545422-9 2020 The antioxidative effect of resveratrol may also protect and thus keep the desired characteristics of fibrinogen during the application of this protein as a food additive. Resveratrol 28-39 fibrinogen beta chain Homo sapiens 102-112 32108191-6 2020 In particular, fibrinogen was detected as the main component in the PC of DOXO-BMNPs that potentially provides advantages, e.g. protecting the particles from phagocytosis, thus prolonging their circulation time. doxo-bmnps 74-84 fibrinogen beta chain Homo sapiens 15-25 33178875-5 2020 In addition, the levels of IMA, hs-CRP and FIB levels showed a strong link to BMI, WHR, TC, TG, LDL and glycated hemoglobin. Technetium 88-90 fibrinogen beta chain Homo sapiens 43-46 33178875-5 2020 In addition, the levels of IMA, hs-CRP and FIB levels showed a strong link to BMI, WHR, TC, TG, LDL and glycated hemoglobin. Triglycerides 92-94 fibrinogen beta chain Homo sapiens 43-46 31756482-8 2020 The recombinant Ac-cathL (rAc-cathL) expressed in Escherichia coli exhibited protease activity in acidic pH as demonstrated by gelatin zymography, as well as hydrolytic activity against natural substrates, including BSA, human IgG and human fibrinogen. Actinium 16-18 fibrinogen beta chain Homo sapiens 241-251 31756482-8 2020 The recombinant Ac-cathL (rAc-cathL) expressed in Escherichia coli exhibited protease activity in acidic pH as demonstrated by gelatin zymography, as well as hydrolytic activity against natural substrates, including BSA, human IgG and human fibrinogen. Actinium 27-29 fibrinogen beta chain Homo sapiens 241-251 32355990-7 2020 In the multivariate analysis, intra-abdominal infection (p = 0.005), fibrinogen level at tigecycline initiation (p < 0.001), maintenance dose (p = 0.039), and treatment duration (p = 0.002) were found to be related to hypofibrinogenaemia. Tigecycline 89-100 fibrinogen beta chain Homo sapiens 69-79 32355990-9 2020 CONCLUSION: Tigecycline-associated hypofibrinogenaemia often developed on the 6th (4th-8th) day of tigecycline use and was associated with intra-abdominal infection, fibrinogen level at tigecycline initiation, maintenance dose, and treatment duration of tigecycline but not cefoperazone/sulbactam. Tigecycline 12-23 fibrinogen beta chain Homo sapiens 39-49 32355990-9 2020 CONCLUSION: Tigecycline-associated hypofibrinogenaemia often developed on the 6th (4th-8th) day of tigecycline use and was associated with intra-abdominal infection, fibrinogen level at tigecycline initiation, maintenance dose, and treatment duration of tigecycline but not cefoperazone/sulbactam. Tigecycline 99-110 fibrinogen beta chain Homo sapiens 39-49 32355990-9 2020 CONCLUSION: Tigecycline-associated hypofibrinogenaemia often developed on the 6th (4th-8th) day of tigecycline use and was associated with intra-abdominal infection, fibrinogen level at tigecycline initiation, maintenance dose, and treatment duration of tigecycline but not cefoperazone/sulbactam. Tigecycline 186-197 fibrinogen beta chain Homo sapiens 39-49 32517350-4 2020 Furthermore, significantly lower Vmax was observed for glucose-treated fibrinogen (Vmax 0.046; IQR 0.022-0.085 AU/s) compared to control protein incubated with a pure vehicle (Vmax 0.053; IQR 0.034-0.097 AU/s) (p < 0.05). Glucose 55-62 fibrinogen beta chain Homo sapiens 71-81 32355990-9 2020 CONCLUSION: Tigecycline-associated hypofibrinogenaemia often developed on the 6th (4th-8th) day of tigecycline use and was associated with intra-abdominal infection, fibrinogen level at tigecycline initiation, maintenance dose, and treatment duration of tigecycline but not cefoperazone/sulbactam. Tigecycline 186-197 fibrinogen beta chain Homo sapiens 39-49 32517350-5 2020 The same tendency was observed in the fibrinogen samples supplemented with 6 mM glucose just before measurements. Glucose 80-87 fibrinogen beta chain Homo sapiens 38-48 32355990-9 2020 CONCLUSION: Tigecycline-associated hypofibrinogenaemia often developed on the 6th (4th-8th) day of tigecycline use and was associated with intra-abdominal infection, fibrinogen level at tigecycline initiation, maintenance dose, and treatment duration of tigecycline but not cefoperazone/sulbactam. Cefoperazone 274-286 fibrinogen beta chain Homo sapiens 39-49 32517350-6 2020 It is assumed that glucose may affect the ability of fibrinogen to form a stable clot in T2DM subjects, and that this impairment is likely to influences the outcomes of some diagnostic assays. Glucose 19-26 fibrinogen beta chain Homo sapiens 53-63 32355990-9 2020 CONCLUSION: Tigecycline-associated hypofibrinogenaemia often developed on the 6th (4th-8th) day of tigecycline use and was associated with intra-abdominal infection, fibrinogen level at tigecycline initiation, maintenance dose, and treatment duration of tigecycline but not cefoperazone/sulbactam. Sulbactam 287-296 fibrinogen beta chain Homo sapiens 39-49 32550069-6 2020 Patients" resistance to prophylactic doses of heparin could be due to low levels of anti-thrombin and high levels of fibrinogen, which would reinforce the use of therapeutic doses of heparin in the early stages of hospitalization. Heparin 46-53 fibrinogen beta chain Homo sapiens 117-127 32550069-6 2020 Patients" resistance to prophylactic doses of heparin could be due to low levels of anti-thrombin and high levels of fibrinogen, which would reinforce the use of therapeutic doses of heparin in the early stages of hospitalization. Heparin 183-190 fibrinogen beta chain Homo sapiens 117-127 32105962-6 2020 The results showed that the binding affinities of CdTe QDs and plasma proteins depend on the nature of the protein and follow the order of fibrinogen (FIB)> plasminogen (PLG) > thrombin (TM) > metallothionein-II (MT-II) > human serum albumin (HSA). cadmium telluride 50-54 fibrinogen beta chain Homo sapiens 139-149 32105962-6 2020 The results showed that the binding affinities of CdTe QDs and plasma proteins depend on the nature of the protein and follow the order of fibrinogen (FIB)> plasminogen (PLG) > thrombin (TM) > metallothionein-II (MT-II) > human serum albumin (HSA). cadmium telluride 50-54 fibrinogen beta chain Homo sapiens 151-154 32632589-0 2020 The Structural-Functional Damage of Fibrinogen Oxidized by Hydrogen Peroxide. Hydrogen Peroxide 59-76 fibrinogen beta chain Homo sapiens 36-46 32632589-1 2020 The effect of peroxide-induced oxidation of fibrinogen on modification of its primary structure and functional properties was investigated. Peroxides 14-22 fibrinogen beta chain Homo sapiens 44-54 32204030-0 2020 Konjac glucomannan/polyvinyl alcohol nanofibers with enhanced skin healing properties by improving fibrinogen adsorption. (1-6)-alpha-glucomannan 7-18 fibrinogen beta chain Homo sapiens 99-109 32360964-0 2020 Nanoformulation of fibrinogen by thermal stabilization of its electrostatic complexes with hyaluronic acid. Hyaluronic Acid 91-106 fibrinogen beta chain Homo sapiens 19-29 32360964-2 2020 Electrostatic interaction between hyaluronic acid (HA) and fibrinogen (Fbg) leads to well-defined complexes at acidic pH which however readily dissolve at neutral pH. Hyaluronic Acid 34-49 fibrinogen beta chain Homo sapiens 59-69 32360964-2 2020 Electrostatic interaction between hyaluronic acid (HA) and fibrinogen (Fbg) leads to well-defined complexes at acidic pH which however readily dissolve at neutral pH. Hyaluronic Acid 34-49 fibrinogen beta chain Homo sapiens 71-74 32360964-8 2020 This work shows that the ability of Fbg to self-assemble upon thermal treatment can be effectively used to stabilize Fbg nanoformulations inside complexes with polysaccharides. Polysaccharides 160-175 fibrinogen beta chain Homo sapiens 36-39 32360964-8 2020 This work shows that the ability of Fbg to self-assemble upon thermal treatment can be effectively used to stabilize Fbg nanoformulations inside complexes with polysaccharides. Polysaccharides 160-175 fibrinogen beta chain Homo sapiens 117-120 32204030-0 2020 Konjac glucomannan/polyvinyl alcohol nanofibers with enhanced skin healing properties by improving fibrinogen adsorption. Polyvinyl Alcohol 19-36 fibrinogen beta chain Homo sapiens 99-109 31840798-9 2020 Also, for all concentrations of fibrinogen used, most of the vessel-like structures grew parallel to the direction the PCL frame mediated tensile forces, with very few branching structures observed. starch polycaprolactone 119-122 fibrinogen beta chain Homo sapiens 32-42 32576355-8 2020 On the 6th day of treatment, the plasma thrombin time (TT) in the heparin treatment group was significantly shorter than that on the 3rd day of treatment [s: 30.3 (20.4, 37.0) vs. 34.7 (24.0, 73.4), P < 0.05], and the fibrinogen (FIB) in the heparin treatment group was significantly higher than that in the non-heparin treatment group [g/L: 0.60 (0.31, 1.07) vs. 0.20 (0.14, 0.60), P < 0.01]. Heparin 66-73 fibrinogen beta chain Homo sapiens 218-228 32576355-8 2020 On the 6th day of treatment, the plasma thrombin time (TT) in the heparin treatment group was significantly shorter than that on the 3rd day of treatment [s: 30.3 (20.4, 37.0) vs. 34.7 (24.0, 73.4), P < 0.05], and the fibrinogen (FIB) in the heparin treatment group was significantly higher than that in the non-heparin treatment group [g/L: 0.60 (0.31, 1.07) vs. 0.20 (0.14, 0.60), P < 0.01]. Heparin 66-73 fibrinogen beta chain Homo sapiens 230-233 32344835-4 2020 Calcium levels and fibrinogen binding were normalized to ionomycin-induced responses. Ionomycin 57-66 fibrinogen beta chain Homo sapiens 19-29 33455354-5 2020 Under static conditions, silicones modified with either SMA at concentrations of 10 mumol/g or greater were effective in reducing adhesion of human fibrinogen and platelets. Silicones 25-34 fibrinogen beta chain Homo sapiens 148-158 32391222-5 2020 The patient was transitioned to argatroban and developed an acute drop in the fibrinogen level. argatroban 32-42 fibrinogen beta chain Homo sapiens 78-88 32391222-6 2020 With concern for possible DIC, argatroban was held with a repeat panel six hours later revealing a significantly improved fibrinogen level. argatroban 31-41 fibrinogen beta chain Homo sapiens 122-132 32391222-8 2020 Argatroban may falsely reduce measured fibrinogen levels in vitro, caused by this method. argatroban 0-10 fibrinogen beta chain Homo sapiens 39-49 31903639-0 2020 Sialic acids rather than glycosaminoglycans affect normal and sickle red blood cell rheology by binding to four major sites on fibrinogen. Sialic Acids 0-12 fibrinogen beta chain Homo sapiens 127-137 32369848-5 2020 RESULTS: Circulating 25-hydroxyvitamin D concentrations correlated inversely with baseline platelet binding of fibrinogen to integrin alphaIIbbeta3 (Pearson"s r= -0.172, p = 0.002) and platelet responses to platelet agonist cross-linked collagen-related peptide (CRP-XL) (Pearson"s r= -0.196,p = 0.002). 25-hydroxyvitamin D 22-41 fibrinogen beta chain Homo sapiens 112-122 32369848-9 2020 CONCLUSION: Low circulating vitamin D concentrations are associated with increased platelet fibrinogen binding to integrin alphaIIbbeta3 in unstimulated samples and after stimulation with CRP-XL. Vitamin D 29-38 fibrinogen beta chain Homo sapiens 93-103 32228918-9 2020 CONCLUSIONS: PAMAM-NH2 dendrimers inhibit the extrinsic activation pathway of the coagulation system and alter the conformation and function of fibrinogen. Poly(amidoamine) 13-18 fibrinogen beta chain Homo sapiens 144-154 31889430-0 2020 Fibrinogen alphaC-regions are not directly involved in fibrin polymerization as evidenced by a "Double-Detroit" recombinant fibrinogen mutant and knobs-mimic peptides. Carbon 16-17 fibrinogen beta chain Homo sapiens 0-10 31845492-6 2020 Results obtained showed osteoclasts expressing the enzymes cathepsin K and tartrate resistant acid phosphatase (TRAP) colonizing Fg-3D scaffolds. Tartrates 75-83 fibrinogen beta chain Homo sapiens 129-131 31476464-10 2020 In addition, admission serum fibrinogen was negatively correlated with delayed cerebral ischemia (DCI), and admission serum fibrinogen < 2.5 g/L (OR=3.86, 95% CI=0.99-15.09, p=0.05) was also significantly associated with DCI. dci 98-101 fibrinogen beta chain Homo sapiens 29-39 32183463-10 2020 It was demonstrated that HSA and Fb, which were adsorbed at pH 7.4 and at an ionic strength of 10-3 M, can be fully desorbed by rinsing with a sodium chloride solution at pH 9.0 and ionic strength 0.15 M from the mixed PEO5/PDMAEMA coatings with PEO/PDMAEMA mass ratios of 70/30, and 50/50, respectively. Sodium Chloride 143-158 fibrinogen beta chain Homo sapiens 33-35 32192491-0 2020 Fibrinogen is associated with glucose metabolism and cardiovascular outcomes in patients with coronary artery disease. Glucose 30-37 fibrinogen beta chain Homo sapiens 0-10 32192491-1 2020 BACKGROUND: The present cohort study aims to examine the relationship between fibrinogen (Fib) levels and glucose metabolism [fasting blood glucose (FBG) and hemoglobin A1c (HbA1c)] and investigate the impact of high Fib on cardiovascular outcomes in patients with stable CAD and pre-diabetes mellitus (pre-DM) or diabetes mellitus (DM). Glucose 106-113 fibrinogen beta chain Homo sapiens 78-88 32192491-1 2020 BACKGROUND: The present cohort study aims to examine the relationship between fibrinogen (Fib) levels and glucose metabolism [fasting blood glucose (FBG) and hemoglobin A1c (HbA1c)] and investigate the impact of high Fib on cardiovascular outcomes in patients with stable CAD and pre-diabetes mellitus (pre-DM) or diabetes mellitus (DM). Glucose 106-113 fibrinogen beta chain Homo sapiens 90-93 32192491-9 2020 When patients were stratified by both glucose metabolism status and Fib levels, high Fib was associated with a higher risk of MACEs in pre-DM (HR 1.66, 95% CI 1.02-2.71, P < 0.05). Glucose 38-45 fibrinogen beta chain Homo sapiens 85-88 32104861-5 2020 When a pre-incubated layer of fibrinogen, a protein with high affinity for the gold surface, is present around the nanoparticles before a protein corona is formed in bovine serum, the cellular uptake is significantly increased with an inhibition of ROS. Reactive Oxygen Species 249-252 fibrinogen beta chain Homo sapiens 30-40 32155964-0 2020 Adsorption of Fibrinogen on Silica Surfaces-The Effect of Attached Nanoparticles. Silicon Dioxide 28-34 fibrinogen beta chain Homo sapiens 14-24 32155964-5 2020 The aim of this study was to model adsorption of fibrinogen to smooth or nanostructured silica surfaces in an attempt to further understand how surface nanotopography may affect the orientation of the adsorbed fibrinogen molecule. Silicon Dioxide 88-94 fibrinogen beta chain Homo sapiens 49-59 32016928-10 2020 Fibrinogen levels were higher in the TXA group at 24 hours. Tranexamic Acid 37-40 fibrinogen beta chain Homo sapiens 0-10 31958688-0 2020 Association between higher levels of serum estradiol and elevated levels of fibrin (fibrinogen) degradation products in late pregnancy following assisted reproductive technology treatment. Estradiol 43-52 fibrinogen beta chain Homo sapiens 84-94 32201511-11 2020 High plasma fibrinogen levels were related to poor prognosis in terms of OS (p<0.001), CSS (p<0.001) and PFS (p<0.001). thiocysteine 87-90 fibrinogen beta chain Homo sapiens 12-22 32074981-0 2020 Tigecycline Interferes with Fibrinogen Polymerization Independent of Peripheral Interactions with the Coagulation System. tigecycline 0-11 fibrinogen beta chain Homo sapiens 28-38 32074981-3 2020 The aim of this study was to test whether tigecycline interferes with fibrinogen polymerization by peripheral interactions. tigecycline 42-53 fibrinogen beta chain Homo sapiens 70-80 32074981-9 2020 Although the discrepancy between functional and immunologic fibrinogen levels increased in cell culture assays with tigecycline concentration, fibrinogen levels in spiked plasma samples did not show significant differences determined by functional versus immunologic methods. tigecycline 116-127 fibrinogen beta chain Homo sapiens 60-70 32013056-2 2020 We investigate the possible interaction and the interaction mechanism of a polymeric drug delivery system based on N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers (pHPMA) with the most abundant proteins in human blood plasma-namely, human serum albumin (HSA), immunoglobulin G (IgG), fibrinogen (Fbg), and apolipoprotein (Apo) E4 and A1-using a combination of small-angle X-ray scattering (SAXS), analytical ultracentrifugation (AUC), and nuclear magnetic resonance (NMR). hydroxypropyl methacrylate 168-173 fibrinogen beta chain Homo sapiens 288-298 31846202-10 2020 We also found a biological impact on the results in case of hemolyzed sample: Fibrinogen was decreased when the hemoglobin level was superior to 1.8 g/L, PT was prolonged beyond 5 g/L, and aPTT was shortened beyond 1.5 g/L hemoglobin concentration, especially in patients treated with heparin. Heparin 285-292 fibrinogen beta chain Homo sapiens 78-88 31444987-7 2020 In men without macroprolactinaemia, fenofibrate decreased circulating levels of total and LDL cholesterol, triglycerides, uric acid, hsCRP and fibrinogen, and increased concentrations of HDL cholesterol, homocysteine and 25-hydroxyvitamin D, as well as improved insulin sensitivity. Fenofibrate 36-47 fibrinogen beta chain Homo sapiens 143-153 31759627-11 2020 In terms of in-vivo cartilage formation, the formulation with 30 mg/mL fibrinogen and 100 IU/mL thrombin showed the highest cartilage formation, as evidenced through collagen type II alpha 1 chain (COL2) and safranin-O, 4 weeks after implantation. safranin-o 208-218 fibrinogen beta chain Homo sapiens 71-81 31995579-4 2020 Fibrinogen was in vitro modified by three reagents, namely sodium hypochlorite, malondialdehyde, and 3-morpholinosydnonimine that mimic the oxidative stress in diseases. Sodium Hypochlorite 59-78 fibrinogen beta chain Homo sapiens 0-10 31995579-4 2020 Fibrinogen was in vitro modified by three reagents, namely sodium hypochlorite, malondialdehyde, and 3-morpholinosydnonimine that mimic the oxidative stress in diseases. Malondialdehyde 80-95 fibrinogen beta chain Homo sapiens 0-10 31995579-4 2020 Fibrinogen was in vitro modified by three reagents, namely sodium hypochlorite, malondialdehyde, and 3-morpholinosydnonimine that mimic the oxidative stress in diseases. linsidomine 101-124 fibrinogen beta chain Homo sapiens 0-10 31995579-8 2020 In total, 154 posttranslational modifications were identified, 84 of them were in fibrinogen treated with hypochlorite, 51 resulted from a reaction of fibrinogen with malondialdehyde, and 19 were caused by 3-morpholinosydnonimine. Hypochlorous Acid 106-118 fibrinogen beta chain Homo sapiens 82-92 31995579-8 2020 In total, 154 posttranslational modifications were identified, 84 of them were in fibrinogen treated with hypochlorite, 51 resulted from a reaction of fibrinogen with malondialdehyde, and 19 were caused by 3-morpholinosydnonimine. Malondialdehyde 167-182 fibrinogen beta chain Homo sapiens 151-161 32013056-2 2020 We investigate the possible interaction and the interaction mechanism of a polymeric drug delivery system based on N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers (pHPMA) with the most abundant proteins in human blood plasma-namely, human serum albumin (HSA), immunoglobulin G (IgG), fibrinogen (Fbg), and apolipoprotein (Apo) E4 and A1-using a combination of small-angle X-ray scattering (SAXS), analytical ultracentrifugation (AUC), and nuclear magnetic resonance (NMR). hydroxypropyl methacrylate 168-173 fibrinogen beta chain Homo sapiens 300-303 31407209-7 2020 Four patients exhibited inhibition of ADP-induced platelet activation: one had normal fibrinogen and platelet count, two had concurrent hypofibrinogenemia, and one had concurrent thrombocytopenia. Adenosine Diphosphate 38-41 fibrinogen beta chain Homo sapiens 86-96 31887029-7 2020 Albumin and fibrinogen cause a 52.2% and 78.2% attenuation of the dopamine nanosensor response, coinciding with 0.5% and 3.7% desorption of (GT)6, respectively. Dopamine 66-74 fibrinogen beta chain Homo sapiens 12-22 32021185-7 2020 We specifically shed light on interactions of zeolite nanoparticles with fibrinogen and amyloid beta which had been comprehensively investigated in our recent reports. Zeolites 46-53 fibrinogen beta chain Homo sapiens 73-83 32399109-12 2020 Conclusions: Increased BMI, low Fbg, and simultaneous bilateral TKA could act as risk factors for postoperative symptomatic VTE treated with TXA. Tranexamic Acid 141-144 fibrinogen beta chain Homo sapiens 32-35 31818982-5 2020 We tested IL-5-primed mouse bone marrow-derived and human blood-sorted eosinophil activity against FITC-linked fibrinogen substrates. Fluorescein-5-isothiocyanate 99-103 fibrinogen beta chain Homo sapiens 111-121 31244422-3 2020 OBJECTIVE: This comparative study focuses on methylglyoxal induced glycoxidative damage suffered by immunoglobulin G (IgG) and fibrinogen, and to unveil implication of structural modification of serum proteins in diabetes associated secondary complications. Pyruvaldehyde 45-58 fibrinogen beta chain Homo sapiens 127-137 31244422-7 2020 RESULTS: Structural alterations, increased carbonyl contents and ketoamines were reported in MG glycated IgG and fibrinogen against their native analogues. ketoamines 65-75 fibrinogen beta chain Homo sapiens 113-123 31929250-3 2020 Aims: The aim of the present study was to compare the effectiveness of tranexamic acid and epsilon-amino-caproic acid with respect to postoperative bleeding at 4 and 24 hours as the primary outcome, and rate of postoperative transfusion, re-operations, complication rate, serum fibrinogen, and D-dimer levels as secondary outcomes. Tranexamic Acid 71-86 fibrinogen beta chain Homo sapiens 278-288 31929250-12 2020 Bleeding at 24 hours was significantly lesser in tranexamic acid group as compared to epsilon-amino-caproic acid group, 350 ml (130-520) vs 430 ml (160-730) (P = 0.0022) The rate of transfusion, re-operations, seizures, renal dysfunction, fibrinogen levels, and D-dimer levels did not show significant difference between the groups. Tranexamic Acid 49-64 fibrinogen beta chain Homo sapiens 239-249 31894349-6 2021 Higher effect was observed by combination of fibrinogen with tranexamic acid and prothrombin complex with tranexamic acid, whereas the maximal effect was achieved using all agents together. Tranexamic Acid 106-121 fibrinogen beta chain Homo sapiens 45-55 30585111-12 2020 We expect that plasma from patients treated with ticagrelor (1) contains lower concentrations of EVs from activated platelets, exposing fibrinogen, exposing PS, from leukocytes and from endothelial cells and (2) has lower procoagulant activity, when compared to patients treated with clopidogrel. Ticagrelor 49-59 fibrinogen beta chain Homo sapiens 136-146 31713108-9 2019 Tigecycline-induced coagulopathy usually manifests as the dose-dependent prolongation of prothrombin time and activated partial thromboplastin time and a reduction in the fibrinogen level. Tigecycline 0-11 fibrinogen beta chain Homo sapiens 171-181 32835836-9 2020 Multiple regression analysis adjusted for age, body-mass index, and fibrinogen levels showed that anti-FXa activity, antithrombin activity, and FVIII activity determined Ks, while anti-FXa activity, plasminogen activator inhibitor-1 level, and presence of right ventricular dysfunction determined CLT. Potassium 170-172 fibrinogen beta chain Homo sapiens 68-78 31078915-0 2019 Predicting results of fibrinogen and platelet levels by TEG6s during cardiopulmonary bypass: A pilot study. teg6s 56-61 fibrinogen beta chain Homo sapiens 22-32 31456101-0 2019 Systemic immune-inflammation index, serum albumin, and fibrinogen impact prognosis in castration-resistant prostate cancer patients treated with first-line docetaxel. Docetaxel 156-165 fibrinogen beta chain Homo sapiens 55-65 31456101-10 2019 CONCLUSIONS: Pretreatment SII, albumin, and fibrinogen are independent prognostic factors in mCRPC patients treated with first-line docetaxel. Docetaxel 132-141 fibrinogen beta chain Homo sapiens 44-54 31805717-2 2019 In this study, we developed a selective and sensitive fluorescent HSA probe by fluorescence-based high-throughput screening of a set of fluorescent thieno[3,2-b]pyridine-5(4H)-one derivatives against major plasma proteins: HSA, bovine serum albumin (BSA), globulin, fibrinogen, and transferrin. 4-hydroxy-3-(4-(2-hydroxyphenyl)phenyl)-6-oxo-7H-thieno(2,3-b)pyridine-5-carbonitrile 148-179 fibrinogen beta chain Homo sapiens 266-276 31546221-6 2019 Spectroscopic results showed that TA influenced the structure and conformation of fibrinogen. Tannins 34-36 fibrinogen beta chain Homo sapiens 82-92 31569001-8 2019 As compared to the pristine titanium, the nanotube array structure had the characteristic of selective protein adsorption, and the nanotube array can promote the bovine serum albumin (BSA) adsorption and prevent the fibrinogen (FIB) adsorption, however, the increase of nanotube diameter could reduce BSA adsorption and increase FIB adsorption. Titanium 28-36 fibrinogen beta chain Homo sapiens 216-226 31219873-9 2019 TEG 6s functional fibrinogen level was compared with plasma fibrinogen concentration, measured using the Clauss method. teg 6s 0-6 fibrinogen beta chain Homo sapiens 18-28 31613870-8 2019 The most intense (grade 3) alcian blue staining was significantly correlated with diabetes as well as higher levels of Ca x Pi product, hs-CRP, fibrinogen, SDF-1alpha, PAI-1, and sTM. Alcian Blue 27-38 fibrinogen beta chain Homo sapiens 144-154 31741061-1 2019 Gold nanoclusters (Au NCs) using fibrinogen (FBG) protein as template are fabricated via one-pot reduction strategy, and applied for fluorometric detections of cysteine (Cys) and mercury(II). Mercury 179-186 fibrinogen beta chain Homo sapiens 33-43 31827921-6 2019 Compared with the patients without CIN, the patients developing CIN had lower albumin (39.79 +- 3.95 vs. 37.14 +- 5.21, P=0.012) and higher fibrinogen levels (3.51 +- 0.94 vs. 4.14 +- 0.96, P < 0.001). cin 64-67 fibrinogen beta chain Homo sapiens 140-150 31445013-8 2019 Flow cytometry analysis showed that neferine inhibited thrombin-induced platelet P-selectin expression, PAC-1 and fibrinogen binding. neferine 36-44 fibrinogen beta chain Homo sapiens 114-124 31445013-10 2019 Neferine also inhibited the spreading of human platelets on immobilized fibrinogen. neferine 0-8 fibrinogen beta chain Homo sapiens 72-82 31651923-5 2019 When injected into the subphase beneath a monolayer of the phospholipid dipalmitoylphosphatidylcholine (DPPC, the majority component of LS), fibrinogen preferentially penetrates disordered liquid expanded (LE) regions and accumulates on the boundaries between LE DPPC and liquid condensed (LC) DPPC domains. 1,2-Dipalmitoylphosphatidylcholine 72-102 fibrinogen beta chain Homo sapiens 141-151 31651923-5 2019 When injected into the subphase beneath a monolayer of the phospholipid dipalmitoylphosphatidylcholine (DPPC, the majority component of LS), fibrinogen preferentially penetrates disordered liquid expanded (LE) regions and accumulates on the boundaries between LE DPPC and liquid condensed (LC) DPPC domains. 1,2-Dipalmitoylphosphatidylcholine 104-108 fibrinogen beta chain Homo sapiens 141-151 31651923-5 2019 When injected into the subphase beneath a monolayer of the phospholipid dipalmitoylphosphatidylcholine (DPPC, the majority component of LS), fibrinogen preferentially penetrates disordered liquid expanded (LE) regions and accumulates on the boundaries between LE DPPC and liquid condensed (LC) DPPC domains. 1,2-Dipalmitoylphosphatidylcholine 263-267 fibrinogen beta chain Homo sapiens 141-151 31651923-5 2019 When injected into the subphase beneath a monolayer of the phospholipid dipalmitoylphosphatidylcholine (DPPC, the majority component of LS), fibrinogen preferentially penetrates disordered liquid expanded (LE) regions and accumulates on the boundaries between LE DPPC and liquid condensed (LC) DPPC domains. 1,2-Dipalmitoylphosphatidylcholine 263-267 fibrinogen beta chain Homo sapiens 141-151 31741061-0 2019 Fibrinogen-templated gold nanoclusters for fluorometric determination of cysteine and mercury(II). Cysteine 73-81 fibrinogen beta chain Homo sapiens 0-10 31741061-0 2019 Fibrinogen-templated gold nanoclusters for fluorometric determination of cysteine and mercury(II). Mercury 86-93 fibrinogen beta chain Homo sapiens 0-10 31741061-1 2019 Gold nanoclusters (Au NCs) using fibrinogen (FBG) protein as template are fabricated via one-pot reduction strategy, and applied for fluorometric detections of cysteine (Cys) and mercury(II). Cysteine 160-168 fibrinogen beta chain Homo sapiens 33-43 31741061-1 2019 Gold nanoclusters (Au NCs) using fibrinogen (FBG) protein as template are fabricated via one-pot reduction strategy, and applied for fluorometric detections of cysteine (Cys) and mercury(II). Cysteine 170-173 fibrinogen beta chain Homo sapiens 33-43 31400712-7 2019 Six independent risk factors for TH-ED were identified, including relapse, male, white blood cell (WBC) count above 10 x 109/L, fibrinogen level below 1 g/L, D-dimer level above 4 mg/L and increased creatinine level. th-ed 33-38 fibrinogen beta chain Homo sapiens 128-138 31383585-12 2019 Angiographic control varied between once every 6 h to once every 24 h. In 76% of the SOPs plasma fibrinogen levels were used for CDT dose adjustments. cdt 129-132 fibrinogen beta chain Homo sapiens 97-107 31772853-3 2019 We present a case of an 82-year-old patient who developed a significant decrease of fibrinogen levels after the addition of tigecycline to his antibiotic regimen. tigecycline 124-135 fibrinogen beta chain Homo sapiens 84-94 31325222-9 2019 CONCLUSION: Concentrations of fasting glucose and HbA1c and postprandial glucose response were positively associated with FVIII, FIX, and FXI, and to some extent also with fibrinogen. Glucose 38-45 fibrinogen beta chain Homo sapiens 172-182 31325222-9 2019 CONCLUSION: Concentrations of fasting glucose and HbA1c and postprandial glucose response were positively associated with FVIII, FIX, and FXI, and to some extent also with fibrinogen. Glucose 73-80 fibrinogen beta chain Homo sapiens 172-182 31409451-8 2019 In normoprolactinemic women, atorvastatin decreased circulating levels of uric acid, hsCRP, fibrinogen, homocysteine, and increased concentrations of 25-hydroxyvitamin D, whereas in women with macroprolactinemia the drug decreased levels of hsCRP and homocysteine, as well as impaired insulin sensitivity. Atorvastatin 29-41 fibrinogen beta chain Homo sapiens 92-102 31631975-8 2019 Systolic and diastolic blood pressure values as well as levels of fibrinogen, high-sensitivity C-reactive protein, triglycerides, and alanine aminotransferase were found to be significantly lower after one year of treatment with Perindopril. Perindopril 229-240 fibrinogen beta chain Homo sapiens 66-76 31394994-7 2019 In patients with IVT followed by EVT, baseline fibrinogen level was 3.35+-0.82 g/L and decreased to 2.52+-0.83 g/L immediately after the end of EVT. EVT 33-36 fibrinogen beta chain Homo sapiens 47-57 31115109-1 2019 OBJECTIVES: To investigate if supplementation with fibrinogen concentrate to blood samples collected after tranexamic acid administration improve clot formation more than what can be achieved with fibrinogen in the absence of tranexamic acid. Tranexamic Acid 107-122 fibrinogen beta chain Homo sapiens 51-61 31394994-7 2019 In patients with IVT followed by EVT, baseline fibrinogen level was 3.35+-0.82 g/L and decreased to 2.52+-0.83 g/L immediately after the end of EVT. EVT 144-147 fibrinogen beta chain Homo sapiens 47-57 31418579-8 2019 Toward novel scaffolds for wound healing, which are stable in aqueous environment, we also introduced cross-linking of fibrinogen scaffolds in formaldehyde vapor. Formaldehyde 143-155 fibrinogen beta chain Homo sapiens 119-129 31265849-1 2019 We present a computational analysis coupled with experimental studies, focusing on the binding-interaction between beta-adrenoreceptor blocking agents (acebutolol and propranolol) with fibrinogen protein (E-region). Acebutolol 152-162 fibrinogen beta chain Homo sapiens 185-195 31265849-1 2019 We present a computational analysis coupled with experimental studies, focusing on the binding-interaction between beta-adrenoreceptor blocking agents (acebutolol and propranolol) with fibrinogen protein (E-region). Propranolol 167-178 fibrinogen beta chain Homo sapiens 185-195 31265849-5 2019 In this regard, we identify a docking-mechanism of interaction for the propranolol and acebutolol mainly based on non-covalent hydrophobic contacts with the fibrinogen E-region binding-site. Propranolol 71-82 fibrinogen beta chain Homo sapiens 157-167 31265849-5 2019 In this regard, we identify a docking-mechanism of interaction for the propranolol and acebutolol mainly based on non-covalent hydrophobic contacts with the fibrinogen E-region binding-site. Acebutolol 87-97 fibrinogen beta chain Homo sapiens 157-167 31265849-9 2019 The combined experimental results point out that acebutolol acts to a lesser extent to fibrinogen structure than propranolol. Acebutolol 49-59 fibrinogen beta chain Homo sapiens 87-97 31370073-8 2019 ATRA-treated platelets demonstrated reduced spreading on immobilized fibrinogen or collagen and reduced thrombin-induced clot retraction together with reduced phosphorylation of Syk and PLCgamma2. Tretinoin 0-4 fibrinogen beta chain Homo sapiens 69-79 31547461-8 2019 As expected, application of high dose of copper induced expression of fibrinogen, while knockdown of ceruloplasmin also resulted in upregulation of fibrinogen as well as elimination of superoxide dismutase (SOD), leading to increased oxidative stress in cells. Copper 41-47 fibrinogen beta chain Homo sapiens 70-80 31136867-0 2019 Exploring the conformational changes in fibrinogen by forming protein corona with CdTe quantum dots and the related cytotoxicity. cadmium telluride 82-86 fibrinogen beta chain Homo sapiens 40-50 31136867-1 2019 This study describes synthesis of N-acetyl-l-cysteine-capped CdTe quantum dots (QDs) and investigates their interaction with plasma protein fibrinogen (FIB) and the structural changes of FIB. Acetylcysteine 34-53 fibrinogen beta chain Homo sapiens 140-150 31136867-1 2019 This study describes synthesis of N-acetyl-l-cysteine-capped CdTe quantum dots (QDs) and investigates their interaction with plasma protein fibrinogen (FIB) and the structural changes of FIB. Acetylcysteine 34-53 fibrinogen beta chain Homo sapiens 152-155 31136867-1 2019 This study describes synthesis of N-acetyl-l-cysteine-capped CdTe quantum dots (QDs) and investigates their interaction with plasma protein fibrinogen (FIB) and the structural changes of FIB. Acetylcysteine 34-53 fibrinogen beta chain Homo sapiens 187-190 31136867-1 2019 This study describes synthesis of N-acetyl-l-cysteine-capped CdTe quantum dots (QDs) and investigates their interaction with plasma protein fibrinogen (FIB) and the structural changes of FIB. cadmium telluride 61-65 fibrinogen beta chain Homo sapiens 140-150 31136867-1 2019 This study describes synthesis of N-acetyl-l-cysteine-capped CdTe quantum dots (QDs) and investigates their interaction with plasma protein fibrinogen (FIB) and the structural changes of FIB. cadmium telluride 61-65 fibrinogen beta chain Homo sapiens 152-155 31136867-1 2019 This study describes synthesis of N-acetyl-l-cysteine-capped CdTe quantum dots (QDs) and investigates their interaction with plasma protein fibrinogen (FIB) and the structural changes of FIB. cadmium telluride 61-65 fibrinogen beta chain Homo sapiens 187-190 31136867-2 2019 It is shown that the interaction of QDs with FIB is a spontaneous process and the major driving forces are van der Waals forces and hydrogen bonds. Hydrogen 132-140 fibrinogen beta chain Homo sapiens 45-48 31136867-6 2019 The coating of FIB on QDs could lower intracellular QDs uptake and therefore result in less released cadmium ions and ROS productions. Cadmium 101-108 fibrinogen beta chain Homo sapiens 15-18 31136867-6 2019 The coating of FIB on QDs could lower intracellular QDs uptake and therefore result in less released cadmium ions and ROS productions. ros 118-121 fibrinogen beta chain Homo sapiens 15-18 31129523-9 2019 The persulfates modified substrates reduced the amount of adsorbed fibrinogen and albumin with higher stability to fetal bovine serum. persulfates 4-15 fibrinogen beta chain Homo sapiens 67-77 31372962-10 2019 MAthrombin and fibrinogen were meaningful mediators for the significant positive association of the number of narrowed vessels and HRPR on clopidogrel, which were enhanced by around 30% and 43%, respectively, for this effect. Clopidogrel 139-150 fibrinogen beta chain Homo sapiens 15-25 31394033-0 2019 Mechanisms of Fibrinogen Adsorption on Silica Sensors at Various pHs: Experiments and Theoretical Modeling. Silicon Dioxide 39-45 fibrinogen beta chain Homo sapiens 14-24 31394033-1 2019 The adsorption kinetics of human serum fibrinogen at silica substrates was studied using optical waveguide lightmode spectroscopy (OWLS) and quartz crystal microbalance (QCM) techniques. Silicon Dioxide 53-59 fibrinogen beta chain Homo sapiens 39-49 31394033-5 2019 The appearance of different, pH-dependent mechanisms of fibrinogen adsorption on silica substrates was confirmed. Silicon Dioxide 81-87 fibrinogen beta chain Homo sapiens 56-66 31282164-0 2019 In Situ Single-Molecule AFM Investigation of Surface-Induced Fibrinogen Unfolding on Graphite. Graphite 85-93 fibrinogen beta chain Homo sapiens 61-71 31150674-2 2019 In this work, iron oxide nanoparticles-decorated carboxylated graphene oxide nanosheets (Fe3O4/cGO nanohybrid) were synthesized and incorporated in polyethersulfone (PES) hollow fiber ultrafiltration membranes (HFMs) and the resulting modified membranes were evaluated for the separation of proteins, namely lysozyme, trypsin, pepsin, human serum albumin, gamma-globulin and fibrinogen. ferric oxide 14-24 fibrinogen beta chain Homo sapiens 341-385 31150674-2 2019 In this work, iron oxide nanoparticles-decorated carboxylated graphene oxide nanosheets (Fe3O4/cGO nanohybrid) were synthesized and incorporated in polyethersulfone (PES) hollow fiber ultrafiltration membranes (HFMs) and the resulting modified membranes were evaluated for the separation of proteins, namely lysozyme, trypsin, pepsin, human serum albumin, gamma-globulin and fibrinogen. ferryl iron 89-94 fibrinogen beta chain Homo sapiens 341-385 31150674-5 2019 PES-Fe3O4/cGO composite HFMs showed significantly high rejection of lysozyme (92.9 +- 1.3%), trypsin (94.5 +- 1.1%), pepsin (96.9 +- 1.2%), human serum albumin (99.5 +- 0.5%), human gamma-globulin (100%), and human fibrinogen (100%). polyether sulfone 0-3 fibrinogen beta chain Homo sapiens 215-225 31150674-5 2019 PES-Fe3O4/cGO composite HFMs showed significantly high rejection of lysozyme (92.9 +- 1.3%), trypsin (94.5 +- 1.1%), pepsin (96.9 +- 1.2%), human serum albumin (99.5 +- 0.5%), human gamma-globulin (100%), and human fibrinogen (100%). ferryl iron 4-9 fibrinogen beta chain Homo sapiens 215-225 31150674-5 2019 PES-Fe3O4/cGO composite HFMs showed significantly high rejection of lysozyme (92.9 +- 1.3%), trypsin (94.5 +- 1.1%), pepsin (96.9 +- 1.2%), human serum albumin (99.5 +- 0.5%), human gamma-globulin (100%), and human fibrinogen (100%). cgo 10-13 fibrinogen beta chain Homo sapiens 215-225 30973284-4 2019 The lung tissue was investigated by microscopy after autopsy using a fluorescein-marked polyclonal antibody against fibrinogen as a marker for clots preformed before death. Fluorescein 69-80 fibrinogen beta chain Homo sapiens 116-126 31282164-3 2019 Understanding the conformational dynamics of fibrinogen molecules adsorbed on solid surfaces is, therefore, of great interest in biomedicine and may contribute to the development of new biomaterials. biomedicine 129-140 fibrinogen beta chain Homo sapiens 45-55 31257890-4 2019 On films of poly(desaminotyrosyl-tyrosine-co-PEG carbonate) with high (20 wt %) PEG content, in which very little protein adsorption is expected, quartz crystal microbalance data showed significant adsorption of fibrinogen and bovine serum albumin at 8 C. The surface became protein-repellent at 37.5 C. When the same polymer was iodinated, the polymer was protein-adsorbent, even when 37 wt % PEG was incorporated into the polymer backbone. poly(desaminotyrosyl-tyrosine-co-peg carbonate 12-58 fibrinogen beta chain Homo sapiens 212-222 31257890-4 2019 On films of poly(desaminotyrosyl-tyrosine-co-PEG carbonate) with high (20 wt %) PEG content, in which very little protein adsorption is expected, quartz crystal microbalance data showed significant adsorption of fibrinogen and bovine serum albumin at 8 C. The surface became protein-repellent at 37.5 C. When the same polymer was iodinated, the polymer was protein-adsorbent, even when 37 wt % PEG was incorporated into the polymer backbone. Polymers 320-327 fibrinogen beta chain Homo sapiens 212-222 31282164-4 2019 In this work, unfolding of fibrinogen molecules adsorbed on a model surface (highly oriented pyrolytic graphite modified with an oligoglycine-hydrocarbon graphite modifier) is directly visualized using time-lapse atomic force microscopy. Graphite 103-111 fibrinogen beta chain Homo sapiens 27-37 31282164-4 2019 In this work, unfolding of fibrinogen molecules adsorbed on a model surface (highly oriented pyrolytic graphite modified with an oligoglycine-hydrocarbon graphite modifier) is directly visualized using time-lapse atomic force microscopy. oligoglycine-hydrocarbon 129-153 fibrinogen beta chain Homo sapiens 27-37 31282164-4 2019 In this work, unfolding of fibrinogen molecules adsorbed on a model surface (highly oriented pyrolytic graphite modified with an oligoglycine-hydrocarbon graphite modifier) is directly visualized using time-lapse atomic force microscopy. Graphite 154-162 fibrinogen beta chain Homo sapiens 27-37 31282164-8 2019 The obtained results provide a new, direct insight into the unfolding of individual fibrinogen molecules on a surface and give new opportunities for the development of graphite-based biosensors and biomaterials. Graphite 168-176 fibrinogen beta chain Homo sapiens 84-94 31347309-10 2019 Patients with high plasma fibrinogen concentrations and low 25-OH vitamin D levels had lower lung function, higher severity index, and higher annual rate of severe exacerbations 12 months before (0.23/year) and after (0.41/year) the measurement of 25-OH vitamin D levels than did the other patients. 25-oh 248-253 fibrinogen beta chain Homo sapiens 26-36 31347309-10 2019 Patients with high plasma fibrinogen concentrations and low 25-OH vitamin D levels had lower lung function, higher severity index, and higher annual rate of severe exacerbations 12 months before (0.23/year) and after (0.41/year) the measurement of 25-OH vitamin D levels than did the other patients. Vitamin D 254-263 fibrinogen beta chain Homo sapiens 26-36 31347309-12 2019 The measurement of plasma fibrinogen concentrations could help identify a severe phenotypic group among patients with vitamin D deficiency. Vitamin D 118-127 fibrinogen beta chain Homo sapiens 26-36 30587667-6 2019 RESULTS: There were significantly positive associations between sdLDL-C concentration and traditional (age, smoking and alcohol drinking habit, blood pressure, body mass index (BMI), serum lipid profiles, and diabetes status) and nontraditional risk factors (complete blood counts, (CBC), fibrinogen, high-sensitivity C-reactive protein, and subclinical diabetes status) for CVD. sdldl-c 64-71 fibrinogen beta chain Homo sapiens 289-299 31244253-0 2019 Adsorption of Fibrinogen and Fibronectin on Elastomeric Poly(butylene succinate) Copolyesters. poly(butylene succinate) copolyesters 56-93 fibrinogen beta chain Homo sapiens 14-24 31393394-6 2019 The later the N stages (P = .002), M stages (P = .002), and CS (P = .001) were, the higher the average plasma Fbg levels were. Cesium 60-62 fibrinogen beta chain Homo sapiens 110-113 31393394-7 2019 The levels of squamous cell carcinoma antigen (P = .001), carbohydrate antigen 125 (P = .041), and neuron-specific enolase (P < .001) were positively correlated with plasma Fbg concentration. Carbohydrates 58-70 fibrinogen beta chain Homo sapiens 176-179 31393394-8 2019 The plasma level of Fbg in lung adenocarcinoma patients (P < .001) was the lowest, while that of lung squamous cell carcinoma patients (P < .001) was the highest in NSCLC patients.The plasma Fbg concentration is related to gender, CS, and tumor markers in patients with NSCLC. Cesium 237-239 fibrinogen beta chain Homo sapiens 20-23 31337804-7 2019 Citrate dialysis increased HD efficacy and reduced plasma levels of CRP, fibrinogen, IL6 and chemerin. Citric Acid 0-7 fibrinogen beta chain Homo sapiens 73-83 31259773-0 2019 Phenotypic and genetic analysis of hypofibrinogenemia because of a novel missense mutation in the FGB: Leu121Arg. leu121arg 103-112 fibrinogen beta chain Homo sapiens 98-101 31272567-9 2019 In mediation analysis, the association between bezafibrate treatment and cancer incidence was not sensitive to adjustment for on-trial lipid levels but was attenuated on adjustment for on-trial fibrinogen levels. Bezafibrate 47-58 fibrinogen beta chain Homo sapiens 194-204 30318393-7 2019 With phentolamine + NE, fibrinogen levels remained increased compared to saline + saline, but changes in FVIII:C and D-dimer levels were no more different. Phentolamine 5-17 fibrinogen beta chain Homo sapiens 24-34 31055797-0 2019 Evaluating the Effects of Fibrinogen alphaC Mutations on the Ability of Factor XIII to Crosslink the Reactive alphaC Glutamines (Q237, Q328, Q366). Glutamine 117-127 fibrinogen beta chain Homo sapiens 26-36 31250576-5 2019 Platelet and fibrinogen levels in the apixaban group were lower than those of the LMWH group. apixaban 38-46 fibrinogen beta chain Homo sapiens 13-23 31070898-1 2019 This work describes the interaction of the human blood plasma proteins albumin, fibrinogen, and gamma-globulins with micro- and nanopatterned polymer interfaces. Polymers 142-149 fibrinogen beta chain Homo sapiens 80-90 33405589-10 2019 In vitro hemocompatibility evaluation, including hemolysis rate, denaturation of adsorbed fibrinogen, and platelet adhesion and activation, indicated that Au-PEG-ACH11 possessed good hemocompatibility. au-peg-ach11 155-167 fibrinogen beta chain Homo sapiens 90-100 31163666-6 2019 Furthermore, we found the slight hemolysis of the TA coating caused by the lysed red blood cells and adsorption of protein, especially the clotting-related fibrinogen, resulted in excellent hemostasis performance of the TA coating in the blood clotting of an animal wound. Tannins 50-52 fibrinogen beta chain Homo sapiens 156-166 31098664-12 2019 Logistic regression revealed hemoglobin (Hb) and fibrinogen levels at admission to be independent predictors for a decreased platelet activation in the assay with ADP (p < 0.001, Cohen"s f = 0.61) and with epinephrine (p < 0.001, f = 0.42). Adenosine Diphosphate 163-166 fibrinogen beta chain Homo sapiens 49-59 31098664-12 2019 Logistic regression revealed hemoglobin (Hb) and fibrinogen levels at admission to be independent predictors for a decreased platelet activation in the assay with ADP (p < 0.001, Cohen"s f = 0.61) and with epinephrine (p < 0.001, f = 0.42). Epinephrine 206-217 fibrinogen beta chain Homo sapiens 49-59 31139195-10 2019 In particular, it was shown that neutrophils, mainly through NADPH oxidase, produce excessive amounts of reactive oxygen species (ROS), which are able to markedly modify the secondary structure of fibrinogen and hence the overall architecture of the fibrin clot that becomes less susceptible to plasmin-induced lysis. Reactive Oxygen Species 105-128 fibrinogen beta chain Homo sapiens 197-207 31139195-10 2019 In particular, it was shown that neutrophils, mainly through NADPH oxidase, produce excessive amounts of reactive oxygen species (ROS), which are able to markedly modify the secondary structure of fibrinogen and hence the overall architecture of the fibrin clot that becomes less susceptible to plasmin-induced lysis. Reactive Oxygen Species 130-133 fibrinogen beta chain Homo sapiens 197-207 31139195-12 2019 In particular, it is suggested that an alteration in fibrinogen structure and function are associated with enhanced ROS production via neutrophil NADPH oxidase. Reactive Oxygen Species 116-119 fibrinogen beta chain Homo sapiens 53-63 31012009-0 2019 Hypochlorite-Induced Oxidative Modification of Fibrinogen. Hypochlorous Acid 0-12 fibrinogen beta chain Homo sapiens 47-57 31012009-1 2019 Oxidation of fibrinogen with hypochlorite inhibited the fibrin network self-assembly even at the lowest concentration of the oxidant. Hypochlorous Acid 29-41 fibrinogen beta chain Homo sapiens 13-23 31239595-0 2019 Fibrinogen levels measured by the dry hematology method are lower than those measured by the Clauss method under a high concentration of heparin. Heparin 137-144 fibrinogen beta chain Homo sapiens 0-10 31239595-9 2019 In patients on high-dose heparin, the mean fibrinogen level measured by the DH method was significantly lower than that measured by the Clauss method. Heparin 25-32 fibrinogen beta chain Homo sapiens 43-53 31239595-9 2019 In patients on high-dose heparin, the mean fibrinogen level measured by the DH method was significantly lower than that measured by the Clauss method. 2-(3,5-dihydroxyphenyl)-6-hydroxybenzothiazole 76-78 fibrinogen beta chain Homo sapiens 43-53 30742030-7 2019 Fibrinogen binding and degranulation responses to ADP were significantly reduced in suspected septic neonates (n = 6) and the Fibrinogen Binding scores clearly separated the septic and healthy group (88.2 +- 10.3 vs 38.6 +- 12.2, P = 0.03). Adenosine Diphosphate 50-53 fibrinogen beta chain Homo sapiens 0-10 31112078-1 2019 In the current study, we have developed predictive quantitative structure-activity relationship (QSAR) models for cellular response (foetal rate lung fibroblast proliferation) and protein adsorption (fibrinogen adsorption (FA)) on the surface of tyrosine-derived biodegradable polymers designed for tissue engineering purpose using a dataset of 66 and 40 biodegradable polymers, respectively, employing two-dimensional molecular descriptors. Tyrosine 246-254 fibrinogen beta chain Homo sapiens 200-210 30897531-9 2019 We found an inverse association between fibrinogen and fibrinogen gamma" and IPH volume (B = -23.40 mm3/g/L, p = 0.01 and B = -161.73 mm3/g/L, p = 0.01) and between fibrinogen and fibrinogen gamma" and LRNC volume (B = -38.89 mm3 g/L, p < 0.01 and B = -227.06 mm3 g/L, p = 0.01). iph 77-80 fibrinogen beta chain Homo sapiens 40-50 30897531-9 2019 We found an inverse association between fibrinogen and fibrinogen gamma" and IPH volume (B = -23.40 mm3/g/L, p = 0.01 and B = -161.73 mm3/g/L, p = 0.01) and between fibrinogen and fibrinogen gamma" and LRNC volume (B = -38.89 mm3 g/L, p < 0.01 and B = -227.06 mm3 g/L, p = 0.01). iph 77-80 fibrinogen beta chain Homo sapiens 55-65 30897531-9 2019 We found an inverse association between fibrinogen and fibrinogen gamma" and IPH volume (B = -23.40 mm3/g/L, p = 0.01 and B = -161.73 mm3/g/L, p = 0.01) and between fibrinogen and fibrinogen gamma" and LRNC volume (B = -38.89 mm3 g/L, p < 0.01 and B = -227.06 mm3 g/L, p = 0.01). iph 77-80 fibrinogen beta chain Homo sapiens 55-65 30897531-9 2019 We found an inverse association between fibrinogen and fibrinogen gamma" and IPH volume (B = -23.40 mm3/g/L, p = 0.01 and B = -161.73 mm3/g/L, p = 0.01) and between fibrinogen and fibrinogen gamma" and LRNC volume (B = -38.89 mm3 g/L, p < 0.01 and B = -227.06 mm3 g/L, p = 0.01). iph 77-80 fibrinogen beta chain Homo sapiens 55-65 30935261-0 2019 Ozone-induced damage of fibrinogen molecules: identification of oxidation sites by high-resolution mass spectrometry. Ozone 0-5 fibrinogen beta chain Homo sapiens 24-34 30935261-3 2019 Ozone-induced oxidative modifications of the fibrinogen Aalpha, Bbeta, and gamma polypeptide chains upon addition of various amounts of the oxidiser were studied by mass spectrometry. Ozone 0-5 fibrinogen beta chain Homo sapiens 45-55 30935261-9 2019 New findings presented here could be essential for the detection of adaptive molecular mechanisms capable of mitigating the detrimental action of reactive oxygen species (ROS) on the functioning of oxidatively damaged fibrinogen. Reactive Oxygen Species 146-169 fibrinogen beta chain Homo sapiens 218-228 30935261-9 2019 New findings presented here could be essential for the detection of adaptive molecular mechanisms capable of mitigating the detrimental action of reactive oxygen species (ROS) on the functioning of oxidatively damaged fibrinogen. Reactive Oxygen Species 171-174 fibrinogen beta chain Homo sapiens 218-228 30935261-11 2019 Highlights Various oxidative modifications were detected in fibrinogen by mass spectrometry alphaC-connector has been shown to be most susceptible to oxidation E region proved to be least vulnerable to the action of the oxidising agent Some of the Met residues in the fibrinogen structure could operate as ROS scavengers. Reactive Oxygen Species 306-309 fibrinogen beta chain Homo sapiens 60-70 30935261-11 2019 Highlights Various oxidative modifications were detected in fibrinogen by mass spectrometry alphaC-connector has been shown to be most susceptible to oxidation E region proved to be least vulnerable to the action of the oxidising agent Some of the Met residues in the fibrinogen structure could operate as ROS scavengers. Reactive Oxygen Species 306-309 fibrinogen beta chain Homo sapiens 268-278 30462259-5 2019 Among treatment-adherent patients with pretreatment plasma fibrinogen <=2 g/l, greater reduction in 5-min bleeding mass was seen with FCH versus placebo (median -22.5 g vs -15.5 g; P = 0.071). fluorocholine 134-137 fibrinogen beta chain Homo sapiens 59-69 31356179-15 2019 The PIA1 allele may be a potential factor for aspirin resistance with elevated fibrinogen concentration. Aspirin 46-53 fibrinogen beta chain Homo sapiens 79-89 31325812-3 2019 Using linear regression, we found that neighbourhood-level nitrogen dioxide predicted later levels of fibrinogen, but not C-reactive protein. Nitrogen 59-67 fibrinogen beta chain Homo sapiens 102-112 31355062-4 2019 The complex pathophysiology of widespread prothrombotic state caused by cocaine includes endothelial damage promoting the increase of fibrinogen and Von Willebrand factor to platelet aggregation and clot formation. Cocaine 72-79 fibrinogen beta chain Homo sapiens 134-144 30798066-7 2019 Furthermore, the PVP bottle-brushes reduced the levels of BSA, Fg and Lyz adsorption by 97%, 85% and 69%, respectively. Povidone 17-20 fibrinogen beta chain Homo sapiens 63-65 30684573-0 2019 Characterisation and the effects of bilirubin binding to human fibrinogen. Bilirubin 36-45 fibrinogen beta chain Homo sapiens 63-73 30684573-4 2019 The present paper describes interaction between fibrinogen and bilirubin, and the influence of bilirubin on the formation of fibrin and protection against oxidation. Bilirubin 63-72 fibrinogen beta chain Homo sapiens 48-58 30684573-5 2019 The binding constant of 4.5 x 104 M-1 was determined for the fibrinogen/bilirubin complex at 37 C. There is no change in secondary and tertiary structure of fibrinogen or its thermal stability upon bilirubin binding. Bilirubin 72-81 fibrinogen beta chain Homo sapiens 61-71 30684573-6 2019 The binding site of fibrinogen is not stereospecific for bilirubin and is able to accommodate both bilirubin conformers. Bilirubin 57-66 fibrinogen beta chain Homo sapiens 20-30 30684573-6 2019 The binding site of fibrinogen is not stereospecific for bilirubin and is able to accommodate both bilirubin conformers. Bilirubin 99-108 fibrinogen beta chain Homo sapiens 20-30 30684573-7 2019 A change in absorption maximum of bilirubin occurs upon its interaction with fibrinogen, suggesting an alteration in the conformation of bilirubin to the more cyclic one. Bilirubin 34-43 fibrinogen beta chain Homo sapiens 77-87 30684573-7 2019 A change in absorption maximum of bilirubin occurs upon its interaction with fibrinogen, suggesting an alteration in the conformation of bilirubin to the more cyclic one. Bilirubin 137-146 fibrinogen beta chain Homo sapiens 77-87 30684573-8 2019 Bilirubin exerts antioxidant effect on fibrinogen, preventing its carbonylation and aggregation. Bilirubin 0-9 fibrinogen beta chain Homo sapiens 39-49 30684573-10 2019 Fibrinogen and bilirubin interact at physiological concentrations, bilirubin may act as an antioxidant for fibrinogen and may modulate an important event in haemostasis, which altogether suggests possible physiological relevance of this interaction. Bilirubin 15-24 fibrinogen beta chain Homo sapiens 107-117 30684573-10 2019 Fibrinogen and bilirubin interact at physiological concentrations, bilirubin may act as an antioxidant for fibrinogen and may modulate an important event in haemostasis, which altogether suggests possible physiological relevance of this interaction. Bilirubin 67-76 fibrinogen beta chain Homo sapiens 0-10 30684573-10 2019 Fibrinogen and bilirubin interact at physiological concentrations, bilirubin may act as an antioxidant for fibrinogen and may modulate an important event in haemostasis, which altogether suggests possible physiological relevance of this interaction. Bilirubin 67-76 fibrinogen beta chain Homo sapiens 107-117 30958432-9 2019 Fibrinogen was significantly associated with all-cause mortality according to multivariate Cox regression (hazard ratio 1.339, 95% confidence interval: 1.109-1.763, P = 0.005), together with traditional risk factors including age, sex, diabetes mellitus, left ventricular ejection fraction, creatinine clearance, and low-density lipoprotein cholesterol. Creatinine 291-301 fibrinogen beta chain Homo sapiens 0-10 30999626-8 2019 Participants who were classified as at "moderate risk" compared to "lower-risk" based on a ceramide risk score had significantly higher body mass index (BMI) values, as well as higher rates of elevated fibrinogen levels, metabolic syndrome, and former smoking status. Ceramides 91-99 fibrinogen beta chain Homo sapiens 202-212 30444954-9 2019 Low platelet count postpartum (defined as <= 150 x 109 /L) and high fibrinogen pre-CS (defined as >= 4.5 g/L) increased CSD risk (aOR 2.0, 95% CI 1.1-3.6 and 1.7, 95% CI 1.1-2.5, respectively). Aminoglutethimide 98-104 fibrinogen beta chain Homo sapiens 71-81 30511382-11 2019 Combined fibrinogen and platelet transfusion shortened clotting time (P = 0.005) and increased clot stability (P = 0.001), and improved arachidonic acid- and TRAP-induced platelet aggregation (P = 0.004 and 0.016 respectively), and increased fibrinogen concentration and platelet count. Arachidonic Acid 136-152 fibrinogen beta chain Homo sapiens 9-19 30625358-4 2019 In the present study, fibrinogen was incubated with varying concentration of MGO for 7 days followed by its biochemical and biophysical analysis. Pyruvaldehyde 77-80 fibrinogen beta chain Homo sapiens 22-32 30625358-5 2019 Glycated plasma fibrinogen (MGO-fibrinogen); exhibited hyperchromicity, a drop in tryptophan and intrinsic fluorescence, augmented AGE-specific fluorescence and melting temperature. Tryptophan 82-92 fibrinogen beta chain Homo sapiens 16-26 30625358-5 2019 Glycated plasma fibrinogen (MGO-fibrinogen); exhibited hyperchromicity, a drop in tryptophan and intrinsic fluorescence, augmented AGE-specific fluorescence and melting temperature. Tryptophan 82-92 fibrinogen beta chain Homo sapiens 32-42 30625358-6 2019 Sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) results showed decrease in mobility of MGO-fibrinogen. Sodium Dodecyl Sulfate 0-22 fibrinogen beta chain Homo sapiens 112-122 30625358-6 2019 Sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) results showed decrease in mobility of MGO-fibrinogen. polyacrylamide 23-37 fibrinogen beta chain Homo sapiens 112-122 30625358-6 2019 Sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) results showed decrease in mobility of MGO-fibrinogen. Sodium Dodecyl Sulfate 59-62 fibrinogen beta chain Homo sapiens 112-122 30737131-5 2019 Fibrinogen-induced spine elimination was prevented by inhibiting reactive oxygen species (ROS) generation or genetic ablation of CD11b. Reactive Oxygen Species 65-88 fibrinogen beta chain Homo sapiens 0-10 30737131-5 2019 Fibrinogen-induced spine elimination was prevented by inhibiting reactive oxygen species (ROS) generation or genetic ablation of CD11b. Reactive Oxygen Species 90-93 fibrinogen beta chain Homo sapiens 0-10 30445261-4 2019 Considering that fibrinogen stabilized citrate-capped AuNPs against a high-ionic-strength buffer, F-AuNPs efficiently catalyzed the NaBH4-mediated decrease of yellow 4-nitrophenol to colorless 4-aminophenol. Citric Acid 39-46 fibrinogen beta chain Homo sapiens 17-27 30445261-4 2019 Considering that fibrinogen stabilized citrate-capped AuNPs against a high-ionic-strength buffer, F-AuNPs efficiently catalyzed the NaBH4-mediated decrease of yellow 4-nitrophenol to colorless 4-aminophenol. sodium borohydride 132-137 fibrinogen beta chain Homo sapiens 17-27 30445261-4 2019 Considering that fibrinogen stabilized citrate-capped AuNPs against a high-ionic-strength buffer, F-AuNPs efficiently catalyzed the NaBH4-mediated decrease of yellow 4-nitrophenol to colorless 4-aminophenol. 4-nitrophenol 166-179 fibrinogen beta chain Homo sapiens 17-27 30829217-0 2019 Fabrication of 3D-nanofibrous fibrinogen scaffolds using salt-induced self assembly. Salts 57-61 fibrinogen beta chain Homo sapiens 30-40 30829217-2 2019 Here, we introduce a novel biofabrication technique to prepare three-dimensional, nanofibrous fibrinogen scaffolds by salt-induced self assembly. Salts 118-122 fibrinogen beta chain Homo sapiens 94-104 30829217-7 2019 By adjusting the salt concentration we could prepare fibrinogen scaffolds with overall dimensions in the centimeter range and a thickness of 3 to 5 mum. Salts 17-21 fibrinogen beta chain Homo sapiens 53-63 30829217-8 2019 Using FTIR analysis we observed peak shifts of the amide bands for fibrinogen nanofibers in comparison to planar fibrinogen, which indicates changes in the secondary structure. Amides 51-56 fibrinogen beta chain Homo sapiens 67-77 30445261-4 2019 Considering that fibrinogen stabilized citrate-capped AuNPs against a high-ionic-strength buffer, F-AuNPs efficiently catalyzed the NaBH4-mediated decrease of yellow 4-nitrophenol to colorless 4-aminophenol. 4-aminophenol 193-206 fibrinogen beta chain Homo sapiens 17-27 31008097-3 2019 We found that G-Ro inhibited thrombin-induced platelet aggregation dose-dependently and attenuated the fibronectin-, and fibrinogen-binding to alphaIIb/beta3 through the dephosphorylation of phosphoinositide 3-kinase p85 and Akt, which influence clot retraction, reflecting the intensification of thrombus. ginsenoside Ro 14-18 fibrinogen beta chain Homo sapiens 121-131 30557554-1 2019 The inositol phosphates, InsP5 and InsP6, have recently been identified as binding partners of fibrinogen, which is critically involved in hemostasis by crosslinking activated platelets at sites of vascular injury. Inositol Phosphates 4-23 fibrinogen beta chain Homo sapiens 95-105 30472725-9 2019 Reactive oxygen species (ROS)-derived modifications represent the main post-translational fibrinogen alterations responsible for structural and functional changes. Reactive Oxygen Species 0-23 fibrinogen beta chain Homo sapiens 90-100 30472725-9 2019 Reactive oxygen species (ROS)-derived modifications represent the main post-translational fibrinogen alterations responsible for structural and functional changes. Reactive Oxygen Species 25-28 fibrinogen beta chain Homo sapiens 90-100 29406239-6 2019 RESULTS: Reduced fibrinogen level is observed in 13 out of 30 patients (43.3%) after treatment with L-asparaginase ranging from 25 to 110 mg/dl with means fibrinogen before & after treatment of 252 +- 16.40 mg/dl & 158.97 +- 17.88 mg/dl respectively (p < .0001). Adenosine Monophosphate 174-177 fibrinogen beta chain Homo sapiens 17-27 29406239-6 2019 RESULTS: Reduced fibrinogen level is observed in 13 out of 30 patients (43.3%) after treatment with L-asparaginase ranging from 25 to 110 mg/dl with means fibrinogen before & after treatment of 252 +- 16.40 mg/dl & 158.97 +- 17.88 mg/dl respectively (p < .0001). Adenosine Monophosphate 218-221 fibrinogen beta chain Homo sapiens 17-27 31008097-2 2019 In this study, we evaluated the effect of ginsenoside Ro (G-Ro) on the binding of fibronectin and fibrinogen to alphaIIb/beta3 and clot retraction. ginsenoside Ro 42-56 fibrinogen beta chain Homo sapiens 98-108 31008097-2 2019 In this study, we evaluated the effect of ginsenoside Ro (G-Ro) on the binding of fibronectin and fibrinogen to alphaIIb/beta3 and clot retraction. ginsenoside Ro 58-62 fibrinogen beta chain Homo sapiens 98-108 31008097-5 2019 These results suggest that G-Ro is beneficial, inhibiting fibronectin adhesion, fibrinogen binding, and clot retraction. ginsenoside Ro 27-31 fibrinogen beta chain Homo sapiens 80-90 30056710-9 2019 Compared to untreated gold surfaces, the ultrathin cysteine coating reduced the adsorption of bovine serum albumin by 95% (43 ng/cm2 adsorbed) after 3 h and 90% reduction after 24 h. Similarly, the cysteine self-assembled monolayer reduced the adsorption of fibrinogen as well as human blood by >90%. ultrathin cysteine 41-59 fibrinogen beta chain Homo sapiens 258-268 31011701-1 2019 Abstract: Fibrinogen, involved in coagulation, is a soluble protein composed of two sets of disulfide-bridged Aalpha, Bbeta, and gamma-chains. Disulfides 92-101 fibrinogen beta chain Homo sapiens 10-20 31011701-1 2019 Abstract: Fibrinogen, involved in coagulation, is a soluble protein composed of two sets of disulfide-bridged Aalpha, Bbeta, and gamma-chains. bbeta 118-123 fibrinogen beta chain Homo sapiens 10-20 30733474-0 2019 Molecular interaction of fibrinogen with zeolite nanoparticles. Zeolites 41-48 fibrinogen beta chain Homo sapiens 25-35 30733474-2 2019 Recently, we demonstrated that the fibrinogen highly contributed in the protein corona composition at the surface of zeolite nanoparticles. Zeolites 117-124 fibrinogen beta chain Homo sapiens 35-45 30733474-3 2019 Therefore, understanding the interaction of fibrinogen with zeolite nanoparticles in more details could shed light of their safe applications in medicine. Zeolites 60-67 fibrinogen beta chain Homo sapiens 44-54 30733474-5 2019 The results indicated that fibrinogen has a strong and thermodynamically favorable interaction with zeolite nanoparticles in a non-cooperative manner. Zeolites 100-107 fibrinogen beta chain Homo sapiens 27-37 30733474-6 2019 Additionally, fibrinogen experienced a substantial conformational change in the presence of zeolite nanoparticles through a concentration-dependent manner. Zeolites 92-99 fibrinogen beta chain Homo sapiens 14-24 30733474-7 2019 Simulation results showed that both E- and D-domain of fibrinogen are bound to the EMT zeolite NPs via strong electrostatic interactions, and undergo structural changes leading to exposing normally buried sequences. Zeolites 87-94 fibrinogen beta chain Homo sapiens 55-65 30759794-3 2019 Polymorphisms in the alpha-chain of fibrinogen have been linked to resistance to fibrinolysis in CTEPH patients, and could be responsible for development and disease progression. cteph 97-102 fibrinogen beta chain Homo sapiens 36-46 30056710-9 2019 Compared to untreated gold surfaces, the ultrathin cysteine coating reduced the adsorption of bovine serum albumin by 95% (43 ng/cm2 adsorbed) after 3 h and 90% reduction after 24 h. Similarly, the cysteine self-assembled monolayer reduced the adsorption of fibrinogen as well as human blood by >90%. Cysteine 51-59 fibrinogen beta chain Homo sapiens 258-268 30702627-3 2019 Only the median value for fibrinogen was significantly different in healthy pregnant teenagers (348.9 mg/dL) (interquartile range 21.7) compared with that in healthy adult pregnant patients (359.1 mg/dL) (interquartile range 29.88).Significantly different median blood glucose levels also occurred in the <20; 20-29; 30-39; >40 age groups, but the glucose levels were still within normal limits.Even if there was variability between blood values from one age group to another, the median values for coagulation tests and blood glucose were very close in the healthy teenage pregnant patients compared with the median values of the healthy adult pregnant patients, just before vaginal delivery. Glucose 354-361 fibrinogen beta chain Homo sapiens 26-36 30702627-3 2019 Only the median value for fibrinogen was significantly different in healthy pregnant teenagers (348.9 mg/dL) (interquartile range 21.7) compared with that in healthy adult pregnant patients (359.1 mg/dL) (interquartile range 29.88).Significantly different median blood glucose levels also occurred in the <20; 20-29; 30-39; >40 age groups, but the glucose levels were still within normal limits.Even if there was variability between blood values from one age group to another, the median values for coagulation tests and blood glucose were very close in the healthy teenage pregnant patients compared with the median values of the healthy adult pregnant patients, just before vaginal delivery. Glucose 269-276 fibrinogen beta chain Homo sapiens 26-36 30592962-12 2019 In the presence of Mn2+, escitalopram inhibited the formation of lamellipodia on immobilized fibrinogen. Manganese(2+) 19-23 fibrinogen beta chain Homo sapiens 93-103 30702627-3 2019 Only the median value for fibrinogen was significantly different in healthy pregnant teenagers (348.9 mg/dL) (interquartile range 21.7) compared with that in healthy adult pregnant patients (359.1 mg/dL) (interquartile range 29.88).Significantly different median blood glucose levels also occurred in the <20; 20-29; 30-39; >40 age groups, but the glucose levels were still within normal limits.Even if there was variability between blood values from one age group to another, the median values for coagulation tests and blood glucose were very close in the healthy teenage pregnant patients compared with the median values of the healthy adult pregnant patients, just before vaginal delivery. Glucose 354-361 fibrinogen beta chain Homo sapiens 26-36 30592962-12 2019 In the presence of Mn2+, escitalopram inhibited the formation of lamellipodia on immobilized fibrinogen. Citalopram 25-37 fibrinogen beta chain Homo sapiens 93-103 30326361-3 2019 Adsorption of the proteins fibrinogen, albumin (HSA) and lysozyme on these functionalised plasma polymer surfaces was studied by XPS and quartz crystal microbalance with dissipation (QCM-D). Polymers 97-104 fibrinogen beta chain Homo sapiens 27-37 30828002-5 2019 What we found was that the plasma fibrinogen (FIB) level was 4.63 +- 1.56 g/L before tigecycline treatment, and decreased to 2.92 +- 1.23 g/L during treatment, which was statistically significant (p < 0.001). Tigecycline 85-96 fibrinogen beta chain Homo sapiens 34-44 30828002-5 2019 What we found was that the plasma fibrinogen (FIB) level was 4.63 +- 1.56 g/L before tigecycline treatment, and decreased to 2.92 +- 1.23 g/L during treatment, which was statistically significant (p < 0.001). Tigecycline 85-96 fibrinogen beta chain Homo sapiens 46-49 30828002-7 2019 This study demonstrates that treatment of tigecycline could reduce FIB, prolong aPTT and PT. Tigecycline 42-53 fibrinogen beta chain Homo sapiens 67-70 31561344-1 2019 Hyperlipidemic heart transplant patients who develop cardiac allograft vasculopathy (CAV) benefit from HELP-apheresis (Heparin-induced Extracorporeal LDL Precipitation) which enables drastic lowering of plasma low-density lipoprotein, lipoprotein (a), and fibrinogen. Heparin 119-126 fibrinogen beta chain Homo sapiens 256-266 32821443-5 2019 Fibrinogen levels decreased on the second day of pentoxifylline treatment (p<0.05) and on the last day of AT III treatment (p<0.001). Pentoxifylline 49-63 fibrinogen beta chain Homo sapiens 0-10 30424918-8 2019 Compared to titanium surfaces, the zirconia surface showed increased fibrinogen adsorption, higher levels of total accessible fibrinogen gamma-chain moieties yielding in increased platelet adhesion and activation and consequently thrombogenicity. zirconium oxide 35-43 fibrinogen beta chain Homo sapiens 69-79 30268443-3 2019 Here, we observed the effects of peri-operative dexamethasone on the APR following TKA by trending C-reactive protein (CRP, mg/L) and fibrinogen (mg/dL). Dexamethasone 48-61 fibrinogen beta chain Homo sapiens 134-144 30268443-9 2019 A significant decrease in fibrinogen in patients receiving dexamethasone was seen on POD2 (460.0 vs 530.2). Dexamethasone 59-72 fibrinogen beta chain Homo sapiens 26-36 30268443-10 2019 There was an increase in fibrinogen within the dexamethasone cohort at the 2-week visit (535.4 vs 488.9). Dexamethasone 47-60 fibrinogen beta chain Homo sapiens 25-35 31336458-1 2019 BACKGROUND & AIM: Fibrinogen has been implicated as a cause of atherosclerosis and its complications in patients with type 2 DM. Adenosine Monophosphate 12-15 fibrinogen beta chain Homo sapiens 22-32 30719143-5 2019 Results: Our results indicate that pretreatment plasma fibrinogen is a prognostic factor in urological cancers (OS: HR=2.21, 95% CI=1.91-2.57, P<0.001, CSS: HR=2.67, 95% CI=2.23-3.19, P<0.001). thiocysteine 155-158 fibrinogen beta chain Homo sapiens 55-65 30719143-9 2019 Conclusions: These results show that high pretreatment plasma fibrinogen levels can predict poorer OS and CSS in patients with urological cancers. Osmium 99-101 fibrinogen beta chain Homo sapiens 62-72 30719143-9 2019 Conclusions: These results show that high pretreatment plasma fibrinogen levels can predict poorer OS and CSS in patients with urological cancers. thiocysteine 106-109 fibrinogen beta chain Homo sapiens 62-72 32821443-7 2019 Conclusion: Both ATIII and pentoxifylline treatments had positive effects on fibrinogen, FDP, D-Dimer, AT III activity and DIC scores in patients with Gram-negative sepsis who developed DIC. Pentoxifylline 27-41 fibrinogen beta chain Homo sapiens 77-87 31168199-1 2018 - The aim was to examine whether the postprocedural change in C-reactive protein (CRP) and fibrinogen levels was associated with the extent of periprocedural arterial injury caused by endovascular treatment (EVT). EVT 208-211 fibrinogen beta chain Homo sapiens 91-101 30512152-6 2018 Genetic analysis showed that g.7476 G>A heterozygous missense mutation in exon 8 of FGG gene resulted in mutations in arginine at position 275 of fibrinogen gamma D domain to histidine (Arg275His). Arginine 121-129 fibrinogen beta chain Homo sapiens 149-159 30512152-6 2018 Genetic analysis showed that g.7476 G>A heterozygous missense mutation in exon 8 of FGG gene resulted in mutations in arginine at position 275 of fibrinogen gamma D domain to histidine (Arg275His). Histidine 178-187 fibrinogen beta chain Homo sapiens 149-159 31184628-9 2019 CONCLUSION: The study confirms the impact of mexidol on the fluidity of blood during the acute cerebral ischemia and shows its efficacy in reducing blood viscosity, decreasing the level of hematocrit and fibrinogen, increasing the deformability of erythrocytes. emoxypine succinate 45-52 fibrinogen beta chain Homo sapiens 204-214 31168199-6 2018 There was significant increase in plasma CRP and fibrinogen levels 48 hours following EVT (p<0.001). EVT 86-89 fibrinogen beta chain Homo sapiens 49-59 30343500-8 2018 Dilution with saline and albumin induced a profibrinolytic state and further deteriorated the impaired hemostatic potential of rivaroxaban-anticoagulated blood, even after PCC and fibrinogen support. Sodium Chloride 14-20 fibrinogen beta chain Homo sapiens 180-190 30114949-4 2018 In this study, fibrin clot characteristic differences at 3 glucose concentrations were analyzed to determine the effects of glucose concentration on fibrinogen glycation and fibrin clot morphology using confocal microscopy, glycation quantification, molecular simulations, and image processing methods. Glucose 124-131 fibrinogen beta chain Homo sapiens 149-159 30114949-6 2018 Our experimental and molecular simulation results consistently show an increased glucose adsorption by fibrinogen with increased glucose concentration. Glucose 81-88 fibrinogen beta chain Homo sapiens 103-113 30114949-6 2018 Our experimental and molecular simulation results consistently show an increased glucose adsorption by fibrinogen with increased glucose concentration. Glucose 129-136 fibrinogen beta chain Homo sapiens 103-113 30243119-0 2018 Study on the oxidation of fibrinogen using Fe3O4 magnetic nanoparticles and its influence to the formation of fibrin. ferryl iron 43-48 fibrinogen beta chain Homo sapiens 26-36 30243119-2 2018 In this work, H2O2 and H2O2-Fe3O4 magnetic nanoparticles were used as two reactive oxygen species to study the oxidative stress for the structure and polymerization behaviour of fibrinogen molecules. Hydrogen Peroxide 14-18 fibrinogen beta chain Homo sapiens 178-188 30243119-2 2018 In this work, H2O2 and H2O2-Fe3O4 magnetic nanoparticles were used as two reactive oxygen species to study the oxidative stress for the structure and polymerization behaviour of fibrinogen molecules. Hydrogen Peroxide 23-27 fibrinogen beta chain Homo sapiens 178-188 30243119-2 2018 In this work, H2O2 and H2O2-Fe3O4 magnetic nanoparticles were used as two reactive oxygen species to study the oxidative stress for the structure and polymerization behaviour of fibrinogen molecules. ferryl iron 28-33 fibrinogen beta chain Homo sapiens 178-188 30243119-2 2018 In this work, H2O2 and H2O2-Fe3O4 magnetic nanoparticles were used as two reactive oxygen species to study the oxidative stress for the structure and polymerization behaviour of fibrinogen molecules. Reactive Oxygen Species 74-97 fibrinogen beta chain Homo sapiens 178-188 30412834-10 2018 CONCLUSIONS: Fibrinogen gammaCys165Arg mutations cause damage to the interchain disulfide bonds of fibrinogen and hinder fibrinogen secretion, possibly explaining the pathological mechanism associated with congenital hypofibrinogenemia. Disulfides 80-89 fibrinogen beta chain Homo sapiens 13-23 30412834-10 2018 CONCLUSIONS: Fibrinogen gammaCys165Arg mutations cause damage to the interchain disulfide bonds of fibrinogen and hinder fibrinogen secretion, possibly explaining the pathological mechanism associated with congenital hypofibrinogenemia. Disulfides 80-89 fibrinogen beta chain Homo sapiens 99-109 30238410-9 2018 Plasma levels of C reactive protein and fibrinogen showed positive correlation with myeloperoxidase, malondialdehyde, carbonyl groups and PHASES score and negative correlation with catalase. Malondialdehyde 101-116 fibrinogen beta chain Homo sapiens 40-50 30582601-10 2018 The effectiveness of these optimized protocols is demonstrated here using TDI-2760, a recently identified Abeta-fibrinogen interaction inhibitor. tdi-2760 74-82 fibrinogen beta chain Homo sapiens 112-122 30354162-3 2018 Here, we use single-molecule mapping by accumulated probe trajectories and complementary atomic force microscopy to shed light on the dynamic of in situ assembly of human plasma fibrinogen (HPF) adsorbed on nanostructured polybutene-1 (PB-1) and nanostructured polyethylene (PE) surfaces. Polyethylene 261-273 fibrinogen beta chain Homo sapiens 178-188 30354162-3 2018 Here, we use single-molecule mapping by accumulated probe trajectories and complementary atomic force microscopy to shed light on the dynamic of in situ assembly of human plasma fibrinogen (HPF) adsorbed on nanostructured polybutene-1 (PB-1) and nanostructured polyethylene (PE) surfaces. Polyethylene 275-277 fibrinogen beta chain Homo sapiens 178-188 30216076-1 2018 In the present study, we investigated the surface reorganization behaviors and adsorption conformations of fibrinogen on the surface of polyrotaxanes containing different amounts of alpha-cyclodextrin (alpha-CD) by using surface-sensitive vibrational spectroscopy sum frequency generation (SFG). Rotaxanes 136-149 fibrinogen beta chain Homo sapiens 107-117 29865859-11 2018 In conclusion, PDAC was associated with increased fibrinogen and FVIII. pdac 15-19 fibrinogen beta chain Homo sapiens 50-60 30467540-0 2018 Analysis of Interaction Between Interfacial Structure and Fibrinogen at Blood-Compatible Polymer/Water Interface. Water 97-102 fibrinogen beta chain Homo sapiens 58-68 30467540-7 2018 The non-adsorption of FNG into the water rich domains was also clarified through topographic and phase image analyses. Water 35-40 fibrinogen beta chain Homo sapiens 22-25 30467540-8 2018 Furthermore, the FNG molecules adsorbed on the surface of PMEA were easily desorbed, even in the polymer-rich domains. adefovir 58-62 fibrinogen beta chain Homo sapiens 17-20 30467540-8 2018 Furthermore, the FNG molecules adsorbed on the surface of PMEA were easily desorbed, even in the polymer-rich domains. Polymers 97-104 fibrinogen beta chain Homo sapiens 17-20 30467540-9 2018 Water molecules in the water-rich domains are anticipated to be the dominant factor in preventing FNG adsorption and thrombogenesis on a PMEA interface. Water 0-5 fibrinogen beta chain Homo sapiens 98-101 30467540-9 2018 Water molecules in the water-rich domains are anticipated to be the dominant factor in preventing FNG adsorption and thrombogenesis on a PMEA interface. Water 23-28 fibrinogen beta chain Homo sapiens 98-101 30216076-1 2018 In the present study, we investigated the surface reorganization behaviors and adsorption conformations of fibrinogen on the surface of polyrotaxanes containing different amounts of alpha-cyclodextrin (alpha-CD) by using surface-sensitive vibrational spectroscopy sum frequency generation (SFG). alpha-cyclodextrin 182-200 fibrinogen beta chain Homo sapiens 107-117 30216076-1 2018 In the present study, we investigated the surface reorganization behaviors and adsorption conformations of fibrinogen on the surface of polyrotaxanes containing different amounts of alpha-cyclodextrin (alpha-CD) by using surface-sensitive vibrational spectroscopy sum frequency generation (SFG). alpha-cyclodextrin 202-210 fibrinogen beta chain Homo sapiens 107-117 30216076-2 2018 For comparison, behaviors of the surface restructuring and fibrinogen adsorption on the random copolymers containing similar terminal groups were also investigated. copolymers 95-105 fibrinogen beta chain Homo sapiens 59-69 30216076-3 2018 It was found that larger amounts of BMA moieties of polyrotaxanes form ordered surface structures after immersion in water for 48 h. Furthermore, the polyrotaxane surfaces exhibit a much higher capability of fibrinogen adsorption than the random copolymer surfaces. bma 36-39 fibrinogen beta chain Homo sapiens 208-218 30216076-3 2018 It was found that larger amounts of BMA moieties of polyrotaxanes form ordered surface structures after immersion in water for 48 h. Furthermore, the polyrotaxane surfaces exhibit a much higher capability of fibrinogen adsorption than the random copolymer surfaces. Rotaxanes 52-65 fibrinogen beta chain Homo sapiens 208-218 30216076-3 2018 It was found that larger amounts of BMA moieties of polyrotaxanes form ordered surface structures after immersion in water for 48 h. Furthermore, the polyrotaxane surfaces exhibit a much higher capability of fibrinogen adsorption than the random copolymer surfaces. polyrotaxane 52-64 fibrinogen beta chain Homo sapiens 208-218 30216076-4 2018 The water-induced surface restructuring of the polyrotaxane films slightly affects the adsorption structure of the fibrinogen molecules. Water 4-9 fibrinogen beta chain Homo sapiens 115-125 30216076-4 2018 The water-induced surface restructuring of the polyrotaxane films slightly affects the adsorption structure of the fibrinogen molecules. polyrotaxane 47-59 fibrinogen beta chain Homo sapiens 115-125 30076961-9 2018 Unexpectedly, FSAP-treated fibrinogen or plasma exhibited a significantly faster tPA-driven lysis, which correlated exclusively with cleavage of fibrinogen and not with activation of plasminogen activators. Tetradecanoylphorbol Acetate 81-84 fibrinogen beta chain Homo sapiens 27-37 30076961-9 2018 Unexpectedly, FSAP-treated fibrinogen or plasma exhibited a significantly faster tPA-driven lysis, which correlated exclusively with cleavage of fibrinogen and not with activation of plasminogen activators. Tetradecanoylphorbol Acetate 81-84 fibrinogen beta chain Homo sapiens 145-155 29869737-0 2018 Abnormal fibrinogen with an Aalpha 16Arg Cys substitution is associated with multiple cerebral infarctions. Cysteine 43-46 fibrinogen beta chain Homo sapiens 9-19 29869737-5 2018 The polymerization of the purified fibrinogen was strongly impaired in the presence of calcium. Calcium 87-94 fibrinogen beta chain Homo sapiens 35-45 29931617-6 2018 This pattern of coagulation kinetic response was interpreted as copper mediated fibrinogen dysfunction, perhaps via oxidation of key fibrinogen disulfide bridges. Copper 64-70 fibrinogen beta chain Homo sapiens 80-90 29931617-6 2018 This pattern of coagulation kinetic response was interpreted as copper mediated fibrinogen dysfunction, perhaps via oxidation of key fibrinogen disulfide bridges. Copper 64-70 fibrinogen beta chain Homo sapiens 133-143 29931617-6 2018 This pattern of coagulation kinetic response was interpreted as copper mediated fibrinogen dysfunction, perhaps via oxidation of key fibrinogen disulfide bridges. Disulfides 144-153 fibrinogen beta chain Homo sapiens 80-90 29931617-6 2018 This pattern of coagulation kinetic response was interpreted as copper mediated fibrinogen dysfunction, perhaps via oxidation of key fibrinogen disulfide bridges. Disulfides 144-153 fibrinogen beta chain Homo sapiens 133-143 30193463-7 2018 This was done by using a model NO-releasing polymer film system, plasticized poly(vinyl chloride) (PVC) and S-nitrosoglutathione, to examine how NO-mediated pre-adsorbed Fb, a major blood serum protein that initiates the blood clotting cascade, affects platelet adhesion and activation. S-Nitrosoglutathione 108-128 fibrinogen beta chain Homo sapiens 170-172 29982129-8 2018 The largest short- and long-term associations were observed for ferritin in response to nitrogen dioxide exposure (1.4%, 95% confidence interval [CI] 0.3-2.5) and fibrinogen exposed to particles < 2.5 mum (3.4%, 95% CI 3.0-3.8), respectively. Nitrogen Dioxide 88-104 fibrinogen beta chain Homo sapiens 163-173 30193463-0 2018 Nitric oxide-mediated fibrinogen deposition prevents platelet adhesion and activation. Nitric Oxide 0-12 fibrinogen beta chain Homo sapiens 22-32 30193463-8 2018 The NO-releasing polymer films were found to increase Fb adsorption, but decrease platelet adhesion and activation on the surface when compared to plasticized PVC control films. Polymers 17-24 fibrinogen beta chain Homo sapiens 54-56 30193463-9 2018 Further, to eliminate the effects of NO on platelets, NO-releasing polymer films were first exposed to Fb and then incubated until all NO was released. Polymers 67-74 fibrinogen beta chain Homo sapiens 103-105 30019168-5 2018 In a therapeutic approach, we now tested ERRgamma inverse agonist GSK5182 as regulator of fibrinogen levels in mouse hyperfibrinogenemia caused by diet-induced obesity and in mouse hepatocytes. GSK5182 66-73 fibrinogen beta chain Homo sapiens 90-100 30019168-6 2018 ACEA, a CB1R agonist, up-regulated transcription of mouse fibrinogen via induction of ERRgamma, whereas knockdown of ERRgamma attenuated the effect of ACEA (10 microM) on fibrinogen expression in AML12 mouse hepatocytes. arachidonyl-2-chloroethylamide 0-4 fibrinogen beta chain Homo sapiens 58-68 30019168-6 2018 ACEA, a CB1R agonist, up-regulated transcription of mouse fibrinogen via induction of ERRgamma, whereas knockdown of ERRgamma attenuated the effect of ACEA (10 microM) on fibrinogen expression in AML12 mouse hepatocytes. arachidonyl-2-chloroethylamide 151-155 fibrinogen beta chain Homo sapiens 171-181 29999213-9 2018 All patients with thrombocytopenia or hypofibrinogenemia reached a normal platelet count and a normal fibrinogen level within 3 to 4 weeks after sirolimus treatment. Sirolimus 145-154 fibrinogen beta chain Homo sapiens 42-52 30019168-10 2018 Finally, GSK5182 (40 mg/kg) strongly inhibits the ACEA (10 mg/kg) or HFD-mediated induction of fibrinogen level in mice. GSK5182 9-16 fibrinogen beta chain Homo sapiens 95-105 30019168-10 2018 Finally, GSK5182 (40 mg/kg) strongly inhibits the ACEA (10 mg/kg) or HFD-mediated induction of fibrinogen level in mice. arachidonyl-2-chloroethylamide 50-54 fibrinogen beta chain Homo sapiens 95-105 30239013-6 2018 Moreover, comparison between five PSf membranes showed that the number of adherent platelets and neutrophil ROS production increased with increasing fibrinogen adsorption. Reactive Oxygen Species 108-111 fibrinogen beta chain Homo sapiens 149-159 30239013-0 2018 Biocompatibility of Polysulfone Hemodialysis Membranes and Its Mechanisms: Involvement of Fibrinogen and Its Integrin Receptors in Activation of Platelets and Neutrophils. polysulfone P 1700 20-31 fibrinogen beta chain Homo sapiens 90-100 30019251-0 2018 Fibrinogen binding-dependent cytotoxicity and degradation of single-walled carbon nanotubes. Carbon 75-81 fibrinogen beta chain Homo sapiens 0-10 30089611-7 2018 SDS-PAGE revealed three major bands with considerably increased intensity in BV leaflets that were identified as plasminogen and fibrinogen gamma chain (100 kDa), and fibrinogen beta chain (50 and 37 kDa) by mass analysis. Sodium Dodecyl Sulfate 0-3 fibrinogen beta chain Homo sapiens 129-139 30089611-7 2018 SDS-PAGE revealed three major bands with considerably increased intensity in BV leaflets that were identified as plasminogen and fibrinogen gamma chain (100 kDa), and fibrinogen beta chain (50 and 37 kDa) by mass analysis. Sodium Dodecyl Sulfate 0-3 fibrinogen beta chain Homo sapiens 167-188 30019251-5 2018 On the other hand, although SWCNTs and fibrinogen-preincubated SWCNTs were resistant to biodegradation in resting macrophages, both naked and fibrinogen-coated SWCNTs could be effectively and similarly degraded through myeloperoxidase (MPO) and peroxynitrite (ONOO-)-dependent pathways in activated macrophages, where NADPH oxidase played a determinant role in the biodegradation process. oxido nitrite 260-265 fibrinogen beta chain Homo sapiens 39-49 30019251-2 2018 In this work, we investigated the effects of human fibrinogen-surface coatings on the biodegradation and cytotoxicity of carboxylated single-walled carbon nanotubes (SWCNTs). Carbon 148-154 fibrinogen beta chain Homo sapiens 51-61 30019251-5 2018 On the other hand, although SWCNTs and fibrinogen-preincubated SWCNTs were resistant to biodegradation in resting macrophages, both naked and fibrinogen-coated SWCNTs could be effectively and similarly degraded through myeloperoxidase (MPO) and peroxynitrite (ONOO-)-dependent pathways in activated macrophages, where NADPH oxidase played a determinant role in the biodegradation process. oxido nitrite 260-265 fibrinogen beta chain Homo sapiens 142-152 30019251-5 2018 On the other hand, although SWCNTs and fibrinogen-preincubated SWCNTs were resistant to biodegradation in resting macrophages, both naked and fibrinogen-coated SWCNTs could be effectively and similarly degraded through myeloperoxidase (MPO) and peroxynitrite (ONOO-)-dependent pathways in activated macrophages, where NADPH oxidase played a determinant role in the biodegradation process. Peroxynitrous Acid 245-258 fibrinogen beta chain Homo sapiens 39-49 30019251-5 2018 On the other hand, although SWCNTs and fibrinogen-preincubated SWCNTs were resistant to biodegradation in resting macrophages, both naked and fibrinogen-coated SWCNTs could be effectively and similarly degraded through myeloperoxidase (MPO) and peroxynitrite (ONOO-)-dependent pathways in activated macrophages, where NADPH oxidase played a determinant role in the biodegradation process. Peroxynitrous Acid 245-258 fibrinogen beta chain Homo sapiens 142-152 29932420-6 2018 Cell adhesion assays and molecular dynamics simulations demonstrate that cleavage of the disulfide induces long-range allosteric effects within the betaI-domain, mainly affecting the metal-binding sites, that results in release of fibrinogen. Disulfides 89-98 fibrinogen beta chain Homo sapiens 231-241 29661301-5 2018 Additionally, antifouling properties of carboxybetaine functionalized dextran micelles were much better than that of unmodified dextran for fibrinogen and lysozyme as tested by ITC. carboxybetaine 40-54 fibrinogen beta chain Homo sapiens 140-150 29661301-5 2018 Additionally, antifouling properties of carboxybetaine functionalized dextran micelles were much better than that of unmodified dextran for fibrinogen and lysozyme as tested by ITC. Dextrans 70-77 fibrinogen beta chain Homo sapiens 140-150 29661301-5 2018 Additionally, antifouling properties of carboxybetaine functionalized dextran micelles were much better than that of unmodified dextran for fibrinogen and lysozyme as tested by ITC. Dextrans 128-135 fibrinogen beta chain Homo sapiens 140-150 29698786-4 2018 The ultrastructure of individual fibrinogen molecules was studied after heating or extended contact with the highly oriented pyrolytic graphite surface (HOPG) modified with oligoglycine-hydrocarbon graphite modifier (GM). Graphite 135-143 fibrinogen beta chain Homo sapiens 33-43 29698786-4 2018 The ultrastructure of individual fibrinogen molecules was studied after heating or extended contact with the highly oriented pyrolytic graphite surface (HOPG) modified with oligoglycine-hydrocarbon graphite modifier (GM). oligoglycine-hydrocarbon 173-197 fibrinogen beta chain Homo sapiens 33-43 29698786-4 2018 The ultrastructure of individual fibrinogen molecules was studied after heating or extended contact with the highly oriented pyrolytic graphite surface (HOPG) modified with oligoglycine-hydrocarbon graphite modifier (GM). Graphite 198-206 fibrinogen beta chain Homo sapiens 33-43 29698786-4 2018 The ultrastructure of individual fibrinogen molecules was studied after heating or extended contact with the highly oriented pyrolytic graphite surface (HOPG) modified with oligoglycine-hydrocarbon graphite modifier (GM). gm 217-219 fibrinogen beta chain Homo sapiens 33-43 29698786-6 2018 Fibrinogen unfolded by the extended (10 min) incubation on GM-HOPG surface in water revealed a different morphology. Water 78-83 fibrinogen beta chain Homo sapiens 0-10 29698786-7 2018 It contained fibrillar structures only, and their organization reflected the initial native structure of fibrinogen: typically, six polypeptide chains connected by multiple disulfide bonds were seen. Disulfides 173-182 fibrinogen beta chain Homo sapiens 105-115 29698786-9 2018 The obtained results provide better understanding of fibrinogen unfolding induced by different factors and are important for improvement of biomedical applications, such as fibrinogen-based protein matrixes and carbon-based biomaterials. Carbon 211-217 fibrinogen beta chain Homo sapiens 53-63 29189568-11 2018 Furthermore, the levels of the prethrombosis-state molecular markers GMP-140, fibrinogen, fibrin degradation products, and D-dimer were higher in the TXA group than in the Placebo group, although the differences were not significant (P > 0.05). Tranexamic Acid 150-153 fibrinogen beta chain Homo sapiens 78-88 29906086-8 2018 The ability to successfully conduct electrochemical measurements in biofouling solutions via a unique biosieving-like mechanism is demonstrated by exposure of the unique 3D bicontinuous nanoporous platinum-based electrode to fibrinogen in phosphate buffer and in a solution containing red blood cells. Platinum 197-205 fibrinogen beta chain Homo sapiens 225-235 29906086-8 2018 The ability to successfully conduct electrochemical measurements in biofouling solutions via a unique biosieving-like mechanism is demonstrated by exposure of the unique 3D bicontinuous nanoporous platinum-based electrode to fibrinogen in phosphate buffer and in a solution containing red blood cells. Phosphates 239-248 fibrinogen beta chain Homo sapiens 225-235 29932420-6 2018 Cell adhesion assays and molecular dynamics simulations demonstrate that cleavage of the disulfide induces long-range allosteric effects within the betaI-domain, mainly affecting the metal-binding sites, that results in release of fibrinogen. Metals 183-188 fibrinogen beta chain Homo sapiens 231-241 30701900-16 2018 At the same time, during high volume DFPP should be careful when initially level of fibrinogen is low. dfpp 37-41 fibrinogen beta chain Homo sapiens 84-94 29880012-6 2018 Synthesis rates of albumin and fibrinogen were estimated by the flooding technique using deuterium-labeled phenylalanine. Deuterium 89-98 fibrinogen beta chain Homo sapiens 31-41 29565228-0 2018 Impact of tigecycline versus imipenem-cilastatin on fibrinogen levels following cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC): a randomized-controlled study. Cilastatin 38-48 fibrinogen beta chain Homo sapiens 52-62 29565228-1 2018 The aim of this prospective, randomized study was to compare the effects of tigecycline and imipenem-cilastatin on fibrinogen levels in patients undergoing cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). Tigecycline 76-87 fibrinogen beta chain Homo sapiens 115-125 29565228-1 2018 The aim of this prospective, randomized study was to compare the effects of tigecycline and imipenem-cilastatin on fibrinogen levels in patients undergoing cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). Cilastatin, Imipenem Drug Combination 92-111 fibrinogen beta chain Homo sapiens 115-125 29565228-6 2018 In conclusion, compared to imipenem-cilastatin, tigecycline was associated with a significant decrease in fibrinogen levels, following CRS and HIPEC. Tigecycline 48-59 fibrinogen beta chain Homo sapiens 106-116 29377555-5 2018 To enhance the biocompatibility the surface of palmitoyl-hyaluronan was roughened by freeze drying and treated by different cell adhesive proteins (fibronectin, fibrinogen, laminin, methacrylated gelatin and collagen IV). palmitoyl-hyaluronan 47-67 fibrinogen beta chain Homo sapiens 161-171 29709181-2 2018 With this technique, we identify the amide I" vibrational modes of the antiparallel beta-sheets and turns of fibrinogen. Amides 37-42 fibrinogen beta chain Homo sapiens 109-119 29459207-3 2018 We present the design of a group of sulfated benzofuran dimers that display heparin-binding site-dependent partial allosteric inhibition of thrombin against fibrinogen (DeltaY = 55-75%), the first time that a small molecule (MW < 800) has been found to thwart macromolecular cleavage by a monomeric protease in a controlled manner. benzofuran 45-55 fibrinogen beta chain Homo sapiens 157-167 29747114-5 2018 RESULTS: After the first DFPP session, median levels of high molecular-weight proteins (fibrinogen, FV, FVIII, FXI, FXIII, von Willebrand factors and alpha2-MG) decreased significantly to <50% of baseline values, whereas levels of low molecular-weight factors (<100 kDa) were not significantly modified, except for protein S and TFPI. dfpp 25-29 fibrinogen beta chain Homo sapiens 88-98 29709171-0 2018 Bovine Serum Albumin and Fibrinogen Adsorption at the 316L Stainless Steel/Aqueous Interface. Stainless Steel 59-74 fibrinogen beta chain Homo sapiens 25-35 29709171-3 2018 Although the preadsorption of BSA to an untreated stainless steel surface did slightly decrease the amount of fibrinogen adsorbed initially, it had no inhibiting effect if a solution containing solely fibrinogen subsequently flowed through. Stainless Steel 50-65 fibrinogen beta chain Homo sapiens 110-120 29709171-4 2018 In contrast, the SDS-treated surface yielded both an increased BSA adsorption and consistently decreased fibrinogen adsorption. Sodium Dodecyl Sulfate 17-20 fibrinogen beta chain Homo sapiens 105-115 29774108-3 2018 Results: Pretreatment Fibrinogen serum concentrations, NLRs and PLRs were highest in patients with TCs and advanced tumor stages. Technetium 99-102 fibrinogen beta chain Homo sapiens 22-32 29774108-4 2018 High pretreatment Fibrinogen serum concentration (>=452.5 mg/dL) was significantly associated with worse cause specific survival (CSS; p = 0.001) and freedom from recurrence (FFR; p = 0.043), high NLR (>=4.0) with worse FFR (p = 0.008), and high PLR (>=136.5) with worse CSS (p = 0.032). thiocysteine 133-136 fibrinogen beta chain Homo sapiens 18-28 29774108-4 2018 High pretreatment Fibrinogen serum concentration (>=452.5 mg/dL) was significantly associated with worse cause specific survival (CSS; p = 0.001) and freedom from recurrence (FFR; p = 0.043), high NLR (>=4.0) with worse FFR (p = 0.008), and high PLR (>=136.5) with worse CSS (p = 0.032). thiocysteine 280-283 fibrinogen beta chain Homo sapiens 18-28 29616243-5 2018 Our results revealed that glucose and cholesterol had the capacity to induce substantial changes in the binding site of fibrinogen to the surface of NPs. Glucose 26-33 fibrinogen beta chain Homo sapiens 120-130 29616243-5 2018 Our results revealed that glucose and cholesterol had the capacity to induce substantial changes in the binding site of fibrinogen to the surface of NPs. Cholesterol 38-49 fibrinogen beta chain Homo sapiens 120-130 29662311-4 2018 Results: Atomic force microscopy-based force spectroscopy measurements showed a significant decrease both on the fibrinogen-erythrocyte binding force and on its frequency for fibrinogen with the D97E mutation, indicating that the corresponding arginine-glycine-aspartate sequence (residues 95-97) is involved in this interaction, and supporting that the fibrinogen receptor on erythrocytes has a beta3 subunit. Arginine 244-252 fibrinogen beta chain Homo sapiens 113-123 29662311-4 2018 Results: Atomic force microscopy-based force spectroscopy measurements showed a significant decrease both on the fibrinogen-erythrocyte binding force and on its frequency for fibrinogen with the D97E mutation, indicating that the corresponding arginine-glycine-aspartate sequence (residues 95-97) is involved in this interaction, and supporting that the fibrinogen receptor on erythrocytes has a beta3 subunit. Arginine 244-252 fibrinogen beta chain Homo sapiens 175-185 29662311-4 2018 Results: Atomic force microscopy-based force spectroscopy measurements showed a significant decrease both on the fibrinogen-erythrocyte binding force and on its frequency for fibrinogen with the D97E mutation, indicating that the corresponding arginine-glycine-aspartate sequence (residues 95-97) is involved in this interaction, and supporting that the fibrinogen receptor on erythrocytes has a beta3 subunit. Arginine 244-252 fibrinogen beta chain Homo sapiens 175-185 29662311-4 2018 Results: Atomic force microscopy-based force spectroscopy measurements showed a significant decrease both on the fibrinogen-erythrocyte binding force and on its frequency for fibrinogen with the D97E mutation, indicating that the corresponding arginine-glycine-aspartate sequence (residues 95-97) is involved in this interaction, and supporting that the fibrinogen receptor on erythrocytes has a beta3 subunit. Glycine 253-260 fibrinogen beta chain Homo sapiens 113-123 29662311-4 2018 Results: Atomic force microscopy-based force spectroscopy measurements showed a significant decrease both on the fibrinogen-erythrocyte binding force and on its frequency for fibrinogen with the D97E mutation, indicating that the corresponding arginine-glycine-aspartate sequence (residues 95-97) is involved in this interaction, and supporting that the fibrinogen receptor on erythrocytes has a beta3 subunit. Glycine 253-260 fibrinogen beta chain Homo sapiens 175-185 29662311-4 2018 Results: Atomic force microscopy-based force spectroscopy measurements showed a significant decrease both on the fibrinogen-erythrocyte binding force and on its frequency for fibrinogen with the D97E mutation, indicating that the corresponding arginine-glycine-aspartate sequence (residues 95-97) is involved in this interaction, and supporting that the fibrinogen receptor on erythrocytes has a beta3 subunit. Glycine 253-260 fibrinogen beta chain Homo sapiens 175-185 29662311-4 2018 Results: Atomic force microscopy-based force spectroscopy measurements showed a significant decrease both on the fibrinogen-erythrocyte binding force and on its frequency for fibrinogen with the D97E mutation, indicating that the corresponding arginine-glycine-aspartate sequence (residues 95-97) is involved in this interaction, and supporting that the fibrinogen receptor on erythrocytes has a beta3 subunit. Aspartic Acid 261-270 fibrinogen beta chain Homo sapiens 113-123 29662311-4 2018 Results: Atomic force microscopy-based force spectroscopy measurements showed a significant decrease both on the fibrinogen-erythrocyte binding force and on its frequency for fibrinogen with the D97E mutation, indicating that the corresponding arginine-glycine-aspartate sequence (residues 95-97) is involved in this interaction, and supporting that the fibrinogen receptor on erythrocytes has a beta3 subunit. Aspartic Acid 261-270 fibrinogen beta chain Homo sapiens 175-185 29662311-4 2018 Results: Atomic force microscopy-based force spectroscopy measurements showed a significant decrease both on the fibrinogen-erythrocyte binding force and on its frequency for fibrinogen with the D97E mutation, indicating that the corresponding arginine-glycine-aspartate sequence (residues 95-97) is involved in this interaction, and supporting that the fibrinogen receptor on erythrocytes has a beta3 subunit. Aspartic Acid 261-270 fibrinogen beta chain Homo sapiens 175-185 29266801-8 2018 The most citrulline-specific antibodies in the sputum of at-risk subjects were those to fibrinogen, vimentin, and peptides of fibrinogen A and apolipoprotein A1. Citrulline 9-19 fibrinogen beta chain Homo sapiens 88-98 29923974-7 2018 Similarly, from our result, it was found that high plasm fibrinogen was also significantly associated with worse OS in PC (HR = 1.56; 95% CI: 1.13-2.15; P < .01). Osmium 113-115 fibrinogen beta chain Homo sapiens 57-67 29790645-2 2018 FIBPT-d method overestimates fibrinogen in rivaroxaban and low molecular weight heparin samples. Rivaroxaban 43-54 fibrinogen beta chain Homo sapiens 29-39 29790645-2 2018 FIBPT-d method overestimates fibrinogen in rivaroxaban and low molecular weight heparin samples. Heparin 80-87 fibrinogen beta chain Homo sapiens 29-39 33445317-4 2018 The biocompatibility evaluation results indicated that the SEMA4D-heparin-modified surfaces displayed less platelet adhesion and activation, prolonged activated partial thromboplastin time (APTT), prothrombin time (PT) and thrombin time (TT) and reduced fibrinogen gamma chain (FGG) exposure and fibrinogen adhesion. Heparin 66-73 fibrinogen beta chain Homo sapiens 254-264 29715224-4 2018 The addition of tranexamic acid during a surgical procedure may mitigate the coagulopathy by impeding the derangement in D-dimer and fibrinogen kinetics. Tranexamic Acid 16-31 fibrinogen beta chain Homo sapiens 133-143 29715224-11 2018 The consumption of fibrinogen was 98.4 +- 42.6 mg/dL in the control cohort but was reduced in the tranexamic acid cohort to 60.6 +- 35.1 mg/dL (p = 0.004). Tranexamic Acid 98-113 fibrinogen beta chain Homo sapiens 19-29 29715224-13 2018 Monitoring of D-dimer and fibrinogen during spinal surgery suggests that tranexamic acid impedes the fibrinolytic pathway by decreasing consumption of fibrinogen and clot dissolution as evidenced by the reduced formation of D-dimer. Tranexamic Acid 73-88 fibrinogen beta chain Homo sapiens 26-36 29715224-13 2018 Monitoring of D-dimer and fibrinogen during spinal surgery suggests that tranexamic acid impedes the fibrinolytic pathway by decreasing consumption of fibrinogen and clot dissolution as evidenced by the reduced formation of D-dimer. Tranexamic Acid 73-88 fibrinogen beta chain Homo sapiens 151-161 29715236-2 2018 : "Effect of Tranexamic Acid on Blood Loss, D-Dimer, and Fibrinogen Kinetics in Adult Spinal Deformity Surgery". Tranexamic Acid 13-28 fibrinogen beta chain Homo sapiens 57-67 29564685-9 2018 Fibrinogen (FBG) activity (Clauss) rose with time from 0 to 2 h and 12 h, which significantly slowed down Clot Lysis Potential as determined by an in vitro method with exogenous t-PA. t-pa 178-182 fibrinogen beta chain Homo sapiens 0-10 29459207-3 2018 We present the design of a group of sulfated benzofuran dimers that display heparin-binding site-dependent partial allosteric inhibition of thrombin against fibrinogen (DeltaY = 55-75%), the first time that a small molecule (MW < 800) has been found to thwart macromolecular cleavage by a monomeric protease in a controlled manner. Heparin 76-83 fibrinogen beta chain Homo sapiens 157-167 29618528-0 2018 Evolution and mechanics of mixed phospholipid fibrinogen monolayers. Phospholipids 33-45 fibrinogen beta chain Homo sapiens 46-56 29622876-1 2018 The current study was carried out to evaluate the pharmacological properties of cupincin- A novel cupin domain containing metalloprotease with limited proteolysis from rice bran on blood coagulation and hydrolysis of human fibrinogen. cupincin 80-88 fibrinogen beta chain Homo sapiens 223-233 29622876-2 2018 Cupincin preferentially hydrolyzed the Aalpha chain of fibrinogen and then the Bbeta-chain, but not the gamma-chain. cupincin 0-8 fibrinogen beta chain Homo sapiens 55-65 29622876-5 2018 Sonoclot analysis indicated that cupincin cleaved fibrinogen of whole citrated blood. cupincin 33-41 fibrinogen beta chain Homo sapiens 50-60 29618528-5 2018 By contrast, how effectively a pre-existing DPPC monolayer prevents fibrinogen adsorption depends upon its surface pressure. 1,2-Dipalmitoylphosphatidylcholine 44-48 fibrinogen beta chain Homo sapiens 68-78 29618528-6 2018 At low DPPC surface pressures, fibrinogen penetrates DPPC monolayers, imparting a mixed viscoelastic shear response. 1,2-Dipalmitoylphosphatidylcholine 7-11 fibrinogen beta chain Homo sapiens 31-41 29618528-6 2018 At low DPPC surface pressures, fibrinogen penetrates DPPC monolayers, imparting a mixed viscoelastic shear response. 1,2-Dipalmitoylphosphatidylcholine 53-57 fibrinogen beta chain Homo sapiens 31-41 29618528-9 2018 Fibrinogen has a strong, albeit preparation-dependent, mechanical effect on phospholipid monolayers, which may contribute to LS inactivation and disorders such as ARDS. Phospholipids 76-88 fibrinogen beta chain Homo sapiens 0-10 29137999-4 2018 Lectin microarray analysis demonstrated increased glycosylation of fibrinogen due to aging, with predominant increase in high-mannose or hybrid type N-glycans, as well as tri-/tetraantennary complex N-glycans with greater content of galactose and N-acetylglucosamine residues. Mannose 126-133 fibrinogen beta chain Homo sapiens 67-77 29293453-7 2018 When the endothelial cells adhere to fibrinogen or fibronectin, PDI and alphaVbeta3 gain free thiol groups. Sulfhydryl Compounds 94-99 fibrinogen beta chain Homo sapiens 37-47 29137999-4 2018 Lectin microarray analysis demonstrated increased glycosylation of fibrinogen due to aging, with predominant increase in high-mannose or hybrid type N-glycans, as well as tri-/tetraantennary complex N-glycans with greater content of galactose and N-acetylglucosamine residues. Galactose 233-242 fibrinogen beta chain Homo sapiens 67-77 29137999-4 2018 Lectin microarray analysis demonstrated increased glycosylation of fibrinogen due to aging, with predominant increase in high-mannose or hybrid type N-glycans, as well as tri-/tetraantennary complex N-glycans with greater content of galactose and N-acetylglucosamine residues. Acetylglucosamine 247-266 fibrinogen beta chain Homo sapiens 67-77 29266558-3 2018 Here, cysteine cathepsins are investigated for their putative ability to hydrolyze fibrinogen, since they are potent proteases, first identified in lysosomal protein degradation and known to participate in extracellular proteolysis. Cysteine 6-14 fibrinogen beta chain Homo sapiens 83-93 29153710-0 2018 Silver nanoparticle/fibrinogen bilayers - Mechanism of formation and stability determined by in situ electrokinetic measurements. Silver 0-6 fibrinogen beta chain Homo sapiens 20-30 29973023-16 2018 Fibrinogen of patients in citrate group after CBP treatment was (3.5+-0.6) g/L, significantly higher than (3.0+-0.6) g/L in heparin group (t=-2.427, P<0.05). Citric Acid 26-33 fibrinogen beta chain Homo sapiens 0-10 29189631-11 2018 Lower pretransplant serum fibrinogen level (adjusted OR, 0.988; 95% CI, 0.979-0.998; P = 0.017) was associated with posttransplant EAH. eah 131-134 fibrinogen beta chain Homo sapiens 26-36 29031015-6 2018 The second derivative, fibrinogen and D-Dimer were significantly associated with a high PPS score (>=4): odds ratio (OR) = 1.53, 95% confidence interval (CI) = 1.03-2.28; OR = 1.91, 95% CI = 1.3-2.79; OR = 3.16, 95% CI = 2.29-4.36, respectively. pps 88-91 fibrinogen beta chain Homo sapiens 23-33 29449959-10 2018 Importantly, the hydrogel-coated PU substrates decrease 80% of surface-adsorbed fibrinogen and surface-attached hDFBs (compared with uncoated PU substrates), indicating the excellent anti-fouling activities of modified surfaces. Polyurethanes 33-35 fibrinogen beta chain Homo sapiens 80-90 29445102-7 2018 Analysis of high shear conditions indicated that platelets activated on fibrinogen, induced stress fibre formation, which was reversed by GSNO treatment. S-Nitrosoglutathione 138-142 fibrinogen beta chain Homo sapiens 72-82 29322134-2 2018 In this work, it was observed that Fib interacted with hemin to form a hemin-Fib composite. Hemin 55-60 fibrinogen beta chain Homo sapiens 35-38 29322134-2 2018 In this work, it was observed that Fib interacted with hemin to form a hemin-Fib composite. Hemin 55-60 fibrinogen beta chain Homo sapiens 77-80 29322134-3 2018 Because Fib prevented hemin from the formation of m-oxo-dimers, the hemin-Fib composite possesses excellent peroxidase-like activity. Hemin 22-27 fibrinogen beta chain Homo sapiens 8-11 29322134-3 2018 Because Fib prevented hemin from the formation of m-oxo-dimers, the hemin-Fib composite possesses excellent peroxidase-like activity. Hemin 22-27 fibrinogen beta chain Homo sapiens 74-77 29322134-5 2018 This allows us to utilize the H2O2-ABTS colorimetric system for the quantitative analysis of Fib. Hydrogen Peroxide 30-34 fibrinogen beta chain Homo sapiens 93-96 29322134-5 2018 This allows us to utilize the H2O2-ABTS colorimetric system for the quantitative analysis of Fib. 2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid 35-39 fibrinogen beta chain Homo sapiens 93-96 31149239-13 2018 Conclusions: Vitamin D status in conjunction with other parameters - such as T2DM - or serum biomarkers - namely fibrinogen level and PCR level - may point out the aggressive forms of NAFLD and the need for liver biopsy for appropriate management. Vitamin D 13-22 fibrinogen beta chain Homo sapiens 113-123 28972200-0 2018 Fibrinogen-modified sodium alginate as a scaffold material for skin tissue engineering. Alginates 20-35 fibrinogen beta chain Homo sapiens 0-10 28972200-1 2018 In search for a new pro-angiogenic scaffold material suitable for skin bioengineering and grafting therapy, we have fabricated a number of composite sodium alginate (AG)-fibrinogen (FG) sponge scaffolds using the freeze-drying approach. Alginates 149-164 fibrinogen beta chain Homo sapiens 170-180 29239953-12 2018 Production of fibrinogen fragments (represented by D-dimers) was significantly lower in the TXA group compared to group C. CONCLUSIONS: Early prehospital administration of TXA leads to clot stabilization and a reduction of fibrinolytic activity, causing a decrease in fibrin degradation products buildup (D-dimer). Tranexamic Acid 92-95 fibrinogen beta chain Homo sapiens 14-24 29239953-12 2018 Production of fibrinogen fragments (represented by D-dimers) was significantly lower in the TXA group compared to group C. CONCLUSIONS: Early prehospital administration of TXA leads to clot stabilization and a reduction of fibrinolytic activity, causing a decrease in fibrin degradation products buildup (D-dimer). Tranexamic Acid 172-175 fibrinogen beta chain Homo sapiens 14-24 29232592-4 2018 Since induction therapy with RIF and ATRA, the median levels of Fbg, PT and platelets were recovered to the normal range within 4days, 10days and 28days, respectively. Tretinoin 37-41 fibrinogen beta chain Homo sapiens 64-67 29194665-5 2018 RESULTS: Fibrinogen concentrate was used on-demand to treat 23 BEs in 11 patients, with 21 (91.3%) requiring a single infusion only. BES 63-66 fibrinogen beta chain Homo sapiens 9-19 29507706-5 2018 Also, plasma fibrinogen decreased (-12.1%, CI:-22.0,-0.92, p = 0.035) in the DAPS group. alpha,beta-diacryloxypropionic acid 77-81 fibrinogen beta chain Homo sapiens 13-23 30147809-0 2018 Do elevated blood levels of omega-3 fatty acids modify effects of particulate air pollutants on fibrinogen? Fatty Acids, Omega-3 28-47 fibrinogen beta chain Homo sapiens 96-106 30147809-2 2018 We now studied whether high blood levels of omega-3 (omega-3) fatty acids blunted this fibrinogen response to increased PM concentrations in these same patients. omega-3 (omega-3) fatty acids 44-73 fibrinogen beta chain Homo sapiens 87-97 30147809-5 2018 Each 5.6 mug/m3 increase in PM2.5 concentration in the previous hour was associated with a 3.1% increase in fibrinogen (95% CI = 1.5%, 4.7%) in those subjects with LOWMED total omega-3 fatty acid levels, but only a 0.9% increase (95% CI = - 1.5%, 3.2%) in patients with HIGH total omega-3 fatty acid levels. [4-(3-AMINOMETHYL-PHENYL)-PIPERIDIN-1-YL]-(5-PHENETHYL- PYRIDIN-3-YL)-METHANONE 28-31 fibrinogen beta chain Homo sapiens 108-118 30147809-5 2018 Each 5.6 mug/m3 increase in PM2.5 concentration in the previous hour was associated with a 3.1% increase in fibrinogen (95% CI = 1.5%, 4.7%) in those subjects with LOWMED total omega-3 fatty acid levels, but only a 0.9% increase (95% CI = - 1.5%, 3.2%) in patients with HIGH total omega-3 fatty acid levels. Fatty Acids, Omega-3 177-195 fibrinogen beta chain Homo sapiens 108-118 30147809-5 2018 Each 5.6 mug/m3 increase in PM2.5 concentration in the previous hour was associated with a 3.1% increase in fibrinogen (95% CI = 1.5%, 4.7%) in those subjects with LOWMED total omega-3 fatty acid levels, but only a 0.9% increase (95% CI = - 1.5%, 3.2%) in patients with HIGH total omega-3 fatty acid levels. Fatty Acids, Omega-3 281-299 fibrinogen beta chain Homo sapiens 108-118 30147809-8 2018 Thus, increased blood levels of fish-based omega-3 fatty acids attenuated increases in fibrinogen associated with short-term increases in ambient PM. Fatty Acids, Omega-3 43-62 fibrinogen beta chain Homo sapiens 87-97 31372222-7 2018 Changes in fibrinogen conformation as measured by intrinsic tryptophan fluorescence significantly decreased in the 300 muM SNAP (38057 + 1196 mean fluorescence intensity (MFI) and SNP (368617 + 541 MFI) groups versus the NAP control (47937 + 1196 MFI). Tryptophan 60-70 fibrinogen beta chain Homo sapiens 11-21 29085987-7 2018 Specifically, nonequilibrium capillary electrophoresis of equilibrium mixtures (NECEEM) was employed for the determination of equilibrium and rate constants for binding between citrate-stabilized AuNPs and two model proteins, lysozyme and fibrinogen. Citric Acid 177-184 fibrinogen beta chain Homo sapiens 239-249 28968301-10 2018 ETP was associated with thrombocytopenia (r = 0.472, P = 0.015) and weakly with fibrinogen level (r = 0.386, P = 0.047). etp 0-3 fibrinogen beta chain Homo sapiens 80-90 29110599-0 2018 Effect of Metformin on Plasma Fibrinogen Concentrations: A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Trials. Metformin 10-19 fibrinogen beta chain Homo sapiens 30-40 29110599-2 2018 Because metformin has shown a potential protective effect on different atherothrombotic risk factors, we assessed in this meta-analysis its effect on plasma fibrinogen concentrations. Metformin 8-17 fibrinogen beta chain Homo sapiens 157-167 29110599-3 2018 METHODS: A systematic review and meta-analysis was carried out to identify randomized placebo-controlled trials evaluating the effect of metformin administration on fibrinogen levels. Metformin 137-146 fibrinogen beta chain Homo sapiens 165-175 31372222-0 2018 Attenuation of Thrombin-Mediated Fibrin Formation via Changes in Fibrinogen Conformation Induced by Reaction with S-nitroso-N-acetylpenicillamine, but not S-nitrosoglutathione. S-Nitroso-N-Acetylpenicillamine 114-145 fibrinogen beta chain Homo sapiens 65-75 29578469-2 2018 In this study, a new solvent mixture of formic acid/acetic acid with low toxicity was investigated as an alternative solvent for fibrinogen electrospinning. formic acid 40-51 fibrinogen beta chain Homo sapiens 129-139 29578469-2 2018 In this study, a new solvent mixture of formic acid/acetic acid with low toxicity was investigated as an alternative solvent for fibrinogen electrospinning. Acetic Acid 52-63 fibrinogen beta chain Homo sapiens 129-139 29578469-6 2018 It is concluded that solvent mixture consisting of formic acid/acetic acid can be a great solvent for electrospinning of fibrinogen and is able to produce nanofiber structures. formic acid 51-62 fibrinogen beta chain Homo sapiens 121-131 29578469-6 2018 It is concluded that solvent mixture consisting of formic acid/acetic acid can be a great solvent for electrospinning of fibrinogen and is able to produce nanofiber structures. Acetic Acid 63-74 fibrinogen beta chain Homo sapiens 121-131 29972828-3 2018 However, DFPP removes some clotting factors (fibrinogen and factor XIII [FXIII]). dfpp 9-13 fibrinogen beta chain Homo sapiens 45-55 29972828-9 2018 CONCLUSION: We established a model in order to predict fibrinogen and FXIII depletion after DFPP sessions; it may help clinicians supplement fibrinogen and/or FXIII when appropriate. dfpp 92-96 fibrinogen beta chain Homo sapiens 55-65 31372222-8 2018 However, infused 1000 ppm NO gas had no direct effect on the ITF after 1 h incubation at 37 C. High performance liquid chromatography (HPLC) showed that fibrinogen degradation by 0.03 U/ml thrombin was concentration-dependently reduced after 1 h with SNAP but not with NAP or SNP. N-acetylpenicillamine 252-255 fibrinogen beta chain Homo sapiens 153-163 31372222-10 2018 These results suggest that NO donors such as SNAP and SNP induce fibrinogen conformational changes by potentially nitrosating fibrinogen tyrosine residues. Tyrosine 137-145 fibrinogen beta chain Homo sapiens 65-75 31372222-10 2018 These results suggest that NO donors such as SNAP and SNP induce fibrinogen conformational changes by potentially nitrosating fibrinogen tyrosine residues. Tyrosine 137-145 fibrinogen beta chain Homo sapiens 126-136 29317059-4 2018 This phenomenon can now be explained in terms of the modification of fibrinogen structure induced by hydroxyl radicals generated during the period of ischemia caused, in turn, by the blocking of the blood flow within the obstructed vessels. Hydroxyl Radical 101-118 fibrinogen beta chain Homo sapiens 69-79 29075923-4 2018 Fibrinogen was incubated with HTL at different molar ratios and structural changes of the protein were assessed by polyacrylamide gel electrophoresis (PAGE), capillary zone electrophoresis (CZE) and capillary isoelectric focusing (CIEF). polyacrylamide 115-129 fibrinogen beta chain Homo sapiens 0-10 29075923-8 2018 The results show a reducing action of HTL on the fibrinogen molecule, probably attributed to the sulfhydryl groups generated by N-homocysteinylation and/or by the ones present in the homocysteine molecule yielded by HTL hydrolysis. Homocysteine 183-195 fibrinogen beta chain Homo sapiens 49-59 29317059-5 2018 Fibrinogen modification involves intra-to intermolecular disulfide rearrangement induced by the reductive power of hydroxyl radicals that result in the exposition of buried hydrophobic epitopes. Disulfides 57-66 fibrinogen beta chain Homo sapiens 0-10 29317059-5 2018 Fibrinogen modification involves intra-to intermolecular disulfide rearrangement induced by the reductive power of hydroxyl radicals that result in the exposition of buried hydrophobic epitopes. Hydroxyl Radical 115-132 fibrinogen beta chain Homo sapiens 0-10 29317059-7 2018 Also, limited reduction of human serum albumin (HSA) generates hydrophobic polymers that form huge insoluble complexes with fibrinogen. Polymers 75-83 fibrinogen beta chain Homo sapiens 124-134 29304525-7 2018 SRH was inversely associated with fibrinogen (r = - 0.25, p = 0.001) and D-dimer (r = - 0.17, p = 0.021) levels in the bivariate analysis. 4-(Indolin-1-yl)-4-oxobutanoic acid 0-3 fibrinogen beta chain Homo sapiens 34-44 29310141-0 2018 Mutation of the -RPVR- Propeptide Motif at C-Terminal of the Aalpha Chain Is Associated with Decreased Fibrinogen Expression. propeptide 23-33 fibrinogen beta chain Homo sapiens 103-113 29299315-0 2017 A novel fibrinogen mutation: FGA g. 3057 C > T (p. Arg104 > Cys) impairs fibrinogen secretion. Cysteine 66-69 fibrinogen beta chain Homo sapiens 8-18 29284430-10 2017 However, asymptomatic DIC developed after 47 days, and her serum fibrinogen level declined to 42 mg/dL, which was successfully treated with anticoagulant therapy by a therapeutic dose of intravenous heparin for 22 days (postoperative days 48-69). Heparin 199-206 fibrinogen beta chain Homo sapiens 65-75 29390596-6 2017 Results: CKDu patients had significantly elevated urinarylevels of fibrinogen (198.2 ng/mg creatinine p<0.001),clusterin (3479 ng/mg creatinine p<0.001), cystatin-C(5124.8 ng/mg creatinine p<0.001) and beta2-microglobulin(9913.4 ng/mg creatinine p<0.001) compared to the controlgroups. Creatinine 91-101 fibrinogen beta chain Homo sapiens 67-77 29390596-8 2017 Urinary fibrinogen and KIM-1 levelscorrelated positively with urinary arsenic levels. Arsenic 70-77 fibrinogen beta chain Homo sapiens 8-18 29299315-0 2017 A novel fibrinogen mutation: FGA g. 3057 C > T (p. Arg104 > Cys) impairs fibrinogen secretion. Cysteine 66-69 fibrinogen beta chain Homo sapiens 79-89 29299315-5 2017 Purified fibrinogen was incubated with plasmin, and the degradation products analyzed by SDS/PAGE. Sodium Dodecyl Sulfate 89-92 fibrinogen beta chain Homo sapiens 9-19 28903970-5 2017 RESULTS: Median (interquartile range) urinary fibrinogen-to-creatinine ratio was 536 (191-1461) ng/mg for patients with CKD, significantly higher than 2 (2-3) ng/mg for healthy controls (P<0.001). Creatinine 60-70 fibrinogen beta chain Homo sapiens 46-56 28903970-8 2017 Higher urinary fibrinogen level was associated with increased risk of ESRD (hazard ratio, 2.12; 95% confidence interval, 1.31 to 3.26) per log10 higher urinary fibrinogen-to-creatinine ratio (P=0.003) adjusting for age, sex, BP, urine protein, disease type, eGFR, and interstitial fibrosis and tubular atrophy. Creatinine 174-184 fibrinogen beta chain Homo sapiens 15-25 28903970-8 2017 Higher urinary fibrinogen level was associated with increased risk of ESRD (hazard ratio, 2.12; 95% confidence interval, 1.31 to 3.26) per log10 higher urinary fibrinogen-to-creatinine ratio (P=0.003) adjusting for age, sex, BP, urine protein, disease type, eGFR, and interstitial fibrosis and tubular atrophy. Creatinine 174-184 fibrinogen beta chain Homo sapiens 160-170 28958718-0 2017 Galloyl groups-regulated fibrinogen conformation: Understanding antiplatelet adhesion on tannic acid coating. Tannins 89-100 fibrinogen beta chain Homo sapiens 25-35 28958718-10 2017 In this study, we demonstrated for the first time that tannic acid surface with abundant galloyl groups could induce minimal conformational changes of fibrinogen, eventually leading to an outstanding antiplatelet adhesion effect. Tannins 55-66 fibrinogen beta chain Homo sapiens 151-161 28958718-10 2017 In this study, we demonstrated for the first time that tannic acid surface with abundant galloyl groups could induce minimal conformational changes of fibrinogen, eventually leading to an outstanding antiplatelet adhesion effect. galloyl 89-96 fibrinogen beta chain Homo sapiens 151-161 29766007-4 2017 Fibrinogen may undergo non-enzymatic nitration, which may result from exposure to nitric oxide in cigarette smoke. Nitric Oxide 82-94 fibrinogen beta chain Homo sapiens 0-10 27301773-8 2017 However, OS was significantly better in the low fibrinogen group (27.3 vs 13.5 months; p = 0.0009) as well as progression-free survival (12.3 vs 7.8 months; p = 0.0076). Osmium 9-11 fibrinogen beta chain Homo sapiens 48-58 29111093-6 2017 Current research indicates that the following are independent markers for positive MES: high level of serum soluble P-selectin, chemokine (C-X-C motif) ligand 16 (CXCL16) and fibrinogen, high neutrophil count, reduced ratio of CD4+CD25high regulatory T cells (Tregs) and the C allele of tumor necrosis factor receptor superfamily member 11B (TNFRSF11B) rs3102735. 2-(N-morpholino)ethanesulfonic acid 83-86 fibrinogen beta chain Homo sapiens 175-185 28985605-9 2017 However, they also contain a small amount of polyglycidol chains, making the adsorption of fibrinogen weaker than the adsorption onto the pure polystyrene. polyglycidol 45-57 fibrinogen beta chain Homo sapiens 91-101 28985605-10 2017 Studies of covalent immobilization of fibrinogen on the microspheres via 1,3,5-trichlorotriazine confirmed these findings. cyanuric chloride 73-96 fibrinogen beta chain Homo sapiens 38-48 28766854-4 2017 METHODS: Samples from donors with dysfibrinogenaemia (sample 1: gamma p.Arg301Cys, sample 2: Bbeta166Arg3Cys-Fgn Longmont, sample 3: Aalpha p.Arg35His) and a normal donor were sent to laboratories for investigation for possible dysfibrinogenaemia. bbeta166arg3cys 93-108 fibrinogen beta chain Homo sapiens 109-112 28766891-0 2017 Influences of argatroban on five fibrinogen assays. argatroban 14-24 fibrinogen beta chain Homo sapiens 33-43 28766891-7 2017 Compared with the NAHF, significant reduction was observed on Fibrinogen-C XL (P<.01), while no influences were shown on the others (STA-Fibrinogen: P=.41, Siemens Thrombin: P=.20, RecombiPlasTin 2G: P=.21) when activated partial thromboplastin time (APTT) ratio was no more than 3.0. nahf 18-22 fibrinogen beta chain Homo sapiens 62-72 28766891-9 2017 CONCLUSION: The influences of argatroban on fibrinogen assays differ greatly, clinicians should be aware of the influences of argatroban on the fibrinogen assays used on site to avoid misdiagnoses. argatroban 126-136 fibrinogen beta chain Homo sapiens 144-154 27709645-4 2017 His skin lesions improved along with decreased IgG BP180 antibodies, but factor XIII (FXIII) and fibrinogen were also reduced by DFPP repetition. dfpp 129-133 fibrinogen beta chain Homo sapiens 97-107 27709645-9 2017 For this case, we measured the mean of reduction ratios in serum IgG and FXIII both before and after plasmapheresis sessions and detected the decreased levels of FXIII and fibrinogen during DFPP. dfpp 190-194 fibrinogen beta chain Homo sapiens 172-182 28728032-2 2017 Using the model system of fluorescein-tagged fibrinogen we demonstrated that, for fluorescein tags on adsorbed fibrinogen, emission intensity was very sensitive to the salt concentration. Fluorescein 26-37 fibrinogen beta chain Homo sapiens 45-55 28602126-7 2017 Normalized LAC ratio was positively correlated with D-dimer, fibrinogen, and procoagulant activity of coagulating factor VIII, and negatively correlated with antithrombin activity, respectively ( P < .01). Lactose 11-14 fibrinogen beta chain Homo sapiens 61-71 29096248-3 2017 We detected a novel RGD (Arg-Gly-Asp)-containing peptide derived from the C-terminal portion of fibrinogen in the sera of metastatic patients that appeared to control the EMT (epithelial-mesenchymal transition) of cancer cells, in a process associated with miR-199a-3p. Arginine 25-28 fibrinogen beta chain Homo sapiens 96-106 29096248-3 2017 We detected a novel RGD (Arg-Gly-Asp)-containing peptide derived from the C-terminal portion of fibrinogen in the sera of metastatic patients that appeared to control the EMT (epithelial-mesenchymal transition) of cancer cells, in a process associated with miR-199a-3p. Glycine 29-32 fibrinogen beta chain Homo sapiens 96-106 29096248-3 2017 We detected a novel RGD (Arg-Gly-Asp)-containing peptide derived from the C-terminal portion of fibrinogen in the sera of metastatic patients that appeared to control the EMT (epithelial-mesenchymal transition) of cancer cells, in a process associated with miR-199a-3p. Aspartic Acid 33-36 fibrinogen beta chain Homo sapiens 96-106 29134801-4 2017 The most protein-resistant copolymer layers, eliminating fibrinogen and lysozyme adsorption within detectible limits of 0.01 mg/m2, had metrics (the amount of pMPC at the surface and the reduced tether footprint) consistent with the formation of an interfacial polymer brush. copolymer 27-36 fibrinogen beta chain Homo sapiens 57-67 29134801-4 2017 The most protein-resistant copolymer layers, eliminating fibrinogen and lysozyme adsorption within detectible limits of 0.01 mg/m2, had metrics (the amount of pMPC at the surface and the reduced tether footprint) consistent with the formation of an interfacial polymer brush. Polymers 29-36 fibrinogen beta chain Homo sapiens 57-67 29134801-7 2017 Although the optimized p(TMAEMA-b-MPC) and PLL-PEG copolymers were similarly fibrinogen-resistant, the cationic protein lysozyme was repelled by pMPC but adhered to the PEG brush via PEG-lysozyme attractions. Polyethylene Glycols 47-50 fibrinogen beta chain Homo sapiens 77-87 28786129-8 2017 We estimate the controlled direct effect of air pollution on the qth percentile of fibrinogen and its indirect effect through a change in the pth percentile of IFN-gamma methylation. pth 142-145 fibrinogen beta chain Homo sapiens 83-93 28728032-2 2017 Using the model system of fluorescein-tagged fibrinogen we demonstrated that, for fluorescein tags on adsorbed fibrinogen, emission intensity was very sensitive to the salt concentration. Fluorescein 26-37 fibrinogen beta chain Homo sapiens 111-121 28728032-2 2017 Using the model system of fluorescein-tagged fibrinogen we demonstrated that, for fluorescein tags on adsorbed fibrinogen, emission intensity was very sensitive to the salt concentration. Fluorescein 82-93 fibrinogen beta chain Homo sapiens 45-55 28728032-2 2017 Using the model system of fluorescein-tagged fibrinogen we demonstrated that, for fluorescein tags on adsorbed fibrinogen, emission intensity was very sensitive to the salt concentration. Fluorescein 82-93 fibrinogen beta chain Homo sapiens 111-121 28728032-2 2017 Using the model system of fluorescein-tagged fibrinogen we demonstrated that, for fluorescein tags on adsorbed fibrinogen, emission intensity was very sensitive to the salt concentration. Salts 168-172 fibrinogen beta chain Homo sapiens 45-55 28728032-2 2017 Using the model system of fluorescein-tagged fibrinogen we demonstrated that, for fluorescein tags on adsorbed fibrinogen, emission intensity was very sensitive to the salt concentration. Salts 168-172 fibrinogen beta chain Homo sapiens 111-121 28556996-0 2017 Semi-high-throughput isolation and N-glycan analysis of human fibrinogen using monolithic supports bearing monoclonal anti-human fibrinogen antibodies. n-glycan 35-43 fibrinogen beta chain Homo sapiens 62-72 28778061-0 2017 Studies on the interaction of polylactid-based planar and nanoparticular biomaterials with serum albumin and fibrinogen. polylactid 30-40 fibrinogen beta chain Homo sapiens 109-119 28150441-3 2017 ITC analysis indicated that the binding of EuP-82 to fibrinogen in the conditions with or without the activator (Ca2+ ) was an exothermic reaction (dominant negative enthalpy), which tended to be driven by hydrogen bonding and van der Waals interactions. Hydrogen 206-214 fibrinogen beta chain Homo sapiens 53-63 28150441-4 2017 In contrast, the binding of fibrinogen-EuP-82 in the condition with the inhibitor (Zn2+ ) was an unfavorable endothermic reaction. Zinc 83-87 fibrinogen beta chain Homo sapiens 28-38 28432753-5 2017 Specifically, indothiazinone treatment significantly inhibited the binding of fibrinogen to Chinese hamster ovary cells expressing integrin alphaIIbbeta3. indothiazinone 14-28 fibrinogen beta chain Homo sapiens 78-88 28432753-6 2017 It also restricted thrombin- and adenosine diphosphate-dependent spreading of human platelets on a fibrinogen matrix. Adenosine Diphosphate 33-54 fibrinogen beta chain Homo sapiens 99-109 29096750-10 2017 In the peripheral blood from patients received LPE treatment, the levels of immunoglobulin, complement, monocytes and fibrinogen were significantly reduced. LPC-ETHER 47-50 fibrinogen beta chain Homo sapiens 118-128 29050713-12 2017 There was a negative correlation between PRBC and preoperative fibrinogen (r = -0.46). prbc 41-45 fibrinogen beta chain Homo sapiens 63-73 28816342-0 2017 Hypofibrinogenaemia associated with novel Aalpha126Val Asp mutation in the fibrinogen coiled coil. Aspartic Acid 55-58 fibrinogen beta chain Homo sapiens 4-14 29022982-2 2017 We report here the influence of the poly(ethylene glycol) (PEG) grafting density in model phospholipid monolayers on the adsorption behavior of bovine serum albumin and human fibrinogen, not only with respect to the amount of adsorbed protein, but also its orientational ordering on the surface. Polyethylene Glycols 36-57 fibrinogen beta chain Homo sapiens 175-185 29022982-2 2017 We report here the influence of the poly(ethylene glycol) (PEG) grafting density in model phospholipid monolayers on the adsorption behavior of bovine serum albumin and human fibrinogen, not only with respect to the amount of adsorbed protein, but also its orientational ordering on the surface. Polyethylene Glycols 59-62 fibrinogen beta chain Homo sapiens 175-185 29022982-2 2017 We report here the influence of the poly(ethylene glycol) (PEG) grafting density in model phospholipid monolayers on the adsorption behavior of bovine serum albumin and human fibrinogen, not only with respect to the amount of adsorbed protein, but also its orientational ordering on the surface. Phospholipids 90-102 fibrinogen beta chain Homo sapiens 175-185 29228758-7 2017 Patients with higher serum fibrinogen levels had elevated serum creatinine levels, 24-hour urinary protein, and blood pressure compared with patients with the lowest levels of serum fibrinogen as well as severe renal damage at the time of renal biopsy. Creatinine 64-74 fibrinogen beta chain Homo sapiens 27-37 28548908-9 2017 We also investigated protein adsorption behavior in terms of the amount and deformation of fibrinogen adsorbed on the polymer surface. Polymers 118-125 fibrinogen beta chain Homo sapiens 91-101 28885030-6 2017 The d-lysine grafted surface had a greater ability to inhibit both bovine serum albumin and fibrinogen adsorption, along with less degeneration of fibrinogen compared to the l-lysine anchored surface. D-Lysine 4-12 fibrinogen beta chain Homo sapiens 92-102 28885030-6 2017 The d-lysine grafted surface had a greater ability to inhibit both bovine serum albumin and fibrinogen adsorption, along with less degeneration of fibrinogen compared to the l-lysine anchored surface. D-Lysine 4-12 fibrinogen beta chain Homo sapiens 147-157 28885030-7 2017 However, the d-tartaric acid grafted surface adsorbed more protein but with less denatured fibrinogen compared to the l-tartaric acid grafted one. tartaric acid 13-28 fibrinogen beta chain Homo sapiens 91-101 28726133-1 2017 While the administration of antivenom to treat hemotoxic snake bite injury remains the gold standard of therapy, we have demonstrated that modifying human fibrinogen with iron and carbon monoxide renders it resistant to fibrinogenolytic snake venom enzymes. Iron 171-175 fibrinogen beta chain Homo sapiens 155-165 28726133-1 2017 While the administration of antivenom to treat hemotoxic snake bite injury remains the gold standard of therapy, we have demonstrated that modifying human fibrinogen with iron and carbon monoxide renders it resistant to fibrinogenolytic snake venom enzymes. Carbon Monoxide 180-195 fibrinogen beta chain Homo sapiens 155-165 28760491-0 2017 Effects of tibolone on fibrinogen and antithrombin III: A systematic review and meta-analysis of controlled trials. tibolone 11-19 fibrinogen beta chain Homo sapiens 23-33 28509812-7 2017 Ospemifene significantly improved fibrinogen and protein C antigen levels relative to placebo at months 3 (-8.7% vs -0.8% and -2.7% vs 0.5%, respectively), 6 (-6.0% vs 6.7% and -3.6 vs 8.0%), and 12 (-8.7% vs 7.3% and -4.5% vs 6.6%; P < 0.01, for all). Ospemifene 0-10 fibrinogen beta chain Homo sapiens 34-44 28760491-1 2017 Tibolone is a synthetic steroid with estrogenic, androgenic and progestogenic activity, but the evidence regarding its effects on fibrinogen and antithrombin III (ATIII) has not been conclusive. tibolone 0-8 fibrinogen beta chain Homo sapiens 130-140 28760491-2 2017 We assessed the impact of tibolone on fibrinogen and ATIII through a systematic review and meta-analysis of available randomized controlled trials (RCTs). tibolone 26-34 fibrinogen beta chain Homo sapiens 38-48 28760491-3 2017 The search included PUBMED, Web of Science, Scopus, and Google Scholar (up to January 31st, 2016) to identify controlled clinical studies investigating the effects of oral tibolone treatment on fibrinogen and ATIII. tibolone 172-180 fibrinogen beta chain Homo sapiens 194-204 28760491-4 2017 Overall, the impact of tibolone on plasma fibrinogen concentrations was reported in 10 trials comprising 11 treatment arms. tibolone 23-31 fibrinogen beta chain Homo sapiens 42-52 28771557-8 2017 Low-moderate arsenic exposure was positively associated with baseline fibrinogen in participants with diabetes and unexpectedly inversely associated with PAI-1. Arsenic 13-20 fibrinogen beta chain Homo sapiens 70-80 29744434-9 2017 Finally, the cytocompatibility of fibrinogen/knob-g-HA hydrogels was proved by live/dead stainings and MTT assays in the 293T cells encapsulation test. monooxyethylene trimethylolpropane tristearate 103-106 fibrinogen beta chain Homo sapiens 34-44 28874469-5 2017 We show that while FnBPs bind to Plg through weak (~200-pN) molecular bonds, direct interaction of the adhesins with Fg through the high-affinity dock, lock, and latch mechanism dramatically increases the strength of the FnBP-Plg bond (up to ~2,000 pN). fnbp 19-23 fibrinogen beta chain Homo sapiens 117-119 28830477-15 2017 Although the increase in lactate level was correlated with the deterioration of coagulofibrinolytic variables (prolonged prothrombin time and activated partial thromboplastin time, decreased fibrinogen levels, and increased D-dimer levels) in the non-TBI group, no such correlation was observed in the TBI group. Lactic Acid 25-32 fibrinogen beta chain Homo sapiens 191-201 28751572-8 2017 However, black carbon, sulfate, and nitrogen oxides were negatively associated with fibrinogen, and sulfate was negatively associated with tumor necrosis factor alpha. Carbon 15-21 fibrinogen beta chain Homo sapiens 84-94 28751572-8 2017 However, black carbon, sulfate, and nitrogen oxides were negatively associated with fibrinogen, and sulfate was negatively associated with tumor necrosis factor alpha. Nitrogen 36-44 fibrinogen beta chain Homo sapiens 84-94 27771416-10 2017 SNPs significantly associated with the fibrinogen phenotypes, resulted in a total of 75 TFBS changes, of which 35 resulted in a loss and 40 in a gain of TFBS. tfbs 88-92 fibrinogen beta chain Homo sapiens 39-49 28291703-6 2017 On multivariable analysis, positive FAST finding, GCS, Fib, and FDP influenced the requirement of pRBC transfusion. prbc 98-102 fibrinogen beta chain Homo sapiens 55-58 28291703-7 2017 In the area under the receiver operating characteristic curve analysis, Fib and FDP were markers that predicted the requirement of pRBC transfusion. prbc 131-135 fibrinogen beta chain Homo sapiens 72-75 28291703-8 2017 The FDP/Fib ratio had a better correlation with the requirement of pRBC transfusion than FDP or Fib. prbc 67-71 fibrinogen beta chain Homo sapiens 8-11 28291703-9 2017 CONCLUSIONS: The FDP/Fib ratio can be easily measured and may be a predictor of the need for pRBC transfusion. prbc 93-97 fibrinogen beta chain Homo sapiens 21-24 28064371-6 2017 Total cholesterol and fibrinogen levels were found to be independent risk factors for patients in the 4th quartile distribution of the ETP distribution (OR (95% CI)) 2.6 (1.2 to 5.4) (P = 0.01) and 2.2 (1.1 to 4.5 (P = 0.03). etp 135-138 fibrinogen beta chain Homo sapiens 22-32 28750085-5 2017 Cannabinoid receptor types 1(CB1R) agonist arachidonyl-2"-chloroethylamide (ACEA) up-regulated transcription of fibrinogen via induction of ERRgamma, whereas knockdown of ERRgamma attenuated fibrinogen expression. arachidonyl-2-chloroethylamide 76-80 fibrinogen beta chain Homo sapiens 191-201 28598173-0 2017 Nanocrystal Width Controls Fibrinogen Orientation and Assembly Kinetics on Poly(butene-1) Surfaces. poly(butene-1) 75-89 fibrinogen beta chain Homo sapiens 27-37 28296337-5 2017 Liquid chromatography mass spectrometry (LC-MS) identified sites of homocitrullines (carbamylated lysines) present in the human fibrinogen beta-chain. homocitrulline 68-83 fibrinogen beta chain Homo sapiens 128-149 28296337-5 2017 Liquid chromatography mass spectrometry (LC-MS) identified sites of homocitrullines (carbamylated lysines) present in the human fibrinogen beta-chain. carbamylated lysines 85-105 fibrinogen beta chain Homo sapiens 128-149 28296337-8 2017 LC-MS identified carbamylation of 9 of 34 lysines in the human fibrinogen beta-chain. Lysine 42-49 fibrinogen beta chain Homo sapiens 63-84 28296337-11 2017 CONCLUSION: Anti-CarP antibodies appear to preferentially target specific regions of the human fibrinogen beta-chain that contain homocitrullines. homocitrulline 130-145 fibrinogen beta chain Homo sapiens 95-116 28745782-6 2017 At the end of follow-up, the high concentration heparin group had reduced fibrinogen (FIB) and increased D-D compared with the other groups, and the differences were statistically significant (p<0.05). Heparin 48-55 fibrinogen beta chain Homo sapiens 74-84 28745782-6 2017 At the end of follow-up, the high concentration heparin group had reduced fibrinogen (FIB) and increased D-D compared with the other groups, and the differences were statistically significant (p<0.05). Heparin 48-55 fibrinogen beta chain Homo sapiens 86-89 28750085-5 2017 Cannabinoid receptor types 1(CB1R) agonist arachidonyl-2"-chloroethylamide (ACEA) up-regulated transcription of fibrinogen via induction of ERRgamma, whereas knockdown of ERRgamma attenuated fibrinogen expression. arachidonyl-2-chloroethylamide 43-74 fibrinogen beta chain Homo sapiens 112-122 28750085-5 2017 Cannabinoid receptor types 1(CB1R) agonist arachidonyl-2"-chloroethylamide (ACEA) up-regulated transcription of fibrinogen via induction of ERRgamma, whereas knockdown of ERRgamma attenuated fibrinogen expression. arachidonyl-2-chloroethylamide 76-80 fibrinogen beta chain Homo sapiens 112-122 28804682-9 2017 For the inflammatory biomarkers at 24 hours after PCI, the fibrinogen level was significantly increased in the atorvastatin group; the hs-CRP levels were significantly increased in both groups, however, the hs-CRP level in the pitavastatin group was lower than that in the atorvastatin group. Atorvastatin 111-123 fibrinogen beta chain Homo sapiens 59-69 27755019-0 2017 Exposure of fibrinogen and thrombin to nitric oxide donor ProliNONOate affects fibrin clot properties. Nitric Oxide 39-51 fibrinogen beta chain Homo sapiens 12-22 27755019-0 2017 Exposure of fibrinogen and thrombin to nitric oxide donor ProliNONOate affects fibrin clot properties. prolinonoate 58-70 fibrinogen beta chain Homo sapiens 12-22 27755019-4 2017 The objective of our study was to determine the effect of thrombin and fibrinogen exposed to nitric oxide on fibrin clot properties. Nitric Oxide 93-105 fibrinogen beta chain Homo sapiens 71-81 27755019-5 2017 ProliNONOate (5 mumol/l) was added to fibrinogen and thrombin before clot initiation and immediately following the addition of thrombin to the fibrinogen solution. prolinonoate 0-12 fibrinogen beta chain Homo sapiens 38-48 27755019-5 2017 ProliNONOate (5 mumol/l) was added to fibrinogen and thrombin before clot initiation and immediately following the addition of thrombin to the fibrinogen solution. prolinonoate 0-12 fibrinogen beta chain Homo sapiens 143-153 27755019-9 2017 The addition of ProliNONOate to fibrinogen or thrombin resulted in a change in clot structure. prolinonoate 16-28 fibrinogen beta chain Homo sapiens 32-42 27771416-10 2017 SNPs significantly associated with the fibrinogen phenotypes, resulted in a total of 75 TFBS changes, of which 35 resulted in a loss and 40 in a gain of TFBS. tfbs 153-157 fibrinogen beta chain Homo sapiens 39-49 28466898-8 2017 Therefore, CarboSil 2080A incorporated with SNAP and top-coated with SP60D60 was tested for antibacterial efficacy after exposure to fibrinogen, an abundantly found protein in blood. carbosil 11-19 fibrinogen beta chain Homo sapiens 133-143 28168836-9 2017 Binding of Efb to human fibrinogen was blocked in human, monkey, gerbil and pig plasma, while human, monkey, gerbil, rabbit, cat and guinea pig plasma inhibited the binding of Efb to human C3. Oligomycin B 11-14 fibrinogen beta chain Homo sapiens 24-34 28555432-10 2017 CPro degrades the subunits of human fibrinogen in the order Aalpha > Bbeta > gamma. cpro 0-4 fibrinogen beta chain Homo sapiens 36-46 28408375-4 2017 APPROACH AND RESULTS: Herein, we report a positive relationship between serum UA and acute-phase reactants, such as high-sensitivity C-reactive protein, fibrinogen, ferritin, complement C3, and erythrocyte sedimentation rate, in a cohort of 2731 nondiabetic adults. Uric Acid 78-80 fibrinogen beta chain Homo sapiens 153-163 28408375-7 2017 We show that UA stimulates the expression of C-reactive protein, fibrinogen, ferritin, and complement C3 in a dose-dependent fashion. Uric Acid 13-15 fibrinogen beta chain Homo sapiens 65-75 28661087-1 2017 Immunoadsorption with a tryptophan-conjugated column has a limited capacity and reduces fibrinogen. Tryptophan 24-34 fibrinogen beta chain Homo sapiens 88-98 28772927-6 2017 Fibrinogen"s binding sites however, also contain the same carboxylate groups as collagen. carboxylate 58-69 fibrinogen beta chain Homo sapiens 0-10 28057772-6 2017 We also purified fibrinogen from healthy controls and patients on hemodialysis using the calcium-dependent IF-1 mAb against fibrinogen for additional investigation using mass spectrometric analysis and electron microscopy. Calcium 89-96 fibrinogen beta chain Homo sapiens 124-134 28365482-0 2017 Distributed vasculogenesis from modular agarose-hydroxyapatite-fibrinogen microbeads. Sepharose 40-47 fibrinogen beta chain Homo sapiens 63-73 28365482-16 2017 In this study, we developed small, non-aggregating agarose-hydroxyapatite-fibrinogen microbeads that contained endothelial cells and fibroblasts. Sepharose 51-58 fibrinogen beta chain Homo sapiens 74-84 28161763-6 2017 Six CHO and HuH-7 cell lines that transiently produced FSD-inducible variant fibrinogen presented the fibrous (3.2-22.7 and 2.1-24.5%, respectively) and large granular (5.4-25.5 and 7.7-23.9%) forms of intracellular inclusion bodies. cho 4-7 fibrinogen beta chain Homo sapiens 77-87 28161763-6 2017 Six CHO and HuH-7 cell lines that transiently produced FSD-inducible variant fibrinogen presented the fibrous (3.2-22.7 and 2.1-24.5%, respectively) and large granular (5.4-25.5 and 7.7-23.9%) forms of intracellular inclusion bodies. FSD 55-58 fibrinogen beta chain Homo sapiens 77-87 28366713-0 2017 Influence of Heparin on the Fibrinogen Level Measured by the Prothrombin Time-Derived Method During Cardiac Surgery With Cardiopulmonary Bypass. Heparin 13-20 fibrinogen beta chain Homo sapiens 28-38 28171788-8 2017 Excellent specific character of the homemade hemin-based monolith was that it could simultaneously remove high-abundance proteins (including human serum albumin, immunoglobulin G, and human fibrinogen) from human plasma and separate other proteins to different fractions. Hemin 45-50 fibrinogen beta chain Homo sapiens 190-200 28382370-4 2017 As aggregation and cross-linking of fibrin monomers rely on lysine residues, it is likely that carbamylation impacts fibrinogen processing. Lysine 60-66 fibrinogen beta chain Homo sapiens 117-127 28382370-7 2017 LC-MS/MS analyses revealed significantly higher homocitrulline levels in patient fibrinogen than in fibrinogen isolated from control plasma. homocitrulline 48-62 fibrinogen beta chain Homo sapiens 81-91 28263863-3 2017 We exposed polymers with different surface chemistries to protease-free human fibrinogen. Polymers 11-19 fibrinogen beta chain Homo sapiens 78-88 28567087-8 2017 Irrespective of regimen, the changes in fibrinogen and vWF:Ag levels were mainly associated with the change in ADP-mediated PR (r=0.339, p=0.008 and r=0.322, p=0.012, respectively). Adenosine Diphosphate 111-114 fibrinogen beta chain Homo sapiens 40-50 28567087-9 2017 CONCLUSION: In patients with NVAF, combination antiplatelet therapy showed reductions for vWF:Ag and fibrinogen levels, which may be associated with the inhibitory levels of ADP-mediated PR. nvaf 29-33 fibrinogen beta chain Homo sapiens 101-111 28567087-9 2017 CONCLUSION: In patients with NVAF, combination antiplatelet therapy showed reductions for vWF:Ag and fibrinogen levels, which may be associated with the inhibitory levels of ADP-mediated PR. Adenosine Diphosphate 174-177 fibrinogen beta chain Homo sapiens 101-111 29296957-0 2017 alphaIIbbeta3 binding to a fibrinogen fragment lacking the gamma-chain dodecapeptide is activation dependent and EDTA inducible. Edetic Acid 113-117 fibrinogen beta chain Homo sapiens 27-37 27797973-5 2017 Patients with low glycerophospholipids presented with more systemic inflammation (C-reactive protein and fibrinogen negatively and albumin positively correlated) but less adaptive immune cell tumor infiltration (lower tumor and immune cell PD-L1 expression), less oxygenic respiration and increased triglyceride biosynthesis in tumor cells, and lower histone expressions, correlating with higher numbers of expressed genes and more transcriptional noise, a putative neo-pluripotent tumor cell phenotype.Conclusions: Low serum phospholipids and essential amino acids are correlated with worse outcome in ovarian cancer, accompanied by a specific tumor cell phenotype. Glycerophospholipids 18-38 fibrinogen beta chain Homo sapiens 105-115 27797973-5 2017 Patients with low glycerophospholipids presented with more systemic inflammation (C-reactive protein and fibrinogen negatively and albumin positively correlated) but less adaptive immune cell tumor infiltration (lower tumor and immune cell PD-L1 expression), less oxygenic respiration and increased triglyceride biosynthesis in tumor cells, and lower histone expressions, correlating with higher numbers of expressed genes and more transcriptional noise, a putative neo-pluripotent tumor cell phenotype.Conclusions: Low serum phospholipids and essential amino acids are correlated with worse outcome in ovarian cancer, accompanied by a specific tumor cell phenotype. Phospholipids 25-38 fibrinogen beta chain Homo sapiens 105-115 28276243-8 2017 For larger proteins like fibrinogen, adsorption is expected to occur mainly "on top" of the polymer brush, and brush thickness determines whether protein is located in the "detectable zone". Polymers 92-99 fibrinogen beta chain Homo sapiens 25-35 28400980-8 2017 The presence of CMBs in ischemic stroke patients with atrial fibrillation and/or rheumatic heart disease is associated with elevated levels of fibrinogen. cmbs 16-20 fibrinogen beta chain Homo sapiens 143-153 28095333-0 2017 Effect of resveratrol on platelet aggregation by fibrinogen protection. Resveratrol 10-21 fibrinogen beta chain Homo sapiens 49-59 27557548-11 2017 In contrast, MCV associated inversely with platelet reactivity as judged from surface-attached fibrinogen after ADP (1.7 mumol/L) (p < 0.05) and TRAP-6 provocation (57 mumol/L (p = 0.01) and 74 mumol/L (p < 0.05)). Adenosine Diphosphate 112-115 fibrinogen beta chain Homo sapiens 95-105 27921196-7 2017 Additionally, DS could also further reduce the content of fibrinogen, adjust blood lipid level, correct T wave inversion, and so on. Deuterium 14-16 fibrinogen beta chain Homo sapiens 58-68 28167447-7 2017 RESULTS: Each 0.13microg/m3 increase in Delta-C concentration in the prior 12h was associated with a 0.91% increase in fibrinogen levels (95% CI=0.23%, 1.59%), but unexpectedly in the prior 48h, each 0.17microg/m3 increase in Delta-C concentration was associated with a 2.75% decrease in MPO levels (95% CI=-5.13%,-0.37%). delta-c 40-47 fibrinogen beta chain Homo sapiens 119-129 28167447-9 2017 Interquartile range (IQR) increases in PM2.5, BC, UFP, and AMP concentrations were generally associated with increased CRP and fibrinogen, but not PF4, D-dimer, vWF, or P-selectin. Adenosine Monophosphate 59-62 fibrinogen beta chain Homo sapiens 127-137 28121179-7 2017 By combining the two factors, we developed a novel index, fibrinogen-cholesterol (FC) score and found it to have better prognostic accuracy than the two factors alone. Cholesterol 69-80 fibrinogen beta chain Homo sapiens 58-68 28350862-6 2017 De novo synthesis of albumin and fibrinogen by the incorporation of D5-phenylalanine or D8-phenylalanine were measured using the flooding dose technique. d5-phenylalanine 68-84 fibrinogen beta chain Homo sapiens 33-43 28350862-6 2017 De novo synthesis of albumin and fibrinogen by the incorporation of D5-phenylalanine or D8-phenylalanine were measured using the flooding dose technique. d8-phenylalanine 88-104 fibrinogen beta chain Homo sapiens 33-43 28112519-0 2017 Effect of Network Density in Surface-Anchored Poly(N-isopropylacrylamide) Hydrogels on Adsorption of Fibrinogen. poly-N-isopropylacrylamide 46-73 fibrinogen beta chain Homo sapiens 101-111 28127605-2 2017 Here, we used the nanopores of poly(methyl methacrylate) films to attach fibrinogen and lysozyme, and discussed the changes in proteins" structures and elasticity upon confinement. Polymethyl Methacrylate 31-56 fibrinogen beta chain Homo sapiens 73-83 29296957-2 2017 The interaction between the fibrinogen C-terminal gamma-chain peptide composed of residues gamma-404-411 (GAKQAGDV) and the Arg-Gly-Asp (RGD) binding pocket on alphaIIbbeta3 is required for fibrinogen-mediated platelet aggregation, but data suggest that other ancillary binding sites on both fibrinogen and alphaIIbbeta3 may lead to higher-affinity fibrinogen binding and clot retraction. Arginine 124-127 fibrinogen beta chain Homo sapiens 28-38 29296957-2 2017 The interaction between the fibrinogen C-terminal gamma-chain peptide composed of residues gamma-404-411 (GAKQAGDV) and the Arg-Gly-Asp (RGD) binding pocket on alphaIIbbeta3 is required for fibrinogen-mediated platelet aggregation, but data suggest that other ancillary binding sites on both fibrinogen and alphaIIbbeta3 may lead to higher-affinity fibrinogen binding and clot retraction. Arginine 124-127 fibrinogen beta chain Homo sapiens 190-200 29296957-2 2017 The interaction between the fibrinogen C-terminal gamma-chain peptide composed of residues gamma-404-411 (GAKQAGDV) and the Arg-Gly-Asp (RGD) binding pocket on alphaIIbbeta3 is required for fibrinogen-mediated platelet aggregation, but data suggest that other ancillary binding sites on both fibrinogen and alphaIIbbeta3 may lead to higher-affinity fibrinogen binding and clot retraction. Arginine 124-127 fibrinogen beta chain Homo sapiens 190-200 29296957-2 2017 The interaction between the fibrinogen C-terminal gamma-chain peptide composed of residues gamma-404-411 (GAKQAGDV) and the Arg-Gly-Asp (RGD) binding pocket on alphaIIbbeta3 is required for fibrinogen-mediated platelet aggregation, but data suggest that other ancillary binding sites on both fibrinogen and alphaIIbbeta3 may lead to higher-affinity fibrinogen binding and clot retraction. Arginine 124-127 fibrinogen beta chain Homo sapiens 190-200 29296957-2 2017 The interaction between the fibrinogen C-terminal gamma-chain peptide composed of residues gamma-404-411 (GAKQAGDV) and the Arg-Gly-Asp (RGD) binding pocket on alphaIIbbeta3 is required for fibrinogen-mediated platelet aggregation, but data suggest that other ancillary binding sites on both fibrinogen and alphaIIbbeta3 may lead to higher-affinity fibrinogen binding and clot retraction. Glycine 128-131 fibrinogen beta chain Homo sapiens 28-38 29296957-2 2017 The interaction between the fibrinogen C-terminal gamma-chain peptide composed of residues gamma-404-411 (GAKQAGDV) and the Arg-Gly-Asp (RGD) binding pocket on alphaIIbbeta3 is required for fibrinogen-mediated platelet aggregation, but data suggest that other ancillary binding sites on both fibrinogen and alphaIIbbeta3 may lead to higher-affinity fibrinogen binding and clot retraction. Glycine 128-131 fibrinogen beta chain Homo sapiens 190-200 29296957-2 2017 The interaction between the fibrinogen C-terminal gamma-chain peptide composed of residues gamma-404-411 (GAKQAGDV) and the Arg-Gly-Asp (RGD) binding pocket on alphaIIbbeta3 is required for fibrinogen-mediated platelet aggregation, but data suggest that other ancillary binding sites on both fibrinogen and alphaIIbbeta3 may lead to higher-affinity fibrinogen binding and clot retraction. Glycine 128-131 fibrinogen beta chain Homo sapiens 190-200 29296957-2 2017 The interaction between the fibrinogen C-terminal gamma-chain peptide composed of residues gamma-404-411 (GAKQAGDV) and the Arg-Gly-Asp (RGD) binding pocket on alphaIIbbeta3 is required for fibrinogen-mediated platelet aggregation, but data suggest that other ancillary binding sites on both fibrinogen and alphaIIbbeta3 may lead to higher-affinity fibrinogen binding and clot retraction. Glycine 128-131 fibrinogen beta chain Homo sapiens 190-200 29296957-2 2017 The interaction between the fibrinogen C-terminal gamma-chain peptide composed of residues gamma-404-411 (GAKQAGDV) and the Arg-Gly-Asp (RGD) binding pocket on alphaIIbbeta3 is required for fibrinogen-mediated platelet aggregation, but data suggest that other ancillary binding sites on both fibrinogen and alphaIIbbeta3 may lead to higher-affinity fibrinogen binding and clot retraction. Aspartic Acid 132-135 fibrinogen beta chain Homo sapiens 28-38 29296957-2 2017 The interaction between the fibrinogen C-terminal gamma-chain peptide composed of residues gamma-404-411 (GAKQAGDV) and the Arg-Gly-Asp (RGD) binding pocket on alphaIIbbeta3 is required for fibrinogen-mediated platelet aggregation, but data suggest that other ancillary binding sites on both fibrinogen and alphaIIbbeta3 may lead to higher-affinity fibrinogen binding and clot retraction. Aspartic Acid 132-135 fibrinogen beta chain Homo sapiens 190-200 29296957-2 2017 The interaction between the fibrinogen C-terminal gamma-chain peptide composed of residues gamma-404-411 (GAKQAGDV) and the Arg-Gly-Asp (RGD) binding pocket on alphaIIbbeta3 is required for fibrinogen-mediated platelet aggregation, but data suggest that other ancillary binding sites on both fibrinogen and alphaIIbbeta3 may lead to higher-affinity fibrinogen binding and clot retraction. Aspartic Acid 132-135 fibrinogen beta chain Homo sapiens 190-200 29296957-2 2017 The interaction between the fibrinogen C-terminal gamma-chain peptide composed of residues gamma-404-411 (GAKQAGDV) and the Arg-Gly-Asp (RGD) binding pocket on alphaIIbbeta3 is required for fibrinogen-mediated platelet aggregation, but data suggest that other ancillary binding sites on both fibrinogen and alphaIIbbeta3 may lead to higher-affinity fibrinogen binding and clot retraction. Aspartic Acid 132-135 fibrinogen beta chain Homo sapiens 190-200 27769916-8 2017 Fibrinogen and IL-6 increased post-stress (p<=0.001 & 0.003) but TNFalpha was unchanged (p=0.09). Adenosine Monophosphate 56-59 fibrinogen beta chain Homo sapiens 0-10 27738342-8 2017 Patients with low fibrinogen level (<340mg/dl) had significantly longer CSS and the different survival rate were defined using the log-rank test. thiocysteine 75-78 fibrinogen beta chain Homo sapiens 18-28 27738342-10 2017 Fibrinogen may serve as a powerful predictor of CSS in penile cancer patients. thiocysteine 48-51 fibrinogen beta chain Homo sapiens 0-10 27771529-7 2017 In healthy women, ethinyl estradiol plus drospirenone increased plasma levels of insulin, hsCRP, fibrinogen and homocysteine, while in women with elevated androgen levels their effect was limited only to a small increase in hsCRP. drospirenone 41-53 fibrinogen beta chain Homo sapiens 97-107 26919276-10 2017 The in silico and spectrofluorometric studies also showed interaction of Bacifrinase with thrombin as well as fibrinogen with a Kd value of 16.5 and .81 nM, respectively. bacifrinase 73-84 fibrinogen beta chain Homo sapiens 110-120 27771529-7 2017 In healthy women, ethinyl estradiol plus drospirenone increased plasma levels of insulin, hsCRP, fibrinogen and homocysteine, while in women with elevated androgen levels their effect was limited only to a small increase in hsCRP. Ethinyl Estradiol 18-35 fibrinogen beta chain Homo sapiens 97-107 26919276-0 2017 An in silico approach to understand the structure-function properties of a serine protease (Bacifrinase) from Bacillus cereus and experimental evidence to support the interaction of Bacifrinase with fibrinogen and thrombin. bacifrinase 92-103 fibrinogen beta chain Homo sapiens 199-209 27755007-4 2017 RESULTS: Fibrinogen showed a tendency toward a positive association with PB [beta (95% CI): 2.55 (-0.52-5.61) increase in PB per ln(g/l) fibrinogen, P=0.09], which was driven significantly by an association in the ACS subgroup [beta (95% CI): 4.11 (0.01-8.21) increase in PB per ln(g/l) fibrinogen, P=0.049]. pladienolide B 73-75 fibrinogen beta chain Homo sapiens 9-19 28104989-5 2017 RESULTS: SES-CD correlated significantly with CD clinical activity and several standard biochemical parameters (albumin, leukocyte and platelet counts, C-reactive protein, erythrocyte sedimentation rate, fibrinogen). ses-cd 9-15 fibrinogen beta chain Homo sapiens 204-214 28249913-9 2017 After 6 months of L-T4 treatment, a significant decrease in FIB, PAI-1 and t-PA levels and an increase in APTT and DDI were observed in the severe SH group. Thyroxine 18-22 fibrinogen beta chain Homo sapiens 60-63 27777179-17 2017 In particular, our work highlights how fibrinogen is an important constituent of HOCl-induced HMW protein aggregates validating the mass spectrometry result with additional experiments. Hypochlorous Acid 81-85 fibrinogen beta chain Homo sapiens 39-49 27929198-1 2017 Both type 2 diabetes (T2DM) and Bbeta448Lys variant of fibrinogen are associated with dense fibrin clots, impaired fibrinolysis and increased cardiovascular risk. bbeta448lys 32-43 fibrinogen beta chain Homo sapiens 55-65 27929198-8 2017 Clots made from plasma-purified fibrinogen of individuals with Arg/Arg, Arg/Lys and Lys/Lys genotypes showed differences in fibre thickness (46.75 +- 8.07, 38.40 +- 6.04 and 25 +- 4.99 nm, respectively; p<0.001) and clot lysis time (419 +- 64, 442 +- 87 and 517 +- 65 s, respectively; p=0.02), directly implicating the polymorphism in the observed changes. Arginine 63-66 fibrinogen beta chain Homo sapiens 32-42 27929198-8 2017 Clots made from plasma-purified fibrinogen of individuals with Arg/Arg, Arg/Lys and Lys/Lys genotypes showed differences in fibre thickness (46.75 +- 8.07, 38.40 +- 6.04 and 25 +- 4.99 nm, respectively; p<0.001) and clot lysis time (419 +- 64, 442 +- 87 and 517 +- 65 s, respectively; p=0.02), directly implicating the polymorphism in the observed changes. Arginine 67-70 fibrinogen beta chain Homo sapiens 32-42 27929198-8 2017 Clots made from plasma-purified fibrinogen of individuals with Arg/Arg, Arg/Lys and Lys/Lys genotypes showed differences in fibre thickness (46.75 +- 8.07, 38.40 +- 6.04 and 25 +- 4.99 nm, respectively; p<0.001) and clot lysis time (419 +- 64, 442 +- 87 and 517 +- 65 s, respectively; p=0.02), directly implicating the polymorphism in the observed changes. Arginine 67-70 fibrinogen beta chain Homo sapiens 32-42 27929198-8 2017 Clots made from plasma-purified fibrinogen of individuals with Arg/Arg, Arg/Lys and Lys/Lys genotypes showed differences in fibre thickness (46.75 +- 8.07, 38.40 +- 6.04 and 25 +- 4.99 nm, respectively; p<0.001) and clot lysis time (419 +- 64, 442 +- 87 and 517 +- 65 s, respectively; p=0.02), directly implicating the polymorphism in the observed changes. Lysine 76-79 fibrinogen beta chain Homo sapiens 32-42 27929198-8 2017 Clots made from plasma-purified fibrinogen of individuals with Arg/Arg, Arg/Lys and Lys/Lys genotypes showed differences in fibre thickness (46.75 +- 8.07, 38.40 +- 6.04 and 25 +- 4.99 nm, respectively; p<0.001) and clot lysis time (419 +- 64, 442 +- 87 and 517 +- 65 s, respectively; p=0.02), directly implicating the polymorphism in the observed changes. Lysine 84-87 fibrinogen beta chain Homo sapiens 32-42 27929198-8 2017 Clots made from plasma-purified fibrinogen of individuals with Arg/Arg, Arg/Lys and Lys/Lys genotypes showed differences in fibre thickness (46.75 +- 8.07, 38.40 +- 6.04 and 25 +- 4.99 nm, respectively; p<0.001) and clot lysis time (419 +- 64, 442 +- 87 and 517 +- 65 s, respectively; p=0.02), directly implicating the polymorphism in the observed changes. Lysine 84-87 fibrinogen beta chain Homo sapiens 32-42 28086966-6 2017 The remnant cholesterol associated with high sensitivity C-reactive protein, neutrophil count and fibrinogen (R 2 = 0.20, 0.12 and 0.14; P = 0.000, 0.036 and 0.010 respectively). Cholesterol 12-23 fibrinogen beta chain Homo sapiens 98-108 27281365-11 2017 Another contributing factor to carcinogenesis is the excessive consumption of red meat containing redox-active iron (Fe+3) that initiates parafibrin formation from blood fibrinogen. Iron 111-115 fibrinogen beta chain Homo sapiens 170-180 27281365-11 2017 Another contributing factor to carcinogenesis is the excessive consumption of red meat containing redox-active iron (Fe+3) that initiates parafibrin formation from blood fibrinogen. Iron 117-119 fibrinogen beta chain Homo sapiens 170-180 27755007-4 2017 RESULTS: Fibrinogen showed a tendency toward a positive association with PB [beta (95% CI): 2.55 (-0.52-5.61) increase in PB per ln(g/l) fibrinogen, P=0.09], which was driven significantly by an association in the ACS subgroup [beta (95% CI): 4.11 (0.01-8.21) increase in PB per ln(g/l) fibrinogen, P=0.049]. pladienolide B 73-75 fibrinogen beta chain Homo sapiens 137-147 27755007-4 2017 RESULTS: Fibrinogen showed a tendency toward a positive association with PB [beta (95% CI): 2.55 (-0.52-5.61) increase in PB per ln(g/l) fibrinogen, P=0.09], which was driven significantly by an association in the ACS subgroup [beta (95% CI): 4.11 (0.01-8.21) increase in PB per ln(g/l) fibrinogen, P=0.049]. pladienolide B 73-75 fibrinogen beta chain Homo sapiens 287-297 27755007-4 2017 RESULTS: Fibrinogen showed a tendency toward a positive association with PB [beta (95% CI): 2.55 (-0.52-5.61) increase in PB per ln(g/l) fibrinogen, P=0.09], which was driven significantly by an association in the ACS subgroup [beta (95% CI): 4.11 (0.01-8.21) increase in PB per ln(g/l) fibrinogen, P=0.049]. pladienolide B 122-124 fibrinogen beta chain Homo sapiens 9-19 27755007-5 2017 Fibrinogen was also related to the presence of lesions with PB 70% or more in both the full cohort [OR (95% CI): 2.27 (1.17-4.43), P=0.016] and ACS patients [OR (95% CI): 2.92 (1.17-7.29), P=0.022]. pladienolide B 60-62 fibrinogen beta chain Homo sapiens 0-10 28243182-9 2017 Laquinimod was also associated with asymptomatic changes in liver enzyme levels, fibrinogen levels, and hematologic parameters that followed a consistent temporal pattern: mild, nonprogressive, and occurring within 90 days of treatment initiation, then stabilizing or reverting to baseline levels during continued treatment. laquinimod 0-10 fibrinogen beta chain Homo sapiens 81-91 27448541-0 2016 Antibody functionalized graphene biosensor for label-free electrochemical immunosensing of fibrinogen, an indicator of trauma induced coagulopathy. Graphite 24-32 fibrinogen beta chain Homo sapiens 91-101 30196004-0 2017 [Studies on the Interaction of Poly-L-lysine with Fibrinogen with Spectroscopic Methods]. Lysine 31-44 fibrinogen beta chain Homo sapiens 50-60 30196004-3 2017 Therefore, it is of certain innovation to further evaluate the blood compatibility of poly-L-lysine, which is studied by the interaction between poly-L-lysine and fibrinogen with many spectroscopic methods. Lysine 86-99 fibrinogen beta chain Homo sapiens 163-173 30196004-4 2017 In this study, the fluorescence, ultraviolet visible and circular dichroism spectroscopy were used to research the effects of poly-L-lysine on the structure of fibrinogen. Lysine 126-139 fibrinogen beta chain Homo sapiens 160-170 30196004-8 2017 Ultraviolet visible spectra showed that the absorption intensity of fibrinogen at 200~240 and 278 nm, which was less affected by 0.025 mg mL(-1) poly-L-lysine, reduced with the concentration of poly-L-lysine increasing. Lysine 145-158 fibrinogen beta chain Homo sapiens 68-78 30196004-8 2017 Ultraviolet visible spectra showed that the absorption intensity of fibrinogen at 200~240 and 278 nm, which was less affected by 0.025 mg mL(-1) poly-L-lysine, reduced with the concentration of poly-L-lysine increasing. Lysine 194-207 fibrinogen beta chain Homo sapiens 68-78 30196004-9 2017 Circular dichroism spectra showed when the concentration of poly-L-lysine increased, the effect of poly-L-lysine on the secondary structure of fibrinogen strengthened. Lysine 60-73 fibrinogen beta chain Homo sapiens 143-153 28751821-3 2017 In view of the multiplicity of citrullinated autoantigens described as ACPA targets, we generated a multiepitope citrullinated peptide (Cit-ME) from the sequences of major citrullinated autoantigens: filaggrin, beta-fibrinogen, vimentin, and collagen type II. cit-me 136-142 fibrinogen beta chain Homo sapiens 211-226 30196004-9 2017 Circular dichroism spectra showed when the concentration of poly-L-lysine increased, the effect of poly-L-lysine on the secondary structure of fibrinogen strengthened. Lysine 99-112 fibrinogen beta chain Homo sapiens 143-153 30196004-10 2017 Overall, as the concentration of poly-L-lysine increased, the alpha-helix content of fibrinogen decreased and the beta-fold, beta-turn and random coil content of fibrinogen increased. Lysine 33-46 fibrinogen beta chain Homo sapiens 85-95 30196004-10 2017 Overall, as the concentration of poly-L-lysine increased, the alpha-helix content of fibrinogen decreased and the beta-fold, beta-turn and random coil content of fibrinogen increased. Lysine 33-46 fibrinogen beta chain Homo sapiens 162-172 30196004-11 2017 These results showed that the electrostatic interaction was occurred between poly-L-lysine and fibrinogen, which influenced the structure of fibrinogen by concentration dependence. Lysine 77-90 fibrinogen beta chain Homo sapiens 95-105 30196004-11 2017 These results showed that the electrostatic interaction was occurred between poly-L-lysine and fibrinogen, which influenced the structure of fibrinogen by concentration dependence. Lysine 77-90 fibrinogen beta chain Homo sapiens 141-151 30196004-12 2017 While the effect of poly-L-lysine (0.01 and 0.025 mg mL(-1)) on fibrinogen was little, poly-L-lysine of high concentration would damage the physiological function of fibrinogen. Lysine 87-100 fibrinogen beta chain Homo sapiens 166-176 32263777-4 2016 The results of platelet adhesion, activation, fibrinogen denaturation, and whole blood dynamic adhesion testing indicated that the PCDLOPTPT@Ti coating presented a better hemocompatibility when compared with bare Ti and other control samples. pcdloptpt 131-140 fibrinogen beta chain Homo sapiens 46-56 27448541-1 2016 An antibody, specific to fibrinogen, has been covalently attached to graphene and deposited onto screen printed electrodes using a chitosan hydrogel binder to prepare an inexpensive electrochemical fibrinogen biosensor. Graphite 69-77 fibrinogen beta chain Homo sapiens 25-35 33465887-0 2016 Interfacial Structures and Fibrinogen Adsorption at Blood-Compatible Polymer/Water Interfaces. Polymers 69-76 fibrinogen beta chain Homo sapiens 27-37 33465887-0 2016 Interfacial Structures and Fibrinogen Adsorption at Blood-Compatible Polymer/Water Interfaces. Water 77-82 fibrinogen beta chain Homo sapiens 27-37 27610454-3 2016 Polymerisation of fibrinogen with thrombin and CaCl2 was studied using spinning disk confocal (SDC) microscopy. Calcium Chloride 47-52 fibrinogen beta chain Homo sapiens 18-28 27956676-10 2016 Plasma fibrinogen concentrations remained higher in the FC group up to 12 h after admission with the largest difference at three h (2.9 mg dL - 1 vs. 1.8 mg dL - 1; P<0.01). Fc(alpha) receptor 56-58 fibrinogen beta chain Homo sapiens 7-17 27775351-0 2016 pH-Dependent Ordered Fibrinogen Adsorption on Polyethylene Single Crystals. Polyethylene 46-58 fibrinogen beta chain Homo sapiens 21-31 27424313-12 2016 Otherwise, combination and fenofibrate significantly reduced apolipoprotein B and non-HDL cholesterol and improved flow-mediated dilation and reduced CRP and fibrinogen to a similar extent. Fenofibrate 27-38 fibrinogen beta chain Homo sapiens 158-168 27906052-11 2016 However, association was observed between the PTPN22 risk allele and positivity to cit-Fib alpha-35 and cit-Fib alpha-263,271. cit 83-86 fibrinogen beta chain Homo sapiens 87-90 27702872-3 2016 In the present study, we investigated the influence of oxidative stress of fibrinogen induced by H2O2 on the polymerization state of fibrin. Hydrogen Peroxide 97-101 fibrinogen beta chain Homo sapiens 75-85 27717074-7 2016 Men with vitamin D deficiency or insufficiency effectively treated with vitamin D preparations were characterized by decreased insulin sensitivity and higher circulating levels of hsCRP, homocysteine, and fibrinogen in comparison with the remaining groups of patients. Vitamin D 9-18 fibrinogen beta chain Homo sapiens 205-215 27717074-7 2016 Men with vitamin D deficiency or insufficiency effectively treated with vitamin D preparations were characterized by decreased insulin sensitivity and higher circulating levels of hsCRP, homocysteine, and fibrinogen in comparison with the remaining groups of patients. Vitamin D 72-81 fibrinogen beta chain Homo sapiens 205-215 27717074-8 2016 Although atorvastatin decreased plasma levels of total cholesterol and LDL-C to a similar extent in all study groups, its effect on uric acid, hsCRP, homocysteine, and fibrinogen was more pronounced in patients from groups B and C than in men from group A. Atorvastatin 9-21 fibrinogen beta chain Homo sapiens 168-178 29634116-0 2016 COMMERCIAL EXTRACT FROM ARONIA AS A MODULATOR OF ADHESIVE PROPERTIES OF FIBRINOGEN TREATED WITH HOMOCYSTEINE AND ITS THIOLACTONE IN VITRO. Homocysteine 96-108 fibrinogen beta chain Homo sapiens 72-82 29634116-0 2016 COMMERCIAL EXTRACT FROM ARONIA AS A MODULATOR OF ADHESIVE PROPERTIES OF FIBRINOGEN TREATED WITH HOMOCYSTEINE AND ITS THIOLACTONE IN VITRO. Thiolactone 117-128 fibrinogen beta chain Homo sapiens 72-82 29634116-2 2016 The protective effects of polyphenol-rich extract from berries of A. melanocarpa against changes in biological properties of fibrinogen were studied. Polyphenols 26-36 fibrinogen beta chain Homo sapiens 125-135 29634116-8 2016 The experiments also indicate that polyphenol-rich extract from black chokeberries (at final concentrations of 2.5-10 pM/mL) reduced the toxic action of Hey and HTL on the adhesive properties of fibrinogen. Polyphenols 35-45 fibrinogen beta chain Homo sapiens 195-205 27710858-0 2016 Novel FGB mutation Bbeta240Cys Arg confirms importance of the Bbeta211-240 disulphide for plasma expression of fibrinogen. Arginine 31-34 fibrinogen beta chain Homo sapiens 6-9 27710858-0 2016 Novel FGB mutation Bbeta240Cys Arg confirms importance of the Bbeta211-240 disulphide for plasma expression of fibrinogen. Arginine 31-34 fibrinogen beta chain Homo sapiens 111-121 27710858-0 2016 Novel FGB mutation Bbeta240Cys Arg confirms importance of the Bbeta211-240 disulphide for plasma expression of fibrinogen. disulphide 75-85 fibrinogen beta chain Homo sapiens 6-9 27710858-0 2016 Novel FGB mutation Bbeta240Cys Arg confirms importance of the Bbeta211-240 disulphide for plasma expression of fibrinogen. disulphide 75-85 fibrinogen beta chain Homo sapiens 111-121 27311701-8 2016 Three real-world applications with monotone missing patterns are provided, namely, the association between (1) the fibrinogen level and coronary heart disease, (2) the intima media thickness and vascular risk and (3) allergic asthma and depressive episodes. monotone 35-43 fibrinogen beta chain Homo sapiens 115-125 27254464-0 2016 Adsorption and conformational modification of fibronectin and fibrinogen adsorbed on hydroxyapatite. Durapatite 85-99 fibrinogen beta chain Homo sapiens 62-72 26780664-8 2016 In a subgroup analysis of the elevated preoperative plasma fibrinogen level group, postoperative normalisation of plasma fibrinogen level was significantly associated with CSS, showing that patients with non-normalised plasma fibrinogen levels tended to have a higher incidence of cancer-specific mortality after surgery. thiocysteine 172-175 fibrinogen beta chain Homo sapiens 59-69 26780664-8 2016 In a subgroup analysis of the elevated preoperative plasma fibrinogen level group, postoperative normalisation of plasma fibrinogen level was significantly associated with CSS, showing that patients with non-normalised plasma fibrinogen levels tended to have a higher incidence of cancer-specific mortality after surgery. thiocysteine 172-175 fibrinogen beta chain Homo sapiens 121-131 26780664-8 2016 In a subgroup analysis of the elevated preoperative plasma fibrinogen level group, postoperative normalisation of plasma fibrinogen level was significantly associated with CSS, showing that patients with non-normalised plasma fibrinogen levels tended to have a higher incidence of cancer-specific mortality after surgery. thiocysteine 172-175 fibrinogen beta chain Homo sapiens 121-131 27867333-9 2016 In a multivariate regression analysis model adjusted for the age of subjects, BMI, marital status, smoking, snuff, and alcohol intake with serum levels of PSA as a dependent variable, serum level of fibrinogen predicted higher PSA-values (odds ratio = 3.30, 95% CI = 1.05-10.20, p = 0.042). Alcohols 119-126 fibrinogen beta chain Homo sapiens 199-209 27561317-3 2016 We recently detected reduced binding of FXIII-A2B2 to murine fibrinogen that has gamma-chain residues 390-396 mutated to alanines (Fibgamma390-396A). Alanine 121-129 fibrinogen beta chain Homo sapiens 61-71 26893443-0 2016 Intraoperative Hydroxyethyl Starch and its Effects on Different Fibrinogen Measurements. Hydroxyethyl starch 15-34 fibrinogen beta chain Homo sapiens 64-74 26893443-1 2016 BACKGROUND: Intravenous fluids with synthetic colloids such as hydroxyethyl starch (HES) are known to interfere with plasma fibrinogen concentration measurements. Hydroxyethyl starch 63-82 fibrinogen beta chain Homo sapiens 124-134 26893443-1 2016 BACKGROUND: Intravenous fluids with synthetic colloids such as hydroxyethyl starch (HES) are known to interfere with plasma fibrinogen concentration measurements. Hydroxyethyl Starch Derivatives 84-87 fibrinogen beta chain Homo sapiens 124-134 26893443-11 2016 CONCLUSION: Despite providing different fibrinogen concentration values at baseline, the relative decrease in fibrinogen concentration after HES infusion was comparable among the 3 tests. Hydroxyethyl Starch Derivatives 141-144 fibrinogen beta chain Homo sapiens 110-120 26893443-12 2016 In contrast, fibrin-based clot quality was more affected than fibrinogen concentration tests by HES infusion. Hydroxyethyl Starch Derivatives 96-99 fibrinogen beta chain Homo sapiens 62-72 27496722-6 2016 Significant improvements in recording of lactate and fibrinogen were demonstrated, both on admission (lactate - p<0.000, fibrinogen - p=0.015), and preoperatively (lactate - p=0.003, fibrinogen - p=0.030). Lactic Acid 102-109 fibrinogen beta chain Homo sapiens 53-63 27496722-6 2016 Significant improvements in recording of lactate and fibrinogen were demonstrated, both on admission (lactate - p<0.000, fibrinogen - p=0.015), and preoperatively (lactate - p=0.003, fibrinogen - p=0.030). Lactic Acid 102-109 fibrinogen beta chain Homo sapiens 53-63 27254464-4 2016 In this work, the adsorption and conformational changes of two fibroid serum proteins; fibronectin and fibrinogen adsorbed onto four different hydroxyapatite powders are studied with a Quartz Crystal Microbalance with Dissipation (QCM-D). Durapatite 143-157 fibrinogen beta chain Homo sapiens 103-113 27514025-8 2016 Methods Fibrinogen proteolysis was characterized using SDS PAGE and liquid chromatography-tandem mass spectrometry (LC-MS/MS). Sodium Dodecyl Sulfate 55-58 fibrinogen beta chain Homo sapiens 8-18 26306738-7 2016 In IBC group, pre-treatment MPV level associated, significantly, with clinical hematology parameters (platelet, fibrinogen, albumin, fasting blood glucose, P = 0.003, 0.042, 0.032, 0.046, respectively) and with clinicopathological parameters (distant metastasis, primary tumor size, tumor node metastasis stages, P = 0.039, 0.002, 0.001, respectively). Bucrylate 3-6 fibrinogen beta chain Homo sapiens 112-122 27172157-8 2016 RESULTS: Fibrinogen in plasma and its extravasation to muscles significantly increased in BI versus SB mice. Antimony 100-102 fibrinogen beta chain Homo sapiens 9-19 27172157-9 2016 Fibrinogen applied to myotubes evoked inflammatory responses (increased MCP-1 and TNF-alpha; 32.6 and 3.9-fold, respectively) and reduced MMP; these changes were ameliorated by glycyrrhizin treatment. Glycyrrhizic Acid 177-189 fibrinogen beta chain Homo sapiens 0-10 27172157-11 2016 CONCLUSIONS: Inflammatory responses and MMP loss in myotubes induced by fibrinogen were reversed by glycyrrhizin. Glycyrrhizic Acid 100-112 fibrinogen beta chain Homo sapiens 72-82 27117175-4 2016 RESULTS: Compared with T1, the fibrinogen and MA levels in both groups reduced significantly after heparin reversal and fell within the normal range for most patients. Heparin 99-106 fibrinogen beta chain Homo sapiens 31-41 27117175-8 2016 CONCLUSION: Most patients receiving aortic arch replacement with DHCA have normal platelet function and fibrinogen levels after heparin reversal. Heparin 128-135 fibrinogen beta chain Homo sapiens 104-114 27153116-7 2016 Additionally, using bovine serum albumin and fibrinogen as model proteins, the protein adsorption determined with quartz crystal microbalance showed that the l-selenocystine immobilized surface enhanced protein adsorption. selenocystine 158-173 fibrinogen beta chain Homo sapiens 45-55 27343352-6 2016 After the loose of its partner in Bbeta-chain, the gammaCys135 was probably disulfide-bridged to its corresponding Cys residue of another abnormal fibrinogen molecule, forming dimmer with an abnormal electrophoretic profile. bbeta 34-39 fibrinogen beta chain Homo sapiens 147-157 27343352-6 2016 After the loose of its partner in Bbeta-chain, the gammaCys135 was probably disulfide-bridged to its corresponding Cys residue of another abnormal fibrinogen molecule, forming dimmer with an abnormal electrophoretic profile. gammacys135 51-62 fibrinogen beta chain Homo sapiens 147-157 27343352-6 2016 After the loose of its partner in Bbeta-chain, the gammaCys135 was probably disulfide-bridged to its corresponding Cys residue of another abnormal fibrinogen molecule, forming dimmer with an abnormal electrophoretic profile. Disulfides 76-85 fibrinogen beta chain Homo sapiens 147-157 27343352-6 2016 After the loose of its partner in Bbeta-chain, the gammaCys135 was probably disulfide-bridged to its corresponding Cys residue of another abnormal fibrinogen molecule, forming dimmer with an abnormal electrophoretic profile. Cysteine 56-59 fibrinogen beta chain Homo sapiens 147-157 27576312-11 2016 Higher fibrinogen levels on admission were associated with smaller clot burden (p = 0.033) and lower NIHSS on admission (p = 0.022). nihss 101-106 fibrinogen beta chain Homo sapiens 7-17 27262026-8 2016 Fibrinogen also attenuated Abeta-induced platelet responses like secretion, clot retraction, rise in cytosolic Ca+2 and reactive oxygen species (ROS). Reactive Oxygen Species 120-143 fibrinogen beta chain Homo sapiens 0-10 27262026-8 2016 Fibrinogen also attenuated Abeta-induced platelet responses like secretion, clot retraction, rise in cytosolic Ca+2 and reactive oxygen species (ROS). Reactive Oxygen Species 145-148 fibrinogen beta chain Homo sapiens 0-10 27520927-0 2016 Fibrinogen storage disease in a Chinese boy with de novo fibrinogen Aguadilla mutation: Incomplete response to carbamazepine and ursodeoxycholic acid. Carbamazepine 111-124 fibrinogen beta chain Homo sapiens 57-67 27462904-0 2016 Surface Assembly Configurations and Packing Preferences of Fibrinogen Mediated by the Periodicity and Alignment Control of Block Copolymer Nanodomains. copolymer 129-138 fibrinogen beta chain Homo sapiens 59-69 27324768-8 2016 Independent covariates related to significant decreases of linezolid concentrations included higher weight, creatinine clearance rates, and fibrinogen and antithrombin concentrations, lower concentrations of lactate, and the presence of acute respiratory distress syndrome (ARDS). Linezolid 59-68 fibrinogen beta chain Homo sapiens 140-150 27324768-9 2016 Linezolid clearance was increased in ARDS patients (by 82%) and in patients with elevated fibrinogen or decreased lactate concentrations. Linezolid 0-9 fibrinogen beta chain Homo sapiens 90-100 27520927-0 2016 Fibrinogen storage disease in a Chinese boy with de novo fibrinogen Aguadilla mutation: Incomplete response to carbamazepine and ursodeoxycholic acid. Ursodeoxycholic Acid 129-149 fibrinogen beta chain Homo sapiens 57-67 27540305-15 2016 When we used both the NLR and fibrinogen level to distinguish between the MIBC and NMIBC, sensitivity was found to be 86%, and specificity was 42%. 4-METHYL-2-PENTANOL 74-78 fibrinogen beta chain Homo sapiens 30-40 27540305-15 2016 When we used both the NLR and fibrinogen level to distinguish between the MIBC and NMIBC, sensitivity was found to be 86%, and specificity was 42%. nmibc 83-88 fibrinogen beta chain Homo sapiens 30-40 26905070-6 2016 In plasma containing iron and carbon monoxide modified fibrinogen, which may be found in patients at risk of stroke, the coagulation kinetic differences observed with venom was still more vigorous than that seen with thrombin. Carbon Monoxide 30-45 fibrinogen beta chain Homo sapiens 55-65 26880105-6 2016 Nine patients in the saline group (20.9%) required fibrinogen at graft reperfusion (compared with one patient [2.1%] in the fibrinogen group; p = 0.005). Sodium Chloride 21-27 fibrinogen beta chain Homo sapiens 51-61 26249791-10 2016 RISTOMED diet supplemented with d-Limonene resulted in a decrease in fibrinogen, glucose, insulin levels and HOMA-IR. Limonene 32-42 fibrinogen beta chain Homo sapiens 69-79 27208169-7 2016 Here we show the existence of a proteostasis imbalance in ATTR linked to fibrinogen glycation by methylglyoxal. Pyruvaldehyde 97-110 fibrinogen beta chain Homo sapiens 73-83 27192476-2 2016 We hypothesized that human fibrinogen concentrate (FC) and prothrombin complex concentrate (PCC), administered as combined therapy with TXA, would provide additive effects for reducing blood loss in an animal trauma model. Tranexamic Acid 136-139 fibrinogen beta chain Homo sapiens 27-37 27244444-0 2016 Using Neutron Reflectometry to Discern the Structure of Fibrinogen Adsorption at the Stainless Steel/Aqueous Interface. Stainless Steel 85-100 fibrinogen beta chain Homo sapiens 56-66 27021032-7 2016 At multivariable analysis, fibrinogen levels lower than 220 mg/dL remained independently associated with SB (odds ratio: 2.25; 95% confidence interval: 1.54 to 3.28). Antimony 105-107 fibrinogen beta chain Homo sapiens 27-37 27164460-10 2016 The second afibrinogenemic mutation (BbetaGly295Ala) occurs in the exon 7 of the FGB gene. bbetagly295ala 37-51 fibrinogen beta chain Homo sapiens 81-84 27105953-4 2016 We used mass spectrometry of plasma from trauma patients to find that fibrinogen Aalpha-C domain methionine sulfoxide content was selectively-increased in patients with coagulopathy vs. those without coagulopathy. methionine sulfoxide 97-117 fibrinogen beta chain Homo sapiens 70-80 30695464-0 2016 [Potential Application of Fibrinogen Measurement Based on the Clauss Assay to Monitoring of Dabigatran]. Dabigatran 92-102 fibrinogen beta chain Homo sapiens 26-36 30695464-6 2016 Based on spiking experiments with another DTI, argatroban, we previously demon- strated that the discrepancy in resulting quantification of fibrinogen concentrations between two different thrombin concentrations used in the Clauss assay may enable monitoring of DTIs. argatroban 47-57 fibrinogen beta chain Homo sapiens 140-150 30695464-8 2016 The measured values of fibrinogen in the presence of dabigatran were similar to those in the absence of dabigatran when assayed using the high thrombin concentration (high-thrombin). Dabigatran 53-63 fibrinogen beta chain Homo sapiens 23-33 30695464-9 2016 The measured values of fibrinogen decreased in parallel with the increase in dabigatran concentrations when assayed using the low thrombin concentration (low-thrombin). Dabigatran 77-87 fibrinogen beta chain Homo sapiens 23-33 30695464-10 2016 Fibrinogen ratio, which is calculated by dividing the fibrinogen value measured with high- thrombin by that measured with low-thrombin, increased more sensitively at the high range of dabigatran concentrations than at the low range. Dabigatran 184-194 fibrinogen beta chain Homo sapiens 0-10 30695464-10 2016 Fibrinogen ratio, which is calculated by dividing the fibrinogen value measured with high- thrombin by that measured with low-thrombin, increased more sensitively at the high range of dabigatran concentrations than at the low range. Dabigatran 184-194 fibrinogen beta chain Homo sapiens 54-64 30695464-11 2016 Our observations suggest that the fibrinogen measurement based on the Clauss assay is practically applicable to monitoring of dabigatran especially for prediction of the bleeding risk. Dabigatran 126-136 fibrinogen beta chain Homo sapiens 34-44 27005882-3 2016 Because Ala289 plays a crucial role in maintaining the structure of the polymerization site of hole "a" via a hydrogen bond, it is speculated that the gamma 289Ala Val substitution can change not only the fibrinogen structure, but also the function of polymerization. Hydrogen 110-118 fibrinogen beta chain Homo sapiens 207-217 26969792-1 2016 Fibrinogen is extremely susceptible to attack by reactive oxygen species (ROS). Reactive Oxygen Species 49-72 fibrinogen beta chain Homo sapiens 0-10 26969792-1 2016 Fibrinogen is extremely susceptible to attack by reactive oxygen species (ROS). Reactive Oxygen Species 74-77 fibrinogen beta chain Homo sapiens 0-10 26969792-6 2016 According to the UV-absorbance and fluorescence measurements data, the employed low ozone/fibrinogen ratios have induced only a slight fibrinogen oxidative modification that was accompanied by modest chemical transformations of the aromatic amino acid residues of the protein. Amino Acids, Aromatic 232-251 fibrinogen beta chain Homo sapiens 90-100 32263312-6 2016 PNIPAM also disturbed the structure and conformation of fibrinogen. poly-N-isopropylacrylamide 0-6 fibrinogen beta chain Homo sapiens 56-66 27005882-3 2016 Because Ala289 plays a crucial role in maintaining the structure of the polymerization site of hole "a" via a hydrogen bond, it is speculated that the gamma 289Ala Val substitution can change not only the fibrinogen structure, but also the function of polymerization. Valine 166-169 fibrinogen beta chain Homo sapiens 207-217 27310988-0 2016 Association of serum calcium concentrations with fibrinogen and homocysteine in nondiabetic Korean subjects. Calcium 21-28 fibrinogen beta chain Homo sapiens 49-59 27082415-5 2016 The levels of 6-keto-prostaglandin F1alpha, fibronectin, and VEGF165 in serum were significantly upregulated by the treatment of paeonol while the levels of fibrinogen, D-dimer, and thromboxane B2 were significantly downregulated (P<0.05). paeonol 129-136 fibrinogen beta chain Homo sapiens 157-167 27310988-2 2016 This study investigated whether serum calcium, within a normal range, is significantly associated with serum fibrinogen and homocysteine, markers of increased cardiovascular disease risk in nondiabetic Korean subjects.A cross-sectional analysis was performed on 1096 subjects (mean age, 55.1 +- 11.1 years; 36.1% women) undergoing a general health checkup. Calcium 38-45 fibrinogen beta chain Homo sapiens 109-119 27229173-0 2016 Haem-assisted dityrosine-cross-linking of fibrinogen under non-thermal plasma exposure: one important mechanism of facilitated blood coagulation. dityrosine 14-24 fibrinogen beta chain Homo sapiens 42-52 26951714-12 2016 The final models built by the addition of fibrinogen improved predictive accuracy (c-index: 0.750, 0.799 and 0.767) for PFS, CSS and OS compared with the clinicopathological base models (c-index: 0.730, 0.778 and 0.746), which included Gleason score and metastasis. thiocysteine 125-128 fibrinogen beta chain Homo sapiens 42-52 26951714-13 2016 CONCLUSIONS: The pretreatment plasma fibrinogen level was associated with tumor progression and might have a significant role in the prognosis of the prostate cancer patients treated with ADT. adt 188-191 fibrinogen beta chain Homo sapiens 37-47 27229173-3 2016 The reason for the haem role is due to that its oxidized form, namely, hematin, can promote the dityrosine cross-linking of fibrinogen, the most important coagulation protein, to form a membrane-like layer on the surface of the treated blood with plasma exposure. dityrosine 96-106 fibrinogen beta chain Homo sapiens 124-134 27229173-5 2016 We confirmed that fibrinogen can coordinate with the haem iron to form a protein-haem complex which shows pseudo-peroxidase activity, and in the presence of hydrogen peroxide, the complex can induce the dityrosine formation between fibrinogen molecules, leading to the fibrin network necessary for the blood coagulation. Iron 58-62 fibrinogen beta chain Homo sapiens 18-28 27229173-5 2016 We confirmed that fibrinogen can coordinate with the haem iron to form a protein-haem complex which shows pseudo-peroxidase activity, and in the presence of hydrogen peroxide, the complex can induce the dityrosine formation between fibrinogen molecules, leading to the fibrin network necessary for the blood coagulation. Iron 58-62 fibrinogen beta chain Homo sapiens 232-242 27229173-5 2016 We confirmed that fibrinogen can coordinate with the haem iron to form a protein-haem complex which shows pseudo-peroxidase activity, and in the presence of hydrogen peroxide, the complex can induce the dityrosine formation between fibrinogen molecules, leading to the fibrin network necessary for the blood coagulation. Hydrogen Peroxide 157-174 fibrinogen beta chain Homo sapiens 232-242 27229173-5 2016 We confirmed that fibrinogen can coordinate with the haem iron to form a protein-haem complex which shows pseudo-peroxidase activity, and in the presence of hydrogen peroxide, the complex can induce the dityrosine formation between fibrinogen molecules, leading to the fibrin network necessary for the blood coagulation. dityrosine 203-213 fibrinogen beta chain Homo sapiens 18-28 27229173-5 2016 We confirmed that fibrinogen can coordinate with the haem iron to form a protein-haem complex which shows pseudo-peroxidase activity, and in the presence of hydrogen peroxide, the complex can induce the dityrosine formation between fibrinogen molecules, leading to the fibrin network necessary for the blood coagulation. dityrosine 203-213 fibrinogen beta chain Homo sapiens 232-242 27221710-4 2016 We found that synthetic monomeric Abeta40 bound through its RHDS (Arg-His-Asp-Ser) sequence to integrin alphaIIbbeta3, which is the receptor for the extracellular matrix protein fibrinogen, and stimulated the secretion of adenosine diphosphate (ADP) and the chaperone protein clusterin from platelets. Arginine 66-69 fibrinogen beta chain Homo sapiens 178-188 27221710-4 2016 We found that synthetic monomeric Abeta40 bound through its RHDS (Arg-His-Asp-Ser) sequence to integrin alphaIIbbeta3, which is the receptor for the extracellular matrix protein fibrinogen, and stimulated the secretion of adenosine diphosphate (ADP) and the chaperone protein clusterin from platelets. Histidine 70-73 fibrinogen beta chain Homo sapiens 178-188 27221710-4 2016 We found that synthetic monomeric Abeta40 bound through its RHDS (Arg-His-Asp-Ser) sequence to integrin alphaIIbbeta3, which is the receptor for the extracellular matrix protein fibrinogen, and stimulated the secretion of adenosine diphosphate (ADP) and the chaperone protein clusterin from platelets. Serine 78-81 fibrinogen beta chain Homo sapiens 178-188 26867579-8 2016 Both fibrinogen- and fibrin-alphaIIbbeta3 interactions were partially inhibited by RGD peptides, suggesting the existence of common RGD-containing binding motifs. Peptides 87-95 fibrinogen beta chain Homo sapiens 5-15 31557994-6 2016 Zn-beads saturated with human fibrinogen could bind human IgG, and Zn-beads saturated with human IgG could bind fibrinogen. Zinc 0-2 fibrinogen beta chain Homo sapiens 30-40 31557994-6 2016 Zn-beads saturated with human fibrinogen could bind human IgG, and Zn-beads saturated with human IgG could bind fibrinogen. Zinc 67-69 fibrinogen beta chain Homo sapiens 112-122 28824983-0 2016 Postoperative Heparin-Mediated Extracorporeal Low-Density Lipoprotein Fibrinogen Precipitation Aphaeresis Prevents Early Graft Occlusion after Coronary Artery Bypass Grafting. Heparin 14-21 fibrinogen beta chain Homo sapiens 70-80 28824983-5 2016 (heparin-mediated extracorporeal low-density lipoprotein [LDL] fibrinogen precipitation) aphaeresis could reduce the rate of early graft occlusion in patients with hypercholesterolemia undergoing CABG. Heparin 1-8 fibrinogen beta chain Homo sapiens 63-73 26966807-0 2016 Molecular Dynamics of Fibrinogen Adsorption onto Graphene, but Not onto Poly(ethylene glycol) Surface, Increases Exposure of Recognition Sites That Trigger Immune Response. Graphite 49-57 fibrinogen beta chain Homo sapiens 22-32 26966807-5 2016 Here we present results of explicit-solvent, all-atom MD simulations of the adsorption of the fibrinogen D-domain onto a graphene surface and a poly(ethylene glycol) (PEG) surface. Graphite 121-129 fibrinogen beta chain Homo sapiens 94-104 26966807-5 2016 Here we present results of explicit-solvent, all-atom MD simulations of the adsorption of the fibrinogen D-domain onto a graphene surface and a poly(ethylene glycol) (PEG) surface. Polyethylene Glycols 144-165 fibrinogen beta chain Homo sapiens 94-104 26782808-0 2016 Iron modulates the alpha chain of fibrinogen. Iron 0-4 fibrinogen beta chain Homo sapiens 34-44 26782808-1 2016 Iron-bound fibrinogen has been noted to accelerate plasmatic coagulation in patients with divergent conditions involving upregulation of heme oxygenase activity, including hemodialysis, Alzheimer"s disease, sickle cell anemia, and chronic migraine. Iron 0-4 fibrinogen beta chain Homo sapiens 11-21 26782808-2 2016 Our goal was to determine if a site of iron-fibrinogen interaction was on the alpha chain. Iron 39-43 fibrinogen beta chain Homo sapiens 44-54 26782808-5 2016 Iron enhances plasmatic coagulation kinetics by modulating the alpha chain of fibrinogen. Iron 0-4 fibrinogen beta chain Homo sapiens 78-88 27102694-9 2016 In the branch of regional citrate anticoagulation a higher value of functional fibrinogen is apparent. Citric Acid 26-33 fibrinogen beta chain Homo sapiens 79-89 27297894-6 2016 Analysis of the relationship between change in platelet reactivity values (dBase and dPRU) and change in fibrinogen concentration (dFg) revealed strong negative correlations: dBase = -63.3 x dFg - 27.1 (r = -0.924, p < 0.0005) and dPRU = -54.4 x dFg - 21.8 (r = -0.764, p < 0.0005). 1,3-Diphenylguanidine 131-134 fibrinogen beta chain Homo sapiens 105-115 27297894-6 2016 Analysis of the relationship between change in platelet reactivity values (dBase and dPRU) and change in fibrinogen concentration (dFg) revealed strong negative correlations: dBase = -63.3 x dFg - 27.1 (r = -0.924, p < 0.0005) and dPRU = -54.4 x dFg - 21.8 (r = -0.764, p < 0.0005). 1,3-Diphenylguanidine 191-194 fibrinogen beta chain Homo sapiens 105-115 27297894-6 2016 Analysis of the relationship between change in platelet reactivity values (dBase and dPRU) and change in fibrinogen concentration (dFg) revealed strong negative correlations: dBase = -63.3 x dFg - 27.1 (r = -0.924, p < 0.0005) and dPRU = -54.4 x dFg - 21.8 (r = -0.764, p < 0.0005). 1,3-Diphenylguanidine 191-194 fibrinogen beta chain Homo sapiens 105-115 26893405-9 2016 Both FIBTEM MCF and Clauss fibrinogen concentration yielded a good discriminative power for SB (area under the curve 0.721 and 0.767, respectively). Antimony 92-94 fibrinogen beta chain Homo sapiens 27-37 26893405-10 2016 The negative predictive value for SB was 100% for a Clauss fibrinogen concentration of 287 mg dl(-1) and 98% for an FIBTEM MCF of 14 mm. Antimony 34-36 fibrinogen beta chain Homo sapiens 59-69 26826315-5 2016 Functional binding assays demonstrated calcium ion dependent interaction of Fibulin-1 for fibrinogen, fibronectin, and Factor H. Calcium 39-46 fibrinogen beta chain Homo sapiens 90-100 27064040-14 2016 Some serologic indicators, including the level of WBC, platelet, homocysteine, ALP, positive CMV IgG antibody, fibrinogen, and some immunologic indicators, are closely related to CSSNHL. cssnhl 179-185 fibrinogen beta chain Homo sapiens 111-121 26554758-8 2016 Fibrinogen concentrations decreased by 4% and 6% (P<0.05) after consumption of 15 and 30 g alcohol, respectively. Alcohols 94-101 fibrinogen beta chain Homo sapiens 0-10 27113193-8 2016 CONCLUSION: Serum levels of D-dimer, FIB and FDP are important indicators for evaluating and predicting the effectiveness of CDT in patients with acute DVT. cdt 125-128 fibrinogen beta chain Homo sapiens 37-40 25939488-3 2016 The results showed that, with the increase of rare earth elements in WE magnesium alloys, fibrinogen adsorption decreased and coagulation function was improved. Magnesium 72-81 fibrinogen beta chain Homo sapiens 90-100 26764109-4 2016 The coating of DOF164 (low F content), which has morphology of discrete crater-type aggregates of ~ 400 nm in size, adsorbed a least amount of protein but with a highest protein unit activity as determined by SPR and immunosorbent assay; whereas the coating of DOF1612 (high F content) showed a 12.3-fold higher adsorption capacity toward Fib. dof164 15-21 fibrinogen beta chain Homo sapiens 339-342 26764109-5 2016 Interestingly, a 2.2-fold lower adsorption amount but with a 1.8-fold higher unit activity was found for Fib adsorbed on the DOF164 surface than on DOF250 (without F fraction), whose OEG segments being a widely recognized protein compatible material. dof164 125-131 fibrinogen beta chain Homo sapiens 105-108 26764109-5 2016 Interestingly, a 2.2-fold lower adsorption amount but with a 1.8-fold higher unit activity was found for Fib adsorbed on the DOF164 surface than on DOF250 (without F fraction), whose OEG segments being a widely recognized protein compatible material. dof250 148-154 fibrinogen beta chain Homo sapiens 105-108 26898623-9 2016 CONCLUSIONS: TAE plus vincristine can rapidly improve levels of platelets and fibrinogen, and it is an effective method for treatment of corticosteroid-resistant vascular tumors associated with Kasabach-Merritt phenomenon in infants. tae 13-16 fibrinogen beta chain Homo sapiens 78-88 26898623-9 2016 CONCLUSIONS: TAE plus vincristine can rapidly improve levels of platelets and fibrinogen, and it is an effective method for treatment of corticosteroid-resistant vascular tumors associated with Kasabach-Merritt phenomenon in infants. Vincristine 22-33 fibrinogen beta chain Homo sapiens 78-88 26397422-2 2016 The method relied on the interaction of fibrinogen (Fib) with AuNPs and the aggregated AuNPs induce a strong luminol-H2O2 chemiluminesecence (CL) signal. Luminol 109-116 fibrinogen beta chain Homo sapiens 40-50 27060305-3 2016 Plasma fibrinogen was extracted and analyzed with SDS-PAGE electrophoresis. Sodium Dodecyl Sulfate 50-53 fibrinogen beta chain Homo sapiens 7-17 27028649-6 2016 The fibrinogen glycation of the diabetic patients was reduced from 8.8 to 5.0 mol glucose/mol fibrinogen, and the healthy individuals had a mean fibrinogen glycation of 4.0 mol glucose/mol fibrinogen. Glucose 82-89 fibrinogen beta chain Homo sapiens 4-14 26397422-2 2016 The method relied on the interaction of fibrinogen (Fib) with AuNPs and the aggregated AuNPs induce a strong luminol-H2O2 chemiluminesecence (CL) signal. Luminol 109-116 fibrinogen beta chain Homo sapiens 52-55 26397422-2 2016 The method relied on the interaction of fibrinogen (Fib) with AuNPs and the aggregated AuNPs induce a strong luminol-H2O2 chemiluminesecence (CL) signal. Hydrogen Peroxide 117-121 fibrinogen beta chain Homo sapiens 40-50 26397422-2 2016 The method relied on the interaction of fibrinogen (Fib) with AuNPs and the aggregated AuNPs induce a strong luminol-H2O2 chemiluminesecence (CL) signal. Hydrogen Peroxide 117-121 fibrinogen beta chain Homo sapiens 52-55 26397422-4 2016 Fib was absorbed on the surface of AuNPs against the aggregation of AuNPs in 1.0M NaCl. Sodium Chloride 82-86 fibrinogen beta chain Homo sapiens 0-3 26397422-8 2016 This allows us to utilize the luminol-H2O2 CL system for quantitative analysis of thrombin, which was used to denote fibrosis degree of Fib. Luminol 30-37 fibrinogen beta chain Homo sapiens 136-139 26397422-8 2016 This allows us to utilize the luminol-H2O2 CL system for quantitative analysis of thrombin, which was used to denote fibrosis degree of Fib. Hydrogen Peroxide 38-42 fibrinogen beta chain Homo sapiens 136-139 26484645-5 2016 Compared with LMWH, dabigatran etexilate provided a similar correction of the fibrinogen level and platelet count but was less effective to reduce the D-dimer level. Dabigatran 20-40 fibrinogen beta chain Homo sapiens 78-88 26705826-0 2016 Fibrinogen adsorption mechanisms at the gold substrate revealed by QCM-D measurements and RSA modeling. rabbit sperm membrane autoantigen 90-93 fibrinogen beta chain Homo sapiens 0-10 26705826-4 2016 It was revealed that for the lower range of fibrinogen coverage the hydration function were considerably lower than previously obtained for the silica sensor [33]. Silicon Dioxide 144-150 fibrinogen beta chain Homo sapiens 44-54 26705826-3 2016 In this way, the hydration functions and water factors of fibrinogen monolayers were quantitatively evaluated at various pHs. Water 41-46 fibrinogen beta chain Homo sapiens 58-68 26453118-12 2016 Baseline plasma fibrinogen concentrations may be a readily available and inexpensive prognostic biomarker in patients with ABTC; this needs further validation in large prospective clinical trials. abtc 123-127 fibrinogen beta chain Homo sapiens 16-26 26767592-8 2016 Furthermore, our results show that incubating healthy PMPs with manganese ions (Mn(2+)), in the presence of fibrinogen, induces a major conformational change of integrin receptors, whereas thrombin activation yields a moderate response. Manganese 64-73 fibrinogen beta chain Homo sapiens 108-118 26767592-8 2016 Furthermore, our results show that incubating healthy PMPs with manganese ions (Mn(2+)), in the presence of fibrinogen, induces a major conformational change of integrin receptors, whereas thrombin activation yields a moderate response. Manganese(2+) 80-86 fibrinogen beta chain Homo sapiens 108-118 26481428-6 2016 From the spectroscopy results, the copolymers affected the local microstructure of fibrinogen. copolymers 35-45 fibrinogen beta chain Homo sapiens 83-93 26681403-10 2016 Compared with the oral placebo group, melatonin decreased the concentration of fibrinogen (Fbg) (P = 0.04) and free fatty acids (FFA) (P = 0.04) in smokers, along with the decreased expression of ICAM-1, VCAM-1 and ET-1 (P = 0.004, P = 0.001, P < 0.0001, respectively). Melatonin 38-47 fibrinogen beta chain Homo sapiens 79-89 26681403-10 2016 Compared with the oral placebo group, melatonin decreased the concentration of fibrinogen (Fbg) (P = 0.04) and free fatty acids (FFA) (P = 0.04) in smokers, along with the decreased expression of ICAM-1, VCAM-1 and ET-1 (P = 0.004, P = 0.001, P < 0.0001, respectively). Melatonin 38-47 fibrinogen beta chain Homo sapiens 91-94 26721373-9 2016 Apart from an increase in testosterone levels, if administered to atorvastatin-treated subjects with LOH, testosterone reduced plasma levels of LDL cholesterol, uric acid, hsCRP, homocysteine, and fibrinogen, as well as improved insulin sensitivity. Atorvastatin 66-78 fibrinogen beta chain Homo sapiens 197-207 26612741-4 2016 Mammalian ferritin binds both heme and iron, and binding occurs through two mechanisms: direct binding with ferritin to H-kininogen and anti-ferritin autoantibody, and indirect heme-mediated binding of fibrinogen and apolipoprotein B to ferritin. Heme 177-181 fibrinogen beta chain Homo sapiens 202-212 26721356-8 2016 Testosterone-metformin combination therapy reduced also circulating levels of uric acid, homocysteine and fibrinogen. testosterone-metformin 0-22 fibrinogen beta chain Homo sapiens 106-116 26721373-9 2016 Apart from an increase in testosterone levels, if administered to atorvastatin-treated subjects with LOH, testosterone reduced plasma levels of LDL cholesterol, uric acid, hsCRP, homocysteine, and fibrinogen, as well as improved insulin sensitivity. Testosterone 106-118 fibrinogen beta chain Homo sapiens 197-207 26913389-7 2016 FIB levels decreased slower after treatment of PEG-ASP (9.49 vs 6.90) (P = 0.000) than that after treatment of L-ASP. peg-asp 47-54 fibrinogen beta chain Homo sapiens 0-3 26729371-8 2016 Ionised calcium concentrations and its interaction term with platelet count were both significantly associated with the MA on the TEG (slope of the regression line 1 1 per 0 1 mmol L(-1) increment, 95%CI 0 3 to 1 9, P = 0 011), after adjusting for fibrinogen concentrations, platelet counts, INR and aPTT. Calcium 8-15 fibrinogen beta chain Homo sapiens 248-258 26913389-7 2016 FIB levels decreased slower after treatment of PEG-ASP (9.49 vs 6.90) (P = 0.000) than that after treatment of L-ASP. Aspartic Acid 111-116 fibrinogen beta chain Homo sapiens 0-3 26913389-8 2016 When L-ASP used at interval, FIB level decreased slower than that of continuous use. Aspartic Acid 5-10 fibrinogen beta chain Homo sapiens 29-32 26742890-3 2016 Herein we develop a variant of a CoPhMoRe screening procedure of single-walled carbon nanotubes (SWCNT) and use it against a panel of human blood proteins, revealing a specific corona phase that recognizes fibrinogen with high selectivity. Carbon 79-85 fibrinogen beta chain Homo sapiens 206-216 26751065-8 2016 In CKD 3-5, TMAO levels were associated with IL-6 (Rho = 0.42; p<0.0001), fibrinogen (Rho = 0.43; p<0.0001) and hsCRP (Rho = 0.17; p = 0.022). trimethyloxamine 12-16 fibrinogen beta chain Homo sapiens 77-87 26684255-0 2016 Serum bilirubin levels are inversely associated with PAI-1 and fibrinogen in Korean subjects. Bilirubin 6-15 fibrinogen beta chain Homo sapiens 63-73 26734075-10 2016 Only rosiglitazone decreased Homa beta, PAI-1 activity, CRP, fibrinogen, TGFbeta, FFA and triglyceride levels. Rosiglitazone 5-18 fibrinogen beta chain Homo sapiens 61-71 26690693-9 2016 Furthermore, ESR and fibrinogen were significantly positively correlated with HbA1c and negatively correlated with HDL cholesterol, however not correlated with fasting glucose. Cholesterol 119-130 fibrinogen beta chain Homo sapiens 21-31 26684255-3 2016 This study investigated the association of serum bilirubin with fibrinogen and plasminogen activator inhibitor-1 (PAI-1), respectively. Bilirubin 49-58 fibrinogen beta chain Homo sapiens 64-74 26684255-7 2016 Correlation analysis revealed linear relationships of fibrinogen with TB and direct bilirubin (DB), whereas PAI-1 was correlated with DB. Bilirubin 70-72 fibrinogen beta chain Homo sapiens 54-64 26684255-7 2016 Correlation analysis revealed linear relationships of fibrinogen with TB and direct bilirubin (DB), whereas PAI-1 was correlated with DB. Bilirubin 84-93 fibrinogen beta chain Homo sapiens 54-64 26684255-8 2016 After adjustment for confounding factors, bilirubin levels were inversely associated with fibrinogen and PAI-1 levels, respectively. Bilirubin 42-51 fibrinogen beta chain Homo sapiens 90-100 26684255-9 2016 Multivariate regression models showed a negative linear relationship between all types of bilirubin and fibrinogen, whereas there was a significant linear relationship between PAI-1 and DB. Bilirubin 90-99 fibrinogen beta chain Homo sapiens 104-114 26684255-10 2016 CONCLUSIONS: High bilirubin concentrations were independently associated with low levels of fibrinogen and PAI-1, respectively. Bilirubin 18-27 fibrinogen beta chain Homo sapiens 92-102 26652157-3 2016 GPIIb/IIIa functions as a receptor for fibrinogen and several adhesion proteins sharing an arginine-glycine-aspartic acid (RGD) sequence. arginyl-glycyl-aspartic acid 91-121 fibrinogen beta chain Homo sapiens 39-49 26888150-9 2016 CONCLUSIONS: Preoperatively high fibrinogen and low plasminogen values in patients with CTEPH are associated with poor long-term postoperative outcome. cteph 88-93 fibrinogen beta chain Homo sapiens 33-43 26861101-6 2016 We administered tranexamic acid early in the pregnancy, and the subchorionic hematoma diminished in size in accordance with the increase of her fibrinogen level. Tranexamic Acid 16-31 fibrinogen beta chain Homo sapiens 144-154 26657419-6 2016 When the analysis was stratified according to the type of fibrate administered, there were significant Fib-lowering effects with both bezafibrate (n=8 treatment arms; WMD: -23.7mg/dL, 95% CI: -41.8, -5.7, p=0.01) and fenofibrate (n=15 treatment arms; WMD: -43.7mg/dL, 95% CI: -61.3, -26.2, p<0.001). Bezafibrate 134-145 fibrinogen beta chain Homo sapiens 103-106 27713770-7 2016 Generally, Vit D levels were associated indirectly with leukocytes/ neutrophils number or with ESR, CRP, and Fibrinogen levels. Vitamin D 11-16 fibrinogen beta chain Homo sapiens 109-119 25395167-0 2016 Fibrinogen enhances the inflammatory response of alveolar macrophages to TiO2, SiO2 and carbon nanomaterials. titanium dioxide 73-77 fibrinogen beta chain Homo sapiens 0-10 25395167-0 2016 Fibrinogen enhances the inflammatory response of alveolar macrophages to TiO2, SiO2 and carbon nanomaterials. Silicon Dioxide 79-83 fibrinogen beta chain Homo sapiens 0-10 25395167-0 2016 Fibrinogen enhances the inflammatory response of alveolar macrophages to TiO2, SiO2 and carbon nanomaterials. Carbon 88-94 fibrinogen beta chain Homo sapiens 0-10 25395167-6 2016 A set of integrated techniques (UV-vis spectroscopy, dynamic light scattering and sodium dodecyl sulphate-polyacrylamide gel electrophoresis) have been used to study the strength and the kinetics of interaction of FG with the NMs. Sodium Dodecyl Sulfate 82-105 fibrinogen beta chain Homo sapiens 214-216 25395167-6 2016 A set of integrated techniques (UV-vis spectroscopy, dynamic light scattering and sodium dodecyl sulphate-polyacrylamide gel electrophoresis) have been used to study the strength and the kinetics of interaction of FG with the NMs. polyacrylamide gels 106-124 fibrinogen beta chain Homo sapiens 214-216 25395167-8 2016 We found that FG significantly enhances the cytotoxicity (lactate dehydrogenase leakage) and the inflammatory response (increase in nitric oxide (NO) concentration and NO synthase activation) induced by SiO2, carbon and TiO2 NMs on alveolar macrophages. Nitric Oxide 132-144 fibrinogen beta chain Homo sapiens 14-16 25395167-8 2016 We found that FG significantly enhances the cytotoxicity (lactate dehydrogenase leakage) and the inflammatory response (increase in nitric oxide (NO) concentration and NO synthase activation) induced by SiO2, carbon and TiO2 NMs on alveolar macrophages. Silicon Dioxide 203-207 fibrinogen beta chain Homo sapiens 14-16 25395167-8 2016 We found that FG significantly enhances the cytotoxicity (lactate dehydrogenase leakage) and the inflammatory response (increase in nitric oxide (NO) concentration and NO synthase activation) induced by SiO2, carbon and TiO2 NMs on alveolar macrophages. Carbon 209-215 fibrinogen beta chain Homo sapiens 14-16 25395167-8 2016 We found that FG significantly enhances the cytotoxicity (lactate dehydrogenase leakage) and the inflammatory response (increase in nitric oxide (NO) concentration and NO synthase activation) induced by SiO2, carbon and TiO2 NMs on alveolar macrophages. titanium dioxide 220-224 fibrinogen beta chain Homo sapiens 14-16 25395167-10 2016 In the case of carbon NMs, the activation of fibrinolysis, likely related to the exposure of cryptic sites of FG, was also observed after 24 h. These findings underline the critical role played by FG in the toxic response to NMs. Carbon 15-21 fibrinogen beta chain Homo sapiens 197-199 25901600-6 2016 Platelet function was assessed by CD63, P-selectin and bound fibrinogen in response to arachidonic acid, adenosine diphosphate (ADP), collagen-related peptide, ristocetin and thrombin receptor-activation peptide-6. Arachidonic Acid 87-103 fibrinogen beta chain Homo sapiens 61-71 25901600-6 2016 Platelet function was assessed by CD63, P-selectin and bound fibrinogen in response to arachidonic acid, adenosine diphosphate (ADP), collagen-related peptide, ristocetin and thrombin receptor-activation peptide-6. Adenosine Diphosphate 105-126 fibrinogen beta chain Homo sapiens 61-71 26083984-0 2015 Novel fibrinogen mutations (Aalpha17Gly Cys and Aalpha381Ser Phe) occurring with a 312Thr Ala polymorphism: allelic phase assigned by direct mass measurement. Cysteine 40-43 fibrinogen beta chain Homo sapiens 6-16 26162328-0 2015 A quantitative binding study of fibrinogen and human serum albumin to metal oxide nanoparticles by surface plasmon resonance. metal oxide 70-81 fibrinogen beta chain Homo sapiens 32-42 26162328-2 2015 In this study, new approaches were applied to measure quantitatively the kinetics and affinities of fibrinogen and human serum albumin (HSA) for TiO2, CeO2, Al2O3 and ZnO NPs immobilized on a sensor chip. titanium dioxide 145-149 fibrinogen beta chain Homo sapiens 100-110 26162328-2 2015 In this study, new approaches were applied to measure quantitatively the kinetics and affinities of fibrinogen and human serum albumin (HSA) for TiO2, CeO2, Al2O3 and ZnO NPs immobilized on a sensor chip. ceric oxide 151-155 fibrinogen beta chain Homo sapiens 100-110 26162328-2 2015 In this study, new approaches were applied to measure quantitatively the kinetics and affinities of fibrinogen and human serum albumin (HSA) for TiO2, CeO2, Al2O3 and ZnO NPs immobilized on a sensor chip. Aluminum Oxide 157-162 fibrinogen beta chain Homo sapiens 100-110 26162328-2 2015 In this study, new approaches were applied to measure quantitatively the kinetics and affinities of fibrinogen and human serum albumin (HSA) for TiO2, CeO2, Al2O3 and ZnO NPs immobilized on a sensor chip. Zinc Oxide 167-170 fibrinogen beta chain Homo sapiens 100-110 26162328-3 2015 Real-time surface plasmon resonance (SPR) measurements showed that fibrinogen interacted with TiO2 and CeO2 NPs with high affinity (135 and 40 pM, respectively) and to Al2O3 NPs with moderate affinity (15 nM). titanium dioxide 94-98 fibrinogen beta chain Homo sapiens 67-77 26162328-3 2015 Real-time surface plasmon resonance (SPR) measurements showed that fibrinogen interacted with TiO2 and CeO2 NPs with high affinity (135 and 40 pM, respectively) and to Al2O3 NPs with moderate affinity (15 nM). Aluminum Oxide 168-173 fibrinogen beta chain Homo sapiens 67-77 26162328-6 2015 TiO2 and CeO2 NPs had fast association rate constants with fibrinogen (1x10(6) M(-1) s(-1)) and Al2O3 NPs had a slower association rate constant (1x10(4) M(-1) s(-1)). titanium dioxide 0-4 fibrinogen beta chain Homo sapiens 59-69 26569042-0 2015 Molecular Dynamics Simulations of the Initial Adsorption Stages of Fibrinogen on Mica and Graphite Surfaces. Graphite 90-98 fibrinogen beta chain Homo sapiens 67-77 26569042-3 2015 Here we present the first fully atomistic simulations of the initial stages of the adsorption process of fibrinogen on mica and graphite surfaces. Graphite 128-136 fibrinogen beta chain Homo sapiens 105-115 26604093-10 2015 Patients with high baseline fibrinogen had a significantly shorter DFS (pooled HR = 1.52) and CSS (pooled HR = 2.50). thiocysteine 94-97 fibrinogen beta chain Homo sapiens 28-38 26083984-0 2015 Novel fibrinogen mutations (Aalpha17Gly Cys and Aalpha381Ser Phe) occurring with a 312Thr Ala polymorphism: allelic phase assigned by direct mass measurement. Phenylalanine 61-64 fibrinogen beta chain Homo sapiens 6-16 26083984-0 2015 Novel fibrinogen mutations (Aalpha17Gly Cys and Aalpha381Ser Phe) occurring with a 312Thr Ala polymorphism: allelic phase assigned by direct mass measurement. Alanine 90-93 fibrinogen beta chain Homo sapiens 6-16 25527412-1 2015 Higher levels of fibrinogen or cholesterol were associated with improved hearing recovery in SSHL patients after treatment with HELP-apheresis (Heparin-induced extracorporeal LDL precipitation apheresis). Heparin 144-151 fibrinogen beta chain Homo sapiens 17-27 26209759-0 2015 Mechanisms of fibrinogen adsorption at the silica substrate determined by QCM-D measurements. Silicon Dioxide 43-49 fibrinogen beta chain Homo sapiens 14-24 26554451-0 2015 Mechanical fibrinogen-depletion supports heparin-free mesenchymal stem cell propagation in human platelet lysate. Heparin 41-48 fibrinogen beta chain Homo sapiens 11-21 26603798-4 2015 The thromboelastographic functional fibrinogen assay showed that the fibrinogen component of clot strength was significantly impaired with haemodilution with HES 130/0.4 compared with haemodilution with NS (whole blood [14.4 +- 4.6 mm] versus 40% HES dilution [3.7 +- 1.9], [P=0.001]; versus 40% NS dilution [10.4 +- 4.6], [P=0.129]). Hydroxyethyl Starch Derivatives 158-161 fibrinogen beta chain Homo sapiens 69-79 26603798-4 2015 The thromboelastographic functional fibrinogen assay showed that the fibrinogen component of clot strength was significantly impaired with haemodilution with HES 130/0.4 compared with haemodilution with NS (whole blood [14.4 +- 4.6 mm] versus 40% HES dilution [3.7 +- 1.9], [P=0.001]; versus 40% NS dilution [10.4 +- 4.6], [P=0.129]). Hydroxyethyl Starch Derivatives 247-250 fibrinogen beta chain Homo sapiens 69-79 26603798-5 2015 These findings suggest that there is little difference between HES or NS in relation to coagulation or platelet function during minor or moderate haemodilution, but at high levels of haemodilution with HES, fibrinogen activity is more impaired compared with NS. Hydroxyethyl Starch Derivatives 202-205 fibrinogen beta chain Homo sapiens 207-217 26540111-7 2015 Multivariate analysis adjusted for fibrinogen showed that Ks was predicted by eosinophil count, peak thrombin generation, factor VIII, and soluble CD40 ligand, whereas eosinophil count, peak thrombin generation and antiplasmin predicted t50%. Potassium 58-60 fibrinogen beta chain Homo sapiens 35-45 25982359-0 2015 Coexisting congenital dysfibrinogenemia with a novel mutation in fibrinogen gamma chain (gamma322 Phe Ile, Fibrinogen Beijing) and haemophilia B in a family. Phenylalanine 98-101 fibrinogen beta chain Homo sapiens 25-35 26209759-1 2015 Adsorption kinetics of fibrinogen at a silica substrate was thoroughly studied in situ using the QCM-D method. Silicon Dioxide 39-45 fibrinogen beta chain Homo sapiens 23-33 26209759-5 2015 In this way, the hydration functions and water factors of fibrinogen monolayers were quantitatively evaluated for various pHs. Water 41-46 fibrinogen beta chain Homo sapiens 58-68 26393413-0 2015 Structural Reorganization and Fibrinogen Adsorption Behaviors on the Polyrotaxane Surfaces Investigated by Sum Frequency Generation Spectroscopy. polyrotaxane 69-81 fibrinogen beta chain Homo sapiens 30-40 29632828-5 2015 Fibrinogen, precursor of fibrin, was adsorbed (test protein) on three different polymeric surfaces: silicone, poly(acrylic acid)-coated silicone and poly(allylamine)-coated silicone. Silicones 100-108 fibrinogen beta chain Homo sapiens 0-10 29632828-5 2015 Fibrinogen, precursor of fibrin, was adsorbed (test protein) on three different polymeric surfaces: silicone, poly(acrylic acid)-coated silicone and poly(allylamine)-coated silicone. carbopol 940 110-128 fibrinogen beta chain Homo sapiens 0-10 29632828-5 2015 Fibrinogen, precursor of fibrin, was adsorbed (test protein) on three different polymeric surfaces: silicone, poly(acrylic acid)-coated silicone and poly(allylamine)-coated silicone. Silicones 136-144 fibrinogen beta chain Homo sapiens 0-10 29632828-5 2015 Fibrinogen, precursor of fibrin, was adsorbed (test protein) on three different polymeric surfaces: silicone, poly(acrylic acid)-coated silicone and poly(allylamine)-coated silicone. polyallylamine 149-165 fibrinogen beta chain Homo sapiens 0-10 29632828-5 2015 Fibrinogen, precursor of fibrin, was adsorbed (test protein) on three different polymeric surfaces: silicone, poly(acrylic acid)-coated silicone and poly(allylamine)-coated silicone. Silicones 136-144 fibrinogen beta chain Homo sapiens 0-10 29632828-8 2015 The novel immuno-based assay showed significantly stronger binding of fibrinogen to both poly(acrylic acid) and poly(allylamine) coated silicone. carbopol 940 89-107 fibrinogen beta chain Homo sapiens 70-80 29632828-8 2015 The novel immuno-based assay showed significantly stronger binding of fibrinogen to both poly(acrylic acid) and poly(allylamine) coated silicone. polyallylamine 112-128 fibrinogen beta chain Homo sapiens 70-80 29632828-8 2015 The novel immuno-based assay showed significantly stronger binding of fibrinogen to both poly(acrylic acid) and poly(allylamine) coated silicone. Silicones 136-144 fibrinogen beta chain Homo sapiens 70-80 26393413-2 2015 To provide a general design principle for biomedical materials, we examined the surface reorganization behaviors and adsorption conformations of fibrinogen on the polyrotaxane surfaces with comparison to several random copolymers by sum frequency generation (SFG) vibrational spectroscopy. polyrotaxane 163-175 fibrinogen beta chain Homo sapiens 145-155 26393413-5 2015 The orientation analysis revealed that the orientation of the fibrinogen adsorbed on the OMe-PRX-PMB surface is close to a single distribution, which is different from the adsorption behaviors of fibrinogen on other polyrotaxane or random copolymer surfaces. prx-pmb 93-100 fibrinogen beta chain Homo sapiens 62-72 26393413-5 2015 The orientation analysis revealed that the orientation of the fibrinogen adsorbed on the OMe-PRX-PMB surface is close to a single distribution, which is different from the adsorption behaviors of fibrinogen on other polyrotaxane or random copolymer surfaces. prx-pmb 93-100 fibrinogen beta chain Homo sapiens 196-206 26393413-5 2015 The orientation analysis revealed that the orientation of the fibrinogen adsorbed on the OMe-PRX-PMB surface is close to a single distribution, which is different from the adsorption behaviors of fibrinogen on other polyrotaxane or random copolymer surfaces. polyrotaxane 216-228 fibrinogen beta chain Homo sapiens 62-72 26393413-5 2015 The orientation analysis revealed that the orientation of the fibrinogen adsorbed on the OMe-PRX-PMB surface is close to a single distribution, which is different from the adsorption behaviors of fibrinogen on other polyrotaxane or random copolymer surfaces. copolymer 239-248 fibrinogen beta chain Homo sapiens 62-72 26238934-5 2015 The results showed that pravastatin dose-dependently inhibited fibrinogen- and FDP-stimulated expression of IL-6, TNF-alpha and iNOS in VSMCs at the mRNA and protein level. Pravastatin 24-35 fibrinogen beta chain Homo sapiens 63-73 26346586-8 2015 RESULTS: Univariable analysis revealed a significant association between an elevated plasma fibrinogen level and DSS (hazard ratio (HR) 1.70, 95% CI 1.07-2.76, p = 0.026) that remained significant in multivariable analysis (HR 1.71, 95% CI 1.02-2.85; p = 0.042). dss 113-116 fibrinogen beta chain Homo sapiens 92-102 26346586-10 2015 In patients with ER/PR+, HER2- tumors, plasma fibrinogen was associated with DSS in univariable (HR 2.65, 95% CI 1.15-6.14, p = 0.023) and multivariable analysis (HR 3.63, 95% CI 1.37-9.64, p = 0.010). dss 77-80 fibrinogen beta chain Homo sapiens 46-56 26346586-11 2015 Furthermore, in those patients, the estimated c-index of the multivariable model for DSS was 0.755 without fibrinogen and 0.785 when fibrinogen was added. dss 85-88 fibrinogen beta chain Homo sapiens 107-117 26346586-11 2015 Furthermore, in those patients, the estimated c-index of the multivariable model for DSS was 0.755 without fibrinogen and 0.785 when fibrinogen was added. dss 85-88 fibrinogen beta chain Homo sapiens 133-143 24888232-0 2015 Enhanced bone healing by improved fibrin-clot formation via fibrinogen adsorption on biphasic calcium phosphate granules. calcium phosphate 94-111 fibrinogen beta chain Homo sapiens 60-70 24888232-2 2015 This study aimed at improving the fibrin-clotting rate by coating the surface of biphasic calcium phosphate (BCP) granules with fibrinogen (FNG). calcium phosphate 90-107 fibrinogen beta chain Homo sapiens 128-138 24888232-2 2015 This study aimed at improving the fibrin-clotting rate by coating the surface of biphasic calcium phosphate (BCP) granules with fibrinogen (FNG). calcium phosphate 90-107 fibrinogen beta chain Homo sapiens 140-143 24888232-2 2015 This study aimed at improving the fibrin-clotting rate by coating the surface of biphasic calcium phosphate (BCP) granules with fibrinogen (FNG). hydroxyapatite-beta tricalcium phosphate 109-112 fibrinogen beta chain Homo sapiens 128-138 24888232-2 2015 This study aimed at improving the fibrin-clotting rate by coating the surface of biphasic calcium phosphate (BCP) granules with fibrinogen (FNG). hydroxyapatite-beta tricalcium phosphate 109-112 fibrinogen beta chain Homo sapiens 140-143 24888232-3 2015 METHODS AND MATERIALS: FNG was coated on the BCP surface using an adsorption and freeze-drying method. hydroxyapatite-beta tricalcium phosphate 45-48 fibrinogen beta chain Homo sapiens 23-26 24888232-4 2015 The surface morphology of FNG-adsorbed BCP (FNG-BCP) was characterized using scanning electron microscopy (SEM), and the stability of the adsorbed FNG evaluated by gel electrophoresis and circular dichroism (CD) analysis. hydroxyapatite-beta tricalcium phosphate 39-42 fibrinogen beta chain Homo sapiens 26-29 24888232-4 2015 The surface morphology of FNG-adsorbed BCP (FNG-BCP) was characterized using scanning electron microscopy (SEM), and the stability of the adsorbed FNG evaluated by gel electrophoresis and circular dichroism (CD) analysis. hydroxyapatite-beta tricalcium phosphate 39-42 fibrinogen beta chain Homo sapiens 44-47 24888232-4 2015 The surface morphology of FNG-adsorbed BCP (FNG-BCP) was characterized using scanning electron microscopy (SEM), and the stability of the adsorbed FNG evaluated by gel electrophoresis and circular dichroism (CD) analysis. hydroxyapatite-beta tricalcium phosphate 39-42 fibrinogen beta chain Homo sapiens 44-47 24888232-6 2015 RESULTS: SEM studies showed numerous irregularly distributed FNG fractions adsorbed onto the surface of BCP granules. hydroxyapatite-beta tricalcium phosphate 104-107 fibrinogen beta chain Homo sapiens 61-64 26581464-4 2015 Two sections of each (H & E) case were taken, one was stained with hematoxylin and eosin and another with fluorescein isothiocynate conjugate (FITC) polyclonal rabbit antibody against fibrinogen. Fluorescein-5-isothiocyanate 147-151 fibrinogen beta chain Homo sapiens 188-198 26238934-0 2015 Pravastatin inhibits fibrinogen- and FDP-induced inflammatory response via reducing the production of IL-6, TNF-alpha and iNOS in vascular smooth muscle cells. Pravastatin 0-11 fibrinogen beta chain Homo sapiens 21-31 26238934-4 2015 In the present study, the effects of pravastatin on fibrinogen- and FDP-induced expression of IL-6, TNF-alpha and iNOS were observed in VSMCs. Pravastatin 37-48 fibrinogen beta chain Homo sapiens 52-62 26031507-6 2015 Fenofibrate administered alone increased HDL cholesterol, reduced triglycerides, decreased insulin resistance, reduced circulating levels of uric acid, hsCRP, and fibrinogen, as well as increased plasma levels of homocysteine. Fenofibrate 0-11 fibrinogen beta chain Homo sapiens 163-173 26031507-7 2015 The strongest effect on testosterone, HOMA1-IR, uric acid, hsCRP, and fibrinogen was observed if fenofibrate was administered together with testosterone. Fenofibrate 97-108 fibrinogen beta chain Homo sapiens 70-80 26031507-7 2015 The strongest effect on testosterone, HOMA1-IR, uric acid, hsCRP, and fibrinogen was observed if fenofibrate was administered together with testosterone. Testosterone 140-152 fibrinogen beta chain Homo sapiens 70-80 26319423-8 2015 CONCLUSION: Intervention with B12 and folic acid is effective in reducing Hcy, PAI 1, fibrinogen levels and increasing NO levels at 1yr as compared to control arm and reducing the incidence of thrombosis at 2years of stay at HAA. Folic Acid 38-48 fibrinogen beta chain Homo sapiens 86-96 26732911-4 2015 Furthermore, cleavage pattern on fibrinogen was evaluated using SDS-PAGE and defibrinogenant activity on white mice (18-22 g). Sodium Dodecyl Sulfate 64-67 fibrinogen beta chain Homo sapiens 33-43 26269934-8 2015 Overall, concentrations of the fluorescent carbon dots at <=0.1 mg/mL had few adverse effects on the blood components, but at higher doses, the carbon dots impair the structure and function of the blood components, causing morphological disruptions and lysis of red blood cells, interference in the local microenvironments of fibrinogen, activation of the complement system, and disturbances in the plasma and whole blood coagulation function in vitro. Carbon 43-49 fibrinogen beta chain Homo sapiens 329-339 26269934-8 2015 Overall, concentrations of the fluorescent carbon dots at <=0.1 mg/mL had few adverse effects on the blood components, but at higher doses, the carbon dots impair the structure and function of the blood components, causing morphological disruptions and lysis of red blood cells, interference in the local microenvironments of fibrinogen, activation of the complement system, and disturbances in the plasma and whole blood coagulation function in vitro. Carbon 147-153 fibrinogen beta chain Homo sapiens 329-339 25719321-11 2015 CONCLUSIONS: While the influence observed for glycine may be due to fibrinogen precipitation, the mechanism of mannitol appears to be more complex as platelet function as well as fibrin-based clot formation are influenced. Glycine 46-53 fibrinogen beta chain Homo sapiens 68-78 26083991-12 2015 Although early FgDPs have a pronounced effect on blood clot formation in vitro and therefore may induce or enhance in vivo coagulopathy, the drop of fibrinogen concentration seen after CABG surgery (using tranexamic acid) is primarily caused by hemodilution. Tranexamic Acid 205-220 fibrinogen beta chain Homo sapiens 149-159 26331319-10 2015 Vitamin D levels were negatively correlated with IMA and fibrinogen levels (r = -0.500, p < 0.001 and r = -0.391, p = 0.002, respectively), although positively correlated with TAS levels (r = 0.430, p < 0.001). Vitamin D 0-9 fibrinogen beta chain Homo sapiens 57-67 26366073-0 2015 Biocompatible and biodegradable fibrinogen microspheres for tumor-targeted doxorubicin delivery. Doxorubicin 75-86 fibrinogen beta chain Homo sapiens 32-42 26366073-3 2015 Doxorubicin (DOX), a chemotherapeutic agent, was covalently conjugated to Fbg, and the microspheres were prepared. Doxorubicin 0-11 fibrinogen beta chain Homo sapiens 74-77 26366073-3 2015 Doxorubicin (DOX), a chemotherapeutic agent, was covalently conjugated to Fbg, and the microspheres were prepared. Doxorubicin 13-16 fibrinogen beta chain Homo sapiens 74-77 26366073-4 2015 Acid-labile and non-cleavable linkers were used for the conjugation of DOX to Fbg, resulting in an acid-triggered drug release under a mild acidic condition and a slow-controlled drug release, respectively. Doxorubicin 71-74 fibrinogen beta chain Homo sapiens 78-81 26366073-7 2015 Therefore, DOX-linker-Fbg microspheres could be a suitable drug carrier for safer and effective drug delivery. Doxorubicin 11-14 fibrinogen beta chain Homo sapiens 22-25 26347331-4 2015 On the coated HP layer, immunoglobulin G was then immobilized for specific capturing of Fbg. Hematoporphyrins 14-16 fibrinogen beta chain Homo sapiens 88-91 26241902-8 2015 CD34+ cell number appeared to be associated with vitamin D levels, and negatively correlated to fibrinogen and early atherosclerosis markers (PWV and cIMT); vitamin D levels appear also to be inversely associated to fibrinogen. Vitamin D 157-166 fibrinogen beta chain Homo sapiens 216-226 26241902-9 2015 CONCLUSIONS: RA patients with moderate disease activity presented with low vitamin D levels, low CD34+ cell count, increased PWV and cIMT; we found that vitamin D deficiency is associated to CD34+ cell reduction in peripheral blood, and with fibrinogen levels. Vitamin D 153-162 fibrinogen beta chain Homo sapiens 242-252 26396488-6 2015 The plasma fibrinogen levels explained 17% of the TBARS variance, with a significant correlation between these two markers (p=0.011). Thiobarbituric Acid Reactive Substances 50-55 fibrinogen beta chain Homo sapiens 11-21 25986992-2 2015 Of interest, SCD patients can become iron overloaded after transfusion, and iron can enhance fibrinogen as a substrate for thrombin, resulting in thrombi that commence coagulation quickly and form rapidly. Iron 76-80 fibrinogen beta chain Homo sapiens 93-103 25860295-1 2015 Both human and horse fibrinogen are heme-binding proteins, and horse fibrinogen also exhibits heme-mediated ferritin binding. Heme 36-40 fibrinogen beta chain Homo sapiens 21-31 25860295-2 2015 This study found that bovine and human fibrinogen are heme-mediated ferritin-binding proteins and demonstrated direct binding of bovine ferritin to protoporphyrin (PPIX) and its derivatives or to Zn ions. protoporphyrin IX 148-162 fibrinogen beta chain Homo sapiens 39-49 25860295-2 2015 This study found that bovine and human fibrinogen are heme-mediated ferritin-binding proteins and demonstrated direct binding of bovine ferritin to protoporphyrin (PPIX) and its derivatives or to Zn ions. protoporphyrin IX 164-168 fibrinogen beta chain Homo sapiens 39-49 25860295-2 2015 This study found that bovine and human fibrinogen are heme-mediated ferritin-binding proteins and demonstrated direct binding of bovine ferritin to protoporphyrin (PPIX) and its derivatives or to Zn ions. Zinc 196-198 fibrinogen beta chain Homo sapiens 39-49 25860295-3 2015 Binding of bovine and human fibrinogen to bovine spleen ferritin coated on microtiter plate wells was detected using an anti-human fibrinogen antibody, and this binding was inhibited in a dose-dependent manner by hemin (iron-PPIX) and also inhibited by Zn-PPIX. Hemin 213-218 fibrinogen beta chain Homo sapiens 28-38 25860295-3 2015 Binding of bovine and human fibrinogen to bovine spleen ferritin coated on microtiter plate wells was detected using an anti-human fibrinogen antibody, and this binding was inhibited in a dose-dependent manner by hemin (iron-PPIX) and also inhibited by Zn-PPIX. Hemin 213-218 fibrinogen beta chain Homo sapiens 131-141 25860295-3 2015 Binding of bovine and human fibrinogen to bovine spleen ferritin coated on microtiter plate wells was detected using an anti-human fibrinogen antibody, and this binding was inhibited in a dose-dependent manner by hemin (iron-PPIX) and also inhibited by Zn-PPIX. iron-ppix 220-229 fibrinogen beta chain Homo sapiens 28-38 25860295-3 2015 Binding of bovine and human fibrinogen to bovine spleen ferritin coated on microtiter plate wells was detected using an anti-human fibrinogen antibody, and this binding was inhibited in a dose-dependent manner by hemin (iron-PPIX) and also inhibited by Zn-PPIX. zinc protoporphyrin 253-260 fibrinogen beta chain Homo sapiens 28-38 25860295-4 2015 PPIX showed less of an inhibitory effect on the binding of bovine and human fibrinogen to bovine ferritin. protoporphyrin IX 0-4 fibrinogen beta chain Homo sapiens 76-86 25860295-6 2015 Bovine fibrinogen immobilized on CNBr-activated Sepharose 4B beads showed affinity for hemin, Sn-PPIX, Zn-PPIX, and iron-free PPIX in the order Sn-PPIX < iron-free PPIX < hemin < Zn-PPIX. Sepharose 48-60 fibrinogen beta chain Homo sapiens 7-17 25860295-6 2015 Bovine fibrinogen immobilized on CNBr-activated Sepharose 4B beads showed affinity for hemin, Sn-PPIX, Zn-PPIX, and iron-free PPIX in the order Sn-PPIX < iron-free PPIX < hemin < Zn-PPIX. Hemin 87-92 fibrinogen beta chain Homo sapiens 7-17 26050259-0 2015 Carbohydrate-binding activities of coagulation factors fibrinogen and fibrin. Carbohydrates 0-12 fibrinogen beta chain Homo sapiens 55-65 26050259-3 2015 Here we demonstrate that fibrinogen and fibrin have carbohydrate-specific binding activities that inhibit fibrin clot formation. Carbohydrates 52-64 fibrinogen beta chain Homo sapiens 25-35 26050259-4 2015 A solid-phase binding study using sugar-biotinyl polymer probes revealed that fibrinogen has the highest affinity to mannose (Man) in both the presence and absence of 5 mM Ca(2+). Sugars 34-39 fibrinogen beta chain Homo sapiens 78-88 26050259-4 2015 A solid-phase binding study using sugar-biotinyl polymer probes revealed that fibrinogen has the highest affinity to mannose (Man) in both the presence and absence of 5 mM Ca(2+). biotinyl polymer 40-56 fibrinogen beta chain Homo sapiens 78-88 26050259-4 2015 A solid-phase binding study using sugar-biotinyl polymer probes revealed that fibrinogen has the highest affinity to mannose (Man) in both the presence and absence of 5 mM Ca(2+). Mannose 117-124 fibrinogen beta chain Homo sapiens 78-88 26050259-5 2015 Fibrin, which is proteolytically produced from fibrinogen by thrombin, binds to the same sugar residues as fibrinogen in the presence of 5 mM Ca(2+), while it markedly binds to N-acetylneuraminic acid in the absence of Ca(2+). Sugars 89-94 fibrinogen beta chain Homo sapiens 47-57 26050259-5 2015 Fibrin, which is proteolytically produced from fibrinogen by thrombin, binds to the same sugar residues as fibrinogen in the presence of 5 mM Ca(2+), while it markedly binds to N-acetylneuraminic acid in the absence of Ca(2+). N-Acetylneuraminic Acid 177-200 fibrinogen beta chain Homo sapiens 47-57 25860295-6 2015 Bovine fibrinogen immobilized on CNBr-activated Sepharose 4B beads showed affinity for hemin, Sn-PPIX, Zn-PPIX, and iron-free PPIX in the order Sn-PPIX < iron-free PPIX < hemin < Zn-PPIX. tin protoporphyrin IX 94-101 fibrinogen beta chain Homo sapiens 7-17 25860295-6 2015 Bovine fibrinogen immobilized on CNBr-activated Sepharose 4B beads showed affinity for hemin, Sn-PPIX, Zn-PPIX, and iron-free PPIX in the order Sn-PPIX < iron-free PPIX < hemin < Zn-PPIX. zinc protoporphyrin 103-110 fibrinogen beta chain Homo sapiens 7-17 25860295-6 2015 Bovine fibrinogen immobilized on CNBr-activated Sepharose 4B beads showed affinity for hemin, Sn-PPIX, Zn-PPIX, and iron-free PPIX in the order Sn-PPIX < iron-free PPIX < hemin < Zn-PPIX. Iron 116-120 fibrinogen beta chain Homo sapiens 7-17 25860295-6 2015 Bovine fibrinogen immobilized on CNBr-activated Sepharose 4B beads showed affinity for hemin, Sn-PPIX, Zn-PPIX, and iron-free PPIX in the order Sn-PPIX < iron-free PPIX < hemin < Zn-PPIX. protoporphyrin IX 97-101 fibrinogen beta chain Homo sapiens 7-17 25860295-6 2015 Bovine fibrinogen immobilized on CNBr-activated Sepharose 4B beads showed affinity for hemin, Sn-PPIX, Zn-PPIX, and iron-free PPIX in the order Sn-PPIX < iron-free PPIX < hemin < Zn-PPIX. tin protoporphyrin IX 144-151 fibrinogen beta chain Homo sapiens 7-17 25860295-6 2015 Bovine fibrinogen immobilized on CNBr-activated Sepharose 4B beads showed affinity for hemin, Sn-PPIX, Zn-PPIX, and iron-free PPIX in the order Sn-PPIX < iron-free PPIX < hemin < Zn-PPIX. Iron 157-161 fibrinogen beta chain Homo sapiens 7-17 25860295-6 2015 Bovine fibrinogen immobilized on CNBr-activated Sepharose 4B beads showed affinity for hemin, Sn-PPIX, Zn-PPIX, and iron-free PPIX in the order Sn-PPIX < iron-free PPIX < hemin < Zn-PPIX. protoporphyrin IX 106-110 fibrinogen beta chain Homo sapiens 7-17 25860295-6 2015 Bovine fibrinogen immobilized on CNBr-activated Sepharose 4B beads showed affinity for hemin, Sn-PPIX, Zn-PPIX, and iron-free PPIX in the order Sn-PPIX < iron-free PPIX < hemin < Zn-PPIX. zinc protoporphyrin 188-195 fibrinogen beta chain Homo sapiens 7-17 25860295-8 2015 These results suggest that bovine fibrinogen is a heme- and zinc-binding protein and that binding of circulating mammalian fibrinogen to ferritin is heme mediated. Heme 50-54 fibrinogen beta chain Homo sapiens 34-44 26006300-8 2015 Conversely, the FGB-p.Asp185Asn variant was demonstrated to be a gain-of-glycosylation mutation leading to a hyperglycosylation of the Bbeta chain, not affecting fibrinogen assembly and secretion. bbeta 135-140 fibrinogen beta chain Homo sapiens 16-19 25794141-4 2015 Here we transamidated the autofluorescent monoamine monodansylcadaverine (MDC) to purified plasma fibrinogen and to proteins from a primary glia cell culture. monodansylcadaverine 74-77 fibrinogen beta chain Homo sapiens 98-108 26251153-5 2015 A significant decrease in the Fg level was observed in the 2 mg/kg group (the median value before starting steroid treatment and that on the 20th day after starting steroid treatment were 506 mg/dl and 180 mg/dl, respectively, P=0.0013). Steroids 107-114 fibrinogen beta chain Homo sapiens 30-32 26251153-5 2015 A significant decrease in the Fg level was observed in the 2 mg/kg group (the median value before starting steroid treatment and that on the 20th day after starting steroid treatment were 506 mg/dl and 180 mg/dl, respectively, P=0.0013). Steroids 165-172 fibrinogen beta chain Homo sapiens 30-32 25811448-3 2015 Purified fibrinogen was mixed with vWF or Tris-buffered saline and clotted with thrombin - activated factor XIII. tris-buffered saline 42-62 fibrinogen beta chain Homo sapiens 9-19 26069112-8 2015 RESULTS: Fibrinogen levels were positively associated with IMT-max (standardized beta=0.25, p=0.021) and IMT-tpm (standardized beta=0.21, p=0.038), even after adjusting for age, body mass index, systolic blood pressure, fasting glucose, and total cholesterol to high-density lipoprotein cholesterol ratio in current smokers (n=75). Glucose 228-235 fibrinogen beta chain Homo sapiens 9-19 26293068-5 2015 RESULTS: MCFEXT and MCFINT showed good correlation with platelet count (r = 0.79 and 0.80, respectively, P < .001) and with fibrinogen concentration (r = 0.67 and 0.66, respectively, P < .001). mcfext 9-15 fibrinogen beta chain Homo sapiens 127-137 26293068-5 2015 RESULTS: MCFEXT and MCFINT showed good correlation with platelet count (r = 0.79 and 0.80, respectively, P < .001) and with fibrinogen concentration (r = 0.67 and 0.66, respectively, P < .001). mcfint 20-26 fibrinogen beta chain Homo sapiens 127-137 26069112-8 2015 RESULTS: Fibrinogen levels were positively associated with IMT-max (standardized beta=0.25, p=0.021) and IMT-tpm (standardized beta=0.21, p=0.038), even after adjusting for age, body mass index, systolic blood pressure, fasting glucose, and total cholesterol to high-density lipoprotein cholesterol ratio in current smokers (n=75). Cholesterol 247-258 fibrinogen beta chain Homo sapiens 9-19 26062547-1 2015 In this study, an attempt has been made to understand the organization and association of fibrinogen (Fg) in solvent environment induced by viscogens such as 1-ethyl 3-methyl imidazolium ethyl sulfate (IL-emes), Ficoll, and Trehalose. 1-ethyl-3-methylimidazolium 158-200 fibrinogen beta chain Homo sapiens 90-100 25651080-7 2015 Our study was mainly focused on the investigation of the fibrinogen (FGN) adsorption responsiveness both on homo polymer PNIPAAm brushes with and without the hydrophobic terminal functionalization, and further on binary brushes made of the polyelectrolyte poly(acrylic acid) (PAA) and one of the prior described two PNIPAAm species. carbopol 940 256-274 fibrinogen beta chain Homo sapiens 57-67 25651080-7 2015 Our study was mainly focused on the investigation of the fibrinogen (FGN) adsorption responsiveness both on homo polymer PNIPAAm brushes with and without the hydrophobic terminal functionalization, and further on binary brushes made of the polyelectrolyte poly(acrylic acid) (PAA) and one of the prior described two PNIPAAm species. carbopol 940 256-274 fibrinogen beta chain Homo sapiens 69-72 25651080-7 2015 Our study was mainly focused on the investigation of the fibrinogen (FGN) adsorption responsiveness both on homo polymer PNIPAAm brushes with and without the hydrophobic terminal functionalization, and further on binary brushes made of the polyelectrolyte poly(acrylic acid) (PAA) and one of the prior described two PNIPAAm species. carbopol 940 124-127 fibrinogen beta chain Homo sapiens 57-67 25651080-7 2015 Our study was mainly focused on the investigation of the fibrinogen (FGN) adsorption responsiveness both on homo polymer PNIPAAm brushes with and without the hydrophobic terminal functionalization, and further on binary brushes made of the polyelectrolyte poly(acrylic acid) (PAA) and one of the prior described two PNIPAAm species. carbopol 940 124-127 fibrinogen beta chain Homo sapiens 69-72 25651080-7 2015 Our study was mainly focused on the investigation of the fibrinogen (FGN) adsorption responsiveness both on homo polymer PNIPAAm brushes with and without the hydrophobic terminal functionalization, and further on binary brushes made of the polyelectrolyte poly(acrylic acid) (PAA) and one of the prior described two PNIPAAm species. poly-N-isopropylacrylamide 121-128 fibrinogen beta chain Homo sapiens 57-67 25651080-7 2015 Our study was mainly focused on the investigation of the fibrinogen (FGN) adsorption responsiveness both on homo polymer PNIPAAm brushes with and without the hydrophobic terminal functionalization, and further on binary brushes made of the polyelectrolyte poly(acrylic acid) (PAA) and one of the prior described two PNIPAAm species. poly-N-isopropylacrylamide 121-128 fibrinogen beta chain Homo sapiens 69-72 25651080-8 2015 The results show that the terminal hydrophobic modification of PNIPAAm has a considerable impact on wettability, LCST, and morphology of the homo and the binary brush systems, which consequently led to an alteration of FGN adsorption. poly-N-isopropylacrylamide 63-70 fibrinogen beta chain Homo sapiens 219-222 25651080-9 2015 By using binary PNIPAAm-PAA brushes with different composition it was possible to induce stimuli dependent FGN adsorption with a considerable amplified switching effect by introducing a hydrophobic terminal residue to PNIPAAm. poly-N-isopropylacrylamide 16-23 fibrinogen beta chain Homo sapiens 107-110 26059223-5 2015 RESULTS: Two peptides derived from the fibrinogen alpha chain, Arg573Cit (563-583) and Arg591Cit (580-600), referred to as Cit573 and Cit591, and two peptides from the fibrinogen beta chain, Arg72Cit (62-81) and Arg74Cit (62-81) (Cit72 and Cit74), displayed 65%, 15%, 35%, and 53% of immune reactivity among CCP2-positive RA sera, respectively. cit573 123-129 fibrinogen beta chain Homo sapiens 39-49 26059223-5 2015 RESULTS: Two peptides derived from the fibrinogen alpha chain, Arg573Cit (563-583) and Arg591Cit (580-600), referred to as Cit573 and Cit591, and two peptides from the fibrinogen beta chain, Arg72Cit (62-81) and Arg74Cit (62-81) (Cit72 and Cit74), displayed 65%, 15%, 35%, and 53% of immune reactivity among CCP2-positive RA sera, respectively. cit591 134-140 fibrinogen beta chain Homo sapiens 39-49 26059223-5 2015 RESULTS: Two peptides derived from the fibrinogen alpha chain, Arg573Cit (563-583) and Arg591Cit (580-600), referred to as Cit573 and Cit591, and two peptides from the fibrinogen beta chain, Arg72Cit (62-81) and Arg74Cit (62-81) (Cit72 and Cit74), displayed 65%, 15%, 35%, and 53% of immune reactivity among CCP2-positive RA sera, respectively. cit72 230-235 fibrinogen beta chain Homo sapiens 39-49 26059223-5 2015 RESULTS: Two peptides derived from the fibrinogen alpha chain, Arg573Cit (563-583) and Arg591Cit (580-600), referred to as Cit573 and Cit591, and two peptides from the fibrinogen beta chain, Arg72Cit (62-81) and Arg74Cit (62-81) (Cit72 and Cit74), displayed 65%, 15%, 35%, and 53% of immune reactivity among CCP2-positive RA sera, respectively. cit74 240-245 fibrinogen beta chain Homo sapiens 39-49 26062547-1 2015 In this study, an attempt has been made to understand the organization and association of fibrinogen (Fg) in solvent environment induced by viscogens such as 1-ethyl 3-methyl imidazolium ethyl sulfate (IL-emes), Ficoll, and Trehalose. 1-ethyl-3-methylimidazolium 158-200 fibrinogen beta chain Homo sapiens 102-104 26062547-1 2015 In this study, an attempt has been made to understand the organization and association of fibrinogen (Fg) in solvent environment induced by viscogens such as 1-ethyl 3-methyl imidazolium ethyl sulfate (IL-emes), Ficoll, and Trehalose. Trehalose 224-233 fibrinogen beta chain Homo sapiens 90-100 26062547-1 2015 In this study, an attempt has been made to understand the organization and association of fibrinogen (Fg) in solvent environment induced by viscogens such as 1-ethyl 3-methyl imidazolium ethyl sulfate (IL-emes), Ficoll, and Trehalose. Trehalose 224-233 fibrinogen beta chain Homo sapiens 102-104 26062547-6 2015 Scanning electron microscopy images show Fg in trehalose forms elongated bead like structures implying organization of the protein at the interface. Trehalose 47-56 fibrinogen beta chain Homo sapiens 41-43 25695403-11 2015 Plasma C-reactive protein and fibrinogen increased with MK-7123 treatment. 2-hydroxy-N,N-dimethyl-3-(2-((1-(5-methylfuran-2-yl)propyl)amino)-3,4-dioxocyclobut-1-enylamino)benzamide 56-63 fibrinogen beta chain Homo sapiens 30-40 25818241-7 2015 Moreover, ONOO(-) changes the structure and function of fibrinogen and proteins associated with fibrinolysis. onoo 10-14 fibrinogen beta chain Homo sapiens 56-66 25688462-0 2015 Homocysteine influences blood clot properties alone and in combination with total fibrinogen but not with fibrinogen gamma" in Africans. Homocysteine 0-12 fibrinogen beta chain Homo sapiens 82-92 25308126-6 2015 RESULTS: A statistically and clinically significant prolongation was observed for both APTT and PT between 29% and 43% K2 EDTA contamination, whereas the decrease of fibrinogen values became statistically and clinically significant at 43% K2 EDTA contamination. Edetic Acid 242-246 fibrinogen beta chain Homo sapiens 166-176 25955503-4 2015 The results revealed a typical behavior due to coagulation induced by calcium ions and the clotting time is Fbg concentration-dependent. Calcium 70-77 fibrinogen beta chain Homo sapiens 108-111 26007735-10 2015 The adsorption of the plasma proteins human serum albumin (HSA) and fibrinogen onto the polymer-coated surfaces were monitored. Polymers 88-95 fibrinogen beta chain Homo sapiens 44-78 25759104-16 2015 In conclusion, fibrinogen level was the major predictor of HPR on aspirin in this large population of high-risk vascular patients. Aspirin 66-73 fibrinogen beta chain Homo sapiens 15-25 25862345-3 2015 This study aimed to explore whether FXIII Val34Leu or beta-fibrinogen -455G/A gene polymorphisms are related to RSA. rabbit sperm membrane autoantigen 112-115 fibrinogen beta chain Homo sapiens 54-69 26044230-8 2015 The baseline information shows that stroke history (p = 0.002), fibrinogen (p = 0.036) and admission NIHSS score (M) (p = 0.001) for the BCI group are higher than the unilateral cerebellar infarct group. (E)-2-Benzylidene-3-(cyclohexylamino)-2,3-dihydro-1H-inden-1-one 137-140 fibrinogen beta chain Homo sapiens 64-74 25862345-6 2015 The odds ratio (OR) with 95% confidence interval (CI) was used to assess the association between RSA and FXIII Val34Leu and beta-fibrinogen -455G/A polymorphisms. rabbit sperm membrane autoantigen 97-100 fibrinogen beta chain Homo sapiens 124-139 25055247-4 2015 In addition, transferrin, fibrinogen and albumin were found to be associated with SDNs upon incubation. sdns 82-86 fibrinogen beta chain Homo sapiens 26-36 25660763-8 2015 The lysis time of clots made from purified fibrinogen of AAA-Asp was longer than that of AAA+Asp patients (756 +- 47 and 592 +- 52 s, respectively; P = 0.041). Aspartic Acid 61-64 fibrinogen beta chain Homo sapiens 43-53 25701629-0 2015 The influence of residual water on the secondary structure and crystallinity of freeze-dried fibrinogen. Water 26-31 fibrinogen beta chain Homo sapiens 93-103 26159014-10 2015 Plasma levels of Fg and D-D levels were negatively correlated with PaO2 (r = -0.493, r = -0.438, P < 0.01) before treatment, and also negatively correlated with PaO2 (r = -0.452, r = -0.325, P < 0.01, P < 0.05) after treatment, but they were not significantly correlated with PaCO2 before and after treatment (P >0.05). pao2 67-71 fibrinogen beta chain Homo sapiens 17-19 26159014-10 2015 Plasma levels of Fg and D-D levels were negatively correlated with PaO2 (r = -0.493, r = -0.438, P < 0.01) before treatment, and also negatively correlated with PaO2 (r = -0.452, r = -0.325, P < 0.01, P < 0.05) after treatment, but they were not significantly correlated with PaCO2 before and after treatment (P >0.05). pao2 164-168 fibrinogen beta chain Homo sapiens 17-19 25701629-1 2015 The purpose of this work was to investigate the influence of water content on the secondary structure of a freeze-dried protein (fibrinogen) after a storage period of two weeks. Water 61-66 fibrinogen beta chain Homo sapiens 129-139 26159014-10 2015 Plasma levels of Fg and D-D levels were negatively correlated with PaO2 (r = -0.493, r = -0.438, P < 0.01) before treatment, and also negatively correlated with PaO2 (r = -0.452, r = -0.325, P < 0.01, P < 0.05) after treatment, but they were not significantly correlated with PaCO2 before and after treatment (P >0.05). paco2 285-290 fibrinogen beta chain Homo sapiens 17-19 25908081-0 2015 Elevated serum fibrinogen: an independent link between diabetes mellitus, impaired on-clopidogrel platelet inhibition, and major adverse cardiac events after percutaneous coronary intervention. Clopidogrel 86-97 fibrinogen beta chain Homo sapiens 15-25 25897968-8 2015 Subgroup analyses of PAI-1, vWF% and fibrinogen in terms of trial drugs showed significant reductions for rosiglitazone (all p valuses< 0.05), but not pioglitazone treatment. Rosiglitazone 106-119 fibrinogen beta chain Homo sapiens 37-47 25908082-0 2015 Reply: elevated serum fibrinogen: an independent link between diabetes mellitus, impaired on-clopidogrel platelet inhibition, and major adverse cardiac events after percutaneous coronary intervention. Clopidogrel 93-104 fibrinogen beta chain Homo sapiens 22-32 25770497-2 2015 The effect of the heterogeneity of the polymer film surface on the nonspecific adsorption of the protein human plasma fibrinogen (FBN, 5.0 x 5.0 x 47.5 nm(3)) was investigated. Polymers 39-46 fibrinogen beta chain Homo sapiens 118-128 25613923-5 2015 AalphaC472S fibrinogen indicated the presence of additional disulfide-bonded molecules, and markedly impaired lateral aggregation of protofibrils in spite of slightly lower functional plasma fibrinogen levels. Disulfides 60-69 fibrinogen beta chain Homo sapiens 12-22 25613923-7 2015 Recombinant variant fibrinogen-producing cells demonstrated that destruction of the Aalpha442C-472C disulfide bond did not prevent the synthesis or secretion of fibrinogen, whereas the variant Aalpha chain of the secreted protein was degraded faster than that of the normal control. Disulfides 100-109 fibrinogen beta chain Homo sapiens 20-30 25613923-9 2015 The destruction and steric hindrance of the alphaC-domain of variant fibrinogen led to the impaired lateral aggregation of protofibrils and t-PA and plasminogen-mediated fibrinolysis, as well as several previously reported variants located in the alphaC-domain, and demonstrated the presence of disulfide-bonded molecules. Disulfides 295-304 fibrinogen beta chain Homo sapiens 69-79 25617832-0 2015 The influence of residual water on the solid-state properties of freeze-dried fibrinogen. Water 26-31 fibrinogen beta chain Homo sapiens 78-88 25046378-6 2015 All copolymers exhibited excellent resistance to fibrinogen adsorption and adsorbed more albumin than fibrinogen in the competitive adsorption assay, suggesting their good hemocompatibility. copolymers 4-14 fibrinogen beta chain Homo sapiens 49-59 25770497-3 2015 The kinetics of the FBN adsorption varies from a single-component Langmuir model on homogeneous hydrophilic PHEMA to a two-stage spreading relaxation model on homogeneous hydrophobic PS surface. Phosphorus 183-185 fibrinogen beta chain Homo sapiens 20-23 25770497-4 2015 On a heterogeneous PS-b-PHEMA surface with majority PS part, the initial FBN adsorption rate remains the same as that on the homogeneous PS surface. Phosphorus 19-21 fibrinogen beta chain Homo sapiens 73-76 25770497-7 2015 These interesting findings can be attributed to the enhancement of the spread FBN molecule in a mobile state by the heterogeneity of polymer film surface before irreversible adsorption occurs. Polymers 133-140 fibrinogen beta chain Homo sapiens 78-81 26675134-0 2015 Variation of fibrinogen oligosaccharide structure in the acute phase response: Possible haemorrhagic implications. Oligosaccharides 24-39 fibrinogen beta chain Homo sapiens 13-23 25609252-4 2015 When HEL cells were stimulated with thrombopoietin or phorbol 12-myristate 13-acetate (PMA), alphaIIbbeta3 became activated as evidenced by binding of an activation-specific monoclonal antibody and soluble fibrinogen, adherence and spreading on fibrinogen, colocalization of beta3 integrin and kindlin-3 in focal adhesions, and enhanced beta3 integrin-kindlin-3 association in immunoprecipitates. Tetradecanoylphorbol Acetate 54-85 fibrinogen beta chain Homo sapiens 206-216 25609252-4 2015 When HEL cells were stimulated with thrombopoietin or phorbol 12-myristate 13-acetate (PMA), alphaIIbbeta3 became activated as evidenced by binding of an activation-specific monoclonal antibody and soluble fibrinogen, adherence and spreading on fibrinogen, colocalization of beta3 integrin and kindlin-3 in focal adhesions, and enhanced beta3 integrin-kindlin-3 association in immunoprecipitates. Tetradecanoylphorbol Acetate 54-85 fibrinogen beta chain Homo sapiens 245-255 25609252-4 2015 When HEL cells were stimulated with thrombopoietin or phorbol 12-myristate 13-acetate (PMA), alphaIIbbeta3 became activated as evidenced by binding of an activation-specific monoclonal antibody and soluble fibrinogen, adherence and spreading on fibrinogen, colocalization of beta3 integrin and kindlin-3 in focal adhesions, and enhanced beta3 integrin-kindlin-3 association in immunoprecipitates. Tetradecanoylphorbol Acetate 87-90 fibrinogen beta chain Homo sapiens 206-216 25609252-4 2015 When HEL cells were stimulated with thrombopoietin or phorbol 12-myristate 13-acetate (PMA), alphaIIbbeta3 became activated as evidenced by binding of an activation-specific monoclonal antibody and soluble fibrinogen, adherence and spreading on fibrinogen, colocalization of beta3 integrin and kindlin-3 in focal adhesions, and enhanced beta3 integrin-kindlin-3 association in immunoprecipitates. Tetradecanoylphorbol Acetate 87-90 fibrinogen beta chain Homo sapiens 245-255 26675134-3 2015 To explore this, we examined the differences between the oligosaccharide structures of quiescent and acute phase fibrinogen. Oligosaccharides 57-72 fibrinogen beta chain Homo sapiens 113-123 26675134-6 2015 RESULTS: The Bbeta and gamma chains of acute phase fibrinogen showed a mass decrease of 162 Da (Gal) in some 50% of the molecules, and the Bbeta chain showed an additional decrease corresponding to a further loss of NAcGlc. bbeta 13-18 fibrinogen beta chain Homo sapiens 51-61 26675134-6 2015 RESULTS: The Bbeta and gamma chains of acute phase fibrinogen showed a mass decrease of 162 Da (Gal) in some 50% of the molecules, and the Bbeta chain showed an additional decrease corresponding to a further loss of NAcGlc. cyclohexenoesculetin-beta-galactoside 96-99 fibrinogen beta chain Homo sapiens 51-61 25547356-0 2015 Tigecycline treatment causes a decrease in fibrinogen levels. Tigecycline 0-11 fibrinogen beta chain Homo sapiens 43-53 25547356-1 2015 The objective of this study was to assess the impact of tigecycline treatment on coagulation parameters, specifically fibrinogen, in patients with severe infections. Tigecycline 56-67 fibrinogen beta chain Homo sapiens 118-128 25547356-4 2015 Fibrinogen (FIB) levels decreased significantly after the use of tigecycline and normalized after the cessation of treatment. Tigecycline 65-76 fibrinogen beta chain Homo sapiens 0-10 25547356-4 2015 Fibrinogen (FIB) levels decreased significantly after the use of tigecycline and normalized after the cessation of treatment. Tigecycline 65-76 fibrinogen beta chain Homo sapiens 12-15 25547356-11 2015 The use of tigecycline was associated with decreased FIB levels, which returned to normal after the cessation of treatment. Tigecycline 11-22 fibrinogen beta chain Homo sapiens 53-56 26307823-0 2015 Multi Drug Loaded Thermo-Responsive Fibrinogen-graft-Poly(N-vinyl Caprolactam) Nanogels for Breast Cancer Drug Delivery. poly-N-vinylcaprolactam 53-78 fibrinogen beta chain Homo sapiens 36-46 25123447-9 2015 Cabergoline was superior to bromocriptine in affecting 2-hr post-challenge plasma glucose levels, HOMA-IR, as well as circulating levels of IGF-1, FFA, uric acid, hsCRP, homocysteine, fibrinogen and 25-hydroxyvitamin D. Cabergoline 0-11 fibrinogen beta chain Homo sapiens 184-194 25577741-7 2015 RESULTS: Administration of sildenafil produced a significant sustained reduction of fibrinogen, hsCRP and hsIL-6 (maximal absolute response of -44mg/dl, 0.42mg/l and 0.68pg/ml at 4h). Sildenafil Citrate 27-37 fibrinogen beta chain Homo sapiens 84-94 25577741-9 2015 The effect of sildenafil on fibrinogen, hsCRP and hsIL-6 and TNF-alpha was independent of the baseline values of these markers/mediators or the baseline testosterone level (all P<0.05). Sildenafil Citrate 14-24 fibrinogen beta chain Homo sapiens 28-38 24802089-6 2015 Massive fibrinogen production was induced using a 5-mL radial flow bioreactor (RFB) while monitoring glucose metabolism. Glucose 101-108 fibrinogen beta chain Homo sapiens 8-18 24802089-8 2015 RESULTS: FLC-7 cell culture combined with IS-RPMI resulted in significantly better fibrinogen production (21.6 mug/10(7) cells per day). is-rpmi 42-49 fibrinogen beta chain Homo sapiens 83-93 24802089-9 2015 ASF104N had more positive effects on cell growth compared with IS-RPMI, whereas fibrinogen production was more efficient with IS-RPMI than with ASF104N. is-rpmi 126-133 fibrinogen beta chain Homo sapiens 80-90 24802089-9 2015 ASF104N had more positive effects on cell growth compared with IS-RPMI, whereas fibrinogen production was more efficient with IS-RPMI than with ASF104N. asf104n 144-151 fibrinogen beta chain Homo sapiens 80-90 26307823-1 2015 This study aims at the targeted delivery of 5-fluorouracil (5-FU) and Megestrol acetate (Meg) loaded fibrinogen-graft-poly(N-Vinyl caprolactam) nanogels (5-FU/Meg-fib-graft-PNVCL NGs) toward alpha5beta1-integrins receptors expressed on breast cancer cells to have enhanced anti-cancer effect in vitro. Megestrol Acetate 70-87 fibrinogen beta chain Homo sapiens 101-111 25709430-12 2015 However, only fibrinogen was a powerful predictor of suPAR in multiple linear regression. supar 53-58 fibrinogen beta chain Homo sapiens 14-24 25749850-3 2015 We developed a novel arginine-formulated fibrinogen from cryoprecipitates of porcine plasma. Arginine 21-29 fibrinogen beta chain Homo sapiens 41-51 25421744-4 2015 METHODS: Thrombin inactivation was modelled computationally by a reaction scheme with antithrombin, alpha(2) Macroglobulin and fibrinogen, taking into account the presence of the thrombin substrate ZGGR-AMC used to obtain the experimental data. zggr-amc 198-206 fibrinogen beta chain Homo sapiens 127-137 24860124-7 2015 RESULTS: After heparin neutralization, there were significantly elevated levels of fibrinogen in the FFP group, which were manifested by r-TEG parameters MAf and FLEV. Heparin 15-22 fibrinogen beta chain Homo sapiens 83-93 25564044-3 2015 Here, we explore interactions between common serum proteins - serum albumin, fibrinogen, and immunoglobulin G - and a nanotextured gallium nitride surface. gallium nitride 131-146 fibrinogen beta chain Homo sapiens 77-87 24550208-6 2015 RESULTS: Overall sitting time and TV viewing time were positively associated with plasma fibrinogen (sitting: beta: 0.02 g/L, 95% CI (0.01 to 0.02); TV time: 0.03 g/L (0.02 to 0.05)) and hsCRP (sitting: 2.4% (1.2% to 3.6%); TV time: 4.5% (1.7% to 7.4%)). hscrp 187-192 fibrinogen beta chain Homo sapiens 89-99 25705431-12 2015 This is the first report identifying low fibrinogen level among the risk factors for ICH in infants with PPHN on ECMO support. pphn 105-109 fibrinogen beta chain Homo sapiens 41-51 25542788-2 2015 Polyethylene glycol (PEG) hydrogels were formed with different protein constituents, including albumin, fibrinogen and gelatin. Polyethylene Glycols 0-19 fibrinogen beta chain Homo sapiens 104-114 25542788-2 2015 Polyethylene glycol (PEG) hydrogels were formed with different protein constituents, including albumin, fibrinogen and gelatin. Polyethylene Glycols 21-24 fibrinogen beta chain Homo sapiens 104-114 25542788-7 2015 Transverse MRI cross-sections of the implants revealed distinct mechanisms of the hydrogel"s biodegradation: PEG-Fibrinogen and PEG-Albumin underwent surface erosion, whereas PEG-Gelatin and PEG-DA hydrogels mainly underwent bulk degradation. Polyethylene Glycols 109-112 fibrinogen beta chain Homo sapiens 113-123 24820252-3 2015 Therefore, in this study our interest was to evaluate the bioactivity and blood biocompatibility of the SiO2 -CaO-P2 O5 glasses after their surface modification by functionalization with aminopropyl-triethoxysilane and/or by fibrinogen. sio2 -cao-p2 o5 104-119 fibrinogen beta chain Homo sapiens 225-235 25462849-0 2015 Injectable PEGylated fibrinogen cell-laden microparticles made with a continuous solvent- and oil-free preparation method. Oils 94-97 fibrinogen beta chain Homo sapiens 21-31 25462849-2 2015 A precursor solution of cells in photoreactive poly(ethylene glycol) (PEG)-fibrinogen (PF) polymer was transported through a transparent injector exposed to light irradiation before being atomized in a jet-in-air nozzle. Polyethylene Glycols 47-68 fibrinogen beta chain Homo sapiens 75-85 25462849-2 2015 A precursor solution of cells in photoreactive poly(ethylene glycol) (PEG)-fibrinogen (PF) polymer was transported through a transparent injector exposed to light irradiation before being atomized in a jet-in-air nozzle. Polymers 91-98 fibrinogen beta chain Homo sapiens 75-85 25280629-6 2015 Differently, incubation of fibrinogen or HSA/fibrinogen mixtures with HOCl at concentrations higher than 150 muM induced the formation of pentosidine and high molecular weight (HMW)-AOPPs (>200 k Da), resulting from intermolecular dityrosine cross-linking. Hypochlorous Acid 70-74 fibrinogen beta chain Homo sapiens 27-37 25533529-8 2015 Taken together, all the glycans contribute to the pharmacokinetics of acutobin and ATB-wt in vivo, and the microenvironment around the Asn(229)-glycan appears to regulate the fibrinogen-chain specificity of acutobin while the N-glycans at positions 77, 81 and 100 are crucial for its folding. Asparagine 135-138 fibrinogen beta chain Homo sapiens 175-185 25533529-8 2015 Taken together, all the glycans contribute to the pharmacokinetics of acutobin and ATB-wt in vivo, and the microenvironment around the Asn(229)-glycan appears to regulate the fibrinogen-chain specificity of acutobin while the N-glycans at positions 77, 81 and 100 are crucial for its folding. n-glycans 226-235 fibrinogen beta chain Homo sapiens 175-185 25413489-0 2015 A novel role for the fibrinogen Asn-Gly-Arg (NGR) motif in platelet function. NGR peptide 32-43 fibrinogen beta chain Homo sapiens 21-31 25632230-9 2015 Fib and Glbs showed the highest affinity to TiO2 NPs, while the lowest was seen for HSA. titanium dioxide 44-48 fibrinogen beta chain Homo sapiens 0-3 25785116-1 2015 BACKGROUND: A study had reported that a low TSH level is associated with elevated plasma fibrinogen (FIB) levels. Thyrotropin 44-47 fibrinogen beta chain Homo sapiens 89-99 25785116-1 2015 BACKGROUND: A study had reported that a low TSH level is associated with elevated plasma fibrinogen (FIB) levels. Thyrotropin 44-47 fibrinogen beta chain Homo sapiens 101-104 25280629-0 2015 A central role for intermolecular dityrosine cross-linking of fibrinogen in high molecular weight advanced oxidation protein product (AOPP) formation. dityrosine 34-44 fibrinogen beta chain Homo sapiens 62-72 25280629-6 2015 Differently, incubation of fibrinogen or HSA/fibrinogen mixtures with HOCl at concentrations higher than 150 muM induced the formation of pentosidine and high molecular weight (HMW)-AOPPs (>200 k Da), resulting from intermolecular dityrosine cross-linking. Hypochlorous Acid 70-74 fibrinogen beta chain Homo sapiens 45-55 25280629-6 2015 Differently, incubation of fibrinogen or HSA/fibrinogen mixtures with HOCl at concentrations higher than 150 muM induced the formation of pentosidine and high molecular weight (HMW)-AOPPs (>200 k Da), resulting from intermolecular dityrosine cross-linking. pentosidine 138-149 fibrinogen beta chain Homo sapiens 27-37 25280629-6 2015 Differently, incubation of fibrinogen or HSA/fibrinogen mixtures with HOCl at concentrations higher than 150 muM induced the formation of pentosidine and high molecular weight (HMW)-AOPPs (>200 k Da), resulting from intermolecular dityrosine cross-linking. pentosidine 138-149 fibrinogen beta chain Homo sapiens 45-55 25280629-6 2015 Differently, incubation of fibrinogen or HSA/fibrinogen mixtures with HOCl at concentrations higher than 150 muM induced the formation of pentosidine and high molecular weight (HMW)-AOPPs (>200 k Da), resulting from intermolecular dityrosine cross-linking. dityrosine 234-244 fibrinogen beta chain Homo sapiens 27-37 25280629-6 2015 Differently, incubation of fibrinogen or HSA/fibrinogen mixtures with HOCl at concentrations higher than 150 muM induced the formation of pentosidine and high molecular weight (HMW)-AOPPs (>200 k Da), resulting from intermolecular dityrosine cross-linking. dityrosine 234-244 fibrinogen beta chain Homo sapiens 45-55 25280629-7 2015 Dityrosine fluorescence increased in parallel with increasing HMW-AOPP formation and increasing fibrinogen concentration in HSA/fibrinogen mixtures exposed to HOCl. dityrosine 0-10 fibrinogen beta chain Homo sapiens 96-106 25280629-7 2015 Dityrosine fluorescence increased in parallel with increasing HMW-AOPP formation and increasing fibrinogen concentration in HSA/fibrinogen mixtures exposed to HOCl. dityrosine 0-10 fibrinogen beta chain Homo sapiens 128-138 25280629-7 2015 Dityrosine fluorescence increased in parallel with increasing HMW-AOPP formation and increasing fibrinogen concentration in HSA/fibrinogen mixtures exposed to HOCl. Hypochlorous Acid 159-163 fibrinogen beta chain Homo sapiens 96-106 25280629-7 2015 Dityrosine fluorescence increased in parallel with increasing HMW-AOPP formation and increasing fibrinogen concentration in HSA/fibrinogen mixtures exposed to HOCl. Hypochlorous Acid 159-163 fibrinogen beta chain Homo sapiens 128-138 25280629-8 2015 This conclusion is corroborated by experiments where dityrosine fluorescence was measured in HOCl-treated human plasma samples containing physiological or supra-physiological fibrinogen concentrations or selectively depleted of fibrinogen, which highlighted that fibrinogen is responsible for the highest fluorescence from dityrosine. dityrosine 53-63 fibrinogen beta chain Homo sapiens 175-185 25280629-8 2015 This conclusion is corroborated by experiments where dityrosine fluorescence was measured in HOCl-treated human plasma samples containing physiological or supra-physiological fibrinogen concentrations or selectively depleted of fibrinogen, which highlighted that fibrinogen is responsible for the highest fluorescence from dityrosine. dityrosine 53-63 fibrinogen beta chain Homo sapiens 228-238 25280629-8 2015 This conclusion is corroborated by experiments where dityrosine fluorescence was measured in HOCl-treated human plasma samples containing physiological or supra-physiological fibrinogen concentrations or selectively depleted of fibrinogen, which highlighted that fibrinogen is responsible for the highest fluorescence from dityrosine. dityrosine 53-63 fibrinogen beta chain Homo sapiens 228-238 25280629-8 2015 This conclusion is corroborated by experiments where dityrosine fluorescence was measured in HOCl-treated human plasma samples containing physiological or supra-physiological fibrinogen concentrations or selectively depleted of fibrinogen, which highlighted that fibrinogen is responsible for the highest fluorescence from dityrosine. Hypochlorous Acid 93-97 fibrinogen beta chain Homo sapiens 175-185 25280629-8 2015 This conclusion is corroborated by experiments where dityrosine fluorescence was measured in HOCl-treated human plasma samples containing physiological or supra-physiological fibrinogen concentrations or selectively depleted of fibrinogen, which highlighted that fibrinogen is responsible for the highest fluorescence from dityrosine. Hypochlorous Acid 93-97 fibrinogen beta chain Homo sapiens 228-238 25280629-8 2015 This conclusion is corroborated by experiments where dityrosine fluorescence was measured in HOCl-treated human plasma samples containing physiological or supra-physiological fibrinogen concentrations or selectively depleted of fibrinogen, which highlighted that fibrinogen is responsible for the highest fluorescence from dityrosine. Hypochlorous Acid 93-97 fibrinogen beta chain Homo sapiens 228-238 25280629-9 2015 CONCLUSIONS: A central role for intermolecular dityrosine cross-linking of fibrinogen in HMW-AOPP formation is shown. dityrosine 47-57 fibrinogen beta chain Homo sapiens 75-85 26406004-0 2015 Peroxynitrite induced fibrinogen site identification. Peroxynitrous Acid 0-13 fibrinogen beta chain Homo sapiens 22-32 26406004-1 2015 An increasing number of peroxynitrite-mediated fibrinogen nitrifications have been associated with thrombotic diseases. Peroxynitrous Acid 24-37 fibrinogen beta chain Homo sapiens 47-57 25280629-9 2015 CONCLUSIONS: A central role for intermolecular dityrosine cross-linking of fibrinogen in HMW-AOPP formation is shown. hmw-aopp 89-97 fibrinogen beta chain Homo sapiens 75-85 26406004-3 2015 In this paper, an improved method, which simulated the environment in vivo, was used to inspect the structural changes of fibrinogen treated with peroxynitrite and LC-MS/MS in order to investigate the fibrinogen injury sites. Peroxynitrous Acid 146-159 fibrinogen beta chain Homo sapiens 122-132 26406004-3 2015 In this paper, an improved method, which simulated the environment in vivo, was used to inspect the structural changes of fibrinogen treated with peroxynitrite and LC-MS/MS in order to investigate the fibrinogen injury sites. Peroxynitrous Acid 146-159 fibrinogen beta chain Homo sapiens 201-211 25280629-10 2015 GENERAL SIGNIFICANCE: These results highlight that oxidized fibrinogen, instead of HSA, is the key protein for intermolecular dityrosine formation in human plasma. dityrosine 126-136 fibrinogen beta chain Homo sapiens 60-70 23514971-2 2015 This study examined the relationship between hematocrit, blood viscosity, plasma viscosity, erythrocyte deformability, and fibrinogen concentration during maximal oxygen uptake in aerobically trained (AT) and resistance trained (RT) athletes. Oxygen 163-169 fibrinogen beta chain Homo sapiens 123-133 25919704-8 2015 In multiple regression analyses, fibrinogen was positively associated with serum peroxides (p < 0.001) in both ethnic groups. Peroxides 81-90 fibrinogen beta chain Homo sapiens 33-43 25491963-6 2015 Fibrinogen had excellent adsorption on titanium surfaces even at low concentrations, due to the binding ability of fibrinogen via its RGD motif. Titanium 39-47 fibrinogen beta chain Homo sapiens 0-10 26295816-0 2015 Chronic Migraineurs Form Carboxyhemefibrinogen and Iron-Bound Fibrinogen. Iron 51-55 fibrinogen beta chain Homo sapiens 62-72 26295816-3 2015 Further, CO and iron enhance plasmatic coagulation in part via a fibrinogen-dependent mechanism. Carbon Monoxide 9-11 fibrinogen beta chain Homo sapiens 65-75 26295816-3 2015 Further, CO and iron enhance plasmatic coagulation in part via a fibrinogen-dependent mechanism. Iron 16-20 fibrinogen beta chain Homo sapiens 65-75 25495665-8 2015 The single and dual protein adsorption studies showed that the amount of albumin and fibrinogen adsorbed on the alloy surfaces strongly depend on the type of PA and PAA coatings prepared by different concentrations of coating solutions. phosphoric acid 158-160 fibrinogen beta chain Homo sapiens 85-95 26118196-6 2015 RESULTS: There were significant correlations between SA and fibrinogen, D-dimer, factor (F) IX, and platelet (PLT) that were independent of smoking, body mass index (BMI), waist-to-hip ratio, hemoglobin A(1c) (HbA1c), fasting plasma glucose (FPG), triglycerides (TG), total cholesterol (TC) to high-density lipoprotein cholesterol (HDL-C) ratio, and antithrombotic therapy history. N-Acetylneuraminic Acid 53-55 fibrinogen beta chain Homo sapiens 60-70 26295816-11 2015 With regard to fibrinogen modification, 88.5% (69.8%-97.6%) of CM patients had formation of carboxyhemefibrinogen, iron bound fibrinogen, or both. carboxyhemefibrinogen 92-113 fibrinogen beta chain Homo sapiens 15-25 26540126-2 2015 This is a report of a novel fibrinogen point mutation (fibrinogen Innsbruck), a C/G point mutation at position 220 of exon two of the fibrinogen Bbeta-chain leading to BbetaArg44Gly. bbetaarg44gly 168-181 fibrinogen beta chain Homo sapiens 28-38 26540126-2 2015 This is a report of a novel fibrinogen point mutation (fibrinogen Innsbruck), a C/G point mutation at position 220 of exon two of the fibrinogen Bbeta-chain leading to BbetaArg44Gly. bbetaarg44gly 168-181 fibrinogen beta chain Homo sapiens 55-65 26540126-2 2015 This is a report of a novel fibrinogen point mutation (fibrinogen Innsbruck), a C/G point mutation at position 220 of exon two of the fibrinogen Bbeta-chain leading to BbetaArg44Gly. bbetaarg44gly 168-181 fibrinogen beta chain Homo sapiens 55-65 25951751-8 2015 We suggest that patients treated with tigecycline should be monitored for changes in INR, aPTT, and fibrinogen levels to avoid severe, life-threatening coagulation disturbances. Tigecycline 38-49 fibrinogen beta chain Homo sapiens 100-110 25836953-0 2015 Efficacy of fibrinogen concentrate compared with cryoprecipitate for reversal of the antiplatelet effect of clopidogrel in an in vitro model, as assessed by multiple electrode platelet aggregometry, thromboelastometry, and modified thromboelastography. Clopidogrel 108-119 fibrinogen beta chain Homo sapiens 12-22 25836953-2 2015 Whether increasing fibrinogen levels can restore hemostasis in this context is not established but may represent increased platelet glycoprotein fibrinogen binding, altered adenosine diphosphate (ADP)-dependent platelet activation, or an increase in formation of soluble fibrin as a component of whole blood clot. Adenosine Diphosphate 173-194 fibrinogen beta chain Homo sapiens 19-29 25836953-3 2015 DESIGN: The study hypothesis was that fibrinogen concentrate would normalize in vitro hemostatic parameters after clopidogrel loading. Clopidogrel 114-125 fibrinogen beta chain Homo sapiens 38-48 26160488-8 2015 Functional iron deficiency was associated with significantly higher serum levels of fibrinogen, ferritin, transferrin saturation, total iron binding capacity, hepcidin and older age relative to patients with absolute iron deficiency. Iron 11-15 fibrinogen beta chain Homo sapiens 84-94 25495665-8 2015 The single and dual protein adsorption studies showed that the amount of albumin and fibrinogen adsorbed on the alloy surfaces strongly depend on the type of PA and PAA coatings prepared by different concentrations of coating solutions. Phosphonoacetic Acid 165-168 fibrinogen beta chain Homo sapiens 85-95 25491963-6 2015 Fibrinogen had excellent adsorption on titanium surfaces even at low concentrations, due to the binding ability of fibrinogen via its RGD motif. Titanium 39-47 fibrinogen beta chain Homo sapiens 115-125 25491963-11 2015 These results suggest that the fibrinogen monolayer-modified titanium surface is recognized as bioactive scaffolds and promotes bone formation, resulting in the acceleration of osseointegration. Titanium 61-69 fibrinogen beta chain Homo sapiens 31-41 25231101-9 2015 The presence of dabigatran led to falsely reduced fibrinogen concentrations when measured with a low thrombin concentration reagent. Dabigatran 16-26 fibrinogen beta chain Homo sapiens 50-60 26688615-6 2015 RESULTS: In age- and sex-adjusted analysis, several inflammatory markers (WBC count, hs-CRP, fibrinogen, and ESR) were positively related to circulating non-HDL cholesterol and remnant cholesterol (p < 0.05, all). Cholesterol 161-172 fibrinogen beta chain Homo sapiens 93-103 26228833-6 2015 The EP3 agonist sulprostone caused an increase in the adhesion of washed platelets to fibrinogen as well as to collagen under low shear stress, an effect that was blocked by the EP3 antagonist L-798106. sulprostone 16-27 fibrinogen beta chain Homo sapiens 86-96 26228833-6 2015 The EP3 agonist sulprostone caused an increase in the adhesion of washed platelets to fibrinogen as well as to collagen under low shear stress, an effect that was blocked by the EP3 antagonist L-798106. 5-bromo-2-methoxy-N-(3-(naphthalen-2-yl-methylphenyl)acryloyl)benzenesulfonamide 193-201 fibrinogen beta chain Homo sapiens 86-96 25551457-1 2014 Plasma fibrinogen is an acute phase protein playing an important role in the blood coagulation cascade having strong associations with smoking, alcohol consumption and body mass index (BMI). Alcohols 144-151 fibrinogen beta chain Homo sapiens 7-17 32262085-4 2014 Protein (fibrinogen) uptake, osteoblast in vitro biocompatibility and corrosion resistance was enhanced in coatings containing TEP. triethyl phosphite 127-130 fibrinogen beta chain Homo sapiens 9-19 26123604-0 2015 Interaction of gamma-Fe2O3 nanoparticles with fibrinogen. gamma-fe2o3 15-26 fibrinogen beta chain Homo sapiens 46-56 26123604-1 2015 In this article, an attempt is made to analysis the binding mechanism of gamma-Fe2O3 nanoparticles with fibrinogen by using a combination of circular dichroism, UV-vis, fluorescence spectroscopic and computational methods. gamma-fe2o3 73-84 fibrinogen beta chain Homo sapiens 104-114 26123604-2 2015 The multi-spectroscopic data revealed that the complex easily formed between gamma-Fe2O3 nanoparticles and fibrinogen by mainly hydrogen bonding forces. gamma-fe2o3 77-88 fibrinogen beta chain Homo sapiens 107-117 26123604-2 2015 The multi-spectroscopic data revealed that the complex easily formed between gamma-Fe2O3 nanoparticles and fibrinogen by mainly hydrogen bonding forces. Hydrogen 128-136 fibrinogen beta chain Homo sapiens 107-117 26123604-3 2015 The binding constants of fibrinogen with gamma-Fe2O3 nanoparticles were 2.24x10(7), 1.15x10(7) and 0.72x10(7)Lmol(-1) at 298, 304, and 310K, respectively. gamma-fe2o3 41-52 fibrinogen beta chain Homo sapiens 25-35 26123604-4 2015 Furthermore, the results from circular dichroism, UV-vis, synchronous fluorescence, and three-dimensional fluorescence studies showed that the strong binding interaction of gamma-Fe2O3 nanoparticles with fibrinogen induced an obvious perturbation in the protein secondary and tertiary structure. gamma-fe2o3 173-184 fibrinogen beta chain Homo sapiens 204-214 26123604-5 2015 Moreover, the results of molecular modeling indicated the existence of the preferable binding site on fibrinogen for gamma-Fe2O3 NPs model. gamma-fe2o3 117-128 fibrinogen beta chain Homo sapiens 102-112 25224034-0 2014 Ozone-induced oxidative modification of fibrinogen: role of the D regions. Ozone 0-5 fibrinogen beta chain Homo sapiens 40-50 25103594-10 2014 This revealed the presence of a substitution Arg>Cys in position 275 of the gamma-chain of the fibrinogen. Arginine 45-48 fibrinogen beta chain Homo sapiens 98-108 25103594-10 2014 This revealed the presence of a substitution Arg>Cys in position 275 of the gamma-chain of the fibrinogen. Cysteine 52-55 fibrinogen beta chain Homo sapiens 98-108 25553877-0 2014 Fibrinogen adsorption and platelet adhesion to silica surfaces with stochastic nanotopography. Silicon Dioxide 47-53 fibrinogen beta chain Homo sapiens 0-10 25553877-2 2014 Nanorough silica surfaces with a low level of surface roughness (10 nm Rrms) were found to support the same level of fibrinogen adsorption as the planar silica surfaces, while nanorough silica surfaces with higher levels of surface roughness (15 nm Rrms) were found to support significantly less fibrinogen adsorption. Silicon Dioxide 10-16 fibrinogen beta chain Homo sapiens 117-127 25471221-7 2014 TG may also stimulate atherogenesis by mechanisms, such excessive free fatty acids (FFA) release, production of proinflammatory cytokines, fibrinogen, coagulation factors and impairment of fibrinolysis. Triglycerides 0-2 fibrinogen beta chain Homo sapiens 139-149 24991945-3 2014 A primary mechanism posited to explain iron-mediated hypercoagulability is hydroxyl radical formation and modification of fibrinogen; however, iron has also been demonstrated to bind to fibrinogen. Iron 39-43 fibrinogen beta chain Homo sapiens 122-132 24991945-3 2014 A primary mechanism posited to explain iron-mediated hypercoagulability is hydroxyl radical formation and modification of fibrinogen; however, iron has also been demonstrated to bind to fibrinogen. Iron 39-43 fibrinogen beta chain Homo sapiens 186-196 24991945-3 2014 A primary mechanism posited to explain iron-mediated hypercoagulability is hydroxyl radical formation and modification of fibrinogen; however, iron has also been demonstrated to bind to fibrinogen. Iron 143-147 fibrinogen beta chain Homo sapiens 186-196 24991945-6 2014 Thus, reversible iron binding to fibrinogen mechanistically explains a significant portion of coagulation kinetic and ultrastructural hypercoagulability. Iron 17-21 fibrinogen beta chain Homo sapiens 33-43 25224034-2 2014 The aim of this study was to investigate mechanisms of impairment of both the molecular structure and the spatial organization of fibrinogen under ozone-induced oxidation. Ozone 147-152 fibrinogen beta chain Homo sapiens 130-140 25224034-7 2014 The observed dissimilarities in the shapes of amide I bands of the fibrinogen D and E fragments before and after ozone treatment are interpreted in terms of feasible local conformational changes affecting the secondary structure of the protein. Amides 46-51 fibrinogen beta chain Homo sapiens 67-77 25224034-8 2014 Taken as a whole, the FTIR data suggests that the terminal D fragments of fibrinogen are markedly more susceptible to the ozone-induced oxidation than the central E fragment. Ozone 122-127 fibrinogen beta chain Homo sapiens 74-84 25224034-11 2014 The experimental data on fibrinogen oxidation acquired in the present study, combined with our earlier findings, make it reasonable to suppose that the spatial structure of fibrinogen could be evolutionarily adapted to some reactive oxygen species actions detrimental to the protein function. Reactive Oxygen Species 224-247 fibrinogen beta chain Homo sapiens 25-35 25224034-11 2014 The experimental data on fibrinogen oxidation acquired in the present study, combined with our earlier findings, make it reasonable to suppose that the spatial structure of fibrinogen could be evolutionarily adapted to some reactive oxygen species actions detrimental to the protein function. Reactive Oxygen Species 224-247 fibrinogen beta chain Homo sapiens 173-183 25330904-10 2014 Filamin A, an actin crosslinking phosphoprotein that is known to associate with beta3 , was dephosphorylated on Ser(2152) in fibrinogen-adhered wild-type but not in PP2B-Abeta(-/-) platelets. Serine 112-115 fibrinogen beta chain Homo sapiens 125-135 24443272-6 2014 Our PEG-grafted channels showed significantly reduced fibrinogen adsorption and platelet adhesion up to 28 days after application, highlighting the stability and functionality of the coating over time. Polyethylene Glycols 4-7 fibrinogen beta chain Homo sapiens 54-64 26089000-4 2014 Here, we evaluated the interaction of silica nanoparticles, a commonly used nanomaterial, with the human blood proteins albumin, transferrin, fibrinogen, and IgG. Silicon Dioxide 38-44 fibrinogen beta chain Homo sapiens 142-152 24510497-10 2014 Fibrinogen levels were directly related to AHI and arousal index and inversely related to mean and lowest oxygen saturation during sleep. Oxygen 106-112 fibrinogen beta chain Homo sapiens 0-10 24510497-11 2014 CONCLUSIONS: Severity of OSA was associated with increased fibrinogen level independent of other factors, suggesting that apneic events and oxygen desaturation during sleep are mechanisms for increased fibrinogen levels in patients with OSA. Oxygen 140-146 fibrinogen beta chain Homo sapiens 59-69 24510497-11 2014 CONCLUSIONS: Severity of OSA was associated with increased fibrinogen level independent of other factors, suggesting that apneic events and oxygen desaturation during sleep are mechanisms for increased fibrinogen levels in patients with OSA. Oxygen 140-146 fibrinogen beta chain Homo sapiens 202-212 25242664-3 2014 The changes induced upon adsorption of two model proteins with different geometries, trypsin (globular conformation) and fibrinogen (rod-shaped conformation) on poly-l-lactic acid (PLLA) scaffolds with different surface topographies, flat, fibrous and surfaces with aligned nanogrooves, were assessed by fluorescence spectroscopy monitoring, using tryptophan as structural probe. poly(lactide) 161-179 fibrinogen beta chain Homo sapiens 121-131 32481947-1 2014 Droplet microfluidics is combined with bio-orthogonal thiol-ene click chemistry to fabricate micrometer-sized, monodisperse fibrinogen-containing hyaluronic acid hydrogel microbeads in a mild, radical-free procedure in the presence of human mesenchymal stem cells (hMSCs). Sulfhydryl Compounds 54-59 fibrinogen beta chain Homo sapiens 124-134 32481947-1 2014 Droplet microfluidics is combined with bio-orthogonal thiol-ene click chemistry to fabricate micrometer-sized, monodisperse fibrinogen-containing hyaluronic acid hydrogel microbeads in a mild, radical-free procedure in the presence of human mesenchymal stem cells (hMSCs). ene 60-63 fibrinogen beta chain Homo sapiens 124-134 32481947-1 2014 Droplet microfluidics is combined with bio-orthogonal thiol-ene click chemistry to fabricate micrometer-sized, monodisperse fibrinogen-containing hyaluronic acid hydrogel microbeads in a mild, radical-free procedure in the presence of human mesenchymal stem cells (hMSCs). Hyaluronic Acid 146-161 fibrinogen beta chain Homo sapiens 124-134 25242664-3 2014 The changes induced upon adsorption of two model proteins with different geometries, trypsin (globular conformation) and fibrinogen (rod-shaped conformation) on poly-l-lactic acid (PLLA) scaffolds with different surface topographies, flat, fibrous and surfaces with aligned nanogrooves, were assessed by fluorescence spectroscopy monitoring, using tryptophan as structural probe. poly(lactide) 181-185 fibrinogen beta chain Homo sapiens 121-131 25242664-3 2014 The changes induced upon adsorption of two model proteins with different geometries, trypsin (globular conformation) and fibrinogen (rod-shaped conformation) on poly-l-lactic acid (PLLA) scaffolds with different surface topographies, flat, fibrous and surfaces with aligned nanogrooves, were assessed by fluorescence spectroscopy monitoring, using tryptophan as structural probe. Tryptophan 348-358 fibrinogen beta chain Homo sapiens 121-131 24330130-13 2014 Serum homocysteine correlated with both serum hs-CRP and serum fibrinogen. Homocysteine 6-18 fibrinogen beta chain Homo sapiens 63-73 25397464-10 2014 The fibrinogen was positively associated with dRoms (p=0.052) and the positive correlation between triglycerides and antiRoms has been confirmed (p<0.001); the impact of antiRoms on HDL/triglycerides ratio (p=0.006) was observed after adjustment for PI use. Triglycerides 189-202 fibrinogen beta chain Homo sapiens 4-14 24946826-7 2014 BOP was the only periodontal parameter significantly associated with each systemic parameter (CRP, FIB, and WBC). bop 0-3 fibrinogen beta chain Homo sapiens 99-102 25731059-3 2014 She suffered multiple right brain infarctions, a pulmonary embolism, a right renal infarction with bilateral hydronephrosis and deep venous thromboses and exhibited increased D-dimer and fibrinogen levels and so was administered heparin (10,000 U x day(-1)). Heparin 229-236 fibrinogen beta chain Homo sapiens 187-197 32481910-1 2014 Graphene oxide (GO) modified with 29-mer thrombin-binding-aptamer-conjugated gold nanoparticles (TBA29-Au NPs/GO) can synergistically inhibit the thrombin-mediated cleavage of fibrinogen to fibrin. graphene oxide 0-14 fibrinogen beta chain Homo sapiens 176-186 24981072-7 2014 In comparison with that of pSS patients without ILD, significantly higher levels of ESR, CRP, FIB, IgG, C3 and lower ALB were detected in pSS patients with ILD. pss 138-141 fibrinogen beta chain Homo sapiens 94-97 25112907-6 2014 This surfactant reduces the inhibitory effect of fibrinogen by selectively interacting with DPPC (dipalmitoylphosphatidylcholine) and mimicking some of the interfacial properties of the pulmonary surfactant protein B (SP-B). 1,2-Dipalmitoylphosphatidylcholine 92-96 fibrinogen beta chain Homo sapiens 49-59 25112907-6 2014 This surfactant reduces the inhibitory effect of fibrinogen by selectively interacting with DPPC (dipalmitoylphosphatidylcholine) and mimicking some of the interfacial properties of the pulmonary surfactant protein B (SP-B). 1,2-Dipalmitoylphosphatidylcholine 98-128 fibrinogen beta chain Homo sapiens 49-59 25112907-8 2014 Hysteresis behaviors of the monolayers, which are composed of mixtures of DPPC and IPL at different molar ratios, indicate that with increasing amounts of IPL, the lipid losses from the interface induced by the presence of fibrinogen significantly decrease. 1,2-Dipalmitoylphosphatidylcholine 74-78 fibrinogen beta chain Homo sapiens 223-233 25172575-0 2014 The effect of full/partial UV-irradiation of TiO2 films on altering the behavior of fibrinogen and platelets. titanium dioxide 45-49 fibrinogen beta chain Homo sapiens 84-94 25172575-4 2014 This study attempts to determine: (1) whether UV-irradiation of TiO2 films enhances their blood compatibility, (2) the interaction between UV-irradiated TiO2 films, fibrinogen (Fgn), and platelets, especially how Fgn and platelets respond to the geometry of the partially UV-irradiated TiO2 film surface. titanium dioxide 64-68 fibrinogen beta chain Homo sapiens 165-175 25172575-6 2014 Full UV-irradiation improved the blood compatibility of TiO2 films by almost completely inhibiting the adhesion and activation of platelets, strongly suppressing the adsorption and conformational change of Fgn, and preventing the formation of fibrin fibers. titanium dioxide 56-60 fibrinogen beta chain Homo sapiens 206-209 25172575-8 2014 After partial UV-irradiation, the regions where Fgn adsorption was reduced (Fgn-dark regions) were formed at regions where UV-irradiation had occurred, but were extended in comparison with the UV-irradiated regions, which could be related to the generation and diffusion of reactive oxygen species (ROS) on the UV-irradiated TiO2 surface. Reactive Oxygen Species 274-297 fibrinogen beta chain Homo sapiens 48-51 25726193-6 2014 Across tertiles of fibrinogen (low and high), there was an increase in cholesterol, adjusted for age and body mass index (4.9+-0.9 mmol/L vs 5.4+-1.1 mmol/L, p< 0.01). Cholesterol 71-82 fibrinogen beta chain Homo sapiens 19-29 25726193-10 2014 Significant positive correlations were observed between fibrinogen and cholesterol (r=0.198, p<0.001) and triglycerides (r=0.116, p<0.05). Cholesterol 71-82 fibrinogen beta chain Homo sapiens 56-66 25172575-8 2014 After partial UV-irradiation, the regions where Fgn adsorption was reduced (Fgn-dark regions) were formed at regions where UV-irradiation had occurred, but were extended in comparison with the UV-irradiated regions, which could be related to the generation and diffusion of reactive oxygen species (ROS) on the UV-irradiated TiO2 surface. Reactive Oxygen Species 274-297 fibrinogen beta chain Homo sapiens 76-79 25172575-8 2014 After partial UV-irradiation, the regions where Fgn adsorption was reduced (Fgn-dark regions) were formed at regions where UV-irradiation had occurred, but were extended in comparison with the UV-irradiated regions, which could be related to the generation and diffusion of reactive oxygen species (ROS) on the UV-irradiated TiO2 surface. Reactive Oxygen Species 299-302 fibrinogen beta chain Homo sapiens 48-51 25172575-8 2014 After partial UV-irradiation, the regions where Fgn adsorption was reduced (Fgn-dark regions) were formed at regions where UV-irradiation had occurred, but were extended in comparison with the UV-irradiated regions, which could be related to the generation and diffusion of reactive oxygen species (ROS) on the UV-irradiated TiO2 surface. Reactive Oxygen Species 299-302 fibrinogen beta chain Homo sapiens 76-79 25172575-8 2014 After partial UV-irradiation, the regions where Fgn adsorption was reduced (Fgn-dark regions) were formed at regions where UV-irradiation had occurred, but were extended in comparison with the UV-irradiated regions, which could be related to the generation and diffusion of reactive oxygen species (ROS) on the UV-irradiated TiO2 surface. titanium dioxide 325-329 fibrinogen beta chain Homo sapiens 48-51 25172575-8 2014 After partial UV-irradiation, the regions where Fgn adsorption was reduced (Fgn-dark regions) were formed at regions where UV-irradiation had occurred, but were extended in comparison with the UV-irradiated regions, which could be related to the generation and diffusion of reactive oxygen species (ROS) on the UV-irradiated TiO2 surface. titanium dioxide 325-329 fibrinogen beta chain Homo sapiens 76-79 25172575-10 2014 Furthermore, platelets were found adhering to the Fgn-adsorbed regions (Fgn-bright regions) selectively, suggesting that the inhibition of platelet adhesion could be related to the suppression of Fgn adsorption on the UV-irradiated TiO2 surface. titanium dioxide 232-236 fibrinogen beta chain Homo sapiens 50-53 25172575-10 2014 Furthermore, platelets were found adhering to the Fgn-adsorbed regions (Fgn-bright regions) selectively, suggesting that the inhibition of platelet adhesion could be related to the suppression of Fgn adsorption on the UV-irradiated TiO2 surface. titanium dioxide 232-236 fibrinogen beta chain Homo sapiens 72-75 25172575-10 2014 Furthermore, platelets were found adhering to the Fgn-adsorbed regions (Fgn-bright regions) selectively, suggesting that the inhibition of platelet adhesion could be related to the suppression of Fgn adsorption on the UV-irradiated TiO2 surface. titanium dioxide 232-236 fibrinogen beta chain Homo sapiens 72-75 24929049-6 2014 Moreover, the aim of our study was to establish the influence of NaHS (10 muM; 5, 15 and 30 min) on the clot formation using the purified fibrinogen. sodium bisulfide 65-69 fibrinogen beta chain Homo sapiens 138-148 26461400-0 2014 Mapping nitro-tyrosine modifications in fibrinogen by mass spectrometry as a biomarker for inflammatory disease. nitro 8-13 fibrinogen beta chain Homo sapiens 40-50 26461400-0 2014 Mapping nitro-tyrosine modifications in fibrinogen by mass spectrometry as a biomarker for inflammatory disease. Tyrosine 14-22 fibrinogen beta chain Homo sapiens 40-50 26461400-4 2014 The aim of this study was to map tyrosine nitration in fibrinogen under oxidative conditions and identify susceptible residues. Tyrosine 33-41 fibrinogen beta chain Homo sapiens 55-65 26461400-5 2014 Fibrinogen was oxidised with 0.25mM and 1mM SIN-1, a peroxynitrite generator, and methionine was used to quench excess oxidant in the samples. Peroxynitrous Acid 53-66 fibrinogen beta chain Homo sapiens 0-10 26461400-5 2014 Fibrinogen was oxidised with 0.25mM and 1mM SIN-1, a peroxynitrite generator, and methionine was used to quench excess oxidant in the samples. Methionine 82-92 fibrinogen beta chain Homo sapiens 0-10 25027687-10 2014 Both increased plasma fibrinogen and d-dimer levels predicted decreased DFS (P = 0.027 and 0.04), CSS (P = 0.007 and 0.043), and OS (P = 0.014 and 0.001) rates based on Kaplan-Meier analyses. thiocysteine 98-101 fibrinogen beta chain Homo sapiens 22-32 25157934-0 2014 Human fibrinogen adsorption on positively charged latex particles. Latex 50-55 fibrinogen beta chain Homo sapiens 6-16 25157934-4 2014 A monotonic decrease in the electrophoretic mobility of fibrinogen-covered latex was observed for all ionic strengths. Latex 75-80 fibrinogen beta chain Homo sapiens 56-66 25082449-6 2014 The kinetics of fibrinogen/fibrin polymer formation was monitored by turbidity change, SDS-PAGE, and electron microscopy. Sodium Dodecyl Sulfate 87-90 fibrinogen beta chain Homo sapiens 16-26 25231271-12 2014 Patients with total amount of CTO exceeding 75th percentile were more frequently transfused with fresh frozen plasma (51.4% vs. 9.9%, p < 0.001), fibrinogen concentrate (21.6% vs. 2.7%, p = 0.001) and platelet concentrate (13.5% vs. 0.9%, p = 0.004). cto 30-33 fibrinogen beta chain Homo sapiens 149-159 24929049-9 2014 We observed that NaHS (0.01-100 muM) reduced fibrin polymerization in whole plasma and 10 muM NaHS also reduced polymerization of purified fibrinogen. sodium bisulfide 94-98 fibrinogen beta chain Homo sapiens 139-149 24558180-5 2014 An interquartile range (IQR) increase in NO2 exposure in lag 5 was associated with 51%, 10% and 9% increases in CRP, fibrinogen and HGF levels respectively. Nitrogen Dioxide 41-44 fibrinogen beta chain Homo sapiens 117-127 24592919-0 2014 Coagulation assays and plasma fibrinogen concentrations in real-world patients with atrial fibrillation treated with dabigatran. Dabigatran 117-127 fibrinogen beta chain Homo sapiens 30-40 24592919-7 2014 Plasma fibrinogen concentrations explained some of the residual variability in TT values after taking plasma dabigatran concentrations into account (r(2) = 0.12, P = 0.02). Dabigatran 109-119 fibrinogen beta chain Homo sapiens 7-17 24964786-8 2014 Attenuation of decay only in part explains the stimulating effect of fibrinogen on TG, as fibrinogen stimulates prothrombin conversion, regardless of the fibrinogen variant. Thioguanine 83-85 fibrinogen beta chain Homo sapiens 69-79 24867207-14 2014 Finally, we demonstrated that fibrinogen interacts with transthyretin and alpha-synuclein in TCL lysates. Triclosan 93-96 fibrinogen beta chain Homo sapiens 30-40 26413083-4 2014 Citrated human plasma was used to evaluate the clotting time whereas changes in fibrinogen molecules were visualized by electrophoresis in polyacrylamide gel. polyacrylamide 139-153 fibrinogen beta chain Homo sapiens 80-90 24859537-2 2014 Under in vitro conditions, SufA is capable of human fibrinogen hydrolysis leading to inhibition of fibrin network formation, thus suggesting its important role in the development and progression of Finegoldia magna infections. sufa 27-31 fibrinogen beta chain Homo sapiens 52-62 25001594-2 2014 We describe in this work a novel electrochemical immunosensor design making use of carbon nanohorns (CNHs) as a scaffold for the preparation of disposable immunosensing platforms for the determination of fibrinogen (Fib). Carbon 83-89 fibrinogen beta chain Homo sapiens 204-214 25001594-2 2014 We describe in this work a novel electrochemical immunosensor design making use of carbon nanohorns (CNHs) as a scaffold for the preparation of disposable immunosensing platforms for the determination of fibrinogen (Fib). Carbon 83-89 fibrinogen beta chain Homo sapiens 216-219 25001594-3 2014 The approach involved the immobilization of Fib onto activated CNHs deposited on screen-printed carbon electrodes (SPCEs) and the implementation of an indirect competitive assay using anti-Fib labeled with horseradish peroxidase (HRP) and hydroquinone (HQ) as the redox mediator. Carbon 96-102 fibrinogen beta chain Homo sapiens 44-47 24859537-8 2014 In addition, it prevented SufA-mediated human fibrinogen hydrolysis in vitro and exhibited potent antibacterial activity against F. magna, Staphylococcus aureus and Escherichia coli. sufa 26-30 fibrinogen beta chain Homo sapiens 46-56 24398441-6 2014 RESULTS: For saline and gelatin dilutions, plasma fibrinogen and thromboelastometry parameters normalized by fibrinogen concentrate, while conventional coagulation assays and factors V and VIII remained unaffectedly impaired. Sodium Chloride 13-19 fibrinogen beta chain Homo sapiens 50-60 24398441-6 2014 RESULTS: For saline and gelatin dilutions, plasma fibrinogen and thromboelastometry parameters normalized by fibrinogen concentrate, while conventional coagulation assays and factors V and VIII remained unaffectedly impaired. Sodium Chloride 13-19 fibrinogen beta chain Homo sapiens 109-119 24398441-8 2014 For hydroxyethyl starch dilutions, plasma fibrinogen increased by fresh frozen plasma, and even normalized by fibrinogen concentrate. Hydroxyethyl starch 4-23 fibrinogen beta chain Homo sapiens 42-52 24984998-12 2014 CONCLUSION: A low-calorie, low-carbohydrate soy-containing diet could have beneficial effects on liver enzymes, malondialdehyde, and serum fibrinogen levels in patients with NAFLD. low-carbohydrate 27-43 fibrinogen beta chain Homo sapiens 139-149 27128831-3 2014 Bazedoxifene demonstrated a half-life of 25 to 30 hours, reached steady state within 7 days, and exhibited linear pharmacokinetics over a dose range of 5-80 mg. Fibrinogen levels decreased with bazedoxifene doses of 5 mg and greater; these changes were significant for bazedoxifene 20, 40, and 80 mg (P <= .05 vs placebo), but were not dose dependent. bazedoxifene 0-12 fibrinogen beta chain Homo sapiens 161-171 27128831-3 2014 Bazedoxifene demonstrated a half-life of 25 to 30 hours, reached steady state within 7 days, and exhibited linear pharmacokinetics over a dose range of 5-80 mg. Fibrinogen levels decreased with bazedoxifene doses of 5 mg and greater; these changes were significant for bazedoxifene 20, 40, and 80 mg (P <= .05 vs placebo), but were not dose dependent. bazedoxifene 194-206 fibrinogen beta chain Homo sapiens 161-171 27128831-3 2014 Bazedoxifene demonstrated a half-life of 25 to 30 hours, reached steady state within 7 days, and exhibited linear pharmacokinetics over a dose range of 5-80 mg. Fibrinogen levels decreased with bazedoxifene doses of 5 mg and greater; these changes were significant for bazedoxifene 20, 40, and 80 mg (P <= .05 vs placebo), but were not dose dependent. bazedoxifene 269-281 fibrinogen beta chain Homo sapiens 161-171 25346984-4 2014 The application of low-molecular heparins (Klexan and Fraxiparine) prior to operation and during post-operative period decreases activation of pro-coagulant (prolongation of activated partial thromboplastin time, pro-prothrombin activity and concentration of fibrinogen) and platelet-derived components of system of hemostasis, level of markers of intravascular coagulation of blood, von Willebrand factor. Heparin 33-41 fibrinogen beta chain Homo sapiens 259-269 25346984-4 2014 The application of low-molecular heparins (Klexan and Fraxiparine) prior to operation and during post-operative period decreases activation of pro-coagulant (prolongation of activated partial thromboplastin time, pro-prothrombin activity and concentration of fibrinogen) and platelet-derived components of system of hemostasis, level of markers of intravascular coagulation of blood, von Willebrand factor. klexan 43-49 fibrinogen beta chain Homo sapiens 259-269 25346984-4 2014 The application of low-molecular heparins (Klexan and Fraxiparine) prior to operation and during post-operative period decreases activation of pro-coagulant (prolongation of activated partial thromboplastin time, pro-prothrombin activity and concentration of fibrinogen) and platelet-derived components of system of hemostasis, level of markers of intravascular coagulation of blood, von Willebrand factor. Nadroparin 54-65 fibrinogen beta chain Homo sapiens 259-269 24962680-7 2014 The regression analysis adjusted for fibrinogen showed that in hyperthyroid patients, pre-treatment thyroid stimulating hormone (TSH) independently predicted Ks, while thrombin activatable fibrinolysis inhibitor (TAFI) antigen predicted CLT. Thyrotropin 129-132 fibrinogen beta chain Homo sapiens 37-47 24904056-3 2014 We characterized here a novel fibrinogen-binding protein of GBS, designated FbsC (Gbs0791), which is encoded by the prototype GBS strain NEM316. gbs0791 82-89 fibrinogen beta chain Homo sapiens 30-40 24202701-3 2014 Here, we present a case of a consumptive coagulopathy due to a large venous malformation with a sustained correction of the fibrinogen depletion and associated bleeding tendency both with subcutaneous enoxaparin and with the oral factor Xa inhibitor rivaroxaban. Rivaroxaban 250-261 fibrinogen beta chain Homo sapiens 124-134 25038212-1 2014 The mutation gamma375Arg Trp (fibrinogen Aguadilla) is one of four mutations (Brescia, Aguadilla, Angers, and AI duPont) capable of causing hepatic storage of fibrinogen. Tryptophan 27-30 fibrinogen beta chain Homo sapiens 161-171 25038212-1 2014 The mutation gamma375Arg Trp (fibrinogen Aguadilla) is one of four mutations (Brescia, Aguadilla, Angers, and AI duPont) capable of causing hepatic storage of fibrinogen. Tryptophan 27-30 fibrinogen beta chain Homo sapiens 32-42 24945257-10 2014 Taken together, our results suggest that the conjugated glycans of acutobin are involved in its interaction with fibrinogen, and that the selection of cells optimally expressing efficient glycoforms and further glycosylation engineering are desirable before a recombinant product can replace the native enzyme for clinical use. Polysaccharides 56-63 fibrinogen beta chain Homo sapiens 113-123 32263799-4 2014 It could be demonstrated that, by performing surface grafting with oligo- and polyglycerols of relatively high polydispersity (>1.5) and several reactive groups for surface anchoring, full surface shielding can be reached, which leads to reduced protein adsorption of albumin and fibrinogen. oligo- and polyglycerols 67-91 fibrinogen beta chain Homo sapiens 280-290 24460692-7 2014 However, physical removal of dissolved oxygen prior to RF-PRT protects ADAMTS13 as well as FVIII and fibrinogen from damage, indicating a direct role for reactive oxygen species. Oxygen 39-45 fibrinogen beta chain Homo sapiens 101-111 24384913-3 2014 Molecular studies identified the presence of a 554Arg Cys mutation in the fibrinogen Aalpha gene, previously identified as Fibrinogen Dusart (also known as Fibrinogen Paris V and Fibrinogen Chapel Hill). Cysteine 54-57 fibrinogen beta chain Homo sapiens 74-84 24384913-3 2014 Molecular studies identified the presence of a 554Arg Cys mutation in the fibrinogen Aalpha gene, previously identified as Fibrinogen Dusart (also known as Fibrinogen Paris V and Fibrinogen Chapel Hill). Cysteine 54-57 fibrinogen beta chain Homo sapiens 123-133 24384913-3 2014 Molecular studies identified the presence of a 554Arg Cys mutation in the fibrinogen Aalpha gene, previously identified as Fibrinogen Dusart (also known as Fibrinogen Paris V and Fibrinogen Chapel Hill). Cysteine 54-57 fibrinogen beta chain Homo sapiens 156-166 24384913-3 2014 Molecular studies identified the presence of a 554Arg Cys mutation in the fibrinogen Aalpha gene, previously identified as Fibrinogen Dusart (also known as Fibrinogen Paris V and Fibrinogen Chapel Hill). Cysteine 54-57 fibrinogen beta chain Homo sapiens 156-166 24708538-0 2014 Distinct adsorption configurations and self-assembly characteristics of fibrinogen on chemically uniform and alternating surfaces including block copolymer nanodomains. copolymer 146-155 fibrinogen beta chain Homo sapiens 72-82 24708538-3 2014 In this study, we examine the adsorption and assembly behavior of a highly elongated protein, fibrinogen, on both chemically uniform (as-is and buffered HF-treated SiO2/Si, and homopolymers of polystyrene and poly(methyl methacrylate)) and varying (polystyrene-block-poly(methyl methacrylate)) surfaces. Hafnium 153-155 fibrinogen beta chain Homo sapiens 94-104 24708538-3 2014 In this study, we examine the adsorption and assembly behavior of a highly elongated protein, fibrinogen, on both chemically uniform (as-is and buffered HF-treated SiO2/Si, and homopolymers of polystyrene and poly(methyl methacrylate)) and varying (polystyrene-block-poly(methyl methacrylate)) surfaces. Silicon Dioxide 164-168 fibrinogen beta chain Homo sapiens 94-104 24708538-3 2014 In this study, we examine the adsorption and assembly behavior of a highly elongated protein, fibrinogen, on both chemically uniform (as-is and buffered HF-treated SiO2/Si, and homopolymers of polystyrene and poly(methyl methacrylate)) and varying (polystyrene-block-poly(methyl methacrylate)) surfaces. Silicon 164-166 fibrinogen beta chain Homo sapiens 94-104 24708538-5 2014 By exploiting block copolymer nanodomains whose repeat distance is commensurate with the length of the individual protein, we determine that fibrinogen exhibits a more neutral tendency for interaction with both polystyrene and poly(methyl methacrylate) blocks relative to the case of common globular proteins. copolymer 20-29 fibrinogen beta chain Homo sapiens 141-151 24708538-5 2014 By exploiting block copolymer nanodomains whose repeat distance is commensurate with the length of the individual protein, we determine that fibrinogen exhibits a more neutral tendency for interaction with both polystyrene and poly(methyl methacrylate) blocks relative to the case of common globular proteins. Polystyrenes 211-222 fibrinogen beta chain Homo sapiens 141-151 24708538-5 2014 By exploiting block copolymer nanodomains whose repeat distance is commensurate with the length of the individual protein, we determine that fibrinogen exhibits a more neutral tendency for interaction with both polystyrene and poly(methyl methacrylate) blocks relative to the case of common globular proteins. Polymethyl Methacrylate 227-252 fibrinogen beta chain Homo sapiens 141-151 24708538-9 2014 On the basis of two-dimensional stacking behavior, a protein assembly model is proposed for the formation of an extended fibrinogen network on the diblock copolymer. diblock copolymer 147-164 fibrinogen beta chain Homo sapiens 121-131 24714688-3 2014 Here we summarize recent microscopy-based observations to the effect that iron can have major effects on erythrocyte morphology, on erythrocyte deformability and on both fibrinogen polymerization and the consequent structure of the fibrin clots formed, each of which contributes significantly and negatively to such diseases. Iron 74-78 fibrinogen beta chain Homo sapiens 170-180 24931842-9 2014 Mean levels of fibrinogen after methylene blue/light treatment exceeded 200 mg/dL in all arms. Methylene Blue 32-46 fibrinogen beta chain Homo sapiens 15-25 25050219-3 2014 We argue that upon contact with redox iron, fibrinogen is converted to a hydrophobic fibrin-like polymer that coats tumor cells and provides protection from immune-mediated destruction. Iron 38-42 fibrinogen beta chain Homo sapiens 44-54 24770447-2 2014 We therefore aimed to investigate whether fibrinogen plasma concentrations a) are elevated in pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH) and b) may serve as a novel biomarker for haemodynamic impairment. cteph 183-188 fibrinogen beta chain Homo sapiens 42-52 24770447-5 2014 Furthermore, fibrinogen was linked to disease severity (WHO functional class, p = 0.017) and independently predicted haemodynamic impairment specifically in CTEPH (p < 0.016). cteph 157-162 fibrinogen beta chain Homo sapiens 13-23 24747797-11 2014 The P/Cr levels at birth were significantly inversely correlated with the antenatal lowest antithrombin activity and fibrinogen levels among the 28 women with PE. Chromium 6-8 fibrinogen beta chain Homo sapiens 117-127 24572496-4 2014 We have also investigated the adsorption of bovine serum albumin (BSA), lysozyme or fibrinogen on a LA-co-MEO2MA surface in real time by use of QCM-D and surface plasmon resonance (SPR). la-co-meo2ma 100-112 fibrinogen beta chain Homo sapiens 84-94 24203353-1 2014 We aimed to investigate the association of aspirin and/or clopidogrel low response with -455G/A polymorphism of beta-fibrinogen in patients with acute coronary syndrome (ACS). Aspirin 43-50 fibrinogen beta chain Homo sapiens 112-127 24203353-1 2014 We aimed to investigate the association of aspirin and/or clopidogrel low response with -455G/A polymorphism of beta-fibrinogen in patients with acute coronary syndrome (ACS). Clopidogrel 58-69 fibrinogen beta chain Homo sapiens 112-127 24491335-0 2014 Hydroxyl density affects the interaction of fibrinogen with silica nanoparticles at physiological concentration. Hydroxyl Radical 0-8 fibrinogen beta chain Homo sapiens 44-54 24491335-0 2014 Hydroxyl density affects the interaction of fibrinogen with silica nanoparticles at physiological concentration. Silicon Dioxide 60-66 fibrinogen beta chain Homo sapiens 44-54 24491335-5 2014 In this study, the effect of silanol density on the interaction of fibrinogen at physiological concentrations with silica nanoparticle/flat surfaces has been studied. silanol 29-36 fibrinogen beta chain Homo sapiens 67-77 24491335-5 2014 In this study, the effect of silanol density on the interaction of fibrinogen at physiological concentrations with silica nanoparticle/flat surfaces has been studied. Silicon Dioxide 115-121 fibrinogen beta chain Homo sapiens 67-77 24491335-7 2014 The interaction with fibrinogen has been studied by evaluating the extent of coverage (bicinchoninic acid assay) and the irreversibility of adsorption (shift of the zeta potential). bicinchoninic acid 87-105 fibrinogen beta chain Homo sapiens 21-31 24491335-10 2014 The data reported here show that a minimal variation in the state of the silica surface modifies the adsorption behavior of fibrinogen, which appears mediated by a competition between protein/protein and protein/surface interactions. Silicon Dioxide 73-79 fibrinogen beta chain Homo sapiens 124-134 24491335-11 2014 By comparing the data obtained on nanoparticles and silicon-supported silica layers, we found that hydrophilicity increases the tendency of fibrinogen molecules to interact with the surface rather than with other molecules, thus inhibiting fibrinogen self-assembly. Silicon 52-59 fibrinogen beta chain Homo sapiens 140-150 24491335-11 2014 By comparing the data obtained on nanoparticles and silicon-supported silica layers, we found that hydrophilicity increases the tendency of fibrinogen molecules to interact with the surface rather than with other molecules, thus inhibiting fibrinogen self-assembly. Silicon 52-59 fibrinogen beta chain Homo sapiens 240-250 24491335-11 2014 By comparing the data obtained on nanoparticles and silicon-supported silica layers, we found that hydrophilicity increases the tendency of fibrinogen molecules to interact with the surface rather than with other molecules, thus inhibiting fibrinogen self-assembly. Silicon Dioxide 70-76 fibrinogen beta chain Homo sapiens 140-150 24491335-11 2014 By comparing the data obtained on nanoparticles and silicon-supported silica layers, we found that hydrophilicity increases the tendency of fibrinogen molecules to interact with the surface rather than with other molecules, thus inhibiting fibrinogen self-assembly. Silicon Dioxide 70-76 fibrinogen beta chain Homo sapiens 240-250 32261390-5 2014 Further natural proteins Gel and fibrinogen (Fib) solutions were also CXLed using vitamin B2 (riboflavin (Rib)) released from Rib-loaded polycaprolactone (PCL) nanofibers followed by UV treatment. Riboflavin 94-104 fibrinogen beta chain Homo sapiens 45-48 24679039-8 2014 The total cholesterol/HDL-c ratio (r = 0.222) and the LDL-c/HDL-c ratio (r = 0.235) showed the best correlations and the higher areas under the ROC curves (0.624 +- 0.049 and 0.624 +- 0.049) in identify higher levels of fibrinogen (p < 0.05). Cholesterol 10-21 fibrinogen beta chain Homo sapiens 220-230 24679039-9 2014 CONCLUSION: The uric acid and the total cholesterol/HDL-c and the LDL-c/HDL-c ratios showed greater ability to identify changes in the levels of hs-CRP and fibrinogen, respectively. Uric Acid 16-25 fibrinogen beta chain Homo sapiens 145-166 24679039-9 2014 CONCLUSION: The uric acid and the total cholesterol/HDL-c and the LDL-c/HDL-c ratios showed greater ability to identify changes in the levels of hs-CRP and fibrinogen, respectively. Cholesterol 40-51 fibrinogen beta chain Homo sapiens 145-166 32261390-5 2014 Further natural proteins Gel and fibrinogen (Fib) solutions were also CXLed using vitamin B2 (riboflavin (Rib)) released from Rib-loaded polycaprolactone (PCL) nanofibers followed by UV treatment. polycaprolactone 137-153 fibrinogen beta chain Homo sapiens 45-48 32261390-5 2014 Further natural proteins Gel and fibrinogen (Fib) solutions were also CXLed using vitamin B2 (riboflavin (Rib)) released from Rib-loaded polycaprolactone (PCL) nanofibers followed by UV treatment. polycaprolactone 155-158 fibrinogen beta chain Homo sapiens 45-48 25097995-2 2014 Second introduction of Urokinase Medac was effective for reduction of a fibrinogen level, as well as for increase in a blood supply of a LE tissues, what have promoted a better healing of the wounds. medac 33-38 fibrinogen beta chain Homo sapiens 72-82 24479758-3 2014 This study examined the effect of surface topography and chemistry of pristine and fibrinogen-adsorbed solvent cast (SC) and electrospun (ES) samples of poly(vinylidene fluoride-co-hexafluoropropylene) (PVDF-HFP) on platelet adhesion, activation, and aggregation. poly(vinylidene fluoride-co-hexafluoro propylene) 153-201 fibrinogen beta chain Homo sapiens 83-93 24479758-6 2014 Notably, increased adhesion of platelets was observed following fibrinogen adsorption on SC surface with considerable aggregation and serotonin release compared with ES samples, where limited aggregation and platelet adhesion was observed. Serotonin 134-143 fibrinogen beta chain Homo sapiens 64-74 24444162-0 2014 Human fibrinogen adsorption on latex particles at pH 7.4 studied by electrophoretic mobility and AFM measurements. Latex 31-36 fibrinogen beta chain Homo sapiens 6-16 24444162-1 2014 Human fibrinogen adsorption on negatively charged latex particles was investigated using the electrophoretic and the concentration depletion methods. Latex 50-55 fibrinogen beta chain Homo sapiens 6-16 24444162-7 2014 The maximum coverage of fibrinogen on latex particles determined via the concentration depletion method varied between 1.9 mg m(-2) and 3.2 mg m(-2) for 10(-3) and 0.15 M NaCl, respectively. Sodium Chloride 171-175 fibrinogen beta chain Homo sapiens 24-34 24189196-0 2014 Dual drug encapsulated thermo-sensitive fibrinogen-graft-poly (N-isopropyl acrylamide) nanogels for breast cancer therapy. poly-N-isopropylacrylamide 57-86 fibrinogen beta chain Homo sapiens 40-50 24701359-12 2014 t-RSV supplementation promotes reduction of the foot ulcer size and reduces plasma fibrinogen level in type 2 diabetic patients. Resveratrol 0-5 fibrinogen beta chain Homo sapiens 83-93 32261539-6 2014 The results show that the lowest relative protein adsorptions of antibody (anti-IgG) and fibrinogen (Fg) on the SAMs are 5.1 +- 1.6% and 7.3 +- 1.8%, respectively, determined by enzyme-linked immunosorbent assay (ELISA), where the protein adsorption on a tissue culture polystyrene (TCPS) surface was set to 100%. Polystyrenes 270-281 fibrinogen beta chain Homo sapiens 89-99 32261539-6 2014 The results show that the lowest relative protein adsorptions of antibody (anti-IgG) and fibrinogen (Fg) on the SAMs are 5.1 +- 1.6% and 7.3 +- 1.8%, respectively, determined by enzyme-linked immunosorbent assay (ELISA), where the protein adsorption on a tissue culture polystyrene (TCPS) surface was set to 100%. tcps 283-287 fibrinogen beta chain Homo sapiens 89-99 24360115-3 2014 In contrast, interaction with heme groups associated with fibrinogen, alpha2-antiplasmin and plasmin by carbon monoxide has resulted in enhanced coagulation and decreased fibrinolysis in vitro in human and other species, and in vivo in rabbits. Carbon Monoxide 104-119 fibrinogen beta chain Homo sapiens 58-68 32261321-3 2014 Compared to the pristine titanium, a highly hydrophilic layer was achieved after the immobilization, and the resulting heparin-PEG layer can significantly prevent human plasma fibrinogen adsorption. Titanium 25-33 fibrinogen beta chain Homo sapiens 176-186 32261321-3 2014 Compared to the pristine titanium, a highly hydrophilic layer was achieved after the immobilization, and the resulting heparin-PEG layer can significantly prevent human plasma fibrinogen adsorption. Heparin 119-126 fibrinogen beta chain Homo sapiens 176-186 32261321-3 2014 Compared to the pristine titanium, a highly hydrophilic layer was achieved after the immobilization, and the resulting heparin-PEG layer can significantly prevent human plasma fibrinogen adsorption. Polyethylene Glycols 127-130 fibrinogen beta chain Homo sapiens 176-186 24189196-1 2014 5-FU/Megestrol acetate loaded fibrinogen-graft-PNIPAAm Nanogels (5-FU/Meg-fib-graft-PNIPAAm NGs) were prepared for thermo responsive drug delivery toward alpha5beta1-integrins expressing breast cancer cells in vitro (MCF-7 cells). Megestrol Acetate 5-22 fibrinogen beta chain Homo sapiens 30-40 24189196-1 2014 5-FU/Megestrol acetate loaded fibrinogen-graft-PNIPAAm Nanogels (5-FU/Meg-fib-graft-PNIPAAm NGs) were prepared for thermo responsive drug delivery toward alpha5beta1-integrins expressing breast cancer cells in vitro (MCF-7 cells). poly-N-isopropylacrylamide 47-54 fibrinogen beta chain Homo sapiens 30-40 24189196-1 2014 5-FU/Megestrol acetate loaded fibrinogen-graft-PNIPAAm Nanogels (5-FU/Meg-fib-graft-PNIPAAm NGs) were prepared for thermo responsive drug delivery toward alpha5beta1-integrins expressing breast cancer cells in vitro (MCF-7 cells). poly-N-isopropylacrylamide 84-91 fibrinogen beta chain Homo sapiens 30-40 24482809-0 2014 Fibrinogen Hangzhou: congenital dysfibrinogenemia caused by the novel missense mutation in FGG (gamma308Asn Thr). Threonine 108-111 fibrinogen beta chain Homo sapiens 0-10 24122271-7 2014 Furthermore, in multivariate analysis, increased fibrinogen levels were significantly associated with a poor outcome for CSS (HR=2.48; 95% CI=1.28-4.78; P=0.007), DFS (HR=2.00; 95% CI=1.11-3.60; P=0.021), and OS (HR=2.20; 95% CI=1.39-3.47; P<0.001). thiocysteine 121-124 fibrinogen beta chain Homo sapiens 49-59 24122271-9 2014 CONCLUSION: The pre-operative plasma fibrinogen level may represent a strong and independent unfavorable prognostic factor for CSS, DFS and OS in STS patients. thiocysteine 127-130 fibrinogen beta chain Homo sapiens 37-47 24475207-4 2014 We have applied a powerful and novel well-tempered ensemble parallel tempering (PT-WTE) technique along with conventional molecular dynamics (MD) simulation to investigate the molecular-level consequences of selective methionine oxidation of fibrinogen. Methionine 218-228 fibrinogen beta chain Homo sapiens 242-252 24337469-10 2014 Fe(3+) and/or its hydrolytic species interact with fibrinogen and/or fibrin changing their morphology and properties. ferric sulfate 0-6 fibrinogen beta chain Homo sapiens 51-61 24205990-5 2014 Polyphenols also target various additional platelet activation pathways (e.g. by blocking platelet-ADP, collagen receptors); thus alleviating fibrinogen binding to platelet surface (GPIIb-IIIa) receptors, reducing further platelet recruitment for aggregation and inhibiting platelet degranulation. Polyphenols 0-11 fibrinogen beta chain Homo sapiens 142-152 24418385-7 2014 Fibrinogen decreased progressively with alcohol intake, from -2.2% (-3.1 to -1.3%) in MNB to -5.8% (-9.4 to -2.0%) in HB. Alcohols 40-47 fibrinogen beta chain Homo sapiens 0-10 24418385-9 2014 CONCLUSIONS: Moderate alcohol intake is associated with improved HDL-cholesterol, fibrinogen and markers of glucose metabolism, which is consistent with the reduced CHD risk of moderate drinkers in many studies. Alcohols 22-29 fibrinogen beta chain Homo sapiens 82-92 24211510-5 2014 The primary outcome measure was adenosine diphosphate (ADP)-stimulated platelet fibrinogen binding. Adenosine Diphosphate 32-53 fibrinogen beta chain Homo sapiens 80-90 24211510-5 2014 The primary outcome measure was adenosine diphosphate (ADP)-stimulated platelet fibrinogen binding. Adenosine Diphosphate 55-58 fibrinogen beta chain Homo sapiens 80-90 24211510-7 2014 RESULTS: The ADP-stimulated platelet fibrinogen binding, P-selectin expression, and platelet aggregation were lower on treatment with clopidogrel compared with baseline (p < 0.0001), but returned to baseline levels by 7 days after discontinuation. Adenosine Diphosphate 13-16 fibrinogen beta chain Homo sapiens 37-47 24211510-7 2014 RESULTS: The ADP-stimulated platelet fibrinogen binding, P-selectin expression, and platelet aggregation were lower on treatment with clopidogrel compared with baseline (p < 0.0001), but returned to baseline levels by 7 days after discontinuation. Clopidogrel 134-145 fibrinogen beta chain Homo sapiens 37-47 24292153-3 2014 Human fibrinogen is isolated from the plasma by the glycine precipitation method. Glycine 52-59 fibrinogen beta chain Homo sapiens 6-16 24292153-4 2014 Identification of N-Hcy-Lys-peptides in tryptic digests of in vivo-derived samples is facilitated by the use of N-Hcy-albumin and N-Hcy-fibrinogen synthesized in vitro from commercially available human proteins. n-hcy-lys-peptides 18-36 fibrinogen beta chain Homo sapiens 136-146 25490356-6 2014 Treatment of the thread"s surface with PHBV promoted a significant (p<0.05) decrease in the amount of absorbed proteins in the area of the vascular anastomosis in experiment: the amount of IgM decreased by 26%, that of fibrinogen by 29%, and that of D-Dimer by 281%, being on the whole indicative of bio- and haemocompatibility of the modified suture material. phbv 39-43 fibrinogen beta chain Homo sapiens 222-232 24211978-0 2014 Effects of Mn (II) on peroxynitrite nitrifying fibrinogen. mn (ii) 11-18 fibrinogen beta chain Homo sapiens 47-57 24211978-0 2014 Effects of Mn (II) on peroxynitrite nitrifying fibrinogen. Peroxynitrous Acid 22-35 fibrinogen beta chain Homo sapiens 47-57 24211978-3 2014 However, there are only a few reports relating to the activity and structural changes of nitrified fibrinogen when metal ions are present in the reaction. Metals 115-120 fibrinogen beta chain Homo sapiens 99-109 24211978-5 2014 In this study, we use UV-Vis, 3D-fluorescence, SDS-PAGE electrophoresis and Von-Clauss to detect 3-nitrotyrosine (3-NT) production and the activity changes of fibrinogen after nitration and oxidation damage caused by ONOO- in the presence of Mn (II). onoo 217-221 fibrinogen beta chain Homo sapiens 159-169 24211978-5 2014 In this study, we use UV-Vis, 3D-fluorescence, SDS-PAGE electrophoresis and Von-Clauss to detect 3-nitrotyrosine (3-NT) production and the activity changes of fibrinogen after nitration and oxidation damage caused by ONOO- in the presence of Mn (II). mn (ii) 242-249 fibrinogen beta chain Homo sapiens 159-169 24211978-6 2014 Results showed that Mn (II) can enhance the production of 3-NT in fibrinogen, promote fluorescence quenching of fibrinogen, and increase the injury to gamma and Aalpha chains of fibrinogen in the presence of peroxynitrite. mn (ii) 20-27 fibrinogen beta chain Homo sapiens 66-76 24211978-6 2014 Results showed that Mn (II) can enhance the production of 3-NT in fibrinogen, promote fluorescence quenching of fibrinogen, and increase the injury to gamma and Aalpha chains of fibrinogen in the presence of peroxynitrite. mn (ii) 20-27 fibrinogen beta chain Homo sapiens 112-122 24211978-6 2014 Results showed that Mn (II) can enhance the production of 3-NT in fibrinogen, promote fluorescence quenching of fibrinogen, and increase the injury to gamma and Aalpha chains of fibrinogen in the presence of peroxynitrite. mn (ii) 20-27 fibrinogen beta chain Homo sapiens 112-122 24211978-6 2014 Results showed that Mn (II) can enhance the production of 3-NT in fibrinogen, promote fluorescence quenching of fibrinogen, and increase the injury to gamma and Aalpha chains of fibrinogen in the presence of peroxynitrite. 3-nitrotyrosine 58-62 fibrinogen beta chain Homo sapiens 66-76 24211978-7 2014 Consequently, Mn (II) promotes concentration dependent fibrinogen nitrification damage and significantly reduces the biological activity of nitrified fibrinogen. mn (ii) 14-21 fibrinogen beta chain Homo sapiens 55-65 24211978-7 2014 Consequently, Mn (II) promotes concentration dependent fibrinogen nitrification damage and significantly reduces the biological activity of nitrified fibrinogen. mn (ii) 14-21 fibrinogen beta chain Homo sapiens 150-160 23945059-7 2014 Similar patterns were shown in experiments of ADP-induced platelet adhesion to fibrinogen immobilized at 200 mug/well. Adenosine Diphosphate 46-49 fibrinogen beta chain Homo sapiens 79-89 24898335-9 2014 Fibrinogen concentration was significantly higher in women than in men among patients treated with 100 mg ASA (p<0.05), but not in the other groups. Aspirin 106-109 fibrinogen beta chain Homo sapiens 0-10 24898335-10 2014 CONCLUSIONS: Significantly higher fibrinogen concentration found in aspirin treated women than men may play a role in higher ADP induced platelet aggregation. Aspirin 68-75 fibrinogen beta chain Homo sapiens 34-44 24898335-10 2014 CONCLUSIONS: Significantly higher fibrinogen concentration found in aspirin treated women than men may play a role in higher ADP induced platelet aggregation. Adenosine Diphosphate 125-128 fibrinogen beta chain Homo sapiens 34-44 24292153-6 2014 N-Hcy-Lys562, N-Hcy-Lys344, and N-Hcy-Lys385 were identified in human fibrinogen from patients with cystathionine beta-synthase deficiency. n-hcy 0-5 fibrinogen beta chain Homo sapiens 70-80 24292153-6 2014 N-Hcy-Lys562, N-Hcy-Lys344, and N-Hcy-Lys385 were identified in human fibrinogen from patients with cystathionine beta-synthase deficiency. Nitrogen 0-1 fibrinogen beta chain Homo sapiens 70-80 24292153-6 2014 N-Hcy-Lys562, N-Hcy-Lys344, and N-Hcy-Lys385 were identified in human fibrinogen from patients with cystathionine beta-synthase deficiency. Homocysteine 2-5 fibrinogen beta chain Homo sapiens 70-80 24292153-6 2014 N-Hcy-Lys562, N-Hcy-Lys344, and N-Hcy-Lys385 were identified in human fibrinogen from patients with cystathionine beta-synthase deficiency. n-hcy 14-19 fibrinogen beta chain Homo sapiens 70-80 24095988-5 2014 For ZnO Nps, a strong interaction was observed, which induced a decrease in the thermal stability of both fibrinogen and albumin at a low temperature, interfering with the clotting activity of fibrinogen. Zinc Oxide 4-7 fibrinogen beta chain Homo sapiens 106-116 24909805-8 2014 CONCLUSIONS: High plasma fibrinogen and low plasminogen are associated with poor survival in CTEPH patients without modern therapy. cteph 93-98 fibrinogen beta chain Homo sapiens 25-35 25016696-9 2014 We found a moderate correlation between fibrinogen-AOPP and microalbumin-AOPP levels only in the kinetic method (r = 0.644 and 0.520 for citrate-anticoagulated; r = 0.581 and 0.490 for EDTA-anticoagulated, p = 0.0001). Edetic Acid 185-189 fibrinogen beta chain Homo sapiens 40-50 24095988-5 2014 For ZnO Nps, a strong interaction was observed, which induced a decrease in the thermal stability of both fibrinogen and albumin at a low temperature, interfering with the clotting activity of fibrinogen. Zinc Oxide 4-7 fibrinogen beta chain Homo sapiens 193-203 24444156-5 2014 Adsorption kinetics of fibrinogen at hydrophilic and hydrophobic (polymer modified) substrates determined by various techniques is described. Polymers 66-73 fibrinogen beta chain Homo sapiens 23-33 25025547-11 2014 The most effective surface for preventing fibrinogen adsorption was the polymer brush surface with phosphorylcholine (PC) groups, that is, poly(2-methacryloyloxyethyl phosphorylcholine) brush. Phosphorylcholine 99-116 fibrinogen beta chain Homo sapiens 42-52 25025547-11 2014 The most effective surface for preventing fibrinogen adsorption was the polymer brush surface with phosphorylcholine (PC) groups, that is, poly(2-methacryloyloxyethyl phosphorylcholine) brush. Polymers 72-79 fibrinogen beta chain Homo sapiens 42-52 25025547-11 2014 The most effective surface for preventing fibrinogen adsorption was the polymer brush surface with phosphorylcholine (PC) groups, that is, poly(2-methacryloyloxyethyl phosphorylcholine) brush. Phosphorylcholine 118-120 fibrinogen beta chain Homo sapiens 42-52 25025547-11 2014 The most effective surface for preventing fibrinogen adsorption was the polymer brush surface with phosphorylcholine (PC) groups, that is, poly(2-methacryloyloxyethyl phosphorylcholine) brush. poly(2-methacryloyloxyethyl-phosphorylcholine) 139-185 fibrinogen beta chain Homo sapiens 42-52 25072636-5 2014 The lowest nonspecific adsorption of the model proteins, anti-IgG and fibrinogen (Fg), on the self-assembling monolayers (SAMs) surface of poly(E)-K was only 3.3 +- 1.8 and 4.4 +- 1.6%, respectively, when protein adsorption on tissue culture polystyrene surface was set as 100%. SAMS Peptide 122-126 fibrinogen beta chain Homo sapiens 70-80 25072636-5 2014 The lowest nonspecific adsorption of the model proteins, anti-IgG and fibrinogen (Fg), on the self-assembling monolayers (SAMs) surface of poly(E)-K was only 3.3 +- 1.8 and 4.4 +- 1.6%, respectively, when protein adsorption on tissue culture polystyrene surface was set as 100%. SAMS Peptide 122-126 fibrinogen beta chain Homo sapiens 82-84 25072636-5 2014 The lowest nonspecific adsorption of the model proteins, anti-IgG and fibrinogen (Fg), on the self-assembling monolayers (SAMs) surface of poly(E)-K was only 3.3 +- 1.8 and 4.4 +- 1.6%, respectively, when protein adsorption on tissue culture polystyrene surface was set as 100%. poly(e)-k 139-148 fibrinogen beta chain Homo sapiens 70-80 25072636-5 2014 The lowest nonspecific adsorption of the model proteins, anti-IgG and fibrinogen (Fg), on the self-assembling monolayers (SAMs) surface of poly(E)-K was only 3.3 +- 1.8 and 4.4 +- 1.6%, respectively, when protein adsorption on tissue culture polystyrene surface was set as 100%. poly(e)-k 139-148 fibrinogen beta chain Homo sapiens 82-84 25072636-5 2014 The lowest nonspecific adsorption of the model proteins, anti-IgG and fibrinogen (Fg), on the self-assembling monolayers (SAMs) surface of poly(E)-K was only 3.3 +- 1.8 and 4.4 +- 1.6%, respectively, when protein adsorption on tissue culture polystyrene surface was set as 100%. Polystyrenes 242-253 fibrinogen beta chain Homo sapiens 82-84 24351527-9 2014 RESULTS: In vitro studies revealed increased fibrinogen reversed the effects of heparin as measured by TEG. Heparin 80-87 fibrinogen beta chain Homo sapiens 45-55 24351527-13 2014 Moreover, there was a moderate inverse correlation between fibrinogen level and the effect of heparin (RF), which was significant on study days 1 and 3, implicating hyperfibrinogenemia in heparin resistance. Heparin 94-101 fibrinogen beta chain Homo sapiens 59-69 24351527-13 2014 Moreover, there was a moderate inverse correlation between fibrinogen level and the effect of heparin (RF), which was significant on study days 1 and 3, implicating hyperfibrinogenemia in heparin resistance. Heparin 188-195 fibrinogen beta chain Homo sapiens 59-69 24351527-15 2014 The preclinical and clinical relationships between fibrinogen levels and hypercoagulability implicate hyperfibrinogenemia as a potential factor in heparin resistance. Heparin 147-154 fibrinogen beta chain Homo sapiens 51-61 24210681-4 2014 METHODS: The fibrinogen gamma-chain expression vectors coding gamma375W and gamma375G were altered by oligonucleotide-directed mutagenesis and transfected into Chinese hamster ovary (CHO) cells. Oligonucleotides 102-117 fibrinogen beta chain Homo sapiens 13-23 25509887-11 2014 CONCLUSION: The regression analysis has shown that prior MI, DM, smoking, creatinine and fibrinogen levels are factors associated with the development of MFA in the examined groups. mfa 154-157 fibrinogen beta chain Homo sapiens 89-99 24349096-4 2013 They also have reduced capacity to be "primed" to bind fibrinogen by pretreatment with eptifibatide. Eptifibatide 87-99 fibrinogen beta chain Homo sapiens 55-65 24245771-3 2013 Following exposure to albumin (or fibrinogen) under near neutral pH conditions, planar gold electrodes showed an immediate reduction in Faradaic peak current and increase in peak splitting for potassium ferricyanide. potassium ferricyanide 193-215 fibrinogen beta chain Homo sapiens 34-44 23959335-0 2013 Gallium nitrate induces fibrinogen flocculation: an explanation for its hemostatic effect? gallium nitrate 0-15 fibrinogen beta chain Homo sapiens 24-34 23959335-4 2013 We measured functional fibrinogen in whole blood after addition of gallium nitrate and nitric acid. gallium nitrate 67-82 fibrinogen beta chain Homo sapiens 23-33 23959335-5 2013 We found that gallium nitrate induces fibrinogen precipitation in whole blood to a significantly higher degree than solutions of nitric acid alone. gallium nitrate 14-29 fibrinogen beta chain Homo sapiens 38-48 23504818-9 2013 Stress interacted with caffeine and sex to alter cortisol, fibrinogen and systolic BP but not CRP levels. Caffeine 23-31 fibrinogen beta chain Homo sapiens 59-69 24266353-4 2013 Sublethal doses of manuka honey inhibited bacterial adhesion to the fibronectin, fibrinogen and collagen. manuka honey 19-31 fibrinogen beta chain Homo sapiens 81-91 24029856-5 2013 RESULTS: Colloid dilution led to a significant reduction of fibrinogen polymerization, especially with HES. Helium 103-106 fibrinogen beta chain Homo sapiens 60-70 24176510-10 2013 This finding leads to the assumption that only FG and FN attach to the TiO2 sensor surface under the given experimental conditions. titanium dioxide 71-75 fibrinogen beta chain Homo sapiens 47-49 24288588-0 2013 Nitric oxide-flux dependent bacterial adhesion and viability at fibrinogen-coated surfaces. Nitric Oxide 0-12 fibrinogen beta chain Homo sapiens 64-74 23375935-0 2013 Fibrinogen and inflammatory cytokines in spontaneous sputum of sulfur-mustard-exposed civilians--Sardasht-Iran Cohort Study. Mustard Gas 63-77 fibrinogen beta chain Homo sapiens 0-10 23911741-4 2013 This study proposed to investigate the application of these two polymers, based on their potential for globular protein adsorption (BSA and fibrinogen). Polymers 64-72 fibrinogen beta chain Homo sapiens 140-150 23375935-2 2013 In this preliminary study, the levels of IL-1alpha and beta, TNF, IL-1Ra, IL-6 and fibrinogen in the spontaneous sputum of SM-exposed individuals were examined 20 years after exposure and the correlation with pulmonary function was tested. Mustard Gas 123-125 fibrinogen beta chain Homo sapiens 83-93 32481872-3 2013 Electrophoretic profiling confirmed that the electrospun FBG resembled the native protein structure, and fluorescent tracing of FITC-labeled FBG showed that electrospun fibers withstood immersion in physiological solutions reasonably well for several days. Fluorescein-5-isothiocyanate 128-132 fibrinogen beta chain Homo sapiens 141-144 23554300-0 2013 Nitric oxide releasing material adsorbs more fibrinogen. Nitric Oxide 0-12 fibrinogen beta chain Homo sapiens 45-55 24108112-12 2013 In patients with CD, Ks and lysis time were independently predicted by fibrinogen and C-reactive protein. Potassium 21-23 fibrinogen beta chain Homo sapiens 71-81 23953632-0 2013 Testosterone and acute stress are associated with fibrinogen and von Willebrand factor in African men: the SABPA study. Testosterone 0-12 fibrinogen beta chain Homo sapiens 50-60 24205388-5 2013 Heparin-binding domains within Fg (residues 15-66 of the beta chain, Fg beta15-66) and FN (FNI1-5, but not FNIII12-14) were involved in binding to CXCL10 and CXCL11 but not CXCL9. Heparin 0-7 fibrinogen beta chain Homo sapiens 31-33 24235886-3 2013 We exposed fibrinogen molecules to three different modification reagents-malondialdehyde, sodium hypochlorite, and peroxynitrite-that are presented to various degrees in different stages of oxidative stress. Malondialdehyde 73-88 fibrinogen beta chain Homo sapiens 11-21 24235886-3 2013 We exposed fibrinogen molecules to three different modification reagents-malondialdehyde, sodium hypochlorite, and peroxynitrite-that are presented to various degrees in different stages of oxidative stress. Sodium Hypochlorite 90-109 fibrinogen beta chain Homo sapiens 11-21 24235886-3 2013 We exposed fibrinogen molecules to three different modification reagents-malondialdehyde, sodium hypochlorite, and peroxynitrite-that are presented to various degrees in different stages of oxidative stress. Peroxynitrous Acid 115-128 fibrinogen beta chain Homo sapiens 11-21 24235886-5 2013 The fastest modification of fibrinogen was caused by hypochlorite. Hypochlorous Acid 53-65 fibrinogen beta chain Homo sapiens 28-38 24235886-7 2013 We found that platelet dynamic adhesion was significantly lower on fibrinogen modified with malondialdehyde and significantly higher on fibrinogen modified either with hypochlorite or peroxynitrite reflecting different prothrombotic/antithrombotic properties of oxidatively modified fibrinogens. Malondialdehyde 92-107 fibrinogen beta chain Homo sapiens 67-77 24235886-7 2013 We found that platelet dynamic adhesion was significantly lower on fibrinogen modified with malondialdehyde and significantly higher on fibrinogen modified either with hypochlorite or peroxynitrite reflecting different prothrombotic/antithrombotic properties of oxidatively modified fibrinogens. Hypochlorous Acid 168-180 fibrinogen beta chain Homo sapiens 136-146 24235886-7 2013 We found that platelet dynamic adhesion was significantly lower on fibrinogen modified with malondialdehyde and significantly higher on fibrinogen modified either with hypochlorite or peroxynitrite reflecting different prothrombotic/antithrombotic properties of oxidatively modified fibrinogens. Peroxynitrous Acid 184-197 fibrinogen beta chain Homo sapiens 136-146 24235886-8 2013 It seems that, in the complex reactions ongoing in living organisms at conditions of oxidation stress, hypochlorite modifies proteins (e.g., fibrinogen) faster and more preferentially than malondialdehyde. Hypochlorous Acid 103-115 fibrinogen beta chain Homo sapiens 141-151 24235886-9 2013 It suggests that the prothrombotic effects of prior fibrinogen modifications may outweigh the antithrombotic effect of malondialdehyde-modified fibrinogen in real living systems. Malondialdehyde 119-134 fibrinogen beta chain Homo sapiens 144-154 23990470-0 2013 Zn2+ mediates high affinity binding of heparin to the alphaC domain of fibrinogen. Zinc 0-4 fibrinogen beta chain Homo sapiens 71-81 23990470-0 2013 Zn2+ mediates high affinity binding of heparin to the alphaC domain of fibrinogen. Heparin 39-46 fibrinogen beta chain Homo sapiens 71-81 23990470-3 2013 Previous studies have shown that heparin binds the E domain of fibrinogen. Heparin 33-40 fibrinogen beta chain Homo sapiens 63-73 23990470-5 2013 Zn(2+) promotes heparin binding to fibrinogen, as determined by chromatography, fluorescence, and surface plasmon resonance. Zinc 0-6 fibrinogen beta chain Homo sapiens 35-45 23990470-5 2013 Zn(2+) promotes heparin binding to fibrinogen, as determined by chromatography, fluorescence, and surface plasmon resonance. Heparin 16-23 fibrinogen beta chain Homo sapiens 35-45 23990470-6 2013 Compared with intact fibrinogen, there is reduced heparin binding to fragment X, a clottable plasmin degradation product of fibrinogen. Heparin 50-57 fibrinogen beta chain Homo sapiens 21-31 23990470-6 2013 Compared with intact fibrinogen, there is reduced heparin binding to fragment X, a clottable plasmin degradation product of fibrinogen. Heparin 50-57 fibrinogen beta chain Homo sapiens 124-134 23990470-7 2013 A monoclonal antibody directed against a portion of the fibrinogen alphaC domain removed by plasmin attenuates binding of heparin to fibrinogen and a peptide analog of this region binds heparin in a Zn(2+)-dependent fashion. Heparin 122-129 fibrinogen beta chain Homo sapiens 56-66 23990470-7 2013 A monoclonal antibody directed against a portion of the fibrinogen alphaC domain removed by plasmin attenuates binding of heparin to fibrinogen and a peptide analog of this region binds heparin in a Zn(2+)-dependent fashion. Heparin 122-129 fibrinogen beta chain Homo sapiens 133-143 23990470-7 2013 A monoclonal antibody directed against a portion of the fibrinogen alphaC domain removed by plasmin attenuates binding of heparin to fibrinogen and a peptide analog of this region binds heparin in a Zn(2+)-dependent fashion. Heparin 186-193 fibrinogen beta chain Homo sapiens 56-66 23990470-7 2013 A monoclonal antibody directed against a portion of the fibrinogen alphaC domain removed by plasmin attenuates binding of heparin to fibrinogen and a peptide analog of this region binds heparin in a Zn(2+)-dependent fashion. Zinc 199-201 fibrinogen beta chain Homo sapiens 56-66 23990470-8 2013 These results indicate that the alphaC domain of fibrinogen harbors a Zn(2+)-dependent heparin binding site. Zinc 70-76 fibrinogen beta chain Homo sapiens 49-59 23990470-8 2013 These results indicate that the alphaC domain of fibrinogen harbors a Zn(2+)-dependent heparin binding site. Heparin 87-94 fibrinogen beta chain Homo sapiens 49-59 23990470-9 2013 As a consequence, heparin-catalyzed inhibition of factor Xa by antithrombin is compromised by fibrinogen to a greater extent when Zn(2+) is present. Heparin 18-25 fibrinogen beta chain Homo sapiens 94-104 23990470-9 2013 As a consequence, heparin-catalyzed inhibition of factor Xa by antithrombin is compromised by fibrinogen to a greater extent when Zn(2+) is present. Zinc 130-132 fibrinogen beta chain Homo sapiens 94-104 23990470-10 2013 These results reveal the mechanism by which Zn(2+) augments the capacity of fibrinogen to impair the anticoagulant activity of heparin. Zinc 44-50 fibrinogen beta chain Homo sapiens 76-86 23990470-10 2013 These results reveal the mechanism by which Zn(2+) augments the capacity of fibrinogen to impair the anticoagulant activity of heparin. Heparin 127-134 fibrinogen beta chain Homo sapiens 76-86 23985811-8 2013 Within dizygotic twin pairs only, associations between growth and triglycerides and fibrinogen (eg, fibrinogen: b = 0.07 ln mg/dL per change in z score, P = 0.31 in monozygotic twins; b = 0.79, P = 0.01 in dizygotic twins from 0 to 1 mo) were identified. Triglycerides 66-79 fibrinogen beta chain Homo sapiens 84-94 23797785-7 2013 We investigated TGM-2 crosslinking of several biogenic amines (serotonin, histamine, dopamine and noradrenaline) to fibrinogen. Amines 55-61 fibrinogen beta chain Homo sapiens 116-126 23797785-7 2013 We investigated TGM-2 crosslinking of several biogenic amines (serotonin, histamine, dopamine and noradrenaline) to fibrinogen. Serotonin 63-72 fibrinogen beta chain Homo sapiens 116-126 23797785-7 2013 We investigated TGM-2 crosslinking of several biogenic amines (serotonin, histamine, dopamine and noradrenaline) to fibrinogen. Histamine 74-83 fibrinogen beta chain Homo sapiens 116-126 23797785-7 2013 We investigated TGM-2 crosslinking of several biogenic amines (serotonin, histamine, dopamine and noradrenaline) to fibrinogen. Dopamine 85-93 fibrinogen beta chain Homo sapiens 116-126 23797785-7 2013 We investigated TGM-2 crosslinking of several biogenic amines (serotonin, histamine, dopamine and noradrenaline) to fibrinogen. Norepinephrine 98-111 fibrinogen beta chain Homo sapiens 116-126 23797785-9 2013 Histamine caused a concentration-dependent inhibition of fibrinogen cross-linking by TGM-2. Histamine 0-9 fibrinogen beta chain Homo sapiens 57-67 23797785-13 2013 In summary, the histaminylation of fibrinogen by TGM-2 could play a role in modifying inflammation by sequestering free histamine and by inhibiting TGM-2 crosslinking of fibrinogen. Histamine 120-129 fibrinogen beta chain Homo sapiens 35-45 23649979-7 2013 We found that RASOV was sensitive to changes of fibrinogen content (0.5-6 mg/mL), as well as to the amount of fibrinogen converted to fibrin during clot formation. rasov 14-19 fibrinogen beta chain Homo sapiens 48-58 23649979-7 2013 We found that RASOV was sensitive to changes of fibrinogen content (0.5-6 mg/mL), as well as to the amount of fibrinogen converted to fibrin during clot formation. rasov 14-19 fibrinogen beta chain Homo sapiens 110-120 24237152-0 2013 Ozone-induced oxidative modification of fibrinogen molecules. Ozone 0-5 fibrinogen beta chain Homo sapiens 40-50 24237152-1 2013 Ozone-induced oxidation of fibrinogen has been investigated. Ozone 0-5 fibrinogen beta chain Homo sapiens 27-37 23864430-0 2013 Functional binding analysis of human fibrinogen as an iron- and heme-binding protein. Iron 54-58 fibrinogen beta chain Homo sapiens 37-47 23864430-1 2013 Human fibrinogen is a metal ion-binding protein, but its mechanism of binding with iron and heme has not been elucidated in detail. Metals 22-27 fibrinogen beta chain Homo sapiens 6-16 23864430-1 2013 Human fibrinogen is a metal ion-binding protein, but its mechanism of binding with iron and heme has not been elucidated in detail. Iron 83-87 fibrinogen beta chain Homo sapiens 6-16 23864430-1 2013 Human fibrinogen is a metal ion-binding protein, but its mechanism of binding with iron and heme has not been elucidated in detail. Heme 92-96 fibrinogen beta chain Homo sapiens 6-16 23864430-2 2013 In this study, human fibrinogen was immobilized on CNBr-activated Sepharose 4B beads. Sepharose 66-78 fibrinogen beta chain Homo sapiens 21-31 23864430-3 2013 The fibrinogen beads bound hemin (iron-protoporphyrin IX: PPIX) as well as iron ion released from ferrous ammonium sulfate (FAS) more efficiently than Sepharose 4B beads alone. Hemin 27-32 fibrinogen beta chain Homo sapiens 4-14 23864430-3 2013 The fibrinogen beads bound hemin (iron-protoporphyrin IX: PPIX) as well as iron ion released from ferrous ammonium sulfate (FAS) more efficiently than Sepharose 4B beads alone. iron protoporphyrin IX 34-56 fibrinogen beta chain Homo sapiens 4-14 23864430-3 2013 The fibrinogen beads bound hemin (iron-protoporphyrin IX: PPIX) as well as iron ion released from ferrous ammonium sulfate (FAS) more efficiently than Sepharose 4B beads alone. protoporphyrin IX 58-62 fibrinogen beta chain Homo sapiens 4-14 23864430-3 2013 The fibrinogen beads bound hemin (iron-protoporphyrin IX: PPIX) as well as iron ion released from ferrous ammonium sulfate (FAS) more efficiently than Sepharose 4B beads alone. Iron 34-38 fibrinogen beta chain Homo sapiens 4-14 23864430-3 2013 The fibrinogen beads bound hemin (iron-protoporphyrin IX: PPIX) as well as iron ion released from ferrous ammonium sulfate (FAS) more efficiently than Sepharose 4B beads alone. ammonium ferrous sulfate 98-122 fibrinogen beta chain Homo sapiens 4-14 23864430-3 2013 The fibrinogen beads bound hemin (iron-protoporphyrin IX: PPIX) as well as iron ion released from ferrous ammonium sulfate (FAS) more efficiently than Sepharose 4B beads alone. ammonium ferrous sulfate 124-127 fibrinogen beta chain Homo sapiens 4-14 23864430-3 2013 The fibrinogen beads bound hemin (iron-protoporphyrin IX: PPIX) as well as iron ion released from ferrous ammonium sulfate (FAS) more efficiently than Sepharose 4B beads alone. Sepharose 151-163 fibrinogen beta chain Homo sapiens 4-14 23864430-5 2013 The affinity of fibrinogen binding to hemin, Sn-PPIX, Zn-PPIX and metal-free PPIX followed the order Sn-PPIX metal-free PPIX < hemin < Zn-PPIX; PPIX bound more non-specifically to control beads. tin protoporphyrin IX 45-52 fibrinogen beta chain Homo sapiens 16-26 23864430-5 2013 The affinity of fibrinogen binding to hemin, Sn-PPIX, Zn-PPIX and metal-free PPIX followed the order Sn-PPIX metal-free PPIX < hemin < Zn-PPIX; PPIX bound more non-specifically to control beads. zinc protoporphyrin 54-61 fibrinogen beta chain Homo sapiens 16-26 23864430-5 2013 The affinity of fibrinogen binding to hemin, Sn-PPIX, Zn-PPIX and metal-free PPIX followed the order Sn-PPIX metal-free PPIX < hemin < Zn-PPIX; PPIX bound more non-specifically to control beads. Metals 66-71 fibrinogen beta chain Homo sapiens 16-26 23864430-5 2013 The affinity of fibrinogen binding to hemin, Sn-PPIX, Zn-PPIX and metal-free PPIX followed the order Sn-PPIX metal-free PPIX < hemin < Zn-PPIX; PPIX bound more non-specifically to control beads. protoporphyrin IX 48-52 fibrinogen beta chain Homo sapiens 16-26 23864430-5 2013 The affinity of fibrinogen binding to hemin, Sn-PPIX, Zn-PPIX and metal-free PPIX followed the order Sn-PPIX metal-free PPIX < hemin < Zn-PPIX; PPIX bound more non-specifically to control beads. tin protoporphyrin IX 101-108 fibrinogen beta chain Homo sapiens 16-26 23864430-5 2013 The affinity of fibrinogen binding to hemin, Sn-PPIX, Zn-PPIX and metal-free PPIX followed the order Sn-PPIX metal-free PPIX < hemin < Zn-PPIX; PPIX bound more non-specifically to control beads. Metals 109-114 fibrinogen beta chain Homo sapiens 16-26 23864430-5 2013 The affinity of fibrinogen binding to hemin, Sn-PPIX, Zn-PPIX and metal-free PPIX followed the order Sn-PPIX metal-free PPIX < hemin < Zn-PPIX; PPIX bound more non-specifically to control beads. protoporphyrin IX 57-61 fibrinogen beta chain Homo sapiens 16-26 23864430-5 2013 The affinity of fibrinogen binding to hemin, Sn-PPIX, Zn-PPIX and metal-free PPIX followed the order Sn-PPIX metal-free PPIX < hemin < Zn-PPIX; PPIX bound more non-specifically to control beads. Hemin 38-43 fibrinogen beta chain Homo sapiens 16-26 23864430-5 2013 The affinity of fibrinogen binding to hemin, Sn-PPIX, Zn-PPIX and metal-free PPIX followed the order Sn-PPIX metal-free PPIX < hemin < Zn-PPIX; PPIX bound more non-specifically to control beads. zinc protoporphyrin 141-148 fibrinogen beta chain Homo sapiens 16-26 23864430-5 2013 The affinity of fibrinogen binding to hemin, Sn-PPIX, Zn-PPIX and metal-free PPIX followed the order Sn-PPIX metal-free PPIX < hemin < Zn-PPIX; PPIX bound more non-specifically to control beads. protoporphyrin IX 57-61 fibrinogen beta chain Homo sapiens 16-26 23864430-6 2013 FAS significantly enhanced the binding of hemin to fibrinogen beads. ammonium ferrous sulfate 0-3 fibrinogen beta chain Homo sapiens 51-61 23864430-7 2013 These results suggest that human fibrinogen directly recognizes iron ion, the PPIX ring and metal ions complexed with the PPIX ring, and that the binding of hemin is augmented by iron ions. Iron 64-68 fibrinogen beta chain Homo sapiens 33-43 23864430-7 2013 These results suggest that human fibrinogen directly recognizes iron ion, the PPIX ring and metal ions complexed with the PPIX ring, and that the binding of hemin is augmented by iron ions. protoporphyrin IX 78-82 fibrinogen beta chain Homo sapiens 33-43 23864430-7 2013 These results suggest that human fibrinogen directly recognizes iron ion, the PPIX ring and metal ions complexed with the PPIX ring, and that the binding of hemin is augmented by iron ions. Metals 92-97 fibrinogen beta chain Homo sapiens 33-43 23864430-7 2013 These results suggest that human fibrinogen directly recognizes iron ion, the PPIX ring and metal ions complexed with the PPIX ring, and that the binding of hemin is augmented by iron ions. protoporphyrin IX 122-126 fibrinogen beta chain Homo sapiens 33-43 23864430-7 2013 These results suggest that human fibrinogen directly recognizes iron ion, the PPIX ring and metal ions complexed with the PPIX ring, and that the binding of hemin is augmented by iron ions. Iron 179-183 fibrinogen beta chain Homo sapiens 33-43 23245725-11 2013 Incubation with fibrinogen had no effect on EXTEM maximum clot firmness but improved FIBTEM maximum clot firmness in saline (P <0.001) and albumin (P <0.05), but not gelatine and hydroxyethyl starch). Sodium Chloride 117-123 fibrinogen beta chain Homo sapiens 16-26 23245725-11 2013 Incubation with fibrinogen had no effect on EXTEM maximum clot firmness but improved FIBTEM maximum clot firmness in saline (P <0.001) and albumin (P <0.05), but not gelatine and hydroxyethyl starch). Hydroxyethyl starch 185-204 fibrinogen beta chain Homo sapiens 16-26 23245725-16 2013 The combination of fibrinogen and factor XIII is highly effective in raising FIBTEM maximum clot firmness after dilution with albumin, gelatine and saline back to normal values, but is ineffective in 130/0.4 hydroxyethyl starch. Sodium Chloride 148-154 fibrinogen beta chain Homo sapiens 19-29 23859812-4 2013 In this work, we study the rheological properties of a hydroxyapatite suspension system with additions of the proteins bovine serum albumin (BSA), lysozyme (LSZ) and fibrinogen (FIB). Durapatite 55-69 fibrinogen beta chain Homo sapiens 178-181 23859812-9 2013 Due to the weak interaction of the protein molecules with the hydroxyapatite particles of the suspension, we find that BSA forms the most stable interfacial films, followed by FIB. Durapatite 62-76 fibrinogen beta chain Homo sapiens 176-179 24144760-8 2013 CONCLUSION: Sequential treatment with alprostadil and beraprost sodium can improve the glomerular filtration rate and decrease urine albumin excretion rate, serum creatinine increase rate, and lower blood fibrinogen and D-dimer levels, thus delaying the progression of chronic renal failure caused by chronic glomerulonephritis. Alprostadil 38-49 fibrinogen beta chain Homo sapiens 205-215 24144760-8 2013 CONCLUSION: Sequential treatment with alprostadil and beraprost sodium can improve the glomerular filtration rate and decrease urine albumin excretion rate, serum creatinine increase rate, and lower blood fibrinogen and D-dimer levels, thus delaying the progression of chronic renal failure caused by chronic glomerulonephritis. beraprost 54-70 fibrinogen beta chain Homo sapiens 205-215 24000886-6 2013 RESULTS: Prolonged thrombin time and reduced ratio between the functional and the protein concentration of fibrinogen were observed in four family members who also were characterized by significantly reduced fibrin polymerization (p < 0.001), reduced fibrin fibre diameter (p < 0.001), reduced fibrin mass-length ratio (p < 0.001) and significantly reduced t-PA-induced fibrinolysis of the fibrin clots (p < 0.001) when compared to controls. t-pa 366-370 fibrinogen beta chain Homo sapiens 107-117 23937531-1 2013 Colloid particle deposition was applied to characterize bovine and human fibrinogen (Fb) monolayers on mica produced by controlled adsorption under diffusion transport at pH 3.5. mica 103-107 fibrinogen beta chain Homo sapiens 73-83 23937531-1 2013 Colloid particle deposition was applied to characterize bovine and human fibrinogen (Fb) monolayers on mica produced by controlled adsorption under diffusion transport at pH 3.5. mica 103-107 fibrinogen beta chain Homo sapiens 85-87 23937531-4 2013 It was shown that Fb adsorbs irreversibly on mica for a broad range of ionic strength of 4 x 10(-4) to 0.15 M, NaCl. mica 45-49 fibrinogen beta chain Homo sapiens 18-20 23937531-4 2013 It was shown that Fb adsorbs irreversibly on mica for a broad range of ionic strength of 4 x 10(-4) to 0.15 M, NaCl. Sodium Chloride 111-115 fibrinogen beta chain Homo sapiens 18-20 23937531-5 2013 The overcharging of initially negative mica surface occurred for fibrinogen surface concentrations higher than 1400 mum(-2). mica 39-43 fibrinogen beta chain Homo sapiens 65-75 23937531-6 2013 The orientation of fibrinogen molecules in the monolayers was evaluated by the colloid deposition method involving negatively charged polystyrene latex microspheres, 820 nm in diameter. Polystyrenes 134-145 fibrinogen beta chain Homo sapiens 19-29 23937531-9 2013 This confirms that, at this pH, fibrinogen molecules adsorb end-on on mica assuming extended conformations with the positive charge located mostly in the end part of the alphaA chains. mica 70-74 fibrinogen beta chain Homo sapiens 32-42 23958299-3 2013 The isotopic labeling using [(13)C6] glucose combined with LC-MS were applied as tool for identification possible glycation sites in fibrinogen and for evaluation the effect of HSA on the glycation level of selected amino acids in fibrinogen. 13)c6] glucose 30-44 fibrinogen beta chain Homo sapiens 133-143 23884371-0 2013 Molecular interactions of different size AuNP-COOH nanoparticles with human fibrinogen. aunp 41-45 fibrinogen beta chain Homo sapiens 76-86 23884371-0 2013 Molecular interactions of different size AuNP-COOH nanoparticles with human fibrinogen. Carbonic Acid 46-50 fibrinogen beta chain Homo sapiens 76-86 23884371-4 2013 In this study the binding kinetics of human Fg to negatively charged 11-mercaptoundecanoic acid-functionalized gold nanoparticles (AuNPs-COOH) ranging from 5.6 to 64.5 nm were examined. 11-mercaptoundecanoic acid 69-95 fibrinogen beta chain Homo sapiens 44-46 23884371-4 2013 In this study the binding kinetics of human Fg to negatively charged 11-mercaptoundecanoic acid-functionalized gold nanoparticles (AuNPs-COOH) ranging from 5.6 to 64.5 nm were examined. Carbonic Acid 137-141 fibrinogen beta chain Homo sapiens 44-46 23884371-6 2013 By contrast, the 5.6 nm AuNPs-COOH behaved in a cooperative manner for Fg adsorption. Carbonic Acid 30-34 fibrinogen beta chain Homo sapiens 71-73 23884371-7 2013 In the presence of excess Fg, only the 64.5 nm AuNPs-COOH showed severe aggregation, whose degree was alleviated in a dilute Fg solution. Carbonic Acid 53-57 fibrinogen beta chain Homo sapiens 26-28 23884371-7 2013 In the presence of excess Fg, only the 64.5 nm AuNPs-COOH showed severe aggregation, whose degree was alleviated in a dilute Fg solution. Carbonic Acid 53-57 fibrinogen beta chain Homo sapiens 125-127 23884371-8 2013 The Fg is adsorbed through a side-on configuration and both side-on and end-on configurations on the smaller (5.6 and 14.2 nm) and 31.5 nm AuNPs-COOH, respectively. Carbonic Acid 145-149 fibrinogen beta chain Homo sapiens 4-6 23884371-10 2013 By contrast, on the 64.5 nm AuNPs-COOH the Fg adopts the end-on configuration and loses most of the secondary structure. Carbonic Acid 34-38 fibrinogen beta chain Homo sapiens 43-45 24308225-11 2013 In Group 1 and 2, significant correlations between the ADP test and both, platelet count (r = 0.347, p < 0.001) and fibrinogen level (r = 0.364, p < 0.001) were observed. Adenosine Diphosphate 55-58 fibrinogen beta chain Homo sapiens 119-129 23817544-3 2013 Carbon monoxide has been demonstrated to markedly enhance plasmatic coagulation in vitro and in vivo via enhancement of fibrinogen"s substrate properties by binding to a fibrinogen-associated heme group(s). Carbon Monoxide 0-15 fibrinogen beta chain Homo sapiens 120-130 23817544-3 2013 Carbon monoxide has been demonstrated to markedly enhance plasmatic coagulation in vitro and in vivo via enhancement of fibrinogen"s substrate properties by binding to a fibrinogen-associated heme group(s). Carbon Monoxide 0-15 fibrinogen beta chain Homo sapiens 170-180 23817544-3 2013 Carbon monoxide has been demonstrated to markedly enhance plasmatic coagulation in vitro and in vivo via enhancement of fibrinogen"s substrate properties by binding to a fibrinogen-associated heme group(s). Heme 192-196 fibrinogen beta chain Homo sapiens 120-130 23817544-3 2013 Carbon monoxide has been demonstrated to markedly enhance plasmatic coagulation in vitro and in vivo via enhancement of fibrinogen"s substrate properties by binding to a fibrinogen-associated heme group(s). Heme 192-196 fibrinogen beta chain Homo sapiens 170-180 22564386-3 2013 METHOD: We fabricated poly(glycerol sebacate)/fibrinogen (PGS/fibrinogen) core/shell fibers with core as elastomeric PGS provides suitable mechanical properties comparable to that of native tissue and shell as fibrinogen to promote cell-biomaterial interactions. poly(glycerol-sebacate) 22-44 fibrinogen beta chain Homo sapiens 62-72 23413086-5 2013 As the FNG concentration increased, network formation increased, but porosity and water-uptake ability were slightly reduced at high FNG concentrations. Water 82-87 fibrinogen beta chain Homo sapiens 7-10 23413086-5 2013 As the FNG concentration increased, network formation increased, but porosity and water-uptake ability were slightly reduced at high FNG concentrations. Water 82-87 fibrinogen beta chain Homo sapiens 133-136 24103871-15 2013 Abnormal fibrinogen molecule (molecule weight>340 000) were found in transfected COS-7 cells by Western blot, which indicated that the mutation caused the abnormal intracellular fibrinogen molecule assembly. carbonyl sulfide 84-87 fibrinogen beta chain Homo sapiens 9-19 24103871-15 2013 Abnormal fibrinogen molecule (molecule weight>340 000) were found in transfected COS-7 cells by Western blot, which indicated that the mutation caused the abnormal intracellular fibrinogen molecule assembly. carbonyl sulfide 84-87 fibrinogen beta chain Homo sapiens 181-191 22564386-3 2013 METHOD: We fabricated poly(glycerol sebacate)/fibrinogen (PGS/fibrinogen) core/shell fibers with core as elastomeric PGS provides suitable mechanical properties comparable to that of native tissue and shell as fibrinogen to promote cell-biomaterial interactions. poly(glycerol-sebacate) 22-44 fibrinogen beta chain Homo sapiens 62-72 23875785-0 2013 Structural insights into fibrinogen dynamics using amide hydrogen/deuterium exchange mass spectrometry. Amides 51-56 fibrinogen beta chain Homo sapiens 25-35 23875785-0 2013 Structural insights into fibrinogen dynamics using amide hydrogen/deuterium exchange mass spectrometry. Hydrogen 57-65 fibrinogen beta chain Homo sapiens 25-35 23875785-0 2013 Structural insights into fibrinogen dynamics using amide hydrogen/deuterium exchange mass spectrometry. Deuterium 66-75 fibrinogen beta chain Homo sapiens 25-35 23875785-1 2013 We determined the amide hydrogen/deuterium exchange profile of native human fibrinogen under physiologic conditions. Amides 18-23 fibrinogen beta chain Homo sapiens 76-86 23875785-1 2013 We determined the amide hydrogen/deuterium exchange profile of native human fibrinogen under physiologic conditions. Hydrogen 24-32 fibrinogen beta chain Homo sapiens 76-86 23875785-1 2013 We determined the amide hydrogen/deuterium exchange profile of native human fibrinogen under physiologic conditions. Deuterium 33-42 fibrinogen beta chain Homo sapiens 76-86 23875785-3 2013 The compact central and distal globular regions of fibrinogen were well protected from deuterium exchange, with the exception of the unfolded amino-terminal segments of the Aalpha and Bbeta chains extending from the central region, and the short gamma chain "tail" extending from each distal globular region. Deuterium 87-96 fibrinogen beta chain Homo sapiens 51-61 23777276-3 2013 CBAA-PAMAM-20 and fibrinogen (Fg) could coexist in solution without forming aggregation, indicating very weak interaction force between CBAA-PAMAM-20 and fibrinogen. cbaa-pamam-20 0-13 fibrinogen beta chain Homo sapiens 154-164 23976844-0 2013 Valproic acid-associated low fibrinogen and delayed intracranial hemorrhage: case report and mini literature review. Valproic Acid 0-13 fibrinogen beta chain Homo sapiens 29-39 23721262-4 2013 We have shown that trivalent iron (FeIII) initiates a hydroxyl radical-catalyzed conversion of fibrinogen into a fibrin-like polymer (parafibrin) that is remarkably resistant to the proteolytic dissolution and thus promotes its intravascular deposition. Iron 29-33 fibrinogen beta chain Homo sapiens 95-105 23721262-4 2013 We have shown that trivalent iron (FeIII) initiates a hydroxyl radical-catalyzed conversion of fibrinogen into a fibrin-like polymer (parafibrin) that is remarkably resistant to the proteolytic dissolution and thus promotes its intravascular deposition. Hydroxyl Radical 54-70 fibrinogen beta chain Homo sapiens 95-105 23721262-6 2013 We study the effects of certain amphiphilic substances on the iron- and thrombin-induced fibrinogen polymerization visualized using scanning electron microscopy. Iron 62-66 fibrinogen beta chain Homo sapiens 89-99 23847267-5 2013 MAIN OUTCOME MEASURES: 13-year changes in alcohol use related to changes in fibrinogen. Alcohols 42-49 fibrinogen beta chain Homo sapiens 76-86 23849249-7 2013 FIB upon admission correlated strongly with Hb, BE and ISS. Beryllium 48-50 fibrinogen beta chain Homo sapiens 0-3 23849249-13 2013 Of patients with BE <-6 mmol/L upon admission, 81% had low FIB and 63% had critical FIB. Beryllium 17-19 fibrinogen beta chain Homo sapiens 62-65 23849249-13 2013 Of patients with BE <-6 mmol/L upon admission, 81% had low FIB and 63% had critical FIB. Beryllium 17-19 fibrinogen beta chain Homo sapiens 87-90 23849249-13 2013 Of patients with BE <-6 mmol/L upon admission, 81% had low FIB and 63% had critical FIB. Leu-Thr 21-23 fibrinogen beta chain Homo sapiens 62-65 23849249-13 2013 Of patients with BE <-6 mmol/L upon admission, 81% had low FIB and 63% had critical FIB. Leu-Thr 21-23 fibrinogen beta chain Homo sapiens 87-90 23560673-6 2013 Thirteen of them were novel, including seven frameshifts (fibrinogen Aalpha: p.Asp296 fs*59, p.Thr466 fs*17 and p.Lys575 fs*74; fibrinogen Bbeta: p.Gly414 fs*2 and fibrinogen gamma: p.Ser81 fs*5, p.Lys185 fs*13 and p.Asp278_279 fs*17), three splice site mutations (FGA gene c.364+1G>A; c.510+2 T>G; FGB gene c.851+1G>A), two missense substitutions (fibrinogen Bbeta: p.Gly288Ser; p.Arg445Thr) and a nonsense mutation in fibrinogen Aalpha (p.Tyr127*). asp278_279 217-227 fibrinogen beta chain Homo sapiens 58-68 23560673-6 2013 Thirteen of them were novel, including seven frameshifts (fibrinogen Aalpha: p.Asp296 fs*59, p.Thr466 fs*17 and p.Lys575 fs*74; fibrinogen Bbeta: p.Gly414 fs*2 and fibrinogen gamma: p.Ser81 fs*5, p.Lys185 fs*13 and p.Asp278_279 fs*17), three splice site mutations (FGA gene c.364+1G>A; c.510+2 T>G; FGB gene c.851+1G>A), two missense substitutions (fibrinogen Bbeta: p.Gly288Ser; p.Arg445Thr) and a nonsense mutation in fibrinogen Aalpha (p.Tyr127*). asp278_279 217-227 fibrinogen beta chain Homo sapiens 128-138 23560673-6 2013 Thirteen of them were novel, including seven frameshifts (fibrinogen Aalpha: p.Asp296 fs*59, p.Thr466 fs*17 and p.Lys575 fs*74; fibrinogen Bbeta: p.Gly414 fs*2 and fibrinogen gamma: p.Ser81 fs*5, p.Lys185 fs*13 and p.Asp278_279 fs*17), three splice site mutations (FGA gene c.364+1G>A; c.510+2 T>G; FGB gene c.851+1G>A), two missense substitutions (fibrinogen Bbeta: p.Gly288Ser; p.Arg445Thr) and a nonsense mutation in fibrinogen Aalpha (p.Tyr127*). asp278_279 217-227 fibrinogen beta chain Homo sapiens 128-138 23560673-6 2013 Thirteen of them were novel, including seven frameshifts (fibrinogen Aalpha: p.Asp296 fs*59, p.Thr466 fs*17 and p.Lys575 fs*74; fibrinogen Bbeta: p.Gly414 fs*2 and fibrinogen gamma: p.Ser81 fs*5, p.Lys185 fs*13 and p.Asp278_279 fs*17), three splice site mutations (FGA gene c.364+1G>A; c.510+2 T>G; FGB gene c.851+1G>A), two missense substitutions (fibrinogen Bbeta: p.Gly288Ser; p.Arg445Thr) and a nonsense mutation in fibrinogen Aalpha (p.Tyr127*). asp278_279 217-227 fibrinogen beta chain Homo sapiens 128-138 23560673-6 2013 Thirteen of them were novel, including seven frameshifts (fibrinogen Aalpha: p.Asp296 fs*59, p.Thr466 fs*17 and p.Lys575 fs*74; fibrinogen Bbeta: p.Gly414 fs*2 and fibrinogen gamma: p.Ser81 fs*5, p.Lys185 fs*13 and p.Asp278_279 fs*17), three splice site mutations (FGA gene c.364+1G>A; c.510+2 T>G; FGB gene c.851+1G>A), two missense substitutions (fibrinogen Bbeta: p.Gly288Ser; p.Arg445Thr) and a nonsense mutation in fibrinogen Aalpha (p.Tyr127*). asp278_279 217-227 fibrinogen beta chain Homo sapiens 128-138 24224425-7 2013 Multivariable Poisson regression analysis revealed older age, history of CVD, increasing fibrinogen, and presence of CAC were independently associated with the presence of VC. Polyvinyl Chloride 172-174 fibrinogen beta chain Homo sapiens 89-99 23642654-10 2013 Recombinant Aalpha251-truncated human fibrinogen instead behaves differently from fragment X, suggesting a role for the Bbeta residues 1-52 in inter-molecular interactions. bbeta 120-125 fibrinogen beta chain Homo sapiens 38-48 23740095-6 2013 In the transient expression experiments, mutant fibrinogen could be detected at higher level than wild-type fibrinogen in COS-7 cell lysates but not in culture media. carbonyl sulfide 122-125 fibrinogen beta chain Homo sapiens 48-58 24319981-4 2013 According to our modification, the cyanogen bromide fragments of human fibrinogen have been changed into bovine desAB-fibrin. Cyanogen Bromide 35-51 fibrinogen beta chain Homo sapiens 71-81 23826206-2 2013 LY2157299 and LY2109761 inhibited HCC cell migration on Laminin-5, Fibronectin, Vitronectin, Fibrinogen and Collagen-I and de novo phosphorylation of pSMAD2. LY-2157299 0-9 fibrinogen beta chain Homo sapiens 93-103 23826206-2 2013 LY2157299 and LY2109761 inhibited HCC cell migration on Laminin-5, Fibronectin, Vitronectin, Fibrinogen and Collagen-I and de novo phosphorylation of pSMAD2. LY2109761 14-23 fibrinogen beta chain Homo sapiens 93-103 23621148-11 2013 Also, streaming potential measurements of fibrinogen adsorption kinetics on mica were successfully interpreted in terms of this model. mica 76-80 fibrinogen beta chain Homo sapiens 42-52 24427541-3 2013 Surface nanopatterns of mercaptosilanes were designed as sites for the attachment of fibrinogen within a protein-resistant matrix of 2-[methoxy(polyethyleneoxy)propyl] trichlorosilane (PEG-silane). mercaptosilanes 24-39 fibrinogen beta chain Homo sapiens 85-95 24427541-7 2013 Images acquired with atomic force microscopy (AFM) disclose that fibrinogen attached primarily to the surface areas presenting thiol head groups, which were surrounded by PEG-silane. Sulfhydryl Compounds 127-132 fibrinogen beta chain Homo sapiens 65-75 24427541-7 2013 Images acquired with atomic force microscopy (AFM) disclose that fibrinogen attached primarily to the surface areas presenting thiol head groups, which were surrounded by PEG-silane. Polyethylene Glycols 171-174 fibrinogen beta chain Homo sapiens 65-75 23742939-8 2013 Plasma 25-hydroxyvitamin D was inversely associated with insulin, insulin resistance, triglycerides, total cholesterol, low-density lipoprotein cholesterol, and the ratio of total to high-density lipoprotein cholesterol but not with fasting glucose, apolipoprotein A1, apolipoprotein B, C-reactive protein, fibrinogen, or homocysteine. 25-hydroxyvitamin D 7-26 fibrinogen beta chain Homo sapiens 307-317 23777276-3 2013 CBAA-PAMAM-20 and fibrinogen (Fg) could coexist in solution without forming aggregation, indicating very weak interaction force between CBAA-PAMAM-20 and fibrinogen. cbaa-pamam-20 136-149 fibrinogen beta chain Homo sapiens 18-28 23822658-1 2013 In this paper, we describe a pulsed-laser desorption/ionization mass spectrometry (LDI-MS) approach for the detection of plasmin with subnanomolar sensitivity through the analysis of gold (Au) clusters desorbed from fibrinogen-modified gold nanoparticles (Fib-Au NPs) on a mixed cellulose ester membrane (MCEM). cellulose ester 279-294 fibrinogen beta chain Homo sapiens 216-226 23581432-6 2013 RESULTS: Soluble fibrinogen functioned as a natural antagonist of neutrophil functions that are dependent on MAC-1, such as the respiratory burst induced by unopsonized zymosan and adhesion to ICAM-1 and heparin. Zymosan 169-176 fibrinogen beta chain Homo sapiens 17-27 23659226-5 2013 Results showed that the preadsorbed bovine serum albumin (BSA) on the surfaces of PE-g-mPEG films could effectively inhibit subsequent adsorption of fibrinogen (Fib). monomethoxypolyethylene glycol 87-91 fibrinogen beta chain Homo sapiens 149-159 23659226-5 2013 Results showed that the preadsorbed bovine serum albumin (BSA) on the surfaces of PE-g-mPEG films could effectively inhibit subsequent adsorption of fibrinogen (Fib). monomethoxypolyethylene glycol 87-91 fibrinogen beta chain Homo sapiens 161-164 23644213-3 2013 These compounds resulted from our efforts to merge the pharmacophores of selective factor Xa inhibitor rivaroxaban with a mimic of the Arg-Gly-Asp (RGD) sequence of fibrinogen to obtain designed multiple ligands with potential antithrombotic activity. arginyl-glycyl-aspartic acid 135-146 fibrinogen beta chain Homo sapiens 165-175 23644213-4 2013 Resulting from this study, a structurally novel class of submicromolar fibrinogen GPIIb/IIIa binding inhibitor bearing 1,2,4-oxadiazol-5(4H)-one moiety is also described. 1,2,4-oxadiazol-5(4h) 119-140 fibrinogen beta chain Homo sapiens 71-81 23720861-16 2004 Extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) contain a tripeptide sequence consisting of Arg-Gly-Asp (RGD), which binds to a variety of integrins, including alphavbeta3. tripeptide K-26 89-99 fibrinogen beta chain Homo sapiens 44-54 23720861-16 2004 Extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) contain a tripeptide sequence consisting of Arg-Gly-Asp (RGD), which binds to a variety of integrins, including alphavbeta3. Arginine 123-126 fibrinogen beta chain Homo sapiens 44-54 23720861-16 2004 Extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) contain a tripeptide sequence consisting of Arg-Gly-Asp (RGD), which binds to a variety of integrins, including alphavbeta3. Glycine 127-130 fibrinogen beta chain Homo sapiens 44-54 23720861-16 2004 Extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) contain a tripeptide sequence consisting of Arg-Gly-Asp (RGD), which binds to a variety of integrins, including alphavbeta3. Aspartic Acid 131-134 fibrinogen beta chain Homo sapiens 44-54 23717569-2 2013 Srr1 is a serine-rich repeat glycoprotein of Streptococcus agalactiae that binds directly to the Aalpha chain of human fibrinogen. Serine 10-16 fibrinogen beta chain Homo sapiens 119-129 23549826-5 2013 After heparin reversal, however, significantly higher fibrinogen levels and less reduced ROTEM parameters, which reflect clot formation and firmness, were demonstrated in the treatment groups of infants and children. Heparin 6-13 fibrinogen beta chain Homo sapiens 54-64 22995323-8 2013 In subjects receiving SB-656933 50mg, sputum neutrophils and elastase were reduced compared to baseline (probability of a true reduction, 0.889 and 0.882 respectively), and free DNA reduced compared to placebo (probability of a true reduction, 0.967), while blood levels of fibrinogen, CRP and CXCL8 were increased. SB 656933 22-31 fibrinogen beta chain Homo sapiens 274-284 22177930-8 2013 After adjustment for risk factors (age, systolic blood pressure, triglycerides, low-density lipoprotein cholesterol, fibrinogen, and race), among women, height was significantly inversely associated with incident IPH (hazard ratio [HR] per SD [6.3 cm] was 0.81; 95% confidence interval [CI] 0.66-0.99; P = .04). iph 213-216 fibrinogen beta chain Homo sapiens 117-127 23517305-12 2013 Glu(57") and Glu(58") present in the hirudin family of inhibitors make up a key binding epitope of fibrinogen, thrombin"s prime substrate, which lends substantial interest to the short hydrogen bond as a binding element at the fibrinogen recognition site. Glutamic Acid 0-3 fibrinogen beta chain Homo sapiens 99-109 23517305-12 2013 Glu(57") and Glu(58") present in the hirudin family of inhibitors make up a key binding epitope of fibrinogen, thrombin"s prime substrate, which lends substantial interest to the short hydrogen bond as a binding element at the fibrinogen recognition site. Glutamic Acid 0-3 fibrinogen beta chain Homo sapiens 227-237 23517305-12 2013 Glu(57") and Glu(58") present in the hirudin family of inhibitors make up a key binding epitope of fibrinogen, thrombin"s prime substrate, which lends substantial interest to the short hydrogen bond as a binding element at the fibrinogen recognition site. Glutamic Acid 13-16 fibrinogen beta chain Homo sapiens 99-109 23517305-12 2013 Glu(57") and Glu(58") present in the hirudin family of inhibitors make up a key binding epitope of fibrinogen, thrombin"s prime substrate, which lends substantial interest to the short hydrogen bond as a binding element at the fibrinogen recognition site. Glutamic Acid 13-16 fibrinogen beta chain Homo sapiens 227-237 23517305-12 2013 Glu(57") and Glu(58") present in the hirudin family of inhibitors make up a key binding epitope of fibrinogen, thrombin"s prime substrate, which lends substantial interest to the short hydrogen bond as a binding element at the fibrinogen recognition site. Hydrogen 185-193 fibrinogen beta chain Homo sapiens 99-109 23517305-12 2013 Glu(57") and Glu(58") present in the hirudin family of inhibitors make up a key binding epitope of fibrinogen, thrombin"s prime substrate, which lends substantial interest to the short hydrogen bond as a binding element at the fibrinogen recognition site. Hydrogen 185-193 fibrinogen beta chain Homo sapiens 227-237 23849212-4 2013 The assessment of the fibrinogen as a predictor variable has been calculated after adjusting it by age, hypertension, diabetes mellitus, obesity, total cholesterol, HDL-cholesterol/triglycerides ratio, and smoking habit applying a Cox regression model. Cholesterol 152-163 fibrinogen beta chain Homo sapiens 22-32 23849212-4 2013 The assessment of the fibrinogen as a predictor variable has been calculated after adjusting it by age, hypertension, diabetes mellitus, obesity, total cholesterol, HDL-cholesterol/triglycerides ratio, and smoking habit applying a Cox regression model. Cholesterol 169-180 fibrinogen beta chain Homo sapiens 22-32 23849212-4 2013 The assessment of the fibrinogen as a predictor variable has been calculated after adjusting it by age, hypertension, diabetes mellitus, obesity, total cholesterol, HDL-cholesterol/triglycerides ratio, and smoking habit applying a Cox regression model. Triglycerides 181-194 fibrinogen beta chain Homo sapiens 22-32 23596488-7 2013 The plasma D-dimer and FIB levels had significantly positive correlations with the partial pressure of CO2 (PaCO2) and negative correlations with the partial pressure of O2 (PaO2) in the patients with AECOPD combined with respiratory failure. N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)-4-((4-fluorobenzyl)oxy)pyridine-2,6-dicarboxamide 103-106 fibrinogen beta chain Homo sapiens 23-26 23596488-7 2013 The plasma D-dimer and FIB levels had significantly positive correlations with the partial pressure of CO2 (PaCO2) and negative correlations with the partial pressure of O2 (PaO2) in the patients with AECOPD combined with respiratory failure. paco2 108-113 fibrinogen beta chain Homo sapiens 23-26 23596488-7 2013 The plasma D-dimer and FIB levels had significantly positive correlations with the partial pressure of CO2 (PaCO2) and negative correlations with the partial pressure of O2 (PaO2) in the patients with AECOPD combined with respiratory failure. Oxygen 104-106 fibrinogen beta chain Homo sapiens 23-26 23596488-7 2013 The plasma D-dimer and FIB levels had significantly positive correlations with the partial pressure of CO2 (PaCO2) and negative correlations with the partial pressure of O2 (PaO2) in the patients with AECOPD combined with respiratory failure. pao2 174-178 fibrinogen beta chain Homo sapiens 23-26 23596488-7 2013 The plasma D-dimer and FIB levels had significantly positive correlations with the partial pressure of CO2 (PaCO2) and negative correlations with the partial pressure of O2 (PaO2) in the patients with AECOPD combined with respiratory failure. aecopd 201-207 fibrinogen beta chain Homo sapiens 23-26 23175390-2 2013 One such modification is citrullination, which is catalyzed by the protein arginine deiminases (PADs), a unique family of enzymes that catalyzes the hydrolysis of peptidyl-arginine to form peptidyl-citrulline on histones, fibrinogen, and other biologically relevant proteins. peptidyl-arginine 163-180 fibrinogen beta chain Homo sapiens 222-232 23357800-3 2013 The reaction of fibrinogen with peroxynitrite causes both structural modifications and changes of the biological properties of this plasma glycoprotein. Peroxynitrous Acid 32-45 fibrinogen beta chain Homo sapiens 16-26 23357800-7 2013 The extract also abolished peroxynitrite-induced inhibition of fibrinogen polymerization (by 95% at 50 mug/ml). Peroxynitrous Acid 27-40 fibrinogen beta chain Homo sapiens 63-73 23357800-8 2013 The obtained results indicate that natural extract from berries of A. melanocarpa has protective effects against peroxynitrite-induced nitrative damage of plasma fibrinogen, and therefore may contribute in the prevention of peroxynitrite-related cardiovascular or inflammatory diseases. Peroxynitrous Acid 113-126 fibrinogen beta chain Homo sapiens 162-172 23357800-8 2013 The obtained results indicate that natural extract from berries of A. melanocarpa has protective effects against peroxynitrite-induced nitrative damage of plasma fibrinogen, and therefore may contribute in the prevention of peroxynitrite-related cardiovascular or inflammatory diseases. Peroxynitrous Acid 224-237 fibrinogen beta chain Homo sapiens 162-172 23380398-0 2013 Fibrinogen adsorption on zinc oxide nanoparticles: a Micro-Differential Scanning Calorimetry analysis. Zinc Oxide 25-35 fibrinogen beta chain Homo sapiens 0-10 23380398-2 2013 The aim of this work is the study of the interaction of fibrinogen (Fib) with zinc oxide nanoparticles. Zinc Oxide 78-88 fibrinogen beta chain Homo sapiens 56-66 23380398-2 2013 The aim of this work is the study of the interaction of fibrinogen (Fib) with zinc oxide nanoparticles. Zinc Oxide 78-88 fibrinogen beta chain Homo sapiens 68-71 23380398-9 2013 The discrepancy between the Fib adsorption percentages on homemade and commercially available zinc oxide nanoparticles can be attributed to their different size. Zinc Oxide 94-104 fibrinogen beta chain Homo sapiens 28-31 23445486-6 2013 Mean values for prothrombin time (PT), international normalized ratio (INR), activated partial thromboplastin time (aPTT), and d-dimer obtained on the first day were significantly higher in the PA group compared to healthy controls (P <= .001 for all comparisons), whereas platelet count, levels of fibrinogen, factors II, V, VII, IX, X, and XI were significantly lower (P <= .005 for all comparisons). Protactinium 194-196 fibrinogen beta chain Homo sapiens 302-312 23570413-4 2013 Platelet activation was measured by P-selectin expression and by the amount of platelet-bound fibrinogen after stimulation with adenosine di phosphate (ADP), collagen-related peptide and the protease activated receptor (thrombin receptor) (PAR)-activating peptides PAR4-AP and PAR1-AP. Adenosine Diphosphate 128-150 fibrinogen beta chain Homo sapiens 94-104 23570413-4 2013 Platelet activation was measured by P-selectin expression and by the amount of platelet-bound fibrinogen after stimulation with adenosine di phosphate (ADP), collagen-related peptide and the protease activated receptor (thrombin receptor) (PAR)-activating peptides PAR4-AP and PAR1-AP. Adenosine Diphosphate 152-155 fibrinogen beta chain Homo sapiens 94-104 23517637-10 2013 After addition of fibrinogen, coagulation time shortened and elasticity increased, with the exception of fibrinogen-dependent clot strength (i.e., elasticity in the presence of a platelet inhibitor) after hydroxyethyl starch haemodilution. Hydroxyethyl starch 205-224 fibrinogen beta chain Homo sapiens 105-115 23517637-11 2013 Factor XIII had an additional effect with fibrinogen on fibrinogen-dependent clot strength in blood diluted with Ringer"s acetate solution. Acetates 122-129 fibrinogen beta chain Homo sapiens 56-66 23517637-15 2013 Addition of fibrinogen with factor XIII was unable to reverse hydroxyethyl starch induced clot instability, but improved coagulation in blood diluted with Ringer"s acetate solution. Acetates 164-171 fibrinogen beta chain Homo sapiens 12-22 23421850-1 2013 The adsorption of human serum fibrinogen on polystyrene latex particles was studied using the microelectrophoretic and concentration depletion methods. Polystyrenes 44-55 fibrinogen beta chain Homo sapiens 30-40 23421850-3 2013 The electrophoretic mobility of latex was determined as a function of the amount of adsorbed fibrinogen (surface concentration). Latex 32-37 fibrinogen beta chain Homo sapiens 93-103 23421850-7 2013 The residual protein concentration after making contact with latex particles was determined by electrokinetic measurements and AFM imaging where the surface coverage of fibrinogen on mica was quantitatively determined. mica 183-187 fibrinogen beta chain Homo sapiens 169-179 23421850-8 2013 The maximum fibrinogen coverage increased monotonically with ionic strength from 1.8 mg m(-2) for 10(-3) M NaCl to 3.6 mg m(-2) for 0.15 M NaCl. Sodium Chloride 107-111 fibrinogen beta chain Homo sapiens 12-22 23421850-8 2013 The maximum fibrinogen coverage increased monotonically with ionic strength from 1.8 mg m(-2) for 10(-3) M NaCl to 3.6 mg m(-2) for 0.15 M NaCl. Sodium Chloride 139-143 fibrinogen beta chain Homo sapiens 12-22 23315163-5 2013 Sialidase treatment of fibrinogen reversed the suppressive effect of siglec-E on CD11b signaling, suggesting that sialic acid recognition by siglec-E is required for its inhibitory function. N-Acetylneuraminic Acid 114-125 fibrinogen beta chain Homo sapiens 23-33 23324826-3 2013 The fibrinogen was immobilized on the surface of 96-well plate offering reactive N-oxysuccinimide esters (referred to as NOS group) surface. n-oxysuccinimide esters 81-104 fibrinogen beta chain Homo sapiens 4-14 23402628-1 2013 Selective oxidation of omega-tertiary amine self-assembled thiol monolayers to tertiary amine N-oxides is shown to transform the adhesion of model proteins lysozyme and fibrinogen upon them. omega-tertiary amine 23-43 fibrinogen beta chain Homo sapiens 169-179 23402628-1 2013 Selective oxidation of omega-tertiary amine self-assembled thiol monolayers to tertiary amine N-oxides is shown to transform the adhesion of model proteins lysozyme and fibrinogen upon them. Sulfhydryl Compounds 59-64 fibrinogen beta chain Homo sapiens 169-179 23402628-1 2013 Selective oxidation of omega-tertiary amine self-assembled thiol monolayers to tertiary amine N-oxides is shown to transform the adhesion of model proteins lysozyme and fibrinogen upon them. tertiary 29-37 fibrinogen beta chain Homo sapiens 169-179 23402628-1 2013 Selective oxidation of omega-tertiary amine self-assembled thiol monolayers to tertiary amine N-oxides is shown to transform the adhesion of model proteins lysozyme and fibrinogen upon them. amine n-oxides 88-102 fibrinogen beta chain Homo sapiens 169-179 23402628-3 2013 Oxidation with hydrogen peroxide was similarly assessed, and adhesion of lysozyme and fibrinogen from phosphate buffered saline was then assayed by QCM and imaged by AFM. Phosphate-Buffered Saline 102-127 fibrinogen beta chain Homo sapiens 86-96 23755552-8 2013 Fibrinogen-induced aggregation of echinocytes, obtained after treatment with lysophosphatidic acid and produced by ATP depletion, was also greatly reduced. lysophosphatidic acid 77-98 fibrinogen beta chain Homo sapiens 0-10 23755552-8 2013 Fibrinogen-induced aggregation of echinocytes, obtained after treatment with lysophosphatidic acid and produced by ATP depletion, was also greatly reduced. Adenosine Triphosphate 115-118 fibrinogen beta chain Homo sapiens 0-10 23266225-0 2013 A novel mutation in the FGB: c.1105C>T turns the codon for amino acid Bbeta Q339 into a stop codon causing hypofibrinogenemia. amino acid bbeta 62-78 fibrinogen beta chain Homo sapiens 24-27 23266225-2 2013 His father showed similar aberrant results and sequencing of the three fibrinogen genes revealed a novel heterozygous nonsense mutation in the FGB gene c.1105C>T, which converts the codon for residue Bbeta 339Q to stop, causing deletion of Bbeta chain residues 339-461. bbeta 203-208 fibrinogen beta chain Homo sapiens 71-81 23266225-2 2013 His father showed similar aberrant results and sequencing of the three fibrinogen genes revealed a novel heterozygous nonsense mutation in the FGB gene c.1105C>T, which converts the codon for residue Bbeta 339Q to stop, causing deletion of Bbeta chain residues 339-461. bbeta 203-208 fibrinogen beta chain Homo sapiens 143-146 23266225-2 2013 His father showed similar aberrant results and sequencing of the three fibrinogen genes revealed a novel heterozygous nonsense mutation in the FGB gene c.1105C>T, which converts the codon for residue Bbeta 339Q to stop, causing deletion of Bbeta chain residues 339-461. bbeta 243-248 fibrinogen beta chain Homo sapiens 71-81 23266225-2 2013 His father showed similar aberrant results and sequencing of the three fibrinogen genes revealed a novel heterozygous nonsense mutation in the FGB gene c.1105C>T, which converts the codon for residue Bbeta 339Q to stop, causing deletion of Bbeta chain residues 339-461. bbeta 243-248 fibrinogen beta chain Homo sapiens 143-146 23266225-3 2013 Sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) and RP-HPLC (reverse-phase high-pressure liquid chromatography) of purified fibrinogen showed only normal Aalpha, Bbeta, and gamma chains, indicating that molecules with the truncated 37,990Da beta chain were not secreted into plasma. Sodium Dodecyl Sulfate 0-22 fibrinogen beta chain Homo sapiens 145-155 23465926-0 2013 Viscoelastic properties of fibrinogen adsorbed onto poly(ethylene terephthalate) surfaces by QCM-D. Polyethylene Terephthalates 52-80 fibrinogen beta chain Homo sapiens 27-37 23465926-5 2013 The results showed that PET surfaces coated with sulphated polysaccharides are more hydrophilic and more fibrinogen-repulsive than non-modified PET surfaces. Polysaccharides 59-74 fibrinogen beta chain Homo sapiens 105-115 23250949-7 2013 The percentage of vegetation infection relative to that with strain pIL253 (11%) increased when binding to fibrinogen was conferred on L. lactis (ClfA strain) (52%; P = 0.007) and increased further with adhesion to fibronectin (FnbpA strain) (75%; P < 0.001). clfa 146-150 fibrinogen beta chain Homo sapiens 107-117 23250949-7 2013 The percentage of vegetation infection relative to that with strain pIL253 (11%) increased when binding to fibrinogen was conferred on L. lactis (ClfA strain) (52%; P = 0.007) and increased further with adhesion to fibronectin (FnbpA strain) (75%; P < 0.001). fnbpa 228-233 fibrinogen beta chain Homo sapiens 107-117 23151385-5 2013 The results show that the adsorbed mass of fibrinogen decreased linearly with increasing CF(3)/CF(2) ratio on the fluorinated polymer surfaces. Polymers 126-133 fibrinogen beta chain Homo sapiens 43-53 23280783-10 2013 We conclude that SEM is a very effective tool for the visualization of circulatory consequences of the interaction of iron-induced hydroxyl radicals with human fibrinogen. Iron 118-122 fibrinogen beta chain Homo sapiens 160-170 23280783-10 2013 We conclude that SEM is a very effective tool for the visualization of circulatory consequences of the interaction of iron-induced hydroxyl radicals with human fibrinogen. induced hydroxyl radicals 123-148 fibrinogen beta chain Homo sapiens 160-170 23280783-11 2013 Furthermore, this novel fibrinogen model provides a convenient method to study the interactions of the intramolecular and intermolecular hydrophobic forces responsible for the maintenance of the tertiary structure of native fibrin(ogen) and the prevention of iron-induced DMDs formation by hydrophilic agents. Iron 259-263 fibrinogen beta chain Homo sapiens 24-34 22889109-9 2013 RESULTS: Compared to cryoprecipitation, all other considered methods were superior in quantitative analyses, with maximum fibrinogen yields of ~80% of total plasma fibrinogen concentration using ethanol precipitation. Ethanol 195-202 fibrinogen beta chain Homo sapiens 122-132 22889109-9 2013 RESULTS: Compared to cryoprecipitation, all other considered methods were superior in quantitative analyses, with maximum fibrinogen yields of ~80% of total plasma fibrinogen concentration using ethanol precipitation. Ethanol 195-202 fibrinogen beta chain Homo sapiens 164-174 22889109-15 2013 CONCLUSION: The results of the present study demonstrated that ethanol precipitation is a simple and effective method for isolation of fibrinogen and a suitable alternative to cryoprecipitation. Ethanol 63-70 fibrinogen beta chain Homo sapiens 135-145 22738354-5 2013 RESULTS: The content of fibrinogen, FVIII, and ADAMTS-13 was lower in cryoprecipitates prepared from amotosalen-treated plasma when compared with cryoprecipitates prepared from nontreated plasma (35, 40, and 18% loss, respectively). amotosalen 101-111 fibrinogen beta chain Homo sapiens 24-34 22738354-7 2013 CONCLUSION: Cryoprecipitates prepared from amotosalen-treated FFP contained significantly reduced levels of fibrinogen, FVIII, and ADAMTS-13. amotosalen 43-53 fibrinogen beta chain Homo sapiens 108-118 23683413-10 2013 The genotype analysis showed that Arg275His in fibrinogen gamma chain (gamma Arg275His) existed in both probands and patients in these two pedigrees. gamma arg275his 71-86 fibrinogen beta chain Homo sapiens 47-57 23175390-2 2013 One such modification is citrullination, which is catalyzed by the protein arginine deiminases (PADs), a unique family of enzymes that catalyzes the hydrolysis of peptidyl-arginine to form peptidyl-citrulline on histones, fibrinogen, and other biologically relevant proteins. peptidyl-citrulline 189-208 fibrinogen beta chain Homo sapiens 222-232 23240658-6 2013 Compared with weekly dexamethasone, pulsed dexamethasone was associated with significantly greater variation in mean adjusted relative values of fibrinogen, P-selectin and vascular endothelial growth factor (P < 0 001 for all comparisons), although there was no apparent association with VTE incidence. Dexamethasone 43-56 fibrinogen beta chain Homo sapiens 145-155 23108037-4 2013 Blood compatibility was tested by measuring platelet activation and fibrinogen adsorption on poly (DL-lactide-co-glycolide, PLGA) films. poly (dl-lactide-co-glycolide 93-122 fibrinogen beta chain Homo sapiens 68-78 23165896-9 2013 Rather, mpICs display autoantigens vimentin and fibrinogen, and recognition of these targets by anti-citrullinated peptide antibodies contributes to the production of mpICs. mpics 8-13 fibrinogen beta chain Homo sapiens 48-58 23108037-9 2013 In addition, we observed an increase of fibrinogen adsorption to PLGA-films containing curcumin. Curcumin 87-95 fibrinogen beta chain Homo sapiens 40-50 23259461-5 2013 Guanidinium-containing NPs showed the highest affinity to fibrinogen. Guanidine 0-11 fibrinogen beta chain Homo sapiens 58-68 23259461-9 2013 Engineered NPs containing the guanidinium group with hydrophobic and hydrogen bonding functional groups were used in an affinity precipitation for the selective separation of fibrinogen from a plasma protein mixture. Guanidine 30-41 fibrinogen beta chain Homo sapiens 175-185 23287370-3 2013 Elevated fibrinogen also contributes to high on-clopidogrel platelet reactivity. Clopidogrel 48-59 fibrinogen beta chain Homo sapiens 9-19 23287370-14 2013 CONCLUSIONS: Elevated fibrinogen is independently associated with the risk of ischemic myocardial injury following elective PCI with clopidogrel pre-treatment regardless of platelet reactivity as measured by the VerifyNow assay. Clopidogrel 133-144 fibrinogen beta chain Homo sapiens 22-32 23151259-0 2013 Characterization of fibrinogen glycosylation and its importance for serum/plasma N-glycome analysis. Nitrogen 81-82 fibrinogen beta chain Homo sapiens 20-30 23151259-3 2013 Our aim was to characterize fibrinogen glycosylation in order to determine its contribution to differences between serum and plasma N-glycomes. Nitrogen 132-133 fibrinogen beta chain Homo sapiens 28-38 23151259-8 2013 N-Glycan profiles from serum and plasma samples differed largely in glycans identified in fibrinogen, suggesting that this glycoprotein represents a major factor distinguishing these body fluids. n-glycan 0-8 fibrinogen beta chain Homo sapiens 90-100 23151259-4 2013 N-Glycans from human fibrinogen were released, labeled, and analyzed by HILIC-HPLC and MS. n-glycans 0-9 fibrinogen beta chain Homo sapiens 21-31 23151259-8 2013 N-Glycan profiles from serum and plasma samples differed largely in glycans identified in fibrinogen, suggesting that this glycoprotein represents a major factor distinguishing these body fluids. Polysaccharides 68-75 fibrinogen beta chain Homo sapiens 90-100 23037322-9 2013 Ks and t50% were associated with Lp(a) (r = -0.42, P < 0.00001 and r = 0.42, P < 0.00001, respectively) and fibrinogen (r = -0.31, P = 0.00024 and r = 0.39, P < 0.00001, respectively). Potassium 0-2 fibrinogen beta chain Homo sapiens 114-124 24222906-7 2013 S. mutans in biofilms induced by the presence of fibrinogen was markedly resistant to the bactericidal effect of penicillin. Penicillins 113-123 fibrinogen beta chain Homo sapiens 49-59 22960295-2 2013 The protein membrane RBC target for fibrinogen is also highlight as well as the erythrocyte signal transduction pathway associated with nitric oxide mobilization resulting from its binding. Nitric Oxide 136-148 fibrinogen beta chain Homo sapiens 36-46 23089881-2 2013 In this study, we investigated the effects of cell deformability and fibrinogen concentration on disaggregating shear stress (DSS). dss 126-129 fibrinogen beta chain Homo sapiens 69-79 23089881-6 2013 The effect of cell deformability on DSS was significantly increased with an increase in fibrinogen concentration (2~6 g/L). dss 36-39 fibrinogen beta chain Homo sapiens 88-98 23089881-7 2013 These results imply that reduced cell deformability and increased fibrinogen levels play a synergistic role in increasing DSS, which could be used as a novel independent hemorheological index to characterize microcirculatory diseases, such as diabetic complications with high sensitivity. dss 122-125 fibrinogen beta chain Homo sapiens 66-76 23170793-4 2013 We have recently shown that trivalent iron (ferric ions) generates hydroxyl radicals, which subsequently convert FBG into abnormal fibrin clots in the form of DMDs. Iron 38-42 fibrinogen beta chain Homo sapiens 113-116 23170793-4 2013 We have recently shown that trivalent iron (ferric ions) generates hydroxyl radicals, which subsequently convert FBG into abnormal fibrin clots in the form of DMDs. Ferric enterobactin ion 44-50 fibrinogen beta chain Homo sapiens 113-116 23170793-4 2013 We have recently shown that trivalent iron (ferric ions) generates hydroxyl radicals, which subsequently convert FBG into abnormal fibrin clots in the form of DMDs. Hydroxyl Radical 67-84 fibrinogen beta chain Homo sapiens 113-116 23767099-0 2013 [Estimating ability of dihydroquercetin to inhibit oxidation of fibrinogen by ozone]. taxifolin 23-39 fibrinogen beta chain Homo sapiens 64-74 23767099-1 2013 The ability of dihydroquercetin to inhibit the oxidation of fibrinogen has been evaluated. taxifolin 15-31 fibrinogen beta chain Homo sapiens 60-70 23767099-2 2013 It is established that dihydroquercetin inhibits oxidation of fibrinogen by ozone, thus preventing oxidative modification of fibrinogen and preserving its functional activity. taxifolin 23-39 fibrinogen beta chain Homo sapiens 62-72 23767099-2 2013 It is established that dihydroquercetin inhibits oxidation of fibrinogen by ozone, thus preventing oxidative modification of fibrinogen and preserving its functional activity. taxifolin 23-39 fibrinogen beta chain Homo sapiens 125-135 23565690-7 2013 It was found that both platelet adhesion and fibrinogen adsorption decreased with increasing copolymer content in the blends and with decreasing PEO block size for a given copolymer content. copolymer 93-102 fibrinogen beta chain Homo sapiens 45-55 23565690-7 2013 It was found that both platelet adhesion and fibrinogen adsorption decreased with increasing copolymer content in the blends and with decreasing PEO block size for a given copolymer content. copolymer 172-181 fibrinogen beta chain Homo sapiens 45-55 24437188-3 2013 It was shown that light scattering index significantly correlated with ADP-, adrenalin-, or collagen-induced platelet aggregation, with the formation of leukocyte-erythrocyte or platelet-erythrocyte aggregates, and with the levels of fibrinogen, soluble fibrin-monomer complexes and related parameters. Adenosine Diphosphate 71-74 fibrinogen beta chain Homo sapiens 234-244 23563040-3 2013 RESULTS: Twelve-week treatment with fenofibrate and metformin reduced plasma levels of fibrinogen and PAI-1 and tended to change the other hemostatic markers measured, as well as improved insulin sensitivity. Fenofibrate 36-47 fibrinogen beta chain Homo sapiens 87-97 23563040-3 2013 RESULTS: Twelve-week treatment with fenofibrate and metformin reduced plasma levels of fibrinogen and PAI-1 and tended to change the other hemostatic markers measured, as well as improved insulin sensitivity. Metformin 52-61 fibrinogen beta chain Homo sapiens 87-97 22994591-12 2013 The time course of plasma fibrinogen and procalcitonin levels indicate that ASA seems to reduce the activation of haemostasis and increase the resolution of inflammation. Aspirin 76-79 fibrinogen beta chain Homo sapiens 26-36 23177973-6 2013 After multivariable adjustments, fibrinogen generally rose with increasing BMI (p < 0.001; all sex/race groups), LDL cholesterol, log triglycerides and diastolic blood pressure; and fell with increasing HDL cholesterol and physical activity. Cholesterol 120-131 fibrinogen beta chain Homo sapiens 33-43 23177973-6 2013 After multivariable adjustments, fibrinogen generally rose with increasing BMI (p < 0.001; all sex/race groups), LDL cholesterol, log triglycerides and diastolic blood pressure; and fell with increasing HDL cholesterol and physical activity. Triglycerides 137-150 fibrinogen beta chain Homo sapiens 33-43 23177973-6 2013 After multivariable adjustments, fibrinogen generally rose with increasing BMI (p < 0.001; all sex/race groups), LDL cholesterol, log triglycerides and diastolic blood pressure; and fell with increasing HDL cholesterol and physical activity. Cholesterol 210-221 fibrinogen beta chain Homo sapiens 33-43 23285494-13 2004 The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3. Arginine 21-24 fibrinogen beta chain Homo sapiens 134-144 22999413-9 2013 Addition of NETA downregulated fibrinogen and prothrombin. Norethindrone Acetate 12-16 fibrinogen beta chain Homo sapiens 31-41 23285494-13 2004 The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3. Glycine 25-28 fibrinogen beta chain Homo sapiens 134-144 23285494-13 2004 The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3. Aspartic Acid 29-32 fibrinogen beta chain Homo sapiens 134-144 23231781-7 2012 RESULTS: We found consistent positive associations between the following biomarkers and PM(2.5) chemical constituents across different models: TNF-alpha with secondary organic carbon, chloride, zinc, molybdenum and stannum; fibrinogen with magnesium, iron, titanium, cobalt and cadmium; PAI-1 with titanium, cobalt and manganese; t-PA with cadmium and selenium; vWF with aluminum. Magnesium 240-249 fibrinogen beta chain Homo sapiens 224-234 23061093-3 2012 Addition of fibrinogen to the CuInS(2) QDs solution led to the formation of a Fib-CuInS(2) QDs complex through electrostatic interactions and hydrogen bonding, and resulting in the enhancement of photoluminescence (PL) intensity and a red shift of the PL peak. Hydrogen 142-150 fibrinogen beta chain Homo sapiens 12-22 23061093-3 2012 Addition of fibrinogen to the CuInS(2) QDs solution led to the formation of a Fib-CuInS(2) QDs complex through electrostatic interactions and hydrogen bonding, and resulting in the enhancement of photoluminescence (PL) intensity and a red shift of the PL peak. Hydrogen 142-150 fibrinogen beta chain Homo sapiens 78-81 23050552-8 2012 The previously reported N-glycan attachment sites of human fibrinogen could be confirmed. n-glycan 24-32 fibrinogen beta chain Homo sapiens 59-69 23283239-0 2012 Fibrin clot structure and mechanics associated with specific oxidation of methionine residues in fibrinogen. Methionine 74-84 fibrinogen beta chain Homo sapiens 97-107 23283239-2 2012 We find that treatment with hypochlorous acid preferentially oxidizes specific methionine residues on the alpha, beta, and gamma chains of fibrinogen. Hypochlorous Acid 28-45 fibrinogen beta chain Homo sapiens 139-149 23283239-2 2012 We find that treatment with hypochlorous acid preferentially oxidizes specific methionine residues on the alpha, beta, and gamma chains of fibrinogen. Methionine 79-89 fibrinogen beta chain Homo sapiens 139-149 23239003-4 2012 RESULTS: The level of fibrinogen and neutrophil count in thick fur group were significantly higher than that in thin fur group (P<0.05). fur 63-66 fibrinogen beta chain Homo sapiens 22-32 23232017-0 2012 Dabigatran effects on the international normalized ratio, activated partial thromboplastin time, thrombin time, and fibrinogen: a multicenter, in vitro study. Dabigatran 0-10 fibrinogen beta chain Homo sapiens 116-126 23232017-8 2012 Measured fibrinogen either demonstrated no change or factitious decrease with increasing dabigatran concentrations. Dabigatran 89-99 fibrinogen beta chain Homo sapiens 9-19 23232017-13 2012 Fibrinogen test results may be either unaffected or lower in the presence of dabigatran. Dabigatran 77-87 fibrinogen beta chain Homo sapiens 0-10 22875482-0 2012 Adsorption of fibronectin, fibrinogen, and albumin on TiO2: time-resolved kinetics, structural changes, and competition study. titanium dioxide 54-58 fibrinogen beta chain Homo sapiens 27-37 22642405-0 2012 Endogenous oestradiol as a positive correlate of plasma fibrinogen among older postmenopausal women: a population-based study (the Three-City cohort study). Estradiol 11-21 fibrinogen beta chain Homo sapiens 56-66 22642405-3 2012 However, whether endogenous sex steroid hormones influence the plasma fibrinogen concentrations among postmenopausal women remains unclear. Steroids 32-48 fibrinogen beta chain Homo sapiens 70-80 22642405-4 2012 OBJECTIVES: To investigate the association of plasma fibrinogen levels with endogenous sex steroid hormones and sex hormone binding globulin (SHBG) among postmenopausal women. Steroids 91-107 fibrinogen beta chain Homo sapiens 53-63 22642405-7 2012 Multivariate linear regression models were used to estimate the regression coefficients assessed in fibrinogen unit by 1 SD increase in log-distribution of sex steroid hormones and SHBG. Steroids 160-176 fibrinogen beta chain Homo sapiens 100-110 23239003-7 2012 The level of fibrinogen and the neutrophil count were compared among different fur color groups, revealing that the level of fibrinogen in yellowish fur group was higher than that of white fur group and normal value with statistical significance (P<0.05) with neutrophil count in yellowish fur group being significantly higher than that in white fur group. fur 149-152 fibrinogen beta chain Homo sapiens 125-135 23239003-7 2012 The level of fibrinogen and the neutrophil count were compared among different fur color groups, revealing that the level of fibrinogen in yellowish fur group was higher than that of white fur group and normal value with statistical significance (P<0.05) with neutrophil count in yellowish fur group being significantly higher than that in white fur group. fur 149-152 fibrinogen beta chain Homo sapiens 125-135 23239003-7 2012 The level of fibrinogen and the neutrophil count were compared among different fur color groups, revealing that the level of fibrinogen in yellowish fur group was higher than that of white fur group and normal value with statistical significance (P<0.05) with neutrophil count in yellowish fur group being significantly higher than that in white fur group. fur 149-152 fibrinogen beta chain Homo sapiens 125-135 23239003-6 2012 Statistical significance existed in the level of fibrinogen between the greasy tongue fur group and non-greasy tongue fur group (P<0.05). fur 86-89 fibrinogen beta chain Homo sapiens 49-59 23239003-6 2012 Statistical significance existed in the level of fibrinogen between the greasy tongue fur group and non-greasy tongue fur group (P<0.05). fur 118-121 fibrinogen beta chain Homo sapiens 49-59 23239003-7 2012 The level of fibrinogen and the neutrophil count were compared among different fur color groups, revealing that the level of fibrinogen in yellowish fur group was higher than that of white fur group and normal value with statistical significance (P<0.05) with neutrophil count in yellowish fur group being significantly higher than that in white fur group. fur 79-82 fibrinogen beta chain Homo sapiens 125-135 23239003-7 2012 The level of fibrinogen and the neutrophil count were compared among different fur color groups, revealing that the level of fibrinogen in yellowish fur group was higher than that of white fur group and normal value with statistical significance (P<0.05) with neutrophil count in yellowish fur group being significantly higher than that in white fur group. fur 149-152 fibrinogen beta chain Homo sapiens 125-135 23144467-6 2012 The effect of fenofibrate treatment on serum FGF21, but not RBP4, remained significant after adjusting for fenofibrate-induced changes in glycosylated hemoglobin, total cholesterol, triglycerides, apolipoprotein A-II, fibrinogen, plasma creatinine, and homocysteine (P = 0.002). Fenofibrate 14-25 fibrinogen beta chain Homo sapiens 218-228 24749013-0 2012 Fibrinogen - a possible extracellular target for inositol phosphates. Inositol Phosphates 49-68 fibrinogen beta chain Homo sapiens 0-10 24749013-4 2012 Inositol phosphates and analogues were able to elute purified fibrinogen from this matrix. Inositol Phosphates 0-19 fibrinogen beta chain Homo sapiens 62-72 24749013-5 2012 InsP5 and the inositol phosphate mimic biphenyl 2,3",4,5",6-pentakisphosphate (BiPhP5) bind fibrinogen in vitro, and block the effects of fibrinogen in A549 cell-based assays of proliferation and migration. Inositol Phosphates 14-32 fibrinogen beta chain Homo sapiens 92-102 24749013-5 2012 InsP5 and the inositol phosphate mimic biphenyl 2,3",4,5",6-pentakisphosphate (BiPhP5) bind fibrinogen in vitro, and block the effects of fibrinogen in A549 cell-based assays of proliferation and migration. Inositol Phosphates 14-32 fibrinogen beta chain Homo sapiens 138-148 24749013-5 2012 InsP5 and the inositol phosphate mimic biphenyl 2,3",4,5",6-pentakisphosphate (BiPhP5) bind fibrinogen in vitro, and block the effects of fibrinogen in A549 cell-based assays of proliferation and migration. biphenyl 2,3',4,5',6-pentakisphosphate 39-77 fibrinogen beta chain Homo sapiens 92-102 24749013-5 2012 InsP5 and the inositol phosphate mimic biphenyl 2,3",4,5",6-pentakisphosphate (BiPhP5) bind fibrinogen in vitro, and block the effects of fibrinogen in A549 cell-based assays of proliferation and migration. biphenyl 2,3',4,5',6-pentakisphosphate 39-77 fibrinogen beta chain Homo sapiens 138-148 24749013-5 2012 InsP5 and the inositol phosphate mimic biphenyl 2,3",4,5",6-pentakisphosphate (BiPhP5) bind fibrinogen in vitro, and block the effects of fibrinogen in A549 cell-based assays of proliferation and migration. biphp5 79-85 fibrinogen beta chain Homo sapiens 92-102 24749013-5 2012 InsP5 and the inositol phosphate mimic biphenyl 2,3",4,5",6-pentakisphosphate (BiPhP5) bind fibrinogen in vitro, and block the effects of fibrinogen in A549 cell-based assays of proliferation and migration. biphp5 79-85 fibrinogen beta chain Homo sapiens 138-148 23166958-11 2004 A peptide sequence consisting of Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3. arginyl-glycyl-aspartic acid 33-44 fibrinogen beta chain Homo sapiens 146-156 22796369-0 2012 Fibrinogen effects on erythrocyte nitric oxide mobilization in presence of acetylcholine. Nitric Oxide 34-46 fibrinogen beta chain Homo sapiens 0-10 22796369-0 2012 Fibrinogen effects on erythrocyte nitric oxide mobilization in presence of acetylcholine. Acetylcholine 75-88 fibrinogen beta chain Homo sapiens 0-10 22796369-1 2012 AIMS: The objectives of this study were to evaluate the effects of high fibrinogen concentration on erythrocyte deformability on mobilization of nitric oxide (NO) and of its metabolites in the presence of acetylcholine (ACh) in healthy human blood samples. Nitric Oxide 145-157 fibrinogen beta chain Homo sapiens 72-82 22796369-1 2012 AIMS: The objectives of this study were to evaluate the effects of high fibrinogen concentration on erythrocyte deformability on mobilization of nitric oxide (NO) and of its metabolites in the presence of acetylcholine (ACh) in healthy human blood samples. Acetylcholine 205-218 fibrinogen beta chain Homo sapiens 72-82 22796369-1 2012 AIMS: The objectives of this study were to evaluate the effects of high fibrinogen concentration on erythrocyte deformability on mobilization of nitric oxide (NO) and of its metabolites in the presence of acetylcholine (ACh) in healthy human blood samples. Acetylcholine 220-223 fibrinogen beta chain Homo sapiens 72-82 22796369-5 2012 KEY FINDINGS: In the presence of high concentrations of fibrinogen and ACh (10 muM) in the blood samples from healthy humans the erythrocyte nitrites, nitrates and GSNO concentrations increased without significant changes in NO efflux. Nitrites 141-149 fibrinogen beta chain Homo sapiens 56-66 22796369-5 2012 KEY FINDINGS: In the presence of high concentrations of fibrinogen and ACh (10 muM) in the blood samples from healthy humans the erythrocyte nitrites, nitrates and GSNO concentrations increased without significant changes in NO efflux. Nitrates 151-159 fibrinogen beta chain Homo sapiens 56-66 22796369-5 2012 KEY FINDINGS: In the presence of high concentrations of fibrinogen and ACh (10 muM) in the blood samples from healthy humans the erythrocyte nitrites, nitrates and GSNO concentrations increased without significant changes in NO efflux. S-Nitrosoglutathione 164-168 fibrinogen beta chain Homo sapiens 56-66 23166957-11 2004 A peptide sequence consisting of Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3. arginyl-glycyl-aspartic acid 33-44 fibrinogen beta chain Homo sapiens 146-156 23130841-6 2012 Plasma levels of thrombin-antithrombin complex, fibrin and/or fibrinogen degradation products and D-dimers decreased after administration of low-molecular-weight heparin. Heparin 162-169 fibrinogen beta chain Homo sapiens 62-72 22820307-3 2012 To regulate the size and distance between patches of fibrinogen we developed a photolithography-based technique to fabricate patterns of proteins surrounded by a protein-repellant layer of poly(ethylene glycol). Polyethylene Glycols 189-210 fibrinogen beta chain Homo sapiens 53-63 22820307-4 2012 We demonstrate that when mepacrine labeled whole blood is perfused at a shear rate of 100 s -1 over substrates patterned with micron-sized wide lines of fibrinogen, platelets selectively adhere to the areas of patterned fibrinogen. Quinacrine 25-34 fibrinogen beta chain Homo sapiens 153-163 22820307-4 2012 We demonstrate that when mepacrine labeled whole blood is perfused at a shear rate of 100 s -1 over substrates patterned with micron-sized wide lines of fibrinogen, platelets selectively adhere to the areas of patterned fibrinogen. Quinacrine 25-34 fibrinogen beta chain Homo sapiens 220-230 23115806-4 2004 The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3. Arginine 21-24 fibrinogen beta chain Homo sapiens 134-144 22989353-7 2012 Atrovastatin treatment showed a reduction in PMNL priming, PMNL apoptosis, fibrinogen and CRP levels concomitant with decreased lipid levels. atrovastatin 0-12 fibrinogen beta chain Homo sapiens 75-85 23115806-4 2004 The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3. Glycine 25-28 fibrinogen beta chain Homo sapiens 134-144 23115806-4 2004 The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3. Aspartic Acid 29-32 fibrinogen beta chain Homo sapiens 134-144 22634603-6 2012 RESULTS: The performed assays demonstrated that Hcy (at high tested concentrations: 50 and 100 muM) and its thiolactone (at all used concentrations: 0.1, 0.2 and 1 muM) stimulated the adhesion of thrombin- or TRAP- activated platelets to collagen and fibrinogen. Thiolactone 108-119 fibrinogen beta chain Homo sapiens 251-261 22705885-6 2012 Culturing the cells in hypertonic solution or in the presence of clathrin inhibitor chlorpromazine abrogated clathrin-dependent endocytosis and diminished the uptake of fibrinogen. Chlorpromazine 84-98 fibrinogen beta chain Homo sapiens 169-179 22634603-0 2012 Changes of blood platelet adhesion to collagen and fibrinogen induced by homocysteine and its thiolactone. Homocysteine 73-85 fibrinogen beta chain Homo sapiens 51-61 22634603-0 2012 Changes of blood platelet adhesion to collagen and fibrinogen induced by homocysteine and its thiolactone. Thiolactone 94-105 fibrinogen beta chain Homo sapiens 51-61 22584076-2 2012 The aim of our in vitro study was to examine the antioxidative properties of grape seed extract, and its potential protective effect on the haemostatic function of human fibrinogen under oxidative stress conditions, induced by peroxynitrite (100 muM). Peroxynitrous Acid 227-240 fibrinogen beta chain Homo sapiens 170-180 23046373-5 2012 Therefore, there has been a growing concern in recent years about patients" low fibrinogen levels due to DFPP treatment. dfpp 105-109 fibrinogen beta chain Homo sapiens 80-90 23093808-0 2012 Formation and cell translocation of carbon nanotube-fibrinogen protein corona. Carbon 36-42 fibrinogen beta chain Homo sapiens 52-62 23093808-1 2012 The binding of plasma fibrinogen with both single-walled and multi-walled carbon nanotubes (SWNTs and MWNTs) has been examined. Carbon 74-80 fibrinogen beta chain Homo sapiens 22-32 22879413-6 2012 RESULTS: SDS-PAGE and Western blot analyses indicated that covalent interactions occurred between neighboring FIB molecules, as well as between FIB and collagen type I (Coll-I) proteins (in vitro and ex vivo). Sodium Dodecyl Sulfate 9-12 fibrinogen beta chain Homo sapiens 110-113 22879413-8 2012 SPR data demonstrated the ability of FIB to bind noncovalently to corneal stroma molecules, Coll-I, decorin, dermatan sulfate, and corneal basement membrane molecules, laminin and heparan sulfate--only in the presence of Zn(2+). Dermatan Sulfate 109-125 fibrinogen beta chain Homo sapiens 37-40 22879413-8 2012 SPR data demonstrated the ability of FIB to bind noncovalently to corneal stroma molecules, Coll-I, decorin, dermatan sulfate, and corneal basement membrane molecules, laminin and heparan sulfate--only in the presence of Zn(2+). Heparitin Sulfate 180-195 fibrinogen beta chain Homo sapiens 37-40 22879413-8 2012 SPR data demonstrated the ability of FIB to bind noncovalently to corneal stroma molecules, Coll-I, decorin, dermatan sulfate, and corneal basement membrane molecules, laminin and heparan sulfate--only in the presence of Zn(2+). Zinc 221-223 fibrinogen beta chain Homo sapiens 37-40 22207707-6 2012 Longitudinal multivariable analyses revealed an inverse association of baseline TT, free T, and DHEAS concentrations with change in fibrinogen levels (per SD decrement in TT, 0.25 [95% confidence interval, 0.04-0.45]; in free T, 0.30 [0.09-0.51]; and in DHEAS, 0.23 [0.11-0.36]). Dehydroepiandrosterone Sulfate 97-102 fibrinogen beta chain Homo sapiens 134-144 22760446-0 2012 Fibrinogen Melbourne: a novel congenital hypodysfibrinogenemia caused by gamma326Cys-Phe in the fibrinogen gamma chain, presenting as massive splanchnic venous thrombosis. gamma326cys 74-85 fibrinogen beta chain Homo sapiens 0-10 22760446-0 2012 Fibrinogen Melbourne: a novel congenital hypodysfibrinogenemia caused by gamma326Cys-Phe in the fibrinogen gamma chain, presenting as massive splanchnic venous thrombosis. gamma326cys 74-85 fibrinogen beta chain Homo sapiens 49-59 22760446-0 2012 Fibrinogen Melbourne: a novel congenital hypodysfibrinogenemia caused by gamma326Cys-Phe in the fibrinogen gamma chain, presenting as massive splanchnic venous thrombosis. Phenylalanine 86-89 fibrinogen beta chain Homo sapiens 0-10 22760446-0 2012 Fibrinogen Melbourne: a novel congenital hypodysfibrinogenemia caused by gamma326Cys-Phe in the fibrinogen gamma chain, presenting as massive splanchnic venous thrombosis. Phenylalanine 86-89 fibrinogen beta chain Homo sapiens 49-59 22760446-3 2012 We describe a novel gamma326Cys Phe mutation in the fibrinogen gamma gene causing hypodysfibrinogenemia associated with life-threatening thrombosis in a family from Melbourne, Australia. gamma326cys 20-31 fibrinogen beta chain Homo sapiens 52-62 22760446-3 2012 We describe a novel gamma326Cys Phe mutation in the fibrinogen gamma gene causing hypodysfibrinogenemia associated with life-threatening thrombosis in a family from Melbourne, Australia. Phenylalanine 32-35 fibrinogen beta chain Homo sapiens 52-62 22207707-6 2012 Longitudinal multivariable analyses revealed an inverse association of baseline TT, free T, and DHEAS concentrations with change in fibrinogen levels (per SD decrement in TT, 0.25 [95% confidence interval, 0.04-0.45]; in free T, 0.30 [0.09-0.51]; and in DHEAS, 0.23 [0.11-0.36]). Dehydroepiandrosterone Sulfate 257-262 fibrinogen beta chain Homo sapiens 134-144 22575419-0 2012 Investigation of the mechanism(s) involved in decreasing increased fibrinogen activity in hyperglycemic conditions using L-lysine supplementation. Lysine 121-129 fibrinogen beta chain Homo sapiens 67-77 22998416-0 2012 Molecular interaction of poly(acrylic acid) gold nanoparticles with human fibrinogen. poly(acrylic acid) gold 25-48 fibrinogen beta chain Homo sapiens 74-84 22998416-3 2012 Here we examine the binding kinetics of human fibrinogen to negatively charged poly(acrylic acid)-coated gold nanoparticles ranging in size from 7 to 22 nm. carbopol 940 79-97 fibrinogen beta chain Homo sapiens 46-56 22349076-3 2012 Niacin also has beneficial effects on other cardiovascular risk factors, including lipoprotein(a), C-reactive protein, platelet-activating factor acetylhydrolase, plasminogen activator inhibitor 1 and fibrinogen. Niacin 0-6 fibrinogen beta chain Homo sapiens 201-211 22575419-3 2012 In this study, the inhibitory effect of L-Lysine (Lys) on the nonenzymatic glycation of fibrinogen was investigated in both in vitro and in vivo conditions. Lysine 40-48 fibrinogen beta chain Homo sapiens 88-98 22575419-3 2012 In this study, the inhibitory effect of L-Lysine (Lys) on the nonenzymatic glycation of fibrinogen was investigated in both in vitro and in vivo conditions. Lysine 42-45 fibrinogen beta chain Homo sapiens 88-98 22575419-4 2012 MATERIALS AND METHODS: Fibrinogen was incubated with glucose in the presence or absence of Lys. Glucose 53-60 fibrinogen beta chain Homo sapiens 23-33 22575419-4 2012 MATERIALS AND METHODS: Fibrinogen was incubated with glucose in the presence or absence of Lys. Lysine 91-94 fibrinogen beta chain Homo sapiens 23-33 22760735-1 2012 Fibrinogen-modified bismuth-gold nanoparticles (Fib-Bi-Au NPs) are prepared and used as enzyme mimics for the H(2)O(2)-mediated reaction with Amplex Red (AR), which is further employed for determining thrombin activity and drug screening. Bismuth 20-27 fibrinogen beta chain Homo sapiens 0-10 22760735-1 2012 Fibrinogen-modified bismuth-gold nanoparticles (Fib-Bi-Au NPs) are prepared and used as enzyme mimics for the H(2)O(2)-mediated reaction with Amplex Red (AR), which is further employed for determining thrombin activity and drug screening. Cephalexin 142-148 fibrinogen beta chain Homo sapiens 0-10 22760735-1 2012 Fibrinogen-modified bismuth-gold nanoparticles (Fib-Bi-Au NPs) are prepared and used as enzyme mimics for the H(2)O(2)-mediated reaction with Amplex Red (AR), which is further employed for determining thrombin activity and drug screening. Amplex Red 154-156 fibrinogen beta chain Homo sapiens 0-10 22521680-5 2012 In protein adsorption experiments, human serum albumin (HSA) and fibrinogen (Fg) were adsorbed on untreated and oxygen plasma treated PET and PP surfaces. Oxygen 112-118 fibrinogen beta chain Homo sapiens 41-75 22503950-5 2012 The biological properties of the polymer were probed by fibrinogen adsorption, human umbilical vein endothelial cell adhesion and growth, and platelet adhesion. Polymers 33-40 fibrinogen beta chain Homo sapiens 56-66 22503950-7 2012 Results were compared to the non-fouling behavior of a PEGylated terpolymer formulation and it was observed that the poly(ethylene glycol)-containing materials were slightly more effective at resisting human umbilical vein endothelial cell adhesion and growth over a 7 day incubation period, but the zwitterion-containing materials were equally effective at resisting fibrinogen adsorption and platelet adhesion. Polyethylene Glycols 117-138 fibrinogen beta chain Homo sapiens 368-378 22852778-3 2012 The purposes of this study were to: 1) analyze the association between chemotherapy-induced changes in plasma fibrinogen level and the chemotherapeutic response after the first two courses of standard first-line platinum-based chemotherapy; and 2) evaluate the prognostic significance of the basal plasma fibrinogen level in patients with advanced NSCLC. Platinum 212-220 fibrinogen beta chain Homo sapiens 110-120 22580301-2 2012 The coagulant protein fibrinogen is posttranslationally modified by nitric oxide-derived oxidants to nitrated fibrinogen in both acute and chronic inflammatory states. Nitric Oxide 68-80 fibrinogen beta chain Homo sapiens 22-32 22626472-2 2012 The purpose of this study was to investigate associations between ten monohydroxy urinary metabolites of four PAHs and three serum biomarkers of cardiovascular disease (fibrinogen, homocysteine, and white blood cell count). Polycyclic Aromatic Hydrocarbons 110-114 fibrinogen beta chain Homo sapiens 169-179 22626472-4 2012 The PAH metabolites of naphthalene, fluorene, phenanthrene, and pyrene each showed both positive and negative correlations with homocysteine, fibrinogen, and white blood cell count (correlation coefficient range: -0.077-0.143) in nonsmoking participants. Polycyclic Aromatic Hydrocarbons 4-7 fibrinogen beta chain Homo sapiens 142-152 22626472-4 2012 The PAH metabolites of naphthalene, fluorene, phenanthrene, and pyrene each showed both positive and negative correlations with homocysteine, fibrinogen, and white blood cell count (correlation coefficient range: -0.077-0.143) in nonsmoking participants. naphthalene 23-34 fibrinogen beta chain Homo sapiens 142-152 22626472-4 2012 The PAH metabolites of naphthalene, fluorene, phenanthrene, and pyrene each showed both positive and negative correlations with homocysteine, fibrinogen, and white blood cell count (correlation coefficient range: -0.077-0.143) in nonsmoking participants. fluorene 36-44 fibrinogen beta chain Homo sapiens 142-152 22626472-4 2012 The PAH metabolites of naphthalene, fluorene, phenanthrene, and pyrene each showed both positive and negative correlations with homocysteine, fibrinogen, and white blood cell count (correlation coefficient range: -0.077-0.143) in nonsmoking participants. phenanthrene 46-58 fibrinogen beta chain Homo sapiens 142-152 22626472-4 2012 The PAH metabolites of naphthalene, fluorene, phenanthrene, and pyrene each showed both positive and negative correlations with homocysteine, fibrinogen, and white blood cell count (correlation coefficient range: -0.077-0.143) in nonsmoking participants. pyrene 64-70 fibrinogen beta chain Homo sapiens 142-152 22836718-0 2012 Reactive carbonyl compounds (RCCs) cause aggregation and dysfunction of fibrinogen. reactive carbonyl compounds 0-27 fibrinogen beta chain Homo sapiens 72-82 22836718-3 2012 Here, we investigated the effect of glycolaldehyde on the activity and deposition of fibrinogen compared with the common RCCs acrolein, methylglyoxal, glyoxal and malondialdehyde. glycolaldehyde 36-50 fibrinogen beta chain Homo sapiens 85-95 22836718-4 2012 At the same concentration (1 mmol/L), glycolaldehyde and acrolein had a stronger suppressive effect on fibrinogen activation than the other three RCCs. glycolaldehyde 38-52 fibrinogen beta chain Homo sapiens 103-113 22836718-4 2012 At the same concentration (1 mmol/L), glycolaldehyde and acrolein had a stronger suppressive effect on fibrinogen activation than the other three RCCs. Acrolein 57-65 fibrinogen beta chain Homo sapiens 103-113 22836718-5 2012 Fibrinogen aggregated when it was respectively incubated with glycolaldehyde and the other RCCs, as demonstrated by SDS-PAGE, electron microscopy and intrinsic fluorescence intensity measurements. glycolaldehyde 62-76 fibrinogen beta chain Homo sapiens 0-10 22836718-5 2012 Fibrinogen aggregated when it was respectively incubated with glycolaldehyde and the other RCCs, as demonstrated by SDS-PAGE, electron microscopy and intrinsic fluorescence intensity measurements. Sodium Dodecyl Sulfate 116-119 fibrinogen beta chain Homo sapiens 0-10 22836718-6 2012 Staining with Congo Red showed that glycolaldehyde- and acrolein-fibrinogen distinctly formed amyloid-like aggregations. Congo Red 14-23 fibrinogen beta chain Homo sapiens 65-75 22836718-9 2012 Taken together, it is glycolaldehyde that suppresses fibrinogenesis and induces protein aggregation most effectively, suggesting a putative pathological process for fibrinogen (fibrin) deposition in the blood. glycolaldehyde 22-36 fibrinogen beta chain Homo sapiens 53-63 22580301-2 2012 The coagulant protein fibrinogen is posttranslationally modified by nitric oxide-derived oxidants to nitrated fibrinogen in both acute and chronic inflammatory states. Nitric Oxide 68-80 fibrinogen beta chain Homo sapiens 110-120 22889519-0 2012 Hydroxyl radical-modified fibrinogen as a marker of thrombosis: the role of iron. Hydroxyl Radical 0-16 fibrinogen beta chain Homo sapiens 26-36 22889519-5 2012 Ferric chloride was also demonstrated to induce aggregation of purified fibrinogen at the same molar concentrations that were used for the generation of hydroxyl radicals. ferric chloride 0-15 fibrinogen beta chain Homo sapiens 72-82 22713578-1 2012 With the use of single-molecule total internal reflection fluorescence microscopy (TIRFM), the dynamics of bovine serum albumin (BSA) and human fibrinogen (Fg) at low concentrations were observed at the solid-aqueous interface as a function of temperature on hydrophobic trimethylsilane (TMS) and hydrophilic fused silica (FS) surfaces. (CH3)3SiH 271-286 fibrinogen beta chain Homo sapiens 156-158 22713578-1 2012 With the use of single-molecule total internal reflection fluorescence microscopy (TIRFM), the dynamics of bovine serum albumin (BSA) and human fibrinogen (Fg) at low concentrations were observed at the solid-aqueous interface as a function of temperature on hydrophobic trimethylsilane (TMS) and hydrophilic fused silica (FS) surfaces. tms 288-291 fibrinogen beta chain Homo sapiens 156-158 22713578-1 2012 With the use of single-molecule total internal reflection fluorescence microscopy (TIRFM), the dynamics of bovine serum albumin (BSA) and human fibrinogen (Fg) at low concentrations were observed at the solid-aqueous interface as a function of temperature on hydrophobic trimethylsilane (TMS) and hydrophilic fused silica (FS) surfaces. Silicon Dioxide 315-321 fibrinogen beta chain Homo sapiens 156-158 22713578-1 2012 With the use of single-molecule total internal reflection fluorescence microscopy (TIRFM), the dynamics of bovine serum albumin (BSA) and human fibrinogen (Fg) at low concentrations were observed at the solid-aqueous interface as a function of temperature on hydrophobic trimethylsilane (TMS) and hydrophilic fused silica (FS) surfaces. phenylalanylserine 323-325 fibrinogen beta chain Homo sapiens 156-158 21872302-0 2012 The procoagulant properties of purified fibrinogen concentrate are enhanced by carbon monoxide releasing molecule-2. Carbon Monoxide 79-94 fibrinogen beta chain Homo sapiens 40-50 21872302-2 2012 We have recently demonstrated that carbon monoxide releasing molecule-2 (tricarbonyldichlororuthenium (II) dimer; CORM-2) enhances fibrinogen as a substrate for thrombin via an attached heme. Carbon Monoxide 35-50 fibrinogen beta chain Homo sapiens 131-141 22649804-19 2004 The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3. Glycine 25-28 fibrinogen beta chain Homo sapiens 134-144 22649804-19 2004 The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3. Aspartic Acid 29-32 fibrinogen beta chain Homo sapiens 134-144 22584083-6 2012 RESULTS: Our data reveal that the synovial fluid of RA patients contains soluble endogenous peptides, derived from fibrinogen, containing significant amounts of citrulline residues and, in some cases, also phosphorylated serine. Citrulline 161-171 fibrinogen beta chain Homo sapiens 115-125 22507986-0 2012 Acetylation and glycation of fibrinogen in vitro occur at specific lysine residues in a concentration dependent manner: a mass spectrometric and isotope labeling study. Lysine 67-73 fibrinogen beta chain Homo sapiens 29-39 22507986-3 2012 We investigated whether acetylation and glycation occur at specific sites in fibrinogen and if competition between glucose and aspirin in binding to fibrinogen occurs. Glucose 115-122 fibrinogen beta chain Homo sapiens 149-159 22507986-3 2012 We investigated whether acetylation and glycation occur at specific sites in fibrinogen and if competition between glucose and aspirin in binding to fibrinogen occurs. Aspirin 127-134 fibrinogen beta chain Homo sapiens 149-159 22507986-5 2012 After incubation of fibrinogen in vitro with aspirin (0.8 mM, 24 h) or glucose (100 mM, 5-10 days), we found 12 modified sites with mass spectrometric techniques. Aspirin 45-52 fibrinogen beta chain Homo sapiens 20-30 22507986-5 2012 After incubation of fibrinogen in vitro with aspirin (0.8 mM, 24 h) or glucose (100 mM, 5-10 days), we found 12 modified sites with mass spectrometric techniques. Glucose 71-78 fibrinogen beta chain Homo sapiens 20-30 22507986-11 2012 Thus, fibrinogen is acetylated at several lysine residues, some of which are involved in the cross-linking of fibrinogen. Lysine 42-48 fibrinogen beta chain Homo sapiens 6-16 22507986-11 2012 Thus, fibrinogen is acetylated at several lysine residues, some of which are involved in the cross-linking of fibrinogen. Lysine 42-48 fibrinogen beta chain Homo sapiens 110-120 22348981-6 2012 One implant in each pair was coated with a thin fibrinogen layer containing 2 bisphosphonates. Diphosphonates 78-93 fibrinogen beta chain Homo sapiens 48-58 22348981-14 2012 In conclusion, a thin, bisphosphonate-eluting fibrinogen coating might improve the fixation of metal implants in human bone. Diphosphonates 23-37 fibrinogen beta chain Homo sapiens 46-56 22348981-14 2012 In conclusion, a thin, bisphosphonate-eluting fibrinogen coating might improve the fixation of metal implants in human bone. Metals 95-100 fibrinogen beta chain Homo sapiens 46-56 22277745-6 2012 The nonspecific adsorption of fibrinogen and lysozyme was measured as a function of the copolymer brush thickness using a surface plasmon resonance biosensor. copolymer 88-97 fibrinogen beta chain Homo sapiens 30-40 22277745-9 2012 The dual functional properties of TMA:CAA copolymers were demonstrated by conjugating fibrinogen to the copolymer brush over a range of brush thicknesses. trimethylamine 34-37 fibrinogen beta chain Homo sapiens 86-96 22277745-9 2012 The dual functional properties of TMA:CAA copolymers were demonstrated by conjugating fibrinogen to the copolymer brush over a range of brush thicknesses. caa copolymers 38-52 fibrinogen beta chain Homo sapiens 86-96 22277745-9 2012 The dual functional properties of TMA:CAA copolymers were demonstrated by conjugating fibrinogen to the copolymer brush over a range of brush thicknesses. copolymer 42-51 fibrinogen beta chain Homo sapiens 86-96 22261575-7 2012 RESULTS: The HTL, like its precursor, Hcys stimulated polymerization of fibrinogen. Homocysteine 38-42 fibrinogen beta chain Homo sapiens 72-82 22607091-5 2012 The antifouling property of pCBMA silica hydrogel to resist protein (fibrinogen) adsorption was measured using enzyme-linked immunosorbent assay (ELISA). Silicon Dioxide 34-40 fibrinogen beta chain Homo sapiens 69-79 22607091-9 2012 A protein adsorption test revealed a reduction in fibrinogen adsorption by 83% at 25 wt % pCBMA content in the hydrogel compared to the fibrinogen adsorption in the unmodified silica hydrogel. polycarboxybetaine methacrylate 90-95 fibrinogen beta chain Homo sapiens 50-60 22442277-7 2012 Although the decrement in highly sensitive C-reactive protein and fibrinogen was more in CDD compared to DD (-4.0 +- 8.5 vs. -1.3 +- 2.8 mg/liter, and -0.40 +- 0.74 and -0.20 +- 0.52 mg/liter, respectively), the differences were not significant. Fumigant 93 90-92 fibrinogen beta chain Homo sapiens 66-76 22551158-1 2012 BACKGROUND: A novel method for the rapid detection of fibrinogen concentration in human plasma, the fibrinogen antigenic turbidimetric assay (FIATA), is based on the precipitation of fibrinogen by vancomycin and a resultant change in optical density. Vancomycin 197-207 fibrinogen beta chain Homo sapiens 54-64 22551158-1 2012 BACKGROUND: A novel method for the rapid detection of fibrinogen concentration in human plasma, the fibrinogen antigenic turbidimetric assay (FIATA), is based on the precipitation of fibrinogen by vancomycin and a resultant change in optical density. Vancomycin 197-207 fibrinogen beta chain Homo sapiens 100-110 22551158-1 2012 BACKGROUND: A novel method for the rapid detection of fibrinogen concentration in human plasma, the fibrinogen antigenic turbidimetric assay (FIATA), is based on the precipitation of fibrinogen by vancomycin and a resultant change in optical density. Vancomycin 197-207 fibrinogen beta chain Homo sapiens 100-110 22551158-6 2012 Fibrinogen concentration was measured in EDTA and heparinized plasma in the manual FIATA. Edetic Acid 41-45 fibrinogen beta chain Homo sapiens 0-10 22551158-12 2012 CONCLUSIONS: The FIATA can be used as a screening method to measure fibrinogen concentration in citrated or EDTA plasma from dogs. Edetic Acid 108-112 fibrinogen beta chain Homo sapiens 68-78 22889519-5 2012 Ferric chloride was also demonstrated to induce aggregation of purified fibrinogen at the same molar concentrations that were used for the generation of hydroxyl radicals. Hydroxyl Radical 154-171 fibrinogen beta chain Homo sapiens 72-82 22889519-6 2012 Iron-aggregated fibrinogen, by contrast to native molecule, could not be dissociated into polypeptide subunit chains as shown in a polyacrylamide gel electrophoresis. Iron 0-4 fibrinogen beta chain Homo sapiens 16-26 22889519-7 2012 The mechanism of this phenomenon is very likely based on hydroxyl radical-induced modification of fibrinogen tertiary structure with the formation of insoluble aggregates resistant to enzymatic and chemical degradations. Hydroxyl Radical 58-74 fibrinogen beta chain Homo sapiens 99-109 22889519-9 2012 In view of these findings, it is postulated that iron-induced alterations in fibrinogen structure is involved in pathogenesis of certain degenerative diseases associated with iron overload and persistent thrombosis. Iron 49-53 fibrinogen beta chain Homo sapiens 77-87 22889519-9 2012 In view of these findings, it is postulated that iron-induced alterations in fibrinogen structure is involved in pathogenesis of certain degenerative diseases associated with iron overload and persistent thrombosis. Iron 175-179 fibrinogen beta chain Homo sapiens 77-87 22889519-10 2012 It is concluded that the detection of hydroxyl radical-modified fibrinogen may be utilized as a marker of a thrombotic condition in human subjects. Hydroxyl Radical 39-55 fibrinogen beta chain Homo sapiens 65-75 22234330-5 2012 Enzyme inhibition by the di-peptydyl substrate impaired the degradation of human fibrinogen at 25 C, but not at 37 C. We also found that heparan sulfate acts as a natural allosteric modulator of the enzyme through interactions that prevent substrate inhibition. Heparitin Sulfate 137-152 fibrinogen beta chain Homo sapiens 81-91 22425273-8 2012 However, increased plasma fibrinogen levels caused underestimation of argatroban levels using the indirect activity-based assay, whereas the UPLC-MS/MS method was unaffected. argatroban 70-80 fibrinogen beta chain Homo sapiens 26-36 22113250-5 2012 RESULTS: Mean fibrinogen levels were lower across the increasing quartiles of the fiber intake after adjusting for age, sex, body mass index, physical activity, smoking status and alcohol consumption, and total calories, percentage of energy intake from carbohydrate, protein and fat, with a difference of 0.08 g/l fibrinogen between first and fourth quartiles (P for trend <0.001) for the whole population. Alcohols 180-187 fibrinogen beta chain Homo sapiens 14-24 22113250-5 2012 RESULTS: Mean fibrinogen levels were lower across the increasing quartiles of the fiber intake after adjusting for age, sex, body mass index, physical activity, smoking status and alcohol consumption, and total calories, percentage of energy intake from carbohydrate, protein and fat, with a difference of 0.08 g/l fibrinogen between first and fourth quartiles (P for trend <0.001) for the whole population. Carbohydrates 254-266 fibrinogen beta chain Homo sapiens 14-24 23543820-0 2012 Silver nano particles prevent platelet adhesion on immobilized fibrinogen. Silver 0-6 fibrinogen beta chain Homo sapiens 63-73 23543820-4 2012 In this study we tried to find out the effect of Silver nanoparticles, through their interaction with various platelet surface integrins on platelet adhesion on immobilized fibrinogen. Silver 49-55 fibrinogen beta chain Homo sapiens 173-183 22249890-11 2012 In contrast, helixone bound only a small proportion of albumin, while proved to be particularly active in retaining protein associated with the coagulation cascade, such as the fibrinogen isoforms. helixone 13-21 fibrinogen beta chain Homo sapiens 177-187 22233480-13 2012 CONCLUSIONS: In CABG patients with bleeding after CPB, FIBTEM-guided administration of fibrinogen concentrate resulted in overall decreased transfusion, compared with haemostatic therapy with allogeneics. fibtem 55-61 fibrinogen beta chain Homo sapiens 87-97 22415575-10 2012 The process takes 2 days to complete, including an overnight dialysis step for the fibrinogen solution to remove citrates that inhibit polymerization. Citrates 113-121 fibrinogen beta chain Homo sapiens 83-93 22112496-0 2012 Fibrinogen and albumin adsorption on titanium nanoroughness gradients. Titanium 37-45 fibrinogen beta chain Homo sapiens 0-10 22649803-19 2004 The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3. Arginine 21-24 fibrinogen beta chain Homo sapiens 134-144 21897424-0 2012 Significant inverse association of marine n-3 fatty acids with plasma fibrinogen levels in Japanese in Japan but not in whites or Japanese Americans. Fatty Acids, Omega-3 42-57 fibrinogen beta chain Homo sapiens 70-80 22649803-19 2004 The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3. Glycine 25-28 fibrinogen beta chain Homo sapiens 134-144 22649803-19 2004 The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3. Aspartic Acid 29-32 fibrinogen beta chain Homo sapiens 134-144 22649804-19 2004 The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3. Arginine 21-24 fibrinogen beta chain Homo sapiens 134-144 22237295-6 2012 RESULTS: We found effects of particle number, black carbon, nitrogen dioxide (NO(2)), and carbon monoxide (CO) on fibrinogen. Carbon 52-58 fibrinogen beta chain Homo sapiens 114-124 22237295-6 2012 RESULTS: We found effects of particle number, black carbon, nitrogen dioxide (NO(2)), and carbon monoxide (CO) on fibrinogen. Nitrogen Dioxide 60-76 fibrinogen beta chain Homo sapiens 114-124 22237295-6 2012 RESULTS: We found effects of particle number, black carbon, nitrogen dioxide (NO(2)), and carbon monoxide (CO) on fibrinogen. Nitrogen Dioxide 78-83 fibrinogen beta chain Homo sapiens 114-124 22237295-6 2012 RESULTS: We found effects of particle number, black carbon, nitrogen dioxide (NO(2)), and carbon monoxide (CO) on fibrinogen. Carbon Monoxide 90-105 fibrinogen beta chain Homo sapiens 114-124 22237295-6 2012 RESULTS: We found effects of particle number, black carbon, nitrogen dioxide (NO(2)), and carbon monoxide (CO) on fibrinogen. Carbon Monoxide 107-109 fibrinogen beta chain Homo sapiens 114-124 21897424-13 2012 The observation suggests that marine n-3 FAs at very high levels, as seen in the Japanese, may decrease plasma fibrinogen levels. ammonium ferrous sulfate 41-44 fibrinogen beta chain Homo sapiens 111-121 22213354-0 2012 Exposure of the lysine in the gamma chain dodecapeptide of human fibrinogen is not enhanced by adsorption to poly(ethylene terephthalate) as measured by biotinylation and mass spectrometry. Lysine 16-22 fibrinogen beta chain Homo sapiens 65-75 22213354-2 2012 To test this hypothesis, mass spectrometric methods were developed to quantify chemical modification of lysine residues following adsorption of fibrinogen to biomaterials. Lysine 104-110 fibrinogen beta chain Homo sapiens 144-154 22213354-5 2012 For the experimental samples, normal human fibrinogen was adsorbed to poly(ethylene terephthalate) (PET) particles. Polyethylene Terephthalates 70-98 fibrinogen beta chain Homo sapiens 43-53 22213354-6 2012 The adsorbed fibrinogen was reacted with NHS-biotin and then eluted from the particles. biotinyl N-hydroxysuccinimide ester 41-51 fibrinogen beta chain Homo sapiens 13-23 22213354-9 2012 Approximately 80% of the GCDP peptides were biotinylated when fibrinogen was reacted with NHS-biotin in solution or adsorbed onto PET. biotinyl N-hydroxysuccinimide ester 90-100 fibrinogen beta chain Homo sapiens 62-72 22319801-15 2004 A tripeptide sequence consisting of Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3. tripeptide K-26 2-12 fibrinogen beta chain Homo sapiens 149-159 21701848-0 2012 Rot and Agr system modulate fibrinogen-binding ability mainly by regulating clfB expression in Staphylococcus aureus NCTC8325. clfb 76-80 fibrinogen beta chain Homo sapiens 28-38 22234385-2 2012 Thus, GPI interfere with interplatelet bridging mediated by fibrinogen. GPI 1046 6-9 fibrinogen beta chain Homo sapiens 60-70 20641959-20 2004 A tripeptide sequence consisting of Arg-Gly-Asp (RGD) is identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins including alphavbeta3. tripeptide K-26 2-12 fibrinogen beta chain Homo sapiens 143-153 20641959-20 2004 A tripeptide sequence consisting of Arg-Gly-Asp (RGD) is identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins including alphavbeta3. Arginine 36-39 fibrinogen beta chain Homo sapiens 143-153 20641959-20 2004 A tripeptide sequence consisting of Arg-Gly-Asp (RGD) is identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins including alphavbeta3. Glycine 40-43 fibrinogen beta chain Homo sapiens 143-153 20641959-20 2004 A tripeptide sequence consisting of Arg-Gly-Asp (RGD) is identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins including alphavbeta3. Aspartic Acid 44-47 fibrinogen beta chain Homo sapiens 143-153 22026755-1 2012 The adsorption of fibrinogen on polystyrene latex particles was studied using the concentration depletion method combined with the AFM detection of residual protein after adsorption. Polystyrenes 32-43 fibrinogen beta chain Homo sapiens 18-28 22026755-8 2012 A monotonic increase in the electrophoretic mobility (zeta potential) of the latex was observed in all cases, indicating a significant adsorption of fibrinogen on latex for pH below 11. Latex 77-82 fibrinogen beta chain Homo sapiens 149-159 22059984-6 2012 The protein-repellent properties of the polySBMA-grafted surface after antibody attachment were evaluated by exposing the surfaces to Alexa Fluor 488-labeled fibrinogen (FIB) solution (0.1 g L(-1)) for 1 h at room temperature. alexa fluor 488 134-149 fibrinogen beta chain Homo sapiens 158-168 22059984-10 2012 Finally, the antibody-coated polySBMA surfaces were exposed to a mixture of Alexa Fluor 647-labeled FIB and Salmonella without the prior use of a blocking solution to evaluate the ability of the surfaces to capture bacteria while simultaneously repelling proteins. Alexa Fluor 647 76-91 fibrinogen beta chain Homo sapiens 100-103 22001751-7 2012 Among the single proteins investigated, fibrinogen showed the strongest affinity for SiO(2), TiO(2) and CB NPs. Silicon Dioxide 85-91 fibrinogen beta chain Homo sapiens 40-50 22001751-7 2012 Among the single proteins investigated, fibrinogen showed the strongest affinity for SiO(2), TiO(2) and CB NPs. titanium dioxide 93-99 fibrinogen beta chain Homo sapiens 40-50 23015827-4 2012 GSF inhibited completely the adhesion of WM-115 cells to the extracellular matrix (ECM) proteins, fibrinogen and fibronectin.In an in vitro angiogenesis assay with human endothelial cells, GSF very effectively inhibited endothelial tubule formation and sprouting of blood vessels, as well as the adhesion of endothelial cells to ECM proteins. GLUTATHIONE SULFINATE 0-3 fibrinogen beta chain Homo sapiens 98-108 22654514-9 2012 MLV-FBN inhibited aggregation induced by arachidonic acid (52.1% +- 8.1% versus 88.0% +- 2.1% in control; P < 0.01) and ristocetin (40.3% +- 8.8% versus 94.3% +- 1.1%; P < 0.005), but it did not modify closure times in PFA-100( ) studies. Arachidonic Acid 41-57 fibrinogen beta chain Homo sapiens 4-7 22654514-9 2012 MLV-FBN inhibited aggregation induced by arachidonic acid (52.1% +- 8.1% versus 88.0% +- 2.1% in control; P < 0.01) and ristocetin (40.3% +- 8.8% versus 94.3% +- 1.1%; P < 0.005), but it did not modify closure times in PFA-100( ) studies. Ristocetin 123-133 fibrinogen beta chain Homo sapiens 4-7 22654514-9 2012 MLV-FBN inhibited aggregation induced by arachidonic acid (52.1% +- 8.1% versus 88.0% +- 2.1% in control; P < 0.01) and ristocetin (40.3% +- 8.8% versus 94.3% +- 1.1%; P < 0.005), but it did not modify closure times in PFA-100( ) studies. Foscarnet 225-228 fibrinogen beta chain Homo sapiens 4-7 22915854-0 2012 Conformational changes of fibrinogen in dispersed carbon nanotubes. Carbon 50-56 fibrinogen beta chain Homo sapiens 26-36 22915854-2 2012 In this study, we identified that the functional intensity of carboxyl groups on carbon nanotubes, which correspond to the water dispersity or hydrophilicity of carbon nanotubes, can induce conformational changes in the fibrinogen domains. Carbon 81-87 fibrinogen beta chain Homo sapiens 220-230 22915854-2 2012 In this study, we identified that the functional intensity of carboxyl groups on carbon nanotubes, which correspond to the water dispersity or hydrophilicity of carbon nanotubes, can induce conformational changes in the fibrinogen domains. Water 123-128 fibrinogen beta chain Homo sapiens 220-230 22915854-2 2012 In this study, we identified that the functional intensity of carboxyl groups on carbon nanotubes, which correspond to the water dispersity or hydrophilicity of carbon nanotubes, can induce conformational changes in the fibrinogen domains. Carbon 161-167 fibrinogen beta chain Homo sapiens 220-230 22915854-3 2012 Also, elevation of carbon nanotube density can alter the secondary structures (ie, helices and beta sheets) of fibrinogen. Carbon 19-25 fibrinogen beta chain Homo sapiens 111-121 22915854-4 2012 Furthermore, fibrinogen that had been in contact with the nanoparticle material demonstrated a different pattern of heat denaturation compared with free fibrinogen as a result of a variation in hydrophilicity and concentration of carbon nanotubes. Carbon 230-236 fibrinogen beta chain Homo sapiens 13-23 22915854-5 2012 Considering the importance of interactions between carbon nanotubes and plasma proteins in the drug delivery system, this study elucidated the correlation between nanoscale physiochemical material properties of carbon nanotubes and associated structural changes in fibrinogen. Carbon 211-217 fibrinogen beta chain Homo sapiens 265-275 22419873-1 2012 Novel tissue-engineered magnetic fibrin hydrogel scaffolds were prepared by the interaction of thrombin-conjugated iron oxide magnetic nanoparticles with fibrinogen. ferric oxide 115-125 fibrinogen beta chain Homo sapiens 154-164 22090363-7 2012 It was concluded that oral losmapimod significantly reduced plasma fibrinogen in patients with COPD. 6-(5-((cyclopropylamino)carbonyl)-3-fluoro-2-methylphenyl)-N-(2,2-dimethylprpyl)-3-pyridinecarboxamide 27-37 fibrinogen beta chain Homo sapiens 67-77 22740939-0 2012 Chemically modified heparins inhibit fibrinogen-bridged indirect adhesion between tumor cells and platelets. Heparin 20-28 fibrinogen beta chain Homo sapiens 37-47 22740939-3 2012 In the present study, we aimed to detect the effects of 8 chemically modified heparins on the binding of fibrinogen to platelets or tumor cells using flow cytometry assays, as well as the fibrinogen-bridged adhesion of platelets and tumor cells using flow chamber assays. Heparin 78-86 fibrinogen beta chain Homo sapiens 105-115 22740939-6 2012 These data indicate that chemically modified heparins should be potential inhibitors for the fibrinogen-bridged indirect adhesion of platelets and tumor cells, which provides a novel explanation of the anti-adhesion property of heparin and proposes a new anti-metastatic target for cancer treatment. Heparin 45-53 fibrinogen beta chain Homo sapiens 93-103 22740939-6 2012 These data indicate that chemically modified heparins should be potential inhibitors for the fibrinogen-bridged indirect adhesion of platelets and tumor cells, which provides a novel explanation of the anti-adhesion property of heparin and proposes a new anti-metastatic target for cancer treatment. Heparin 45-52 fibrinogen beta chain Homo sapiens 93-103 22463096-8 2012 Thalidomide therapy (100 mg/day) provided reduction in the median D-dimer levels to 6.07 (4.71-10.21) mug/ml and increase in median fibrinogen concentration to 1.9 g/L; soluble fibrin monomers were unidentifiable. Thalidomide 0-11 fibrinogen beta chain Homo sapiens 132-142 22577622-4 2012 Possible interactions of homocysteine and its different derivatives, including homocysteine thiolactone, with the major components of hemostasis such as endothelial cells, blood platelets, plasmatic fibrinogen and plasminogen, are also discussed. Homocysteine 25-37 fibrinogen beta chain Homo sapiens 199-209 22240357-1 2012 Recent evidence has shown that plasma fibrinogen, a major cardiovascular risk factor, interacts with the erythrocyte membrane and acts to influence blood flow via erythrocyte nitric oxide (NO) modulation. Nitric Oxide 175-187 fibrinogen beta chain Homo sapiens 38-48 22240385-6 2012 However, the high concentration of fibrinogen caused electrical saturation, which resulted in different results of CSS determined from between LB and EC. thiocysteine 115-118 fibrinogen beta chain Homo sapiens 35-45 22505888-12 2012 Whereas total cholesterol, homocysteine, and LDL were correlated with CAIMT, hs-CRP, PAI-1, and fibrinogen were not. Cholesterol 14-25 fibrinogen beta chain Homo sapiens 96-106 22120019-6 2012 Using optical tweezers-based force spectroscopy to measure non-specific protein-protein interactions, we found the dextran-coated beads nonreactive towards fibrinogen, thus providing an inert platform for biospecific modifications. Dextrans 115-122 fibrinogen beta chain Homo sapiens 156-166 22319801-15 2004 A tripeptide sequence consisting of Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3. Arginine 36-39 fibrinogen beta chain Homo sapiens 149-159 22319801-15 2004 A tripeptide sequence consisting of Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3. glycylaspartic acid 40-47 fibrinogen beta chain Homo sapiens 149-159 23087151-4 2012 The potency of respective compound to inhibit platelet adhesion to both collagen and fibrinogen surfaces was in the following order; citalopram > sertraline > reboxetine. Citalopram 133-143 fibrinogen beta chain Homo sapiens 85-95 23187627-5 2012 Fibrinogen leakage correlates with areas of axonal damage and induces reactive oxygen species release in microglia. Reactive Oxygen Species 70-93 fibrinogen beta chain Homo sapiens 0-10 23087151-4 2012 The potency of respective compound to inhibit platelet adhesion to both collagen and fibrinogen surfaces was in the following order; citalopram > sertraline > reboxetine. Sertraline 149-159 fibrinogen beta chain Homo sapiens 85-95 23087151-4 2012 The potency of respective compound to inhibit platelet adhesion to both collagen and fibrinogen surfaces was in the following order; citalopram > sertraline > reboxetine. Reboxetine 165-175 fibrinogen beta chain Homo sapiens 85-95 23087151-5 2012 In contrast, venlafaxine caused a weak but statistically significant increased platelet adhesion to fibrinogen. Venlafaxine Hydrochloride 13-24 fibrinogen beta chain Homo sapiens 100-110 22010991-0 2012 Homocysteine and its thiolactone-mediated modification of fibrinogen affect blood platelet adhesion. Thiolactone 21-32 fibrinogen beta chain Homo sapiens 58-68 22010991-5 2012 The aim of this study was to establish the functional changes of the fibrinogen molecule induced by Hcys (at final doses of 10-100 microM) and the most reactive form of Hcys - its cyclic thioester, homocysteine thiolactone (0.1-1 microM), and to examine the effects of these changes on the capability of fibrinogen to interact with human blood platelets (by measuring the platelet adhesion). Thiolactone 211-222 fibrinogen beta chain Homo sapiens 69-79 23087151-6 2012 CONCLUSION: This study showed that sertraline, citalopram and reboxetine direct and acutely decrease platelet adhesion to both collagen and fibrinogen in vitro. Sertraline 35-45 fibrinogen beta chain Homo sapiens 140-150 22010991-6 2012 Our present results demonstrated that Hcys-treated fibrinogen in comparison with native molecule had a distinct capability to mediate platelet adhesion. Homocysteine 38-42 fibrinogen beta chain Homo sapiens 51-61 23087151-6 2012 CONCLUSION: This study showed that sertraline, citalopram and reboxetine direct and acutely decrease platelet adhesion to both collagen and fibrinogen in vitro. Citalopram 47-57 fibrinogen beta chain Homo sapiens 140-150 22010991-7 2012 Both, unstimulated and thrombin-activated platelets showed a reduced ability to adhere to Hcys-mediated fibrinogen. Homocysteine 90-94 fibrinogen beta chain Homo sapiens 104-114 23087151-6 2012 CONCLUSION: This study showed that sertraline, citalopram and reboxetine direct and acutely decrease platelet adhesion to both collagen and fibrinogen in vitro. Reboxetine 62-72 fibrinogen beta chain Homo sapiens 140-150 23421038-5 2012 The aim of the study was to assess fibrinogen changes after alcohol drinking cessation among cigarette smokers and non-smokers. Alcohols 60-67 fibrinogen beta chain Homo sapiens 35-45 22761953-9 2012 Rosiglitazone, AS601245 and combined treatment down-regulated the expression of fibrinogen chains in all three cell lines. Rosiglitazone 0-13 fibrinogen beta chain Homo sapiens 80-90 22761953-9 2012 Rosiglitazone, AS601245 and combined treatment down-regulated the expression of fibrinogen chains in all three cell lines. 1,3-benzothiazol-2-yl(2-((2-(3-pyridinyl)ethyl)amino)-4-pyrimidinyl)acetonitrile 15-23 fibrinogen beta chain Homo sapiens 80-90 22761953-10 2012 Moreover, rosiglitazone, alone or in association with AS601245, caused a decrease in the fibrinogen release. Rosiglitazone 10-23 fibrinogen beta chain Homo sapiens 89-99 22761953-10 2012 Moreover, rosiglitazone, alone or in association with AS601245, caused a decrease in the fibrinogen release. 1,3-benzothiazol-2-yl(2-((2-(3-pyridinyl)ethyl)amino)-4-pyrimidinyl)acetonitrile 54-62 fibrinogen beta chain Homo sapiens 89-99 22273510-13 2012 In contrast, by the addition of tPA, both fibrinogen and FXIII separately and, to more extent, in combination enhanced clot quality as well as resistance against tPA-induced fibrinolysis (increasing MCF, AUC, and lysis onset time). Tetradecanoylphorbol Acetate 32-35 fibrinogen beta chain Homo sapiens 42-52 22273510-13 2012 In contrast, by the addition of tPA, both fibrinogen and FXIII separately and, to more extent, in combination enhanced clot quality as well as resistance against tPA-induced fibrinolysis (increasing MCF, AUC, and lysis onset time). Tetradecanoylphorbol Acetate 162-165 fibrinogen beta chain Homo sapiens 42-52 23421038-10 2012 Among smoking patients fibrinogen levels increased after three weeks post alcohol cessation by 7.9% (z 3.41 do 3.68 g/l) and went back to a baseline level of 3.50 g/l. Alcohols 74-81 fibrinogen beta chain Homo sapiens 23-33 23421038-12 2012 We found that alcohol cessation leads to decrease of fibrinogen levels only among non-smoking patients post alcohol cessation. Alcohols 14-21 fibrinogen beta chain Homo sapiens 53-63 23421038-12 2012 We found that alcohol cessation leads to decrease of fibrinogen levels only among non-smoking patients post alcohol cessation. Alcohols 108-115 fibrinogen beta chain Homo sapiens 53-63 22395372-8 2012 In multivariate regression analysis, only fibrinogen level (OR=1.063, p=0.010) and pulse pressure (OR=1.197, p=0.023) were found to be independent indicators of aspirin resistance and PAI. Aspirin 161-168 fibrinogen beta chain Homo sapiens 42-52 22395372-9 2012 In ROC analysis, cut-off values of 50 mmHg for pulse pressure and 400 mg/dl for fibrinogen level predicted aspirin resistance with 88.9% and 74% sensitivity and 64.4% and 68% specificity, respectively. Aspirin 107-114 fibrinogen beta chain Homo sapiens 80-90 22395372-10 2012 CONCLUSION: Our findings suggest that measurements of fibrinogen level and pulse pressure may be used as easy and reliable methods in predicting aspirin resistance. Aspirin 145-152 fibrinogen beta chain Homo sapiens 54-64 20641531-7 2004 A tripeptide sequence consisting of Arg-Gly-Asp (RGD) is identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins including alphavbeta3. tripeptide K-26 2-12 fibrinogen beta chain Homo sapiens 143-153 23654149-3 2012 Additional use of atorvastatin to a conventional therapy leads to significant reduction of C-reactive protein and fibrinogen and improves effect of long-term sinus rhythm maintenance. Atorvastatin 18-30 fibrinogen beta chain Homo sapiens 114-124 22077421-0 2011 Surface modification with poly(sulfobetaine methacrylate-co-acrylic acid) to reduce fibrinogen adsorption, platelet adhesion, and plasma coagulation. poly(sulfobetaine methacrylate-co-acrylic acid 26-72 fibrinogen beta chain Homo sapiens 84-94 21785328-5 2011 An erroneous diagnosis of lichen planus based on the presence of conjunctival subepithelial fibrinogen can initiate prolonged treatment with topical steroids leading to avoidable, blinding, complication, and further, delay therapy for the real cause of the conjunctivitis. Steroids 149-157 fibrinogen beta chain Homo sapiens 92-102 21315618-7 2011 MEASUREMENTS AND MAIN RESULTS: The present results show that the prothrombin time (PT) and fibrinogen measurements are altered significantly by heparin concentrations above 2 IU/mL. Heparin 144-151 fibrinogen beta chain Homo sapiens 91-101 21315618-18 2011 In particular, fibrinogen values are falsely low at heparin levels of 2 IU/mL and above. Heparin 52-59 fibrinogen beta chain Homo sapiens 15-25 22010909-6 2011 AHRPam was much less effective in countering inhibition by the GPRPGGGGCam-albumin conjugate, suggesting that the observed effects with this conjugate involve mainly the gammaC holes of fibrin/fibrinogen. ahrpam 0-6 fibrinogen beta chain Homo sapiens 193-203 21940635-6 2011 Furthermore, we found that Rap1b was activated by platelet spreading on immobilized fibrinogen, a process that was not affected by P2Y(12) or TXA(2) receptor deficiency, but was inhibited by the selective Src inhibitor PP2, the PKC inhibitor Ro-31-8220, or the calcium chelator demethyl-1,2-bis(2-aminophenoxy)ethane-N,N,N",N"-tetraacetic acid tetrakis. Ro 31-8220 242-252 fibrinogen beta chain Homo sapiens 84-94 21940635-6 2011 Furthermore, we found that Rap1b was activated by platelet spreading on immobilized fibrinogen, a process that was not affected by P2Y(12) or TXA(2) receptor deficiency, but was inhibited by the selective Src inhibitor PP2, the PKC inhibitor Ro-31-8220, or the calcium chelator demethyl-1,2-bis(2-aminophenoxy)ethane-N,N,N",N"-tetraacetic acid tetrakis. demethyl-1,2-bis(2-aminophenoxy)ethane-n,n,n",n"-tetraacetic acid tetrakis 278-352 fibrinogen beta chain Homo sapiens 84-94 21742756-3 2011 The study assessed the effects of heparin-coated CPB systems on the level and function of fibrinogen as measured by thromboelastography (TEG), as compared with non-coated systems. Heparin 34-41 fibrinogen beta chain Homo sapiens 90-100 21867445-7 2011 Nonetheless, a significant improvement in the Disease Activity Score (DAS) and a reduction in fibrinogen level was observed at 6 and 12 months compared with baseline in the rosuvastatin group. Rosuvastatin Calcium 173-185 fibrinogen beta chain Homo sapiens 94-104 21867445-9 2011 CONCLUSION: Our data suggest that rosuvastatin has a modest anti-inflammatory effect in RA patients with low disease activity in terms of reduction in DAS and fibrinogen level. Rosuvastatin Calcium 34-46 fibrinogen beta chain Homo sapiens 159-169 21932842-6 2011 Plasmin digests of HC fibrinogen produced fragments that were similar to normal D and E; further, as with normal fibrinogen, the knob "A" peptide, GPRP, reversed the plasmin cleavage associated with addition of EDTA. Edetic Acid 211-215 fibrinogen beta chain Homo sapiens 22-32 21932842-9 2011 To determine whether HC and normal fibrinogen could form a copolymer, we examined mixtures of these. copolymer 59-68 fibrinogen beta chain Homo sapiens 35-45 21820893-10 2011 The SPR biosensor has a sensitivity of 42 mDeg/(mg/mL) for a fibrinogen concentration in the range of 0.5-2.5 mg/mL, whereas it was hard to correlate the measurements to the spiked-fibrinogen samples of above 2.5 mg/mL. mdeg 42-46 fibrinogen beta chain Homo sapiens 61-71 21621181-7 2011 Results are discussed, obtained for cationic polyelectrolytes (PEI, PAH) and fibrinogen adsorbing on mica, interpreted quantitatively in terms of the theoretical approach postulating a heterogeneous 3D charge distribution. mica 101-105 fibrinogen beta chain Homo sapiens 77-87 21757036-3 2011 This study focuses on the interactions between fibrinogen and sol-gel glass particles of the 70S30C (70 mol.% SiO(2), 30 mol.% CaO composition). silicon monoxide 110-113 fibrinogen beta chain Homo sapiens 47-57 21757036-3 2011 This study focuses on the interactions between fibrinogen and sol-gel glass particles of the 70S30C (70 mol.% SiO(2), 30 mol.% CaO composition). lime 127-130 fibrinogen beta chain Homo sapiens 47-57 21757036-9 2011 The surface properties of the glasses, which can be modulated by media pH, glass composition and final stabilisation temperature in the sol-gel process, have effects on fibrinogen adsorption via long-range Coulombic forces before the adsorption and via short-range interactions such as hydrogen bonding after the adsorption. Hydrogen 286-294 fibrinogen beta chain Homo sapiens 169-179 21737785-8 2011 CONCLUSIONS: RBCs confer lytic resistance to fibrin resulting from modified fibrin structure and impaired plasminogen activation through a mechanism that involves eptifibatide-sensitive fibrinogen-RBC interactions. Eptifibatide 163-175 fibrinogen beta chain Homo sapiens 186-196 21757653-10 2011 These findings contrast those for total fibrinogen levels, which are associated with different genetic loci, particularly FGB, which encodes the Bbeta chain. bbeta 145-150 fibrinogen beta chain Homo sapiens 40-50 21757653-10 2011 These findings contrast those for total fibrinogen levels, which are associated with different genetic loci, particularly FGB, which encodes the Bbeta chain. bbeta 145-150 fibrinogen beta chain Homo sapiens 122-125 22279244-1 2011 Competitive adsorption of three human plasma proteins: albumin (HSA), fibrinogen (Fgn), and immunoglobulin G (IgG) from their ternary solution mixtures onto a sulfhydryl-to-sulfonate gradient surface was investigated using spatially-resolved total internal reflection fluorescence (TIRF) and autoradiography. Sulfhydryl Compounds 159-170 fibrinogen beta chain Homo sapiens 82-85 21942978-1 2011 Evicel is a fibrin sealant consisting of two components, human clottable protein (predominantly human fibrinogen) and human thrombin. evicel 0-6 fibrinogen beta chain Homo sapiens 103-113 21942978-4 2011 Evicel differs from Quixil /Crosseal in that its fibrinogen component does not contain the antifibrinolytic agent tranexamic acid, which is potentially neurotoxic, resulting in Quixil /Crosseal being contraindicated for use in neurosurgery. evicel 0-6 fibrinogen beta chain Homo sapiens 51-61 21942979-3 2011 Fenofibrate also has nonlipid, pleiotropic effects (e.g. reducing levels of fibrinogen, C-reactive protein and various pro-inflammatory markers, and improving flow-mediated dilatation) that may contribute to its clinical efficacy, particularly in terms of improving microvascular outcomes. Fenofibrate 0-11 fibrinogen beta chain Homo sapiens 76-86 21740311-6 2011 It was also demonstrated that oxidized fibrinogen is bound to apolipoprotein(a) of lipoprotein(a) via lysine binding sites. Lysine 102-108 fibrinogen beta chain Homo sapiens 39-49 24331137-4 2011 RESULTS: Fenofibrate significantly decreased systolic blood pressure, pulse wave velocity, serum insulin, insulin resistance (calculated from the homeostasis model assessment), total cholesterol, triglyceride, remnant-like particles cholesterol, uric acid, D-dimer, fibrinogen, serum amyloid A/low-density lipoprotein (LDL) and apoA1/LDL levels. Fenofibrate 9-20 fibrinogen beta chain Homo sapiens 266-276 20641531-7 2004 A tripeptide sequence consisting of Arg-Gly-Asp (RGD) is identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins including alphavbeta3. Arginine 36-39 fibrinogen beta chain Homo sapiens 143-153 20641531-7 2004 A tripeptide sequence consisting of Arg-Gly-Asp (RGD) is identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins including alphavbeta3. Glycine 40-43 fibrinogen beta chain Homo sapiens 143-153 20641531-7 2004 A tripeptide sequence consisting of Arg-Gly-Asp (RGD) is identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins including alphavbeta3. Aspartic Acid 44-47 fibrinogen beta chain Homo sapiens 143-153 21929771-11 2011 The parameters of infection including, fibrinogen (p = 0.03), white blood cell count (p = 0.001) and C-reactive protein (p = 0.0001) were significantly reduced after daptomycin application. Daptomycin 166-176 fibrinogen beta chain Homo sapiens 39-49 21766803-3 2011 In this work, we measure the effects of solution concentration, residence time, and protein competition with BSA on the time-dependent functional changes in adsorbed fibrinogen on mica surface. mica 180-184 fibrinogen beta chain Homo sapiens 166-176 21757718-1 2011 Histidine-rich glycoprotein (HRG) is an abundant protein that binds fibrinogen and other plasma proteins in a Zn(2+)-dependent fashion but whose function is unclear. Zinc 110-112 fibrinogen beta chain Homo sapiens 68-78 21757718-4 2011 By immunoassay, HRG-fibrinogen complexes were detected in Zn(2+)-supplemented human plasma, a finding consistent with a high affinity interaction. Zinc 58-64 fibrinogen beta chain Homo sapiens 20-30 21601209-9 2011 Quercetin did not affect atherogenic plasma lipids or lipoproteins but it significantly lowered the circulating inflammatory risk factors SAA and fibrinogen. Quercetin 0-9 fibrinogen beta chain Homo sapiens 146-156 21601209-12 2011 CONCLUSION: Quercetin reduces the expression of human CRP and cardiovascular risk factors (SAA, fibrinogen) in mice in vivo. Quercetin 12-21 fibrinogen beta chain Homo sapiens 96-106 21895550-6 2011 Fibrinogen adsorption (37 C for 90 min) decreased by 98% to 87% compared to that on ordinary polyurethane surfaces, and almost no platelet adhesion and activation was observed at 37 C for 2 h. Polyurethanes 93-105 fibrinogen beta chain Homo sapiens 0-10 21519232-6 2011 We found positive correlations in the NAU: TAFI and fibrinogen (r=0.65, P=0.02), PAI-1 and triglycerides (r=0.67, P=0.01), in the MAU: TAFI and F1+2 (r=0.48, P=0.02), TAFI and systolic blood pressure (r=0.53, P=0.01), PAI-1 and BMI (r=0.43, P<0.05). NAU 38-41 fibrinogen beta chain Homo sapiens 52-62 21801056-5 2011 RESULTS: Coated platelets were identified on the basis of expression of alpha-granule fibrinogen and were generated in response to stimulation with the thrombin-convulxin combination but not to stimulation with either agonist alone. thrombin-convulxin 152-170 fibrinogen beta chain Homo sapiens 86-96 21729238-7 2011 After levothyroxine 0.45 or 0.6 mg per day, levels of fibrinogen increased by 17%, VWF activity by 24%, VWF antigen by 26%, FVIII by 19%, FIX by 14%, FX by 7%, PAI-1 by 116% and clot-lysis time by 14%, and activated partial thromboplastin time decreased by 3%; all were significant changes compared with the control situation. Thyroxine 6-19 fibrinogen beta chain Homo sapiens 54-64 21725578-0 2011 Two different fibrinogen gene mutations associated with bleeding in the same family (A alphaGly13Glu and gammaGly16Ser) and their impact on fibrin clot properties: fibrinogen Krakow II and Krakow III. alphagly13glu 87-100 fibrinogen beta chain Homo sapiens 14-24 21725578-0 2011 Two different fibrinogen gene mutations associated with bleeding in the same family (A alphaGly13Glu and gammaGly16Ser) and their impact on fibrin clot properties: fibrinogen Krakow II and Krakow III. gammagly16ser 105-118 fibrinogen beta chain Homo sapiens 14-24 21675801-2 2011 Fenofibrate also has a number of nonlipid, pleiotropic effects (e.g. reducing levels of fibrinogen, C-reactive protein, and various pro-inflammatory markers, and improving flow-mediated dilatation) that may contribute to its clinical efficacy, particularly in terms of improving microvascular outcomes. Fenofibrate 0-11 fibrinogen beta chain Homo sapiens 88-98 21536417-5 2011 It was found that the adsorption amount of fibrinogen on the polypeptide-coated surface depended on the dose of the polypeptide on silicon wafer. silicon wafer 131-144 fibrinogen beta chain Homo sapiens 43-53 21529934-1 2011 Platelet adhesion to adsorbed plasma proteins, such as fibrinogen (Fg), has been conventionally thought to be mediated by the GPIIb/IIIa receptor binding to Arg-Gly-Asp (RGD)-like motifs in the adsorbed protein. Arginine 157-160 fibrinogen beta chain Homo sapiens 55-65 21529934-1 2011 Platelet adhesion to adsorbed plasma proteins, such as fibrinogen (Fg), has been conventionally thought to be mediated by the GPIIb/IIIa receptor binding to Arg-Gly-Asp (RGD)-like motifs in the adsorbed protein. Glycine 161-164 fibrinogen beta chain Homo sapiens 55-65 21529934-1 2011 Platelet adhesion to adsorbed plasma proteins, such as fibrinogen (Fg), has been conventionally thought to be mediated by the GPIIb/IIIa receptor binding to Arg-Gly-Asp (RGD)-like motifs in the adsorbed protein. Aspartic Acid 165-168 fibrinogen beta chain Homo sapiens 55-65 21459789-0 2011 The natural occurrence of human fibrinogen variants disrupting inter-chain disulfide bonds (A{alpha}Cys36Gly, A{alpha}Cys36Arg and A{alpha}Cys45Tyr) confirms the role of N-terminal A{alpha} disulfide bonds in protein assembly and secretion. Disulfides 75-84 fibrinogen beta chain Homo sapiens 32-42 21459789-0 2011 The natural occurrence of human fibrinogen variants disrupting inter-chain disulfide bonds (A{alpha}Cys36Gly, A{alpha}Cys36Arg and A{alpha}Cys45Tyr) confirms the role of N-terminal A{alpha} disulfide bonds in protein assembly and secretion. Disulfides 190-199 fibrinogen beta chain Homo sapiens 32-42 21459789-1 2011 Analyses of site-directed fibrinogen mutants expressed in several recombinant models have previously shown that both inter- and intra-chain disulfide bonds are critical for fibrinogen assembly and secretion. Disulfides 140-149 fibrinogen beta chain Homo sapiens 26-36 21459789-1 2011 Analyses of site-directed fibrinogen mutants expressed in several recombinant models have previously shown that both inter- and intra-chain disulfide bonds are critical for fibrinogen assembly and secretion. Disulfides 140-149 fibrinogen beta chain Homo sapiens 173-183 21459789-3 2011 This confirms the main role of the AalphaCys36-BbetaCys65 and AalphaCys45-gammaCys23 disulfide bonds in reaching a normal fibrinogen plasma level. Disulfides 85-94 fibrinogen beta chain Homo sapiens 122-132 21605328-0 2011 Epigenetic, polymorphic and mutational (Alphaalpha167Arg Lys) contribution to a functionally abnormal fibrinogen. Lysine 57-60 fibrinogen beta chain Homo sapiens 102-112 20861868-5 2011 These findings add evidence concerning an age-modulated relationship between the levels of uric acid and fibrinogen and the steady and pulsatile components of BP and it is possibly related to the different mechanisms underlying increased BP: renal factors in middle-aged subjects and vascular abnormalities in the elderly. Uric Acid 91-100 fibrinogen beta chain Homo sapiens 105-115 21435714-3 2011 We propose the use of polyethylene glycol (PEG)-based linkers that interact with fibrinogen via knob:hole affinity interactions as a means of controlling thrombin-mediated fibrin polymerization dynamics and resulting network structure. Polyethylene Glycols 22-41 fibrinogen beta chain Homo sapiens 81-91 21435714-3 2011 We propose the use of polyethylene glycol (PEG)-based linkers that interact with fibrinogen via knob:hole affinity interactions as a means of controlling thrombin-mediated fibrin polymerization dynamics and resulting network structure. Polyethylene Glycols 43-46 fibrinogen beta chain Homo sapiens 81-91 21435714-4 2011 Using bivalent and tetravalent knob-PEG conjugates with sizes ranging from 2 to 20 kDa, we demonstrate that the clotting characteristics of fibrinogen solutions can be altered in a dose-dependent manner, with conjugate size playing a major role in altering fibrin network structure. Polyethylene Glycols 36-39 fibrinogen beta chain Homo sapiens 140-150 21451399-0 2011 Fibrinogen is a heme-associated, carbon monoxide sensing molecule: a preliminary report. Carbon Monoxide 33-48 fibrinogen beta chain Homo sapiens 0-10 21451399-1 2011 The objective of this study was to determine how carbon monoxide directly modifies fibrinogen utilizing liquid chromatography-mass spectrometry (LC-MS/MS) by examining fibrinogen exposed to carbon monoxide releasing molecule-2 [tricarbonyldichlororuthenium (II) dimer; CORM-2]. Carbon Monoxide 49-64 fibrinogen beta chain Homo sapiens 83-93 21451399-1 2011 The objective of this study was to determine how carbon monoxide directly modifies fibrinogen utilizing liquid chromatography-mass spectrometry (LC-MS/MS) by examining fibrinogen exposed to carbon monoxide releasing molecule-2 [tricarbonyldichlororuthenium (II) dimer; CORM-2]. Carbon Monoxide 49-64 fibrinogen beta chain Homo sapiens 168-178 21451399-1 2011 The objective of this study was to determine how carbon monoxide directly modifies fibrinogen utilizing liquid chromatography-mass spectrometry (LC-MS/MS) by examining fibrinogen exposed to carbon monoxide releasing molecule-2 [tricarbonyldichlororuthenium (II) dimer; CORM-2]. Carbon Monoxide 190-205 fibrinogen beta chain Homo sapiens 83-93 21451399-1 2011 The objective of this study was to determine how carbon monoxide directly modifies fibrinogen utilizing liquid chromatography-mass spectrometry (LC-MS/MS) by examining fibrinogen exposed to carbon monoxide releasing molecule-2 [tricarbonyldichlororuthenium (II) dimer; CORM-2]. Carbon Monoxide 190-205 fibrinogen beta chain Homo sapiens 168-178 21451399-8 2011 Carbon monoxide derived from CORM-2 likely modifies fibrinogen via modulation of a fibrinogen-associated heme group(s). Carbon Monoxide 0-15 fibrinogen beta chain Homo sapiens 52-62 21451399-8 2011 Carbon monoxide derived from CORM-2 likely modifies fibrinogen via modulation of a fibrinogen-associated heme group(s). Carbon Monoxide 0-15 fibrinogen beta chain Homo sapiens 83-93 21451399-8 2011 Carbon monoxide derived from CORM-2 likely modifies fibrinogen via modulation of a fibrinogen-associated heme group(s). Heme 105-109 fibrinogen beta chain Homo sapiens 52-62 21451399-8 2011 Carbon monoxide derived from CORM-2 likely modifies fibrinogen via modulation of a fibrinogen-associated heme group(s). Heme 105-109 fibrinogen beta chain Homo sapiens 83-93 21451399-9 2011 Whereas the precise molecular location of heme attachment and three-dimensional conformational change secondary to carbon monoxide exposure remain to be determined, fibrinogen appears to be a carbon monoxide sensing molecule. Carbon Monoxide 192-207 fibrinogen beta chain Homo sapiens 165-175 21656984-21 2004 A tripeptide sequence comprising Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins including alphavbeta3. tripeptide K-26 2-12 fibrinogen beta chain Homo sapiens 146-156 21656984-21 2004 A tripeptide sequence comprising Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins including alphavbeta3. arginyl-glycyl-aspartic acid 33-44 fibrinogen beta chain Homo sapiens 146-156 20530059-4 2011 The lysis rate was changed according to oxidation time between Fg exposed to Fe(3+)/ascorbate and control exposed to Fe( 3+)/ascorbate for the same treatment time (1.9 +- 0.71 vs 7 +- 0.5, 1.6 +- 0.1, 1.2 +- 0.5, 0.9 +- 1.3, P < .001). ferric sulfate 77-83 fibrinogen beta chain Homo sapiens 63-65 20530059-4 2011 The lysis rate was changed according to oxidation time between Fg exposed to Fe(3+)/ascorbate and control exposed to Fe( 3+)/ascorbate for the same treatment time (1.9 +- 0.71 vs 7 +- 0.5, 1.6 +- 0.1, 1.2 +- 0.5, 0.9 +- 1.3, P < .001). Ascorbic Acid 84-93 fibrinogen beta chain Homo sapiens 63-65 21460246-4 2011 We show that host fibrinogen (FG) was constantly present (at ~ 1 FG per 25 000 HZ-heme molecules) and stably bound to nHZ from plasma-cultured parasites. Heme 82-86 fibrinogen beta chain Homo sapiens 18-28 21440897-0 2011 Detection of nisin and fibrinogen adsorption on poly(ethylene oxide) coated polyurethane surfaces by time-of-flight secondary ion mass spectrometry (TOF-SIMS). Polyethylene Glycols 48-68 fibrinogen beta chain Homo sapiens 23-33 21440897-0 2011 Detection of nisin and fibrinogen adsorption on poly(ethylene oxide) coated polyurethane surfaces by time-of-flight secondary ion mass spectrometry (TOF-SIMS). Polyurethanes 76-88 fibrinogen beta chain Homo sapiens 23-33 21316742-0 2011 Homocysteinylated fibrinogen forms disulfide-linked complexes with albumin. Disulfides 35-44 fibrinogen beta chain Homo sapiens 18-28 21316742-4 2011 We have shown that in vitro reaction of Hcys thiolactone with human fibrinogen (Hcys-fibrinogen) alters fibrinogen function in a manner similar to that in homocysteinemic rabbits. homocysteine thiolactone 40-56 fibrinogen beta chain Homo sapiens 68-78 21316742-4 2011 We have shown that in vitro reaction of Hcys thiolactone with human fibrinogen (Hcys-fibrinogen) alters fibrinogen function in a manner similar to that in homocysteinemic rabbits. homocysteine thiolactone 40-56 fibrinogen beta chain Homo sapiens 85-95 21316742-4 2011 We have shown that in vitro reaction of Hcys thiolactone with human fibrinogen (Hcys-fibrinogen) alters fibrinogen function in a manner similar to that in homocysteinemic rabbits. homocysteine thiolactone 40-56 fibrinogen beta chain Homo sapiens 85-95 21316742-5 2011 Several naturally-occurring mutations that introduce a new cysteine into fibrinogen are associated with clinical thrombosis due to increased resistance of clots to fibrinolysis. Cysteine 59-67 fibrinogen beta chain Homo sapiens 73-83 21316742-6 2011 In those cases the new cysteine mediates disulfide formation between the mutant fibrinogen and albumin. Cysteine 23-31 fibrinogen beta chain Homo sapiens 80-90 21316742-6 2011 In those cases the new cysteine mediates disulfide formation between the mutant fibrinogen and albumin. Disulfides 41-50 fibrinogen beta chain Homo sapiens 80-90 21316742-7 2011 We now report that Hcys-fibrinogen similarly forms disulfides with albumin in vitro, specifically through sites in its D-domain. Disulfides 51-61 fibrinogen beta chain Homo sapiens 24-34 21316742-11 2011 Similar to the utility of glycated hemoglobin as a marker for the deleterious effects of hyperglycemia, the level of fibrinogen-albumin complexes might possibly be a clinically useful marker for the level of homocysteine-associated damage in vivo. Homocysteine 208-220 fibrinogen beta chain Homo sapiens 117-127 21486002-5 2011 Interestingly, while both enantiomers of gulitol- and mannonamide-terminated monolayer resisted adsorption of proteins (bovine serum albumin, lysozyme, and fibrinogen) and confined biofilms formed on the micropatterns, the monolayers formed by the racemic mixture of either pair of enantiomers exhibited stronger antifouling chemistry against both protein adsorption and biofilm formation than monolayers formed by one enantiomer alone. Sorbitol 41-48 fibrinogen beta chain Homo sapiens 156-166 21486002-5 2011 Interestingly, while both enantiomers of gulitol- and mannonamide-terminated monolayer resisted adsorption of proteins (bovine serum albumin, lysozyme, and fibrinogen) and confined biofilms formed on the micropatterns, the monolayers formed by the racemic mixture of either pair of enantiomers exhibited stronger antifouling chemistry against both protein adsorption and biofilm formation than monolayers formed by one enantiomer alone. Mannonic amide 54-65 fibrinogen beta chain Homo sapiens 156-166 21080031-7 2011 Fibrinogen levels were linearly associated with baseline glycaemia (P < 0.017), WBC count (P < 0.0001), creatinine (P < 0.0001), and Platelet count (P < 0.0001) but inversely associated with RBC count (P < 0.0001). Creatinine 110-120 fibrinogen beta chain Homo sapiens 0-10 21211975-3 2011 OBJECTIVE: To evaluate the possible association of clinical effectiveness and plasma fibrinogen reduction with DMF therapy. Dimethylformamide 111-114 fibrinogen beta chain Homo sapiens 85-95 21211975-14 2011 CONCLUSION: DMF combined with conventional therapy for infected ischemic diabetic foot was associated with plasma fibrinogen decrease. Dimethylformamide 12-15 fibrinogen beta chain Homo sapiens 114-124 21521522-6 2011 SM levels were significantly correlated with fibrinogen levels, diabetes, apoB, and triglyceride levels. Sphingomyelins 0-2 fibrinogen beta chain Homo sapiens 45-55 21251962-4 2011 Therefore, we investigated the relationship between H12 density on the liposome and the binding ability to platelets, and evaluated the inhibitory effect of Fbg on the binding of H12-(ADP)Lipo to platelets. (adp)lipo 183-192 fibrinogen beta chain Homo sapiens 157-160 21251962-6 2011 The 50% inhibition concentration of Fbg on the binding of H12-(ADP)Lipo to platelets was about 25-fold over the concentration of H12 molecules on the liposome. Adenosine Diphosphate 63-66 fibrinogen beta chain Homo sapiens 36-39 22468040-9 2011 This study confirms a strong association between catecholamines as well as EGF-R/HER-1/erbB-1 levels with PTH and low vitamin D levels, being related to hyperlipidemia and inflammation (hsCRP and fibrinogen) in CVD. Catecholamines 49-63 fibrinogen beta chain Homo sapiens 186-206 22468040-9 2011 This study confirms a strong association between catecholamines as well as EGF-R/HER-1/erbB-1 levels with PTH and low vitamin D levels, being related to hyperlipidemia and inflammation (hsCRP and fibrinogen) in CVD. Vitamin D 118-127 fibrinogen beta chain Homo sapiens 186-206 21464904-8 2011 Our data also show that the sialic acids exposed on the erythrocyte membrane contribute for the interaction with fibrinogen, possibly by facilitating its binding to the erythrocyte membrane receptor. Sialic Acids 28-40 fibrinogen beta chain Homo sapiens 113-123 20641300-6 2004 A tripeptide sequence consisting of Arg-Gly-Asp (RGD) was identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins including alphavbeta3. tripeptide K-26 2-12 fibrinogen beta chain Homo sapiens 144-154 20641300-6 2004 A tripeptide sequence consisting of Arg-Gly-Asp (RGD) was identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins including alphavbeta3. Arginine 36-39 fibrinogen beta chain Homo sapiens 144-154 20641300-6 2004 A tripeptide sequence consisting of Arg-Gly-Asp (RGD) was identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins including alphavbeta3. Glycine 40-43 fibrinogen beta chain Homo sapiens 144-154 20641300-6 2004 A tripeptide sequence consisting of Arg-Gly-Asp (RGD) was identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins including alphavbeta3. Aspartic Acid 44-47 fibrinogen beta chain Homo sapiens 144-154 20977952-7 2011 The poly(HEMA)-lysine-modified surface was shown to reduce non-specific (fibrinogen) adsorption while binding plasminogen from plasma with high affinity. poly(2-hydroxyethyl methacrylate)-polyamine graft copolymer 4-14 fibrinogen beta chain Homo sapiens 73-83 20977952-7 2011 The poly(HEMA)-lysine-modified surface was shown to reduce non-specific (fibrinogen) adsorption while binding plasminogen from plasma with high affinity. Lysine 15-21 fibrinogen beta chain Homo sapiens 73-83 21192254-1 2011 Fibrinogen has previously been demonstrated to exist in a "fetal" form, in cord blood of term infants, with increased sialic acid content compared to adult fibrinogen. N-Acetylneuraminic Acid 118-129 fibrinogen beta chain Homo sapiens 0-10 20607353-11 2011 Correlations were found between ETG and Fg (r = 0.44, P < 0.01). etg 32-35 fibrinogen beta chain Homo sapiens 40-42 21365353-11 2011 Highest levobupivacaine concentration correlated significantly with lowest ICG (P = 0.0004; R = 0.69), highest bilirubin (P = 0.0267; R = 0.49), lowest fibrinogen concentration (R = 0.32), but not with cholinesterase activity (R = 0.02). Levobupivacaine 8-23 fibrinogen beta chain Homo sapiens 152-162 21460246-4 2011 We show that host fibrinogen (FG) was constantly present (at ~ 1 FG per 25 000 HZ-heme molecules) and stably bound to nHZ from plasma-cultured parasites. Heme 82-86 fibrinogen beta chain Homo sapiens 30-32 21460246-5 2011 FG was responsible for the rapid 100-fold stimulation of reactive oxygen species production and 50-fold increase of TNF and monocyte chemotactic protein 1 by human monocytes. Reactive Oxygen Species 57-80 fibrinogen beta chain Homo sapiens 0-2 21491854-3 2011 Interfacial rheology showed that fibrinogen has a low dilatational modulus at the air-water interface when compared to other proteins, suggesting the formation of a weak surface network. Water 86-91 fibrinogen beta chain Homo sapiens 33-43 21491854-4 2011 Fluorinated and hydrogenated surfactants severely decreased the dilatational modulus of the adsorbed fibrinogen film at the air-water interface. Water 128-133 fibrinogen beta chain Homo sapiens 101-111 21491854-5 2011 These measurements suggest the progressive displacement of fibrinogen from the air-water interface by both types of surfactants. Water 83-88 fibrinogen beta chain Homo sapiens 59-69 21286925-6 2011 Neopterin and fibrinogen did not correlate significantly, but there was a trend to higher fibrinogen concentrations in patients with higher neopterin levels (rs = 0.344, p = 0.062). Neopterin 140-149 fibrinogen beta chain Homo sapiens 90-100 21472635-11 2011 Patients with valproate therapy had a significantly lower fibrinogen concentration. Valproic Acid 14-23 fibrinogen beta chain Homo sapiens 58-68 21324664-3 2011 The bivalent TBAs interacted specifically with thrombin, suppressing its activity toward fibrinogen-modified Au NPs (Fib-Au NPs). thrombin aptamer 13-17 fibrinogen beta chain Homo sapiens 89-99 21391676-8 2011 Surprisingly, a monolayer of 5000 Da poly(ethylene glycol) (PEG5000) increased surface residence time and slowed diffusion of fibrinogen relative to bare fused silica or hydrophobically modified fused silica, suggesting that the mechanism of PEG resistance to protein adhesion is more sophisticated than the simple repulsion of individual proteins. Polyethylene Glycols 37-58 fibrinogen beta chain Homo sapiens 126-136 21391676-8 2011 Surprisingly, a monolayer of 5000 Da poly(ethylene glycol) (PEG5000) increased surface residence time and slowed diffusion of fibrinogen relative to bare fused silica or hydrophobically modified fused silica, suggesting that the mechanism of PEG resistance to protein adhesion is more sophisticated than the simple repulsion of individual proteins. peg5000 60-67 fibrinogen beta chain Homo sapiens 126-136 21156217-6 2011 Low vitamin D levels were also significantly associated with carotid artery intima media thickness (p<0.001), fibrinogen (p=0.010), total cholesterol (p=0.042) and ApoA1 (p=0.004) levels. Vitamin D 4-13 fibrinogen beta chain Homo sapiens 113-123 21301788-1 2011 A novel dysfibrinogenaemia with a replacement of Tyr by Asn at Bbeta41 has been discovered (fibrinogen Caracas VIII). Tyrosine 49-52 fibrinogen beta chain Homo sapiens 11-21 21301788-1 2011 A novel dysfibrinogenaemia with a replacement of Tyr by Asn at Bbeta41 has been discovered (fibrinogen Caracas VIII). Asparagine 56-59 fibrinogen beta chain Homo sapiens 11-21 21215609-4 2011 We further used thrombin-conjugated Au NPs (Thr-Au NPs) to analyze the levels of fibrinogen in plasma samples via fibrinogen-induced aggregation of Thr-Au NPs. Threonine 44-47 fibrinogen beta chain Homo sapiens 81-91 21215609-4 2011 We further used thrombin-conjugated Au NPs (Thr-Au NPs) to analyze the levels of fibrinogen in plasma samples via fibrinogen-induced aggregation of Thr-Au NPs. Threonine 44-47 fibrinogen beta chain Homo sapiens 114-124 21215609-4 2011 We further used thrombin-conjugated Au NPs (Thr-Au NPs) to analyze the levels of fibrinogen in plasma samples via fibrinogen-induced aggregation of Thr-Au NPs. Threonine 148-151 fibrinogen beta chain Homo sapiens 81-91 21215609-4 2011 We further used thrombin-conjugated Au NPs (Thr-Au NPs) to analyze the levels of fibrinogen in plasma samples via fibrinogen-induced aggregation of Thr-Au NPs. Threonine 148-151 fibrinogen beta chain Homo sapiens 114-124 21215609-6 2011 The Thr-Au NP probe provided quantitative results for fibrinogen in plasma samples that correlated (R(2)=0.97) with those obtained using a clinical von Clauss clotting rate assay. Threonine 4-7 fibrinogen beta chain Homo sapiens 54-64 21279672-7 2011 Meanwhile, the adsorption of blood proteins such as, human serum albumin (HSA) and fibrinogen was found considerably down-regulated in DLC-PEG-N-S, due mainly to the protein-repellent effect of PEG and zwitterion. peg-n-s 139-146 fibrinogen beta chain Homo sapiens 59-93 21279672-7 2011 Meanwhile, the adsorption of blood proteins such as, human serum albumin (HSA) and fibrinogen was found considerably down-regulated in DLC-PEG-N-S, due mainly to the protein-repellent effect of PEG and zwitterion. Polyethylene Glycols 139-142 fibrinogen beta chain Homo sapiens 59-93 21417688-1 2011 Ingested, inhaled or injected particles come into contact with biological fluids containing polymers, such as the protein fibrinogen. Polymers 92-100 fibrinogen beta chain Homo sapiens 122-132 21417688-6 2011 We concluded: (1) NP aggregation rate in a fibrinogen solution depended on particle surface type; (2) amine-functionalized particles aggregated more slowly in fibrinogen; and (3) particle morphology strongly influenced biologically available surface for protein attachment, but this did not correlate well with particle surface area for complex particles (calculated or measured). Amines 102-107 fibrinogen beta chain Homo sapiens 159-169 21192636-3 2011 The conformational analysis of a large population of fibrinogen molecules on mica revealed the two most energetically favorable conformations characterized by bending angles of ~100 and 160 degrees. mica 77-81 fibrinogen beta chain Homo sapiens 53-63 21535951-4 2011 The Fg of three probands was assessed by Western blot and sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE). Sodium Dodecyl Sulfate 58-80 fibrinogen beta chain Homo sapiens 4-6 21535951-4 2011 The Fg of three probands was assessed by Western blot and sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE). polyacrylamide gels 81-99 fibrinogen beta chain Homo sapiens 4-6 21535951-4 2011 The Fg of three probands was assessed by Western blot and sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE). Sodium Dodecyl Sulfate 117-120 fibrinogen beta chain Homo sapiens 4-6 21343206-11 2011 Alcohol decreased fibrinogen levels (-0.20 g/L, -0.29 to -0.11) but did not affect triglyceride levels. Alcohols 0-7 fibrinogen beta chain Homo sapiens 18-28 21192636-5 2011 Imaging in different environments supports the expected hydration of the fibrinogen molecules in buffer, whereas imaging in humid air suggests the 2D spreading of fibrinogen on mica induced by an adsorbed water layer. mica 177-181 fibrinogen beta chain Homo sapiens 163-173 21192636-5 2011 Imaging in different environments supports the expected hydration of the fibrinogen molecules in buffer, whereas imaging in humid air suggests the 2D spreading of fibrinogen on mica induced by an adsorbed water layer. Water 205-210 fibrinogen beta chain Homo sapiens 163-173 21093043-6 2011 We have observed the aggregation of the nanoparticles induced by fibrinogen, and found that it was prevented when the density of dextran chains protruding from the core surface was sufficiently high. Dextrans 129-136 fibrinogen beta chain Homo sapiens 65-75 21071185-0 2011 Mechanisms of fibrinogen-acebutolol interactions: Insights from DSC, CD and LS. Acebutolol 25-35 fibrinogen beta chain Homo sapiens 14-24 21071185-1 2011 The complex formed due to the interaction of the amphiphilic betablocker acebutolol with fibrinogen in a buffer solution (50mN glycine, pH of 8.5) has been investigated using a multipronged physicochemical approach. Acebutolol 73-83 fibrinogen beta chain Homo sapiens 89-99 21071185-1 2011 The complex formed due to the interaction of the amphiphilic betablocker acebutolol with fibrinogen in a buffer solution (50mN glycine, pH of 8.5) has been investigated using a multipronged physicochemical approach. Glycine 127-134 fibrinogen beta chain Homo sapiens 89-99 21071185-2 2011 Differential scanning calorimetry measurements of the complexes have shown no reversibility of thermal denaturation as indicated by the three observed peaks and the opposite role that acebutolol plays in the folding different domains of the fibrinogen molecule and the stability of such domains. Acebutolol 184-194 fibrinogen beta chain Homo sapiens 241-251 21071185-3 2011 While circular dichroism measurements have revealed that interaction of acebutolol with fibrinogen affects the protein secondary structure to a different extent depending on the temperature and drug concentration, dynamic light scattering analysis showed evidence for protein aggregation mainly to tetramers and dimers. Acebutolol 72-82 fibrinogen beta chain Homo sapiens 88-98 21136015-6 2011 Carriers of the H2H2 genotype of the G-455>A polymorphism had increased fibrinogen levels, particularly in association with increased CRP levels. h2h2 16-20 fibrinogen beta chain Homo sapiens 75-85 21147952-9 2011 In addition, clfA and fnbA genetic polymorphisms were detected that were linked to ClfA and FnbA amino acid changes that may significantly reduce fibrinogen-binding activity. clfa 13-17 fibrinogen beta chain Homo sapiens 146-156 21147952-9 2011 In addition, clfA and fnbA genetic polymorphisms were detected that were linked to ClfA and FnbA amino acid changes that may significantly reduce fibrinogen-binding activity. clfa 83-87 fibrinogen beta chain Homo sapiens 146-156 22214711-1 2011 Recent evidence has shown that plasma fibrinogen, a major cardiovascular risk factor, interacts with the erythrocyte membrane and acts to influence blood flow via erythrocyte nitric oxide (NO) modulation. Nitric Oxide 175-187 fibrinogen beta chain Homo sapiens 38-48 21249762-5 2004 The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3. Arginine 21-24 fibrinogen beta chain Homo sapiens 134-144 21249762-5 2004 The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3. Glycine 25-28 fibrinogen beta chain Homo sapiens 134-144 21249762-5 2004 The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3. Aspartic Acid 29-32 fibrinogen beta chain Homo sapiens 134-144 22108001-12 2011 Immunization of DBA/1J mice with citBiP induced several kinds of ACPAs, including anti-CCP and anti-citrullinated fibrinogen antibodies. citbip 33-39 fibrinogen beta chain Homo sapiens 114-124 21995153-1 2011 OBJECTIVE: To evaluate thromboelastographic parameters and fibrinogen levels in women treated with transdermal 17beta estradiol. Estradiol 111-127 fibrinogen beta chain Homo sapiens 59-69 23008706-10 2011 The free testosterone had significant negative correlation with fibrinogen, PAI-1, hsCRP and IL-6 in both groups of patients. Testosterone 9-21 fibrinogen beta chain Homo sapiens 64-74 20852292-9 2011 As for those < 60 years, between lone AF and age-matched controls, significant difference existed in the levels of sP-sel (AF vs. control: 34.5 +- 7.3 vs. 30.2 +- 7.3 ng/mL, P = 0.002), but not in those of fibrinogen and vWf, whether with the adjustment of covariates or not. TFF2 protein, human 118-120 fibrinogen beta chain Homo sapiens 209-219 22514360-6 2011 By focusing on molecular volume, the model can be applied to non-spherical molecules such as fibrinogen and accurately captures differences between BSA, multi-layer, and HSA, monolayer, adsorption. Altretamine 170-173 fibrinogen beta chain Homo sapiens 93-103 20546677-5 2011 Resistance of the coatings to protein fouling was examined by measurement of fibrinogen adsorption from fibrinogen solution and human plasma on coated silicon surfaces. Silicon 151-158 fibrinogen beta chain Homo sapiens 77-87 20946166-4 2011 MATERIALS AND METHODS: Rivaroxaban was added to plasma from healthy subjects in the concentration range 0-1000 mug L(-1) and analyzed using different reagents for activated partial thromboplastin time (APTT), prothrombin time (PT), antithrombin, fibrinogen and activated protein C (APC) resistance assays. Rivaroxaban 23-34 fibrinogen beta chain Homo sapiens 246-256 20594411-5 2011 The adsorption of vitronectin, thrombin, fibrinogen and complement component C3 was significantly lower on PEG hydrogels than on tissue culture polystyrene (TCPS). Polyethylene Glycols 107-110 fibrinogen beta chain Homo sapiens 41-51 21105163-2 2011 In previous studies, we therefore prepared radiofrequency glow discharge (ethylene oxide)-like tetraglyme (CH(3)O(CH(2)CH(2)O)(4)CH(3)) coatings adsorbing <10 ng/cm(2) Fg and showed that they had the expected low monocyte adhesion in vitro. Ethylene Oxide 74-88 fibrinogen beta chain Homo sapiens 171-173 21602602-4 2011 Furthermore, m(r)CRP (100 mug/ml) strongly augmented spontaneous and ADP-induced fibrinogen binding to platelets (p < 0.05), platelet adhesion to fibrinogen and platelet aggregation. Adenosine Diphosphate 69-72 fibrinogen beta chain Homo sapiens 81-91 21170037-3 2011 Here, we show that negatively charged poly(acrylic acid)-conjugated gold nanoparticles bind to and induce unfolding of fibrinogen, which promotes interaction with the integrin receptor, Mac-1. carbopol 940 38-56 fibrinogen beta chain Homo sapiens 119-129 21904647-4 2011 In addition, hydroxyl radicals can reduce disulfide bonds in proteins, specifically fibrinogen, resulting in their unfolding and scrambled refolding into abnormal spatial configurations. Hydroxyl Radical 13-30 fibrinogen beta chain Homo sapiens 84-94 21904647-4 2011 In addition, hydroxyl radicals can reduce disulfide bonds in proteins, specifically fibrinogen, resulting in their unfolding and scrambled refolding into abnormal spatial configurations. Disulfides 42-51 fibrinogen beta chain Homo sapiens 84-94 21602602-4 2011 Furthermore, m(r)CRP (100 mug/ml) strongly augmented spontaneous and ADP-induced fibrinogen binding to platelets (p < 0.05), platelet adhesion to fibrinogen and platelet aggregation. Adenosine Diphosphate 69-72 fibrinogen beta chain Homo sapiens 149-159 21158497-2 2011 We have previously reported the synthesis of a highly constrained cyclic peptide, that incorporates the -CDC- sequence, (S,S) PSRCDCR-NH(2), which potently inhibits aggregation and fibrinogen binding to human platelets in vitro. psrcdcr- 126-134 fibrinogen beta chain Homo sapiens 181-191 21388249-5 2011 Thrombin-induced alpha-granule secretion, measured by the release of fibrinogen in gel-filtered platelets, was also potentiated by adrenaline at thrombin concentrations above 0.05 U/ml. Epinephrine 131-141 fibrinogen beta chain Homo sapiens 69-79 21388249-7 2011 When autocrine stimulation was inhibited by the removal of secreted ADP by creatine phosphate/creatine phosphate kinase and specific blocking of the thromboxane A(2) and fibrinogen receptors, the potentiation of thrombin-induced ADP + ATP secretion by adrenaline was reduced and this reduction was mostly due to the blocking of the thromboxane A(2) receptor. Adenosine Diphosphate 229-232 fibrinogen beta chain Homo sapiens 170-180 21388249-7 2011 When autocrine stimulation was inhibited by the removal of secreted ADP by creatine phosphate/creatine phosphate kinase and specific blocking of the thromboxane A(2) and fibrinogen receptors, the potentiation of thrombin-induced ADP + ATP secretion by adrenaline was reduced and this reduction was mostly due to the blocking of the thromboxane A(2) receptor. Adenosine Triphosphate 235-238 fibrinogen beta chain Homo sapiens 170-180 21388249-7 2011 When autocrine stimulation was inhibited by the removal of secreted ADP by creatine phosphate/creatine phosphate kinase and specific blocking of the thromboxane A(2) and fibrinogen receptors, the potentiation of thrombin-induced ADP + ATP secretion by adrenaline was reduced and this reduction was mostly due to the blocking of the thromboxane A(2) receptor. Epinephrine 252-262 fibrinogen beta chain Homo sapiens 170-180 19744701-8 2011 K(s) of fibrin gels obtained from purified systems with fibrinogen incubated with homocysteine was (7.07 +- 0.27) x 10(-9) cm(2), control was (11.40 +- 0.37) x 10(-9) cm(2) (n = 3; p < 0.01). Homocysteine 82-94 fibrinogen beta chain Homo sapiens 56-66 19744701-10 2011 Plasma incubated with high homocysteine concentrations produced fibrin clots significantly less permeable than controls in a dose dependent manner, and the results showed that fibrinogen and factor XIII were involved in that detrimental effect. Homocysteine 27-39 fibrinogen beta chain Homo sapiens 176-186 20870435-0 2010 Benign substitution (Aalpha289 Arg Gln) in the alphaC region of human fibrinogen. Arginine 31-34 fibrinogen beta chain Homo sapiens 70-80 20870435-0 2010 Benign substitution (Aalpha289 Arg Gln) in the alphaC region of human fibrinogen. Glutamine 35-38 fibrinogen beta chain Homo sapiens 70-80 20797426-5 2010 The flow method introduced here was employed to determine the effect of Tbeta(4), on the deposition of ADP-activated platelets onto fibrinogen cross-linked flow chambers. Adenosine Diphosphate 103-106 fibrinogen beta chain Homo sapiens 132-142 20881480-1 2010 We investigated the association between alcohol consumption and plasminogen activator inhibitor-1 activity (PAI-1act) and fibrinogen concentration in a black South African population presenting with lower PAI-1act and higher fibrinogen than what is typically observed in white populations. Alcohols 40-47 fibrinogen beta chain Homo sapiens 122-132 20881480-2 2010 We, furthermore, wanted to investigate the effect of urbanization, sex, central obesity, increased triglycerides, 4G/5G polymorphism (PAI-1 only) and BMI on the association of alcohol with PAI-1act and fibrinogen. Alcohols 176-183 fibrinogen beta chain Homo sapiens 189-212 20881480-8 2010 Moderate alcohol consumption is associated with decreased fibrinogen concentration. Alcohols 9-16 fibrinogen beta chain Homo sapiens 58-68 20801620-2 2010 In this work, the effects of the dextran and PEG on the morphology, wetting, and surface charge of the resulting surfaces were quantified and correlated with changes in the amount of fibrinogen and albumin adsorbed from aqueous solution. Dextrans 33-40 fibrinogen beta chain Homo sapiens 183-193 20801620-2 2010 In this work, the effects of the dextran and PEG on the morphology, wetting, and surface charge of the resulting surfaces were quantified and correlated with changes in the amount of fibrinogen and albumin adsorbed from aqueous solution. Polyethylene Glycols 45-48 fibrinogen beta chain Homo sapiens 183-193 20801620-8 2010 The PEG- and dextran-modified PDMS were exposed to BSA and fibrinogen to test their resistance to protein adsorption. Polyethylene Glycols 4-7 fibrinogen beta chain Homo sapiens 59-69 20801620-8 2010 The PEG- and dextran-modified PDMS were exposed to BSA and fibrinogen to test their resistance to protein adsorption. Dextrans 13-20 fibrinogen beta chain Homo sapiens 59-69 20829000-1 2010 Adsorption of fibrinogen to the monolayers of mixed lipids, dipalmitoyl phosphatidyl choline (DPPC) and eicosylamine (EA) was measured at a surface pressure of 20 mN/m by an in situ surface plasmon resonance technique. 1,2-Dipalmitoylphosphatidylcholine 60-92 fibrinogen beta chain Homo sapiens 14-24 20829000-1 2010 Adsorption of fibrinogen to the monolayers of mixed lipids, dipalmitoyl phosphatidyl choline (DPPC) and eicosylamine (EA) was measured at a surface pressure of 20 mN/m by an in situ surface plasmon resonance technique. 1,2-Dipalmitoylphosphatidylcholine 94-98 fibrinogen beta chain Homo sapiens 14-24 20829000-1 2010 Adsorption of fibrinogen to the monolayers of mixed lipids, dipalmitoyl phosphatidyl choline (DPPC) and eicosylamine (EA) was measured at a surface pressure of 20 mN/m by an in situ surface plasmon resonance technique. icosan-1-amine 104-116 fibrinogen beta chain Homo sapiens 14-24 20829000-5 2010 At a higher protein concentration (0.06 mg/ml) both the fibrinogen adsorbed amount and its maximum adsorption rate showed excess values relative to the pure EA for 1:1, 2:1 and 3:1 DPPC+EA monolayers. ea 157-159 fibrinogen beta chain Homo sapiens 56-66 20829000-5 2010 At a higher protein concentration (0.06 mg/ml) both the fibrinogen adsorbed amount and its maximum adsorption rate showed excess values relative to the pure EA for 1:1, 2:1 and 3:1 DPPC+EA monolayers. 1,2-Dipalmitoylphosphatidylcholine 181-185 fibrinogen beta chain Homo sapiens 56-66 20829000-5 2010 At a higher protein concentration (0.06 mg/ml) both the fibrinogen adsorbed amount and its maximum adsorption rate showed excess values relative to the pure EA for 1:1, 2:1 and 3:1 DPPC+EA monolayers. ea 186-188 fibrinogen beta chain Homo sapiens 56-66 20880206-5 2010 Fibrinogen aggregation was induced under non-enzymatic conditions by adsorption on a trioctyl-surface monolayer (trioctylmethylamine) grafted onto silica clay plates. trioctyl 85-93 fibrinogen beta chain Homo sapiens 0-10 20880206-5 2010 Fibrinogen aggregation was induced under non-enzymatic conditions by adsorption on a trioctyl-surface monolayer (trioctylmethylamine) grafted onto silica clay plates. trioctylmethylamine 113-132 fibrinogen beta chain Homo sapiens 0-10 20880206-5 2010 Fibrinogen aggregation was induced under non-enzymatic conditions by adsorption on a trioctyl-surface monolayer (trioctylmethylamine) grafted onto silica clay plates. silica clay 147-158 fibrinogen beta chain Homo sapiens 0-10 21119577-7 2010 RESULTS: Estradiol and free estradiol levels were positively correlated with C-reactive protein and fibrinogen. Estradiol 9-18 fibrinogen beta chain Homo sapiens 100-110 21119577-7 2010 RESULTS: Estradiol and free estradiol levels were positively correlated with C-reactive protein and fibrinogen. Estradiol 28-37 fibrinogen beta chain Homo sapiens 100-110 20219150-6 2010 RESULTS: Higher self-rated distress was positively associated with fibrinogen level in this young population, independently of age, sex, ethnicity, body mass index (BMI), high density lipoprotein (HDL) cholesterol, smoking, and alcohol and medication use (beta=0.024, p<0.01). Alcohols 228-235 fibrinogen beta chain Homo sapiens 67-77 20954736-10 2010 Glycopolymer brushes containing glucose units showed relatively better protection against BSA and Fb adsorption than those brushes containing mannose and galactose units. glycopolymer 0-12 fibrinogen beta chain Homo sapiens 98-100 20954736-10 2010 Glycopolymer brushes containing glucose units showed relatively better protection against BSA and Fb adsorption than those brushes containing mannose and galactose units. Glucose 32-39 fibrinogen beta chain Homo sapiens 98-100 20828133-4 2010 Eptifibatide competitively inhibited fibrinogen"s interactions with primed alphaIIbbeta3 (K(i) ~0.4 nM), while a synthetic gamma-module peptide (HHLGGAKQAGDV) was only weakly inhibitory (K(i) > 10 muM). Eptifibatide 0-12 fibrinogen beta chain Homo sapiens 37-47 21197412-1 2010 We hypothesized that soy isoflavones would attenuate the anticipated increase in androidal fat mass in postmenopausal women during the 36-month treatment, and thereby favorably modify the circulating cardiometabolic risk factors: triacylglycerol, LDL-C, HDL-C, glucose, insulin, uric acid, C-reactive protein, fibrinogen, and homocysteine. Isoflavones 25-36 fibrinogen beta chain Homo sapiens 310-320 20939050-2 2010 Although fibrinogen (Fg) is usually considered the main factor in mediating phagocyte attachment, plasma deposited PEO-like tetraethylene glycol dimethyl ether (tetraglyme) coatings that have ultra-low Fg adsorption (<10 ng cm(-2)) from low concentration solutions and low monocyte adhesion in vitro still show high phagocyte adhesion after short implantations and later become encapsulated when tested in vivo. tetraglyme 124-159 fibrinogen beta chain Homo sapiens 202-204 20939050-2 2010 Although fibrinogen (Fg) is usually considered the main factor in mediating phagocyte attachment, plasma deposited PEO-like tetraethylene glycol dimethyl ether (tetraglyme) coatings that have ultra-low Fg adsorption (<10 ng cm(-2)) from low concentration solutions and low monocyte adhesion in vitro still show high phagocyte adhesion after short implantations and later become encapsulated when tested in vivo. tetraglyme 161-171 fibrinogen beta chain Homo sapiens 21-23 20939050-2 2010 Although fibrinogen (Fg) is usually considered the main factor in mediating phagocyte attachment, plasma deposited PEO-like tetraethylene glycol dimethyl ether (tetraglyme) coatings that have ultra-low Fg adsorption (<10 ng cm(-2)) from low concentration solutions and low monocyte adhesion in vitro still show high phagocyte adhesion after short implantations and later become encapsulated when tested in vivo. tetraglyme 161-171 fibrinogen beta chain Homo sapiens 202-204 20876456-3 2010 We show here that aluminum salt nodules formed within hours of injection and contained the clotting protein fibrinogen. aluminum salt 18-31 fibrinogen beta chain Homo sapiens 108-118 21204315-13 2004 The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (e.g., vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3. Arginine 21-24 fibrinogen beta chain Homo sapiens 140-150 21204315-13 2004 The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (e.g., vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3. Glycine 25-28 fibrinogen beta chain Homo sapiens 140-150 21204315-13 2004 The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (e.g., vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3. Aspartic Acid 29-32 fibrinogen beta chain Homo sapiens 140-150 20650615-8 2010 Vastly different amounts of fibrinogen were found to adsorb on pure copper when measured using in situ or ex situ techniques due to a copper corrosion effect that occurs during ex situ measurements. Copper 68-74 fibrinogen beta chain Homo sapiens 28-38 20650615-8 2010 Vastly different amounts of fibrinogen were found to adsorb on pure copper when measured using in situ or ex situ techniques due to a copper corrosion effect that occurs during ex situ measurements. Copper 134-140 fibrinogen beta chain Homo sapiens 28-38 20666993-6 2010 Purified fibrinogen was analysed by sodium dodecyl sulphate-polyacrylamide gel electrophoresis and reverse phase high performance liquid chromatography; DNA sequencing was performed using a BigDye Terminator (v. 3.1) cycle sequencing kit. Sodium Dodecyl Sulfate 36-59 fibrinogen beta chain Homo sapiens 9-19 20666993-6 2010 Purified fibrinogen was analysed by sodium dodecyl sulphate-polyacrylamide gel electrophoresis and reverse phase high performance liquid chromatography; DNA sequencing was performed using a BigDye Terminator (v. 3.1) cycle sequencing kit. polyacrylamide 60-74 fibrinogen beta chain Homo sapiens 9-19 19695851-7 2010 We found alcohol consumption in older age associated with healthier hematological values of fibrinogen, HDL cholesterol, Apo A-I lipoprotein and insulin, but it was also associated with a worse hematological picture of total, LDL cholesterol levels, and systolic pressure. Alcohols 9-16 fibrinogen beta chain Homo sapiens 92-102 21273666-7 2010 In both IFG and hypercholesterolemic patients, simvastatin reduced fibrinogen and PAI-1 levels and factor VII activity, and it prolonged the prothrombin and partial thromboplastin time in a lipid- and glucose-independent manner. Simvastatin 47-58 fibrinogen beta chain Homo sapiens 67-77 21273669-3 2010 In the present study, we monitored the effect of the phytoestrogen ferutinin, which acts as a Ca(2+) ionophore in human blood platelets; its ionophore-like properties include upregulation of [Ca(2+)](in), activation of fibrinogen receptors and increased fibrinogen binding. 4-oxy-6-(4-oxybezoyloxy)dauc-8,9-en 67-76 fibrinogen beta chain Homo sapiens 219-229 21273669-3 2010 In the present study, we monitored the effect of the phytoestrogen ferutinin, which acts as a Ca(2+) ionophore in human blood platelets; its ionophore-like properties include upregulation of [Ca(2+)](in), activation of fibrinogen receptors and increased fibrinogen binding. 4-oxy-6-(4-oxybezoyloxy)dauc-8,9-en 67-76 fibrinogen beta chain Homo sapiens 254-264 21029470-8 2010 After adjusting for age and sex, the following were significantly associated with fibrinogen: BMI, waist, waist-hip ratio, systolic blood pressure, heart rate, fasting triglycerides, HDL cholesterol, HbA1c, CRP, ACR and alcohol abstinence. Alcohols 220-227 fibrinogen beta chain Homo sapiens 82-92 20850171-3 2010 Trimarin showed proteolytic activity towards casein and fibrinogen, which was irreversibly inhibited by EDTA and 1,10-phenanthroline. trimarin 0-8 fibrinogen beta chain Homo sapiens 56-66 20850171-3 2010 Trimarin showed proteolytic activity towards casein and fibrinogen, which was irreversibly inhibited by EDTA and 1,10-phenanthroline. Edetic Acid 104-108 fibrinogen beta chain Homo sapiens 56-66 20850171-3 2010 Trimarin showed proteolytic activity towards casein and fibrinogen, which was irreversibly inhibited by EDTA and 1,10-phenanthroline. 1,10-phenanthroline 113-132 fibrinogen beta chain Homo sapiens 56-66 20869101-0 2010 Effect of resveratrol on hemostatic properties of human fibrinogen and plasma during model of hyperhomocysteinemia. Resveratrol 10-21 fibrinogen beta chain Homo sapiens 56-66 20869101-2 2010 In this study the influence of resveratrol on the clot formation (using human plasma and purified fibrinogen) and the fibrin lysis during model of hyperhomocysteinemia was investigated. Resveratrol 31-42 fibrinogen beta chain Homo sapiens 98-108 20869101-5 2010 We observed that HTL, like its precursor, Hcys stimulated polymerization of fibrinogen. Homocysteine 42-46 fibrinogen beta chain Homo sapiens 76-86 20869101-8 2010 Our results indicate that resveratrol reduced the toxicity action of Hcys and HTL on hemostatic properties of fibrinogen or plasma, suggesting its possible protector role in hyperhomocysteinemia - induced cardiovascular diseases. Resveratrol 26-37 fibrinogen beta chain Homo sapiens 110-120 20602495-6 2010 Atomic force microscopy images of fibrinogen adsorption on Si model surfaces with different hydrophobicity are compared to the results. Silicon 59-61 fibrinogen beta chain Homo sapiens 34-44 20935705-1 2010 Adsorption of the elongated human plasma fibrinogen (HPF) and globular human serum albumin molecules on a titanium-based surface is monitored by analyzing permittivity and optical roughness of protein-modified surfaces by using a diffractive optical element (DOE)-based sensor and variable angle spectro-ellipsometry (VASE). Titanium 106-114 fibrinogen beta chain Homo sapiens 41-51 20533540-12 2010 CONCLUSION: Activated citrulline-specific T cells play a direct role in the development and progression of arthritis in this model of Cit-human fibrinogen-induced RA. Citrulline 22-32 fibrinogen beta chain Homo sapiens 144-154 20881480-10 2010 Fibrinogen decreased in normal and overweight volunteers but not in obese and centrally obese volunteers following moderate alcohol consumption. Alcohols 124-131 fibrinogen beta chain Homo sapiens 0-10 20876960-5 2010 The amounts of human fibrinogen (HFG) and human serum albumin (HSA) adsorbing on the ZnO films and reference samples were determined by using enzyme-linked immunosorbent assay (ELISA). Zinc Oxide 85-88 fibrinogen beta chain Homo sapiens 21-31 20854623-8 2010 Evidence also suggests significant associations of increased homocysteine and fibrinogen concentrations with ischaemic stroke, but whether these associations are causal is still debated. Homocysteine 61-73 fibrinogen beta chain Homo sapiens 78-88 20881480-12 2010 Obesity prevented alcohol-related fibrinogen decrease possibly by counteracting the anti-inflammatory effect of moderate alcohol consumption. Alcohols 18-25 fibrinogen beta chain Homo sapiens 34-44 21166647-1 2010 Ozone-induced free-radical oxidation of fragments D and E from fibrinogen has been studied. Ozone 0-5 fibrinogen beta chain Homo sapiens 63-73 20870869-6 2010 Those associated with pain are often responsive to low-molecular-weight heparin, which should also be used to avoid disseminated intravascular coagulopathy secondary to intervention, especially if fibrinogen level is low. Heparin 72-79 fibrinogen beta chain Homo sapiens 197-207 20717713-6 2010 It greatly decreased levels of plasmatic fibrinogen when administered to rats for 24 h. This fibrinogenase hydrolyzes the Bbeta chain of human fibrinogen in vitro releasing fibrinopeptide B only. bbeta 122-127 fibrinogen beta chain Homo sapiens 41-51 20717713-6 2010 It greatly decreased levels of plasmatic fibrinogen when administered to rats for 24 h. This fibrinogenase hydrolyzes the Bbeta chain of human fibrinogen in vitro releasing fibrinopeptide B only. bbeta 122-127 fibrinogen beta chain Homo sapiens 93-103 20571633-0 2010 Conformational behavior of fibrinogen on topographically modified polymer surfaces. Polymers 66-73 fibrinogen beta chain Homo sapiens 27-37 20624109-0 2010 High-dose fibrinogen concentrate for haemostatic therapy of a major trauma patient with recent clopidogrel and aspirin intake. Clopidogrel 95-106 fibrinogen beta chain Homo sapiens 10-20 20624109-0 2010 High-dose fibrinogen concentrate for haemostatic therapy of a major trauma patient with recent clopidogrel and aspirin intake. Aspirin 111-118 fibrinogen beta chain Homo sapiens 10-20 27877351-1 2010 The repeatability of the adsorption and removal of fibrinogen and fetal bovine serum on hydroxyapatite (HAp) nanocrystal sensors was investigated by Fourier transform infrared (FTIR) spectroscopy and quartz crystal microbalance with dissipation (QCM-D) monitoring technique. Durapatite 88-102 fibrinogen beta chain Homo sapiens 51-61 20731339-0 2010 Calcium dependence of fibrin nanomechanics: the gamma1 calcium mediates the unfolding of fibrinogen induced by force applied to the "A-a" bond. Calcium 0-7 fibrinogen beta chain Homo sapiens 89-99 20731339-0 2010 Calcium dependence of fibrin nanomechanics: the gamma1 calcium mediates the unfolding of fibrinogen induced by force applied to the "A-a" bond. Calcium 55-62 fibrinogen beta chain Homo sapiens 89-99 20731339-6 2010 Rather, calcium bound at the gamma1 site makes the structure of the hole more resilient to such forced unfolding, leading to survival of the "A-a" knob-hole bond during larger extensions of the fibrinogen molecule but at the cost of rupture of the bond at lower forces. Calcium 8-15 fibrinogen beta chain Homo sapiens 194-204 20823505-7 2010 Membrane formation was self-limiting, with fibrinogen membranes showing greater solute permeability than albumin, based on dye transport (Ponceau S, Meldola Blue). ponceau S 138-147 fibrinogen beta chain Homo sapiens 43-53 20506214-8 2010 Incubation of wild-type P gingivalis with fibrinogen or alpha-enolase caused degradation of the proteins and citrullination of the resulting peptides at carboxy-terminal arginine residues, which were identified by mass spectrometry. Arginine 170-178 fibrinogen beta chain Homo sapiens 42-52 20950258-4 2010 This review addresses and highlights the different inhibitions against metastases in vivo and molecular mechanisms in vitro of Biz compounds especially relating to the inhibitions of tumor metastasis including pathways of inhibitions against angiogenesis, topoisomerase II, calmodulin, sialic acid, fibrinogen, cell-movement and so on. BIZ 127-130 fibrinogen beta chain Homo sapiens 299-309 20823505-7 2010 Membrane formation was self-limiting, with fibrinogen membranes showing greater solute permeability than albumin, based on dye transport (Ponceau S, Meldola Blue). Meldola blue 149-161 fibrinogen beta chain Homo sapiens 43-53 20823505-9 2010 Larger surface area membranes formed at a static liquid-liquid interface served as a more physically accessible model and allowed precise electrochemical determination of acetaminophen, catechol and peroxide diffusion coefficients, which confirmed the greater fibrinogen permeability. Peroxides 199-207 fibrinogen beta chain Homo sapiens 260-270 20075386-4 2010 METHODS: Fibrinogen was purified from 96 subjects (17 with CTEPH, 14 with PAH, 39 with prior PE, and 26 healthy control subjects) and exposed to thrombin to obtain fibrin clots. cteph 59-64 fibrinogen beta chain Homo sapiens 9-19 19617247-0 2010 Influence of different hydroxyethyl starch (HES) formulations on fibrinogen measurement in HES-diluted plasma. Hydroxyethyl starch 23-42 fibrinogen beta chain Homo sapiens 65-75 19617247-0 2010 Influence of different hydroxyethyl starch (HES) formulations on fibrinogen measurement in HES-diluted plasma. Hydroxyethyl Starch Derivatives 44-47 fibrinogen beta chain Homo sapiens 65-75 19617247-0 2010 Influence of different hydroxyethyl starch (HES) formulations on fibrinogen measurement in HES-diluted plasma. Hydroxyethyl Starch Derivatives 91-94 fibrinogen beta chain Homo sapiens 65-75 20842854-0 2010 [Study on the selective removal of plasma low-density lipoprotein and fibrinogen by degraded carrageenan]. Carrageenan 93-104 fibrinogen beta chain Homo sapiens 70-80 20842854-1 2010 The selective removal of low density lipoprotein (LDL) and fibrinogen (Fib) by degraded carrageenan was studied by the present authors. Carrageenan 88-99 fibrinogen beta chain Homo sapiens 59-69 20842854-1 2010 The selective removal of low density lipoprotein (LDL) and fibrinogen (Fib) by degraded carrageenan was studied by the present authors. Carrageenan 88-99 fibrinogen beta chain Homo sapiens 71-74 20842854-5 2010 Then the selective removal of LDL/Fibrinogen by degraded carrageenan was studied. Carrageenan 57-68 fibrinogen beta chain Homo sapiens 34-44 20842854-6 2010 When molecular weight was about 10,000, pH was 5.10 and the concentration of degraded carrageenan was 800 mg/L, the average reduction percentages were 60.0% for total cholesterol(TC), 79.4% for LDL and very low-density lipoprotein (VLDL), and 93.8% for fibrinogen. Carrageenan 86-97 fibrinogen beta chain Homo sapiens 253-263 20842854-8 2010 So, degraded carrageenan was shown to be of good selectivity on plasma LDL/Fibrinogen apheresis. Carrageenan 13-24 fibrinogen beta chain Homo sapiens 75-85 22577418-7 2010 RESULTS: Cornus mas L. powder and lovastatin significantly decreased fibrinogen levels in comparison with high cholesterol group (P < 0.05). Lovastatin 34-44 fibrinogen beta chain Homo sapiens 69-79 20467806-6 2010 The thrombin-catalyzed degradation of fibrinogen, a physiological substrate for thrombin, was also inhibited by the CS containing both E unit and D unit. Chondroitin Sulfates 116-118 fibrinogen beta chain Homo sapiens 38-48 20676836-5 2010 In both groups studied, simvastatin significantly improved lipids, and reduced C-reactive protein and fibrinogen levels. Simvastatin 24-35 fibrinogen beta chain Homo sapiens 102-112 20206485-0 2010 Elevated plasma fibrinogen caused by inadequate alpha-linolenic acid intake can be reduced by replacing fat with canola-type rapeseed oil. alpha-Linolenic Acid 48-68 fibrinogen beta chain Homo sapiens 16-26 20206485-0 2010 Elevated plasma fibrinogen caused by inadequate alpha-linolenic acid intake can be reduced by replacing fat with canola-type rapeseed oil. canola-type rapeseed oil 113-137 fibrinogen beta chain Homo sapiens 16-26 20206485-7 2010 Docosahexaenoic acid (22:6n-3) in plasma phospholipids increased at low fibrinogen levels only. Docosahexaenoic Acids 0-20 fibrinogen beta chain Homo sapiens 72-82 20206485-7 2010 Docosahexaenoic acid (22:6n-3) in plasma phospholipids increased at low fibrinogen levels only. Phospholipids 41-54 fibrinogen beta chain Homo sapiens 72-82 20518532-0 2010 Assembling fibrinogen at air/water and solid/liquid interfaces using Langmuir and Langmuir-Blodgett films. Water 29-34 fibrinogen beta chain Homo sapiens 11-21 20518532-5 2010 The rate of formation of the fibril is the maximum for Fg with ZnCl(2). zncl 63-67 fibrinogen beta chain Homo sapiens 55-57 20518532-6 2010 Adsorption of Fg to surfaces coated with a neutral lipid, dimyristoylphosphatidylcholine (DMPC), and a cationic lipid, dioctadecyldimethylammonium bromide (DOMA), from a range of solution concentrations has been studied using a quartz crystal microbalance (QCM). Dimyristoylphosphatidylcholine 58-88 fibrinogen beta chain Homo sapiens 14-16 20404340-3 2010 Saturation mutagenesis of Trp(215) produces constructs featuring k(cat)/K(m) values for the hydrolysis of fibrinogen, protease-activated receptor PAR1, and protein C that span five orders of magnitude. Tryptophan 26-29 fibrinogen beta chain Homo sapiens 106-116 20714354-7 2010 Binding of lysin to the Bbeta chain was further localized to a region within the fibrinogen D fragment. bbeta 24-29 fibrinogen beta chain Homo sapiens 81-91 19617247-8 2010 RESULTS: On average and across all photo-optical methods, fibrinogen concentrations were overestimated, particularly with HES-200. Hydroxyethyl Starch Derivatives 122-125 fibrinogen beta chain Homo sapiens 58-68 19617247-13 2010 CONCLUSIONS: The study showed that all HES solutions more or less impaired the fibrinogen measurement with the photo-optical method. Hydroxyethyl Starch Derivatives 39-42 fibrinogen beta chain Homo sapiens 79-89 19617247-14 2010 In particular, overestimation with CLS-low may prevent timely fibrinogen replacement in major blood loss. Chlorine 35-38 fibrinogen beta chain Homo sapiens 62-72 19833622-0 2010 Photo-optical methods can lead to clinically relevant overestimation of fibrinogen concentration in plasma diluted with hydroxyethyl starch. Hydroxyethyl starch 120-139 fibrinogen beta chain Homo sapiens 72-82 27263451-1 2010 OBJECTIVE: We aimed to detect novel in vitro effects of clopidogrel on platelets by assessment of the following parameters: malondialdehyde, glutathione, nitrite, aggregation response, and expressions of P-selectin, fibrinogen, apolipoprotein A1, apolipoprotein B, and phosphatidylserine. Clopidogrel 56-67 fibrinogen beta chain Homo sapiens 216-226 19948255-5 2010 Fibrinogen activity and platelet adhesion on the polyurethane surfaces were found to decrease with increasing hydration time. Polyurethanes 49-61 fibrinogen beta chain Homo sapiens 0-10 19948255-6 2010 The findings suggest that water-induced enrichment of hydrophilic hard domains at the surface changes the local surface physical and chemical properties in a way that influences the conformation of fibrinogen, changing the availability of the platelet-binding sites in the protein. Water 26-31 fibrinogen beta chain Homo sapiens 198-208 19948255-7 2010 This work demonstrates that the hydrated polyurethane biomaterial interface is a complex and dynamic environment where the surface chemistry is changing, altering the activity of fibrinogen and affecting blood platelet adhesion. Polyurethanes 41-53 fibrinogen beta chain Homo sapiens 179-189 20538557-15 2010 Likewise, in the patients treated with 15 mg sibutramine, mean levels of TNF- alpha(p=0.01), fibrinogen (p= 0.02), and hsCRP (p= 0.04) decreased and adiponectin (p= 0.02) levels increased. sibutramine 45-56 fibrinogen beta chain Homo sapiens 93-103 20538557-17 2010 Also In addition, mean levels of adiponectin, TNF- alpha, fibrinogen and hs- CRP change with 19 months sibutramine treatment. sibutramine 103-114 fibrinogen beta chain Homo sapiens 58-68 20449889-0 2010 Carbon monoxide releasing molecule-2 increases fibrinogen-dependent coagulation kinetics but does not enhance prothrombin activity. Carbon Monoxide 0-15 fibrinogen beta chain Homo sapiens 47-57 20606742-7 2010 Two-dimensional electrophoresis (2-DE) using mini-gel was performed to analyse EV effects on the differents fibrinogen chains. .alpha.-Glutamylvaline 79-81 fibrinogen beta chain Homo sapiens 108-118 20383582-3 2010 The increased rate of fibrinogen turnover has been traced to generation of fibrin by labeling the polymers with glycine C14 ethyl esters in the presence of activated fibrin stabilizing factor. Polymers 98-106 fibrinogen beta chain Homo sapiens 22-32 20383582-3 2010 The increased rate of fibrinogen turnover has been traced to generation of fibrin by labeling the polymers with glycine C14 ethyl esters in the presence of activated fibrin stabilizing factor. glycine c14 ethyl esters 112-136 fibrinogen beta chain Homo sapiens 22-32 20383582-5 2010 Long chain saturated free fatty acids (FFA) exercise not only primary control over incorporation of Cl4 labeled amino acids into the fibrinogen structure but also activate the cascade sequence of reactions which convert fibrinogen into occlusive fibrin polymers. long chain saturated free fatty acids 0-37 fibrinogen beta chain Homo sapiens 133-143 20383582-5 2010 Long chain saturated free fatty acids (FFA) exercise not only primary control over incorporation of Cl4 labeled amino acids into the fibrinogen structure but also activate the cascade sequence of reactions which convert fibrinogen into occlusive fibrin polymers. long chain saturated free fatty acids 0-37 fibrinogen beta chain Homo sapiens 220-230 20383582-5 2010 Long chain saturated free fatty acids (FFA) exercise not only primary control over incorporation of Cl4 labeled amino acids into the fibrinogen structure but also activate the cascade sequence of reactions which convert fibrinogen into occlusive fibrin polymers. Fatty Acids, Nonesterified 39-42 fibrinogen beta chain Homo sapiens 133-143 20383582-5 2010 Long chain saturated free fatty acids (FFA) exercise not only primary control over incorporation of Cl4 labeled amino acids into the fibrinogen structure but also activate the cascade sequence of reactions which convert fibrinogen into occlusive fibrin polymers. Fatty Acids, Nonesterified 39-42 fibrinogen beta chain Homo sapiens 220-230 20216063-3 2010 The value of fibrinogen concentrate and prohemostatic drugs such as tranexamic acid and recombinant factor VIIa is also pointed out. Tranexamic Acid 68-83 fibrinogen beta chain Homo sapiens 13-23 20056447-11 2010 The HES-containing priming solution induced the largest decrease in the maximum clot firmness attributed to fibrinogen, from 13 +/- 1 mm (baseline) to 6 +/- 1 mm (p < 0.01 v baseline). Hydroxyethyl Starch Derivatives 4-7 fibrinogen beta chain Homo sapiens 108-118 20056447-12 2010 CONCLUSIONS: All studied priming solutions prolonged coagulation time and decreased clot formation, but the fibrinogen-limiting effect was the most profound for the HES-containing priming solution. Hydroxyethyl Starch Derivatives 165-168 fibrinogen beta chain Homo sapiens 108-118 20371668-11 2010 Higher hsCRP and fibrinogen were correlated with higher total and LDL cholesterol, and apolipoprotein B in youth with T1D, whereas higher fibrinogen was correlated with higher LDL and apolipoprotein B in controls. Cholesterol 70-81 fibrinogen beta chain Homo sapiens 17-27 19631515-9 2010 Compared to placebo, genistein significantly decreased fasting glucose and insulin, HOMA-IR, fibrinogen and homocysteine after 24 and 36 months of treatment. Genistein 21-30 fibrinogen beta chain Homo sapiens 93-103 20594474-7 2010 (2) There was positive correlation between the sEng level and systolic pressure, diastolic pressure, Fib, urine protein of 24 hours, serum creatinine (SCr); there was negative correlation between the sEng level and albumin (Alb) content, PT, estriol/creatinine (E/C) of 12-hour urine, fetal birth weight (all P<0.01). seng 47-51 fibrinogen beta chain Homo sapiens 101-104 20507587-9 2010 Pyk2 was tyrosine phosphorylated upon adhesion of dHL60 cells to plated fibrinogen in the presence of fMLP. Tyrosine 9-17 fibrinogen beta chain Homo sapiens 72-82 20520739-11 2010 CONCLUSIONS: Current vitamin D status was associated with tPA concentrations, and to a lesser degree with fibrinogen and D-dimer, suggesting that vitamin D status/intake may be important for maintaining antithrombotic homeostasis. Vitamin D 21-30 fibrinogen beta chain Homo sapiens 106-116 20442889-1 2010 Thin films terminated with oligo(ethylene glycol) (OEG) could be photochemically grafted onto ultrathin silicon carbide layers that were generated on silicon substrates via carbonization with acetylene at 820 degrees C. The OEG coating reduced the non-specific adsorption of fibrinogen on the substrates by 99.5% and remained resistant after storage in PBS for 4 weeks at 37 degrees C. oligo(ethylene glycol) 27-49 fibrinogen beta chain Homo sapiens 275-285 20442889-1 2010 Thin films terminated with oligo(ethylene glycol) (OEG) could be photochemically grafted onto ultrathin silicon carbide layers that were generated on silicon substrates via carbonization with acetylene at 820 degrees C. The OEG coating reduced the non-specific adsorption of fibrinogen on the substrates by 99.5% and remained resistant after storage in PBS for 4 weeks at 37 degrees C. Diglycolic acid 51-54 fibrinogen beta chain Homo sapiens 275-285 20442889-1 2010 Thin films terminated with oligo(ethylene glycol) (OEG) could be photochemically grafted onto ultrathin silicon carbide layers that were generated on silicon substrates via carbonization with acetylene at 820 degrees C. The OEG coating reduced the non-specific adsorption of fibrinogen on the substrates by 99.5% and remained resistant after storage in PBS for 4 weeks at 37 degrees C. ultrathin silicon carbide 94-119 fibrinogen beta chain Homo sapiens 275-285 20642000-4 2004 The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3. Arginine 21-24 fibrinogen beta chain Homo sapiens 134-144 20642000-4 2004 The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3. Glycine 25-28 fibrinogen beta chain Homo sapiens 134-144 20642000-4 2004 The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3. Aspartic Acid 29-32 fibrinogen beta chain Homo sapiens 134-144 27263451-6 2010 In both groups, clopidogrel significantly reduced aggregation and expression of fibrinogen, but it elevated nitrite levels. Clopidogrel 16-27 fibrinogen beta chain Homo sapiens 80-90 20642906-11 2010 CONCLUSIONS: Bezafibrate treatment was a safe treatment and reduced fibrinogen levels in patients with STEAMI and hyperfibrinogenemia. Bezafibrate 13-24 fibrinogen beta chain Homo sapiens 68-78 20153048-1 2010 This work reports on how incorporation of silica nanocages into poly(urethane) copolymers (PU) affects conformational orientations of adsorbed fibrinogen and how different surfaces subsequently influenced HeLa cell attachment and proliferation. Silicon Dioxide 42-48 fibrinogen beta chain Homo sapiens 143-153 20153048-1 2010 This work reports on how incorporation of silica nanocages into poly(urethane) copolymers (PU) affects conformational orientations of adsorbed fibrinogen and how different surfaces subsequently influenced HeLa cell attachment and proliferation. poly(urethane) copolymers 64-89 fibrinogen beta chain Homo sapiens 143-153 20153048-1 2010 This work reports on how incorporation of silica nanocages into poly(urethane) copolymers (PU) affects conformational orientations of adsorbed fibrinogen and how different surfaces subsequently influenced HeLa cell attachment and proliferation. Plutonium 91-93 fibrinogen beta chain Homo sapiens 143-153 20153048-4 2010 As on the bare SiO(2) control surface, fibrinogen molecules adsorbed on top of the hard nanocages mainly took the dominant trinodular structures in monomeric and dimeric forms. Silicon Dioxide 15-21 fibrinogen beta chain Homo sapiens 39-49 20348406-4 2010 Sheep antihuman fibrinogen/horseradish peroxidase conjugate was used for detection, with 3,3",5,5"-tetramethylbenzidine as substrate. 3,3',5,5'-tetramethylbenzidine 89-119 fibrinogen beta chain Homo sapiens 16-26 19919044-0 2010 Effect of surface morphology and charge on the amount and conformation of fibrinogen adsorbed onto alginate/chitosan microcapsules. Alginates 99-107 fibrinogen beta chain Homo sapiens 74-84 19919044-0 2010 Effect of surface morphology and charge on the amount and conformation of fibrinogen adsorbed onto alginate/chitosan microcapsules. Chitosan 108-116 fibrinogen beta chain Homo sapiens 74-84 20129774-2 2010 Addition of fibrinogen to a solution of Au NPs (average diameter: 56 nm) led to ready conjugation, forming Fib-Au NPs through electrostatic and hydrophobic interactions. Gold 40-42 fibrinogen beta chain Homo sapiens 12-22 20129774-2 2010 Addition of fibrinogen to a solution of Au NPs (average diameter: 56 nm) led to ready conjugation, forming Fib-Au NPs through electrostatic and hydrophobic interactions. Gold 40-42 fibrinogen beta chain Homo sapiens 107-110 20219762-0 2010 Associations of toenail selenium levels with inflammatory biomarkers of fibrinogen, high-sensitivity c-reactive protein, and interleukin-6: The CARDIA Trace Element Study. Selenium 24-32 fibrinogen beta chain Homo sapiens 72-82 20097190-6 2010 RESULTS: Multi-adjusted regression analyses revealed that plasma n-3 fatty acids were inversely associated with CRP, IL-6 and TNF-alpha; plasma n-6 fatty acids were inversely associated with CRP, IL-6 and fibrinogen; monounsaturated fatty acids were inversely associated with CRP and IL-6 (all p-values<0.05). Fatty Acids, Omega-6 144-159 fibrinogen beta chain Homo sapiens 205-215 20045297-8 2010 For thicker PNIPAAm-grafted surface with thickness of 38.1 nm, the adsorption results of three proteins (HSA, fibrinogen, and lysozyme) with different sizes and charges indicate that the PNIPAAm-modified surface exhibits a size-sensitive property of protein adsorption. poly-N-isopropylacrylamide 12-19 fibrinogen beta chain Homo sapiens 110-120 20136824-2 2010 Adhesion of PLTs from healthy controls (CON), SCD individuals (SCD) and SCD patients on hydroxycarbamide (SCDHC) to fibrinogen (FB) was compared using static adhesion assays. Hydroxyurea 88-104 fibrinogen beta chain Homo sapiens 116-126 22577405-7 2010 RESULTS: Cornus mas L. powder and lovastatin significantly decreased fibrinogen levels in comparison with high cholesterol group (P < 0.05). Lovastatin 34-44 fibrinogen beta chain Homo sapiens 69-79 19703819-3 2010 Adenosine diphosphate (ADP)-induced platelet aggregation and the expressions of glycoprotein (Gp) IIb, GpIIIa, P-selectin, and fibrinogen (Fg) and low-density lipoprotein (LDL) binding to platelets were assessed preoperatively and at postoperative days 7, 90, and 180. Adenosine Diphosphate 0-21 fibrinogen beta chain Homo sapiens 127-137 19703819-3 2010 Adenosine diphosphate (ADP)-induced platelet aggregation and the expressions of glycoprotein (Gp) IIb, GpIIIa, P-selectin, and fibrinogen (Fg) and low-density lipoprotein (LDL) binding to platelets were assessed preoperatively and at postoperative days 7, 90, and 180. Adenosine Diphosphate 23-26 fibrinogen beta chain Homo sapiens 127-137 20045297-8 2010 For thicker PNIPAAm-grafted surface with thickness of 38.1 nm, the adsorption results of three proteins (HSA, fibrinogen, and lysozyme) with different sizes and charges indicate that the PNIPAAm-modified surface exhibits a size-sensitive property of protein adsorption. poly-N-isopropylacrylamide 187-194 fibrinogen beta chain Homo sapiens 110-120 20097132-4 2010 Fibrinogen and cU50980omponents of the complex DMEM cell culture medium induced the mga transcription rate. dmem cell culture medium 47-71 fibrinogen beta chain Homo sapiens 0-10 20002787-8 2010 Fibrinopeptides A and B (FPA and FPB, respectively) were released after fibrinogen cleavage by L-FCN-MASPs complexes captured on N-acetylcysteine-Sepharose. Acetylcysteine 129-145 fibrinogen beta chain Homo sapiens 72-82 20002787-8 2010 Fibrinopeptides A and B (FPA and FPB, respectively) were released after fibrinogen cleavage by L-FCN-MASPs complexes captured on N-acetylcysteine-Sepharose. Sepharose 146-155 fibrinogen beta chain Homo sapiens 72-82 20097132-5 2010 The attachment of mga mutants to immobilized human matrix proteins (collagen type I, fibronectin, keratin, laminin) and serum proteins (albumin, fibrinogen) was consistently reduced. Melengestrol Acetate 18-21 fibrinogen beta chain Homo sapiens 145-155 20213795-1 2010 OBJECTIVES/HYPOTHESIS: This study"s aim was to verify whether, in patients affected by sudden sensorineural hearing loss (SSHL) with high plasmatic levels of low-density-lipoprotein (LDL) cholesterol and/or fibrinogen, the therapeutic approach with a single selective plasmapheresis (HELP-apheresis) followed by 10 days of standard treatment (glycerol and dexamethazone) is more effective than 10 days of standard treatment. Cholesterol 188-199 fibrinogen beta chain Homo sapiens 207-217 20440247-8 2010 RESULTS: Five months of simvastatin treatment showed a decrease in lipid levels, concomitantly with reduction in PMNL priming, PMNL apoptosis, fibrinogen and CRP levels. Simvastatin 24-35 fibrinogen beta chain Homo sapiens 143-153 20179170-10 2010 In the unadjusted analysis, SUA levels correlated with PWV, CRP, fibrinogen and homocysteine. sua 28-31 fibrinogen beta chain Homo sapiens 65-75 20113253-2 2010 Results of in vitro studies demonstrated that fibrinogen can bind to apolipoprotein(a) [apo(a)] component of lipoprotein(a) [Lp(a)] through both lysine-sensitive and lysine-insensitive mechanisms. Lysine 145-151 fibrinogen beta chain Homo sapiens 46-56 19945746-4 2010 Fibrinogen adsorption and platelets adhesion on these topographic surfaces were quantified by enzyme linked immunosorbent assay (ELISA) and lactate dehydrogenase (LDH) assay respectively, while the activation of platelets was quantified by flow cytometric analysis using fluorescein isothiocyanate (FITC) tagging. Fluorescein-5-isothiocyanate 271-297 fibrinogen beta chain Homo sapiens 0-10 19945746-4 2010 Fibrinogen adsorption and platelets adhesion on these topographic surfaces were quantified by enzyme linked immunosorbent assay (ELISA) and lactate dehydrogenase (LDH) assay respectively, while the activation of platelets was quantified by flow cytometric analysis using fluorescein isothiocyanate (FITC) tagging. Fluorescein-5-isothiocyanate 299-303 fibrinogen beta chain Homo sapiens 0-10 20113253-2 2010 Results of in vitro studies demonstrated that fibrinogen can bind to apolipoprotein(a) [apo(a)] component of lipoprotein(a) [Lp(a)] through both lysine-sensitive and lysine-insensitive mechanisms. Lysine 166-172 fibrinogen beta chain Homo sapiens 46-56 19653113-6 2010 Fibrinogen, dialysate/plasma creatinine ratio and folic acid were found to be the independent predictors of Hcy level (P < 0.001; P < 0.01; P < 0.05, respectively). Homocysteine 108-111 fibrinogen beta chain Homo sapiens 0-10 19686810-0 2010 Effect of quercetin on platelet spreading on collagen and fibrinogen and on multiple platelet kinases. Quercetin 10-19 fibrinogen beta chain Homo sapiens 58-68 19653113-9 2010 CONCLUSION: Hyperhomocysteinemia incidence seems high among PD patients and despite significant relationship between fibrinogen and Hcy in our study, it is essential to evaluate the link between Hcy levels and inflammation. Homocysteine 132-135 fibrinogen beta chain Homo sapiens 117-127 20025644-7 2010 After further adjustment for field center, BMI, smoking, education, systolic blood pressure, diabetes, antihypertensive medication use, total and HDL cholesterol, and CRP, significant positive relationships between fibrinogen and incidence of CAC remained for the total cohort longitudinally (P-trend = 0.037), but not cross-sectionally (P-trend = 0.147). Cholesterol 150-161 fibrinogen beta chain Homo sapiens 215-225 20510102-4 2010 Fibrinogen and its constituent were analyzed by Western blot with nonreducing 4%-20% SDS-polyacrylamide gel electrophoresis (PAGE). Sodium Dodecyl Sulfate 85-88 fibrinogen beta chain Homo sapiens 0-10 20510102-4 2010 Fibrinogen and its constituent were analyzed by Western blot with nonreducing 4%-20% SDS-polyacrylamide gel electrophoresis (PAGE). polyacrylamide 89-103 fibrinogen beta chain Homo sapiens 0-10 19903699-3 2010 We have investigated the effect of structural modifications induced by metal ion catalyzed oxidation of fibrinogen on its binding capacity to glycoprotein IIb/IIIa (GpIIb/IIIa) and human platelets. Metals 71-76 fibrinogen beta chain Homo sapiens 104-114 19700161-7 2010 Among non-smokers, serum cotinine levels were independently positively associated with CRP, fibrinogen, factor VIII, VWF and t-PA and inversely associated with albumin, after adjustment for age, gender, social and behavioural factors. Cotinine 25-33 fibrinogen beta chain Homo sapiens 92-102 19903699-5 2010 Dityrosine formation on oxidized fibrinogen were detected spectrophotometrically. dityrosine 0-10 fibrinogen beta chain Homo sapiens 33-43 19903699-8 2010 RESULTS: Oxidatively modified fibrinogen showed less binding activity than native fibrinogen to GpIIb/IIIa coated micro beads and human platelets whereas slightly higher binding capacity to ADP induced stimulated platelets. Adenosine Diphosphate 190-193 fibrinogen beta chain Homo sapiens 30-40 19903699-9 2010 Formation of di-tyrosines in the amino acid side chains of fibrinogen were observed upon oxidation. dityrosine 13-25 fibrinogen beta chain Homo sapiens 59-69 19903699-10 2010 Decreased binding capacity of oxidized fibrinogen correlated with intensities of dityrosine formation. dityrosine 81-91 fibrinogen beta chain Homo sapiens 39-49 19482838-6 2009 Valproate causes decreased factor VII levels, platelet count, factor VIII, Protein C, fibrinogen, and increased lipoprotein (a) levels. Valproic Acid 0-9 fibrinogen beta chain Homo sapiens 86-96 19854626-1 2010 Thick matrices of fibrinogen with incorporation of a matrix metalloproteinase inhibitor were covalently bonded on functionalized silicon surfaces using an ethyl-3-dimethyl-aminopropyl-carbodiimide and N-hydroxy-succinimide affinity ligand coupling chemistry. Silicon 129-136 fibrinogen beta chain Homo sapiens 18-28 19854626-1 2010 Thick matrices of fibrinogen with incorporation of a matrix metalloproteinase inhibitor were covalently bonded on functionalized silicon surfaces using an ethyl-3-dimethyl-aminopropyl-carbodiimide and N-hydroxy-succinimide affinity ligand coupling chemistry. ethyl-3-dimethyl-aminopropyl-carbodiimide 155-196 fibrinogen beta chain Homo sapiens 18-28 19235218-8 2010 Aluminum deposited as either a constant-composition film or as part of a binary library consistently adsorbed the least amount of albumin and fibrinogen, with alumina-enrichment of the surface oxide correlating with this adsorption. Aluminum 0-8 fibrinogen beta chain Homo sapiens 142-152 20181055-5 2010 Blocking NFkappaB with MG-132 also inhibited pro-coagulant activation of monocytes by fibrinogen. benzyloxycarbonylleucyl-leucyl-leucine aldehyde 23-29 fibrinogen beta chain Homo sapiens 86-96 20641630-11 2004 A peptide sequence consisting of Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3. arginyl-glycyl-aspartic acid 33-44 fibrinogen beta chain Homo sapiens 146-156 20641746-11 2004 A peptide sequence consisting of Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3. arginyl-glycyl-aspartic acid 33-44 fibrinogen beta chain Homo sapiens 146-156 19857568-14 2010 Nitrotyrosine levels were significantly lower in fibrinogen than total plasma protein, with no difference between patients and controls. 3-nitrotyrosine 0-13 fibrinogen beta chain Homo sapiens 49-59 19857568-15 2010 Chlorotyrosine levels in fibrinogen (but not total protein) were significantly higher for the post myocardial patients. 3-chlorotyrosine 0-14 fibrinogen beta chain Homo sapiens 25-35 20024308-1 2010 Selective chemical modification of a gold nano-cavity array is achieved via nanoscale templating to create fibrinogen patterned cavities with a polyethylene glycol modified top surface. Polyethylene Glycols 144-163 fibrinogen beta chain Homo sapiens 107-117 20038174-1 2010 The electrochemically induced desorption of Oregon green labeled fibrinogen layers from clean gold surfaces at negative potentials has been probed using capacitance, fluorescence microscopy, and atomic force microscopy. 2-(2,7-difluoro-6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid 44-56 fibrinogen beta chain Homo sapiens 65-75 20038174-6 2010 Significantly, SDS-PAGE analysis indicates that the adsorption-desorption cycle dramatically effects the protein structure, with the electrochemically desorbed fibrinogen showing extensive fragmentation compared to native protein. Sodium Dodecyl Sulfate 15-18 fibrinogen beta chain Homo sapiens 160-170 21109498-11 2010 Trimix protects divers from a reduction in the amount of platelets, fibrinogen and factor XII in the course of these exposures. trimix 0-6 fibrinogen beta chain Homo sapiens 68-78 21182780-7 2010 RESULTS: In total about two-thirds of the 81 arginines of human fibrinogen were found to be susceptible to citrullination by the human PAD2, the human PAD4 or the rabbit PAD2 enzymes. Arginine 45-54 fibrinogen beta chain Homo sapiens 64-74 19783413-3 2010 Fibrinogen molecules were covalently bound to Si(3)N(4) AFM tips, previously modified with 3-aminopropyl-dimethyl-ethoxysilane, through a homobifunctional poly(ethylene glycol) linker bearing two hydroxysulfosuccinimide esters. si(3)n 46-52 fibrinogen beta chain Homo sapiens 0-10 19783413-3 2010 Fibrinogen molecules were covalently bound to Si(3)N(4) AFM tips, previously modified with 3-aminopropyl-dimethyl-ethoxysilane, through a homobifunctional poly(ethylene glycol) linker bearing two hydroxysulfosuccinimide esters. (3-aminopropyl)dimethylethoxysilane 91-126 fibrinogen beta chain Homo sapiens 0-10 19783413-3 2010 Fibrinogen molecules were covalently bound to Si(3)N(4) AFM tips, previously modified with 3-aminopropyl-dimethyl-ethoxysilane, through a homobifunctional poly(ethylene glycol) linker bearing two hydroxysulfosuccinimide esters. poly( 155-160 fibrinogen beta chain Homo sapiens 0-10 19783413-3 2010 Fibrinogen molecules were covalently bound to Si(3)N(4) AFM tips, previously modified with 3-aminopropyl-dimethyl-ethoxysilane, through a homobifunctional poly(ethylene glycol) linker bearing two hydroxysulfosuccinimide esters. Ethylene Glycol 160-175 fibrinogen beta chain Homo sapiens 0-10 19783413-3 2010 Fibrinogen molecules were covalently bound to Si(3)N(4) AFM tips, previously modified with 3-aminopropyl-dimethyl-ethoxysilane, through a homobifunctional poly(ethylene glycol) linker bearing two hydroxysulfosuccinimide esters. hydroxysulfosuccinimide esters 196-226 fibrinogen beta chain Homo sapiens 0-10 20720426-6 2010 The parameters with positive correlations with NIHSS were fibrinogen (r = 0.270, p = 0.019), fasting glucose (r = 0.358, p = 0.008) and HOMA (r = 0.286, p = 0.013). nihss 47-52 fibrinogen beta chain Homo sapiens 58-68 20534188-6 2010 The adsorption of fibrinogen and lysozyme to the modified surfaces was greatly reduced compared to the unmodified surfaces, and adsorption decreased with increasing poly(MPC) chain length. poly(mpc) 165-174 fibrinogen beta chain Homo sapiens 18-28 20204259-0 2010 [Effect of a high saturated fatty acids load on serum concentrations of C-reactive protein, alpha1-antitrypsin, fibrinogen and alpha1-acid glycoprotein in obese women]. Fatty Acids 18-39 fibrinogen beta chain Homo sapiens 112-122 20863217-9 2010 CONCLUSION: l-Carnitine supplement reduces serum CRP, a marker of systemic inflammation, and plasma fibrinogen, an inflammation-related coagulation factor, in hemodialysis patients. Carnitine 12-23 fibrinogen beta chain Homo sapiens 100-110 21381352-7 2010 During ingramon therapy, the content of hs-CRP and fibrinogen was considerably lower on days 1, 2, and 7 after CS than in the control group; this trend persisted a month after surgery; there was also a reduction in MCP-1 levels within the first 24 hours after initiation of therapy. Cesium 111-113 fibrinogen beta chain Homo sapiens 40-61 20641262-5 2004 The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3. Arginine 21-24 fibrinogen beta chain Homo sapiens 134-144 20641262-5 2004 The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3. Glycine 25-28 fibrinogen beta chain Homo sapiens 134-144 20641262-5 2004 The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3. Aspartic Acid 29-32 fibrinogen beta chain Homo sapiens 134-144 20641458-5 2004 The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3. Arginine 21-24 fibrinogen beta chain Homo sapiens 134-144 20641458-5 2004 The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3. Glycine 25-28 fibrinogen beta chain Homo sapiens 134-144 20641458-5 2004 The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3. Aspartic Acid 29-32 fibrinogen beta chain Homo sapiens 134-144 20641917-5 2004 The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3. Arginine 21-24 fibrinogen beta chain Homo sapiens 134-144 20641917-5 2004 The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3. Glycine 25-28 fibrinogen beta chain Homo sapiens 134-144 20641917-5 2004 The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3. Aspartic Acid 29-32 fibrinogen beta chain Homo sapiens 134-144 19786866-11 2009 Thus, high aerobic power as assessed by maximal oxygen consumption appears to be associated with lower plasma viscosity and lower plasma fibrinogen. Oxygen 48-54 fibrinogen beta chain Homo sapiens 137-147 20007717-4 2010 The binding site for Fbl in fibrinogen was localized to the extreme C terminus of the fibrinogen gamma-chain at the same site recognized by ClfA. clfa 140-144 fibrinogen beta chain Homo sapiens 28-38 20007717-11 2010 Fbl variant proteins with alanine substitutions in key residues had reduced affinities for fibrinogen. Alanine 26-33 fibrinogen beta chain Homo sapiens 91-101 20007717-12 2010 Thus Fbl and ClfA bind the same site in fibrinogen by similar mechanisms. clfa 13-17 fibrinogen beta chain Homo sapiens 40-50 22282689-5 2010 Sulodexide inhibits aggregation and adhesion of platelets at the level of the vascular wall, reduces plasma fibrinogen concentrations, reduces plasminogen activator inhibitor-1, and increases tissue plasminogen activator, as well as systemic fibrinolytic and thrombolytic activity, thereby demonstrating efficacy in the treatment of thromboembolic disease. glucuronyl glucosamine glycan sulfate 0-10 fibrinogen beta chain Homo sapiens 108-118 19822319-0 2010 Nanoparticles of nickel oxide and nickel hydroxide using lyophilisomes of fibrinogen as template. nickel monoxide 17-29 fibrinogen beta chain Homo sapiens 74-84 19822319-0 2010 Nanoparticles of nickel oxide and nickel hydroxide using lyophilisomes of fibrinogen as template. nickel hydroxide 34-50 fibrinogen beta chain Homo sapiens 74-84 19822319-2 2010 Reduction of the lyophilisomes of the nickel-fibrinogen complex coated on solid substrates and subsequent heating showed formation of nickel hydroxide and finally nickel oxide. nickel hydroxide 134-150 fibrinogen beta chain Homo sapiens 45-55 19822319-2 2010 Reduction of the lyophilisomes of the nickel-fibrinogen complex coated on solid substrates and subsequent heating showed formation of nickel hydroxide and finally nickel oxide. nickel monoxide 163-175 fibrinogen beta chain Homo sapiens 45-55 19693654-1 2010 Controllable bio-synthetic polymeric hydrogels made from fibrinogen-poly(ethylene glycol) adducts have been successfully employed in tissue engineering. Polyethylene Glycols 68-89 fibrinogen beta chain Homo sapiens 57-67 19693654-2 2010 The structural consequences of PEG conjugation to fibrinogen (i.e., PEGylation) in such a hydrogel network are not fully understood. Polyethylene Glycols 31-34 fibrinogen beta chain Homo sapiens 50-60 19693654-3 2010 The current investigation details the structural alterations caused to the reduced fibrinogen polypeptides by the covalent attachment of linear or branched PEG chains. Polyethylene Glycols 156-159 fibrinogen beta chain Homo sapiens 83-93 20129384-3 2009 Fibrinogen/LDL apheresis improves cochlear blood flow by acutely decreasing plasma cholesterol and fibrinogen. Cholesterol 83-94 fibrinogen beta chain Homo sapiens 0-10 20641584-4 2004 The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3 and alphavbeta5. Arginine 21-24 fibrinogen beta chain Homo sapiens 134-144 20641584-4 2004 The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3 and alphavbeta5. Glycine 25-28 fibrinogen beta chain Homo sapiens 134-144 20641584-4 2004 The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3 and alphavbeta5. Aspartic Acid 29-32 fibrinogen beta chain Homo sapiens 134-144 19809304-1 2009 We found a heterozygous dysfibrinogenemia caused by the substitution of BbetaGly15Cys and designated it fibrinogen Hamamatsu II (H-II). bbetagly15cys 72-85 fibrinogen beta chain Homo sapiens 27-37 19809304-4 2009 Fibrinogen was purified from the propositus" and normal control plasma by immunoaffinity chromatography and was used for the following experiments: sodium dodecyl sulfate-polyacrylamide gel electrophoresis, fibrin polymerization, scanning electron microscopic observation of fibrin clot and fibers, clot lysis, and tissue-type plasminogen activator-mediated plasminogen activation. Sodium Dodecyl Sulfate 148-170 fibrinogen beta chain Homo sapiens 0-10 19809304-4 2009 Fibrinogen was purified from the propositus" and normal control plasma by immunoaffinity chromatography and was used for the following experiments: sodium dodecyl sulfate-polyacrylamide gel electrophoresis, fibrin polymerization, scanning electron microscopic observation of fibrin clot and fibers, clot lysis, and tissue-type plasminogen activator-mediated plasminogen activation. polyacrylamide 171-185 fibrinogen beta chain Homo sapiens 0-10 19804533-12 2009 CONCLUSIONS: These PK findings confirm a rapid increase in plasma fibrinogen levels after infusion with FCH. fluorocholine 104-107 fibrinogen beta chain Homo sapiens 66-76 19949684-4 2009 Fibrinogen Yecheon has a de novo heterozygous point mutation of FGG resulting in gamma Met310Thr and subsequent extra N-glycosylation at gamma Asn308. Nitrogen 118-119 fibrinogen beta chain Homo sapiens 0-10 19949684-5 2009 Extra N-glycosylated fibrinogen is considered a main inhibitor of normal fibrinogen activity. Nitrogen 6-7 fibrinogen beta chain Homo sapiens 21-31 19949684-5 2009 Extra N-glycosylated fibrinogen is considered a main inhibitor of normal fibrinogen activity. Nitrogen 6-7 fibrinogen beta chain Homo sapiens 73-83 19687019-11 2009 Short-term exposure to O(3) was associated with increased, and SO(2) with decreased, fibrinogen levels. Ozone 23-27 fibrinogen beta chain Homo sapiens 85-95 20001999-2 2009 Three months initial therapy with rosiglitazone significantly reduced values of HbA1C, fibrinogen and CRP but not uric acid in prediabetic patients.Rosiglitazone initial three months therapy significantly reduced HbA1C, fibrinogen and uric acid, but not CRP in diabetic patients. Rosiglitazone 34-47 fibrinogen beta chain Homo sapiens 87-97 20001999-2 2009 Three months initial therapy with rosiglitazone significantly reduced values of HbA1C, fibrinogen and CRP but not uric acid in prediabetic patients.Rosiglitazone initial three months therapy significantly reduced HbA1C, fibrinogen and uric acid, but not CRP in diabetic patients. Rosiglitazone 34-47 fibrinogen beta chain Homo sapiens 220-230 20001999-2 2009 Three months initial therapy with rosiglitazone significantly reduced values of HbA1C, fibrinogen and CRP but not uric acid in prediabetic patients.Rosiglitazone initial three months therapy significantly reduced HbA1C, fibrinogen and uric acid, but not CRP in diabetic patients. Rosiglitazone 148-161 fibrinogen beta chain Homo sapiens 220-230 19759246-4 2009 Fibrinogen synthesis was determined in 3 separate occasions from the incorporation of l[(2)H(5)]phenylalanine (43 mg/kg body weight) in 8 young (21-35 y) and 8 elderly (>60 y) participants following the ingestion of water (control), a complete liquid meal (15% protein, 30% fat, and 55% carbohydrate), or only the protein component of the meal. l[(2)h(5)]phenylalanine 86-109 fibrinogen beta chain Homo sapiens 0-10 20015321-0 2009 Enhanced post-clopidogrel platelet reactivity in diabetic patients is independently related to plasma fibrinogen level but not to glycemic control. Clopidogrel 14-25 fibrinogen beta chain Homo sapiens 102-112 19556113-9 2009 This observation opposes expectations based on DLVO arguments, pointing to localized electrostatic attractions and hydration effects to drive silica-fibrinogen adhesion. Silicon Dioxide 142-148 fibrinogen beta chain Homo sapiens 149-159 19631267-2 2009 Recent small studies report that fibrinogen oxidative modifications, specifically tyrosine residue nitration, can occur in inflammatory states and may modify fibrinogen function. Tyrosine 82-90 fibrinogen beta chain Homo sapiens 33-43 19593117-4 2009 The test is not affected by other clotting factors is assured by the use of a phospholipid-free animal plasma, which provides excess factor V, fibrinogen and prothrombin. Phospholipids 78-90 fibrinogen beta chain Homo sapiens 143-153 19631267-2 2009 Recent small studies report that fibrinogen oxidative modifications, specifically tyrosine residue nitration, can occur in inflammatory states and may modify fibrinogen function. Tyrosine 82-90 fibrinogen beta chain Homo sapiens 158-168 19719165-6 2009 The cross-linked PVPON(Alk) multilayers (assembled on silica particles) were low-fouling to a range of proteins, including fibrinogen, lysozyme, immunoglobulin G, and bovine serum albumin. Povidone 17-22 fibrinogen beta chain Homo sapiens 123-133 19595454-3 2009 Human marrow stromal cells (hMSCs) were singularly encapsulated in agarose capsules containing the immobilized matrix molecules, fibronectin and fibrinogen to ameliorate cell-matrix survival signals. Sepharose 67-74 fibrinogen beta chain Homo sapiens 145-155 19138314-6 2009 RESULTS: Plasma levels of fibrinogen, d-dimer, vWF, TF and PAI-1 increased significantly after treatment with LT(4) for 1 year. Thyroxine 110-115 fibrinogen beta chain Homo sapiens 26-36 19798675-4 2009 PP2% was directly subjected to MALDI-MS PMF and FN and Fb were assigned, suggesting it was formed by co-precipitation of the two proteins. pp2 0-3 fibrinogen beta chain Homo sapiens 55-57 19798675-7 2009 The soluble fraction of the PEG 2-4% precipitate (PS4%), analyzed by non-denaturing 2-DE and MALDI-MS PMF, contained C4b-binding protein and its complex with complement C4, low-density lipoproteins, IgM, and complement C1 subcomponent q, together with Fb, FN, and their oligomers. Polyethylene Glycols 28-31 fibrinogen beta chain Homo sapiens 252-254 18683221-6 2009 The adsorption of ovine fibrinogen onto PMA-modified surfaces was reduced relative to unmodified surfaces, and in vitro ovine blood contact through a rocking test revealed marked reductions in platelet deposition and bulk phase platelet activation relative to unmodified TiAl6V4 and polystyrene controls. Polystyrenes 283-294 fibrinogen beta chain Homo sapiens 24-34 19679667-8 2009 For those with diabetes, increased serum phosphate (RH 1.2; 95% CI 1.1 to 1.4), along with decreased albumin, increased C-reactive protein and fibrinogen, and lower SBP, was associated with risk for PVD procedures. Phosphates 41-50 fibrinogen beta chain Homo sapiens 143-153 19138314-7 2009 Serum FT(4) was a significant predictor of increased fibrinogen, vWF and PAI-1 levels, when the data was controlled for age and BMI. ft(4) 6-11 fibrinogen beta chain Homo sapiens 53-63 19809847-0 2009 Fibrinogen-dependent signaling in microvascular erythrocyte function: implications on nitric oxide efflux. Nitric Oxide 86-98 fibrinogen beta chain Homo sapiens 0-10 19715411-4 2009 Alcohol affects several biochemical factors that have potential cardioprotective benefits, including lipids, platelet aggregation, fibrinogen, tissue-plasminogen activator, plasminogen-activator inhibitor and omega-3 fatty acids. Alcohols 0-7 fibrinogen beta chain Homo sapiens 131-141 19936338-0 2009 Iodine-125-fibrinogen kinetics in the rabbit arterial wall. Iodine 0-6 fibrinogen beta chain Homo sapiens 11-21 19415230-9 2009 In conclusion, the results in the present study, when compared to earlier SBF studies without proteins, showed that fibrinogen stimulates calcium phosphates formation. Calcium Phosphates 138-156 fibrinogen beta chain Homo sapiens 116-126 19809847-5 2009 Our results showed, when compared with control aliquots, that the presence of fibrinogen modulates the NO mobilization in erythrocytes by (1) decreasing erythrocyte NO efflux levels (P < 0.001); (2) increasing levels of intraerythrocytic NO oxidative metabolites, namely, nitrite (P < 0.0001) and nitrate (P < 0.0001); and (3) enhancing the formation of GSNO (P < 0.001). Nitrites 275-282 fibrinogen beta chain Homo sapiens 78-88 19809847-5 2009 Our results showed, when compared with control aliquots, that the presence of fibrinogen modulates the NO mobilization in erythrocytes by (1) decreasing erythrocyte NO efflux levels (P < 0.001); (2) increasing levels of intraerythrocytic NO oxidative metabolites, namely, nitrite (P < 0.0001) and nitrate (P < 0.0001); and (3) enhancing the formation of GSNO (P < 0.001). Nitrates 303-310 fibrinogen beta chain Homo sapiens 78-88 19809847-5 2009 Our results showed, when compared with control aliquots, that the presence of fibrinogen modulates the NO mobilization in erythrocytes by (1) decreasing erythrocyte NO efflux levels (P < 0.001); (2) increasing levels of intraerythrocytic NO oxidative metabolites, namely, nitrite (P < 0.0001) and nitrate (P < 0.0001); and (3) enhancing the formation of GSNO (P < 0.001). S-Nitrosoglutathione 363-367 fibrinogen beta chain Homo sapiens 78-88 19397901-0 2009 Glycolaldehyde induces fibrinogen post-translational modification, delay in clotting and resistance to enzymatic digestion. glycolaldehyde 0-14 fibrinogen beta chain Homo sapiens 23-33 19397901-5 2009 We also aimed to evaluate the role of fibrinogen in GA-induced haemostatic dysfunction. glycolaldehyde 52-54 fibrinogen beta chain Homo sapiens 38-48 19397901-8 2009 An SDS-PAGE was run to check the presence of cross-linking between fibrinogen chains. Sodium Dodecyl Sulfate 3-6 fibrinogen beta chain Homo sapiens 67-77 19397901-14 2009 The data presented herein indicate that GA causes post-translational modification of lysine and arginine residues, which are central to many events involving fibrinogen to fibrin conversion, as well as to fibrinolysis. glycolaldehyde 40-42 fibrinogen beta chain Homo sapiens 158-168 19397901-14 2009 The data presented herein indicate that GA causes post-translational modification of lysine and arginine residues, which are central to many events involving fibrinogen to fibrin conversion, as well as to fibrinolysis. Lysine 85-91 fibrinogen beta chain Homo sapiens 158-168 19397901-14 2009 The data presented herein indicate that GA causes post-translational modification of lysine and arginine residues, which are central to many events involving fibrinogen to fibrin conversion, as well as to fibrinolysis. Arginine 96-104 fibrinogen beta chain Homo sapiens 158-168 19555809-9 2009 In addition, we found simvastatin-induced increases in aspartate transaminase and fibrinogen to be attenuated by L-arginine as compared to placebo. Simvastatin 22-33 fibrinogen beta chain Homo sapiens 82-92 19422014-1 2009 The influence of the surface fraction of OH groups on fibrinogen (FG) adsorption is investigated in copolymers of ethyl acrylate and hydroxy ethylacrylate. copolymers 100-110 fibrinogen beta chain Homo sapiens 54-64 19422014-1 2009 The influence of the surface fraction of OH groups on fibrinogen (FG) adsorption is investigated in copolymers of ethyl acrylate and hydroxy ethylacrylate. copolymers 100-110 fibrinogen beta chain Homo sapiens 66-68 19422014-1 2009 The influence of the surface fraction of OH groups on fibrinogen (FG) adsorption is investigated in copolymers of ethyl acrylate and hydroxy ethylacrylate. ethyl acrylate 114-128 fibrinogen beta chain Homo sapiens 54-64 19422014-1 2009 The influence of the surface fraction of OH groups on fibrinogen (FG) adsorption is investigated in copolymers of ethyl acrylate and hydroxy ethylacrylate. ethyl acrylate 114-128 fibrinogen beta chain Homo sapiens 66-68 19422014-1 2009 The influence of the surface fraction of OH groups on fibrinogen (FG) adsorption is investigated in copolymers of ethyl acrylate and hydroxy ethylacrylate. 2-hydroxyethyl acrylate 133-154 fibrinogen beta chain Homo sapiens 54-64 19422014-1 2009 The influence of the surface fraction of OH groups on fibrinogen (FG) adsorption is investigated in copolymers of ethyl acrylate and hydroxy ethylacrylate. 2-hydroxyethyl acrylate 133-154 fibrinogen beta chain Homo sapiens 66-68 19588915-6 2009 The likely cause of enhanced clot turbidity and delay in fibrinolysis was revealed by a crystal structure of the D-dimer from human fibrinogen cocrystallized with GHRPYam, the packing of which showed the direct involvement of the ligand tyrosines in antiparallel betaC-betaC interactions. Tyrosine 237-246 fibrinogen beta chain Homo sapiens 132-142 19406663-0 2009 Cadmium exposure is associated with elevated blood C-reactive protein and fibrinogen in the U. S. population: the third national health and nutrition examination survey (NHANES III, 1988-1994). Cadmium 0-7 fibrinogen beta chain Homo sapiens 74-84 19406663-2 2009 This study explored the hypothesis that cadmium exposure is associated with elevated C-reactive protein (CRP) and fibrinogen, two risk factors for developing cardiovascular disease. Cadmium 40-47 fibrinogen beta chain Homo sapiens 114-124 19406663-3 2009 METHODS: The current study investigated associations between urinary cadmium and the prevalence of elevated blood CRP (> or = 2.2 mg/L) and fibrinogen (> or = 10.35 micromol/L) using data from a sample of 6497 participants aged 40-79 in the Third National Health and Nutrition Examination Survey. Cadmium 69-76 fibrinogen beta chain Homo sapiens 143-153 19406663-5 2009 RESULTS: Both simple and covariate-adjusted models indicated that urinary cadmium was associated with elevated CRP and fibrinogen in a dose-dependent fashion (p(trend)<0.05 for both). Cadmium 74-81 fibrinogen beta chain Homo sapiens 119-129 19406663-6 2009 Adjusted odds ratios for increased CRP and fibrinogen comparing highest with lowest quartiles of urinary cadmium were 1.62 (95% confidence interval [CI], 1.24-2.12) and 2.12 (1.43-3.14), respectively. Cadmium 105-112 fibrinogen beta chain Homo sapiens 43-53 19406663-7 2009 CONCLUSIONS: This analysis shows that cadmium exposure is associated with high prevalence of elevated CRP and fibrinogen. Cadmium 38-45 fibrinogen beta chain Homo sapiens 110-120 19661353-5 2009 CONCLUSION: An increase of serum cholesterol, lipoprotein (a), C-reactive protein and fibrinogen in patients treated with aromatase inhibitors is the result of tamoxifen withdrawal rather than a direct effect of therapy. Tamoxifen 160-169 fibrinogen beta chain Homo sapiens 86-96 19563453-7 2009 In conclusion, in this review the association between an adverse psychosocial working environment and HbA(1c), testosterone and fibrinogen in serum was found to be a robust and potential candidate for a physiological effect of the psychosocial working environment. Testosterone 111-123 fibrinogen beta chain Homo sapiens 128-138 19555253-7 2009 After 12 months, fibrinogen (Fg) decreased compared to baseline with fenofibrate + simvastatin. Fenofibrate 69-80 fibrinogen beta chain Homo sapiens 17-27 19555253-7 2009 After 12 months, fibrinogen (Fg) decreased compared to baseline with fenofibrate + simvastatin. Simvastatin 83-94 fibrinogen beta chain Homo sapiens 17-27 20641311-12 2004 A peptide sequence consisting of Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3. arginyl-glycyl-aspartic acid 33-44 fibrinogen beta chain Homo sapiens 146-156 19429776-7 2009 The ICAM-1(8-22) peptide-induced increases in EGFR phosphotyrosine and phospho-ERK1/2 were prevented by exogenous fibrinogen, by the fibrinogen(117-133) peptide, and by selective inhibitors of phospholipase C (PLC), protein kinase C (PKC)-alpha/beta, and metalloproteases. Phosphotyrosine 51-66 fibrinogen beta chain Homo sapiens 114-124 19429776-7 2009 The ICAM-1(8-22) peptide-induced increases in EGFR phosphotyrosine and phospho-ERK1/2 were prevented by exogenous fibrinogen, by the fibrinogen(117-133) peptide, and by selective inhibitors of phospholipase C (PLC), protein kinase C (PKC)-alpha/beta, and metalloproteases. Phosphotyrosine 51-66 fibrinogen beta chain Homo sapiens 133-143 19039088-6 2009 RESULTS: The hyperactive state of platelets from patients with Crohn"s disease might rely on their enhanced release of sCD40L, since its inhibition by a broad-range inhibitor of MMPs (GM6001) reduced fibrinogen binding induced by platelet stimulation. N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide 184-190 fibrinogen beta chain Homo sapiens 200-210 19422454-5 2009 In agreement with this, in control platelets, monodansyl-cadaverine (MDC), a competitive amino-donor for TGs, inhibited fibrinogen binding induced by TRAP in a dose-dependent manner. monodansylcadaverine 69-72 fibrinogen beta chain Homo sapiens 120-130 19422454-5 2009 In agreement with this, in control platelets, monodansyl-cadaverine (MDC), a competitive amino-donor for TGs, inhibited fibrinogen binding induced by TRAP in a dose-dependent manner. trichlorosucrose 105-108 fibrinogen beta chain Homo sapiens 120-130 21475872-1 2009 Ciprofibrate is a well-known drug used to normalize lipid parameters and fibrinogen in atherosclerosis patients. ciprofibrate 0-12 fibrinogen beta chain Homo sapiens 73-83 19363122-6 2009 Basal [Ca(2+)](cyt) was substantially elevated in PAEC after culture on fibrinogen, fibrin, and thrombin and in PASMC on fibrinogen and fibrin. pasmc 112-117 fibrinogen beta chain Homo sapiens 121-131 19363122-12 2009 In conclusion, chronic exposure to fibrinogen, fibrin, and thrombin caused differential changes in [Ca(2+)](cyt) in PAEC and PASMC. pasmc 125-130 fibrinogen beta chain Homo sapiens 35-45 19411671-9 2009 CONCLUSIONS: In this pilot study, FIBTEM-guided fibrinogen concentrate administration was associated with reduced transfusion requirements and 24 h postoperative bleeding in patients undergoing AV-AA. fibtem 34-40 fibrinogen beta chain Homo sapiens 48-58 19384236-7 2009 Among participants with CIMT> or =0.8 mm, body mass index, blood pressures, total cholesterol, LDL cholesterol, triglycerides, uric acid, C-reactive protein, and fibrinogen were significantly higher, whereas concentrations of vitamin A, vitamin E, lycopene, and beta-carotene were all significantly lower when compared with participants who did not show evidence of carotid atherosclerosis (P<0.001). Vitamin A 229-238 fibrinogen beta chain Homo sapiens 165-175 19384236-7 2009 Among participants with CIMT> or =0.8 mm, body mass index, blood pressures, total cholesterol, LDL cholesterol, triglycerides, uric acid, C-reactive protein, and fibrinogen were significantly higher, whereas concentrations of vitamin A, vitamin E, lycopene, and beta-carotene were all significantly lower when compared with participants who did not show evidence of carotid atherosclerosis (P<0.001). Vitamin E 240-249 fibrinogen beta chain Homo sapiens 165-175 19384236-7 2009 Among participants with CIMT> or =0.8 mm, body mass index, blood pressures, total cholesterol, LDL cholesterol, triglycerides, uric acid, C-reactive protein, and fibrinogen were significantly higher, whereas concentrations of vitamin A, vitamin E, lycopene, and beta-carotene were all significantly lower when compared with participants who did not show evidence of carotid atherosclerosis (P<0.001). Lycopene 251-259 fibrinogen beta chain Homo sapiens 165-175 19320475-0 2009 Effective stabilization of curcumin by association to plasma proteins: human serum albumin and fibrinogen. Curcumin 27-35 fibrinogen beta chain Homo sapiens 95-105 19320475-8 2009 In the presence of both transferrin and IgG, curcumin continues to undergo rapid hydrolysis but this reaction is suppressed by the presence of either HSA or fibrinogen with an impressive yield of approximately 95%. Curcumin 45-53 fibrinogen beta chain Homo sapiens 157-167 19320475-9 2009 Furthermore, the binding constants of curcumin to HSA and fibrinogen are on the order of 10(4) and 10(5) M(-1), respectively. Curcumin 38-46 fibrinogen beta chain Homo sapiens 58-68 19320475-12 2009 Therefore, strong interactions with HSA and fibrinogen inhibit hydrolysis of curcumin and in turn lead to effective suppression of degradation. Curcumin 77-85 fibrinogen beta chain Homo sapiens 44-54 19351158-3 2009 This study examines a series of polyglycerol (PG) dendrons modified by alkanethiols for their interactions with biofouling relevant proteins: fibrinogen (Fib), lysozyme (Lys), albumin (Alb), and pepsin (Pep). polyglycerol 32-44 fibrinogen beta chain Homo sapiens 142-152 20355891-6 2009 Quartz crystal microbalance adsorption studies with human fibrinogen displayed the highest deposition to Ag and the lowest onto the Bactiguard coating. bactiguard 132-142 fibrinogen beta chain Homo sapiens 58-68 19488607-1 2009 OBJECTIVE: To study if metformin, when administered to first-degree relatives of type 2 diabetes mellitus subjects who have metabolic syndrome and normal glucose tolerance, could improve the cardiovascular risk profile and reduce the levels of both C-reactive protein and fibrinogen. Metformin 23-32 fibrinogen beta chain Homo sapiens 272-282 19285494-0 2009 Proteolysis of fibrinogen deposits enables hydrogen peroxide-stimulated polymorphonuclear leukocytes to spread in an acidified environment. Hydrogen Peroxide 43-60 fibrinogen beta chain Homo sapiens 15-25 19285494-2 2009 We previously reported the unusual characteristics of phorbol 12-myristate 13-acetate (PMA)-induced polymorphonuclear leukocyte spreading over immobilized fibrinogen at acidic pH, including extracellular Ca2+ requirement and independence of protein kinase C (PKC) activity. Tetradecanoylphorbol Acetate 54-85 fibrinogen beta chain Homo sapiens 155-165 19285494-2 2009 We previously reported the unusual characteristics of phorbol 12-myristate 13-acetate (PMA)-induced polymorphonuclear leukocyte spreading over immobilized fibrinogen at acidic pH, including extracellular Ca2+ requirement and independence of protein kinase C (PKC) activity. Tetradecanoylphorbol Acetate 87-90 fibrinogen beta chain Homo sapiens 155-165 19285494-3 2009 In the present study, we found that PMA-induced spreading was strongly inhibited at pH 6.0 by the serine protease inhibitor phenylmethanesulfonylfluoride at pH 6.0 but was only mildly inhibited at pH 7.2 and not inhibited at pH 8.0; furthermore, PMA-stimulated polymorphonuclear leukocytes markedly digested immobilized fibrinogen only at pH 6.0. Tetradecanoylphorbol Acetate 36-39 fibrinogen beta chain Homo sapiens 320-330 19285494-3 2009 In the present study, we found that PMA-induced spreading was strongly inhibited at pH 6.0 by the serine protease inhibitor phenylmethanesulfonylfluoride at pH 6.0 but was only mildly inhibited at pH 7.2 and not inhibited at pH 8.0; furthermore, PMA-stimulated polymorphonuclear leukocytes markedly digested immobilized fibrinogen only at pH 6.0. phenylmethanesulfonylfluoride 124-153 fibrinogen beta chain Homo sapiens 320-330 19285494-4 2009 In experiments without stimulation by PMA, we found that at pH 6.0 polymorphonuclear leukocytes were able to spread over fibrinogen surfaces pre-digested by neutrophil serine proteases; this process required extracellular Ca2+ and stimulation by hydrogen peroxide (H2O2). Hydrogen Peroxide 246-263 fibrinogen beta chain Homo sapiens 121-131 19285494-4 2009 In experiments without stimulation by PMA, we found that at pH 6.0 polymorphonuclear leukocytes were able to spread over fibrinogen surfaces pre-digested by neutrophil serine proteases; this process required extracellular Ca2+ and stimulation by hydrogen peroxide (H2O2). Hydrogen Peroxide 265-269 fibrinogen beta chain Homo sapiens 121-131 19285494-5 2009 Pharmacological studies demonstrated the involvement of Src family protein tyrosine kinases, but not PKC, in H2O2-induced spreading over pre-digested fibrinogen surfaces; this was also the case for PMA-induced spreading at pH 6.0 but not at pH 7.2 or 8.0. Hydrogen Peroxide 109-113 fibrinogen beta chain Homo sapiens 150-160 19285494-5 2009 Pharmacological studies demonstrated the involvement of Src family protein tyrosine kinases, but not PKC, in H2O2-induced spreading over pre-digested fibrinogen surfaces; this was also the case for PMA-induced spreading at pH 6.0 but not at pH 7.2 or 8.0. Tetradecanoylphorbol Acetate 198-201 fibrinogen beta chain Homo sapiens 150-160 19390750-1 2009 OBJECTIVE: To elucidate the association between vitamin D status, C-reactive protein (CRP) and fibrinogen. Vitamin D 48-57 fibrinogen beta chain Homo sapiens 95-105 19320829-0 2009 Fibrinogen substitution improves whole blood clot firmness after dilution with hydroxyethyl starch in bleeding patients undergoing radical cystectomy: a randomized, placebo-controlled clinical trial. Hydroxyethyl starch 79-98 fibrinogen beta chain Homo sapiens 0-10 19320829-3 2009 OBJECTIVES: The aims of the present prospective, randomized, placebo-controlled trial were to investigate the hemostatic effect of a fibrinogen concentrate after coagulopathy induced by hydroxyethyl starch in patients experiencing sudden excessive bleeding during elective cystectomy. Hydroxyethyl starch 186-205 fibrinogen beta chain Homo sapiens 133-143 19090492-5 2009 This study provides evidence that the rapid and tenacious binding of albumin molecules to DLC materials tends to passivate the surfaces and to inhibit Fng adsorption, thus imparting thromboresistance to the carbon coatings by rendering the surfaces less adhesive and activating for platelets. Carbon 207-213 fibrinogen beta chain Homo sapiens 151-154 19422454-5 2009 In agreement with this, in control platelets, monodansyl-cadaverine (MDC), a competitive amino-donor for TGs, inhibited fibrinogen binding induced by TRAP in a dose-dependent manner. monodansylcadaverine 46-67 fibrinogen beta chain Homo sapiens 120-130 19572064-6 2009 SDS-PAGE and immunoblotting showed doublet bands in the positions of the high-molecular weight (HMW)- and low-molecular-weight (LMW)-fibrinogen, a single LMW" fibrinogen band, plus additional bands with higher molecular weight than HMW-fibrinogen, which were also reactive with anti-human serum albumin (HSA) antiserum. Sodium Dodecyl Sulfate 0-3 fibrinogen beta chain Homo sapiens 159-169 19572064-6 2009 SDS-PAGE and immunoblotting showed doublet bands in the positions of the high-molecular weight (HMW)- and low-molecular-weight (LMW)-fibrinogen, a single LMW" fibrinogen band, plus additional bands with higher molecular weight than HMW-fibrinogen, which were also reactive with anti-human serum albumin (HSA) antiserum. Sodium Dodecyl Sulfate 0-3 fibrinogen beta chain Homo sapiens 159-169 18790543-0 2009 Sulfotanshinone Sodium Injection could decrease fibrinogen level and improve clinical outcomes in patients with unstable angina pectoris. tanshinone II A sodium sulfonate 0-22 fibrinogen beta chain Homo sapiens 48-58 19458875-4 2009 RPE-1 cells seeded on fibronectin/fibrinogen-Alexa 488 patterns were constrained for days on the deep UV exposed regions. Alexa-488 45-54 fibrinogen beta chain Homo sapiens 34-44 19384236-7 2009 Among participants with CIMT> or =0.8 mm, body mass index, blood pressures, total cholesterol, LDL cholesterol, triglycerides, uric acid, C-reactive protein, and fibrinogen were significantly higher, whereas concentrations of vitamin A, vitamin E, lycopene, and beta-carotene were all significantly lower when compared with participants who did not show evidence of carotid atherosclerosis (P<0.001). beta Carotene 265-278 fibrinogen beta chain Homo sapiens 165-175 19548907-11 2009 A key mechanism of aggregate dispersal was antagonist-induced displacement of platelet-bound fibrinogen, which was greater with eptifibatide, a competitive inhibitor of fibrinogen binding, than with the noncompetitive inhibitor, abciximab. Eptifibatide 128-140 fibrinogen beta chain Homo sapiens 93-103 19548907-11 2009 A key mechanism of aggregate dispersal was antagonist-induced displacement of platelet-bound fibrinogen, which was greater with eptifibatide, a competitive inhibitor of fibrinogen binding, than with the noncompetitive inhibitor, abciximab. Eptifibatide 128-140 fibrinogen beta chain Homo sapiens 169-179 19352213-12 2009 CONCLUSION: There was evidence of pharmacogenetic effects of FGB-455 on stroke, ESRD, and mortality, suggesting that relative to those homozygous for the common allele, variant allele carriers of the FGB gene at position -455 have a better outcome if randomized to lisinopril than chlorthalidone (for mortality and ESRD) or amlodipine (for mortality and stroke). Lisinopril 265-275 fibrinogen beta chain Homo sapiens 200-203 19352213-12 2009 CONCLUSION: There was evidence of pharmacogenetic effects of FGB-455 on stroke, ESRD, and mortality, suggesting that relative to those homozygous for the common allele, variant allele carriers of the FGB gene at position -455 have a better outcome if randomized to lisinopril than chlorthalidone (for mortality and ESRD) or amlodipine (for mortality and stroke). Chlorthalidone 281-295 fibrinogen beta chain Homo sapiens 200-203 19352213-12 2009 CONCLUSION: There was evidence of pharmacogenetic effects of FGB-455 on stroke, ESRD, and mortality, suggesting that relative to those homozygous for the common allele, variant allele carriers of the FGB gene at position -455 have a better outcome if randomized to lisinopril than chlorthalidone (for mortality and ESRD) or amlodipine (for mortality and stroke). Amlodipine 324-334 fibrinogen beta chain Homo sapiens 200-203 19366199-0 2009 Fibrinogen adsorption and conformational change on model polymers: novel aspects of mutual molecular rearrangement. Polymers 57-65 fibrinogen beta chain Homo sapiens 0-10 19366199-1 2009 By combining quartz crystal microbalance with dissipation monitoring (QCM-D) and surface plasmon resonance (SPR), the organic mass, water content, and corresponding protein film structure of fibrinogen adsorbed to acrylic polymeric substrates with varying polymer chain flexibility was investigated. Polymers 222-229 fibrinogen beta chain Homo sapiens 191-201 19366199-3 2009 For fibrinogen, the QCM-D model resulted in decreased adsorbed mass with increased polymer chain flexibility. Polymers 83-90 fibrinogen beta chain Homo sapiens 4-14 19366199-6 2009 Fibrinogen maintained a more native conformation on the flexible polymer, probably due to polymer chain rearrangement rather than protein conformational change. Polymers 65-72 fibrinogen beta chain Homo sapiens 0-10 19366199-6 2009 Fibrinogen maintained a more native conformation on the flexible polymer, probably due to polymer chain rearrangement rather than protein conformational change. Polymers 90-97 fibrinogen beta chain Homo sapiens 0-10 19388638-3 2009 Surface plasmon resonance spectroscopy was used to measure the adsorption of fibrinogen, lysozyme, albumin, and pepsin to the resulting mixed PG amide/carboxylate-terminated SAMs. Amides 145-150 fibrinogen beta chain Homo sapiens 77-87 19388638-3 2009 Surface plasmon resonance spectroscopy was used to measure the adsorption of fibrinogen, lysozyme, albumin, and pepsin to the resulting mixed PG amide/carboxylate-terminated SAMs. carboxylate 151-162 fibrinogen beta chain Homo sapiens 77-87 19388638-3 2009 Surface plasmon resonance spectroscopy was used to measure the adsorption of fibrinogen, lysozyme, albumin, and pepsin to the resulting mixed PG amide/carboxylate-terminated SAMs. SAMS Peptide 174-178 fibrinogen beta chain Homo sapiens 77-87 19214165-8 2009 In stepwise multiple linear regression, hypertension (P = 0.013) and fibrinogen levels (P = 0.027) were significant independent predictors of sF11R level. sf11r 142-147 fibrinogen beta chain Homo sapiens 69-79 19396049-3 2009 The aim was to determine the effect of fenofibrate treatment on Fb level, fibrinolysis, and platelet function in patients with MS with regard to smoking status and type 2 diabetes. Fenofibrate 39-50 fibrinogen beta chain Homo sapiens 64-66 19396049-7 2009 RESULTS: Fenofibrate treatment resulted in normalization of abnormal lipid profiles and a reduction in Fb level. Fenofibrate 9-20 fibrinogen beta chain Homo sapiens 103-105 19396049-11 2009 CONCLUSIONS: Fenofibrate partially corrected procoagulant state in patients with MS, which was manifested by a significant reduction in Fb level in all patients and inhibition of platelet function exclusively in nonsmokers. Fenofibrate 13-24 fibrinogen beta chain Homo sapiens 136-138 19555809-9 2009 In addition, we found simvastatin-induced increases in aspartate transaminase and fibrinogen to be attenuated by L-arginine as compared to placebo. Arginine 113-123 fibrinogen beta chain Homo sapiens 82-92 19275182-1 2009 Atomic force microscopy (AFM) was used to analyze the interactions between fibrinogen and model surfaces having different levels of water wettability. Water 132-137 fibrinogen beta chain Homo sapiens 75-85 19075185-1 2009 Fibrinogen residue Bbeta432Asp is part of hole "b" that interacts with knob "B," whose sequence starts with Gly-His-Arg-Pro-amide (GHRP). gly-his-arg-pro-amide 108-129 fibrinogen beta chain Homo sapiens 0-10 19075185-1 2009 Fibrinogen residue Bbeta432Asp is part of hole "b" that interacts with knob "B," whose sequence starts with Gly-His-Arg-Pro-amide (GHRP). ghrp 131-135 fibrinogen beta chain Homo sapiens 0-10 19147224-3 2009 Here we show that unmodified native fibrinogen can also be photochemically crosslinked into an elastic hydrogel biomaterial through the rapid formation of intermolecular dityrosine. dityrosine 170-180 fibrinogen beta chain Homo sapiens 36-46 19417476-0 2009 The influence of glancing angle deposited nano-rough platinum surfaces on the adsorption of fibrinogen and the proliferation of primary human fibroblasts. Platinum 53-61 fibrinogen beta chain Homo sapiens 92-102 19341914-5 2009 Another recent novel approach is the assembling of hemoglobin and fibrinogen into a soluble nanodimension polyhemoglobin-fibrinogen complex that acts as an oxygen carrier with platelet-like activity. Oxygen 156-162 fibrinogen beta chain Homo sapiens 66-76 19341914-5 2009 Another recent novel approach is the assembling of hemoglobin and fibrinogen into a soluble nanodimension polyhemoglobin-fibrinogen complex that acts as an oxygen carrier with platelet-like activity. Oxygen 156-162 fibrinogen beta chain Homo sapiens 121-131 19268506-4 2009 RESULTS: Fibrinogen was reduced in both groups but more markedly in the DYDR group. dydr 72-76 fibrinogen beta chain Homo sapiens 9-19 19268506-14 2009 The fibrinogen level and Lp(a) were more decreased during dydrogesterone treatment. Dydrogesterone 58-72 fibrinogen beta chain Homo sapiens 4-14 19327165-5 2009 RESULTS: Upon normalization of serum testosterone there was an improvement of hyperglycemia, a decrease of leukocytes and of fibrinogen levels, an increase of antithrombin III activity and of tissue oxygen pressure. Testosterone 37-49 fibrinogen beta chain Homo sapiens 125-135 18314896-4 2009 The graft copolymers PEI-PEG and PLL-PEG were adsorbed at the SAMs and tested for resistance towards human serum albumin and fibrinogen. pll-peg 33-40 fibrinogen beta chain Homo sapiens 125-135 19718794-7 2009 The ability of the polymer coating to prevent the adsorption of human serum albumin (HSA) and fibrinogen (FBG) was evaluated. Polymers 19-26 fibrinogen beta chain Homo sapiens 70-104 19157885-0 2009 Interaction study of bioactive molecules with fibrinogen and human platelets determined by 1H NMR relaxation experiments. Hydrogen 91-93 fibrinogen beta chain Homo sapiens 46-56 19157885-3 2009 In this paper, we applied this methodology to investigate the affinity of epinephrine and isoproterenol towards two different systems: fibrinogen and platelets. Epinephrine 74-85 fibrinogen beta chain Homo sapiens 135-145 19157885-3 2009 In this paper, we applied this methodology to investigate the affinity of epinephrine and isoproterenol towards two different systems: fibrinogen and platelets. Isoproterenol 90-103 fibrinogen beta chain Homo sapiens 135-145 19058845-7 2009 When held at constant strain, electrospun fibrinogen fibers showed a fast and slow stress relaxation time of 3 and 55 s. Our fibers were spun from the typically used 90% 1,1,1,3,3,3-hexafluoro-2-propanol (90-HFP) electrospinning solution and re-suspended in aqueous buffer. hexafluoroisopropanol 170-203 fibrinogen beta chain Homo sapiens 42-52 19437703-5 2009 Compared with unmodified silicon surfaces, a Si-PVP60 surface with a PVP thickness of 15.06 nm reduced the level of adsorption of fibrinogen, human serum albumin (HSA), and lysozyme by 75, 93, and 81%, respectively. Silicon 25-32 fibrinogen beta chain Homo sapiens 130-140 19437712-3 2009 Human fibrinogen and albumin were adsorbed onto alkanethiol self-assembled monolayers (SAMs) on gold with CH3, OCH2-CF3, NH2, COOH, and OH terminal groups from both dilute (0.1 mg/mL) and moderately concentrated (1.0 mg/mL) solutions. SAMS Peptide 87-91 fibrinogen beta chain Homo sapiens 6-16 19027155-3 2009 The disruption of the phospholipid monolayer depends on the type of protein (albumin, neutravidin, and fibrinogen) adsorbing onto nanoparticles. Phospholipids 22-34 fibrinogen beta chain Homo sapiens 103-113 19135623-9 2009 Valproic acid can increase lipoprotein(a) and decrease fibrinogen, which may increase the risk of stroke or other thrombotic events. Valproic Acid 0-13 fibrinogen beta chain Homo sapiens 55-65 19513421-2 2009 The effects of oxidized fibrinogen preparations on the clot formation by citrate-treated donor plasma were evaluated by the thrombin time test. Citric Acid 73-80 fibrinogen beta chain Homo sapiens 24-34 18853456-0 2009 A deep intronic mutation in FGB creates a consensus exonic splicing enhancer motif that results in afibrinogenemia caused by aberrant mRNA splicing, which can be corrected in vitro with antisense oligonucleotide treatment. Oligonucleotides 196-211 fibrinogen beta chain Homo sapiens 28-31 18840708-6 2009 Fibrinogen binding to alphaIIbbeta3 caused an increase in integrin-associated cPLA(2)alpha activity in normal platelets, but not in cPLA(2)alpha-deficient mouse platelets or in human platelets treated with pyrrophenone, a cPLA(2)alpha inhibitor. pyrrophenone 206-218 fibrinogen beta chain Homo sapiens 0-10 19232047-5 2009 Using infrared spectroscopy, it has been shown that free radical oxidation of amino acid residues of fibrinogen polypeptide chains catalyzed by ozone results in formation of carbonyl, hydroxyl, and ether groups. Hydroxyl Radical 184-192 fibrinogen beta chain Homo sapiens 101-111 19232047-5 2009 Using infrared spectroscopy, it has been shown that free radical oxidation of amino acid residues of fibrinogen polypeptide chains catalyzed by ozone results in formation of carbonyl, hydroxyl, and ether groups. Ether 198-203 fibrinogen beta chain Homo sapiens 101-111 19004623-6 2009 On the contrary, the thick and viscous fibrin layer was altered gradually to more fibrinogen-like layer as the heparin concentration increases at low concentrations of AT, demonstrating the powerful anticoagulant effect by heparin/AT complex. Heparin 111-118 fibrinogen beta chain Homo sapiens 82-92 19004623-6 2009 On the contrary, the thick and viscous fibrin layer was altered gradually to more fibrinogen-like layer as the heparin concentration increases at low concentrations of AT, demonstrating the powerful anticoagulant effect by heparin/AT complex. Heparin 223-230 fibrinogen beta chain Homo sapiens 82-92 19240823-9 2009 Then the specific anti-tumor therapy (ciproteron acetate) was initiated, and two weeks later, fibrinogen concentration and TT returned to normal values. ciproteron acetate 38-56 fibrinogen beta chain Homo sapiens 94-104 19723441-3 2009 In this study, cell response to the architecture of protein ligands, bovine type-I collagen (CG) and human fibrinogen (Fg), immobilised using different methods on poly(2-hydroxyethyl methacrylate) (pHEMA) macroporous hydrogels (MHs) was analysed. Polyhydroxyethyl Methacrylate 163-196 fibrinogen beta chain Homo sapiens 107-117 19129740-2 2009 To assess whether this finding related to modifications of fibrinogen clotting property by ASA, purified fibrinogen was incubated with ASA and/or salicylic acid (SA). Aspirin 91-94 fibrinogen beta chain Homo sapiens 59-69 19129740-2 2009 To assess whether this finding related to modifications of fibrinogen clotting property by ASA, purified fibrinogen was incubated with ASA and/or salicylic acid (SA). Aspirin 135-138 fibrinogen beta chain Homo sapiens 105-115 19129740-2 2009 To assess whether this finding related to modifications of fibrinogen clotting property by ASA, purified fibrinogen was incubated with ASA and/or salicylic acid (SA). Salicylic Acid 146-160 fibrinogen beta chain Homo sapiens 105-115 19129740-2 2009 To assess whether this finding related to modifications of fibrinogen clotting property by ASA, purified fibrinogen was incubated with ASA and/or salicylic acid (SA). Salicylic Acid 92-94 fibrinogen beta chain Homo sapiens 59-69 18567052-0 2008 Interactions of KLVFF-PEG peptide conjugate with fibrinogen in neutral aqueous solutions. Polyethylene Glycols 22-25 fibrinogen beta chain Homo sapiens 49-59 19529851-4 2009 An increase in the width of aggregation curves was most pronounced in the system of 10(-4) M Fe(2+) and 10(-4) M H(2)O(2) with oxidized fibrinogen. ammonium ferrous sulfate 93-99 fibrinogen beta chain Homo sapiens 136-146 19529851-4 2009 An increase in the width of aggregation curves was most pronounced in the system of 10(-4) M Fe(2+) and 10(-4) M H(2)O(2) with oxidized fibrinogen. Water 113-119 fibrinogen beta chain Homo sapiens 136-146 18567052-1 2008 In this work we report on the interaction of KLVFF-PEG with fibrinogen (Fbg) in neutral aqueous solutions at 20 degrees C, for particular ratios of KLVFF-PEG to Fbg concentration, Delta = c(KLVFF-PEG)/c(Fbg). klvff-peg 45-54 fibrinogen beta chain Homo sapiens 60-70 18567052-1 2008 In this work we report on the interaction of KLVFF-PEG with fibrinogen (Fbg) in neutral aqueous solutions at 20 degrees C, for particular ratios of KLVFF-PEG to Fbg concentration, Delta = c(KLVFF-PEG)/c(Fbg). klvff-peg 45-54 fibrinogen beta chain Homo sapiens 72-75 18567052-1 2008 In this work we report on the interaction of KLVFF-PEG with fibrinogen (Fbg) in neutral aqueous solutions at 20 degrees C, for particular ratios of KLVFF-PEG to Fbg concentration, Delta = c(KLVFF-PEG)/c(Fbg). klvff-peg 45-54 fibrinogen beta chain Homo sapiens 161-164 18567052-1 2008 In this work we report on the interaction of KLVFF-PEG with fibrinogen (Fbg) in neutral aqueous solutions at 20 degrees C, for particular ratios of KLVFF-PEG to Fbg concentration, Delta = c(KLVFF-PEG)/c(Fbg). klvff-peg 45-54 fibrinogen beta chain Homo sapiens 161-164 18567052-1 2008 In this work we report on the interaction of KLVFF-PEG with fibrinogen (Fbg) in neutral aqueous solutions at 20 degrees C, for particular ratios of KLVFF-PEG to Fbg concentration, Delta = c(KLVFF-PEG)/c(Fbg). klvff-peg 148-157 fibrinogen beta chain Homo sapiens 60-70 18567052-1 2008 In this work we report on the interaction of KLVFF-PEG with fibrinogen (Fbg) in neutral aqueous solutions at 20 degrees C, for particular ratios of KLVFF-PEG to Fbg concentration, Delta = c(KLVFF-PEG)/c(Fbg). klvff-peg 148-157 fibrinogen beta chain Homo sapiens 72-75 18567052-1 2008 In this work we report on the interaction of KLVFF-PEG with fibrinogen (Fbg) in neutral aqueous solutions at 20 degrees C, for particular ratios of KLVFF-PEG to Fbg concentration, Delta = c(KLVFF-PEG)/c(Fbg). klvff-peg 148-157 fibrinogen beta chain Homo sapiens 60-70 18567052-1 2008 In this work we report on the interaction of KLVFF-PEG with fibrinogen (Fbg) in neutral aqueous solutions at 20 degrees C, for particular ratios of KLVFF-PEG to Fbg concentration, Delta = c(KLVFF-PEG)/c(Fbg). klvff-peg 148-157 fibrinogen beta chain Homo sapiens 72-75 18567052-2 2008 Our results show the formation of Fbg/KLVFF-PEG complexes for Delta > 0, such that there is not an extended network of complexes throughout the solution. Polyethylene Glycols 44-47 fibrinogen beta chain Homo sapiens 34-37 18567052-4 2008 There is a dramatic change in the tertiary structure of the Fbg upon KLVFF-PEG binding, although the KLVFF-PEG binds to the Fbg without affecting the secondary structure elements of the glycoprotein. klvff-peg 69-78 fibrinogen beta chain Homo sapiens 60-63 18567052-4 2008 There is a dramatic change in the tertiary structure of the Fbg upon KLVFF-PEG binding, although the KLVFF-PEG binds to the Fbg without affecting the secondary structure elements of the glycoprotein. klvff-peg 101-110 fibrinogen beta chain Homo sapiens 124-127 20641919-12 2004 A peptide sequence consisting of Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3. arginyl-glycyl-aspartic acid 33-44 fibrinogen beta chain Homo sapiens 146-156 18818200-0 2008 Fibrinogen beta-chain tyrosine nitration is a prothrombotic risk factor. Tyrosine 22-30 fibrinogen beta chain Homo sapiens 0-10 18818200-2 2008 We hypothesized that a potential mechanism for an increased prothrombotic state is the post-translational modification of fibrinogen by tyrosine nitration. Tyrosine 136-144 fibrinogen beta chain Homo sapiens 122-132 18818200-3 2008 Mass spectrometry identified tyrosine residues 292 and 422 at the carboxyl terminus of the beta-chain as the principal sites of fibrinogen nitration in vivo. Tyrosine 29-37 fibrinogen beta chain Homo sapiens 128-138 18818200-6 2008 The rate of fibrin clot formation and clot architecture was restored upon depletion of the tyrosine-nitrated fibrinogen molecules. Tyrosine 91-99 fibrinogen beta chain Homo sapiens 109-119 18818200-7 2008 An enhanced response to the knob "B" mimetic peptides Gly-His-Arg-Pro(am) and Ala-His-Arg-Pro(am) suggests that incorporation of nitrated fibrinogen molecules accelerates fibrin lateral aggregation. glycylhistidine 54-61 fibrinogen beta chain Homo sapiens 138-148 18818200-7 2008 An enhanced response to the knob "B" mimetic peptides Gly-His-Arg-Pro(am) and Ala-His-Arg-Pro(am) suggests that incorporation of nitrated fibrinogen molecules accelerates fibrin lateral aggregation. arginylproline 62-69 fibrinogen beta chain Homo sapiens 138-148 18818200-7 2008 An enhanced response to the knob "B" mimetic peptides Gly-His-Arg-Pro(am) and Ala-His-Arg-Pro(am) suggests that incorporation of nitrated fibrinogen molecules accelerates fibrin lateral aggregation. alanylhistidine 78-85 fibrinogen beta chain Homo sapiens 138-148 18818200-7 2008 An enhanced response to the knob "B" mimetic peptides Gly-His-Arg-Pro(am) and Ala-His-Arg-Pro(am) suggests that incorporation of nitrated fibrinogen molecules accelerates fibrin lateral aggregation. Arginine 62-65 fibrinogen beta chain Homo sapiens 138-148 18818200-7 2008 An enhanced response to the knob "B" mimetic peptides Gly-His-Arg-Pro(am) and Ala-His-Arg-Pro(am) suggests that incorporation of nitrated fibrinogen molecules accelerates fibrin lateral aggregation. Proline 66-69 fibrinogen beta chain Homo sapiens 138-148 19055578-3 2008 In human medicine, fibrinogen can be precipitated from plasma using ethanol. Ethanol 68-75 fibrinogen beta chain Homo sapiens 19-29 18812188-1 2008 This paper concerns the interaction between hyaluronan and fibrinogen as model for protein-polysaccharide interaction. Polysaccharides 91-105 fibrinogen beta chain Homo sapiens 59-69 19261978-4 2008 Protein targets for the modification by Hcy-thiolactone include fibrinogen, low-density lipoprotein, high-density lipoprotein, albumin, hemoglobin, and ferritin. homocysteine thiolactone 40-55 fibrinogen beta chain Homo sapiens 64-74 19100419-11 2008 Compared with patients in the ASA-sensitive group, patients in the ASA-resistant group showed significantly higher total cholesterol, low-density lipoprotein cholesterol, triglyceride, C-reactive protein, and fibrinogen levels and lower GFRs (44 +/- 21 mL/min vs 63 +/- 26 mL/min, P = .03). Aspirin 67-70 fibrinogen beta chain Homo sapiens 209-219 19055578-4 2008 OBJECTIVES: The purpose of this study was to assess ethanol precipitation as a method for removing fibrinogen from canine plasma so as to facilitate the interpretation of electorphoresis results. Ethanol 52-59 fibrinogen beta chain Homo sapiens 99-109 19055578-8 2008 To verify the efficiency of ethanol treatment, fibrinogen was added to 5 canine serum samples at final concentrations of 2.5, 5.0, and 10.0 g/L, and electrophoresis was performed before and after ethanol treatment. Ethanol 28-35 fibrinogen beta chain Homo sapiens 47-57 19055578-9 2008 RESULTS: Visual analysis of electrophoretograms from ethanol-treated samples confirmed the disappearance of the fibrinogen peak from the beta(2)-globulin region. Ethanol 53-60 fibrinogen beta chain Homo sapiens 112-122 19055578-12 2008 CONCLUSIONS: Ethanol treatment successfully removed fibrinogen from canine plasma and normalized electrophoretic profiles, but probably also precipitated proteins other than fibrinogen. Ethanol 13-20 fibrinogen beta chain Homo sapiens 52-62 18981961-3 2008 SUMMARY OF BACKGROUND DATA: Previously, a preliminary prospective; prospective randomized double-blind; same-day anterior and posterior spinal fusion; and fibrinogen studies have demonstrated Amicar to be effective in decreasing total perioperative blood loss and transfusion requirements in surgery for idiopathic scoliosis. Aminocaproic Acid 192-198 fibrinogen beta chain Homo sapiens 155-165 18676163-6 2008 Both mutations were demonstrated to cause a severe impairment of intracellular fibrinogen processing, either by affecting half-molecule dimerization (alphaCys45Phe) or by hampering hexamer secretion (gammaAsn345Ser). gammaasn345ser 200-214 fibrinogen beta chain Homo sapiens 79-89 18937403-0 2008 Novel biopolymeric template for the nucleation and growth of hydroxyapatite crystals based on self-assembled fibrinogen fibrils. Durapatite 61-75 fibrinogen beta chain Homo sapiens 109-119 18937403-1 2008 We prepared amyloid-like fibrinogen (Fg) fibrils at pH 2.0 in the absence of thrombin; furthermore, we prepared uniform 2-D Fg fibril networks on a hydrophilic mica matrix. mica 160-164 fibrinogen beta chain Homo sapiens 124-126 19198072-3 2008 IR-spectroscopy data indicate that the degree of fibrinogen oxidation positively correlates with the amount of epsilon/gamma(-glu)lys isopeptide covalent bonds whose formation is catalyzed by the factor XIIIa. Glutamic Acid 126-129 fibrinogen beta chain Homo sapiens 49-59 18989530-5 2008 We examined the effects of GSH-GSSG on the adhesion of CHO cells expressing two HPA variants of human alpha(IIb)beta(3) to the immobilized fibrinogen and von Willebrand factor (VWF) under flow conditions. Glutathione 27-30 fibrinogen beta chain Homo sapiens 139-149 18989530-6 2008 GSH-GSSG dose-dependently reduced the number of adherent cells to fibrinogen and VWF under 2.5 dyn/cm(2) of shear stress, a physical force calculated to be 110 dyne on platelets. Glutathione 0-3 fibrinogen beta chain Homo sapiens 66-76 18989530-6 2008 GSH-GSSG dose-dependently reduced the number of adherent cells to fibrinogen and VWF under 2.5 dyn/cm(2) of shear stress, a physical force calculated to be 110 dyne on platelets. Glutathione Disulfide 4-8 fibrinogen beta chain Homo sapiens 66-76 18646252-5 2008 The YMESRADR octapeptide inhibits ADP-stimulated human platelets aggregation and binds to immobilized fibrinogen. Adenosine Diphosphate 34-37 fibrinogen beta chain Homo sapiens 102-112 18848137-0 2008 Elevated plasma fibrinogen and diabetes mellitus are associated with lower inhibition of platelet reactivity with clopidogrel. Clopidogrel 114-125 fibrinogen beta chain Homo sapiens 16-26 18022259-3 2008 We investigated the rate of hepatic fibrinogen synthesis by measuring the rate of incorporation of deuterated phenylalanine into circulating plasma fibrinogen. deuterated phenylalanine 99-123 fibrinogen beta chain Homo sapiens 36-46 18022259-3 2008 We investigated the rate of hepatic fibrinogen synthesis by measuring the rate of incorporation of deuterated phenylalanine into circulating plasma fibrinogen. deuterated phenylalanine 99-123 fibrinogen beta chain Homo sapiens 148-158 18022259-5 2008 Blood drawn at intervals allowed measurement of the rate of [(2)H(5)]-phenylalanine enrichment in fibrinogen by gas chromatography-mass spectrometry. [(2)h(5)] 60-69 fibrinogen beta chain Homo sapiens 98-108 18022259-5 2008 Blood drawn at intervals allowed measurement of the rate of [(2)H(5)]-phenylalanine enrichment in fibrinogen by gas chromatography-mass spectrometry. Phenylalanine 70-83 fibrinogen beta chain Homo sapiens 98-108 18258237-5 2008 By multivariate analysis we searched, among all baseline parameters, for independent variables associated with the events and we found a predictive role for elevated fibrinogen concentrations (OR 6.3, 95% CI 2.0-19.6, p=.0016), family history of coronary artery disease (OR 4.5, 95% CI 1.7-12.8, p=.0045) and lower HDL-cholesterol levels (OR 1.4, 95% CI 1.1-1.9, p=.0278). Cholesterol 319-330 fibrinogen beta chain Homo sapiens 166-176 17622488-11 2008 The relationship between the level of hypoxemia and microalbuminuria, fibrinogen and vWF was found to be significant (r = -0.360, P = 0.005 between oxygen saturation and microalbuminuria, r = -0.359, P = 0.005 between the level of PaO(2) and fibrinogen, and r = -0.336, P = 0.009 between PaO(2) and vWF). Oxygen 148-154 fibrinogen beta chain Homo sapiens 70-80 17629773-0 2008 Higher morning serum cortisol level predicts increased fibrinogen but not shortened APTT. Hydrocortisone 21-29 fibrinogen beta chain Homo sapiens 55-65 17629773-7 2008 In multivariable linear regression analysis, the concentration of fibrinogen, but not the value of the APTT, was significantly associated with morning serum cortisol. Hydrocortisone 157-165 fibrinogen beta chain Homo sapiens 66-76 17629773-8 2008 CONCLUSIONS: The results of this retrospective investigation confirm that baseline cortisol levels might predict higher fibrinogen in the general population. Hydrocortisone 83-91 fibrinogen beta chain Homo sapiens 120-130 19014658-11 2008 In DTC subjects, plasma fibrinogen concentrations correlated positively with insulin resistance, cholesterol and LDL-cholesterol, and negatively with TSH levels. Cholesterol 97-108 fibrinogen beta chain Homo sapiens 24-34 19014658-11 2008 In DTC subjects, plasma fibrinogen concentrations correlated positively with insulin resistance, cholesterol and LDL-cholesterol, and negatively with TSH levels. Cholesterol 117-128 fibrinogen beta chain Homo sapiens 24-34 19014658-11 2008 In DTC subjects, plasma fibrinogen concentrations correlated positively with insulin resistance, cholesterol and LDL-cholesterol, and negatively with TSH levels. Thyrotropin 150-153 fibrinogen beta chain Homo sapiens 24-34 18989530-10 2008 The results suggest that GSH may have distinct effects on agonist-induced alpha(IIb)beta(3) activation and on the alpha(IIb)beta(3)-fibrinogen or alpha(IIb)beta(3)-VWF bonds when exposed to fluid shear stress. Glutathione 25-28 fibrinogen beta chain Homo sapiens 132-142 20641690-17 2004 A peptide sequence consisting of Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3. arginyl-glycyl-aspartic acid 33-44 fibrinogen beta chain Homo sapiens 146-156 18848137-9 2008 CONCLUSIONS: Elevated plasma fibrinogen (> or =375 mg/dl) in the presence of diabetes mellitus and increased BMI (> or =25 kg/m(2)) are associated with lower PI with clopidogrel in patients with CVD. Clopidogrel 172-183 fibrinogen beta chain Homo sapiens 29-39 18813885-7 2008 RESULTS: Patients discharged with triple therapy including OAC seemed to be at higher risk: patients in group 3 had decreased left ventricular ejection fraction and increased inflammatory state as measured by plasma fibrinogen and C-reactive protein. SDZ 33-243 59-62 fibrinogen beta chain Homo sapiens 216-226 18794767-3 2008 SUMMARY OF BACKGROUND DATA: Preliminary prospective, prospective randomized double-blind, and fibrinogen studies have demonstrated Amicar to be effective in decreasing perioperative blood loss in patients with idiopathic scoliosis undergoing PSF with SSI. Aminocaproic Acid 131-137 fibrinogen beta chain Homo sapiens 94-104 18726029-1 2008 Fibrinogen (Fg) nanofibrils were prepared by the ethanol-induced self-assembly of Fg molecules, which can be used as fibrous scaffolds to organize gold nanoparticles (NPs). Ethanol 49-56 fibrinogen beta chain Homo sapiens 0-10 18780206-0 2008 Dosing time-dependent effect of raloxifene on plasma fibrinogen concentration in ovariectomized rats. Raloxifene Hydrochloride 32-42 fibrinogen beta chain Homo sapiens 53-63 20408704-4 2008 To identify and evaluate new materials for neural communication electrodes, three charged biomolecules, fibrinogen, hyaluronic acid (HA), and heparin are used as counterions in the electrochemical polymerization of poly(3,4-ethylenedioxythiophene) (PEDOT). poly(3,4-ethylene dioxythiophene) 215-247 fibrinogen beta chain Homo sapiens 104-114 18780206-9 2008 Because fibrinogen concentration is reported to be a marker of cardiovascular events, consideration of dosing time of raloxifene may be important to obtain a better cardioprotective effect of this medication when it is prescribed to postmenopausal women with osteoporosis. Raloxifene Hydrochloride 118-128 fibrinogen beta chain Homo sapiens 8-18 18558494-4 2008 This activity of ClfA (ClfA(221-550)) was produced in fusion to the C-terminus of glutathione-S-transferase (GST) with recombinant technology and used as an affinity ligand to capture plasma fibrinogen. clfa 17-21 fibrinogen beta chain Homo sapiens 191-201 19024566-0 2008 Disturbance of functional properties of fibrinogen under ozone oxidation. Ozone 57-62 fibrinogen beta chain Homo sapiens 40-50 18846775-6 2008 On the other hand, correlation analysis also showed a positive significant association between the fibrinogen levels and total cholesterol (p < 0.02), dependent of individuals with family history of ischaemic cardiovascular disease (total cholesterol: p < 0.02 and LDL-C: p < 0.003). Cholesterol 127-138 fibrinogen beta chain Homo sapiens 99-109 18846775-6 2008 On the other hand, correlation analysis also showed a positive significant association between the fibrinogen levels and total cholesterol (p < 0.02), dependent of individuals with family history of ischaemic cardiovascular disease (total cholesterol: p < 0.02 and LDL-C: p < 0.003). Cholesterol 242-253 fibrinogen beta chain Homo sapiens 99-109 18846775-7 2008 In consideration of the high concentrations of fibrinogen found in 31.7% of apparently healthy men and their significant positive correlation with total cholesterol and LDL-C, on the group of men with a family history of ischaemic cardiovascular disease, it would be advisable to include the determination of fibrinogen in the cardiovascular evaluation of these particular subjects. Cholesterol 153-164 fibrinogen beta chain Homo sapiens 47-57 18846775-7 2008 In consideration of the high concentrations of fibrinogen found in 31.7% of apparently healthy men and their significant positive correlation with total cholesterol and LDL-C, on the group of men with a family history of ischaemic cardiovascular disease, it would be advisable to include the determination of fibrinogen in the cardiovascular evaluation of these particular subjects. ldl-c 169-174 fibrinogen beta chain Homo sapiens 47-57 18583356-4 2008 The citrullinated form of fibrinogen appears in rheumatoid arthritis synovial tissue together with the production of autoantibodies that target self-peptides containing citrulline. Citrulline 169-179 fibrinogen beta chain Homo sapiens 26-36 18564219-3 2008 It is well established that in the presence of thrombin-activated factor XIII (FXIIIa), alpha2AP becomes covalently ligated to the distal alpha chains of fibrin or fibrinogen at lysine 303 (two potential sites per molecule). Lysine 178-184 fibrinogen beta chain Homo sapiens 164-174 18564219-5 2008 That singular observation led to our hypothesis that native plasma factor XIII (FXIII), which is known to catalyze covalent cross-linking of fibrinogen in the presence of calcium ions, can also incorporate alpha2AP into fibrinogen in the circulation. Calcium 171-178 fibrinogen beta chain Homo sapiens 141-151 18558494-4 2008 This activity of ClfA (ClfA(221-550)) was produced in fusion to the C-terminus of glutathione-S-transferase (GST) with recombinant technology and used as an affinity ligand to capture plasma fibrinogen. clfa 23-27 fibrinogen beta chain Homo sapiens 191-201 18558494-7 2008 After washing out unbound proteins, column-captured fibrinogen was specifically eluted down with a citrate buffer solution (50mM, pH 5.6). Citric Acid 99-106 fibrinogen beta chain Homo sapiens 52-62 18558494-8 2008 Purified human fibrinogen exhibited the ability to support platelet adhesion and aggregation and formed fibrin clot by thrombin, indicating that ClfA(221-550)-purified human fibrinogen is a functionally active product. clfa 145-149 fibrinogen beta chain Homo sapiens 15-25 18558494-8 2008 Purified human fibrinogen exhibited the ability to support platelet adhesion and aggregation and formed fibrin clot by thrombin, indicating that ClfA(221-550)-purified human fibrinogen is a functionally active product. clfa 145-149 fibrinogen beta chain Homo sapiens 174-184 18558494-10 2008 By virtue of its simplicity and feasibility, ClfA(221-550)-based method would be very useful to the investigators who need fibrinogen to perform their studies. clfa 45-49 fibrinogen beta chain Homo sapiens 123-133 18710925-2 2008 alpha(v)beta(3) binds fibrinogen via an Arg-Asp-Gly (RGD) motif in fibrinogen"s alpha subunit. Arginine 40-44 fibrinogen beta chain Homo sapiens 22-32 18616311-3 2008 These probes were used to collect force measurements between the antibody and fibrinogen on mica substrates and the probability of antigen recognition was calculated. mica 92-96 fibrinogen beta chain Homo sapiens 78-88 18616311-5 2008 Macroscale platelet adhesion measurements on these mica substrates were determined to be greatest at fibrinogen residence times of approximately 45 min, which correlated well with the functional activity of adsorbed fibrinogen as measured by the modified AFM probes. mica 51-55 fibrinogen beta chain Homo sapiens 101-111 18616311-5 2008 Macroscale platelet adhesion measurements on these mica substrates were determined to be greatest at fibrinogen residence times of approximately 45 min, which correlated well with the functional activity of adsorbed fibrinogen as measured by the modified AFM probes. mica 51-55 fibrinogen beta chain Homo sapiens 216-226 18710925-2 2008 alpha(v)beta(3) binds fibrinogen via an Arg-Asp-Gly (RGD) motif in fibrinogen"s alpha subunit. Arginine 40-44 fibrinogen beta chain Homo sapiens 67-77 18710925-2 2008 alpha(v)beta(3) binds fibrinogen via an Arg-Asp-Gly (RGD) motif in fibrinogen"s alpha subunit. aspartylglycine 44-51 fibrinogen beta chain Homo sapiens 22-32 18710925-2 2008 alpha(v)beta(3) binds fibrinogen via an Arg-Asp-Gly (RGD) motif in fibrinogen"s alpha subunit. aspartylglycine 44-51 fibrinogen beta chain Homo sapiens 67-77 18093595-4 2008 RESULTS: Phosphorus levels were significantly associated with age, female gender, diabetes mellitus, hypertension, hypercholesterolemia and fibrinogen levels (p < 0.0001 for each), but not with estimated glomerular filtration rate (eGFR). Phosphorus 9-19 fibrinogen beta chain Homo sapiens 140-150 18433459-4 2008 RESULTS: Here we show that BPA is a potent fibrinogenolytic agent in vitro, as it readily degraded human and rat fibrinogen at a very low enzyme concentration. bisphenol A 27-30 fibrinogen beta chain Homo sapiens 43-53 18080768-9 2008 Circulating ghrelin levels in UC and CD patients were positively correlated with sedimentation, fibrinogen and CRP and was negatively correlated with IGF-1, BMI, TSFT, MAC, fat mass (%), and fat free mass (%). Ghrelin 12-19 fibrinogen beta chain Homo sapiens 96-106 18485090-0 2008 A new electrophoretic variant of fibrinogen associated with venous thromboembolism, fibrinogen Bordeaux Aalpha Arg439-->Cys. Cysteine 123-126 fibrinogen beta chain Homo sapiens 33-43 18485090-0 2008 A new electrophoretic variant of fibrinogen associated with venous thromboembolism, fibrinogen Bordeaux Aalpha Arg439-->Cys. Cysteine 123-126 fibrinogen beta chain Homo sapiens 84-94 18433459-5 2008 Partially N-deglycosylated BPA (p-N-d-BPA) generated similar fibrinogen products, but with enhanced fibrinogenolytic activity. bisphenol A 27-30 fibrinogen beta chain Homo sapiens 61-71 18799407-9 2008 These involve opening and removing of the haematoma, haemostasis with Argon coagulation, which resulted in an adherent Glisson"s capsule to the parenchyma and covering with collagen fleece coated with fibrinogen and thrombin. Argon 70-75 fibrinogen beta chain Homo sapiens 201-211 18445610-8 2008 Tirofiban significantly inhibited SPA, fib (2, 4, 8 g/L), ADP, ADP + fib combination, and 5HT-induced aggregation. Adenosine Diphosphate 58-61 fibrinogen beta chain Homo sapiens 4-7 20157362-5 2008 The hypothesis was that etoricoxib would be non-inferior or superior to placebo in effect on C-reactive protein (CRP), LDL-cholesterol, homocysteine, and fibrinogen. Etoricoxib 24-34 fibrinogen beta chain Homo sapiens 154-164 18505438-6 2008 Elevated rates of L-arginine transport in Dengue fever patients were associated with enhanced NO synthase activity and elevated plasma fibrinogen levels. Arginine 18-28 fibrinogen beta chain Homo sapiens 135-145 18511036-4 2008 In the present study, we found three peculiar characteristics of porcine polymorphonuclear leukocyte that had been induced to spread over fibrinogen-coated surfaces by phorbol 12-myristate 13-acetate (PMA) in acidified medium. Tetradecanoylphorbol Acetate 168-199 fibrinogen beta chain Homo sapiens 138-148 18511036-4 2008 In the present study, we found three peculiar characteristics of porcine polymorphonuclear leukocyte that had been induced to spread over fibrinogen-coated surfaces by phorbol 12-myristate 13-acetate (PMA) in acidified medium. Tetradecanoylphorbol Acetate 201-204 fibrinogen beta chain Homo sapiens 138-148 18445610-8 2008 Tirofiban significantly inhibited SPA, fib (2, 4, 8 g/L), ADP, ADP + fib combination, and 5HT-induced aggregation. Serotonin 90-93 fibrinogen beta chain Homo sapiens 4-7 18799820-8 2008 Perindopril significantly reduced plasma levels of oxidized LDLs, CRP, MCP-1, fibrinogen and PAI-1, and increased interleukin-10. Perindopril 0-11 fibrinogen beta chain Homo sapiens 78-88 20641887-19 2004 A tripeptide sequence comprising Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins including alphavbeta3. tripeptide K-26 2-12 fibrinogen beta chain Homo sapiens 146-156 18387312-2 2008 Human plasma fibrinogen is a dimeric molecule comprising two sets of three different polypeptides (Aalpha, 66kDa; Bbeta, 55kDa; gamma, 48kDa). bbeta 114-119 fibrinogen beta chain Homo sapiens 13-23 18387312-7 2008 The Bbeta chain of the recombinant fibrinogen was N-glycosylated but the Aalpha chain, as in plasma fibrinogen, was not. bbeta 4-9 fibrinogen beta chain Homo sapiens 35-45 18387312-7 2008 The Bbeta chain of the recombinant fibrinogen was N-glycosylated but the Aalpha chain, as in plasma fibrinogen, was not. Nitrogen 50-51 fibrinogen beta chain Homo sapiens 35-45 18521501-0 2008 Fibrinogen Hershey IV: a novel dysfibrinogen with a gammaV411I mutation in the integrin alpha(IIb)beta(3) binding site. beta(3) 98-105 fibrinogen beta chain Homo sapiens 0-10 17896776-4 2008 On the blends of copolymers with PEO blocks of MW 2000 and 5000, fibrinogen adsorption from physiologic buffer decreased with increasing copolymer content up to 20 wt%. copolymers 17-27 fibrinogen beta chain Homo sapiens 65-75 17896776-4 2008 On the blends of copolymers with PEO blocks of MW 2000 and 5000, fibrinogen adsorption from physiologic buffer decreased with increasing copolymer content up to 20 wt%. copolymer 17-26 fibrinogen beta chain Homo sapiens 65-75 17896776-8 2008 At low copolymer content (< or =10 wt %), fibrinogen adsorption decreased with decreasing PEO block length. copolymer 7-16 fibrinogen beta chain Homo sapiens 45-55 18342366-2 2008 To investigate this topic, a unique biomaterial system based on poly(ethylene glycol)-conjugated fibrinogen was adapted to study phenotypic plasticity in smooth muscle cells (SMCs) as a function of ECM mechanics in 3-D. Tuning the compressive modulus between 448 and 5804 Pa modestly regulated SMC cytoskeletal assembly in 3-D, with spread cells in stiff matrices having a slightly higher degree of F-actin bundling after prolonged culture. Polyethylene Glycols 64-85 fibrinogen beta chain Homo sapiens 97-107 20641887-19 2004 A tripeptide sequence comprising Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins including alphavbeta3. arginyl-glycyl-aspartic acid 33-44 fibrinogen beta chain Homo sapiens 146-156 18446250-0 2008 Adsorption of fibrinogen on a biomedical-grade stainless steel 316LVM surface: a PM-IRRAS study of the adsorption thermodynamics, kinetics and secondary structure changes. Stainless Steel 47-62 fibrinogen beta chain Homo sapiens 14-24 18492281-8 2008 Leakiness of BBB was indicated by infiltration of Evans blue dye and plasma protein fibrinogen into QUIN-injected striatum with barrier permeability restored by 62% (Evans blue permeability) and 49% (fibrinogen permeability) with Cyclo-VEGI application. Quinolinic Acid 100-104 fibrinogen beta chain Homo sapiens 84-94 18492281-8 2008 Leakiness of BBB was indicated by infiltration of Evans blue dye and plasma protein fibrinogen into QUIN-injected striatum with barrier permeability restored by 62% (Evans blue permeability) and 49% (fibrinogen permeability) with Cyclo-VEGI application. Quinolinic Acid 100-104 fibrinogen beta chain Homo sapiens 200-210 18446250-1 2008 Polarization-modulation infrared reflection-absorption spectroscopy (PM-IRRAS) was employed to investigate the interaction of serum protein fibrinogen with a biomedical-grade 316LVM stainless steel surface, in terms of the adsorption thermodynamics, kinetics and secondary structure changes of the protein. Stainless Steel 182-197 fibrinogen beta chain Homo sapiens 140-150 18446250-4 2008 Deconvolution of the amide I bands indicated that the adsorption of fibrinogen on 316LVM results in significant changes in the protein"s secondary structure that occur predominantly within the first minute of adsorption. Amides 21-26 fibrinogen beta chain Homo sapiens 68-78 18083324-7 2008 These results suggest that fibrinogen and fibronectin facilitate the adherence of conidia to A549 cells probably through the interaction with adhesin-type molecules or a sialic acid based recognition system. N-Acetylneuraminic Acid 170-181 fibrinogen beta chain Homo sapiens 27-37 18330493-1 2008 OBJECTIVE: In this study, we tested in patients with metabolic syndrome whether allopurinol through decreasing oxidative stress improves endothelial function, and ameliorates inflammatory state represented by markers of myeloperoxidase, C-reactive protein (CRP) and fibrinogen. Allopurinol 80-91 fibrinogen beta chain Homo sapiens 266-276 18305548-6 2008 On the other hand, a decrease of plasma sEPCR and fibrinogen level (P<0.05, respectively) after 1 month of therapy by telmisartan was found. Telmisartan 121-132 fibrinogen beta chain Homo sapiens 50-60 18792624-10 2008 The children with the valproate therapy have lower approximate values of the number of platelets, fibrinogen and platelet aggregation in comparison with healthy children, but they have a higher approximate value of bleeding time and prothrombin time. Valproic Acid 22-31 fibrinogen beta chain Homo sapiens 98-108 18160616-2 2008 This study investigated whether fibrinogen receptor GpIIb/IIIa is also the binding site for low-density lipoprotein (LDL) in platelets by using GpIIb/IIIa-coated polystyrene microbeads incubated with various concentrations of fluorescein isothiocyanate (FITC)-labeled ligands. Fluorescein-5-isothiocyanate 226-252 fibrinogen beta chain Homo sapiens 32-42 17869258-13 2008 PMNL priming and fibrinogen levels correlated positively with the severity of hyperlipidemia (r=0.32, P=0.02 for CD11b vs. cholesterol and r=0.38, P=0.009 for CD11b vs. LDL-c; r=0.35, P=0.01 for fibrinogen vs. cholesterol and r=0.3, P=0.03 for superoxide release vs. LDL-c). Cholesterol 123-134 fibrinogen beta chain Homo sapiens 17-27 17869258-13 2008 PMNL priming and fibrinogen levels correlated positively with the severity of hyperlipidemia (r=0.32, P=0.02 for CD11b vs. cholesterol and r=0.38, P=0.009 for CD11b vs. LDL-c; r=0.35, P=0.01 for fibrinogen vs. cholesterol and r=0.3, P=0.03 for superoxide release vs. LDL-c). ldl-c 169-174 fibrinogen beta chain Homo sapiens 17-27 17869258-13 2008 PMNL priming and fibrinogen levels correlated positively with the severity of hyperlipidemia (r=0.32, P=0.02 for CD11b vs. cholesterol and r=0.38, P=0.009 for CD11b vs. LDL-c; r=0.35, P=0.01 for fibrinogen vs. cholesterol and r=0.3, P=0.03 for superoxide release vs. LDL-c). Cholesterol 210-221 fibrinogen beta chain Homo sapiens 17-27 17869258-13 2008 PMNL priming and fibrinogen levels correlated positively with the severity of hyperlipidemia (r=0.32, P=0.02 for CD11b vs. cholesterol and r=0.38, P=0.009 for CD11b vs. LDL-c; r=0.35, P=0.01 for fibrinogen vs. cholesterol and r=0.3, P=0.03 for superoxide release vs. LDL-c). Superoxides 244-254 fibrinogen beta chain Homo sapiens 17-27 17869258-13 2008 PMNL priming and fibrinogen levels correlated positively with the severity of hyperlipidemia (r=0.32, P=0.02 for CD11b vs. cholesterol and r=0.38, P=0.009 for CD11b vs. LDL-c; r=0.35, P=0.01 for fibrinogen vs. cholesterol and r=0.3, P=0.03 for superoxide release vs. LDL-c). ldl-c 267-272 fibrinogen beta chain Homo sapiens 17-27 18160616-2 2008 This study investigated whether fibrinogen receptor GpIIb/IIIa is also the binding site for low-density lipoprotein (LDL) in platelets by using GpIIb/IIIa-coated polystyrene microbeads incubated with various concentrations of fluorescein isothiocyanate (FITC)-labeled ligands. Polystyrenes 162-173 fibrinogen beta chain Homo sapiens 32-42 18160616-2 2008 This study investigated whether fibrinogen receptor GpIIb/IIIa is also the binding site for low-density lipoprotein (LDL) in platelets by using GpIIb/IIIa-coated polystyrene microbeads incubated with various concentrations of fluorescein isothiocyanate (FITC)-labeled ligands. Fluorescein-5-isothiocyanate 254-258 fibrinogen beta chain Homo sapiens 32-42 18160616-4 2008 Binding of fibrinogen (Fg)-FITC and LDL-FITC to GpIIb/IIIa coated microbeads was concentration dependent, reaching saturation. Fluorescein-5-isothiocyanate 27-31 fibrinogen beta chain Homo sapiens 11-21 18160616-4 2008 Binding of fibrinogen (Fg)-FITC and LDL-FITC to GpIIb/IIIa coated microbeads was concentration dependent, reaching saturation. ldl-fitc 36-44 fibrinogen beta chain Homo sapiens 11-21 18160616-5 2008 Binding of LDL-FITC to GpIIb/IIIa coated microbeads was inhibited by fibrinogen. ldl-fitc 11-19 fibrinogen beta chain Homo sapiens 69-79 18316072-9 2008 Epsilon-aminocaproic acid limited bead-cell complexation, suggesting fibrinogen degradation products modulate dendritic cell activity. Aminocaproic Acid 0-25 fibrinogen beta chain Homo sapiens 69-79 18395553-8 2008 Fibrinogen vasorelaxations were completely inhibited by abciximab and diminished by endothelial denudation and treatment with the nitric oxide synthase inhibitor L-nitroargininemethylester and glibenclamide (P < .01). NG-Nitroarginine Methyl Ester 162-188 fibrinogen beta chain Homo sapiens 0-10 18395553-8 2008 Fibrinogen vasorelaxations were completely inhibited by abciximab and diminished by endothelial denudation and treatment with the nitric oxide synthase inhibitor L-nitroargininemethylester and glibenclamide (P < .01). Glyburide 193-206 fibrinogen beta chain Homo sapiens 0-10 18356600-8 2008 Patients taking indinavir boosted with ritonavir had median fibrinogen levels 8% higher than those on indinavir alone (P = 0.049). Indinavir 16-25 fibrinogen beta chain Homo sapiens 60-70 17688261-0 2008 Fibrinogen adsorption onto 316L stainless steel under polarized conditions. Stainless Steel 32-47 fibrinogen beta chain Homo sapiens 0-10 17688261-1 2008 Adsorption of the plasma protein fibrinogen onto electrically polarized 316L stainless steel was observed and quantified using both in situ and ex situ atomic force microscopy (AFM) techniques. Stainless Steel 77-92 fibrinogen beta chain Homo sapiens 33-43 17562129-6 2008 RESULTS: Higher serum cortisol levels predicted higher fibrinogen (beta = .17, P = .001) and higher von Willebrand factor (beta = .16, P = .008), all independently of covariates, including C-reactive protein, which was also an independent predictor of fibrinogen (beta = .20, P = .001) and von Willebrand factor (beta = .16, P = .004). Hydrocortisone 22-30 fibrinogen beta chain Homo sapiens 55-65 17562129-6 2008 RESULTS: Higher serum cortisol levels predicted higher fibrinogen (beta = .17, P = .001) and higher von Willebrand factor (beta = .16, P = .008), all independently of covariates, including C-reactive protein, which was also an independent predictor of fibrinogen (beta = .20, P = .001) and von Willebrand factor (beta = .16, P = .004). Hydrocortisone 22-30 fibrinogen beta chain Homo sapiens 252-262 18458510-7 2008 GSNO was also shown to preserve the aggregability of frozen platelets because in the presence of GSNO the delta percent change of P-selectin expression and fibrinogen binding of frozen platelets increased significantly irrelevant to DMSO. S-Nitrosoglutathione 0-4 fibrinogen beta chain Homo sapiens 156-166 18401237-6 2008 Logistic regression analysis modeling for low-density lipoprotein cholesterol, lipoprotein(a), fibrinogen, and homocysteine showed that homocysteine value (P=.016) was an independent predictor of the primary combined end point. Homocysteine 136-148 fibrinogen beta chain Homo sapiens 95-105 18392327-2 2008 One proposed mechanism for this is non-enzymatic glycation of fibrinogen due to high blood glucose. Glucose 91-98 fibrinogen beta chain Homo sapiens 62-72 18392327-7 2008 There was a significant decrease in fibrinogen glycation (6.81 to 5.02 mol glucose/mol fibrinogen) with a corresponding decrease in rate of lateral aggregation (5.86 to 4.62) and increased permeability (2.45 to 2.85 x 10(-8) cm(2)) and lysis rate (3.08 to 3.27 microm/min) in the diabetic subjects after glycaemic control. Glucose 75-82 fibrinogen beta chain Homo sapiens 36-46 18392327-7 2008 There was a significant decrease in fibrinogen glycation (6.81 to 5.02 mol glucose/mol fibrinogen) with a corresponding decrease in rate of lateral aggregation (5.86 to 4.62) and increased permeability (2.45 to 2.85 x 10(-8) cm(2)) and lysis rate (3.08 to 3.27 microm/min) in the diabetic subjects after glycaemic control. Glucose 75-82 fibrinogen beta chain Homo sapiens 87-97 18356600-8 2008 Patients taking indinavir boosted with ritonavir had median fibrinogen levels 8% higher than those on indinavir alone (P = 0.049). Ritonavir 39-48 fibrinogen beta chain Homo sapiens 60-70 18356600-9 2008 Lower levels of fibrinogen were seen in those HIV-infected patients currently using any nonnucleoside reverse transcriptase inhibitor (NNRTI) compared to those not using an NNRTI (nevirapine -14.4%, P < 0.0001; efavirenz -7%, P = 0.0002). Nevirapine 180-190 fibrinogen beta chain Homo sapiens 16-26 18356600-10 2008 The associations of ritonavir, indinavir, efavirenz and nevirapine with fibrinogen levels persisted after multivariable analysis and were independent of other antiretroviral use. Ritonavir 20-29 fibrinogen beta chain Homo sapiens 72-82 18356600-10 2008 The associations of ritonavir, indinavir, efavirenz and nevirapine with fibrinogen levels persisted after multivariable analysis and were independent of other antiretroviral use. Indinavir 31-40 fibrinogen beta chain Homo sapiens 72-82 18193901-0 2008 Interaction of human plasma fibrinogen with commercially pure titanium as studied with atomic force microscopy and X-ray photoelectron spectroscopy. Titanium 62-70 fibrinogen beta chain Homo sapiens 28-38 18193901-6 2008 The main goal of this study was to investigate the conformation of human plasma fibrinogen (HPF) adsorbed on commercially pure titanium (CP Ti) on a molecular level by means of ex situ atomic force microscopy (AFM). Titanium 127-135 fibrinogen beta chain Homo sapiens 80-90 18436984-0 2008 The effects of nitronium ion on nitration, carbonylation and coagulation of human fibrinogen. nitronium 15-24 fibrinogen beta chain Homo sapiens 82-92 18436984-1 2008 The effect of nitronium ion on nitration, carbonylation and coagulation of human fibrinogen (Fg) in vitro was investigated. nitronium 14-23 fibrinogen beta chain Homo sapiens 81-91 18289163-6 2008 Subjects on melatonin had significantly lower mean levels of FVIII:C (81%, 95% CI 71-92 versus 103%, 95% CI 90-119; P = 0.018) and of fibrinogen (1.92 g/L, 95% CI 1.76-2.08 versus 2.26 g/L, 95% CI 2.09-2.43; P = 0.007) than those on placebo explaining 14 and 17% of the respective variance. Melatonin 12-21 fibrinogen beta chain Homo sapiens 134-144 18289163-7 2008 In all subjects, increased plasma melatonin concentration independently predicted lower levels of FVIII:C (P = 0.037) and fibrinogen (P = 0.022) explaining 9 and 11% of the respective variance. Melatonin 34-43 fibrinogen beta chain Homo sapiens 122-132 17623246-1 2008 BACKGROUND: Plasma hyaluronan binds to fibrinogen, affecting intravascular fibrin polymerization and fibrin clot formation. Hyaluronic Acid 19-29 fibrinogen beta chain Homo sapiens 39-49 18294856-7 2008 AFM data show that varying pH and calcium ion concentrations alters the mechanical resilience of fibrinogen. Calcium 34-41 fibrinogen beta chain Homo sapiens 97-107 17920250-5 2008 However, fibrinogen and albumin adsorption significantly increased on all surfaces after PEG or MPEG backfilling. Polyethylene Glycols 89-92 fibrinogen beta chain Homo sapiens 9-19 17920250-5 2008 However, fibrinogen and albumin adsorption significantly increased on all surfaces after PEG or MPEG backfilling. methyl cellosolve 96-100 fibrinogen beta chain Homo sapiens 9-19 18372583-4 2008 METHODS AND RESULTS: The association between alcohol consumption and concentrations of high sensitivity C-reactive protein (hs-CRP) and fibrinogen were investigated. Alcohols 45-52 fibrinogen beta chain Homo sapiens 136-146 18372583-8 2008 Daily alcohol intake showed an apparent U-shaped association with hs-CRP and fibrinogen values in men, with lowest levels at an alcohol intake of 20-70 g daily (0.139 +/- 0.116 mg/dl for hs-CRP and 274 +/- 51.7 mg/dl for fibrinogen). Alcohols 6-13 fibrinogen beta chain Homo sapiens 77-87 18372583-8 2008 Daily alcohol intake showed an apparent U-shaped association with hs-CRP and fibrinogen values in men, with lowest levels at an alcohol intake of 20-70 g daily (0.139 +/- 0.116 mg/dl for hs-CRP and 274 +/- 51.7 mg/dl for fibrinogen). Alcohols 6-13 fibrinogen beta chain Homo sapiens 221-231 18240236-12 2008 Concordance index (C statistic) analyses showed that uric acid significantly improved the predictive accuracy of a model that included Framingham Heart Study score factors, metabolic syndrome components, and fibrinogen levels. Uric Acid 53-62 fibrinogen beta chain Homo sapiens 208-218 18220347-6 2008 Finally, surface plasmon resonance (SPR) sensograms demonstrated that both P(OMe)CL and the P(OMe)CL-b-PCL block copolymers exhibit excellent resistance to fibrinogen and lysozyme. p(ome)cl 75-83 fibrinogen beta chain Homo sapiens 156-166 18220347-6 2008 Finally, surface plasmon resonance (SPR) sensograms demonstrated that both P(OMe)CL and the P(OMe)CL-b-PCL block copolymers exhibit excellent resistance to fibrinogen and lysozyme. cl-b-pcl block copolymers 98-123 fibrinogen beta chain Homo sapiens 156-166 18634269-2 2008 Results in the literature growing evidence is pointing to the following effects of ethanol or its metabolites: partial platelet activation generating poorly functioning platelets, decreased levels of fibrinogen and selected other factors, and increased fibrinolysis. Ethanol 83-90 fibrinogen beta chain Homo sapiens 200-210 17803696-6 2008 We found glycohaemoglobin to be a significant determinant of fibrinogen concentrations in apparently healthy nondiabetic individuals not yet presenting with evident atherothrombosis. glycohaemoglobin 9-25 fibrinogen beta chain Homo sapiens 61-71 18191049-5 2008 Significant race and high-density lipoprotein cholesterol interactions were found for fibrinogen (P = .021); and significant race and waist to hip ratio (P = .015), diastolic blood pressure (P = .013), and insulin (P = .037) interactions were found for PAI-1. density lipoprotein cholesterol 26-57 fibrinogen beta chain Homo sapiens 86-96 18077134-3 2008 We determined whether a Zn supplementation, which increases serum Zn concentration and Zn exchangeable pool mass, modifies whole-body protein turnover and albumin and fibrinogen synthesis rates in late-middle-aged men. Zinc 24-26 fibrinogen beta chain Homo sapiens 167-177 18709301-9 2008 Folic acid levels correlated inversely with homocysteine and positively with fibrinogen levels. Folic Acid 0-10 fibrinogen beta chain Homo sapiens 77-87 18000162-3 2008 OBJECTIVE: To evaluate the efficacy of atorvastatin compared with a control group in inducing changes in lipoprotein(a) [Lp(a)], apolipoprotein (Apo) A-1, Apo-B, and fibrinogen levels, as well as the conventional lipoprotein profile, in hemodialysis patients over 36 weeks; secondary objectives were to assess changes in C-reactive protein, albumin, and safety measures. Atorvastatin 39-51 fibrinogen beta chain Homo sapiens 166-176 18180617-5 2008 In the present study, the effect of lysine or cyanogen bromide-treated fibrinogen, alone or in combination with the oversulfated compounds, on the activation of glutamic plasminogen by tissue plasminogen activator was investigated. Cyanogen Bromide 46-62 fibrinogen beta chain Homo sapiens 71-81 18198402-4 2008 Fibrinogen adsorption to Nitinol surfaces ranged from that characteristic to pure Ni (130 ng/cm(2)) to pure Ti (300 ng/cm(2)). nitinol 25-32 fibrinogen beta chain Homo sapiens 0-10 18198402-4 2008 Fibrinogen adsorption to Nitinol surfaces ranged from that characteristic to pure Ni (130 ng/cm(2)) to pure Ti (300 ng/cm(2)). Titanium 108-110 fibrinogen beta chain Homo sapiens 0-10 18436984-1 2008 The effect of nitronium ion on nitration, carbonylation and coagulation of human fibrinogen (Fg) in vitro was investigated. nitronium 14-23 fibrinogen beta chain Homo sapiens 93-95 18436984-5 2008 Higher concentrations of NO2BF4 (1 and 0.1 mmol/l) triggered growth of nitration and carbonylation of Fg, but led to inhibition of polymerization. no2bf4 25-31 fibrinogen beta chain Homo sapiens 102-104 20408656-0 2008 Measurement of interaction forces between fibrinogen coated probes and mica surface with the atomic force microscope: The pH and ionic strength effect. mica 71-75 fibrinogen beta chain Homo sapiens 42-52 20408656-2 2008 The authors have used atomic force microscopy (AFM) to directly measure the force of attraction/adhesion of fibrinogen coated tips to mica surfaces and reveal the effect of the surrounding solution pH and ionic strength on this interaction. mica 134-138 fibrinogen beta chain Homo sapiens 108-118 20408656-3 2008 Silica colloid spheres were attached to the AFM cantilevers and, after plasma deposition of poly(acrylic acid), fibrinogen molecules were covalently bound on them with the help of the cross-linker 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC) in the presence of N-hydroxysulfosuccinimide (sulfo-NHS). Silicon Dioxide 0-6 fibrinogen beta chain Homo sapiens 112-122 20408656-3 2008 Silica colloid spheres were attached to the AFM cantilevers and, after plasma deposition of poly(acrylic acid), fibrinogen molecules were covalently bound on them with the help of the cross-linker 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC) in the presence of N-hydroxysulfosuccinimide (sulfo-NHS). 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride 197-257 fibrinogen beta chain Homo sapiens 112-122 20408656-3 2008 Silica colloid spheres were attached to the AFM cantilevers and, after plasma deposition of poly(acrylic acid), fibrinogen molecules were covalently bound on them with the help of the cross-linker 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC) in the presence of N-hydroxysulfosuccinimide (sulfo-NHS). 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride 259-262 fibrinogen beta chain Homo sapiens 112-122 20408656-3 2008 Silica colloid spheres were attached to the AFM cantilevers and, after plasma deposition of poly(acrylic acid), fibrinogen molecules were covalently bound on them with the help of the cross-linker 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC) in the presence of N-hydroxysulfosuccinimide (sulfo-NHS). N-hydroxysulfosuccinimide 283-308 fibrinogen beta chain Homo sapiens 112-122 20408656-3 2008 Silica colloid spheres were attached to the AFM cantilevers and, after plasma deposition of poly(acrylic acid), fibrinogen molecules were covalently bound on them with the help of the cross-linker 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC) in the presence of N-hydroxysulfosuccinimide (sulfo-NHS). N-hydroxysulfosuccimide 310-319 fibrinogen beta chain Homo sapiens 112-122 20408656-4 2008 The measurements suggest that fibrinogen adsorption is controlled by the screening of electrostatic repulsion as the salt concentration increases from 15 to 150 mM, whereas at higher ionic strength (500 mM) the hydration forces and the compact molecular conformation become crucial, restricting adsorption. Salts 117-121 fibrinogen beta chain Homo sapiens 30-40 18319597-4 2008 RESULTS: Treatment of HD plasma with HCP, beyond the significant reduction of the increased levels of all the above-mentioned molecules, reduced fibrinogen, TNF-alpha, carbonylated fibrinogen and carbonylated albumin to control levels which were simultaneously found in the cryogel. hcp 37-40 fibrinogen beta chain Homo sapiens 145-155 18319597-4 2008 RESULTS: Treatment of HD plasma with HCP, beyond the significant reduction of the increased levels of all the above-mentioned molecules, reduced fibrinogen, TNF-alpha, carbonylated fibrinogen and carbonylated albumin to control levels which were simultaneously found in the cryogel. hcp 37-40 fibrinogen beta chain Homo sapiens 181-191 18180617-7 2008 Cyanogen bromide-treated fibrinogen (50 microg/ml) gave a 10-fold enhancement of activation by itself, and addition of 2.86 microg/ml oversulfated compounds amplified this to 15-fold. Cyanogen Bromide 0-16 fibrinogen beta chain Homo sapiens 25-35 18605954-0 2008 Can both EDTA and citrate plasma samples be used in measurements of fibrinogen and C-reactive protein concentrations? Edetic Acid 9-13 fibrinogen beta chain Homo sapiens 68-78 18073467-7 2008 The effects of age and glycaemic control were independent, such that there was an almost fivefold increase in risk across quintiles of fibrinogen in patients aged <60 years with below median normal glucose levels (upper quintile hazard ratio = 4.90, 95% CI = 2.79-8.58, p < 0.0001). Glucose 201-208 fibrinogen beta chain Homo sapiens 135-145 18605954-0 2008 Can both EDTA and citrate plasma samples be used in measurements of fibrinogen and C-reactive protein concentrations? Citric Acid 18-25 fibrinogen beta chain Homo sapiens 68-78 18605954-4 2008 Fibrinogen was also measured in citrate plasma using a clotting method. Citric Acid 32-39 fibrinogen beta chain Homo sapiens 0-10 18605954-5 2008 RESULTS: In approximately one-third of the samples, the fibrinogen concentration measured by immunoassay was higher in citrate plasma than in EDTA plasma, in spite of the dilution by citrate. Citric Acid 119-126 fibrinogen beta chain Homo sapiens 56-66 18239256-10 2008 RESULTS: Patients with effective ASA inhibition had significantly lower plasma fibrinogen level (p<0.05) and red blood cell aggregation values both in the heterogenous and the selected populations (p<0.01). Aspirin 33-36 fibrinogen beta chain Homo sapiens 79-89 18605954-5 2008 RESULTS: In approximately one-third of the samples, the fibrinogen concentration measured by immunoassay was higher in citrate plasma than in EDTA plasma, in spite of the dilution by citrate. Edetic Acid 142-146 fibrinogen beta chain Homo sapiens 56-66 18239256-14 2008 Thus, increased plasma fibrinogen level may play an important role in the in vitro and in vivo platelet resistance to ASA. Aspirin 118-121 fibrinogen beta chain Homo sapiens 23-33 18605954-6 2008 The immunoassay results of fibrinogen concentration measurements in EDTA and citrate plasma differed significantly and also differed from those of functionally measured fibrinogen concentrations. Edetic Acid 68-72 fibrinogen beta chain Homo sapiens 27-37 18605954-6 2008 The immunoassay results of fibrinogen concentration measurements in EDTA and citrate plasma differed significantly and also differed from those of functionally measured fibrinogen concentrations. Citric Acid 77-84 fibrinogen beta chain Homo sapiens 27-37 18605954-11 2008 Fibrinogen concentrations should preferably be measured functionally in citrate plasma. Citric Acid 72-79 fibrinogen beta chain Homo sapiens 0-10 18334738-3 2008 Both FGB variants, -455G>A and -148C>T were in complete linkage disequilibrium and were associated with higher levels of plasma fibrinogen and 2-h glucose after a 75-g oral glucose load (p<0.01). Glucose 153-160 fibrinogen beta chain Homo sapiens 5-8 19126992-0 2008 Relation of platelet aggregation and fibrinogen levels to advancing age in aspirin- and thienopyridine-treated patients. Aspirin 75-82 fibrinogen beta chain Homo sapiens 37-47 19126992-0 2008 Relation of platelet aggregation and fibrinogen levels to advancing age in aspirin- and thienopyridine-treated patients. thienopyridine 88-102 fibrinogen beta chain Homo sapiens 37-47 19126992-7 2008 In aspirin-treated patients also fibrinogen levels increased with aging (p<0.001). Aspirin 3-10 fibrinogen beta chain Homo sapiens 33-43 19126992-9 2008 Thienopyridine-treated patients exhibited significantly lower fibrinogen levels than ASA-treated individuals (p<0.001). thienopyridine 0-14 fibrinogen beta chain Homo sapiens 62-72 18334738-3 2008 Both FGB variants, -455G>A and -148C>T were in complete linkage disequilibrium and were associated with higher levels of plasma fibrinogen and 2-h glucose after a 75-g oral glucose load (p<0.01). Glucose 179-186 fibrinogen beta chain Homo sapiens 5-8 18334738-3 2008 Both FGB variants, -455G>A and -148C>T were in complete linkage disequilibrium and were associated with higher levels of plasma fibrinogen and 2-h glucose after a 75-g oral glucose load (p<0.01). Glucose 179-186 fibrinogen beta chain Homo sapiens 134-144 18334738-4 2008 Carriers of FGB AC-haplotype, comprising the two nucleotide variants at positions -455 and -249, had higher fibrinogen level (2.64 +/- 0.65 vs 2.42 +/- 0.52 g/L, p=0.002) and 2-h glucose after a 75-g oral glucose load (5.87 +/- 1.14 vs 5.47 +/- 1.22 g/L, p=0.006). Glucose 179-186 fibrinogen beta chain Homo sapiens 12-15 18334738-4 2008 Carriers of FGB AC-haplotype, comprising the two nucleotide variants at positions -455 and -249, had higher fibrinogen level (2.64 +/- 0.65 vs 2.42 +/- 0.52 g/L, p=0.002) and 2-h glucose after a 75-g oral glucose load (5.87 +/- 1.14 vs 5.47 +/- 1.22 g/L, p=0.006). Glucose 205-212 fibrinogen beta chain Homo sapiens 12-15 18310964-9 2008 Plasma insulin as well as fibrinogen were significantly reduced by delapril/manidipine (-17.8 pmol/l, p=0.047 and -67.5 mg/dl, p=0.021, respectively), but not by olmesartan/HCTZ, the difference between the two treatments being statistically significant (p <0.05). delapril 67-75 fibrinogen beta chain Homo sapiens 26-36 18310964-9 2008 Plasma insulin as well as fibrinogen were significantly reduced by delapril/manidipine (-17.8 pmol/l, p=0.047 and -67.5 mg/dl, p=0.021, respectively), but not by olmesartan/HCTZ, the difference between the two treatments being statistically significant (p <0.05). manidipine 76-86 fibrinogen beta chain Homo sapiens 26-36 18310964-10 2008 CONCLUSION: In obese hypertensive patients the delapril/manidipine combination but not the olmesartan/HCTZ combination significantly decreased insulin resistance and plasma fibrinogen levels, despite the similar BP lowering efficacy. delapril 47-55 fibrinogen beta chain Homo sapiens 173-183 18310964-10 2008 CONCLUSION: In obese hypertensive patients the delapril/manidipine combination but not the olmesartan/HCTZ combination significantly decreased insulin resistance and plasma fibrinogen levels, despite the similar BP lowering efficacy. manidipine 56-66 fibrinogen beta chain Homo sapiens 173-183 17949478-11 2008 RNAi-mediated knockdown of FGG expression resulted in decreased production of fibrinogen protein and inhibited (3)H-thymidine uptake in A549 and PC-3 cells by 60%, which was restored by exogenously added fibrinogen. Thymidine 116-125 fibrinogen beta chain Homo sapiens 204-214 18854129-0 2008 Fibrinogen and von Willebrand factor mediated platelet adhesion to polystyrene under flow conditions. Polystyrenes 67-78 fibrinogen beta chain Homo sapiens 0-10 18209575-5 2008 These data suggest that thiol-disulfide exchange permits reduction of disulfide groups in thrombin and fibrinogen, altering their tertiary structure and physiological function. Sulfhydryl Compounds 24-29 fibrinogen beta chain Homo sapiens 103-113 18209575-5 2008 These data suggest that thiol-disulfide exchange permits reduction of disulfide groups in thrombin and fibrinogen, altering their tertiary structure and physiological function. Disulfides 30-39 fibrinogen beta chain Homo sapiens 103-113 18209575-5 2008 These data suggest that thiol-disulfide exchange permits reduction of disulfide groups in thrombin and fibrinogen, altering their tertiary structure and physiological function. Disulfides 70-79 fibrinogen beta chain Homo sapiens 103-113 17597372-1 2008 The present work focus on the adsorption of fibrinogen (Fgn) on to the semi-interpenetrating polymer networks (IPNs) of polyethylene glycol (PEG) and poly(2-hydroxyethyl methacrylate-co-acrylonitrile) and attempts to correlate the adsorption behaviour of proteins to the blood compatible aspects of the polymeric surfaces. Polymers 93-100 fibrinogen beta chain Homo sapiens 44-54 17597372-1 2008 The present work focus on the adsorption of fibrinogen (Fgn) on to the semi-interpenetrating polymer networks (IPNs) of polyethylene glycol (PEG) and poly(2-hydroxyethyl methacrylate-co-acrylonitrile) and attempts to correlate the adsorption behaviour of proteins to the blood compatible aspects of the polymeric surfaces. Polymers 93-100 fibrinogen beta chain Homo sapiens 56-59 17597372-1 2008 The present work focus on the adsorption of fibrinogen (Fgn) on to the semi-interpenetrating polymer networks (IPNs) of polyethylene glycol (PEG) and poly(2-hydroxyethyl methacrylate-co-acrylonitrile) and attempts to correlate the adsorption behaviour of proteins to the blood compatible aspects of the polymeric surfaces. ipns 111-115 fibrinogen beta chain Homo sapiens 44-54 17597372-1 2008 The present work focus on the adsorption of fibrinogen (Fgn) on to the semi-interpenetrating polymer networks (IPNs) of polyethylene glycol (PEG) and poly(2-hydroxyethyl methacrylate-co-acrylonitrile) and attempts to correlate the adsorption behaviour of proteins to the blood compatible aspects of the polymeric surfaces. ipns 111-115 fibrinogen beta chain Homo sapiens 56-59 17597372-1 2008 The present work focus on the adsorption of fibrinogen (Fgn) on to the semi-interpenetrating polymer networks (IPNs) of polyethylene glycol (PEG) and poly(2-hydroxyethyl methacrylate-co-acrylonitrile) and attempts to correlate the adsorption behaviour of proteins to the blood compatible aspects of the polymeric surfaces. Polyethylene Glycols 120-139 fibrinogen beta chain Homo sapiens 44-54 17597372-1 2008 The present work focus on the adsorption of fibrinogen (Fgn) on to the semi-interpenetrating polymer networks (IPNs) of polyethylene glycol (PEG) and poly(2-hydroxyethyl methacrylate-co-acrylonitrile) and attempts to correlate the adsorption behaviour of proteins to the blood compatible aspects of the polymeric surfaces. Polyethylene Glycols 120-139 fibrinogen beta chain Homo sapiens 56-59 17597372-1 2008 The present work focus on the adsorption of fibrinogen (Fgn) on to the semi-interpenetrating polymer networks (IPNs) of polyethylene glycol (PEG) and poly(2-hydroxyethyl methacrylate-co-acrylonitrile) and attempts to correlate the adsorption behaviour of proteins to the blood compatible aspects of the polymeric surfaces. Polyethylene Glycols 141-144 fibrinogen beta chain Homo sapiens 44-54 17597372-1 2008 The present work focus on the adsorption of fibrinogen (Fgn) on to the semi-interpenetrating polymer networks (IPNs) of polyethylene glycol (PEG) and poly(2-hydroxyethyl methacrylate-co-acrylonitrile) and attempts to correlate the adsorption behaviour of proteins to the blood compatible aspects of the polymeric surfaces. Polyethylene Glycols 141-144 fibrinogen beta chain Homo sapiens 56-59 17597372-1 2008 The present work focus on the adsorption of fibrinogen (Fgn) on to the semi-interpenetrating polymer networks (IPNs) of polyethylene glycol (PEG) and poly(2-hydroxyethyl methacrylate-co-acrylonitrile) and attempts to correlate the adsorption behaviour of proteins to the blood compatible aspects of the polymeric surfaces. poly(2-hydroxyethyl methacrylate-co-acrylonitrile 150-199 fibrinogen beta chain Homo sapiens 44-54 17597372-1 2008 The present work focus on the adsorption of fibrinogen (Fgn) on to the semi-interpenetrating polymer networks (IPNs) of polyethylene glycol (PEG) and poly(2-hydroxyethyl methacrylate-co-acrylonitrile) and attempts to correlate the adsorption behaviour of proteins to the blood compatible aspects of the polymeric surfaces. poly(2-hydroxyethyl methacrylate-co-acrylonitrile 150-199 fibrinogen beta chain Homo sapiens 56-59 19127086-10 2008 RESULTS: Both maximal aggregation and the slope of aggregation correlate with the percentage of platelets that bound fibrinogen in response to 0.2 microM ADP. Adenosine Diphosphate 154-157 fibrinogen beta chain Homo sapiens 117-127 18373249-1 2008 Tyrosine O-sulfation was first described about 50 years ago as a post-translational modification of fibrinogen. 2-tyrosine 0-10 fibrinogen beta chain Homo sapiens 100-110 19127086-11 2008 The best correlation was seen between the slope of aggregation induced by 0.2 or 1 microM ADP and the percentage of platelets that bound fibrinogen in response to 0.2 microM ADP (for 0.2 microM r = 0.62, p = 0.038; for 1 microM r = 0.71, p = 0.025). Adenosine Diphosphate 90-93 fibrinogen beta chain Homo sapiens 137-147 19127086-11 2008 The best correlation was seen between the slope of aggregation induced by 0.2 or 1 microM ADP and the percentage of platelets that bound fibrinogen in response to 0.2 microM ADP (for 0.2 microM r = 0.62, p = 0.038; for 1 microM r = 0.71, p = 0.025). Adenosine Diphosphate 174-177 fibrinogen beta chain Homo sapiens 137-147 18853660-19 2008 The used AD (Defibrotide, Ticlide) resulted in activation of the plasma fibrynolytic system as expressed by a shortening of the ECLT, lowering of fibrinogen level and increasing FDP. defibrotide 13-24 fibrinogen beta chain Homo sapiens 146-156 18853660-19 2008 The used AD (Defibrotide, Ticlide) resulted in activation of the plasma fibrynolytic system as expressed by a shortening of the ECLT, lowering of fibrinogen level and increasing FDP. ticlide 26-33 fibrinogen beta chain Homo sapiens 146-156 17854865-3 2008 RESULTS/DISCUSSION: Based on the analyses of the patient fibrinogen and the fibrinogen genes, fibrinogen Kagoshima was shown to have the amino acid substitution of gammaThr-314 to Ile that resulted in impaired function and hypofibrinogenemia. gammathr-314 164-176 fibrinogen beta chain Homo sapiens 76-86 17854865-3 2008 RESULTS/DISCUSSION: Based on the analyses of the patient fibrinogen and the fibrinogen genes, fibrinogen Kagoshima was shown to have the amino acid substitution of gammaThr-314 to Ile that resulted in impaired function and hypofibrinogenemia. gammathr-314 164-176 fibrinogen beta chain Homo sapiens 76-86 17854865-4 2008 Polymerization of fibrin monomers derived from patient fibrinogen was severely impaired with a partial correction in the presence of calcium ions, causing very low clottability and delayed cross-linking of patient fibrin catalyzed by activated factor XIII. Calcium 133-140 fibrinogen beta chain Homo sapiens 55-65 17854865-6 2008 Additionally, tPA-mediated plasmin generation on fibrin was impaired and calcium-ion-dependent integrity of the gamma-chain D domain of Kagoshima fibrinogen was perturbed. Calcium 73-80 fibrinogen beta chain Homo sapiens 146-156 18217135-10 2008 Compared to abstainers, fibrinogen levels were decreased in individuals who consumed alcohol (maximum decrease: 0.30 g/l). Alcohols 85-92 fibrinogen beta chain Homo sapiens 24-34 18177925-9 2008 CONCLUSIONS: These results indicate that domains induced by conformational changes in adsorbed fibrinogen and fibrin are capable of activating adsorbed proenzymes and that various forms of fibrin are considerably stronger activators of the contact activation system than are adsorbed fibrinogen or a polystyrene meshwork. Polystyrenes 300-311 fibrinogen beta chain Homo sapiens 95-105 18177925-10 2008 The delayed coagulation in plasma exposed to the unmodified polystyrene meshwork can be explained by a two-step process: first, adsorption of fibrinogen, and second, activation of FXII. Polystyrenes 60-71 fibrinogen beta chain Homo sapiens 142-152 18217135-12 2008 In conclusion, alcohol consumption is associated with a reduced risk of venous thrombosis, which may be in part mediated by decreased fibrinogen levels. Alcohols 15-22 fibrinogen beta chain Homo sapiens 134-144 21086376-4 2008 When the sponge gets in contact with fluids, such as blood, lymph or saline solution, the fibrinogen and thrombin are activated and form a fibrin net able to achieve local haemostasis and tissue regeneration. Sodium Chloride 69-75 fibrinogen beta chain Homo sapiens 90-100 17726570-9 2007 CRP and fibrinogen levels decreased in all groups, but the decrease in fibrinogen level was significantly greater in insulin plus rosiglitazone group. Rosiglitazone 130-143 fibrinogen beta chain Homo sapiens 71-81 18053522-7 2007 When the sample was divided into two groups according to HDL-cholesterol levels, children with lower levels showed significantly higher values of total cholesterol/HDL-cholesterol, fibrinogen and PAI. Cholesterol 61-72 fibrinogen beta chain Homo sapiens 181-191 18219835-7 2007 There was a trend to an inverse association between exhaled nitric oxide and fibrinogen (P = .049), but this was not significant after adjusting for smoking and use of corticosteroids or after further adjustment for body mass index and atopy (P = .71). Nitric Oxide 60-72 fibrinogen beta chain Homo sapiens 77-87 20408653-3 2007 To demonstrate the potentialities of this extended approach for biointerfacial studies the authors report a series of experiments on the adsorption of the plasma protein fibrinogen at poly(octadecene-alt-maleic acid) thin films. poly(octadecene-alt-maleic acid) 184-216 fibrinogen beta chain Homo sapiens 170-180 17765302-8 2007 The acetone serves the dual purpose of precipitating and fixing the fibrinogen-based scaffolds as well as adding strength to the network during polymer bead removal. Acetone 4-11 fibrinogen beta chain Homo sapiens 68-78 18053522-8 2007 HDL-cholesterol levels were directly and significantly associated with total cholesterol and apolipoprotein A1 and negatively and significantly associated with the total cholesterol/HDL-cholesterol ratio, fibrinogen and PAI. Cholesterol 4-15 fibrinogen beta chain Homo sapiens 205-215 17937480-5 2007 MRI parameters (T2, T1, and apparent diffusion coefficient) indicated that systems with fibrinogen and thrombin (FT and MEFT) presented a structure with many and large pores, bulk water, and higher translational motion of water. Water 180-185 fibrinogen beta chain Homo sapiens 88-98 17921259-0 2007 Modified form of the fibrinogen Bbeta chain (des-Gln Bbeta), a potential long-lived marker of pancreatitis. Glutamine 48-52 fibrinogen beta chain Homo sapiens 21-31 17921259-1 2007 BACKGROUND: During an investigation of genetic variants of fibrinogen, we observed a novel form of the Bbeta chain, with a mass decrease of approximately 128 Da, in one of the controls. bbeta 103-108 fibrinogen beta chain Homo sapiens 59-69 17921259-7 2007 RESULTS: The acquired fibrinogen Bbeta chain modification was attributable to the loss of its C-terminal glutamine residue. Glutamine 105-114 fibrinogen beta chain Homo sapiens 22-32 18209575-4 2008 In thrombin-fibrinogen assays, pre-incubation of 2.5 x 10(-3) M captopril with fibrinogen also prolonged clotting time, whereas 3 x 10(-3) M captopril prolonged thrombin activity. Captopril 64-73 fibrinogen beta chain Homo sapiens 12-22 18209575-4 2008 In thrombin-fibrinogen assays, pre-incubation of 2.5 x 10(-3) M captopril with fibrinogen also prolonged clotting time, whereas 3 x 10(-3) M captopril prolonged thrombin activity. Captopril 64-73 fibrinogen beta chain Homo sapiens 79-89 17785713-3 2007 Fibrinogen levels increased with age and showed continuous, approximately linear relations with several risk markers and slightly curvilinear associations with log triglycerides, albumin, and tobacco and alcohol consumption. Triglycerides 164-177 fibrinogen beta chain Homo sapiens 0-10 17785713-3 2007 Fibrinogen levels increased with age and showed continuous, approximately linear relations with several risk markers and slightly curvilinear associations with log triglycerides, albumin, and tobacco and alcohol consumption. Alcohols 204-211 fibrinogen beta chain Homo sapiens 0-10 17898365-5 2007 RESULTS: The alpha angle, clot firmness, and fibrinogen polymerization (median [min to max]) significantly decreased in the patients receiving hydroxyethyl starch (area under the curve minus baseline (-5 [-9 to -2]), followed by gelatin solution (-3 [-8 to 0]), with the least reductions seen for Ringer lactate solution (-2 [- 4 to 1]) (colloids versus Ringer lactate P < 0.0001). Hydroxyethyl starch 143-162 fibrinogen beta chain Homo sapiens 45-55 17941280-7 2007 There was a trend to an inverse association between exhaled nitric oxide and fibrinogen (P = .049), but this was not significant after adjusting for smoking and use of corticosteroids or after further adjustment for body mass index and atopy (P = .71). Nitric Oxide 60-72 fibrinogen beta chain Homo sapiens 77-87 17890954-14 2007 Fibrinogen level decreased with UH-SK treatment for 5 days but in case of tPA we could not measure significant changes. uh-sk 32-37 fibrinogen beta chain Homo sapiens 0-10 17890955-0 2007 The role of ascorbate and histidine in fibrinogen protection against changes following exposure to a sterilizing dose of gamma-irradiation. Ascorbic Acid 12-21 fibrinogen beta chain Homo sapiens 39-49 17890955-0 2007 The role of ascorbate and histidine in fibrinogen protection against changes following exposure to a sterilizing dose of gamma-irradiation. Histidine 26-35 fibrinogen beta chain Homo sapiens 39-49 17890955-1 2007 Sodium ascorbate and histidine were employed to protect fibrinogen against modifications followed by a gamma-irradiation process that could potentially inactivate the blood-borne viruses in plasma-derived products. Ascorbic Acid 0-16 fibrinogen beta chain Homo sapiens 56-66 17890955-1 2007 Sodium ascorbate and histidine were employed to protect fibrinogen against modifications followed by a gamma-irradiation process that could potentially inactivate the blood-borne viruses in plasma-derived products. Histidine 21-30 fibrinogen beta chain Homo sapiens 56-66 17890955-7 2007 Ascorbate reduced the incorporation of carbonyls to the fibrinogen molecule (by > 50% at 50 mmol/l; P < 0.001). Ascorbic Acid 0-9 fibrinogen beta chain Homo sapiens 56-66 17890955-8 2007 Contrary to ascorbate, which alone delayed the fibrinogen polymerization rate, histidine abolished irradiation-induced inhibition of fibrinogen polymerization (by 80% at 50 mmol/l; P < 0.001). Histidine 79-88 fibrinogen beta chain Homo sapiens 133-143 17890955-9 2007 In conclusion, even though ascorbate effectively protects fibrinogen from oxidation due to its adverse effects on fibrinogen function, it may not serve as a suitable radioprotective. Ascorbic Acid 27-36 fibrinogen beta chain Homo sapiens 58-68 17890955-9 2007 In conclusion, even though ascorbate effectively protects fibrinogen from oxidation due to its adverse effects on fibrinogen function, it may not serve as a suitable radioprotective. Ascorbic Acid 27-36 fibrinogen beta chain Homo sapiens 114-124 17890955-10 2007 On the contrary, the first definite evidence is provided that radiation-sterilized fibrinogen in the presence of histidine greatly retains its clotting capability. Histidine 113-122 fibrinogen beta chain Homo sapiens 83-93 17318824-5 2007 It could be found that the PEMs-deposited TPU films with DS as the outmost layer could resist the platelet adhesion and human plasma fibrinogen (HPF) adsorption, thereby prolonging effectively the blood coagulation times. tpu 42-45 fibrinogen beta chain Homo sapiens 133-143 17318824-5 2007 It could be found that the PEMs-deposited TPU films with DS as the outmost layer could resist the platelet adhesion and human plasma fibrinogen (HPF) adsorption, thereby prolonging effectively the blood coagulation times. Dextran Sulfate 57-59 fibrinogen beta chain Homo sapiens 133-143 17885555-10 2007 In multivariable analysis, an independent association was established between fibrinogen level and PWVc-f after adjusting for age, sex, mean pressure, heart rate, height, body mass index, smoking status, and total cholesterol. Cholesterol 214-225 fibrinogen beta chain Homo sapiens 78-88 17787042-6 2007 Triglycerides were best predicted by fibrinogen, nephritis, and pleuritis (model R2 = 0.6). Triglycerides 0-13 fibrinogen beta chain Homo sapiens 37-47 17937480-5 2007 MRI parameters (T2, T1, and apparent diffusion coefficient) indicated that systems with fibrinogen and thrombin (FT and MEFT) presented a structure with many and large pores, bulk water, and higher translational motion of water. Water 222-227 fibrinogen beta chain Homo sapiens 88-98 17540543-9 2007 All obtained data showed that incorporating curcumin in rapamycin-loaded PLGA coating can significantly decrease platelet adhesion and activation, prolong APTT clotting time as well as decrease the fibrinogen adsorption. Curcumin 44-52 fibrinogen beta chain Homo sapiens 198-208 17577134-8 2007 Decreases in antithrombin III, platelet count and fibrinogen levels, prolongation of prothrombin time, and increases in the plasma fibrin degradation products were significantly suppressed by the administration of methylprednisolone. Methylprednisolone 214-232 fibrinogen beta chain Homo sapiens 50-60 17846344-9 2007 Numerous mechanisms have been proposed to explain the benefit that light-to-moderate alcohol intake has on the heart, including an increase of high-density lipoprotein cholesterol, reduction in plasma viscosity and fibrinogen concentration, increase in fibrinolysis, decrease in platelet aggregation, improvement in endothelial function, reduction of inflammation, and promotion of antioxidant effects. Alcohols 85-92 fibrinogen beta chain Homo sapiens 215-225 19568328-0 2007 Prediction of Fibrinogen Adsorption for Biodegradable Polymers: Integration of Molecular Dynamics and Surrogate Modeling. Polymers 54-62 fibrinogen beta chain Homo sapiens 14-24 19568328-1 2007 This work is a part of a series of publications devoted to the development of surrogate (semi-empirical) models for the prediction of fibrinogen adsorption onto polymer surfaces. Polymers 161-168 fibrinogen beta chain Homo sapiens 134-144 19568328-10 2007 The significance of the newly developed 3D model is that it allows high accuracy prediction of fibrinogen adsorption without the need for experimentally derived descriptors and it has better predictive quality than the original 2D surrogate model due to utilization of realistic polymer representations. Polymers 279-286 fibrinogen beta chain Homo sapiens 95-105 17705531-0 2007 Fibrinogen-catecholamine interaction as observed by NMR and Fourier transform infrared spectroscopy. Catecholamines 11-24 fibrinogen beta chain Homo sapiens 0-10 17705531-1 2007 In this work, the interactions between the main catecholamines-epinephrine and norepinephrine-and fibrinogen were investigated by NMR and Fourier transform infrared spectroscopies. Catecholamines 48-62 fibrinogen beta chain Homo sapiens 98-108 17705531-1 2007 In this work, the interactions between the main catecholamines-epinephrine and norepinephrine-and fibrinogen were investigated by NMR and Fourier transform infrared spectroscopies. Epinephrine 63-74 fibrinogen beta chain Homo sapiens 98-108 17715960-0 2007 PM-IRRAS investigation of the interaction of serum albumin and fibrinogen with a biomedical-grade stainless steel 316LVM surface. Stainless Steel 98-113 fibrinogen beta chain Homo sapiens 63-73 17715960-1 2007 Polarization modulation infrared reflection absorption spectroscopy (PM-IRRAS) was applied to investigate the interaction of bovine serum albumin (BSA) and fibrinogen with a biomedical-grade 316LVM stainless steel surface, in terms of the adsorption thermodynamics and adsorption-induced secondary structure changes of the proteins. Stainless Steel 198-213 fibrinogen beta chain Homo sapiens 156-166 18457045-1 2007 Oxidatively-modified fibrinogen induces platelet aggregation and potentiates ADP-induced platelet aggregation and production of active oxygen forms in zymosan-stimulated leukocytes. Adenosine Diphosphate 77-80 fibrinogen beta chain Homo sapiens 21-31 18457045-1 2007 Oxidatively-modified fibrinogen induces platelet aggregation and potentiates ADP-induced platelet aggregation and production of active oxygen forms in zymosan-stimulated leukocytes. Oxygen 135-141 fibrinogen beta chain Homo sapiens 21-31 18457045-1 2007 Oxidatively-modified fibrinogen induces platelet aggregation and potentiates ADP-induced platelet aggregation and production of active oxygen forms in zymosan-stimulated leukocytes. Zymosan 151-158 fibrinogen beta chain Homo sapiens 21-31 18457045-4 2007 Oxidized fibrinogen modified blood clotting parameters and ADP-, ristocetin-, and collagen-induced platelet aggregation in whole blood. Adenosine Diphosphate 59-62 fibrinogen beta chain Homo sapiens 9-19 18457045-4 2007 Oxidized fibrinogen modified blood clotting parameters and ADP-, ristocetin-, and collagen-induced platelet aggregation in whole blood. Ristocetin 65-75 fibrinogen beta chain Homo sapiens 9-19 18457045-6 2007 Platelet aggregation was activated in response to ADP, but not to ristocetin and collagen, the degree of activation increased in direct proportion to the degree of fibrinogen oxidation. Adenosine Diphosphate 50-53 fibrinogen beta chain Homo sapiens 164-174 17559410-6 2007 For C. lipolytica, a approximately 60-kDa gelatin-degrading serine proteolytic activity was found in the TSB supernantant as well as a metallopeptidase activity capable of hydrolysing human albumin, IgG and human fibrinogen. Serine 60-66 fibrinogen beta chain Homo sapiens 213-223 18035190-16 2007 With regard to CVD biomarkers, there were potentially deleterious changes compared with baseline in the GLY+PBO group for CRP (+29.4%; P = 0.042), PAI-1 activity (+27.0%; P = 0.006), fibrinogen (+15.7%; P = 0.007), and sVCAM (+7.0%; P = 0.035), whereas there were no significant increases in these factors in the GLY+RSG group. gly+pbo 104-111 fibrinogen beta chain Homo sapiens 183-193 17236214-1 2007 The ability of tetraethylene glycol dimethyl ether (tetraglyme) plasma deposited coatings exhibiting ultralow fibrinogen adsorption to reduce blood activation was studied with six in vitro methods, namely fibrinogen and von Willebrand"s factor adsorption, total protein adsorption, clotting time in recalcified plasma, platelet adhesion and procoagulant activity, and whole blood thrombosis in a disturbed flow catheter model. tetraglyme 15-50 fibrinogen beta chain Homo sapiens 110-120 17656657-6 2007 Before surgery, clopidogrel produced a significant reduction in the platelet response to ADP; for example, with 10(-6)M ADP, 77.32+/-2.3% bound fibrinogen in placebo group compared with 67.16+/-3.1% after clopidogrel (P=0.01). Clopidogrel 16-27 fibrinogen beta chain Homo sapiens 144-154 17656657-6 2007 Before surgery, clopidogrel produced a significant reduction in the platelet response to ADP; for example, with 10(-6)M ADP, 77.32+/-2.3% bound fibrinogen in placebo group compared with 67.16+/-3.1% after clopidogrel (P=0.01). Adenosine Diphosphate 120-123 fibrinogen beta chain Homo sapiens 144-154 17656657-7 2007 This was accentuated after surgery when the percentage of platelets binding fibrinogen in response to ADP was 76.53+/-2.2% in patients given placebo and 62.84+/-3.3% in the clopidogrel group (P=0.002). Adenosine Diphosphate 102-105 fibrinogen beta chain Homo sapiens 76-86 17656657-7 2007 This was accentuated after surgery when the percentage of platelets binding fibrinogen in response to ADP was 76.53+/-2.2% in patients given placebo and 62.84+/-3.3% in the clopidogrel group (P=0.002). Clopidogrel 173-184 fibrinogen beta chain Homo sapiens 76-86 20641803-5 2004 A tripeptide sequence consisting of Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3. tripeptide K-26 2-12 fibrinogen beta chain Homo sapiens 149-159 20641803-5 2004 A tripeptide sequence consisting of Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3. Arginine 36-39 fibrinogen beta chain Homo sapiens 149-159 20641803-5 2004 A tripeptide sequence consisting of Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3. glycylaspartic acid 40-47 fibrinogen beta chain Homo sapiens 149-159 17663740-4 2007 Addition of this peptide, or peptide gamma365-380 (NH(2)-NGIIWATKTREWYSMK-COOH) to a mixture of fibrinogen and thrombin resulted a shorter clotting time, higher clot turbidity, lower clot elastic modulus, a higher degree of D-trimer and D-tetramer formation, and impaired plasmin proteolysis of the clot. Carbonic Acid 74-78 fibrinogen beta chain Homo sapiens 96-106 18000621-0 2007 Fibrinogen Tolaga Bay: a novel gammaAla341Val mutation causing hypofibrinogenaemia. gammaala341val 31-45 fibrinogen beta chain Homo sapiens 0-10 17442062-5 2007 Clasmatodendritic astroglia, immunoreactive for the serum protein fibrinogen, were present in 67% of PVL examined and 42% of DSCL. dscl 125-129 fibrinogen beta chain Homo sapiens 66-76 17585853-0 2007 Antibodies to citrullinated human fibrinogen synthetic peptides in diagnosing rheumatoid arthritis. Peptides 55-63 fibrinogen beta chain Homo sapiens 34-44 17640335-5 2007 The biological potency of heparin was determined photometrically by the chromogenic substrate Chromozym TH and fibrinogen adsorption to the modified surfaces was researched using the QCM-D (Quartz Crystal Microbalance with Dissipation Monitoring) technique. Heparin 26-33 fibrinogen beta chain Homo sapiens 111-121 17640335-11 2007 QCM-D measurements showed a lower viscosity for adsorbed fibrinogen films on heparinised surfaces by means of Triamino-APMS. Tromethamine 110-118 fibrinogen beta chain Homo sapiens 57-67 17509522-6 2007 The resultant functions indicated that both specific and nonspecific associations of antibody molecules with fibrinogen occurred through a variety of molecular interactions, including hydrophophic, ionic and hydrogen bonding mechanisms. Hydrogen 208-216 fibrinogen beta chain Homo sapiens 109-119 18650989-1 2007 OBJECTIVE: To find out whether the addition of fenofibrate to statin monotherapy produced any synergistic or additive beneficial effects in reducing risk factors, especially plasma fibrinogen, in patients with acute coronary syndrome (ACS) requiring percutaneous coronary interventions. Fenofibrate 47-58 fibrinogen beta chain Homo sapiens 181-191 18650989-9 2007 Statin monotherapy as well as its combination with fenofibrate produced a significant decrease in the fibrinogen levels. Fenofibrate 51-62 fibrinogen beta chain Homo sapiens 102-112 18650989-11 2007 Statins decreased plasma fibrinogen significantly, contrary to results from various reports, and the addition of fenofibrate further enhanced this reduction of the novel risk factor fibrinogen. Fenofibrate 113-124 fibrinogen beta chain Homo sapiens 182-192 17236214-1 2007 The ability of tetraethylene glycol dimethyl ether (tetraglyme) plasma deposited coatings exhibiting ultralow fibrinogen adsorption to reduce blood activation was studied with six in vitro methods, namely fibrinogen and von Willebrand"s factor adsorption, total protein adsorption, clotting time in recalcified plasma, platelet adhesion and procoagulant activity, and whole blood thrombosis in a disturbed flow catheter model. tetraglyme 52-62 fibrinogen beta chain Homo sapiens 110-120 17543636-0 2007 Elevated plasma fibrinogen level predicts suboptimal response to therapy with both single- and double-bolus eptifibatide during percutaneous coronary intervention. Eptifibatide 108-120 fibrinogen beta chain Homo sapiens 16-26 17531931-3 2007 METHODS: We tested the hypothesis that a more modern antihypertensive drug regimen (ie, amlodipine +/- perindopril) would have a more beneficial effect on hemorheological markers (white blood-cell count [WCC], plasma viscosity [PV], hematocrit [HCT], and fibrinogen)--and on plasma von Willebrand factor (vWf, an index of endothelial damage and dysfunction) and soluble P-selectin (sP-sel, an index of platelet activation), compared with an older antihypertensive drug regimen (ie, atenolol +/- bendroflumethiazide). Amlodipine 88-98 fibrinogen beta chain Homo sapiens 255-265 17531931-3 2007 METHODS: We tested the hypothesis that a more modern antihypertensive drug regimen (ie, amlodipine +/- perindopril) would have a more beneficial effect on hemorheological markers (white blood-cell count [WCC], plasma viscosity [PV], hematocrit [HCT], and fibrinogen)--and on plasma von Willebrand factor (vWf, an index of endothelial damage and dysfunction) and soluble P-selectin (sP-sel, an index of platelet activation), compared with an older antihypertensive drug regimen (ie, atenolol +/- bendroflumethiazide). Perindopril 103-114 fibrinogen beta chain Homo sapiens 255-265 17492711-1 2007 The adsorption of BSA and fibrinogen onto plasma-polymerized di-(ethylene glycol) vinyl ether, allylamine, and maleic anhydride films were investigated in detail by surface plasmon resonance spectroscopy (SPR). diethylene glycol vinyl ether 61-93 fibrinogen beta chain Homo sapiens 26-36 17492711-1 2007 The adsorption of BSA and fibrinogen onto plasma-polymerized di-(ethylene glycol) vinyl ether, allylamine, and maleic anhydride films were investigated in detail by surface plasmon resonance spectroscopy (SPR). Allylamine 95-105 fibrinogen beta chain Homo sapiens 26-36 17492711-1 2007 The adsorption of BSA and fibrinogen onto plasma-polymerized di-(ethylene glycol) vinyl ether, allylamine, and maleic anhydride films were investigated in detail by surface plasmon resonance spectroscopy (SPR). Maleic Anhydrides 111-127 fibrinogen beta chain Homo sapiens 26-36 17539777-2 2007 GPVI is co-associated with Fc receptor gamma-chain (FcRgamma), which contains a cytoplasmic immunoreceptor tyrosine-based activation motif domain, involved in activation of Syk, and a signalling cascade leading to (i) activation of alpha(IIb)beta(3), which binds VWF and fibrinogen and mediates platelet aggregation, and (ii) metalloproteinase-mediated shedding of the GPVI ectodomain (blocked by Syk inhibitors), a key mechanism for regulating GPVI surface expression. Tyrosine 107-115 fibrinogen beta chain Homo sapiens 271-281 17596649-0 2007 Homocysteine and fibrinogen changes with L-thyroxine in subclinical hypothyroid patients. Thyroxine 41-52 fibrinogen beta chain Homo sapiens 17-27 17658313-0 2007 Study of fibrinogen adsorption on hydroxyapatite and TiO2 surfaces by electrochemical piezoelectric quartz crystal impedance and FTIR-ATR spectroscopy. Durapatite 34-48 fibrinogen beta chain Homo sapiens 9-19 17658313-0 2007 Study of fibrinogen adsorption on hydroxyapatite and TiO2 surfaces by electrochemical piezoelectric quartz crystal impedance and FTIR-ATR spectroscopy. titanium dioxide 53-57 fibrinogen beta chain Homo sapiens 9-19 17658313-4 2007 The results suggested that two consecutive steps occurred during the adsorption of fibrinogen onto TiO2 and hydroxyapatite (HAP) surface. titanium dioxide 99-103 fibrinogen beta chain Homo sapiens 83-93 17658313-4 2007 The results suggested that two consecutive steps occurred during the adsorption of fibrinogen onto TiO2 and hydroxyapatite (HAP) surface. Durapatite 108-122 fibrinogen beta chain Homo sapiens 83-93 17337166-0 2007 pH and ionic strength effect on single fibrinogen molecule adsorption on mica studied with AFM. mica 73-77 fibrinogen beta chain Homo sapiens 39-49 17337166-2 2007 We have used atomic force microscopy to image, in phosphate buffer, single fibrinogen molecules adsorbed on mica and compare the surface coverage at variable pH (7.4, 5.8, 3.5) or ionic strength (15, 150, 500 mM) conditions. mica 108-112 fibrinogen beta chain Homo sapiens 75-85 17408294-3 2007 FB mixtures with water (0.075 wt %) were quite unstable and biphasic. Water 17-22 fibrinogen beta chain Homo sapiens 0-2 17408294-5 2007 The addition of DPPC vesicles into these unstable FB dispersions reversed FB aggregation and precipitation and produced stable translucent microdispersions. 1,2-Dipalmitoylphosphatidylcholine 16-20 fibrinogen beta chain Homo sapiens 50-52 17408294-10 2007 Adding salt to an aggregated FB dispersion in water reversed the aggregation. Salts 7-11 fibrinogen beta chain Homo sapiens 29-31 17469143-10 2007 CONCLUSION: Our findings suggest that risk of GMT in lupus nephritis is attributable, at least in part, to an epistatic effect of PAI-1 and FGB genes, likely via an interaction with environmental/clinical factors, such as aCL. GlcNAc-Mal 46-49 fibrinogen beta chain Homo sapiens 140-143 17408294-11 2007 FB aggregated and redissolved in the presence of the citrate and after the citrate was removed. Citric Acid 53-60 fibrinogen beta chain Homo sapiens 0-2 17408294-11 2007 FB aggregated and redissolved in the presence of the citrate and after the citrate was removed. Citric Acid 75-82 fibrinogen beta chain Homo sapiens 0-2 17321765-8 2007 In the presence of fibrinogen, LPA (10 microM) induced ATP-secretion from dense granules and aggregation, and cofilin was rapidly dephosphorylated and then rephosphorylated in a Rho-kinase/LIMK-1-dependent manner. lysophosphatidic acid 31-34 fibrinogen beta chain Homo sapiens 19-29 17321765-8 2007 In the presence of fibrinogen, LPA (10 microM) induced ATP-secretion from dense granules and aggregation, and cofilin was rapidly dephosphorylated and then rephosphorylated in a Rho-kinase/LIMK-1-dependent manner. Adenosine Triphosphate 55-58 fibrinogen beta chain Homo sapiens 19-29 17456992-8 2007 Furthermore, patients with higher dopamine levels had lower left ventricular (LV) ejection fraction and higher levels of brain natriuretic peptide, C-reactive protein, and fibrinogen than those with lower dopamine levels. Dopamine 34-42 fibrinogen beta chain Homo sapiens 172-182 17940987-7 2007 Fibrinogen concentrations significantly decreased in DHEA group from 4.5 +/- 0.3 g/l to 3.83 +/- 0.2 g/l (p < 0.05 vs. placebo). Dehydroepiandrosterone 53-57 fibrinogen beta chain Homo sapiens 0-10 17940987-10 2007 CONCLUSIONS: DHEA therapy in dose of 150 mg daily during 40 days in men with DHEAS levels < 2000 mg/l and angiographically verified coronary heart disease (CHD) was connected with significant decreasing of fibrinogen concentration and increasing of estradiol levels, and did not influence on plasminogen activator inhibitor-1 (PAI-1) and tissue plasminogen activator (tPA) plasma concentrations. Dehydroepiandrosterone 13-17 fibrinogen beta chain Homo sapiens 209-219 17940987-1 2007 INTRODUCTION: The aim of this study was to analyze the influence of DHEA therapy on fibrinogen, plasminogen activator inhibitor-1 (PAI-1) and tissue plasminogen activator (tPA) plasma concentrations in men with decreased serum DHEA-S levels and angiographically verified coronary heart disease (CHD). Dehydroepiandrosterone 68-72 fibrinogen beta chain Homo sapiens 84-94 17133446-0 2007 Quantification of fibrinogen adsorption onto 316L stainless steel. Stainless Steel 50-65 fibrinogen beta chain Homo sapiens 18-28 17268270-1 2007 STUDY DESIGN: Prospective evaluation of fibrinogen levels before surgery and after surgery in patients with idiopathic scoliosis undergoing posterior spinal fusion (PSF) and segmental spinal instrumentation (SSI) who received Amicar to decrease perioperative blood loss. Aminocaproic Acid 226-232 fibrinogen beta chain Homo sapiens 40-50 17133446-1 2007 Adsorption of the plasma protein fibrinogen (Fb) onto 316L stainless steel (316L SS) was observed and quantified using both in situ and ex situ atomic force microscopy techniques. Stainless Steel 59-74 fibrinogen beta chain Homo sapiens 33-43 17133446-1 2007 Adsorption of the plasma protein fibrinogen (Fb) onto 316L stainless steel (316L SS) was observed and quantified using both in situ and ex situ atomic force microscopy techniques. Stainless Steel 59-74 fibrinogen beta chain Homo sapiens 45-47 17445537-9 2007 Fibrinogen was independently associated with female sex, body mass index, renal dysfunction, low levels of high-density lipoprotein cholesterol and diabetes, whereas the independent predictors for factor VIIc were Torres Strait Islander ethnicity, female sex, body mass index, renal dysfunction, and total cholesterol. Cholesterol 132-143 fibrinogen beta chain Homo sapiens 0-10 17039513-5 2007 In this study, the ability of a novel platelet GPIIb/IIIa antagonist, a free acid form of roxifiban (XV459), to block platelet activation/aggregation in response to highly characterized heparin-PF4 antibody-positive plasma/heparin was examined using light transmittance aggregometry, serotonin release, and (125)I-fibrinogen binding assays to human platelets. roxifiban 90-99 fibrinogen beta chain Homo sapiens 314-324 17039513-5 2007 In this study, the ability of a novel platelet GPIIb/IIIa antagonist, a free acid form of roxifiban (XV459), to block platelet activation/aggregation in response to highly characterized heparin-PF4 antibody-positive plasma/heparin was examined using light transmittance aggregometry, serotonin release, and (125)I-fibrinogen binding assays to human platelets. XV 459 101-106 fibrinogen beta chain Homo sapiens 314-324 17039513-8 2007 Concentration-dependent profiles of XV459 on the mean percent inhibition of (125)I-fibrinogen binding in the presence of HIT antibodies and TEAC were achieved ( approximately 50% inhibition at 10 nM XV459). XV 459 36-41 fibrinogen beta chain Homo sapiens 83-93 17039513-8 2007 Concentration-dependent profiles of XV459 on the mean percent inhibition of (125)I-fibrinogen binding in the presence of HIT antibodies and TEAC were achieved ( approximately 50% inhibition at 10 nM XV459). XV 459 199-204 fibrinogen beta chain Homo sapiens 83-93 16697386-7 2007 Additionally, interactions between FGB and with environmental factors (alcohol and smoking in men, and BMI in women) were found. Alcohols 71-78 fibrinogen beta chain Homo sapiens 35-38 17400977-6 2007 Overall, FBG formation was significantly increased in the AMIO group (P = 0.048). Amiodarone 58-62 fibrinogen beta chain Homo sapiens 9-12 17291015-5 2007 Our study addressed the question regarding to which extent systematic variations in polymer structure can be used to optimize X-ray visibility and provide tunable degradation rates while generating protein-repellant surface properties that minimize fibrinogen adsorption. Polymers 84-91 fibrinogen beta chain Homo sapiens 249-259 17291015-7 2007 While we did not find an overall correlation between surface air-water contact angle measurements and fibrinogen adsorption (R2 = 0.08), our data demonstrate that gradually increasing the poly(ethylene glycol) content within a subgroup of polymers having the same polymer backbone will lead to decreased fibrinogen adsorption. Polyethylene Glycols 188-209 fibrinogen beta chain Homo sapiens 304-314 17291015-8 2007 Within this subgroup of polymers, there was a strong correlation between decreasing air-water contact angles and decreasing fibrinogen adsorption (R2 = 0.95). Polymers 24-32 fibrinogen beta chain Homo sapiens 124-134 17291015-8 2007 Within this subgroup of polymers, there was a strong correlation between decreasing air-water contact angles and decreasing fibrinogen adsorption (R2 = 0.95). Water 88-93 fibrinogen beta chain Homo sapiens 124-134 17291015-9 2007 We conclude that it is possible to minimize fibrinogen adsorption to tyrosine-derived polycarbonates while optimizing X-ray visibility and degradation rates. tyrosine-derived polycarbonates 69-100 fibrinogen beta chain Homo sapiens 44-54 17291015-10 2007 Some of the tyrosine-derived polycarbonates were identified as useful materials for the design of blood-contacting implants on the basis of their substantially lower levels of fibrinogen adsorption relative to the commonly used controls. Tyrosine 12-20 fibrinogen beta chain Homo sapiens 176-186 17291015-10 2007 Some of the tyrosine-derived polycarbonates were identified as useful materials for the design of blood-contacting implants on the basis of their substantially lower levels of fibrinogen adsorption relative to the commonly used controls. derived polycarbonates 21-43 fibrinogen beta chain Homo sapiens 176-186 17120211-0 2007 Inflammatory response to titanium surfaces with fibrinogen and catalase coatings: an in vitro study. Titanium 25-33 fibrinogen beta chain Homo sapiens 48-58 17305652-11 2007 RSG treatment led to significant reductions of HOMA-IR, fasting plasma glucose, HbA1c, PAI-1 activity, fibrinogen, C-reactive protein and matrix metalloproteinase-9. Rosiglitazone 0-3 fibrinogen beta chain Homo sapiens 103-113 17296856-4 2007 Compared with subjects with no detectable cotinine, those with detectable but low-level cotinine (range, 0.05 to 0.215 ng/mL) had significantly higher levels of both fibrinogen (adjusted mean difference, 8.9 mg/dL; 95% CI, 0.9 to 17.0; P=0.03) and homocysteine (0.8 micromol/L; 95% CI, 0.4 to 1.1; P<0.001) but not C-reactive protein or white blood cell count. Cotinine 88-96 fibrinogen beta chain Homo sapiens 166-176 17174535-4 2007 It could be found that the PTAT-PEMs membranes with DS as the outmost layer could resist the platelet adhesion and human plasma fibrinogen (HPF) adsorption, thereby prolonging effectively the blood coagulation times. Dextran Sulfate 52-54 fibrinogen beta chain Homo sapiens 128-138 17602156-1 2007 Sulodexide, a standardized extractive glycosaminoglycan containing 80% "fast moving" heparin and 20% dermatan sulfate, decreased plasma D-dimer, a marker of intravascular coagulation, and fibrinogen levels in chronic peritoneal dialysis patients. glucuronyl glucosamine glycan sulfate 0-10 fibrinogen beta chain Homo sapiens 188-198 17479194-6 2007 HMW-fibrinogen was separated from unfractioned fibrinogen by ammonium sulphate precipitation. Ammonium Sulfate 61-78 fibrinogen beta chain Homo sapiens 4-14 17522372-5 2007 Micronized fenofibrate also significantly decreased fibrinogen (421 +/- 152 vs 344 +/- 81 mg/dl, p <0.001), hs-CRP (3.3 +/- 3.3 vs 2.1 +/- 1.8 mg/L, p <0.01), and ESR (19.1 +/- 24.8 vs 9.7 +/- 8.7 mm/hr, p <0.01), but did not change proinsulin levels. Fenofibrate 11-22 fibrinogen beta chain Homo sapiens 52-62 17522372-8 2007 In conclusion, after 12 wk, micronized fenofibrate therapy significantly decreased 3 inflammatory markers (hs-CRP, ESR, and fibrinogen) and improved the lipid profile by decreasing serum triglyceride, cholesterol, and non-HDL-cholesterol levels and increasing HDL-cholesterol; however, it did not change serum proinsulin level, a pancreatic stress marker. Fenofibrate 39-50 fibrinogen beta chain Homo sapiens 124-134 17413765-6 2007 Ascorbate (25 mmol/l) raised the level of functional fibrinogen in irradiated plasma (to 50%; P=0.0245) and slightly accelerated its polymerization. Ascorbic Acid 0-9 fibrinogen beta chain Homo sapiens 53-63 17413765-7 2007 The small protective effect of ascorbate might be due to inhibition of the radiation-induced fibrinogen oxidation and/or fragmentation but addition of other antioxidants/stabilizers would be crucial when a high irradiation dose, an effective treatment for inactivation of the most resistant viruses, is applied. Ascorbic Acid 31-40 fibrinogen beta chain Homo sapiens 93-103 17456623-11 2007 Final arginine concentrations of at least 250 mM completely inhibit turbidity increase, when arginine acts in the first 4 minutes (RT) of the thrombin/ fibrinogen interaction. Arginine 6-14 fibrinogen beta chain Homo sapiens 152-162 17456623-11 2007 Final arginine concentrations of at least 250 mM completely inhibit turbidity increase, when arginine acts in the first 4 minutes (RT) of the thrombin/ fibrinogen interaction. Arginine 93-101 fibrinogen beta chain Homo sapiens 152-162 17456623-12 2007 A final arginine concentration of 477 mM added at the 12-minute or 30-minute thrombin/ fibrinogen reaction time point decreases the resulting turbidity by 50% after an additional 30 minutes at RT. Arginine 8-16 fibrinogen beta chain Homo sapiens 87-97 17120208-0 2007 Fibrinogen adsorption and platelet lysis characterization of fluorinated surface-modified polyetherurethanes. polyetherurethane 90-108 fibrinogen beta chain Homo sapiens 0-10 17275949-0 2007 Integrin alphavbeta6 mediates HT29-D4 cell adhesion to MMP-processed fibrinogen in the presence of Mn2+. Manganese(2+) 99-103 fibrinogen beta chain Homo sapiens 69-79 17275949-1 2007 Mn(2+) was found to induce adhesion of HT29-D4 adenoma carcinoma cells to fibrinogen (Fb). Manganese(2+) 0-6 fibrinogen beta chain Homo sapiens 74-84 17275949-1 2007 Mn(2+) was found to induce adhesion of HT29-D4 adenoma carcinoma cells to fibrinogen (Fb). Manganese(2+) 0-6 fibrinogen beta chain Homo sapiens 86-88 17275949-5 2007 As a MAPK inhibitor strongly reduced the Mn(2+)-induced cell adhesion to Fb, it is suggested that a link between MAPK activation and cell adhesion to Fb exists. Manganese(2+) 41-47 fibrinogen beta chain Homo sapiens 73-75 18360620-7 2007 Moreover, valsartan administration at bedtime as opposed to upon wakening results in improved diurnal/nocturnal ratio, a significant increase in the percentage of patients with controlled BP after treatment, and significant reductions in urinary albumin excretion and plasma fibrinogen. Valsartan 10-19 fibrinogen beta chain Homo sapiens 275-285 17291077-1 2007 Platelet adhesion and activation induced by fibrinogen (Fbg) coating on polysaccharide layers of hyaluronic acid (Hyal) and its sulfated derivative (HyalS) were analyzed. Polysaccharides 72-86 fibrinogen beta chain Homo sapiens 44-54 17291077-1 2007 Platelet adhesion and activation induced by fibrinogen (Fbg) coating on polysaccharide layers of hyaluronic acid (Hyal) and its sulfated derivative (HyalS) were analyzed. Polysaccharides 72-86 fibrinogen beta chain Homo sapiens 56-59 17291077-1 2007 Platelet adhesion and activation induced by fibrinogen (Fbg) coating on polysaccharide layers of hyaluronic acid (Hyal) and its sulfated derivative (HyalS) were analyzed. Hyaluronic Acid 97-112 fibrinogen beta chain Homo sapiens 44-54 17291077-1 2007 Platelet adhesion and activation induced by fibrinogen (Fbg) coating on polysaccharide layers of hyaluronic acid (Hyal) and its sulfated derivative (HyalS) were analyzed. Hyaluronic Acid 97-112 fibrinogen beta chain Homo sapiens 56-59 17291077-3 2007 The Fbg coating was achieved by two different routes: the immobilization of Fbg by means of covalent bond to the polysaccharide layers and the mere adsorption of Fbg to Hyal and HyalS surfaces. Polysaccharides 113-127 fibrinogen beta chain Homo sapiens 4-7 17291077-3 2007 The Fbg coating was achieved by two different routes: the immobilization of Fbg by means of covalent bond to the polysaccharide layers and the mere adsorption of Fbg to Hyal and HyalS surfaces. Polysaccharides 113-127 fibrinogen beta chain Homo sapiens 76-79 17291077-3 2007 The Fbg coating was achieved by two different routes: the immobilization of Fbg by means of covalent bond to the polysaccharide layers and the mere adsorption of Fbg to Hyal and HyalS surfaces. Polysaccharides 113-127 fibrinogen beta chain Homo sapiens 76-79 17268270-3 2007 SUMMARY OF BACKGROUND DATA: Our previous randomized, double-blind (Amicar and control) study demonstrated a rise in fibrinogen levels on the first postoperative day in the Amicar group, but not in the control group. Aminocaproic Acid 67-73 fibrinogen beta chain Homo sapiens 116-126 17268270-7 2007 METHODS: We analyzed fibrinogen levels before surgery and on all postoperative days (4 or 5 days) until discharge in 51 consecutive patients, including our 21 previously reported patients, who received Amicar and underwent a PSF and SSI. Aminocaproic Acid 202-208 fibrinogen beta chain Homo sapiens 21-31 17164498-1 2007 Vancomycin precipitates fibrinogen. Vancomycin 0-10 fibrinogen beta chain Homo sapiens 24-34 17164498-2 2007 The turbidity induced by this vancomycin-fibrinogen interaction is used to establish a simple standardized antigenic assay for plasmatic fibrinogen, the FIATA. Vancomycin 30-40 fibrinogen beta chain Homo sapiens 41-51 17164498-2 2007 The turbidity induced by this vancomycin-fibrinogen interaction is used to establish a simple standardized antigenic assay for plasmatic fibrinogen, the FIATA. Vancomycin 30-40 fibrinogen beta chain Homo sapiens 137-147 17164498-3 2007 1 mM vancomycin or 2 mM chloramine-T inactivates 50% of fibrinogen in human plasma. Vancomycin 5-15 fibrinogen beta chain Homo sapiens 56-66 17164498-3 2007 1 mM vancomycin or 2 mM chloramine-T inactivates 50% of fibrinogen in human plasma. chloramine-T 24-36 fibrinogen beta chain Homo sapiens 56-66 17164498-13 2007 The vancomycin/fibrinogen interaction (binding of about 16 molecules of vancomycin/molecule of fibrinogen) can be used to purify fibrinogen out of plasma. Vancomycin 4-14 fibrinogen beta chain Homo sapiens 15-25 17164498-13 2007 The vancomycin/fibrinogen interaction (binding of about 16 molecules of vancomycin/molecule of fibrinogen) can be used to purify fibrinogen out of plasma. Vancomycin 4-14 fibrinogen beta chain Homo sapiens 95-105 17164498-13 2007 The vancomycin/fibrinogen interaction (binding of about 16 molecules of vancomycin/molecule of fibrinogen) can be used to purify fibrinogen out of plasma. Vancomycin 4-14 fibrinogen beta chain Homo sapiens 95-105 17164498-13 2007 The vancomycin/fibrinogen interaction (binding of about 16 molecules of vancomycin/molecule of fibrinogen) can be used to purify fibrinogen out of plasma. Vancomycin 72-82 fibrinogen beta chain Homo sapiens 15-25 17164498-13 2007 The vancomycin/fibrinogen interaction (binding of about 16 molecules of vancomycin/molecule of fibrinogen) can be used to purify fibrinogen out of plasma. Vancomycin 72-82 fibrinogen beta chain Homo sapiens 95-105 17164498-13 2007 The vancomycin/fibrinogen interaction (binding of about 16 molecules of vancomycin/molecule of fibrinogen) can be used to purify fibrinogen out of plasma. Vancomycin 72-82 fibrinogen beta chain Homo sapiens 95-105 17164498-14 2007 Vancomycin also clouds dysfunctional fibrinogen (fibrinogen in presence of EDTA or chloramine-T)or soluble fibrin. Vancomycin 0-10 fibrinogen beta chain Homo sapiens 37-47 17164498-14 2007 Vancomycin also clouds dysfunctional fibrinogen (fibrinogen in presence of EDTA or chloramine-T)or soluble fibrin. Vancomycin 0-10 fibrinogen beta chain Homo sapiens 49-59 17164498-14 2007 Vancomycin also clouds dysfunctional fibrinogen (fibrinogen in presence of EDTA or chloramine-T)or soluble fibrin. Edetic Acid 75-79 fibrinogen beta chain Homo sapiens 49-59 17164498-14 2007 Vancomycin also clouds dysfunctional fibrinogen (fibrinogen in presence of EDTA or chloramine-T)or soluble fibrin. chloramine-T 83-95 fibrinogen beta chain Homo sapiens 49-59 17164498-15 2007 Vancomycin-reacted fibrinogen stimulates tissue type plasminogen activator (t-PA) up to about 20-fold. Vancomycin 0-10 fibrinogen beta chain Homo sapiens 19-29 17164498-19 2007 Fibrinogen precipitation by vancomycin within the blood vessel might explain why vancomycin has to be infused slowly (< 10 mg/min) to prevent nephrotoxicity. Vancomycin 28-38 fibrinogen beta chain Homo sapiens 0-10 17164498-19 2007 Fibrinogen precipitation by vancomycin within the blood vessel might explain why vancomycin has to be infused slowly (< 10 mg/min) to prevent nephrotoxicity. Vancomycin 81-91 fibrinogen beta chain Homo sapiens 0-10 17937605-4 2007 Protein targets for the modification by Hcy-thiolactone in human blood include fibrinogen, low-density lipoprotein, and high-density lipoprotein. homocysteine thiolactone 40-55 fibrinogen beta chain Homo sapiens 79-89 17209672-3 2007 Fenofibrate also has nonlipid (i.e. pleiotropic) effects (e.g. it reduces fibrinogen, C-reactive protein and uric acid levels and improves flow-mediated dilatation). Fenofibrate 0-11 fibrinogen beta chain Homo sapiens 74-84 17455220-9 2007 DSA achieved a significantly higher reduction rate of fibrinogen. dsa 0-3 fibrinogen beta chain Homo sapiens 54-64 17885889-3 2007 The depletion of SER in clotting is associated with fibrinogen, as shown by crossed-affinity immunoelectrophoresis with antisera to plasma proteins. Serine 17-20 fibrinogen beta chain Homo sapiens 52-62 17885889-4 2007 The SER-associated fibrinogen was purified and analysed by the SDS-polyacrylamide gel electrophoresis and immunoblotting. Serine 4-7 fibrinogen beta chain Homo sapiens 19-29 17885889-4 2007 The SER-associated fibrinogen was purified and analysed by the SDS-polyacrylamide gel electrophoresis and immunoblotting. Sodium Dodecyl Sulfate 63-66 fibrinogen beta chain Homo sapiens 19-29 17885889-4 2007 The SER-associated fibrinogen was purified and analysed by the SDS-polyacrylamide gel electrophoresis and immunoblotting. polyacrylamide 67-81 fibrinogen beta chain Homo sapiens 19-29 17015275-3 2006 Thermal treatment of pooled samples of human citrate-plasma or EDTA-plasma at 50 degrees C resulted in a rapid and parallel loss of fibrinogen concentration and AOPP reactivity. Citric Acid 45-52 fibrinogen beta chain Homo sapiens 132-142 17454848-5 2007 RESULTS: Changes by day 4: The ESs and significance levels were: CRP 1.7, p<0.005; lymphocyte count 1.4, p<0.005; fibrinogen 0.9, p<0.005; ESR 0.7, p<0.005; and HAQ 0.6, p<0.01. ESS 31-34 fibrinogen beta chain Homo sapiens 120-130 16500696-7 2007 The logistic regression analysis confirmed that both high fibrinogen (> or =340 mg/dl) and cholesterol (> or =267 mg/dl) levels significantly and independently influence the TSA concentration. trichostatin A 180-183 fibrinogen beta chain Homo sapiens 58-68 17156827-8 2007 After control of blood glucose, fibrinogen glycation was reduced significantly in the subjects with diabetes (7.84 to 5.24 mol glucose/mol fibrinogen; p<0.0002). Blood Glucose 17-30 fibrinogen beta chain Homo sapiens 32-42 17156827-8 2007 After control of blood glucose, fibrinogen glycation was reduced significantly in the subjects with diabetes (7.84 to 5.24 mol glucose/mol fibrinogen; p<0.0002). Glucose 23-30 fibrinogen beta chain Homo sapiens 32-42 17156827-11 2007 Fibrinogen glycation correlated best with the average fasting capillary glucose of the preceding 5-8 days (r=0.54, p=0.014). Glucose 72-79 fibrinogen beta chain Homo sapiens 0-10 17156827-12 2007 CONCLUSION: We conclude that glucose control under out-patient conditions decreases fibrinogen glycation in subjects with Type 2 diabetes and that glycated fibrinogen compares well with HbA1c in its relation to glycaemic control. Glucose 29-36 fibrinogen beta chain Homo sapiens 84-94 17408725-0 2007 Fibrinogen Novy Jicin and Praha II: cases of hereditary Aalpha 16 Arg-->Cys and Aalpha 16 Arg-->His dysfibrinogenemia. Arginine 66-69 fibrinogen beta chain Homo sapiens 0-10 17408725-0 2007 Fibrinogen Novy Jicin and Praha II: cases of hereditary Aalpha 16 Arg-->Cys and Aalpha 16 Arg-->His dysfibrinogenemia. Cysteine 75-78 fibrinogen beta chain Homo sapiens 0-10 17408725-0 2007 Fibrinogen Novy Jicin and Praha II: cases of hereditary Aalpha 16 Arg-->Cys and Aalpha 16 Arg-->His dysfibrinogenemia. Arginine 93-96 fibrinogen beta chain Homo sapiens 0-10 17467041-0 2007 Different vulnerability of fibrinogen subunits to oxidative/nitrative modifications induced by peroxynitrite: functional consequences. Peroxynitrous Acid 95-108 fibrinogen beta chain Homo sapiens 27-37 17467041-1 2007 Based on previous studies suggesting that fibrinogen (Fg) might be a potential target for peroxynitrite (PN) action in plasma, we investigated the effects of PN on structure and hemostatic function of Fg in vitro. Peroxynitrous Acid 90-103 fibrinogen beta chain Homo sapiens 42-52 17467041-1 2007 Based on previous studies suggesting that fibrinogen (Fg) might be a potential target for peroxynitrite (PN) action in plasma, we investigated the effects of PN on structure and hemostatic function of Fg in vitro. Peroxynitrous Acid 90-103 fibrinogen beta chain Homo sapiens 54-56 17046817-9 2006 The sequestration of Zn(2+) ions from the N-terminal fibrinogen-binding region abrogated decorin incorporation into the fibrin network. Zinc 21-23 fibrinogen beta chain Homo sapiens 53-63 17063165-3 2006 Pentoxifylline, which improves red cell deformability, lowers fibrinogen levels and decreases platelet aggregation, has been used historically, but frequency of use has declined because of limited effectiveness. Pentoxifylline 0-14 fibrinogen beta chain Homo sapiens 62-72 17080220-3 2006 We investigated the effect of glucose control on fibrinogen glycation and fibrin network structure in type 2 diabetes. Glucose 30-37 fibrinogen beta chain Homo sapiens 49-59 17080220-8 2006 This was significantly reduced during the intervention (7.84 to 5.24 mol glucose / mol fibrinogen; p < 0.0002) in the diabetic group. Glucose 73-80 fibrinogen beta chain Homo sapiens 87-97 16860375-6 2007 Further, RGDS reduced platelet binding of (125)I-labelled fibrinogen IC-50"s of 35.5+/-3.2 (mean+/-SEM) and 20.7+/-2.2 microM for collagen- and ADP-stimulation respectively. Adenosine Diphosphate 144-147 fibrinogen beta chain Homo sapiens 58-68 16860375-8 2007 Additionally, PAC-1 reduced platelet bound of (125)I-labelled fibrinogen with IC-50"s of 9.0+/-1.4 and 4.1+/-2.2 microg/10(8) platelets for collagen- and ADP-stimulation respectively. Adenosine Diphosphate 154-157 fibrinogen beta chain Homo sapiens 62-72 17275886-9 2007 At baseline, plasma fibrinogen and Ks were significantly correlated to TcPO(2). Trichloroepoxypropane 71-75 fibrinogen beta chain Homo sapiens 20-30 17467041-2 2007 Using fluorescence and spectrophotometric methods, we estimated that about 0.5, 2 and 8 tyrosine residues per molecule were nitrated following the reaction of Fg at concentration 5.88 muM with 10, 100 and 1000 muM PN, respectively. Tyrosine 88-96 fibrinogen beta chain Homo sapiens 159-161 17467041-3 2007 At the same molar ratios of Fg to PN, about 0.01, 0.19 and 0.34 of tyrosine residues per molecule were oxidized to dityrosine and the amount of carbonyl groups in Fg increased 1.3-, 2,3- and 3.6-fold when compared to control Fg. Tyrosine 67-75 fibrinogen beta chain Homo sapiens 28-30 17467041-3 2007 At the same molar ratios of Fg to PN, about 0.01, 0.19 and 0.34 of tyrosine residues per molecule were oxidized to dityrosine and the amount of carbonyl groups in Fg increased 1.3-, 2,3- and 3.6-fold when compared to control Fg. Tyrosine 67-75 fibrinogen beta chain Homo sapiens 163-165 17467041-3 2007 At the same molar ratios of Fg to PN, about 0.01, 0.19 and 0.34 of tyrosine residues per molecule were oxidized to dityrosine and the amount of carbonyl groups in Fg increased 1.3-, 2,3- and 3.6-fold when compared to control Fg. Tyrosine 67-75 fibrinogen beta chain Homo sapiens 163-165 17467041-3 2007 At the same molar ratios of Fg to PN, about 0.01, 0.19 and 0.34 of tyrosine residues per molecule were oxidized to dityrosine and the amount of carbonyl groups in Fg increased 1.3-, 2,3- and 3.6-fold when compared to control Fg. dityrosine 115-125 fibrinogen beta chain Homo sapiens 28-30 17467041-3 2007 At the same molar ratios of Fg to PN, about 0.01, 0.19 and 0.34 of tyrosine residues per molecule were oxidized to dityrosine and the amount of carbonyl groups in Fg increased 1.3-, 2,3- and 3.6-fold when compared to control Fg. dityrosine 115-125 fibrinogen beta chain Homo sapiens 163-165 17467041-3 2007 At the same molar ratios of Fg to PN, about 0.01, 0.19 and 0.34 of tyrosine residues per molecule were oxidized to dityrosine and the amount of carbonyl groups in Fg increased 1.3-, 2,3- and 3.6-fold when compared to control Fg. dityrosine 115-125 fibrinogen beta chain Homo sapiens 163-165 17467041-4 2007 SDS-PAGE analysis of PN-modified Fg suggests that inter- and intramolecular dityrosine cross-links occur between A alpha chains of Fg. Sodium Dodecyl Sulfate 0-3 fibrinogen beta chain Homo sapiens 33-35 17467041-4 2007 SDS-PAGE analysis of PN-modified Fg suggests that inter- and intramolecular dityrosine cross-links occur between A alpha chains of Fg. Sodium Dodecyl Sulfate 0-3 fibrinogen beta chain Homo sapiens 131-133 17467041-4 2007 SDS-PAGE analysis of PN-modified Fg suggests that inter- and intramolecular dityrosine cross-links occur between A alpha chains of Fg. dityrosine 76-86 fibrinogen beta chain Homo sapiens 33-35 17467041-4 2007 SDS-PAGE analysis of PN-modified Fg suggests that inter- and intramolecular dityrosine cross-links occur between A alpha chains of Fg. dityrosine 76-86 fibrinogen beta chain Homo sapiens 131-133 17162709-1 2006 AIM: To compare the effects of 17beta-estradiol given intranasally (intranasal E2) and raloxifene on serum lipid profile and fibrinogen in hypercholesterolemic postmenopausal women. Estradiol 31-47 fibrinogen beta chain Homo sapiens 125-135 17162709-7 2006 Raloxifene caused a significant decrease in fibrinogen levels (p<0.05). Raloxifene Hydrochloride 0-10 fibrinogen beta chain Homo sapiens 44-54 17162709-9 2006 Raloxifene has a greater impact on fibrinogen than intranasal E2 application. Raloxifene Hydrochloride 0-10 fibrinogen beta chain Homo sapiens 35-45 17082723-5 2006 Resting norepinephrine predicted fibrinogen (beta = 0.42, P < 0.01) and D-dimer (beta = 0.37, P < 0.03), both independent of MBP. Norepinephrine 8-22 fibrinogen beta chain Homo sapiens 33-43 17082723-9 2006 The MBP-by-epinephrine AUC interaction predicted FVII:C AUC (beta = 0.28) and fibrinogen AUC (beta = -0.30), and the MBP-by-norepinephrine AUC interaction predicted FVIII:C AUC (beta = -0.28), all with borderline significance (Ps < 0.09) and independent of age and BMI. Epinephrine 11-22 fibrinogen beta chain Homo sapiens 78-88 16905184-4 2006 The in-situ adsorption mechanism and conformational change of fibrinogen on gold, titanium and hydroxyapatite surfaces were investigated by QCM-D technique and Fourier-transform infrared spectroscopy. Titanium 82-90 fibrinogen beta chain Homo sapiens 62-72 16905184-4 2006 The in-situ adsorption mechanism and conformational change of fibrinogen on gold, titanium and hydroxyapatite surfaces were investigated by QCM-D technique and Fourier-transform infrared spectroscopy. Durapatite 95-109 fibrinogen beta chain Homo sapiens 62-72 16905184-7 2006 This is explained by repulsion among fibrinogens, affecting water structure and thus the strength of fibrinogen interactions on the surface. Water 60-65 fibrinogen beta chain Homo sapiens 37-47 17122925-4 2006 Such pore-size depending responses were also found on membranes pre-coated with fibrinogen, but not with collagen or serum were in fact a much lower ROS production was observed. Reactive Oxygen Species 149-152 fibrinogen beta chain Homo sapiens 80-90 16847996-0 2006 Gastrodin interaction with human fibrinogen: anticoagulant effects and binding studies. gastrodin 0-9 fibrinogen beta chain Homo sapiens 33-43 16842952-8 2006 Platelet counts, ALT and fibrinogen levels in the VPA group were significantly lower than those in the controls. Valproic Acid 50-53 fibrinogen beta chain Homo sapiens 25-35 17015275-3 2006 Thermal treatment of pooled samples of human citrate-plasma or EDTA-plasma at 50 degrees C resulted in a rapid and parallel loss of fibrinogen concentration and AOPP reactivity. Edetic Acid 63-67 fibrinogen beta chain Homo sapiens 132-142 16944942-6 2006 The plasma expression of three fibrinogen gamma chain isoforms (FGG) was enhanced, whereas the expression of two isoforms of the fibrinogen beta chain (FGB) was reduced in the hypercholesterolemic patients compared with the CR group. Chromium 224-226 fibrinogen beta chain Homo sapiens 129-150 16944942-8 2006 Simvastatin treatment modified the plasma expression of FGG chain isoform 1, FGB chain isoforms 1 and 2, vitamin D binding protein isoform 3, apo A-IV, and haptoglobin isoform 2. Simvastatin 0-11 fibrinogen beta chain Homo sapiens 77-80 16944942-9 2006 The modification of FGG chain isoform 1 and FGB chain isoforms 1 and 2 was positively correlated with total plasma cholesterol level. Cholesterol 115-126 fibrinogen beta chain Homo sapiens 44-47 16881041-5 2006 Despite the difference in behavior between albumin (substantially non-adhesive) and fibrinogen (adhesive), the interactions of the polymers with proteins do not seem to be based on hydrophobic effects but on surface polar interactions. Polymers 131-139 fibrinogen beta chain Homo sapiens 84-94 16895881-10 2006 CONCLUSIONS: Postprandial concentrations of TF, fibrinogen, and PAI-1 are associated with the ratio of oleic to palmitic acid (MUFA:SFA) in dietary fats. oleic 103-108 fibrinogen beta chain Homo sapiens 48-58 16895881-10 2006 CONCLUSIONS: Postprandial concentrations of TF, fibrinogen, and PAI-1 are associated with the ratio of oleic to palmitic acid (MUFA:SFA) in dietary fats. Palmitic Acid 112-125 fibrinogen beta chain Homo sapiens 48-58 16895881-10 2006 CONCLUSIONS: Postprandial concentrations of TF, fibrinogen, and PAI-1 are associated with the ratio of oleic to palmitic acid (MUFA:SFA) in dietary fats. Fatty Acids, Monounsaturated 127-131 fibrinogen beta chain Homo sapiens 48-58 16895881-10 2006 CONCLUSIONS: Postprandial concentrations of TF, fibrinogen, and PAI-1 are associated with the ratio of oleic to palmitic acid (MUFA:SFA) in dietary fats. suppressive factor of allergy 132-135 fibrinogen beta chain Homo sapiens 48-58 16916124-7 2006 Atorvastatin significantly increased the levels of fibrinogen (p < 0.001), but it had no effect on other coagulation factors and homocysteine (p > 0.05). Atorvastatin 0-12 fibrinogen beta chain Homo sapiens 51-61 16831006-4 2006 For a mixed DPPC/fibrinogen layer at the interface, the amide I RA intensity-area hysteresis curves suggest that the fibrinogen molecules were expelled from the interface upon compression, apparently because of the presence of insoluble DPPC molecules. 1,2-Dipalmitoylphosphatidylcholine 12-16 fibrinogen beta chain Homo sapiens 117-127 16831006-4 2006 For a mixed DPPC/fibrinogen layer at the interface, the amide I RA intensity-area hysteresis curves suggest that the fibrinogen molecules were expelled from the interface upon compression, apparently because of the presence of insoluble DPPC molecules. Amides 56-61 fibrinogen beta chain Homo sapiens 17-27 16831006-4 2006 For a mixed DPPC/fibrinogen layer at the interface, the amide I RA intensity-area hysteresis curves suggest that the fibrinogen molecules were expelled from the interface upon compression, apparently because of the presence of insoluble DPPC molecules. Amides 56-61 fibrinogen beta chain Homo sapiens 117-127 16831006-4 2006 For a mixed DPPC/fibrinogen layer at the interface, the amide I RA intensity-area hysteresis curves suggest that the fibrinogen molecules were expelled from the interface upon compression, apparently because of the presence of insoluble DPPC molecules. 1,2-Dipalmitoylphosphatidylcholine 237-241 fibrinogen beta chain Homo sapiens 17-27 16831006-4 2006 For a mixed DPPC/fibrinogen layer at the interface, the amide I RA intensity-area hysteresis curves suggest that the fibrinogen molecules were expelled from the interface upon compression, apparently because of the presence of insoluble DPPC molecules. 1,2-Dipalmitoylphosphatidylcholine 237-241 fibrinogen beta chain Homo sapiens 117-127 16831006-5 2006 The squeeze-out of fibrinogen evidently removed a pronounced amount of DPPC from the interface, as judged from the corresponding nu(a)-CH2 intensity and wavenumber data. 1,2-Dipalmitoylphosphatidylcholine 71-75 fibrinogen beta chain Homo sapiens 19-29 16831006-7 2006 With the in situ IRRAS analysis of the mixed layer behavior at the interface, the induced loss of DPPC by fibrinogen expulsion from the compressed interface and the dominant adsorption of fibrinogen to the expanded interface were clearly demonstrated. 1,2-Dipalmitoylphosphatidylcholine 98-102 fibrinogen beta chain Homo sapiens 106-116 17723439-1 2006 Gold nanoparticles in size of 9.0 nm was prepared by the trisodium citrate and used to label goat anti-human fibrinogen. trisodium citrate 57-74 fibrinogen beta chain Homo sapiens 109-119 17723439-2 2006 In the pH 6.2 buffer solution and in the presence of polyethylene glycol (PEG), the immune reaction between gold-labeled goat anti-human fibrinogen and fibrinogen took place and the labeled gold nanoparticles were released from the goat anti-human fibrinogen, and the released gold particles aggregated which leaded the resonance scattering intensity at 560 nm (I560 nm) to enhance greatly. Polyethylene Glycols 53-72 fibrinogen beta chain Homo sapiens 137-147 17723439-2 2006 In the pH 6.2 buffer solution and in the presence of polyethylene glycol (PEG), the immune reaction between gold-labeled goat anti-human fibrinogen and fibrinogen took place and the labeled gold nanoparticles were released from the goat anti-human fibrinogen, and the released gold particles aggregated which leaded the resonance scattering intensity at 560 nm (I560 nm) to enhance greatly. Polyethylene Glycols 53-72 fibrinogen beta chain Homo sapiens 152-162 17723439-2 2006 In the pH 6.2 buffer solution and in the presence of polyethylene glycol (PEG), the immune reaction between gold-labeled goat anti-human fibrinogen and fibrinogen took place and the labeled gold nanoparticles were released from the goat anti-human fibrinogen, and the released gold particles aggregated which leaded the resonance scattering intensity at 560 nm (I560 nm) to enhance greatly. Polyethylene Glycols 53-72 fibrinogen beta chain Homo sapiens 152-162 17723439-2 2006 In the pH 6.2 buffer solution and in the presence of polyethylene glycol (PEG), the immune reaction between gold-labeled goat anti-human fibrinogen and fibrinogen took place and the labeled gold nanoparticles were released from the goat anti-human fibrinogen, and the released gold particles aggregated which leaded the resonance scattering intensity at 560 nm (I560 nm) to enhance greatly. Polyethylene Glycols 74-77 fibrinogen beta chain Homo sapiens 137-147 17723439-2 2006 In the pH 6.2 buffer solution and in the presence of polyethylene glycol (PEG), the immune reaction between gold-labeled goat anti-human fibrinogen and fibrinogen took place and the labeled gold nanoparticles were released from the goat anti-human fibrinogen, and the released gold particles aggregated which leaded the resonance scattering intensity at 560 nm (I560 nm) to enhance greatly. Polyethylene Glycols 74-77 fibrinogen beta chain Homo sapiens 152-162 17723439-2 2006 In the pH 6.2 buffer solution and in the presence of polyethylene glycol (PEG), the immune reaction between gold-labeled goat anti-human fibrinogen and fibrinogen took place and the labeled gold nanoparticles were released from the goat anti-human fibrinogen, and the released gold particles aggregated which leaded the resonance scattering intensity at 560 nm (I560 nm) to enhance greatly. Polyethylene Glycols 74-77 fibrinogen beta chain Homo sapiens 152-162 16675719-7 2006 CONCLUSIONS: Higher intake of iron, sugar, and caffeine, in addition to obesity, account largely for higher fibrinogen levels with Westernized lifestyle. Iron 30-34 fibrinogen beta chain Homo sapiens 108-118 16819336-0 2006 Fibrinogen gamma375 arg-->trp mutation (fibrinogen aguadilla) causes hereditary hypofibrinogenemia, hepatic endoplasmic reticulum storage disease and cirrhosis. Tryptophan 29-32 fibrinogen beta chain Homo sapiens 0-10 16819336-0 2006 Fibrinogen gamma375 arg-->trp mutation (fibrinogen aguadilla) causes hereditary hypofibrinogenemia, hepatic endoplasmic reticulum storage disease and cirrhosis. Tryptophan 29-32 fibrinogen beta chain Homo sapiens 43-53 16675719-7 2006 CONCLUSIONS: Higher intake of iron, sugar, and caffeine, in addition to obesity, account largely for higher fibrinogen levels with Westernized lifestyle. Sugars 36-41 fibrinogen beta chain Homo sapiens 108-118 16675719-7 2006 CONCLUSIONS: Higher intake of iron, sugar, and caffeine, in addition to obesity, account largely for higher fibrinogen levels with Westernized lifestyle. Caffeine 47-55 fibrinogen beta chain Homo sapiens 108-118 16574890-5 2006 In a regression model, including age and fibrinogen, plasma tHcy was an independent predictor of clot permeation and fibrinolysis time in healthy subjects (R2=0.88, P<0.0001 and R2=0.54, P<0.0001, respectively). thcy 60-64 fibrinogen beta chain Homo sapiens 41-51 16549375-6 2006 METHODS: Platelet activation was measured using whole-blood flow cytometric measurement of ADP-stimulated fibrinogen binding at baseline and 12h after administration of a loading dose of 300 mg clopidogrel. Adenosine Diphosphate 91-94 fibrinogen beta chain Homo sapiens 106-116 16626977-1 2006 Recently, sequences from two nuclear genes (exon 6 of the dentin matrix protein 1 gene and intron 7 of the beta-fibrinogen gene) and one mitochondrial gene (cytochrome b gene) were used independently in an attempt to resolve phylogenetic relationships within the neotomine-peromyscine complex. neotomine 263-272 fibrinogen beta chain Homo sapiens 107-122 16756602-7 2006 RESULTS: The cryoprecipitates treated with either 2% TnBP or 1% TnBP + 1% Triton X-45 showed excellent (> 93%) mean recovery of coagulant factor VIII (FVIII), ristocetin cofactor Von Willebrand factor (VWF:RCo), and clottable fibrinogen activity. tributyl phosphate 64-68 fibrinogen beta chain Homo sapiens 229-239 16546333-5 2006 Daptomycin macromolecular conjugates were characterized by drug loading, drug release, and binding affinity for fibrinogen using HPLC analysis and surface plasmon resonance. Daptomycin 0-10 fibrinogen beta chain Homo sapiens 112-122 16549375-12 2006 Amongst the remaining 55 patients, the mean reduction in fibrinogen binding after clopidogrel administration was 51.5% (95% CI: 43.8-59.2). Clopidogrel 82-93 fibrinogen beta chain Homo sapiens 57-67 16549375-13 2006 Amongst responders there was a wide variability in reduction of fibrinogen binding in response to clopidogrel (range 8.11-97.7%). Clopidogrel 98-109 fibrinogen beta chain Homo sapiens 64-74 16784967-4 2006 A marked decrease in the plasma levels of plasminogen activator inhibitor 1 (by 42%) and fibrinogen (by 27%) was observed in the acarbose group at the end of the study, whereas no significant changes in the levels of these parameters were observed in the control group. Acarbose 129-137 fibrinogen beta chain Homo sapiens 89-99 16784972-2 2006 In both triglyceride subgroups, raloxifene significantly improved low-density lipoprotein cholesterol, total cholesterol, non-high-density lipoprotein cholesterol (HDL-C), apolipoprotein B, apolipoprotein A-I, and fibrinogen compared with placebo (P < .05). Raloxifene Hydrochloride 32-42 fibrinogen beta chain Homo sapiens 214-224 16756602-7 2006 RESULTS: The cryoprecipitates treated with either 2% TnBP or 1% TnBP + 1% Triton X-45 showed excellent (> 93%) mean recovery of coagulant factor VIII (FVIII), ristocetin cofactor Von Willebrand factor (VWF:RCo), and clottable fibrinogen activity. Octoxynol 74-85 fibrinogen beta chain Homo sapiens 229-239 16756602-10 2006 CONCLUSIONS: Viral inactivation treatment by TnBP, with or without Triton X-45, can be applied to minipools of cryoprecipitate, with good recovery of FVIII, VWF and fibrinogen. tributyl phosphate 45-49 fibrinogen beta chain Homo sapiens 165-175 16457880-6 2006 For fibrinogen PEGylation (performed in the solution phase), PEG-NHS was more reactive than PEG-ISO or PEG-DISO. peg-nhs 61-68 fibrinogen beta chain Homo sapiens 4-14 16457880-6 2006 For fibrinogen PEGylation (performed in the solution phase), PEG-NHS was more reactive than PEG-ISO or PEG-DISO. peg-iso 92-99 fibrinogen beta chain Homo sapiens 4-14 16574890-6 2006 In CAD patients, tHcy and fibrinogen were stronger predictors of the permeation coefficient (R2=0.84; P<0.0001) than was fibrinogen alone (R2=0.66; P<0.0001), whereas tHcy was the only predictor of lysis time (R2=0.69; P<0.0001). thcy 173-177 fibrinogen beta chain Homo sapiens 26-36 16457880-6 2006 For fibrinogen PEGylation (performed in the solution phase), PEG-NHS was more reactive than PEG-ISO or PEG-DISO. peg-diso 103-111 fibrinogen beta chain Homo sapiens 4-14 16457880-8 2006 A marked reduction in platelet adhesion was observed on fibrinogen-adsorbed polyurethane treated with PEG-NHS or PEG-DISO. Polyurethanes 76-88 fibrinogen beta chain Homo sapiens 56-66 16574890-11 2006 Our data are consistent with a mechanism of thrombosis in hyperhomocysteinemia, which involves modification of fibrinogen by Hcy-thiolactone. homocysteine thiolactone 125-140 fibrinogen beta chain Homo sapiens 111-121 16457880-8 2006 A marked reduction in platelet adhesion was observed on fibrinogen-adsorbed polyurethane treated with PEG-NHS or PEG-DISO. peg-nhs 102-109 fibrinogen beta chain Homo sapiens 56-66 16466648-5 2006 Ethanol precipitation of plasma removed fibrinogen and prevented the immunofixation of the protein by the IgA antiserum. Ethanol 0-7 fibrinogen beta chain Homo sapiens 40-50 16457880-8 2006 A marked reduction in platelet adhesion was observed on fibrinogen-adsorbed polyurethane treated with PEG-NHS or PEG-DISO. peg-diso 113-121 fibrinogen beta chain Homo sapiens 56-66 16457880-9 2006 Relative differences in platelet adhesion on PEG-NHS and PEG-DISO modified surfaces could be attributed to differences in reactivity towards fibrinogen and the size of the polymer backbone. Polyethylene Glycols 45-48 fibrinogen beta chain Homo sapiens 141-151 16457880-9 2006 Relative differences in platelet adhesion on PEG-NHS and PEG-DISO modified surfaces could be attributed to differences in reactivity towards fibrinogen and the size of the polymer backbone. Polyethylene Glycols 57-60 fibrinogen beta chain Homo sapiens 141-151 16457880-9 2006 Relative differences in platelet adhesion on PEG-NHS and PEG-DISO modified surfaces could be attributed to differences in reactivity towards fibrinogen and the size of the polymer backbone. diso 61-65 fibrinogen beta chain Homo sapiens 141-151 16678391-12 2006 These rearrangements were presumably facilitated on the heparinized silica by enhanced lateral mobility of fibrinogen at this negatively charged, highly hydrophilic interface. Silicon Dioxide 68-74 fibrinogen beta chain Homo sapiens 107-117 16700602-5 2006 The elutability of adsorbed fibrinogen by Triton X-100, studied with SPR, decreased from 90 +/- 5 to 6 +/- 2% after conversion to fibrin. Octoxynol 42-54 fibrinogen beta chain Homo sapiens 28-38 16443328-6 2006 Smokers with the Fgbeta CT/TT or APOEepsilon4epsilon3 genotype, as well as individuals with the Fgbeta CT/TT genotype who consumed alcohol were more likely to develop a stroke. Alcohols 131-138 fibrinogen beta chain Homo sapiens 96-102 16154147-1 2006 BACKGROUND: Hydroxyethyl starch administration has been associated with decreases in hemostasis and has recently been demonstrated to decrease fibrinogen (FI)-thrombin-(FIIa)-Factor XIII (FXIII) interactions in vitro in human plasma. Hydroxyethyl starch 12-31 fibrinogen beta chain Homo sapiens 143-153 16643450-3 2006 Low calcium ionophore (A23187) concentrations induced Fg binding but not annexin V binding. Calcium 4-11 fibrinogen beta chain Homo sapiens 54-56 16643450-3 2006 Low calcium ionophore (A23187) concentrations induced Fg binding but not annexin V binding. Calcimycin 23-29 fibrinogen beta chain Homo sapiens 54-56 16551923-0 2006 Fibrinogen concentrate reverses dilutional coagulopathy induced in vitro by saline but not by hydroxyethyl starch 6%. Sodium Chloride 76-82 fibrinogen beta chain Homo sapiens 0-10 16875159-7 2006 The micronized fenofibrate caused a significant decrease in serum total cholesterol (by 15%), TG (by 38%), CRP (by 35%), fibrinogen (by 26%) and TBARS (by 33%) concentrations associated with a increase in CAT (by 35%), GSH-Px (by 63%), SOD (by 31%) activities. Fenofibrate 15-26 fibrinogen beta chain Homo sapiens 121-131 16600577-0 2006 Human fibrinogen adsorption onto single-walled carbon nanotube films. Carbon 47-53 fibrinogen beta chain Homo sapiens 6-16 16600577-1 2006 The adsorption behavior of human fibrinogen (Hfg) on single-walled carbon nanotube (SWNT) films was investigated using scanning electron microscopy (SEM) and near edge X-ray absorption fine structure (NEXAFS) spectroscopy. Carbon 67-73 fibrinogen beta chain Homo sapiens 33-43 16551923-8 2006 The addition of fibrinogen reconstituted the clot firmness in the presence of NaCl 0.9%, but this had only a minor effect after dilution with HES 6%. Sodium Chloride 78-82 fibrinogen beta chain Homo sapiens 16-26 16488424-0 2006 Interaction of fibrinogen with n-alkylagaroses and its purification by critical hydrophobicity hydrophobic interaction chromatograpy. n-alkylagaroses 31-46 fibrinogen beta chain Homo sapiens 15-25 16226763-5 2006 The EG(n)-attached PAMAM surfaces with n = 3 reduced the adsorption of fibrinogen to approximately 20% monolayer, whereas 2-3% for n = 4 or 6. pamam 19-24 fibrinogen beta chain Homo sapiens 71-81 16488424-8 2006 For fibrinogen purification the critical hydrohobicity gel, Seph-C5 (13 micromol/ml packed gel), was selected. seph-c5 60-67 fibrinogen beta chain Homo sapiens 4-14 16488424-9 2006 With the help of the cosolvents NaCl or glycine a fully reversible adsorption of fibrinogen could be facilitated on the critical hydrophobicity gel. Sodium Chloride 32-36 fibrinogen beta chain Homo sapiens 81-91 16488424-9 2006 With the help of the cosolvents NaCl or glycine a fully reversible adsorption of fibrinogen could be facilitated on the critical hydrophobicity gel. glycine a 40-49 fibrinogen beta chain Homo sapiens 81-91 16519458-0 2006 Fibrinogen adsorption on three silica-based surfaces: conformation and kinetics. Silicon Dioxide 31-37 fibrinogen beta chain Homo sapiens 0-10 16526745-0 2006 Vibrational spectroscopic studies on fibrinogen adsorption at polystyrene/protein solution interfaces: hydrophobic side chain and secondary structure changes. Polystyrenes 62-73 fibrinogen beta chain Homo sapiens 37-47 16526745-1 2006 Structural changes of fibrinogen after adsorption to polystyrene (PS) were examined at the PS/protein solution interface in situ using sum frequency generation (SFG) vibrational spectroscopy and attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR). Polystyrenes 53-64 fibrinogen beta chain Homo sapiens 22-32 16526745-1 2006 Structural changes of fibrinogen after adsorption to polystyrene (PS) were examined at the PS/protein solution interface in situ using sum frequency generation (SFG) vibrational spectroscopy and attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR). Polystyrenes 66-68 fibrinogen beta chain Homo sapiens 22-32 16526745-3 2006 Our results indicate that upon adsorption, the hydrophobic PS surface induces fast structural changes of fibrinogen molecules by aligning some hydrophobic side chains in fibrinogen so that they face to the surface. Polystyrenes 59-61 fibrinogen beta chain Homo sapiens 105-115 16526745-3 2006 Our results indicate that upon adsorption, the hydrophobic PS surface induces fast structural changes of fibrinogen molecules by aligning some hydrophobic side chains in fibrinogen so that they face to the surface. Polystyrenes 59-61 fibrinogen beta chain Homo sapiens 170-180 16458339-3 2006 The proteolytic activity of LV-PA alone or previously incubated with human plasminogen (Plg) on the large molecular mass protein substrates, dimethylcasein (DMC) and fibrinogen (Fg) was completely inhibited by human alpha2-M. lv-pa 28-33 fibrinogen beta chain Homo sapiens 166-176 16488689-10 2006 CONCLUSIONS: For patients undergoing high-risk open heart surgery and receiving tranexamic acid, a phosphorylcholine-coated oxygenator may reduce intraoperative thrombin formation and the associated consumption of platelets, fibrinogen, and antithrombin. Tranexamic Acid 80-95 fibrinogen beta chain Homo sapiens 225-235 16678391-0 2006 Protein concentration and adsorption time effects on fibrinogen adsorption at heparinized silica interfaces. Silicon Dioxide 90-96 fibrinogen beta chain Homo sapiens 53-63 16678391-6 2006 Under all experimental conditions, fibrinogen adsorbed at a lower rate and to a lower extent on heparinized as compared to unheparinized silica. Silicon Dioxide 137-143 fibrinogen beta chain Homo sapiens 35-45 16678391-7 2006 In addition, buffer elution experiments showed that fibrinogen was less tightly bound to heparinized silica. Silicon Dioxide 101-107 fibrinogen beta chain Homo sapiens 52-62 16229829-0 2006 A novel variant fibrinogen, deletion of Bbeta111Ser in coiled-coil region, affecting fibrin lateral aggregation. bbeta111ser 40-51 fibrinogen beta chain Homo sapiens 16-26 16529427-12 2006 Fibrinogen adsorption and platelet adhesion were significantly lower for the hydrogels than for the control polyurethane, whereas albumin adsorption increased for the hydrogels in proportion to the contents of poly(glycerol methacrylate). Polyurethanes 108-120 fibrinogen beta chain Homo sapiens 0-10 16229829-4 2006 We suggested that the discrepancy of fibrinogen values among 3 assays was caused by the difference in NaCl concentration in reagents for determination and analyzed the polymerization under the conditions of various NaCl concentrations. Sodium Chloride 102-106 fibrinogen beta chain Homo sapiens 37-47 16229829-4 2006 We suggested that the discrepancy of fibrinogen values among 3 assays was caused by the difference in NaCl concentration in reagents for determination and analyzed the polymerization under the conditions of various NaCl concentrations. Sodium Chloride 215-219 fibrinogen beta chain Homo sapiens 37-47 16229829-5 2006 Although under normal physiological conditions Kyoto IV fibrinogen augmented the polymerization as compared with normal control, in 0.21 mol/l NaCl Kyoto IV fibrinogen showed abruptly impaired polymerization curve compared with normal control. Sodium Chloride 143-147 fibrinogen beta chain Homo sapiens 157-167 16487444-17 2006 Serum TC levels were positively correlated with plasma fibrinogen levels (r: 0.72, P < 0.05). Technetium 6-8 fibrinogen beta chain Homo sapiens 55-65 16229829-6 2006 CONCLUSION: Variant fibrinogen, BbetaDelta111Ser, showed augmented lateral aggregation under normal physiological conditions and the residue located in coiled-coil region, Bbeta111Ser, plays an important role in the lateral aggregation. bbeta111ser 172-183 fibrinogen beta chain Homo sapiens 20-30 16487444-19 2006 Also, in patients with SHypo, serum TG levels were positively correlated with serum TSH levels (r: 0.42, P < 0.05), plasma activities of factors V, VII and X (r: 0.42, P < 0.05; r: 0.54, P < 0.01; r: 0.57, P < 0.01, respectively) and negatively correlated with plasma fibrinogen levels (r: -0.41, P < 0.05). Thioguanine 36-38 fibrinogen beta chain Homo sapiens 280-290 16555112-1 2006 The influence of different surface modifications with poly(ethyleneglycol) (PEG) layers on the adsorption of fibrinogen and the adhesion and activation of macrophage-like human leukocytes was investigated. Polyethylene Glycols 54-74 fibrinogen beta chain Homo sapiens 109-119 16562643-0 2006 [Changes in serum lipids, plasma fibrinogen and other haemostatic parameters induced by ciprofibrate action in hyperlipidemic patients with and without coronary artery disease]. ciprofibrate 88-100 fibrinogen beta chain Homo sapiens 33-43 16562643-2 2006 The objective of this investigation was a drug intervention with ciprofibrat in hyperlipidemic people with high level of plasmatic fibrinogen with the purpose of knowing the effects of the drug over these risk factors and other haemostatic parameters. ciprofibrat 65-76 fibrinogen beta chain Homo sapiens 131-141 16477507-0 2006 Fibrinogen-beta-estradiol binding studied by fluorescence spectroscopy: denaturation and pH effects. Estradiol 11-25 fibrinogen beta chain Homo sapiens 0-10 16477507-2 2006 It is known that erythrocyte aggregation increases in the presence of fibrinogen, and that beta-estradiol decreases erythrocyte aggregation with a constant fibrinogen concentration. Estradiol 91-105 fibrinogen beta chain Homo sapiens 156-166 16477507-3 2006 In this work, we have used intrinsic tryptophan fluorescence to obtain information on the conformational changes of fibrinogen upon the recently proposed interaction with beta-estradiol. Tryptophan 37-47 fibrinogen beta chain Homo sapiens 116-126 16477507-3 2006 In this work, we have used intrinsic tryptophan fluorescence to obtain information on the conformational changes of fibrinogen upon the recently proposed interaction with beta-estradiol. Estradiol 171-185 fibrinogen beta chain Homo sapiens 116-126 16555112-6 2006 The results showed that PEGylated surfaces adsorbed significantly less (up to 90% less) fibrinogen, and that unfolding of adsorbed fibrinogen was more pronounced on the linear mPEG layers than on the PEG-like plasma polymer surfaces. monomethoxypolyethylene glycol 176-180 fibrinogen beta chain Homo sapiens 131-141 16555112-6 2006 The results showed that PEGylated surfaces adsorbed significantly less (up to 90% less) fibrinogen, and that unfolding of adsorbed fibrinogen was more pronounced on the linear mPEG layers than on the PEG-like plasma polymer surfaces. Polyethylene Glycols 24-27 fibrinogen beta chain Homo sapiens 88-98 16555112-6 2006 The results showed that PEGylated surfaces adsorbed significantly less (up to 90% less) fibrinogen, and that unfolding of adsorbed fibrinogen was more pronounced on the linear mPEG layers than on the PEG-like plasma polymer surfaces. Polymers 216-223 fibrinogen beta chain Homo sapiens 131-141 16243393-7 2006 Increased concentrations of the synthetic PEG are used to further alter the network structure of the PEG-fibrinogen hydrogel. Polyethylene Glycols 42-45 fibrinogen beta chain Homo sapiens 105-115 16484048-0 2006 Fibrinogen is a co-antioxidant that supplements the vitamin E analog trolox in a model system. Vitamin E 52-61 fibrinogen beta chain Homo sapiens 0-10 16484048-0 2006 Fibrinogen is a co-antioxidant that supplements the vitamin E analog trolox in a model system. 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid 69-75 fibrinogen beta chain Homo sapiens 0-10 16484048-4 2006 We hypothesized that fibrinogen can act as a co-antioxidant to supplement vitamin E thereby eliminating its oxidative effect under prooxidant conditions. Vitamin E 74-83 fibrinogen beta chain Homo sapiens 21-31 16484048-11 2006 CONCLUSIONS: The data indicated that fibrinogen did act as a co-antioxidant to supplement Trolox and eliminate its prooxidant effect, most probably, by directly quenching the phenoxyl radical, because unlike vitamin C, fibrinogen did not appear to recycle vitamin E. 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid 90-96 fibrinogen beta chain Homo sapiens 37-47 16484048-11 2006 CONCLUSIONS: The data indicated that fibrinogen did act as a co-antioxidant to supplement Trolox and eliminate its prooxidant effect, most probably, by directly quenching the phenoxyl radical, because unlike vitamin C, fibrinogen did not appear to recycle vitamin E. phenoxyl 175-183 fibrinogen beta chain Homo sapiens 37-47 16484048-11 2006 CONCLUSIONS: The data indicated that fibrinogen did act as a co-antioxidant to supplement Trolox and eliminate its prooxidant effect, most probably, by directly quenching the phenoxyl radical, because unlike vitamin C, fibrinogen did not appear to recycle vitamin E. Ascorbic Acid 208-217 fibrinogen beta chain Homo sapiens 37-47 16484048-11 2006 CONCLUSIONS: The data indicated that fibrinogen did act as a co-antioxidant to supplement Trolox and eliminate its prooxidant effect, most probably, by directly quenching the phenoxyl radical, because unlike vitamin C, fibrinogen did not appear to recycle vitamin E. Vitamin E 256-265 fibrinogen beta chain Homo sapiens 37-47 16484048-12 2006 But fibrinogen may act as a universal antioxidant, since unlike Trolox and vitamin C, it showed little tendency toward becoming a prooxidant. Ascorbic Acid 75-84 fibrinogen beta chain Homo sapiens 4-14 16555112-1 2006 The influence of different surface modifications with poly(ethyleneglycol) (PEG) layers on the adsorption of fibrinogen and the adhesion and activation of macrophage-like human leukocytes was investigated. Polyethylene Glycols 76-79 fibrinogen beta chain Homo sapiens 109-119 16099496-4 2006 Fibrinogen adsorption from tris-buffered saline at pH 7.4 decreased significantly with increasing graft density and/or chain length of poly(MPC) and reached a level of < 10 ng/cm2 at graft density > or = 0.29 chains/nm2 and chain length > or = 100 units, compared to ca. tris-buffered saline 27-47 fibrinogen beta chain Homo sapiens 0-10 16115641-1 2006 The competitive adsorption of fibrinogen (FB) and DPPC at the air/aqueous interface, in phosphate buffer saline at 25 degrees C, was studied with tensiometry, infrared reflection absorption spectroscopy (IRRAS), and ellipsometry. Phosphates 88-97 fibrinogen beta chain Homo sapiens 30-40 16115641-1 2006 The competitive adsorption of fibrinogen (FB) and DPPC at the air/aqueous interface, in phosphate buffer saline at 25 degrees C, was studied with tensiometry, infrared reflection absorption spectroscopy (IRRAS), and ellipsometry. Sodium Chloride 105-111 fibrinogen beta chain Homo sapiens 30-40 16115641-2 2006 For FB/DPPC mixtures with 750 ppm (0.075 wt%) FB and 1000 ppm (0.10 wt%) DPPC, the tension behavior was found to be similar to that of FB when alone, even with DPPC and FB being at the interface. 1,2-Dipalmitoylphosphatidylcholine 7-11 fibrinogen beta chain Homo sapiens 46-48 16115641-2 2006 For FB/DPPC mixtures with 750 ppm (0.075 wt%) FB and 1000 ppm (0.10 wt%) DPPC, the tension behavior was found to be similar to that of FB when alone, even with DPPC and FB being at the interface. 1,2-Dipalmitoylphosphatidylcholine 7-11 fibrinogen beta chain Homo sapiens 46-48 16115641-2 2006 For FB/DPPC mixtures with 750 ppm (0.075 wt%) FB and 1000 ppm (0.10 wt%) DPPC, the tension behavior was found to be similar to that of FB when alone, even with DPPC and FB being at the interface. 1,2-Dipalmitoylphosphatidylcholine 7-11 fibrinogen beta chain Homo sapiens 46-48 16115641-2 2006 For FB/DPPC mixtures with 750 ppm (0.075 wt%) FB and 1000 ppm (0.10 wt%) DPPC, the tension behavior was found to be similar to that of FB when alone, even with DPPC and FB being at the interface. 1,2-Dipalmitoylphosphatidylcholine 73-77 fibrinogen beta chain Homo sapiens 4-6 16115641-2 2006 For FB/DPPC mixtures with 750 ppm (0.075 wt%) FB and 1000 ppm (0.10 wt%) DPPC, the tension behavior was found to be similar to that of FB when alone, even with DPPC and FB being at the interface. 1,2-Dipalmitoylphosphatidylcholine 73-77 fibrinogen beta chain Homo sapiens 4-6 16115641-3 2006 Thus, FB interferes with adsorption of DPPC and inhibits its surface tension lowering ability. 1,2-Dipalmitoylphosphatidylcholine 39-43 fibrinogen beta chain Homo sapiens 6-8 16115641-4 2006 When FB protein is introduced in the solution after a DPPC monolayer has formed, the adsorption of FB is inhibited by the DPPC monolayer. 1,2-Dipalmitoylphosphatidylcholine 54-58 fibrinogen beta chain Homo sapiens 5-7 16115641-4 2006 When FB protein is introduced in the solution after a DPPC monolayer has formed, the adsorption of FB is inhibited by the DPPC monolayer. 1,2-Dipalmitoylphosphatidylcholine 54-58 fibrinogen beta chain Homo sapiens 99-101 16115641-4 2006 When FB protein is introduced in the solution after a DPPC monolayer has formed, the adsorption of FB is inhibited by the DPPC monolayer. 1,2-Dipalmitoylphosphatidylcholine 122-126 fibrinogen beta chain Homo sapiens 5-7 16115641-4 2006 When FB protein is introduced in the solution after a DPPC monolayer has formed, the adsorption of FB is inhibited by the DPPC monolayer. 1,2-Dipalmitoylphosphatidylcholine 122-126 fibrinogen beta chain Homo sapiens 99-101 16115641-5 2006 When a DPPC monolayer is spread onto a solution with a preadsorbed FB layer, the DPPC monolayer excludes FB from the surface and controls the tension behavior with little inhibition by FB. 1,2-Dipalmitoylphosphatidylcholine 7-11 fibrinogen beta chain Homo sapiens 67-69 16115641-5 2006 When a DPPC monolayer is spread onto a solution with a preadsorbed FB layer, the DPPC monolayer excludes FB from the surface and controls the tension behavior with little inhibition by FB. 1,2-Dipalmitoylphosphatidylcholine 7-11 fibrinogen beta chain Homo sapiens 105-107 16115641-5 2006 When a DPPC monolayer is spread onto a solution with a preadsorbed FB layer, the DPPC monolayer excludes FB from the surface and controls the tension behavior with little inhibition by FB. 1,2-Dipalmitoylphosphatidylcholine 7-11 fibrinogen beta chain Homo sapiens 105-107 16115641-5 2006 When a DPPC monolayer is spread onto a solution with a preadsorbed FB layer, the DPPC monolayer excludes FB from the surface and controls the tension behavior with little inhibition by FB. 1,2-Dipalmitoylphosphatidylcholine 81-85 fibrinogen beta chain Homo sapiens 67-69 16115641-5 2006 When a DPPC monolayer is spread onto a solution with a preadsorbed FB layer, the DPPC monolayer excludes FB from the surface and controls the tension behavior with little inhibition by FB. 1,2-Dipalmitoylphosphatidylcholine 81-85 fibrinogen beta chain Homo sapiens 105-107 16115641-5 2006 When a DPPC monolayer is spread onto a solution with a preadsorbed FB layer, the DPPC monolayer excludes FB from the surface and controls the tension behavior with little inhibition by FB. 1,2-Dipalmitoylphosphatidylcholine 81-85 fibrinogen beta chain Homo sapiens 105-107 16115641-6 2006 When a DPPC dispersion is introduced with the Trurnit method, or sprayed dropwise, onto an aqueous FB/DPPC surfaces, the DPPC layer formed on the surface prevents the adsorption of FB and dominates the surface tension behavior. 1,2-Dipalmitoylphosphatidylcholine 7-11 fibrinogen beta chain Homo sapiens 99-101 16115641-6 2006 When a DPPC dispersion is introduced with the Trurnit method, or sprayed dropwise, onto an aqueous FB/DPPC surfaces, the DPPC layer formed on the surface prevents the adsorption of FB and dominates the surface tension behavior. 1,2-Dipalmitoylphosphatidylcholine 7-11 fibrinogen beta chain Homo sapiens 181-183 16115641-6 2006 When a DPPC dispersion is introduced with the Trurnit method, or sprayed dropwise, onto an aqueous FB/DPPC surfaces, the DPPC layer formed on the surface prevents the adsorption of FB and dominates the surface tension behavior. 1,2-Dipalmitoylphosphatidylcholine 102-106 fibrinogen beta chain Homo sapiens 181-183 16115641-6 2006 When a DPPC dispersion is introduced with the Trurnit method, or sprayed dropwise, onto an aqueous FB/DPPC surfaces, the DPPC layer formed on the surface prevents the adsorption of FB and dominates the surface tension behavior. 1,2-Dipalmitoylphosphatidylcholine 102-106 fibrinogen beta chain Homo sapiens 181-183 16756193-11 2006 Flowcytometry for P-selectin expression and fibrinogen binding to platelets can be used to monitor antiplatelet therapy with aspirin following acute myocardial infarction. Aspirin 125-132 fibrinogen beta chain Homo sapiens 44-54 16421942-1 2006 The migration of fibrinogen peptides in capillaries coated with G-quartet-forming DNA oligonucleotides in open-tubular CEC (OTCEC) was studied, in order to investigate factors affecting the retention of peptides on G-quartet DNA stationary phases. Oligonucleotides 86-102 fibrinogen beta chain Homo sapiens 17-27 16303831-6 2006 RESULTS: Elevated fibrinogen levels (>3.25 g/liter) were observed in 14 subjects with increased serum TSH levels (32.6%), 973 euthyroid subjects (28.9%), 158 subjects with decreased serum TSH levels (40.7%), and six individuals with overt hyperthyroidism (54.4%). Thyrotropin 105-108 fibrinogen beta chain Homo sapiens 18-28 16270338-6 2006 The oxygen-ion-implanted nitinol surface adsorbed less fibrinogen on its surface and activated the contact system less than the untreated nitinol surface, but conformation changes of fibrinogen were higher on the oxygen-implanted nitinol. Oxygen 4-10 fibrinogen beta chain Homo sapiens 55-65 16270338-6 2006 The oxygen-ion-implanted nitinol surface adsorbed less fibrinogen on its surface and activated the contact system less than the untreated nitinol surface, but conformation changes of fibrinogen were higher on the oxygen-implanted nitinol. Oxygen 4-10 fibrinogen beta chain Homo sapiens 183-193 16270338-6 2006 The oxygen-ion-implanted nitinol surface adsorbed less fibrinogen on its surface and activated the contact system less than the untreated nitinol surface, but conformation changes of fibrinogen were higher on the oxygen-implanted nitinol. nitinol 25-32 fibrinogen beta chain Homo sapiens 55-65 16270338-6 2006 The oxygen-ion-implanted nitinol surface adsorbed less fibrinogen on its surface and activated the contact system less than the untreated nitinol surface, but conformation changes of fibrinogen were higher on the oxygen-implanted nitinol. nitinol 25-32 fibrinogen beta chain Homo sapiens 183-193 16270338-6 2006 The oxygen-ion-implanted nitinol surface adsorbed less fibrinogen on its surface and activated the contact system less than the untreated nitinol surface, but conformation changes of fibrinogen were higher on the oxygen-implanted nitinol. Oxygen 213-219 fibrinogen beta chain Homo sapiens 183-193 16303831-6 2006 RESULTS: Elevated fibrinogen levels (>3.25 g/liter) were observed in 14 subjects with increased serum TSH levels (32.6%), 973 euthyroid subjects (28.9%), 158 subjects with decreased serum TSH levels (40.7%), and six individuals with overt hyperthyroidism (54.4%). Thyrotropin 191-194 fibrinogen beta chain Homo sapiens 18-28 16303831-7 2006 Logistic regression analysis revealed decreased serum TSH as an independent risk factor for elevated fibrinogen levels (odds ratio, 1.42; 95% confidence interval, 1.12-1.80). Thyrotropin 54-57 fibrinogen beta chain Homo sapiens 101-111 16303831-9 2006 Decreased serum TSH is an independent risk factor for elevated plasma fibrinogen levels as a possible explanation for the high cardiovascular mortality among affected subjects. Thyrotropin 16-19 fibrinogen beta chain Homo sapiens 70-80 16420577-2 2006 Platelet agonists such as thrombin and adenosine diphosphate (ADP) lead to the activation of alpha(IIb)beta(3), thereby enhancing its affinity and avidity for binding fibrinogen (inside-out signaling). Adenosine Diphosphate 39-60 fibrinogen beta chain Homo sapiens 167-177 16420577-2 2006 Platelet agonists such as thrombin and adenosine diphosphate (ADP) lead to the activation of alpha(IIb)beta(3), thereby enhancing its affinity and avidity for binding fibrinogen (inside-out signaling). Adenosine Diphosphate 62-65 fibrinogen beta chain Homo sapiens 167-177 20641599-5 2004 A tripeptide sequence consisting of Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3. tripeptide K-26 2-12 fibrinogen beta chain Homo sapiens 149-159 20641599-5 2004 A tripeptide sequence consisting of Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3. Arginine 36-39 fibrinogen beta chain Homo sapiens 149-159 20641599-5 2004 A tripeptide sequence consisting of Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3. glycylaspartic acid 40-47 fibrinogen beta chain Homo sapiens 149-159 16378437-0 2006 Colloid probe AFM investigation of interactions between fibrinogen and PEG-like plasma polymer surfaces. Polymers 87-94 fibrinogen beta chain Homo sapiens 56-66 16378437-1 2006 Interaction forces between surfaces designed to be protein resistant and fibrinogen (Fg) were investigated in phosphate-buffered saline with colloid probe atomic force microscopy. Phosphate-Buffered Saline 110-135 fibrinogen beta chain Homo sapiens 73-83 16378437-2 2006 The surfaces of the silica probes were coated with a layer of fibrinogen molecules by adsorption from the buffer. Silicon Dioxide 20-26 fibrinogen beta chain Homo sapiens 62-72 16378437-6 2006 The plasma polymer coatings with the greatest protein-repelling properties were the most PEG-like in nature and showed the strongest repulsion in interaction force measurements with the fibrinogen-coated probe. Polymers 11-18 fibrinogen beta chain Homo sapiens 186-196 16378437-6 2006 The plasma polymer coatings with the greatest protein-repelling properties were the most PEG-like in nature and showed the strongest repulsion in interaction force measurements with the fibrinogen-coated probe. Polyethylene Glycols 89-92 fibrinogen beta chain Homo sapiens 186-196 16378437-9 2006 This indicates that the structure of the fibrinogen molecules on the probe is changed from an extended conformation in buffer to a flat conformation in water, with the former state allowing for stronger interaction with the polymer chains on the surface. Water 152-157 fibrinogen beta chain Homo sapiens 41-51 16378437-9 2006 This indicates that the structure of the fibrinogen molecules on the probe is changed from an extended conformation in buffer to a flat conformation in water, with the former state allowing for stronger interaction with the polymer chains on the surface. Polymers 224-231 fibrinogen beta chain Homo sapiens 41-51 16390607-2 2006 Here we aimed to demonstrate that lithium-heparin plasma samples could be used for protein electrophoresis and paraprotein typing without or with ethanol treatment to remove the fibrinogen. Lithium 34-41 fibrinogen beta chain Homo sapiens 178-188 16390607-2 2006 Here we aimed to demonstrate that lithium-heparin plasma samples could be used for protein electrophoresis and paraprotein typing without or with ethanol treatment to remove the fibrinogen. Heparin 42-49 fibrinogen beta chain Homo sapiens 178-188 16390607-8 2006 RESULTS AND CONCLUSIONS: Ethanol treatment significantly but incompletely removed the fibrinogen in lithium-heparin plasma samples and did not affect the integrity of any of the proteins investigated. Ethanol 25-32 fibrinogen beta chain Homo sapiens 86-96 16390607-8 2006 RESULTS AND CONCLUSIONS: Ethanol treatment significantly but incompletely removed the fibrinogen in lithium-heparin plasma samples and did not affect the integrity of any of the proteins investigated. Lithium 100-107 fibrinogen beta chain Homo sapiens 86-96 16390607-9 2006 Even without ethanol treatment, lithium-heparin plasma can be used for protein electrophoresis and paraprotein identification as the instances of interference between fibrinogen and paraproteins was low (2.3%). lithium-heparin 32-47 fibrinogen beta chain Homo sapiens 167-177 17131847-16 2006 The treatment with perindopril is only partially effective in alleviating the procoagulant state, by reducing fibrinogen level in II homozygotes due to its more potent inhibitory action on the RAS in this group. Perindopril 19-30 fibrinogen beta chain Homo sapiens 110-120 16417248-2 2006 A generic route to biocompatible silicone elastomers is described involving high yield surface functionalization of standard silicones with hydrosilanes, hydrosilylation using asymmetric, allyl-, NSC-terminated PEO of narrow molecular weight, and covalent modification in one step with amine-containing biological molecules including oligopeptides (YIGSR, RGDS), proteins (EGF, albumin, fibrinogen, mucin), and glycosaminoglycans (heparin). Silicones 33-41 fibrinogen beta chain Homo sapiens 387-397 16029886-0 2006 Electrochemical processing of fibrinogen modified-graphite surfaces: effect on plasmin generation from adsorbed plasminogen. Graphite 50-58 fibrinogen beta chain Homo sapiens 30-40 16029886-1 2006 With the aim to improve the fibrinolytic properties of carbons by different biological and electrochemical treatments, we modified graphite surfaces by fibrinogen adsorption and subsequent application of various constant potentials before submitting them to plasminogen adsorption. Graphite 131-139 fibrinogen beta chain Homo sapiens 152-162 16607071-4 2006 The odds ratio for myocardial infarction increased progressively across the four quarters of the homocysteine distribution, after adjusting for only age and sex or for the full adjustment (age, sex, smoking, systolic blood pressure, total cholesterol, fibrinogen, C-reactive protein and interleukin-6). Homocysteine 97-109 fibrinogen beta chain Homo sapiens 252-262 16607083-0 2006 Novel fibrinogen mutation (gamma 313 Ser-->Asn) associated with hypofibrinogenemia in two unrelated families. Serine 37-40 fibrinogen beta chain Homo sapiens 6-16 16607083-0 2006 Novel fibrinogen mutation (gamma 313 Ser-->Asn) associated with hypofibrinogenemia in two unrelated families. Asparagine 46-49 fibrinogen beta chain Homo sapiens 6-16 16607083-4 2006 Isolated plasma fibrinogen was studied by sodium dodecyl sulfate electrophoresis and electrospray ionization mass spectrometry in order to detect variant polypeptides. Sodium Dodecyl Sulfate 42-64 fibrinogen beta chain Homo sapiens 16-26 16776642-5 2006 METHODS: Unselected paired samples were used for comparison between the TEST 1 and Sedimatic 100 methods (n=733); fibrinogen was measured in EDTA samples (n=765) using a turbidimetric method. Edetic Acid 141-145 fibrinogen beta chain Homo sapiens 114-124 16192735-4 2006 Those women receiving intranasal estradiol showed a mild increment in plasminogen activator inhibitor-1 (PAI-I) (from 6.8 +/- 3.5 to 9.6 +/- 3.9 U/ml, p < 0.01); however, fibrinogen, factor VII-tissue factor complex (VIIa-rTF), antithrombin III (ATIII), protein C (PC) activity, protein S (PS) activity, plasminogen (PLG), and tissue-type plasminogen activator antigen (t-PA) were unchanged. Estradiol 33-42 fibrinogen beta chain Homo sapiens 174-184 16930084-8 2006 RESULTS: Compared with aspirin-resistant patients, patients who demonstrated effective aspirin inhibition had a significantly lower plasma fibrinogen level (3.3 g/L vs 3.8 g/L; p < 0.05) and significantly lower RBC aggregation values (24.3 vs 28.2; p < 0.01). Aspirin 87-94 fibrinogen beta chain Homo sapiens 139-149 17047615-2 2006 Effect of 10 and 20 mg/day atorvastatin on levels of lipids, C-reactive protein, and fibrinogen in patients with ischemic heart disease and hyperlipidemia]. Atorvastatin 27-39 fibrinogen beta chain Homo sapiens 85-95 16406498-1 2006 Fibrinogen Guarenas is a dysfibrinogenemia with a nonsense mutation at G4731T that causes an Aalpha-chain truncation at Ser 466. Serine 120-123 fibrinogen beta chain Homo sapiens 0-10 16263253-0 2006 Secreted protein acidic and rich in cysteine (SPARC/osteonectin/BM-40) binds to fibrinogen fragments D and E, but not to native fibrinogen. Cysteine 36-44 fibrinogen beta chain Homo sapiens 80-90 16359330-5 2006 FnBPA-promoted platelet activation is mediated by fibrinogen and fibronectin bridges between the A domain and the BCD domains, respectively, to the low affinity form of the integrin GPIIb/IIIa on resting platelets. fnbpa 0-5 fibrinogen beta chain Homo sapiens 50-60 16005496-6 2006 RESULTS: Dexamethasone tended to modestly increase clotting factors levels and fibrinogen without significantly affecting PAI-1, D-dimer or sCD40-ligand. Dexamethasone 9-22 fibrinogen beta chain Homo sapiens 79-89 16406498-6 2006 The binding of albumin to fibrinogen was increased compared to control due to the presence of a free sulfhydryl group because of the missing disulphide bridge between Aalpha-Cys 442-472 in the mutated molecules. disulphide 141-151 fibrinogen beta chain Homo sapiens 26-36 16406498-6 2006 The binding of albumin to fibrinogen was increased compared to control due to the presence of a free sulfhydryl group because of the missing disulphide bridge between Aalpha-Cys 442-472 in the mutated molecules. Cysteine 174-177 fibrinogen beta chain Homo sapiens 26-36 27265009-9 2005 Fibrinogen was only associated with DBP in non-smokers (r= 0.3273, p= 0.0047). Diosmin 36-39 fibrinogen beta chain Homo sapiens 0-10 16499438-5 2006 We have developed a PEGylated fibrin patch for MSC transplantation by modifying fibrinogen (Fgn) with the benzotriazole carbonate derivative of PEG to create secondary crosslinking. Polyethylene Glycols 20-23 fibrinogen beta chain Homo sapiens 80-90 16499438-5 2006 We have developed a PEGylated fibrin patch for MSC transplantation by modifying fibrinogen (Fgn) with the benzotriazole carbonate derivative of PEG to create secondary crosslinking. Polyethylene Glycols 20-23 fibrinogen beta chain Homo sapiens 92-95 16499438-6 2006 In this study, the chemical PEGylation of fibrinogen was verified by both amine group quantification and SDS-PAGE. Amines 74-79 fibrinogen beta chain Homo sapiens 42-52 16499438-6 2006 In this study, the chemical PEGylation of fibrinogen was verified by both amine group quantification and SDS-PAGE. Sodium Dodecyl Sulfate 105-108 fibrinogen beta chain Homo sapiens 42-52 16856769-7 2006 The literature indicates a strong relationship between boiled, unfiltered coffee consumption and elevated cholesterol levels; however, there is a critical gap in the literature regarding the effects of coffee or caffeine consumption on fibrinogen or CRP, which is an independent predictor of CVD risk. Caffeine 212-220 fibrinogen beta chain Homo sapiens 236-246 16363805-0 2005 A cluster of basic amino acid residues in the gamma370-381 sequence of fibrinogen comprises a binding site for platelet integrin alpha(IIb)beta3 (glycoprotein IIb/IIIa). Amino Acids, Basic 13-29 fibrinogen beta chain Homo sapiens 71-81 16363805-9 2005 Confirming the critical roles of the identified residues, abnormal fibrinogen Kaiserslautern, in which gammaLys380 is replaced by Asn, demonstrated delayed clot retraction and impaired alpha(IIb)beta3 binding. gammalys380 103-114 fibrinogen beta chain Homo sapiens 67-77 16363805-9 2005 Confirming the critical roles of the identified residues, abnormal fibrinogen Kaiserslautern, in which gammaLys380 is replaced by Asn, demonstrated delayed clot retraction and impaired alpha(IIb)beta3 binding. Asparagine 130-133 fibrinogen beta chain Homo sapiens 67-77 16363805-10 2005 Also, a mutant recombinant fibrinogen modeled after the naturally occurring variant Osaka V (gammaArg375 --> Gly) showed delayed clot retraction and reduced binding to purified alpha(IIb)beta3. Glycine 112-115 fibrinogen beta chain Homo sapiens 27-37 16138323-4 2005 Even though treatment of fibrinogen adsorption on the samples in advance led to higher induction of blood cell adhesion than those with no fibrinogen adsorption, the polylactide scaffold surface itself induced highest amount of the adhered blood cells in this study judged by analyses of their surface area. poly(lactide) 166-177 fibrinogen beta chain Homo sapiens 25-35 16853918-2 2005 The reversible (switching) behavior of these poly(N-isopropylacrylamide) surfaces has been exemplified by screening the adsorption of fibrinogen and fluorescein isothiocyanate labeled bovine serum albumin proteins by surface plasmon resonance (SPR) and fluorescence microscopy at low and elevated temperatures. poly-N-isopropylacrylamide 45-72 fibrinogen beta chain Homo sapiens 134-144 16378798-9 2005 In contrast, both C-reactive protein and fibrinogen had U-shaped associations with quintiles of creatinine and eGFR, because the inflammatory markers were equivalently elevated in quintiles 1 and 5. Creatinine 96-106 fibrinogen beta chain Homo sapiens 41-51 16364844-2 2005 METHODS: Ten long-term heart transplant recipients were examined with positron emission tomography (PET) to measure myocardial perfusion before and after a single heparin-mediated extracorporeal LDL/fibrinogen precipitation (HELP)-apheresis treatment. Heparin 163-170 fibrinogen beta chain Homo sapiens 199-209 16026826-0 2005 Fibrinogen surface distribution correlates to platelet adhesion pattern on fluorinated surface-modified polyetherurethane. polyetherurethane 104-121 fibrinogen beta chain Homo sapiens 0-10 16300405-0 2005 Interactions of thrombin with fibrinogen adsorbed on methyl-, hydroxyl-, amine-, and carboxyl-terminated self-assembled monolayers. N-methylhydroxylamine 53-78 fibrinogen beta chain Homo sapiens 30-40 16477805-5 2005 The Framingham Study reaffirms the significant linear risk factor trends across fibrinogen tertiles (P< 0.001) for age, body mass index, smoking, diabetes mellitus, total cholesterol, HDL cholesterol, and TG in both sexes. Cholesterol 174-185 fibrinogen beta chain Homo sapiens 80-90 16477805-5 2005 The Framingham Study reaffirms the significant linear risk factor trends across fibrinogen tertiles (P< 0.001) for age, body mass index, smoking, diabetes mellitus, total cholesterol, HDL cholesterol, and TG in both sexes. Cholesterol 191-202 fibrinogen beta chain Homo sapiens 80-90 16477805-5 2005 The Framingham Study reaffirms the significant linear risk factor trends across fibrinogen tertiles (P< 0.001) for age, body mass index, smoking, diabetes mellitus, total cholesterol, HDL cholesterol, and TG in both sexes. Thioguanine 208-210 fibrinogen beta chain Homo sapiens 80-90 16477805-12 2005 The correlation between fibrinogen and LDL cholesterol suggests that lipid-imposed CVD risk is mediated partly through fibrinogen. Cholesterol 43-54 fibrinogen beta chain Homo sapiens 24-34 16477805-12 2005 The correlation between fibrinogen and LDL cholesterol suggests that lipid-imposed CVD risk is mediated partly through fibrinogen. Cholesterol 43-54 fibrinogen beta chain Homo sapiens 119-129 16477807-6 2005 The stearic acid-rich test fat increased plasma fibrinogen concentrations slightly compared with the myristic-lauric acid diet (P < 0.01). stearic acid 4-16 fibrinogen beta chain Homo sapiens 48-58 16386185-12 2005 (3) High blood sugar and fibrinogen levels may be potential risk factors, in particular, a high fibrinogen level implies a poor prognosis. Sugars 15-20 fibrinogen beta chain Homo sapiens 96-106 16300405-0 2005 Interactions of thrombin with fibrinogen adsorbed on methyl-, hydroxyl-, amine-, and carboxyl-terminated self-assembled monolayers. , and carboxyl 79-93 fibrinogen beta chain Homo sapiens 30-40 16300405-4 2005 Fibrinogen adsorbed on negatively charged surfaces (carboxyl-terminated self-assembled monolayers) released a smaller amount of fibrinopeptides, at a reduced rate relative to those of hydrophobic, hydrophilic, and positively charged surfaces (methyl-, hydroxyl-, and amine-terminated self-assembled monolayers, respectively). methyl-, hydroxyl-, and amine 243-272 fibrinogen beta chain Homo sapiens 0-10 16853860-1 2005 The adsorption behavior of fibrinogen to two biomedical polyurethanes and a perfluorinated polymer has been investigated. Polyurethanes 56-69 fibrinogen beta chain Homo sapiens 27-37 16853860-1 2005 The adsorption behavior of fibrinogen to two biomedical polyurethanes and a perfluorinated polymer has been investigated. Polymers 91-98 fibrinogen beta chain Homo sapiens 27-37 16853860-4 2005 Amide I signals from SFG demonstrate that fibrinogen has post-adsorption conformational changes that are dependent upon the polymer surface properties. Amides 0-5 fibrinogen beta chain Homo sapiens 42-52 16853860-4 2005 Amide I signals from SFG demonstrate that fibrinogen has post-adsorption conformational changes that are dependent upon the polymer surface properties. Polymers 124-131 fibrinogen beta chain Homo sapiens 42-52 16853860-5 2005 For example, strong attenuation of the amide I and N-H stretching signals with increasing residence time was observed for fibrinogen adsorbed to poly(ether urethane) but not for the other two polymers. Amides 39-44 fibrinogen beta chain Homo sapiens 122-132 16853860-5 2005 For example, strong attenuation of the amide I and N-H stretching signals with increasing residence time was observed for fibrinogen adsorbed to poly(ether urethane) but not for the other two polymers. polyetherurethane 145-164 fibrinogen beta chain Homo sapiens 122-132 16314788-5 2005 Fibrinogen and CRP levels increased in these patients after sirolimus introduction. Sirolimus 60-69 fibrinogen beta chain Homo sapiens 0-10 15998829-2 2005 Exposure of A-knobs in desA-fibrin or its fragment from the central part of the molecule (N-terminal disulphide knot, NDSK) resulted in strong interactions with fibrinogen or fragment D (containing only a- and b-holes), producing a binding strength of approximately 125 to 130 pN. disulphide 101-111 fibrinogen beta chain Homo sapiens 161-171 16169302-3 2005 AIMS: To examine the effect of topical nicotine on plasma fibrinogen and any relationship between fibrinogen and ulcerative colitis disease activity. Nicotine 39-47 fibrinogen beta chain Homo sapiens 58-68 16169302-8 2005 : At 6 weeks median plasma fibrinogen was 3.30 g/l on nicotine compared to 3.05 g/l on placebo, P = 0.90 when adjusted for baseline values. Nicotine 54-62 fibrinogen beta chain Homo sapiens 27-37 16358236-7 2005 On multivariate Cox"s regression analyses, including traditional risk factors and history of previous CV events, Fib (hazard ratio (HR) associated with 100 mg/dL increase in plasma Fib 1.29 95% confidence interval (CI) 1.03-1.63 (p=0.03)) and calcium x phosphate product (HR associated with a 5 mg2/dL2 increase 1.25 95% CI 1.05-1.49 (p=0.01)) emerged as independent CV event predictors. Calcium 243-250 fibrinogen beta chain Homo sapiens 113-116 16358236-7 2005 On multivariate Cox"s regression analyses, including traditional risk factors and history of previous CV events, Fib (hazard ratio (HR) associated with 100 mg/dL increase in plasma Fib 1.29 95% confidence interval (CI) 1.03-1.63 (p=0.03)) and calcium x phosphate product (HR associated with a 5 mg2/dL2 increase 1.25 95% CI 1.05-1.49 (p=0.01)) emerged as independent CV event predictors. Phosphates 253-262 fibrinogen beta chain Homo sapiens 113-116 16386543-6 2005 Multivariate evaluation showed that creatinine clearance, plasma intraerythrocyte folate and vitamin B(12) levels, and plasma fibrinogen levels were independently associated with Hcy levels. Homocysteine 179-182 fibrinogen beta chain Homo sapiens 126-136 16229537-0 2005 Displacement of fibrinogen from the air/aqueous interface by dilauroylphosphatidylcholine lipid. dilauroylphosphatidylcholine lipid 61-95 fibrinogen beta chain Homo sapiens 16-26 16229537-3 2005 By having a molecular adsorption mechanism, as compared to a particulate adsorption mechanism of other longer chain lipids, dilauroylphosphatidylcholine (DLPC) lipid can expel FB from the air/aqueous interface at 25 degrees C, in water or in phosphate-buffered saline, as proven by tensiometry (also at 37 degrees C), ellipsometry, and infrared reflection-absorption spectroscopy. 1,2-dilauroylphosphatidylcholine 124-152 fibrinogen beta chain Homo sapiens 176-178 16229537-3 2005 By having a molecular adsorption mechanism, as compared to a particulate adsorption mechanism of other longer chain lipids, dilauroylphosphatidylcholine (DLPC) lipid can expel FB from the air/aqueous interface at 25 degrees C, in water or in phosphate-buffered saline, as proven by tensiometry (also at 37 degrees C), ellipsometry, and infrared reflection-absorption spectroscopy. 1,2-dilauroylphosphatidylcholine 154-158 fibrinogen beta chain Homo sapiens 176-178 15967604-6 2005 The two treatments had differential effects on lipids and fibrinogen levels; raloxifene had more favourable effects on serum HDL, the LDL/HDL ratio, and plasma fibrinogen. Raloxifene Hydrochloride 77-87 fibrinogen beta chain Homo sapiens 160-170 16202731-6 2005 Compared with placebo, raloxifene 60 mg decreased total protein S (-8.2%, P = .009) after 4 weeks and antithrombin (-6.0%, P = .034) and fibrinogen (-18.1%, P = .007) after 12 weeks. Raloxifene Hydrochloride 23-33 fibrinogen beta chain Homo sapiens 137-147 16202731-7 2005 CONCLUSION: HMR 3339 and raloxifene decreased fibrinogen levels. Raloxifene Hydrochloride 25-35 fibrinogen beta chain Homo sapiens 46-56 16123330-1 2005 OBJECTIVE: The purpose of this study was to investigate the receptor requirements for enhanced IL-1beta-induced secretion of nitric oxide (NO) by endothelial cells (ECs) in the presence of fibrinogen. Nitric Oxide 125-137 fibrinogen beta chain Homo sapiens 189-199 15958239-5 2005 Layers of hydroxyl-terminated PEO of MW 600 formed under these low solubility conditions showed almost complete suppression (versus controls) of the Vroman effect, with 20+/-1 ng/cm2 adsorbed fibrinogen at the Vroman peak and 6.7+/-0.6 ng/cm2 at higher plasma concentration. Hydroxyl Radical 10-18 fibrinogen beta chain Homo sapiens 192-202 16198619-5 2005 Further tangible evidence of a reduction by TZDs of systemic inflammation in patients with the classical metabolic syndrome stems from falls in the white blood cell count, P-selectin-positive platelets and in the acute-phase inflammatory proteins, C-reactive protein, serum amyloid A and fibrinogen. tzds 44-48 fibrinogen beta chain Homo sapiens 288-298 16034363-10 2005 After 2 h, 13C- and 15N-enrichment of fibrinogen amounted to 70 and 90 ppm excess, respectively. 13c 11-14 fibrinogen beta chain Homo sapiens 38-48 16034363-10 2005 After 2 h, 13C- and 15N-enrichment of fibrinogen amounted to 70 and 90 ppm excess, respectively. 15n 20-23 fibrinogen beta chain Homo sapiens 38-48 16125536-9 2005 Homocysteine levels were not affected but plasma fibrinogen presented a significant increase (303.5+/-75.1 to 387.5+/-70.4 mg/dL, P<.01) with rosiglitazone. Rosiglitazone 145-158 fibrinogen beta chain Homo sapiens 49-59 16037938-0 2005 The role of adsorbed fibrinogen in platelet adhesion to polyurethane surfaces: a comparison of surface hydrophobicity, protein adsorption, monoclonal antibody binding, and platelet adhesion. Polyurethanes 56-68 fibrinogen beta chain Homo sapiens 21-31 16095459-7 2005 Supplementation with FI, but not FIIa or FXIIIa, resulted in 0.9% NaCl-diluted thrombelastographic variable values not different from those of undiluted samples. Sodium Chloride 66-70 fibrinogen beta chain Homo sapiens 21-23 16095459-8 2005 FI supplementation of HES 450, HES 220, HES 130 and albumin-diluted samples only partially restored alpha, A and G-values compared to undiluted samples. Hydroxyethyl Starch Derivatives 22-25 fibrinogen beta chain Homo sapiens 0-2 16052524-5 2005 We showed that fibroblast adhesion to collagen, fibronectin, and fibrinogen were inhibited by EGCG. epigallocatechin gallate 94-98 fibrinogen beta chain Homo sapiens 65-75 16052524-6 2005 One of the possible mechanisms is binding of EGCG to fibronectin and fibrinogen but not to collagen. epigallocatechin gallate 45-49 fibrinogen beta chain Homo sapiens 69-79 15961109-6 2005 NIHSS levels were positively correlated with CRP and fibrinogen at all time points. nihss 0-5 fibrinogen beta chain Homo sapiens 53-63 16307156-9 2005 In hypertensive patients, TC (r = 0.24; p < 0.01) and LDL-C (r = 0.20; p < 0.05) were positively correlated to plasma fibrinogen. Technetium 26-28 fibrinogen beta chain Homo sapiens 124-134 16350383-15 2005 Novel hyaluronan-based heparin-bonded circuits reduce platelet adhesion-aggregation and protein adsorption and provide better perioperative clinical parameters through platelet, albumin, and fibrinogen-sparing effects. Hyaluronic Acid 6-16 fibrinogen beta chain Homo sapiens 191-201 16350383-15 2005 Novel hyaluronan-based heparin-bonded circuits reduce platelet adhesion-aggregation and protein adsorption and provide better perioperative clinical parameters through platelet, albumin, and fibrinogen-sparing effects. Heparin 23-30 fibrinogen beta chain Homo sapiens 191-201 16438853-10 2005 There were positive correlations of fibrinogen level with tumor makers CEA, CA242 and TPS, but not with CA19-9 and CA72-4. ca242 76-81 fibrinogen beta chain Homo sapiens 36-46 16138073-3 2005 SUMMARY OF BACKGROUND DATA: Preliminary prospective, randomized double-blind and analysis of same-day anterior spinal fusion (ASF), fibrinogen, and posterior spinal fusion (PSF) studies have demonstrated Amicar to be effective in idiopathic scoliosis surgery. Aminocaproic Acid 204-210 fibrinogen beta chain Homo sapiens 132-142 16102057-1 2005 Fibrinogen molecules are comprised of two sets of disulfide-bridged Aalpha-, Bbeta-, and gamma-chains. Disulfides 50-59 fibrinogen beta chain Homo sapiens 0-10 15769543-6 2005 Dextran-coated NPs adsorbed ApoA-I and fibrinogen from plasma. Dextrans 0-7 fibrinogen beta chain Homo sapiens 39-49 16044034-3 2005 Evidence suggests that polyamines may interact with the fibrinogen receptor (GP IIb/IIIa), interfering with platelet-platelet attachment. Polyamines 23-33 fibrinogen beta chain Homo sapiens 56-66 16044034-10 2005 It is concluded that the final step in aggregation, common to all agonists, ie, fibrinogen binding to GP IIb/IIIa, is inhibited by spermine through inhibition of the agonist-induced activation of GP IIb/IIIa that precedes fibrinogen-ligand binding. Spermine 131-139 fibrinogen beta chain Homo sapiens 80-90 16044034-10 2005 It is concluded that the final step in aggregation, common to all agonists, ie, fibrinogen binding to GP IIb/IIIa, is inhibited by spermine through inhibition of the agonist-induced activation of GP IIb/IIIa that precedes fibrinogen-ligand binding. Spermine 131-139 fibrinogen beta chain Homo sapiens 222-232 15978785-0 2005 Adsorption of fibrinogen on tantalum oxide, titanium oxide and gold studied by the QCM-D technique. tantalum oxide 28-42 fibrinogen beta chain Homo sapiens 14-24 16808312-10 2005 In conclusion, therapy with hypolipemic diet and simvastatin already after four weeks decreased plasma lipids and fibrinogen levels and improved the course of angina pectoris and exercise stress test, what suggested its effectiveness not only as the treatment improving atherosclerosis risk factors, but also with prompt and clinical important effect ameliorating the handicapped coronary reserve. Simvastatin 49-60 fibrinogen beta chain Homo sapiens 114-124 15978785-0 2005 Adsorption of fibrinogen on tantalum oxide, titanium oxide and gold studied by the QCM-D technique. titanium dioxide 44-58 fibrinogen beta chain Homo sapiens 14-24 15978785-1 2005 The adsorption of human fibrinogen on tantalum oxide, titanium oxide and gold surfaces has been studied by quartz crystal microbalance with dissipation (QCM-D) at 37 degrees C. Two different protein concentrations have been used, one close to physiological concentration (1 mg/ml) and one significantly lower (0.033 mg/ml). tantalum oxide 38-52 fibrinogen beta chain Homo sapiens 24-34 15978785-1 2005 The adsorption of human fibrinogen on tantalum oxide, titanium oxide and gold surfaces has been studied by quartz crystal microbalance with dissipation (QCM-D) at 37 degrees C. Two different protein concentrations have been used, one close to physiological concentration (1 mg/ml) and one significantly lower (0.033 mg/ml). titanium dioxide 54-68 fibrinogen beta chain Homo sapiens 24-34 15978785-5 2005 The fibrinogen layer on gold and tantalum oxide is found to have the same viscoelastic properties, which are different from those found for the fibrinogen layer adsorbed on titanium oxide. titanium dioxide 173-187 fibrinogen beta chain Homo sapiens 144-154 16097942-9 2005 Aggregation induced by CRC54 in the presence of fibrinogen and vWF was only partially suppressed by prostaglandin E1, an inhibitor of platelet activation, and was associated with serotonin release from platelet granules only when Ca2+ concentration was decreased from 1 mM (physiological level) to 0.1 mM. Alprostadil 100-116 fibrinogen beta chain Homo sapiens 48-58 16162440-7 2005 The much larger improvement of FMD due to ciprofibrate therapy was accompanied by significant reductions of cholesterol (by 14.4%), fibrinogen, IL-1alpha, and sICAM levels and by significant increase of high-density lipoprotein (HDL) cholesterol concentration, but the change in FMD correlated only with the reduction of the cholesterol level. ciprofibrate 42-54 fibrinogen beta chain Homo sapiens 132-142 15837518-1 2005 Fibrinogen is a large, complex, fibrous glycoprotein with three pairs of polypeptide chains linked together by 29 disulfide bonds. Disulfides 114-123 fibrinogen beta chain Homo sapiens 0-10 15952850-0 2005 Adsorption of fibrinogen and lysozyme on silicon grafted with poly(2-methacryloyloxyethyl phosphorylcholine) via surface-initiated atom transfer radical polymerization. poly(2-methacryloyloxyethyl-phosphorylcholine) 62-107 fibrinogen beta chain Homo sapiens 14-24 15952850-4 2005 The effect of poly(MPC) chain length on fibrinogen and lysozyme adsorption was studied in TBS buffer at pH 7.4. poly(mpc) 14-23 fibrinogen beta chain Homo sapiens 40-50 15924485-5 2005 The QCM-D was also employed to quantify the adsorption of human fibrinogen, a protein important in thrombus formation, onto the IPNs. ipns 128-132 fibrinogen beta chain Homo sapiens 64-74 15924485-6 2005 Fibrinogen adsorption studies demonstrated the sensitivity of the QCM-D, as well as confirmed the nonfouling nature of the IPN surface, where less than 5 ng/cm2 of fibrinogen was adsorbed. ipn 123-126 fibrinogen beta chain Homo sapiens 0-10 15920062-6 2005 Fenofibrate significantly improved percent flow-mediated dilator response to hyperemia by 48 +/- 5% (P < 0.001) and lowered plasma levels of high-sensitivity C-reactive protein (hsCRP) relative to baseline measurements from 0.80 to 0.70 mg/l (P = 0.001) and fibrinogen levels by 16 +/- 3% (P < 0.001). Fenofibrate 0-11 fibrinogen beta chain Homo sapiens 261-271 16142016-5 2005 Furthermore, repaglinide administration resulted in a significant decrease in fasting plasma free fatty acids, fibrinogen, thrombin-antithrombin complex and reaction product of malondialdehyde with thiobarbituric acid (TBARS) levels, in absence of significant difference in fasting plasma insulin levels. repaglinide 13-24 fibrinogen beta chain Homo sapiens 111-121 16142016-8 2005 At time 120" of meal test, repaglinide vs glimepiride administration was associated with a significant decline in plasma triglycerides, free fatty acids, fibrinogen, Plasminogen Activator Inhibitor-1, plasmin-alpha(2)-antiplasmin complex, thrombin-antithrombin complex, TBARS levels and increase in plasma HDL-cholesterol levels. repaglinide 27-38 fibrinogen beta chain Homo sapiens 154-164 16142016-8 2005 At time 120" of meal test, repaglinide vs glimepiride administration was associated with a significant decline in plasma triglycerides, free fatty acids, fibrinogen, Plasminogen Activator Inhibitor-1, plasmin-alpha(2)-antiplasmin complex, thrombin-antithrombin complex, TBARS levels and increase in plasma HDL-cholesterol levels. glimepiride 42-53 fibrinogen beta chain Homo sapiens 154-164 16123850-6 2005 RESULTS: Fenofibrate decreased plasma fibrinogen level by 41% (from 3.9+/-0.9 mg/dl to 2.3+/-0.48 mg/dl, p<0.0001) and hs-CRP level by 71% (from 1.28 mg/dl to 0.36 mg/dl; p<0.0001). Fenofibrate 9-20 fibrinogen beta chain Homo sapiens 38-48 16060980-5 2005 Using laser scanning confocal microscopy of clots formed from fluorescein-labeled fibrinogen, we investigated what effect binding of fibrin to the endothelial surface has on clot structure and resistance to lysis. Fluorescein 62-73 fibrinogen beta chain Homo sapiens 82-92 15893222-0 2005 In situ conformational analysis of fibrinogen adsorbed on Si surfaces. Silicon 58-60 fibrinogen beta chain Homo sapiens 35-45 16257350-11 2005 Alcohol intake-related reduced risk for restriction was associated with lower risk of CHF, diabetes, obesity, and lower markers of inflammation (white blood cell, fibrinogen, and C-reactive protein) consistent with less lung congestion, external restriction, and/or lung inflammation. Alcohols 0-7 fibrinogen beta chain Homo sapiens 163-173 16104396-0 2005 [Interrelationship between platelet nitric oxide production and plasma fibrinogen level in emergencies]. Nitric Oxide 36-48 fibrinogen beta chain Homo sapiens 71-81 16104396-2 2005 There is correlation between absolute platelets nitric oxide production and fibrinogen plasma level in these patients. Nitric Oxide 48-60 fibrinogen beta chain Homo sapiens 76-86 16104396-4 2005 Irrespectively to etiology and danger of disease, reliable correlation between absolute platelets nitric oxide production and fibrinogen plasma level of these patients is established. Nitric Oxide 98-110 fibrinogen beta chain Homo sapiens 126-136 15911896-6 2005 RESULTS: Social integration was significantly associated with elevated concentrations of fibrinogen (>336 mg/dL) in men after adjusting for smoking, alcohol consumption, physical activity, body mass index, comorbidity, physical functioning, depression, age, race, and education (odds ratio [OR] = 2.29, 95% confidence interval [CI] = 1.07-4.89, p = .03 for having elevated fibrinogen in the least integrated quartile versus the most integrated quartile). Alcohols 152-159 fibrinogen beta chain Homo sapiens 89-99 15632207-4 2005 DNA sequence analysis of the fibrinogen genes A, B, and G revealed a T>C transition in exon 9 resulting in a serine-to-proline substitution near the gamma chain C-terminus (S378P). Serine 112-118 fibrinogen beta chain Homo sapiens 29-39 15632207-4 2005 DNA sequence analysis of the fibrinogen genes A, B, and G revealed a T>C transition in exon 9 resulting in a serine-to-proline substitution near the gamma chain C-terminus (S378P). Proline 122-129 fibrinogen beta chain Homo sapiens 29-39 15821821-9 2005 Fibrinogen was positively associated with body mass index (BMI), systolic and diastolic blood pressure, total cholesterol (TC), uric acid, vWF, and insulin resistance. Cholesterol 110-121 fibrinogen beta chain Homo sapiens 0-10 15821821-9 2005 Fibrinogen was positively associated with body mass index (BMI), systolic and diastolic blood pressure, total cholesterol (TC), uric acid, vWF, and insulin resistance. Technetium 123-125 fibrinogen beta chain Homo sapiens 0-10 15821821-9 2005 Fibrinogen was positively associated with body mass index (BMI), systolic and diastolic blood pressure, total cholesterol (TC), uric acid, vWF, and insulin resistance. Uric Acid 128-137 fibrinogen beta chain Homo sapiens 0-10 15809497-6 2005 Total alcohol intake was significantly related with HDL cholesterol and fibrinogen improvements in both genders. Alcohols 6-13 fibrinogen beta chain Homo sapiens 72-82 15608046-13 2005 CONCLUSION: Coagulopathy induced by haemodilution with either HES 200/0.5, HES 130/0.4, and dextran 70 may be improved by fibrinogen supplementation. Hydroxyethyl Starch Derivatives 62-65 fibrinogen beta chain Homo sapiens 122-132 15608046-13 2005 CONCLUSION: Coagulopathy induced by haemodilution with either HES 200/0.5, HES 130/0.4, and dextran 70 may be improved by fibrinogen supplementation. Hydroxyethyl Starch Derivatives 75-78 fibrinogen beta chain Homo sapiens 122-132 15608046-13 2005 CONCLUSION: Coagulopathy induced by haemodilution with either HES 200/0.5, HES 130/0.4, and dextran 70 may be improved by fibrinogen supplementation. Dextrans 92-99 fibrinogen beta chain Homo sapiens 122-132 15666410-10 2005 Additionally, protein conformation and assembly orientation on these surfaces were documented where fibrinogen on HOPG formed a network-like structure, whereas fibrinogen on mica was more random. mica 174-178 fibrinogen beta chain Homo sapiens 160-170 15604525-0 2005 Activation of the nuclear receptor FXR induces fibrinogen expression: a new role for bile acid signaling. Bile Acids and Salts 85-94 fibrinogen beta chain Homo sapiens 47-57 15772566-7 2005 After genistein-treatment, fibrinogen decreased (genistein = 3.18 +/- 0.12 g/L; placebo = 3.83 +/- 0.04 g/L; P < 0.001) with respect to placebo. Genistein 6-15 fibrinogen beta chain Homo sapiens 27-37 15772566-7 2005 After genistein-treatment, fibrinogen decreased (genistein = 3.18 +/- 0.12 g/L; placebo = 3.83 +/- 0.04 g/L; P < 0.001) with respect to placebo. Genistein 49-58 fibrinogen beta chain Homo sapiens 27-37 15609386-7 2005 RESULTS: Within 12 h of the loading dose, platelet activation in the clopidogrel group had decreased (P-selectin by 27.3 per cent, P = 0.017; fibrinogen binding by 34.7 per cent, P = 0.024; stimulated fibrinogen binding by 49.2 per cent, P < 0.001). Clopidogrel 69-80 fibrinogen beta chain Homo sapiens 142-152 15609386-7 2005 RESULTS: Within 12 h of the loading dose, platelet activation in the clopidogrel group had decreased (P-selectin by 27.3 per cent, P = 0.017; fibrinogen binding by 34.7 per cent, P = 0.024; stimulated fibrinogen binding by 49.2 per cent, P < 0.001). Clopidogrel 69-80 fibrinogen beta chain Homo sapiens 201-211 15609386-9 2005 Platelet function in the clopidogrel group was significantly suppressed compared with baseline at 1 h, 24 h and 30 days after endovascular intervention (stimulated fibrinogen binding by 53.9, 51.7 and 57.2 per cent respectively; all P < 0.001). Clopidogrel 25-36 fibrinogen beta chain Homo sapiens 164-174 15750272-6 2005 After steroid therapy was restarted, there were improvements in her audibility, radial arterial pulsation, and levels of inflammatory markers (erythrocyte sedimentation rate, C-reactive protein, and gamma-globulin), fibrinogen, interleukin-6, and RANTES (regulated on activation, normal T cell expressed and secreted). Steroids 6-13 fibrinogen beta chain Homo sapiens 216-226 15853141-6 2005 Furthermore, all the PEG films were evaluated for their ability to control biofouling using albumin and fibrinogen as the model proteins. Polyethylene Glycols 21-24 fibrinogen beta chain Homo sapiens 104-114 15690309-3 2005 In multiple linear regression analyses concerning control subjects, family disposition, social class, a score based on serum triglyceride and high-density lipoprotein (HDL) cholesterol concentrations, and fasting capillary blood glucose concentration were significantly associated with plasma fibrinogen concentration (P < .00005, R2 = 0.81). Triglycerides 125-137 fibrinogen beta chain Homo sapiens 293-303 15690309-3 2005 In multiple linear regression analyses concerning control subjects, family disposition, social class, a score based on serum triglyceride and high-density lipoprotein (HDL) cholesterol concentrations, and fasting capillary blood glucose concentration were significantly associated with plasma fibrinogen concentration (P < .00005, R2 = 0.81). Cholesterol 173-184 fibrinogen beta chain Homo sapiens 293-303 15690309-3 2005 In multiple linear regression analyses concerning control subjects, family disposition, social class, a score based on serum triglyceride and high-density lipoprotein (HDL) cholesterol concentrations, and fasting capillary blood glucose concentration were significantly associated with plasma fibrinogen concentration (P < .00005, R2 = 0.81). Glucose 229-236 fibrinogen beta chain Homo sapiens 293-303 15711748-0 2005 CD63 modulates spreading and tyrosine phosphorylation of platelets on immobilized fibrinogen. Tyrosine 29-37 fibrinogen beta chain Homo sapiens 82-92 15828907-11 2005 Thanks to it"s effect of antagonizing hemorheologic disorders of the ocular microcirculation, fibrinogen/LDL-apheresis seems to be an efficacious treatment of NAION. naion 159-164 fibrinogen beta chain Homo sapiens 94-104 15869595-8 2005 CONCLUSION: We conclude that a region adjacent to Bbeta15Gly plays important roles in lateral aggregation not only in desA fibrin polymerization, but also in desAB fibrin polymerization, and we speculate that the marked functional differences between Bbeta15A and Bbeta15C fibrinogens in FPB release and fibrin polymerization might not only be due to the presence of a substituted cysteine residue in Bbeta15C fibrinogen, but also to the existence of disulfide-bonded forms. bbeta15gly 50-60 fibrinogen beta chain Homo sapiens 273-283 15877299-13 2005 There was no significant change in fibrinogen levels during the treatment of pravastatin and atorvastatin ( P > .05), but in fenofibrate group, fibrinogen levels were significantly decreased ( P < .05). Fenofibrate 128-139 fibrinogen beta chain Homo sapiens 147-157 15877299-15 2005 Only fenofibrate has significant beneficial effects on the fibrinogen levels. Fenofibrate 5-16 fibrinogen beta chain Homo sapiens 59-69 15886810-4 2005 When blood samples were pre-incubated in the presence of 2%, 5%, and 10% of CM without stirring, both ioxaglate and iodixanol had little effect on unstimulated samples, but dose-independently decreased 1 microM ADP-induced platelet P-selectin expression and fibrinogen binding, and thus platelet-leukocyte aggregate formation. Ioxaglic Acid 102-111 fibrinogen beta chain Homo sapiens 258-268 15886810-4 2005 When blood samples were pre-incubated in the presence of 2%, 5%, and 10% of CM without stirring, both ioxaglate and iodixanol had little effect on unstimulated samples, but dose-independently decreased 1 microM ADP-induced platelet P-selectin expression and fibrinogen binding, and thus platelet-leukocyte aggregate formation. iodixanol 116-125 fibrinogen beta chain Homo sapiens 258-268 15966267-9 2005 Pentoxifyllin is considered to lower pathologically increased levels of fibrinogen. Pentoxifylline 0-13 fibrinogen beta chain Homo sapiens 72-82 15721922-6 2005 The electrostatic influence on fibrinogen adsorption on the gold-coated silicon wafer was weak, so the hydrophobic interaction should be the major affinity. Silicon 72-79 fibrinogen beta chain Homo sapiens 31-41 15804733-8 2005 Raloxifene decreased the levels of fibrinogen, from 354.7 to 302.0 g/l (p = 0.009) and the levels of antithrombin III, from 102.4 to 98.5% (p = 0.039). Raloxifene Hydrochloride 0-10 fibrinogen beta chain Homo sapiens 35-45 15837518-3 2005 Both strongly and weakly bound calcium ions are important for maintenance of fibrinogen"s structure and functions. Calcium 31-38 fibrinogen beta chain Homo sapiens 77-87 15796705-8 2005 Finally, these microfluidic techniques were combined with fluorescence microscopy and nonlinear optical spectroscopy to elucidate the mechanism of fibrinogen displacement from silica surfaces. Silicon Dioxide 176-182 fibrinogen beta chain Homo sapiens 147-157 15514209-5 2005 Associations between selected polymorphisms and the platelet response to ADP (0.1, 1.0, and 10 micromol/L), assessed by whole blood flow cytometric measurement of fibrinogen binding to activated glycoprotein IIb-IIIa, were then determined in 200 subjects. Adenosine Diphosphate 73-76 fibrinogen beta chain Homo sapiens 163-173 15638502-0 2005 In vitro measurement of conformational stability of fibrinogen adsorbed on siloxane. Siloxanes 75-83 fibrinogen beta chain Homo sapiens 52-62 15638502-2 2005 The fact that the decrease in fluorescence intensity of siloxane-treated Fbg was accompanied by red shift in the maximum wavelength indicated that denaturation of Fbg had taken place. Siloxanes 56-64 fibrinogen beta chain Homo sapiens 73-76 15638502-2 2005 The fact that the decrease in fluorescence intensity of siloxane-treated Fbg was accompanied by red shift in the maximum wavelength indicated that denaturation of Fbg had taken place. Siloxanes 56-64 fibrinogen beta chain Homo sapiens 163-166 15638502-3 2005 The differences (the decrease in peak height and the shift in retention time) in chromatograms between control Fbg and siloxane-treated Fbg indicated the adsorption process of Fbg on the surface of siloxanes. Siloxanes 119-127 fibrinogen beta chain Homo sapiens 136-139 15638502-3 2005 The differences (the decrease in peak height and the shift in retention time) in chromatograms between control Fbg and siloxane-treated Fbg indicated the adsorption process of Fbg on the surface of siloxanes. Siloxanes 119-127 fibrinogen beta chain Homo sapiens 136-139 15638502-3 2005 The differences (the decrease in peak height and the shift in retention time) in chromatograms between control Fbg and siloxane-treated Fbg indicated the adsorption process of Fbg on the surface of siloxanes. Siloxanes 198-207 fibrinogen beta chain Homo sapiens 111-114 15638502-3 2005 The differences (the decrease in peak height and the shift in retention time) in chromatograms between control Fbg and siloxane-treated Fbg indicated the adsorption process of Fbg on the surface of siloxanes. Siloxanes 198-207 fibrinogen beta chain Homo sapiens 136-139 15638502-3 2005 The differences (the decrease in peak height and the shift in retention time) in chromatograms between control Fbg and siloxane-treated Fbg indicated the adsorption process of Fbg on the surface of siloxanes. Siloxanes 198-207 fibrinogen beta chain Homo sapiens 136-139 15638502-4 2005 Incubating hexamethyldisiloxane with Fbg at L(2)-to-Fbg ratios >300 for 20 h yielded white and mould-like precipitates of Fbg. hexamethyldisiloxane 11-31 fibrinogen beta chain Homo sapiens 37-40 15638502-4 2005 Incubating hexamethyldisiloxane with Fbg at L(2)-to-Fbg ratios >300 for 20 h yielded white and mould-like precipitates of Fbg. hexamethyldisiloxane 11-31 fibrinogen beta chain Homo sapiens 52-55 15638502-4 2005 Incubating hexamethyldisiloxane with Fbg at L(2)-to-Fbg ratios >300 for 20 h yielded white and mould-like precipitates of Fbg. hexamethyldisiloxane 11-31 fibrinogen beta chain Homo sapiens 52-55 15638502-5 2005 The same phenomenon demonstrating massive denaturation and aggregation was observed for a greater than 500-fold excess of D(3) with respect to Fbg after 20 h of incubation. Cholecalciferol 122-126 fibrinogen beta chain Homo sapiens 143-146 16015032-11 2005 Plasma fibrinogen was correlated with nocturnal minimal oxygen saturation (r=-0275, p=0.0036) and AHI (r=0.297, p=0.001). Oxygen 56-62 fibrinogen beta chain Homo sapiens 7-17 15666410-4 2005 These methods were developed using the plasma protein fibrinogen in a phosphate-buffered saline solution on grade IV muscovite mica and highly ordered pyrolytic graphite (HOPG) substrates. Phosphate-Buffered Saline 70-95 fibrinogen beta chain Homo sapiens 54-64 15782857-13 2005 Heparin in the interstitial tissue of the wound surface blocks the conversion of fibrinogen to fibrin. Heparin 0-7 fibrinogen beta chain Homo sapiens 81-91 17532716-8 2005 RESULTS: Rice policosanol significantly reduced plasma total cholesterol from 7.37 +/- 1.42 mmol/L to 6.99 +/- 1.33 mmol/L (p = 0.007) and increased Apo AI from 1.49 +/- 0.39 mmol/L to 1.58 +/- 0.38 mmol/L (p = 0.037) but did not change plasma triglycerides, HDL, HDL2, HDL3 and LDL cholesterol, ox-LDL, Lp(a), Apo B, fibrinogen, homocysteine or CRP levels. policosanol 14-25 fibrinogen beta chain Homo sapiens 318-328 16331433-7 2005 Fibrinogen and white blood cell count also were associated positively with estrone, androstenedione, and testosterone (and fibrinogen also with dehydroepiandrosterone sulfate). Estrone 75-82 fibrinogen beta chain Homo sapiens 0-10 16433252-11 2005 In addition, testosterone levels showed positive correlations with albumin (r = 0.690, p = 0.019) and negative correlations with uric acid (r = -0.630, p < 0.001), HsCRP (r = -0.449, p = 0.003), fibrinogen (r = -0.508, p = 0.001), and white blood cells (r = -0.433, p = 0.005). Testosterone 13-25 fibrinogen beta chain Homo sapiens 198-208 16331433-7 2005 Fibrinogen and white blood cell count also were associated positively with estrone, androstenedione, and testosterone (and fibrinogen also with dehydroepiandrosterone sulfate). Androstenedione 84-99 fibrinogen beta chain Homo sapiens 0-10 16331433-7 2005 Fibrinogen and white blood cell count also were associated positively with estrone, androstenedione, and testosterone (and fibrinogen also with dehydroepiandrosterone sulfate). Testosterone 105-117 fibrinogen beta chain Homo sapiens 0-10 16331433-7 2005 Fibrinogen and white blood cell count also were associated positively with estrone, androstenedione, and testosterone (and fibrinogen also with dehydroepiandrosterone sulfate). Dehydroepiandrosterone Sulfate 144-174 fibrinogen beta chain Homo sapiens 0-10 16331433-7 2005 Fibrinogen and white blood cell count also were associated positively with estrone, androstenedione, and testosterone (and fibrinogen also with dehydroepiandrosterone sulfate). Dehydroepiandrosterone Sulfate 144-174 fibrinogen beta chain Homo sapiens 123-133 15601711-5 2005 The most active of all these enzyme forms against several substrates, including human fibrinogen and beta-chain insulin, was the Ser-1-Glu227 (-1S-SprE) isolated from TX5264; -1S-SprE, in contrast to other forms of SprE, was unstable at 37 degrees C, apparently due to autodegradation. Serine 129-132 fibrinogen beta chain Homo sapiens 86-96 15662593-0 2005 Levels of plasma fibrinogen and d-dimer in patients with impaired fasting glucose. Glucose 74-81 fibrinogen beta chain Homo sapiens 17-27 15662593-3 2005 The present study was designed to evaluate plasma fibrinogen and D-dimer levels in patients with impaired fasting glucose compared with normal subjects and those with type 2 diabetes mellitus. Glucose 114-121 fibrinogen beta chain Homo sapiens 50-60 15662593-5 2005 RESULTS: The levels of plasma fibrinogen in patients with type 2 diabetes mellitus, impaired fasting glucose, and normal subjects were 449 (306 - 605) mg/dl, 348 (264 - 468) mg/dl, and 216 (179 - 260) mg/dl, respectively. Glucose 101-108 fibrinogen beta chain Homo sapiens 30-40 15662593-6 2005 Patients with impaired fasting glucose had significantly lower plasma fibrinogen levels than patients with type 2 diabetes mellitus (p < 0.05). Glucose 31-38 fibrinogen beta chain Homo sapiens 70-80 15662593-7 2005 There were significantly higher plasma fibrinogen levels in patients with impaired fasting glucose than in normal subjects (p < 0.05). Glucose 91-98 fibrinogen beta chain Homo sapiens 39-49 15662593-11 2005 The levels of plasma fibrinogen and D-dimer were related to fasting glucose in type 2 diabetes mellitus and impaired fasting glucose groups (p < 0.05). Glucose 68-75 fibrinogen beta chain Homo sapiens 21-31 15662593-11 2005 The levels of plasma fibrinogen and D-dimer were related to fasting glucose in type 2 diabetes mellitus and impaired fasting glucose groups (p < 0.05). Glucose 125-132 fibrinogen beta chain Homo sapiens 21-31 15694701-11 2005 These thiol groups can, in turn, initiate a disulfide exchange reaction with plasma proteins, predominantly with fibrinogen, to form an insoluble and protease-resistant fibrin-like polymer. Sulfhydryl Compounds 6-11 fibrinogen beta chain Homo sapiens 113-123 15614199-4 2005 MATERIAL/METHODS: In this study we investigated whether raloxifene is able to inhibit in vitro iron-mediated oxidation of fibrinogen. Raloxifene Hydrochloride 56-66 fibrinogen beta chain Homo sapiens 122-132 15614199-4 2005 MATERIAL/METHODS: In this study we investigated whether raloxifene is able to inhibit in vitro iron-mediated oxidation of fibrinogen. Iron 95-99 fibrinogen beta chain Homo sapiens 122-132 15614199-7 2005 Considering the chemical structure of the glycoprotein fibrinogen, it is likely that raloxifene is unable to attack a particle without lipophilic properties, although the site of its action on LDL is still unknown. Raloxifene Hydrochloride 85-95 fibrinogen beta chain Homo sapiens 55-65 15614199-8 2005 CONCLUSIONS: Our data suggest that raloxifene, in contrast to its effect on LDL, lacks the capability to inhibit the oxidation of fibrinogen. Raloxifene Hydrochloride 35-45 fibrinogen beta chain Homo sapiens 130-140 15694701-11 2005 These thiol groups can, in turn, initiate a disulfide exchange reaction with plasma proteins, predominantly with fibrinogen, to form an insoluble and protease-resistant fibrin-like polymer. Disulfides 44-53 fibrinogen beta chain Homo sapiens 113-123 15780504-7 2005 Moderate alcohol intake is associated with reduced serum PTH as well as decreased levels of CRP and fibrinogen; conceivably, modulation of PTH mediates, at least in part, the favorable impact of moderate drinking on the acute phase reactants. Alcohols 9-16 fibrinogen beta chain Homo sapiens 100-110 15849476-7 2005 Treatment with intraperitoneal tinzaparin was accompanied with a median 25.8% reduction of the plasma C-reactive protein concentration (p = 0.032), a 7.3% reduction of the plasma fibrinogen concentration (p = 0.042) and a 54.5% reduction of the dialysate interleukin 6 appearance rate (p = 0.007) compared with placebo. Tinzaparin 31-41 fibrinogen beta chain Homo sapiens 179-189 16149026-6 2005 Proteins of the blood sample, especially fibrinogen, and thereafter also activated platelets, bind to the specific polymer surface. Polymers 115-122 fibrinogen beta chain Homo sapiens 41-51 15907530-3 2005 In this study, we found that the clinical isolate S. aureus 30326 induced activation and aggregation of washed human platelets in a fibrinogen-dependent manner and this platelet reactivity was abrogated by crotavirin, a snake venom-derived glycoprotein (GP) IIb/IIIa antagonist, indicating that crotavirin is able to protect platelets from activation and aggregation by S. aureus 30326. crotavirin 206-216 fibrinogen beta chain Homo sapiens 132-142 15935833-12 2005 High [Ca(2+)] enhances spontaneous platelet fibrinogen binding, but reduces ADP-induced platelet fibrinogen binding, while low [Ca(2+)] enhances ADP-induced platelet fibrinogen binding. Adenosine Diphosphate 76-79 fibrinogen beta chain Homo sapiens 97-107 15935833-12 2005 High [Ca(2+)] enhances spontaneous platelet fibrinogen binding, but reduces ADP-induced platelet fibrinogen binding, while low [Ca(2+)] enhances ADP-induced platelet fibrinogen binding. Adenosine Diphosphate 76-79 fibrinogen beta chain Homo sapiens 97-107 15907530-4 2005 When tested at a concentration that prevented the platelet reactivity of S. aureus 30326, crotavirin also interfered with the binding of bacteria to washed human platelets supplemented with fibrinogen. crotavirin 90-100 fibrinogen beta chain Homo sapiens 190-200 15935833-5 2005 ADP-induced platelet fibrinogen binding was, however, higher at 0.125 mM, but lower at 5 and 10 mM [Ca(2+)], as compared to 1.25 mM [Ca(2+)]. Adenosine Diphosphate 0-3 fibrinogen beta chain Homo sapiens 21-31 15572240-0 2004 Review of some unusual effects of calcium binding to fibrinogen. Calcium 34-41 fibrinogen beta chain Homo sapiens 53-63 16181986-2 2005 The present study was performed to extend the dose-response curve for effects of ASA on fibrinogen clotting properties and to examine the variability of these effects during a 24-h dose interval. Aspirin 81-84 fibrinogen beta chain Homo sapiens 88-98 16181986-10 2005 CONCLUSIONS: Acetylation of lysine residues in the fibrinogen molecule may explain the alterations in its clotting property, resulting in altered fibrin gel permeability. Lysine 28-34 fibrinogen beta chain Homo sapiens 51-61 15572240-1 2004 Calcium binding curves of human and bovine fibrinogen were obtained by using a calcium sensitive electrode. Calcium 0-7 fibrinogen beta chain Homo sapiens 43-53 15572240-1 2004 Calcium binding curves of human and bovine fibrinogen were obtained by using a calcium sensitive electrode. Calcium 79-86 fibrinogen beta chain Homo sapiens 43-53 15572240-7 2004 In the absence of Ca2+ clotting elicited a 40% increase in the enthalpy of thermal denaturation of the D domain of fibrinogen, but the position of the peak increased only by 0.4 degrees C. However, with clotting in the presence of 10(-3) M calcium the former increased by 70-75% and the latter by 11.0 degrees C, while these parameters of the E-domain remained unchanged. Calcium 240-247 fibrinogen beta chain Homo sapiens 115-125 15572240-9 2004 These had to be corrected, because the drop in free calcium was partly compensated by release of some calcium that was already bound to fibrinogen. Calcium 102-109 fibrinogen beta chain Homo sapiens 136-146 15457437-4 2004 When FBG was prepared by the 2KBr method and pressure was increased up to 400 kg/cm(2), peaks at 1625 (intermolecular beta-sheet) and 1611 (beta-sheet aggregates structure and/or the side-chain absorption of the tyrosine residues) cm(-1) were enhanced. Tyrosine 212-220 fibrinogen beta chain Homo sapiens 5-8 15530472-6 2004 Nilvadipine also reduced the expression of fibrinogen and plasminogen activator inhibitor-1 (PAI-1). nilvadipine 0-11 fibrinogen beta chain Homo sapiens 43-53 15558516-1 2004 BACKGROUND: Concentrations of plasma fibrinogen, a vascular risk factor, tend to be greater in patients on peritoneal dialysis (PD) than hemodialysis (HD) therapy, like concentrations of serum cholesterol, lipoprotein(a), and transthyretin, despite the substantial loss of protein during PD. Cholesterol 193-204 fibrinogen beta chain Homo sapiens 37-47 15530472-7 2004 CONCLUSIONS: Since NF-kappaB-mediated gene products, such as fibrinogen and PAI-1, are known to facilitate hypercoagulation, thrombosis and vascular events, we suggest that nilvadipine has a direct beneficial effect separate from its anti-hypertensive properties by inhibiting NF-kappaB-dependent gene expression and eventually inhibiting atherosclerosis. nilvadipine 173-184 fibrinogen beta chain Homo sapiens 61-71 15578956-8 2004 For example, platelet aggregation inhibitors, which interfere in the interactions between fibrinogen and its receptor, the glycoprotein IIb/IIIa complex, show extreme structural diversity but they share the common functional site of Arg-Gly-Asp (RGD) tripeptide segment. Arginine 233-236 fibrinogen beta chain Homo sapiens 90-100 15578956-8 2004 For example, platelet aggregation inhibitors, which interfere in the interactions between fibrinogen and its receptor, the glycoprotein IIb/IIIa complex, show extreme structural diversity but they share the common functional site of Arg-Gly-Asp (RGD) tripeptide segment. glycylaspartic acid 237-244 fibrinogen beta chain Homo sapiens 90-100 15578956-8 2004 For example, platelet aggregation inhibitors, which interfere in the interactions between fibrinogen and its receptor, the glycoprotein IIb/IIIa complex, show extreme structural diversity but they share the common functional site of Arg-Gly-Asp (RGD) tripeptide segment. tripeptide K-26 251-261 fibrinogen beta chain Homo sapiens 90-100 15571824-6 2004 Self-reported moderate daily alcohol intake up to 40 g was associated with lower concentrations of CRP, fibrinogen, PV and WBC count, compared to non-drinking and heavy drinking, even after adjustment for various potential confounders. Alcohols 29-36 fibrinogen beta chain Homo sapiens 104-114 15613026-6 2004 This novel His-->Tyr substitution was not detected when plasma fibrinogen was analyzed by electrospray ionization mass spectrometry. Histidine 11-14 fibrinogen beta chain Homo sapiens 63-73 15606724-7 2004 RESULTS: Alcohol inhibited platelet adhesion to human fibrinogen at high shear rate (concentrations > or = 0.15 per thousand) and low shear rate (only at a concentration of 4.8 per thousand), whereas red wine (concentrations > or = 0.15 per thousand) inhibited platelet adhesion to human fibrinogen at both shear rates. Alcohols 9-16 fibrinogen beta chain Homo sapiens 54-64 15606724-7 2004 RESULTS: Alcohol inhibited platelet adhesion to human fibrinogen at high shear rate (concentrations > or = 0.15 per thousand) and low shear rate (only at a concentration of 4.8 per thousand), whereas red wine (concentrations > or = 0.15 per thousand) inhibited platelet adhesion to human fibrinogen at both shear rates. Alcohols 9-16 fibrinogen beta chain Homo sapiens 294-304 15606724-8 2004 In contrast, PGE (concentrations > or = 0.0225 g L(-1)) inhibited platelet adhesion to human fibrinogen only at low shear rate. phenylglycidyl ether 13-16 fibrinogen beta chain Homo sapiens 96-106 15606724-10 2004 CONCLUSIONS: Alcohol, red wine and PGE inhibit adhesion to fibrinogen but not to collagen. Alcohols 13-20 fibrinogen beta chain Homo sapiens 59-69 15606724-10 2004 CONCLUSIONS: Alcohol, red wine and PGE inhibit adhesion to fibrinogen but not to collagen. red wine 22-30 fibrinogen beta chain Homo sapiens 59-69 15606724-10 2004 CONCLUSIONS: Alcohol, red wine and PGE inhibit adhesion to fibrinogen but not to collagen. phenylglycidyl ether 35-38 fibrinogen beta chain Homo sapiens 59-69 15613026-6 2004 This novel His-->Tyr substitution was not detected when plasma fibrinogen was analyzed by electrospray ionization mass spectrometry. Tyrosine 17-20 fibrinogen beta chain Homo sapiens 63-73 15613026-10 2004 However, the histidine residue appears critical in maintaining structure of the fibrinogen gammaD domain, rather than in determining function. Histidine 13-22 fibrinogen beta chain Homo sapiens 80-90 15583736-0 2004 Hypofibrinogenaemia associated with a novel heterozygous gamma289 Ala -->Val substitution (fibrinogen Dorfen). gamma289 57-65 fibrinogen beta chain Homo sapiens 4-14 15583736-2 2004 DNA sequencing revealed a single heterozygous GCC-->GTC transition in exon 8 of the fibrinogen gamma ?gene in both subjects, predicting a novel gamma289 Ala-->Val substitution. gamma289 144-152 fibrinogen beta chain Homo sapiens 84-94 15583736-2 2004 DNA sequencing revealed a single heterozygous GCC-->GTC transition in exon 8 of the fibrinogen gamma ?gene in both subjects, predicting a novel gamma289 Ala-->Val substitution. Alanine 153-156 fibrinogen beta chain Homo sapiens 84-94 15583736-2 2004 DNA sequencing revealed a single heterozygous GCC-->GTC transition in exon 8 of the fibrinogen gamma ?gene in both subjects, predicting a novel gamma289 Ala-->Val substitution. Valine 159-162 fibrinogen beta chain Homo sapiens 84-94 15583736-6 2004 Our finding that gamma289 is an important determinant of plasma fibrinogen levels highlights the role of mutational analysis in defining structurally important regions of the fibrinogen molecule. gamma289 17-25 fibrinogen beta chain Homo sapiens 64-74 15583736-6 2004 Our finding that gamma289 is an important determinant of plasma fibrinogen levels highlights the role of mutational analysis in defining structurally important regions of the fibrinogen molecule. gamma289 17-25 fibrinogen beta chain Homo sapiens 175-185 15583747-6 2004 A distinct feature of these cells is the failure of DTT to enhance the binding to soluble Fg and the formation of cell aggregates. Dithiothreitol 52-55 fibrinogen beta chain Homo sapiens 90-92 15598024-2 2004 The aim of this study was to assess the effect of 30-day atorvastatin treatment on major hemostatic risk factors (fibrinogen, PAI-1 levels, factor VII coagulant activity) in patients with primary hypercholesterolemia. Atorvastatin 57-69 fibrinogen beta chain Homo sapiens 114-124 15598024-5 2004 Atorvastatin (20 mg/d) not only decreased total cholesterol, LDL cholesterol and oxidized LDL, but also reduced PAI-1 levels and factor VII activity and tended to decrease fibrinogen levels. Atorvastatin 0-12 fibrinogen beta chain Homo sapiens 172-182 15662091-0 2004 Effect of simvastatin and fluvastatin on plasma fibrinogen levels in patients with primary hypercholesterolemia. Simvastatin 10-21 fibrinogen beta chain Homo sapiens 48-58 15662091-0 2004 Effect of simvastatin and fluvastatin on plasma fibrinogen levels in patients with primary hypercholesterolemia. Fluvastatin 26-37 fibrinogen beta chain Homo sapiens 48-58 15662091-6 2004 After 4 weeks of treatment both drugs tended to increase plasma fibrinogen levels, while after 12 weeks fibrinogen level was significantly increased in the simvastatin-treated patients. Simvastatin 156-167 fibrinogen beta chain Homo sapiens 104-114 15543338-4 2004 Tyr178 --> Ala substitution (Tyr178Ala) and Asp218Ala abolished a monovalent ligand, WOW-1 Fab binding as well as soluble fibrinogen binding, which is in perfect agreement with the crystallography. Alanine 14-17 fibrinogen beta chain Homo sapiens 125-135 15673060-11 2004 Perindopril reduced fibrinogen levels in ACE II homozygotes due to its more potent inhibitory action on the renin-angiotensin system in such patients. Perindopril 0-11 fibrinogen beta chain Homo sapiens 20-30 15500456-0 2004 Cryoprecipitate prepared from plasma treated with methylene blue plus light: increasing the fibrinogen concentration. Methylene Blue 50-64 fibrinogen beta chain Homo sapiens 92-102 15500456-1 2004 When cryoprecipitate is prepared from plasma which has been treated with methylene blue plus light (MB) for the purpose of virus inactivation, clottable fibrinogen content is 40% lower compared with units prepared from untreated plasma. Methylene Blue 73-87 fibrinogen beta chain Homo sapiens 153-163 15379516-1 2004 Tapping-mode atomic force microscopy was used to study the time-dependent changes in the structure of fibrinogen under aqueous conditions following adsorption on two model surfaces: hydrophobic graphite and hydrophilic mica. Graphite 194-202 fibrinogen beta chain Homo sapiens 102-112 15379516-1 2004 Tapping-mode atomic force microscopy was used to study the time-dependent changes in the structure of fibrinogen under aqueous conditions following adsorption on two model surfaces: hydrophobic graphite and hydrophilic mica. mica 219-223 fibrinogen beta chain Homo sapiens 102-112 15379516-6 2004 Spreading kinetics of fibrinogen on the two surfaces was determined by measuring the heights of the D and E domains over a time period of approximately 2 h. On graphite, the heights of both the D and E domains decreased with time to a lower plateau value of 1.0 nm. Graphite 160-168 fibrinogen beta chain Homo sapiens 22-32 15379516-9 2004 A spreading rate constant of approximately 4.7 x 10(-4) s(-1) was observed for the whole fibrinogen molecule adsorbed on graphite, corresponding to a free energy of unfolding of approximately 37 kT. Graphite 121-129 fibrinogen beta chain Homo sapiens 89-99 15217806-9 2004 CONCLUSIONS: Dietary omega-3 PUFAs provoke a hypocoagulant, vitamin K-independent effect in humans, the degree of which may depend on fibrinogen level. Vitamin K 60-69 fibrinogen beta chain Homo sapiens 134-144 15481860-0 2004 Sodium reduces calcium binding to albumin and fibrinogen. Sodium 0-6 fibrinogen beta chain Homo sapiens 46-56 15324932-0 2004 Influence of arginine deimination on antigenicity of fibrinogen. Arginine 13-21 fibrinogen beta chain Homo sapiens 53-63 15229106-5 2004 Fibrinogen enhanced fMLP-induced tyrosine phosphorylation in human neutrophils and markedly enhanced the phosphorylation of mitogen-activated protein kinases (MAPK) caused by fMLP. Tyrosine 33-41 fibrinogen beta chain Homo sapiens 0-10 15229106-7 2004 Wortmannin, a phosphatidylinositol 3-kinase (PI3K) kinase inhibitor, and genistein, a nonspecific tyrosine kinase inhibitor, strongly inhibited fMLP-induced elastase release both in the presence and in the absence of fibrinogen. Wortmannin 0-10 fibrinogen beta chain Homo sapiens 217-227 15229106-7 2004 Wortmannin, a phosphatidylinositol 3-kinase (PI3K) kinase inhibitor, and genistein, a nonspecific tyrosine kinase inhibitor, strongly inhibited fMLP-induced elastase release both in the presence and in the absence of fibrinogen. Genistein 73-82 fibrinogen beta chain Homo sapiens 217-227 15229106-9 2004 Go6976, an inhibitor of classical PKC isoforms, caused a significant inhibition of fMLP-induced elastase release in the presence or absence of fibrinogen, while nonselective inhibitors of PKC, Ro 31-8220, GF-109203X, and staurosporine, caused potentiation of fMLP-induced elastase release. Go 6976 0-6 fibrinogen beta chain Homo sapiens 143-153 15573185-12 2004 Significant positive correlation was seen between fibrinogen and BMI, systolic and diastolic BP and total cholesterol. Cholesterol 106-117 fibrinogen beta chain Homo sapiens 50-60 15543331-0 2004 Fibrinogen adsorption and platelet adhesion to metal and carbon coatings. Carbon 57-63 fibrinogen beta chain Homo sapiens 0-10 15543331-3 2004 It has been shown that the adsorption of fibrinogen to metal and carbon coatings and its post-adsorptive transition are dependent on both the material properties and the fibrinogen environment. Metals 55-60 fibrinogen beta chain Homo sapiens 41-51 15543331-3 2004 It has been shown that the adsorption of fibrinogen to metal and carbon coatings and its post-adsorptive transition are dependent on both the material properties and the fibrinogen environment. Metals 55-60 fibrinogen beta chain Homo sapiens 170-180 15543331-3 2004 It has been shown that the adsorption of fibrinogen to metal and carbon coatings and its post-adsorptive transition are dependent on both the material properties and the fibrinogen environment. Carbon 65-71 fibrinogen beta chain Homo sapiens 41-51 15543331-3 2004 It has been shown that the adsorption of fibrinogen to metal and carbon coatings and its post-adsorptive transition are dependent on both the material properties and the fibrinogen environment. Carbon 65-71 fibrinogen beta chain Homo sapiens 170-180 15543331-4 2004 The adsorption of fibrinogen from human plasma on titanium and zirconium coatings is similar to that on uncoated stainless steel surface. Titanium 50-58 fibrinogen beta chain Homo sapiens 18-28 15543331-4 2004 The adsorption of fibrinogen from human plasma on titanium and zirconium coatings is similar to that on uncoated stainless steel surface. Zirconium 63-72 fibrinogen beta chain Homo sapiens 18-28 15543331-5 2004 Both carbon coatings adsorb much greater amount of fibrinogen from plasma, and fibrinogen retention by carbon surfaces is also greater than by metal surfaces. Carbon 5-11 fibrinogen beta chain Homo sapiens 51-61 15543331-5 2004 Both carbon coatings adsorb much greater amount of fibrinogen from plasma, and fibrinogen retention by carbon surfaces is also greater than by metal surfaces. Carbon 103-109 fibrinogen beta chain Homo sapiens 79-89 15493920-1 2004 The adsorption of fibrinogen (Fb) and bovine serum albumin onto polycrystalline Au coated with HS(CH2)3O(CH2CH2O)5CH3 was determined by surface plasmon resonance from bare Au (0% coverage) to the complete ( approximately 100% coverage) self-assembled monolayer (SAM). polycrystalline au 64-82 fibrinogen beta chain Homo sapiens 18-28 15493920-1 2004 The adsorption of fibrinogen (Fb) and bovine serum albumin onto polycrystalline Au coated with HS(CH2)3O(CH2CH2O)5CH3 was determined by surface plasmon resonance from bare Au (0% coverage) to the complete ( approximately 100% coverage) self-assembled monolayer (SAM). polycrystalline au 64-82 fibrinogen beta chain Homo sapiens 30-32 15493920-1 2004 The adsorption of fibrinogen (Fb) and bovine serum albumin onto polycrystalline Au coated with HS(CH2)3O(CH2CH2O)5CH3 was determined by surface plasmon resonance from bare Au (0% coverage) to the complete ( approximately 100% coverage) self-assembled monolayer (SAM). hs(ch2)3o(ch2ch2o)5ch3 95-117 fibrinogen beta chain Homo sapiens 18-28 15493920-1 2004 The adsorption of fibrinogen (Fb) and bovine serum albumin onto polycrystalline Au coated with HS(CH2)3O(CH2CH2O)5CH3 was determined by surface plasmon resonance from bare Au (0% coverage) to the complete ( approximately 100% coverage) self-assembled monolayer (SAM). Gold 80-82 fibrinogen beta chain Homo sapiens 18-28 15493920-1 2004 The adsorption of fibrinogen (Fb) and bovine serum albumin onto polycrystalline Au coated with HS(CH2)3O(CH2CH2O)5CH3 was determined by surface plasmon resonance from bare Au (0% coverage) to the complete ( approximately 100% coverage) self-assembled monolayer (SAM). Gold 80-82 fibrinogen beta chain Homo sapiens 30-32 15389122-0 2004 A novel mutation (deletion of Aalpha-Asn 80) in an abnormal fibrinogen: fibrinogen Caracas VI. Asparagine 37-40 fibrinogen beta chain Homo sapiens 60-70 15389122-0 2004 A novel mutation (deletion of Aalpha-Asn 80) in an abnormal fibrinogen: fibrinogen Caracas VI. Asparagine 37-40 fibrinogen beta chain Homo sapiens 72-82 15389122-9 2004 DNA sequencing of the propositus and his mother revealed a new unique point mutation that gives rise to a fibrinogen molecule with a missing amino acid residue at Aalpha-Asn 80. fenvalerate 163-170 fibrinogen beta chain Homo sapiens 106-116 15389122-9 2004 DNA sequencing of the propositus and his mother revealed a new unique point mutation that gives rise to a fibrinogen molecule with a missing amino acid residue at Aalpha-Asn 80. Asparagine 170-173 fibrinogen beta chain Homo sapiens 106-116 15369747-6 2004 In diabetic patients, plasma tHcy correlated positively with urinary albumin, fibrinogen, IL-6 and plasmin-alpha2-antiplasmin complex (PAP), while plasma tHcy correlated negatively with creatinine clearance (Ccr) and protein C activity. thcy 29-33 fibrinogen beta chain Homo sapiens 78-88 15502925-5 2004 RESULTS: In age-adjusted analyses, alcohol intake was associated with lower levels of HbA1c, fibrinogen, soluble tumour necrosis factor receptor-2 (sTNF-R2) and soluble vascular adhesion molecule-1 (sVCAM-1), and with higher levels of HDL cholesterol and adiponectin (p value for trends <0.05). Alcohols 35-42 fibrinogen beta chain Homo sapiens 93-103 15467918-5 2004 Preincubation with Mn(2+) lowered the fibrinogen concentration-dependence, consistent with integrin activation. Manganese(2+) 19-25 fibrinogen beta chain Homo sapiens 38-48 15467918-9 2004 Parthenolide, an IkappaB kinase inhibitor, prevented up-regulation of MCP-1 by fibrinogen, linking this response to NF-kappaB activation. parthenolide 0-12 fibrinogen beta chain Homo sapiens 79-89 15665914-5 2004 ADP initiated platelet aggregation, which was in direct proportion to the degree of fibrinogen oxidation. Adenosine Diphosphate 0-3 fibrinogen beta chain Homo sapiens 84-94 15583736-0 2004 Hypofibrinogenaemia associated with a novel heterozygous gamma289 Ala -->Val substitution (fibrinogen Dorfen). Alanine 66-69 fibrinogen beta chain Homo sapiens 4-14 15583736-0 2004 Hypofibrinogenaemia associated with a novel heterozygous gamma289 Ala -->Val substitution (fibrinogen Dorfen). Valine 73-76 fibrinogen beta chain Homo sapiens 4-14 15333041-9 2004 Addition of LM609, a monoclonal antibody to alphaVbeta3, significantly inhibited induction of u-PA mRNA and activity by fibrinogen-bound FGF-2 compared to FGF-2. lm609 12-17 fibrinogen beta chain Homo sapiens 120-130 15326822-0 2004 Atorvastatin reduces fibrinogen levels in patients with severe hypercholesterolemia: additional evidence to support the anti-inflammatory effects of statins. Atorvastatin 0-12 fibrinogen beta chain Homo sapiens 21-31 15309577-6 2004 Furthermore cholesterol was inversely related to phenylalanine, fibrinogen, lactate and white blood cell count, and directly to the Fischer molar amino acid ratio, cystathionine, methionine, glycine and transferrin (r2 between 0.36 and 0.15, p<0.0001 for all). Cholesterol 12-23 fibrinogen beta chain Homo sapiens 64-74 15326822-3 2004 OBJECTIVES: To evaluate the effect of atorvastatin on plasma fibrinogen levels in patients with severe hypercholesterolemia and no other risk factors. Atorvastatin 38-50 fibrinogen beta chain Homo sapiens 61-71 15326822-12 2004 CONCLUSIONS: We found that atorvastatin reduces plasma fibrinogen in patients with hypercholesterolemia. Atorvastatin 27-39 fibrinogen beta chain Homo sapiens 55-65 15304042-8 2004 Moreover, the existence of a subsequent disulfide-linked Cys in gamma 275C fibrinogen augments the impairment caused by a His or Ala substitution. Disulfides 40-49 fibrinogen beta chain Homo sapiens 75-85 15304042-8 2004 Moreover, the existence of a subsequent disulfide-linked Cys in gamma 275C fibrinogen augments the impairment caused by a His or Ala substitution. Cysteine 57-60 fibrinogen beta chain Homo sapiens 75-85 15304042-8 2004 Moreover, the existence of a subsequent disulfide-linked Cys in gamma 275C fibrinogen augments the impairment caused by a His or Ala substitution. Histidine 122-125 fibrinogen beta chain Homo sapiens 75-85 15304042-8 2004 Moreover, the existence of a subsequent disulfide-linked Cys in gamma 275C fibrinogen augments the impairment caused by a His or Ala substitution. Alanine 129-132 fibrinogen beta chain Homo sapiens 75-85 15281005-9 2004 Total body fat (P < .0001) and LDL-cholesterol (P < .01) were the independent predictors of fibrinogen levels, accounting for 29.5% and 10.9% of its variance, respectively. Cholesterol 38-49 fibrinogen beta chain Homo sapiens 98-108 15274763-0 2004 [Relationship between cholesterol and fibrinogen in two populations of different geographical location of Catalonia]. Cholesterol 22-33 fibrinogen beta chain Homo sapiens 38-48 15233977-10 2004 CONCLUSIONS: In hypertensive smokers, nebivolol resulted in a significant decrease of plasma PAI-1, fibrinogen and homocystine. Nebivolol 38-47 fibrinogen beta chain Homo sapiens 100-110 15039285-6 2004 Binding of (125)I-IL-1beta to Sepharose-immobilized fibrinogen also demonstrated a single binding site with an apparent K(d) of 3.5 nM. Sepharose 30-39 fibrinogen beta chain Homo sapiens 52-62 15039285-9 2004 Compared with free form, fibrinogen-bound IL-1beta stimulated increased activation of endothelial cell nuclear factor kappaB (NF-kappaB), monocyte chemoattractant protein-1 (MCP-1) secretion, and nitric oxide (NO) synthesis. Nitric Oxide 196-208 fibrinogen beta chain Homo sapiens 25-35 15136070-5 2004 Fenofibrate reduced fibrinogen and plasminogen activator inhibitor type 1 antigen levels by 17 +/- 3 and 10 +/- 3%, respectively (P < 0.001 and P = 0.014, respectively). Fenofibrate 0-11 fibrinogen beta chain Homo sapiens 20-30 15258682-14 2004 Policosanol induced modest, but significant, reductions (p < 0.01) of fibrinogen levels compared with baseline and ticlopidine. policosanol 0-11 fibrinogen beta chain Homo sapiens 73-83 15027894-2 2004 In the present study, we tested for an association of overnight urinary catecholamine and cortisol excretion with morning plasma levels of fibrinogen, PAI-1 (plasminogen activator inhibitor-1) and D-dimer. Catecholamines 72-85 fibrinogen beta chain Homo sapiens 139-149 15027894-7 2004 Fibrinogen was higher in men with high adrenaline (F(7,631)=5.68, P=0.018; where the subscripted value represents the degrees of freedom) and high noradrenaline (F(7,631)=4.19, P=0.041) compared with men with low excretion of the respective hormones. Epinephrine 39-49 fibrinogen beta chain Homo sapiens 0-10 15027894-7 2004 Fibrinogen was higher in men with high adrenaline (F(7,631)=5.68, P=0.018; where the subscripted value represents the degrees of freedom) and high noradrenaline (F(7,631)=4.19, P=0.041) compared with men with low excretion of the respective hormones. Norepinephrine 147-160 fibrinogen beta chain Homo sapiens 0-10 15505985-6 2004 Gestational hyperglycemia and fasting glucose values were also associated to subsequent fibrinogen values, but not to albumin excretion rates. Glucose 38-45 fibrinogen beta chain Homo sapiens 88-98 15166913-0 2004 Biophysical characterization of fibrinogen Caracas I with an Aalpha-chain truncation at Aalpha-466 Ser: identification of the mutation and biophysical characterization of properties of clots from plasma and purified fibrinogen. Serine 99-102 fibrinogen beta chain Homo sapiens 32-42 15166913-1 2004 Fibrinogen Caracas I is a dysfibrinogenemia with a mild bleeding tendency; a novel nonsense mutation, in the gene coding the Aalpha-chain, identified in this study as G4731T, giving rise to a new stop codon at Aalpha-Glu 467. Glutamic Acid 217-220 fibrinogen beta chain Homo sapiens 0-10 15193272-3 2004 Fibrinogen was purified from barium sulphate adsorbed plasma of Atlantic salmon, using two steps of 25% ammonium sulphate precipitation followed by ultrafiltration. Barium Sulfate 29-44 fibrinogen beta chain Homo sapiens 0-10 15193272-3 2004 Fibrinogen was purified from barium sulphate adsorbed plasma of Atlantic salmon, using two steps of 25% ammonium sulphate precipitation followed by ultrafiltration. Ammonium Sulfate 104-121 fibrinogen beta chain Homo sapiens 0-10 15284011-1 2004 Triflamp, a 28 kDa snake venom metalloproteinase purified from the venom of Trimeresurus flavoviridis, possesses the proteolytic activities toward P-selectin glycoprotein ligand-1 (PSGL-1), glycoprotein Ib (GPIb) and fibrinogen. triflamp 0-8 fibrinogen beta chain Homo sapiens 217-227 15284011-3 2004 Human alpha2-macroglobulin (alpha2M) was mainly responsible for the neutralization of the proteolytic effects of triflamp on PSGL-1, GPIb and fibrinogen. triflamp 113-121 fibrinogen beta chain Homo sapiens 142-152 15007078-4 2004 These differences could be ascribed to an enhanced interaction of the Ser-700 variant with fibrinogen on the platelet surface and are consistent with a prothrombotic phenotype in Ser-700 individuals. Serine 70-73 fibrinogen beta chain Homo sapiens 91-101 15007078-4 2004 These differences could be ascribed to an enhanced interaction of the Ser-700 variant with fibrinogen on the platelet surface and are consistent with a prothrombotic phenotype in Ser-700 individuals. Serine 179-182 fibrinogen beta chain Homo sapiens 91-101 15134514-4 2004 The search for these compounds is based on the molecular design of structures mimicking some fragment of RGD (Arg-Gly-Asp) sequence, responsible for the binding of fibrinogen to GP IIb/IIIa. Arginine 110-113 fibrinogen beta chain Homo sapiens 164-174 15134514-4 2004 The search for these compounds is based on the molecular design of structures mimicking some fragment of RGD (Arg-Gly-Asp) sequence, responsible for the binding of fibrinogen to GP IIb/IIIa. glycylaspartic acid 114-121 fibrinogen beta chain Homo sapiens 164-174 15134514-6 2004 The modification of natural peptide structures for obtaining of more active and selective fibrinogen receptor antagonists is realized in several ways: substitution of main pharmacophores of RGD sequence; cyclization of RGD-containing peptides; design of conformationally constrained peptidomimetics. Peptides 234-242 fibrinogen beta chain Homo sapiens 90-100 15103514-4 2004 Mean fibrinogen levels among smokers and non-smokers in the four subpopulations of this hypercholesterolemic cohort followed mean total cholesterol levels. Cholesterol 93-104 fibrinogen beta chain Homo sapiens 5-15 15168063-7 2004 After adjusting the CRP levels, fibrinogen was positively associated with age, smoking status, total cholesterol, and hemoglobin A(1c) (HbA(1c)) in men, and with age, total cholesterol, and HbA(1c) in women. Cholesterol 101-112 fibrinogen beta chain Homo sapiens 32-42 15168063-7 2004 After adjusting the CRP levels, fibrinogen was positively associated with age, smoking status, total cholesterol, and hemoglobin A(1c) (HbA(1c)) in men, and with age, total cholesterol, and HbA(1c) in women. Cholesterol 173-184 fibrinogen beta chain Homo sapiens 32-42 15168063-8 2004 On the other hand, high-density lipoprotein (HDL) cholesterol was a strong negative correlate of fibrinogen in both genders. Cholesterol 50-61 fibrinogen beta chain Homo sapiens 97-107 15154777-21 2004 Thus, the Surrogate Model can be used to accurately and unambiguously identify polymers whose fibrinogen absorption is at the limits of the range (i.e., low or high) which is an essential requirement for assessing polymers for regenerative tissue applications. Polymers 79-87 fibrinogen beta chain Homo sapiens 94-104 15068907-0 2004 The effect of short course high dose methylprednisolon therapy on fibrinogen level in children with acute lymphoblastic leukemia. Methylprednisolone 37-54 fibrinogen beta chain Homo sapiens 66-76 15068907-3 2004 Fibrinogen levels decreased in both groups at day 5 which was statistically significant in the HDMP group. hdmp 95-99 fibrinogen beta chain Homo sapiens 0-10 14764586-7 2004 A similar global effect of fenofibrate on acute phase protein expression is observed in hyperlipidemic patients chronically treated with fenofibrate, which displayed decreased plasma concentrations of the positive APR proteins fibrinogen, C-reactive protein, serum amyloid A, plasminogen, and alpha2-macroglobulin and increased plasma concentrations of the negative APR albumin, underlining the clinical significance of our findings. Fenofibrate 27-38 fibrinogen beta chain Homo sapiens 227-237 14764586-7 2004 A similar global effect of fenofibrate on acute phase protein expression is observed in hyperlipidemic patients chronically treated with fenofibrate, which displayed decreased plasma concentrations of the positive APR proteins fibrinogen, C-reactive protein, serum amyloid A, plasminogen, and alpha2-macroglobulin and increased plasma concentrations of the negative APR albumin, underlining the clinical significance of our findings. Fenofibrate 137-148 fibrinogen beta chain Homo sapiens 227-237 15177126-4 2004 Among participants without confirmed cardiovascular disease, alcohol consumption was inversely associated with WBC, factor VIIIc, and fibrinogen level, and positively associated with albumin concentration in multivariate analyses. Alcohols 61-68 fibrinogen beta chain Homo sapiens 134-144 15042126-10 2004 Patients who were in the highest quartile of plasma arginine concentrations had significantly lower fibrinogen concentrations, higher lactic acid concentrations, and longer prothrombin time. Arginine 52-60 fibrinogen beta chain Homo sapiens 100-110 15042128-8 2004 Fibrinogen decreased with higher alcohol groups up to 10-20 g/day for women and 20-30 g/day for men. Alcohols 33-40 fibrinogen beta chain Homo sapiens 0-10 14681238-0 2004 Pro-thrombotic state induced by post-translational modification of fibrinogen by reactive nitrogen species. Reactive Nitrogen Species 81-106 fibrinogen beta chain Homo sapiens 67-77 14681238-4 2004 Exposure of fibrinogen to nitrating oxidants, including those produced by the myeloperoxidase-hydrogen peroxide-nitrite system, significantly accelerates clot formation and factor XIII cross-linking, whereas exposure of fibrinogen to non-nitrating oxidants decelerates clot formation. Hydrogen Peroxide 94-111 fibrinogen beta chain Homo sapiens 12-22 14681238-4 2004 Exposure of fibrinogen to nitrating oxidants, including those produced by the myeloperoxidase-hydrogen peroxide-nitrite system, significantly accelerates clot formation and factor XIII cross-linking, whereas exposure of fibrinogen to non-nitrating oxidants decelerates clot formation. Hydrogen Peroxide 94-111 fibrinogen beta chain Homo sapiens 220-230 14681238-4 2004 Exposure of fibrinogen to nitrating oxidants, including those produced by the myeloperoxidase-hydrogen peroxide-nitrite system, significantly accelerates clot formation and factor XIII cross-linking, whereas exposure of fibrinogen to non-nitrating oxidants decelerates clot formation. Nitrites 112-119 fibrinogen beta chain Homo sapiens 12-22 14681238-4 2004 Exposure of fibrinogen to nitrating oxidants, including those produced by the myeloperoxidase-hydrogen peroxide-nitrite system, significantly accelerates clot formation and factor XIII cross-linking, whereas exposure of fibrinogen to non-nitrating oxidants decelerates clot formation. Nitrites 112-119 fibrinogen beta chain Homo sapiens 220-230 15232628-0 2004 Mechanism of activation of ADP-induced platelet aggregation under the influence of oxidatively modified fibrinogen. Adenosine Diphosphate 27-30 fibrinogen beta chain Homo sapiens 104-114 15232628-4 2004 Phospholipase C inhibitor U73122 markedly suppressed platelet aggregation in the presence of oxidized and nonoxidized fibrinogen. 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione 26-32 fibrinogen beta chain Homo sapiens 118-128 15104216-5 2004 RESULTS: Plasma fibrinogen was higher in AA homozygous participants (341 mg/dL) than in participants carrying the G allele: GA (290 mg/dL), GG (298 mg/dL) in the control group. Gallium 124-126 fibrinogen beta chain Homo sapiens 16-26 15104216-6 2004 Plasma fibrinogen was also higher in AA homozygous patients (353 mg/dL) than in cases carrying the G allele: GA (287 mg/dL), GG (302 mg/dL) in the ICVD group. Gallium 109-111 fibrinogen beta chain Homo sapiens 7-17 15259286-0 2004 Low-dose oral combination of 17beta-estradiol and norethisterone acetate in postmenopausal women decreases factor VII, fibrinogen, antithrombin and plasminogen activator inhibitor-1. Estradiol 29-45 fibrinogen beta chain Homo sapiens 119-129 15259286-0 2004 Low-dose oral combination of 17beta-estradiol and norethisterone acetate in postmenopausal women decreases factor VII, fibrinogen, antithrombin and plasminogen activator inhibitor-1. Norethindrone Acetate 50-72 fibrinogen beta chain Homo sapiens 119-129 15259286-5 2004 RESULTS: The two low doses of E2-NETA induced significantly lower plasma levels of factor VII, fibrinogen, antithrombin and plasminogen activator inhibitor-1 (PAI-1), compared with placebo treatmen CONCLUSIONS: Low-dose E2 (1 mg) in combination with NETA resulted in favorable changes of factor VII activity and fibrinogen, compared with placebo. e2-neta 30-37 fibrinogen beta chain Homo sapiens 95-105 15259286-5 2004 RESULTS: The two low doses of E2-NETA induced significantly lower plasma levels of factor VII, fibrinogen, antithrombin and plasminogen activator inhibitor-1 (PAI-1), compared with placebo treatmen CONCLUSIONS: Low-dose E2 (1 mg) in combination with NETA resulted in favorable changes of factor VII activity and fibrinogen, compared with placebo. e2-neta 30-37 fibrinogen beta chain Homo sapiens 312-322 15259286-5 2004 RESULTS: The two low doses of E2-NETA induced significantly lower plasma levels of factor VII, fibrinogen, antithrombin and plasminogen activator inhibitor-1 (PAI-1), compared with placebo treatmen CONCLUSIONS: Low-dose E2 (1 mg) in combination with NETA resulted in favorable changes of factor VII activity and fibrinogen, compared with placebo. Norethindrone Acetate 33-37 fibrinogen beta chain Homo sapiens 95-105 15259286-5 2004 RESULTS: The two low doses of E2-NETA induced significantly lower plasma levels of factor VII, fibrinogen, antithrombin and plasminogen activator inhibitor-1 (PAI-1), compared with placebo treatmen CONCLUSIONS: Low-dose E2 (1 mg) in combination with NETA resulted in favorable changes of factor VII activity and fibrinogen, compared with placebo. Norethindrone Acetate 33-37 fibrinogen beta chain Homo sapiens 312-322 14762929-0 2004 Small changes in the polymer structure influence the adsorption behavior of fibrinogen on polymer surfaces: validation of a new rapid screening technique. Polymers 21-28 fibrinogen beta chain Homo sapiens 76-86 14762929-5 2004 The screening assay was used to measure the adsorption of human fibrinogen on 46 test polymers (44 polyarylates selected from a combinatorial library of tyrosine-derived polyarylates, and two lactide-based polymers). Tyrosine 153-161 fibrinogen beta chain Homo sapiens 64-74 14762929-5 2004 The screening assay was used to measure the adsorption of human fibrinogen on 46 test polymers (44 polyarylates selected from a combinatorial library of tyrosine-derived polyarylates, and two lactide-based polymers). lactide-based polymers 192-214 fibrinogen beta chain Homo sapiens 64-74 14762929-8 2004 Thus, when the test polymers were grouped by backbone composition, increased hydrophobicity of the pendent chain was significantly correlated with reduced fibrinogen adsorption. Polymers 20-28 fibrinogen beta chain Homo sapiens 155-165 14762929-11 2004 Further, we demonstrate that small changes in chemical composition can significantly influence the adsorption of human fibrinogen on polymer surfaces. Polymers 133-140 fibrinogen beta chain Homo sapiens 119-129 14762929-12 2004 The lactide-based polymers were among those polymers exhibiting the highest tendency to adsorb fibrinogen. lactide-based polymers 4-26 fibrinogen beta chain Homo sapiens 95-105 14762929-12 2004 The lactide-based polymers were among those polymers exhibiting the highest tendency to adsorb fibrinogen. Polymers 18-26 fibrinogen beta chain Homo sapiens 95-105 14613890-5 2004 ATP and UTP were equally potent in causing elastase release from human neutrophils in the presence of exogenous soluble fibrinogen, whereas ADP and UDP were without effect. Adenosine Triphosphate 0-3 fibrinogen beta chain Homo sapiens 120-130 15009465-0 2004 Recombinant fibrinogen, gamma275Arg-->Cys, exhibits formation of disulfide bond with cysteine and severely impaired D:D interactions. Cysteine 41-44 fibrinogen beta chain Homo sapiens 12-22 15009465-0 2004 Recombinant fibrinogen, gamma275Arg-->Cys, exhibits formation of disulfide bond with cysteine and severely impaired D:D interactions. Disulfides 68-77 fibrinogen beta chain Homo sapiens 12-22 15009465-0 2004 Recombinant fibrinogen, gamma275Arg-->Cys, exhibits formation of disulfide bond with cysteine and severely impaired D:D interactions. Cysteine 88-96 fibrinogen beta chain Homo sapiens 12-22 15009465-2 2004 We have already reported impaired fibrin polymerization in a variant fibrinogen (gammaArg275Cys), the Cys being located in the D:D interface. Cysteine 92-95 fibrinogen beta chain Homo sapiens 69-79 15072729-6 2004 RESULTS: Among nondiabetic women, current PHT users had lower mean fibrinogen, PAI1, and low-density lipoprotein cholesterol (LDLC) levels than those in never users (38.4 mg/dl, 8.68 ng/ml, and 14.16 mg/dl lower, respectively) but higher CRP and triglyceride levels (1.53 mg/l and 31.43 mg/dl higher, respectively). pht 42-45 fibrinogen beta chain Homo sapiens 67-77 14751260-0 2004 Monitoring the formation of Maillard reaction products of glucosamine with fibrinogen and human serum albumin using capillary electrophoresis. Glucosamine 58-69 fibrinogen beta chain Homo sapiens 75-85 14751260-1 2004 Formation of Maillard reaction products (MRP) of glucosamine (GlcN) with fibrinogen and human serum albumin (HSA), under simulated physiological conditions, was detected by fluorescence (excitation/emission: 340/420 nm) and UV/Vis (max. Glucosamine 49-60 fibrinogen beta chain Homo sapiens 73-83 14751260-1 2004 Formation of Maillard reaction products (MRP) of glucosamine (GlcN) with fibrinogen and human serum albumin (HSA), under simulated physiological conditions, was detected by fluorescence (excitation/emission: 340/420 nm) and UV/Vis (max. Glucosamine 62-66 fibrinogen beta chain Homo sapiens 73-83 14751260-3 2004 The application of polyacrylamide gel electrophoresis demonstrated the generation of high-molecular-weight fibrinogen and HSA MRP by GlcN. polyacrylamide 19-33 fibrinogen beta chain Homo sapiens 107-117 14751260-3 2004 The application of polyacrylamide gel electrophoresis demonstrated the generation of high-molecular-weight fibrinogen and HSA MRP by GlcN. Glucosamine 133-137 fibrinogen beta chain Homo sapiens 107-117 14613890-5 2004 ATP and UTP were equally potent in causing elastase release from human neutrophils in the presence of exogenous soluble fibrinogen, whereas ADP and UDP were without effect. Uridine Triphosphate 8-11 fibrinogen beta chain Homo sapiens 120-130 14752343-15 2004 This may be due to elevated fibrinogen levels induced by Amicar. Aminocaproic Acid 57-63 fibrinogen beta chain Homo sapiens 28-38 15049721-4 2004 Increased platelet thromboxane production as well as activation of platelet receptors for fibrinogen and or adenosine diphosphate (ADP) are often present, and can be treated with aspirin (acetylsalicylic acid) and/or receptor blockers. Aspirin 179-186 fibrinogen beta chain Homo sapiens 90-100 14736431-6 2004 With the same agonists, fibrinogen binding was significantly reduced after clopidogrel by 70%, 64%, and 81% (all p < 0.0001) and again further reduced with eptifibatide by 90%, 95%, and 69% (all p < 0.0001). Clopidogrel 75-86 fibrinogen beta chain Homo sapiens 24-34 14736431-6 2004 With the same agonists, fibrinogen binding was significantly reduced after clopidogrel by 70%, 64%, and 81% (all p < 0.0001) and again further reduced with eptifibatide by 90%, 95%, and 69% (all p < 0.0001). Eptifibatide 159-171 fibrinogen beta chain Homo sapiens 24-34 14736431-8 2004 CONCLUSIONS: The activated GP IIb/IIIa expression and fibrinogen binding findings indicate that eptifibatide provides significant potent antiplatelet activity above aspirin and clopidogrel, suggesting additive immediate protection in the treatment of NSTEMI. Eptifibatide 96-108 fibrinogen beta chain Homo sapiens 54-64 15049721-4 2004 Increased platelet thromboxane production as well as activation of platelet receptors for fibrinogen and or adenosine diphosphate (ADP) are often present, and can be treated with aspirin (acetylsalicylic acid) and/or receptor blockers. Aspirin 188-208 fibrinogen beta chain Homo sapiens 90-100 14766377-6 2004 Lp(a) inhibited 125I-labeled fibrinogen binding to collagen-stimulated platelets with an IC-50 of less than 5 mg/dl. Iodine-125 16-20 fibrinogen beta chain Homo sapiens 29-39 14580906-6 2004 The adsorption of proteins such as albumin, fibrinogen, IgG and human plasma proteins on the poly-PC surfaces were significantly reduced, in vitro. poly-pc 93-100 fibrinogen beta chain Homo sapiens 44-54 14707412-9 2004 Stepwise multiple linear regression analysis showed a significant association of enhanced L-arginine reactivity with previous stroke/TIA (p < 0.001) and elevated fibrinogen levels (p < 0.05) but not with age, IMT, hypertension, cholesterol or other risk factors. Arginine 90-100 fibrinogen beta chain Homo sapiens 165-175 16734113-6 2004 Plasma fibrinogen level was modestly reduced by BPL treatment, while it remained unchanged by BEI treatment. Propiolactone 48-51 fibrinogen beta chain Homo sapiens 7-17 15318794-0 2004 Platelet adhesion to radiofrequency glow-discharge-deposited fluorocarbon polymers preadsorbed with selectively depleted plasmas show the primary role of fibrinogen. Fluorocarbon Polymers 61-82 fibrinogen beta chain Homo sapiens 154-164 15318794-1 2004 Fluorocarbon radio-frequency glow-discharge (RFGD) treatment has previously been shown to cause decreased platelet adhesion despite the presence of adsorbed fibrinogen on the surfaces. Fluorocarbons 0-12 fibrinogen beta chain Homo sapiens 157-167 15318794-7 2004 Fibrinogen was found to play a decisive role in mediating platelet adhesion to the fluorocarbon surfaces contacting plasma. Fluorocarbons 83-95 fibrinogen beta chain Homo sapiens 0-10 17265611-9 2004 There was also a significant association between dietary intake, SBP, DBP, weight, BMI, percent body fat and waist, fibrinogen and factor VII activity and TC, TG, HDL-c, LDL-c, LDL/HDL, Lp (a) and APB (P < 0.05). Technetium 155-157 fibrinogen beta chain Homo sapiens 116-126 14717979-12 2004 A synergistic inhibitory effect of RANTES and prostaglandin E1 used at subthreshold concentrations, on SDF-1 alpha-induced aggregation and SDF-1 alpha-induced fibrinogen binding to platelets was observed, which may suggest involvement of RANTES in a cAMP-dependent signal transduction pathway. Alprostadil 46-62 fibrinogen beta chain Homo sapiens 159-169 15080557-7 2004 Multiple regression analysis showed that postoperative changes in fibrinogen (deltaFIB, micromol/l) were simultaneously related to the number of resected liver segments (NSEG), total bilirubin (BIL, micromol/l), aspartate aminotransferase (AST, U/l, n.v. 5-45), albumin (ALB, g/l), prothrombin activity (PA, % of standard reference), age (AGE, years) and basal preoperative fibrinogen (PFIB, micromol/l): deltaFIB = -0.51(NSEG) - 0.71(Log(n)BIL) - 0.74(Log(n)AST) + 0.11(ALB) + 0.09(PA) - 0.06(AGE) - 0.55(PFIB) + 7.74 (n=362, r2=0.68, p<0.001). Bilirubin 183-192 fibrinogen beta chain Homo sapiens 66-76 15080557-7 2004 Multiple regression analysis showed that postoperative changes in fibrinogen (deltaFIB, micromol/l) were simultaneously related to the number of resected liver segments (NSEG), total bilirubin (BIL, micromol/l), aspartate aminotransferase (AST, U/l, n.v. 5-45), albumin (ALB, g/l), prothrombin activity (PA, % of standard reference), age (AGE, years) and basal preoperative fibrinogen (PFIB, micromol/l): deltaFIB = -0.51(NSEG) - 0.71(Log(n)BIL) - 0.74(Log(n)AST) + 0.11(ALB) + 0.09(PA) - 0.06(AGE) - 0.55(PFIB) + 7.74 (n=362, r2=0.68, p<0.001). Bilirubin 194-197 fibrinogen beta chain Homo sapiens 66-76 14717979-12 2004 A synergistic inhibitory effect of RANTES and prostaglandin E1 used at subthreshold concentrations, on SDF-1 alpha-induced aggregation and SDF-1 alpha-induced fibrinogen binding to platelets was observed, which may suggest involvement of RANTES in a cAMP-dependent signal transduction pathway. Cyclic AMP 250-254 fibrinogen beta chain Homo sapiens 159-169 15081565-0 2004 The viscosity of fibrinogen subfractions and of EDTA denatured fibrinogen do not differ from that of native fibrinogen. Edetic Acid 48-52 fibrinogen beta chain Homo sapiens 63-73 14755788-0 2004 Quantitative assessment of fibrinogen cross-linking by epsilon aminocaproic acid in patients with end-stage liver disease. Aminocaproic Acid 55-80 fibrinogen beta chain Homo sapiens 27-37 14755788-2 2004 We adapted chemical engineering tools used in polymerization studies to quantify fibrinogen cross-linking by plasma from liver transplant patients obtained before and after epsilon aminocaproic acid (EACA) therapy. Aminocaproic Acid 173-198 fibrinogen beta chain Homo sapiens 81-91 14755788-2 2004 We adapted chemical engineering tools used in polymerization studies to quantify fibrinogen cross-linking by plasma from liver transplant patients obtained before and after epsilon aminocaproic acid (EACA) therapy. Aminocaproic Acid 200-204 fibrinogen beta chain Homo sapiens 81-91 14755788-3 2004 A target fluorescein isothiocyanate-fibrinogen (FITC-fibrinogen) molecule was constructed; it fluoresces in a quantifiable pattern when in solution, and undergoes cross-linking in the presence of plasmin inhibitors. Fluorescein 9-20 fibrinogen beta chain Homo sapiens 36-46 14755788-3 2004 A target fluorescein isothiocyanate-fibrinogen (FITC-fibrinogen) molecule was constructed; it fluoresces in a quantifiable pattern when in solution, and undergoes cross-linking in the presence of plasmin inhibitors. Fluorescein 9-20 fibrinogen beta chain Homo sapiens 53-63 14755788-6 2004 Cross-linking of FITC-fibrinogen by patient plasma, before and after EACA therapy, was assessed using fluorescence spectrometry. Fluorescein-5-isothiocyanate 17-21 fibrinogen beta chain Homo sapiens 22-32 14755788-8 2004 When the fibrinogen-FITC target was assayed without plasma in the presence of EACA at concentrations that bracket therapeutic levels (100 and 400 microg/ml), significant fluorescence quenching (target FITC-fibrinogen cross-linking) was achieved. Fluorescein-5-isothiocyanate 20-24 fibrinogen beta chain Homo sapiens 9-19 14755788-8 2004 When the fibrinogen-FITC target was assayed without plasma in the presence of EACA at concentrations that bracket therapeutic levels (100 and 400 microg/ml), significant fluorescence quenching (target FITC-fibrinogen cross-linking) was achieved. Fluorescein-5-isothiocyanate 20-24 fibrinogen beta chain Homo sapiens 206-216 14755788-8 2004 When the fibrinogen-FITC target was assayed without plasma in the presence of EACA at concentrations that bracket therapeutic levels (100 and 400 microg/ml), significant fluorescence quenching (target FITC-fibrinogen cross-linking) was achieved. Fluorescein-5-isothiocyanate 201-205 fibrinogen beta chain Homo sapiens 9-19 14755788-8 2004 When the fibrinogen-FITC target was assayed without plasma in the presence of EACA at concentrations that bracket therapeutic levels (100 and 400 microg/ml), significant fluorescence quenching (target FITC-fibrinogen cross-linking) was achieved. Fluorescein-5-isothiocyanate 201-205 fibrinogen beta chain Homo sapiens 206-216 14755788-9 2004 These results suggest that fibrinogen-FITC fluorescence is sensitive enough to detect EACA activity in clinically relevant ranges, but that EACA given in usual doses is insufficient to promote fibrinogen cross-linking in patients with end-stage liver disease. Fluorescein-5-isothiocyanate 38-42 fibrinogen beta chain Homo sapiens 27-37 14981803-4 2004 PT was correlated with the levels of plasma BG and apo E (r = 0.500, P = 0.012), the levels of Fg was positively correlated with BG (r = 0.598, P = 0.000), and BPC of HTG subjects was negatively correlated with TG (r = -0.489, P < 0.05). Thioguanine 168-170 fibrinogen beta chain Homo sapiens 95-97 15183042-9 2004 FK633 inhibited platelet aggregation and fibrinogen binding to platelets throughout recirculation. ((4-(4-amidinophenoxy)butanoyl)aspartyl)valine 0-5 fibrinogen beta chain Homo sapiens 41-51 14691567-5 2004 Higher concentrations (>120 micro M of Cbeta or preCgamma) induced fibrinogen precipitation even without thrombin. cbeta 42-47 fibrinogen beta chain Homo sapiens 70-80 14691567-8 2004 Sepharose beads covalently coated with either whole fibrinogen or Haptides (SB-Fib or SB-Haptide) highly adsorbed free (FITC) Haptides. Sepharose 0-9 fibrinogen beta chain Homo sapiens 52-62 14691567-8 2004 Sepharose beads covalently coated with either whole fibrinogen or Haptides (SB-Fib or SB-Haptide) highly adsorbed free (FITC) Haptides. Fluorescein-5-isothiocyanate 120-124 fibrinogen beta chain Homo sapiens 52-62 15081565-0 2004 The viscosity of fibrinogen subfractions and of EDTA denatured fibrinogen do not differ from that of native fibrinogen. Edetic Acid 48-52 fibrinogen beta chain Homo sapiens 63-73 15183042-12 2004 These results suggest that FK633 inhibits the amplification loop by reducing the binding of fibrinogen to glycoprotein IIb/IIIa and platelet aggregation. ((4-(4-amidinophenoxy)butanoyl)aspartyl)valine 27-32 fibrinogen beta chain Homo sapiens 92-102 15081565-4 2004 The viscosity of plasma is usually determined in ethylenediaminetetra-acetic acid (EDTA) plasma at 37 degrees C. Under such conditions the clotting properties of fibrinogen is affected due to denaturation. Edetic Acid 49-81 fibrinogen beta chain Homo sapiens 162-172 15332580-5 2004 A statistically significant correlation exists between homocysteine serum levels and acute phase proteins (C-reactive protein, fibrinogen) in patients with unstable angina. Homocysteine 55-67 fibrinogen beta chain Homo sapiens 127-137 15381393-7 2004 Cells spreading on immobilized soluble fibrin were blocked by the exogenous addition of soluble fibrin and glycine-arginine-glycine-aspartic acid-serine-phenylalanine (GRGDSP)-synthetic peptide but not by the addition of fibrinogen or fibrin monomer. Arginine 115-123 fibrinogen beta chain Homo sapiens 221-231 15381393-7 2004 Cells spreading on immobilized soluble fibrin were blocked by the exogenous addition of soluble fibrin and glycine-arginine-glycine-aspartic acid-serine-phenylalanine (GRGDSP)-synthetic peptide but not by the addition of fibrinogen or fibrin monomer. Glycine 124-131 fibrinogen beta chain Homo sapiens 221-231 15381393-7 2004 Cells spreading on immobilized soluble fibrin were blocked by the exogenous addition of soluble fibrin and glycine-arginine-glycine-aspartic acid-serine-phenylalanine (GRGDSP)-synthetic peptide but not by the addition of fibrinogen or fibrin monomer. Aspartic Acid 132-145 fibrinogen beta chain Homo sapiens 221-231 15381393-7 2004 Cells spreading on immobilized soluble fibrin were blocked by the exogenous addition of soluble fibrin and glycine-arginine-glycine-aspartic acid-serine-phenylalanine (GRGDSP)-synthetic peptide but not by the addition of fibrinogen or fibrin monomer. Phenylalanine 153-166 fibrinogen beta chain Homo sapiens 221-231 15081565-4 2004 The viscosity of plasma is usually determined in ethylenediaminetetra-acetic acid (EDTA) plasma at 37 degrees C. Under such conditions the clotting properties of fibrinogen is affected due to denaturation. Edetic Acid 83-87 fibrinogen beta chain Homo sapiens 162-172 15081565-6 2004 Therefore, we have also investigated the effects of EDTA on the viscosity of fibrinogen. Edetic Acid 52-56 fibrinogen beta chain Homo sapiens 77-87 15743106-17 2004 Tibolone lowers lipoprotein(a), fibrinogen, and plasminogen activator inhibitor-1 levels and improves glucose tolerance, insulin sensitivity, and endothelial function; however, it also lowers high-density lipoprotein cholesterol by >20%. tibolone 0-8 fibrinogen beta chain Homo sapiens 32-42 15081565-7 2004 MATERIALS AND METHODS: Purified fibrinogen was obtained by beta-alanine precipitation of plasma from healthy donors. beta-Alanine 59-71 fibrinogen beta chain Homo sapiens 32-42 15081565-8 2004 Separation of the fibrinogen fractions was performed by gradual precipitation of purified fibrinogen by ammonium sulphate. Ammonium Sulfate 104-121 fibrinogen beta chain Homo sapiens 18-28 15081565-8 2004 Separation of the fibrinogen fractions was performed by gradual precipitation of purified fibrinogen by ammonium sulphate. Ammonium Sulfate 104-121 fibrinogen beta chain Homo sapiens 90-100 15081565-11 2004 A substantial prolongation of the thrombin clotting time was observed in the fibrinogen solution containing EDTA at 37 degrees C compared to 20 degrees C. However, the viscosity of EDTA anticoagulated purified fibrinogen and plasma samples did not differ from that of heparin anticoagulated samples. Edetic Acid 108-112 fibrinogen beta chain Homo sapiens 77-87 15081565-11 2004 A substantial prolongation of the thrombin clotting time was observed in the fibrinogen solution containing EDTA at 37 degrees C compared to 20 degrees C. However, the viscosity of EDTA anticoagulated purified fibrinogen and plasma samples did not differ from that of heparin anticoagulated samples. Edetic Acid 108-112 fibrinogen beta chain Homo sapiens 210-220 15081565-11 2004 A substantial prolongation of the thrombin clotting time was observed in the fibrinogen solution containing EDTA at 37 degrees C compared to 20 degrees C. However, the viscosity of EDTA anticoagulated purified fibrinogen and plasma samples did not differ from that of heparin anticoagulated samples. Edetic Acid 181-185 fibrinogen beta chain Homo sapiens 77-87 15081565-11 2004 A substantial prolongation of the thrombin clotting time was observed in the fibrinogen solution containing EDTA at 37 degrees C compared to 20 degrees C. However, the viscosity of EDTA anticoagulated purified fibrinogen and plasma samples did not differ from that of heparin anticoagulated samples. Edetic Acid 181-185 fibrinogen beta chain Homo sapiens 210-220 15081565-11 2004 A substantial prolongation of the thrombin clotting time was observed in the fibrinogen solution containing EDTA at 37 degrees C compared to 20 degrees C. However, the viscosity of EDTA anticoagulated purified fibrinogen and plasma samples did not differ from that of heparin anticoagulated samples. Heparin 268-275 fibrinogen beta chain Homo sapiens 77-87 14703415-4 2003 RESULTS: The sequencing results of the proband revealed compound 2 heterozygous mutations in fibrinogen FGA gene, one being a splice mutation (g.1892-1899delAGTAorGTAA) in the boundary between exon3 and intron3 of the FGA gene and traced back to her patriline and the other being a 1,238 bp large deletion (g.1978-3215) in the same gene and originating from her matriline. patriline 250-259 fibrinogen beta chain Homo sapiens 93-103 14624512-0 2003 Variations in the ability of adsorbed fibrinogen to mediate platelet adhesion to polystyrene-based materials: a multivariate statistical analysis of antibody binding to the platelet binding sites of fibrinogen. Polystyrenes 81-92 fibrinogen beta chain Homo sapiens 38-48 14740347-10 2003 The indices of renal functions, i.e. albuminuria (r = 0.37; p < 0.0001) and serum creatinine (r = 0.22; p = 0.015), significantly correlated with fibrinogen levels. Creatinine 85-95 fibrinogen beta chain Homo sapiens 149-159 14643229-0 2003 Study of the adsorption of fibrinogen on gold-coated silicon wafer by an impedance method. Silicon 53-60 fibrinogen beta chain Homo sapiens 27-37 14643229-3 2003 The ellipsometry experiment showed that the adsorption of fibrinogen onto the gold-coated silicon wafer surface arrived at a saturated state when the adsorption time exceeded 50 min. Silicon 90-97 fibrinogen beta chain Homo sapiens 58-68 14703415-4 2003 RESULTS: The sequencing results of the proband revealed compound 2 heterozygous mutations in fibrinogen FGA gene, one being a splice mutation (g.1892-1899delAGTAorGTAA) in the boundary between exon3 and intron3 of the FGA gene and traced back to her patriline and the other being a 1,238 bp large deletion (g.1978-3215) in the same gene and originating from her matriline. matriline 362-371 fibrinogen beta chain Homo sapiens 93-103 14606874-3 2003 We investigated the influence of basal and stress levels of epinephrine and beta-endorphin on the conformation of fibrinogen (Fbg), both in saline solution (under physiological conditions) and after its adsorption to polyethylene (PE), by FT-IR spectroscopy. Sodium Chloride 140-146 fibrinogen beta chain Homo sapiens 114-124 14690763-10 2003 The stability of fibrinogen, expressed in thermodynamic parameters, has shown that the loosening of the structure takes place under ethanol and urea denaturation. Ethanol 132-139 fibrinogen beta chain Homo sapiens 17-27 14690763-10 2003 The stability of fibrinogen, expressed in thermodynamic parameters, has shown that the loosening of the structure takes place under ethanol and urea denaturation. Urea 144-148 fibrinogen beta chain Homo sapiens 17-27 14652640-4 2003 Total alcohol consumption showed a significant positive dose-response relationship with high density lipoprotein cholesterol (HDL-C), coagulation factor IX, haematocrit, blood viscosity, and tissue plasminogen (t-PA) antigen, and an inverse dose-response relationship with insulin, fibrinogen, von Willebrand factor (vWF) and triglycerides after adjustment for possible confounders. Alcohols 6-13 fibrinogen beta chain Homo sapiens 282-292 14642684-8 2003 RESULTS: Rosiglitazone treatment resulted in a significant reduction in E-selectin (p = 0.03), von Willebrand factor (p = 0.007), C-reactive protein (p < 0.001), fibrinogen (p = 0.003) and the homeostasis model of insulin resistance index (p = 0.02), compared with placebo. Rosiglitazone 9-22 fibrinogen beta chain Homo sapiens 165-175 15006256-0 2003 Transition to raloxifene with and without low-dose estrogen therapy in postmenopausal women: effects on serum lipids and fibrinogen - a pilot study. Raloxifene Hydrochloride 14-24 fibrinogen beta chain Homo sapiens 121-131 14606874-3 2003 We investigated the influence of basal and stress levels of epinephrine and beta-endorphin on the conformation of fibrinogen (Fbg), both in saline solution (under physiological conditions) and after its adsorption to polyethylene (PE), by FT-IR spectroscopy. Polyethylene 217-229 fibrinogen beta chain Homo sapiens 114-124 14606874-5 2003 Epinephrine was found to affect Fbg conformation and to increase platelet adhesion to PE at stress level. Epinephrine 0-11 fibrinogen beta chain Homo sapiens 32-35 14606874-8 2003 The response of platelets was affected by the stress status of donors through the influence of epinephrine on Fbg conformation. Epinephrine 95-106 fibrinogen beta chain Homo sapiens 110-113 14605073-7 2003 Although not consistently shown, severity of OSA (ie, apnea-hypopnea index) and plasma epinephrine were independent predictors of platelet activity, and average minimal oxygen saturation was an independent predictor of fibrinogen. Oxygen 169-175 fibrinogen beta chain Homo sapiens 219-229 14566784-5 2003 We found that the ROS-production is 2 to 3 times higher in neutrophils on immunoglobulin G (IgG)-coated surfaces than in cells interacting with albumin- or fibrinogen-coated surfaces. Reactive Oxygen Species 18-21 fibrinogen beta chain Homo sapiens 156-166 14708628-7 2003 Surprisingly, fibrin and fibrinogen caused significant detachment of keratinocytes which was prevented by the addition of calcium. Calcium 122-129 fibrinogen beta chain Homo sapiens 25-35 14566784-7 2003 The presence of platelets markedly increased the extracellular generation of ROS, mainly in neutrophils interacting with IgG- or fibrinogen-coated surfaces whereas the intracellular production was only modestly affected. Reactive Oxygen Species 77-80 fibrinogen beta chain Homo sapiens 129-139 14567919-3 2003 SdrG is a cell wall-anchored adhesin from Staphylococcus epidermidis that binds to the Bbeta chain of human fibrinogen (Fg) and is necessary and sufficient for bacterial attachment to Fg-coated biomaterials. sdrg 0-4 fibrinogen beta chain Homo sapiens 108-118 14566784-9 2003 Platelets markedly amplified the anti-phosphotyrosine staining on both fibrinogen- and IgG-coated surfaces whereas the low level of tyrosine phosphorylation in neutrophils on albumin-coated surfaces was not further elevated by platelets. Phosphotyrosine 38-53 fibrinogen beta chain Homo sapiens 71-81 14566784-9 2003 Platelets markedly amplified the anti-phosphotyrosine staining on both fibrinogen- and IgG-coated surfaces whereas the low level of tyrosine phosphorylation in neutrophils on albumin-coated surfaces was not further elevated by platelets. Tyrosine 45-53 fibrinogen beta chain Homo sapiens 71-81 14624393-0 2003 Impact of margarine enriched with plant sterols on blood lipids, platelet function, and fibrinogen level in young men. Margarine 10-19 fibrinogen beta chain Homo sapiens 88-98 14624393-8 2003 Both types of margarine increased the concentration of Fb (P<.001), without exceeding the normal medium value of 2.8 g/L. Margarine 14-23 fibrinogen beta chain Homo sapiens 55-57 14606683-1 2003 Using a combination of Cohn ethanol fractionation, virus inactivation, glycine and sodium chloride precipitation, and lysine-Sepharose affinity chromatography, a unique and rapid simplified method was developed to obtain highly purified fibrinogen for diagnostic use with both biological (Clauss method) and immunological (Jacobsson method) activity. Sodium Chloride 83-98 fibrinogen beta chain Homo sapiens 237-247 14606683-1 2003 Using a combination of Cohn ethanol fractionation, virus inactivation, glycine and sodium chloride precipitation, and lysine-Sepharose affinity chromatography, a unique and rapid simplified method was developed to obtain highly purified fibrinogen for diagnostic use with both biological (Clauss method) and immunological (Jacobsson method) activity. Lysine 118-124 fibrinogen beta chain Homo sapiens 237-247 14606683-1 2003 Using a combination of Cohn ethanol fractionation, virus inactivation, glycine and sodium chloride precipitation, and lysine-Sepharose affinity chromatography, a unique and rapid simplified method was developed to obtain highly purified fibrinogen for diagnostic use with both biological (Clauss method) and immunological (Jacobsson method) activity. Sepharose 125-134 fibrinogen beta chain Homo sapiens 237-247 14558825-1 2003 The molecular level details of the displacement of surface adsorbed fibrinogen from silica substrates were studied by atomic force microscopy, immunochemical assays, fluorescence microscopy, and vibrational sum frequency spectroscopy. Silicon Dioxide 84-90 fibrinogen beta chain Homo sapiens 68-78 14567919-3 2003 SdrG is a cell wall-anchored adhesin from Staphylococcus epidermidis that binds to the Bbeta chain of human fibrinogen (Fg) and is necessary and sufficient for bacterial attachment to Fg-coated biomaterials. sdrg 0-4 fibrinogen beta chain Homo sapiens 120-122 14567919-3 2003 SdrG is a cell wall-anchored adhesin from Staphylococcus epidermidis that binds to the Bbeta chain of human fibrinogen (Fg) and is necessary and sufficient for bacterial attachment to Fg-coated biomaterials. sdrg 0-4 fibrinogen beta chain Homo sapiens 184-186 14567919-3 2003 SdrG is a cell wall-anchored adhesin from Staphylococcus epidermidis that binds to the Bbeta chain of human fibrinogen (Fg) and is necessary and sufficient for bacterial attachment to Fg-coated biomaterials. bbeta 87-92 fibrinogen beta chain Homo sapiens 108-118 14567919-3 2003 SdrG is a cell wall-anchored adhesin from Staphylococcus epidermidis that binds to the Bbeta chain of human fibrinogen (Fg) and is necessary and sufficient for bacterial attachment to Fg-coated biomaterials. bbeta 87-92 fibrinogen beta chain Homo sapiens 120-122 14517875-4 2003 Trehalose protection had shown some promise for ToF-SIMS analysis in our previous study and was further examined with the model protein fibrinogen in this study. Trehalose 0-9 fibrinogen beta chain Homo sapiens 136-146 14640259-7 2003 RESULTS: The platelets from women bound more fibrinogen in response to low and high concentrations of adenosine diphosphate. Adenosine Diphosphate 102-123 fibrinogen beta chain Homo sapiens 45-55 14517875-5 2003 Using the combination of principal component analysis (PCA) and static ToF-SIMS analysis, we found that trehalose protection could reduce the conformation change of fibrinogen upon drying, and prevent it from unfolding and exposing hydrophobic domains. Trehalose 104-113 fibrinogen beta chain Homo sapiens 165-175 15348529-0 2003 Blood response to plasticized poly(vinyl chloride): dependence of fibrinogen adsorption on plasticizer selection and surface plasticizer level. Polyvinyl Chloride 30-50 fibrinogen beta chain Homo sapiens 66-76 15348529-5 2003 The alteration of surface plasticizer level was achieved by a methanol-cleaning treatment with a variety of cleaning times and the fibrinogen adsorption on plasticized PVC decreases with the reduction of surface plasticizer level. Methanol 62-70 fibrinogen beta chain Homo sapiens 131-141 12963038-5 2003 Unlike other typical RGD-disintegrins, the recombinant non-RGD disintegrin, halydin, inhibited platelet aggregation by suppressing platelet adhesion to collagen rather than by blocking fibrinogen binding to glycoprotein (GP) IIb-IIIa on the platelet surface. halydin 76-83 fibrinogen beta chain Homo sapiens 185-195 14631552-8 2003 The results, which show correlation between the plasma fibrinogen and triglyceride levels, are presented. Triglycerides 70-82 fibrinogen beta chain Homo sapiens 55-65 12791669-3 2003 We have shown that disulfide exchange is necessary for platelet adhesion to fibrinogen, fibronectin, and collagen. Disulfides 19-28 fibrinogen beta chain Homo sapiens 76-86 12889011-6 2003 Fibrinogen-adherent platelets exposed to thrombin generated the significantly highest exposure of CD62P and release of PF4, ADP, and ATP. Adenosine Diphosphate 124-127 fibrinogen beta chain Homo sapiens 0-10 12913789-4 2003 Fibrinogen and thrombospondin have been found to bind serotonin-conjugated proteins and thereby provide the requisite link for stabilization of serotonin-derivatized, procoagulant proteins on COAT platelets. Serotonin 54-63 fibrinogen beta chain Homo sapiens 0-10 12913789-4 2003 Fibrinogen and thrombospondin have been found to bind serotonin-conjugated proteins and thereby provide the requisite link for stabilization of serotonin-derivatized, procoagulant proteins on COAT platelets. Serotonin 144-153 fibrinogen beta chain Homo sapiens 0-10 12913789-5 2003 SUMMARY: Multivalent interactions, resulting from traditional receptor interactions and binding of conjugated serotonin by fibrinogen and thrombospondin, result in exceptionally strong retention of procoagulant alpha-granule proteins on the surface of COAT platelets. Serotonin 110-119 fibrinogen beta chain Homo sapiens 123-133 12957313-10 2003 Immobilized EFE-II degrades not only the Aalpha chain of fibrinogen in the C-terminal region (like human neutrophil elastase, HNE), but also in the N-terminal region at the Val(21)-Glu(22) site. Glutamic Acid 181-184 fibrinogen beta chain Homo sapiens 57-67 12918056-2 2003 First, the kinetic behavior of a range of human fibrinogen (Fib) adsorbed onto polystyrene (PS) films was investigated by using a reflectometry interference spectroscopy setup. Polystyrenes 79-90 fibrinogen beta chain Homo sapiens 48-58 12918056-2 2003 First, the kinetic behavior of a range of human fibrinogen (Fib) adsorbed onto polystyrene (PS) films was investigated by using a reflectometry interference spectroscopy setup. Polystyrenes 79-90 fibrinogen beta chain Homo sapiens 60-63 12918056-2 2003 First, the kinetic behavior of a range of human fibrinogen (Fib) adsorbed onto polystyrene (PS) films was investigated by using a reflectometry interference spectroscopy setup. Polystyrenes 92-94 fibrinogen beta chain Homo sapiens 48-58 12918056-2 2003 First, the kinetic behavior of a range of human fibrinogen (Fib) adsorbed onto polystyrene (PS) films was investigated by using a reflectometry interference spectroscopy setup. Polystyrenes 92-94 fibrinogen beta chain Homo sapiens 60-63 14501606-6 2003 Of the markers reflecting coagulation and fibrinolysis, plasma fibrinogen was significantly reduced in the 60- and 90-mg groups of ospemifene (8.7% and 8.5%, respectively) when compared with the placebo group. Ospemifene 131-141 fibrinogen beta chain Homo sapiens 63-73 14524041-7 2003 Following binding to a peptide (Gly-Pro-Arg-Pro-Lys), fibrinogen and fibrin were specifically removed from the patient"s plasma: her fibrinogen concentration was lowered from an original mean level of 310 mg/dl (SD +/- 104 mg/dl) to 136 mg/dl (SD +/- 54 mg/dl), and there was no return to the baseline concentration by the time of the next fibrinogen adsorption session. Glycine 32-35 fibrinogen beta chain Homo sapiens 54-64 14524041-7 2003 Following binding to a peptide (Gly-Pro-Arg-Pro-Lys), fibrinogen and fibrin were specifically removed from the patient"s plasma: her fibrinogen concentration was lowered from an original mean level of 310 mg/dl (SD +/- 104 mg/dl) to 136 mg/dl (SD +/- 54 mg/dl), and there was no return to the baseline concentration by the time of the next fibrinogen adsorption session. Glycine 32-35 fibrinogen beta chain Homo sapiens 133-143 14524041-7 2003 Following binding to a peptide (Gly-Pro-Arg-Pro-Lys), fibrinogen and fibrin were specifically removed from the patient"s plasma: her fibrinogen concentration was lowered from an original mean level of 310 mg/dl (SD +/- 104 mg/dl) to 136 mg/dl (SD +/- 54 mg/dl), and there was no return to the baseline concentration by the time of the next fibrinogen adsorption session. Glycine 32-35 fibrinogen beta chain Homo sapiens 133-143 14524041-7 2003 Following binding to a peptide (Gly-Pro-Arg-Pro-Lys), fibrinogen and fibrin were specifically removed from the patient"s plasma: her fibrinogen concentration was lowered from an original mean level of 310 mg/dl (SD +/- 104 mg/dl) to 136 mg/dl (SD +/- 54 mg/dl), and there was no return to the baseline concentration by the time of the next fibrinogen adsorption session. prolylarginine 36-43 fibrinogen beta chain Homo sapiens 54-64 14524041-7 2003 Following binding to a peptide (Gly-Pro-Arg-Pro-Lys), fibrinogen and fibrin were specifically removed from the patient"s plasma: her fibrinogen concentration was lowered from an original mean level of 310 mg/dl (SD +/- 104 mg/dl) to 136 mg/dl (SD +/- 54 mg/dl), and there was no return to the baseline concentration by the time of the next fibrinogen adsorption session. prolylarginine 36-43 fibrinogen beta chain Homo sapiens 133-143 14524041-7 2003 Following binding to a peptide (Gly-Pro-Arg-Pro-Lys), fibrinogen and fibrin were specifically removed from the patient"s plasma: her fibrinogen concentration was lowered from an original mean level of 310 mg/dl (SD +/- 104 mg/dl) to 136 mg/dl (SD +/- 54 mg/dl), and there was no return to the baseline concentration by the time of the next fibrinogen adsorption session. prolylarginine 36-43 fibrinogen beta chain Homo sapiens 133-143 14524041-7 2003 Following binding to a peptide (Gly-Pro-Arg-Pro-Lys), fibrinogen and fibrin were specifically removed from the patient"s plasma: her fibrinogen concentration was lowered from an original mean level of 310 mg/dl (SD +/- 104 mg/dl) to 136 mg/dl (SD +/- 54 mg/dl), and there was no return to the baseline concentration by the time of the next fibrinogen adsorption session. Pro-Lys 44-51 fibrinogen beta chain Homo sapiens 133-143 14524041-7 2003 Following binding to a peptide (Gly-Pro-Arg-Pro-Lys), fibrinogen and fibrin were specifically removed from the patient"s plasma: her fibrinogen concentration was lowered from an original mean level of 310 mg/dl (SD +/- 104 mg/dl) to 136 mg/dl (SD +/- 54 mg/dl), and there was no return to the baseline concentration by the time of the next fibrinogen adsorption session. Pro-Lys 44-51 fibrinogen beta chain Homo sapiens 133-143 12842247-0 2003 Relation of C-reactive protein and fibrinogen to coronary artery calcium in subjects with systemic hypertension. Calcium 65-72 fibrinogen beta chain Homo sapiens 35-45 12791602-1 2003 Increased synthesis rate of fibrinogen, an independent risk factor for cardiovascular disease, was recently reported in obese insulin-resistant female adolescents with chronic elevated nonesterified fatty acids (NEFA). Fatty Acids, Nonesterified 185-210 fibrinogen beta chain Homo sapiens 28-38 12791602-1 2003 Increased synthesis rate of fibrinogen, an independent risk factor for cardiovascular disease, was recently reported in obese insulin-resistant female adolescents with chronic elevated nonesterified fatty acids (NEFA). Fatty Acids, Nonesterified 212-216 fibrinogen beta chain Homo sapiens 28-38 12791602-5 2003 Plasma fibrinogen was isolated with the beta-alanine method, and fibrinogen-related [13C]leucine enrichment was analyzed by GC-CIRMS. 13c 85-88 fibrinogen beta chain Homo sapiens 65-75 12791602-5 2003 Plasma fibrinogen was isolated with the beta-alanine method, and fibrinogen-related [13C]leucine enrichment was analyzed by GC-CIRMS. Leucine 89-96 fibrinogen beta chain Homo sapiens 65-75 12791602-11 2003 NEFA contributes to short-term regulation of fibrinogen FSR in healthy volunteers under unchanged hormonal status, leucine metabolism, and overall amino acid catabolism. Leucine 115-122 fibrinogen beta chain Homo sapiens 45-55 12801518-5 2003 PEI showed no effect on thrombin amidolytic activity, suggesting that the blockade of thrombin interaction with FBG could account for the inhibition on fibrin formation. Polyethyleneimine 0-3 fibrinogen beta chain Homo sapiens 112-115 12799188-2 2003 We describe 19- to 21-mer cell-binding (haptotactic) peptides from the C-termini of fibrinogen beta-chain (Cbeta), the extended alphaE chain, and near the C-terminal of the gamma-chain. cbeta 107-112 fibrinogen beta chain Homo sapiens 84-94 12802486-9 2003 Following incubation with propofol, platelets showed reduced binding of fibrinogen in the unstimulated and ADP-stimulated blood samples as well as a lower percentage of platelets with bound fibrinogen. Propofol 26-34 fibrinogen beta chain Homo sapiens 72-82 12802486-9 2003 Following incubation with propofol, platelets showed reduced binding of fibrinogen in the unstimulated and ADP-stimulated blood samples as well as a lower percentage of platelets with bound fibrinogen. Propofol 26-34 fibrinogen beta chain Homo sapiens 190-200 12802486-9 2003 Following incubation with propofol, platelets showed reduced binding of fibrinogen in the unstimulated and ADP-stimulated blood samples as well as a lower percentage of platelets with bound fibrinogen. Adenosine Diphosphate 107-110 fibrinogen beta chain Homo sapiens 72-82 12802486-13 2003 We suggest that this effect is due to an inhibition of fibrinogen-binding to platelets by propofol. Propofol 90-98 fibrinogen beta chain Homo sapiens 55-65 12819249-15 2003 In conclusion, conversion from cyclosporine to tacrolimus in stable renal transplant patients has a beneficial effect on renal function, BP, serum concentration and atherogenic properties of serum lipids, and fibrinogen. Cyclosporine 31-43 fibrinogen beta chain Homo sapiens 209-219 12819249-15 2003 In conclusion, conversion from cyclosporine to tacrolimus in stable renal transplant patients has a beneficial effect on renal function, BP, serum concentration and atherogenic properties of serum lipids, and fibrinogen. Tacrolimus 47-57 fibrinogen beta chain Homo sapiens 209-219 12889011-6 2003 Fibrinogen-adherent platelets exposed to thrombin generated the significantly highest exposure of CD62P and release of PF4, ADP, and ATP. Adenosine Triphosphate 133-136 fibrinogen beta chain Homo sapiens 0-10 12876624-2 2003 Previously we reported a metabolic link between fibrinogen and lipid metabolism in that HepG2 cells that were programmed by transfection of Bbeta-fibrinogen cDNA to overexpress fibrinogen exhibited increased synthesis of cholesterol and increased secretion of apolipoprotein B. Cholesterol 221-232 fibrinogen beta chain Homo sapiens 48-58 12876624-2 2003 Previously we reported a metabolic link between fibrinogen and lipid metabolism in that HepG2 cells that were programmed by transfection of Bbeta-fibrinogen cDNA to overexpress fibrinogen exhibited increased synthesis of cholesterol and increased secretion of apolipoprotein B. Cholesterol 221-232 fibrinogen beta chain Homo sapiens 146-156 12876624-2 2003 Previously we reported a metabolic link between fibrinogen and lipid metabolism in that HepG2 cells that were programmed by transfection of Bbeta-fibrinogen cDNA to overexpress fibrinogen exhibited increased synthesis of cholesterol and increased secretion of apolipoprotein B. Cholesterol 221-232 fibrinogen beta chain Homo sapiens 146-156 12876624-3 2003 In this study we demonstrate that oxysterols, which participate in maintaining cholesterol homeostasis, also down regulate fibrinogen expression. Oxysterols 34-44 fibrinogen beta chain Homo sapiens 123-133 12876624-3 2003 In this study we demonstrate that oxysterols, which participate in maintaining cholesterol homeostasis, also down regulate fibrinogen expression. Cholesterol 79-90 fibrinogen beta chain Homo sapiens 123-133 12876624-4 2003 Treatment of HepG2 cells with 25-hydroxycholesterol lowered fibrinogen Aalpha, Bbeta and gamma mRNA levels and inhibited fibrinogen synthesis and secretion but had no effect on alpha1 -antitrypsin which, like fibrinogen, is an acute-phase protein. 25-hydroxycholesterol 30-51 fibrinogen beta chain Homo sapiens 60-70 12876624-4 2003 Treatment of HepG2 cells with 25-hydroxycholesterol lowered fibrinogen Aalpha, Bbeta and gamma mRNA levels and inhibited fibrinogen synthesis and secretion but had no effect on alpha1 -antitrypsin which, like fibrinogen, is an acute-phase protein. 25-hydroxycholesterol 30-51 fibrinogen beta chain Homo sapiens 121-131 12876624-4 2003 Treatment of HepG2 cells with 25-hydroxycholesterol lowered fibrinogen Aalpha, Bbeta and gamma mRNA levels and inhibited fibrinogen synthesis and secretion but had no effect on alpha1 -antitrypsin which, like fibrinogen, is an acute-phase protein. 25-hydroxycholesterol 30-51 fibrinogen beta chain Homo sapiens 121-131 12876624-5 2003 The inhibition of fibrinogen synthesis by oxysterols was maintained in interleukin-6 treated cells. Oxysterols 42-52 fibrinogen beta chain Homo sapiens 18-28 12876624-6 2003 Other oxysterols, that inhibit cholesterol synthesis by a feedback mechanism, also diminished fibrinogen expression in HepG2, rat H-4-II-E hepatoma cells and in primary human hepatocytes. Oxysterols 6-16 fibrinogen beta chain Homo sapiens 94-104 12876624-6 2003 Other oxysterols, that inhibit cholesterol synthesis by a feedback mechanism, also diminished fibrinogen expression in HepG2, rat H-4-II-E hepatoma cells and in primary human hepatocytes. Cholesterol 31-42 fibrinogen beta chain Homo sapiens 94-104 12783932-10 2003 Several blood biomarkers showed dose-response relationships with tamoxifen, including decreased insulin-like growth factor-I, increased sex hormone-binding globulin, and decreased low-density lipoprotein-cholesterol, ultrasensitive C-reactive protein, fibrinogen, and antithrombin-III levels. Tamoxifen 65-74 fibrinogen beta chain Homo sapiens 252-262 12729597-3 2003 Both serine-3 and serine-345 (both in Aalpha) of fibrinogen were clearly recognized. Serine 5-11 fibrinogen beta chain Homo sapiens 49-59 12729597-3 2003 Both serine-3 and serine-345 (both in Aalpha) of fibrinogen were clearly recognized. Serine 18-24 fibrinogen beta chain Homo sapiens 49-59 12765981-2 2003 We evaluated selective precipitation of fibrinogen with ethanol. Ethanol 56-63 fibrinogen beta chain Homo sapiens 40-50 12765981-5 2003 RESULTS: The fibrinogen band was effectively eliminated from the electrophoretic pattern in the plasma samples treated with ethanol at 100 mL/L and incubated in an ice bath for 15 min without a significant change in immunoglobulin concentrations. Ethanol 124-131 fibrinogen beta chain Homo sapiens 13-23 12765981-8 2003 CONCLUSIONS: Ethanol, 100 mL/L, can selectively precipitate fibrinogen without significantly interfering with the immunoglobulins. Ethanol 13-20 fibrinogen beta chain Homo sapiens 60-70 12761263-9 2003 Also, the plasma pentosidine content showed weak but significant positive correlations with CRP (Rho = 0.28; P < 0.0001), fibrinogen (Rho = 0.23; P < 0.01; n = 126), IL-6 (Rho = 0.22; P < 0.01; n = 169), and soluble vascular cellular adhesion molecule-1 (Rho = 0.38; P < 0.001; n = 74). pentosidine 17-28 fibrinogen beta chain Homo sapiens 125-135 12871315-5 2003 Upon interaction with fibrinogen, cholesterol accumulated at the tips of filopodia and at the leading edge of spreading cells. Cholesterol 34-45 fibrinogen beta chain Homo sapiens 22-32 12871315-9 2003 Disruption of rafts by depleting membrane cholesterol had no effect on platelet shape change but inhibited platelet spreading on fibrinogen and TRAP-induced aggregation. Cholesterol 42-53 fibrinogen beta chain Homo sapiens 129-139 12871327-10 2003 A second 31-year-old patient presented an extra band under non-reducing conditions, 30 kDa larger than HMW fibrinogen and reacting with antifibrinogen antibodies (fibrinogen Lozanne). lozanne 174-181 fibrinogen beta chain Homo sapiens 140-150 12871330-3 2003 Fibrinogen with bound FGF-2 was incubated with plasmin, the products characterized by SDS-PAGE, and the proliferative activity determined by (3)H-thymidine incorporation into endothelial cells. Sodium Dodecyl Sulfate 86-89 fibrinogen beta chain Homo sapiens 0-10 12871330-3 2003 Fibrinogen with bound FGF-2 was incubated with plasmin, the products characterized by SDS-PAGE, and the proliferative activity determined by (3)H-thymidine incorporation into endothelial cells. h-thymidine 144-155 fibrinogen beta chain Homo sapiens 0-10 12871330-8 2003 Immunoprecipitation of the digests with antifibrinogen antibody showed 70 +/- 8% of fibrinogen-bound FGF-2 in the presence of calcium but only 15 +/- 4% in its absence, indicating that cleavage of D1 to D2 and D3 is critical in binding. Calcium 126-133 fibrinogen beta chain Homo sapiens 44-54 12757384-3 2003 After adhesion to the mica surface, both liposomes without fibrinogen and liposomes with attached fibrinogen collapsed into patches. mica 22-26 fibrinogen beta chain Homo sapiens 59-69 14618797-3 2003 Convincing, statistically significant data have been obtained on a decline in the concentration of fibrinogen in those patients with acute viral myocarditis placed on a complex therapy, running a mild course of the disease, a mild one presenting with elevated indices for hemostasis, and moderately severe course (diclofenac, heparin, thiotriazoline) as well, in grave condition (prednisolone, heparin, thiotriazoline), that can help in choosing of patient treatment tactics. Diclofenac 314-324 fibrinogen beta chain Homo sapiens 99-109 14618797-3 2003 Convincing, statistically significant data have been obtained on a decline in the concentration of fibrinogen in those patients with acute viral myocarditis placed on a complex therapy, running a mild course of the disease, a mild one presenting with elevated indices for hemostasis, and moderately severe course (diclofenac, heparin, thiotriazoline) as well, in grave condition (prednisolone, heparin, thiotriazoline), that can help in choosing of patient treatment tactics. Heparin 326-333 fibrinogen beta chain Homo sapiens 99-109 14618797-3 2003 Convincing, statistically significant data have been obtained on a decline in the concentration of fibrinogen in those patients with acute viral myocarditis placed on a complex therapy, running a mild course of the disease, a mild one presenting with elevated indices for hemostasis, and moderately severe course (diclofenac, heparin, thiotriazoline) as well, in grave condition (prednisolone, heparin, thiotriazoline), that can help in choosing of patient treatment tactics. thiotriazoline 335-349 fibrinogen beta chain Homo sapiens 99-109 14618797-3 2003 Convincing, statistically significant data have been obtained on a decline in the concentration of fibrinogen in those patients with acute viral myocarditis placed on a complex therapy, running a mild course of the disease, a mild one presenting with elevated indices for hemostasis, and moderately severe course (diclofenac, heparin, thiotriazoline) as well, in grave condition (prednisolone, heparin, thiotriazoline), that can help in choosing of patient treatment tactics. Prednisolone 380-392 fibrinogen beta chain Homo sapiens 99-109 14618797-3 2003 Convincing, statistically significant data have been obtained on a decline in the concentration of fibrinogen in those patients with acute viral myocarditis placed on a complex therapy, running a mild course of the disease, a mild one presenting with elevated indices for hemostasis, and moderately severe course (diclofenac, heparin, thiotriazoline) as well, in grave condition (prednisolone, heparin, thiotriazoline), that can help in choosing of patient treatment tactics. Heparin 394-401 fibrinogen beta chain Homo sapiens 99-109 14618797-3 2003 Convincing, statistically significant data have been obtained on a decline in the concentration of fibrinogen in those patients with acute viral myocarditis placed on a complex therapy, running a mild course of the disease, a mild one presenting with elevated indices for hemostasis, and moderately severe course (diclofenac, heparin, thiotriazoline) as well, in grave condition (prednisolone, heparin, thiotriazoline), that can help in choosing of patient treatment tactics. thiotriazoline 403-417 fibrinogen beta chain Homo sapiens 99-109 12924614-2 2003 Through the application of heparin and lowering the pH value, lipoproteins and fibrinogen are reduced by 50-60%. Heparin 27-34 fibrinogen beta chain Homo sapiens 79-89 12707238-3 2003 METHODS AND RESULTS: We studied the properties of clots formed from purified Ala312 and Thr312 fibrinogen and found that Ala312 fibrinogen produces stiffer clots, associated with increased alpha chain cross-linking, as demonstrated by SDS-Page. Sodium Dodecyl Sulfate 235-238 fibrinogen beta chain Homo sapiens 128-138 12757384-3 2003 After adhesion to the mica surface, both liposomes without fibrinogen and liposomes with attached fibrinogen collapsed into patches. mica 22-26 fibrinogen beta chain Homo sapiens 98-108 12716802-2 2003 Univariate regression showed that fibrinogen levels were correlated with BMI (r = 0.15; P < 0.0001), HbA(1c) (r = 0.11; P = 0.0014), total cholesterol (r = 0.17; P < 0.0001), and LDL cholesterol (r = 0.16; P < 0.0001) in all patients. Cholesterol 142-153 fibrinogen beta chain Homo sapiens 34-44 12679863-2 2003 By using this technique, conformations of four proteins, viz., beta-casein, bovine serum albumin (BSA), lysozyme, and fibrinogen in the adsorbed state at the air-water interface have been studied. Water 162-167 fibrinogen beta chain Homo sapiens 118-128 12716802-2 2003 Univariate regression showed that fibrinogen levels were correlated with BMI (r = 0.15; P < 0.0001), HbA(1c) (r = 0.11; P = 0.0014), total cholesterol (r = 0.17; P < 0.0001), and LDL cholesterol (r = 0.16; P < 0.0001) in all patients. Cholesterol 189-200 fibrinogen beta chain Homo sapiens 34-44 12716802-3 2003 In men, but not women, waist-to-hip ratio (r = 0.20; P < 0.0001) and triglycerides (r = 0.13; P = 0.0047) also became powerful predictors of fibrinogen level; in women, but not men, fibrinogen was correlated with both diastolic (r = 0.16; P = 0.0011) and systolic (r = 0.11; P = 0.0241) blood pressure. Triglycerides 72-85 fibrinogen beta chain Homo sapiens 144-154 12686666-8 2003 RESULTS: HD patients on maintenance iron showed elevated carbonylated fibrinogen compared with healthy subjects. Iron 36-40 fibrinogen beta chain Homo sapiens 70-80 12717398-7 2003 Concurrent with an increase in the serum level of fibrinogen, transaminase levels declined significantly during treatment period, while bilirubin levels continued to drop for up to 20 days after the initiation of treatment (P <.05). Bilirubin 136-145 fibrinogen beta chain Homo sapiens 50-60 12686666-9 2003 During a HD session, carbonyls on fibrinogen further increased when 125 mg iron gluconate was administered, but no changes were detected with 62.5 mg iron gluconate or in the absence of iron. ferrous gluconate 75-89 fibrinogen beta chain Homo sapiens 34-44 12686666-9 2003 During a HD session, carbonyls on fibrinogen further increased when 125 mg iron gluconate was administered, but no changes were detected with 62.5 mg iron gluconate or in the absence of iron. Iron 75-79 fibrinogen beta chain Homo sapiens 34-44 12686666-11 2003 CONCLUSIONS: The significant acute increase in carbonylated fibrinogen with 125 mg iron gluconate suggests that this iron dose should be used with caution. ferrous gluconate 83-97 fibrinogen beta chain Homo sapiens 60-70 12686666-11 2003 CONCLUSIONS: The significant acute increase in carbonylated fibrinogen with 125 mg iron gluconate suggests that this iron dose should be used with caution. Iron 83-87 fibrinogen beta chain Homo sapiens 60-70 12686666-12 2003 As fibrinogen is highly susceptible to iron-induced oxidation in vivo, it may serve as a marker reflecting acute iron oxidative damage and as a tool in refinement of the existing clinical dose guidelines for intravenous iron therapy. Iron 39-43 fibrinogen beta chain Homo sapiens 3-13 12686666-12 2003 As fibrinogen is highly susceptible to iron-induced oxidation in vivo, it may serve as a marker reflecting acute iron oxidative damage and as a tool in refinement of the existing clinical dose guidelines for intravenous iron therapy. Iron 113-117 fibrinogen beta chain Homo sapiens 3-13 12686666-12 2003 As fibrinogen is highly susceptible to iron-induced oxidation in vivo, it may serve as a marker reflecting acute iron oxidative damage and as a tool in refinement of the existing clinical dose guidelines for intravenous iron therapy. Iron 113-117 fibrinogen beta chain Homo sapiens 3-13 14577148-7 2003 Ancystron-H is used for determination of fibrinogen level in blood plasma of patients undergoing heparin treatment and blood coagulation inhibitors accumulation. ancystron-h 0-11 fibrinogen beta chain Homo sapiens 41-51 12850842-7 2003 Fibrinogen binding and microaggregate formation were reduced by Roxifiban dosing in a dose-dependent manner. roxifiban 64-73 fibrinogen beta chain Homo sapiens 0-10 12702176-0 2003 Changes in functional activities of plasma fibrinogen after treatment with methylene blue and red light. Methylene Blue 75-89 fibrinogen beta chain Homo sapiens 43-53 12702176-1 2003 BACKGROUND: Methylene blue (MB) plus light treatment used for virus inactivation of human plasma units may lead to changes in the functional activities of fibrinogen. Methylene Blue 12-26 fibrinogen beta chain Homo sapiens 155-165 12702176-1 2003 BACKGROUND: Methylene blue (MB) plus light treatment used for virus inactivation of human plasma units may lead to changes in the functional activities of fibrinogen. Methylene Blue 28-30 fibrinogen beta chain Homo sapiens 155-165 14577148-7 2003 Ancystron-H is used for determination of fibrinogen level in blood plasma of patients undergoing heparin treatment and blood coagulation inhibitors accumulation. Heparin 97-104 fibrinogen beta chain Homo sapiens 41-51 12582160-0 2003 Decorin binds fibrinogen in a Zn2+-dependent interaction. Zinc 30-34 fibrinogen beta chain Homo sapiens 14-24 12582160-4 2003 We now report that the decorin proteoglycan binds fibrinogen in the presence of Zn(2+). Zinc 80-82 fibrinogen beta chain Homo sapiens 50-60 12732795-2 2003 Alcohol intake has important effects on risk factors for reinfarction, including higher levels of high-density lipoprotein cholesterol and triglycerides, lower levels of fibrinogen and other prothrombotic factors, lower fibrinolytic potential, and antiplatelet activity. Alcohols 0-7 fibrinogen beta chain Homo sapiens 170-180 12635002-8 2003 These results from controlled human exposure linked specific PM components to pulmonary neutrolphil influx and blood fibrinogen increase, and indicated the soluble components of pollutant particles may differentially affect pulmonary and hematological systems in humans exposed to PM. Promethium 61-63 fibrinogen beta chain Homo sapiens 117-127 12659599-13 2003 Moreover, fibrinogen levels decreased with simvastatin and atorvastatin, but these reductions were significant only for simvastatin (p < 0.05). Simvastatin 43-54 fibrinogen beta chain Homo sapiens 10-20 12659599-13 2003 Moreover, fibrinogen levels decreased with simvastatin and atorvastatin, but these reductions were significant only for simvastatin (p < 0.05). Atorvastatin 59-71 fibrinogen beta chain Homo sapiens 10-20 12695755-3 2003 DNA sequence analysis of the fibrinogen Aalpha, Bbeta and gamma-genes revealed a homozygous deletion of two adenines between nucleotides 3120 and 3122 in exon 4 of the gene coding for the Aalpha-chain. Adenine 108-116 fibrinogen beta chain Homo sapiens 29-39 12975594-1 2003 Orbofiban is a unique antiplatelet agent that inhibits the binding of fibrinogen to gycoprotein (GP) IIb/IIIa integrin receptors and thus prevents platelet aggregation induced by various agents. orbofiban 0-9 fibrinogen beta chain Homo sapiens 70-80 12617683-4 2003 While lysozyme molecules adsorbed on silica surfaces yield relatively similar SFG spectra, regardless of the surface concentration, SFG spectra of fibrinogen and BSA adsorbed on silica surfaces exhibit concentration-dependent signal intensities and peak shapes. Silicon Dioxide 178-184 fibrinogen beta chain Homo sapiens 147-157 12615272-0 2003 Effect of atorvastatin (80 mg) and simvastatin (40 mg) on plasma fibrinogen levels and on carotid intima media thickness in patients with familial hypercholesterolemia. Atorvastatin 10-22 fibrinogen beta chain Homo sapiens 65-75 12615272-0 2003 Effect of atorvastatin (80 mg) and simvastatin (40 mg) on plasma fibrinogen levels and on carotid intima media thickness in patients with familial hypercholesterolemia. Simvastatin 35-46 fibrinogen beta chain Homo sapiens 65-75 12761163-0 2003 N-acetylglucosamine-6-O-sulfotransferase-1: production in the baculovirus system and its applications to the synthesis of a sulfated oligosaccharide and to the modification of oligosaccharides in fibrinogen. Oligosaccharides 176-192 fibrinogen beta chain Homo sapiens 196-206 12771860-9 2003 In hypertensive patients with diabetes, fibrinogen was significantly higher (466+/-176 mg/dL, n=14) than in those hypertensive without diabetes (333+/-87 mg/dL, n=113, p=0.001) and in all patients there was a a significant correlation (r=0.474, p<0.001) between blood glucose and fibrinogen. Blood Glucose 265-278 fibrinogen beta chain Homo sapiens 40-50 12761163-7 2003 The purified recombinant enzyme was also used to sulfate oligosaccharide chains on fibrinogen after enzymatic desialylation and degalactosylation to expose nonreducing GlcNAc residues. sulfate oligosaccharide 49-72 fibrinogen beta chain Homo sapiens 83-93 12761163-7 2003 The purified recombinant enzyme was also used to sulfate oligosaccharide chains on fibrinogen after enzymatic desialylation and degalactosylation to expose nonreducing GlcNAc residues. 2-acetamido-2-deoxy-4-O-(beta-2-acetamid-2-deoxyglucopyranosyl)glucopyranose 168-174 fibrinogen beta chain Homo sapiens 83-93 12573244-0 2003 Familial hypofibrinogenaemia associated with heterozygous substitution of a conserved arginine residue; Bbeta255 Arg-->His (Fibrinogen Merivale). Arginine 86-94 fibrinogen beta chain Homo sapiens 124-134 12603495-9 2003 The relative risk for death of all causes increased 1.43 (95% CI, 1.08-1.88) per tHcy quartile (P for trend = 0.01), and was only modestly reduced after adjustment for age, ejection fraction, total cholesterol, C-reactive protein, fibrinogen, smoking and hypertension to 1.37 (95% CI, 1.04-1.80) (P for trend = 0.03). thcy 81-85 fibrinogen beta chain Homo sapiens 231-241 12573244-0 2003 Familial hypofibrinogenaemia associated with heterozygous substitution of a conserved arginine residue; Bbeta255 Arg-->His (Fibrinogen Merivale). bbeta255 104-112 fibrinogen beta chain Homo sapiens 124-134 12573244-0 2003 Familial hypofibrinogenaemia associated with heterozygous substitution of a conserved arginine residue; Bbeta255 Arg-->His (Fibrinogen Merivale). Arginine 113-116 fibrinogen beta chain Homo sapiens 124-134 12573244-0 2003 Familial hypofibrinogenaemia associated with heterozygous substitution of a conserved arginine residue; Bbeta255 Arg-->His (Fibrinogen Merivale). Histidine 119-122 fibrinogen beta chain Homo sapiens 124-134 12573244-2 2003 Family studies showed the mutations Bbeta255 Arg-->His (Fibrinogen Merivale) and Bbeta148 Lys-->Asn (Fibrinogen Merivale II) were on different alleles and that only the Bbeta255 Arg-->His mutation segregated with hypofibrinogenaemia. Arginine 45-48 fibrinogen beta chain Homo sapiens 56-66 12573244-2 2003 Family studies showed the mutations Bbeta255 Arg-->His (Fibrinogen Merivale) and Bbeta148 Lys-->Asn (Fibrinogen Merivale II) were on different alleles and that only the Bbeta255 Arg-->His mutation segregated with hypofibrinogenaemia. Histidine 51-54 fibrinogen beta chain Homo sapiens 56-66 12573244-2 2003 Family studies showed the mutations Bbeta255 Arg-->His (Fibrinogen Merivale) and Bbeta148 Lys-->Asn (Fibrinogen Merivale II) were on different alleles and that only the Bbeta255 Arg-->His mutation segregated with hypofibrinogenaemia. Lysine 90-93 fibrinogen beta chain Homo sapiens 101-111 12573244-2 2003 Family studies showed the mutations Bbeta255 Arg-->His (Fibrinogen Merivale) and Bbeta148 Lys-->Asn (Fibrinogen Merivale II) were on different alleles and that only the Bbeta255 Arg-->His mutation segregated with hypofibrinogenaemia. Asparagine 96-99 fibrinogen beta chain Homo sapiens 101-111 12573244-8 2003 Both the Arg and Gly are absolutely conserved, not only in all known Bbeta chains, but also in all homologous alphaE and gamma chains and in all fibrinogen-related proteins. Arginine 9-12 fibrinogen beta chain Homo sapiens 145-155 12573244-8 2003 Both the Arg and Gly are absolutely conserved, not only in all known Bbeta chains, but also in all homologous alphaE and gamma chains and in all fibrinogen-related proteins. Glycine 17-20 fibrinogen beta chain Homo sapiens 145-155 12581266-8 2003 After controlling for age, both PAI-1 and tPA-PAI-1 showed significant negative correlations with HDL-cholesterol, and positive correlations with triglycerides, WHR, HbA1 and fibrinogen. Tetradecanoylphorbol Acetate 42-45 fibrinogen beta chain Homo sapiens 175-185 12598072-10 2003 The addition of sialic acid, which inhibits RBC-RBC aggregation, decreased the amount of SEC, even in the presence of Fg. N-Acetylneuraminic Acid 16-27 fibrinogen beta chain Homo sapiens 118-120 12871500-4 2003 Ioxaglate inhibits the clotting of fibrinogen and the activation of factors V and VIII, and of platelets by thrombin. Ioxaglic Acid 0-9 fibrinogen beta chain Homo sapiens 35-45 12646373-4 2003 In addition, trimethylamine oxide (TMAO) was found to improve the diffraction of fibrinogen crystals. trimethyloxamine 13-33 fibrinogen beta chain Homo sapiens 81-91 12574816-0 2003 Effect of fibrinogen concentration and platelet count on the inhibitory effect of abciximab and tirofiban. Tirofiban 96-105 fibrinogen beta chain Homo sapiens 10-20 12574816-3 2003 High fibrinogen concentrations reduced platelet inhibition by tirofiban, assessed in whole blood (r = -0.85, n = 10, p <0.01) and in platelet rich plasma (r = -0.89, n = 10, p <0.01) through PFA 100 and Born"s aggregometry assay, respectively. Tirofiban 62-71 fibrinogen beta chain Homo sapiens 5-15 12574816-3 2003 High fibrinogen concentrations reduced platelet inhibition by tirofiban, assessed in whole blood (r = -0.85, n = 10, p <0.01) and in platelet rich plasma (r = -0.89, n = 10, p <0.01) through PFA 100 and Born"s aggregometry assay, respectively. Foscarnet 197-200 fibrinogen beta chain Homo sapiens 5-15 12630114-1 2003 The influence of oxidized fibrinogen on the intensity of luminol-dependent chemilumin escence of blood leukocytes, stimulated by opsonized zymosan was studied. Luminol 57-64 fibrinogen beta chain Homo sapiens 26-36 12630114-1 2003 The influence of oxidized fibrinogen on the intensity of luminol-dependent chemilumin escence of blood leukocytes, stimulated by opsonized zymosan was studied. Zymosan 139-146 fibrinogen beta chain Homo sapiens 26-36 12630114-2 2003 It was shown that the introduction of fibrinogen modified by UV-irradiation in to a suspension of cells resulted in a significant increase in the intensity of the luminol-dependent chemiluminescence of leukocytes. Luminol 163-170 fibrinogen beta chain Homo sapiens 38-48 12717506-3 2003 The increase in fibrinogen content was associated with high levels of total lipids and triglycerides and low concentration of high-density lipoprotein cholesterol. Triglycerides 87-100 fibrinogen beta chain Homo sapiens 16-26 12698015-2 2003 Clopidogrel and ticlopidine are adenosine diphosphate (ADP)-receptor antagonists that inhibit ADP-induced fibrinogen binding to platelets, a necessary step in the platelet aggregation process. Clopidogrel 0-11 fibrinogen beta chain Homo sapiens 106-116 12698015-2 2003 Clopidogrel and ticlopidine are adenosine diphosphate (ADP)-receptor antagonists that inhibit ADP-induced fibrinogen binding to platelets, a necessary step in the platelet aggregation process. Ticlopidine 16-27 fibrinogen beta chain Homo sapiens 106-116 12698015-2 2003 Clopidogrel and ticlopidine are adenosine diphosphate (ADP)-receptor antagonists that inhibit ADP-induced fibrinogen binding to platelets, a necessary step in the platelet aggregation process. Adenosine Diphosphate 55-58 fibrinogen beta chain Homo sapiens 106-116 12598849-11 2003 RESULTS: The patients who received tamoxifen with or without estrogen replacement therapy showed after 24 months, a reduction of T-C, LDL-C and FBR (p<0.01); the HDL-C levels did not vary significantly compared to the control group (p=NS); the 26 patients of group A showed an increase of HDL-C (p<0.02). Tamoxifen 35-44 fibrinogen beta chain Homo sapiens 144-147 13130176-10 2003 Fibrinogen also correlated positively with age, BMI, arterial systolic pressure, cholesterol, cholesterol-LDL, smoking, CRP and vWF (p < 0.01). Cholesterol 81-92 fibrinogen beta chain Homo sapiens 0-10 13130176-10 2003 Fibrinogen also correlated positively with age, BMI, arterial systolic pressure, cholesterol, cholesterol-LDL, smoking, CRP and vWF (p < 0.01). Cholesterol 94-105 fibrinogen beta chain Homo sapiens 0-10 12755140-5 2003 A one-unit difference in low density lipoprotein (LDL)/high density lipoprotein cholesterol (HDL) cholesterol ratio was associated with a 17% higher risk (hazard ratio = 1.17, p < 0.05); hypertension increased the risk for an adverse event (hazard ratio = 3.02, p < 0.05) and a 1 mg/dl increase in plasma fibrinogen level was associated with a 4% higher CHD risk (hazard ratio = 1.04, p < 0.05). Cholesterol 80-91 fibrinogen beta chain Homo sapiens 311-321 12646373-4 2003 In addition, trimethylamine oxide (TMAO) was found to improve the diffraction of fibrinogen crystals. trimethyloxamine 35-39 fibrinogen beta chain Homo sapiens 81-91 12493021-3 2003 Type I is an hereditary hypofibrinogenaemia genetically characterized by a mutant variant of the fibrinogen molecule designated as fibrinogen Brescia, consistent with a gamma284 Gly-->Arg mutation. gamma284 gly 169-181 fibrinogen beta chain Homo sapiens 97-107 12493021-3 2003 Type I is an hereditary hypofibrinogenaemia genetically characterized by a mutant variant of the fibrinogen molecule designated as fibrinogen Brescia, consistent with a gamma284 Gly-->Arg mutation. Arginine 187-190 fibrinogen beta chain Homo sapiens 97-107 15106288-5 2003 In the acute phase of their disease, the patients with APV exhibited increased plasma levels of fibrinogen (341.5 +/- 136.8 standard deviation [SD] versus 268.1 +/- 72.6 SD mg/dl; p = .05); increased plasma levels of D-dimer (305 +/- 158 SD versus 201 +/- 106 SD ng/dl; p = .008); enhanced plasma levels of lipoprotein (a) (42.6 +/- 38.5 SD versus 16.9 +/- 17.7 SD mg/dl; F = 5.67, p = .02); high leukocyte count (9.2 +/- 2.7 SD versus 6.4 +/- 1.2 SD x 10(3)/microliter; F = 8.42, p < .006); and low serum folate concentration (5.1 +/- 1.7 SD versus 7.2 +/- 2.6 SD ng/ml; F = 4.34, p = .04). Folic Acid 509-515 fibrinogen beta chain Homo sapiens 96-106 12661663-1 2003 The paper investigates the conformational stability of bovine serum albumin (BSA) and fibrinogen during 24-h incubation in turn with a linear silicone polymer (polydimethylsiloxane (PDMS)), with linear silicone oligomers (hexamethyldisiloxane and octamethyltrisiloxane) and with cyclic silicone oligomers (octamethylcyclotetrasiloxane (D4) and decamethylcyclopentasiloxane (D5)). Silicones 142-150 fibrinogen beta chain Homo sapiens 86-96 16256461-0 2003 Induced removal of dipalmitoyl phosphatidylcholine by the exclusion of fibrinogen from compressed monolayers at air/liquid interfaces. 1,2-Dipalmitoylphosphatidylcholine 19-50 fibrinogen beta chain Homo sapiens 71-81 18924618-4 2003 With a new procedure getting high purified fibrinogen by glycine precipitation, the calibrator determined by both the Clauss and Jacobson methods produced a fibrinogen concentration of 2.20 g l(-1). Glycine 57-64 fibrinogen beta chain Homo sapiens 43-53 18924618-4 2003 With a new procedure getting high purified fibrinogen by glycine precipitation, the calibrator determined by both the Clauss and Jacobson methods produced a fibrinogen concentration of 2.20 g l(-1). Glycine 57-64 fibrinogen beta chain Homo sapiens 157-167 18924717-6 2003 Purified fibrinogen was prepared using Cohn fraction 1 and glycine precipitation. Glycine 59-66 fibrinogen beta chain Homo sapiens 9-19 16256461-1 2003 The induced removal of dipalmitoyl phosphatidylcholine (DPPC) by the exclusion of fibrinogen from mixed DPPC/fibrinogen monolayers at compressed air/liquid interfaces was analyzed. 1,2-Dipalmitoylphosphatidylcholine 23-54 fibrinogen beta chain Homo sapiens 82-92 16256461-1 2003 The induced removal of dipalmitoyl phosphatidylcholine (DPPC) by the exclusion of fibrinogen from mixed DPPC/fibrinogen monolayers at compressed air/liquid interfaces was analyzed. 1,2-Dipalmitoylphosphatidylcholine 56-60 fibrinogen beta chain Homo sapiens 82-92 16256461-1 2003 The induced removal of dipalmitoyl phosphatidylcholine (DPPC) by the exclusion of fibrinogen from mixed DPPC/fibrinogen monolayers at compressed air/liquid interfaces was analyzed. 1,2-Dipalmitoylphosphatidylcholine 56-60 fibrinogen beta chain Homo sapiens 109-119 16256461-4 2003 For mixed monolayers of DPPC with fibrinogen, the fibrinogen molecules were expelled from the interface upon compression due to the presence of insoluble DPPC molecules. 1,2-Dipalmitoylphosphatidylcholine 24-28 fibrinogen beta chain Homo sapiens 34-44 16256461-4 2003 For mixed monolayers of DPPC with fibrinogen, the fibrinogen molecules were expelled from the interface upon compression due to the presence of insoluble DPPC molecules. 1,2-Dipalmitoylphosphatidylcholine 24-28 fibrinogen beta chain Homo sapiens 50-60 16256461-4 2003 For mixed monolayers of DPPC with fibrinogen, the fibrinogen molecules were expelled from the interface upon compression due to the presence of insoluble DPPC molecules. 1,2-Dipalmitoylphosphatidylcholine 154-158 fibrinogen beta chain Homo sapiens 34-44 16256461-4 2003 For mixed monolayers of DPPC with fibrinogen, the fibrinogen molecules were expelled from the interface upon compression due to the presence of insoluble DPPC molecules. 1,2-Dipalmitoylphosphatidylcholine 154-158 fibrinogen beta chain Homo sapiens 50-60 16256461-5 2003 The squeeze-out of fibrinogen molecules evidently removed a significant number of DPPC molecules from the interface, with the extent depending on fibrinogen surface concentration. 1,2-Dipalmitoylphosphatidylcholine 82-86 fibrinogen beta chain Homo sapiens 19-29 16256461-5 2003 The squeeze-out of fibrinogen molecules evidently removed a significant number of DPPC molecules from the interface, with the extent depending on fibrinogen surface concentration. 1,2-Dipalmitoylphosphatidylcholine 82-86 fibrinogen beta chain Homo sapiens 146-156 16256461-7 2003 The induced loss of free DPPC molecules at the interface by the expelled fibrinogen molecules during the area compression stage was then evaluated from the hysteresis curves. 1,2-Dipalmitoylphosphatidylcholine 25-29 fibrinogen beta chain Homo sapiens 73-83 12524616-6 2003 MATERIALS AND METHODS: Physiological clot formation of fibrinogen by thrombin and free-radical-induced crosslinking of fibrinogen and of fibronectin were analyzed using spectrophotometric turbidity measurements, light-scattering techniques, polyacrylamide gel electrophoresis (PAGE), and rotary shadowing. polyacrylamide 241-255 fibrinogen beta chain Homo sapiens 55-65 14593356-9 2003 Compared with their controls ticlopidine treated patients in 7 days after ticlopidine discontinuation had lower levels of TAT (2.77 and 3.61 ng/ml, r<0.05) and fibrinogen (3.16 and 3.84 g/l, r<0.05). Ticlopidine 29-40 fibrinogen beta chain Homo sapiens 163-173 14593356-9 2003 Compared with their controls ticlopidine treated patients in 7 days after ticlopidine discontinuation had lower levels of TAT (2.77 and 3.61 ng/ml, r<0.05) and fibrinogen (3.16 and 3.84 g/l, r<0.05). Ticlopidine 74-85 fibrinogen beta chain Homo sapiens 163-173 14593356-13 2003 CONCLUSION: Short term use of ticlopidine in patients with NSTEACS treated with aspirin and unfractionated heparin was associated with lower levels of TAT and fibrinogen (relative to control group) on day 14. Ticlopidine 30-41 fibrinogen beta chain Homo sapiens 159-169 14593356-13 2003 CONCLUSION: Short term use of ticlopidine in patients with NSTEACS treated with aspirin and unfractionated heparin was associated with lower levels of TAT and fibrinogen (relative to control group) on day 14. Aspirin 80-87 fibrinogen beta chain Homo sapiens 159-169 14593356-13 2003 CONCLUSION: Short term use of ticlopidine in patients with NSTEACS treated with aspirin and unfractionated heparin was associated with lower levels of TAT and fibrinogen (relative to control group) on day 14. Heparin 107-114 fibrinogen beta chain Homo sapiens 159-169 15526497-6 2003 Mean values of fibrinogen are significantly more elevated in PP > 50 mmHg group than in PP < 50 mmHg group (364.79 +/- 71.07 vs. 329.31 +/- 57.81, P < 0.05). pp < 91-97 fibrinogen beta chain Homo sapiens 15-25 14594322-8 2003 Establishment of fibrinogen, prothrombin fragment 1 + 2 and thrombus precursor protein plasma concentrations yielded enhanced results for PMMA compared with the results for treatment with F-60 dialysis membranes. Polymethyl Methacrylate 138-142 fibrinogen beta chain Homo sapiens 17-27 12679130-1 2003 Triflavin, an Arg-Gly-Asp (RGD)-containing disintegrin purified from venom peptide inhibited platelet aggregation by interfering with the interaction of fibrinogen with alpha(IIb)beta(3) integrin. triflavin 0-9 fibrinogen beta chain Homo sapiens 153-163 12679130-1 2003 Triflavin, an Arg-Gly-Asp (RGD)-containing disintegrin purified from venom peptide inhibited platelet aggregation by interfering with the interaction of fibrinogen with alpha(IIb)beta(3) integrin. arginyl-glycyl-aspartic acid 14-25 fibrinogen beta chain Homo sapiens 153-163 14678811-7 2003 The percentage high molecular weight fibrinogen was assessed by SDS-electrophoresis and densitometry after isolation of fibrinogen by precipitation. Sodium Dodecyl Sulfate 64-67 fibrinogen beta chain Homo sapiens 37-47 14987914-10 2003 At 3 and 6 months, 78% of the variance of fibrinogen could be explained by the influence of TSA. trichostatin A 92-95 fibrinogen beta chain Homo sapiens 42-52 14989564-8 2003 All agents that lower fibrinogen also have other cardiovascular effects such as a decrease in cholesterol or inflammation. Cholesterol 94-105 fibrinogen beta chain Homo sapiens 22-32 12666442-4 2002 The aim of this study was to evaluate the effect of fenofibrate on the plasma levels of Plasminogen Activator Inhibitor type 1 (PAI-1) and fibrinogen in patients with combined dyslipidemia. Fenofibrate 52-63 fibrinogen beta chain Homo sapiens 139-149 12561343-1 2002 In this paper, the adsorption of human serum albumin(HSA), human serum fibrinogen (HFG) and human serum immunoglobin(IgG) on diamond like carbon film(DLC) has been studied in comparison with diamond film (DF) and graphite. Carbon 138-144 fibrinogen beta chain Homo sapiens 71-81 12410365-7 2002 The relationship between low levels of fibrinogen and factor VII antigen was diminished adjusting for the sex steroids. Steroids 110-118 fibrinogen beta chain Homo sapiens 39-49 12393098-7 2002 Fibrinogen level was significantly correlated with body mass index, systolic blood pressure, plasma triglycerides, fasting plasma glucose, HbA1c, PAI(active), tPA and von Willebrandt factor, as well as with smoking and low physical activity. Triglycerides 100-113 fibrinogen beta chain Homo sapiens 0-10 12393098-7 2002 Fibrinogen level was significantly correlated with body mass index, systolic blood pressure, plasma triglycerides, fasting plasma glucose, HbA1c, PAI(active), tPA and von Willebrandt factor, as well as with smoking and low physical activity. Glucose 130-137 fibrinogen beta chain Homo sapiens 0-10 12661663-5 2003 In contrast, the tertiary structure of fibrinogen was found to be altered by both short-chain linear siloxanes: (hexamethyldisiloxane and octamethyltrisiloxane) and long-chain PDMS. Siloxanes 101-110 fibrinogen beta chain Homo sapiens 39-49 12661663-5 2003 In contrast, the tertiary structure of fibrinogen was found to be altered by both short-chain linear siloxanes: (hexamethyldisiloxane and octamethyltrisiloxane) and long-chain PDMS. hexamethyldisiloxane 113-133 fibrinogen beta chain Homo sapiens 39-49 12661663-5 2003 In contrast, the tertiary structure of fibrinogen was found to be altered by both short-chain linear siloxanes: (hexamethyldisiloxane and octamethyltrisiloxane) and long-chain PDMS. Simethicone 138-159 fibrinogen beta chain Homo sapiens 39-49 14663596-2 2003 By means of heparin and lowering the pH level, lipoproteins and fibrinogen are reduced by 50-60%. Heparin 12-19 fibrinogen beta chain Homo sapiens 64-74 14663601-8 2003 In a prospective pilot-study we examined whether drastic postoperative lowering of fibrinogen by H.E.L.P.-(Heparin-mediated Extracorporeal LDL-/Fibrinogen Precipitation) apheresis can prevent early graft vessel closure in patients undergoing CABG. Heparin 107-114 fibrinogen beta chain Homo sapiens 83-93 14663601-8 2003 In a prospective pilot-study we examined whether drastic postoperative lowering of fibrinogen by H.E.L.P.-(Heparin-mediated Extracorporeal LDL-/Fibrinogen Precipitation) apheresis can prevent early graft vessel closure in patients undergoing CABG. Heparin 107-114 fibrinogen beta chain Homo sapiens 144-154 12377763-5 2002 Grafting the alpha(M)(Lys(245)-Arg(261)) sequence converted alpha(L)beta(2) into a fibrinogen-binding protein capable of mediating efficient and specific adhesion similar to that of wild-type alpha(M)beta(2). Lysine 22-25 fibrinogen beta chain Homo sapiens 83-93 12377763-5 2002 Grafting the alpha(M)(Lys(245)-Arg(261)) sequence converted alpha(L)beta(2) into a fibrinogen-binding protein capable of mediating efficient and specific adhesion similar to that of wild-type alpha(M)beta(2). Arginine 31-34 fibrinogen beta chain Homo sapiens 83-93 12480357-12 2002 INTERPRETATION: A single fibrinogen/LDL apheresis lasting for 2 h could be used as an alternative to conventional infusion treatment and prednisolone for 10 days. Prednisolone 137-149 fibrinogen beta chain Homo sapiens 25-35 12441907-2 2002 To elucidate the mechanism of the relation of serum sialic acid to fibrinogen, the relationship between serum sialic acid and markers of blood coagulation activity was investigated in type 2 diabetic patients. N-Acetylneuraminic Acid 52-63 fibrinogen beta chain Homo sapiens 67-77 12441907-3 2002 The concentration of serum sialic acid showed significant positive correlations with blood platelet count and with plasma concentrations of fibrinogen, D-dimer, thrombin-antithrombin III complex and plasmin-alpha2 plasmin inhibitor complex. N-Acetylneuraminic Acid 27-38 fibrinogen beta chain Homo sapiens 140-150 12441907-5 2002 The correlation coefficient of blood fibrinogen with serum sialic acid was still significant after adjustment for D-dimer, thrombin-antithrombin III complex or plasmin-alpha2 plasmin inhibitor complex. N-Acetylneuraminic Acid 59-70 fibrinogen beta chain Homo sapiens 37-47 12441907-7 2002 These results suggest that the serum sialic acid level reflects blood coagulation activity in type 2 diabetic patients and is related to blood fibrinogen level independently of blood coagulation activity. N-Acetylneuraminic Acid 37-48 fibrinogen beta chain Homo sapiens 143-153 12472585-9 2002 (1) Magnesium sulphate may initially induce membrane fluidity changes with resulting interference of fibrinogen binding to the GPIIb/IIIa complex, followed by inhibition of phosphoinositide breakdown and thromboxane A2 formation, thereby leading to inhibition of both intracellular Ca2+ mobilization and phosphorylation of P47. Magnesium Sulfate 4-22 fibrinogen beta chain Homo sapiens 101-111 12445532-3 2002 This study confirmed the well-documented bivariate relationship between plasma fibrinogen levels and gender, age, educational level, smoking, obesity, physical activity, alcohol consumption, total cholesterol, HDL-cholesterol, arterial hypertension and diabetes. Alcohols 170-177 fibrinogen beta chain Homo sapiens 79-89 12445532-3 2002 This study confirmed the well-documented bivariate relationship between plasma fibrinogen levels and gender, age, educational level, smoking, obesity, physical activity, alcohol consumption, total cholesterol, HDL-cholesterol, arterial hypertension and diabetes. Cholesterol 197-208 fibrinogen beta chain Homo sapiens 79-89 12445532-3 2002 This study confirmed the well-documented bivariate relationship between plasma fibrinogen levels and gender, age, educational level, smoking, obesity, physical activity, alcohol consumption, total cholesterol, HDL-cholesterol, arterial hypertension and diabetes. Cholesterol 214-225 fibrinogen beta chain Homo sapiens 79-89 12486406-2 2002 In in vitro studies, we combined ethanol with LY309562, a novel 2,6-disubstituted isoquinolone RGD mimic that competes for fibrinogen binding to GPIIb/IIIa. Ethanol 33-40 fibrinogen beta chain Homo sapiens 123-133 12486406-2 2002 In in vitro studies, we combined ethanol with LY309562, a novel 2,6-disubstituted isoquinolone RGD mimic that competes for fibrinogen binding to GPIIb/IIIa. LY309562 46-54 fibrinogen beta chain Homo sapiens 123-133 12486406-2 2002 In in vitro studies, we combined ethanol with LY309562, a novel 2,6-disubstituted isoquinolone RGD mimic that competes for fibrinogen binding to GPIIb/IIIa. 2,6-disubstituted isoquinolone 64-94 fibrinogen beta chain Homo sapiens 123-133 15348671-7 2002 Studies of EC morphology showed the predominant peripheral organization of actin filaments and the formation of distinct leading and trailing cell edges suggesting a motile phenotype of cells when they are seeded on FNG. ec 11-13 fibrinogen beta chain Homo sapiens 216-219 12324470-7 2002 Among these sequences, Gln(199)-Ala(203), Leu(225)-Leu(230), and Gly(305)-His(309) are important for the binding of both ligands, whereas Arg(144)-Lys(148) is more critical for fibrinogen than for C3bi binding. Glutamine 23-26 fibrinogen beta chain Homo sapiens 177-187 12324470-7 2002 Among these sequences, Gln(199)-Ala(203), Leu(225)-Leu(230), and Gly(305)-His(309) are important for the binding of both ligands, whereas Arg(144)-Lys(148) is more critical for fibrinogen than for C3bi binding. Alanine 32-35 fibrinogen beta chain Homo sapiens 177-187 12324470-7 2002 Among these sequences, Gln(199)-Ala(203), Leu(225)-Leu(230), and Gly(305)-His(309) are important for the binding of both ligands, whereas Arg(144)-Lys(148) is more critical for fibrinogen than for C3bi binding. Leucine 42-45 fibrinogen beta chain Homo sapiens 177-187 12324470-7 2002 Among these sequences, Gln(199)-Ala(203), Leu(225)-Leu(230), and Gly(305)-His(309) are important for the binding of both ligands, whereas Arg(144)-Lys(148) is more critical for fibrinogen than for C3bi binding. Leucine 51-54 fibrinogen beta chain Homo sapiens 177-187 12324470-7 2002 Among these sequences, Gln(199)-Ala(203), Leu(225)-Leu(230), and Gly(305)-His(309) are important for the binding of both ligands, whereas Arg(144)-Lys(148) is more critical for fibrinogen than for C3bi binding. Glycine 65-68 fibrinogen beta chain Homo sapiens 177-187 12324470-7 2002 Among these sequences, Gln(199)-Ala(203), Leu(225)-Leu(230), and Gly(305)-His(309) are important for the binding of both ligands, whereas Arg(144)-Lys(148) is more critical for fibrinogen than for C3bi binding. Histidine 74-77 fibrinogen beta chain Homo sapiens 177-187 12324470-7 2002 Among these sequences, Gln(199)-Ala(203), Leu(225)-Leu(230), and Gly(305)-His(309) are important for the binding of both ligands, whereas Arg(144)-Lys(148) is more critical for fibrinogen than for C3bi binding. Arginine 138-141 fibrinogen beta chain Homo sapiens 177-187 12324470-7 2002 Among these sequences, Gln(199)-Ala(203), Leu(225)-Leu(230), and Gly(305)-His(309) are important for the binding of both ligands, whereas Arg(144)-Lys(148) is more critical for fibrinogen than for C3bi binding. Lysine 147-150 fibrinogen beta chain Homo sapiens 177-187 12428106-3 2002 Blockade of fibrinogen binding to platelets by Lamifiban, a competitive antagonist of GPIIb-IIIa (integrin alpha(IIb)beta(3)), reversed this inhibition, leading to a marked increase in integrin alpha(2)beta(1)-dependent platelet adhesion. lamifiban 47-56 fibrinogen beta chain Homo sapiens 12-22 12428180-0 2002 Moderate alcohol consumption reduces plasma C-reactive protein and fibrinogen levels; a randomized, diet-controlled intervention study. Alcohols 9-16 fibrinogen beta chain Homo sapiens 67-77 12428180-1 2002 OBJECTIVE: To evaluate the effect of moderate alcohol consumption on the acute phase proteins C-reactive protein and fibrinogen. Alcohols 46-53 fibrinogen beta chain Homo sapiens 117-127 12428180-11 2002 CONCLUSIONS: Moderate alcohol consumption significantly decreased plasma C-reactive protein and fibrinogen levels. Alcohols 22-29 fibrinogen beta chain Homo sapiens 96-106 12209946-0 2002 Interaction of fibrinogen with surfaces of end-group-modified polyurethanes: a surface-specific sum-frequency-generation vibrational spectroscopy study. Polyurethanes 62-75 fibrinogen beta chain Homo sapiens 15-25 12209946-1 2002 Fibrinogen adsorption on polyurethanes with different surface-modifying end groups (SMEs) has been studied with sum-frequency-generation vibrational spectroscopy (SFG). Polyurethanes 25-38 fibrinogen beta chain Homo sapiens 0-10 12209946-3 2002 Fibrinogen binds weakly on the hydrophilic backbone of a poly(dimethyl siloxane) (PDMS)-modified polyurethane surface but leaves the hydrophobic PDMS part untouched. baysilon 57-80 fibrinogen beta chain Homo sapiens 0-10 12209946-3 2002 Fibrinogen binds weakly on the hydrophilic backbone of a poly(dimethyl siloxane) (PDMS)-modified polyurethane surface but leaves the hydrophobic PDMS part untouched. Polyurethanes 97-109 fibrinogen beta chain Homo sapiens 0-10 12209946-4 2002 On sulfonate end-group-modified (SO(3(-) )) polyurethane surfaces, fibrinogen adsorbs well. sulfonate 3-12 fibrinogen beta chain Homo sapiens 67-77 12209946-4 2002 On sulfonate end-group-modified (SO(3(-) )) polyurethane surfaces, fibrinogen adsorbs well. Polyurethanes 44-56 fibrinogen beta chain Homo sapiens 67-77 12428106-4 2002 Analysis of integrin alpha(2)beta(1)-dependent platelet adhesion to collagen indicated that ADP-induced suppression of platelet adhesion is the result of trans-dominant inhibition of integrin alpha(2)beta(1) caused by fibrinogen binding to integrin GPIIb-IIIa. Adenosine Diphosphate 92-95 fibrinogen beta chain Homo sapiens 218-228 12428106-5 2002 Lamifiban blocked fibrinogen binding, reversing the trans-dominant inhibition of alpha(2)beta(1) dependent adhesion to collagen. lamifiban 0-9 fibrinogen beta chain Homo sapiens 18-28 12356313-0 2002 2.8 A crystal structures of recombinant fibrinogen fragment D with and without two peptide ligands: GHRP binding to the "b" site disrupts its nearby calcium-binding site. Calcium 149-156 fibrinogen beta chain Homo sapiens 40-50 12385861-8 2002 The decreased levels of fibrinogen and factor VIIc found during treatment with 17beta-oestradiol/norethisterone acetate or tibolone may offer some degree of cardioprotection in healthy woman without pre-existing disease. Estradiol 79-96 fibrinogen beta chain Homo sapiens 24-34 12385861-8 2002 The decreased levels of fibrinogen and factor VIIc found during treatment with 17beta-oestradiol/norethisterone acetate or tibolone may offer some degree of cardioprotection in healthy woman without pre-existing disease. Norethindrone Acetate 97-119 fibrinogen beta chain Homo sapiens 24-34 12385861-8 2002 The decreased levels of fibrinogen and factor VIIc found during treatment with 17beta-oestradiol/norethisterone acetate or tibolone may offer some degree of cardioprotection in healthy woman without pre-existing disease. tibolone 123-131 fibrinogen beta chain Homo sapiens 24-34 12351391-0 2002 Thrombospondin and fibrinogen bind serotonin-derivatized proteins on COAT-platelets. Serotonin 35-44 fibrinogen beta chain Homo sapiens 19-29 12351391-4 2002 We now demonstrate that both thrombospondin and fibrinogen provide the requisite serotonin binding sites. Serotonin 81-90 fibrinogen beta chain Homo sapiens 48-58 12356313-4 2002 The structures reveal that recombinant fibrinogen is nearly identical to the plasma protein but with minor changes, like the addition of a proximal fucose to the carbohydrate linked to residue betaGln364, and slightly different relative positions of the beta- and gamma-modules. Fucose 148-154 fibrinogen beta chain Homo sapiens 39-49 12356313-4 2002 The structures reveal that recombinant fibrinogen is nearly identical to the plasma protein but with minor changes, like the addition of a proximal fucose to the carbohydrate linked to residue betaGln364, and slightly different relative positions of the beta- and gamma-modules. Carbohydrates 162-174 fibrinogen beta chain Homo sapiens 39-49 12356313-4 2002 The structures reveal that recombinant fibrinogen is nearly identical to the plasma protein but with minor changes, like the addition of a proximal fucose to the carbohydrate linked to residue betaGln364, and slightly different relative positions of the beta- and gamma-modules. betagln364 193-203 fibrinogen beta chain Homo sapiens 39-49 12356313-5 2002 Of major interest in our structures is that a previously identified calcium site in plasma fibrinogen is absent when Gly-His-Arg-Pro-amide is bound. Calcium 68-75 fibrinogen beta chain Homo sapiens 91-101 12356313-5 2002 Of major interest in our structures is that a previously identified calcium site in plasma fibrinogen is absent when Gly-His-Arg-Pro-amide is bound. gly-his-arg-pro-amide 117-138 fibrinogen beta chain Homo sapiens 91-101 12516687-9 2002 The patient was given low-molecular-weight heparin with a dramatic reduction in previously elevated fibrinogen level and a good control of the hepatic function. Heparin 43-50 fibrinogen beta chain Homo sapiens 100-110 12354170-6 2002 Also the tyrosine-kinase inhibitor herbimycin inhibited fibrinogen mediated secretion of chemokines. herbimycin 35-45 fibrinogen beta chain Homo sapiens 56-66 12368161-10 2002 Plasma TpP levels correlated significantly with other DIC parameters including platelet count, fibrinogen, antithrombin and TAT, and correlated weakly with D-dimer. tpp 7-10 fibrinogen beta chain Homo sapiens 95-105 12428424-6 2002 Using the optic method of the surface plasmon resonance they investigated the initial stage of interaction between fibrinogen and oxidized cellulose. Cellulose 139-148 fibrinogen beta chain Homo sapiens 115-125 12428424-7 2002 Oxidized cellulose retards and reduces the interaction of the immobilized fibrin monomer with fibrinogen. Cellulose 9-18 fibrinogen beta chain Homo sapiens 94-104 12198657-0 2002 Novel fibrinogen gamma375 Arg-->Trp mutation (fibrinogen aguadilla) causes hepatic endoplasmic reticulum storage and hypofibrinogenemia. Arginine 26-29 fibrinogen beta chain Homo sapiens 6-16 12198657-0 2002 Novel fibrinogen gamma375 Arg-->Trp mutation (fibrinogen aguadilla) causes hepatic endoplasmic reticulum storage and hypofibrinogenemia. Arginine 26-29 fibrinogen beta chain Homo sapiens 46-56 12198657-0 2002 Novel fibrinogen gamma375 Arg-->Trp mutation (fibrinogen aguadilla) causes hepatic endoplasmic reticulum storage and hypofibrinogenemia. Tryptophan 32-35 fibrinogen beta chain Homo sapiens 6-16 12198657-0 2002 Novel fibrinogen gamma375 Arg-->Trp mutation (fibrinogen aguadilla) causes hepatic endoplasmic reticulum storage and hypofibrinogenemia. Tryptophan 32-35 fibrinogen beta chain Homo sapiens 46-56 12431480-8 2002 Pretreatment of platelets with resveratrol (25-100 microg/ml, 30 min, 37 degrees C) had also inhibitory effects on adhesion of platelets to fibrinogen after stimulation of these cells by LPS alone or by LPS with thrombin at the same concentration. Resveratrol 31-42 fibrinogen beta chain Homo sapiens 140-150 12162736-0 2002 Crystal structure of fragment D from lamprey fibrinogen complexed with the peptide Gly-His-Arg-Pro-amide. glycylhistidine 83-90 fibrinogen beta chain Homo sapiens 45-55 12162736-0 2002 Crystal structure of fragment D from lamprey fibrinogen complexed with the peptide Gly-His-Arg-Pro-amide. arg-pro-amide 91-104 fibrinogen beta chain Homo sapiens 45-55 12149106-4 2002 Ramipril reduced resting TAT, and tended to reduce fibrinogen; Factor VII remained unchanged. Ramipril 0-8 fibrinogen beta chain Homo sapiens 51-61 12430881-1 2002 Fibrinogen is a 340-kDa plasma protein that is composed of two identical molecular halves, each consisting of three non-identical subunit polypeptides designated as A alpha, B beta- and gamma-chains held together by multiple disulfide bonds. Disulfides 225-234 fibrinogen beta chain Homo sapiens 0-10 12153599-5 2002 METHODS: We conducted a randomized, double-blind, parallel-group 16-week study evaluating the effects of methyltestosterone supplementation on plasma viscosity and fibrinogen levels in postmenopausal women already on oestrogen replacement therapy (ERT) for at least 3 months. Methyltestosterone 105-123 fibrinogen beta chain Homo sapiens 164-174 12127376-9 2002 CONCLUSIONS: These results suggest that lipid lowering with atorvastatin therapy significantly increases GFC, decreases fibrinogen levels, and causes leukocyte deactivation. Atorvastatin 60-72 fibrinogen beta chain Homo sapiens 120-130 12089331-9 2002 These results suggest that RSNOs induce changes to fibrinogen structure by interacting at specific aromatic rich domains. rsnos 27-32 fibrinogen beta chain Homo sapiens 51-61 12147794-8 2002 RESULTS: Both CR and PA were positively correlated with platelet count and fibrinogen level. Chromium 14-16 fibrinogen beta chain Homo sapiens 75-85 12147794-8 2002 RESULTS: Both CR and PA were positively correlated with platelet count and fibrinogen level. Protactinium 21-23 fibrinogen beta chain Homo sapiens 75-85 12189015-0 2002 Peroxynitrite-mediated modification of fibrinogen affects platelet aggregation and adhesion. Peroxynitrous Acid 0-13 fibrinogen beta chain Homo sapiens 39-49 12189015-1 2002 The reaction of peroxynitrite with fibrinogen resulted in both structural modifications and altered biological properties of this glycoprotein. Peroxynitrous Acid 16-29 fibrinogen beta chain Homo sapiens 35-45 12189015-2 2002 SDS-PAGE analysis of peroxynitrite-treated fibrinogen, performed under non-reducing conditions, showed some aggregated material on the top of the gel (5-10% of total staining bands) and the presence of nitrotyrosine. Sodium Dodecyl Sulfate 0-3 fibrinogen beta chain Homo sapiens 43-53 12189015-2 2002 SDS-PAGE analysis of peroxynitrite-treated fibrinogen, performed under non-reducing conditions, showed some aggregated material on the top of the gel (5-10% of total staining bands) and the presence of nitrotyrosine. Peroxynitrous Acid 21-34 fibrinogen beta chain Homo sapiens 43-53 12189015-2 2002 SDS-PAGE analysis of peroxynitrite-treated fibrinogen, performed under non-reducing conditions, showed some aggregated material on the top of the gel (5-10% of total staining bands) and the presence of nitrotyrosine. 3-nitrotyrosine 202-215 fibrinogen beta chain Homo sapiens 43-53 12189015-4 2002 In comparison with native molecule, peroxynitrite-treated fibrinogen subjected to SDS-PAGE under reducing conditions revealed not only three bands corresponding to Aalpha, Bbeta and gamma chains, but the existence of additional high molecular bands probably due to the formation of dityrosine crosslinking between fibrinogen subunits. Peroxynitrous Acid 36-49 fibrinogen beta chain Homo sapiens 58-68 12189015-4 2002 In comparison with native molecule, peroxynitrite-treated fibrinogen subjected to SDS-PAGE under reducing conditions revealed not only three bands corresponding to Aalpha, Bbeta and gamma chains, but the existence of additional high molecular bands probably due to the formation of dityrosine crosslinking between fibrinogen subunits. Peroxynitrous Acid 36-49 fibrinogen beta chain Homo sapiens 314-324 12189015-4 2002 In comparison with native molecule, peroxynitrite-treated fibrinogen subjected to SDS-PAGE under reducing conditions revealed not only three bands corresponding to Aalpha, Bbeta and gamma chains, but the existence of additional high molecular bands probably due to the formation of dityrosine crosslinking between fibrinogen subunits. Sodium Dodecyl Sulfate 82-85 fibrinogen beta chain Homo sapiens 58-68 12189015-4 2002 In comparison with native molecule, peroxynitrite-treated fibrinogen subjected to SDS-PAGE under reducing conditions revealed not only three bands corresponding to Aalpha, Bbeta and gamma chains, but the existence of additional high molecular bands probably due to the formation of dityrosine crosslinking between fibrinogen subunits. dityrosine 282-292 fibrinogen beta chain Homo sapiens 58-68 12189015-5 2002 The different susceptibility in tyrosine nitration of fibrinogen subunits was also observed. Tyrosine 32-40 fibrinogen beta chain Homo sapiens 54-64 12189015-7 2002 Peroxynitrite-treated fibrinogen in comparison with native molecule had a distinct capability to mediate platelet adhesion and aggregation. Peroxynitrous Acid 0-13 fibrinogen beta chain Homo sapiens 22-32 12189015-8 2002 Both unstimulated and ADP-activated platelets showed a reduced ability to adhere to peroxynitrite-modified fibrinogen. Peroxynitrous Acid 84-97 fibrinogen beta chain Homo sapiens 107-117 12189015-9 2002 The percentage of ADP-induced platelet aggregation decreased as a function of peroxynitrite-mediated modification of fibrinogen molecule. Adenosine Diphosphate 18-21 fibrinogen beta chain Homo sapiens 117-127 12189015-9 2002 The percentage of ADP-induced platelet aggregation decreased as a function of peroxynitrite-mediated modification of fibrinogen molecule. Peroxynitrous Acid 78-91 fibrinogen beta chain Homo sapiens 117-127 12089331-0 2002 Evidence for S-nitrosothiol-dependent changes in fibrinogen that do not involve transnitrosation or thiolation. S-Nitrosothiols 13-27 fibrinogen beta chain Homo sapiens 49-59 12089331-1 2002 S-nitrosoglutathione (GSNO, 50 microM) inhibited the initial rate of thrombin-catalyzed human and bovine fibrinogen polymerization by approximately 50% to 68% respectively. S-Nitrosoglutathione 0-20 fibrinogen beta chain Homo sapiens 105-115 12089331-1 2002 S-nitrosoglutathione (GSNO, 50 microM) inhibited the initial rate of thrombin-catalyzed human and bovine fibrinogen polymerization by approximately 50% to 68% respectively. S-Nitrosoglutathione 22-26 fibrinogen beta chain Homo sapiens 105-115 12089331-3 2002 The fact that the same concentration of GSNO had no effect on thrombin-dependent hydrolysis of tosylglycylprolylarginine-4-nitroanilide acetate suggested that this inhibition was due to GSNO-induced changes in fibrinogen structure. S-Nitrosoglutathione 186-190 fibrinogen beta chain Homo sapiens 210-220 12089331-4 2002 This result was confirmed by CD spectroscopy where GSNO or S-nitrosohomocysteine increased the alpha-helical content of fibrinogen by approximately 15% and 11%, respectively. S-Nitrosoglutathione 51-55 fibrinogen beta chain Homo sapiens 120-130 12089331-7 2002 Further evidence for fibrinogen-GSNO interactions was obtained from GSNO-dependent quenching of the intrinsic fibrinogen Trp fluorescence and the perturbation of the GSNO circular dichroic absorbance as a function of [fibrinogen]. S-Nitrosoglutathione 32-36 fibrinogen beta chain Homo sapiens 21-31 12089331-7 2002 Further evidence for fibrinogen-GSNO interactions was obtained from GSNO-dependent quenching of the intrinsic fibrinogen Trp fluorescence and the perturbation of the GSNO circular dichroic absorbance as a function of [fibrinogen]. S-Nitrosoglutathione 32-36 fibrinogen beta chain Homo sapiens 110-120 12089331-7 2002 Further evidence for fibrinogen-GSNO interactions was obtained from GSNO-dependent quenching of the intrinsic fibrinogen Trp fluorescence and the perturbation of the GSNO circular dichroic absorbance as a function of [fibrinogen]. S-Nitrosoglutathione 32-36 fibrinogen beta chain Homo sapiens 110-120 12089331-7 2002 Further evidence for fibrinogen-GSNO interactions was obtained from GSNO-dependent quenching of the intrinsic fibrinogen Trp fluorescence and the perturbation of the GSNO circular dichroic absorbance as a function of [fibrinogen]. S-Nitrosoglutathione 68-72 fibrinogen beta chain Homo sapiens 21-31 12089331-7 2002 Further evidence for fibrinogen-GSNO interactions was obtained from GSNO-dependent quenching of the intrinsic fibrinogen Trp fluorescence and the perturbation of the GSNO circular dichroic absorbance as a function of [fibrinogen]. S-Nitrosoglutathione 68-72 fibrinogen beta chain Homo sapiens 110-120 12089331-7 2002 Further evidence for fibrinogen-GSNO interactions was obtained from GSNO-dependent quenching of the intrinsic fibrinogen Trp fluorescence and the perturbation of the GSNO circular dichroic absorbance as a function of [fibrinogen]. S-Nitrosoglutathione 68-72 fibrinogen beta chain Homo sapiens 110-120 12089331-7 2002 Further evidence for fibrinogen-GSNO interactions was obtained from GSNO-dependent quenching of the intrinsic fibrinogen Trp fluorescence and the perturbation of the GSNO circular dichroic absorbance as a function of [fibrinogen]. Tryptophan 121-124 fibrinogen beta chain Homo sapiens 21-31 12089331-7 2002 Further evidence for fibrinogen-GSNO interactions was obtained from GSNO-dependent quenching of the intrinsic fibrinogen Trp fluorescence and the perturbation of the GSNO circular dichroic absorbance as a function of [fibrinogen]. Tryptophan 121-124 fibrinogen beta chain Homo sapiens 110-120 12089331-7 2002 Further evidence for fibrinogen-GSNO interactions was obtained from GSNO-dependent quenching of the intrinsic fibrinogen Trp fluorescence and the perturbation of the GSNO circular dichroic absorbance as a function of [fibrinogen]. Tryptophan 121-124 fibrinogen beta chain Homo sapiens 110-120 12089331-7 2002 Further evidence for fibrinogen-GSNO interactions was obtained from GSNO-dependent quenching of the intrinsic fibrinogen Trp fluorescence and the perturbation of the GSNO circular dichroic absorbance as a function of [fibrinogen]. S-Nitrosoglutathione 68-72 fibrinogen beta chain Homo sapiens 21-31 12089331-7 2002 Further evidence for fibrinogen-GSNO interactions was obtained from GSNO-dependent quenching of the intrinsic fibrinogen Trp fluorescence and the perturbation of the GSNO circular dichroic absorbance as a function of [fibrinogen]. S-Nitrosoglutathione 68-72 fibrinogen beta chain Homo sapiens 110-120 12089331-7 2002 Further evidence for fibrinogen-GSNO interactions was obtained from GSNO-dependent quenching of the intrinsic fibrinogen Trp fluorescence and the perturbation of the GSNO circular dichroic absorbance as a function of [fibrinogen]. S-Nitrosoglutathione 68-72 fibrinogen beta chain Homo sapiens 110-120 12089331-8 2002 The K(d)s of 3 to 10 microM for fibrinogen-GSNO interactions with a stoichiometry of 2:1 (GSNO:fibrinogen) were estimated from isothermal titration calorimetry and fluorescence quenching, respectively. S-Nitrosoglutathione 43-47 fibrinogen beta chain Homo sapiens 32-42 12089331-8 2002 The K(d)s of 3 to 10 microM for fibrinogen-GSNO interactions with a stoichiometry of 2:1 (GSNO:fibrinogen) were estimated from isothermal titration calorimetry and fluorescence quenching, respectively. S-Nitrosoglutathione 43-47 fibrinogen beta chain Homo sapiens 95-105 12351391-5 2002 Thrombospondin and fibrinogen were identified using photoreactive cross-linking to an albumin-(serotonin)(6) conjugate during COAT-platelet production. Serotonin 95-104 fibrinogen beta chain Homo sapiens 19-29 12351391-6 2002 We subsequently verified that biotin-albumin-(serotonin)(6) binds in vitro to thrombospondin, fibrinogen, and fibrinogen fragment D in a saturable manner. Biotin 30-36 fibrinogen beta chain Homo sapiens 94-104 12351391-6 2002 We subsequently verified that biotin-albumin-(serotonin)(6) binds in vitro to thrombospondin, fibrinogen, and fibrinogen fragment D in a saturable manner. Biotin 30-36 fibrinogen beta chain Homo sapiens 110-120 12351391-6 2002 We subsequently verified that biotin-albumin-(serotonin)(6) binds in vitro to thrombospondin, fibrinogen, and fibrinogen fragment D in a saturable manner. Serotonin 46-55 fibrinogen beta chain Homo sapiens 94-104 12351391-6 2002 We subsequently verified that biotin-albumin-(serotonin)(6) binds in vitro to thrombospondin, fibrinogen, and fibrinogen fragment D in a saturable manner. Serotonin 46-55 fibrinogen beta chain Homo sapiens 110-120 12351391-7 2002 These data support a model for COAT-platelets where serotonin-derivatized procoagulant proteins interact with their respective receptors (eg, fibrinogen with glycoprotein IIb/IIIa or factor V with phosphatidylserine) as well as serotonin binding sites on fibrinogen and thrombospondin, resulting in a stable, multivalent complex on the cell surface. Serotonin 52-61 fibrinogen beta chain Homo sapiens 142-152 12351391-7 2002 These data support a model for COAT-platelets where serotonin-derivatized procoagulant proteins interact with their respective receptors (eg, fibrinogen with glycoprotein IIb/IIIa or factor V with phosphatidylserine) as well as serotonin binding sites on fibrinogen and thrombospondin, resulting in a stable, multivalent complex on the cell surface. Serotonin 52-61 fibrinogen beta chain Homo sapiens 255-265 12351391-7 2002 These data support a model for COAT-platelets where serotonin-derivatized procoagulant proteins interact with their respective receptors (eg, fibrinogen with glycoprotein IIb/IIIa or factor V with phosphatidylserine) as well as serotonin binding sites on fibrinogen and thrombospondin, resulting in a stable, multivalent complex on the cell surface. Serotonin 228-237 fibrinogen beta chain Homo sapiens 142-152 12048138-9 2002 Overall, fibrinogen levels fell by 12%, with patients with the highest baseline fibrinogen levels showing the greatest decrease in response to bezafibrate. Bezafibrate 143-154 fibrinogen beta chain Homo sapiens 9-19 12048138-9 2002 Overall, fibrinogen levels fell by 12%, with patients with the highest baseline fibrinogen levels showing the greatest decrease in response to bezafibrate. Bezafibrate 143-154 fibrinogen beta chain Homo sapiens 80-90 12121135-6 2002 The competitive adsorption of BSA and bovine serum fibrinogen (Fg) in the BSA-Fg binary solutions was also studied using a (125)I-probe, and through which the reversibly BSA-selective adsorption on cibaMPEO-modified PEU surfaces was confirmed. cibampeo 198-206 fibrinogen beta chain Homo sapiens 51-61 12131916-1 2002 The purpose of the present report is to demonstrate the long-term efficacy and safety of heparin-induced extracorporeal lipoprotein precipitation (HELP) of LDL-c and fibrinogen in the management of familial hypercholesterolemia. Heparin 89-96 fibrinogen beta chain Homo sapiens 166-176 12138368-5 2002 Mg(2+) increased platelet adhesion exclusively to collagen and fibrinogen at physiologically relevant concentrations. magnesium ion 0-6 fibrinogen beta chain Homo sapiens 63-73 12138368-8 2002 Mn(2+) elicited dose-dependent adhesion only to collagen and fibrinogen. Manganese(2+) 0-6 fibrinogen beta chain Homo sapiens 61-71 12138368-12 2002 Mg(2+)-dependent platelet adhesion to collagen and Ca(2+)-dependent adhesion to fibrinogen increased P-selectin expression. magnesium ion 0-6 fibrinogen beta chain Homo sapiens 80-90 12093059-10 2002 Plasma fibrinogen decreased with sulodexide, but increased with placebo. glucuronyl glucosamine glycan sulfate 33-43 fibrinogen beta chain Homo sapiens 7-17 12093059-11 2002 CONCLUSION: Sulodexide improved the walking ability of peripheral arterial obstructive disease patients to a significantly greater extent than placebo, with a concurrent significant decrease in fibrinogen. glucuronyl glucosamine glycan sulfate 12-22 fibrinogen beta chain Homo sapiens 194-204 12091125-11 2002 The increase of the plasma fibrinogen level is mainly related to TSA and the increase of CRP, which is associated with thrombin generation. trichostatin A 65-68 fibrinogen beta chain Homo sapiens 27-37 12152651-8 2002 However, it did not prevent the conformational change in alphaIIb beta3 (shown by PAC-1 binding), although integrin affinity for fibrinogen was decreased as measured using FITC-fibrinogen. Fluorescein-5-isothiocyanate 172-176 fibrinogen beta chain Homo sapiens 177-187 12049640-4 2002 In sharp contrast, although fibrinogen binding to platelets stimulates alphaIIbbeta3-dependent activation of Syk and tyrosine phosphorylation of SLP-76 and PLCgamma2, it does not utilize GEMs to promote these responses or to support platelet aggregation. Tyrosine 117-125 fibrinogen beta chain Homo sapiens 28-38 11920657-0 2002 Platelet adhesion to polystyrene-based surfaces preadsorbed with plasmas selectively depleted in fibrinogen, fibronectin, vitronectin, or von Willebrand"s factor. Polystyrenes 21-32 fibrinogen beta chain Homo sapiens 97-107 11920657-4 2002 The aim of the current study was to assess the importance of Fg, Fn, Vn, and vWF in mediating platelet adhesion to a series of polystyrene-based surfaces. Polystyrenes 127-138 fibrinogen beta chain Homo sapiens 61-63 12355033-5 2002 Platelet reactivity was characterized with flow cytometry to quantify the percentage of platelets capable of binding fibrinogen (activation of glycoprotein IIb-IIIa) and expressing P-selectin in response to adenosine diphosphate (ADP, 0, 0.2, and 1 microM). Adenosine Diphosphate 207-228 fibrinogen beta chain Homo sapiens 117-127 12355033-6 2002 RESULTS: Platelet reactivity was greater in blood treated with UFH than in blood anticoagulated with bivalirudin with respect to both the capacity to bind fibrinogen (by 4 +/- 1.8%, p = 0.01) and P-selectin expression (by 7.7 +/- 0.7%, p, < 0.0001) in response to 1 microM ADP. Heparin 63-66 fibrinogen beta chain Homo sapiens 155-165 12355033-6 2002 RESULTS: Platelet reactivity was greater in blood treated with UFH than in blood anticoagulated with bivalirudin with respect to both the capacity to bind fibrinogen (by 4 +/- 1.8%, p = 0.01) and P-selectin expression (by 7.7 +/- 0.7%, p, < 0.0001) in response to 1 microM ADP. Adenosine Diphosphate 276-279 fibrinogen beta chain Homo sapiens 155-165 12089331-10 2002 Three such putative RSNO-binding domains have been identified in the unordered, aromatic residue-rich C-termini of the alpha-chains of fibrinogen. rsno 20-24 fibrinogen beta chain Homo sapiens 135-145 12083500-7 2002 Fibrinogen significantly decreased in sulodexide patients (p = 0.006). glucuronyl glucosamine glycan sulfate 38-48 fibrinogen beta chain Homo sapiens 0-10 12189020-10 2002 The results suggest that fibrinogen on the surface of Synthocytes can interact with GPIIb/IIIa on platelets to induce platelet activation, secretory activity and aggregation, and that ADP contributes to this process. Adenosine Diphosphate 184-187 fibrinogen beta chain Homo sapiens 25-35 11986213-3 2002 Analysis of purified fibrinogen by sodium dodecyl sulfate-polyacrylamide gel electrophoresis revealed a gamma-chain variant with an apparently higher molecular weight. Sodium Dodecyl Sulfate 35-57 fibrinogen beta chain Homo sapiens 21-31 11901150-3 2002 Thrombin recognizes fibrinogen with an extended binding surface, key elements of which are Tyr(76) in exosite I, located about 20 A away from the active site, and the aryl binding site located in close proximity to the catalytic triad. Tyrosine 91-94 fibrinogen beta chain Homo sapiens 20-30 11986213-3 2002 Analysis of purified fibrinogen by sodium dodecyl sulfate-polyacrylamide gel electrophoresis revealed a gamma-chain variant with an apparently higher molecular weight. polyacrylamide 58-72 fibrinogen beta chain Homo sapiens 21-31 11986213-8 2002 The polymerization results suggest that residue gamma309 is necessary for proper alignment of fibrinogen molecules, specifically in protofibril formation and D:D interactions. gamma309 48-56 fibrinogen beta chain Homo sapiens 94-104 11976159-5 2002 RESULTS: Postprandially, the FSR of fibrinogen was approximately 30% greater (21.5 +/- 6.6% compared with 14.1 +/- 3.6% of pool/d; P < 0.01) and glucagon concentrations were approximately 40% greater (103 +/- 20 compared with 61 +/- 13 ng/L; P < 0.015) with wine than without wine. Glucagon 148-156 fibrinogen beta chain Homo sapiens 36-46 12009956-6 2002 SDS-PAGE of the photolyzed reaction mixture revealed that gelation arises from enzyme-catalyzed cross-linking of predominately the alpha and gamma chains of fibrinogen. Sodium Dodecyl Sulfate 0-3 fibrinogen beta chain Homo sapiens 157-167 12025914-0 2002 Effect of ciprofibrate on C-reactive protein and fibrinogen levels. ciprofibrate 10-22 fibrinogen beta chain Homo sapiens 49-59 12025914-10 2002 Fibrates (with the exception of gemfibrozil) also consistently lower plasma fibrinogen levels. Gemfibrozil 32-43 fibrinogen beta chain Homo sapiens 76-86 12420057-1 2002 Fibrinogen intensified luminol-dependent chemiluminescence of blood leukocytes stimulated with opsonized zymosan. Luminol 23-30 fibrinogen beta chain Homo sapiens 0-10 12420057-1 2002 Fibrinogen intensified luminol-dependent chemiluminescence of blood leukocytes stimulated with opsonized zymosan. Zymosan 105-112 fibrinogen beta chain Homo sapiens 0-10 11971003-4 2002 IL-8-stimulated neutrophil adhesion to fibrinogen was blocked 50% by the MAPK/extracellular signal-related kinase-activating enzyme inhibitor PD098059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 142-150 fibrinogen beta chain Homo sapiens 39-49 12193970-0 2002 [Fibrinogen variation: a heterozygote dysfibrinogenemia with Arg-->His substitution in position 16 of the Aalpha chain]. Arginine 61-64 fibrinogen beta chain Homo sapiens 1-11 12073623-5 2002 Prior to prednisolone therapy L-SIPA, which was thought to be affected by fibrinogen (Fbg) levels, was significantly increased in both patient groups compared to normal controls (17.4 +/- 4.1% vs. 3.6 +/- 0.7%, ND vs control, p < 0.01: 11.7 +/- 3% vs. 2 +/- 0.7%, DR vs control, p < 0.01) with values declining at weekly intervals thereafter. l-sipa 30-36 fibrinogen beta chain Homo sapiens 74-84 12073623-5 2002 Prior to prednisolone therapy L-SIPA, which was thought to be affected by fibrinogen (Fbg) levels, was significantly increased in both patient groups compared to normal controls (17.4 +/- 4.1% vs. 3.6 +/- 0.7%, ND vs control, p < 0.01: 11.7 +/- 3% vs. 2 +/- 0.7%, DR vs control, p < 0.01) with values declining at weekly intervals thereafter. l-sipa 30-36 fibrinogen beta chain Homo sapiens 86-89 12073623-9 2002 These results indicate that SIPA is enhanced in the acute stage of childhood MCNS, especially L-SIPA prior to the initiation of prednisolone therapy and H-SIPA after 1 week of prednisolone therapy, and that these phenomena may be affected by plasma Fbg and VWF levels, respectively. sipa 28-32 fibrinogen beta chain Homo sapiens 249-252 12062406-5 2002 It was found that Oregon Green 488-labeled human fibrinogen specifically binds rat erythrocyte membranes with a Kd of 1.3 microM. Oregon Green 488 carboxylic acid 18-34 fibrinogen beta chain Homo sapiens 49-59 11955079-3 2002 We have examined variant fibrinogens with alanine at position gamma318 and/or gamma320 and found that calcium binding, fibrin polymerization, and fibrinogen-mediated platelet aggregation, but not FXIIIa-catalyzed cross-linking, were abnormal. Alanine 42-49 fibrinogen beta chain Homo sapiens 25-35 11955079-3 2002 We have examined variant fibrinogens with alanine at position gamma318 and/or gamma320 and found that calcium binding, fibrin polymerization, and fibrinogen-mediated platelet aggregation, but not FXIIIa-catalyzed cross-linking, were abnormal. gamma318 62-70 fibrinogen beta chain Homo sapiens 25-35 11955079-3 2002 We have examined variant fibrinogens with alanine at position gamma318 and/or gamma320 and found that calcium binding, fibrin polymerization, and fibrinogen-mediated platelet aggregation, but not FXIIIa-catalyzed cross-linking, were abnormal. Calcium 102-109 fibrinogen beta chain Homo sapiens 25-35 12062406-6 2002 Further experiments showed that the peptide Arg-Gly-Asp-Ser blocked both fibrinogen-induced aggregation of intact erythrocytes and specific binding of fibrinogen to the erythrocyte membranes. Arginine 44-47 fibrinogen beta chain Homo sapiens 73-83 12062406-6 2002 Further experiments showed that the peptide Arg-Gly-Asp-Ser blocked both fibrinogen-induced aggregation of intact erythrocytes and specific binding of fibrinogen to the erythrocyte membranes. Arginine 44-47 fibrinogen beta chain Homo sapiens 151-161 12062406-6 2002 Further experiments showed that the peptide Arg-Gly-Asp-Ser blocked both fibrinogen-induced aggregation of intact erythrocytes and specific binding of fibrinogen to the erythrocyte membranes. Glycine 48-51 fibrinogen beta chain Homo sapiens 73-83 12062406-6 2002 Further experiments showed that the peptide Arg-Gly-Asp-Ser blocked both fibrinogen-induced aggregation of intact erythrocytes and specific binding of fibrinogen to the erythrocyte membranes. Glycine 48-51 fibrinogen beta chain Homo sapiens 151-161 12062406-6 2002 Further experiments showed that the peptide Arg-Gly-Asp-Ser blocked both fibrinogen-induced aggregation of intact erythrocytes and specific binding of fibrinogen to the erythrocyte membranes. Aspartic Acid 52-55 fibrinogen beta chain Homo sapiens 73-83 12062406-6 2002 Further experiments showed that the peptide Arg-Gly-Asp-Ser blocked both fibrinogen-induced aggregation of intact erythrocytes and specific binding of fibrinogen to the erythrocyte membranes. Aspartic Acid 52-55 fibrinogen beta chain Homo sapiens 151-161 12062406-6 2002 Further experiments showed that the peptide Arg-Gly-Asp-Ser blocked both fibrinogen-induced aggregation of intact erythrocytes and specific binding of fibrinogen to the erythrocyte membranes. Serine 56-59 fibrinogen beta chain Homo sapiens 73-83 12062406-6 2002 Further experiments showed that the peptide Arg-Gly-Asp-Ser blocked both fibrinogen-induced aggregation of intact erythrocytes and specific binding of fibrinogen to the erythrocyte membranes. Serine 56-59 fibrinogen beta chain Homo sapiens 151-161 12182905-8 2002 RESULTS: Insulin enhanced ADP-induced platelet fibrinogen binding in both Type 1 DM patients and healthy subjects. Adenosine Diphosphate 26-29 fibrinogen beta chain Homo sapiens 47-57 12182905-9 2002 For example, ADP-stimulated platelet fibrinogen BI increased from 4.25 +/- 0.74 to 8.63 +/- 2.00 with 10 microU/ml insulin (P < .05) in Type 1 DM patients. Adenosine Diphosphate 13-16 fibrinogen beta chain Homo sapiens 37-47 11991216-0 2002 Losartan and perindopril effects on plasma plasminogen activator inhibitor-1 and fibrinogen in hypertensive type 2 diabetic patients. Losartan 0-8 fibrinogen beta chain Homo sapiens 81-91 12180497-9 2002 We have developed a flow cytometry assay for measuring porcine platelet activation utilising an FITC-labelled chicken anti-fibrinogen antibody. Fluorescein-5-isothiocyanate 96-100 fibrinogen beta chain Homo sapiens 123-133 12180497-10 2002 ADP, ristocetin and thrombin induce fibrinogen binding to porcine platelets similarly to human platelets. Adenosine Diphosphate 0-3 fibrinogen beta chain Homo sapiens 36-46 12180497-10 2002 ADP, ristocetin and thrombin induce fibrinogen binding to porcine platelets similarly to human platelets. Ristocetin 5-15 fibrinogen beta chain Homo sapiens 36-46 11991216-0 2002 Losartan and perindopril effects on plasma plasminogen activator inhibitor-1 and fibrinogen in hypertensive type 2 diabetic patients. Perindopril 13-24 fibrinogen beta chain Homo sapiens 81-91 11959152-10 2002 A significant correlation between serum cortisol levels and some markers of the inflammatory response, such as fever, fibrinogen level, white blood cell (WBC) count, and beta-thromboglobulin level, was established in stroke patients. Hydrocortisone 40-48 fibrinogen beta chain Homo sapiens 118-128 11922467-0 2002 Apoptosis and cytokine release in human monocytes cultured on polystyrene and fibrinogen-coated polystyrene surfaces. Polystyrenes 96-107 fibrinogen beta chain Homo sapiens 78-88 11916936-6 2002 In contrast to PAI-1, the association of CRP and fibrinogen with incident diabetes was significantly attenuated after adjustment for body fat (BMI or waist circumference) or insulin sensitivity (S(I)), as assessed by a frequently sampled intravenous glucose tolerance test. Glucose 250-257 fibrinogen beta chain Homo sapiens 49-59 11922467-8 2002 Precoating of PS with fibrinogen revealed an enhanced cell adhesion and a concomitant reduction of CD14 expression. Polystyrenes 14-16 fibrinogen beta chain Homo sapiens 22-32 11922467-10 2002 The proportions of TdT, annexin-V and PI positive cells were unaltered or reduced on fibrinogen-coated PS in both unstimulated and agonist-challenged cultures. Polystyrenes 103-105 fibrinogen beta chain Homo sapiens 85-95 11924587-10 2002 The polymeric surfaces with immobilized PAS had better nonthrombogenic characteristics as indicated by the low platelet adhesion, high adsorption of albumin relatively to fibrinogen and low thrombus formation, making them potentially good candidates for biomedical applications. Protactinium 40-43 fibrinogen beta chain Homo sapiens 171-181 12121059-3 2002 Clopidogrel is a ticlopidin-related antiplatelet drug, with the same mechanism of action; it reduces the expression of the glycoprotein IIb/IIIa, the fibrinogen receptor on the platelet surface. Clopidogrel 0-11 fibrinogen beta chain Homo sapiens 150-160 12121059-3 2002 Clopidogrel is a ticlopidin-related antiplatelet drug, with the same mechanism of action; it reduces the expression of the glycoprotein IIb/IIIa, the fibrinogen receptor on the platelet surface. Ticlopidine 17-27 fibrinogen beta chain Homo sapiens 150-160 11959386-8 2002 Fibrinogen was associated with alcohol consumption (inversely, P=0.0001) and smoking (P=0.0598) (R2=0.06). Alcohols 31-38 fibrinogen beta chain Homo sapiens 0-10 11956665-5 2002 RESULTS: Folate treatment resulted in a significant decrease of tHcy and fibrinogen, while plasminogen and antithrombin III significantly increased. Folic Acid 9-15 fibrinogen beta chain Homo sapiens 73-83 12005182-0 2002 Sulfite induces adherence of polymorphonuclear neutrophils to immobilized fibrinogen through activation of Mac-1 beta2-integrin (CD11b/CD18). Sulfites 0-7 fibrinogen beta chain Homo sapiens 74-84 12008948-3 2002 [Proc Natl Acad Sci (USA) 95: 1438, 1998] observed that fibrinogen fibrils that had been assembled on a fibrin fragment E template, cross-linked with factor XIIIa, and then dissociated in acetic acid solution, were aligned end-to-end. Acetic Acid 188-199 fibrinogen beta chain Homo sapiens 56-66 11830467-0 2002 A functional platelet fibrinogen receptor with a deletion in the cysteine-rich repeat region of the beta(3) integrin: the Oe(a) alloantigen in neonatal alloimmune thrombocytopenia. Cysteine 65-73 fibrinogen beta chain Homo sapiens 22-32 11877267-7 2002 Reviparin administered twice daily plus vitamin K antagonist is more effective in inhibiting in vivo thrombin generation compared to intravenous unfractionated heparin plus vitamin K antagonist, and reviparin once daily produced significantly higher TFPI release and greater reduction in TAFI and fibrinogen levels. reviparin 0-9 fibrinogen beta chain Homo sapiens 297-307 11877267-7 2002 Reviparin administered twice daily plus vitamin K antagonist is more effective in inhibiting in vivo thrombin generation compared to intravenous unfractionated heparin plus vitamin K antagonist, and reviparin once daily produced significantly higher TFPI release and greater reduction in TAFI and fibrinogen levels. reviparin 199-208 fibrinogen beta chain Homo sapiens 297-307 11942772-9 2002 CONCLUSION: Fenofibrate and gemfibrozil induced similar variations from baseline values in triglycerides, HDL cholesterol, apolipoprotein B, and fibrinogen, but the decreases in total and LDL cholesterol levels were greater with fenofibrate, in this group of patients with primary hyperlipidemia. Fenofibrate 12-23 fibrinogen beta chain Homo sapiens 145-155 11942772-9 2002 CONCLUSION: Fenofibrate and gemfibrozil induced similar variations from baseline values in triglycerides, HDL cholesterol, apolipoprotein B, and fibrinogen, but the decreases in total and LDL cholesterol levels were greater with fenofibrate, in this group of patients with primary hyperlipidemia. Gemfibrozil 28-39 fibrinogen beta chain Homo sapiens 145-155 11950049-6 2002 Precoating of the polymer surfaces with human serum albumin (HSA) or fibrinogen, markedly reduced neutrophil activation, whereas coating with human immunoglobulin G (IgG), a well-known opsonin, resulted in significantly higher levels of cell activation. Polymers 18-25 fibrinogen beta chain Homo sapiens 46-79 11896934-1 2002 The aim of this study was to investigate whether neutrophil adhesion to extracellular matrix proteins like fibronectin, fibrinogen, and albumin influence the release proteins from primary and secondary granules of neutrophils stimulated by phorbol-myristate-acetate (PMA) and formyl-methionyl-leucyl-phenylalanine (f-MLP). Tetradecanoylphorbol Acetate 240-265 fibrinogen beta chain Homo sapiens 120-130 11815639-13 2002 Associations between fibrinogen and stroke were similar across strata of smoking, diabetes mellitus, previous myocardial infarction, and HDL cholesterol. Cholesterol 141-152 fibrinogen beta chain Homo sapiens 21-31 11812234-7 2002 Moreover, both enzymes were active against a broad spectrum of biological and synthetic substrates such as mucin, fibrinogen, collagen, human hemoglobin, bovine serum albumin, gelatin, human IgG, Z-Arg-Arg-pNA, and Z-Ala-Arg-Arg-pNA, but not against Z-Phe-Arg-pNA. z-ala-arg-arg-pna 215-232 fibrinogen beta chain Homo sapiens 114-124 11812234-7 2002 Moreover, both enzymes were active against a broad spectrum of biological and synthetic substrates such as mucin, fibrinogen, collagen, human hemoglobin, bovine serum albumin, gelatin, human IgG, Z-Arg-Arg-pNA, and Z-Ala-Arg-Arg-pNA, but not against Z-Phe-Arg-pNA. Z-Phe-Arg-PNA 250-263 fibrinogen beta chain Homo sapiens 114-124 11931374-2 2002 For extracorporeal adsorption of fibrinogen the pentapeptide gly-pro-arg-pro-lys was coupled to sepharose CL-4B. Gly-Pro-Arg-Pro-Lys 61-80 fibrinogen beta chain Homo sapiens 33-43 11931374-2 2002 For extracorporeal adsorption of fibrinogen the pentapeptide gly-pro-arg-pro-lys was coupled to sepharose CL-4B. Sepharose CL 4B 96-111 fibrinogen beta chain Homo sapiens 33-43 11931374-20 2002 In conclusion, affinity chromatography using the pentapeptide gly-pro-arg-pro-lys is an effective, selective and safe procedure to lower fibrinogen concentration in plasma thereby improving blood viscosity. Gly-Pro-Arg-Pro-Lys 62-81 fibrinogen beta chain Homo sapiens 137-147 11805836-6 2002 Serotonin, an abundant component of platelet-dense granules, has an Mr of 176, and fibrinogen isolated from COAT-platelets contains covalently linked serotonin. Serotonin 150-159 fibrinogen beta chain Homo sapiens 83-93 11755933-4 2002 Fibrinogen concentrations were higher at baseline among individuals treated with statins (n=130) compared to those treated with fibrates (n=251), even after adjustment for confounding factors (including total cholesterol, HDL cholesterol and triglycerides) (mean (S.D. Cholesterol 209-220 fibrinogen beta chain Homo sapiens 0-10 11755933-4 2002 Fibrinogen concentrations were higher at baseline among individuals treated with statins (n=130) compared to those treated with fibrates (n=251), even after adjustment for confounding factors (including total cholesterol, HDL cholesterol and triglycerides) (mean (S.D. Cholesterol 226-237 fibrinogen beta chain Homo sapiens 0-10 11755933-4 2002 Fibrinogen concentrations were higher at baseline among individuals treated with statins (n=130) compared to those treated with fibrates (n=251), even after adjustment for confounding factors (including total cholesterol, HDL cholesterol and triglycerides) (mean (S.D. Triglycerides 242-255 fibrinogen beta chain Homo sapiens 0-10 11755933-7 2002 After adjustment for baseline fibrinogen level, age, sex and changes in total cholesterol, triglycerides and alcohol intake, fibrinogen concentration decreased after fibrate treatment, while it increased after statin treatment and in those not using lipid lowering drugs (-0.07 (0.54) vs. 0.10 (0.54) vs. 0.08 (0.52) g/l respectively, P=0.01). Triglycerides 91-104 fibrinogen beta chain Homo sapiens 125-135 11755933-7 2002 After adjustment for baseline fibrinogen level, age, sex and changes in total cholesterol, triglycerides and alcohol intake, fibrinogen concentration decreased after fibrate treatment, while it increased after statin treatment and in those not using lipid lowering drugs (-0.07 (0.54) vs. 0.10 (0.54) vs. 0.08 (0.52) g/l respectively, P=0.01). Alcohols 109-116 fibrinogen beta chain Homo sapiens 125-135 11994570-8 2002 Pathological samples showed an overestimation of fibrinogen when using PTd measurements in patients treated with vitamin K antagonists, as well as when using aPTTd measurements in patients presenting with factor VIII and factor IX deficiencies. Vitamin K 113-122 fibrinogen beta chain Homo sapiens 49-59 11761163-6 2002 This study showed significant differences in adsorption patterns among the heparin-coated and the uncoated surfaces, notably for fibronectin, fibrinogen, C3 and high molecular weight kininogen (HMWK). Heparin 75-82 fibrinogen beta chain Homo sapiens 142-152 11904470-4 2002 From all the biological variables analyzed (cholesterol, triglycerides, glucose, fibrinogen, erythrocyte aggregation, hematocrit, plasma viscosity and PAI-1) only fibrinogen concentration reached a statistically significant difference on the comparison of means (290+/-73 mg/dl in cases vs 268+/-58 mg/dl in controls, p<0.05). Cholesterol 44-55 fibrinogen beta chain Homo sapiens 163-173 12778954-0 2002 The minimum concentration of fibrinogen needed for platelet aggregation using ADP. Adenosine Diphosphate 78-81 fibrinogen beta chain Homo sapiens 29-39 12017210-9 2002 The addition of micronised fenofibrate significantly decreased plasma fibrinogen levels as well as total cholesterol, low-density lipoprotein cholesterol, apolipoprotein B (ApoB) and triglycerides, and increased high-density lipoprotein cholesterol and ApoA, levels. Fenofibrate 27-38 fibrinogen beta chain Homo sapiens 70-80 12094825-0 2002 The effect of fluvastatin on plasma fibrinogen levels. Fluvastatin 14-25 fibrinogen beta chain Homo sapiens 36-46 12094825-1 2002 There are conflicting data with regard to the effect of statins, including fluvastatin, on plasma fibrinogen levels. Fluvastatin 75-86 fibrinogen beta chain Homo sapiens 98-108 12094825-2 2002 We undertook the present study to examine the influence of fluvastatin (40 mg/day) on plasma fibrinogen levels in hypercholesterolemic non-smoker patients with normal triglyceride levels (< 2.25 mmol/l) (n = 65). Fluvastatin 59-70 fibrinogen beta chain Homo sapiens 93-103 12094825-3 2002 Fluvastatin administration was followed by a significant decrease of plasma fibrinogen levels by 8% (from 3.6 g/l to 3.33 g/l median value, p < 0.02). Fluvastatin 0-11 fibrinogen beta chain Homo sapiens 76-86 12094825-8 2002 Furthermore, in some of these studies, which Included relatively small numbers of patients, there was a trend towards a decrease in plasma fibrinogen concentration after fluvastatin administration. Fluvastatin 170-181 fibrinogen beta chain Homo sapiens 139-149 12094825-9 2002 We conclude that fluvastatin can significantly decrease plasma fibrinogen levels. Fluvastatin 17-28 fibrinogen beta chain Homo sapiens 63-73 11939455-4 2002 The ability of the selected PUs to adsorb human fibronectin (Fn) and fibrinogen (Fbg) was checked by ELISA with biotin-labelled proteins. Biotin 112-118 fibrinogen beta chain Homo sapiens 81-84 12182554-0 2002 Fibrinogen adsorption by PS latex particles coated with various amounts of a PEO/PPO/PEO triblock copolymer. styrofoam 25-33 fibrinogen beta chain Homo sapiens 0-10 12182554-0 2002 Fibrinogen adsorption by PS latex particles coated with various amounts of a PEO/PPO/PEO triblock copolymer. triblock copolymer 89-107 fibrinogen beta chain Homo sapiens 0-10 12182554-4 2002 An increase in the copolymer surface concentration on 252-nm particles was found to decrease their fibrinogen uptake exponentially. copolymer 19-28 fibrinogen beta chain Homo sapiens 99-109 12182554-5 2002 At maximum copolymer surface concentration, the fibrinogen uptake was two orders of magnitude lower than that of bare particles (down from 3.3 mg/m2 to 0.03 mg/m2). copolymer 11-20 fibrinogen beta chain Homo sapiens 48-58 12182554-10 2002 Results obtained with F108 coated particles of different sizes showed that particle size had a significant effect on the fibrinogen uptake, with larger particles showing larger fibrinogen uptakes. FS-108 22-26 fibrinogen beta chain Homo sapiens 121-131 12182557-7 2002 Fibrinogen, an adhesive protein for further cellular adhesion and activation, was effectively repelled by increasing the amount of copolymer additive. copolymer 131-140 fibrinogen beta chain Homo sapiens 0-10 12182558-3 2002 The purpose of this study was to examine the effects of co-adsorbed proteins and shear forces on such time-dependent functional changes in fibrinogen adsorbed onto polyethylene (PE), polytetrafluoroethylene (PTFE), and silicone rubber (SR). Polyethylene 164-176 fibrinogen beta chain Homo sapiens 139-149 12182558-3 2002 The purpose of this study was to examine the effects of co-adsorbed proteins and shear forces on such time-dependent functional changes in fibrinogen adsorbed onto polyethylene (PE), polytetrafluoroethylene (PTFE), and silicone rubber (SR). Polyethylene 178-180 fibrinogen beta chain Homo sapiens 139-149 12182558-3 2002 The purpose of this study was to examine the effects of co-adsorbed proteins and shear forces on such time-dependent functional changes in fibrinogen adsorbed onto polyethylene (PE), polytetrafluoroethylene (PTFE), and silicone rubber (SR). Polytetrafluoroethylene 208-212 fibrinogen beta chain Homo sapiens 139-149 12182558-3 2002 The purpose of this study was to examine the effects of co-adsorbed proteins and shear forces on such time-dependent functional changes in fibrinogen adsorbed onto polyethylene (PE), polytetrafluoroethylene (PTFE), and silicone rubber (SR). Silicone Elastomers 219-234 fibrinogen beta chain Homo sapiens 139-149 12182558-3 2002 The purpose of this study was to examine the effects of co-adsorbed proteins and shear forces on such time-dependent functional changes in fibrinogen adsorbed onto polyethylene (PE), polytetrafluoroethylene (PTFE), and silicone rubber (SR). Silicone Elastomers 236-238 fibrinogen beta chain Homo sapiens 139-149 12182558-5 2002 Changes in fibrinogen reactivity were determined by measuring the adhesion of 51Cr-labeled platelets and the ability of blood plasma to displace previously adsorbed fibrinogen. Chromium-51 78-82 fibrinogen beta chain Homo sapiens 11-21 12462462-0 2002 Fibrinogen adsorption and platelet interactions on polymer membranes. Polymers 51-58 fibrinogen beta chain Homo sapiens 0-10 15348209-4 2002 Protein adsorption studies using fibrinogen and albumin, two proteins implicated in cellular adhesion and surface activity, reveal that low stress silicon nitride surfaces have a 223%+/-2.50% greater protein adsorption compared to undoped polysilicon surfaces, followed by silicon nitride, unmodified silicon, and doped polysilicon surfaces, respectively. silicon nitride 147-162 fibrinogen beta chain Homo sapiens 33-43 12439349-2 2002 Alcohol consumption reduces cardiovascular disease risk primarily by increasing production of high-density lipoprotein cholesterol, and possibly by increasing plasminogen, tissue plasminogen activator, and endothelial function, and decreasing platelet aggregability, fibrinogen, and lipoprotein(a). Alcohols 0-7 fibrinogen beta chain Homo sapiens 267-277 11784625-6 2001 FINDINGS: On univariate analysis, ADMA concentration in plasma was directly related to concentrations of fibrinogen and L-arginine in plasma, duration of dialysis treatment, and serum cholesterol concentration, and was inversely related to serum albumin concentration. N,N-dimethylarginine 34-38 fibrinogen beta chain Homo sapiens 105-115 11784625-7 2001 On multivariate analysis, only plasma fibrinogen (p=0.0001) and serum albumin (p=0.04) concentrations were independently related to plasma ADMA concentration (multiple r=0.44, p=0.0001). N,N-dimethylarginine 139-143 fibrinogen beta chain Homo sapiens 38-48 11755207-0 2001 Gamma371 Thr-->Ile substitution in the fibrinogen gammaD domain causes hypofibrinogenaemia. Threonine 9-12 fibrinogen beta chain Homo sapiens 39-49 11755207-0 2001 Gamma371 Thr-->Ile substitution in the fibrinogen gammaD domain causes hypofibrinogenaemia. Isoleucine 15-18 fibrinogen beta chain Homo sapiens 39-49 11755951-11 2001 A positive correlation was found between fibrinogen and SA levels (r=.5, P<.01). N-Acetylneuraminic Acid 56-58 fibrinogen beta chain Homo sapiens 41-51 11717083-6 2001 Specifically, a positive relationship was found between the use of dehydrated alcohol or sodium tetradecyl sulfate and a disruption in coagulation profiles as evidenced by a decrease in platelets and fibrinogen, an increase in prothrombin time, and a conversion from negative to positive d-dimers. Alcohols 78-85 fibrinogen beta chain Homo sapiens 200-210 11717083-6 2001 Specifically, a positive relationship was found between the use of dehydrated alcohol or sodium tetradecyl sulfate and a disruption in coagulation profiles as evidenced by a decrease in platelets and fibrinogen, an increase in prothrombin time, and a conversion from negative to positive d-dimers. Sodium Tetradecyl Sulfate 89-114 fibrinogen beta chain Homo sapiens 200-210 11770189-10 2001 Fibrinogen fell by 7.0% with raloxifene and rose by 3.6% with ccHRT. Raloxifene Hydrochloride 29-39 fibrinogen beta chain Homo sapiens 0-10 11770189-10 2001 Fibrinogen fell by 7.0% with raloxifene and rose by 3.6% with ccHRT. cchrt 62-67 fibrinogen beta chain Homo sapiens 0-10 11770189-12 2001 The smaller decreases in total cholesterol and LDL cholesterol associated with raloxifene were accompanied by an increase in HDL cholesterol and a decrease in fibrinogen. Cholesterol 51-62 fibrinogen beta chain Homo sapiens 159-169 11770189-12 2001 The smaller decreases in total cholesterol and LDL cholesterol associated with raloxifene were accompanied by an increase in HDL cholesterol and a decrease in fibrinogen. Raloxifene Hydrochloride 79-89 fibrinogen beta chain Homo sapiens 159-169 11770189-12 2001 The smaller decreases in total cholesterol and LDL cholesterol associated with raloxifene were accompanied by an increase in HDL cholesterol and a decrease in fibrinogen. Cholesterol 51-62 fibrinogen beta chain Homo sapiens 159-169 11770189-13 2001 In conclusion, raloxifene affects fibrinogen concentrations and the overall cholesterol profile more favorably than ccHRT; these differences may have important implications for the reduction of cardiovascular disease. Raloxifene Hydrochloride 15-25 fibrinogen beta chain Homo sapiens 34-44 11711274-3 2001 We tested the hypothesis that serum TSA and other acute phase proteins, namely C-reactive protein (CRP) and fibrinogen, may be related to the postprandial state. trichostatin A 36-39 fibrinogen beta chain Homo sapiens 108-118 11711274-9 2001 There was a significant correlation between serum TSA and plasma fibrinogen at baseline (rho=0.62, P=0.05) but not for serum CRP (rho=-0.22) or triglyceride (rho=0.21). trichostatin A 50-53 fibrinogen beta chain Homo sapiens 65-75 11770837-9 2001 Compared with the control subjects (2.91 +/- 0.35 g/l), fibrinogen levels before treatment were higher in patients with dyslipidemia treated with ciprofibrate (3.42 +/- 0.59 g/l, NS) and fenofibrate (3.65 +/- 1.10 g/l, p < 0.05). ciprofibrate 146-158 fibrinogen beta chain Homo sapiens 56-66 11770837-9 2001 Compared with the control subjects (2.91 +/- 0.35 g/l), fibrinogen levels before treatment were higher in patients with dyslipidemia treated with ciprofibrate (3.42 +/- 0.59 g/l, NS) and fenofibrate (3.65 +/- 1.10 g/l, p < 0.05). Fenofibrate 187-198 fibrinogen beta chain Homo sapiens 56-66 11770837-10 2001 One-month ciprofibrate treatment resulted in an insignificant decrease in PAI-1 levels (76.28 21.60 ng/ml, NS) and in a significant decrease in fibrinogen levels (2.73 +/- 0.40 g/l, p < 0.01). ciprofibrate 10-22 fibrinogen beta chain Homo sapiens 144-154 11707691-3 2001 We tested the effects of GTC on the aggregation of human platelets and on the binding of fluorescein isothiocyanate-conjugated fibrinogen to human platelet glycoprotein (GP) IIb/IIIa. Fluorescein-5-isothiocyanate 89-115 fibrinogen beta chain Homo sapiens 127-137 11707691-11 2001 Taken together, these observations suggest that the antiplatelet activity of GTC is be mediated by inhibition of cytoplasmic calcium increase, which leads to the inhibition of fibrinogen-GPIIb/IIIa binding via the activation of Ca(2+)-ATPase and inhibition of IP(3) formation. Calcium 125-132 fibrinogen beta chain Homo sapiens 176-186 11791309-0 2001 [Effect of fibrinogen on corrosion behavior of stainless steel in artificial blood solution]. Stainless Steel 47-62 fibrinogen beta chain Homo sapiens 11-21 11791309-1 2001 The effect of fibrinogen on corrosion behavior of SUS316L and SUS317L stainless steel in artificial blood PBS solution has been investigated with electrochemical technology. SUS 316L 50-57 fibrinogen beta chain Homo sapiens 14-24 11791309-1 2001 The effect of fibrinogen on corrosion behavior of SUS316L and SUS317L stainless steel in artificial blood PBS solution has been investigated with electrochemical technology. sus317l 62-69 fibrinogen beta chain Homo sapiens 14-24 11791309-1 2001 The effect of fibrinogen on corrosion behavior of SUS316L and SUS317L stainless steel in artificial blood PBS solution has been investigated with electrochemical technology. Stainless Steel 70-85 fibrinogen beta chain Homo sapiens 14-24 11791309-2 2001 The results showed that the corrosion potential (Ec) of stainless steel shifted negatively, the passivated current (ip) became less and the pitting corrosion potential (Eb) shifted negatively with the existence of fibrinogen in PBS. Stainless Steel 56-71 fibrinogen beta chain Homo sapiens 214-224 11791309-2 2001 The results showed that the corrosion potential (Ec) of stainless steel shifted negatively, the passivated current (ip) became less and the pitting corrosion potential (Eb) shifted negatively with the existence of fibrinogen in PBS. Lead 228-231 fibrinogen beta chain Homo sapiens 214-224 11791309-4 2001 SEM pictures demonstrated that stainless steel adsorbed fibrinogen on its surface. Stainless Steel 31-46 fibrinogen beta chain Homo sapiens 56-66 11776317-3 2001 The new dysfunctional fibrinogen, San Giovanni Rotondo variant, was confirmed in vivo by SDS-PAGE analysis of HPLC-purified fibrinogen chains. Sodium Dodecyl Sulfate 89-92 fibrinogen beta chain Homo sapiens 22-32 11778070-1 2001 BACKGROUND: Photodynamic virus inactivation of plasma with methylene blue significantly decreases the recovery of fibrinogen and coagulation factors V and VIII. Methylene Blue 59-73 fibrinogen beta chain Homo sapiens 114-124 11778070-2 2001 Because an adequate supply of fibrinogen is essential for the therapeutic efficacy of transfused plasma in many clinical settings, it was plausible that transfusing photoinactivated plasma (PIP) instead of FFP would result in an increased demand for plasma and cryoprecipitate. pip 190-193 fibrinogen beta chain Homo sapiens 30-40 11723016-5 2001 In the Pl(A1A1) homozygotes, aspirin ingestion resulted in reductions in the velocity of thrombin B-chain formation (by 32.1%; P=0.007), prothrombin consumption (by 30.4%; P=0.018), factor Va generation (by 28.9%; P=0.014), fibrinogen removal (by 41.2%; P=0.001), and factor XIII activation (by 22.6%; P=0.026). Aspirin 29-36 fibrinogen beta chain Homo sapiens 224-234 11728532-9 2001 RESULTS: In a drug free group, digestion of a single tablet of aspirin resulted in a significantly (p<0.05) diminished expression of PECAM-1, GP IIb, fibrinogen binding with PAC-1 antibody, GP Ib, P-selectin, and CD151. Aspirin 63-70 fibrinogen beta chain Homo sapiens 153-163 11672762-5 2001 Platelet fibrinogen binding and P-selectin expression were significantly lower in patients treated with ticlopidine but not with aspirin than in those not treated with any antiplatelet agent, and were lowest in those treated with both ticlopidine and aspirin. Ticlopidine 104-115 fibrinogen beta chain Homo sapiens 9-19 11711499-6 2001 HDL cholesterol was lower and plasma creatinine and urinary albumin/creatinine ratio was higher in the third tertile of fibrinogen. Cholesterol 4-15 fibrinogen beta chain Homo sapiens 120-130 11711499-6 2001 HDL cholesterol was lower and plasma creatinine and urinary albumin/creatinine ratio was higher in the third tertile of fibrinogen. Creatinine 37-47 fibrinogen beta chain Homo sapiens 120-130 11711499-6 2001 HDL cholesterol was lower and plasma creatinine and urinary albumin/creatinine ratio was higher in the third tertile of fibrinogen. Creatinine 68-78 fibrinogen beta chain Homo sapiens 120-130 11674861-5 2001 Wortmannin (25, 50 and 100 nM, 30 min, 37 degrees C) caused a reduction of platelet adhesion to fibrinogen (P<0.01) when blood platelets were stimulated by both 0.2 U/ml thrombin (IC(50)approximately 75 nM) and by 1 microM ADP (IC(50)approximately 60 nM). Wortmannin 0-10 fibrinogen beta chain Homo sapiens 96-106 11674861-7 2001 The potentiated by CP adhesion of activated platelets to fibrinogen was reduced after preincubation of platelets with wortmannin (50 nM, 30 min, 37 degrees C). Wortmannin 118-128 fibrinogen beta chain Homo sapiens 57-67 11672762-5 2001 Platelet fibrinogen binding and P-selectin expression were significantly lower in patients treated with ticlopidine but not with aspirin than in those not treated with any antiplatelet agent, and were lowest in those treated with both ticlopidine and aspirin. Aspirin 129-136 fibrinogen beta chain Homo sapiens 9-19 11672762-5 2001 Platelet fibrinogen binding and P-selectin expression were significantly lower in patients treated with ticlopidine but not with aspirin than in those not treated with any antiplatelet agent, and were lowest in those treated with both ticlopidine and aspirin. Ticlopidine 235-246 fibrinogen beta chain Homo sapiens 9-19 11672762-5 2001 Platelet fibrinogen binding and P-selectin expression were significantly lower in patients treated with ticlopidine but not with aspirin than in those not treated with any antiplatelet agent, and were lowest in those treated with both ticlopidine and aspirin. Aspirin 251-258 fibrinogen beta chain Homo sapiens 9-19 11583726-2 2001 Using a copper mediated cell free system to oxidize beta-lipoproteins, we found that beta -lipoproteins isolated from plasma were less susceptible to oxidation than lipoproteins from serum and that this was probably due to inhibition by fibrinogen, because removal of fibrinogen from plasma enhanced oxidation, while addition of fibrinogen restored inhibition. Copper 8-14 fibrinogen beta chain Homo sapiens 237-247 11712826-8 2001 Fibrinogen inversely correlated with alcohol consumption. Alcohols 37-44 fibrinogen beta chain Homo sapiens 0-10 11583726-2 2001 Using a copper mediated cell free system to oxidize beta-lipoproteins, we found that beta -lipoproteins isolated from plasma were less susceptible to oxidation than lipoproteins from serum and that this was probably due to inhibition by fibrinogen, because removal of fibrinogen from plasma enhanced oxidation, while addition of fibrinogen restored inhibition. Copper 8-14 fibrinogen beta chain Homo sapiens 268-278 11583726-2 2001 Using a copper mediated cell free system to oxidize beta-lipoproteins, we found that beta -lipoproteins isolated from plasma were less susceptible to oxidation than lipoproteins from serum and that this was probably due to inhibition by fibrinogen, because removal of fibrinogen from plasma enhanced oxidation, while addition of fibrinogen restored inhibition. Copper 8-14 fibrinogen beta chain Homo sapiens 268-278 11583726-3 2001 Fibrinogen inhibited conjugated diene formation and peroxide formation assayed by the xylenol orange assay (absorbance+/-confidence interval: 0.155+/-0.007 with fibrinogen vs 0.255+/-0.014 without) and retarded copper mediated oxidation of apolipoproteins in low density lipoproteins, reducing the distance of electrophoretic migration by 5 mm. diene 32-37 fibrinogen beta chain Homo sapiens 0-10 11583726-3 2001 Fibrinogen inhibited conjugated diene formation and peroxide formation assayed by the xylenol orange assay (absorbance+/-confidence interval: 0.155+/-0.007 with fibrinogen vs 0.255+/-0.014 without) and retarded copper mediated oxidation of apolipoproteins in low density lipoproteins, reducing the distance of electrophoretic migration by 5 mm. Peroxides 52-60 fibrinogen beta chain Homo sapiens 0-10 11583726-3 2001 Fibrinogen inhibited conjugated diene formation and peroxide formation assayed by the xylenol orange assay (absorbance+/-confidence interval: 0.155+/-0.007 with fibrinogen vs 0.255+/-0.014 without) and retarded copper mediated oxidation of apolipoproteins in low density lipoproteins, reducing the distance of electrophoretic migration by 5 mm. xylenol orange 86-100 fibrinogen beta chain Homo sapiens 0-10 11583726-3 2001 Fibrinogen inhibited conjugated diene formation and peroxide formation assayed by the xylenol orange assay (absorbance+/-confidence interval: 0.155+/-0.007 with fibrinogen vs 0.255+/-0.014 without) and retarded copper mediated oxidation of apolipoproteins in low density lipoproteins, reducing the distance of electrophoretic migration by 5 mm. xylenol orange 86-100 fibrinogen beta chain Homo sapiens 161-171 11583726-3 2001 Fibrinogen inhibited conjugated diene formation and peroxide formation assayed by the xylenol orange assay (absorbance+/-confidence interval: 0.155+/-0.007 with fibrinogen vs 0.255+/-0.014 without) and retarded copper mediated oxidation of apolipoproteins in low density lipoproteins, reducing the distance of electrophoretic migration by 5 mm. Copper 211-217 fibrinogen beta chain Homo sapiens 0-10 11583726-4 2001 The effect of fibrinogen was not due to chelation of copper, since it provided protection when hydrogen peroxide was substituted for copper as an oxidizing agent. Copper 53-59 fibrinogen beta chain Homo sapiens 14-24 11583726-4 2001 The effect of fibrinogen was not due to chelation of copper, since it provided protection when hydrogen peroxide was substituted for copper as an oxidizing agent. Hydrogen Peroxide 95-112 fibrinogen beta chain Homo sapiens 14-24 11583726-4 2001 The effect of fibrinogen was not due to chelation of copper, since it provided protection when hydrogen peroxide was substituted for copper as an oxidizing agent. Copper 133-139 fibrinogen beta chain Homo sapiens 14-24 11583726-6 2001 Other studies have shown the fibrinogen to be more oxidizable than other major plasma proteins and to inhibit peroxide production. Peroxides 110-118 fibrinogen beta chain Homo sapiens 29-39 11562171-3 2001 Adherence assay to immobilized fibrinogen on polyethylene surfaces and peripheral venous catheters from patients showed that the fibrinogen binding ability of the mutant was reduced compared to its parental strain. Polyethylene 45-57 fibrinogen beta chain Homo sapiens 31-41 11416842-7 2001 Some plasma/matrix proteins (whole plasma, albumin, fibrinogen, and fibronectin) strongly interfered with the anti-microbicidal effects generated by neutrophil-polystyrene interaction. Polystyrenes 160-171 fibrinogen beta chain Homo sapiens 52-62 11562171-3 2001 Adherence assay to immobilized fibrinogen on polyethylene surfaces and peripheral venous catheters from patients showed that the fibrinogen binding ability of the mutant was reduced compared to its parental strain. Polyethylene 45-57 fibrinogen beta chain Homo sapiens 129-139 11668414-9 2001 Preliminary plasma protein adhesion measurements on immobilized HE derivatives with four different fluorescence-labeled plasma proteins showed a regioselective influence with serum albumin and fibrinogen. Heparin 64-66 fibrinogen beta chain Homo sapiens 193-203 11583737-3 2001 As part of an effort to characterize this phenomenon, a solid-phase reagent was prepared by adsorbing human fibrinogen to polystyrene-divinylbenzene microparticles. Amberlite XAD-2 resin 122-148 fibrinogen beta chain Homo sapiens 108-118 11778917-2 2001 For extracorporeal adsorption of fibrinogen, the pentapeptide gly-pro-arg-pro-lys was coupled to sepharose CL-4B3. Gly-Pro-Arg-Pro-Lys 62-81 fibrinogen beta chain Homo sapiens 33-43 11778917-2 2001 For extracorporeal adsorption of fibrinogen, the pentapeptide gly-pro-arg-pro-lys was coupled to sepharose CL-4B3. sepharose cl-4b3 97-113 fibrinogen beta chain Homo sapiens 33-43 11778917-3 2001 Adsorbers containing 135 ml of coupled sepharose CL-4B were used to eliminate fibrinogen from the plasma of 7 men and 3 women (48-75 years old). Sepharose CL 4B 39-54 fibrinogen beta chain Homo sapiens 78-88 11778917-15 2001 In conclusion, affinity chromatography using the pentapeptide gly-pro-arg-pro-lys is an effective, selective, and safe procedure to lower fibrinogen concentration in plasma. Gly-Pro-Arg-Pro-Lys 62-81 fibrinogen beta chain Homo sapiens 138-148 11520817-0 2001 Differential inhibition of adenosine diphosphate- versus thrombin receptor-activating peptide-stimulated platelet fibrinogen binding by abciximab due to different glycoprotein IIb/IIIa activation kinetics. Adenosine Diphosphate 27-48 fibrinogen beta chain Homo sapiens 114-124 11400130-0 2001 Modification of fibrinogen with poly(ethylene glycol) and its effects on fibrin clot characteristics. Polyethylene Glycols 32-52 fibrinogen beta chain Homo sapiens 16-26 11400130-2 2001 Poly(ethylene glycol) (PEG) offers potential solutions to these problems by providing a mechanism for increasing the number of crosslinks between adjacent fibrin monomer molecules or for covalently crosslinking Fgn to therapeutic agents. Polyethylene Glycols 0-21 fibrinogen beta chain Homo sapiens 211-214 11400130-2 2001 Poly(ethylene glycol) (PEG) offers potential solutions to these problems by providing a mechanism for increasing the number of crosslinks between adjacent fibrin monomer molecules or for covalently crosslinking Fgn to therapeutic agents. Polyethylene Glycols 23-26 fibrinogen beta chain Homo sapiens 211-214 11400130-4 2001 This study characterizes the clot characteristics of Fgn modified to varying degrees with monofunctional succinimidyl propionate PEG (5000 Da). N-succinimidyl propionate 105-128 fibrinogen beta chain Homo sapiens 53-56 11400130-4 2001 This study characterizes the clot characteristics of Fgn modified to varying degrees with monofunctional succinimidyl propionate PEG (5000 Da). Polyethylene Glycols 129-132 fibrinogen beta chain Homo sapiens 53-56 11400130-5 2001 The data indicate that, although thrombin clotting times are significantly altered, Fgn maintains 90% of its capacity to clot upon the addition of up to 5 PEG/Fgn. Polyethylene Glycols 155-158 fibrinogen beta chain Homo sapiens 84-87 11520817-3 2001 ADP-induced fibrinogen binding was completely inhibited by 10 microg/mL abciximab, 30 nM tirofiban, or 3 microg/mL eptifibatide, while fibrinogen binding induced by 100 microM TRAP was inhibited only by 50%. Adenosine Diphosphate 0-3 fibrinogen beta chain Homo sapiens 12-22 11520817-3 2001 ADP-induced fibrinogen binding was completely inhibited by 10 microg/mL abciximab, 30 nM tirofiban, or 3 microg/mL eptifibatide, while fibrinogen binding induced by 100 microM TRAP was inhibited only by 50%. Tirofiban 89-98 fibrinogen beta chain Homo sapiens 12-22 11520817-3 2001 ADP-induced fibrinogen binding was completely inhibited by 10 microg/mL abciximab, 30 nM tirofiban, or 3 microg/mL eptifibatide, while fibrinogen binding induced by 100 microM TRAP was inhibited only by 50%. Eptifibatide 115-127 fibrinogen beta chain Homo sapiens 12-22 11520817-4 2001 Interestingly, striking differences in fibrinogen binding kinetics in ADP- versus TRAP-stimulated platelets were observed. Adenosine Diphosphate 70-73 fibrinogen beta chain Homo sapiens 39-49 11520817-5 2001 ADP-induced fibrinogen binding was much slower than that of abciximab. Adenosine Diphosphate 0-3 fibrinogen beta chain Homo sapiens 12-22 11887299-2 2001 An open prospective and randomised pilot study was therefore undertaken in mild to moderate hypertensives to evaluate the effect of various antihypertensive drugs viz enalapril, felodipine and prazosin on the blood pressure and plasma fibrinogen levels. Enalapril 167-176 fibrinogen beta chain Homo sapiens 235-245 11887299-2 2001 An open prospective and randomised pilot study was therefore undertaken in mild to moderate hypertensives to evaluate the effect of various antihypertensive drugs viz enalapril, felodipine and prazosin on the blood pressure and plasma fibrinogen levels. Felodipine 178-188 fibrinogen beta chain Homo sapiens 235-245 11887299-2 2001 An open prospective and randomised pilot study was therefore undertaken in mild to moderate hypertensives to evaluate the effect of various antihypertensive drugs viz enalapril, felodipine and prazosin on the blood pressure and plasma fibrinogen levels. Prazosin 193-201 fibrinogen beta chain Homo sapiens 235-245 11509634-0 2001 Fibrinogen induces IL-8 synthesis in human neutrophils stimulated with formyl-methionyl-leucyl-phenylalanine or leukotriene B(4). Leukotriene B4 112-125 fibrinogen beta chain Homo sapiens 0-10 11562337-6 2001 Plasma homocysteine was positively correlated with fibrinogen (r=.34) and vWF (r=.23, each P<.001) only in Czechs, and with D-Dimer in both Czechs and Germans (r=.26 and.21, respectively). Homocysteine 7-19 fibrinogen beta chain Homo sapiens 51-61 11533267-10 2001 Dietary vitamin E and % energy from fat had positive effects, whereas plasma plasminogen activator inhibitor-1, fibrinogen, body weight and serum ferritin had negative effects on HDL and total to HDL cholesterol. Cholesterol 200-211 fibrinogen beta chain Homo sapiens 112-122 11562337-8 2001 In multivariate analyses, the association of homocysteine with D-Dimer remained statistically significant after adjustment for indicators of chronic inflammation and fibrinogen. Homocysteine 45-57 fibrinogen beta chain Homo sapiens 166-176 11468164-0 2001 The impaired polymerization of fibrinogen Longmont (Bbeta166Arg-->Cys) is not improved by removal of disulfide-linked dimers from a mixture of dimers and cysteine-linked monomers. bbeta166arg 52-63 fibrinogen beta chain Homo sapiens 31-41 11468164-0 2001 The impaired polymerization of fibrinogen Longmont (Bbeta166Arg-->Cys) is not improved by removal of disulfide-linked dimers from a mixture of dimers and cysteine-linked monomers. Cysteine 69-72 fibrinogen beta chain Homo sapiens 31-41 11468164-3 2001 The neo-Cys residues were always found to be disulfide-bridged to either an isolated Cys amino acid or to the corresponding Cys residue of another abnormal fibrinogen molecule, forming dimers. neo-cys 4-11 fibrinogen beta chain Homo sapiens 156-166 11468164-3 2001 The neo-Cys residues were always found to be disulfide-bridged to either an isolated Cys amino acid or to the corresponding Cys residue of another abnormal fibrinogen molecule, forming dimers. Disulfides 45-54 fibrinogen beta chain Homo sapiens 156-166 11468164-3 2001 The neo-Cys residues were always found to be disulfide-bridged to either an isolated Cys amino acid or to the corresponding Cys residue of another abnormal fibrinogen molecule, forming dimers. Cysteine 8-11 fibrinogen beta chain Homo sapiens 156-166 11468164-8 2001 Therefore, it is concluded that the substitution of Arg166-->Cys-Cys alters fibrinogen Longmont polymerization by disrupting interactions that are critical for normal lateral association of protofibrils. cysteinylcysteine 64-71 fibrinogen beta chain Homo sapiens 79-89 11672652-0 2001 Analysis of the response of planar polarization interferometer to molecular layer formation: fibrinogen adsorption on silicon nitride surface. silicon nitride 118-133 fibrinogen beta chain Homo sapiens 93-103 11672579-0 2001 Differences between neonates and adults in tissue-type-plasminogen activator (t-PA)-catalyzed plasminogen activation with various effectors and in carbohydrate sequences of fibrinogen chains. Carbohydrates 147-159 fibrinogen beta chain Homo sapiens 173-183 11672652-5 2001 Nonspecifical binding of fibrinogen to silicon nitride surface was studied as a model object for PPI testing. silicon nitride 39-54 fibrinogen beta chain Homo sapiens 25-35 11534261-4 2001 Fibrinogen is transformed into fibrin by thrombin, which may also activate protein C on phospholipid membranes when bound to TM. Phospholipids 88-100 fibrinogen beta chain Homo sapiens 0-10 11672579-9 2001 Mass spectrometric analysis of the N-glycans present on adult and fetal Bbeta- and gamma-fibrinogen chains showed the presence of a major monosialylated biantennary structure with lesser amounts of the disialylated form. n-glycans 35-44 fibrinogen beta chain Homo sapiens 89-99 11447076-7 2001 Higher fibrinogen levels were associated with increased epinephrine-induced aggregation (P=0.002) and a trend for ADP-induced aggregation (P=0.07). Adenosine Diphosphate 114-117 fibrinogen beta chain Homo sapiens 7-17 11806795-14 2001 The fibrinogen-lowering and lipid-modifying effects of bezafibrate were confirmed. Bezafibrate 55-66 fibrinogen beta chain Homo sapiens 4-14 11435303-3 2001 Polymerization of purified fibrinogen was strongly impaired in the presence of calcium or ethylenediaminetetraacetic acid (EDTA). Calcium 79-86 fibrinogen beta chain Homo sapiens 27-37 11435303-3 2001 Polymerization of purified fibrinogen was strongly impaired in the presence of calcium or ethylenediaminetetraacetic acid (EDTA). Edetic Acid 90-121 fibrinogen beta chain Homo sapiens 27-37 11435303-3 2001 Polymerization of purified fibrinogen was strongly impaired in the presence of calcium or ethylenediaminetetraacetic acid (EDTA). Edetic Acid 123-127 fibrinogen beta chain Homo sapiens 27-37 11435303-7 2001 Immunoblotting analysis with antibodies to human serum albumin indicated that albumin is bound to Aalpha 16 C. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) analysis of plasmin digests of fibrinogen Milano XII in the presence of calcium or EDTA showed both normal and novel D1 and D3 fragments. polyacrylamide 134-148 fibrinogen beta chain Homo sapiens 211-221 11447076-7 2001 Higher fibrinogen levels were associated with increased epinephrine-induced aggregation (P=0.002) and a trend for ADP-induced aggregation (P=0.07). Epinephrine 56-67 fibrinogen beta chain Homo sapiens 7-17 11887299-4 2001 It was observed that although all the three drugs effectively controlled blood pressure, only enalapril significantly reduced plasma fibrinogen levels. Enalapril 94-103 fibrinogen beta chain Homo sapiens 133-143 11887299-5 2001 Due to this additional effect, enalapril has potential to control two major cardiovascular risk factors--hypertension and high plasma fibrinogen levels--simultaneously. Enalapril 31-40 fibrinogen beta chain Homo sapiens 134-144 11693736-4 2001 We performed an in vitro study showing that the chemiluminescence (CL) emission produced by zymosan-activated polymorphonuclear leukocytes (PMNL) was directly related to the concentration of FB, fibrinopeptide A or FB-degradation products (FDP). Zymosan 92-99 fibrinogen beta chain Homo sapiens 191-193 11693736-4 2001 We performed an in vitro study showing that the chemiluminescence (CL) emission produced by zymosan-activated polymorphonuclear leukocytes (PMNL) was directly related to the concentration of FB, fibrinopeptide A or FB-degradation products (FDP). Zymosan 92-99 fibrinogen beta chain Homo sapiens 215-217 11396884-6 2001 However, stability was obtained after preparation on hydrophobic silicon or when albumin or fibrinogen was immobilized to silicon before the plasma incubations. Silicon 122-129 fibrinogen beta chain Homo sapiens 92-102 15348257-3 2001 In this study we demonstrated the adsorption of albumin, fibrinogen, fibronectin, basic fibroblast growth factor, heparin-binding epidermal growth factor-like growth factor and epidermal growth factor to poly(2-hydroxyethyl methacrylate) (pHEMA) and copolymer of 2-hydroxyethyl methacrylate (HEMA) and potassium salt of 3-sulfopropyl methacrylate (SPMAK). Polyhydroxyethyl Methacrylate 204-237 fibrinogen beta chain Homo sapiens 57-67 11422756-8 2001 In patients with NS the LPD regimen reduced proteinuria, ELF, albumin FSR and ASR, plasma fibrinogen levels, fibrinogen ASR, and increased serum ulbumin levels. prolinamide 24-27 fibrinogen beta chain Homo sapiens 90-100 11422756-8 2001 In patients with NS the LPD regimen reduced proteinuria, ELF, albumin FSR and ASR, plasma fibrinogen levels, fibrinogen ASR, and increased serum ulbumin levels. prolinamide 24-27 fibrinogen beta chain Homo sapiens 109-119 11375812-8 2001 This study shows that HES 450/0.7--0.8, HES 200/0.6--0.66, and HES 70/0.5--0.55 inhibit platelet function by reducing the availability of the functional receptor for fibrinogen on the platelet surface. Hydroxyethyl Starch Derivatives 22-25 fibrinogen beta chain Homo sapiens 166-176 11395043-7 2001 CRP, SAA and fibrinogen levels were markedly lower among CHD patients using cholesterol-lowering medication as compared to non-users. Cholesterol 76-87 fibrinogen beta chain Homo sapiens 13-23 11422017-6 2001 Reduced fibrinogen binding also led to a significant reduction of the aggregation response to ADP (down to 37% +/- 20) and collagen (down to 0%). Adenosine Diphosphate 94-97 fibrinogen beta chain Homo sapiens 8-18 11375248-6 2001 Roxifiban active form (XV459) demonstrated the highest potency in inhibiting 3H-XV459, 3H-DMP728, 125I-Echistatin, and 125I-Fibrinogen binding to human platelets as compared to the others. roxifiban 0-9 fibrinogen beta chain Homo sapiens 124-134 11375248-6 2001 Roxifiban active form (XV459) demonstrated the highest potency in inhibiting 3H-XV459, 3H-DMP728, 125I-Echistatin, and 125I-Fibrinogen binding to human platelets as compared to the others. XV 459 23-28 fibrinogen beta chain Homo sapiens 124-134 11477223-7 2001 Our results demonstrate that the strong lysine binding site in apo(a) KIV (10) is capable of mediating interactions with plasmin-modified fibrinogen in a lysine-dependent manner, and that this kringle can increase in vitro fibrin clot lysis time by approximately 43% at a concentration of 10 microM KIV (10). Lysine 40-46 fibrinogen beta chain Homo sapiens 138-148 11477223-7 2001 Our results demonstrate that the strong lysine binding site in apo(a) KIV (10) is capable of mediating interactions with plasmin-modified fibrinogen in a lysine-dependent manner, and that this kringle can increase in vitro fibrin clot lysis time by approximately 43% at a concentration of 10 microM KIV (10). Lysine 154-160 fibrinogen beta chain Homo sapiens 138-148 11477223-8 2001 The ability of the KIV (10) mutant derivatives to bind plasmin-modified fibrinogen correlated with their lysine binding capacity. Lysine 105-111 fibrinogen beta chain Homo sapiens 72-82 11477223-9 2001 Mutation of Trp (70) to Arg abolished binding to both lysine-Sepharose and plasmin-modified fibrinogen, while the Trp (70) -->Phe and Arg (35) -->Lys substitutions each resulted in decreased binding to these substrates. Tryptophan 12-15 fibrinogen beta chain Homo sapiens 92-102 11477223-9 2001 Mutation of Trp (70) to Arg abolished binding to both lysine-Sepharose and plasmin-modified fibrinogen, while the Trp (70) -->Phe and Arg (35) -->Lys substitutions each resulted in decreased binding to these substrates. Arginine 24-27 fibrinogen beta chain Homo sapiens 92-102 11477223-11 2001 Apo(a) KIV (7) contains a lysine- and proline-sensitive site capable of mediating binding to plasmin-modified fibrinogen, albeit with a lower apparent affinity than apo(a) KIV (10). Lysine 26-32 fibrinogen beta chain Homo sapiens 110-120 11477223-11 2001 Apo(a) KIV (7) contains a lysine- and proline-sensitive site capable of mediating binding to plasmin-modified fibrinogen, albeit with a lower apparent affinity than apo(a) KIV (10). Proline 38-45 fibrinogen beta chain Homo sapiens 110-120 11311131-4 2001 In addition, direct activation of protein kinase C with PMA resulted in tyrosine phosphorylation of Hic-5 only when platelets were fully aggregated with the exogenous addition of fibrinogen. Tyrosine 72-80 fibrinogen beta chain Homo sapiens 179-189 11311131-5 2001 Furthermore, PMA-induced Hic-5 tyrosine phosphorylation was also observed when platelets adhered to immobilized fibrinogen. Tetradecanoylphorbol Acetate 13-16 fibrinogen beta chain Homo sapiens 112-122 11311131-5 2001 Furthermore, PMA-induced Hic-5 tyrosine phosphorylation was also observed when platelets adhered to immobilized fibrinogen. Tyrosine 31-39 fibrinogen beta chain Homo sapiens 112-122 11313253-9 2001 Platelets from the thrombasthenic patient expressing [674R]GPIIb-IIIa were found to bind soluble fibrinogen in response to physiologic agonists or dithiothreitol treatment. Dithiothreitol 147-161 fibrinogen beta chain Homo sapiens 97-107 11313254-0 2001 Fibrinogen binding to the integrin alpha(IIb)beta(3) modulates store-mediated calcium entry in human platelets. Calcium 78-85 fibrinogen beta chain Homo sapiens 0-10 11313254-2 2001 Adding fibrinogen to washed platelet suspensions inhibited increases in cytosolic [Ca(++)] concentrations ([Ca(++)](i)) evoked by adenosine diphosphate (ADP) and thrombin in a concentration-dependent manner in the presence of external Ca(++) but not in the absence of external Ca(++) or in the presence of the nonselective cation channel blocker SKF96365, indicating selective inhibition of Ca(++) entry. Adenosine Diphosphate 130-151 fibrinogen beta chain Homo sapiens 7-17 11313254-2 2001 Adding fibrinogen to washed platelet suspensions inhibited increases in cytosolic [Ca(++)] concentrations ([Ca(++)](i)) evoked by adenosine diphosphate (ADP) and thrombin in a concentration-dependent manner in the presence of external Ca(++) but not in the absence of external Ca(++) or in the presence of the nonselective cation channel blocker SKF96365, indicating selective inhibition of Ca(++) entry. Adenosine Diphosphate 153-156 fibrinogen beta chain Homo sapiens 7-17 11313254-2 2001 Adding fibrinogen to washed platelet suspensions inhibited increases in cytosolic [Ca(++)] concentrations ([Ca(++)](i)) evoked by adenosine diphosphate (ADP) and thrombin in a concentration-dependent manner in the presence of external Ca(++) but not in the absence of external Ca(++) or in the presence of the nonselective cation channel blocker SKF96365, indicating selective inhibition of Ca(++) entry. 1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole 346-354 fibrinogen beta chain Homo sapiens 7-17 11313254-3 2001 Fibrinogen also inhibited store-mediated Ca(++) entry (SMCE) activated after Ca(++) store depletion using thapsigargin. Thapsigargin 106-118 fibrinogen beta chain Homo sapiens 0-10 11313254-7 2001 Fibrinogen inhibited actin polymerization evoked by ADP or thapsigargin in control cells and in cells loaded with the Ca(++) chelator dimethyl BAPTA. Adenosine Diphosphate 52-55 fibrinogen beta chain Homo sapiens 0-10 11313254-7 2001 Fibrinogen inhibited actin polymerization evoked by ADP or thapsigargin in control cells and in cells loaded with the Ca(++) chelator dimethyl BAPTA. Thapsigargin 59-71 fibrinogen beta chain Homo sapiens 0-10 11313254-7 2001 Fibrinogen inhibited actin polymerization evoked by ADP or thapsigargin in control cells and in cells loaded with the Ca(++) chelator dimethyl BAPTA. 5,5'-dimethyl-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetate 134-148 fibrinogen beta chain Homo sapiens 0-10 11352081-5 2001 RESULTS: Both dosages of tirofiban and abciximab reduced fibrinogen binding in response to 0.2 microM ADP comparably. Adenosine Diphosphate 102-105 fibrinogen beta chain Homo sapiens 57-67 11352081-6 2001 However, fibrinogen binding in response to 1.0 microM ADP or 25 microM TRAP was inhibited to a greater extent by the RESTORE dosage of tirofiban and abciximab than by the PRISM-PLUS dosage of tirofiban (P< 0.05). Adenosine Diphosphate 54-57 fibrinogen beta chain Homo sapiens 9-19 11447076-8 2001 The fibrinogen effect was genotype specific, however, in that the increase in platelet aggregability with higher fibrinogen was present for the Pl(A1/A1) genotype (P=0.0005 and P=0.03 for epinephrine- and ADP-induced aggregation, respectively) but not for the Pl(A2)-positive genotype (P>0.90). Epinephrine 188-199 fibrinogen beta chain Homo sapiens 4-14 11447076-8 2001 The fibrinogen effect was genotype specific, however, in that the increase in platelet aggregability with higher fibrinogen was present for the Pl(A1/A1) genotype (P=0.0005 and P=0.03 for epinephrine- and ADP-induced aggregation, respectively) but not for the Pl(A2)-positive genotype (P>0.90). Adenosine Diphosphate 205-208 fibrinogen beta chain Homo sapiens 4-14 11370269-5 2001 These bodies stained with the periodic acid-Schiff (PAS) technique; the PAS-positive material was partly diastase digestible and on immunostaining marked for fibrinogen but not for alpha 1-antitrypsin. Aminosalicylic Acid 72-75 fibrinogen beta chain Homo sapiens 158-168 11278633-8 2001 These results demonstrate that the alpha(M)(Lys(245)-Arg(261)) segment, a site of the major sequence and structure difference among alpha(M)I-, alpha(X)I-, and alpha(L)I-domains, is responsible for recognition of a small segment of fibrinogen, gammaThr(383)-Gly(395), by serving as ligand binding site. Lysine 44-47 fibrinogen beta chain Homo sapiens 232-242 11278633-8 2001 These results demonstrate that the alpha(M)(Lys(245)-Arg(261)) segment, a site of the major sequence and structure difference among alpha(M)I-, alpha(X)I-, and alpha(L)I-domains, is responsible for recognition of a small segment of fibrinogen, gammaThr(383)-Gly(395), by serving as ligand binding site. Arginine 53-56 fibrinogen beta chain Homo sapiens 232-242 11278633-8 2001 These results demonstrate that the alpha(M)(Lys(245)-Arg(261)) segment, a site of the major sequence and structure difference among alpha(M)I-, alpha(X)I-, and alpha(L)I-domains, is responsible for recognition of a small segment of fibrinogen, gammaThr(383)-Gly(395), by serving as ligand binding site. Glycine 258-261 fibrinogen beta chain Homo sapiens 232-242 11334580-0 2001 [Effect on plasma fibrinogen of hypercholesterolaemia treatment with pravastatin]. Pravastatin 69-80 fibrinogen beta chain Homo sapiens 18-28 11334580-1 2001 OBJECTIVE: To determine whether hypercholesterolaemia treatment with pravastatin causes modifications in plasma fibrinogen. Pravastatin 69-80 fibrinogen beta chain Homo sapiens 112-122 11334580-15 2001 CONCLUSIONS: We found an 11.9% drop of plasma fibrinogen in patients with hypercholesterolaemia treated with pravastatin. Pravastatin 109-120 fibrinogen beta chain Homo sapiens 46-56 11401083-0 2001 Thrombin converts singlet oxygen (1O2)-oxidized fibrinogen into a soluble t-PA cofactor. Singlet Oxygen 18-32 fibrinogen beta chain Homo sapiens 48-58 11367862-10 2001 The ciprofibrate was suspended after the 8th week for a 4 weeks period and the triglyceride and the fibrinogen levels increased whereas the HDL cholesterol level decreased significantly. ciprofibrate 4-16 fibrinogen beta chain Homo sapiens 100-110 11312916-0 2001 Discovery of an orally active non-peptide fibrinogen receptor antagonist based on the hydantoin scaffold. Hydantoins 86-95 fibrinogen beta chain Homo sapiens 42-52 11312916-2 2001 The binding of fibrinogen to the fibrinogen receptor depends on an Arg-Gly-Asp-Ser (RGDS) tetrapeptide recognition motif. Arginine 67-70 fibrinogen beta chain Homo sapiens 15-25 11312916-2 2001 The binding of fibrinogen to the fibrinogen receptor depends on an Arg-Gly-Asp-Ser (RGDS) tetrapeptide recognition motif. Arginine 67-70 fibrinogen beta chain Homo sapiens 33-43 11312916-2 2001 The binding of fibrinogen to the fibrinogen receptor depends on an Arg-Gly-Asp-Ser (RGDS) tetrapeptide recognition motif. Gly-Asp-Ser 71-82 fibrinogen beta chain Homo sapiens 15-25 11312916-2 2001 The binding of fibrinogen to the fibrinogen receptor depends on an Arg-Gly-Asp-Ser (RGDS) tetrapeptide recognition motif. Gly-Asp-Ser 71-82 fibrinogen beta chain Homo sapiens 33-43 11401083-0 2001 Thrombin converts singlet oxygen (1O2)-oxidized fibrinogen into a soluble t-PA cofactor. CHEBI:63768 34-37 fibrinogen beta chain Homo sapiens 48-58 11401083-3 2001 1O2-oxidized fibrinogen or oxidized fibrin monomer has previously been shown to be unpolymerizable, and methionine to methionine sulfoxide-oxidized fibrinogen occurs in circulating blood. CHEBI:63768 0-3 fibrinogen beta chain Homo sapiens 13-23 11254918-2 2001 In this randomized placebo-controlled crossover study, we evaluated whether changes in fibrinogen levels were different between atorvastatin and other statin-treated patients. Atorvastatin 128-140 fibrinogen beta chain Homo sapiens 87-97 11401083-3 2001 1O2-oxidized fibrinogen or oxidized fibrin monomer has previously been shown to be unpolymerizable, and methionine to methionine sulfoxide-oxidized fibrinogen occurs in circulating blood. Methionine 104-114 fibrinogen beta chain Homo sapiens 148-158 11401083-3 2001 1O2-oxidized fibrinogen or oxidized fibrin monomer has previously been shown to be unpolymerizable, and methionine to methionine sulfoxide-oxidized fibrinogen occurs in circulating blood. methionine sulfoxide 118-138 fibrinogen beta chain Homo sapiens 148-158 11282030-5 2001 The affinity of this receptor for its ligands vitronectin, fibronectin and fibrinogen can be modulated by the divalent cations magnesium, calcium and manganese. Magnesium 127-136 fibrinogen beta chain Homo sapiens 75-85 11287891-7 2001 Quantitative integrated backscatter of LASEC correlated directly with left atrial fibrinogen level (r = 0.78, P =.013) but not with markers of thrombin generation (thrombin-antithrombin III) or activity (fibrinopeptide A). lasec 39-44 fibrinogen beta chain Homo sapiens 82-92 11287891-9 2001 However, the intensity of LASEC assessed by quantitative integrated backscatter correlates with both right and left atrial intact fibrinogen level, a systemic marker of coagulation. lasec 26-31 fibrinogen beta chain Homo sapiens 130-140 11282030-5 2001 The affinity of this receptor for its ligands vitronectin, fibronectin and fibrinogen can be modulated by the divalent cations magnesium, calcium and manganese. Calcium 138-145 fibrinogen beta chain Homo sapiens 75-85 11282030-5 2001 The affinity of this receptor for its ligands vitronectin, fibronectin and fibrinogen can be modulated by the divalent cations magnesium, calcium and manganese. Manganese 150-159 fibrinogen beta chain Homo sapiens 75-85 11254338-0 2001 Thermally Induced Transient Activity Changes of Plasmin Adsorbed onto Bare and Fibrinogen-Modified Graphite and Glassy Carbon Surfaces. Graphite 99-107 fibrinogen beta chain Homo sapiens 79-89 11254338-0 2001 Thermally Induced Transient Activity Changes of Plasmin Adsorbed onto Bare and Fibrinogen-Modified Graphite and Glassy Carbon Surfaces. Carbon 119-125 fibrinogen beta chain Homo sapiens 79-89 11254338-3 2001 The amount of fibrinogen adsorbed at graphite was determined by ELISA. Graphite 37-45 fibrinogen beta chain Homo sapiens 14-24 11341508-1 2001 SR121566 is a new synthetic agent which inhibits the binding of fibrinogen to activated platelets, and platelet aggregation. SR 121566 0-8 fibrinogen beta chain Homo sapiens 64-74 11260565-6 2001 RESULTS: We found that high-dose methotrexate administration adversely affected both the coagulation system (prolonged prothrombin time and activated partial thromboplastin time and decreased fibrinogen levels) and coagulation inhibitors (decreased protein C, protein S, antithrombin III) on day 1 after chemotherapy compared to the baseline values. Methotrexate 33-45 fibrinogen beta chain Homo sapiens 192-202 11283497-6 2001 RESULTS: The patients with APV in the acute phase compared with the patients with Meniere"s disease in the acute phase exhibited increased plasma levels of fibrinogen (mean, 338.3 +/- 135.9 SD vs 271.3 +/- 69.8 SD mg/dL, P = 0.05), increased plasma levels of D-dimer (mean, 320 +/- 207.8 SD vs 226.7 +/- 138.7 SD NG/mL), enhanced plasma levels of lipoprotein(a) (41.4 +/- 38.6 SD vs 16 +/- 18.2 SD mg/dL, F = 5.67, P = 0.02), high leukocyte count (9.1 +/- 2.7 SD vs 6.5 +/- 1.3 SD x 10(3)/microL; F = 8.42, P < 0.006), and low serum folate concentration (5.3 +/- 1.8 SD vs 7.1 +/- 2.7 NG/mg; F = 4.34, P = 0.04). Folic Acid 536-542 fibrinogen beta chain Homo sapiens 156-166 11322175-1 2001 The effects of 2-chloro-3-(4-hexylphenyl)-amino-1,4-naphthoquinone (NQ304), an antithrombotic agent, on aggregation, binding of fibrinogen to glycoprotein IIb/IIIa and intracellular signals were investigated using human platelets. NQ304 68-73 fibrinogen beta chain Homo sapiens 128-138 11322175-3 2001 NQ304 significantly inhibited fluorescein isothiocyanate-conjugated fibrinogen binding to human platelet surface glycoprotein IIb/IIIa receptor by 75%, but failed to inhibit the fibrinogen binding to purified glycoprotein IIb/IIIa receptor. NQ304 0-5 fibrinogen beta chain Homo sapiens 68-78 11322175-3 2001 NQ304 significantly inhibited fluorescein isothiocyanate-conjugated fibrinogen binding to human platelet surface glycoprotein IIb/IIIa receptor by 75%, but failed to inhibit the fibrinogen binding to purified glycoprotein IIb/IIIa receptor. Fluorescein-5-isothiocyanate 30-56 fibrinogen beta chain Homo sapiens 68-78 11341513-3 2001 Similar studies using citrate anticoagulated blood showed that this was due to fibrinogen and not fibrin. Citric Acid 22-29 fibrinogen beta chain Homo sapiens 79-89 12577350-4 2001 In the heparin group, level of PT and APTT prolonged, FIB decreased, t-PA activity elevated and PAI activity lowered, and APC unchanged. Heparin 7-14 fibrinogen beta chain Homo sapiens 54-57 11333182-4 2001 In our study, 1 and 5 mM nickel in the presence of fibrinogen induced platelet aggregation (independently of protein kinase C activation) and secretion. Nickel 25-31 fibrinogen beta chain Homo sapiens 51-61 11171108-4 2001 Anhydrothrombin retained affinity for various natural substrates of thrombin, including fibrinogen, factor VIII, factor XIII and protein C. In addition, these proteins were bound to anhydrothrombin-agarose in a reversible manner. Sepharose 198-205 fibrinogen beta chain Homo sapiens 88-98 11159525-3 2001 The ensuing unpaired cysteine at Aalpha 442 generated fibrinogen-albumin complexes of different molecular weights. Cysteine 21-29 fibrinogen beta chain Homo sapiens 54-64 11257465-6 2001 We found that in a dose-dependent manner fibrinogen inhibited superoxide generation (pyrogallol and xanthine-xanthine oxidase reactions), ferrous ion oxidation and hydroxyl radical dependent degradation (of deoxyribose). Superoxides 62-72 fibrinogen beta chain Homo sapiens 41-51 11257465-6 2001 We found that in a dose-dependent manner fibrinogen inhibited superoxide generation (pyrogallol and xanthine-xanthine oxidase reactions), ferrous ion oxidation and hydroxyl radical dependent degradation (of deoxyribose). Pyrogallol 85-95 fibrinogen beta chain Homo sapiens 41-51 11257465-6 2001 We found that in a dose-dependent manner fibrinogen inhibited superoxide generation (pyrogallol and xanthine-xanthine oxidase reactions), ferrous ion oxidation and hydroxyl radical dependent degradation (of deoxyribose). ammonium ferrous sulfate 138-149 fibrinogen beta chain Homo sapiens 41-51 11257465-6 2001 We found that in a dose-dependent manner fibrinogen inhibited superoxide generation (pyrogallol and xanthine-xanthine oxidase reactions), ferrous ion oxidation and hydroxyl radical dependent degradation (of deoxyribose). Hydroxyl Radical 164-180 fibrinogen beta chain Homo sapiens 41-51 11257465-6 2001 We found that in a dose-dependent manner fibrinogen inhibited superoxide generation (pyrogallol and xanthine-xanthine oxidase reactions), ferrous ion oxidation and hydroxyl radical dependent degradation (of deoxyribose). Deoxyribose 207-218 fibrinogen beta chain Homo sapiens 41-51 11257465-7 2001 Fibrinogen also inhibited LDL oxidation (copper and azo compound-induced), hydrogen peroxide oxidation and chemiluminescence produced by polymorphonuclear leukocytes. Copper 41-47 fibrinogen beta chain Homo sapiens 0-10 11257465-7 2001 Fibrinogen also inhibited LDL oxidation (copper and azo compound-induced), hydrogen peroxide oxidation and chemiluminescence produced by polymorphonuclear leukocytes. Azo Compounds 52-64 fibrinogen beta chain Homo sapiens 0-10 11257465-7 2001 Fibrinogen also inhibited LDL oxidation (copper and azo compound-induced), hydrogen peroxide oxidation and chemiluminescence produced by polymorphonuclear leukocytes. Hydrogen Peroxide 75-92 fibrinogen beta chain Homo sapiens 0-10 11241131-4 2001 Heparin"s effect on fibrinogen binding to platelets was measured with a radioligand-binding assay. Heparin 0-7 fibrinogen beta chain Homo sapiens 20-30 11241131-8 2001 Low concentrations of unfractionated porcine mucosal heparin (2-5 U/mL) significantly increased fibrinogen I 125 binding to activated platelets, whereas higher doses did not. Heparin 53-60 fibrinogen beta chain Homo sapiens 96-106 11241131-9 2001 Heparin-mediated platelet aggregation was completely blocked by GRGDS peptide (5 mmol/L), a competitive inhibitor of fibrinogen binding, and was blocked by EDTA (2 mmol/L), which dissociates the functional integrin complex. Heparin 0-7 fibrinogen beta chain Homo sapiens 117-127 11215845-6 2001 The effects of four HMG-CoA reductase inhibitors (atorvastatin, lovastatin, simvastatin, pravastatin) on fibrinogen have been evaluated. Lovastatin 64-74 fibrinogen beta chain Homo sapiens 105-115 11165973-0 2001 Fibrinogen response with simvastatin versus atorvastatin in familial hypercholesterolemia. Simvastatin 25-36 fibrinogen beta chain Homo sapiens 0-10 11165973-1 2001 The clinical and biochemical determinants of the fibrinogen response to simvastatin or atorvastatin therapy were assessed in 130 patients with severe polygenic or familial hypercholesterolemia treated in a randomized open-trial format design. Simvastatin 72-83 fibrinogen beta chain Homo sapiens 49-59 11165973-2 2001 Hyperfibrinogenemia was associated with atorvastatin, baseline fibrinogen, and initial concentration and change in concentration of apolipoprotein B or low-density lipoprotein cholesterol. Atorvastatin 40-52 fibrinogen beta chain Homo sapiens 5-15 11215845-6 2001 The effects of four HMG-CoA reductase inhibitors (atorvastatin, lovastatin, simvastatin, pravastatin) on fibrinogen have been evaluated. Atorvastatin 50-62 fibrinogen beta chain Homo sapiens 105-115 11215845-6 2001 The effects of four HMG-CoA reductase inhibitors (atorvastatin, lovastatin, simvastatin, pravastatin) on fibrinogen have been evaluated. Simvastatin 76-87 fibrinogen beta chain Homo sapiens 105-115 11215845-6 2001 The effects of four HMG-CoA reductase inhibitors (atorvastatin, lovastatin, simvastatin, pravastatin) on fibrinogen have been evaluated. Pravastatin 89-100 fibrinogen beta chain Homo sapiens 105-115 11215845-7 2001 Atorvastatin has been shown to induce significant increases in fibrinogen (22% increase; p <0.05) by using the immunonephelometric method. Atorvastatin 0-12 fibrinogen beta chain Homo sapiens 63-73 11215845-8 2001 This method also demonstrated that lovastatin use was associated with a 24.4% increase (p < 0.0001) in plasma fibrinogen concentration. Lovastatin 35-45 fibrinogen beta chain Homo sapiens 113-123 11215845-9 2001 Simvastatin has been shown in multiple studies using the Clauss method to have a neutral effect on fibrinogen. Simvastatin 0-11 fibrinogen beta chain Homo sapiens 99-109 11215845-10 2001 The majority of studies have revealed significant decreases (7-19%) in fibrinogen following treatment with pravastatin. Pravastatin 107-118 fibrinogen beta chain Homo sapiens 71-81 11205440-5 2001 Two proteins, namely bovine serum albumine (BSA) and fibrinogen, were physically entrapped in these hydrogels by mixing with the polymer solutions before gel formation. Polymers 129-136 fibrinogen beta chain Homo sapiens 28-63 11156862-4 2001 Tamoxifen was associated with reductions of 26% in median C-reactive protein, 22% in median fibrinogen, and 9% in cholesterol (all P:<0.01 compared with placebo). Tamoxifen 0-9 fibrinogen beta chain Homo sapiens 92-102 11156862-7 2001 The effect on fibrinogen was larger in women with higher baseline cholesterol. Cholesterol 66-77 fibrinogen beta chain Homo sapiens 14-24 11225135-4 2001 Fibrinogen levels were associated with age (r = 0.873), hypertension (p = 0.032), body mass index (r = 0.898), triglyceride level (r = 0.9396), cholesterol level (r = 0.99), glycosylated hemoglobin (r = 0.99) and urine albumin excretion rate (r = 0.930) in diabetics, in a significant manner. Triglycerides 111-123 fibrinogen beta chain Homo sapiens 0-10 11225135-4 2001 Fibrinogen levels were associated with age (r = 0.873), hypertension (p = 0.032), body mass index (r = 0.898), triglyceride level (r = 0.9396), cholesterol level (r = 0.99), glycosylated hemoglobin (r = 0.99) and urine albumin excretion rate (r = 0.930) in diabetics, in a significant manner. Cholesterol 144-155 fibrinogen beta chain Homo sapiens 0-10 11460466-3 2001 Fibrinogen is comprised of two sets of three polypeptide chains termed A alpha, B beta, and gamma, that are joined by disulfide bridging within the N-terminal E domain. Disulfides 118-127 fibrinogen beta chain Homo sapiens 0-10 11229418-0 2001 Homocysteine, fibrinogen, and lipoprotein(a) levels are simultaneously reduced in patients with chronic renal failure treated with folic acid, pyridoxine, and cyanocobalamin. Folic Acid 131-141 fibrinogen beta chain Homo sapiens 14-24 11229418-0 2001 Homocysteine, fibrinogen, and lipoprotein(a) levels are simultaneously reduced in patients with chronic renal failure treated with folic acid, pyridoxine, and cyanocobalamin. Pyridoxine 143-153 fibrinogen beta chain Homo sapiens 14-24 11229418-0 2001 Homocysteine, fibrinogen, and lipoprotein(a) levels are simultaneously reduced in patients with chronic renal failure treated with folic acid, pyridoxine, and cyanocobalamin. Vitamin B 12 159-173 fibrinogen beta chain Homo sapiens 14-24 11229418-4 2001 A positive correlation between decreasing homocysteine and fibrinogen levels was also noted. Homocysteine 42-54 fibrinogen beta chain Homo sapiens 59-69 11246553-6 2001 In blood from subjects given aspirin for 5 days, abciximab-induced inhibition of the capacity to bind fibrinogen in response to 1 microM ADP was greater when the daily dose had been 325 mg compared with 81 mg (% inhibition: no aspirin 53 +/- 6; 81 mg daily 62 +/- 5; 325 mg daily 69 +/- 6). Aspirin 29-36 fibrinogen beta chain Homo sapiens 102-112 11246553-6 2001 In blood from subjects given aspirin for 5 days, abciximab-induced inhibition of the capacity to bind fibrinogen in response to 1 microM ADP was greater when the daily dose had been 325 mg compared with 81 mg (% inhibition: no aspirin 53 +/- 6; 81 mg daily 62 +/- 5; 325 mg daily 69 +/- 6). Adenosine Diphosphate 137-140 fibrinogen beta chain Homo sapiens 102-112 11342210-1 2001 The fibrinogen molecule consists of two sets of Aalpha, Bbeta, and gamma chains assembled into a bilateral disulfide linked (Aalpha, Bbeta, gamma)2 structure. Disulfides 107-116 fibrinogen beta chain Homo sapiens 4-14 14728038-6 2001 Vitamin therapy with folate, pyridoxine (vitamin B(6)), and cyanocobalamin (vitamin B(12)) reduces blood levels of homocyst(e)ine, improves endothelial function, reduces levels of fibrinogen and lipoprotein(a), improves thrombolysis, and in uncontrolled clinical observation, leads to regression of carotid plaque. Folic Acid 21-27 fibrinogen beta chain Homo sapiens 180-190 14728038-6 2001 Vitamin therapy with folate, pyridoxine (vitamin B(6)), and cyanocobalamin (vitamin B(12)) reduces blood levels of homocyst(e)ine, improves endothelial function, reduces levels of fibrinogen and lipoprotein(a), improves thrombolysis, and in uncontrolled clinical observation, leads to regression of carotid plaque. Pyridoxine 29-39 fibrinogen beta chain Homo sapiens 180-190 14728038-6 2001 Vitamin therapy with folate, pyridoxine (vitamin B(6)), and cyanocobalamin (vitamin B(12)) reduces blood levels of homocyst(e)ine, improves endothelial function, reduces levels of fibrinogen and lipoprotein(a), improves thrombolysis, and in uncontrolled clinical observation, leads to regression of carotid plaque. Vitamin B 12 60-74 fibrinogen beta chain Homo sapiens 180-190 14728038-6 2001 Vitamin therapy with folate, pyridoxine (vitamin B(6)), and cyanocobalamin (vitamin B(12)) reduces blood levels of homocyst(e)ine, improves endothelial function, reduces levels of fibrinogen and lipoprotein(a), improves thrombolysis, and in uncontrolled clinical observation, leads to regression of carotid plaque. Niacinamide 76-85 fibrinogen beta chain Homo sapiens 180-190 11460477-2 2001 We have characterized the lysine residues in fibrinogen to which PAI-2 is crosslinked by tissue transglutaminase and factor XIIIa. Lysine 26-32 fibrinogen beta chain Homo sapiens 45-55 11460488-0 2001 Fibrinogen alpha C domains contain cryptic plasminogen and tPA binding sites. Tetradecanoylphorbol Acetate 59-62 fibrinogen beta chain Homo sapiens 0-10 11460488-1 2001 Surface plasmon resonance and ELISA experiments revealed that recombinant fibrinogen alpha C fragment (residues A alpha 221-610) corresponding to the alpha C domain binds tPA and plasminogen with high affinity. Tetradecanoylphorbol Acetate 171-174 fibrinogen beta chain Homo sapiens 74-84 11460501-2 2001 Replacement of W215 with Ala reduces fibrinogen and PAR4 cleavage 500-fold and 280-fold, respectively. Alanine 25-28 fibrinogen beta chain Homo sapiens 37-47 11460503-1 2001 Platelet adhesion to low-density coated fibrinogen induces greater protein tyrosine phosphorylation of SYK and FAK than adhesion to high-density coated fibrinogen, and leads to activation of integrin alpha IIb beta 3 on the luminal side of adherent platelets. Tyrosine 75-83 fibrinogen beta chain Homo sapiens 40-50 11460506-8 2001 Studies with recombinant systems, using deletion and substitution mutants, indicate that initial chain assembly depends on hydrophobic interactions present in the C-terminal half of the coil-coil domains and that inter- and intra-disulfide bonds that stabilize fibrinogen are needed to complete chain assembly. Disulfides 230-239 fibrinogen beta chain Homo sapiens 261-271 11460506-18 2001 In HepG2 cells, a feedback mechanism exists and extracellular sterols specifically downregulate expression of the three fibrinogen genes. Sterols 62-69 fibrinogen beta chain Homo sapiens 120-130 11460508-10 2001 Several drugs are known to influence fibrinogen levels, the most studied of which are platelet aggregation inhibiting drugs, such as ticlopidine, and the lipid lowering fibric acid derivatives (fibrates). Ticlopidine 133-144 fibrinogen beta chain Homo sapiens 37-47 11460508-10 2001 Several drugs are known to influence fibrinogen levels, the most studied of which are platelet aggregation inhibiting drugs, such as ticlopidine, and the lipid lowering fibric acid derivatives (fibrates). fibric acid 169-180 fibrinogen beta chain Homo sapiens 37-47 11460508-13 2001 In the Bezalip study, fibrinogen levels decreased in patients treated with bezafibrate, but this had no clear effect on the risk of cardiovascular disease. Bezafibrate 7-14 fibrinogen beta chain Homo sapiens 22-32 11460508-13 2001 In the Bezalip study, fibrinogen levels decreased in patients treated with bezafibrate, but this had no clear effect on the risk of cardiovascular disease. Bezafibrate 75-86 fibrinogen beta chain Homo sapiens 22-32 11460511-0 2001 Modified clotting properties of fibrinogen in the presence of acetylsalicylic acid in a purified system. Aspirin 62-82 fibrinogen beta chain Homo sapiens 32-42 11460511-1 2001 To assess how treatment with acetylsalicylic acid (ASA) alters the fibrin network structure, clotting was initiated in purified fibrinogen incubated with ASA by adding thrombin. Aspirin 29-49 fibrinogen beta chain Homo sapiens 128-138 11460523-0 2001 Effect of moderate alcohol consumption on fibrinogen levels in healthy volunteers is discordant with effects on C-reactive protein. Alcohols 19-26 fibrinogen beta chain Homo sapiens 42-52 11460523-1 2001 In a diet-controlled, crossover trial with 10 middle-aged men and 9 postmenopausal women, baseline concentrations of fibrinogen influenced the magnitude of decrease of fibrinogen after moderate alcohol consumption. Alcohols 194-201 fibrinogen beta chain Homo sapiens 117-127 11460523-1 2001 In a diet-controlled, crossover trial with 10 middle-aged men and 9 postmenopausal women, baseline concentrations of fibrinogen influenced the magnitude of decrease of fibrinogen after moderate alcohol consumption. Alcohols 194-201 fibrinogen beta chain Homo sapiens 168-178 11460526-1 2001 Fibrinogen, a 340-kDa plasma protein, is composed of two identical molecular halves each consisting of three non-identical A alpha-, B beta- and gamma-chain subunits held together by multiple disulfide bonds. Disulfides 192-201 fibrinogen beta chain Homo sapiens 0-10 11460528-2 2001 Reverse phase chromatography, isoelectric focussing, electrospray mass spectrometry, and tryptic peptide mass mapping have shown that chains with heterozygous mutations of gamma 284 Gly-->Arg, B beta 316 Asp-->Tyr and gamma 371 Thr-->Ile are absent from plasma fibrinogen. Glycine 182-185 fibrinogen beta chain Homo sapiens 270-280 11145946-11 2001 The superiority of abciximab over aspirin in accelerating fibrinolysis of forming and preformed PRCs is related to its ability to modulate the interactions of fibrinogen and fibrin with platelets. Aspirin 34-41 fibrinogen beta chain Homo sapiens 159-169 11777392-0 2001 Fibrinogen-conjugated albumin polymers and their interaction with platelets under flow conditions. Polymers 30-38 fibrinogen beta chain Homo sapiens 0-10 11777392-2 2001 Fibrinogen could be conjugated on the surface of an albumin polymer using N-succinimidyl 3-(2-pyridyldithio)propionate (SPDP). N-succinimidyl 3-(2-pyridyldithio)propionate 74-118 fibrinogen beta chain Homo sapiens 0-10 11777392-2 2001 Fibrinogen could be conjugated on the surface of an albumin polymer using N-succinimidyl 3-(2-pyridyldithio)propionate (SPDP). N-succinimidyl 3-(2-pyridyldithio)propionate 120-124 fibrinogen beta chain Homo sapiens 0-10 11190901-7 2001 Incubation with adenosine diphosphate in the control group resulted in minor increases of platelet activation, which was significant only for platelet-bound fibrinogen (16.6 +/- 11.3 vs. 42.5 +/- 22.1; p = 0.02). Adenosine Diphosphate 16-37 fibrinogen beta chain Homo sapiens 157-167 11779428-2 2001 METHODS: Using 125I-labeled human fibrinogen (Fg), specific Fg binding to human platelets induced by HI117 and SJ9A4 was measured. Iodine-125 15-19 fibrinogen beta chain Homo sapiens 34-44 11564911-10 2001 During recovery, while the increase in haematocrit post-exercise returned to the baseline level in both control and alcohol trials, plasma viscosity and plasma fibrinogen remained significantly high during recovery in the alcohol trial compared with control condition. Alcohols 222-229 fibrinogen beta chain Homo sapiens 160-170 11564911-11 2001 It is concluded that exercise induces significant changes in the main determinants of blood rheology and the consumption of alcohol after physical exercise delays the normal return of plasma viscosity, plasma fibrinogen to the resting baseline levels during recovery. Alcohols 124-131 fibrinogen beta chain Homo sapiens 209-219 11268711-7 2001 A small non-significant increase of plasma fibrinogen was found (3.04 g/l vs. 3.14 g/l) after 24 weeks of atorvastatin administration. Atorvastatin 106-118 fibrinogen beta chain Homo sapiens 43-53 12188016-6 2001 Fibrinogen was directly related to age, body mass index (BMI) and female gender and inversely to alcohol and moderate-heavy physical activity practice. Alcohols 97-104 fibrinogen beta chain Homo sapiens 0-10 11408744-0 2001 Fibrinogen kaiserslautern III: a new case of congenital dysfibrinogenemia with aalpha 16 arg-->cys substitution. Arginine 89-92 fibrinogen beta chain Homo sapiens 0-10 11408744-0 2001 Fibrinogen kaiserslautern III: a new case of congenital dysfibrinogenemia with aalpha 16 arg-->cys substitution. Cysteine 98-101 fibrinogen beta chain Homo sapiens 0-10 11334184-3 2001 In the present study, polystyrene surfaces adsorbed with both Fg and vWF induced up to three times greater procoagulant activity than surfaces adsorbed with Fg or vWF only. Polystyrenes 22-33 fibrinogen beta chain Homo sapiens 62-64 11787523-0 2001 Inhibition of monocyte adhesion and fibrinogen adsorption on glow discharge plasma deposited tetraethylene glycol dimethyl ether. tetraglyme 93-128 fibrinogen beta chain Homo sapiens 36-46 11787523-6 2001 Fibrinogen adsorption to the tetraglyme surface was measured with 125I-labeled fibrinogen and ToF-SIMS. Iodine-125 66-70 fibrinogen beta chain Homo sapiens 0-10 11787523-6 2001 Fibrinogen adsorption to the tetraglyme surface was measured with 125I-labeled fibrinogen and ToF-SIMS. Iodine-125 66-70 fibrinogen beta chain Homo sapiens 79-89 11922480-1 2001 Adsorption of human serum albumin (HSA), human gamma-globulins (gammaG), and human fibrinogen (Fb) onto the surface of poly(styrene/alpha-t-butoxy-omega-vinylbenzyl-polyglycidol) microspheres (P(S/PGL)) with controlled fraction of polyglycidol in the interfacial layer was investigated. poly 119-123 fibrinogen beta chain Homo sapiens 83-93 11922480-1 2001 Adsorption of human serum albumin (HSA), human gamma-globulins (gammaG), and human fibrinogen (Fb) onto the surface of poly(styrene/alpha-t-butoxy-omega-vinylbenzyl-polyglycidol) microspheres (P(S/PGL)) with controlled fraction of polyglycidol in the interfacial layer was investigated. poly 119-123 fibrinogen beta chain Homo sapiens 95-97 11922480-1 2001 Adsorption of human serum albumin (HSA), human gamma-globulins (gammaG), and human fibrinogen (Fb) onto the surface of poly(styrene/alpha-t-butoxy-omega-vinylbenzyl-polyglycidol) microspheres (P(S/PGL)) with controlled fraction of polyglycidol in the interfacial layer was investigated. Styrene 124-131 fibrinogen beta chain Homo sapiens 83-93 11922480-1 2001 Adsorption of human serum albumin (HSA), human gamma-globulins (gammaG), and human fibrinogen (Fb) onto the surface of poly(styrene/alpha-t-butoxy-omega-vinylbenzyl-polyglycidol) microspheres (P(S/PGL)) with controlled fraction of polyglycidol in the interfacial layer was investigated. Styrene 124-131 fibrinogen beta chain Homo sapiens 95-97 11494443-2 2001 MATERIAL AND METHOD: Sulodexide was given to 15 patients which were examined for blood fibrinogen, foot tissues saturation with oxygen, microbic contamination of the wound tissue. glucuronyl glucosamine glycan sulfate 21-31 fibrinogen beta chain Homo sapiens 87-97 11204586-7 2001 The effect of simvastatin on fibrinogen (p = 0.005) was more pronounced than the effects of atorvastatin (p = 0.48 n.s.) Simvastatin 14-25 fibrinogen beta chain Homo sapiens 29-39 11123898-0 2000 Conversion of fibrinogen to fibrin: mechanism of exposure of tPA- and plasminogen-binding sites. Tetradecanoylphorbol Acetate 61-64 fibrinogen beta chain Homo sapiens 14-24 11374856-4 2000 In a head-to-head comparison study, niacin 2,000 mg/day increased HDL-C more than gemfibrozil 1,200 mg/day, and decreased the total cholesterol-to-HDL-C ratio, lipoprotein (a) (Lp[a]), and fibrinogen levels significantly more. Niacin 36-42 fibrinogen beta chain Homo sapiens 189-199 11262912-5 2000 Alcohol decreases the fibrinogen level and increases tPA, inhibits platelet aggregation and reduces factor VIIc. Alcohols 0-7 fibrinogen beta chain Homo sapiens 22-32 11112110-7 2000 Fibrinogen was positively correlated with RDI (r = 0.24, p = 0.007), duration of the longest apnea (r = 0.18, p = 0.049), and negatively correlated with several oxygen indices including average minimal oxygen saturation (r = -0.41, p < 0.001). Oxygen 161-167 fibrinogen beta chain Homo sapiens 0-10 11112110-7 2000 Fibrinogen was positively correlated with RDI (r = 0.24, p = 0.007), duration of the longest apnea (r = 0.18, p = 0.049), and negatively correlated with several oxygen indices including average minimal oxygen saturation (r = -0.41, p < 0.001). Oxygen 202-208 fibrinogen beta chain Homo sapiens 0-10 11112110-9 2000 Multiple linear regression identified minimal mean oxygen saturation and sex as independent predictors of fibrinogen level. Oxygen 51-57 fibrinogen beta chain Homo sapiens 106-116 11117616-5 2000 There was a trend toward lower adjusted beta-cryptoxanthin concentrations with increasing level of fibrinogen (p value test for trend = 0.01), but other carotenoids were not related. Beta-Cryptoxanthin 40-58 fibrinogen beta chain Homo sapiens 99-109 11090059-4 2000 Binding studies using the 165 amino acid form of VEGF immobilized on Sepharose beads and soluble iodine 125 ((125)I)-labeled fibrinogen demonstrated saturable and specific binding. Iodine 97-103 fibrinogen beta chain Homo sapiens 125-135 11460470-4 2001 The neo-Cys residues were found to be disulfide-bridged to either an isolated Cys amino acid or to the corresponding Cys residue of another abnormal fibrinogen molecule, forming dimers. neo-cys 4-11 fibrinogen beta chain Homo sapiens 149-159 11460470-4 2001 The neo-Cys residues were found to be disulfide-bridged to either an isolated Cys amino acid or to the corresponding Cys residue of another abnormal fibrinogen molecule, forming dimers. Disulfides 38-47 fibrinogen beta chain Homo sapiens 149-159 11460470-4 2001 The neo-Cys residues were found to be disulfide-bridged to either an isolated Cys amino acid or to the corresponding Cys residue of another abnormal fibrinogen molecule, forming dimers. cys amino acid 78-92 fibrinogen beta chain Homo sapiens 149-159 11460470-4 2001 The neo-Cys residues were found to be disulfide-bridged to either an isolated Cys amino acid or to the corresponding Cys residue of another abnormal fibrinogen molecule, forming dimers. Cysteine 8-11 fibrinogen beta chain Homo sapiens 149-159 11460472-2 2001 The plateau concentration of alpha-profibrin (20% of initial fibrinogen) appearing in reactions indicated, however, that the second FPA is released four times faster than the first. alpha-profibrin 29-44 fibrinogen beta chain Homo sapiens 61-71 11063957-7 2000 Creatinine clearance was significantly and inversely correlated with levels of plasma fibrinogen (Spearman"s rho = -0.26, P <0.001), D-dimer (rho = -0.33, P <0.001), and prothrombin fragment 1 + 2 (rho = -0.20, P <0.001). Creatinine 0-10 fibrinogen beta chain Homo sapiens 86-96 11153893-0 2000 Effect of magnesium on fibrin formation from lower molecular weight (LMW) fibrinogen. Magnesium 10-19 fibrinogen beta chain Homo sapiens 74-84 11153893-3 2000 We have recently observed that the values of fibrinogen measured by thrombin clotting time (the method of Clauss) were consistently lower in EDTA plasma than those obtained with citrated plasma. Edetic Acid 141-145 fibrinogen beta chain Homo sapiens 45-55 11063957-8 2000 Levels of plasma fibrinogen (P = 0.009) and D-dimer (P = 0.003) were correlated with renal function independent of age, blood pressure, duration of hypertension, triglyceride level, urinary protein excretion, and erythrocyte sedimentation rate. Triglycerides 162-174 fibrinogen beta chain Homo sapiens 17-27 11063957-10 2000 CONCLUSIONS: Increased plasma levels of fibrinogen, D-dimer, and prothrombin fragment 1 + 2 are present in hypertensive patients with mildly decreased creatinine clearance, suggesting that the coagulation system is activated in these patients. Creatinine 151-161 fibrinogen beta chain Homo sapiens 40-50 11131105-6 2000 Age, obesity, systolic blood pressure and triglycerides were significantly associated with diabetes status in both sexes, fibrinogen in men only and high density lipoprotein cholesterol negatively in women. Triglycerides 42-55 fibrinogen beta chain Homo sapiens 122-132 11131105-7 2000 CONCLUSIONS: The prevalence of Type 2 diabetes mellitus was very high especially in older subjects, and fibrinogen was associated with increasing glucose intolerance in men but not in women. Glucose 146-153 fibrinogen beta chain Homo sapiens 104-114 11108903-9 2000 Compared to platelet fibrinogen binding of unfixed resting (4.5+/-2.1%) and ADP-stimulated (56.7+/-22.6%) samples, formaldehyde or paraformaldehyde fixation had no significant influence on resting samples, but mildly increased fibrinogen binding in stimulated samples. Adenosine Diphosphate 76-79 fibrinogen beta chain Homo sapiens 21-31 11050236-4 2000 Interaction of soluble or immobilized fibrinogen with normal human or murine platelets triggers rapid tyrosine phosphorylation of SLP-76. Tyrosine 102-110 fibrinogen beta chain Homo sapiens 38-48 11108903-11 2000 Thus, formaldehyde and paraformaldehyde have mild but complex influences on platelet P-selectin expression and fibrinogen binding measurements. Formaldehyde 6-18 fibrinogen beta chain Homo sapiens 111-121 11108903-11 2000 Thus, formaldehyde and paraformaldehyde have mild but complex influences on platelet P-selectin expression and fibrinogen binding measurements. paraform 23-39 fibrinogen beta chain Homo sapiens 111-121 11127863-8 2000 The anti-alphavbeta3 antibody, LM609, blocked adhesion of endothelial cells to fibrinogen. lm609 31-36 fibrinogen beta chain Homo sapiens 79-89 11050236-5 2000 Moreover, platelet adhesion to fibrinogen stimulates actin rearrangements, filopodial and lamellipodial extension, and localization of tyrosine phosphorylated proteins to the cell periphery. Tyrosine 135-143 fibrinogen beta chain Homo sapiens 31-41 11209669-5 2000 We postulate that low vitamin C levels in winter could be associated raised plasma fibrinogen and plasminogen activator-1 (PAI-1) concentrations and therefore with increased cardiovascular risk. Ascorbic Acid 22-31 fibrinogen beta chain Homo sapiens 83-93 11015340-6 2000 With the immunoprecipitation method, there were significant linear trends across fibrinogen tertiles (P:<0.001) for age, body mass index, smoking, diabetes mellitus, total cholesterol, HDL cholesterol, and triglycerides in men and women. Cholesterol 175-186 fibrinogen beta chain Homo sapiens 81-91 11015340-6 2000 With the immunoprecipitation method, there were significant linear trends across fibrinogen tertiles (P:<0.001) for age, body mass index, smoking, diabetes mellitus, total cholesterol, HDL cholesterol, and triglycerides in men and women. Cholesterol 192-203 fibrinogen beta chain Homo sapiens 81-91 11015340-6 2000 With the immunoprecipitation method, there were significant linear trends across fibrinogen tertiles (P:<0.001) for age, body mass index, smoking, diabetes mellitus, total cholesterol, HDL cholesterol, and triglycerides in men and women. Triglycerides 209-222 fibrinogen beta chain Homo sapiens 81-91 11068987-8 2000 These findings support that PBs are secretory fibrinogen accumulated in cystic ER and that such intracellular accumulation possibly reflects a defective transport of fibrinogen. Lead 28-31 fibrinogen beta chain Homo sapiens 46-56 11011154-6 2000 The binding of fibrinogen to immobilized alpha(5)beta(1) was selectively supported by Mn(2+). alpha(5)beta(1) 41-56 fibrinogen beta chain Homo sapiens 15-25 11011154-6 2000 The binding of fibrinogen to immobilized alpha(5)beta(1) was selectively supported by Mn(2+). Manganese(2+) 86-92 fibrinogen beta chain Homo sapiens 15-25 11011154-7 2000 Fibrinogen bound to purified alpha(5)beta(1) in a time-dependent, specific, and saturable manner in the presence of Mn(2+), and the binding was blocked completely by Arg-Gly-Asp (RGD)-containing peptides and by anti-alpha(5) and anti-alpha(5)beta(1) monoclonal antibodies. Arginine 166-169 fibrinogen beta chain Homo sapiens 0-10 11011154-7 2000 Fibrinogen bound to purified alpha(5)beta(1) in a time-dependent, specific, and saturable manner in the presence of Mn(2+), and the binding was blocked completely by Arg-Gly-Asp (RGD)-containing peptides and by anti-alpha(5) and anti-alpha(5)beta(1) monoclonal antibodies. Glycine 170-173 fibrinogen beta chain Homo sapiens 0-10 11011154-7 2000 Fibrinogen bound to purified alpha(5)beta(1) in a time-dependent, specific, and saturable manner in the presence of Mn(2+), and the binding was blocked completely by Arg-Gly-Asp (RGD)-containing peptides and by anti-alpha(5) and anti-alpha(5)beta(1) monoclonal antibodies. Aspartic Acid 174-177 fibrinogen beta chain Homo sapiens 0-10 10864922-2 2000 In our studies, the ligation of Fg to ICAM-1 on tumor necrosis factor-alpha-stimulated endothelial cells resulted in the tyrosine phosphorylation of Src homology domain 2 (SH2)-containing phosphatase-2 (SHP-2). Tyrosine 121-129 fibrinogen beta chain Homo sapiens 32-34 11012904-9 2000 In a logistic regression model, fibrinogen was independently associated with microalbuminuria (P = 0.047), along with hypertension, female gender, waist circumference, and fasting blood glucose, while CRP was not independently related to microalbuminuria in this model (P = 0.26). Glucose 186-193 fibrinogen beta chain Homo sapiens 32-42 11057851-7 2000 Elevated D-dimer and fibrinogen levels were independently associated with the presence of decreased creatinine clearance. Creatinine 100-110 fibrinogen beta chain Homo sapiens 21-31 11057851-8 2000 Log fibrinogen, log F1+2, and log D-dimer were inversely correlated with creatinine clearance. Creatinine 73-83 fibrinogen beta chain Homo sapiens 4-14 11938810-4 2000 Ligustrazine also showed obvious effect in lowering blood level of fibrinogen in Group C. CONCLUSION: Treatment of acute ICVD with large dose of ligustrazine is good in improving clinical effect and hemorrheology, and without side effect basically. tetramethylpyrazine 0-12 fibrinogen beta chain Homo sapiens 67-77 11938810-4 2000 Ligustrazine also showed obvious effect in lowering blood level of fibrinogen in Group C. CONCLUSION: Treatment of acute ICVD with large dose of ligustrazine is good in improving clinical effect and hemorrheology, and without side effect basically. tetramethylpyrazine 145-157 fibrinogen beta chain Homo sapiens 67-77 10984503-1 2000 We report the study of the dynamics of the unbinding process under a force load f of adsorbed proteins (fibrinogen) on a solid surface (hydrophilic silica) by means of atomic force microscopy spectroscopy. Silicon Dioxide 148-154 fibrinogen beta chain Homo sapiens 104-114 10961871-6 2000 Cell attachment to fibrinogen caused the enhanced tyrosine phosphorylation of Pyk2 and the initial tyrosine phosphorylation of Syk, which was also inhibited by pretreatment with anti-beta2 integrin antibody. Tyrosine 50-58 fibrinogen beta chain Homo sapiens 19-29 10975860-0 2000 A SAF binding site in the promoter region of human gamma-fibrinogen gene functions as an IL-6 response element. Safflower Oil 2-5 fibrinogen beta chain Homo sapiens 57-67 10880071-4 2000 We report imaging isolated fibrinogen molecules adsorbed on National Heart Lung and Blood Institute (NHLBI) reference materials polydimethylsiloxane and low-density polyethylene in situ using phase imaging AFM. baysilon 128-148 fibrinogen beta chain Homo sapiens 27-37 10880071-4 2000 We report imaging isolated fibrinogen molecules adsorbed on National Heart Lung and Blood Institute (NHLBI) reference materials polydimethylsiloxane and low-density polyethylene in situ using phase imaging AFM. Polyethylene 153-177 fibrinogen beta chain Homo sapiens 27-37 11026518-8 2000 In the 101 diabetic subjects, only changes in plasma triglyceride correlated with the changes in fibrinogen concentration. Triglycerides 53-65 fibrinogen beta chain Homo sapiens 97-107 10961871-6 2000 Cell attachment to fibrinogen caused the enhanced tyrosine phosphorylation of Pyk2 and the initial tyrosine phosphorylation of Syk, which was also inhibited by pretreatment with anti-beta2 integrin antibody. Tyrosine 99-107 fibrinogen beta chain Homo sapiens 19-29 10999796-0 2000 Increased fibrinogen production in type 2 diabetic patients without detectable vascular complications: correlation with plasma glucagon concentrations. Glucagon 127-135 fibrinogen beta chain Homo sapiens 10-20 11016870-4 2000 It was shown that resveratrol significantly inhibited adhesion of both thrombin- and ADP-activated platelets to Fg. Resveratrol 18-29 fibrinogen beta chain Homo sapiens 112-114 11016870-7 2000 The inhibition of platelet adhesion of Fg caused by Trolox was lower than by resveratrol and at higher concentration (1 mM) reached maximum 12%. 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid 52-58 fibrinogen beta chain Homo sapiens 39-41 11016870-7 2000 The inhibition of platelet adhesion of Fg caused by Trolox was lower than by resveratrol and at higher concentration (1 mM) reached maximum 12%. Resveratrol 77-88 fibrinogen beta chain Homo sapiens 39-41 11016870-9 2000 We conclude that changed adhesion of blood platelets to Fg in the presence of resveratrol and Trolox, but not selenium may be the result of different antioxidative activities of tested compounds. Resveratrol 78-89 fibrinogen beta chain Homo sapiens 56-58 11016870-9 2000 We conclude that changed adhesion of blood platelets to Fg in the presence of resveratrol and Trolox, but not selenium may be the result of different antioxidative activities of tested compounds. 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid 94-100 fibrinogen beta chain Homo sapiens 56-58 10926473-6 2000 Protein rejection studies indicate that the adsorption of fibrinogen is inhibited by copolymer preadsorption. copolymer 85-94 fibrinogen beta chain Homo sapiens 58-68 10816585-1 2000 In this study, we identified lysine residues in the fibrinogen Aalpha chain that serve as substrates during transglutaminase (TG)-mediated cross-linking of plasminogen activator inhibitor 2 (PAI-2). Lysine 29-35 fibrinogen beta chain Homo sapiens 52-62 10816585-3 2000 A 30-residue peptide containing Lys-303 specifically competed with fibrinogen for cross-linking to alpha(2)-AP but not for cross-linking to PAI-2. Lysine 32-35 fibrinogen beta chain Homo sapiens 67-77 10911375-9 2000 In vitro studies of the proband"s purified fibrinogen revealed markedly abnormal thrombin-catalyzed polymerization and delayed fibrin clot lysis by tPA-activated plasmin. Tetradecanoylphorbol Acetate 148-151 fibrinogen beta chain Homo sapiens 43-53 10910944-1 2000 We report on a family with a history of venous thromboembolism associated with fibrinogen Paris V (fibrinogen Aalpha-Arg554-->Cys). Cysteine 129-132 fibrinogen beta chain Homo sapiens 79-89 10910944-1 2000 We report on a family with a history of venous thromboembolism associated with fibrinogen Paris V (fibrinogen Aalpha-Arg554-->Cys). Cysteine 129-132 fibrinogen beta chain Homo sapiens 99-109 10903502-8 2000 The MEK-1 inhibitor PD 98059 blocked ERK-1/2 phosphorylation, and treatment of endothelial cells with PD 98059 resulted in apoptosis even upon Fg : ICAM-1 ligation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 20-28 fibrinogen beta chain Homo sapiens 143-145 10903502-8 2000 The MEK-1 inhibitor PD 98059 blocked ERK-1/2 phosphorylation, and treatment of endothelial cells with PD 98059 resulted in apoptosis even upon Fg : ICAM-1 ligation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 102-110 fibrinogen beta chain Homo sapiens 143-145 10887149-6 2000 Early truncation of the A alpha chain appears to result in defective assembly or secretion of fibrinogen, probably due to the removal of the C-terminal disulfide ring residues that are critically required for the formation of a stable 3-chained half molecule. Disulfides 152-161 fibrinogen beta chain Homo sapiens 94-104 10946093-2 2000 Fibrinogen Caracas V is a thrombotic dysfibrinogenemia with an Aalpha 532 Ser-->Cys mutation characterized by a tight fibrin network formed of thin fibers responsible for a less porous clot than a normal one. Serine 74-77 fibrinogen beta chain Homo sapiens 0-10 10946093-2 2000 Fibrinogen Caracas V is a thrombotic dysfibrinogenemia with an Aalpha 532 Ser-->Cys mutation characterized by a tight fibrin network formed of thin fibers responsible for a less porous clot than a normal one. Cysteine 83-86 fibrinogen beta chain Homo sapiens 0-10 10946093-5 2000 Correction of clot structure anomaly, by addition of dextran 40 to fibrinogen before clotting, induces an improvement in fibrin degradation that was attributed to an increase in porosity. Dextrans 53-60 fibrinogen beta chain Homo sapiens 67-77 10946093-7 2000 Furthermore, this abnormal fibrinogen binds more albumin than does normal fibrinogen, a phenomenon attributed to the mutation of serine in Aalpha-532 by cysteine. Serine 129-135 fibrinogen beta chain Homo sapiens 27-37 10946093-7 2000 Furthermore, this abnormal fibrinogen binds more albumin than does normal fibrinogen, a phenomenon attributed to the mutation of serine in Aalpha-532 by cysteine. Serine 129-135 fibrinogen beta chain Homo sapiens 74-84 10946093-7 2000 Furthermore, this abnormal fibrinogen binds more albumin than does normal fibrinogen, a phenomenon attributed to the mutation of serine in Aalpha-532 by cysteine. Cysteine 153-161 fibrinogen beta chain Homo sapiens 27-37 10946093-7 2000 Furthermore, this abnormal fibrinogen binds more albumin than does normal fibrinogen, a phenomenon attributed to the mutation of serine in Aalpha-532 by cysteine. Cysteine 153-161 fibrinogen beta chain Homo sapiens 74-84 10891092-5 2000 Replacement of W215 with Ala almost obliterates Na(+) binding, reduces the level of fibrinogen cleavage 500-fold, but decreases the levels of protein C activation and PAR-1 cleavage only 3- and 25-fold, respectively. Alanine 25-28 fibrinogen beta chain Homo sapiens 84-94 10884507-2 2000 TA-993 and MB3 concentration-dependently inhibited fibrinogen binding to the ADP-stimulated platelets as well as inhibiting platelet aggregation. TA 993 0-6 fibrinogen beta chain Homo sapiens 51-61 10884507-2 2000 TA-993 and MB3 concentration-dependently inhibited fibrinogen binding to the ADP-stimulated platelets as well as inhibiting platelet aggregation. Adenosine Diphosphate 77-80 fibrinogen beta chain Homo sapiens 51-61 10884507-4 2000 Aggregation of ADP-treated fixed platelets caused by the addition of fibrinogen was inhibited by RGDS but not by TA-993 and MB3. Adenosine Diphosphate 15-18 fibrinogen beta chain Homo sapiens 69-79 10933570-9 2000 The reduction, however, of fibrinogen, plasminogen activator inhibitor-1, and thrombomodulin was significantly greater in the irbesartan than in the atenolol group. Irbesartan 126-136 fibrinogen beta chain Homo sapiens 27-37 10880389-0 2000 Fibrinogen brescia: hepatic endoplasmic reticulum storage and hypofibrinogenemia because of a gamma284 Gly-->Arg mutation. gamma284 94-102 fibrinogen beta chain Homo sapiens 0-10 10880389-0 2000 Fibrinogen brescia: hepatic endoplasmic reticulum storage and hypofibrinogenemia because of a gamma284 Gly-->Arg mutation. Glycine 103-106 fibrinogen beta chain Homo sapiens 0-10 10880389-0 2000 Fibrinogen brescia: hepatic endoplasmic reticulum storage and hypofibrinogenemia because of a gamma284 Gly-->Arg mutation. Arginine 109-112 fibrinogen beta chain Homo sapiens 0-10 10997789-4 2000 We find that binding of fibrinogen on monocytes activated with adenosine diphosphate (ADP) was reduced to 66.0+/-8.3% (mean +/- SD) in the presence of anti-CD11b antibodies (12.5 microg/ml; P < or = 0.02) and to 54.5+/-4.9% in the presence of anti-CD18 antibodies (20 microg/ml; P < or = 0.01), respectively. Adenosine Diphosphate 63-84 fibrinogen beta chain Homo sapiens 24-34 10997789-4 2000 We find that binding of fibrinogen on monocytes activated with adenosine diphosphate (ADP) was reduced to 66.0+/-8.3% (mean +/- SD) in the presence of anti-CD11b antibodies (12.5 microg/ml; P < or = 0.02) and to 54.5+/-4.9% in the presence of anti-CD18 antibodies (20 microg/ml; P < or = 0.01), respectively. Adenosine Diphosphate 86-89 fibrinogen beta chain Homo sapiens 24-34 11054082-10 2000 On the contrary, the Pl(A2) allele is associated with a platelet functional deficiency, specifically linked to the activation of the fibrinogen receptor by thromboxane A(2). thromboxane a 156-169 fibrinogen beta chain Homo sapiens 133-143 10850929-4 2000 Fixation of biological tissue with glutaraldehyde or genipin significantly increased its hydrophilicity and surface tension and reduced its mol ratio of adsorbed fibrinogen to adsorbed albumin as well as the amount of adhered platelet. Glutaral 35-49 fibrinogen beta chain Homo sapiens 162-172 10981184-5 2000 Plasma fibrinogen concentration was associated with age, body weight, body mass index, white blood cell count and CPITN score, and inversely associated with serum HDL cholesterol in male nonsmokers. Cholesterol 167-178 fibrinogen beta chain Homo sapiens 7-17 10954339-6 2000 In particular, pravastatin at a dosage of 20 mg/ day significantly reduced only fibrinogen levels, while at a dosage of 40 mg/day significantly reduced factor VII, fibrinogen, prothrombin fragments 1 and 2, thrombin-antithrombin complexes, tissue plasminogen activator antigen (tPA:Ag) before venous occlusion (b.o. Pravastatin 15-26 fibrinogen beta chain Homo sapiens 80-90 10954339-6 2000 In particular, pravastatin at a dosage of 20 mg/ day significantly reduced only fibrinogen levels, while at a dosage of 40 mg/day significantly reduced factor VII, fibrinogen, prothrombin fragments 1 and 2, thrombin-antithrombin complexes, tissue plasminogen activator antigen (tPA:Ag) before venous occlusion (b.o. Pravastatin 15-26 fibrinogen beta chain Homo sapiens 164-174 11155036-7 2000 NNKY5-5-induced platelet aggregates exhibited both PAC-1 binding and fibrinogen, but vWF was not found in them. nnky5-5 0-7 fibrinogen beta chain Homo sapiens 69-79 10873614-5 2000 HepG2 cells overexpressing fibrinogen chains had increased 3-hydroxy-3-methylglutaryl coenzyme A reductase mRNA levels, enhanced cholesterol production but normal levels of triglyceride and phospholipid synthesis and of sterol response binding proteins. Cholesterol 129-140 fibrinogen beta chain Homo sapiens 27-37 10928468-8 2000 Further in silico analysis of the crystal structure of fibrinogen fragment D-D indicated that Bbeta262-269 (FGRKWDPY) is predominantly alpha-helical and located on the surface of the molecule adjacent to a bend imposed in the beta chain at residue 260, which is near the junction between the rigid coiled-coil domain and the globular C-terminus. bbeta262 94-102 fibrinogen beta chain Homo sapiens 55-65 10873614-5 2000 HepG2 cells overexpressing fibrinogen chains had increased 3-hydroxy-3-methylglutaryl coenzyme A reductase mRNA levels, enhanced cholesterol production but normal levels of triglyceride and phospholipid synthesis and of sterol response binding proteins. Triglycerides 173-185 fibrinogen beta chain Homo sapiens 27-37 10873614-5 2000 HepG2 cells overexpressing fibrinogen chains had increased 3-hydroxy-3-methylglutaryl coenzyme A reductase mRNA levels, enhanced cholesterol production but normal levels of triglyceride and phospholipid synthesis and of sterol response binding proteins. Phospholipids 190-202 fibrinogen beta chain Homo sapiens 27-37 10873614-5 2000 HepG2 cells overexpressing fibrinogen chains had increased 3-hydroxy-3-methylglutaryl coenzyme A reductase mRNA levels, enhanced cholesterol production but normal levels of triglyceride and phospholipid synthesis and of sterol response binding proteins. Sterols 134-140 fibrinogen beta chain Homo sapiens 27-37 10845911-6 2000 The binding was specific because unlabeled HKa, Mac-1-specific antibody, and fibrinogen can inhibit the binding of biotin-HKa to Mac-1 transfected cells. Biotin 115-121 fibrinogen beta chain Homo sapiens 77-87 10845892-8 2000 Treatment of transduced megakaryocytes with a combination of agonists including epinephrine and the thrombin receptor-activating peptide induced the alphaIIbbeta(3) complex to form an activated conformation capable of binding fibrinogen as measured by PAC-1 antibody binding. Epinephrine 80-91 fibrinogen beta chain Homo sapiens 226-236 10928468-9 2000 A synthetic peptide corresponding to Bbeta261-272 competitively inhibited the binding of D73H to the Bbeta chain of denatured intact fibrinogen and reduced and denatured Bbeta chain in Western blots, experimentally proving the validity of these predictive algorithms. bbeta261 37-45 fibrinogen beta chain Homo sapiens 133-143 10748039-2 2000 We synthesized a variant, recombinant fibrinogen modeled after the heterozygous dysfibrinogen Vlissingen/Frankfurt IV, a deletion of two residues, gammaAsn-319 and gammaAsp-320, located within the high affinity calcium-binding pocket. Calcium 211-218 fibrinogen beta chain Homo sapiens 38-48 10899349-6 2000 Reviparin reduced the fibrinogen molecules deposited on injured vessels at high shear rates (252+/-80 molecules x 10(12)/cm2 for reviparine (200 U/kg/hour) vs. 624+/-70 x 10(12)/cm for unfractionated heparin (200 U/kg/hour) (p<0.05). reviparin 0-9 fibrinogen beta chain Homo sapiens 22-32 10899349-7 2000 At low shear rates, fibrinogen deposition was also significantly reduced by reviparin (130+/-15 molecules x 10(12)/cm2) compared to unfractionated heparin (192+/-40 x 10(12)/cm2 at 200 U/kg/hour; p<0.05). reviparin 76-85 fibrinogen beta chain Homo sapiens 20-30 10748039-6 2000 Plasmin cleavage of this fibrinogen was not changed by the presence of calcium or Gly-Pro-Arg-Pro, indicating that both the calcium-binding site and the "a" polymerization site were non-functional. Calcium 124-131 fibrinogen beta chain Homo sapiens 25-35 10843900-8 2000 This increase in intracellular free calcium concentration induced by MAb 1.9 was found to be dependent on the binding of fibrinogen to activated GPIIb/IIIa integrins, suggesting that MAb 1.9 causes Ca(2+) flux through the fibrinogen receptor complex. Calcium 36-43 fibrinogen beta chain Homo sapiens 121-131 10843900-8 2000 This increase in intracellular free calcium concentration induced by MAb 1.9 was found to be dependent on the binding of fibrinogen to activated GPIIb/IIIa integrins, suggesting that MAb 1.9 causes Ca(2+) flux through the fibrinogen receptor complex. Calcium 36-43 fibrinogen beta chain Homo sapiens 222-232 10847423-0 2000 The effect of alcohol ingestion on the exercise-induced changes in fibrin and fibrinogen degradation products in man. Alcohols 14-21 fibrinogen beta chain Homo sapiens 78-88 10814588-4 2000 Beads coated with condensed films of copolymers that contain short PEO segments and elicit appreciable inflammation absorb appreciable quantities of plasma proteins, including fibrinogen, from aqueous solution. copolymers 37-47 fibrinogen beta chain Homo sapiens 176-186 10814588-8 2000 In this regard, the ability of the copolymers to influence fibrinogen-mediated adhesive events may be particularly important. copolymers 35-45 fibrinogen beta chain Homo sapiens 59-69 10827966-1 2000 The kinetics of adhesion of platelets to fibrinogen (Fg) immobilized on polystyrene latex beads (Fg-beads) was determined in suspensions undergoing Couette flow at well-defined homogeneous shear rates. Polystyrenes 72-83 fibrinogen beta chain Homo sapiens 41-51 10827966-1 2000 The kinetics of adhesion of platelets to fibrinogen (Fg) immobilized on polystyrene latex beads (Fg-beads) was determined in suspensions undergoing Couette flow at well-defined homogeneous shear rates. Polystyrenes 72-83 fibrinogen beta chain Homo sapiens 53-55 10827966-5 2000 The apparent efficiency of platelet adhesion to Fg-beads readily correlated with the proportion of platelets "quantally" activated by doses of ADP, i.e., only ADP-activated platelets appeared to adhere to Fg-beads, with a maximal adhesion efficiency of 6-10% at shear rates of 100-300 s(-1), decreasing with increasing shear rates up to 2000 s(-1). Adenosine Diphosphate 143-146 fibrinogen beta chain Homo sapiens 48-50 10827966-5 2000 The apparent efficiency of platelet adhesion to Fg-beads readily correlated with the proportion of platelets "quantally" activated by doses of ADP, i.e., only ADP-activated platelets appeared to adhere to Fg-beads, with a maximal adhesion efficiency of 6-10% at shear rates of 100-300 s(-1), decreasing with increasing shear rates up to 2000 s(-1). Adenosine Diphosphate 159-162 fibrinogen beta chain Homo sapiens 205-207 10848898-12 2000 Serum-opsonized Sephadex particles stimulated a potent increase of the release of ECP up to 12%-14% in the presence of plasma fibronectin and, in particular, fibrinogen. sephadex 16-24 fibrinogen beta chain Homo sapiens 158-168 10847423-6 2000 Although plasma fibrinogen level showed significant decrease post-exercise when subjects ingested alcohol, this difference was small and its biological significance is questionable. Alcohols 98-105 fibrinogen beta chain Homo sapiens 16-26 10877197-0 2000 Ad libitum intake of low-fat diets rich in either starchy foods or sucrose: effects on blood lipids, factor VII coagulant activity, and fibrinogen. starchy foods 50-63 fibrinogen beta chain Homo sapiens 87-146 10877212-1 2000 Epidemiological studies suggest that the plasma fibrinogen concentration is the main determinant of plasma viscosity (PV), but the concentration of other macromolecules (eg, immunoglobulins) and low-density lipoprotein (LDL) cholesterol and triglycerides are also correlated with PV. Cholesterol 225-236 fibrinogen beta chain Homo sapiens 48-58 10877197-0 2000 Ad libitum intake of low-fat diets rich in either starchy foods or sucrose: effects on blood lipids, factor VII coagulant activity, and fibrinogen. Sucrose 67-74 fibrinogen beta chain Homo sapiens 87-146 10877212-1 2000 Epidemiological studies suggest that the plasma fibrinogen concentration is the main determinant of plasma viscosity (PV), but the concentration of other macromolecules (eg, immunoglobulins) and low-density lipoprotein (LDL) cholesterol and triglycerides are also correlated with PV. Triglycerides 241-254 fibrinogen beta chain Homo sapiens 48-58 10877212-8 2000 Second, hypertriglyceridemic samples (n = 7) were pumped through the fibrinogen-depleting column, which reduced the fibrinogen concentration from 4.29 +/- 0.79 to 1.62 +/- 0.69 g/L (P < .001) and PV from 1.42 +/- 0.06 to 1.03 +/- 0.05 mPas (P < .01) while the triglyceride concentration remained unchanged. Triglycerides 13-25 fibrinogen beta chain Homo sapiens 69-79 10938899-5 2000 When fibroblasts were grown on surfaces precoated with a mixture of fibrinogen and thrombin-stimulated platelets, the 3H-thymidine uptake (196,645 +/- 56,864 cpm/ml) was increased, in comparison to fibroblasts grown on uncoated surfaces, in medium supplemented with FBS (28,855 +/- 7329 cpm/ml). 3h-thymidine 118-130 fibrinogen beta chain Homo sapiens 68-78 10877212-8 2000 Second, hypertriglyceridemic samples (n = 7) were pumped through the fibrinogen-depleting column, which reduced the fibrinogen concentration from 4.29 +/- 0.79 to 1.62 +/- 0.69 g/L (P < .001) and PV from 1.42 +/- 0.06 to 1.03 +/- 0.05 mPas (P < .01) while the triglyceride concentration remained unchanged. Triglycerides 13-25 fibrinogen beta chain Homo sapiens 116-126 10847630-5 2000 The induction of beta-fibrinogen mRNA by IL-6, a Stat3 dependent process, is attenuated in AdiNOS-transduced cells and partially reversed by L-NMA. l-nma 141-146 fibrinogen beta chain Homo sapiens 17-32 10828478-11 2000 Multivariate analyses revealed that lower plasma fibrinogen was associated with low to normal body mass index in women, and with dietary intakes compatible with prudent dietary guidelines in men and women (low intakes of animal protein; trans fatty acids and higher intakes of plant protein; dietary fibre, vitamin E, and iron, and a high dietary P/S ratio). Iron 322-326 fibrinogen beta chain Homo sapiens 49-59 10828478-11 2000 Multivariate analyses revealed that lower plasma fibrinogen was associated with low to normal body mass index in women, and with dietary intakes compatible with prudent dietary guidelines in men and women (low intakes of animal protein; trans fatty acids and higher intakes of plant protein; dietary fibre, vitamin E, and iron, and a high dietary P/S ratio). Trans Fatty Acids 237-254 fibrinogen beta chain Homo sapiens 49-59 10828478-12 2000 Subjects in the higher quartiles of plasma fibrinogen had significantly lower iron, vitamin E, and vitamin B6 (women) status. Iron 78-82 fibrinogen beta chain Homo sapiens 43-53 10828478-11 2000 Multivariate analyses revealed that lower plasma fibrinogen was associated with low to normal body mass index in women, and with dietary intakes compatible with prudent dietary guidelines in men and women (low intakes of animal protein; trans fatty acids and higher intakes of plant protein; dietary fibre, vitamin E, and iron, and a high dietary P/S ratio). Vitamin E 307-316 fibrinogen beta chain Homo sapiens 49-59 10828478-12 2000 Subjects in the higher quartiles of plasma fibrinogen had significantly lower iron, vitamin E, and vitamin B6 (women) status. Vitamin E 84-93 fibrinogen beta chain Homo sapiens 43-53 10828478-12 2000 Subjects in the higher quartiles of plasma fibrinogen had significantly lower iron, vitamin E, and vitamin B6 (women) status. Vitamin B 6 99-109 fibrinogen beta chain Homo sapiens 43-53 10789612-8 2000 Effects on plasma fibrinogen levels were significantly favorable for Niaspan compared with gemfibrozil (P<.02), as gemfibrozil increased the fibrinogen level (from 5% to 9%) and Niaspan tended to decrease the fibrinogen level (from -1% to -6%). Niacin 69-76 fibrinogen beta chain Homo sapiens 18-28 10910028-3 2000 However, conflicting data have been published concerning the effect of atorvastatin on fibrinogen concentration. Atorvastatin 71-83 fibrinogen beta chain Homo sapiens 87-97 10928468-9 2000 A synthetic peptide corresponding to Bbeta261-272 competitively inhibited the binding of D73H to the Bbeta chain of denatured intact fibrinogen and reduced and denatured Bbeta chain in Western blots, experimentally proving the validity of these predictive algorithms. bbeta 37-42 fibrinogen beta chain Homo sapiens 133-143 11200464-0 2000 [Cytokine profile and fibrinogen level in blood plasma in diabetic foot under the action of heparin]. Heparin 92-99 fibrinogen beta chain Homo sapiens 22-32 11775909-7 2000 After 3-month HRT, the fibrinogen levels in estrogen group and estrogen plus progesterone group significantly decreased and further decreased after 6-month HRT, as compared with before HRT. Progesterone 77-89 fibrinogen beta chain Homo sapiens 23-33 10789612-8 2000 Effects on plasma fibrinogen levels were significantly favorable for Niaspan compared with gemfibrozil (P<.02), as gemfibrozil increased the fibrinogen level (from 5% to 9%) and Niaspan tended to decrease the fibrinogen level (from -1% to -6%). Gemfibrozil 91-102 fibrinogen beta chain Homo sapiens 18-28 10789612-8 2000 Effects on plasma fibrinogen levels were significantly favorable for Niaspan compared with gemfibrozil (P<.02), as gemfibrozil increased the fibrinogen level (from 5% to 9%) and Niaspan tended to decrease the fibrinogen level (from -1% to -6%). Gemfibrozil 118-129 fibrinogen beta chain Homo sapiens 144-154 10789612-8 2000 Effects on plasma fibrinogen levels were significantly favorable for Niaspan compared with gemfibrozil (P<.02), as gemfibrozil increased the fibrinogen level (from 5% to 9%) and Niaspan tended to decrease the fibrinogen level (from -1% to -6%). Gemfibrozil 118-129 fibrinogen beta chain Homo sapiens 144-154 10789612-9 2000 CONCLUSIONS: In patients with a low baseline HDL-C level, Niaspan at its higher doses provided up to 2-fold greater HDL-C increases, decreases in lipoprotein(a), improvements in lipoprotein cholesterol ratios, and lower fibrinogen levels compared with gemfibrozil. Niacin 58-65 fibrinogen beta chain Homo sapiens 220-230 10749687-6 2000 In contrast, direct activation of PKC with the active phorbol ester PMA induced the tyrosine phosphorylation of Pyk2 and FAK but only when platelets were fully aggregated with the exogenous addition of fibrinogen (the ligand for alphaIIbbeta3 integrin). Phorbol Esters 54-67 fibrinogen beta chain Homo sapiens 202-212 10749687-6 2000 In contrast, direct activation of PKC with the active phorbol ester PMA induced the tyrosine phosphorylation of Pyk2 and FAK but only when platelets were fully aggregated with the exogenous addition of fibrinogen (the ligand for alphaIIbbeta3 integrin). Tyrosine 84-92 fibrinogen beta chain Homo sapiens 202-212 10749687-7 2000 Furthermore, PMA-induced Pyk2 (and FAK) tyrosine phosphorylation was also observed when platelets adhered to immobilized fibrinogen. Tetradecanoylphorbol Acetate 13-16 fibrinogen beta chain Homo sapiens 121-131 10749687-7 2000 Furthermore, PMA-induced Pyk2 (and FAK) tyrosine phosphorylation was also observed when platelets adhered to immobilized fibrinogen. Tyrosine 40-48 fibrinogen beta chain Homo sapiens 121-131 10713316-2 2000 The total amount of phosphate bound to fibrinogen and the concentration of fibrinogen was determined in samples withdrawn immediately after submission and after thrombolytic treatment. Phosphates 20-29 fibrinogen beta chain Homo sapiens 39-49 10713316-1 2000 Fibrinogen was purified by protamine-agarose chromatography from plasma from three patients after their submission to hospital due to acute myocardial infarction. Sepharose 37-44 fibrinogen beta chain Homo sapiens 0-10 10713316-4 2000 In patients treated with streptokinase, the new circulating fibrinogen was homogeneous according to the single alpha-band seen after sodium dodecyl sulphate polyacrylamide gel electrophoresis analysis under reducing conditions, whereas fibrinogen from the recombinant tissue plasminogen activator-treated patient as well as healthy controls exhibited two alpha-bands in the 66-kDa region. Sodium Dodecyl Sulfate 133-156 fibrinogen beta chain Homo sapiens 60-70 10713316-5 2000 The molar ratios of phosphate to fibrinogen of healthy controls and commercial fibrinogen were 0.82 (+/-0.04) and 0. Phosphates 20-29 fibrinogen beta chain Homo sapiens 79-89 10713316-9 2000 In conclusion we show in this report that after streptokinase treatment of patients with acute myocardial infarction, the new Aalpha-chain of fibrinogen was a homogeneous single 66-kDa band on sodium dodecyl sulphate polyacrylamide gel electrophoresis under reducing conditions and that the degree of phosphorylation of plasma fibrinogen was elevated, approaching the theoretical limit of 4 mol phosphate/mol fibrinogen. Sodium Dodecyl Sulfate 193-216 fibrinogen beta chain Homo sapiens 142-152 10713316-9 2000 In conclusion we show in this report that after streptokinase treatment of patients with acute myocardial infarction, the new Aalpha-chain of fibrinogen was a homogeneous single 66-kDa band on sodium dodecyl sulphate polyacrylamide gel electrophoresis under reducing conditions and that the degree of phosphorylation of plasma fibrinogen was elevated, approaching the theoretical limit of 4 mol phosphate/mol fibrinogen. polyacrylamide 217-231 fibrinogen beta chain Homo sapiens 142-152 10763249-3 2000 The elution of fibrinogen and albumin from coated and unmodified gold surfaces by sodium dodecyl sulfate was studied with respect to different adsorption times and protein concentrations. Sodium Dodecyl Sulfate 82-104 fibrinogen beta chain Homo sapiens 15-25 11447466-11 2000 The significant relationships between triglycerides, blood pressure, weight, percentage of high-density lipoprotein (HDL) cholesterol and fibrinogen further suggest a clustering of risk factors all known to be associated with an insulin-resistant state. Triglycerides 38-51 fibrinogen beta chain Homo sapiens 138-148 11447466-11 2000 The significant relationships between triglycerides, blood pressure, weight, percentage of high-density lipoprotein (HDL) cholesterol and fibrinogen further suggest a clustering of risk factors all known to be associated with an insulin-resistant state. Cholesterol 122-133 fibrinogen beta chain Homo sapiens 138-148 10753983-9 2000 After 6 weeks of therapy with dose-adjusted warfarin (INR 2.0 to 3.0), there was a significant decrease in plasma fibrinogen (P=0.023) and fibrin D-dimer (P=0.0067) levels. Warfarin 44-52 fibrinogen beta chain Homo sapiens 114-124 10780315-2 2000 AIM OF THE STUDY: We studied the effects of fluvastatin and bezafibrate in monotherapy and in combination on plasma fibrinogen, t-plasminogen activator inhibitor (PAI-1) and C reactive protein (CRP) in patients with coronary artery disease (CAD) and mixed hyperlipidaemia. Bezafibrate 60-71 fibrinogen beta chain Homo sapiens 116-126 10706934-7 2000 The polyamine bound to both glycocalicin and platelets, and it inhibited the fibrinogen binding to stimulated platelets. Polyamines 4-13 fibrinogen beta chain Homo sapiens 77-87 10780315-4 2000 RESULTS: Plasma fibrinogen significantly decreased after treatment with the combinations fluvastatin+bezafibrate (-14 and -16%) and with bezafibrate monotherapy (-9%). Fluvastatin 89-100 fibrinogen beta chain Homo sapiens 16-26 10780315-4 2000 RESULTS: Plasma fibrinogen significantly decreased after treatment with the combinations fluvastatin+bezafibrate (-14 and -16%) and with bezafibrate monotherapy (-9%). Bezafibrate 101-112 fibrinogen beta chain Homo sapiens 16-26 10780315-4 2000 RESULTS: Plasma fibrinogen significantly decreased after treatment with the combinations fluvastatin+bezafibrate (-14 and -16%) and with bezafibrate monotherapy (-9%). Bezafibrate 137-148 fibrinogen beta chain Homo sapiens 16-26 10780315-8 2000 CONCLUSIONS: The combined effects on fibrinogen and plasma lipids achieved by fluvastatin and bezafibrate combination treatment might be more useful than the simple reduction of cholesterol in preventing ischaemic cardiovascular disease. Fluvastatin 78-89 fibrinogen beta chain Homo sapiens 37-47 10704650-1 2000 In this study we examined in 100 patients testing positive for Helicobacter pylori infection whether successful eradication therapy with pantoprazole, clarithromycin, and metronidazole alters fibrinogen and other acute phase response markers. Pantoprazole 137-149 fibrinogen beta chain Homo sapiens 192-202 10704650-1 2000 In this study we examined in 100 patients testing positive for Helicobacter pylori infection whether successful eradication therapy with pantoprazole, clarithromycin, and metronidazole alters fibrinogen and other acute phase response markers. Clarithromycin 151-165 fibrinogen beta chain Homo sapiens 192-202 10704650-1 2000 In this study we examined in 100 patients testing positive for Helicobacter pylori infection whether successful eradication therapy with pantoprazole, clarithromycin, and metronidazole alters fibrinogen and other acute phase response markers. Metronidazole 171-184 fibrinogen beta chain Homo sapiens 192-202 10704657-0 2000 Singlet oxygen inactivates fibrinogen, factor V, factor VIII, factor X, and platelet aggregation of human blood. Singlet Oxygen 0-14 fibrinogen beta chain Homo sapiens 27-37 10692309-0 2000 Time and force dependence of the rupture of glycoprotein IIb-IIIa-fibrinogen bonds between latex spheres. Latex 91-96 fibrinogen beta chain Homo sapiens 66-76 10692309-2 2000 Flow cytometry with fluorescein isothiocyanate-fibrinogen showed than an average of 22,500 molecules of active GPIIb-IIIa were captured per sphere, with a mean K(d) = 56 nM for fibrinogen binding. Fluorescein 20-31 fibrinogen beta chain Homo sapiens 47-57 10738438-9 2000 Decreases in nitration of 4-hydroxyphenylacetic acid also were seen with titanium in the presence of fibrinogen, 10% fetal calf serum, and sodium bicarbonate buffer. 4-hydroxyphenylacetic acid 26-52 fibrinogen beta chain Homo sapiens 101-111 10733124-0 2000 Selective augmentations of intratumoral 5-fluorouracil concentration by local immunotherapy with OK-432 and fibrinogen. Fluorouracil 40-54 fibrinogen beta chain Homo sapiens 108-118 10738438-9 2000 Decreases in nitration of 4-hydroxyphenylacetic acid also were seen with titanium in the presence of fibrinogen, 10% fetal calf serum, and sodium bicarbonate buffer. Titanium 73-81 fibrinogen beta chain Homo sapiens 101-111 10733124-12 2000 CONCLUSION: In patients with colorectal cancer, selective high 5-fluorouracil concentration in the cancer tissue could be achieved by a combination of 5"-deoxy-5-fluorouridine and local immunotherapy with a mixture of OK-432 and fibrinogen. Fluorouracil 63-77 fibrinogen beta chain Homo sapiens 218-239 10699284-1 2000 In recent years, major progress has been made in the design and synthesis of fibrinogen antagonists, which are peptidomimetic Arg-Gly-Asp (RGD) analogs. Arginine 126-129 fibrinogen beta chain Homo sapiens 77-87 10699284-1 2000 In recent years, major progress has been made in the design and synthesis of fibrinogen antagonists, which are peptidomimetic Arg-Gly-Asp (RGD) analogs. Glycine 130-133 fibrinogen beta chain Homo sapiens 77-87 10699284-1 2000 In recent years, major progress has been made in the design and synthesis of fibrinogen antagonists, which are peptidomimetic Arg-Gly-Asp (RGD) analogs. Aspartic Acid 134-137 fibrinogen beta chain Homo sapiens 77-87 10867212-3 2000 The effect of heparin-induced extracorporeal LDL/fibrinogen precipitation (HELP), a method for safe and immediate reduction of parameters relevant to hemorheology, such as plasma fibrinogen and the lipoproteins, was investigated in 141 patients with MID. Heparin 14-21 fibrinogen beta chain Homo sapiens 49-59 10867212-3 2000 The effect of heparin-induced extracorporeal LDL/fibrinogen precipitation (HELP), a method for safe and immediate reduction of parameters relevant to hemorheology, such as plasma fibrinogen and the lipoproteins, was investigated in 141 patients with MID. Heparin 14-21 fibrinogen beta chain Homo sapiens 179-189 10677284-4 2000 The initial panning recovered phage that bore the consensus motif Gly-Pro-Arg-Pro, a known fibrinogen-binding motif. glycyl-prolyl-arginyl-proline 66-81 fibrinogen beta chain Homo sapiens 91-101 10677284-10 2000 A third round of panning performed in the presence of both the fibrinogen- and the C1q- blocking peptides yielded phage with a new peptide motif (Asn-Pro-Phe) that also bound specifically to C1q, apparently at a new site. Asn-Pro-Phe 146-157 fibrinogen beta chain Homo sapiens 63-73 10728949-4 2000 A significant univariate correlation was observed between the concentration of cholesterol carried in small, dense LDL particles and plasma fibrinogen concentration (r = 0.17, p = 0.01). Cholesterol 79-90 fibrinogen beta chain Homo sapiens 140-150 10728957-3 2000 Patients receiving the oral glycoprotein IIb-IIIa inhibitor orbofiban in the OPUS -TIMI 16 trial had a paradoxical increase in platelet reactivity with respect to both fibrinogen binding and alpha-granule degranulation, suggesting a mechanism for the lack of efficacy of orbofiban in the trial. orbofiban 60-69 fibrinogen beta chain Homo sapiens 168-178 10657942-0 2000 Cell type-specific regulation of fibrinogen expression in lung epithelial cells by dexamethasone and interleukin-1beta. Dexamethasone 83-96 fibrinogen beta chain Homo sapiens 33-43 10669661-3 2000 Fibrinogen increased more in older participants, those with or who developed diabetes, those who at any time smoked, and those whose plasma HDL cholesterol or triglycerides decreased and increased less in female participants who started hormonal replacement therapy. Cholesterol 144-155 fibrinogen beta chain Homo sapiens 0-10 10669661-3 2000 Fibrinogen increased more in older participants, those with or who developed diabetes, those who at any time smoked, and those whose plasma HDL cholesterol or triglycerides decreased and increased less in female participants who started hormonal replacement therapy. Triglycerides 159-172 fibrinogen beta chain Homo sapiens 0-10 10691848-0 2000 Defective fibrinogen polymerization associated with a novel gamma279Ala-->Asp mutation. gamma279ala 60-71 fibrinogen beta chain Homo sapiens 10-20 10691848-0 2000 Defective fibrinogen polymerization associated with a novel gamma279Ala-->Asp mutation. Aspartic Acid 74-77 fibrinogen beta chain Homo sapiens 10-20 10812581-5 2000 Our aim was to evaluate the efficacy and safety of ciprofibrate in improving dyslipoproteinemia and its effect on fibrinogen plasma concentrations, carbohydrate metabolism variations and insulin action. ciprofibrate 51-63 fibrinogen beta chain Homo sapiens 114-124 10812581-16 2000 CONCLUSIONS: Ciprofibrate has a potent hypolipidemic effect, especially a decrease in triglycerides, VLDL and fibrinogen, and an increase in HDL-cholesterol, but does not influence glycemic control nor insulin action. ciprofibrate 13-25 fibrinogen beta chain Homo sapiens 110-120 10618368-3 2000 We isolated the transglutaminase-modified, mostly monomeric form (92-96%) of fibrinogen with a N(epsilon)(gamma-glutamyl)lysine content of approximately 1.6 moles/mole of fibrinogen. )(gamma-glutamyl)lysine 104-127 fibrinogen beta chain Homo sapiens 77-87 10634338-11 2000 Among subjects with glucose intolerance, levels of PAI-1 and tPA antigen in men and women (P<.01 for trend) and vWF antigen in men (P<.05 for trend) increased significantly across insulin quintiles, but levels of factor VII antigen, fibrinogen, and plasma viscosity did not increase. Glucose 20-27 fibrinogen beta chain Homo sapiens 239-249 10634829-7 2000 Increasing levels of alcohol consumption were associated with increases in tPA and plasminogen activator inhibitor (PAI-1) activity and with decreases in fibrinogen and white cell count. Alcohols 21-28 fibrinogen beta chain Homo sapiens 154-164 10644290-0 2000 More on the effect of atorvastatin on plasma fibrinogen levels in primary hypercholesterolaemia. Atorvastatin 22-34 fibrinogen beta chain Homo sapiens 45-55 11096193-9 2000 In 14 out of the 16 vulval lichen sclerosus specimens and the extragenital lichen sclerosus specimen fibrinogen immunostaining was increased in the upper dermis which corresponded--in haematoxylin and eosin staining --to the zone of sclerosis. Hematoxylin 184-196 fibrinogen beta chain Homo sapiens 101-111 11096193-9 2000 In 14 out of the 16 vulval lichen sclerosus specimens and the extragenital lichen sclerosus specimen fibrinogen immunostaining was increased in the upper dermis which corresponded--in haematoxylin and eosin staining --to the zone of sclerosis. Eosine Yellowish-(YS) 201-206 fibrinogen beta chain Homo sapiens 101-111 10885504-0 2000 Adhesion of blood platelets to collagen and fibrinogen after treatment with cisplatin and its complex with glutathione. Cisplatin 76-85 fibrinogen beta chain Homo sapiens 44-54 10865942-0 2000 Interaction of fibrinogen with saphenous vein endothelial cells stimulates tyrosine phosphorylation of cortactin. Tyrosine 75-83 fibrinogen beta chain Homo sapiens 15-25 10885504-0 2000 Adhesion of blood platelets to collagen and fibrinogen after treatment with cisplatin and its complex with glutathione. Glutathione 107-118 fibrinogen beta chain Homo sapiens 44-54 10885504-3 2000 The aim of the present study was to evaluate the effect of CDDP on the first step in blood platelet activation-platelet adhesion, induced by thrombin or adenosine diphosphate (ADP), to collagen and fibrinogen. Cisplatin 59-63 fibrinogen beta chain Homo sapiens 198-208 10885504-5 2000 Pretreatment of blood platelets with cisplatin (0.1-20 microM) caused a dose- and time-dependent reduction of platelet adhesion to collagen and fibrinogen (p <0.05). Cisplatin 37-46 fibrinogen beta chain Homo sapiens 144-154 10865942-2 2000 We have investigated the effect of fibrinogen on the tyrosine phosphorylation of cortactin, a cytoskeletal protein in human saphenous vein endothelial cells (HSVECs). Tyrosine 53-61 fibrinogen beta chain Homo sapiens 35-45 10865942-3 2000 Incubation of HSVECs with fibrinogen (0-4 microM) caused a concentration-dependent increase in the tyrosine phosphorylation of cortactin. Tyrosine 99-107 fibrinogen beta chain Homo sapiens 26-36 10839560-6 2000 Furthermore, flow cytometric analysis showed decreases in the binding of fibrinogen to activated platelets by the addition of PGI2 or SNP. Epoprostenol 126-130 fibrinogen beta chain Homo sapiens 73-83 11399583-6 2000 After a week with ATRA treatment, fibrinogen level improved and "D" dimers decreased, so as observed slowly maturation of leukemic leucocytes. Tretinoin 18-22 fibrinogen beta chain Homo sapiens 34-44 11263807-9 2000 Blood compatibility of the polymer alloy was evaluated by observation of fibrinogen adsorption and platelet adhesion from human plasma. Polymers 27-34 fibrinogen beta chain Homo sapiens 73-83 12845727-3 2000 The results showed that platelet surface binding sites of fibrinogen were 65.38 +/- 3.62 in the resting state and 65.25 +/- 5.78 after activated by adenosine diphosphate, showing no significant difference as compared with control group (P > 0.05). Adenosine Diphosphate 148-169 fibrinogen beta chain Homo sapiens 58-68 10622702-0 1999 Peroxynitrite-mediated oxidation of fibrinogen inhibits clot formation. Peroxynitrous Acid 0-13 fibrinogen beta chain Homo sapiens 36-46 10622702-1 1999 The clotting activity of human fibrinogen was fully inhibited in vitro by peroxynitrite. Peroxynitrous Acid 74-87 fibrinogen beta chain Homo sapiens 31-41 10622702-2 1999 The decrease of activity followed an exponential function and the concentration of peroxynitrite needed to inhibit 50% of fibrinogen clotting was 22 microM at 25 degrees C. The oxidative modification(s) induced by the peroxynitrite system (i.e. ONOO-, ONOOH and ONOOH*) appeared specifically to affect fibrin clot formation (through the inhibition of fibrinogen polymerization) since the interaction of peroxynitrite-modified fibrinogen with thrombin appeared to be unaffected. Peroxynitrous Acid 83-96 fibrinogen beta chain Homo sapiens 122-132 10622702-2 1999 The decrease of activity followed an exponential function and the concentration of peroxynitrite needed to inhibit 50% of fibrinogen clotting was 22 microM at 25 degrees C. The oxidative modification(s) induced by the peroxynitrite system (i.e. ONOO-, ONOOH and ONOOH*) appeared specifically to affect fibrin clot formation (through the inhibition of fibrinogen polymerization) since the interaction of peroxynitrite-modified fibrinogen with thrombin appeared to be unaffected. Peroxynitrous Acid 83-96 fibrinogen beta chain Homo sapiens 351-361 10622702-2 1999 The decrease of activity followed an exponential function and the concentration of peroxynitrite needed to inhibit 50% of fibrinogen clotting was 22 microM at 25 degrees C. The oxidative modification(s) induced by the peroxynitrite system (i.e. ONOO-, ONOOH and ONOOH*) appeared specifically to affect fibrin clot formation (through the inhibition of fibrinogen polymerization) since the interaction of peroxynitrite-modified fibrinogen with thrombin appeared to be unaffected. Peroxynitrous Acid 83-96 fibrinogen beta chain Homo sapiens 351-361 10622702-2 1999 The decrease of activity followed an exponential function and the concentration of peroxynitrite needed to inhibit 50% of fibrinogen clotting was 22 microM at 25 degrees C. The oxidative modification(s) induced by the peroxynitrite system (i.e. ONOO-, ONOOH and ONOOH*) appeared specifically to affect fibrin clot formation (through the inhibition of fibrinogen polymerization) since the interaction of peroxynitrite-modified fibrinogen with thrombin appeared to be unaffected. Peroxynitrous Acid 218-231 fibrinogen beta chain Homo sapiens 122-132 10622702-2 1999 The decrease of activity followed an exponential function and the concentration of peroxynitrite needed to inhibit 50% of fibrinogen clotting was 22 microM at 25 degrees C. The oxidative modification(s) induced by the peroxynitrite system (i.e. ONOO-, ONOOH and ONOOH*) appeared specifically to affect fibrin clot formation (through the inhibition of fibrinogen polymerization) since the interaction of peroxynitrite-modified fibrinogen with thrombin appeared to be unaffected. Peroxynitrous Acid 218-231 fibrinogen beta chain Homo sapiens 351-361 10622702-2 1999 The decrease of activity followed an exponential function and the concentration of peroxynitrite needed to inhibit 50% of fibrinogen clotting was 22 microM at 25 degrees C. The oxidative modification(s) induced by the peroxynitrite system (i.e. ONOO-, ONOOH and ONOOH*) appeared specifically to affect fibrin clot formation (through the inhibition of fibrinogen polymerization) since the interaction of peroxynitrite-modified fibrinogen with thrombin appeared to be unaffected. Peroxynitrous Acid 218-231 fibrinogen beta chain Homo sapiens 351-361 10622702-2 1999 The decrease of activity followed an exponential function and the concentration of peroxynitrite needed to inhibit 50% of fibrinogen clotting was 22 microM at 25 degrees C. The oxidative modification(s) induced by the peroxynitrite system (i.e. ONOO-, ONOOH and ONOOH*) appeared specifically to affect fibrin clot formation (through the inhibition of fibrinogen polymerization) since the interaction of peroxynitrite-modified fibrinogen with thrombin appeared to be unaffected. onoo 245-249 fibrinogen beta chain Homo sapiens 122-132 10622702-2 1999 The decrease of activity followed an exponential function and the concentration of peroxynitrite needed to inhibit 50% of fibrinogen clotting was 22 microM at 25 degrees C. The oxidative modification(s) induced by the peroxynitrite system (i.e. ONOO-, ONOOH and ONOOH*) appeared specifically to affect fibrin clot formation (through the inhibition of fibrinogen polymerization) since the interaction of peroxynitrite-modified fibrinogen with thrombin appeared to be unaffected. onooh 252-257 fibrinogen beta chain Homo sapiens 122-132 10622702-2 1999 The decrease of activity followed an exponential function and the concentration of peroxynitrite needed to inhibit 50% of fibrinogen clotting was 22 microM at 25 degrees C. The oxidative modification(s) induced by the peroxynitrite system (i.e. ONOO-, ONOOH and ONOOH*) appeared specifically to affect fibrin clot formation (through the inhibition of fibrinogen polymerization) since the interaction of peroxynitrite-modified fibrinogen with thrombin appeared to be unaffected. onooh 262-267 fibrinogen beta chain Homo sapiens 122-132 10622702-2 1999 The decrease of activity followed an exponential function and the concentration of peroxynitrite needed to inhibit 50% of fibrinogen clotting was 22 microM at 25 degrees C. The oxidative modification(s) induced by the peroxynitrite system (i.e. ONOO-, ONOOH and ONOOH*) appeared specifically to affect fibrin clot formation (through the inhibition of fibrinogen polymerization) since the interaction of peroxynitrite-modified fibrinogen with thrombin appeared to be unaffected. Peroxynitrous Acid 218-231 fibrinogen beta chain Homo sapiens 122-132 10622702-2 1999 The decrease of activity followed an exponential function and the concentration of peroxynitrite needed to inhibit 50% of fibrinogen clotting was 22 microM at 25 degrees C. The oxidative modification(s) induced by the peroxynitrite system (i.e. ONOO-, ONOOH and ONOOH*) appeared specifically to affect fibrin clot formation (through the inhibition of fibrinogen polymerization) since the interaction of peroxynitrite-modified fibrinogen with thrombin appeared to be unaffected. Peroxynitrous Acid 218-231 fibrinogen beta chain Homo sapiens 351-361 10622702-2 1999 The decrease of activity followed an exponential function and the concentration of peroxynitrite needed to inhibit 50% of fibrinogen clotting was 22 microM at 25 degrees C. The oxidative modification(s) induced by the peroxynitrite system (i.e. ONOO-, ONOOH and ONOOH*) appeared specifically to affect fibrin clot formation (through the inhibition of fibrinogen polymerization) since the interaction of peroxynitrite-modified fibrinogen with thrombin appeared to be unaffected. Peroxynitrous Acid 218-231 fibrinogen beta chain Homo sapiens 351-361 10622702-3 1999 The addition of NaHCO3 decreased the peroxynitrite effect on fibrinogen clotting, suggesting that the reactive species formed by the reaction of CO2 with peroxynitrite are less efficient oxidants of peroxynitrite itself. Sodium Bicarbonate 16-22 fibrinogen beta chain Homo sapiens 61-71 10622702-3 1999 The addition of NaHCO3 decreased the peroxynitrite effect on fibrinogen clotting, suggesting that the reactive species formed by the reaction of CO2 with peroxynitrite are less efficient oxidants of peroxynitrite itself. Peroxynitrous Acid 37-50 fibrinogen beta chain Homo sapiens 61-71 10622702-3 1999 The addition of NaHCO3 decreased the peroxynitrite effect on fibrinogen clotting, suggesting that the reactive species formed by the reaction of CO2 with peroxynitrite are less efficient oxidants of peroxynitrite itself. N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)-4-((4-fluorobenzyl)oxy)pyridine-2,6-dicarboxamide 145-148 fibrinogen beta chain Homo sapiens 61-71 10622702-3 1999 The addition of NaHCO3 decreased the peroxynitrite effect on fibrinogen clotting, suggesting that the reactive species formed by the reaction of CO2 with peroxynitrite are less efficient oxidants of peroxynitrite itself. Peroxynitrous Acid 154-167 fibrinogen beta chain Homo sapiens 61-71 10622702-3 1999 The addition of NaHCO3 decreased the peroxynitrite effect on fibrinogen clotting, suggesting that the reactive species formed by the reaction of CO2 with peroxynitrite are less efficient oxidants of peroxynitrite itself. Peroxynitrous Acid 154-167 fibrinogen beta chain Homo sapiens 61-71 10622702-4 1999 Similar effects were observed after addition of bilirubin, which also exerted a significant protection against peroxynitrite-mediated modification of fibrinogen. Bilirubin 48-57 fibrinogen beta chain Homo sapiens 150-160 10622702-4 1999 Similar effects were observed after addition of bilirubin, which also exerted a significant protection against peroxynitrite-mediated modification of fibrinogen. Peroxynitrous Acid 111-124 fibrinogen beta chain Homo sapiens 150-160 10591680-6 1999 Compared with placebo, both raloxifene and CEEs lowered the level of low density lipoprotein cholesterol by 0.53 to 0.79 mmol/L (all P<0.04) and lowered, at 24 months, the level of fibrinogen by 0.71 to 0.86 g/L (all P<0.05). Raloxifene Hydrochloride 28-38 fibrinogen beta chain Homo sapiens 184-194 10591680-12 1999 Our findings suggest that in healthy postmenopausal women, raloxifene and estrogen monotherapy have similar beneficial effects on low density lipoprotein cholesterol and fibrinogen levels. Raloxifene Hydrochloride 59-69 fibrinogen beta chain Homo sapiens 170-180 10572095-0 1999 Fibrinogen Niigata with impaired fibrin assembly: an inherited dysfibrinogen with a Bbeta Asn-160 to Ser substitution associated with extra glycosylation at Bbeta Asn-158. niigata 11-18 fibrinogen beta chain Homo sapiens 0-10 10572095-0 1999 Fibrinogen Niigata with impaired fibrin assembly: an inherited dysfibrinogen with a Bbeta Asn-160 to Ser substitution associated with extra glycosylation at Bbeta Asn-158. bbeta 84-89 fibrinogen beta chain Homo sapiens 0-10 10572095-0 1999 Fibrinogen Niigata with impaired fibrin assembly: an inherited dysfibrinogen with a Bbeta Asn-160 to Ser substitution associated with extra glycosylation at Bbeta Asn-158. Asparagine 90-93 fibrinogen beta chain Homo sapiens 0-10 10572095-1 1999 A novel BbetaAsn-160 (TAA) to Ser (TGA) substitution has been identified in fibrinogen Niigata derived from a 64-year-old asymptomatic woman, who is heterozygotic for this abnormality. Serine 30-33 fibrinogen beta chain Homo sapiens 76-86 10572095-1 1999 A novel BbetaAsn-160 (TAA) to Ser (TGA) substitution has been identified in fibrinogen Niigata derived from a 64-year-old asymptomatic woman, who is heterozygotic for this abnormality. niigata 87-94 fibrinogen beta chain Homo sapiens 76-86 10572095-4 1999 Enzymatic removal of all the N-linked oligosaccharides from fibrinogen Niigata accelerated fibrin monomer polymerization that reached the level of untreated normal fibrin monomers, but the thrombin time was prolonged from 18.2 seconds to 113 seconds (normal: 11.2 seconds to 8.9 seconds). n-linked oligosaccharides 29-54 fibrinogen beta chain Homo sapiens 60-70 10572095-4 1999 Enzymatic removal of all the N-linked oligosaccharides from fibrinogen Niigata accelerated fibrin monomer polymerization that reached the level of untreated normal fibrin monomers, but the thrombin time was prolonged from 18.2 seconds to 113 seconds (normal: 11.2 seconds to 8.9 seconds). niigata 71-78 fibrinogen beta chain Homo sapiens 60-70 11078305-8 2000 Thus, atorvastatin 80 mg/day produced marked reductions in serum low-density lipoprotein cholesterol (-53%), very low density lipoprotein cholesterol (-43%), and triglycerides levels (-35%), and significant changes in plasma viscosity as well as other hemorheologic-hemostatic parameters, but no changes in plasma fibrinogen levels. Atorvastatin 6-18 fibrinogen beta chain Homo sapiens 314-324 10580783-3 1999 In multiple linear regression models, the fibrinogen level was associated significantly and positively with white blood cell count (WBC) and total cholesterol, and inversely with HDL cholesterol and hematocrit in both study samples. Cholesterol 147-158 fibrinogen beta chain Homo sapiens 42-52 10580783-3 1999 In multiple linear regression models, the fibrinogen level was associated significantly and positively with white blood cell count (WBC) and total cholesterol, and inversely with HDL cholesterol and hematocrit in both study samples. Cholesterol 183-194 fibrinogen beta chain Homo sapiens 42-52 10745617-6 1999 Abciximab, tirofiban and eptifibatide all inhibit fibrinogen binding in a concentration of dependent manner. Tirofiban 11-20 fibrinogen beta chain Homo sapiens 50-60 10745617-6 1999 Abciximab, tirofiban and eptifibatide all inhibit fibrinogen binding in a concentration of dependent manner. Eptifibatide 25-37 fibrinogen beta chain Homo sapiens 50-60 10613655-6 1999 Furthermore, flow cytometric analyses demonstrated that H12 inhibited the binding of FITC-fibrinogen to ADP-activated rabbit platelets in a dose-dependent manner. Fluorescein-5-isothiocyanate 85-89 fibrinogen beta chain Homo sapiens 90-100 10613664-2 1999 First, SM-20302 selectively inhibited the interaction between human platelets and fibrinogen in vitro. SM 20302 7-15 fibrinogen beta chain Homo sapiens 82-92 10543983-6 1999 Divalent cations such as Mg(2+) and Mn(2+) were required for fibrinogen binding to the CD11c I-domain. magnesium ion 25-31 fibrinogen beta chain Homo sapiens 61-71 10543983-6 1999 Divalent cations such as Mg(2+) and Mn(2+) were required for fibrinogen binding to the CD11c I-domain. Manganese(2+) 36-42 fibrinogen beta chain Homo sapiens 61-71 10543983-7 1999 Also alanine substitutions on the putative metal binding sites of the CD11c I-domain such as Asp(242) and Tyr(209) reduced its ability to bind fibrinogen. Alanine 5-12 fibrinogen beta chain Homo sapiens 143-153 10543983-7 1999 Also alanine substitutions on the putative metal binding sites of the CD11c I-domain such as Asp(242) and Tyr(209) reduced its ability to bind fibrinogen. Metals 43-48 fibrinogen beta chain Homo sapiens 143-153 10543983-7 1999 Also alanine substitutions on the putative metal binding sites of the CD11c I-domain such as Asp(242) and Tyr(209) reduced its ability to bind fibrinogen. Aspartic Acid 93-96 fibrinogen beta chain Homo sapiens 143-153 10543983-7 1999 Also alanine substitutions on the putative metal binding sites of the CD11c I-domain such as Asp(242) and Tyr(209) reduced its ability to bind fibrinogen. Tyrosine 106-109 fibrinogen beta chain Homo sapiens 143-153 11721472-5 1999 CONCLUSION: It suggests that L-4-oxalysine and arabinosyl cytosine may even exhibit antimetastatic effect through thrombin-fibrinogen pathway, and thrombin might operate in tumor metastasis for only limited step but crucial to fibrin formation in tumor nodules. 4-oxalysine 29-42 fibrinogen beta chain Homo sapiens 123-133 11721472-5 1999 CONCLUSION: It suggests that L-4-oxalysine and arabinosyl cytosine may even exhibit antimetastatic effect through thrombin-fibrinogen pathway, and thrombin might operate in tumor metastasis for only limited step but crucial to fibrin formation in tumor nodules. Cytarabine 47-66 fibrinogen beta chain Homo sapiens 123-133 10583718-9 1999 In the whole study group, fibrinogen and PAI were significantly associated with glucose disposal. Glucose 80-87 fibrinogen beta chain Homo sapiens 26-36 10865942-4 2000 Fibrinogen (4 microM) and fibrinogen fragment D (4 microM) caused 250% and >450% increase in tyrosine phosphorylation of cortactin respectively, but fibrinogen fragment E (50 kDa form) was ineffective. Tyrosine 96-104 fibrinogen beta chain Homo sapiens 0-10 10865942-4 2000 Fibrinogen (4 microM) and fibrinogen fragment D (4 microM) caused 250% and >450% increase in tyrosine phosphorylation of cortactin respectively, but fibrinogen fragment E (50 kDa form) was ineffective. Tyrosine 96-104 fibrinogen beta chain Homo sapiens 26-36 10865942-6 2000 At physiological concentrations fibrinogen binds to receptors (probably including ICAM-1) on HSVECs, to increase tyrosine phosphorylation of cortactin. Tyrosine 113-121 fibrinogen beta chain Homo sapiens 32-42 10695765-0 1999 Fibrinogen Bbeta14 Arg-->Cys: further evidence for a role in thrombosis. Arginine 19-22 fibrinogen beta chain Homo sapiens 0-10 10510057-5 1999 Unfractionated heparin inhibited binding of the soluble ligands fibrinogen, factor X, and iC3b to Mac-1. Heparin 15-22 fibrinogen beta chain Homo sapiens 64-74 10510057-7 1999 Low-molecular-weight heparin also inhibits binding of fibrinogen to Mac-1. Heparin 21-28 fibrinogen beta chain Homo sapiens 54-64 10510057-8 1999 Additionally, flow cytometry of whole blood preparations of patients treated with unfractionated heparin revealed an inhibitory effect of heparin on the binding of fibrinogen to Mac-1 that correlates (n= 48, r=0.63, P<0.001) to the extent of prolongation of the activated partial thromboplastin time. Heparin 97-104 fibrinogen beta chain Homo sapiens 164-174 10510057-8 1999 Additionally, flow cytometry of whole blood preparations of patients treated with unfractionated heparin revealed an inhibitory effect of heparin on the binding of fibrinogen to Mac-1 that correlates (n= 48, r=0.63, P<0.001) to the extent of prolongation of the activated partial thromboplastin time. Heparin 138-145 fibrinogen beta chain Homo sapiens 164-174 10502580-2 1999 AIM: To examine in vitro whether phosphorylcholine coating of poly(methylmethacrylate) can reduce the adhesion of fibrinogen, fibrin, human scleral fibroblast and macrophage compared with current biomaterials used in the construction of glaucoma drainage devices. Phosphorylcholine 33-50 fibrinogen beta chain Homo sapiens 114-124 10695765-0 1999 Fibrinogen Bbeta14 Arg-->Cys: further evidence for a role in thrombosis. Cysteine 28-31 fibrinogen beta chain Homo sapiens 0-10 10695765-1 1999 A single base substitution (C-->T) in exon II of the Bbeta fibrinogen gene resulting in an Arg14-->Cys replacement was identified in a young woman with a history of recurrent thrombotic stroke. Cysteine 105-108 fibrinogen beta chain Homo sapiens 62-72 10522560-9 1999 Serum uric acid was significantly correlated with body weight, BP, glucose, fibrinogen, urea, creatinin and total cholesterol. Uric Acid 6-15 fibrinogen beta chain Homo sapiens 76-86 10528774-1 1999 PURPOSE: The aim of this article is to provide a concise and simple technical manual for manufacturing autologous fibrin tissue adhesive derived from the precipitation of fibrinogen using a combination of ethanol and freezing for surgery. Ethanol 205-212 fibrinogen beta chain Homo sapiens 171-181 10521087-3 1999 Preincubation of platelets with herbimycin A or Wortmannin inhibited fibrinogen binding by 80% to 92% and was accompanied by markedly decreased tyrosine phosphorylation of a range of proteins migrating between 60 kDa and 125 kDa. herbimycin 32-44 fibrinogen beta chain Homo sapiens 69-79 10521087-3 1999 Preincubation of platelets with herbimycin A or Wortmannin inhibited fibrinogen binding by 80% to 92% and was accompanied by markedly decreased tyrosine phosphorylation of a range of proteins migrating between 60 kDa and 125 kDa. Wortmannin 48-58 fibrinogen beta chain Homo sapiens 69-79 10521087-4 1999 The addition of inhibitors 5 minutes after adenosine diphosphate-induced fibrinogen binding also resulted in decreased tyrosine phosphorylation and dissociation of approximately 50% of bound fibrinogen within 60 minutes but failed to cause dissociation of irreversibly bound fibrinogen. Adenosine Diphosphate 43-64 fibrinogen beta chain Homo sapiens 73-83 10521087-4 1999 The addition of inhibitors 5 minutes after adenosine diphosphate-induced fibrinogen binding also resulted in decreased tyrosine phosphorylation and dissociation of approximately 50% of bound fibrinogen within 60 minutes but failed to cause dissociation of irreversibly bound fibrinogen. Tyrosine 119-127 fibrinogen beta chain Homo sapiens 73-83 10484537-1 1999 BACKGROUND: This study describes the first administration of YM337, the Fab fragment of a humanized monoclonal antibody against the fibrinogen GP IIb/IIIa receptor, in healthy male humans. ym337 61-66 fibrinogen beta chain Homo sapiens 132-142 10856986-4 1999 Clinical trials of bezafibrate, which is being used for its fibrinogen-lowering as well as lipid-modifying properties, are in progress. Bezafibrate 19-30 fibrinogen beta chain Homo sapiens 60-70 10527410-0 1999 Evidence of a phospholipid binding species within human fibrinogen preparations. Phospholipids 14-26 fibrinogen beta chain Homo sapiens 56-66 10527410-1 1999 Fibrinogen has been reported to interact with phospholipid; however, the properties of this binding interaction have not been characterized. Phospholipids 46-58 fibrinogen beta chain Homo sapiens 0-10 10527410-3 1999 Binding to 100% PS was saturable (apparent Kd=5 microM, Bmax=1.9 g protein/g lipid), reversible, and involved a minor subfraction of the fibrinogen preparation (3-6% of total protein). Phosphatidylserines 16-18 fibrinogen beta chain Homo sapiens 137-147 10527410-4 1999 Fibrinogen interacted minimally with phosphatidylinositol, and not at all with pure phosphatidylcholine (PC) or PC vesicles containing 5% glycosphingolipid (lactosylceramide, ganglioside GM3, ganglioside GD3). Phosphatidylinositols 37-57 fibrinogen beta chain Homo sapiens 0-10 10527410-4 1999 Fibrinogen interacted minimally with phosphatidylinositol, and not at all with pure phosphatidylcholine (PC) or PC vesicles containing 5% glycosphingolipid (lactosylceramide, ganglioside GM3, ganglioside GD3). G(M3) Ganglioside 175-190 fibrinogen beta chain Homo sapiens 0-10 10527410-9 1999 Computerized sequence analysis of fibrinogen revealed three candidate acidic phospholipid binding motifs located at position 143-210 in the alpha chain, and positions 59-77 and 101-139 in the beta chain. Phospholipids 77-89 fibrinogen beta chain Homo sapiens 34-44 10527410-10 1999 Further study of the PS binding activity of fibrinogen may lead to new insights about fibrinogen function. Phosphatidylserines 21-23 fibrinogen beta chain Homo sapiens 44-54 10527410-10 1999 Further study of the PS binding activity of fibrinogen may lead to new insights about fibrinogen function. Phosphatidylserines 21-23 fibrinogen beta chain Homo sapiens 86-96 10464255-2 1999 We found that inhibiting actin polymerization in unstimulated platelets with cytochalasin D or latrunculin A mimics the effects of platelet agonists by inducing fibrinogen binding to alpha(IIb)beta(3). Cytochalasin D 77-91 fibrinogen beta chain Homo sapiens 161-171 10464255-2 1999 We found that inhibiting actin polymerization in unstimulated platelets with cytochalasin D or latrunculin A mimics the effects of platelet agonists by inducing fibrinogen binding to alpha(IIb)beta(3). latrunculin A 95-108 fibrinogen beta chain Homo sapiens 161-171 10464255-3 1999 By contrast, stabilizing actin filaments with jasplakinolide prevented cytochalasin D-, latrunculin A-, and ADP-induced fibrinogen binding. jasplakinolide 46-60 fibrinogen beta chain Homo sapiens 120-130 10464255-3 1999 By contrast, stabilizing actin filaments with jasplakinolide prevented cytochalasin D-, latrunculin A-, and ADP-induced fibrinogen binding. Cytochalasin D 71-85 fibrinogen beta chain Homo sapiens 120-130 10464255-3 1999 By contrast, stabilizing actin filaments with jasplakinolide prevented cytochalasin D-, latrunculin A-, and ADP-induced fibrinogen binding. latrunculin A 88-101 fibrinogen beta chain Homo sapiens 120-130 10464255-3 1999 By contrast, stabilizing actin filaments with jasplakinolide prevented cytochalasin D-, latrunculin A-, and ADP-induced fibrinogen binding. Adenosine Diphosphate 108-111 fibrinogen beta chain Homo sapiens 120-130 10464255-4 1999 Cytochalasin D- and latrunculin A-induced fibrinogen was inhibited by ADP scavengers, suggesting that subthreshold concentrations of ADP provided the stimulus for the actin filament turnover required to see cytochalasin D and latrunculin A effects. Deuterium 13-14 fibrinogen beta chain Homo sapiens 42-52 10464255-4 1999 Cytochalasin D- and latrunculin A-induced fibrinogen was inhibited by ADP scavengers, suggesting that subthreshold concentrations of ADP provided the stimulus for the actin filament turnover required to see cytochalasin D and latrunculin A effects. latrunculin A 20-33 fibrinogen beta chain Homo sapiens 42-52 10464255-4 1999 Cytochalasin D- and latrunculin A-induced fibrinogen was inhibited by ADP scavengers, suggesting that subthreshold concentrations of ADP provided the stimulus for the actin filament turnover required to see cytochalasin D and latrunculin A effects. Adenosine Diphosphate 70-73 fibrinogen beta chain Homo sapiens 42-52 10464255-4 1999 Cytochalasin D- and latrunculin A-induced fibrinogen was inhibited by ADP scavengers, suggesting that subthreshold concentrations of ADP provided the stimulus for the actin filament turnover required to see cytochalasin D and latrunculin A effects. Adenosine Diphosphate 133-136 fibrinogen beta chain Homo sapiens 42-52 10464255-4 1999 Cytochalasin D- and latrunculin A-induced fibrinogen was inhibited by ADP scavengers, suggesting that subthreshold concentrations of ADP provided the stimulus for the actin filament turnover required to see cytochalasin D and latrunculin A effects. Cytochalasin D 207-221 fibrinogen beta chain Homo sapiens 42-52 10464255-4 1999 Cytochalasin D- and latrunculin A-induced fibrinogen was inhibited by ADP scavengers, suggesting that subthreshold concentrations of ADP provided the stimulus for the actin filament turnover required to see cytochalasin D and latrunculin A effects. latrunculin A 226-239 fibrinogen beta chain Homo sapiens 42-52 10596847-5 1999 High concentrations of fibrinogen were detected after very short blood material contact, both on uncoated as well as heparin-coated tubes. Heparin 117-124 fibrinogen beta chain Homo sapiens 23-33 10494763-8 1999 Quantitative dimensional analysis, which yielded structural information in three dimensions, indicates that surface-dependent structural deformation or spreading of fibrinogen increases according to the order: mica < APTES < OTS. mica 210-214 fibrinogen beta chain Homo sapiens 165-175 10515289-6 1999 The effect of HI117 and SJ9A4 on glycoprotein IIb/IIIa complex seems, however, to be indirect, because the HI1117 and SJ9A4-induced fibrinogen binding was reduced by pretreatment of platelets with sphingosine, aspirin, apyrase, and/or PGI2. Sphingosine 197-208 fibrinogen beta chain Homo sapiens 132-142 10494772-15 1999 Fibrinogen and tPA-ag are independently related with markers of insulin resistance, with the relation with fibrinogen being stronger in women than in men. Tetradecanoylphorbol Acetate 15-18 fibrinogen beta chain Homo sapiens 107-117 10515289-6 1999 The effect of HI117 and SJ9A4 on glycoprotein IIb/IIIa complex seems, however, to be indirect, because the HI1117 and SJ9A4-induced fibrinogen binding was reduced by pretreatment of platelets with sphingosine, aspirin, apyrase, and/or PGI2. Epoprostenol 235-239 fibrinogen beta chain Homo sapiens 132-142 10517123-4 1999 A case of congenital afibrinogenemia is described in a patient who suffered from severe bleeding episodes in the absence of replacement therapy but developed a deep vein thrombosis with multiple pulmonary emboli after fibrinogen replacement and surgical treatment of a hip fracture, despite conventional heparin prophylaxis. Heparin 304-311 fibrinogen beta chain Homo sapiens 22-32 11721406-6 1999 CONCLUSION: The anti-CD9 McAbs, HI117 and SJ9A4, can reversibly expose platelet Fg receptors, probably via three signaling pathways, i.e. thromboxane, secreted ADP and cAMP, protein kinase C (PKC) activation presumably being the common passage for the signaling. Adenosine Diphosphate 160-163 fibrinogen beta chain Homo sapiens 80-82 11721406-4 1999 But in the absence of Fg, the McAbs-exposed Fg receptors gradually lost their capacity to bind Fg and closed. Antibodies, Monoclonal 30-35 fibrinogen beta chain Homo sapiens 44-46 11721406-5 1999 Further study indicated that HI117 and SJ9A4-induced Fg binding was reduced by pretreatment of platelets with sphingosine, aspirin, apyrase, and/or PGI2. Sphingosine 110-121 fibrinogen beta chain Homo sapiens 53-55 11721406-5 1999 Further study indicated that HI117 and SJ9A4-induced Fg binding was reduced by pretreatment of platelets with sphingosine, aspirin, apyrase, and/or PGI2. Aspirin 123-130 fibrinogen beta chain Homo sapiens 53-55 11721406-5 1999 Further study indicated that HI117 and SJ9A4-induced Fg binding was reduced by pretreatment of platelets with sphingosine, aspirin, apyrase, and/or PGI2. Epoprostenol 148-152 fibrinogen beta chain Homo sapiens 53-55 11721406-6 1999 CONCLUSION: The anti-CD9 McAbs, HI117 and SJ9A4, can reversibly expose platelet Fg receptors, probably via three signaling pathways, i.e. thromboxane, secreted ADP and cAMP, protein kinase C (PKC) activation presumably being the common passage for the signaling. Thromboxanes 138-149 fibrinogen beta chain Homo sapiens 80-82 10441471-3 1999 In transfected COS cells, the degradation of fibrinogen Bbeta and gamma chain was markedly inhibited by the proteasome inhibitors lactacystin and MG132. lactacystin 130-141 fibrinogen beta chain Homo sapiens 45-55 10441471-3 1999 In transfected COS cells, the degradation of fibrinogen Bbeta and gamma chain was markedly inhibited by the proteasome inhibitors lactacystin and MG132. benzyloxycarbonylleucyl-leucyl-leucine aldehyde 146-151 fibrinogen beta chain Homo sapiens 45-55 10441471-5 1999 In HepG2 cells, which synthesize and secrete fibrinogen, the degradation of intracellular free gamma chain was also inhibited by MG132. benzyloxycarbonylleucyl-leucyl-leucine aldehyde 129-134 fibrinogen beta chain Homo sapiens 45-55 10645034-0 1999 [The effect of monotherapy with ciprofibrate and in combination with acetylsalicylic acid on the spectrum of lipids, thromboxane and fibrinogen in patients with atherosclerosis and hyperlipoproteinemia]. ciprofibrate 32-44 fibrinogen beta chain Homo sapiens 133-143 10645034-1 1999 Ciprofibrate is one of the basic drugs used to lower risk values of lipid parameters and fibrinogen in atherosclerosis patients. ciprofibrate 0-12 fibrinogen beta chain Homo sapiens 89-99 10645034-8 1999 Ciprofibrate also significantly lowered the level of fibrinogen (-17%). ciprofibrate 0-12 fibrinogen beta chain Homo sapiens 53-63 10645034-11 1999 Ciprofibrate is an effective hypolipidemic agent, also lowering the level of fibrinogen. ciprofibrate 0-12 fibrinogen beta chain Homo sapiens 77-87 10460070-0 1999 Fenofibrate decreases plasma fibrinogen, improves lipid profile, and reduces uricemia. Fenofibrate 0-11 fibrinogen beta chain Homo sapiens 29-39 10460070-2 1999 This 2-year trial was designed to assess the effect of fenofibrate on fibrinogen and, as secondary end points, on lipid profile and uric acid in patients with dyslipidemia. Fenofibrate 55-66 fibrinogen beta chain Homo sapiens 70-80 10460070-5 1999 The effect attributable to fenofibrate was a decrease of 15% in fibrinogen, 26% in the ratio low-density lipoprotein cholesterol to high-density lipoprotein cholesterol (-20% low-density lipoprotein cholesterol, +10% high-density lipoprotein cholesterol), 34% in triglycerides (median), and 13% in uric acid (P < .0001 for all). Fenofibrate 27-38 fibrinogen beta chain Homo sapiens 64-74 10502907-7 1999 Factor VIIIc, factor VIIc, and fibrinogen, ordered by the strength of the correlation, were positively and significantly correlated with glucose, uric acid, and blood pressure levels. Glucose 137-144 fibrinogen beta chain Homo sapiens 31-41 10502907-7 1999 Factor VIIIc, factor VIIc, and fibrinogen, ordered by the strength of the correlation, were positively and significantly correlated with glucose, uric acid, and blood pressure levels. Uric Acid 146-155 fibrinogen beta chain Homo sapiens 31-41 10502907-8 1999 The associations of apolipoprotein B and cholesterol with fibrinogen (p = 0.14-0.20) were not as strong as those with factors VIIc (p = 0.28-0.37) and VIIIc (p = 0.15-0.30). Cholesterol 41-52 fibrinogen beta chain Homo sapiens 58-68 10614063-8 1999 CONCLUSIONS: The postprandial levels of glucose, triglycerides, fibrinogen, F1.2, TAT and d-dimers were lower after glibenclamide administration as compared to placebo, while the concentrations of insulin and c-peptide were higher. Glyburide 116-129 fibrinogen beta chain Homo sapiens 64-74 10426341-0 1999 Variable responses to inhibition of fibrinogen binding induced by tirofiban and eptifibatide in blood from healthy subjects. Tirofiban 66-75 fibrinogen beta chain Homo sapiens 36-46 10426341-0 1999 Variable responses to inhibition of fibrinogen binding induced by tirofiban and eptifibatide in blood from healthy subjects. Eptifibatide 80-92 fibrinogen beta chain Homo sapiens 36-46 10426341-2 1999 A lack of universal efficacy may result from interindividual variation in the inhibition of fibrinogen binding after exposure to tirofiban and eptifibatide. Tirofiban 129-138 fibrinogen beta chain Homo sapiens 92-102 10426341-2 1999 A lack of universal efficacy may result from interindividual variation in the inhibition of fibrinogen binding after exposure to tirofiban and eptifibatide. Eptifibatide 143-155 fibrinogen beta chain Homo sapiens 92-102 10426341-7 1999 In platelets activated with 1 microM ADP, clinically relevant concentrations of tirofiban caused inhibition of fibrinogen binding ranging from 17% to 88%. Adenosine Diphosphate 37-40 fibrinogen beta chain Homo sapiens 111-121 10426341-8 1999 Similarly, eptifibatide caused inhibition of fibrinogen binding ranging from 32% to 74%. Eptifibatide 11-23 fibrinogen beta chain Homo sapiens 45-55 10418796-4 1999 Platelet activation was assessed with flow cytometry in whole blood anticoagulated with corn trypsin inhibitor and incubated with fluorescein isothiocyanate conjugated fibrinogen (to define activation of glycoprotein IIb-IIIa), a phycoerythrin conjugated antibody to P-selectin (a marker of alpha-granule degranulation), and selected concentrations of adenosine diphosphate (ADP) or thrombin receptor agonist peptide. Fluorescein-5-isothiocyanate 130-156 fibrinogen beta chain Homo sapiens 168-178 10418796-5 1999 ADP-induced fibrinogen binding was found to be a low threshold activation event (40% of platelets bound fibrinogen in response to 0.2 microM ADP). Adenosine Diphosphate 0-3 fibrinogen beta chain Homo sapiens 12-22 10418796-5 1999 ADP-induced fibrinogen binding was found to be a low threshold activation event (40% of platelets bound fibrinogen in response to 0.2 microM ADP). Adenosine Diphosphate 0-3 fibrinogen beta chain Homo sapiens 104-114 10418796-5 1999 ADP-induced fibrinogen binding was found to be a low threshold activation event (40% of platelets bound fibrinogen in response to 0.2 microM ADP). Adenosine Diphosphate 141-144 fibrinogen beta chain Homo sapiens 12-22 10418796-5 1999 ADP-induced fibrinogen binding was found to be a low threshold activation event (40% of platelets bound fibrinogen in response to 0.2 microM ADP). Adenosine Diphosphate 141-144 fibrinogen beta chain Homo sapiens 104-114 10573618-8 1999 Comparing fibrinogen levels between Groups A and B, we observed lower values in heparin-treated group than in the other one (p < 0.0001), while in laparoscopic surgery there was not a significant difference between two groups of treatment. Heparin 80-87 fibrinogen beta chain Homo sapiens 10-20 10403044-1 1999 The in vitro protein-rejecting properties of PEG-coated polyalkylcyanoacrylate (PACA) nanoparticles were for the first time visualized after freeze-fracture of the nanoparticles pre-incubated with fibrinogen as a model blood protein. Polyethylene Glycols 45-48 fibrinogen beta chain Homo sapiens 197-207 10403044-1 1999 The in vitro protein-rejecting properties of PEG-coated polyalkylcyanoacrylate (PACA) nanoparticles were for the first time visualized after freeze-fracture of the nanoparticles pre-incubated with fibrinogen as a model blood protein. polyalkylcyanoacrylate 56-78 fibrinogen beta chain Homo sapiens 197-207 10403044-1 1999 The in vitro protein-rejecting properties of PEG-coated polyalkylcyanoacrylate (PACA) nanoparticles were for the first time visualized after freeze-fracture of the nanoparticles pre-incubated with fibrinogen as a model blood protein. N-propargyl caffeate amide 80-84 fibrinogen beta chain Homo sapiens 197-207 10456614-0 1999 Effect of ciprofibrate on fibrinogen synthesis in vitro on hepatoma cells and in vivo in genetically obese Zucker rats. ciprofibrate 10-22 fibrinogen beta chain Homo sapiens 26-36 10456614-2 1999 When HepG2 cells were treated simultaneously with oncostatin M or interleukin-6 and ciprofibrate (100 nmol/l), the production of fibrinogen in the conditioned media was strongly affected and a significant decrease in the mRNA levels of the fibrinogen beta chain was observed. ciprofibrate 84-96 fibrinogen beta chain Homo sapiens 129-139 10456614-2 1999 When HepG2 cells were treated simultaneously with oncostatin M or interleukin-6 and ciprofibrate (100 nmol/l), the production of fibrinogen in the conditioned media was strongly affected and a significant decrease in the mRNA levels of the fibrinogen beta chain was observed. ciprofibrate 84-96 fibrinogen beta chain Homo sapiens 240-261 10456614-3 1999 Oncostatin-M- and interleukin-6-induced fibrinogen release was inhibited in a dose-dependent manner by ciprofibrate and, to lesser extent, by bezafibrate, fenofibric acid and clofibric acid. ciprofibrate 103-115 fibrinogen beta chain Homo sapiens 40-50 10456614-3 1999 Oncostatin-M- and interleukin-6-induced fibrinogen release was inhibited in a dose-dependent manner by ciprofibrate and, to lesser extent, by bezafibrate, fenofibric acid and clofibric acid. Bezafibrate 142-153 fibrinogen beta chain Homo sapiens 40-50 10456614-3 1999 Oncostatin-M- and interleukin-6-induced fibrinogen release was inhibited in a dose-dependent manner by ciprofibrate and, to lesser extent, by bezafibrate, fenofibric acid and clofibric acid. fenofibric acid 155-170 fibrinogen beta chain Homo sapiens 40-50 10456614-3 1999 Oncostatin-M- and interleukin-6-induced fibrinogen release was inhibited in a dose-dependent manner by ciprofibrate and, to lesser extent, by bezafibrate, fenofibric acid and clofibric acid. Clofibric Acid 175-189 fibrinogen beta chain Homo sapiens 40-50 10369791-5 1999 Adrenaline infusion enhanced thrombin-induced platelet fibrinogen binding and platelet aggregability (P<0.05), and elevated thrombin-antithrombin complexes (P<0.05), whereas F1+2 and fibrinopeptide A levels were not significantly affected. Epinephrine 0-10 fibrinogen beta chain Homo sapiens 55-65 10429193-12 1999 Stirred platelets showed fibrinogen-mediated aggregation by alpha-thrombin in the presence of CaCl2 but not with EDTA, suggesting that fibrinogen crosslinking of CD9 complexes via alphaIIbbeta3 could be partially responsible for this increase. Calcium Chloride 94-99 fibrinogen beta chain Homo sapiens 25-35 10429193-12 1999 Stirred platelets showed fibrinogen-mediated aggregation by alpha-thrombin in the presence of CaCl2 but not with EDTA, suggesting that fibrinogen crosslinking of CD9 complexes via alphaIIbbeta3 could be partially responsible for this increase. Calcium Chloride 94-99 fibrinogen beta chain Homo sapiens 135-145 10411706-8 1999 In addition, the binding of radiolabeled fibrinogen to activated normal platelets and platelet aggregation in response to ADP were both decreased by fibrinogen fragments. Adenosine Diphosphate 122-125 fibrinogen beta chain Homo sapiens 41-51 10411706-8 1999 In addition, the binding of radiolabeled fibrinogen to activated normal platelets and platelet aggregation in response to ADP were both decreased by fibrinogen fragments. Adenosine Diphosphate 122-125 fibrinogen beta chain Homo sapiens 149-159 10400422-2 1999 In this study, we found that in APL patients receiving ATRA or As2O3 treatment, the improvement in hypercoagulobility and hyperfibrinolysis paralleled the correction of plasma fibrinogen level and amelioration of bleeding symptoms. Tretinoin 55-59 fibrinogen beta chain Homo sapiens 176-186 10400422-2 1999 In this study, we found that in APL patients receiving ATRA or As2O3 treatment, the improvement in hypercoagulobility and hyperfibrinolysis paralleled the correction of plasma fibrinogen level and amelioration of bleeding symptoms. Arsenic Trioxide 63-68 fibrinogen beta chain Homo sapiens 176-186 11721406-6 1999 CONCLUSION: The anti-CD9 McAbs, HI117 and SJ9A4, can reversibly expose platelet Fg receptors, probably via three signaling pathways, i.e. thromboxane, secreted ADP and cAMP, protein kinase C (PKC) activation presumably being the common passage for the signaling. Cyclic AMP 168-172 fibrinogen beta chain Homo sapiens 80-82 10484747-2 1999 They can cleave the human fibrinogen to release the fibrinopeptide A and fibrinopeptide B with specific activity of 120 and 370 NIH units/mg, respectively; the fibrinogen-clotting activity can be inhibited distinctly by PMSF or DFP or EDTA, but not by heparin. Phenylmethylsulfonyl Fluoride 220-224 fibrinogen beta chain Homo sapiens 26-36 10413283-1 1999 BACKGROUND: The effect of virus inactivation of fresh plasma with methylene blue has been studied on the factor VIII/von Willebrand factor molecular complex (FVIII/vWF), factor XIII, and fibrinogen. Methylene Blue 66-80 fibrinogen beta chain Homo sapiens 187-197 10413283-6 1999 CONCLUSION: Methylene blue-treated plasma and the cryoprecipitates obtained from it may be effective for replacement therapy in cases of von Willebrand disease and deficiencies of factor XIII and fibrinogen, but the clinical studies are needed to verify that possibility. Methylene Blue 12-26 fibrinogen beta chain Homo sapiens 196-206 10484747-2 1999 They can cleave the human fibrinogen to release the fibrinopeptide A and fibrinopeptide B with specific activity of 120 and 370 NIH units/mg, respectively; the fibrinogen-clotting activity can be inhibited distinctly by PMSF or DFP or EDTA, but not by heparin. Phenylmethylsulfonyl Fluoride 220-224 fibrinogen beta chain Homo sapiens 160-170 10484747-2 1999 They can cleave the human fibrinogen to release the fibrinopeptide A and fibrinopeptide B with specific activity of 120 and 370 NIH units/mg, respectively; the fibrinogen-clotting activity can be inhibited distinctly by PMSF or DFP or EDTA, but not by heparin. Isoflurophate 228-231 fibrinogen beta chain Homo sapiens 26-36 10484747-2 1999 They can cleave the human fibrinogen to release the fibrinopeptide A and fibrinopeptide B with specific activity of 120 and 370 NIH units/mg, respectively; the fibrinogen-clotting activity can be inhibited distinctly by PMSF or DFP or EDTA, but not by heparin. Isoflurophate 228-231 fibrinogen beta chain Homo sapiens 160-170 10484747-2 1999 They can cleave the human fibrinogen to release the fibrinopeptide A and fibrinopeptide B with specific activity of 120 and 370 NIH units/mg, respectively; the fibrinogen-clotting activity can be inhibited distinctly by PMSF or DFP or EDTA, but not by heparin. Edetic Acid 235-239 fibrinogen beta chain Homo sapiens 26-36 10484747-2 1999 They can cleave the human fibrinogen to release the fibrinopeptide A and fibrinopeptide B with specific activity of 120 and 370 NIH units/mg, respectively; the fibrinogen-clotting activity can be inhibited distinctly by PMSF or DFP or EDTA, but not by heparin. Edetic Acid 235-239 fibrinogen beta chain Homo sapiens 160-170 10484747-2 1999 They can cleave the human fibrinogen to release the fibrinopeptide A and fibrinopeptide B with specific activity of 120 and 370 NIH units/mg, respectively; the fibrinogen-clotting activity can be inhibited distinctly by PMSF or DFP or EDTA, but not by heparin. Heparin 252-259 fibrinogen beta chain Homo sapiens 26-36 10484747-2 1999 They can cleave the human fibrinogen to release the fibrinopeptide A and fibrinopeptide B with specific activity of 120 and 370 NIH units/mg, respectively; the fibrinogen-clotting activity can be inhibited distinctly by PMSF or DFP or EDTA, but not by heparin. Heparin 252-259 fibrinogen beta chain Homo sapiens 160-170 10410975-8 1999 However, when granulocytes were stimulated by Mn2+ in combination with PMA, eosinophils and neutrophils showed different patterns of response to plasma fibronectin and fibrinogen, respectively, but the same pattern of response to tissue fibronectin. Manganese(2+) 46-50 fibrinogen beta chain Homo sapiens 168-178 10410975-4 1999 Using this assay, Mn2+ induced a significant increase of the adhesion of eosinophils to plasma fibronectin and fibrinogen in a time-dependent fashion, while a small increase of the adhesion of neutrophils to these two proteins was observed. Manganese(2+) 18-22 fibrinogen beta chain Homo sapiens 111-121 10329783-4 1999 The protease has arginine-esterase activity and hydrolyzes synthetic substrates such as p-toluenesulfonyl arginine methyl ester and alpha-N-benzoyl-L-arginine amide ethyl ester, and shows clotting activity with human fibrinogen, rabbit citrated plasma and human citrated plasma in vitro. p-toluenesulfonyl arginine methyl ester 88-127 fibrinogen beta chain Homo sapiens 217-227 10359776-1 1999 Atomic force microscopy in a force-spectroscopy mode has been used to investigate the kinetics of the adsorption process of fibrinogen molecules on a silica surface. Silicon Dioxide 150-156 fibrinogen beta chain Homo sapiens 124-134 10359776-3 1999 Fibrinogen molecules were adsorbed on the atomic force microscopy tip and were brought into contact with the silica surface for different interaction times varying from 5 to 2,000 ms. Silicon Dioxide 109-115 fibrinogen beta chain Homo sapiens 0-10 10359776-6 1999 The minimal interaction time for a fibrinogen molecule to bind strongly to a silica surface during an adsorption process appears to lie between 50 and 200 ms. Silicon Dioxide 77-83 fibrinogen beta chain Homo sapiens 35-45 16801092-6 1999 Flow cytometric study of platelets was undertaken utilizing fluorescein isothiocyanate (FITC)-labelled anti-human fibrinogen antibody in unstimulated and ADP-stimulated (final concentration 0.02 M) platelets. Fluorescein-5-isothiocyanate 60-86 fibrinogen beta chain Homo sapiens 114-124 16801092-6 1999 Flow cytometric study of platelets was undertaken utilizing fluorescein isothiocyanate (FITC)-labelled anti-human fibrinogen antibody in unstimulated and ADP-stimulated (final concentration 0.02 M) platelets. Fluorescein-5-isothiocyanate 88-92 fibrinogen beta chain Homo sapiens 114-124 10329783-4 1999 The protease has arginine-esterase activity and hydrolyzes synthetic substrates such as p-toluenesulfonyl arginine methyl ester and alpha-N-benzoyl-L-arginine amide ethyl ester, and shows clotting activity with human fibrinogen, rabbit citrated plasma and human citrated plasma in vitro. alpha-n-benzoyl-l-arginine amide ethyl ester 132-176 fibrinogen beta chain Homo sapiens 217-227 10357321-7 1999 Compared with the control group, magnesium prolonged the in vitro bleeding time (22%) and inhibited ADP- and collagen-induced platelet aggregation (13% and 17%), platelet P-selectin expression (18%), and the binding of fibrinogen to the platelet glycoprotein IIb/IIIa receptor (10%). Magnesium 33-42 fibrinogen beta chain Homo sapiens 219-229 10357321-8 1999 Magnesium also led to significant dose-dependent inhibition of platelet aggregation (19%), P-selectin expression (14%), and fibrinogen binding (11%) before and after surgery in vitro. Magnesium 0-9 fibrinogen beta chain Homo sapiens 124-134 10328894-0 1999 Conformational Changes of Fibrinogen Adsorption onto Hydroxyapatite and Titanium Oxide Nanoparticles. Durapatite 53-67 fibrinogen beta chain Homo sapiens 26-36 10402106-5 1999 There was a significant reduction in plasma fibrinogen levels (36.4 and 13.5% in the ciprofibrate and bezafibrate group, respectively). ciprofibrate 85-97 fibrinogen beta chain Homo sapiens 44-54 10402106-5 1999 There was a significant reduction in plasma fibrinogen levels (36.4 and 13.5% in the ciprofibrate and bezafibrate group, respectively). Bezafibrate 102-113 fibrinogen beta chain Homo sapiens 44-54 10328894-0 1999 Conformational Changes of Fibrinogen Adsorption onto Hydroxyapatite and Titanium Oxide Nanoparticles. titanium dioxide 72-86 fibrinogen beta chain Homo sapiens 26-36 10328894-2 1999 The structure of fibrinogen, a major plasma protein, adsorbed onto TiO2 and HA was examined by employing differential scanning calorimetry (DSC), circular dichroism (CD), and fluorescence spectroscopy. titanium dioxide 67-71 fibrinogen beta chain Homo sapiens 17-27 10328894-3 1999 It was found that the TiO2 surface slightly decreased the ordered secondary structure of the protein; the fibrinogen conformation further changed upo washing and desorption. titanium dioxide 22-26 fibrinogen beta chain Homo sapiens 106-116 10328894-8 1999 These results, combined with the DSC thermograms of fibrinogen at different ionic strengths, suggest that electrostatic interactions are the main mechanism controlling the adsorption of fibrinogen to TiO2 and HA. titanium dioxide 200-204 fibrinogen beta chain Homo sapiens 52-62 10328894-8 1999 These results, combined with the DSC thermograms of fibrinogen at different ionic strengths, suggest that electrostatic interactions are the main mechanism controlling the adsorption of fibrinogen to TiO2 and HA. titanium dioxide 200-204 fibrinogen beta chain Homo sapiens 186-196 10216093-2 1999 Here, we demonstrate that Zn2+ can induce the adhesion of myelomonocytic cells to the endothelium, as well as to the provisional matrix proteins vitronectin (VN) and fibrinogen (FBG), which are pivotal steps for the recruitment of leukocytes into inflamed/injured tissue. Zinc 26-30 fibrinogen beta chain Homo sapiens 166-176 10383019-0 1999 Altered flow properties of blood and increased plasma fibrinogen in cyclosporin-treated renal allograft recipients. Cyclosporine 68-79 fibrinogen beta chain Homo sapiens 54-64 10330391-6 1999 The glycoprotein IIb/IIIa (GP IIb/IIIa) inhibitors abciximab and eptifibatide (Integrilin) inhibited the binding to fibrinogen and fibronectin but had minimal effect on binding to collagen. Eptifibatide 65-77 fibrinogen beta chain Homo sapiens 116-126 10330391-6 1999 The glycoprotein IIb/IIIa (GP IIb/IIIa) inhibitors abciximab and eptifibatide (Integrilin) inhibited the binding to fibrinogen and fibronectin but had minimal effect on binding to collagen. Eptifibatide 79-89 fibrinogen beta chain Homo sapiens 116-126 10563030-2 1999 This association has several biologically plausible mechanisms with dose-dependent effects of alcohol to increase HDL cholesterol, lower plasma fibrinogen and inhibit platelet aggregation. Alcohols 94-101 fibrinogen beta chain Homo sapiens 144-154 10346888-5 1999 All of the dextran sulfates were desorbed from its surface, while about 30% of the poly(GEMA) sulfate remained on the immobilized fibrinogen upon the addition of NaCl to the buffer which was done in order to analyze the desorption of poly(GEMA) sulfate or dextran sulfate from the surface of the fibrinogen. Sodium Chloride 162-166 fibrinogen beta chain Homo sapiens 130-140 10216095-6 1999 The suppression of fibrinogen expression was dose-dependent and was already evident after 1 day at the highest dose of fenofibrate tested (0.5% [wt/wt]). Fenofibrate 119-130 fibrinogen beta chain Homo sapiens 19-29 10216095-7 1999 Nuclear run-on experiments showed that the decrease in fibrinogen expression after fenofibrate occurred at the transcriptional level, as exemplified for the gene for the Aalpha-chain. Fenofibrate 83-94 fibrinogen beta chain Homo sapiens 55-65 10346888-5 1999 All of the dextran sulfates were desorbed from its surface, while about 30% of the poly(GEMA) sulfate remained on the immobilized fibrinogen upon the addition of NaCl to the buffer which was done in order to analyze the desorption of poly(GEMA) sulfate or dextran sulfate from the surface of the fibrinogen. Sodium Chloride 162-166 fibrinogen beta chain Homo sapiens 296-306 10346888-6 1999 These data show that the type of binding between fibrinogen-poly(GEMA) sulfate was different from that of dextran sulfate, indicating that the interaction between fibrinogen and poly(GEMA) sulfate was caused not only by an electrostatic but also by a hydrophobic force. poly(glucosyloxyethyl methacrylate) sulfate 60-78 fibrinogen beta chain Homo sapiens 49-59 10216095-9 1999 The effect of fibrates is specific for peroxisome proliferator-activated receptor-alpha (PPARalpha) because a high-affinity ligand for PPARgamma, the thiazolidinedione BRL 49653, lowered triglyceride levels, but was unable to suppress fibrinogen expression. 2,4-thiazolidinedione 150-167 fibrinogen beta chain Homo sapiens 235-245 10216095-9 1999 The effect of fibrates is specific for peroxisome proliferator-activated receptor-alpha (PPARalpha) because a high-affinity ligand for PPARgamma, the thiazolidinedione BRL 49653, lowered triglyceride levels, but was unable to suppress fibrinogen expression. Triglycerides 187-199 fibrinogen beta chain Homo sapiens 235-245 10216095-13 1999 On treatment with 0.2% (wt/wt) fenofibrate, a significant decrease in plasma fibrinogen to 77% +/- 10% of control levels and in hepatic fibrinogen Aalpha-chain mRNA levels to 65% +/- 12% of control levels was seen in (+/+) mice, but not in (-/-) mice. Fenofibrate 31-42 fibrinogen beta chain Homo sapiens 77-87 10216095-13 1999 On treatment with 0.2% (wt/wt) fenofibrate, a significant decrease in plasma fibrinogen to 77% +/- 10% of control levels and in hepatic fibrinogen Aalpha-chain mRNA levels to 65% +/- 12% of control levels was seen in (+/+) mice, but not in (-/-) mice. Fenofibrate 31-42 fibrinogen beta chain Homo sapiens 136-146 10346888-6 1999 These data show that the type of binding between fibrinogen-poly(GEMA) sulfate was different from that of dextran sulfate, indicating that the interaction between fibrinogen and poly(GEMA) sulfate was caused not only by an electrostatic but also by a hydrophobic force. poly(glucosyloxyethyl methacrylate) sulfate 60-78 fibrinogen beta chain Homo sapiens 163-173 10346888-6 1999 These data show that the type of binding between fibrinogen-poly(GEMA) sulfate was different from that of dextran sulfate, indicating that the interaction between fibrinogen and poly(GEMA) sulfate was caused not only by an electrostatic but also by a hydrophobic force. Dextran Sulfate 106-121 fibrinogen beta chain Homo sapiens 163-173 10346888-6 1999 These data show that the type of binding between fibrinogen-poly(GEMA) sulfate was different from that of dextran sulfate, indicating that the interaction between fibrinogen and poly(GEMA) sulfate was caused not only by an electrostatic but also by a hydrophobic force. poly(glucosyloxyethyl methacrylate) sulfate 178-196 fibrinogen beta chain Homo sapiens 49-59 10346888-6 1999 These data show that the type of binding between fibrinogen-poly(GEMA) sulfate was different from that of dextran sulfate, indicating that the interaction between fibrinogen and poly(GEMA) sulfate was caused not only by an electrostatic but also by a hydrophobic force. poly(glucosyloxyethyl methacrylate) sulfate 178-196 fibrinogen beta chain Homo sapiens 163-173 10346888-7 1999 These results suggest that the interaction mechanism of heparinoids with fibrinogen was different from that of heparin. Heparin 56-63 fibrinogen beta chain Homo sapiens 73-83 10329065-0 1999 Increased binding of fibrinogen to glycoprotein IIIa-proline33 (HPA-1b, PlA2, Zwb) positive platelets in patients with cardiovascular disease. proline33 53-62 fibrinogen beta chain Homo sapiens 21-31 10342343-8 1999 In the pravastatin-treated group (11 patients), fibrinogen decreased significantly, FI reached a normal value (<10) in six patients. Pravastatin 7-18 fibrinogen beta chain Homo sapiens 48-58 10344682-1 1999 PURPOSE: Our goal was to determine if autologous fibrin tissue adhesive derived from the precipitation of fibrinogen using a combination of ethanol and freezing, could be used to completely close both simple and complex fistulas-in-ano. Ethanol 140-147 fibrinogen beta chain Homo sapiens 106-116 10329065-7 1999 Fibrinogen binding to ADP-stimulated platelets was significantly higher in the GPIIIa-Pro33 positive group at all ADP concentrations (<0.0001; two way ANOVA). Adenosine Diphosphate 22-25 fibrinogen beta chain Homo sapiens 0-10 10329065-7 1999 Fibrinogen binding to ADP-stimulated platelets was significantly higher in the GPIIIa-Pro33 positive group at all ADP concentrations (<0.0001; two way ANOVA). Adenosine Diphosphate 114-117 fibrinogen beta chain Homo sapiens 0-10 10217377-0 1999 More on the effect of atorvastatin on plasma fibrinogen levels in primary hypercholesterolemia. Atorvastatin 22-34 fibrinogen beta chain Homo sapiens 45-55 10376852-8 1999 Fibrinogen, an independent cardiovascular risk factor, increased after placebo (+35.0 mg/dl) and decreased after treatment with moexipril (-33.6 mg/dl), the difference, however, was not statistically significant. moexipril 128-137 fibrinogen beta chain Homo sapiens 0-10 10365751-0 1999 Fibrinogen Matsumoto III: a variant with gamma275 Arg-->Cys (CGC-->TGC)--comparison of fibrin polymerization properties with those of Matsumoto I (gamma364 Asp-->His) and Matsumoto II (gamma308 Asn-->Lys). Cysteine 59-62 fibrinogen beta chain Homo sapiens 0-10 10207014-4 1999 Incubation of Raji with Fg resulted in the increased tyrosine phosphorylation of the receptor-associated tyrosine kinase, pp60(Src) and extracellular signal-regulated kinase-1 (ERK). Tyrosine 53-61 fibrinogen beta chain Homo sapiens 24-26 10207014-6 1999 100 microM amounts of Fg peptide gamma-(117-133) caused an increase in tyrosine phosphorylation of ERK-1. Tyrosine 71-79 fibrinogen beta chain Homo sapiens 22-24 10086317-2 1999 ADP induces platelet shape change, exposure of fibrinogen binding sites, aggregation, and influx and intracellular mobilization of Ca2+. Adenosine Diphosphate 0-3 fibrinogen beta chain Homo sapiens 47-57 10195914-0 1999 Fibrinogen: a possible link between alcohol consumption and cardiovascular disease? Alcohols 36-43 fibrinogen beta chain Homo sapiens 0-10 10195914-2 1999 The relation between alcohol consumption and fibrinogen concentration was evaluated in a French population to investigate whether fibrinogen could explain part of the relation between alcohol consumption and cardiovascular disease. Alcohols 21-28 fibrinogen beta chain Homo sapiens 45-55 10195914-5 1999 Alcohol consumption was strongly associated with fibrinogen concentration, with higher concentrations in those who were nondrinkers or who drank >60 g of alcohol per day. Alcohols 0-7 fibrinogen beta chain Homo sapiens 49-59 10195914-5 1999 Alcohol consumption was strongly associated with fibrinogen concentration, with higher concentrations in those who were nondrinkers or who drank >60 g of alcohol per day. Alcohols 157-164 fibrinogen beta chain Homo sapiens 49-59 10195914-10 1999 If fibrinogen is a causal risk factor for cardiovascular disease, it may be 1 of the variables that explain the protective effect of moderate alcohol consumption on cardiovascular disease. Alcohols 142-149 fibrinogen beta chain Homo sapiens 3-13 10357007-0 1999 Increasing plasma fibrinogen, but unchanged levels of intraplatelet cyclic nucleotides, plasma endothelin-1, factor VII, and neopterin during cholesterol lowering with fluvastatin. Fluvastatin 168-179 fibrinogen beta chain Homo sapiens 18-28 10357007-7 1999 In conclusion, during cholesterol-lowering treatment with fluvastatin, plasma levels of fibrinogen increased whereas intraplatelet cyclic nucleotide levels and plasma endothelin-1, factor VII and neopterin levels were unchanged. Fluvastatin 58-69 fibrinogen beta chain Homo sapiens 88-98 10193737-10 1999 CONCLUSIONS: Among these apparently healthy U.S. male physicians, fibrinogen is associated with increased risk of future MI independent of other coronary risk factors, atherogenic factors such as lipids and antithrombotics such as aspirin. Aspirin 231-238 fibrinogen beta chain Homo sapiens 66-76 10213272-0 1999 Src-family kinase-p53/ Lyn p56 plays an important role in TNF-alpha-stimulated production of O2- by human neutrophils adherent to fibrinogen. Superoxides 93-95 fibrinogen beta chain Homo sapiens 130-140 10213272-5 1999 Our results demonstrated that, in neutrophils adherent to fibrinogen, PP1 inhibited TNFalpha-stimulated superoxide production and protein tyrosine phosphorylation in a dose-dependent manner. Superoxides 104-114 fibrinogen beta chain Homo sapiens 58-68 10213272-5 1999 Our results demonstrated that, in neutrophils adherent to fibrinogen, PP1 inhibited TNFalpha-stimulated superoxide production and protein tyrosine phosphorylation in a dose-dependent manner. Tyrosine 138-146 fibrinogen beta chain Homo sapiens 58-68 10353071-7 1999 However, micronized fenofibrate could significantly decrease plasma fibrinogen levels, whereas atorvastatin evoked a small increase. Fenofibrate 20-31 fibrinogen beta chain Homo sapiens 68-78 10397958-0 1999 Fibrinogen adsorbs from aqueous media to microscopic droplets of poly(dimethylsiloxane) and remains coagulable. poly 65-69 fibrinogen beta chain Homo sapiens 0-10 10397958-0 1999 Fibrinogen adsorbs from aqueous media to microscopic droplets of poly(dimethylsiloxane) and remains coagulable. Dimethylpolysiloxanes 70-86 fibrinogen beta chain Homo sapiens 0-10 10397958-1 1999 Fibrinogen binds from aqueous media containing it to droplets of linear trimethylsilyl-terminated poly(dimethylsiloxane) (PDMS) dispersed in those same media. trimethylsilyl-terminated poly(dimethylsiloxane) 72-120 fibrinogen beta chain Homo sapiens 0-10 10397958-4 1999 Thus fibrinogen bound to droplets of PDMS renders an adhesive potential to the surface of the droplets, a potential that may have relevance to the biologic processing of the polymer in vivo. Polymers 174-181 fibrinogen beta chain Homo sapiens 5-15 10397927-3 1999 The purpose of this study was to investigate time-dependent functional changes in fibrinogen adsorbed to polytetrafluoroethylene (PTFE), polyethylene (PE), and silicone rubber (SR). Polytetrafluoroethylene 105-128 fibrinogen beta chain Homo sapiens 82-92 10235450-2 1999 Platelet adhesion to fibrinogen resulted in a partial conversion of the faster to the slower migrating (phosphorylated) form of Ca(+2)-sensitive cytosolic phospholipase A2(cPLA2) but failed to trigger arachidonic acid (AA) release. Arachidonic Acid 201-217 fibrinogen beta chain Homo sapiens 21-31 10093966-19 1999 It is evident that pectin or acetate supplementation can be useful during the treatment or prevention of some clinical manifestations, especially those associated with raised total cholesterol and possibly also plasma fibrinogen. Acetates 29-36 fibrinogen beta chain Homo sapiens 218-228 10397927-3 1999 The purpose of this study was to investigate time-dependent functional changes in fibrinogen adsorbed to polytetrafluoroethylene (PTFE), polyethylene (PE), and silicone rubber (SR). Polytetrafluoroethylene 130-134 fibrinogen beta chain Homo sapiens 82-92 10397927-3 1999 The purpose of this study was to investigate time-dependent functional changes in fibrinogen adsorbed to polytetrafluoroethylene (PTFE), polyethylene (PE), and silicone rubber (SR). Polyethylene 137-149 fibrinogen beta chain Homo sapiens 82-92 10397927-3 1999 The purpose of this study was to investigate time-dependent functional changes in fibrinogen adsorbed to polytetrafluoroethylene (PTFE), polyethylene (PE), and silicone rubber (SR). Polyethylene 151-153 fibrinogen beta chain Homo sapiens 82-92 10397927-3 1999 The purpose of this study was to investigate time-dependent functional changes in fibrinogen adsorbed to polytetrafluoroethylene (PTFE), polyethylene (PE), and silicone rubber (SR). Silicone Elastomers 160-175 fibrinogen beta chain Homo sapiens 82-92 10397927-3 1999 The purpose of this study was to investigate time-dependent functional changes in fibrinogen adsorbed to polytetrafluoroethylene (PTFE), polyethylene (PE), and silicone rubber (SR). Silicone Elastomers 177-179 fibrinogen beta chain Homo sapiens 82-92 10397927-5 1999 Changes in fibrinogen reactivity were determined by measuring the adhesion of 51Cr-labeled platelets, the binding of a monoclonal antibody (mAb) directed against an important functional region of the fibrinogen molecule (the gamma-chain dodecapeptide sequence 400-411), and the ability of blood plasma to displace previously adsorbed fibrinogen. Chromium-51 78-82 fibrinogen beta chain Homo sapiens 11-21 10397927-8 1999 When using PTFE and SR as substrates, mAb recognition of adsorbed fibrinogen did not change with residence time whereas that on PE decreased slightly. Polytetrafluoroethylene 11-15 fibrinogen beta chain Homo sapiens 66-76 10397927-8 1999 When using PTFE and SR as substrates, mAb recognition of adsorbed fibrinogen did not change with residence time whereas that on PE decreased slightly. Silicone Elastomers 20-22 fibrinogen beta chain Homo sapiens 66-76 10050049-3 1999 Thrombin, as determined both using a chromogenic substrate and the natural substrate, fibrinogen, was inactivated upon reaction with CS in a dose-dependent manner, but not in the presence of the structurally related steroid sulfates, I3SO3-GalCer and II3NAalpha-LacCer, suggesting that both the sulfate group and the hydrophobic side chain of CS are necessary for the inhibitory activity of CS. cholesteryl sulfate 133-135 fibrinogen beta chain Homo sapiens 86-96 10193692-2 1999 By preventing fibrinogen binding to the GP IIb/IIIa receptor, eptifibatide inhibits platelet aggregation and prevents thrombus formation. Eptifibatide 62-74 fibrinogen beta chain Homo sapiens 14-24 10050049-3 1999 Thrombin, as determined both using a chromogenic substrate and the natural substrate, fibrinogen, was inactivated upon reaction with CS in a dose-dependent manner, but not in the presence of the structurally related steroid sulfates, I3SO3-GalCer and II3NAalpha-LacCer, suggesting that both the sulfate group and the hydrophobic side chain of CS are necessary for the inhibitory activity of CS. ii3naalpha-laccer 251-268 fibrinogen beta chain Homo sapiens 86-96 10082776-7 1999 Turpentine injection decreased muscle FSR but increased the FSR, ASR and plasma concentrations of both albumin and fibrinogen in control piglets. Turpentine 0-10 fibrinogen beta chain Homo sapiens 115-125 10048412-2 1999 The adsorption from blood plasma solutions of albumin, fibrinogen and immunoglobulin-G (IgG), to a polystyrene surface was investigated as part of concentration- and time-dependent studies, to observe the sequential adsorption of the three proteins at the surface. Polystyrenes 99-110 fibrinogen beta chain Homo sapiens 55-65 10346888-1 1999 We analyzed the binding of heparinoid or heparin with fibrinogen by real-time measurement using surface plasmon resonance technology. Heparinoids 27-37 fibrinogen beta chain Homo sapiens 54-64 10346888-1 1999 We analyzed the binding of heparinoid or heparin with fibrinogen by real-time measurement using surface plasmon resonance technology. Heparin 27-34 fibrinogen beta chain Homo sapiens 54-64 10346888-3 1999 The binding ability of each sulfated polymer was estimated by having each polymer-containing buffer interact with the sensor chip surfaces that had immobilized fibrinogen. Polymers 37-44 fibrinogen beta chain Homo sapiens 160-170 10346888-4 1999 Dextran sulfate and poly(GEMA) sulfate showed high affinity to the fibrinogen in this experiment, while the heparin did not. Dextran Sulfate 0-15 fibrinogen beta chain Homo sapiens 67-77 10346888-4 1999 Dextran sulfate and poly(GEMA) sulfate showed high affinity to the fibrinogen in this experiment, while the heparin did not. poly(glucosyloxyethyl methacrylate) sulfate 20-38 fibrinogen beta chain Homo sapiens 67-77 10346888-5 1999 All of the dextran sulfates were desorbed from its surface, while about 30% of the poly(GEMA) sulfate remained on the immobilized fibrinogen upon the addition of NaCl to the buffer which was done in order to analyze the desorption of poly(GEMA) sulfate or dextran sulfate from the surface of the fibrinogen. poly(glucosyloxyethyl methacrylate) sulfate 83-101 fibrinogen beta chain Homo sapiens 130-140 10064272-3 1999 These modified hirutonins inhibited the amidolytic activity of alpha-thrombin (Ki approximately 35 nM), prevented fibrinogen clotting (dTT approximately 100 nM) and inhibited human platelet aggregation and 5-hydroxytryptamine secretion induced by alpha-thrombin (IC50 approximately 600 nM). hirutonins 15-25 fibrinogen beta chain Homo sapiens 114-124 9974403-9 1999 Inhibition of protein kinase C (bisindolylmaleimide) diminished fibrinogen binding and sensitization by LDL; inhibition of tyrosine kinases (herbimycin A) left fibrinogen binding unchanged but diminished sensitization by LDL. bisindolylmaleimide 32-51 fibrinogen beta chain Homo sapiens 64-74 10397913-0 1999 Human plasma fibrinogen adsorption and platelet adhesion to polystyrene. Polystyrenes 60-71 fibrinogen beta chain Homo sapiens 13-23 10397913-6 1999 Fibrinogen adsorption from afibrinogenemic plasma to polystyrene (Immulon I(R)) was low and <10 ng/cm2. Polystyrenes 53-64 fibrinogen beta chain Homo sapiens 0-10 10397913-8 1999 Platelet adhesion was restored on polystyrene preadsorbed with fibrinogen-replenished afibrinogenemic plasma. Polystyrenes 34-45 fibrinogen beta chain Homo sapiens 63-73 10397913-12 1999 Platelet adhesion to polystyrene preadsorbed with blood plasma thus appears to be a strongly bivariate function of adsorbed fibrinogen, responsive to both low amounts and altered states of the adsorbed molecule. Polystyrenes 21-32 fibrinogen beta chain Homo sapiens 124-134 11563401-8 1999 Pravastatin is the only agent proven to significantly reduce platelet-thrombus formation and fibrinogen levels. Pravastatin 0-11 fibrinogen beta chain Homo sapiens 93-103 11563401-9 1999 Simvastatin has no effect on platelet-thrombus formation or fibrinogen levels, while atorvastatin and lovastatin have been shown to increase fibrinogen in some studies. Atorvastatin 85-97 fibrinogen beta chain Homo sapiens 141-151 11563401-9 1999 Simvastatin has no effect on platelet-thrombus formation or fibrinogen levels, while atorvastatin and lovastatin have been shown to increase fibrinogen in some studies. Lovastatin 102-112 fibrinogen beta chain Homo sapiens 141-151 10064005-4 1999 Polymerization of fibrin monomers derived from purified fibrinogen was delayed in the presence of either calcium or EDTA. Calcium 105-112 fibrinogen beta chain Homo sapiens 56-66 10064005-4 1999 Polymerization of fibrin monomers derived from purified fibrinogen was delayed in the presence of either calcium or EDTA. Edetic Acid 116-120 fibrinogen beta chain Homo sapiens 56-66 10064005-8 1999 In the presence of 10 mM EDTA, the conversion of variant fragment D1 to D2 was accelerated whereas the degradation of fragment D2 to D3 was delayed in comparison to degradation of fragments D1 and D2 of normal fibrinogen. Edetic Acid 25-29 fibrinogen beta chain Homo sapiens 210-220 10064005-9 1999 Three high-affinity calcium binding sites were found in both normal and variant fibrinogen. Calcium 20-27 fibrinogen beta chain Homo sapiens 80-90 10436304-5 1999 A PT test supplemented with bovine plasma fibrinogen (Thrombotest) revealed lower fibrinogen-independent international normalized ratio (INR) values in the proposita on oral anticoagulation compared to a control group with eufibrinogenemia. proposita 156-165 fibrinogen beta chain Homo sapiens 42-52 10436304-5 1999 A PT test supplemented with bovine plasma fibrinogen (Thrombotest) revealed lower fibrinogen-independent international normalized ratio (INR) values in the proposita on oral anticoagulation compared to a control group with eufibrinogenemia. proposita 156-165 fibrinogen beta chain Homo sapiens 82-92 10494346-0 1999 Heparin-mediated extracorporeal LDL/fibrinogen precipitation--H.E.L.P.--in coronary and cerebral ischemia. Heparin 0-7 fibrinogen beta chain Homo sapiens 36-46 10494346-3 1999 To maintain this supply, H.E.L.P.-apheresis (Heparin-mediated Extracorporeal LDL/Fibrinogen Precipitation) has already proven beneficial in the prevention and therapy of myocardial infarction. Heparin 45-52 fibrinogen beta chain Homo sapiens 81-91 9950176-10 1999 However, only polysulfone induced an increase in CD11b expression and fibrinogen binding to monocytes. polysulfone P 1700 14-25 fibrinogen beta chain Homo sapiens 70-80 9950185-9 1999 In this case, particular nanoparticles functionalized with aliphatic diamines bound significantly higher amounts of fibrinogen than all other ligands. Diamines 69-77 fibrinogen beta chain Homo sapiens 116-126 9950187-2 1999 Plasticized polyvinyl chloride before and after treatment with methanol to reduce the plasticizer surface level was assessed in terms of fibrinogen and albumin adsorption with unplasticized polyvinyl chloride acting as a control. Polyvinyl Chloride 12-30 fibrinogen beta chain Homo sapiens 137-147 9950187-2 1999 Plasticized polyvinyl chloride before and after treatment with methanol to reduce the plasticizer surface level was assessed in terms of fibrinogen and albumin adsorption with unplasticized polyvinyl chloride acting as a control. Methanol 63-71 fibrinogen beta chain Homo sapiens 137-147 10050049-3 1999 Thrombin, as determined both using a chromogenic substrate and the natural substrate, fibrinogen, was inactivated upon reaction with CS in a dose-dependent manner, but not in the presence of the structurally related steroid sulfates, I3SO3-GalCer and II3NAalpha-LacCer, suggesting that both the sulfate group and the hydrophobic side chain of CS are necessary for the inhibitory activity of CS. cholesteryl sulfate 343-345 fibrinogen beta chain Homo sapiens 86-96 10050049-3 1999 Thrombin, as determined both using a chromogenic substrate and the natural substrate, fibrinogen, was inactivated upon reaction with CS in a dose-dependent manner, but not in the presence of the structurally related steroid sulfates, I3SO3-GalCer and II3NAalpha-LacCer, suggesting that both the sulfate group and the hydrophobic side chain of CS are necessary for the inhibitory activity of CS. cholesteryl sulfate 343-345 fibrinogen beta chain Homo sapiens 86-96 27426845-6 1999 After a week with ATRA treatment, fibrinogen level improved and "D" dimers decreased, so as observed slowly maturation of leukemic leucocytes. Tretinoin 18-22 fibrinogen beta chain Homo sapiens 34-44 10836317-9 1999 Treatment with prednisone suppressed median sputum eosinophilia (from 16.3 to 0%, p<0.001), decreased sputum ECP (from 7,480 to 700 microg x L(-1), p = 0.01), but did not improve neutrophil numbers, fibrinogen or IL-5. Prednisone 15-25 fibrinogen beta chain Homo sapiens 202-212 10702704-0 1999 Determination of the prevalence of fibrinogen Banks peninsula mutation (gamma280Tyr-->Cys) by PCR. Cysteine 89-92 fibrinogen beta chain Homo sapiens 35-45 10702704-1 1999 A mutation of Tyr-->Cys at position 280 of the gamma chain of fibrinogen was recently determined to be the cause for fibrinogen Banks peninsula. Tyrosine 14-17 fibrinogen beta chain Homo sapiens 65-75 10702704-1 1999 A mutation of Tyr-->Cys at position 280 of the gamma chain of fibrinogen was recently determined to be the cause for fibrinogen Banks peninsula. Tyrosine 14-17 fibrinogen beta chain Homo sapiens 120-130 10702704-1 1999 A mutation of Tyr-->Cys at position 280 of the gamma chain of fibrinogen was recently determined to be the cause for fibrinogen Banks peninsula. Cysteine 23-26 fibrinogen beta chain Homo sapiens 65-75 10702704-1 1999 A mutation of Tyr-->Cys at position 280 of the gamma chain of fibrinogen was recently determined to be the cause for fibrinogen Banks peninsula. Cysteine 23-26 fibrinogen beta chain Homo sapiens 120-130 10098583-6 1999 PTFE, with the lowest contact angle decrease over a 500 minutes period (19 degrees), showed low fibrinogen and albumin adsorption as well as low platelet adhesion. Polytetrafluoroethylene 0-4 fibrinogen beta chain Homo sapiens 96-106 9880793-5 1999 US-1 had a typical Arg-Gly-Asp (RGD) sequence, which is responsible for blocking the binding of fibrinogen to the receptor. Arginine 19-22 fibrinogen beta chain Homo sapiens 96-106 10450539-0 1999 Etofibrate decreases factor VII and fibrinogen levels in patients with polymetabolic syndrome. etofibrate 0-10 fibrinogen beta chain Homo sapiens 36-46 9880793-5 1999 US-1 had a typical Arg-Gly-Asp (RGD) sequence, which is responsible for blocking the binding of fibrinogen to the receptor. Glycine 23-26 fibrinogen beta chain Homo sapiens 96-106 9880793-5 1999 US-1 had a typical Arg-Gly-Asp (RGD) sequence, which is responsible for blocking the binding of fibrinogen to the receptor. Aspartic Acid 27-30 fibrinogen beta chain Homo sapiens 96-106 16801120-1 1999 Recent studies have suggested that the platelet fibrinogen (Fg) receptor, platelet membrane glycoprotein IIbIIIa (GPIIbIIIa, or integrin alpha(IIb)beta(3)) is also an adenosine triphosphate (ATP) binding site, and that the binding of ATP can directly inhibit the Fg-binding function of GPIIbIIIa. Adenosine Triphosphate 167-189 fibrinogen beta chain Homo sapiens 48-58 16801120-1 1999 Recent studies have suggested that the platelet fibrinogen (Fg) receptor, platelet membrane glycoprotein IIbIIIa (GPIIbIIIa, or integrin alpha(IIb)beta(3)) is also an adenosine triphosphate (ATP) binding site, and that the binding of ATP can directly inhibit the Fg-binding function of GPIIbIIIa. Adenosine Triphosphate 191-194 fibrinogen beta chain Homo sapiens 48-58 16801120-1 1999 Recent studies have suggested that the platelet fibrinogen (Fg) receptor, platelet membrane glycoprotein IIbIIIa (GPIIbIIIa, or integrin alpha(IIb)beta(3)) is also an adenosine triphosphate (ATP) binding site, and that the binding of ATP can directly inhibit the Fg-binding function of GPIIbIIIa. Adenosine Triphosphate 234-237 fibrinogen beta chain Homo sapiens 48-58 9848889-4 1998 Lecithin preexisting on the surface of oil droplets reduces significantly the amount of fibrinogen that can otherwise bind to them. Lecithins 0-8 fibrinogen beta chain Homo sapiens 88-98 9843745-3 1998 An age-related decline in FSR of fibrinogen (P < 0.01) was observed with use of both tracers, with the maximal decrease (average 37% with alpha-[13C]ketoisocaproate as the precursor) occurring by middle age and with no further changes thereafter. alpha-[13c]ketoisocaproate 141-167 fibrinogen beta chain Homo sapiens 33-43 9848889-4 1998 Lecithin preexisting on the surface of oil droplets reduces significantly the amount of fibrinogen that can otherwise bind to them. Oils 39-42 fibrinogen beta chain Homo sapiens 88-98 9848889-6 1998 As a consequence, oil droplets coated with fibrinogen can participate in a host of biologically important adhesive processes in which the protein would be expected to participate. Oils 18-21 fibrinogen beta chain Homo sapiens 43-53 9848889-7 1998 Certain polyanions, eg, heparin, pentosan polysulfate, dextran sulfate, and suramin, bind to adsorbed fibrin(ogen) and prevent thrombin-dependent adhesion of fibrinogen-coated surfaces. polyanions 8-18 fibrinogen beta chain Homo sapiens 158-168 9848889-7 1998 Certain polyanions, eg, heparin, pentosan polysulfate, dextran sulfate, and suramin, bind to adsorbed fibrin(ogen) and prevent thrombin-dependent adhesion of fibrinogen-coated surfaces. Heparin 24-31 fibrinogen beta chain Homo sapiens 158-168 9848889-7 1998 Certain polyanions, eg, heparin, pentosan polysulfate, dextran sulfate, and suramin, bind to adsorbed fibrin(ogen) and prevent thrombin-dependent adhesion of fibrinogen-coated surfaces. Pentosan Sulfuric Polyester 33-53 fibrinogen beta chain Homo sapiens 158-168 9848889-7 1998 Certain polyanions, eg, heparin, pentosan polysulfate, dextran sulfate, and suramin, bind to adsorbed fibrin(ogen) and prevent thrombin-dependent adhesion of fibrinogen-coated surfaces. Dextran Sulfate 55-70 fibrinogen beta chain Homo sapiens 158-168 9848889-7 1998 Certain polyanions, eg, heparin, pentosan polysulfate, dextran sulfate, and suramin, bind to adsorbed fibrin(ogen) and prevent thrombin-dependent adhesion of fibrinogen-coated surfaces. Suramin 76-83 fibrinogen beta chain Homo sapiens 158-168 9817701-8 1998 In these patients, prednisone also produced a significant decline in the median sputum eosinophil percentage, from 9.7% to 0.5% (p = 0.002), eosinophil cationic protein (ECP), from 6, 000 microgram/L to 1,140 microgram/L (p < 0.001), and fibrinogen, from 25. Prednisone 19-29 fibrinogen beta chain Homo sapiens 241-251 9884053-2 1998 A cross-linked fibrin layer was formed on polyethylene which had been precoated with thermally denatured fibrinogen. Polyethylene 42-54 fibrinogen beta chain Homo sapiens 105-115 9884053-6 1998 Vroman peaks were observed for fibrinogen and fibronectin on polyethylene but not on the cross-linked fibrin and thermally denatured fibrinogen materials. Polyethylene 61-73 fibrinogen beta chain Homo sapiens 31-41 9878994-2 1998 UNLABELLED: Tirofiban is an intravenously administered nonpeptide glycoprotein IIb/IIIa receptor antagonist which specifically inhibits fibrinogen-dependent platelet aggregation and prolongs bleeding times in patients with acute coronary syndromes. Tirofiban 12-21 fibrinogen beta chain Homo sapiens 136-146 9887398-4 1998 Furthermore, we found increased levels of cholesterol, fibrinogen and plasmatic homocysteine after methionine loading. Methionine 99-109 fibrinogen beta chain Homo sapiens 55-65 10024188-4 1998 RESULTS: Fibrinogen was 12.9 mg/dl higher in men and 14.1 mg/dl higher in women in Tarnobrzeg compared to Warsaw. tarnobrzeg 83-93 fibrinogen beta chain Homo sapiens 9-19 10024188-7 1998 In women, a 15 mg/dl increase in HDL-cholesterol was associated with a 10 mg/dl decrease in fibrinogen (P < 0.01). Cholesterol 37-48 fibrinogen beta chain Homo sapiens 92-102 9924997-8 1998 Finally, a portion of the library was screened against 14C-labeled fibrinogen. Carbon-14 55-58 fibrinogen beta chain Homo sapiens 67-77 9792766-0 1998 Aggregation of HSA, IgG, and Fibrinogen on Methylated Silicon Surfaces. Silicon 54-61 fibrinogen beta chain Homo sapiens 29-39 9790811-7 1998 PMA treatment induced spreading of the FBGN bound cells. Tetradecanoylphorbol Acetate 0-3 fibrinogen beta chain Homo sapiens 39-43 10357263-9 1999 The amount of fibrinogen adsorbed on every MAPC polymer surface was reduced by addition of the DMPC liposome in the fibrinogen solution. Dimyristoylphosphatidylcholine 95-99 fibrinogen beta chain Homo sapiens 14-24 10357263-9 1999 The amount of fibrinogen adsorbed on every MAPC polymer surface was reduced by addition of the DMPC liposome in the fibrinogen solution. Dimyristoylphosphatidylcholine 95-99 fibrinogen beta chain Homo sapiens 116-126 10357263-10 1999 The number of platelets adhered on the MAPC polymer was also decreased when the DMPC liposome was present in the fibrinogen solution during pretreatment. Dimyristoylphosphatidylcholine 80-84 fibrinogen beta chain Homo sapiens 113-123 9863654-10 1998 The tetrapeptide Arg-Gly-Asp-Ser (RGDS; 20-200 microM) which inhibits von Willebrand factor, fibrinogen and fibronectin-mediated adhesion, had no effect on the promoting effect of platelets on tube formation. arginyl-glycyl-aspartyl-serine 17-32 fibrinogen beta chain Homo sapiens 93-103 9857916-10 1998 CONCLUSION: Body mass index, season, alcohol consumption and place of residence are markers of plasma lipid profile and fibrinogen in young men. Alcohols 37-44 fibrinogen beta chain Homo sapiens 120-130 10070221-7 1998 Bezafibrate lowered slightly the insulin level but did not affect peptide C. A correlation of changes in fibrinogen levels and the 60 min insulin concentration in the glucose tolerance test was higher in the bezafibrate group (r = 0.61) than in the placebo group (r = 0.23). Glucose 167-174 fibrinogen beta chain Homo sapiens 105-115 9843175-3 1998 Fibrinogen values were higher in subjects with C reactive protein (C-RP) >0.33 mg/dl, BMI >23.9 kg/m2, total cholesterol >4.84 mmol/l, triglycerides > 1.02 mmol/l, PAI-1 antigen >12.2 ng/ml, carriers of the A allele, first-degree relative history of coronary artery disease, or consuming >10 cigarettes per day (p<0.01). Cholesterol 115-126 fibrinogen beta chain Homo sapiens 0-10 9843166-6 1998 Fibrinogen level increased with age, smoking, waist-to-hip ratio, LDL-cholesterol, and it decreased with educational level, leisure physical activity, alcohol intake and HDL-cholesterol. Cholesterol 70-81 fibrinogen beta chain Homo sapiens 0-10 9843175-3 1998 Fibrinogen values were higher in subjects with C reactive protein (C-RP) >0.33 mg/dl, BMI >23.9 kg/m2, total cholesterol >4.84 mmol/l, triglycerides > 1.02 mmol/l, PAI-1 antigen >12.2 ng/ml, carriers of the A allele, first-degree relative history of coronary artery disease, or consuming >10 cigarettes per day (p<0.01). Triglycerides 144-157 fibrinogen beta chain Homo sapiens 0-10 9843166-6 1998 Fibrinogen level increased with age, smoking, waist-to-hip ratio, LDL-cholesterol, and it decreased with educational level, leisure physical activity, alcohol intake and HDL-cholesterol. Alcohols 151-158 fibrinogen beta chain Homo sapiens 0-10 9843175-4 1998 Men and ethanol drinkers showed lower plasma fibrinogen levels (p<0.01). Ethanol 8-15 fibrinogen beta chain Homo sapiens 45-55 9843166-6 1998 Fibrinogen level increased with age, smoking, waist-to-hip ratio, LDL-cholesterol, and it decreased with educational level, leisure physical activity, alcohol intake and HDL-cholesterol. Cholesterol 174-185 fibrinogen beta chain Homo sapiens 0-10 9863712-2 1998 We have studied the effect of different concentrations (0-20 micromol/l) of zinc ions (Zn2+) in the absence and presence of calcium on the gel structure formed in purified fibrinogen-enzyme systems. Zinc 87-91 fibrinogen beta chain Homo sapiens 172-182 9761721-21 1998 In the presence of Mn2+ cation, K562 cell adhesion on fibrinogen was observed in an alpha5 beta1-dependent manner. Manganese(2+) 19-23 fibrinogen beta chain Homo sapiens 54-64 9761721-22 1998 Under these conditions both PRGD and ARGD containing disintegrins were strong inhibitors of K562 cell adhesion on fibrinogen and this was due to a markedly improved recognition of the alpha5 beta1 complex by the PRGD molecules. argd 37-41 fibrinogen beta chain Homo sapiens 114-124 9746777-2 1998 Three sites on fibrinogen have been hypothesized to be critical for these interactions: the Ala-Gly-Asp-Val (AGDV) sequence at the C-terminus of the gamma chain and two Arg-Gly-Asp (RGD) sequences in the Aalpha chain. alanyl-glycyl-aspartyl-valine 92-107 fibrinogen beta chain Homo sapiens 15-25 9746777-2 1998 Three sites on fibrinogen have been hypothesized to be critical for these interactions: the Ala-Gly-Asp-Val (AGDV) sequence at the C-terminus of the gamma chain and two Arg-Gly-Asp (RGD) sequences in the Aalpha chain. agdv 109-113 fibrinogen beta chain Homo sapiens 15-25 9746777-2 1998 Three sites on fibrinogen have been hypothesized to be critical for these interactions: the Ala-Gly-Asp-Val (AGDV) sequence at the C-terminus of the gamma chain and two Arg-Gly-Asp (RGD) sequences in the Aalpha chain. Arginine 169-172 fibrinogen beta chain Homo sapiens 15-25 9746777-2 1998 Three sites on fibrinogen have been hypothesized to be critical for these interactions: the Ala-Gly-Asp-Val (AGDV) sequence at the C-terminus of the gamma chain and two Arg-Gly-Asp (RGD) sequences in the Aalpha chain. Glycine 96-99 fibrinogen beta chain Homo sapiens 15-25 9746777-2 1998 Three sites on fibrinogen have been hypothesized to be critical for these interactions: the Ala-Gly-Asp-Val (AGDV) sequence at the C-terminus of the gamma chain and two Arg-Gly-Asp (RGD) sequences in the Aalpha chain. Aspartic Acid 100-103 fibrinogen beta chain Homo sapiens 15-25 9781930-1 1998 The aim of this study was to compare the effects of the angiotensin-converting enzyme (ACE) inhibitor perindopril and the angiotensin II antagonist losartan on insulin sensitivity and plasma fibrinogen in overweight hypertensive patients. Perindopril 102-113 fibrinogen beta chain Homo sapiens 191-201 9781930-9 1998 Plasma fibrinogen levels were reduced by perindopril (-53.4 mg/dl, p = 0.022 vs. placebo) but not by losartan (-16.8 mg/dl, NS). Perindopril 41-52 fibrinogen beta chain Homo sapiens 7-17 9781930-10 1998 The perindopril-induced decrease in fibrinogen was correlated with the increase in GIR (r = 0.39; p < 0.01). Perindopril 4-15 fibrinogen beta chain Homo sapiens 36-46 9791170-1 1998 The surface-located fibrinogen-binding protein (clumping factor; ClfA) of Staphylococcus aureus has an unusual dipeptide repeat linking the ligand binding domain to the wall-anchored region. Dipeptides 111-120 fibrinogen beta chain Homo sapiens 20-30 9791170-14 1998 ClfB-dependent bacterial adherence to immobilized fibrinogen was inhibited by millimolar concentrations of Ca2+ and Mn2+, which indicates that, like ClfA, ligand binding by ClfB is regulated by a low-affinity inhibitory cation binding site. Manganese(2+) 116-120 fibrinogen beta chain Homo sapiens 50-60 9791170-14 1998 ClfB-dependent bacterial adherence to immobilized fibrinogen was inhibited by millimolar concentrations of Ca2+ and Mn2+, which indicates that, like ClfA, ligand binding by ClfB is regulated by a low-affinity inhibitory cation binding site. clfa 149-153 fibrinogen beta chain Homo sapiens 50-60 9758753-0 1998 Facile purification of fibrinogen fragments using a computer-based model with general applicability to the generation of salt gradients. Salts 121-125 fibrinogen beta chain Homo sapiens 23-33 9753458-0 1998 Substitution of tyrosine for phenylalanine in fibrinopeptide A results in preferential thrombin cleavage of fibrinopeptide B from fibrinogen. Tyrosine 16-24 fibrinogen beta chain Homo sapiens 130-140 9753458-0 1998 Substitution of tyrosine for phenylalanine in fibrinopeptide A results in preferential thrombin cleavage of fibrinopeptide B from fibrinogen. Phenylalanine 29-42 fibrinogen beta chain Homo sapiens 130-140 9753458-1 1998 Phenylalanine at residue 8 in the Aalpha chain of fibrinogen is a highly conserved amino acid that is believed to be critical for binding and catalysis by the serine protease thrombin. Phenylalanine 0-13 fibrinogen beta chain Homo sapiens 50-60 9753458-2 1998 We have examined the requirement for Phe at this position by constructing a variant recombinant fibrinogen with a conservative substitution of tyrosine for phenylalanine, Aalpha F8Y fibrinogen. Phenylalanine 37-40 fibrinogen beta chain Homo sapiens 96-106 9753458-2 1998 We have examined the requirement for Phe at this position by constructing a variant recombinant fibrinogen with a conservative substitution of tyrosine for phenylalanine, Aalpha F8Y fibrinogen. Tyrosine 143-151 fibrinogen beta chain Homo sapiens 96-106 9753458-2 1998 We have examined the requirement for Phe at this position by constructing a variant recombinant fibrinogen with a conservative substitution of tyrosine for phenylalanine, Aalpha F8Y fibrinogen. Phenylalanine 156-169 fibrinogen beta chain Homo sapiens 96-106 9753458-9 1998 These results confirm the importance of phenylalanine at Aalpha chain residue 8 for efficient thrombin-catalyzed proteolysis of fibrinogen, and further demonstrate that sequential fibrinopeptide release has an important role in normal polymerization. Phenylalanine 40-53 fibrinogen beta chain Homo sapiens 128-138 9772010-3 1998 We now report that after PAF stimulation, using flow cytometry, the amount of fibrinogen bound to its receptor was significantly lower in PV platelets with a median MFI of 6.0 (range 4.1-17.3) compared to controls, 12.8 (range 8-21.3; n=11; p<0.01). Platelet Activating Factor 25-28 fibrinogen beta chain Homo sapiens 78-88 9732910-0 1998 Effect of niacin supplementation on fibrinogen levels in patients with peripheral vascular disease. Niacin 10-16 fibrinogen beta chain Homo sapiens 36-46 9732910-1 1998 This study demonstrates that niacin supplementation decreases plasma fibrinogen and low-density lipoprotein cholesterol in subjects with peripheral vascular disease randomized to receive niacin, warfarin, antioxidants, or placebo. Niacin 29-35 fibrinogen beta chain Homo sapiens 69-79 9732910-2 1998 Changes in fibrinogen levels are highly correlated with changes in low-density lipoprotein cholesterol (r = 0.61; p < 0.009) in subjects taking niacin. Niacin 147-153 fibrinogen beta chain Homo sapiens 11-21 9818055-0 1998 Fibrinogen A alpha chain Leu 554: an African-American kindred with late onset renal amyloidosis. Leucine 25-28 fibrinogen beta chain Homo sapiens 0-10 9818055-4 1998 DNA analysis showed that patients were heterozygous for a mutation in the fibrinogen A alpha chain gene with a guanine to thymine transversion at the second base of codon 554, predicting a leucine for arginine substitution. Guanine 111-118 fibrinogen beta chain Homo sapiens 74-84 9818055-4 1998 DNA analysis showed that patients were heterozygous for a mutation in the fibrinogen A alpha chain gene with a guanine to thymine transversion at the second base of codon 554, predicting a leucine for arginine substitution. Thymine 122-129 fibrinogen beta chain Homo sapiens 74-84 9818055-4 1998 DNA analysis showed that patients were heterozygous for a mutation in the fibrinogen A alpha chain gene with a guanine to thymine transversion at the second base of codon 554, predicting a leucine for arginine substitution. Leucine 189-196 fibrinogen beta chain Homo sapiens 74-84 9818055-4 1998 DNA analysis showed that patients were heterozygous for a mutation in the fibrinogen A alpha chain gene with a guanine to thymine transversion at the second base of codon 554, predicting a leucine for arginine substitution. Arginine 201-209 fibrinogen beta chain Homo sapiens 74-84 9819001-2 1998 SR121566 dose-dependently inhibited adenosine diphosphate (ADP)-induced platelet fibrinogen binding determined either by flow cytometry analysis (IC50=50 nmol/l) or by measuring the binding of 125I-fibrinogen to activated human gel-filtered platelets (IC50=20 nmol/l). SR 121566 0-8 fibrinogen beta chain Homo sapiens 81-91 9819001-2 1998 SR121566 dose-dependently inhibited adenosine diphosphate (ADP)-induced platelet fibrinogen binding determined either by flow cytometry analysis (IC50=50 nmol/l) or by measuring the binding of 125I-fibrinogen to activated human gel-filtered platelets (IC50=20 nmol/l). SR 121566 0-8 fibrinogen beta chain Homo sapiens 198-208 9819001-2 1998 SR121566 dose-dependently inhibited adenosine diphosphate (ADP)-induced platelet fibrinogen binding determined either by flow cytometry analysis (IC50=50 nmol/l) or by measuring the binding of 125I-fibrinogen to activated human gel-filtered platelets (IC50=20 nmol/l). Adenosine Diphosphate 36-57 fibrinogen beta chain Homo sapiens 81-91 9819001-2 1998 SR121566 dose-dependently inhibited adenosine diphosphate (ADP)-induced platelet fibrinogen binding determined either by flow cytometry analysis (IC50=50 nmol/l) or by measuring the binding of 125I-fibrinogen to activated human gel-filtered platelets (IC50=20 nmol/l). Adenosine Diphosphate 36-57 fibrinogen beta chain Homo sapiens 198-208 9819001-2 1998 SR121566 dose-dependently inhibited adenosine diphosphate (ADP)-induced platelet fibrinogen binding determined either by flow cytometry analysis (IC50=50 nmol/l) or by measuring the binding of 125I-fibrinogen to activated human gel-filtered platelets (IC50=20 nmol/l). Adenosine Diphosphate 59-62 fibrinogen beta chain Homo sapiens 81-91 9819001-2 1998 SR121566 dose-dependently inhibited adenosine diphosphate (ADP)-induced platelet fibrinogen binding determined either by flow cytometry analysis (IC50=50 nmol/l) or by measuring the binding of 125I-fibrinogen to activated human gel-filtered platelets (IC50=20 nmol/l). Adenosine Diphosphate 59-62 fibrinogen beta chain Homo sapiens 198-208 9819001-3 1998 Consistent with its inhibitory effects on platelet fibrinogen binding, SR121566 demonstrated a dose-dependent inhibition of collagen-, ADP- or thrombin-induced platelet aggregation with IC50 values ranging between 20 and 60 nmol/l. SR 121566 71-79 fibrinogen beta chain Homo sapiens 51-61 9787165-1 1998 The promoter region of the Bbeta fibrinogen gene containing the polymorphic site (G-455-A) shows an increase in fibrinogen levels for individuals containing an adenine rather than a guanine. Adenine 160-167 fibrinogen beta chain Homo sapiens 33-43 9787165-1 1998 The promoter region of the Bbeta fibrinogen gene containing the polymorphic site (G-455-A) shows an increase in fibrinogen levels for individuals containing an adenine rather than a guanine. Adenine 160-167 fibrinogen beta chain Homo sapiens 112-122 9787165-1 1998 The promoter region of the Bbeta fibrinogen gene containing the polymorphic site (G-455-A) shows an increase in fibrinogen levels for individuals containing an adenine rather than a guanine. Guanine 182-189 fibrinogen beta chain Homo sapiens 33-43 9787167-0 1998 Formation of the human fibrinogen subclass fib420: disulfide bonds and glycosylation in its unique (alphaE chain) domains. Disulfides 51-60 fibrinogen beta chain Homo sapiens 23-33 9949668-0 1998 Effects of metformin on fibrinogen levels in obese patients with type 2 diabetes. Metformin 11-20 fibrinogen beta chain Homo sapiens 24-34 9949668-13 1998 CONCLUSIONS: In addition to improving metabolic control, metformin showed to be a good therapeutic alternative in modifying fibrinogen levels in type 2 diabetic patients. Metformin 57-66 fibrinogen beta chain Homo sapiens 124-134 10933414-9 1998 Univariate and multivariate analyses revealed significant (P<0.05) positive correlations of fibrinogen with smoking habit, age, body mass index (BMI), total and low-density lipoprotein (LDL) cholesterol, triglycerides, blood pressure and white blood cell count, and significant negative correlations with high-density lipoprotein (HDL) cholesterol, gamma glutamyl transferase (GGT), serum iron and ferritin. Cholesterol 194-205 fibrinogen beta chain Homo sapiens 95-105 10933414-9 1998 Univariate and multivariate analyses revealed significant (P<0.05) positive correlations of fibrinogen with smoking habit, age, body mass index (BMI), total and low-density lipoprotein (LDL) cholesterol, triglycerides, blood pressure and white blood cell count, and significant negative correlations with high-density lipoprotein (HDL) cholesterol, gamma glutamyl transferase (GGT), serum iron and ferritin. Triglycerides 207-220 fibrinogen beta chain Homo sapiens 95-105 10933414-9 1998 Univariate and multivariate analyses revealed significant (P<0.05) positive correlations of fibrinogen with smoking habit, age, body mass index (BMI), total and low-density lipoprotein (LDL) cholesterol, triglycerides, blood pressure and white blood cell count, and significant negative correlations with high-density lipoprotein (HDL) cholesterol, gamma glutamyl transferase (GGT), serum iron and ferritin. Cholesterol 339-350 fibrinogen beta chain Homo sapiens 95-105 10933414-9 1998 Univariate and multivariate analyses revealed significant (P<0.05) positive correlations of fibrinogen with smoking habit, age, body mass index (BMI), total and low-density lipoprotein (LDL) cholesterol, triglycerides, blood pressure and white blood cell count, and significant negative correlations with high-density lipoprotein (HDL) cholesterol, gamma glutamyl transferase (GGT), serum iron and ferritin. Iron 392-396 fibrinogen beta chain Homo sapiens 95-105 10933414-10 1998 The correlations with BMI, serum lipoproteins, iron, ferritin, and GGT suggest that nutritional status and therefore diet influences plasma fibrinogen. Iron 47-51 fibrinogen beta chain Homo sapiens 140-150 9712878-3 1998 We have demonstrated, however, that a double mutation of Asp199-Gly200 to Gly-Ala in the recombinant gamma-module of fibrinogen, spanning region 148-411, did not abrogate alphaM beta2 recognition and considered that other binding sites in the gamma-module may participate in the receptor recognition. N-glycylalanine 74-81 fibrinogen beta chain Homo sapiens 117-127 9694716-7 1998 By the stimulation with soluble fibrinogen, Syk was tyrosine-phosphorylated but FAK was dephosphorylated, whereas solid-phase fibrinogen promptly caused tyrosine phosphorylation of FAK followed by delayed phosphorylation of Syk. Tyrosine 52-60 fibrinogen beta chain Homo sapiens 32-42 9694716-7 1998 By the stimulation with soluble fibrinogen, Syk was tyrosine-phosphorylated but FAK was dephosphorylated, whereas solid-phase fibrinogen promptly caused tyrosine phosphorylation of FAK followed by delayed phosphorylation of Syk. Tyrosine 153-161 fibrinogen beta chain Homo sapiens 32-42 9694716-7 1998 By the stimulation with soluble fibrinogen, Syk was tyrosine-phosphorylated but FAK was dephosphorylated, whereas solid-phase fibrinogen promptly caused tyrosine phosphorylation of FAK followed by delayed phosphorylation of Syk. Tyrosine 153-161 fibrinogen beta chain Homo sapiens 126-136 9694716-8 1998 In addition, the binding of soluble fibrinogen to the cells adherent to fibrinogen-coated plate resulted in tyrosine phosphorylation of integrin beta3 and a complex formation of integrin beta3 with Syk. Tyrosine 108-116 fibrinogen beta chain Homo sapiens 36-46 9694716-8 1998 In addition, the binding of soluble fibrinogen to the cells adherent to fibrinogen-coated plate resulted in tyrosine phosphorylation of integrin beta3 and a complex formation of integrin beta3 with Syk. Tyrosine 108-116 fibrinogen beta chain Homo sapiens 72-82 9710118-4 1998 The results of the present study demonstrate that factor XIIIa, a transglutaminase that catalyzes the formation of amide bonds between endo-gamma-glutaminyl and endo-epsilon-lysyl residues of proteins, is capable of cross-linking Lp(a) to fibrinogen, the soluble precursor of fibrin. Amides 115-120 fibrinogen beta chain Homo sapiens 239-249 9724163-1 1998 The anticoagulant activity of antithrombin III (ATIII), as observed in a plasma-free system consisting of thrombin and fibrinogen, is readily reduced by acetaldehyde (AcH) at concentrations of 447, 89.4, and 17.9 mM. Acetaldehyde 153-165 fibrinogen beta chain Homo sapiens 119-129 9724163-1 1998 The anticoagulant activity of antithrombin III (ATIII), as observed in a plasma-free system consisting of thrombin and fibrinogen, is readily reduced by acetaldehyde (AcH) at concentrations of 447, 89.4, and 17.9 mM. Acetaldehyde 167-170 fibrinogen beta chain Homo sapiens 119-129 9793253-10 1998 Conversely, white blood cell (WBC) count and serum cholesterol levels were significantly associated with high fibrinogen levels (p < 0.0001). Cholesterol 51-62 fibrinogen beta chain Homo sapiens 110-120 9726698-1 1998 Elevated serum triglyceride levels may be related to the following clinical features: increased blood coagulation and viscosity, increased serum fibrinogen levels, decreased fibrinolysis, and for serum levels over 1000 mg/dl, a strong increase of acute pancreatitis rate. Triglycerides 15-27 fibrinogen beta chain Homo sapiens 145-155 9687556-11 1998 Assuming that tryptophan is limiting, up to 2.6 g muscle protein ( approximately 12 g skeletal muscle tissue) may be wasted to synthesize 1 g fibrinogen. Tryptophan 14-24 fibrinogen beta chain Homo sapiens 142-152 9864967-7 1998 As shown by SDS-polyacrylamide gel electrophoresis, HAT cleaved fibrinogen, especially its alpha-chain, regardless of the concentration of fibrinogen. Sodium Dodecyl Sulfate 12-15 fibrinogen beta chain Homo sapiens 64-74 9864967-7 1998 As shown by SDS-polyacrylamide gel electrophoresis, HAT cleaved fibrinogen, especially its alpha-chain, regardless of the concentration of fibrinogen. polyacrylamide 16-30 fibrinogen beta chain Homo sapiens 64-74 9733156-0 1998 Characterization of the binding of FK633 to the platelet fibrinogen receptor. ((4-(4-amidinophenoxy)butanoyl)aspartyl)valine 35-40 fibrinogen beta chain Homo sapiens 57-67 9687556-6 1998 Fibrinogen synthesis was measured after an overnight fast, using a flooding dose of 2H5-phenylalanine. 2h5-phenylalanine 84-101 fibrinogen beta chain Homo sapiens 0-10 9687556-9 1998 We calculated that, in cancer patients with anorexia-cachexia (i.e., documented ongoing weight loss in the absence of an obvious cause such as obstruction or malabsorption), aromatic amino acid supply (predominantly tryptophan) most limits fibrinogen synthesis from skeletal muscle reserves. Amino Acids, Aromatic 174-193 fibrinogen beta chain Homo sapiens 240-250 9687556-9 1998 We calculated that, in cancer patients with anorexia-cachexia (i.e., documented ongoing weight loss in the absence of an obvious cause such as obstruction or malabsorption), aromatic amino acid supply (predominantly tryptophan) most limits fibrinogen synthesis from skeletal muscle reserves. Tryptophan 216-226 fibrinogen beta chain Homo sapiens 240-250 9716150-0 1998 Oligosaccharide configuration of fibrinogen Kaiserslautern: electrospray ionisation analysis of intact gamma chains. Oligosaccharides 0-15 fibrinogen beta chain Homo sapiens 33-43 9716150-1 1998 Electrospray ionisation mass spectrometry was used to probe the structure of the new N-linked oligosaccharide in fibrinogen Kaiserslautern (gamma 380 Lys-->Asn). n-linked oligosaccharide 85-109 fibrinogen beta chain Homo sapiens 113-123 9733156-1 1998 125I-fibrinogen bound to ADP-activated fixed platelets in a saturable manner. Adenosine Diphosphate 25-28 fibrinogen beta chain Homo sapiens 5-15 9716150-1 1998 Electrospray ionisation mass spectrometry was used to probe the structure of the new N-linked oligosaccharide in fibrinogen Kaiserslautern (gamma 380 Lys-->Asn). Lysine 150-153 fibrinogen beta chain Homo sapiens 113-123 9716150-1 1998 Electrospray ionisation mass spectrometry was used to probe the structure of the new N-linked oligosaccharide in fibrinogen Kaiserslautern (gamma 380 Lys-->Asn). Asparagine 159-162 fibrinogen beta chain Homo sapiens 113-123 9733156-3 1998 The GPIIb/IIIa antagonists RGDS and FK633 both inhibited 125I-fibrinogen binding (50 microg/ml) in a dose-dependent manner. ((4-(4-amidinophenoxy)butanoyl)aspartyl)valine 36-41 fibrinogen beta chain Homo sapiens 62-72 9716150-4 1998 Mass measurements of intact Kaiserslautern gamma chains after neuraminidase treatment of the native fibrinogen confirmed a total of three residues of sialic acid in the dominant isoform. N-Acetylneuraminic Acid 150-161 fibrinogen beta chain Homo sapiens 100-110 9733156-5 1998 At concentrations below its IC50 value FK633 was a competitive antagonist of fibrinogen binding. ((4-(4-amidinophenoxy)butanoyl)aspartyl)valine 39-44 fibrinogen beta chain Homo sapiens 77-87 9733156-7 1998 The IC50 values of FK633 remained constant over a wide range of fibrinogen concentrations while its KB value changed-increasing from 1.8+/-0.6 x 10(7) M(-1) at 10 microg/ml 125I-fibrinogen to 4.5+/-1.6 x 10(7) M(-1) at 300 microg/ml and decreasing to 0.3+/-0.2 x 10(7) M(-1) at 2.4 mg/ml. ((4-(4-amidinophenoxy)butanoyl)aspartyl)valine 19-24 fibrinogen beta chain Homo sapiens 64-74 9716150-7 1998 It appears that the polymerisation defect of this fibrinogen results from electrostatic repulsion between condensing protofibrils and that this is induced by the two new residues of sialic acid that are present on the new gamma chain. N-Acetylneuraminic Acid 182-193 fibrinogen beta chain Homo sapiens 50-60 9733156-7 1998 The IC50 values of FK633 remained constant over a wide range of fibrinogen concentrations while its KB value changed-increasing from 1.8+/-0.6 x 10(7) M(-1) at 10 microg/ml 125I-fibrinogen to 4.5+/-1.6 x 10(7) M(-1) at 300 microg/ml and decreasing to 0.3+/-0.2 x 10(7) M(-1) at 2.4 mg/ml. ((4-(4-amidinophenoxy)butanoyl)aspartyl)valine 19-24 fibrinogen beta chain Homo sapiens 178-188 9733156-8 1998 Thus, FK633 is a reversible, noncompetitive antagonist of fibrinogen binding to the platelet GPIIb/IIIa receptor. ((4-(4-amidinophenoxy)butanoyl)aspartyl)valine 6-11 fibrinogen beta chain Homo sapiens 58-68 9717059-6 1998 Indeed, studies confirm that the positive association between plasma fibrinogen levels and cardiovascular events is a predictive as elevated cholesterol levels. Cholesterol 141-152 fibrinogen beta chain Homo sapiens 69-79 9784905-3 1998 Indeed, raised fibrinogen levels may pose as great a cardiovascular risk as classical risk factors such as elevated blood pressure or cholesterol levels. Cholesterol 134-145 fibrinogen beta chain Homo sapiens 15-25 9655393-8 1998 In hyperlipidaemic patients, fenofibrate treatment decreases the plasma concentrations of interleukin-6, fibrinogen and C-reactive protein. Fenofibrate 29-40 fibrinogen beta chain Homo sapiens 105-115 9633924-8 1998 Taken together, these findings indicate that the HDL3-mediated inhibition of thrombin-induced fibrinogen binding and aggregation occurs via inhibition of phosphatidylinositol 4,5-bis-phosphate turnover and formation of 1,2-diacylglycerol and inositol 1,4,5-tris-phosphate. Phosphatidylinositol 4,5-Diphosphate 154-192 fibrinogen beta chain Homo sapiens 94-104 9637652-7 1998 RESULTS: Agonist-induced platelet aggregation and fibrinogen binding were significantly greater at 22 degrees C and 33 degrees C than at 37 degrees C. Platelet fibrinogen binding values to 20 micro M ADP were 23,400, 14,300, and 9,700 molecules/platelet at 22 degrees C, 33 degrees C, and 37 degrees C, respectively. Adenosine Diphosphate 200-203 fibrinogen beta chain Homo sapiens 160-170 9633924-8 1998 Taken together, these findings indicate that the HDL3-mediated inhibition of thrombin-induced fibrinogen binding and aggregation occurs via inhibition of phosphatidylinositol 4,5-bis-phosphate turnover and formation of 1,2-diacylglycerol and inositol 1,4,5-tris-phosphate. 1,2-diacylglycerol 219-237 fibrinogen beta chain Homo sapiens 94-104 9633924-8 1998 Taken together, these findings indicate that the HDL3-mediated inhibition of thrombin-induced fibrinogen binding and aggregation occurs via inhibition of phosphatidylinositol 4,5-bis-phosphate turnover and formation of 1,2-diacylglycerol and inositol 1,4,5-tris-phosphate. Inositol 1,4,5-Trisphosphate 242-271 fibrinogen beta chain Homo sapiens 94-104 9699932-11 1998 Patients with bleeding complications revealed significant lower nadir levels of fibrinogen than patients without bleeding complications (54 mg/dl versus 125.5 mg/dl, P=0.02). nadir 64-69 fibrinogen beta chain Homo sapiens 80-90 9630497-0 1998 Role of the gamma chain Ala-Gly-Asp-Val and Aalpha chain Arg-Gly-Asp-Ser sites of fibrinogen in coaggregation of platelets and fibrinogen-coated beads. Arginine 57-60 fibrinogen beta chain Homo sapiens 82-92 9630497-0 1998 Role of the gamma chain Ala-Gly-Asp-Val and Aalpha chain Arg-Gly-Asp-Ser sites of fibrinogen in coaggregation of platelets and fibrinogen-coated beads. Serine 69-72 fibrinogen beta chain Homo sapiens 82-92 9630497-0 1998 Role of the gamma chain Ala-Gly-Asp-Val and Aalpha chain Arg-Gly-Asp-Ser sites of fibrinogen in coaggregation of platelets and fibrinogen-coated beads. Serine 69-72 fibrinogen beta chain Homo sapiens 127-137 9630497-4 1998 CA of platelets with Fg-beads was nearly abolished in the presence of 4A5, a monoclonal antibody (mAb) whose epitope includes AGDV, while Z69/8, a mAb that also binds to the gamma chain carboxyl terminus but does not cover AGDV, had little effect. agdv 126-130 fibrinogen beta chain Homo sapiens 21-23 9699932-15 1998 Patients with bleeding complications reveal significant lower nadir levels of fibrinogen than patients without bleeding complications. nadir 62-67 fibrinogen beta chain Homo sapiens 78-88 9654873-4 1998 The median (range) fibrinogen levels (expressed as a percentage of that in unexposed blood samples) were: standard dacron 3.5% (0-5.4%); PTFE 95.5% (0-121.1%); and heparin-bound dacron 79.8% (3.8-109.6%). Polyethylene Terephthalates 115-121 fibrinogen beta chain Homo sapiens 19-29 9654873-4 1998 The median (range) fibrinogen levels (expressed as a percentage of that in unexposed blood samples) were: standard dacron 3.5% (0-5.4%); PTFE 95.5% (0-121.1%); and heparin-bound dacron 79.8% (3.8-109.6%). Polytetrafluoroethylene 137-141 fibrinogen beta chain Homo sapiens 19-29 9654873-5 1998 Fibrinogen levels in the standard dacron group were significantly less than that of the PTFE and heparin-bound dacron groups (P < 0.05). Polyethylene Terephthalates 34-40 fibrinogen beta chain Homo sapiens 0-10 9654873-5 1998 Fibrinogen levels in the standard dacron group were significantly less than that of the PTFE and heparin-bound dacron groups (P < 0.05). Polytetrafluoroethylene 88-92 fibrinogen beta chain Homo sapiens 0-10 9654873-5 1998 Fibrinogen levels in the standard dacron group were significantly less than that of the PTFE and heparin-bound dacron groups (P < 0.05). Heparin 97-104 fibrinogen beta chain Homo sapiens 0-10 9654873-7 1998 These findings suggest that heparin binding significantly reduces fibrinogen consumption and hence may reduce graft thrombogenicity. Heparin 28-35 fibrinogen beta chain Homo sapiens 66-76 9590268-4 1998 In the present study, we observed increased tyrosine phosphorylation of both focal adhesion kinase and Syk in FMLP-activated PMNs that had been plated onto fibrinogen; an increase in Syk activity, but not focal adhesion kinase activity, was apparent. Tyrosine 44-52 fibrinogen beta chain Homo sapiens 156-166 9834619-9 1998 (6) When control plasmas of three different Fbg concentrations were assayed, the number of the institutes which obtained a value greater than 3 standard deviations (SDs) was highest for the control plasma with the lowest concentrations of Fbg, and some of the instruments were not able to measure such a low Fbg concentration. sds 165-168 fibrinogen beta chain Homo sapiens 44-47 9834619-9 1998 (6) When control plasmas of three different Fbg concentrations were assayed, the number of the institutes which obtained a value greater than 3 standard deviations (SDs) was highest for the control plasma with the lowest concentrations of Fbg, and some of the instruments were not able to measure such a low Fbg concentration. sds 165-168 fibrinogen beta chain Homo sapiens 239-242 9834619-9 1998 (6) When control plasmas of three different Fbg concentrations were assayed, the number of the institutes which obtained a value greater than 3 standard deviations (SDs) was highest for the control plasma with the lowest concentrations of Fbg, and some of the instruments were not able to measure such a low Fbg concentration. sds 165-168 fibrinogen beta chain Homo sapiens 239-242 9691771-5 1998 We converted a ratio of fibrinogen binding platelets to a velocity per unit concentration of ADP as follows: a difference of two ratios of fibrinogen binding platelets on neighboring two ADP concentrations was divided by a difference of ADP concentrations. Adenosine Diphosphate 93-96 fibrinogen beta chain Homo sapiens 139-149 9691771-5 1998 We converted a ratio of fibrinogen binding platelets to a velocity per unit concentration of ADP as follows: a difference of two ratios of fibrinogen binding platelets on neighboring two ADP concentrations was divided by a difference of ADP concentrations. Adenosine Diphosphate 187-190 fibrinogen beta chain Homo sapiens 24-34 9691771-5 1998 We converted a ratio of fibrinogen binding platelets to a velocity per unit concentration of ADP as follows: a difference of two ratios of fibrinogen binding platelets on neighboring two ADP concentrations was divided by a difference of ADP concentrations. Adenosine Diphosphate 187-190 fibrinogen beta chain Homo sapiens 139-149 9691771-5 1998 We converted a ratio of fibrinogen binding platelets to a velocity per unit concentration of ADP as follows: a difference of two ratios of fibrinogen binding platelets on neighboring two ADP concentrations was divided by a difference of ADP concentrations. Adenosine Diphosphate 187-190 fibrinogen beta chain Homo sapiens 24-34 9691771-5 1998 We converted a ratio of fibrinogen binding platelets to a velocity per unit concentration of ADP as follows: a difference of two ratios of fibrinogen binding platelets on neighboring two ADP concentrations was divided by a difference of ADP concentrations. Adenosine Diphosphate 187-190 fibrinogen beta chain Homo sapiens 139-149 9695672-6 1998 The DIC score improved and the anti-fibrinogen antibody disappeared in association with the response of SLE to prednisolone therapy. Prednisolone 111-123 fibrinogen beta chain Homo sapiens 36-46 9558384-2 1998 The truncated Aalpha-chain of fibrinogen Marburg is partly linked with albumin by a disulfide bond. Disulfides 84-93 fibrinogen beta chain Homo sapiens 30-40 9692616-10 1998 Ketanserin produced a decrease in ristocetin-induced platelet aggregation, fibrinogen, and prolongation of the bleeding time. Ketanserin 0-10 fibrinogen beta chain Homo sapiens 75-85 9588389-5 1998 Synthetic compounds were subsequently produced containing the specific arginine-glycine-aspartic acid (RGD) sequence for fibrinogen binding to the receptor. arginyl-glycyl-aspartic acid 71-101 fibrinogen beta chain Homo sapiens 121-131 9678787-15 1998 Plasma fibrinogen was increased (P < 0.05) by gemfibrozil (placebo 4.16 (3.38-4.71) and gemfibrozil 4.65 (4.05-5.77) g/l) and was significantly lower (P < 0.001) on bezafibrate (3.60 (3.18-4.54) g/l) than on gemfibrozil treatment. Gemfibrozil 49-60 fibrinogen beta chain Homo sapiens 7-17 9678787-15 1998 Plasma fibrinogen was increased (P < 0.05) by gemfibrozil (placebo 4.16 (3.38-4.71) and gemfibrozil 4.65 (4.05-5.77) g/l) and was significantly lower (P < 0.001) on bezafibrate (3.60 (3.18-4.54) g/l) than on gemfibrozil treatment. Gemfibrozil 91-102 fibrinogen beta chain Homo sapiens 7-17 9678787-15 1998 Plasma fibrinogen was increased (P < 0.05) by gemfibrozil (placebo 4.16 (3.38-4.71) and gemfibrozil 4.65 (4.05-5.77) g/l) and was significantly lower (P < 0.001) on bezafibrate (3.60 (3.18-4.54) g/l) than on gemfibrozil treatment. Bezafibrate 171-182 fibrinogen beta chain Homo sapiens 7-17 9678787-15 1998 Plasma fibrinogen was increased (P < 0.05) by gemfibrozil (placebo 4.16 (3.38-4.71) and gemfibrozil 4.65 (4.05-5.77) g/l) and was significantly lower (P < 0.001) on bezafibrate (3.60 (3.18-4.54) g/l) than on gemfibrozil treatment. Gemfibrozil 91-102 fibrinogen beta chain Homo sapiens 7-17 9678787-20 1998 The two drugs also had different effects on the plasma fibrinogen levels, which increased with gemfibrozil and tended to decrea Gemfibrozil 95-106 fibrinogen beta chain Homo sapiens 55-65 9717004-9 1998 Platelet activation measures were not consistently related to other coronary risk factors, while fibrinogen was related to triglyceride and insulin levels among Indians. Triglycerides 123-135 fibrinogen beta chain Homo sapiens 97-107 9703738-1 1998 Sulfite-alkaline method after Rampling and Gaffney is proposed for measuring fibrinogen and fibrin degradation products in cadaveric blood. Sulfites 0-7 fibrinogen beta chain Homo sapiens 77-87 9690711-9 1998 Thus, we demonstrate that 13-HODE downregulates VnR binding with vitronectin (Vn) > fibronectin (Fn) > fibrinogen (Fgn), whereas 12- and 15-HETE upregulate specific VnR/ligand binding, using purified VnR/liposomes and purified ligands in an adhesion assay; and that 12- and 15-HETE upregulate GPIIb/IIIa:liposome binding of Fgn > Fn > Vn. 13-hydroxy-9,11-octadecadienoic acid 26-33 fibrinogen beta chain Homo sapiens 109-119 9690711-9 1998 Thus, we demonstrate that 13-HODE downregulates VnR binding with vitronectin (Vn) > fibronectin (Fn) > fibrinogen (Fgn), whereas 12- and 15-HETE upregulate specific VnR/ligand binding, using purified VnR/liposomes and purified ligands in an adhesion assay; and that 12- and 15-HETE upregulate GPIIb/IIIa:liposome binding of Fgn > Fn > Vn. 13-hydroxy-9,11-octadecadienoic acid 26-33 fibrinogen beta chain Homo sapiens 121-124 9690711-9 1998 Thus, we demonstrate that 13-HODE downregulates VnR binding with vitronectin (Vn) > fibronectin (Fn) > fibrinogen (Fgn), whereas 12- and 15-HETE upregulate specific VnR/ligand binding, using purified VnR/liposomes and purified ligands in an adhesion assay; and that 12- and 15-HETE upregulate GPIIb/IIIa:liposome binding of Fgn > Fn > Vn. 13-hydroxy-9,11-octadecadienoic acid 26-33 fibrinogen beta chain Homo sapiens 330-333 9684758-7 1998 Results showed that the administration of fibrinogen increases the number of emboli, the duration of embolization, the amplitude, and the velocity of the ex-vivo platelet aggregation induced by ADP (p < 0.05). Adenosine Diphosphate 194-197 fibrinogen beta chain Homo sapiens 42-52 9820067-0 1998 [Bezafibrate in the treatment of familial combined hyperlipidemia and its effect on certain parameters of lipid metabolism, particularly fibrinogen]. Bezafibrate 1-12 fibrinogen beta chain Homo sapiens 137-147 9663708-6 1998 The PFC overestimate by the prothrombin-time-derived method could also be experimentally reproduced by competitively inhibiting thrombin-fibrinogen interaction by hirudin 54-65 peptide and the fibrinogen fragment E. A similar qualitative result was also found for the prothrombin-time-derived method in the presence of the Gly-Pro-Arg-Pro peptide, which competitively inhibits the end-to-end fibrin aggregation process. gly-pro-arg-pro peptide 323-346 fibrinogen beta chain Homo sapiens 137-147 9576177-0 1998 Electrospray ionization mass spectrometry identification of fibrinogen Banks Peninsula (gamma280Tyr-->Cys): a new variant with defective polymerization. Cysteine 105-108 fibrinogen beta chain Homo sapiens 60-70 9568745-3 1998 RESULTS: Fibrinogen was increased in all patients, and by each treatment category, when compared with the control group (421+/-143 all, 361+/-72 HD, 429+/-91 CAPD, 395+/-102 LP, 490+/-220 HP vs. 268+/-54 (N) mg/dl; P=0.0001) and correlated with urinary protein concentration, diastolic blood pressure and inversely with albumin. leucylproline 174-176 fibrinogen beta chain Homo sapiens 9-19 9571358-6 1998 RESULTS: Age-adjusted fibrinogen levels correlated significantly with BMI, waist-to-hip ratio, systolic and diastolic blood pressure, plasma total cholesterol, LDL cholesterol, triglycerides, insulin, and HDL cholesterol (inversely). Cholesterol 147-158 fibrinogen beta chain Homo sapiens 22-32 9571358-6 1998 RESULTS: Age-adjusted fibrinogen levels correlated significantly with BMI, waist-to-hip ratio, systolic and diastolic blood pressure, plasma total cholesterol, LDL cholesterol, triglycerides, insulin, and HDL cholesterol (inversely). Cholesterol 164-175 fibrinogen beta chain Homo sapiens 22-32 9571358-6 1998 RESULTS: Age-adjusted fibrinogen levels correlated significantly with BMI, waist-to-hip ratio, systolic and diastolic blood pressure, plasma total cholesterol, LDL cholesterol, triglycerides, insulin, and HDL cholesterol (inversely). Triglycerides 177-190 fibrinogen beta chain Homo sapiens 22-32 9571358-6 1998 RESULTS: Age-adjusted fibrinogen levels correlated significantly with BMI, waist-to-hip ratio, systolic and diastolic blood pressure, plasma total cholesterol, LDL cholesterol, triglycerides, insulin, and HDL cholesterol (inversely). Cholesterol 164-175 fibrinogen beta chain Homo sapiens 22-32 9585395-7 1998 Multiple linear regression analysis showed associations between HbA1c and fibrinogen (p < 0.001), total cholesterol (p = 0.006), and triglycerides (p = 0.04), independent of age, sex, duration of diabetes, and antidiabetic treatment. Triglycerides 136-149 fibrinogen beta chain Homo sapiens 64-84 9511103-5 1998 The thrombin-fibrinogen dissociation constant Ks served as the single adjustable parameter in a least-squares fitting of the model to experimental anticoagulation data. Potassium 46-48 fibrinogen beta chain Homo sapiens 13-23 9569199-2 1998 We previously observed that the fibrinogen concentration used to coat polystyrene wells affected the morphology and distribution of GP IIb/IIIa receptors on the surface of platelets adherent to the fibrinogen. Polystyrenes 70-81 fibrinogen beta chain Homo sapiens 32-42 9569199-2 1998 We previously observed that the fibrinogen concentration used to coat polystyrene wells affected the morphology and distribution of GP IIb/IIIa receptors on the surface of platelets adherent to the fibrinogen. Polystyrenes 70-81 fibrinogen beta chain Homo sapiens 198-208 9516457-4 1998 Binding studies were performed using bFGF immobilized on Sepharose beads and soluble 125I-labeled fibrinogen and also using Sepharose-immobilized fibrinogen and soluble 125I-bFGF. Sepharose 124-133 fibrinogen beta chain Homo sapiens 146-156 9677152-1 1998 We have used fibrinogen gold conjugates and fluorescein-labelled fibrinogen to examine the presence of fibrinogen receptors on the ventral membrane of spreading platelets and to visualize the redistribution of the receptors during platelet spreading. Fluorescein 44-55 fibrinogen beta chain Homo sapiens 65-75 9584421-0 1998 [Fibrinogen affects blood and bone marrow cell functions on titanium in vitro]. Titanium 60-68 fibrinogen beta chain Homo sapiens 1-11 9677152-1 1998 We have used fibrinogen gold conjugates and fluorescein-labelled fibrinogen to examine the presence of fibrinogen receptors on the ventral membrane of spreading platelets and to visualize the redistribution of the receptors during platelet spreading. Fluorescein 44-55 fibrinogen beta chain Homo sapiens 65-75 9677152-2 1998 The movement of fibrinogen gold conjugates was observed in real time using video-enhanced interference reflection microscopy (VEIRM) and the redistribution of fluorescein-labelled fibrinogen was examined using video-intensified epifluorescence microscopy (VIFM). Fluorescein 159-170 fibrinogen beta chain Homo sapiens 180-190 9504644-7 1998 A trend towards lower plasma viscosity (1.139 v 1.160 mPa/s) and plasma fibrinogen (2.28 v 2.44 g/l) was observed in women on oestrogen-progesterone combinations as compared with oestrogen monotherapy users: however, after controlling for the above-mentioned variables these differences were not statistically significant. Progesterone 136-148 fibrinogen beta chain Homo sapiens 72-82 9657246-1 1998 BACKGROUND: Ticlopidine inhibits platelet aggregation by preventing the binding of fibrinogen to its platelet receptor. Ticlopidine 12-23 fibrinogen beta chain Homo sapiens 83-93 9657246-7 1998 RESULTS: Platelet adhesion to plasma and fibrinogen was significantly reduced (about 50%) after treatment with ticlopidine, while adhesion to collagen was not modified. Ticlopidine 111-122 fibrinogen beta chain Homo sapiens 41-51 9523852-4 1998 We developed a new cell haptotactic/attachment assay by using Thr and Fib covalently bound to Sepharose beads (SBs). Sepharose 94-103 fibrinogen beta chain Homo sapiens 70-73 9584421-4 1998 On titanium coated with fibrinogen increases in not only NSE activity and PMN elastase activity in blood and bone marrow, but also tartrate-resistant acid phosphatase (TRACP) activity were observed in bone marrow cultures. Titanium 3-11 fibrinogen beta chain Homo sapiens 24-34 9584421-7 1998 These results suggested that bleeding around titanium affects the function of macrophages or neutrophils due to the effect of fibrinogen. Titanium 45-53 fibrinogen beta chain Homo sapiens 126-136 9541130-2 1998 We have addressed this problem by investigating the effects of bezafibrate on fibrinogen in the human hepatoma HepG2 cell line. Bezafibrate 63-74 fibrinogen beta chain Homo sapiens 78-88 9531053-0 1998 Inhibition of fibrinogen binding and surface recruitment of GpIIb/IIIa as dose-dependent effects of the RGD-mimetic MK-852. MK 0852 116-122 fibrinogen beta chain Homo sapiens 14-24 9531053-5 1998 MK-852 already in the nanomolar range completely inhibited the surface binding of fibrinogen to ADP or TRAP-6 stimulated platelets. MK 0852 0-6 fibrinogen beta chain Homo sapiens 82-92 9485375-6 1998 Proteolysis at Arg572 destroyed the Arg-Gly-Asp (RGD) sequence motif recognized by cell surface alphavbeta3 integrins, and endothelial cell binding to tryptase-modified fibrinogen was significantly reduced, consistent with loss of the RGD motif. Arginine 15-18 fibrinogen beta chain Homo sapiens 169-179 9492781-0 1998 Effect of atorvastatin on plasma fibrinogen. Atorvastatin 10-22 fibrinogen beta chain Homo sapiens 33-43 9465033-3 1998 At later times, long flexible polymers made up of 30 or more fibrinogen and fragment E units, with a tendency for lateral aggregation and tangle formation, were seen. Polymers 30-38 fibrinogen beta chain Homo sapiens 61-71 9484992-4 1998 In the present study we evaluated, in patients with serum cholesterol levels between 4 and 8 mmol/L, the relation of plasma levels and polymorphisms of fibrinogen with coronary artery disease (CAD), cross-sectionally at baseline and after a 2-year follow-up period in which they received either a placebo or pravastatin. Cholesterol 58-69 fibrinogen beta chain Homo sapiens 152-162 9484992-4 1998 In the present study we evaluated, in patients with serum cholesterol levels between 4 and 8 mmol/L, the relation of plasma levels and polymorphisms of fibrinogen with coronary artery disease (CAD), cross-sectionally at baseline and after a 2-year follow-up period in which they received either a placebo or pravastatin. Pravastatin 308-319 fibrinogen beta chain Homo sapiens 152-162 9519344-12 1998 The European Concerted Action on Thrombosis (ECAT) showed that the levels of fibrinogen, von Willebrand factor antigen, and t-PA antigen are independent predictors of subsequent coronary syndromes in patients with angina pectoris, and that low fibrinogen is associated with a low risk of events despite high cholesterol levels. Cholesterol 308-319 fibrinogen beta chain Homo sapiens 77-87 9541130-3 1998 METHODS: In cells cultured with and without bezafibrate, intra- and extracellular fibrinogen was quantified using an enzyme-linked immunosorbent assay (ELISA), and changes in the biosynthesis and secretion of bezafibrate were monitored by [35S]-methionine labelling. Bezafibrate 44-55 fibrinogen beta chain Homo sapiens 82-92 9541130-8 1998 CONCLUSION: Apparently, bezafibrate interferes with the biosynthesis of fibrinogen at the pretranslational level but does not affect the export of the protein. Bezafibrate 24-35 fibrinogen beta chain Homo sapiens 72-82 9475863-4 1998 Atropine significantly reduced the volume of returned lavage fluids and their lysozyme content but increased their albumin and fibrinogen content. Atropine 0-8 fibrinogen beta chain Homo sapiens 127-137 9493596-6 1998 The microvesicles formed after stimulation of platelets by SFLLRN or A23187 clearly bound the soluble, biotinylated fibrinogen. Calcimycin 69-75 fibrinogen beta chain Homo sapiens 116-126 9493574-10 1998 Thromboxane excretion was positively related to fibrinogen levels and leukocyte counts (p <0.01 for both). Thromboxanes 0-11 fibrinogen beta chain Homo sapiens 48-58 9435321-5 1998 In contrast, platelets exposed to high shear rate after activation by exogenous agonists such as ADP and epinephrine can aggregate when fibrinogen is the alphaIIbbeta3 adhesive ligand, yet only if vWf binding to glycoprotein Ibalpha can also occur. Adenosine Diphosphate 97-100 fibrinogen beta chain Homo sapiens 136-146 9435321-5 1998 In contrast, platelets exposed to high shear rate after activation by exogenous agonists such as ADP and epinephrine can aggregate when fibrinogen is the alphaIIbbeta3 adhesive ligand, yet only if vWf binding to glycoprotein Ibalpha can also occur. Epinephrine 105-116 fibrinogen beta chain Homo sapiens 136-146 9456225-1 1998 Heparin induced extracorporeal lipoprotein fibrinogen precipitation (HELP) is an established procedure for removal of low-density lipoprotein (LDL) cholesterol, lipoprotein (a), and fibrinogen in patients with severe hypercholesterolemia. Heparin 0-7 fibrinogen beta chain Homo sapiens 43-53 9460990-8 1998 Collectively, these data show that N-methylformamide modulates the expression of some adhesion receptors, cell adhesion to laminin, collagen I, vitronectin and fibrinogen as well as the metastatic behaviour of M14 cells. methylformamide 35-52 fibrinogen beta chain Homo sapiens 160-170 9456225-1 1998 Heparin induced extracorporeal lipoprotein fibrinogen precipitation (HELP) is an established procedure for removal of low-density lipoprotein (LDL) cholesterol, lipoprotein (a), and fibrinogen in patients with severe hypercholesterolemia. Heparin 0-7 fibrinogen beta chain Homo sapiens 182-192 9456225-5 1998 Heparin was omitted from the precipitating buffer to avoid fibrinogen depletion in patients at risk (low fibrinogen, postoperative). Heparin 0-7 fibrinogen beta chain Homo sapiens 59-69 18370543-12 1998 CONCLUSIONS: Atorvastatin in equipotent doses to simvastatin appeared to be more effective than the latter in reducing triglyceride and plasma fibrinogen in patients with hypercholesterolaemia, mainly in those with Frederickson"s phenotype Iib. Atorvastatin 13-25 fibrinogen beta chain Homo sapiens 143-153 9865467-0 1998 Ser752 mutation to Pro or Ala in the beta3 integrin subunit differentially affects the kinetics of cell spreading to von Willebrand factor and fibrinogen. Proline 19-22 fibrinogen beta chain Homo sapiens 143-153 9865467-0 1998 Ser752 mutation to Pro or Ala in the beta3 integrin subunit differentially affects the kinetics of cell spreading to von Willebrand factor and fibrinogen. Alanine 26-29 fibrinogen beta chain Homo sapiens 143-153 9493069-2 1998 Water soluble polymer (PEG Mw = 20 KD) beads of 100-150 microns were added (12% by volume) to the fibrinogen to obtain a porous and rough structure. Water 0-5 fibrinogen beta chain Homo sapiens 98-108 9704200-3 1998 Phenylbutazone delayed the postoperative rise of fibrinogen concentration and reduced the plasminogen level on the first day after surgery. Phenylbutazone 0-14 fibrinogen beta chain Homo sapiens 49-59 9885366-0 1998 High doses of methylene blue/light treatment crosslink the A-alpha-subunit of fibrinogen: influence of this photooxidization on fibrinogen binding to platelets. Methylene Blue 14-28 fibrinogen beta chain Homo sapiens 78-88 9885366-0 1998 High doses of methylene blue/light treatment crosslink the A-alpha-subunit of fibrinogen: influence of this photooxidization on fibrinogen binding to platelets. Methylene Blue 14-28 fibrinogen beta chain Homo sapiens 128-138 9885366-7 1998 Fibrinogen treated with high doses of MB (50 microM) showed a weaker binding to the fibrinogen receptor (GP IIb/IIIa) on the platelet surface and a decrease in platelet aggregation after stimulation with ADP and photooxidized fibrinogen. Adenosine Diphosphate 204-207 fibrinogen beta chain Homo sapiens 0-10 10681808-0 1998 [Effects of lotensin and nitrendipine on plasma fibrinogen and platelet aggregation in hypertensive patients]. benazepril 12-20 fibrinogen beta chain Homo sapiens 48-58 10681808-0 1998 [Effects of lotensin and nitrendipine on plasma fibrinogen and platelet aggregation in hypertensive patients]. Nitrendipine 25-37 fibrinogen beta chain Homo sapiens 48-58 9801927-0 1998 Effect of low-dose heparin on fibrinogen levels in patients with chronic ischemic heart disease. Heparin 19-26 fibrinogen beta chain Homo sapiens 30-40 9801927-6 1998 At the end of the treatment period with low-dose heparin significant decreases in the plasma fibrinogen (2.5 +/- 0.6 g/l vs. 3.3 +/- 0.5 g/l, P < 0.001), prothrombin fragment 1 + 2 (1.4 +/- 0.5 nmol/l vs. 1.9 +/- 0.7 nmol/l, P < 0.001), thrombinantithrombin (4.5 +/- 2.4 ng/ml vs. 9.7 +/- 3.6 ng/ml, P < 0.001), and fibrinopeptide A (2.1 +/- 1.1 ng/ml vs. 3.5 +/- 2.1 ng/ml, P < 0.001) were observed compared with the period without heparin. Heparin 49-56 fibrinogen beta chain Homo sapiens 93-103 9801927-7 1998 The present results indicate that low-dose heparin can effectively control the increased abnormal thrombin generation and elevated fibrinogen levels in patients with ischemic heart disease, possibly decreasing the risk of cardiovascular death. Heparin 43-50 fibrinogen beta chain Homo sapiens 131-141 9429100-8 1998 The amount of the adsorption of albumin and fibrinogen decreased with increasing graft amount and heparin content. Heparin 98-105 fibrinogen beta chain Homo sapiens 44-54 9493069-2 1998 Water soluble polymer (PEG Mw = 20 KD) beads of 100-150 microns were added (12% by volume) to the fibrinogen to obtain a porous and rough structure. Polymers 14-21 fibrinogen beta chain Homo sapiens 98-108 9671169-7 1998 In this assay, activated human platelets are incubated with biotinylated fibrinogen (Fb-biotin) followed by antibiotin-FITC.The extent of Fb binding is determined using flow cytometric analysis. Biotin 60-66 fibrinogen beta chain Homo sapiens 73-83 9747989-7 1998 we found that the anticoagulant activity of poly(GEMA)-sulfate is due primarily to the formation of an insoluble complex with fibrinogen. poly(glucosyloxyethyl methacrylate) sulfate 44-62 fibrinogen beta chain Homo sapiens 126-136 9806446-0 1998 Rapid postadsorptive changes in fibrinogen adsorbed from plasma to segmented polyurethanes. Polyurethanes 77-90 fibrinogen beta chain Homo sapiens 32-42 9671169-7 1998 In this assay, activated human platelets are incubated with biotinylated fibrinogen (Fb-biotin) followed by antibiotin-FITC.The extent of Fb binding is determined using flow cytometric analysis. Biotin 60-66 fibrinogen beta chain Homo sapiens 85-87 9671169-7 1998 In this assay, activated human platelets are incubated with biotinylated fibrinogen (Fb-biotin) followed by antibiotin-FITC.The extent of Fb binding is determined using flow cytometric analysis. Biotin 60-66 fibrinogen beta chain Homo sapiens 138-140 9671169-8 1998 Our results indicate that Fb-biotin binds rapidly to activated platelets and its detection is dependent on incubation temperature. Biotin 29-35 fibrinogen beta chain Homo sapiens 26-28 9671169-9 1998 Platelets that were pre-incubated with the GPIIb-IIIa antagonist echistatin were inhibited from binding Fb-biotin in a concentration-dependent manner. Biotin 107-113 fibrinogen beta chain Homo sapiens 104-106 10181370-4 1998 Ethanol and ammonium sulfate precipitation of fibrinogen concentrate allow use of autologous blood and fast preparation (less than 90 minutes). Ammonium Sulfate 12-28 fibrinogen beta chain Homo sapiens 46-56 9587911-0 1998 [Coefficient of linear correlation between levels of fibrinogen, antithrombin III, thrombin-antithrombin complex and lipid fractions in women exposed chronically to carbon disulfide]. Carbon Disulfide 165-181 fibrinogen beta chain Homo sapiens 53-63 10608044-0 1998 Prothrombotic Consequences of the Oxidation of Fibrinogen and their Inhibition by Aspirin. Aspirin 82-89 fibrinogen beta chain Homo sapiens 47-57 10608044-2 1998 Aspirin can nonenzymatically acetylate fibrinogen"s lysine residues, the functional groups most susceptible to oxidative modification. Aspirin 0-7 fibrinogen beta chain Homo sapiens 39-49 10608044-2 1998 Aspirin can nonenzymatically acetylate fibrinogen"s lysine residues, the functional groups most susceptible to oxidative modification. Lysine 52-58 fibrinogen beta chain Homo sapiens 39-49 10608044-4 1998 We exposed fibrinogen to Fe(3+) ascorbate for 1 hour and showed that the carbonyl/protein molar ratio increased from 0.71 +/- 0.18 to 2.86 +/- 0.50 mol carbonyl/mol protein (P < 0.02) with an accompanying reduction in the alpha-helical content of the protein from 34% to 29%. iron(III)-ascorbic acid complex 25-41 fibrinogen beta chain Homo sapiens 11-21 10608044-5 1998 Exposure of fibrinogen to aspirin led to acetylation of lysine residues and inhibition of oxidation. Aspirin 26-33 fibrinogen beta chain Homo sapiens 12-22 10608044-5 1998 Exposure of fibrinogen to aspirin led to acetylation of lysine residues and inhibition of oxidation. Lysine 56-62 fibrinogen beta chain Homo sapiens 12-22 10608044-10 1998 These data show that oxidized fibrinogen manifests prothrombotic effects that can be prevented by acetylation and suggest that inhibition of fibrinogen oxidation may be an additional antithrombotic benefit of aspirin therapy. Aspirin 209-216 fibrinogen beta chain Homo sapiens 30-40 10608044-10 1998 These data show that oxidized fibrinogen manifests prothrombotic effects that can be prevented by acetylation and suggest that inhibition of fibrinogen oxidation may be an additional antithrombotic benefit of aspirin therapy. Aspirin 209-216 fibrinogen beta chain Homo sapiens 141-151 9576429-0 1998 Inhaled nitric oxide inhibits human platelet aggregation, P-selectin expression, and fibrinogen binding in vitro and in vivo. Nitric Oxide 8-20 fibrinogen beta chain Homo sapiens 85-95 9949790-3 1998 Moderate alcohol consumption may affect several haemostatic factors, including fibrinogen concentration, platelet aggregability and the fibrinolytic factors tissue-type plasminogen activator and plasminogen activator inhibitor. Alcohols 9-16 fibrinogen beta chain Homo sapiens 79-89 9616708-0 1997 Fibrinogen-dependent adherence of macrophages to surfaces coated with poly(ethylene oxide)/poly(propylene oxide) triblock copolymers. Polyethylene Glycols 70-90 fibrinogen beta chain Homo sapiens 0-10 16793707-5 1998 Platelets in the aggregates that formed, underwent rapid disaggregation on addition of EDTA or a GpIIb-IIIa antagonist such as MK-852 and GR144053F, all of which are agents that interfere with the ability of fibrinogen to interact with GpIIb-IIIa. Edetic Acid 87-91 fibrinogen beta chain Homo sapiens 208-218 16793707-5 1998 Platelets in the aggregates that formed, underwent rapid disaggregation on addition of EDTA or a GpIIb-IIIa antagonist such as MK-852 and GR144053F, all of which are agents that interfere with the ability of fibrinogen to interact with GpIIb-IIIa. MK 0852 127-133 fibrinogen beta chain Homo sapiens 208-218 9436179-7 1998 Thus, sulodexide releases tissue plasminogen activator and decreases fibrinogen levels as well as HDL and total cholesterol levels and blood viscosity. glucuronyl glucosamine glycan sulfate 6-16 fibrinogen beta chain Homo sapiens 69-79 9616708-0 1997 Fibrinogen-dependent adherence of macrophages to surfaces coated with poly(ethylene oxide)/poly(propylene oxide) triblock copolymers. poly(propylene oxide) triblock copolymers 91-132 fibrinogen beta chain Homo sapiens 0-10 9616708-1 1997 The role of fibrinogen in the adherence of macrophages to polymer surfaces was studied using a human cell line (THP-1 cells) and polystyrene-divinylbenzene beads coated with poly(ethylene oxide)/poly(propylene oxide) copolymers of the form PEO alpha PPO beta PEO alpha. Polymers 58-65 fibrinogen beta chain Homo sapiens 12-22 9616708-4 1997 The adherence of THP-1 cells to copolymer-coated beads correlates well with the amount of fibrinogen bound to the beads. copolymer 32-41 fibrinogen beta chain Homo sapiens 90-100 9629332-4 1997 The fibrinogen mean value was 269 mg/dl in gl and 353 mg/dl in g2. glycylleucine 43-45 fibrinogen beta chain Homo sapiens 4-14 9459351-6 1998 The broad inhibition spectrum could be explained by the capacity of piracetam to prevent fibrinogen binding to activated human platelets. Piracetam 68-77 fibrinogen beta chain Homo sapiens 89-99 9368136-0 1997 Effect of single-chain and two-chain high molecular weight kininogen on adsorption of fibrinogen from binary mixtures to glass and sulfonated polyurethane surfaces. Polyurethanes 142-154 fibrinogen beta chain Homo sapiens 86-96 9368136-1 1997 The adsorption of fibrinogen from a single protein solution and from binary mixtures of fibrinogen and high-molecular-weight kininogen (HK) to glass and four sulfonated polyurethane surfaces is reported. Polyurethanes 169-181 fibrinogen beta chain Homo sapiens 18-28 9368136-6 1997 Polyacrylamide gel electrophoresis and immunoblotting analysis of the proteins eluted from the surfaces after contact with the fibrinogen-SCHK solutions indicated that although intact SCHK was essentially conserved, some transformation of SCHK to TCHK on the surface occurred during the course of the experiment. polyacrylamide 0-14 fibrinogen beta chain Homo sapiens 127-137 9416855-0 1997 Increased phosphate content in complement component C3, fibrinogen, vitronectin, and other plasma proteins in systemic lupus erythematosus: covariation with platelet activation and possible association with thrombosis. Phosphates 10-19 fibrinogen beta chain Homo sapiens 56-66 9416855-10 1997 Substantial phosphate increases were seen in C3 and fibrinogen. Phosphates 12-21 fibrinogen beta chain Homo sapiens 52-62 9416855-12 1997 CONCLUSION: In SLE patients, the phosphate content in plasma proteins (including C3 and fibrinogen) increases due to platelet activation. Phosphates 33-42 fibrinogen beta chain Homo sapiens 88-98 9401066-3 1997 Analysis of purified fibrinogen on reducing SDS-PAGE revealed an additional band, in all family members, which migrated immediately below the normal B beta band. Sodium Dodecyl Sulfate 44-47 fibrinogen beta chain Homo sapiens 21-31 9523019-0 1997 Echistatin inhibits pp72syk and pp125FAK phosphorylation in fibrinogen-adherent platelets. echistatin 0-10 fibrinogen beta chain Homo sapiens 60-70 9401066-10 1997 Further analysis of the D domain of purified fibrinogen established that calcium binding to the high affinity site remained unaffected by the bulky carbohydrate side chain or negatively charged sialic acid residues. Calcium 73-80 fibrinogen beta chain Homo sapiens 45-55 9523019-1 1997 The adhesion of ADP-stimulated platelets to immobilized fibrinogen induces the tyrosine phosphorylation of multiple proteins which include pp72syk and pp125FAK. Adenosine Diphosphate 16-19 fibrinogen beta chain Homo sapiens 56-66 9523019-1 1997 The adhesion of ADP-stimulated platelets to immobilized fibrinogen induces the tyrosine phosphorylation of multiple proteins which include pp72syk and pp125FAK. Tyrosine 79-87 fibrinogen beta chain Homo sapiens 56-66 9308746-10 1997 A negative correlation was seen between the area under the curve of tcu-PA activity and the areas under the effect curves of both fibrinogen and alpha2-antiplasmin (r = -0.84; p <0.01 and r = -0.65; p <0.05). tcu-pa 68-74 fibrinogen beta chain Homo sapiens 130-140 9523019-4 1997 Echistatin, an Arg-Gly-Asp (RGD)-containing snake-venom protein, affects protein tyrosine phosphorylation promoted by platelet adhesion to fibrinogen, by causing an approximately 44% and 39% decrease of pp72syk and pp125FAK phosphorylation, respectively. echistatin 0-10 fibrinogen beta chain Homo sapiens 139-149 9423799-0 1997 Electrospray ionisation mass spectrometry facilitates detection of fibrinogen (Bbeta 14 Arg --> Cys) mutation in a family with thrombosis. Arginine 88-91 fibrinogen beta chain Homo sapiens 67-77 9423799-0 1997 Electrospray ionisation mass spectrometry facilitates detection of fibrinogen (Bbeta 14 Arg --> Cys) mutation in a family with thrombosis. Cysteine 99-102 fibrinogen beta chain Homo sapiens 67-77 9368024-0 1997 Severely impaired polymerization of recombinant fibrinogen gamma-364 Asp --> His, the substitution discovered in a heterozygous individual. Aspartic Acid 69-72 fibrinogen beta chain Homo sapiens 48-58 9386091-1 1997 BACKGROUND: A combined treatment of statins and extracorporeal H.E.L.P.-apheresis (Heparin-mediated Extracorporeal LDL/fibrinogen Precipitation) has already been shown to be beneficial for coronary artery disease (CAD). Heparin 83-90 fibrinogen beta chain Homo sapiens 119-129 9409328-5 1997 Baseline plasma fibrinogen was independently related to risk of stroke in multivariate analysis that adjusted for cigarette smoking, LDL-cholesterol, systolic blood pressure, and preexisting IHD (relative risk [RR] 1.52, 95% confidence interval [CI] 1.17, 1.98). Cholesterol 137-148 fibrinogen beta chain Homo sapiens 16-26 9768470-6 1997 Purified human fibrinogen, together with 15-nm colloidal gold particles serving as an internal calibration standard, were adhered to a poly-L-lysine substrate on freshly cleaved mica. Lysine 135-148 fibrinogen beta chain Homo sapiens 15-25 9768470-6 1997 Purified human fibrinogen, together with 15-nm colloidal gold particles serving as an internal calibration standard, were adhered to a poly-L-lysine substrate on freshly cleaved mica. mica 178-182 fibrinogen beta chain Homo sapiens 15-25 9361377-10 1997 It is well known that argatroban inhibits not only thrombin cleavage of fibrinogen with a Ki of 19 nM, but also thrombin-mediated platelet activation with a Ki of 40 nM [4]. argatroban 22-32 fibrinogen beta chain Homo sapiens 72-82 9381994-0 1997 Comparison of bezafibrate versus lovastatin for lowering plasma insulin, fibrinogen, and plasminogen activator inhibitor-1 concentrations in hyperlipemic heart transplant patients. Bezafibrate 14-25 fibrinogen beta chain Homo sapiens 73-83 9326231-1 1997 Lung epithelial cells (A549) synthesize and secrete fibrinogen (FBG) in vitro when stimulated with interleukin-6 and dexamethasone. Dexamethasone 117-130 fibrinogen beta chain Homo sapiens 52-62 9326231-1 1997 Lung epithelial cells (A549) synthesize and secrete fibrinogen (FBG) in vitro when stimulated with interleukin-6 and dexamethasone. Dexamethasone 117-130 fibrinogen beta chain Homo sapiens 64-67 9326231-10 1997 Cell surface-bound FBG is initially deoxycholate-soluble, which, over time, becomes incorporated in the deoxycholate-insoluble ECM in a similar fashion to FN. Deoxycholic Acid 36-48 fibrinogen beta chain Homo sapiens 19-22 9326231-10 1997 Cell surface-bound FBG is initially deoxycholate-soluble, which, over time, becomes incorporated in the deoxycholate-insoluble ECM in a similar fashion to FN. Deoxycholic Acid 104-116 fibrinogen beta chain Homo sapiens 19-22 9357508-3 1997 According to an early model suggested by Browse and Burnand, pericapillary fibrin cuffs, developing as a result of venous hypertension and extravasation of fibrinogen, act as a barrier to the diffusion of oxygen and nutrients; ultimately, tissue anoxia, cell death, and ulceration would follow. Oxygen 205-211 fibrinogen beta chain Homo sapiens 156-166 9364979-0 1997 Effects of gemfibrozil and ciprofibrate on plasma levels of tissue-type plasminogen activator, plasminogen activator inhibitor-1 and fibrinogen in hyperlipidaemic patients. ciprofibrate 27-39 fibrinogen beta chain Homo sapiens 133-143 9364979-6 1997 Fibrinogen antigen levels were elevated by 17.6% (p <0.05) and 24.3% (p <0.001) with gemfibrozil after six and twelve weeks, respectively, whereas with ciprofibrate there was no effect. Gemfibrozil 91-102 fibrinogen beta chain Homo sapiens 0-10 9364979-6 1997 Fibrinogen antigen levels were elevated by 17.6% (p <0.05) and 24.3% (p <0.001) with gemfibrozil after six and twelve weeks, respectively, whereas with ciprofibrate there was no effect. ciprofibrate 158-170 fibrinogen beta chain Homo sapiens 0-10 9364979-8 1997 However, after twelve weeks, gemfibrozil enhanced functional fibrinogen levels by 7.2% (p <0.05) as assessed by the Clauss mechanical assay, but decreased functional fibrinogen levels by 12.5% (p <0.0001) when a Clauss assay based on turbidity was used. Gemfibrozil 29-40 fibrinogen beta chain Homo sapiens 61-71 9364979-8 1997 However, after twelve weeks, gemfibrozil enhanced functional fibrinogen levels by 7.2% (p <0.05) as assessed by the Clauss mechanical assay, but decreased functional fibrinogen levels by 12.5% (p <0.0001) when a Clauss assay based on turbidity was used. Gemfibrozil 29-40 fibrinogen beta chain Homo sapiens 169-179 9364979-9 1997 After six or twelve weeks of ciprofibrate treatment, functional fibrinogen levels were decreased by 10.1% (p <0.001) and 10.5% (p <0.0001), respectively on the basis of Clauss mechanical and by 14.2% (p <0.001) and 28.2% (p <0.0001), respectively with the Clauss turbidimetric assay. ciprofibrate 29-41 fibrinogen beta chain Homo sapiens 64-74 9295325-0 1997 The polymerization pocket "a" within the carboxyl-terminal region of the gamma chain of human fibrinogen is adjacent to but independent from the calcium-binding site. Calcium 145-152 fibrinogen beta chain Homo sapiens 94-104 9295325-1 1997 The carboxyl-terminal region of the gamma chain of fibrinogen is involved in calcium binding, fibrin polymerization, factor XIIIa-mediated cross-linking, and binding to the platelet fibrin(ogen) receptor. Calcium 77-84 fibrinogen beta chain Homo sapiens 51-61 9294990-12 1997 Simvastatin + ciprofibrate was more effective than pravastatin + gemfibrozil in reducing LDL, TG, and plasma fibrinogen levels. Simvastatin 0-11 fibrinogen beta chain Homo sapiens 109-119 9294990-12 1997 Simvastatin + ciprofibrate was more effective than pravastatin + gemfibrozil in reducing LDL, TG, and plasma fibrinogen levels. ciprofibrate 14-26 fibrinogen beta chain Homo sapiens 109-119 9294990-12 1997 Simvastatin + ciprofibrate was more effective than pravastatin + gemfibrozil in reducing LDL, TG, and plasma fibrinogen levels. Pravastatin 51-62 fibrinogen beta chain Homo sapiens 109-119 9294990-12 1997 Simvastatin + ciprofibrate was more effective than pravastatin + gemfibrozil in reducing LDL, TG, and plasma fibrinogen levels. Gemfibrozil 65-76 fibrinogen beta chain Homo sapiens 109-119 9303166-6 1997 CONCLUSIONS: Because it is made from pooled-donor blood that has been treated with virus elimination procedures, FS is superior to autologous fibrin tissue adhesive in which fibrinogen is precipitated by the ethanol/freezing method. Ethanol 208-215 fibrinogen beta chain Homo sapiens 174-184 9314913-0 1997 Fibrinogen and plasminogen modifications during oral estradiol replacement therapy. Estradiol 53-62 fibrinogen beta chain Homo sapiens 0-10 9299092-0 1997 Sequential Adsorption of Human Serum Albumin (HSA), Immunoglobulin G (IgG), and Fibrinogen (Fgn) at HMDSO Plasma Polymer Surfaces The sequential adsorption of human serum albumin (HSA), immunoglobulin G (IgG), and fibrinogen (Fgn) at hexamethyldisiloxane (HMDSO) plasma polymer surfaces was investigated with ellipsometry and total internal reflection fluorescence spectroscopy (TIRF) as a function of adsorption time, pH, and excess electrolyte concentration. Polymers 113-120 fibrinogen beta chain Homo sapiens 80-90 9299092-0 1997 Sequential Adsorption of Human Serum Albumin (HSA), Immunoglobulin G (IgG), and Fibrinogen (Fgn) at HMDSO Plasma Polymer Surfaces The sequential adsorption of human serum albumin (HSA), immunoglobulin G (IgG), and fibrinogen (Fgn) at hexamethyldisiloxane (HMDSO) plasma polymer surfaces was investigated with ellipsometry and total internal reflection fluorescence spectroscopy (TIRF) as a function of adsorption time, pH, and excess electrolyte concentration. Polymers 113-120 fibrinogen beta chain Homo sapiens 92-95 9299092-0 1997 Sequential Adsorption of Human Serum Albumin (HSA), Immunoglobulin G (IgG), and Fibrinogen (Fgn) at HMDSO Plasma Polymer Surfaces The sequential adsorption of human serum albumin (HSA), immunoglobulin G (IgG), and fibrinogen (Fgn) at hexamethyldisiloxane (HMDSO) plasma polymer surfaces was investigated with ellipsometry and total internal reflection fluorescence spectroscopy (TIRF) as a function of adsorption time, pH, and excess electrolyte concentration. hexamethyldisiloxane 100-105 fibrinogen beta chain Homo sapiens 92-95 9379137-2 1997 The extracellular domains of many integrins recognize the RGD (Arg-Gly-Asp) tripeptide found in several extracellular macromolecules such as fibronectin, vitronectin, fibrinogen and osteopontin. arginyl-glycyl-aspartic acid 63-74 fibrinogen beta chain Homo sapiens 167-177 9379137-2 1997 The extracellular domains of many integrins recognize the RGD (Arg-Gly-Asp) tripeptide found in several extracellular macromolecules such as fibronectin, vitronectin, fibrinogen and osteopontin. tripeptide K-26 76-86 fibrinogen beta chain Homo sapiens 167-177 9306622-7 1997 The results suggest that these new potent agents inhibit platelet phosphodiesterase activity causing an elevation in cAMP levels sufficient to inhibit calcium rise and fibrinogen binding. Cyclic AMP 117-121 fibrinogen beta chain Homo sapiens 168-178 9606832-1 1997 Heparin was studied for its effect on the hydrolysis time of clots from desAA fibrin (FB), desAABB fibrin (F0) and fibrinogen (Fg) of a bull and a man by gly-or lys-plasminogen which is activated by the tissue activator. Heparin 0-7 fibrinogen beta chain Homo sapiens 115-125 9606832-1 1997 Heparin was studied for its effect on the hydrolysis time of clots from desAA fibrin (FB), desAABB fibrin (F0) and fibrinogen (Fg) of a bull and a man by gly-or lys-plasminogen which is activated by the tissue activator. Heparin 0-7 fibrinogen beta chain Homo sapiens 127-129 9606832-1 1997 Heparin was studied for its effect on the hydrolysis time of clots from desAA fibrin (FB), desAABB fibrin (F0) and fibrinogen (Fg) of a bull and a man by gly-or lys-plasminogen which is activated by the tissue activator. Glycine 154-157 fibrinogen beta chain Homo sapiens 127-129 9606832-5 1997 In concentration 4.6 microM heparin increases the hydrolysis time of clots from human fibrinogen by fibrinolytic systems. Heparin 28-35 fibrinogen beta chain Homo sapiens 86-96 9271071-4 1997 By investigating the adsorption kinetics of fibrinogen at differently terminated self-assembled monolayers (SAMs) of alkanethiols on thin gold films, it is demonstrated that acoustic plate-mode sensors are a promising analytical tool for studying the adsorption of proteins. alkanethiols 117-129 fibrinogen beta chain Homo sapiens 44-54 9271071-5 1997 In agreement with previous studies for fibrinogen, it is shown in situ that hexa(ethylene glycol)-terminated SAMs (HS(CH2)11 (OCH2CH2)6OH) exhibit very low protein adsorption and that methyl-terminated SAMs (HS(CH2)11CH3) tend to absorb large amounts of protein nonspecifically. Ethylene Glycol 81-96 fibrinogen beta chain Homo sapiens 39-49 9242618-3 1997 Deletion of the entire Glu146-Lys149e loop, however, reduces fibrinogen clotting 240-fold, but decreases protein C activation only 2-fold. DL-Glutamic acid 23-29 fibrinogen beta chain Homo sapiens 61-71 9242618-3 1997 Deletion of the entire Glu146-Lys149e loop, however, reduces fibrinogen clotting 240-fold, but decreases protein C activation only 2-fold. lys149e 30-37 fibrinogen beta chain Homo sapiens 61-71 9325467-4 1997 Pentoxifylline (Trental 400) significantly reduced blood and plasma viscosity (at high and low shear-rates), fibrinogen and erythrocyte aggregation, and increased erythrocyte filterability throughout the study. Pentoxifylline 0-14 fibrinogen beta chain Homo sapiens 109-119 9325467-4 1997 Pentoxifylline (Trental 400) significantly reduced blood and plasma viscosity (at high and low shear-rates), fibrinogen and erythrocyte aggregation, and increased erythrocyte filterability throughout the study. Pentoxifylline 16-23 fibrinogen beta chain Homo sapiens 109-119 9296274-10 1997 Chronic treatment with calcium antagonist nilvadipine brought about significant reductions in BPs and rheological parameters of whole-blood viscosities at low and middle shear rates, corrected blood viscosity (Ht 45%) at a low shear rate, and plasma viscosity without changes in serum albumin and plasma fibrinogen levels, as compared with normotensive individuals. Calcium 23-30 fibrinogen beta chain Homo sapiens 304-314 9296274-10 1997 Chronic treatment with calcium antagonist nilvadipine brought about significant reductions in BPs and rheological parameters of whole-blood viscosities at low and middle shear rates, corrected blood viscosity (Ht 45%) at a low shear rate, and plasma viscosity without changes in serum albumin and plasma fibrinogen levels, as compared with normotensive individuals. nilvadipine 42-53 fibrinogen beta chain Homo sapiens 304-314 9231665-0 1997 Evidence for acute stimulation of fibrinogen production by glucagon in humans. Glucagon 59-67 fibrinogen beta chain Homo sapiens 34-44 9231665-3 1997 We have studied the acute effects of selective hyperglucagonemia (raised from -200 to -350 pg/ml for 3 h) on fibrinogen fractional secretion rate (FSR) in eight normal subjects during infusion of somatostatin and replacement doses of insulin, glucagon, and growth hormone. Glucagon 52-60 fibrinogen beta chain Homo sapiens 109-119 9231665-6 1997 After hyperglucagonemia, fibrinogen FSR increased by approximately 65% (from 12.9 +/- 3.6 to 21.5 +/- 6.1% per day, P < 0.025) using plasma Phe specific activity as the precursor pool. Phenylalanine 143-146 fibrinogen beta chain Homo sapiens 25-35 9231665-9 1997 In conclusion, selective hyperglucagonemia for approximately 3 h acutely stimulated fibrinogen FSR using a Phe tracer method. Phenylalanine 107-110 fibrinogen beta chain Homo sapiens 84-94 9259113-4 1997 Plasma fibrinogen levels showed a significant reduction in both groups, in patients with high basal levels (> or = 350 mg/dl), the reduction being earlier in Sdx group (2nd month of therapy) than in Ptx group (4th month of therapy). glucuronyl glucosamine glycan sulfate 161-164 fibrinogen beta chain Homo sapiens 7-17 9263400-0 1997 Sphingosine stimulates thrombin-induced gelation of the fibrinogen. Sphingosine 0-11 fibrinogen beta chain Homo sapiens 56-66 9268181-4 1997 An interaction between RsaI, which was in complete linkage disequilibrium with TaqI, and PA on plasma fibrinogen was observed, even after adjustments for BMI, smoking and medication (p = 0.024). rsai 23-27 fibrinogen beta chain Homo sapiens 102-112 9233715-5 1997 The presence of adenosine triphosphate, however, predicts a significantly better metabolic capacity to eliminate bilirubin, to synthesize fibrinogen and antithrombin III, and to maintain a better prothrombin time after transplantation. Adenosine Triphosphate 16-38 fibrinogen beta chain Homo sapiens 138-148 9259113-4 1997 Plasma fibrinogen levels showed a significant reduction in both groups, in patients with high basal levels (> or = 350 mg/dl), the reduction being earlier in Sdx group (2nd month of therapy) than in Ptx group (4th month of therapy). Pentoxifylline 202-205 fibrinogen beta chain Homo sapiens 7-17 9352095-0 1997 Metal-ion catalyzed oxidation affects fibrinogen activity on platelet aggregation and adhesion. Metals 0-5 fibrinogen beta chain Homo sapiens 38-48 9247706-3 1997 In this work, we have demonstrated that CKII and polycationic compounds such as polylysine, spermine, and spermidine synergistically stimulate thrombin-induced gelation of the fibrinogen. Polylysine 80-90 fibrinogen beta chain Homo sapiens 176-186 9247706-3 1997 In this work, we have demonstrated that CKII and polycationic compounds such as polylysine, spermine, and spermidine synergistically stimulate thrombin-induced gelation of the fibrinogen. Spermine 92-100 fibrinogen beta chain Homo sapiens 176-186 9247706-3 1997 In this work, we have demonstrated that CKII and polycationic compounds such as polylysine, spermine, and spermidine synergistically stimulate thrombin-induced gelation of the fibrinogen. Spermidine 106-116 fibrinogen beta chain Homo sapiens 176-186 9352095-3 1997 Formation of dityrosines as well as loss of tryptophan following fibrinogen oxidation were observed. Tryptophan 44-54 fibrinogen beta chain Homo sapiens 65-75 9352095-6 1997 The percentage of ADP-induced platelet aggregation decreased as a function of fibrinogen oxidative damage. Adenosine Diphosphate 18-21 fibrinogen beta chain Homo sapiens 78-88 9282789-1 1997 Fibrinogen is a complex multifunctional protein comprised of three major domains (two outer D and one central E) which contains constitutive binding sites (e.g. Da, Db, gammaXL, D:D, gamma", thrombin substrate, platelet receptor) as well as binding sites that become exposed or expressed as a result of fibrinogen proteolysis by thrombin and/or that are exposed as a consequence of the polymerization process itself (tPA binding sites). Tetradecanoylphorbol Acetate 417-420 fibrinogen beta chain Homo sapiens 0-10 9296306-5 1997 A positive correlation between blood fibrinogen and serotonin was found in the pooled hypertensive group and in the hypertensive men (p < 0.01) and between blood viscosity (shear rate 6 s-1) and neuropeptide Y in the pooled hypertensive group (p < 0.01). Serotonin 52-61 fibrinogen beta chain Homo sapiens 37-47 9282789-2 1997 Fibrin-dependent tPA-mediated activation of plasminogen is associated with exposure of polymerization-dependent epitopes (Aalpha148-160, gamma312-324) that are expressed in assembled fibrin and in crosslinked (polymerized) fibrinogen but not in unpolymerized fibrinogen or fibrin. Tetradecanoylphorbol Acetate 17-20 fibrinogen beta chain Homo sapiens 223-233 9282789-2 1997 Fibrin-dependent tPA-mediated activation of plasminogen is associated with exposure of polymerization-dependent epitopes (Aalpha148-160, gamma312-324) that are expressed in assembled fibrin and in crosslinked (polymerized) fibrinogen but not in unpolymerized fibrinogen or fibrin. Tetradecanoylphorbol Acetate 17-20 fibrinogen beta chain Homo sapiens 259-269 9182580-4 1997 The inclusion of 200-800 nM fibrinogen but not fibronectin to the culture medium of Raji induced a 2-4-fold increase in [3H]thymidine incorporation after 8 h. Cell proliferation in cultures containing fibrinogen was also confirmed by direct cell counting. Tritium 121-123 fibrinogen beta chain Homo sapiens 28-38 9249017-6 1997 Cerastotin efficiently clots human plasma and cleaves preferentially the alpha chain of fibrinogen. cerastotin 0-10 fibrinogen beta chain Homo sapiens 88-98 9249017-7 1997 Cerastotin did not induce aggregation of washed normal platelets, but did aggregate platelets in the presence of exogenous fibrinogen. cerastotin 0-10 fibrinogen beta chain Homo sapiens 123-133 9249017-13 1997 Cerastotin also agglutinates formalin-fixed and washed platelets, only in the simultaneous presence of fibrinogen and of Von Willebrand factor. cerastotin 0-10 fibrinogen beta chain Homo sapiens 103-113 9199447-4 1997 Purified human fibrinogen and peptides containing the sequence Arg-Gly-Asp (RGD) were also found to promote bacterial invasion of cultured cells. Arginine 63-66 fibrinogen beta chain Homo sapiens 15-25 9199447-4 1997 Purified human fibrinogen and peptides containing the sequence Arg-Gly-Asp (RGD) were also found to promote bacterial invasion of cultured cells. Glycine 67-70 fibrinogen beta chain Homo sapiens 15-25 9199447-4 1997 Purified human fibrinogen and peptides containing the sequence Arg-Gly-Asp (RGD) were also found to promote bacterial invasion of cultured cells. Aspartic Acid 71-74 fibrinogen beta chain Homo sapiens 15-25 9199447-6 1997 Invasion stimulation did not appear to involve de novo synthesis of a bacterial protein, as FCS and fibrinogen stimulated invasion in the presence of chloramphenicol. Chloramphenicol 150-165 fibrinogen beta chain Homo sapiens 100-110 9182580-4 1997 The inclusion of 200-800 nM fibrinogen but not fibronectin to the culture medium of Raji induced a 2-4-fold increase in [3H]thymidine incorporation after 8 h. Cell proliferation in cultures containing fibrinogen was also confirmed by direct cell counting. Tritium 121-123 fibrinogen beta chain Homo sapiens 201-211 9182580-7 1997 200 nM fibrinogen induced a 3-fold increase in [3H]thymidine incorporation by 293 cells transfected with ICAM-1 cDNA but not control non-transfected 293 cells. Tritium 48-50 fibrinogen beta chain Homo sapiens 7-17 9182580-7 1997 200 nM fibrinogen induced a 3-fold increase in [3H]thymidine incorporation by 293 cells transfected with ICAM-1 cDNA but not control non-transfected 293 cells. Thymidine 51-60 fibrinogen beta chain Homo sapiens 7-17 9182584-4 1997 Binding of phosphacan and neurocan to intact tenascin-C, and of phosphacan to the fibrinogen globe, is significantly increased in the presence of calcium. Calcium 146-153 fibrinogen beta chain Homo sapiens 82-92 9199274-8 1997 On stratification of the subjects into 4 quartiles based on plasma fibrinogen concentrations, we found that increased plasma fibrinogen was associated with older age, higher body mass index (BMI), systolic and diastolic blood pressure (BP), fasting and 2 h plasma glucose (PG), prevalence of diabetes, glycated haemoglobin (HbA1c) and triglyceride (TG) level. Glucose 264-271 fibrinogen beta chain Homo sapiens 125-135 9199274-8 1997 On stratification of the subjects into 4 quartiles based on plasma fibrinogen concentrations, we found that increased plasma fibrinogen was associated with older age, higher body mass index (BMI), systolic and diastolic blood pressure (BP), fasting and 2 h plasma glucose (PG), prevalence of diabetes, glycated haemoglobin (HbA1c) and triglyceride (TG) level. Triglycerides 335-347 fibrinogen beta chain Homo sapiens 125-135 9199274-8 1997 On stratification of the subjects into 4 quartiles based on plasma fibrinogen concentrations, we found that increased plasma fibrinogen was associated with older age, higher body mass index (BMI), systolic and diastolic blood pressure (BP), fasting and 2 h plasma glucose (PG), prevalence of diabetes, glycated haemoglobin (HbA1c) and triglyceride (TG) level. Triglycerides 349-351 fibrinogen beta chain Homo sapiens 125-135 9199274-9 1997 After adjustment for age and sex, increased plasma fibrinogen concentration remained associated with higher BMI, systolic BP, 2 h PG and TG level. Triglycerides 137-139 fibrinogen beta chain Homo sapiens 51-61 9199274-10 1997 On multivariate analysis using age, BMI, BP, TG, HbA1c and PG as independent variables, plasma fibrinogen was independently related to plasma TG concentration and HbA1c. Triglycerides 45-47 fibrinogen beta chain Homo sapiens 95-105 9199274-12 1997 change in TG concentration and HbA1c, there were 3.7 and 5.2% changes in plasma fibrinogen concentration respectively. Triglycerides 10-12 fibrinogen beta chain Homo sapiens 80-90 9199274-13 1997 These findings emphasize the close relationships between plasma fibrinogen and cardiovascular risk factors, in particular abnormal lipid and glucose metabolism. Glucose 141-148 fibrinogen beta chain Homo sapiens 64-74 9217177-5 1997 Serum cholesterol and triglyceride were associated with increases in factors VII and IX, as well as antithrombin, protein C and protein S; and with increased fibrinogen and factor VIII in women. Cholesterol 6-17 fibrinogen beta chain Homo sapiens 158-168 9264319-1 1997 The effect on human platelets of 2-(1-piperazinyl)-4H-pyrido[1,2-a]pyrimi din-4-one (AP155) was tested in vitro by measuring cyclic adenosine monophosphate (cAMP) level, cytosolic Ca++, [(125I)]fibrinogen binding as well as aggregation induced by several agonists. AP 155 33-83 fibrinogen beta chain Homo sapiens 194-204 9264319-4 1997 AP155 was able to inhibit aggregation, the increase in cytosolic Ca++ induced by thrombin, and fibrinogen binding to ADP or thrombin-stimulated platelets. Adenosine Diphosphate 117-120 fibrinogen beta chain Homo sapiens 95-105 9217177-5 1997 Serum cholesterol and triglyceride were associated with increases in factors VII and IX, as well as antithrombin, protein C and protein S; and with increased fibrinogen and factor VIII in women. Triglycerides 22-34 fibrinogen beta chain Homo sapiens 158-168 9217177-7 1997 Smoking status and/or smoking markers were related to fibrinogen, factor IX, antithrombin and protein S. Alcohol intake was related to protein S, and inversely to fibrinogen and antithrombin in men. Alcohols 105-112 fibrinogen beta chain Homo sapiens 163-173 9222650-5 1997 There was a clustering of vascular risk factors, with a positive relationship between plasma fibrinogen and serum triglyceride concentrations in both genders and between fibrinogen and total cholesterol in males. Triglycerides 114-126 fibrinogen beta chain Homo sapiens 93-103 9157941-4 1997 Linoleic acid, which is the most abundant polyunsaturated fatty acid, was negatively associated with plasminogen and fibrinogen. Linoleic Acid 0-13 fibrinogen beta chain Homo sapiens 117-127 9192939-7 1997 In contrast, DTT-treated sputum had higher total cell counts (median 8.8 vs 2.8 x 10(6) mL(-1); p<0.001) and levels of ECP (median 1340 vs 584 mg x L(-1); p<0.001) The measurements were similar with respect to the proportion of eosinophils, neutrophils, lymphocytes, macrophages, and fluid-phase fibrinogen, IL-5 and IL-8. Dithiothreitol 13-16 fibrinogen beta chain Homo sapiens 302-312 9475670-0 1997 Nicotinic acid treatment shifts the fibrinolytic balance favourably and decreases plasma fibrinogen in hypertriglyceridaemic men. Niacin 0-14 fibrinogen beta chain Homo sapiens 89-99 9475670-10 1997 CONCLUSION: This study of hypertriglyceridaemic men has shown that long-term treatment with nicotinic acid not only corrects serum lipoprotein abnormalities, but also reduces the fibrinogen concentration in plasma and stimulates fibrinolysis. Niacin 92-106 fibrinogen beta chain Homo sapiens 179-189 9157941-4 1997 Linoleic acid, which is the most abundant polyunsaturated fatty acid, was negatively associated with plasminogen and fibrinogen. Fatty Acids, Unsaturated 42-68 fibrinogen beta chain Homo sapiens 117-127 9157941-7 1997 Furthermore, dihomogammalinolenic acid was positively and significantly associated with FVII:C, fibrinogen, and plasminogen among women but not among men. 8,11,14-Eicosatrienoic Acid 13-38 fibrinogen beta chain Homo sapiens 96-106 9303865-1 1997 We prospectively studied the fibrinogen plasma levels of patients with acute myocardial infarction (AMI) and unstable angina (UA) whose diagnosis was based on clinical, electrocardiographical, enzymatic or pirophosphate scintigraphy data. pirophosphate 206-219 fibrinogen beta chain Homo sapiens 29-39 9184383-10 1997 However, there was a marked decrease in fibrinogen level (about 50%) when the plasma was incubated for five min with a very high concentration of RSTA. rsta 146-150 fibrinogen beta chain Homo sapiens 40-50 9184396-1 1997 Human plasma fibrinogen is heterogeneous in SDS-polyacrylamide gel electrophoresis and other methods for separation of proteins by molecular size. Sodium Dodecyl Sulfate 44-47 fibrinogen beta chain Homo sapiens 13-23 9265236-24 1997 It is possible that the presence of fibrinogen and some coagulation factors disturb the polyethylenglycol precipitation mechanism. polyethylenglycol 88-105 fibrinogen beta chain Homo sapiens 36-46 9184396-1 1997 Human plasma fibrinogen is heterogeneous in SDS-polyacrylamide gel electrophoresis and other methods for separation of proteins by molecular size. polyacrylamide 48-62 fibrinogen beta chain Homo sapiens 13-23 9184396-5 1997 Fibrinogen was detected by specific immunostaining of nonreduced SDS-PAGE gel immunoblots with antibodies against fibrinopeptide A. Sodium Dodecyl Sulfate 65-68 fibrinogen beta chain Homo sapiens 0-10 9184398-8 1997 As concerning the effect of alcohol intake status, Fbg had a tendency to decrease with alcohol intake. Alcohols 28-35 fibrinogen beta chain Homo sapiens 51-54 9184398-8 1997 As concerning the effect of alcohol intake status, Fbg had a tendency to decrease with alcohol intake. Alcohols 87-94 fibrinogen beta chain Homo sapiens 51-54 9184398-11 1997 Fbg was positively correlated with age, systolic blood pressure, diastolic blood pressure, total cholesterol, LDL-cholesterol and triglycerides in women, but Fbg had few positive correlations with risk factors in men. Cholesterol 97-108 fibrinogen beta chain Homo sapiens 0-3 9184398-11 1997 Fbg was positively correlated with age, systolic blood pressure, diastolic blood pressure, total cholesterol, LDL-cholesterol and triglycerides in women, but Fbg had few positive correlations with risk factors in men. Cholesterol 114-125 fibrinogen beta chain Homo sapiens 0-3 9184398-11 1997 Fbg was positively correlated with age, systolic blood pressure, diastolic blood pressure, total cholesterol, LDL-cholesterol and triglycerides in women, but Fbg had few positive correlations with risk factors in men. Triglycerides 130-143 fibrinogen beta chain Homo sapiens 0-3 9168936-7 1997 Flow cytometric analysis revealed that platelets stimulated with 10 mumol/L ADP at 108 dyne/cm2 bound fluorescein isothiocyanate (FITC)-labeled fibrinogen, although aggregation was absent in this experimental condition. Adenosine Diphosphate 76-79 fibrinogen beta chain Homo sapiens 144-154 9168936-7 1997 Flow cytometric analysis revealed that platelets stimulated with 10 mumol/L ADP at 108 dyne/cm2 bound fluorescein isothiocyanate (FITC)-labeled fibrinogen, although aggregation was absent in this experimental condition. Fluorescein-5-isothiocyanate 102-128 fibrinogen beta chain Homo sapiens 144-154 9168936-7 1997 Flow cytometric analysis revealed that platelets stimulated with 10 mumol/L ADP at 108 dyne/cm2 bound fluorescein isothiocyanate (FITC)-labeled fibrinogen, although aggregation was absent in this experimental condition. Fluorescein-5-isothiocyanate 130-134 fibrinogen beta chain Homo sapiens 144-154 9128326-5 1997 nafamostat mesilate and underwent selective embolization of the arteries feeding the hemangioma; consequently, the plasma fibrinogen concentration increased to 1.6-fold before surgery. nafamostat 0-19 fibrinogen beta chain Homo sapiens 122-132 9187410-6 1997 PAI-1, FVII and fibrinogen levels were significantly correlated with the degree of insulin resistance estimated by the steady state plasma glucose concentration (SSPG) during the continuous infusion of glucose, insulin and octreotide. Glucose 139-146 fibrinogen beta chain Homo sapiens 16-26 9146854-3 1997 RESULTS: In the presence of fibrinogen (300 micrograms ml-1) both collagen (5 micrograms ml-1) and adrenaline (16 microM) stimulated the aggregation of washed platelets. Epinephrine 99-109 fibrinogen beta chain Homo sapiens 28-38 9187410-6 1997 PAI-1, FVII and fibrinogen levels were significantly correlated with the degree of insulin resistance estimated by the steady state plasma glucose concentration (SSPG) during the continuous infusion of glucose, insulin and octreotide. Glucose 202-209 fibrinogen beta chain Homo sapiens 16-26 9187410-6 1997 PAI-1, FVII and fibrinogen levels were significantly correlated with the degree of insulin resistance estimated by the steady state plasma glucose concentration (SSPG) during the continuous infusion of glucose, insulin and octreotide. Octreotide 223-233 fibrinogen beta chain Homo sapiens 16-26 9057641-13 1997 Our findings suggest that binding of NNKY5-5 to GPIb potentiates platelet aggregation by facilitating the interaction between fibrinogen and GPIIb/IIIa through a mechanism associated with p72syk activation and tyrosine phosphorylation of a 64-kD protein. Tyrosine 210-218 fibrinogen beta chain Homo sapiens 126-136 9126342-0 1997 Evidence for the involvement of phosphatidylinositol 4,5-bisphosphate 3-kinase in CD18-mediated adhesion of human neutrophils to fibrinogen. Phosphatidylinositols 32-52 fibrinogen beta chain Homo sapiens 129-139 9066019-0 1997 Ticlopidine may reduce functional fibrinogen levels by inhibition of MPC incorporation into fibrin. Ticlopidine 0-11 fibrinogen beta chain Homo sapiens 34-44 9087872-3 1997 With the heparin-induced-low-density lipoprotein-precipitation (HELP), low-density lipoprotein (LDL), fibrinogen, and lipoprotein(a) can be reduced about 55%, 50%, and 60%, respectively. Heparin 9-16 fibrinogen beta chain Homo sapiens 102-112 9030612-1 1997 Previous studies have shown that fibrinogen can associate with endothelial cells via an Arg-Gly-Asp (RGD) recognition specificity. Arginine 88-91 fibrinogen beta chain Homo sapiens 33-43 9030612-1 1997 Previous studies have shown that fibrinogen can associate with endothelial cells via an Arg-Gly-Asp (RGD) recognition specificity. Glycine 92-95 fibrinogen beta chain Homo sapiens 33-43 9030612-1 1997 Previous studies have shown that fibrinogen can associate with endothelial cells via an Arg-Gly-Asp (RGD) recognition specificity. Aspartic Acid 96-99 fibrinogen beta chain Homo sapiens 33-43 9030612-3 1997 Fibrinogen binding to suspended endothelial cells was selectively supported by Mn2+ and was suppressed by Ca2+. Manganese(2+) 79-83 fibrinogen beta chain Homo sapiens 0-10 9030612-7 1997 The binding of fibrinogen to alpha5beta1 on endothelial cells in the presence of Mn2+ was time-dependent, specific, saturable, and of high affinity (Kd = 65 nM). Manganese(2+) 81-85 fibrinogen beta chain Homo sapiens 15-25 9054738-6 1997 Subjects with hypobetalipoproteinemia (LDL cholesterol < 70 mg/dL) had the lowest levels of fibrinogen, plasminogen activator inhibitor-1 antigen, and tissue plasminogen activator antigen. Cholesterol 43-54 fibrinogen beta chain Homo sapiens 95-105 9028319-3 1997 The enhanced adhesion to fibrinogen or fibronectin was mediated by the Arg-Gly-Asp (RGD) recognition sequence of alpha IIb beta 3, as it was abolished by pretreatment of cells with saturating concentrations of RGDS peptide. arginyl-glycyl-aspartic acid 71-82 fibrinogen beta chain Homo sapiens 25-35 9203509-1 1997 With the addition of fibrinogen, fibrin clots form in serum-free culture medium recovered from phorbol ester-treated THP-1 cells. Phorbol Esters 95-108 fibrinogen beta chain Homo sapiens 21-31 9126503-12 1997 S-TSA level correlated significantly and positively with fibrinogen levels in Caucasian and Japanese men and women and with triglyceride levels in Caucasian and Japanese men and in Caucasian women but not in Japanese women. trichostatin A 2-5 fibrinogen beta chain Homo sapiens 57-67 9058482-7 1997 In the presence of fibrinogen, platelets from NR lacked phospholipase A2 activation, determined by arachidonic acid liberation in the presence of inhibitors to cyclooxygenase and lipoxygenase. Arachidonic Acid 99-115 fibrinogen beta chain Homo sapiens 19-29 9056289-0 1997 Competitive Protein Adsorption at Plasma Polymer Surfaces Competitive adsorption from a ternary mixture of human serum albumin (HSA), human IgG, and human fibrinogen (Fgn) at concentrations corresponding to blood plasma diluted 1/100 was investigated with the combination of Total Internal Reflection Fluorescence spectroscopy (TIRF) and ellipsometry. Polymers 41-48 fibrinogen beta chain Homo sapiens 155-165 9056289-0 1997 Competitive Protein Adsorption at Plasma Polymer Surfaces Competitive adsorption from a ternary mixture of human serum albumin (HSA), human IgG, and human fibrinogen (Fgn) at concentrations corresponding to blood plasma diluted 1/100 was investigated with the combination of Total Internal Reflection Fluorescence spectroscopy (TIRF) and ellipsometry. Polymers 41-48 fibrinogen beta chain Homo sapiens 167-170 9056289-5 1997 On PP-DACH and PP-AA, representing positively and negatively charged hydrophilic surfaces, respectively, Fgn completely dominated the adsorbed layer while HSA was almost absent and IgG was present only at a very low level. pp-dach 3-10 fibrinogen beta chain Homo sapiens 105-108 9056289-5 1997 On PP-DACH and PP-AA, representing positively and negatively charged hydrophilic surfaces, respectively, Fgn completely dominated the adsorbed layer while HSA was almost absent and IgG was present only at a very low level. polyterephthalic acid anhydride 15-20 fibrinogen beta chain Homo sapiens 105-108 9016719-4 1997 Fibrinogen is a 340 kDa glycoprotein composed of six polypeptide chains, (alphabetagamma)2, held together by 29 disulfide bonds. Disulfides 112-121 fibrinogen beta chain Homo sapiens 0-10 8994427-11 1997 CONCLUSIONS: The three main classes of antianginal medication have different and possible clinically relevant effects on platelet behavior in vivo, nitrates causing inhibition of aggregation (fibrinogen binding) and degranulation (P-selectin expression), calcium antagonists enhancing degranulation, and beta-blockers enhancing aggregation. Nitrates 148-156 fibrinogen beta chain Homo sapiens 192-202 8994427-6 1997 In addition, fibrinogen binding and P-selectin expression were measured in response to ex vivo stimulation with the agonists ADP and thrombin. Adenosine Diphosphate 125-128 fibrinogen beta chain Homo sapiens 13-23 9012636-5 1997 Adjustment for age, total cholesterol, HDL cholesterol, triglycerides, current smoking, and systolic pressure slightly reduced the association between fibrinogen and atherosclerosis. Cholesterol 26-37 fibrinogen beta chain Homo sapiens 151-161 8994427-8 1997 GTN inhibited platelet fibrinogen binding and expression of P-selectin at rest and in response to agonist stimulation, whereas amlodipine enhanced P-selectin expression and atenolol increased fibrinogen binding in response to agonists. Nitroglycerin 0-3 fibrinogen beta chain Homo sapiens 23-33 9012636-5 1997 Adjustment for age, total cholesterol, HDL cholesterol, triglycerides, current smoking, and systolic pressure slightly reduced the association between fibrinogen and atherosclerosis. Cholesterol 43-54 fibrinogen beta chain Homo sapiens 151-161 9012636-5 1997 Adjustment for age, total cholesterol, HDL cholesterol, triglycerides, current smoking, and systolic pressure slightly reduced the association between fibrinogen and atherosclerosis. Triglycerides 56-69 fibrinogen beta chain Homo sapiens 151-161 9034837-1 1997 BACKGROUND: Heparin-induced extracorporeal LDL/fibrinogen precipitation (HELP) eliminates selectively fibrinogen, LDL, cholesterol, triglycerides and LP(a) from blood plasma using extracorporeal circulation. Heparin 12-19 fibrinogen beta chain Homo sapiens 47-57 9117995-0 1997 Photo-oxidation of histidine as a probe for aminoterminal conformational changes during fibrinogen-fibrin conversion. Histidine 19-28 fibrinogen beta chain Homo sapiens 88-98 9117995-1 1997 Fibrinogen is known to become unclottable when irradiated with light in the presence of methylene blue, the loss of clottability being due to photo-oxidation of the histidine at position 16 of the B beta chain. Methylene Blue 88-102 fibrinogen beta chain Homo sapiens 0-10 9117995-1 1997 Fibrinogen is known to become unclottable when irradiated with light in the presence of methylene blue, the loss of clottability being due to photo-oxidation of the histidine at position 16 of the B beta chain. Histidine 165-174 fibrinogen beta chain Homo sapiens 0-10 9034837-1 1997 BACKGROUND: Heparin-induced extracorporeal LDL/fibrinogen precipitation (HELP) eliminates selectively fibrinogen, LDL, cholesterol, triglycerides and LP(a) from blood plasma using extracorporeal circulation. Heparin 12-19 fibrinogen beta chain Homo sapiens 102-112 9034837-1 1997 BACKGROUND: Heparin-induced extracorporeal LDL/fibrinogen precipitation (HELP) eliminates selectively fibrinogen, LDL, cholesterol, triglycerides and LP(a) from blood plasma using extracorporeal circulation. Cholesterol 119-130 fibrinogen beta chain Homo sapiens 47-57 9105974-1 1997 The interaction of plasma proteins such as albumin, gamma-globulin, and fibrinogen with the surface of graft copolymers DMAA-G-PTFE, DMAA-G-PETFE, and DMAA-G-PE obtained by radiation graft polymerization was studied. 17-N,N-diethylcarbamoyl-4-methyl-4-azaandrostane-3-one 120-124 fibrinogen beta chain Homo sapiens 72-82 9034837-1 1997 BACKGROUND: Heparin-induced extracorporeal LDL/fibrinogen precipitation (HELP) eliminates selectively fibrinogen, LDL, cholesterol, triglycerides and LP(a) from blood plasma using extracorporeal circulation. Triglycerides 132-145 fibrinogen beta chain Homo sapiens 47-57 9342652-4 1997 Minimum magnitudes in albumin and fibrinogen adsorption were observed on the polypropylene surface with a particular surface layer crystallinity (c. 55 wt%). Polypropylenes 77-90 fibrinogen beta chain Homo sapiens 34-44 9105974-1 1997 The interaction of plasma proteins such as albumin, gamma-globulin, and fibrinogen with the surface of graft copolymers DMAA-G-PTFE, DMAA-G-PETFE, and DMAA-G-PE obtained by radiation graft polymerization was studied. 17-N,N-diethylcarbamoyl-4-methyl-4-azaandrostane-3-one 133-137 fibrinogen beta chain Homo sapiens 72-82 9105974-1 1997 The interaction of plasma proteins such as albumin, gamma-globulin, and fibrinogen with the surface of graft copolymers DMAA-G-PTFE, DMAA-G-PETFE, and DMAA-G-PE obtained by radiation graft polymerization was studied. 17-N,N-diethylcarbamoyl-4-methyl-4-azaandrostane-3-one 133-137 fibrinogen beta chain Homo sapiens 72-82 9490335-2 1997 It was found that use of ozone-oxygen mixtures leads to hypocoagulatory changes (diminution of platelet aggregation, lowering of fibrinogen concentration, prolongation of activated partial thromboplastin time, enhanced fibrinolytic activity) which contribute to clinical response. Ozone 25-30 fibrinogen beta chain Homo sapiens 129-139 9490335-2 1997 It was found that use of ozone-oxygen mixtures leads to hypocoagulatory changes (diminution of platelet aggregation, lowering of fibrinogen concentration, prolongation of activated partial thromboplastin time, enhanced fibrinolytic activity) which contribute to clinical response. Oxygen 31-37 fibrinogen beta chain Homo sapiens 129-139 9364203-6 1997 PDGF, fibrinogen or 10% FCS significantly stimulated hASMC migration, however, omega-3 PUFA significantly inhibited PDGF-induced migration of hASMC. hasmc 53-58 fibrinogen beta chain Homo sapiens 6-16 9195550-12 1997 However, in the presence of fibrinogen, cycling of KL4 resulted in ultraheavy subtypes. sinapultide 51-54 fibrinogen beta chain Homo sapiens 28-38 9364203-6 1997 PDGF, fibrinogen or 10% FCS significantly stimulated hASMC migration, however, omega-3 PUFA significantly inhibited PDGF-induced migration of hASMC. hasmc 142-147 fibrinogen beta chain Homo sapiens 6-16 9071156-8 1997 SDS-polyacrylamide gel electrophoresis showed that HAT can cleave fibrinogen. sds-polyacrylamide 0-18 fibrinogen beta chain Homo sapiens 66-76 16793677-9 1997 Surprisingly arginyl-glycyl aspartyl serine (RGDS) inhibited the formation of both types of conjugate but this may be because it also inhibited both platelet and leukocyte activation as measured by CD62P and CD11b exposure and/or interferes with the binding of adhesion molecules other than fibrinogen. arginyl-glycyl-aspartyl-serine 13-43 fibrinogen beta chain Homo sapiens 291-301 20297942-0 1997 "ADP-induced binding of fibrinogen to activated platelets is rapid and parallels platelet microaggregation". Adenosine Diphosphate 1-4 fibrinogen beta chain Homo sapiens 24-34 9031453-0 1997 Modulation of plasma fibrinogen levels by ciprofibrate and gemfibrozil in primary hyperlipidaemia. ciprofibrate 42-54 fibrinogen beta chain Homo sapiens 21-31 9031453-0 1997 Modulation of plasma fibrinogen levels by ciprofibrate and gemfibrozil in primary hyperlipidaemia. Gemfibrozil 59-70 fibrinogen beta chain Homo sapiens 21-31 9031453-4 1997 We studied fibrinogen levels after 12 weeks of treatment with ciprofibrate (n = 48) and gemfibrozil (n = 51) in hypercholesterolenic patients. ciprofibrate 62-74 fibrinogen beta chain Homo sapiens 11-21 9205981-6 1997 The binding of fibrinogen to platelet Gp IIb/IIIa occurs via a specific amino acid sequence, arginine-glycine-aspartic acid. arginine-glycine 93-109 fibrinogen beta chain Homo sapiens 15-25 9205981-6 1997 The binding of fibrinogen to platelet Gp IIb/IIIa occurs via a specific amino acid sequence, arginine-glycine-aspartic acid. Aspartic Acid 110-123 fibrinogen beta chain Homo sapiens 15-25 9125320-0 1996 Comment on: effect of pravastatin sodium and simvastatin on plasma fibrinogen level and blood rheology in type II hyperlipoproteinemia. Pravastatin 22-40 fibrinogen beta chain Homo sapiens 67-77 9125320-0 1996 Comment on: effect of pravastatin sodium and simvastatin on plasma fibrinogen level and blood rheology in type II hyperlipoproteinemia. Simvastatin 45-56 fibrinogen beta chain Homo sapiens 67-77 8956627-2 1996 Fibrinogen concentrations controlling for age, body mass index, ethanol intake, serum total cholesterol, diabetes mellitus, and menopausal status were 8.6 (95% confidence interval 1.6-15.6) mg/dl higher in women exposed passively to smoking outside the home (n = 435) and 11.2 (95% confidence interval 3.0-19.3) mg/dl higher in women exposed both in and outside the home (n = 272) than in women unexposed in either location (n = 524). Ethanol 64-71 fibrinogen beta chain Homo sapiens 0-10 8956627-2 1996 Fibrinogen concentrations controlling for age, body mass index, ethanol intake, serum total cholesterol, diabetes mellitus, and menopausal status were 8.6 (95% confidence interval 1.6-15.6) mg/dl higher in women exposed passively to smoking outside the home (n = 435) and 11.2 (95% confidence interval 3.0-19.3) mg/dl higher in women exposed both in and outside the home (n = 272) than in women unexposed in either location (n = 524). Cholesterol 92-103 fibrinogen beta chain Homo sapiens 0-10 9007155-8 1996 A number of statistically significant but low correlations (-0.32 to 0.24) were found between plasma fibrinogen and high density lipoprotein cholesterol (HDL-C) as a percentage of total cholesterol, triglycerides, blood glucose, uric acid, blood pressure, Quetelet index and sports activity. density lipoprotein cholesterol 121-152 fibrinogen beta chain Homo sapiens 101-111 9022036-3 1997 We demonstrate that vitronectin and fibrinogen, but not laminin or collagen, are also able to both facilitate degranulation in the presence of substimulatory anti-CD3 and stimulate tyrosine phosphorylation of these 115-125-kDa proteins, with a 115-kDa protein being the most prominently phosphorylated. Tyrosine 181-189 fibrinogen beta chain Homo sapiens 36-46 25132726-0 1996 Chemical pattern on silica surface prepared by UV irradiation of 3-mercaptopropyltriethoxy silane layer: surface characterization and fibrinogen adsorption. Silicon Dioxide 20-26 fibrinogen beta chain Homo sapiens 134-144 25132726-0 1996 Chemical pattern on silica surface prepared by UV irradiation of 3-mercaptopropyltriethoxy silane layer: surface characterization and fibrinogen adsorption. 3-mercaptopropyltriethoxy silane 65-97 fibrinogen beta chain Homo sapiens 134-144 25132726-7 1996 The adsorption of fluorescein-labeled fibrinogen (FITC-Fgn) from dilute buffer solution also produced visual information on the pattern. Fluorescein 18-29 fibrinogen beta chain Homo sapiens 38-48 25132726-7 1996 The adsorption of fluorescein-labeled fibrinogen (FITC-Fgn) from dilute buffer solution also produced visual information on the pattern. Fluorescein-5-isothiocyanate 50-54 fibrinogen beta chain Homo sapiens 38-48 9141800-12 1996 Steroid therapy significantly increased the levels of proteins C, protein S. AT-III and fibrinogen as compared to controls. Steroids 0-7 fibrinogen beta chain Homo sapiens 88-98 9007155-8 1996 A number of statistically significant but low correlations (-0.32 to 0.24) were found between plasma fibrinogen and high density lipoprotein cholesterol (HDL-C) as a percentage of total cholesterol, triglycerides, blood glucose, uric acid, blood pressure, Quetelet index and sports activity. Cholesterol 141-152 fibrinogen beta chain Homo sapiens 101-111 8954635-0 1996 Tenacious Binding of Fibrinogen and Albumin to Pyrolite Carbon and Biomer Adsorption of bovine fibrinogen from dilute plasma and human serum albumin (HSA) from buffered HSA solution to low-temperature isotropic (LTI) pyrolytic carbon (Pyrolite) and polyetherurethane urea (Biomer) was measured. Carbon 56-62 fibrinogen beta chain Homo sapiens 21-31 9007155-8 1996 A number of statistically significant but low correlations (-0.32 to 0.24) were found between plasma fibrinogen and high density lipoprotein cholesterol (HDL-C) as a percentage of total cholesterol, triglycerides, blood glucose, uric acid, blood pressure, Quetelet index and sports activity. Glucose 220-227 fibrinogen beta chain Homo sapiens 101-111 8954635-0 1996 Tenacious Binding of Fibrinogen and Albumin to Pyrolite Carbon and Biomer Adsorption of bovine fibrinogen from dilute plasma and human serum albumin (HSA) from buffered HSA solution to low-temperature isotropic (LTI) pyrolytic carbon (Pyrolite) and polyetherurethane urea (Biomer) was measured. Carbon 227-233 fibrinogen beta chain Homo sapiens 95-105 9007155-8 1996 A number of statistically significant but low correlations (-0.32 to 0.24) were found between plasma fibrinogen and high density lipoprotein cholesterol (HDL-C) as a percentage of total cholesterol, triglycerides, blood glucose, uric acid, blood pressure, Quetelet index and sports activity. Uric Acid 229-238 fibrinogen beta chain Homo sapiens 101-111 8954635-0 1996 Tenacious Binding of Fibrinogen and Albumin to Pyrolite Carbon and Biomer Adsorption of bovine fibrinogen from dilute plasma and human serum albumin (HSA) from buffered HSA solution to low-temperature isotropic (LTI) pyrolytic carbon (Pyrolite) and polyetherurethane urea (Biomer) was measured. Carbon 235-243 fibrinogen beta chain Homo sapiens 95-105 8972015-5 1996 We conclude that decreased erythrocyte sialic acid content may intensify the effect of fibrinogen on aggregation and disaggregation of erythrocytes and participate in the development of atherothrombotic complications. N-Acetylneuraminic Acid 39-50 fibrinogen beta chain Homo sapiens 87-97 8954635-0 1996 Tenacious Binding of Fibrinogen and Albumin to Pyrolite Carbon and Biomer Adsorption of bovine fibrinogen from dilute plasma and human serum albumin (HSA) from buffered HSA solution to low-temperature isotropic (LTI) pyrolytic carbon (Pyrolite) and polyetherurethane urea (Biomer) was measured. polyetherurethane urea 249-271 fibrinogen beta chain Homo sapiens 95-105 8954635-3 1996 The amount of fibrinogen eluted from both substrates by SDS was less when the protein was adsorbed from more dilute plasma or eluted after 4 days postadsorptive residence time. Sodium Dodecyl Sulfate 56-59 fibrinogen beta chain Homo sapiens 14-24 8954635-4 1996 Under all conditions, fibrinogen retention by Pyrolite was greater than that by Biomer. Carbon 46-54 fibrinogen beta chain Homo sapiens 22-32 8954635-6 1996 Antibody binding (normalized to the amount of fibrinogen adsorbed) to plasma preadsorbed Pyrolite was much less than that to preadsorbed Biomer. Carbon 89-97 fibrinogen beta chain Homo sapiens 46-56 8975881-3 1996 We and others reported that when PMN are plated onto fibrinogen and stimulated with cytokines or with the chemotactic peptide N-formyl-methionyl-leucyl-phenylalanine (fMLP) they respond by releasing hydrogen peroxide (H202) and the specific granule component lactoferrin. Hydrogen Peroxide 199-216 fibrinogen beta chain Homo sapiens 53-63 8975881-3 1996 We and others reported that when PMN are plated onto fibrinogen and stimulated with cytokines or with the chemotactic peptide N-formyl-methionyl-leucyl-phenylalanine (fMLP) they respond by releasing hydrogen peroxide (H202) and the specific granule component lactoferrin. h202 218-222 fibrinogen beta chain Homo sapiens 53-63 8975881-6 1996 We hypothesized that TGF-beta1 would activate PMN to release H202 when they were adherent to fibrinogen, a response mediated by beta2++integrin receptors. h202 61-65 fibrinogen beta chain Homo sapiens 93-103 8975881-7 1996 In this study, we determined whether TGF-beta1 stimulated H202 and lactoferrin release by PMN adherent to fibrinogen. h202 58-62 fibrinogen beta chain Homo sapiens 106-116 8962506-1 1996 A domain binding model was developed for explaining the multiple peak chromatograms obtained in the high-performance liquid chromatography of pure fibrinogen on a DEAE polymethacrylate column using different gradients of ammonium chloride. deae polymethacrylate 163-184 fibrinogen beta chain Homo sapiens 147-157 8972033-3 1996 The addition of polystyrene beads coated with von Willebrand factor (vWF) or fibrinogen (Fg) to platelet suspensions caused prompt aggregation of beads and platelets, which was detected as an increase in light transmission. Polystyrenes 16-27 fibrinogen beta chain Homo sapiens 77-87 8954635-0 1996 Tenacious Binding of Fibrinogen and Albumin to Pyrolite Carbon and Biomer Adsorption of bovine fibrinogen from dilute plasma and human serum albumin (HSA) from buffered HSA solution to low-temperature isotropic (LTI) pyrolytic carbon (Pyrolite) and polyetherurethane urea (Biomer) was measured. Carbon 47-55 fibrinogen beta chain Homo sapiens 21-31 9026757-3 1996 During a 3 week long treatment in the Cardiac Rehabilitation Department the effect of low cholesterol, high unsaturated fatty acid content diet on the lipid, apolipoprotein and fibrinogen levels of male patients suffering from coronary heart disease with cholesterol level higher than 5.2 mmol/l was studied. Cholesterol 90-101 fibrinogen beta chain Homo sapiens 177-187 8962506-1 1996 A domain binding model was developed for explaining the multiple peak chromatograms obtained in the high-performance liquid chromatography of pure fibrinogen on a DEAE polymethacrylate column using different gradients of ammonium chloride. Ammonium Chloride 221-238 fibrinogen beta chain Homo sapiens 147-157 8904681-1 1996 The effect cilazapril (CLZ) treatment on serum lipids and fibrinogen was studied in 114 hypertensive patients for 18 weeks. Cilazapril 23-26 fibrinogen beta chain Homo sapiens 58-68 8922606-13 1996 The ellipsometric results show that the adsorption of HSA and Fg at HMS surfaces containing preadsorbed amphiphilic polymer was significantly reduced as compared to the bare HMS surface. Polymers 116-123 fibrinogen beta chain Homo sapiens 62-64 8922606-15 1996 Both polymers gave more than a 20-fold reduction of the Fg adsorption and a 10-fold reduction of the HSA adsorption. Polymers 5-13 fibrinogen beta chain Homo sapiens 56-58 8993943-10 1996 Drug combination and ciprofibrate significantly reduced plasma fibrinogen (-24 and -25%, respectively; P < 0.001) and triglycerides (-51 and -49%, respectively; P < 0.001). ciprofibrate 21-33 fibrinogen beta chain Homo sapiens 63-73 8993943-15 1996 CONCLUSION: Combined treatment with simvastatin and ciprofibrate effectively reduced plasma fibrinogen, triglycerides, total and LDL cholesterol and increased LDL particle size in patients with FCHL and CAD. Simvastatin 36-47 fibrinogen beta chain Homo sapiens 92-102 8993943-15 1996 CONCLUSION: Combined treatment with simvastatin and ciprofibrate effectively reduced plasma fibrinogen, triglycerides, total and LDL cholesterol and increased LDL particle size in patients with FCHL and CAD. ciprofibrate 52-64 fibrinogen beta chain Homo sapiens 92-102 8908392-6 1996 In a logistic regression model, including age, BMI, cholesterol, sex, smoking, triglycerides, and plasminogen activator inhibitor antigen as covariates, genotype and fibrinogen levels were significantly associated with CAD. Cholesterol 52-63 fibrinogen beta chain Homo sapiens 166-176 8908392-6 1996 In a logistic regression model, including age, BMI, cholesterol, sex, smoking, triglycerides, and plasminogen activator inhibitor antigen as covariates, genotype and fibrinogen levels were significantly associated with CAD. Triglycerides 79-92 fibrinogen beta chain Homo sapiens 166-176 8824251-0 1996 Binding of fibrin monomer and heparin to thrombin in a ternary complex alters the environment of the thrombin catalytic site, reduces affinity for hirudin, and inhibits cleavage of fibrinogen. Heparin 30-37 fibrinogen beta chain Homo sapiens 181-191 8824251-6 1996 These results support a ternary complex model in which heparin binding through exosite II of thrombin facilitates fibrin monomer binding via exosite I, with accompanying changes in thrombin catalytic specificity resulting from perturbations in the active site and reduced accessibility of exosite I to hirudin and fibrinogen. Heparin 55-62 fibrinogen beta chain Homo sapiens 314-324 8849150-15 1996 In a multiple regression analysis, hemoglobin A1c value (b = 0.06; P < 0.001) and albumin excretion rate (b = 0.09; P = 0.005) were associated with fibrinogen level independent of other cardiovascular risk factors (sex, age, hypertensive status, total cholesterol level, smoking habit, and body mass index). Cholesterol 255-266 fibrinogen beta chain Homo sapiens 151-161 8798716-4 1996 Fibrinogen chain assembly required microsomal membranes and oxidized glutathione. Glutathione 69-80 fibrinogen beta chain Homo sapiens 0-10 8839852-3 1996 However, we unexpectedly found that high concentrations of amiloride dose-dependently inhibited 125I-fibrinogen binding to the chymotrypsin-treated platelets, as well as the platelet aggregation (IC50 [50% inhibitory concentration] for fibrinogen binding, 530 mumol/L). Amiloride 59-68 fibrinogen beta chain Homo sapiens 101-111 8839852-3 1996 However, we unexpectedly found that high concentrations of amiloride dose-dependently inhibited 125I-fibrinogen binding to the chymotrypsin-treated platelets, as well as the platelet aggregation (IC50 [50% inhibitory concentration] for fibrinogen binding, 530 mumol/L). Amiloride 59-68 fibrinogen beta chain Homo sapiens 236-246 8839852-6 1996 Lowering Na+ gradient by replacing extracellular Na+ with tetramethylammonium (TMA) increased the number of activated alpha IIb beta 3 by twofold, as assessed by fibrinogen-binding assay. tetramethylammonium 58-77 fibrinogen beta chain Homo sapiens 162-172 8839852-11 1996 3",4"-Dichlorobenzamil (DCB) and bepridil, relatively specific inhibitors of Na+/Ca2+ exchanger, also inhibited the chymotrypsin-induced alpha IIb beta 3 activation, and the IC50 values of these inhibitors for fibrinogen binding were 25 mumol/L and 52 mumol/L, respectively. 3',4'-dichlorobenzamil 0-22 fibrinogen beta chain Homo sapiens 210-220 8839852-11 1996 3",4"-Dichlorobenzamil (DCB) and bepridil, relatively specific inhibitors of Na+/Ca2+ exchanger, also inhibited the chymotrypsin-induced alpha IIb beta 3 activation, and the IC50 values of these inhibitors for fibrinogen binding were 25 mumol/L and 52 mumol/L, respectively. 3',4'-dichlorobenzamil 24-27 fibrinogen beta chain Homo sapiens 210-220 8839852-11 1996 3",4"-Dichlorobenzamil (DCB) and bepridil, relatively specific inhibitors of Na+/Ca2+ exchanger, also inhibited the chymotrypsin-induced alpha IIb beta 3 activation, and the IC50 values of these inhibitors for fibrinogen binding were 25 mumol/L and 52 mumol/L, respectively. Bepridil 33-41 fibrinogen beta chain Homo sapiens 210-220 8941686-2 1996 Ancrod and Iloprost have been employed but are not readily available and carry the risks of systemic side effects (depletion of fibrinogen, hypotension). Iloprost 11-19 fibrinogen beta chain Homo sapiens 128-138 8899146-0 1996 Plasma fibrinogen and its relationship to plasma sialic acid in non-insulin-dependent diabetes mellitus. N-Acetylneuraminic Acid 49-60 fibrinogen beta chain Homo sapiens 7-17 8899146-2 1996 We postulated that plasma SA may be related to plasma fibrinogen, another reputed cardiovascular risk factor. N-Acetylneuraminic Acid 26-28 fibrinogen beta chain Homo sapiens 54-64 8899146-6 1996 There was a strong univariate correlation between plasma fibrinogen and plasma SA in both NIDDM patients (r = 0.80, P < 0.001) and control subjects (r = 0.54, P < 0.01). N-Acetylneuraminic Acid 79-81 fibrinogen beta chain Homo sapiens 57-67 8880021-3 1996 Acetylsalicylic acid, however, also acetylates fibrinogen. Aspirin 0-20 fibrinogen beta chain Homo sapiens 47-57 8880021-11 1996 In conclusion, the protective effect of acetylsalicylic acid may be ascribed to its effect not only on platelets but also on fibrinogen. Aspirin 40-60 fibrinogen beta chain Homo sapiens 125-135 9174920-4 1996 The bound fibrinogen showed weak clotting activity when eluted with 20 mM acetate buffer, pH 4. Acetates 74-81 fibrinogen beta chain Homo sapiens 10-20 8883005-1 1996 The relation of daily energy expenditure (EE) and maximal oxygen uptake (VO2max) to plasma fibrinogen with reference to DNA polymorphism was analyzed in a random sample of men (N = 189), age 50-60. Oxygen 58-64 fibrinogen beta chain Homo sapiens 91-101 8913077-0 1996 Effects of omega 3-PUFA on plasma fibrinogen levels in hypertriglyceridemic hemodialysis patients. omega 3-pufa 11-23 fibrinogen beta chain Homo sapiens 34-44 8883274-0 1996 Normal binding of calcium to five fibrinogen variants with mutations in the carboxy terminal part of the gamma-chain. Calcium 18-25 fibrinogen beta chain Homo sapiens 34-44 8883274-2 1996 Each of the two carboxy terminal domains of normal fibrinogen contains one high-affinity calcium binding site that seems to be situated close to the polymerization site in the gamma-chain. Calcium 89-96 fibrinogen beta chain Homo sapiens 51-61 8883274-5 1996 We investigated binding of calcium to fibrinogen and the effect of calcium on the clotting properties of five heterozygous fibrinogen variants showing normal thrombin-induced fibrinopeptide release but abnormal polymerization of fibrin monomers. Calcium 27-34 fibrinogen beta chain Homo sapiens 38-48 8883274-7 1996 The shortest thrombin clotting time and the earliest onset of turbidity increase were observed in fibrinogen gamma 358 Ser-->Cys; both parameters were little affected by calcium concentration. Serine 119-122 fibrinogen beta chain Homo sapiens 98-108 8883274-7 1996 The shortest thrombin clotting time and the earliest onset of turbidity increase were observed in fibrinogen gamma 358 Ser-->Cys; both parameters were little affected by calcium concentration. Cysteine 128-131 fibrinogen beta chain Homo sapiens 98-108 8883274-9 1996 In contrast, the abnormal fibrin polymerization of fibrinogen gamma 330 Asp-->Val was barely improved at increasing calcium concentrations. Aspartic Acid 72-75 fibrinogen beta chain Homo sapiens 51-61 8883274-9 1996 In contrast, the abnormal fibrin polymerization of fibrinogen gamma 330 Asp-->Val was barely improved at increasing calcium concentrations. Valine 81-84 fibrinogen beta chain Homo sapiens 51-61 8883274-9 1996 In contrast, the abnormal fibrin polymerization of fibrinogen gamma 330 Asp-->Val was barely improved at increasing calcium concentrations. Calcium 119-126 fibrinogen beta chain Homo sapiens 51-61 8883279-2 1996 Smoking was positively associated with fibrinogen, also after adjustment for other lifestyle factors, age, use of anticoagulants and aspirin like drugs, body mass index, and history of myocardial infarction. Aspirin 133-140 fibrinogen beta chain Homo sapiens 39-49 8765234-2 1996 Here, NMR and transferred NOE studies have been done with the fibrinogen/fibronectin-derived hexapeptide GRGDSP in the presence of sodium dodecyl sulfate (SDS) and purified platelet glycoprotein integrin receptor GPIIb/IIIa. Sodium Dodecyl Sulfate 131-153 fibrinogen beta chain Homo sapiens 62-72 8765234-2 1996 Here, NMR and transferred NOE studies have been done with the fibrinogen/fibronectin-derived hexapeptide GRGDSP in the presence of sodium dodecyl sulfate (SDS) and purified platelet glycoprotein integrin receptor GPIIb/IIIa. Sodium Dodecyl Sulfate 155-158 fibrinogen beta chain Homo sapiens 62-72 8910396-5 1996 The incorporation of preformed alphagamma and betagamma complexes into secreted fibrinogen did not require concurrent protein synthesis, as shown by experiments employing cycloheximide. Cycloheximide 171-184 fibrinogen beta chain Homo sapiens 80-90 8910397-2 1996 Fibrinogen is a plasma protein consisting of six polypeptide chains which are linked by disulfide bonds. Disulfides 88-97 fibrinogen beta chain Homo sapiens 0-10 8970768-7 1996 XV459 inhibited [125I]-fibrinogen binding to activated human platelets with an IC50 of 0.011 +/- 0.003 mumol/l. XV 459 0-5 fibrinogen beta chain Homo sapiens 23-33 8970768-8 1996 XV459 demonstrated a high degree of selectivity in specifically inhibiting fibrinogen binding to the platelet integrin, GPIIb/IIIa (IC50 = 0.00025 +/- 0.00005 mumol/l) compared with inhibiting other integrins (alpha v beta 3, IC50 > 10 mumol/l; or alpha v beta 5, alpha 5 beta 1, or alpha 4 beta 1, for which the IC50 exceeded 100 mumol/l). XV 459 0-5 fibrinogen beta chain Homo sapiens 75-85 8979111-7 1996 It is important to continue research on the effects of palm oil based diet on plasma fibrinogen, factor VII. Palm Oil 55-63 fibrinogen beta chain Homo sapiens 85-95 8843189-11 1996 However, with fenofibrate therapy, in addition to comparable lipoprotein changes seen with fish oil, fibrinogen levels and plasma and blood viscosity decreased in patients with FDL. Fenofibrate 14-25 fibrinogen beta chain Homo sapiens 101-111 8905024-9 1996 Significant reductions of plasma fibrinogen by 14% and AT III by 8% were seen in women who received tamoxifen. Tamoxifen 100-109 fibrinogen beta chain Homo sapiens 33-43 8864019-0 1996 Reduction of plasma fibrinogen, immunoglobulin G, and immunoglobulin M concentrations by immunoadsorption therapy with tryptophan and phenylalanine adsorbents. Tryptophan 119-129 fibrinogen beta chain Homo sapiens 20-30 8904681-4 1996 We conclude that CLZ has a slight beneficial effect on the lipid profile and a significantly beneficial effect on fibrinogen, but its combination with a diuretic reverses this beneficial effect. Cilazapril 17-20 fibrinogen beta chain Homo sapiens 114-124 8704247-2 1996 Prolongation of the coagulation screening tests, prothrombin time, activated partial prothrombin time, and thrombin clotting time, in fetuses throughout intrauterine life was explained by low levels of vitamin K-dependent factors (II, VII, IX, and X), contact factors (XI, XII, prekallikrein, and high-molecular-weight kininogen), factor V, factor VIII, and fibrinogen. Vitamin K 202-211 fibrinogen beta chain Homo sapiens 358-368 8987550-0 1996 Evidence for the interaction between (-)-epigallocatechin gallate and human plasma proteins fibronectin, fibrinogen, and histidine-rich glycoprotein. epigallocatechin gallate 37-65 fibrinogen beta chain Homo sapiens 105-115 8987550-6 1996 Affinity chromatography of the individual proteins indicated that fibrinogen and HRG had direct affinity for EGCg. epigallocatechin gallate 109-113 fibrinogen beta chain Homo sapiens 66-76 8769353-3 1996 Subjects of both sexes with hypercholesterolemia (> 6.2 mmol/L) also had significant elevations of diastolic blood pressure, plasma glucose, triglycerides, fibrinogen, and factor VIIc and reduced PT and APTT compared with subjects with lower cholesterol. Cholesterol 33-44 fibrinogen beta chain Homo sapiens 159-169 9174920-3 1996 Fibrinogen from plasma bound to an NH2-GPRP-POROS column under 50 mM phosphate buffer, 0.15 M NaCl, pH 7 at 15 ml/min flow rate. Phosphates 69-78 fibrinogen beta chain Homo sapiens 0-10 9174920-3 1996 Fibrinogen from plasma bound to an NH2-GPRP-POROS column under 50 mM phosphate buffer, 0.15 M NaCl, pH 7 at 15 ml/min flow rate. Sodium Chloride 94-98 fibrinogen beta chain Homo sapiens 0-10 8712111-1 1996 Fibrinogen has emerged as a risk factor for coronary artery disease in men that equals cholesterol in importance. Cholesterol 87-98 fibrinogen beta chain Homo sapiens 0-10 8865524-0 1996 Modulation of plasma fibrinogen levels by ticlopidine in healthy volunteers and patients with stable angina pectoris. Ticlopidine 42-53 fibrinogen beta chain Homo sapiens 21-31 8865524-2 1996 Ticlopidine is a drug that inhibits the ADP-induced aggregation of blood platelets and it also has been described that ticlopidine can decrease the plasma fibrinogen level in patients with vascular diseases. Ticlopidine 0-11 fibrinogen beta chain Homo sapiens 155-165 8865524-2 1996 Ticlopidine is a drug that inhibits the ADP-induced aggregation of blood platelets and it also has been described that ticlopidine can decrease the plasma fibrinogen level in patients with vascular diseases. Ticlopidine 119-130 fibrinogen beta chain Homo sapiens 155-165 8865524-4 1996 The fibrinogen lowering effect of ticlopidine was studied in 26 healthy volunteers, selected on genotype of the Bcl] polymorphism of the fibrinogen beta-gene, and in 26 patients with stable angina pectoris in a double blind, randomized cross-over study. Ticlopidine 34-45 fibrinogen beta chain Homo sapiens 4-14 8865524-7 1996 In the healthy volunteers the functional fibrinogen levels had decreased by 0.20 g/l (9%, p = 0.005 using the paired Student l-test) after 4 weeks of 250 mg bid ticlopidine administration, whereas fibrinogen antigen, CRP and TDP levels were not significantly changed. Ticlopidine 161-172 fibrinogen beta chain Homo sapiens 41-51 8865524-9 1996 After four weeks 250 mg bid ticlopidine administration the functional fibrinogen levels had decreased by 0.38 g/l (11%, p < 0.005), whereas the fibrinogen antigen, CRP and TDP levels were not significantly changed. Ticlopidine 28-39 fibrinogen beta chain Homo sapiens 70-80 8865524-11 1996 Neither in the volunteers nor in the patients was the effect of ticlopidine on the fibrinogen levels associated with the fibrinogen beta-gene polymorphisms. Ticlopidine 64-75 fibrinogen beta chain Homo sapiens 83-93 8865524-11 1996 Neither in the volunteers nor in the patients was the effect of ticlopidine on the fibrinogen levels associated with the fibrinogen beta-gene polymorphisms. Ticlopidine 64-75 fibrinogen beta chain Homo sapiens 121-131 8865524-12 1996 Therefore, the fibrinogen lowering effect of ticlopidine is likely to be a modulation of the functionality of the molecule and unlikely to be modulated by the acute phase reaction, TDP-levels or the fibrinogen beta-gene polymorphisms. Ticlopidine 45-56 fibrinogen beta chain Homo sapiens 15-25 8865527-5 1996 The cleavage of fibrinogen and fibrin by PMN elastase, independent of plasmin, was indicated by the presence of the fragments in immunoprecipitated plasma from the patient corresponding to elastase-induced FDP D and DD fragments and the absence of fragments corresponding to plasmin-induced FDP D and DD fragments on SDS-PAGE. Sodium Dodecyl Sulfate 317-320 fibrinogen beta chain Homo sapiens 16-26 8831919-9 1996 Ciprofibrate therapy significantly reduced (-8.33%) and gemfibrozil therapy significantly increased (+6.97%) plasma fibrinogen levels (P < 0.001 compared with baseline in each case). Gemfibrozil 56-67 fibrinogen beta chain Homo sapiens 116-126 8831919-13 1996 Furthermore, ciprofibrate reduces fibrinogen levels and benefits from a once daily regimen. ciprofibrate 13-25 fibrinogen beta chain Homo sapiens 34-44 8666148-7 1996 The conditioned medium from monocytes treated with 33 mmol/l glucose increased beta-fibrinogen mRNA levels. Glucose 61-68 fibrinogen beta chain Homo sapiens 84-94 9631012-5 1996 Reducing sodium dodecyl sulfate polyacrylamide gel electrophoresis of milk from the highest producing founder animal demonstrated the presence of human fibrinogen subunits at concentrations of 2000 micrograms/ml. Sodium Dodecyl Sulfate 9-31 fibrinogen beta chain Homo sapiens 152-162 8756701-4 1996 When fibrinogen is purified from plasma, the factor XIII zymogen (A2B2) copurifies with it and is found only in the peak 2 fibrinogen when this fraction is separated from peak 1 fibrinogen by ion-exchange chromatography on DEAE-cellulose. DEAE-Cellulose 223-237 fibrinogen beta chain Homo sapiens 5-15 8839996-8 1996 In the LDL-apheresis device the main results were: (a) fibrinogen was trapped in the dextran sulphate cellulose column in the early phases; (b) activation of coagulation was recognisable in the plasma separator during the procedure and progressively increased with duration of LDL-apheresis; (c) thrombin-antithrombin complexes, formed in the plasma separator, were retained by the dextran sulphate cellulose column. Dextran Sulfate 85-101 fibrinogen beta chain Homo sapiens 55-65 8839996-8 1996 In the LDL-apheresis device the main results were: (a) fibrinogen was trapped in the dextran sulphate cellulose column in the early phases; (b) activation of coagulation was recognisable in the plasma separator during the procedure and progressively increased with duration of LDL-apheresis; (c) thrombin-antithrombin complexes, formed in the plasma separator, were retained by the dextran sulphate cellulose column. Dextran Sulfate 382-398 fibrinogen beta chain Homo sapiens 55-65 8839996-8 1996 In the LDL-apheresis device the main results were: (a) fibrinogen was trapped in the dextran sulphate cellulose column in the early phases; (b) activation of coagulation was recognisable in the plasma separator during the procedure and progressively increased with duration of LDL-apheresis; (c) thrombin-antithrombin complexes, formed in the plasma separator, were retained by the dextran sulphate cellulose column. Cellulose 102-111 fibrinogen beta chain Homo sapiens 55-65 9631012-5 1996 Reducing sodium dodecyl sulfate polyacrylamide gel electrophoresis of milk from the highest producing founder animal demonstrated the presence of human fibrinogen subunits at concentrations of 2000 micrograms/ml. polyacrylamide 32-46 fibrinogen beta chain Homo sapiens 152-162 8682642-11 1996 When fibrinogen and low density lipoprotein (LDL) concentration were considered together, there was a graded and dramatic eightfold increase in 8 year risk from 17 per 1,000 of population among men with both fibrinogen and LDL cholesterol in the lower tertiles to 130 per 1,000 in men with both of these parameters in the upper tertile. Cholesterol 227-238 fibrinogen beta chain Homo sapiens 5-15 8647947-7 1996 Endothelial cell adhesion and migration on fibrinogen were inhibited by both beta-d xyloside and after cleavage of chondroitin sulfate from the core protein by chondroitinase ABC. xylosides 77-92 fibrinogen beta chain Homo sapiens 43-53 8647947-7 1996 Endothelial cell adhesion and migration on fibrinogen were inhibited by both beta-d xyloside and after cleavage of chondroitin sulfate from the core protein by chondroitinase ABC. Chondroitin Sulfates 115-134 fibrinogen beta chain Homo sapiens 43-53 8863104-1 1996 BACKGROUND: The magnitude of the cardiovascular risk associated with plasma fibrinogen concentration is influenced separately by cigarette smoking and by low-density lipoprotein (LDL) cholesterol levels. Cholesterol 184-195 fibrinogen beta chain Homo sapiens 76-86 8863104-8 1996 For example, in current smokers in the bottom tertile of LDL cholesterol level, the odds of disease were 6.1 (95% confidence interval 2.2-17.0; P < or = 0.001) in the top tertile, 2.9 (95% confidence interval 1.0-8.6; P < or = 0.05) in the middle tertile and 1.6 (95% confidence interval 0.5-4.8; P > 0.05) in the bottom tertile of plasma fibrinogen level. Cholesterol 61-72 fibrinogen beta chain Homo sapiens 348-358 8863104-10 1996 CONCLUSION: The incorporation of plasma fibrinogen level permitted more precise delineation of the odds of disease within categories of smoking and LDL cholesterol concentration. Cholesterol 152-163 fibrinogen beta chain Homo sapiens 40-50 8752703-0 1996 [A study on the plasma fibrinogen decrease induced by danazol]. Danazol 54-61 fibrinogen beta chain Homo sapiens 23-33 9594175-6 1996 The early administration of heparin and aprotinin after the supplement of fibrinogen has shown a great potential benifit to stop the cascade of hypercoagulation and hyperplasminogenemia by enhancing the level of AT-III and fibrinogen in plasma. Heparin 28-35 fibrinogen beta chain Homo sapiens 74-84 8805975-8 1996 Moreover, evidence is presented that substantial amounts of albumin and fibrinogen, adsorbed from 1:1000 diluted plasma to glass and polyethylene, are displaced from the surfaces of these materials by proteins from 1:1 diluted plasma different from HMWK and HDL. Polyethylene 133-145 fibrinogen beta chain Homo sapiens 72-82 9594175-6 1996 The early administration of heparin and aprotinin after the supplement of fibrinogen has shown a great potential benifit to stop the cascade of hypercoagulation and hyperplasminogenemia by enhancing the level of AT-III and fibrinogen in plasma. Heparin 28-35 fibrinogen beta chain Homo sapiens 223-233 8647881-14 1996 Taken together, these results indicate that in addition to disulfide bonds, noncovalent interactions of other amino-terminal amino acid residues in the three fibrinogen chains also participate in dimer formation. Disulfides 59-68 fibrinogen beta chain Homo sapiens 158-168 8733958-0 1996 Platelet deposition and fibrinogen binding on surfaces coated with heparin or friction-reducing polymers. Heparin 67-74 fibrinogen beta chain Homo sapiens 24-34 8636415-4 1996 Fibrinogen Dusart, whose structural abnormality is in the COOH-terminal "alphaC" region of its Aalpha chain (Aalpha R554C-albumin), is associated with thrombophilia ("Dusart Syndrome"), and is characterized functionally by defective fibrin polymerization and clot structure, and reduced plasminogen binding and tPA-induced fibrinolysis. Tetradecanoylphorbol Acetate 311-314 fibrinogen beta chain Homo sapiens 0-10 8639542-1 1996 A peptide band of approximately 105 kDa migrating near the gamma dimer position of disulfide bond reduced human plasma fibrinogen prepared from fresh single donor or outdated plasma was identified by SDS-PAGE. Disulfides 83-92 fibrinogen beta chain Homo sapiens 119-129 8639542-1 1996 A peptide band of approximately 105 kDa migrating near the gamma dimer position of disulfide bond reduced human plasma fibrinogen prepared from fresh single donor or outdated plasma was identified by SDS-PAGE. Sodium Dodecyl Sulfate 200-203 fibrinogen beta chain Homo sapiens 119-129 8639542-4 1996 A alpha.gamma heterodimers were identified as a component of monomeric fibrinogen by two-dimensional SDS-PAGE and by SDS-PAGE analysis of the monomer fraction isolated by gel sieving chromatography, thus indicating that A alpha.gamma heterodimers arise by intramolecular A alpha/gamma chain cross-linking. Sodium Dodecyl Sulfate 101-104 fibrinogen beta chain Homo sapiens 71-81 8639542-4 1996 A alpha.gamma heterodimers were identified as a component of monomeric fibrinogen by two-dimensional SDS-PAGE and by SDS-PAGE analysis of the monomer fraction isolated by gel sieving chromatography, thus indicating that A alpha.gamma heterodimers arise by intramolecular A alpha/gamma chain cross-linking. Sodium Dodecyl Sulfate 117-120 fibrinogen beta chain Homo sapiens 71-81 8769685-0 1996 Effects of pravastatin sodium and simvastatin on plasma fibrinogen level and blood rheology in type II hyperlipoproteinemia. Simvastatin 34-45 fibrinogen beta chain Homo sapiens 56-66 8769685-10 1996 From the results, we conclude that administration of pravastatin sodium, but not simvastatin, reduced the plasma fibrinogen level and blood viscosities to normal levels in type II hyperlipoproteinemic patients while both drugs reduced total cholesterol level. Pravastatin 53-71 fibrinogen beta chain Homo sapiens 113-123 9377378-3 1996 A possibility is shown of forecasting of the heparin therapy efficacy in the above patient populations in respect of a decline in the urinary excretion of products of the fibrinogen/fibrin cleavage more than two-fold a week after the start of treatment. Heparin 45-52 fibrinogen beta chain Homo sapiens 171-181 8611703-0 1996 Changes in cytosolic calcium concentrations and cell morphology in single platelets adhered to fibrinogen-coated surface under flow. Calcium 21-28 fibrinogen beta chain Homo sapiens 95-105 8611703-1 1996 Changes in intracellular calcium concentration [Ca2+]i of fura-2-loaded human platelet during its adhesion to a fibrinogen-coated surface were studied, using a flow chamber mounted on an epifluorescence microscope equipped with digital-ratio imaging. Fura-2 58-64 fibrinogen beta chain Homo sapiens 112-122 8689720-2 1996 Solid phase synthesis of fibrinogen-related peptides with disulfide bond formed on solid support. Disulfides 58-67 fibrinogen beta chain Homo sapiens 25-35 8725723-5 1996 Both fibrinogen and factor VIIag significantly correlated with total cholesterol (p < 0.05) while only fibrinogen correlated with body mass index (p < 0.01). Cholesterol 69-80 fibrinogen beta chain Homo sapiens 5-15 8725724-3 1996 125I-fibrinogen bound specifically and saturably to either cell line, and specific fibrinogen binding increased upon stimulation of these cells with proinflammatory agents such as phorbol myristate (PMA), lipopolysaccharide (LPS) or tumor necrosis factor (TNF-alpha). Phorbol 13-myristate 180-197 fibrinogen beta chain Homo sapiens 83-93 8725724-3 1996 125I-fibrinogen bound specifically and saturably to either cell line, and specific fibrinogen binding increased upon stimulation of these cells with proinflammatory agents such as phorbol myristate (PMA), lipopolysaccharide (LPS) or tumor necrosis factor (TNF-alpha). Tetradecanoylphorbol Acetate 199-202 fibrinogen beta chain Homo sapiens 83-93 8725724-5 1996 Anti-ICAM-1 antibody or antisense oligonucleotides inhibited fibrinogen-mediated cell adhesion and binding of 125I-fibrinogen to mesothelioma or mesothelial cells. Oligonucleotides 34-50 fibrinogen beta chain Homo sapiens 61-71 8725724-5 1996 Anti-ICAM-1 antibody or antisense oligonucleotides inhibited fibrinogen-mediated cell adhesion and binding of 125I-fibrinogen to mesothelioma or mesothelial cells. Oligonucleotides 34-50 fibrinogen beta chain Homo sapiens 115-125 8860710-4 1996 Lipoprotein (a), apoA-2, apoC-3, fibrinogen, and immunoglobulin M (IgM) showed significantly high removal rates by the DFPP and TFPP methods compared with the PA method. dfpp 119-123 fibrinogen beta chain Homo sapiens 33-43 8860711-2 1996 In collaboration with B. Braun Melsungen AG, Germany, we were able to develop the heparin-mediated extracorporeal low-density lipoprotein (LDL) fibrinogen precipitation (H.E.L.P.) Heparin 82-89 fibrinogen beta chain Homo sapiens 144-154 8611457-3 1996 Non-reducing SDS-PAGE of purified fibrinogen from affected individuals showed that the 340 kD form of their fibrinogen ran as a doublet. Sodium Dodecyl Sulfate 13-16 fibrinogen beta chain Homo sapiens 34-44 8611457-3 1996 Non-reducing SDS-PAGE of purified fibrinogen from affected individuals showed that the 340 kD form of their fibrinogen ran as a doublet. Sodium Dodecyl Sulfate 13-16 fibrinogen beta chain Homo sapiens 108-118 8611461-0 1996 Optimally functional fluorescein isothiocyanate-labelled fibrinogen for quantitative studies of binding to activated platelets and platelet aggregation. Fluorescein-5-isothiocyanate 21-47 fibrinogen beta chain Homo sapiens 57-67 8671552-5 1996 Plasma fibrinogen was positively associated with age and serum total cholesterol, and inversely associated with ethanol intake, dietary intake of sea foods such as squid, octopus or shrimp. Cholesterol 69-80 fibrinogen beta chain Homo sapiens 7-17 8671552-5 1996 Plasma fibrinogen was positively associated with age and serum total cholesterol, and inversely associated with ethanol intake, dietary intake of sea foods such as squid, octopus or shrimp. Ethanol 112-119 fibrinogen beta chain Homo sapiens 7-17 9112667-8 1996 On the other hand, we have found a significant reduction in the number of fibrinogen receptors exposed on the platelet surface of patients (n = 21) treated with therapeutic doses (240 mg/day) of verapamil during two weeks of drug administration. Verapamil 195-204 fibrinogen beta chain Homo sapiens 74-84 9112667-11 1996 It suggests, that in vitro exposure of platelets to verapamil for a short time has no effect on the expression of fibrinogen receptors on platelets, but prolonged in vivo interaction of this drug with platelets results in reduction of the fibrinogen receptor exposition. Verapamil 52-61 fibrinogen beta chain Homo sapiens 239-249 9163070-7 1996 Our present and previous findings suggest that soluble fibrinogen aggregates possess a fibrin-like structure, and that fibrin or fibrinogen polymer formation is a prerequisite for the enhancing effect on t-PA-mediated plasminogen to plasmin conversion which is seen even with the polymers in the soluble state. Polymers 280-288 fibrinogen beta chain Homo sapiens 55-65 9163070-7 1996 Our present and previous findings suggest that soluble fibrinogen aggregates possess a fibrin-like structure, and that fibrin or fibrinogen polymer formation is a prerequisite for the enhancing effect on t-PA-mediated plasminogen to plasmin conversion which is seen even with the polymers in the soluble state. Polymers 280-288 fibrinogen beta chain Homo sapiens 129-139 8672453-2 1996 Previous studies by several investigators have suggested that the Arg-Gly-Asp (RGD) site at position 572-574 on the alpha chain of human fibrinogen can bind to alphavbeta3. arginyl-glycyl-aspartic acid 66-77 fibrinogen beta chain Homo sapiens 137-147 8735140-0 1996 Binding of calcium ions and their effect on clotting of fibrinogen Milano III, a variant with truncated A alpha-chains. Calcium 11-18 fibrinogen beta chain Homo sapiens 56-66 8735140-2 1996 Normal human fibrinogen has three high-affinity calcium binding sites. Calcium 48-55 fibrinogen beta chain Homo sapiens 13-23 8735140-5 1996 In several abnormally clotting fibrinogen variants, the polymerisation defect was partially normalised following addition of calcium ions. Calcium 125-132 fibrinogen beta chain Homo sapiens 31-41 8735140-6 1996 In this study, we show normal binding of calcium to fibrinogen Milano III, a homozygous fibrinogen variant with truncated A alpha-chains (A alpha 452 Gly-Pro-Asp-->Trp-Ser-Stop). Calcium 41-48 fibrinogen beta chain Homo sapiens 52-62 8735140-10 1996 The polymerisation defect in fibrinogen Milano III appears to be due to truncated A alpha-chains as well as to the disulphide-linked albumin. disulphide 115-125 fibrinogen beta chain Homo sapiens 29-39 8611461-2 1996 Due to conflicting reports on the functionality of FITC-labelled Fg, we have developed a reproducible and "mild" labelling of fibrinogen with FITC-celite at pH 7.4-8.5 for direct and dynamic studies of specific Fg binding to activated platelets evaluated for native platelet-rich plasma, for washed platelets, and for activated, fixed platelets. Fluorescein-5-isothiocyanate 51-55 fibrinogen beta chain Homo sapiens 65-67 8611461-2 1996 Due to conflicting reports on the functionality of FITC-labelled Fg, we have developed a reproducible and "mild" labelling of fibrinogen with FITC-celite at pH 7.4-8.5 for direct and dynamic studies of specific Fg binding to activated platelets evaluated for native platelet-rich plasma, for washed platelets, and for activated, fixed platelets. Fluorescein-5-isothiocyanate 51-55 fibrinogen beta chain Homo sapiens 126-136 8730606-8 1996 RESULTS: Consumption for a period of four weeks of 30 g/day of alcohol either from red wine or alcohol resulted in similar decreases of collagen-induced platelet aggregation and fibrinogen levels. Alcohols 63-70 fibrinogen beta chain Homo sapiens 178-188 8611461-2 1996 Due to conflicting reports on the functionality of FITC-labelled Fg, we have developed a reproducible and "mild" labelling of fibrinogen with FITC-celite at pH 7.4-8.5 for direct and dynamic studies of specific Fg binding to activated platelets evaluated for native platelet-rich plasma, for washed platelets, and for activated, fixed platelets. fitc-celite 142-153 fibrinogen beta chain Homo sapiens 65-67 8611461-2 1996 Due to conflicting reports on the functionality of FITC-labelled Fg, we have developed a reproducible and "mild" labelling of fibrinogen with FITC-celite at pH 7.4-8.5 for direct and dynamic studies of specific Fg binding to activated platelets evaluated for native platelet-rich plasma, for washed platelets, and for activated, fixed platelets. fitc-celite 142-153 fibrinogen beta chain Homo sapiens 126-136 8611461-3 1996 We have demonstrated the equivalence of FITC-labelled and unlabelled Fg for binding to activated GPIIb-IIIa receptors, and in the rate and extent of mediating platelet aggregation. Fluorescein-5-isothiocyanate 40-44 fibrinogen beta chain Homo sapiens 69-71 8611461-4 1996 We found that FITC-Fg labelled at pH > or = 9 had reduced to absent specific binding to activated platelets, whether using soluble FITC or FITC-celite. Fluorescein-5-isothiocyanate 14-18 fibrinogen beta chain Homo sapiens 19-21 8611461-4 1996 We found that FITC-Fg labelled at pH > or = 9 had reduced to absent specific binding to activated platelets, whether using soluble FITC or FITC-celite. Fluorescein-5-isothiocyanate 134-138 fibrinogen beta chain Homo sapiens 19-21 8611461-4 1996 We found that FITC-Fg labelled at pH > or = 9 had reduced to absent specific binding to activated platelets, whether using soluble FITC or FITC-celite. fitc-celite 142-153 fibrinogen beta chain Homo sapiens 19-21 8737243-0 1996 Sulfatide prolongs blood-coagulation time and bleeding time by forming a complex with fibrinogen. Sulfoglycosphingolipids 0-9 fibrinogen beta chain Homo sapiens 86-96 8737243-2 1996 When equal volumes of a homogeneous micellar solution of sulfatide and fibrinogen in phosphate-buffered saline were mixed, an insoluble complex precipitated. Phosphate-Buffered Saline 85-110 fibrinogen beta chain Homo sapiens 71-81 8737243-3 1996 Analysis of the precipitated complex showed that the molar ratio of sulfatide to fibrinogen was about 400:1. Sulfoglycosphingolipids 68-77 fibrinogen beta chain Homo sapiens 81-91 8737243-4 1996 These results indicate that the sulfatide micelle binds tightly to fibrinogen and thereby interferes with both fibrin gel formation (anticoagulant activity) and platelet function. Sulfoglycosphingolipids 32-41 fibrinogen beta chain Homo sapiens 67-77 8726359-7 1996 NBD-CI also inhibited ADP-induced shape change, aggregation, exposure of fibrinogen binding sites, secretion, and calcium mobilization in washed platelets. Adenosine Diphosphate 22-25 fibrinogen beta chain Homo sapiens 73-83 8934767-2 1996 In order to protect fibrinogen during UVC irradiation, 0.5 mM rutin was added prior to UVC exposure and subsequently removed during processing. Rutin 62-67 fibrinogen beta chain Homo sapiens 20-30 8934767-5 1996 In the absence of rutin, UVC irradiation of fibrinogen at similar fluence led to loss of solubility, increased clot time and the cleavage of fibrino-peptides that reacted with dinitrophenyl hydrazine as a test for ketonic carbonyl groups. dinitrophenylhydrazine 176-199 fibrinogen beta chain Homo sapiens 44-54 8934767-7 1996 Experiments with 3H-rutin showed that after UVC irradiation, subsequent processing by a C18 resin and alcohol precipitation removed > 99% rutin, representing < 10 ppm rutin in the final fibrinogen preparations. Rutin 141-146 fibrinogen beta chain Homo sapiens 192-202 8630665-10 1996 Our results also show that the binding of kringle IV-10 to PM- fibrinogen is more complex than that to Lys, in that the former requires an additional binding site or sites outside the Lys-binding site. Lysine 184-187 fibrinogen beta chain Homo sapiens 63-73 8733899-11 1996 Furthermore, reduced protein, albumin and fibrinogen indicate an impaired liver synthetic function in asymptomatic children treated with VPA monotherapy. Valproic Acid 137-140 fibrinogen beta chain Homo sapiens 42-52 8701409-1 1996 Fibrinogen has been detected in ME-180 human uterine cervix carcinoma cells, and synthesis of fibrinogen by ME-180 cells has been measured using [35S] L-methionine incorporation. Methionine 151-163 fibrinogen beta chain Homo sapiens 94-104 8608226-2 1996 Fibrinogen binding exposes new antibody binding sites on GPIIb-IIIa (ligand-induced binding sites: LIBS). libs 99-103 fibrinogen beta chain Homo sapiens 0-10 8620341-7 1996 After adjustment for smoking status, blood pressure, total and HDL cholesterol, diabetes status, hematocrit, and white cell count, the association between fibrinogen and CHD was changed slightly and remained statistically significant (P < .05). Cholesterol 67-78 fibrinogen beta chain Homo sapiens 155-165 8562968-6 1996 Similarly, PMA enhanced HEL cell adhesion to immobilized fibrinogen by 10-fold. Tetradecanoylphorbol Acetate 11-14 fibrinogen beta chain Homo sapiens 57-67 10479440-0 1996 The Dual Role of Fibrinogen as Inhibitor and Nucleator of Calcium Phosphate Phases: The Importance of Structure. calcium phosphate 58-75 fibrinogen beta chain Homo sapiens 17-27 10479440-1 1996 Constant composition and free drift methods have been used to investigate the abilities of human serum albumin (HSA) and fibrinogen to influence calcium phosphate precipitation. calcium phosphate 145-162 fibrinogen beta chain Homo sapiens 97-131 10479440-3 1996 Fibrinogen, when immobilized at hydrophobicized germanium or silica surfaces, is able to nucleate calcium phosphate phases; at clean germanium or silica surfaces, it appears to be inactive. Germanium 48-57 fibrinogen beta chain Homo sapiens 0-10 10479440-3 1996 Fibrinogen, when immobilized at hydrophobicized germanium or silica surfaces, is able to nucleate calcium phosphate phases; at clean germanium or silica surfaces, it appears to be inactive. Silicon Dioxide 61-67 fibrinogen beta chain Homo sapiens 0-10 10479440-3 1996 Fibrinogen, when immobilized at hydrophobicized germanium or silica surfaces, is able to nucleate calcium phosphate phases; at clean germanium or silica surfaces, it appears to be inactive. calcium phosphate 98-115 fibrinogen beta chain Homo sapiens 0-10 10479440-3 1996 Fibrinogen, when immobilized at hydrophobicized germanium or silica surfaces, is able to nucleate calcium phosphate phases; at clean germanium or silica surfaces, it appears to be inactive. Germanium 133-142 fibrinogen beta chain Homo sapiens 0-10 10479440-3 1996 Fibrinogen, when immobilized at hydrophobicized germanium or silica surfaces, is able to nucleate calcium phosphate phases; at clean germanium or silica surfaces, it appears to be inactive. Silicon Dioxide 146-152 fibrinogen beta chain Homo sapiens 0-10 10479440-4 1996 The apparent configuration of fibrinogen molecules at germanium or silica surfaces on which octadecyltrichlorosilane (OTS) was deposited probably exposes more negative sites for participation in nucleation. Silicon Dioxide 67-73 fibrinogen beta chain Homo sapiens 30-40 10479440-4 1996 The apparent configuration of fibrinogen molecules at germanium or silica surfaces on which octadecyltrichlorosilane (OTS) was deposited probably exposes more negative sites for participation in nucleation. octadecyltrichlorosilane 92-116 fibrinogen beta chain Homo sapiens 30-40 9328624-5 1996 In conclusion, bezafibrate at a daily dose of 400 mg had significant lipid-modifying properties but also exhibited a beneficial effect on other related risk factors such as fibrinogen reduction. Bezafibrate 15-26 fibrinogen beta chain Homo sapiens 173-183 18653031-5 1996 In stroke group fibrinogen is positively correlated with systolic and diastolic blood pressure and triglyceridemia. triglyceridemia 99-114 fibrinogen beta chain Homo sapiens 16-26 8548415-4 1996 Dividing the individuals into quartiles according to their fibrinogen values showed that men within the highest fibrinogen quartile (fibrinogen 2.90 to 4.34 g/L) had significantly higher concentrations of small, dense LDL (d > 1.044 g/mL) apolipoprotein B and cholesterol and lower concentrations of HDL2 cholesterol than men within the lower fibrinogen quartiles (fibrinogen < 2.55 g/L). Cholesterol 263-274 fibrinogen beta chain Homo sapiens 112-122 8548415-4 1996 Dividing the individuals into quartiles according to their fibrinogen values showed that men within the highest fibrinogen quartile (fibrinogen 2.90 to 4.34 g/L) had significantly higher concentrations of small, dense LDL (d > 1.044 g/mL) apolipoprotein B and cholesterol and lower concentrations of HDL2 cholesterol than men within the lower fibrinogen quartiles (fibrinogen < 2.55 g/L). Cholesterol 263-274 fibrinogen beta chain Homo sapiens 112-122 8548415-4 1996 Dividing the individuals into quartiles according to their fibrinogen values showed that men within the highest fibrinogen quartile (fibrinogen 2.90 to 4.34 g/L) had significantly higher concentrations of small, dense LDL (d > 1.044 g/mL) apolipoprotein B and cholesterol and lower concentrations of HDL2 cholesterol than men within the lower fibrinogen quartiles (fibrinogen < 2.55 g/L). Cholesterol 263-274 fibrinogen beta chain Homo sapiens 112-122 8548415-4 1996 Dividing the individuals into quartiles according to their fibrinogen values showed that men within the highest fibrinogen quartile (fibrinogen 2.90 to 4.34 g/L) had significantly higher concentrations of small, dense LDL (d > 1.044 g/mL) apolipoprotein B and cholesterol and lower concentrations of HDL2 cholesterol than men within the lower fibrinogen quartiles (fibrinogen < 2.55 g/L). Cholesterol 263-274 fibrinogen beta chain Homo sapiens 112-122 8548415-4 1996 Dividing the individuals into quartiles according to their fibrinogen values showed that men within the highest fibrinogen quartile (fibrinogen 2.90 to 4.34 g/L) had significantly higher concentrations of small, dense LDL (d > 1.044 g/mL) apolipoprotein B and cholesterol and lower concentrations of HDL2 cholesterol than men within the lower fibrinogen quartiles (fibrinogen < 2.55 g/L). Cholesterol 308-319 fibrinogen beta chain Homo sapiens 112-122 8548415-4 1996 Dividing the individuals into quartiles according to their fibrinogen values showed that men within the highest fibrinogen quartile (fibrinogen 2.90 to 4.34 g/L) had significantly higher concentrations of small, dense LDL (d > 1.044 g/mL) apolipoprotein B and cholesterol and lower concentrations of HDL2 cholesterol than men within the lower fibrinogen quartiles (fibrinogen < 2.55 g/L). Cholesterol 308-319 fibrinogen beta chain Homo sapiens 112-122 8548415-4 1996 Dividing the individuals into quartiles according to their fibrinogen values showed that men within the highest fibrinogen quartile (fibrinogen 2.90 to 4.34 g/L) had significantly higher concentrations of small, dense LDL (d > 1.044 g/mL) apolipoprotein B and cholesterol and lower concentrations of HDL2 cholesterol than men within the lower fibrinogen quartiles (fibrinogen < 2.55 g/L). Cholesterol 308-319 fibrinogen beta chain Homo sapiens 112-122 8548415-4 1996 Dividing the individuals into quartiles according to their fibrinogen values showed that men within the highest fibrinogen quartile (fibrinogen 2.90 to 4.34 g/L) had significantly higher concentrations of small, dense LDL (d > 1.044 g/mL) apolipoprotein B and cholesterol and lower concentrations of HDL2 cholesterol than men within the lower fibrinogen quartiles (fibrinogen < 2.55 g/L). Cholesterol 308-319 fibrinogen beta chain Homo sapiens 112-122 8548415-5 1996 Multivariate regression analysis revealed that the association between fibrinogen and small, dense LDL particles was independent of serum triglycerides, cholesterol, body mass index, and age. Triglycerides 138-151 fibrinogen beta chain Homo sapiens 71-81 8548415-5 1996 Multivariate regression analysis revealed that the association between fibrinogen and small, dense LDL particles was independent of serum triglycerides, cholesterol, body mass index, and age. Cholesterol 153-164 fibrinogen beta chain Homo sapiens 71-81 8548415-6 1996 In contrast, the relationship between fibrinogen and HDL2 cholesterol was primarily influenced by triglycerides and cholesterol and not independently influenced by fibrinogen. Cholesterol 58-69 fibrinogen beta chain Homo sapiens 38-48 8548415-6 1996 In contrast, the relationship between fibrinogen and HDL2 cholesterol was primarily influenced by triglycerides and cholesterol and not independently influenced by fibrinogen. Triglycerides 98-111 fibrinogen beta chain Homo sapiens 38-48 8548415-6 1996 In contrast, the relationship between fibrinogen and HDL2 cholesterol was primarily influenced by triglycerides and cholesterol and not independently influenced by fibrinogen. Cholesterol 116-127 fibrinogen beta chain Homo sapiens 38-48 8788102-2 1996 Adsorbed fibrinogen at steady state decreased in the order PU-SO3 > PU > PU-PEO-SO3 > PU-PEO, suggesting that sulfonate groups have specific high affinity to fibrinogen. pu-so3 59-65 fibrinogen beta chain Homo sapiens 9-19 8788102-2 1996 Adsorbed fibrinogen at steady state decreased in the order PU-SO3 > PU > PU-PEO-SO3 > PU-PEO, suggesting that sulfonate groups have specific high affinity to fibrinogen. Plutonium 59-61 fibrinogen beta chain Homo sapiens 9-19 8788102-2 1996 Adsorbed fibrinogen at steady state decreased in the order PU-SO3 > PU > PU-PEO-SO3 > PU-PEO, suggesting that sulfonate groups have specific high affinity to fibrinogen. peo-so3 82-89 fibrinogen beta chain Homo sapiens 9-19 8788102-2 1996 Adsorbed fibrinogen at steady state decreased in the order PU-SO3 > PU > PU-PEO-SO3 > PU-PEO, suggesting that sulfonate groups have specific high affinity to fibrinogen. Polyethylene Glycols 82-85 fibrinogen beta chain Homo sapiens 9-19 8788102-2 1996 Adsorbed fibrinogen at steady state decreased in the order PU-SO3 > PU > PU-PEO-SO3 > PU-PEO, suggesting that sulfonate groups have specific high affinity to fibrinogen. sulfonate 119-128 fibrinogen beta chain Homo sapiens 9-19 8788102-2 1996 Adsorbed fibrinogen at steady state decreased in the order PU-SO3 > PU > PU-PEO-SO3 > PU-PEO, suggesting that sulfonate groups have specific high affinity to fibrinogen. sulfonate 119-128 fibrinogen beta chain Homo sapiens 167-177 8788102-3 1996 The intermediate fibrinogen adsorption on PU-PEO-SO3 can be explained by the compensatory effect between the low protein binding affinity of the PEO chain and the high fibrinogen binding affinity of the sulfonate group. sulfonate 203-212 fibrinogen beta chain Homo sapiens 17-27 8788102-3 1996 The intermediate fibrinogen adsorption on PU-PEO-SO3 can be explained by the compensatory effect between the low protein binding affinity of the PEO chain and the high fibrinogen binding affinity of the sulfonate group. sulfonate 203-212 fibrinogen beta chain Homo sapiens 168-178 8788102-4 1996 In addition, PU-PEO-SO3 showed a very fast fibrinogen adsorption due to the high accessibility of the sulfonate group to fibrinogen by the poly(ethylene oxide) (PEO) spacer. pu-peo-so3 13-23 fibrinogen beta chain Homo sapiens 43-53 8788102-4 1996 In addition, PU-PEO-SO3 showed a very fast fibrinogen adsorption due to the high accessibility of the sulfonate group to fibrinogen by the poly(ethylene oxide) (PEO) spacer. pu-peo-so3 13-23 fibrinogen beta chain Homo sapiens 121-131 8788102-4 1996 In addition, PU-PEO-SO3 showed a very fast fibrinogen adsorption due to the high accessibility of the sulfonate group to fibrinogen by the poly(ethylene oxide) (PEO) spacer. sulfonate 102-111 fibrinogen beta chain Homo sapiens 43-53 8788102-4 1996 In addition, PU-PEO-SO3 showed a very fast fibrinogen adsorption due to the high accessibility of the sulfonate group to fibrinogen by the poly(ethylene oxide) (PEO) spacer. sulfonate 102-111 fibrinogen beta chain Homo sapiens 121-131 8788102-4 1996 In addition, PU-PEO-SO3 showed a very fast fibrinogen adsorption due to the high accessibility of the sulfonate group to fibrinogen by the poly(ethylene oxide) (PEO) spacer. Polyethylene Glycols 139-159 fibrinogen beta chain Homo sapiens 43-53 8788102-4 1996 In addition, PU-PEO-SO3 showed a very fast fibrinogen adsorption due to the high accessibility of the sulfonate group to fibrinogen by the poly(ethylene oxide) (PEO) spacer. Polyethylene Glycols 139-159 fibrinogen beta chain Homo sapiens 121-131 21043648-1 1996 Human blood platelets can be activated by a variety of physiological activators such as adenosine diphosphate (ADP), thrombin or collagen, leading to activation of GPIIb-IIIa into a high-affinity receptor for Fg (FgR), binding of fibrinogen (Fg), and subsequent platelet aggregation required for normal hemostasis. Adenosine Diphosphate 88-109 fibrinogen beta chain Homo sapiens 209-211 21043648-1 1996 Human blood platelets can be activated by a variety of physiological activators such as adenosine diphosphate (ADP), thrombin or collagen, leading to activation of GPIIb-IIIa into a high-affinity receptor for Fg (FgR), binding of fibrinogen (Fg), and subsequent platelet aggregation required for normal hemostasis. Adenosine Diphosphate 88-109 fibrinogen beta chain Homo sapiens 230-240 21043648-1 1996 Human blood platelets can be activated by a variety of physiological activators such as adenosine diphosphate (ADP), thrombin or collagen, leading to activation of GPIIb-IIIa into a high-affinity receptor for Fg (FgR), binding of fibrinogen (Fg), and subsequent platelet aggregation required for normal hemostasis. Adenosine Diphosphate 88-109 fibrinogen beta chain Homo sapiens 213-215 21043648-1 1996 Human blood platelets can be activated by a variety of physiological activators such as adenosine diphosphate (ADP), thrombin or collagen, leading to activation of GPIIb-IIIa into a high-affinity receptor for Fg (FgR), binding of fibrinogen (Fg), and subsequent platelet aggregation required for normal hemostasis. Adenosine Diphosphate 111-114 fibrinogen beta chain Homo sapiens 209-211 21043648-1 1996 Human blood platelets can be activated by a variety of physiological activators such as adenosine diphosphate (ADP), thrombin or collagen, leading to activation of GPIIb-IIIa into a high-affinity receptor for Fg (FgR), binding of fibrinogen (Fg), and subsequent platelet aggregation required for normal hemostasis. Adenosine Diphosphate 111-114 fibrinogen beta chain Homo sapiens 230-240 21043648-1 1996 Human blood platelets can be activated by a variety of physiological activators such as adenosine diphosphate (ADP), thrombin or collagen, leading to activation of GPIIb-IIIa into a high-affinity receptor for Fg (FgR), binding of fibrinogen (Fg), and subsequent platelet aggregation required for normal hemostasis. Adenosine Diphosphate 111-114 fibrinogen beta chain Homo sapiens 213-215 21043648-3 1996 Since platelet activation and aggregation occur within ~1 s of stirring with activators such as ADP, a methodology was required for determining the rapid dynamics of expression of FgR and binding of Fg, and their correlation with platelet aggregation kinetics. Adenosine Diphosphate 96-99 fibrinogen beta chain Homo sapiens 180-182 21043648-9 1996 Dynamic binding studies of Fg to FgR on activated platelets has become possible using appropriately FITC-labelled Fg and flow cytometry. Fluorescein-5-isothiocyanate 100-104 fibrinogen beta chain Homo sapiens 27-29 21043648-9 1996 Dynamic binding studies of Fg to FgR on activated platelets has become possible using appropriately FITC-labelled Fg and flow cytometry. Fluorescein-5-isothiocyanate 100-104 fibrinogen beta chain Homo sapiens 33-35 8611461-5 1996 The FITC-labelled Fg must be diluted 3-fold with unlabelled Fg when evaluating maximal Fg binding to activated platelets in order to prevent autoquenching of the FITC-Fg which leads to underestimation of Fg levels. Fluorescein-5-isothiocyanate 4-8 fibrinogen beta chain Homo sapiens 18-20 8611461-5 1996 The FITC-labelled Fg must be diluted 3-fold with unlabelled Fg when evaluating maximal Fg binding to activated platelets in order to prevent autoquenching of the FITC-Fg which leads to underestimation of Fg levels. Fluorescein-5-isothiocyanate 4-8 fibrinogen beta chain Homo sapiens 60-62 8611461-5 1996 The FITC-labelled Fg must be diluted 3-fold with unlabelled Fg when evaluating maximal Fg binding to activated platelets in order to prevent autoquenching of the FITC-Fg which leads to underestimation of Fg levels. Fluorescein-5-isothiocyanate 4-8 fibrinogen beta chain Homo sapiens 60-62 8611461-5 1996 The FITC-labelled Fg must be diluted 3-fold with unlabelled Fg when evaluating maximal Fg binding to activated platelets in order to prevent autoquenching of the FITC-Fg which leads to underestimation of Fg levels. Fluorescein-5-isothiocyanate 4-8 fibrinogen beta chain Homo sapiens 60-62 8611461-5 1996 The FITC-labelled Fg must be diluted 3-fold with unlabelled Fg when evaluating maximal Fg binding to activated platelets in order to prevent autoquenching of the FITC-Fg which leads to underestimation of Fg levels. Fluorescein-5-isothiocyanate 4-8 fibrinogen beta chain Homo sapiens 60-62 8611461-5 1996 The FITC-labelled Fg must be diluted 3-fold with unlabelled Fg when evaluating maximal Fg binding to activated platelets in order to prevent autoquenching of the FITC-Fg which leads to underestimation of Fg levels. Fluorescein-5-isothiocyanate 162-166 fibrinogen beta chain Homo sapiens 18-20 8611461-6 1996 The dissociation constant (KD) of Fg on stable preparations of activated, fixed platelets, determined with FITC-Fg binding to platelets by flow cytometry, was in the range reported for 125I-labelled Fg, 70-255 nm with Bmax = 10000-25000 Fg per platelet (n = 20). Fluorescein-5-isothiocyanate 107-111 fibrinogen beta chain Homo sapiens 34-36 8847874-7 1996 Only fenofibrate, not simvastatin, decreased both fibrinogen (-10.3 vs. + 3.6%) and uric acid (-25% vs. no change) in type IIa and type IIb patients. Fenofibrate 5-16 fibrinogen beta chain Homo sapiens 50-60 8743195-4 1996 An anti GP IIb-IIIa monoclonal antibody (LJ-CP8) shown to inhibit the binding of both vWF and fibrinogen to the GP IIb-IIIa complex, had only a slight effect on the [Ca2+]i rise elicited by the addition of P-vWF. lj-cp8 41-47 fibrinogen beta chain Homo sapiens 94-104 8850552-3 1996 These sequences are nearly identical to the two human fibrinogen glycopeptides, Val-Glu-Asn(CHO)-Lys (gamma-chain), and Met-Gly-Glu-Asn(CHO)-Arg (beta-chain). Glycopeptides 65-78 fibrinogen beta chain Homo sapiens 54-64 8850552-3 1996 These sequences are nearly identical to the two human fibrinogen glycopeptides, Val-Glu-Asn(CHO)-Lys (gamma-chain), and Met-Gly-Glu-Asn(CHO)-Arg (beta-chain). CAV protocol 92-95 fibrinogen beta chain Homo sapiens 54-64 8850552-10 1996 Porcine fibrinogen represents the best source for substrates with this oligosaccharide type that can be reliably produced in multimicromole quantities. Oligosaccharides 71-86 fibrinogen beta chain Homo sapiens 8-18 8735823-5 1996 Fluorescein labelled chicken antibodies were used to detect platelet bound fibrinogen as these antibodies have advantages over mammalian antibodies in flow cytometry. Fluorescein 0-11 fibrinogen beta chain Homo sapiens 75-85 8846167-7 1996 Concomitant addition of the protein kinase C (PKC) inhibitors staurosporine or H7 suppressed monocyte adherence to immobilized fibrinogen but exerted no significant effect upon adhesion to any other surface tested. Staurosporine 62-75 fibrinogen beta chain Homo sapiens 127-137 8846167-8 1996 Stimulation of monocytes using phorbol myristate acetate resulted in increased binding of monocytes on fibrinogen but not on bovine serum albumin. Tetradecanoylphorbol Acetate 31-56 fibrinogen beta chain Homo sapiens 103-113 8846167-9 1996 When PKC activity was reduced through prolonged incubation with PMA for 16 h, a significant reduction of monocyte adhesion on fibrinogen was observed. Tetradecanoylphorbol Acetate 64-67 fibrinogen beta chain Homo sapiens 126-136 8634855-4 1996 Blood loss from heparin neutralization to 12h after surgery was correlated with platelet count, fibrinogen and ADP aggregation rate. Heparin 16-23 fibrinogen beta chain Homo sapiens 96-106 8867564-9 1996 Fibrinogen was associated with total cholesterol (r = 0.479; P = 0.037), HDL cholesterol (r = -0.467; P = 0.028), plasma triglycerides (r = 0.414; P = 0.012) and fasting plasma glucose level (r = 0.358; P = 0.032). Cholesterol 37-48 fibrinogen beta chain Homo sapiens 0-10 8867564-9 1996 Fibrinogen was associated with total cholesterol (r = 0.479; P = 0.037), HDL cholesterol (r = -0.467; P = 0.028), plasma triglycerides (r = 0.414; P = 0.012) and fasting plasma glucose level (r = 0.358; P = 0.032). Cholesterol 77-88 fibrinogen beta chain Homo sapiens 0-10 8867564-9 1996 Fibrinogen was associated with total cholesterol (r = 0.479; P = 0.037), HDL cholesterol (r = -0.467; P = 0.028), plasma triglycerides (r = 0.414; P = 0.012) and fasting plasma glucose level (r = 0.358; P = 0.032). Triglycerides 121-134 fibrinogen beta chain Homo sapiens 0-10 8867564-9 1996 Fibrinogen was associated with total cholesterol (r = 0.479; P = 0.037), HDL cholesterol (r = -0.467; P = 0.028), plasma triglycerides (r = 0.414; P = 0.012) and fasting plasma glucose level (r = 0.358; P = 0.032). Glucose 177-184 fibrinogen beta chain Homo sapiens 0-10 8677203-10 1996 However there was a negative correlation between the fibrinogen and the triglycerides concentration in sons of patients but not in the control group. Triglycerides 72-85 fibrinogen beta chain Homo sapiens 53-63 8555481-4 1996 Both beta 3 fragments blocked the participation of fibrinogen in the induction of platelet aggregation induced by adenosine diphosphate. Adenosine Diphosphate 114-135 fibrinogen beta chain Homo sapiens 51-61 8839925-4 1996 This is the basis of the model of metabolic zonation, according to which glucose release from glycogen and via gluconeogenesis, amino acid utilization and ammonia detoxification, protective metabolism, bile formation, and the synthesis of certain plasma proteins such as albumin and fibrinogen occur mainly in the periportal area, whereas glucose utilization, xenobiotic metabolism, and the formation of other plasma proteins such as alpha 1-antitrypsin or alpha-fetoprotein occur predominantly in the perivenous zone. Glucose 73-80 fibrinogen beta chain Homo sapiens 283-293 8839925-4 1996 This is the basis of the model of metabolic zonation, according to which glucose release from glycogen and via gluconeogenesis, amino acid utilization and ammonia detoxification, protective metabolism, bile formation, and the synthesis of certain plasma proteins such as albumin and fibrinogen occur mainly in the periportal area, whereas glucose utilization, xenobiotic metabolism, and the formation of other plasma proteins such as alpha 1-antitrypsin or alpha-fetoprotein occur predominantly in the perivenous zone. Glycogen 94-102 fibrinogen beta chain Homo sapiens 283-293 8731322-4 1996 Etofibrate (500mg/day) was administered for 60 days in the active phase, when lipid parameters, fibrinogen and platelet aggregation were measured. etofibrate 0-10 fibrinogen beta chain Homo sapiens 96-106 8731322-6 1996 CONCLUSION: The beneficial effects of etofibrate were observed not only on the lipid profile but also on the thrombogenic parameters measured by fibrinogen and platelet aggregation. etofibrate 38-48 fibrinogen beta chain Homo sapiens 145-155 8874799-2 1996 Flavostatin inhibited ADP-, collagen-, and thrombin receptor agonist peptide-induced platelet aggregation in human platelet-rich plasma (IC50 range: 59 to 111 nM) and blocked the binding of biotinylated human fibrinogen to purified GPIIb/IIIa with an inhibitory potency 31,000-fold higher than that of Arg-Gly-Asp-Ser (RGDS). flavostatin 0-11 fibrinogen beta chain Homo sapiens 209-219 8547637-0 1996 Protein kinase C regulates tyrosine phosphorylation of pp125FAK in platelets adherent to fibrinogen. Tyrosine 27-35 fibrinogen beta chain Homo sapiens 89-99 8547637-1 1996 Platelet adhesion to immobilized fibrinogen stimulates the induction of tyrosine phosphorylation of multiple proteins. Tyrosine 72-80 fibrinogen beta chain Homo sapiens 33-43 8767954-6 1996 Our results show increase of fibrinogen, correlated with the metabolic control of the disease, positive correlation between plasminogen, factor II, protein S and hypertriglycerides, decreased levels of protein C correlated neither with metabolic control of disease neither with disturbed lipid metabolism. hypertriglycerides 162-180 fibrinogen beta chain Homo sapiens 29-39 8996693-1 1996 Previously, we found that when fibrinogen-coated polyurethanes resided in a buffer for a period of time (the "residence time") platelet adhesion to these materials decreased. Polyurethanes 49-62 fibrinogen beta chain Homo sapiens 31-41 8996693-2 1996 Other changes in adsorbed fibrinogen such as decreases in polyclonal antibody binding and SDS elutability supported the conclusion that fibrinogen undergoes postadsorptive conformational changes. Sodium Dodecyl Sulfate 90-93 fibrinogen beta chain Homo sapiens 136-146 8996693-9 1996 The Ka was higher for M1 binding to fibrinogen adsorbed to Immulon I than to Biomer, Biospan or poly(ethylene terephthalate), suggesting that fibrinogen adsorbed to Immulon I is more platelet adhesive than fibrinogen adsorbed to the other polymers. Polymers 239-247 fibrinogen beta chain Homo sapiens 36-46 8996693-9 1996 The Ka was higher for M1 binding to fibrinogen adsorbed to Immulon I than to Biomer, Biospan or poly(ethylene terephthalate), suggesting that fibrinogen adsorbed to Immulon I is more platelet adhesive than fibrinogen adsorbed to the other polymers. Polymers 239-247 fibrinogen beta chain Homo sapiens 142-152 8996693-9 1996 The Ka was higher for M1 binding to fibrinogen adsorbed to Immulon I than to Biomer, Biospan or poly(ethylene terephthalate), suggesting that fibrinogen adsorbed to Immulon I is more platelet adhesive than fibrinogen adsorbed to the other polymers. Polymers 239-247 fibrinogen beta chain Homo sapiens 142-152 8996694-5 1996 The adsorption of albumin and fibrinogen onto nylon sheets was significantly reduced with draw ratio, suggesting the formation of well-established crystalline-amorphous microdomain structures at the surfaces. Nylons 46-51 fibrinogen beta chain Homo sapiens 30-40 10608036-1 1996 Arg-Gly-Asp (RGD)-containing peptides and the peptide unique to fibrinogen in the C-terminal domain of the gamma chain are important for fibrinogen binding to platelet membrane glycoprotein (GP) II b/III a. Arginine 0-3 fibrinogen beta chain Homo sapiens 137-147 10608036-1 1996 Arg-Gly-Asp (RGD)-containing peptides and the peptide unique to fibrinogen in the C-terminal domain of the gamma chain are important for fibrinogen binding to platelet membrane glycoprotein (GP) II b/III a. Glycine 4-7 fibrinogen beta chain Homo sapiens 137-147 10608036-1 1996 Arg-Gly-Asp (RGD)-containing peptides and the peptide unique to fibrinogen in the C-terminal domain of the gamma chain are important for fibrinogen binding to platelet membrane glycoprotein (GP) II b/III a. Aspartic Acid 8-11 fibrinogen beta chain Homo sapiens 137-147 8730606-8 1996 RESULTS: Consumption for a period of four weeks of 30 g/day of alcohol either from red wine or alcohol resulted in similar decreases of collagen-induced platelet aggregation and fibrinogen levels. Alcohols 95-102 fibrinogen beta chain Homo sapiens 178-188 8747529-0 1996 Fibrinogen Claro--another dysfunctional fibrinogen variant with gamma 275 arginine-->histidine substitution. Histidine 88-97 fibrinogen beta chain Homo sapiens 0-10 9813627-2 1996 Fibrinogen and collagen molecules adsorbed at hydrophobic surfaces as well as uncross-linked collagen fibrils induce ion binding and subsequent nucleation of calcium phosphate. calcium phosphate 158-175 fibrinogen beta chain Homo sapiens 0-10 8713799-6 1996 Activation of protein kinase C with 12-O-tetradecanoyl phorbol-13-acetate resulted in simultaneous loss of both stress fibers and fibrinogen binding. Tetradecanoylphorbol Acetate 36-73 fibrinogen beta chain Homo sapiens 130-140 8747529-0 1996 Fibrinogen Claro--another dysfunctional fibrinogen variant with gamma 275 arginine-->histidine substitution. Histidine 88-97 fibrinogen beta chain Homo sapiens 40-50 7489247-7 1995 Elevations in fibrinogen concentration (3.63 +/- 0.93 versus 2.87 +/- 0.54 g/L, P < .001) paralleled increases in blood glucose and insulin levels, estimates of insulin resistance, and blood pressure. Glucose 123-130 fibrinogen beta chain Homo sapiens 14-24 7489247-8 1995 In the offspring, in contrast to the control group, correlations between fibrinogen and metabolic-syndrome variables (ie, insulin, glucose, and waist and hip circumferences) were found. Glucose 131-138 fibrinogen beta chain Homo sapiens 73-83 8825225-0 1995 Dextran and hydroxyethyl starch interfere with fibrinogen assays. Dextrans 0-7 fibrinogen beta chain Homo sapiens 47-57 8825225-0 1995 Dextran and hydroxyethyl starch interfere with fibrinogen assays. Hydroxyethyl starch 12-31 fibrinogen beta chain Homo sapiens 47-57 8825225-1 1995 We studied the haemostatic and volume effects of synthetic plasma substitutes and Ringer"s solution in 48 surgical patients and found that the measured fibrinogen concentrations of patients receiving either dextran or hydroxyethyl starch (HES) were significantly higher than those predicted by the dilutional effects. Dextrans 207-214 fibrinogen beta chain Homo sapiens 152-162 8772235-3 1995 Human fibrinogen is saline was labeled with equimolar acridinium dissolved in dimethylformamide, and allowed to react with gel-filtered human platelets in the presence of ADP. Sodium Chloride 20-26 fibrinogen beta chain Homo sapiens 6-16 8772235-3 1995 Human fibrinogen is saline was labeled with equimolar acridinium dissolved in dimethylformamide, and allowed to react with gel-filtered human platelets in the presence of ADP. Adenosine Diphosphate 171-174 fibrinogen beta chain Homo sapiens 6-16 8772235-4 1995 Acridinium-fibrinogen binding to GPIIb/IIIa was assayed by measuring chemiluminescence emitted on addition of 0.1 N NaOH containing 0.06% H2O2 in a luminometer. Sodium Hydroxide 116-120 fibrinogen beta chain Homo sapiens 11-21 8772235-4 1995 Acridinium-fibrinogen binding to GPIIb/IIIa was assayed by measuring chemiluminescence emitted on addition of 0.1 N NaOH containing 0.06% H2O2 in a luminometer. Hydrogen Peroxide 138-142 fibrinogen beta chain Homo sapiens 11-21 8772235-6 1995 Acridinium-fibrinogen binding to human platelets was rapid and reversible, specific and saturable, and dependent on ADP concentrations. Adenosine Diphosphate 116-119 fibrinogen beta chain Homo sapiens 11-21 8928196-8 1995 In addition, CIPA occurred only when fibrinogen was added to washed platelets suspension. 3-(2-carboxyindol-3-yl)propionic acid 13-17 fibrinogen beta chain Homo sapiens 37-47 8928196-9 1995 These results indicate that CIPA is dependent on binding of fibrinogen to GPIIb/IIIa and GPIb is partly related with the reaction. 3-(2-carboxyindol-3-yl)propionic acid 28-32 fibrinogen beta chain Homo sapiens 60-70 21043593-4 1996 Nabumetone was found to cause a significant decrease in platelet-bound fibrinogen after adenosine diphosphate (ADP) activation using flow cytometry and a significant increase in IVBT when using CaCl(2) as activating substance. Nabumetone 0-10 fibrinogen beta chain Homo sapiens 71-81 21043593-4 1996 Nabumetone was found to cause a significant decrease in platelet-bound fibrinogen after adenosine diphosphate (ADP) activation using flow cytometry and a significant increase in IVBT when using CaCl(2) as activating substance. Adenosine Diphosphate 88-109 fibrinogen beta chain Homo sapiens 71-81 21043593-4 1996 Nabumetone was found to cause a significant decrease in platelet-bound fibrinogen after adenosine diphosphate (ADP) activation using flow cytometry and a significant increase in IVBT when using CaCl(2) as activating substance. Adenosine Diphosphate 111-114 fibrinogen beta chain Homo sapiens 71-81 7592883-14 1995 Subsequent high performance liquid chromatography and SDS-polyacrylamide gel electrophoresis analysis indicated fibrinogen B beta chain bound specifically to a 60-kDa surface protein. Sodium Dodecyl Sulfate 54-57 fibrinogen beta chain Homo sapiens 112-122 7592883-14 1995 Subsequent high performance liquid chromatography and SDS-polyacrylamide gel electrophoresis analysis indicated fibrinogen B beta chain bound specifically to a 60-kDa surface protein. polyacrylamide 58-72 fibrinogen beta chain Homo sapiens 112-122 8881840-11 1995 Fibrinogen reduction as a result of bezafibrate administration was dependent on starting levels. Bezafibrate 36-47 fibrinogen beta chain Homo sapiens 0-10 8557561-0 1995 Monamidocin, a novel fibrinogen receptor antagonist. monamidocin 0-11 fibrinogen beta chain Homo sapiens 21-31 8557561-3 1995 Monamidocin, a fibrinogen receptor binding inhibitor produced by Streptomyces sp. monamidocin 0-11 fibrinogen beta chain Homo sapiens 15-25 8557561-7 1995 It inhibits the binding of fibrinogen to its receptors with an IC50 of 0.022 microM and is about ten times more potent than monamidocin. monamidocin 124-135 fibrinogen beta chain Homo sapiens 27-37 7593425-4 1995 Tamoxifen treatment lowered levels of serum cholesterol by (mean +/- SE) 12 +/- 2%, low density lipoprotein cholesterol by 19 +/- 3%, and fibrinogen by 18 +/- 4% (P < 0.0001 vs. placebo for each). Tamoxifen 0-9 fibrinogen beta chain Homo sapiens 138-148 7593425-7 1995 We conclude that tamoxifen significantly reduces the levels of atherogenic lipids and fibrinogen in normal postmenopausal women. Tamoxifen 17-26 fibrinogen beta chain Homo sapiens 86-96 7595062-1 1995 Tumor necrosis factor (TNF) triggers cell spreading, release of granule constituents, and production of toxic oxygen derivatives in human neutrophils adherent to fibrinogen. Oxygen 110-116 fibrinogen beta chain Homo sapiens 162-172 7592638-3 1995 Inspection of the promoter region of the fibrinogen gamma gene revealed three hexanucleotide clusters of CTGGGA that are recognized as class II IL-6 responsive elements. hexanucleotide 78-92 fibrinogen beta chain Homo sapiens 41-51 8825225-1 1995 We studied the haemostatic and volume effects of synthetic plasma substitutes and Ringer"s solution in 48 surgical patients and found that the measured fibrinogen concentrations of patients receiving either dextran or hydroxyethyl starch (HES) were significantly higher than those predicted by the dilutional effects. Hydroxyethyl starch 218-237 fibrinogen beta chain Homo sapiens 152-162 8825225-1 1995 We studied the haemostatic and volume effects of synthetic plasma substitutes and Ringer"s solution in 48 surgical patients and found that the measured fibrinogen concentrations of patients receiving either dextran or hydroxyethyl starch (HES) were significantly higher than those predicted by the dilutional effects. Hydroxyethyl Starch Derivatives 239-242 fibrinogen beta chain Homo sapiens 152-162 8825225-9 1995 We conclude that the results of indirect fibrinogen assays should be interpreted cautiously, when HES or dextran is used for volume replacement. Hydroxyethyl Starch Derivatives 98-101 fibrinogen beta chain Homo sapiens 41-51 8825225-9 1995 We conclude that the results of indirect fibrinogen assays should be interpreted cautiously, when HES or dextran is used for volume replacement. Dextrans 105-112 fibrinogen beta chain Homo sapiens 41-51 7554180-9 1995 Residual fibrinogen levels at 90 minutes were 118 +/- 47% (mean +/- SD) of baseline with STAR and 68 +/- 42% with RTPA (P < .0005). rtpa 114-118 fibrinogen beta chain Homo sapiens 9-19 7559549-11 1995 Intracellular B beta and gamma chains, but not the A alpha chains in secreted fibrinogen, were cleaved by endoglycosidase H. Carbohydrate analysis indicated that secreted recombinant fibrinogen contained N-linked asialo-galactosylated biantennary oligosaccharide. Carbohydrates 125-137 fibrinogen beta chain Homo sapiens 183-193 7559549-11 1995 Intracellular B beta and gamma chains, but not the A alpha chains in secreted fibrinogen, were cleaved by endoglycosidase H. Carbohydrate analysis indicated that secreted recombinant fibrinogen contained N-linked asialo-galactosylated biantennary oligosaccharide. Oligosaccharides 247-262 fibrinogen beta chain Homo sapiens 183-193 7572798-6 1995 The KFA method yielded results that were consistent and provided excellent precision and accuracy allowing quantification of plasma fibrinogen in the range of 70-800 mg/dL (2-23.5 microM). CHEMBL4090167 4-7 fibrinogen beta chain Homo sapiens 132-142 7495409-2 1995 At man and dog the addition of calcium stabilized from 0.06 mM Ca2+ (2.0 molecules Ca2+/molecule Fibrinogen) certain X- Y- and D-fragments which were not or not in this extent generated by degradation without calcium. Calcium 31-38 fibrinogen beta chain Homo sapiens 97-107 7583541-0 1995 Retinoids stimulate fibrinogen production both in vitro (hepatocytes) and in vivo. Retinoids 0-9 fibrinogen beta chain Homo sapiens 20-30 7583541-2 1995 The in vitro effects of retinoids on fibrinogen synthesis were investigated in HepG2 cells and primary human hepatocytes. Retinoids 24-33 fibrinogen beta chain Homo sapiens 37-47 7583541-4 1995 In HepG2 cells, maximal stimulation (twofold) of fibrinogen secretion was obtained when cells were incubated in the presence of 1 mumol/L all-trans retinoic acid (T-RA) for 24 hours. Tretinoin 138-161 fibrinogen beta chain Homo sapiens 49-59 7583541-4 1995 In HepG2 cells, maximal stimulation (twofold) of fibrinogen secretion was obtained when cells were incubated in the presence of 1 mumol/L all-trans retinoic acid (T-RA) for 24 hours. Tretinoin 163-167 fibrinogen beta chain Homo sapiens 49-59 7583541-6 1995 In primary cultures of human hepatocytes, treatment with 1 mumol/L T-RA for 72 hours also gave a twofold increase in fibrinogen production. Tretinoin 67-71 fibrinogen beta chain Homo sapiens 117-127 7572798-7 1995 The determination of fibrinogen by the KFA method was not adversely affected using plasma from patients treated with heparin and those undergoing coumarin therapy. CHEMBL4090167 39-42 fibrinogen beta chain Homo sapiens 21-31 7559795-0 1995 Influences of silicates and carnitine-silicate mixtures on the inhibition of aggregation of erythrocytes elicited by the presence of fibrinogen. Silicates 14-23 fibrinogen beta chain Homo sapiens 133-143 7559795-0 1995 Influences of silicates and carnitine-silicate mixtures on the inhibition of aggregation of erythrocytes elicited by the presence of fibrinogen. Carnitine 28-37 fibrinogen beta chain Homo sapiens 133-143 7559795-0 1995 Influences of silicates and carnitine-silicate mixtures on the inhibition of aggregation of erythrocytes elicited by the presence of fibrinogen. Silicates 14-22 fibrinogen beta chain Homo sapiens 133-143 7583541-8 1995 A selective retinoic X receptor (RXR) agonist, 4-[1-3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)-ethenyl]benzoi c acid (3-methyl TTNEB), as well as 9-cis retinoic acid, a natural RXR ligand, mimicked the effects of T-RA on fibrinogen synthesis in vitro at lower concentrations. 4-[1-3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)-ethenyl]benzoi c acid 47-126 fibrinogen beta chain Homo sapiens 231-241 7583541-10 1995 The ED50 of the different retinoids on fibrinogen secretion by HepG2 cells was 25 nmol/L for T-RA, 4 nmol/L for 9-cis retinoic acid, 11 nmol/L for the synthetic RXR agonist, and > 500 nmol/L for the RAR alpha agonist. Retinoids 26-35 fibrinogen beta chain Homo sapiens 39-49 7583541-10 1995 The ED50 of the different retinoids on fibrinogen secretion by HepG2 cells was 25 nmol/L for T-RA, 4 nmol/L for 9-cis retinoic acid, 11 nmol/L for the synthetic RXR agonist, and > 500 nmol/L for the RAR alpha agonist. Tretinoin 93-97 fibrinogen beta chain Homo sapiens 39-49 7583541-10 1995 The ED50 of the different retinoids on fibrinogen secretion by HepG2 cells was 25 nmol/L for T-RA, 4 nmol/L for 9-cis retinoic acid, 11 nmol/L for the synthetic RXR agonist, and > 500 nmol/L for the RAR alpha agonist. Alitretinoin 112-131 fibrinogen beta chain Homo sapiens 39-49 8578540-2 1995 In the present study we have examined the effects of various fatty acids, the PUFAs and the saturated fatty acid palmitic acid (PA), alone or combined with the antioxidant vitamin E (Vit.E), on the fibrinogen concentration in the growth medium of human hepatoma (HepG2) cells. Fatty Acids 92-112 fibrinogen beta chain Homo sapiens 198-208 8578540-2 1995 In the present study we have examined the effects of various fatty acids, the PUFAs and the saturated fatty acid palmitic acid (PA), alone or combined with the antioxidant vitamin E (Vit.E), on the fibrinogen concentration in the growth medium of human hepatoma (HepG2) cells. Palmitic Acid 113-126 fibrinogen beta chain Homo sapiens 198-208 8578540-2 1995 In the present study we have examined the effects of various fatty acids, the PUFAs and the saturated fatty acid palmitic acid (PA), alone or combined with the antioxidant vitamin E (Vit.E), on the fibrinogen concentration in the growth medium of human hepatoma (HepG2) cells. Palmitic Acid 128-130 fibrinogen beta chain Homo sapiens 198-208 8578540-2 1995 In the present study we have examined the effects of various fatty acids, the PUFAs and the saturated fatty acid palmitic acid (PA), alone or combined with the antioxidant vitamin E (Vit.E), on the fibrinogen concentration in the growth medium of human hepatoma (HepG2) cells. Vitamin E 172-181 fibrinogen beta chain Homo sapiens 198-208 8578540-4 1995 EPA and Vit.E decreased the amount of fibrinogen additively. Eicosapentaenoic Acid 0-3 fibrinogen beta chain Homo sapiens 38-48 7677179-4 1995 When fluorescein isothiocyanate (FITC)-streptavidin was added to ADP-stimulated platelets 1 minute after biotinylated fibrinogen binding at 22 degrees C, bound fibrinogen was found in variously sized patches on the cell surface. Fluorescein-5-isothiocyanate 5-31 fibrinogen beta chain Homo sapiens 160-170 7677179-4 1995 When fluorescein isothiocyanate (FITC)-streptavidin was added to ADP-stimulated platelets 1 minute after biotinylated fibrinogen binding at 22 degrees C, bound fibrinogen was found in variously sized patches on the cell surface. Fluorescein-5-isothiocyanate 33-37 fibrinogen beta chain Homo sapiens 118-128 7677179-4 1995 When fluorescein isothiocyanate (FITC)-streptavidin was added to ADP-stimulated platelets 1 minute after biotinylated fibrinogen binding at 22 degrees C, bound fibrinogen was found in variously sized patches on the cell surface. Fluorescein-5-isothiocyanate 33-37 fibrinogen beta chain Homo sapiens 160-170 7677179-4 1995 When fluorescein isothiocyanate (FITC)-streptavidin was added to ADP-stimulated platelets 1 minute after biotinylated fibrinogen binding at 22 degrees C, bound fibrinogen was found in variously sized patches on the cell surface. Adenosine Diphosphate 65-68 fibrinogen beta chain Homo sapiens 118-128 7677179-4 1995 When fluorescein isothiocyanate (FITC)-streptavidin was added to ADP-stimulated platelets 1 minute after biotinylated fibrinogen binding at 22 degrees C, bound fibrinogen was found in variously sized patches on the cell surface. Adenosine Diphosphate 65-68 fibrinogen beta chain Homo sapiens 160-170 7677179-7 1995 Additional studies using either biotinylated fibrinogen that had been prelabeled with FITC-streptavidin or FITC-labeled fibrinogen revealed similar patterns of platelet-associated fibrinogen clearance and redistribution. Fluorescein-5-isothiocyanate 86-90 fibrinogen beta chain Homo sapiens 45-55 7677179-7 1995 Additional studies using either biotinylated fibrinogen that had been prelabeled with FITC-streptavidin or FITC-labeled fibrinogen revealed similar patterns of platelet-associated fibrinogen clearance and redistribution. Fluorescein-5-isothiocyanate 107-111 fibrinogen beta chain Homo sapiens 120-130 7677179-7 1995 Additional studies using either biotinylated fibrinogen that had been prelabeled with FITC-streptavidin or FITC-labeled fibrinogen revealed similar patterns of platelet-associated fibrinogen clearance and redistribution. Fluorescein-5-isothiocyanate 107-111 fibrinogen beta chain Homo sapiens 120-130 7677179-9 1995 Dual labeling experiments using biotinylated fibrinogen and FITC-streptavidin as well as a monoclonal anti-GPIIIa antibody labeled with rhodamine-conjugated anti-mouse IgG demonstrated the co-localization of fibrinogen and GPIIIa. Rhodamines 136-145 fibrinogen beta chain Homo sapiens 208-218 7677179-12 1995 Since surface-cleared fibrinogen was accessible to exogenous FITC-streptavidin under conditions that did not lead to platelet permeabilization, the data suggest fibrinogen deposition in compartments that are accessible to the extracellular milieu. Fluorescein-5-isothiocyanate 61-65 fibrinogen beta chain Homo sapiens 22-32 7677179-12 1995 Since surface-cleared fibrinogen was accessible to exogenous FITC-streptavidin under conditions that did not lead to platelet permeabilization, the data suggest fibrinogen deposition in compartments that are accessible to the extracellular milieu. Fluorescein-5-isothiocyanate 61-65 fibrinogen beta chain Homo sapiens 161-171 8541521-6 1995 The presence of dextran T40 in clotted fibrinogen solutions changes the clot impedance by increasing clot permeability and decreasing clot viscoelasticity. Dextrans 16-27 fibrinogen beta chain Homo sapiens 39-49 8580253-10 1995 There it was shown that the adhesion and activation of platelets on polyurethaneureas was not simply dependent on the total amount of adsorbed fibrinogen but rather on its conformation, indicated by the binding of the monoclonal antibody directed vs the gamma-chain of fibrinogen. polyetherurethane urea 68-85 fibrinogen beta chain Homo sapiens 143-153 8580253-10 1995 There it was shown that the adhesion and activation of platelets on polyurethaneureas was not simply dependent on the total amount of adsorbed fibrinogen but rather on its conformation, indicated by the binding of the monoclonal antibody directed vs the gamma-chain of fibrinogen. polyetherurethane urea 68-85 fibrinogen beta chain Homo sapiens 269-279 8591827-9 1995 We also show relationships between LDL-cholesterol and fibrinogen and the proinsulin-like molecules. Cholesterol 39-50 fibrinogen beta chain Homo sapiens 55-65 7543886-13 1995 The enzyme hydrolyzes N-succinyl-L-Ala-L-Ala-L-Pro-L-Phe-p-nitroaniline (SAAPFNA, a typical chymotrypsin substrate) at a high rate and several proteins, such as calf thymus histone, human plasma fibrinogen, milk caseins, and gelatin. n-succinyl-l-ala-l-ala-l-pro-l-phe-p-nitroaniline 22-71 fibrinogen beta chain Homo sapiens 195-205 7543886-13 1995 The enzyme hydrolyzes N-succinyl-L-Ala-L-Ala-L-Pro-L-Phe-p-nitroaniline (SAAPFNA, a typical chymotrypsin substrate) at a high rate and several proteins, such as calf thymus histone, human plasma fibrinogen, milk caseins, and gelatin. saapfna 73-80 fibrinogen beta chain Homo sapiens 195-205 8847680-5 1995 Nicotine significantly lowered plasma fibrinogen but did not affect markers of platelet activation, endothelial damage, white cell count and serum lipids. Nicotine 0-8 fibrinogen beta chain Homo sapiens 38-48 7580763-8 1995 An estimate of liver protein synthesis was made by measuring the incorporation of the 15N label into plasma fibrinogen. 15n 86-89 fibrinogen beta chain Homo sapiens 108-118 7580763-9 1995 The 15N enrichment of fibrinogen glycine and the hippurate precursor for fibrinogen were decreased significantly. 15n 4-7 fibrinogen beta chain Homo sapiens 22-32 7580763-9 1995 The 15N enrichment of fibrinogen glycine and the hippurate precursor for fibrinogen were decreased significantly. 15n 4-7 fibrinogen beta chain Homo sapiens 73-83 7580763-9 1995 The 15N enrichment of fibrinogen glycine and the hippurate precursor for fibrinogen were decreased significantly. Glycine 33-40 fibrinogen beta chain Homo sapiens 22-32 7580763-9 1995 The 15N enrichment of fibrinogen glycine and the hippurate precursor for fibrinogen were decreased significantly. hippuric acid 49-58 fibrinogen beta chain Homo sapiens 73-83 7580763-11 1995 Although further investigation is needed to elucidate the mechanism, the decrease in the incorporation of 15N glycine into fibrinogen suggests alteration in liver nitrogen metabolism at 0.56 MPa. 15n glycine 106-117 fibrinogen beta chain Homo sapiens 123-133 7580763-11 1995 Although further investigation is needed to elucidate the mechanism, the decrease in the incorporation of 15N glycine into fibrinogen suggests alteration in liver nitrogen metabolism at 0.56 MPa. Nitrogen 163-171 fibrinogen beta chain Homo sapiens 123-133 7642629-6 1995 Radioiodinated fibulin-1 was shown to bind to Fg transferred onto nitrocellulose filters after SDS-polyacrylamide gel electrophoresis. Sodium Dodecyl Sulfate 95-98 fibrinogen beta chain Homo sapiens 46-48 7642629-6 1995 Radioiodinated fibulin-1 was shown to bind to Fg transferred onto nitrocellulose filters after SDS-polyacrylamide gel electrophoresis. polyacrylamide 99-113 fibrinogen beta chain Homo sapiens 46-48 7482443-1 1995 Polyethylene glycol(PEG) was used to precipitate fibrinogen to prepare defibrinated plasma in the two stage clotting assay of antithrombin activity. Polyethylene Glycols 0-19 fibrinogen beta chain Homo sapiens 49-59 7482443-1 1995 Polyethylene glycol(PEG) was used to precipitate fibrinogen to prepare defibrinated plasma in the two stage clotting assay of antithrombin activity. Polyethylene Glycols 20-23 fibrinogen beta chain Homo sapiens 49-59 7482443-2 1995 Five percent PEG-8000 precipitated fibrinogen from plasma without loss of antithrombin activity in the defibrinated plasma. polyethylene glycol 8000 13-21 fibrinogen beta chain Homo sapiens 35-45 7575779-9 1995 In this recent group, patients maintained on prednisolone and azathioprine alone had significantly lower fibrinogen levels than those receiving cyA. Prednisolone 45-57 fibrinogen beta chain Homo sapiens 105-115 7575779-9 1995 In this recent group, patients maintained on prednisolone and azathioprine alone had significantly lower fibrinogen levels than those receiving cyA. Azathioprine 62-74 fibrinogen beta chain Homo sapiens 105-115 7639518-0 1995 Role of carbohydrates in oxidative modification of fibrinogen and other plasma proteins. Carbohydrates 8-21 fibrinogen beta chain Homo sapiens 51-61 7669656-12 1995 Furthermore, GPRP peptide which CD11c/CD18 recognizes on the A alpha-chain of fibrinogen also strongly inhibited the platelet-induced CL of neutrophils, whereas control peptides such as Gly-His-Arg-Pro (GHRP) or Gly-Pro-Gly-Gly (GPGG) had no effect. glycylhistidine 186-193 fibrinogen beta chain Homo sapiens 78-88 7669656-12 1995 Furthermore, GPRP peptide which CD11c/CD18 recognizes on the A alpha-chain of fibrinogen also strongly inhibited the platelet-induced CL of neutrophils, whereas control peptides such as Gly-His-Arg-Pro (GHRP) or Gly-Pro-Gly-Gly (GPGG) had no effect. arginylproline 194-201 fibrinogen beta chain Homo sapiens 78-88 7669656-12 1995 Furthermore, GPRP peptide which CD11c/CD18 recognizes on the A alpha-chain of fibrinogen also strongly inhibited the platelet-induced CL of neutrophils, whereas control peptides such as Gly-His-Arg-Pro (GHRP) or Gly-Pro-Gly-Gly (GPGG) had no effect. glycyl-histidyl-arginyl-proline 203-207 fibrinogen beta chain Homo sapiens 78-88 7669656-12 1995 Furthermore, GPRP peptide which CD11c/CD18 recognizes on the A alpha-chain of fibrinogen also strongly inhibited the platelet-induced CL of neutrophils, whereas control peptides such as Gly-His-Arg-Pro (GHRP) or Gly-Pro-Gly-Gly (GPGG) had no effect. glycyl-prolyl-glycyl-glycine 212-227 fibrinogen beta chain Homo sapiens 78-88 7669656-12 1995 Furthermore, GPRP peptide which CD11c/CD18 recognizes on the A alpha-chain of fibrinogen also strongly inhibited the platelet-induced CL of neutrophils, whereas control peptides such as Gly-His-Arg-Pro (GHRP) or Gly-Pro-Gly-Gly (GPGG) had no effect. glycyl-prolyl-glycyl-glycine 229-233 fibrinogen beta chain Homo sapiens 78-88 8533119-2 1995 To determine if phenytoin lowers fibrinogen levels we measured plasma fibrinogen levels in a subset of participants enrolled in a randomized, placebo-controlled, double-blind clinical trial. Phenytoin 16-25 fibrinogen beta chain Homo sapiens 33-43 8533119-5 1995 The phenytoin-treated subjects with post-treatment measurements had a 0.24 g/l (8%) reduction in mean fibrinogen levels compared to placebo (p = 0.3). Phenytoin 4-13 fibrinogen beta chain Homo sapiens 102-112 8585011-9 1995 FITC-fibrinogen could be copolymerized with recalcified platelet poor plasma (isolated from citrated whole blood) to yield fibrin that was fluorogenic. Fluorescein-5-isothiocyanate 0-4 fibrinogen beta chain Homo sapiens 5-15 8573830-5 1995 Conformational change of adsorbed fibrinogen was measured by exposing the fibrinogen preadsorbed polyurethane to three anti-fibrinogen monoclonal antibodies; the 134B-29 detectable alpha 566-580 domain of fibrinogen was increased with increasing concentration of adsorbed fibrinogen, whereas the other two fibrinogen domains were almost saturated when increasing the concentration of adsorbed fibrinogen. Polyurethanes 97-109 fibrinogen beta chain Homo sapiens 34-44 8573830-5 1995 Conformational change of adsorbed fibrinogen was measured by exposing the fibrinogen preadsorbed polyurethane to three anti-fibrinogen monoclonal antibodies; the 134B-29 detectable alpha 566-580 domain of fibrinogen was increased with increasing concentration of adsorbed fibrinogen, whereas the other two fibrinogen domains were almost saturated when increasing the concentration of adsorbed fibrinogen. Polyurethanes 97-109 fibrinogen beta chain Homo sapiens 74-84 8573830-5 1995 Conformational change of adsorbed fibrinogen was measured by exposing the fibrinogen preadsorbed polyurethane to three anti-fibrinogen monoclonal antibodies; the 134B-29 detectable alpha 566-580 domain of fibrinogen was increased with increasing concentration of adsorbed fibrinogen, whereas the other two fibrinogen domains were almost saturated when increasing the concentration of adsorbed fibrinogen. Polyurethanes 97-109 fibrinogen beta chain Homo sapiens 74-84 8573830-5 1995 Conformational change of adsorbed fibrinogen was measured by exposing the fibrinogen preadsorbed polyurethane to three anti-fibrinogen monoclonal antibodies; the 134B-29 detectable alpha 566-580 domain of fibrinogen was increased with increasing concentration of adsorbed fibrinogen, whereas the other two fibrinogen domains were almost saturated when increasing the concentration of adsorbed fibrinogen. Polyurethanes 97-109 fibrinogen beta chain Homo sapiens 74-84 8573830-5 1995 Conformational change of adsorbed fibrinogen was measured by exposing the fibrinogen preadsorbed polyurethane to three anti-fibrinogen monoclonal antibodies; the 134B-29 detectable alpha 566-580 domain of fibrinogen was increased with increasing concentration of adsorbed fibrinogen, whereas the other two fibrinogen domains were almost saturated when increasing the concentration of adsorbed fibrinogen. Polyurethanes 97-109 fibrinogen beta chain Homo sapiens 74-84 8573830-5 1995 Conformational change of adsorbed fibrinogen was measured by exposing the fibrinogen preadsorbed polyurethane to three anti-fibrinogen monoclonal antibodies; the 134B-29 detectable alpha 566-580 domain of fibrinogen was increased with increasing concentration of adsorbed fibrinogen, whereas the other two fibrinogen domains were almost saturated when increasing the concentration of adsorbed fibrinogen. Polyurethanes 97-109 fibrinogen beta chain Homo sapiens 74-84 8573830-5 1995 Conformational change of adsorbed fibrinogen was measured by exposing the fibrinogen preadsorbed polyurethane to three anti-fibrinogen monoclonal antibodies; the 134B-29 detectable alpha 566-580 domain of fibrinogen was increased with increasing concentration of adsorbed fibrinogen, whereas the other two fibrinogen domains were almost saturated when increasing the concentration of adsorbed fibrinogen. Polyurethanes 97-109 fibrinogen beta chain Homo sapiens 74-84 8573830-7 1995 Results of in vivo plasma protein adsorption on polyurethane surfaces disclosed that the adsorbed amount of fibrinogen, as well as albumin and globulin, was also decreased with increasing shear rate. Polyurethanes 48-60 fibrinogen beta chain Homo sapiens 108-118 8573830-9 1995 The monoclonal antibody 134B-29 against the 566-580 domain of fibrinogen was the most reactive with the fibrinogen adsorbed on polyurethane surfaces in this experiment. Polyurethanes 127-139 fibrinogen beta chain Homo sapiens 62-72 8573830-9 1995 The monoclonal antibody 134B-29 against the 566-580 domain of fibrinogen was the most reactive with the fibrinogen adsorbed on polyurethane surfaces in this experiment. Polyurethanes 127-139 fibrinogen beta chain Homo sapiens 104-114 8846432-4 1995 We have characterized NK receptor mediated plasma extravasation in guinea pig airways, using 125I-labelled human fibrinogen as a marker for leakage. Iodine-125 93-97 fibrinogen beta chain Homo sapiens 113-123 7557654-0 1995 Unstimulated and thrombin-stimulated platelets binding to immobilized fibrinogen and fibrin on polystyrene supports. Polystyrenes 95-106 fibrinogen beta chain Homo sapiens 70-80 7557654-2 1995 The amount of fibrinogen bound to the polystyrene support was 2 micrograms/tube, which represents 2.35 micrograms/cm2. Polystyrenes 38-49 fibrinogen beta chain Homo sapiens 14-24 7630226-8 1995 RESULTS: Serum fibrinogen levels correlated positively with LDL-cholesterol and with the body mass index and negatively with HDL-cholesterol. Cholesterol 64-75 fibrinogen beta chain Homo sapiens 15-25 7630226-8 1995 RESULTS: Serum fibrinogen levels correlated positively with LDL-cholesterol and with the body mass index and negatively with HDL-cholesterol. Cholesterol 129-140 fibrinogen beta chain Homo sapiens 15-25 7582863-3 1995 The PTPH has been applied to the manual determination of fibrinogen (FBG) with the same thrombopalstin injection as the prothrombin time (PT). thrombopalstin 88-102 fibrinogen beta chain Homo sapiens 57-67 8578445-4 1995 Several substrates (fibrinogen, thrombin receptor, heparin cofactor II) or ligands (thrombomodulin, glycoprotein Ib) interact with a large exosite located on the surface of the loop segment 65-76, mainly constituted of basic amino acids, designated anion binding exosite 1. Amino Acids, Basic 219-236 fibrinogen beta chain Homo sapiens 20-30 7787643-1 1995 OBJECTIVE: To examine the hypothesis that the increase in fibrinogen concentration and respiratory infections in winter is related to seasonal variations in vitamin C status (assessed with serum ascorbate concentration). Ascorbic Acid 157-166 fibrinogen beta chain Homo sapiens 58-68 7787643-1 1995 OBJECTIVE: To examine the hypothesis that the increase in fibrinogen concentration and respiratory infections in winter is related to seasonal variations in vitamin C status (assessed with serum ascorbate concentration). Ascorbic Acid 195-204 fibrinogen beta chain Homo sapiens 58-68 7787643-7 1995 Serum ascorbate concentration was strongly inversely related to haemostatic factors fibrinogen and factor VIIC as well as to acute phase proteins but not to self reported respiratory symptoms or neutrophil count. Ascorbic Acid 6-15 fibrinogen beta chain Homo sapiens 84-94 7787643-9 1995 An increase in dietary vitamin C of 60 mg daily (about one orange) was associated with a decrease in fibrinogen concentrations of 0.15 g/l, equivalent (according to prospective studies) to a decline of approximately 10% in risk of ischaemic heart disease. Ascorbic Acid 23-32 fibrinogen beta chain Homo sapiens 101-111 7794259-4 1995 Eristostatin, an antagonist of fibrinogen binding to platelet integrin, completely blocks platelet aggregation without inhibiting phosphoinositide 3-kinase or phospholipase C. We suggest that lysophosphatidic acid, in activating phosphoinositide 3-kinase, promotes platelet aggregation, but that platelet aggregation in response to lysophosphatidic acid does not significantly enhance phosphoinositide 3-kinase activation. eristostatin 0-12 fibrinogen beta chain Homo sapiens 31-41 7794259-4 1995 Eristostatin, an antagonist of fibrinogen binding to platelet integrin, completely blocks platelet aggregation without inhibiting phosphoinositide 3-kinase or phospholipase C. We suggest that lysophosphatidic acid, in activating phosphoinositide 3-kinase, promotes platelet aggregation, but that platelet aggregation in response to lysophosphatidic acid does not significantly enhance phosphoinositide 3-kinase activation. lysophosphatidic acid 192-213 fibrinogen beta chain Homo sapiens 31-41 15714754-1 1995 In the last stage of fibrinogen synthesis, two Aalpha-Bbeta-gamma half-molecules are disulfide linked in their N-terminal regions to form a dimeric fibrinogen molecule. Disulfides 85-94 fibrinogen beta chain Homo sapiens 21-31 15714754-1 1995 In the last stage of fibrinogen synthesis, two Aalpha-Bbeta-gamma half-molecules are disulfide linked in their N-terminal regions to form a dimeric fibrinogen molecule. Disulfides 85-94 fibrinogen beta chain Homo sapiens 148-158 7773735-2 1995 The quantity of fibrinogen that binds to cholesterol- or lecithin-coated beads decreases as the surface concentration of the lipid increases; densely packed films lecithin bind little,if any, if the protein. Lecithins 57-65 fibrinogen beta chain Homo sapiens 16-26 7773735-1 1995 Fibrinogen, the precursor of the blood clot matrix and a major constituent of atherosclerotic lesions, is shown to adsorb with high affinity to hydrophobic beads coated with cholesteryl oleate, cholesterol, or loosely packed lecithin. cholesteryl oleate 174-192 fibrinogen beta chain Homo sapiens 0-10 7773735-1 1995 Fibrinogen, the precursor of the blood clot matrix and a major constituent of atherosclerotic lesions, is shown to adsorb with high affinity to hydrophobic beads coated with cholesteryl oleate, cholesterol, or loosely packed lecithin. Cholesterol 194-205 fibrinogen beta chain Homo sapiens 0-10 7773735-1 1995 Fibrinogen, the precursor of the blood clot matrix and a major constituent of atherosclerotic lesions, is shown to adsorb with high affinity to hydrophobic beads coated with cholesteryl oleate, cholesterol, or loosely packed lecithin. Lecithins 225-233 fibrinogen beta chain Homo sapiens 0-10 7773735-2 1995 The quantity of fibrinogen that binds to cholesterol- or lecithin-coated beads decreases as the surface concentration of the lipid increases; densely packed films lecithin bind little,if any, if the protein. Cholesterol 41-52 fibrinogen beta chain Homo sapiens 16-26 7773735-3 1995 In sharp contrast, the appreciable quantity of fibrinogen that binds to cholesteryl oleate-coated beads is indifferent to the surface concentration of that lipid. cholesteryl oleate 72-90 fibrinogen beta chain Homo sapiens 47-57 7773735-4 1995 Not unexpectedly, the quantity of fibrinogen that binds to beads coated with mixtures of cholesteryl oleate and lecithin increases with increasing concentration of the cholesteryl ester. cholesteryl oleate 89-107 fibrinogen beta chain Homo sapiens 34-44 7773735-4 1995 Not unexpectedly, the quantity of fibrinogen that binds to beads coated with mixtures of cholesteryl oleate and lecithin increases with increasing concentration of the cholesteryl ester. Lecithins 112-120 fibrinogen beta chain Homo sapiens 34-44 7773735-4 1995 Not unexpectedly, the quantity of fibrinogen that binds to beads coated with mixtures of cholesteryl oleate and lecithin increases with increasing concentration of the cholesteryl ester. Cholesterol Esters 168-185 fibrinogen beta chain Homo sapiens 34-44 7773735-6 1995 These results indicate that hydrophobic, atheromatous lipid surfaces, particularly those rich in cholesteryl esters, may be predisposed to thrombosis by virtue of their inherent capacity to bind functional fibrinogen. Cholesterol Esters 97-115 fibrinogen beta chain Homo sapiens 206-216 7626351-2 1995 To investigate the effects of introducing warfarin in patients with atrial fibrillation on fibrinogen and D- dimer levels. Warfarin 42-50 fibrinogen beta chain Homo sapiens 91-101 7788603-9 1995 MAIN OUTCOME MEASURE: Monitoring for DVT by duplex ultrasonography or iodine-125-labelled-fibrinogen scanning, whichever could be applied. Iodine-125 70-80 fibrinogen beta chain Homo sapiens 90-100 7641602-6 1995 Agents that interact between GPIIb/IIIa and fibrinogen have been developed, which block GPIIb/IIIa, such as monoclonal antibodies to GPIIb/IIIa, and natural and synthetic peptides (disintegrins) containing the Arg-Gly-Asp (RGD) recognition sequence in fibrinogen and other adhesion macromolecules. Peptides 171-179 fibrinogen beta chain Homo sapiens 35-54 7641602-6 1995 Agents that interact between GPIIb/IIIa and fibrinogen have been developed, which block GPIIb/IIIa, such as monoclonal antibodies to GPIIb/IIIa, and natural and synthetic peptides (disintegrins) containing the Arg-Gly-Asp (RGD) recognition sequence in fibrinogen and other adhesion macromolecules. Peptides 171-179 fibrinogen beta chain Homo sapiens 44-54 7641602-6 1995 Agents that interact between GPIIb/IIIa and fibrinogen have been developed, which block GPIIb/IIIa, such as monoclonal antibodies to GPIIb/IIIa, and natural and synthetic peptides (disintegrins) containing the Arg-Gly-Asp (RGD) recognition sequence in fibrinogen and other adhesion macromolecules. arginyl-glycyl-aspartic acid 210-221 fibrinogen beta chain Homo sapiens 35-54 7641602-6 1995 Agents that interact between GPIIb/IIIa and fibrinogen have been developed, which block GPIIb/IIIa, such as monoclonal antibodies to GPIIb/IIIa, and natural and synthetic peptides (disintegrins) containing the Arg-Gly-Asp (RGD) recognition sequence in fibrinogen and other adhesion macromolecules. arginyl-glycyl-aspartic acid 210-221 fibrinogen beta chain Homo sapiens 44-54 7593010-1 1995 The state of fibrinogen adsorbed on untreated and glow-discharge-treated surfaces was examined by measuring platelet adhesion, monoclonal antibody (mAb) binding, the amount of fibrinogen adsorbed, and the amount of adsorbed fibrinogen which could be eluted with sodium dodecyl sulfate (SDS). Sodium Dodecyl Sulfate 262-284 fibrinogen beta chain Homo sapiens 13-23 7593010-1 1995 The state of fibrinogen adsorbed on untreated and glow-discharge-treated surfaces was examined by measuring platelet adhesion, monoclonal antibody (mAb) binding, the amount of fibrinogen adsorbed, and the amount of adsorbed fibrinogen which could be eluted with sodium dodecyl sulfate (SDS). Sodium Dodecyl Sulfate 286-289 fibrinogen beta chain Homo sapiens 13-23 7593010-2 1995 Tetrafluoroethylene (TFE) glow-discharge-treated polymers have a lower surface free energy (in air) and retain a larger fraction of adsorbed fibrinogen than untreated surfaces after SDS elution. tetrafluoroethylene 0-19 fibrinogen beta chain Homo sapiens 141-151 7593010-2 1995 Tetrafluoroethylene (TFE) glow-discharge-treated polymers have a lower surface free energy (in air) and retain a larger fraction of adsorbed fibrinogen than untreated surfaces after SDS elution. tetrafluoroethylene 21-24 fibrinogen beta chain Homo sapiens 141-151 7593010-3 1995 Platelet adhesion was lowest on the TFE-treated surfaces which retain the highest amounts of fibrinogen after SDS elution. tetrafluoroethylene 36-39 fibrinogen beta chain Homo sapiens 93-103 7593010-3 1995 Platelet adhesion was lowest on the TFE-treated surfaces which retain the highest amounts of fibrinogen after SDS elution. Sodium Dodecyl Sulfate 110-113 fibrinogen beta chain Homo sapiens 93-103 7593010-4 1995 Fibrinogen may undergo unfolding or spreading on the TFE-treated surfaces to minimize interfacial free energy (in water) and maximize protein-surface interactions. Water 114-119 fibrinogen beta chain Homo sapiens 0-10 7593010-5 1995 When it is adsorbed on the TFE-treated surfaces, fibrinogen evidently assumes a state which somehow prevents its recognition and binding by platelet receptors. tetrafluoroethylene 27-30 fibrinogen beta chain Homo sapiens 49-59 7593010-8 1995 For fibrinogen adsorbed on the untreated or TFE-treated surfaces, M1 and R2 binding was relatively high compared to background, while R1 binding was low. tetrafluoroethylene 44-47 fibrinogen beta chain Homo sapiens 4-14 7593010-9 1995 However, the amount of binding of each mAb to fibrinogen adsorbed on the TFE-treated surfaces was equal to or greater than fibrinogen adsorbed to the untreated surfaces. tetrafluoroethylene 73-76 fibrinogen beta chain Homo sapiens 46-56 7631311-8 1995 The results suggest a water exclusion effect, inducing cryoprecipitation of otherwise soluble fibrin/fibrinogen complexes. Water 22-27 fibrinogen beta chain Homo sapiens 101-111 7631313-7 1995 At ionic strength 0.15 and at different calcium concentrations analysis by permeability showed the same results for fibrinogen Tampere as for normal gels. Calcium 40-47 fibrinogen beta chain Homo sapiens 116-126 7631313-10 1995 In fibrin gels from fibrinogen Tampere, the gamma-chain crosslinking was normal but the crosslinking of alpha-chains was delayed at ionic strength 0.2 and also at lower ionic strengths on lowering the calcium concentration. Calcium 201-208 fibrinogen beta chain Homo sapiens 20-30 7752183-4 1995 Since the 400-411 sequence is required for gamma-chain bioactivity and is a unique recognition sequence among ligands for integrins, vis-a-vis other RGD (Arg-Gly-Asp)-presenting proteins, these turn mimetics may represent a new, selective approach to antagonism of the fibrinogen receptor. Arginine 154-157 fibrinogen beta chain Homo sapiens 269-279 7752183-4 1995 Since the 400-411 sequence is required for gamma-chain bioactivity and is a unique recognition sequence among ligands for integrins, vis-a-vis other RGD (Arg-Gly-Asp)-presenting proteins, these turn mimetics may represent a new, selective approach to antagonism of the fibrinogen receptor. Glycine 158-161 fibrinogen beta chain Homo sapiens 269-279 7752183-4 1995 Since the 400-411 sequence is required for gamma-chain bioactivity and is a unique recognition sequence among ligands for integrins, vis-a-vis other RGD (Arg-Gly-Asp)-presenting proteins, these turn mimetics may represent a new, selective approach to antagonism of the fibrinogen receptor. Aspartic Acid 162-165 fibrinogen beta chain Homo sapiens 269-279 7741112-4 1995 This study examines the capacity of anti-PlAl from patients with PTP and from mothers of infants affected by the NAIT to block the binding of radio-labeled fibrinogen to washed human platelets stimulated by ADP and epinephrine. Adenosine Diphosphate 207-210 fibrinogen beta chain Homo sapiens 156-166 7741112-4 1995 This study examines the capacity of anti-PlAl from patients with PTP and from mothers of infants affected by the NAIT to block the binding of radio-labeled fibrinogen to washed human platelets stimulated by ADP and epinephrine. Epinephrine 215-226 fibrinogen beta chain Homo sapiens 156-166 7544637-4 1995 Using synthetic peptides, they mimicked the new amino or carboxy terminal sequences of the A alpha-, B beta- and gamma-chains of Fbg that are generated by elastase. Peptides 16-24 fibrinogen beta chain Homo sapiens 129-132 8585011-1 1995 Fibrinogen labeled with fluorescein isothiocyanate (FITC) was tested for its ability to serve as a template for macromolecular assembly as well as to provide a fluorogenic signal to allow continuous monitoring of plasminogen activation and fibrinolysis. Fluorescein-5-isothiocyanate 24-50 fibrinogen beta chain Homo sapiens 0-10 8585011-1 1995 Fibrinogen labeled with fluorescein isothiocyanate (FITC) was tested for its ability to serve as a template for macromolecular assembly as well as to provide a fluorogenic signal to allow continuous monitoring of plasminogen activation and fibrinolysis. Fluorescein-5-isothiocyanate 52-56 fibrinogen beta chain Homo sapiens 0-10 8585011-2 1995 As dilute solutions of FITC-fibrinogen or FITC-fibrin fiber suspension were degraded during lysis, release of fluorescent fragments abolished proximity-based quenching and resulted in a 2.0- or 3.6-fold increase in fluorescence intensity, respectively. Fluorescein-5-isothiocyanate 23-27 fibrinogen beta chain Homo sapiens 28-38 8585011-3 1995 Addition of plasmin at a final concentration of 10 pM to FITC-fibrinogen (10 nM) produced a detectable level of fluorescence dequenching. Fluorescein-5-isothiocyanate 57-61 fibrinogen beta chain Homo sapiens 62-72 8585011-7 1995 Addition of thrombin (1 U/ml) and plasmin (0.1 nM) to 10 nM FITC-fibrinogen produced fluorescence quenching at first due to fibrinogen polymerization followed by dequenching due to fibrinolysis. Fluorescein-5-isothiocyanate 60-64 fibrinogen beta chain Homo sapiens 65-75 8585011-7 1995 Addition of thrombin (1 U/ml) and plasmin (0.1 nM) to 10 nM FITC-fibrinogen produced fluorescence quenching at first due to fibrinogen polymerization followed by dequenching due to fibrinolysis. Fluorescein-5-isothiocyanate 60-64 fibrinogen beta chain Homo sapiens 124-134 7669481-15 1995 The results of this study indicate that lisinopril reduces levels of plasma fibrinogen and confirm that different antihypertensive drugs may elicit different metabolic effects, which may variously influence the overall risk profile of the hypertensive patients. Lisinopril 40-50 fibrinogen beta chain Homo sapiens 76-86 7607582-2 1995 We compared the value of heparin-induced extracorporeal LDL precipitation (HELP) which is a method that safely and effectively reduces plasma fibrinogen and lipoproteins and so improves the hemorheologic pattern and blood flow properties. Heparin 25-32 fibrinogen beta chain Homo sapiens 142-152 7729904-4 1995 To validate this model, the oligosaccharide moieties of porcine fibrinogen were analyzed with glycosidases and by lectin blotting and sugar composition. Oligosaccharides 28-43 fibrinogen beta chain Homo sapiens 64-74 7729904-7 1995 O-glycans were also detected on B beta and gamma chains of porcine fibrinogen and contribute to the recognition of these chains by K88ac and K88ad fimbriae. o-glycans 0-9 fibrinogen beta chain Homo sapiens 67-77 7738488-6 1995 RESULTS: Free testosterone correlated inversely (P < 0.05) with weight, BMI, WHR, and fibrinogen, and positively with FEV1. Testosterone 14-26 fibrinogen beta chain Homo sapiens 89-99 7738493-9 1995 Serum sialic acid correlated strongly with plasma fibrinogen (r = 0.78; P < 0.0001) and erythrocyte sedimentation rate (r = 0.62; P < 0.0001). N-Acetylneuraminic Acid 6-17 fibrinogen beta chain Homo sapiens 50-60 7749766-6 1995 Fibrinogen was purified via glycine precipitation, and the sialic acid (SA) content was determined. Glycine 28-35 fibrinogen beta chain Homo sapiens 0-10 7654933-10 1995 It also suggests that the change Arg-->Cys produces more severe alterations in the functions of fibrinogen than the substitution Arg-->His. Arginine 33-36 fibrinogen beta chain Homo sapiens 96-106 7654933-10 1995 It also suggests that the change Arg-->Cys produces more severe alterations in the functions of fibrinogen than the substitution Arg-->His. Cysteine 39-42 fibrinogen beta chain Homo sapiens 96-106 7749766-6 1995 Fibrinogen was purified via glycine precipitation, and the sialic acid (SA) content was determined. N-Acetylneuraminic Acid 59-70 fibrinogen beta chain Homo sapiens 0-10 7749766-6 1995 Fibrinogen was purified via glycine precipitation, and the sialic acid (SA) content was determined. N-Acetylneuraminic Acid 72-74 fibrinogen beta chain Homo sapiens 0-10 7749766-12 1995 CONCLUSIONS: These data support the notion that an altered fibrinogen exists in some children with nephrotic syndrome characterized by an increased TT and RT, elevated fibrinogen, and both an increased negative charge and SA content. N-Acetylneuraminic Acid 222-224 fibrinogen beta chain Homo sapiens 59-69 7623433-10 1995 The combination of low Quick value and normal fibrinogen as well as platelet level is a good diagnostic indicator which can be confirmed by administration of vitamin K, after which the Quick value will rise within 30 minutes. Vitamin K 158-167 fibrinogen beta chain Homo sapiens 46-56 7750804-2 1995 In an earlier report, we found that fibrinogen is oxidized when whole plasma is treated with a metal-catalyzed oxidation system. Metals 95-100 fibrinogen beta chain Homo sapiens 36-46 7760665-2 1995 Fibrin tissue adhesive (FTA) and diode laser welding with indocyanine green-dyed fibrinogen were evaluated in tracheal anastomosis to reduce the number of sutures and to improve healing. Indocyanine Green 58-75 fibrinogen beta chain Homo sapiens 81-91 7482417-3 1995 The present study compared fibrinogen binding and platelet aggregation in response to dithiothreitol (DTT) and ADP. Dithiothreitol 86-100 fibrinogen beta chain Homo sapiens 27-37 7482417-3 1995 The present study compared fibrinogen binding and platelet aggregation in response to dithiothreitol (DTT) and ADP. Dithiothreitol 102-105 fibrinogen beta chain Homo sapiens 27-37 7482417-3 1995 The present study compared fibrinogen binding and platelet aggregation in response to dithiothreitol (DTT) and ADP. Adenosine Diphosphate 111-114 fibrinogen beta chain Homo sapiens 27-37 7482417-4 1995 DTT induced saturable and specific fibrinogen binding (Kd 0.07 + 0.02 microM, Bmax 15,000 + 3000 molecules/platelet) which supported complete platelet aggregation as determined by single platelet counting. Dithiothreitol 0-3 fibrinogen beta chain Homo sapiens 35-45 7482417-6 1995 Unlike fibrinogen bound to ADP-stimulated platelets, fibrinogen bound to DTT-treated platelets remained sensitive to dissociation by EDTA over a 3 h time course, retained its ability to support aggregation, even when aggregation was induced 60 min after the initial platelet exposure to fibrinogen, and remained accessible to polyclonal antibodies and plasmin. Dithiothreitol 73-76 fibrinogen beta chain Homo sapiens 53-63 7482417-6 1995 Unlike fibrinogen bound to ADP-stimulated platelets, fibrinogen bound to DTT-treated platelets remained sensitive to dissociation by EDTA over a 3 h time course, retained its ability to support aggregation, even when aggregation was induced 60 min after the initial platelet exposure to fibrinogen, and remained accessible to polyclonal antibodies and plasmin. Dithiothreitol 73-76 fibrinogen beta chain Homo sapiens 53-63 7482417-6 1995 Unlike fibrinogen bound to ADP-stimulated platelets, fibrinogen bound to DTT-treated platelets remained sensitive to dissociation by EDTA over a 3 h time course, retained its ability to support aggregation, even when aggregation was induced 60 min after the initial platelet exposure to fibrinogen, and remained accessible to polyclonal antibodies and plasmin. Edetic Acid 133-137 fibrinogen beta chain Homo sapiens 53-63 7482417-6 1995 Unlike fibrinogen bound to ADP-stimulated platelets, fibrinogen bound to DTT-treated platelets remained sensitive to dissociation by EDTA over a 3 h time course, retained its ability to support aggregation, even when aggregation was induced 60 min after the initial platelet exposure to fibrinogen, and remained accessible to polyclonal antibodies and plasmin. Edetic Acid 133-137 fibrinogen beta chain Homo sapiens 53-63 7482417-7 1995 Confocal scanning laser microscopy showed only a surface clustering of fibrinogen bound to DTT-treated platelets over the 3 h time course compared to rapid fibrinogen clearing from the surface of ADP-stimulated platelets. Dithiothreitol 91-94 fibrinogen beta chain Homo sapiens 71-81 7900741-8 1995 Fibrinogen was significantly correlated with collagen- and adenosine-diphosphate-induced platelet aggregation and with platelet adherence, spreading, and thrombus formation on subendothelium. Adenosine Diphosphate 59-80 fibrinogen beta chain Homo sapiens 0-10 7605873-0 1995 Effect of nifedipine on changes in fibrinogen and von Willebrand factor in haemodialysis patients treated with recombinant human erythropoietin. Nifedipine 10-20 fibrinogen beta chain Homo sapiens 35-45 7605873-3 1995 The effect of nifedipine, used to treat EPO therapy-related hypertension, on levels of fibrinogen and von Willebrand factor antigen (vWf) was studied in a group of 21 EPO-treated haemodialysis patients. Nifedipine 14-24 fibrinogen beta chain Homo sapiens 87-97 7622528-4 1995 In some experiments the test polymers were adsorbed with fibrinogen or IgG prior to the addition of monocytes. Polymers 29-37 fibrinogen beta chain Homo sapiens 57-67 7791577-6 1995 Resting fibrinogen concentrations (RFC) before conditioning were similar between the two groups, and demonstrated no change in the C group (242.9 +/- 40.3 mg.dl-1 vs 247.4 +/- 38.7 mg.dl-1, P > 0.05) after conditioning. Carbon 37-38 fibrinogen beta chain Homo sapiens 8-18 7629727-0 1995 Preparation and characterization of fibrinogen-coated, reversibly adhesive, lecithin/cholesterol vesicles. Lecithins 76-84 fibrinogen beta chain Homo sapiens 36-46 7629727-0 1995 Preparation and characterization of fibrinogen-coated, reversibly adhesive, lecithin/cholesterol vesicles. Cholesterol 85-96 fibrinogen beta chain Homo sapiens 36-46 7629727-1 1995 We have developed a method for producing fibrinogen-coated, reversibly adhesive, lecithin/cholesterol vesicles. Lecithins 81-89 fibrinogen beta chain Homo sapiens 41-51 7629727-1 1995 We have developed a method for producing fibrinogen-coated, reversibly adhesive, lecithin/cholesterol vesicles. Cholesterol 90-101 fibrinogen beta chain Homo sapiens 41-51 7495060-5 1995 Very low density lipoprotein (VLDL) triglyceride was a strong determinant of VIIag and PAI-1 activity levels in both cases and controls, whereas VLDL triglyceride in controls and LDL cholesterol in patients related significantly to the plasma fibrinogen concentration. Triglycerides 36-48 fibrinogen beta chain Homo sapiens 243-253 7617961-2 1995 The RGD tripeptide acts as an integrin recognition sequence; it is also present on several proteins involved in cell adhesion such as fibrinogen, fibronectin, von Willebrand factor, and collagen. tripeptide K-26 8-18 fibrinogen beta chain Homo sapiens 134-144 7617961-4 1995 Disintegrins are up to 2000 times more potent than short synthetic linear RGD-containing peptides in blocking fibrinogen-dependent platelet aggregation. Peptides 89-97 fibrinogen beta chain Homo sapiens 110-120 7495060-6 1995 Thus, our data suggests that plasma insulin and insulin propeptides might be involved in the regulation of plasma fibrinogen concentration, factor VII level and plasma PAI-1 activity. propeptides 56-67 fibrinogen beta chain Homo sapiens 114-124 7495075-0 1995 Calcium ion-dependent monoclonal antibody against human fibrinogen: preparation, characterization, and application to fibrinogen purification. Calcium 0-7 fibrinogen beta chain Homo sapiens 56-66 7495075-1 1995 We have produced a high-affinity monoclonal antibody classified as IgG1 with kappa-type light chains that recognizes the calcium ion(Ca2+)-dependent conformation of the D-domain of human fibrinogen. Calcium 121-128 fibrinogen beta chain Homo sapiens 187-197 7495075-0 1995 Calcium ion-dependent monoclonal antibody against human fibrinogen: preparation, characterization, and application to fibrinogen purification. Calcium 0-7 fibrinogen beta chain Homo sapiens 118-128 7703352-0 1995 Involvement of protein solvation in the interaction between a contrast medium (iopamidol) and fibrinogen or lysozyme. Iopamidol 79-88 fibrinogen beta chain Homo sapiens 94-104 7845427-8 1995 In patients with high serum cholesterol levels, the risk of coronary events rose with increasing levels of fibrinogen and C-reactive protein, but the risk remained low even given high serum cholesterol levels in the presence of low fibrinogen concentrations. Cholesterol 28-39 fibrinogen beta chain Homo sapiens 107-117 7845427-8 1995 In patients with high serum cholesterol levels, the risk of coronary events rose with increasing levels of fibrinogen and C-reactive protein, but the risk remained low even given high serum cholesterol levels in the presence of low fibrinogen concentrations. Cholesterol 28-39 fibrinogen beta chain Homo sapiens 232-242 7845427-10 1995 In addition, low fibrinogen concentrations characterize patients at low risk for coronary events despite increased serum cholesterol levels. Cholesterol 121-132 fibrinogen beta chain Homo sapiens 17-27 7740524-2 1995 Since denatured fibrinogen stimulates the t-PA-catalysed conversion of plasminogen to plasmin, it was of interest to study the sensitivity of t-PA-stimulation as evidence of fibrinogen denaturation. t-pa 42-46 fibrinogen beta chain Homo sapiens 16-26 7788039-15 1995 This beneficial effect of gemfibrozil, which was expressed by the third month and was evident for some time afterwards, was attributed to a significant reduction of triglyceride and fibrinogen levels, an increase of HDL cholesterol concentrations and a moderate decrease of total cholesterol and LDL cholesterol levels. Gemfibrozil 26-37 fibrinogen beta chain Homo sapiens 182-192 7796826-8 1995 Alcohol intake and oestrogen replacement therapy are associated with lower fibrinogen levels. Alcohols 0-7 fibrinogen beta chain Homo sapiens 75-85 7796831-7 1995 Among the oral fibrinogen-lowering drugs, fibrates rank first (e.g. bezafibrate has been reported to reduce increased fibrinogen by as much as 40%, and ticlopidine can induce a reduction of about 15% if fibrinogen was elevated at baseline). Ticlopidine 152-163 fibrinogen beta chain Homo sapiens 15-25 7796831-9 1995 Finally (and obviously), intravenous fibrinolytic agents or heparin-induced extracorporeal low-density lipoprotein precipitation will lower fibrinogen dramatically; yet these procedures are rarely indicated for this purpose alone. Heparin 60-67 fibrinogen beta chain Homo sapiens 140-150 7796833-1 1995 Fibrinogen is a large heterogeneous family of closely related molecules consisting of three pairs of non-identical polypeptide chains: two A alpha-, two B beta- and two gamma-chains, held together by disulphide bridges. disulphide 200-210 fibrinogen beta chain Homo sapiens 0-10 7789679-6 1995 In the initial period after injection of ethanol or thrombin, fibrinogen level and platelet count were significantly reduced. Ethanol 41-48 fibrinogen beta chain Homo sapiens 62-72 7615583-4 1995 Fibrinogen, albumin, IgG, high molecular weight kininogen (HMWK), and lipoproteins ApoA-1 and ApoE were the major proteins adsorbed onto polyarylamide. polyarylamide 137-150 fibrinogen beta chain Homo sapiens 0-10 7615583-6 1995 There was an inverse relationship between ApoA-1 and fibrinogen binding for all four biomaterials; polyarylamide bound a high percentage of fibrinogen, but little ApoA-1; polylactic acid, polyester, and polypropylene bound a high percentage of ApoA-1, but little fibrinogen. polyarylamide 99-112 fibrinogen beta chain Homo sapiens 140-150 7615583-6 1995 There was an inverse relationship between ApoA-1 and fibrinogen binding for all four biomaterials; polyarylamide bound a high percentage of fibrinogen, but little ApoA-1; polylactic acid, polyester, and polypropylene bound a high percentage of ApoA-1, but little fibrinogen. polyarylamide 99-112 fibrinogen beta chain Homo sapiens 140-150 7740524-2 1995 Since denatured fibrinogen stimulates the t-PA-catalysed conversion of plasminogen to plasmin, it was of interest to study the sensitivity of t-PA-stimulation as evidence of fibrinogen denaturation. t-pa 142-146 fibrinogen beta chain Homo sapiens 174-184 7740524-3 1995 Therefore, fibrinogen was intentionally exposed to various denaturating conditions (freeze-drying, heating, EDTA, alkali), and the clottability, the thrombin clotting time and the t-PA-stimulating effect were recorded. Edetic Acid 108-112 fibrinogen beta chain Homo sapiens 11-21 7740524-4 1995 We found that the clottability was a poor indicator of fibrinogen denaturation, whereas the t-PA-stimulating effect could detect even mild fibrinogen denaturation. t-pa 92-96 fibrinogen beta chain Homo sapiens 139-149 7740524-7 1995 In some instances therefore, the t-PA-stimulation is an even more sensitive and reliable indicator of fibrinogen denaturation than is the thrombin clotting time. t-pa 33-37 fibrinogen beta chain Homo sapiens 102-112 7833476-0 1995 Fibrinogen inhibits the heparin cofactor II-mediated antithrombin activity of dermatan sulfate. Dermatan Sulfate 78-94 fibrinogen beta chain Homo sapiens 0-10 7862675-3 1995 Antisera raised to synthetic peptides based on the cDNA sequence confirmed that the alpha" chain was present in fibrinogen prepared directly from plasma. Peptides 29-37 fibrinogen beta chain Homo sapiens 112-122 7836460-2 1995 Cell surface receptors called integrins mediate diverse cell adhesion phenomena through recognition of the sequence arginine-glycine-aspartic acid (RGD) present in proteins such as fibronectin and fibrinogen. arginyl-glycyl-aspartic acid 116-146 fibrinogen beta chain Homo sapiens 197-207 7742784-0 1995 The effects of pH on the generation of turbidity and elasticity associated with fibrinogen-fibrin conversion by thrombin are remarkably influenced by sialic acid in fibrinogen. N-Acetylneuraminic Acid 150-161 fibrinogen beta chain Homo sapiens 80-90 7742784-0 1995 The effects of pH on the generation of turbidity and elasticity associated with fibrinogen-fibrin conversion by thrombin are remarkably influenced by sialic acid in fibrinogen. N-Acetylneuraminic Acid 150-161 fibrinogen beta chain Homo sapiens 165-175 7742784-2 1995 Since sialic acids at the terminal of the carbohydrate chains bound to fibrinogen are part of the low affinity calcium binding site necessary for polymerization, they are closely involved in the network structure of fibrin clots. Sialic Acids 6-18 fibrinogen beta chain Homo sapiens 71-81 7742784-2 1995 Since sialic acids at the terminal of the carbohydrate chains bound to fibrinogen are part of the low affinity calcium binding site necessary for polymerization, they are closely involved in the network structure of fibrin clots. Carbohydrates 42-54 fibrinogen beta chain Homo sapiens 71-81 7742784-2 1995 Since sialic acids at the terminal of the carbohydrate chains bound to fibrinogen are part of the low affinity calcium binding site necessary for polymerization, they are closely involved in the network structure of fibrin clots. Calcium 111-118 fibrinogen beta chain Homo sapiens 71-81 7742784-6 1995 Concerning the elasticity evaluated by thromboelastography, the coagulation time (k) and the maximum amplitude (ma) were lower in asialofibrinogen, indicating a deterioration of the clotting function of fibrinogen with the loss of sialic acid. N-Acetylneuraminic Acid 231-242 fibrinogen beta chain Homo sapiens 136-146 7742784-7 1995 These results suggest that sialic acid bound to fibrinogen is closely related to the fibrin network formation in blood coagulation, which is the most important function of fibrinogen, and plays a functional role in the stabilization of fibrin clot formation against environmental changes, including pH. N-Acetylneuraminic Acid 27-38 fibrinogen beta chain Homo sapiens 48-58 7742784-7 1995 These results suggest that sialic acid bound to fibrinogen is closely related to the fibrin network formation in blood coagulation, which is the most important function of fibrinogen, and plays a functional role in the stabilization of fibrin clot formation against environmental changes, including pH. N-Acetylneuraminic Acid 27-38 fibrinogen beta chain Homo sapiens 172-182 7792747-3 1995 In this paper, we have measured fibrinogen binding in relation to phospholipase C (PLC) activation and calcium mobilization in TDP activates by ADP, epinephrine and U46619. Adenosine Diphosphate 144-147 fibrinogen beta chain Homo sapiens 32-42 7792747-3 1995 In this paper, we have measured fibrinogen binding in relation to phospholipase C (PLC) activation and calcium mobilization in TDP activates by ADP, epinephrine and U46619. Epinephrine 149-160 fibrinogen beta chain Homo sapiens 32-42 7792747-3 1995 In this paper, we have measured fibrinogen binding in relation to phospholipase C (PLC) activation and calcium mobilization in TDP activates by ADP, epinephrine and U46619. 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid 165-171 fibrinogen beta chain Homo sapiens 32-42 7792747-4 1995 ADP caused fibrinogen binding in TDP but neither activated PLC nor caused a calcium mobilization. Adenosine Diphosphate 0-3 fibrinogen beta chain Homo sapiens 11-21 7792747-5 1995 The requirement for ADP in inducing exposure of fibrinogen binding sites was not absolute since the combination of epinephrine and U46619 produced an increase in fibrinogen binding. Adenosine Diphosphate 20-23 fibrinogen beta chain Homo sapiens 48-58 7792747-5 1995 The requirement for ADP in inducing exposure of fibrinogen binding sites was not absolute since the combination of epinephrine and U46619 produced an increase in fibrinogen binding. Adenosine Diphosphate 20-23 fibrinogen beta chain Homo sapiens 162-172 7695204-6 1995 Our serial observation with treatment for lowering glucose levels showed that the diabetics with decreasing plasma fibrinogen levels also showed decrease in plasma IL-6 levels. Glucose 51-58 fibrinogen beta chain Homo sapiens 115-125 7837237-0 1995 Novel thiazole-based heterocycles as selective inhibitors of fibrinogen-mediated platelet aggregation. Thiazoles 6-14 fibrinogen beta chain Homo sapiens 61-71 7865240-5 1995 The study showed a decrease in blood and plasma viscosity during treatment with 5-FU, probably caused by a decrease of plasma fibrinogen. Fluorouracil 80-84 fibrinogen beta chain Homo sapiens 126-136 7585737-5 1995 ASL and ASA were positively associated with age, fasting blood sugar levels and plasma fibrinogen levels, and these associations were statistically significant. Aspirin 8-11 fibrinogen beta chain Homo sapiens 87-97 9363587-2 1995 Previously we reported that circulating immune complexes (CIC) inhibited fibrinogen binding to platelet glycoprotein IIb/IIIa complex (GPIIb/IIIa) and that isolated Fc gamma R were recognized by monoclonal antibodies (mAb"s) to GPIIb and GPIIIa (J.Lab. cic 58-61 fibrinogen beta chain Homo sapiens 73-83 8867673-5 1995 However, Mg2+, either alone or together with Ca2+, promoted stimulated adhesion to fibrinogen. magnesium ion 9-13 fibrinogen beta chain Homo sapiens 83-93 8867673-6 1995 We also found that Mn2+ promoted PMN adhesion to fibrinogen without additional stimuli. Manganese(2+) 19-23 fibrinogen beta chain Homo sapiens 49-59 8867673-14 1995 The evidence that Mn2+, a strong promoter of integrin function, induces adhesion and activation of tyrosine kinases without additional stimuli suggest the existence of a direct link between beta 2 integrins binding to fibrinogen and activation of tyrosine kinases in neutrophils. Manganese(2+) 18-22 fibrinogen beta chain Homo sapiens 218-228 8815283-1 1995 As shown by 125I-fibrinogen, in the course of 10-year investigation on low-dose heparin given in low doses (15000 U/day) to prevent postoperative thrombosis in the deep veins of the lower limbs, the investigators succeeded in the reduction of the thrombosis occurrence from 32 to 8%. Heparin 80-87 fibrinogen beta chain Homo sapiens 17-27 7531260-3 1995 In vivo ATRA therapy induces a rapid correction of both low fibrinogen level and bleeding tendency, but no clear explanation of this beneficial effect has been proposed. Tretinoin 8-12 fibrinogen beta chain Homo sapiens 60-70 7531260-8 1995 Moreover, was observed a rapid simultaneous correction of low fibrinogen levels and plasmin activation markers in APL patients undergoing ATRA therapy (before day 5), but a more prolonged persistence of DIC markers (until day 14). Tretinoin 138-142 fibrinogen beta chain Homo sapiens 62-72 7531260-11 1995 In vivo differentiation ATRA therapy induces a rapid decrease in the plasmin activation and a normalization of fibrinogen level, while DIC may in vivo persist for several weeks. Tretinoin 24-28 fibrinogen beta chain Homo sapiens 111-121 21043735-4 1995 There are now at least two systems of platelet activation under intensive study: (a) agonist (e.g. ADP and thrombin) induced platelet activation when fibrinogen is the ligand; this process occurs at low shear forces and is aspirin sensitive; (b) secondly, in marked contrast, at high shear forces, shear itself activates the platelets and von Willebrand"s factor (vWf) is the ligand, and this process is aspirin insensitive. Adenosine Diphosphate 99-102 fibrinogen beta chain Homo sapiens 150-160 21043735-4 1995 There are now at least two systems of platelet activation under intensive study: (a) agonist (e.g. ADP and thrombin) induced platelet activation when fibrinogen is the ligand; this process occurs at low shear forces and is aspirin sensitive; (b) secondly, in marked contrast, at high shear forces, shear itself activates the platelets and von Willebrand"s factor (vWf) is the ligand, and this process is aspirin insensitive. Aspirin 223-230 fibrinogen beta chain Homo sapiens 150-160 21043735-4 1995 There are now at least two systems of platelet activation under intensive study: (a) agonist (e.g. ADP and thrombin) induced platelet activation when fibrinogen is the ligand; this process occurs at low shear forces and is aspirin sensitive; (b) secondly, in marked contrast, at high shear forces, shear itself activates the platelets and von Willebrand"s factor (vWf) is the ligand, and this process is aspirin insensitive. Aspirin 404-411 fibrinogen beta chain Homo sapiens 150-160 7740487-15 1995 Mainly two mechanisms to explain thrombosis as a consequence of malfunctioning fibrinogen have been suggested: a) A defective binding of thrombin to abnormal fibrin which leads to increased thrombin levels (Malmo, Naples, New York I, Pamplona II, Poitiers), b) A defective stimulatory function of abnormal fibrin in the t-PA mediated fibrinolysis (Argenteuil, Chapel Hill III, Date, New York I, Nijmegen, Pamplona II, Paris V). t-pa 320-324 fibrinogen beta chain Homo sapiens 79-89 7716890-2 1995 In a group of patients with medium and severe cardiac failure the administration of sulodexide led to an increased activation of the fibrinolytic potential--a drop of PAI-1 and fibrinogen, to an increased activation of anticoagulatory potential--an increase of AT III and reduced plasma viscosity. glucuronyl glucosamine glycan sulfate 84-94 fibrinogen beta chain Homo sapiens 177-187 7529494-4 1994 Kistrin and dendroaspin exhibited similar inhibitory characteristics, abrogating platelet adhesion to fibrinogen and vWF at nanomolar concentrations, but poorly inhibiting adhesion to fibronectin. kistrin 0-7 fibrinogen beta chain Homo sapiens 102-112 7529494-11 1994 In contrast with the behaviour of these venom proteins, the adhesion of ADP-treated platelets to immobilized fibrinogen, fibronectin and vWF was inhibited non-selectively by a range of monoclonal antibodies with specificity for the alpha IIb beta 3 complex. Adenosine Diphosphate 72-75 fibrinogen beta chain Homo sapiens 109-119 7538018-3 1994 The same disintegrins together with eristostatin, bitistatin and barbourin were also very potent inhibitors of fibrinogen binding to alpha IIb beta 3 integrin. eristostatin 36-48 fibrinogen beta chain Homo sapiens 111-121 7538018-3 1994 The same disintegrins together with eristostatin, bitistatin and barbourin were also very potent inhibitors of fibrinogen binding to alpha IIb beta 3 integrin. bitistatin 50-60 fibrinogen beta chain Homo sapiens 111-121 7875035-0 1994 Fluorescein derivatization of fibrinogen for flow cytometric analysis of fibrinogen binding to platelets. Fluorescein 0-11 fibrinogen beta chain Homo sapiens 30-40 7875035-0 1994 Fluorescein derivatization of fibrinogen for flow cytometric analysis of fibrinogen binding to platelets. Fluorescein 0-11 fibrinogen beta chain Homo sapiens 73-83 7875035-1 1994 Dog and human fibrinogen were derivatized with N-hydroxysuccinimido-fluorescein and utilized for flow cytometric estimation of fibrinogen binding to activated platelets. n-hydroxysuccinimido-fluorescein 47-79 fibrinogen beta chain Homo sapiens 14-24 7875035-2 1994 Fluorescein-fibrinogen binding fulfilled the criteria for specific binding to platelets; the binding was saturable, dependent on agonist activation, and inhibited by unlabeled fibrinogen. Fluorescein 0-11 fibrinogen beta chain Homo sapiens 12-22 7875035-2 1994 Fluorescein-fibrinogen binding fulfilled the criteria for specific binding to platelets; the binding was saturable, dependent on agonist activation, and inhibited by unlabeled fibrinogen. Fluorescein 0-11 fibrinogen beta chain Homo sapiens 176-186 7875035-3 1994 In addition, EDTA and barbourin, a KGD-containing peptide, were found to inhibit the binding of fluorescein-fibrinogen. Edetic Acid 13-17 fibrinogen beta chain Homo sapiens 108-118 7875035-4 1994 Fluorescein-fibrinogen bound to dog platelets with an apparent affinity of 0.31 microM after stimulation with either adenosine-5"-diphosphate (ADP) or plateletactivating factor. Fluorescein 0-11 fibrinogen beta chain Homo sapiens 12-22 7875035-4 1994 Fluorescein-fibrinogen bound to dog platelets with an apparent affinity of 0.31 microM after stimulation with either adenosine-5"-diphosphate (ADP) or plateletactivating factor. Adenosine Diphosphate 117-141 fibrinogen beta chain Homo sapiens 12-22 7875035-4 1994 Fluorescein-fibrinogen bound to dog platelets with an apparent affinity of 0.31 microM after stimulation with either adenosine-5"-diphosphate (ADP) or plateletactivating factor. Adenosine Diphosphate 143-146 fibrinogen beta chain Homo sapiens 12-22 7875035-6 1994 Aged platelets were indistinguishable from young platelets with regard to fibrinogen binding in response to ADP. Adenosine Diphosphate 108-111 fibrinogen beta chain Homo sapiens 74-84 7875035-7 1994 These studies document that direct derivatization of fibrinogen with fluorescein generates a useful probe for analyzing fibrinogen binding to platelets with flow cytometry. Fluorescein 69-80 fibrinogen beta chain Homo sapiens 53-63 7875035-7 1994 These studies document that direct derivatization of fibrinogen with fluorescein generates a useful probe for analyzing fibrinogen binding to platelets with flow cytometry. Fluorescein 69-80 fibrinogen beta chain Homo sapiens 120-130 7601270-3 1994 Pigeon fibrinogen, isolated from plasma by precipitation with PEG-1000 and purified over Sepharose 4B, was used to study receptor-ligand interaction. polyethylene glycol 1000 62-70 fibrinogen beta chain Homo sapiens 7-17 7601270-3 1994 Pigeon fibrinogen, isolated from plasma by precipitation with PEG-1000 and purified over Sepharose 4B, was used to study receptor-ligand interaction. Sepharose 89-98 fibrinogen beta chain Homo sapiens 7-17 7601270-4 1994 Separation of pigeon fibrinogen on SDS-PAGE resulted in three peptides of molecular mass 62, 55, and 47 kDa, which were comparable to those of human fibrinogen. Sodium Dodecyl Sulfate 35-38 fibrinogen beta chain Homo sapiens 21-31 7881702-6 1994 Both treatments resulted in a statistically significant increase in TcPO2 and decrease in plasma fibrinogen but under calcium-heparin treatment these modifications were doubled in comparison with ASA (p < 0.01 and p < 0.05, respectively for TcPO2 and fibrinogen). calcium heparin 118-133 fibrinogen beta chain Homo sapiens 257-267 7621318-6 1994 Patients with a total-cholesterol level in excess of 220 mg/dl had significantly higher fibrinogen levels, and both univariate and multivariate analyses showed total-cholesterol and fibrinogen levels to be positively correlated. Cholesterol 22-33 fibrinogen beta chain Homo sapiens 88-98 7621318-6 1994 Patients with a total-cholesterol level in excess of 220 mg/dl had significantly higher fibrinogen levels, and both univariate and multivariate analyses showed total-cholesterol and fibrinogen levels to be positively correlated. Cholesterol 22-33 fibrinogen beta chain Homo sapiens 182-192 7621318-7 1994 A weaker but significant relationship was noted between the fibrinogen level and triglyceride levels (P = 0.0017) and between the fibrinogen level and the ratio of total-cholesterol to HDL-cholesterol levels (P = 0.0006). Triglycerides 81-93 fibrinogen beta chain Homo sapiens 60-70 7621318-7 1994 A weaker but significant relationship was noted between the fibrinogen level and triglyceride levels (P = 0.0017) and between the fibrinogen level and the ratio of total-cholesterol to HDL-cholesterol levels (P = 0.0006). Cholesterol 170-181 fibrinogen beta chain Homo sapiens 130-140 7621318-7 1994 A weaker but significant relationship was noted between the fibrinogen level and triglyceride levels (P = 0.0017) and between the fibrinogen level and the ratio of total-cholesterol to HDL-cholesterol levels (P = 0.0006). Cholesterol 189-200 fibrinogen beta chain Homo sapiens 130-140 7738068-2 1995 Increasing the molecular weight of PEG in the matrix from 1000 to 100,000 g/mol reduced the advancing and receding contact angles, contact angle hysteresis, and adsorption of human fibrinogen and bovine serum albumin. Polyethylene Glycols 35-38 fibrinogen beta chain Homo sapiens 181-191 7531212-8 1995 We found that 10 nmol/L SK and 14 nmol/L rt-PA increased fibrinogen binding to platelets by 12 +/- 2 and 10 +/- 4 times, respectively (p = not significant). rt-pa 41-46 fibrinogen beta chain Homo sapiens 57-67 7531212-12 1995 Conversely, rt-PA, at concentrations up to 14 nmol/L, only promotes fibrinogen binding. rt-pa 12-17 fibrinogen beta chain Homo sapiens 68-78 7837275-9 1995 Moreover, the values of delta Cp for alpha-, zeta- and gamma T-thrombin interaction with p-ABZ were found to be linearly correlated to the free energy of activation for both fibrinogen and CPR cleavage. 4-aminobenzamidine 89-94 fibrinogen beta chain Homo sapiens 174-184 7710120-1 1995 We present a kinetic assay based on the use of fluorescein isothiocyanate (FITC)-labeled fibrinogen as a fluoroactive substrate. Fluorescein-5-isothiocyanate 47-73 fibrinogen beta chain Homo sapiens 89-99 7710120-1 1995 We present a kinetic assay based on the use of fluorescein isothiocyanate (FITC)-labeled fibrinogen as a fluoroactive substrate. Fluorescein-5-isothiocyanate 75-79 fibrinogen beta chain Homo sapiens 89-99 7710120-2 1995 The multiple FITCs bound to fibrinogen experienced quenching due to their close proximity. Fluorescein-5-isothiocyanate 13-18 fibrinogen beta chain Homo sapiens 28-38 7710120-3 1995 The thrombin-induced polymerization of FITC-fibrinogen led to additional fluorescence quenching due to enhanced neighbor-neighbor interactions in protofibrils and protofibril aggregates. Fluorescein-5-isothiocyanate 39-43 fibrinogen beta chain Homo sapiens 44-54 7710120-7 1995 In contrast to polymerization, cleavage of fibrinogen by plasmin released FITC-labeled fragments free of proximity-based quenching that resulted in a large intensity increase as lysis proceeded--a process termed dequenching. Fluorescein-5-isothiocyanate 74-78 fibrinogen beta chain Homo sapiens 43-53 7710120-10 1995 Addition of epsilon-aminocaproic acid (epsilon ACA)-plasmin complex to FITC-fibrinogen produced little dequenching, demonstrating a requirement for binding in order to initiate lysis. Aminocaproic Acid 12-37 fibrinogen beta chain Homo sapiens 76-86 7710120-10 1995 Addition of epsilon-aminocaproic acid (epsilon ACA)-plasmin complex to FITC-fibrinogen produced little dequenching, demonstrating a requirement for binding in order to initiate lysis. Fluorescein-5-isothiocyanate 71-75 fibrinogen beta chain Homo sapiens 76-86 7813328-11 1995 Heparin presents an aspecific "nonfunctional" binding to plasma proteins such as fibrinogen, factor VIII, vitronectin, and fibronectin. Heparin 0-7 fibrinogen beta chain Homo sapiens 81-91 7758061-7 1995 The ability of niceritrol to decrease Lp(a) levels and increase HDL-C levels, together with its tendency to lower fibrinogen levels, may help prevent coronary events in patients with high levels of Lp(a). Niceritrol 15-25 fibrinogen beta chain Homo sapiens 114-124 8562519-3 1995 About 40% of adsorbed HSA and 80% of adsorbed HDL from the corresponding single protein solutions were desorbed by Tween 20 from polyethylene, whereas Tween 20 had a small effect on the desorption of adsorbed Fb and IgG under the same conditions. Polysorbates 151-159 fibrinogen beta chain Homo sapiens 209-211 8562519-4 1995 However, the desorption of Fb and IgG by Tween 20 was much higher in the case of a diluted plasma solution compared to a pure protein solution. Polysorbates 41-49 fibrinogen beta chain Homo sapiens 27-29 8608089-3 1995 Investigation of the protein adsorption of these polymer surfaces showed that copolymers with higher DMAA content adsorbed more albumin than fibrinogen. Polymers 49-56 fibrinogen beta chain Homo sapiens 141-151 7833476-4 1995 Analysis of the protein profile bound to immobilized dermatan sulphate showed that on a molar basis, histidine-rich glycoprotein and apolipoprotein E were the most abundant proteins specifically bound, together with significant amounts of fibrinogen and vitronectin. Dermatan Sulfate 53-70 fibrinogen beta chain Homo sapiens 239-249 7833476-5 1995 Addition of these proteins to the purified system showed that only fibrinogen inhibited the antithrombin activity of dermatan sulfate and that it did so in a concentration-dependent manner over the physiologic range of plasma fibrinogen levels. Dermatan Sulfate 117-133 fibrinogen beta chain Homo sapiens 67-77 7833476-6 1995 These results indicate that the anticoagulant activity of dermatan sulfate may be modulated in human plasma by fibrinogen. Dermatan Sulfate 58-74 fibrinogen beta chain Homo sapiens 111-121 7740463-5 1994 Mg2+ (4 mM) prolonged in vitro BT by 30% and inhibited Fg-mediated aggregation significantly, independent of the agonist used to initiate platelet aggregation (ADP, collagen, epinephrine, thrombin, phorbol ester). magnesium ion 0-4 fibrinogen beta chain Homo sapiens 55-57 7537915-7 1994 These data indicate that the bivalent binding of 7H2 to GPIIIa is required for its partial inhibition of fibrinogen binding to platelets, perhaps through dimerization of GPIIb/IIIa surface receptors (or more complex GPIIb/IIIa redistribution triggered by 7H2 binding) resulting in limited accessibility of fibrinogen to its binding site(s). 7H2 49-52 fibrinogen beta chain Homo sapiens 105-115 7537915-7 1994 These data indicate that the bivalent binding of 7H2 to GPIIIa is required for its partial inhibition of fibrinogen binding to platelets, perhaps through dimerization of GPIIb/IIIa surface receptors (or more complex GPIIb/IIIa redistribution triggered by 7H2 binding) resulting in limited accessibility of fibrinogen to its binding site(s). 7H2 49-52 fibrinogen beta chain Homo sapiens 306-316 7740463-6 1994 Adhesion of resting platelets to immobilised Fg was reduced by 50% in the presence of 2 mM Mg2+. magnesium ion 91-95 fibrinogen beta chain Homo sapiens 45-47 7740463-7 1994 Moreover, Mg2+ reduced Fg binding to ADP- or collagen-stimulated platelets as well as surface expression of GMP-140 with an IC50 of approximately 3 mM. magnesium ion 10-14 fibrinogen beta chain Homo sapiens 23-25 7740463-7 1994 Moreover, Mg2+ reduced Fg binding to ADP- or collagen-stimulated platelets as well as surface expression of GMP-140 with an IC50 of approximately 3 mM. Adenosine Diphosphate 37-40 fibrinogen beta chain Homo sapiens 23-25 7740463-8 1994 Intravenous administration of Mg2+ to healthy volunteers inhibited both ADP-induced platelet aggregation (p < 0.05) by 40% and binding of Fg or surface expression of GMP-140 by 30% (p < 0.05). magnesium ion 30-34 fibrinogen beta chain Homo sapiens 141-143 7961845-7 1994 Furthermore, fibrinogen binding to alpha IIb beta 3 stimulated directly with an anti-beta 3 antibody activated pp72syk 3-fold and stimulated its tyrosine phosphorylation. Tyrosine 145-153 fibrinogen beta chain Homo sapiens 13-23 7719106-5 1994 TXB2, 6-keto-PGF1 alpha, fibrinogen and plasmin activity as well as hemorheological indices are important pathophysiological manifestation of QDBS. qdbs 142-146 fibrinogen beta chain Homo sapiens 25-35 7871494-4 1994 Both APC (300-3000 U/kg) and heparin (100-300 IU/kg) inhibited the decreases in platelet count and fibrinogen level equally. Heparin 29-36 fibrinogen beta chain Homo sapiens 99-109 7695840-4 1994 Retinoic acid increased the effect of IL-6 on alpha-1-antichymotrypsin (ACT) and fibrinogen (FBG) on the level of both proteins and mRNAs. Tretinoin 0-13 fibrinogen beta chain Homo sapiens 81-91 7957919-1 1994 A monoclonal antibody, AC7, directed against the RGD (Arg-Gly-Asp) binding site on the GpIIIa subunit of the platelet fibrinogen receptor, interacts only with activated platelet. arginyl-glycyl-aspartic acid 54-65 fibrinogen beta chain Homo sapiens 118-128 7526817-7 1994 The correlation of citrate and EDTA fibrinogen values (fibrometer) was r = .9718; for citrate and special anticoagulant plasma, r = .9717. Citric Acid 19-26 fibrinogen beta chain Homo sapiens 36-46 7526817-7 1994 The correlation of citrate and EDTA fibrinogen values (fibrometer) was r = .9718; for citrate and special anticoagulant plasma, r = .9717. Edetic Acid 31-35 fibrinogen beta chain Homo sapiens 36-46 7526817-9 1994 We conclude that (1) fibrinogen may be measured by clot-rate assay in EDTA-containing samples and that values may be compared with values obtained from citrate plasma with a correction; (2) samples containing PPACK may be used with only slight modification of the method; and (3) values obtained on the analyzer are directly comparable with those obtained on the fibrometer, facilitating large studies. Edetic Acid 70-74 fibrinogen beta chain Homo sapiens 21-31 7695840-4 1994 Retinoic acid increased the effect of IL-6 on alpha-1-antichymotrypsin (ACT) and fibrinogen (FBG) on the level of both proteins and mRNAs. Tretinoin 0-13 fibrinogen beta chain Homo sapiens 93-96 7894222-6 1994 In group I four patients revealed positive 125I-labeled fibrinogen uptake (3.9%); two patients belonged to the hydroxyethyl starch subgroup. Iodine-125 43-47 fibrinogen beta chain Homo sapiens 56-66 7858144-6 1994 The number of fibrinogen receptors and bound Fg were measured from mean fluorescence values obtained with FITC-labeled IgM monoclonal antibody PAC1 and the IgG monoclonal antibody, 9F9, respectively, using flow cytometry as presented in part I (Frojmovic et al., 1994). Fluorescein-5-isothiocyanate 106-110 fibrinogen beta chain Homo sapiens 14-24 7533066-16 1994 These findings suggest that platelet fibrinogen binding and the release of platelet alpha-granule and lysosomal contents, in response to stimulation with physiological agonists, can continue in patients despite aspirin therapy. Aspirin 211-218 fibrinogen beta chain Homo sapiens 37-47 7857385-8 1994 In conclusion, micronised fenofibrate at a daily dose of 200 mg had significant lipid-modifying properties but also exhibited a beneficial effect on other related risk factors such as fibrinogen reduction. Fenofibrate 26-37 fibrinogen beta chain Homo sapiens 184-194 8924422-1 1995 The adhesive proteins fibrinogen (FG) and fibronectin (FN) were immobilized to glycine-Sephadex G-10. Glycine 79-86 fibrinogen beta chain Homo sapiens 22-32 8924422-1 1995 The adhesive proteins fibrinogen (FG) and fibronectin (FN) were immobilized to glycine-Sephadex G-10. sephadex 87-100 fibrinogen beta chain Homo sapiens 22-32 8924422-1 1995 The adhesive proteins fibrinogen (FG) and fibronectin (FN) were immobilized to glycine-Sephadex G-10. sephadex 87-100 fibrinogen beta chain Homo sapiens 34-36 7523416-7 1994 Pretreatment of normal platelets with 5 mM EDTA (37 degrees C for 90 min) or RGDS (2 mM), which disrupts the binding of various adhesive proteins to platelet integrins and inhibits fibrinogen-mediated platelet aggregation, did not alter the vWF-stimulated activation and cytoskeletal association of PtdIns 3-kinase and pp60c-src. Edetic Acid 43-47 fibrinogen beta chain Homo sapiens 181-191 7932809-12 1994 CONCLUSION: Favorable changes in lipid, lipoprotein, and fibrinogen levels seen early in tamoxifen therapy in postmenopausal women persist with treatment of 5 years. Tamoxifen 89-98 fibrinogen beta chain Homo sapiens 57-67 7524499-2 1994 Tetrafibricin, which inhibited fibrinogen-GPIIb/IIIa binding 10 times more potently than RGDS, was three orders of magnitude less potent compared to RGDS on the inhibition of fibrinogen binding to alpha v beta 3. tetrafibricin 0-13 fibrinogen beta chain Homo sapiens 31-41 7524499-2 1994 Tetrafibricin, which inhibited fibrinogen-GPIIb/IIIa binding 10 times more potently than RGDS, was three orders of magnitude less potent compared to RGDS on the inhibition of fibrinogen binding to alpha v beta 3. tetrafibricin 0-13 fibrinogen beta chain Homo sapiens 175-185 7524499-3 1994 Furthermore, tetrafibricin potently inhibited platelet adhesion to both fibrinogen and von Willebrand factor. tetrafibricin 13-26 fibrinogen beta chain Homo sapiens 72-82 7843797-1 1994 Physiological levels of human fibrinogen markedly inhibited the chemotactic activity of human neutrophils triggered by zymosan-activated serum (ZAS), C5a, or IL-8 in a Boyden chamber assay. Zymosan 119-126 fibrinogen beta chain Homo sapiens 30-40 7865680-7 1994 Platelets in plasma treated with prostaglandin E1 (resting platelets) adhered only to forms of fibrinogen which contained two gamma-chain platelet binding sites. Alprostadil 33-49 fibrinogen beta chain Homo sapiens 95-105 7865680-8 1994 These observations also demonstrate that the fibrinogen alpha-chain arginine-glycine-aspartic acid-phenylalanine and arginine-glycine-aspartic acid-serine sequences are not necessary or sufficient to mediate the adhesion of resting or stimulated platelets in plasma to fibrinogen. Arginine 68-76 fibrinogen beta chain Homo sapiens 45-55 7865680-8 1994 These observations also demonstrate that the fibrinogen alpha-chain arginine-glycine-aspartic acid-phenylalanine and arginine-glycine-aspartic acid-serine sequences are not necessary or sufficient to mediate the adhesion of resting or stimulated platelets in plasma to fibrinogen. Aspartic Acid 85-98 fibrinogen beta chain Homo sapiens 45-55 7865680-9 1994 The presence of endogenous adenosine diphosphate appears to account, at least in part, for the ability of normal platelets in plasma to adhere to forms of fibrinogen which have only one gamma-chain platelet binding site. Adenosine Diphosphate 27-48 fibrinogen beta chain Homo sapiens 155-165 7865683-0 1994 Fibrinogen present in EDTA--anticoagulated plasma stimulates the tissue-type plasminogen activator-catalysed conversion of plasminogen to plasmin. Edetic Acid 22-26 fibrinogen beta chain Homo sapiens 0-10 7865683-3 1994 It was previously shown that treatment of purified fibrinogen by EDTA, which removes the three tightly bound Ca2+ ions, results in exposure of tissue-type plasminogen activator-catalytic sites similar to those unveiled by thrombin. Edetic Acid 65-69 fibrinogen beta chain Homo sapiens 51-61 7865683-7 1994 The most probable explanation is that tissue-type plasminogen activator-stimulating sites are exposed in fibrinogen by EDTA. Edetic Acid 119-123 fibrinogen beta chain Homo sapiens 105-115 7851939-7 1994 The collective results suggested that the enzyme from monkey cerebellum was a casein kinase II-like protein kinase and that phosphorylation of a glycoprotein substrate (fibrinogen) by the kinase could be influenced by a carbohydrate binding lectin. Carbohydrates 220-232 fibrinogen beta chain Homo sapiens 169-179 7843797-1 1994 Physiological levels of human fibrinogen markedly inhibited the chemotactic activity of human neutrophils triggered by zymosan-activated serum (ZAS), C5a, or IL-8 in a Boyden chamber assay. ZAS 144-147 fibrinogen beta chain Homo sapiens 30-40 7843797-2 1994 Fibrinogen also slightly inhibited the N-formyl-methionyl leucyl-phenylalanine (FMLP)-induced migration of human neutrophils. N-Formylmethionine Leucyl-Phenylalanine 80-84 fibrinogen beta chain Homo sapiens 0-10 7843797-6 1994 Lysine as well as the lysine analog 6-aminohexanoic acid (AHA) decreased the inhibitory capacity of fibrinogen. Lysine 0-6 fibrinogen beta chain Homo sapiens 100-110 7843797-6 1994 Lysine as well as the lysine analog 6-aminohexanoic acid (AHA) decreased the inhibitory capacity of fibrinogen. Lysine 22-28 fibrinogen beta chain Homo sapiens 100-110 7843797-6 1994 Lysine as well as the lysine analog 6-aminohexanoic acid (AHA) decreased the inhibitory capacity of fibrinogen. Aminocaproic Acid 36-56 fibrinogen beta chain Homo sapiens 100-110 7843797-6 1994 Lysine as well as the lysine analog 6-aminohexanoic acid (AHA) decreased the inhibitory capacity of fibrinogen. Aminocaproic Acid 58-61 fibrinogen beta chain Homo sapiens 100-110 7843797-9 1994 Fibrinogen also inhibited, in a dose-dependent manner, the oxygen consumption of neutrophils activated by opsonized zymosan. Oxygen 59-65 fibrinogen beta chain Homo sapiens 0-10 7843797-9 1994 Fibrinogen also inhibited, in a dose-dependent manner, the oxygen consumption of neutrophils activated by opsonized zymosan. Zymosan 116-123 fibrinogen beta chain Homo sapiens 0-10 7829542-5 1994 After 5 days of residence time in buffer, the adsorbed fibrinogen was eluted with a 1% solution of the surfactant sodium dodecyl sulfate (SDS). Sodium Dodecyl Sulfate 114-136 fibrinogen beta chain Homo sapiens 55-65 7829542-5 1994 After 5 days of residence time in buffer, the adsorbed fibrinogen was eluted with a 1% solution of the surfactant sodium dodecyl sulfate (SDS). Sodium Dodecyl Sulfate 138-141 fibrinogen beta chain Homo sapiens 55-65 7829547-5 1994 This work deals with the behavior of fibrinogen adsorbed to PMMA alone, where the experimental variable was incubation time with the substrate, and with adsorbed fibrinogen mixed with albumin, where the experimental variable was the molar percent of fibrinogen in the adsorption solution. Polymethyl Methacrylate 60-64 fibrinogen beta chain Homo sapiens 37-47 7850250-1 1994 A semi-micro method (BR BLUE) is presented using Coomassie Brilliant Blue G-250 color reagent for the determination of fibrinogen on potentially turbid specimens. coomassie Brilliant Blue 49-79 fibrinogen beta chain Homo sapiens 119-129 7878632-6 1994 This study raises the question whether a particular fatty acid or group of fatty acids, or another constituent of the oil such as vitamin E may be responsible for the fibrinogen lowering effect. Vitamin E 130-139 fibrinogen beta chain Homo sapiens 167-177 25147429-9 1994 The influence of the surface density of the grafted PEG chains on protein repellence was tested by the adsorption of fibrinogen from solution and from a ternary protein solution mixture containing fibrinogen, albumin and immunoglobulin G. Fibrinogen adsorption onto the silica end of the gradient was extremely low, both in the presence of the other two proteins and in their absence. Polyethylene Glycols 52-55 fibrinogen beta chain Homo sapiens 117-127 8091447-0 1994 Effect of plasma fibrinogen concentration on the inhibition of platelet aggregation after ticlopidine compared with aspirin. Ticlopidine 90-101 fibrinogen beta chain Homo sapiens 17-27 8091447-2 1994 Because fibrinogen plays a central role in platelet aggregation and binding of fibrinogen to platelets is inhibited by ticlopidine, we studied the effect of the plasma fibrinogen concentration on the antiaggregatory action of ticlopidine compared with that of aspirin. Ticlopidine 119-130 fibrinogen beta chain Homo sapiens 79-89 8091447-2 1994 Because fibrinogen plays a central role in platelet aggregation and binding of fibrinogen to platelets is inhibited by ticlopidine, we studied the effect of the plasma fibrinogen concentration on the antiaggregatory action of ticlopidine compared with that of aspirin. Ticlopidine 119-130 fibrinogen beta chain Homo sapiens 79-89 8091447-3 1994 METHODS: We determined platelet aggregability before and after administration of ticlopidine (200 mg/d) or aspirin (81 mg/d) in 61 stroke patients and correlated the changes with the plasma fibrinogen concentration. Ticlopidine 81-92 fibrinogen beta chain Homo sapiens 190-200 8091447-4 1994 RESULTS: In patients receiving ticlopidine, the platelet aggregability induced by 1, 5, and 10 mumol/L adenosine diphosphate significantly decreased compared with aggregability before medication (P < .05), and the reductions had significant negative correlations with the plasma fibrinogen concentration (P < .05). Ticlopidine 31-42 fibrinogen beta chain Homo sapiens 282-292 8091447-5 1994 In patients receiving aspirin, the platelet aggregability induced by 2 micrograms/mL collagen and 5 and 10 mumol/L adenosine diphosphate decreased compared with aggregability before medication (P < .005), but the reductions had no significant correlation with the plasma fibrinogen concentration. Aspirin 22-29 fibrinogen beta chain Homo sapiens 274-284 8091447-6 1994 CONCLUSIONS: The relative antiaggregatory effect of ticlopidine is significantly decreased with higher plasma fibrinogen concentrations. Ticlopidine 52-63 fibrinogen beta chain Homo sapiens 110-120 25147429-10 1994 As the surface density of the grafted PEG chains increased, so did the fibrinogen adsorption (up to 0.024 mug cm-2). Polyethylene Glycols 38-41 fibrinogen beta chain Homo sapiens 71-81 8092274-5 1994 Interaction of nonstimulated platelets with solid-phase fibrinogen was also reduced by 8-azido-ATP and ATP. 8-azidoadenosine 5'-triphosphate 87-98 fibrinogen beta chain Homo sapiens 56-66 7523118-12 1994 Such inhibition of fibrinogen binding was sufficient to block aggregation of ADP-stimulated platelets by the anti-[GPIIIa(90-102)] antibodies in platelet-rich plasma. Adenosine Diphosphate 77-80 fibrinogen beta chain Homo sapiens 19-29 7831682-0 1994 Nitric oxide donors inhibit platelet spreading on surfaces coated with fibrinogen but not with fibronectin. Nitric Oxide 0-12 fibrinogen beta chain Homo sapiens 71-81 7831682-1 1994 We have studied the effect of nitric oxide (NO) on the interaction of washed human platelets with fibrinogen or fibronectin adsorbed on glass. Nitric Oxide 30-42 fibrinogen beta chain Homo sapiens 98-108 7831682-4 1994 On fibrinogen spreading was inhibited by NO donors in the order of potency: S-nitroso-acetylpenicillamine > sodium nitroprusside > S-nitroso-glutathione. S-Nitroso-N-Acetylpenicillamine 76-105 fibrinogen beta chain Homo sapiens 3-13 7831682-4 1994 On fibrinogen spreading was inhibited by NO donors in the order of potency: S-nitroso-acetylpenicillamine > sodium nitroprusside > S-nitroso-glutathione. Nitroprusside 111-131 fibrinogen beta chain Homo sapiens 3-13 7831682-4 1994 On fibrinogen spreading was inhibited by NO donors in the order of potency: S-nitroso-acetylpenicillamine > sodium nitroprusside > S-nitroso-glutathione. S-Nitrosoglutathione 137-158 fibrinogen beta chain Homo sapiens 3-13 8092274-0 1994 Effects of ATP on ligand recognition of platelet fibrinogen receptor on GPIIb-IIIa. Adenosine Triphosphate 11-14 fibrinogen beta chain Homo sapiens 49-59 8092274-1 1994 The recent discovery of 8-azido-ATP binding sites on the platelet fibrinogen receptor glycoprotein complex GPIIb-IIIa suggests that extracellular ATP may directly modulate function of GPIIb-IIIa. 8-azidoadenosine 5'-triphosphate 24-35 fibrinogen beta chain Homo sapiens 66-76 8092274-1 1994 The recent discovery of 8-azido-ATP binding sites on the platelet fibrinogen receptor glycoprotein complex GPIIb-IIIa suggests that extracellular ATP may directly modulate function of GPIIb-IIIa. Adenosine Triphosphate 32-35 fibrinogen beta chain Homo sapiens 66-76 8092274-3 1994 Fibrinogen-mediated aggregation of washed platelets was inhibited by ATP and 8-azido-ATP in a dose-dependent manner, independent of the agonist (thrombin, collagen, epinephrine, phorbol 12-myristate 13-acetate) used to induce platelet activation. Adenosine Triphosphate 69-72 fibrinogen beta chain Homo sapiens 0-10 8092274-3 1994 Fibrinogen-mediated aggregation of washed platelets was inhibited by ATP and 8-azido-ATP in a dose-dependent manner, independent of the agonist (thrombin, collagen, epinephrine, phorbol 12-myristate 13-acetate) used to induce platelet activation. 8-azidoadenosine 5'-triphosphate 77-88 fibrinogen beta chain Homo sapiens 0-10 8092274-3 1994 Fibrinogen-mediated aggregation of washed platelets was inhibited by ATP and 8-azido-ATP in a dose-dependent manner, independent of the agonist (thrombin, collagen, epinephrine, phorbol 12-myristate 13-acetate) used to induce platelet activation. Tetradecanoylphorbol Acetate 178-209 fibrinogen beta chain Homo sapiens 0-10 8092274-4 1994 In addition, 8-azido-ATP and ATP inhibited binding of 125I-labeled fibrinogen to thrombin- and phorbol ester-activated platelets. 8-azidoadenosine 5'-triphosphate 13-24 fibrinogen beta chain Homo sapiens 67-77 8092274-4 1994 In addition, 8-azido-ATP and ATP inhibited binding of 125I-labeled fibrinogen to thrombin- and phorbol ester-activated platelets. Adenosine Triphosphate 21-24 fibrinogen beta chain Homo sapiens 67-77 8092274-4 1994 In addition, 8-azido-ATP and ATP inhibited binding of 125I-labeled fibrinogen to thrombin- and phorbol ester-activated platelets. Iodine-125 54-58 fibrinogen beta chain Homo sapiens 67-77 8092274-4 1994 In addition, 8-azido-ATP and ATP inhibited binding of 125I-labeled fibrinogen to thrombin- and phorbol ester-activated platelets. Phorbol Esters 95-108 fibrinogen beta chain Homo sapiens 67-77 8082347-16 1994 After initiation of therapy, patients who had received bolus rt-PA had less depression of fibrinogen levels (p = 0.007) and smaller increases in fibrinogen degradation products (p = 0.013) than patients who had received 100 mg of rt-PA over 2 h. CONCLUSIONS: No significant differences were detected between the bolus rt-PA and 2-h rt-PA with respect to bleeding complications, adverse clinical events, or imaging studies. rt-pa 61-66 fibrinogen beta chain Homo sapiens 90-100 8082347-16 1994 After initiation of therapy, patients who had received bolus rt-PA had less depression of fibrinogen levels (p = 0.007) and smaller increases in fibrinogen degradation products (p = 0.013) than patients who had received 100 mg of rt-PA over 2 h. CONCLUSIONS: No significant differences were detected between the bolus rt-PA and 2-h rt-PA with respect to bleeding complications, adverse clinical events, or imaging studies. rt-pa 61-66 fibrinogen beta chain Homo sapiens 145-155 7814434-9 1994 This suggests that lumbrokinase-immobilized polyurethane digested the adsorbed fibrinogen and inhibited platelet adhesion on the surface, probably by inhibiting fibrinogen adsorption to be highly antithrombogenic. Polyurethanes 44-56 fibrinogen beta chain Homo sapiens 79-89 7814434-9 1994 This suggests that lumbrokinase-immobilized polyurethane digested the adsorbed fibrinogen and inhibited platelet adhesion on the surface, probably by inhibiting fibrinogen adsorption to be highly antithrombogenic. Polyurethanes 44-56 fibrinogen beta chain Homo sapiens 161-171 7519850-0 1994 Tetrafibricin, a novel non-peptide fibrinogen receptor antagonist, induces conformational changes in glycoprotein IIb/IIIa. tetrafibricin 0-13 fibrinogen beta chain Homo sapiens 35-45 7519850-1 1994 Arg-Gly-Asp (RGD) is an amino acid sequence in fibrinogen recognized by platelet glycoprotein (GP) IIb/IIIa. arginyl-glycyl-aspartic acid 0-11 fibrinogen beta chain Homo sapiens 47-57 7841300-0 1994 Fibrinogen Milano V: a congenital dysfibrinogenaemia with a gamma 275 Arg-->Cys substitution. Arginine 70-73 fibrinogen beta chain Homo sapiens 0-10 7841300-0 1994 Fibrinogen Milano V: a congenital dysfibrinogenaemia with a gamma 275 Arg-->Cys substitution. Cysteine 79-82 fibrinogen beta chain Homo sapiens 0-10 7841300-9 1994 Immunoblotting analysis with a rabbit antiserum against human serum albumin indicated that albumin was not linked to the odd sulphydryl group of fibrinogen Milano V. Treatment of fibrinogen Milano V with cysteamine, that is surmised to convert the mutant cysteine to a positively charged lysine analogue, did not improve the clotting properties of fibrinogen Milano V. Cysteamine 204-214 fibrinogen beta chain Homo sapiens 179-189 7841300-9 1994 Immunoblotting analysis with a rabbit antiserum against human serum albumin indicated that albumin was not linked to the odd sulphydryl group of fibrinogen Milano V. Treatment of fibrinogen Milano V with cysteamine, that is surmised to convert the mutant cysteine to a positively charged lysine analogue, did not improve the clotting properties of fibrinogen Milano V. Cysteamine 204-214 fibrinogen beta chain Homo sapiens 179-189 7841309-3 1994 Zymosan-treated plasma with 87% complement activation as measured by C3a production using radioimmunoassay was found to induce changes in biophysical characteristics of fibrin network developed in both plasma and purified fibrinogen solution. Zymosan 0-7 fibrinogen beta chain Homo sapiens 222-232 7841314-0 1994 Freeze-dried fibrinogen or fibrinogen in EDTA stimulate the tissue-type plasminogen activator-catalysed conversion of plasminogen to plasmin. Edetic Acid 41-45 fibrinogen beta chain Homo sapiens 13-23 7841314-0 1994 Freeze-dried fibrinogen or fibrinogen in EDTA stimulate the tissue-type plasminogen activator-catalysed conversion of plasminogen to plasmin. Edetic Acid 41-45 fibrinogen beta chain Homo sapiens 27-37 7519620-7 1994 Protein tyrosine phosphorylation increased in PMN plated on fibrinogen and this phosphorylation was enhanced by TNF. Tyrosine 8-16 fibrinogen beta chain Homo sapiens 60-70 7519620-11 1994 We found that the fgr protein-tyrosine kinase (p58fgr) activity, and its extent of phosphorylation in tyrosine, in PMN adherent to fibrinogen, was enhanced by TNF. Tyrosine 30-38 fibrinogen beta chain Homo sapiens 131-141 7831660-7 1994 Fibrin clot formation with thrombin of this remnant fibrinogen molecule was defective, with poor polymerization of fibrin monomers but normal release of FPA. fpa 153-156 fibrinogen beta chain Homo sapiens 52-62 7518445-1 1994 PAC1 is an IgM kappa murine monoclonal antibody that, like the Arg-Gly-Asp-containing ligand fibrinogen, binds to integrin alpha IIb beta 3 only on activated platelets. Arginine 63-66 fibrinogen beta chain Homo sapiens 93-103 7518445-1 1994 PAC1 is an IgM kappa murine monoclonal antibody that, like the Arg-Gly-Asp-containing ligand fibrinogen, binds to integrin alpha IIb beta 3 only on activated platelets. Glycine 67-70 fibrinogen beta chain Homo sapiens 93-103 7518445-1 1994 PAC1 is an IgM kappa murine monoclonal antibody that, like the Arg-Gly-Asp-containing ligand fibrinogen, binds to integrin alpha IIb beta 3 only on activated platelets. Aspartic Acid 71-74 fibrinogen beta chain Homo sapiens 93-103 7518445-9 1994 Binding of fibrinogen or PAC1 IgM to platelets induced tyrosine phosphorylation of a 140-kDa platelet protein, but binding of PAC1 Fab did not. Tyrosine 55-63 fibrinogen beta chain Homo sapiens 11-21 8037704-2 1994 Albolabrin, bitistatin, echistatin, and eristostatin bind to the platelet fibrinogen receptor (GPIIb/IIIa) acting thus as potent inhibitors of platelet aggregation. albolabrin 0-10 fibrinogen beta chain Homo sapiens 74-84 8037704-2 1994 Albolabrin, bitistatin, echistatin, and eristostatin bind to the platelet fibrinogen receptor (GPIIb/IIIa) acting thus as potent inhibitors of platelet aggregation. bitistatin 12-22 fibrinogen beta chain Homo sapiens 74-84 8037704-2 1994 Albolabrin, bitistatin, echistatin, and eristostatin bind to the platelet fibrinogen receptor (GPIIb/IIIa) acting thus as potent inhibitors of platelet aggregation. echistatin 24-34 fibrinogen beta chain Homo sapiens 74-84 8037704-2 1994 Albolabrin, bitistatin, echistatin, and eristostatin bind to the platelet fibrinogen receptor (GPIIb/IIIa) acting thus as potent inhibitors of platelet aggregation. eristostatin 40-52 fibrinogen beta chain Homo sapiens 74-84 8018671-7 1994 Coagulation inhibition may be related to HDL phospholipids: in control subjects they correlated directly with clotting times of platelet-rich and -poor plasma and inversely with fibrinogen. Phospholipids 45-58 fibrinogen beta chain Homo sapiens 178-188 7923477-1 1994 An abnormal fibrinogen that caused aggregation of red blood cells (RBC) in a patient with gangrene was examined by real-time X-ray diffraction to determine its effects on dipalmitoylphosphatidylcholine (DPPC) and 1-palmitoyl-2-oleoylphosphatidylethanolamine (POPE) phase transitions. 1,2-Dipalmitoylphosphatidylcholine 171-201 fibrinogen beta chain Homo sapiens 12-22 7923477-1 1994 An abnormal fibrinogen that caused aggregation of red blood cells (RBC) in a patient with gangrene was examined by real-time X-ray diffraction to determine its effects on dipalmitoylphosphatidylcholine (DPPC) and 1-palmitoyl-2-oleoylphosphatidylethanolamine (POPE) phase transitions. 1,2-Dipalmitoylphosphatidylcholine 203-207 fibrinogen beta chain Homo sapiens 12-22 7923477-1 1994 An abnormal fibrinogen that caused aggregation of red blood cells (RBC) in a patient with gangrene was examined by real-time X-ray diffraction to determine its effects on dipalmitoylphosphatidylcholine (DPPC) and 1-palmitoyl-2-oleoylphosphatidylethanolamine (POPE) phase transitions. 1-palmitoyl-2-oleoylphosphatidylethanolamine 213-257 fibrinogen beta chain Homo sapiens 12-22 8062509-13 1994 Fibrinogen binding in response to "weak" agonist stimulation, by low concentrations of ADP or, in a subgroup by adrenaline, was in fact lower in the normal pregnant women than in the non-pregnant women. Adenosine Diphosphate 87-90 fibrinogen beta chain Homo sapiens 0-10 8062509-13 1994 Fibrinogen binding in response to "weak" agonist stimulation, by low concentrations of ADP or, in a subgroup by adrenaline, was in fact lower in the normal pregnant women than in the non-pregnant women. Epinephrine 112-122 fibrinogen beta chain Homo sapiens 0-10 7925882-7 1994 Histamine produced significant mucosal exudation of albumin and fibrinogen, compared to control subjects. Histamine 0-9 fibrinogen beta chain Homo sapiens 64-74 8188338-2 1994 Flow cytometry using fluorescein isothiocyanate-conjugated fibrinogen confirmed that binding of human fibrinogen to the conidia was dose dependent and specific. Fluorescein-5-isothiocyanate 21-47 fibrinogen beta chain Homo sapiens 59-69 8188338-2 1994 Flow cytometry using fluorescein isothiocyanate-conjugated fibrinogen confirmed that binding of human fibrinogen to the conidia was dose dependent and specific. Fluorescein-5-isothiocyanate 21-47 fibrinogen beta chain Homo sapiens 102-112 7929473-18 1994 After amantadine, an inhibitor of protein endocytosis, both CgA and fibrinogen rose, while NA and NPY remained unaltered. Amantadine 6-16 fibrinogen beta chain Homo sapiens 68-78 7850250-1 1994 A semi-micro method (BR BLUE) is presented using Coomassie Brilliant Blue G-250 color reagent for the determination of fibrinogen on potentially turbid specimens. br blue 21-28 fibrinogen beta chain Homo sapiens 119-129 7981844-3 1994 In both genders univariate analyses revealed significantly positive correlations between plasma fibrinogen and age, body mass index (BMI), waist/hip ratio (WHR), systolic blood pressure, serum cholesterol and triglycerides and a negative correlation to high-density lipoprotein (HDL) cholesterol; however, the degree of relationship varied between men and women. Cholesterol 193-204 fibrinogen beta chain Homo sapiens 96-106 7981844-3 1994 In both genders univariate analyses revealed significantly positive correlations between plasma fibrinogen and age, body mass index (BMI), waist/hip ratio (WHR), systolic blood pressure, serum cholesterol and triglycerides and a negative correlation to high-density lipoprotein (HDL) cholesterol; however, the degree of relationship varied between men and women. Triglycerides 209-222 fibrinogen beta chain Homo sapiens 96-106 7981844-3 1994 In both genders univariate analyses revealed significantly positive correlations between plasma fibrinogen and age, body mass index (BMI), waist/hip ratio (WHR), systolic blood pressure, serum cholesterol and triglycerides and a negative correlation to high-density lipoprotein (HDL) cholesterol; however, the degree of relationship varied between men and women. Cholesterol 284-295 fibrinogen beta chain Homo sapiens 96-106 7981844-7 1994 Furthermore, the association of fibrinogen to HDL cholesterol was significant only in men and to triglycerides only in women. Cholesterol 50-61 fibrinogen beta chain Homo sapiens 32-42 7981844-7 1994 Furthermore, the association of fibrinogen to HDL cholesterol was significant only in men and to triglycerides only in women. Triglycerides 97-110 fibrinogen beta chain Homo sapiens 32-42 8083588-1 1994 Fibrinogen binding to platelets is multiphasic and culminates in the stabilization of platelet-fibrinogen interactions characterized by the resistance of bound fibrinogen to dissociation by ethylenediaminetetraacetic acid (EDTA) or excess unlabeled fibrinogen. Edetic Acid 190-221 fibrinogen beta chain Homo sapiens 0-10 8083588-1 1994 Fibrinogen binding to platelets is multiphasic and culminates in the stabilization of platelet-fibrinogen interactions characterized by the resistance of bound fibrinogen to dissociation by ethylenediaminetetraacetic acid (EDTA) or excess unlabeled fibrinogen. Edetic Acid 190-221 fibrinogen beta chain Homo sapiens 95-105 8083588-1 1994 Fibrinogen binding to platelets is multiphasic and culminates in the stabilization of platelet-fibrinogen interactions characterized by the resistance of bound fibrinogen to dissociation by ethylenediaminetetraacetic acid (EDTA) or excess unlabeled fibrinogen. Edetic Acid 223-227 fibrinogen beta chain Homo sapiens 0-10 8083588-1 1994 Fibrinogen binding to platelets is multiphasic and culminates in the stabilization of platelet-fibrinogen interactions characterized by the resistance of bound fibrinogen to dissociation by ethylenediaminetetraacetic acid (EDTA) or excess unlabeled fibrinogen. Edetic Acid 223-227 fibrinogen beta chain Homo sapiens 95-105 7933735-5 1994 Fibrinogen was also preserved to some extent by argatroban treatment without evidence of systemic embolization. argatroban 48-58 fibrinogen beta chain Homo sapiens 0-10 8049427-5 1994 DTT has been shown to expose the fibrinogen receptor on normal platelets. Dithiothreitol 0-3 fibrinogen beta chain Homo sapiens 33-43 8049427-6 1994 DTT treatment of GTV platelets did result in the formation of the fibrinogen binding site as indicated by the binding of pI-55, an MoAb that only binds to the activated form of alpha IIb beta 3. Dithiothreitol 0-3 fibrinogen beta chain Homo sapiens 66-76 8049427-7 1994 Furthermore, DTT-treated GTV platelets aggregated in the presence of fibrinogen and divalent cations. Dithiothreitol 13-16 fibrinogen beta chain Homo sapiens 69-79 7519416-5 1994 Furthermore, a significant correlation was found between some of these plasma acute-phase proteins (ACT, AMG, and FIB) and plasma TSA in the MI patients and also in normal subjects (ACT, AMG, CRP, and FIB). trichostatin A 130-133 fibrinogen beta chain Homo sapiens 114-117 7519416-5 1994 Furthermore, a significant correlation was found between some of these plasma acute-phase proteins (ACT, AMG, and FIB) and plasma TSA in the MI patients and also in normal subjects (ACT, AMG, CRP, and FIB). trichostatin A 130-133 fibrinogen beta chain Homo sapiens 201-204 7986948-1 1994 Adsorption of albumin (HSA) and fibrinogen (Fib) from human blood plasma onto titanium surfaces with varying oxide properties was studied with an enzyme-linked immunosorbent assay. Titanium 78-86 fibrinogen beta chain Homo sapiens 44-47 7606627-8 1994 A significant positive correlation was found between fibrinogen and total-cholesterol levels, but not between fibrinogen and body-mass index or systolic or diastolic blood pressures. Cholesterol 74-85 fibrinogen beta chain Homo sapiens 53-63 7992249-0 1994 How does ticlopidine treatment lower plasma fibrinogen? Ticlopidine 9-20 fibrinogen beta chain Homo sapiens 44-54 7974388-5 1994 SK&F 106760 inhibited biotinylated fibrinogen binding to purified human GPIIb/IIIa immobilized on plastic microtitre plates with a Ki of 477 +/- 57 pM. amicloral 0-6 fibrinogen beta chain Homo sapiens 39-49 7974388-9 1994 SK&F 106760 produced insurmountable inhibition of adenosine diphosphate-induced platelet aggregation in the presence of constant fibrinogen concentrations, but produced competitive inhibition of the concentration-response curve to fibrinogen in adenosine diphosphate-activated platelets with a Kb of 8.0 +/- 1.0 nM. amicloral 0-6 fibrinogen beta chain Homo sapiens 235-245 7974388-9 1994 SK&F 106760 produced insurmountable inhibition of adenosine diphosphate-induced platelet aggregation in the presence of constant fibrinogen concentrations, but produced competitive inhibition of the concentration-response curve to fibrinogen in adenosine diphosphate-activated platelets with a Kb of 8.0 +/- 1.0 nM. Adenosine Diphosphate 249-270 fibrinogen beta chain Homo sapiens 235-245 7866335-1 1994 Purified fibrinogen strongly acts as an antioxidant by inhibiting the chemiluminescent emission developed in vitro, in a cell-free system composed of luminol and hydrogen peroxide. Luminol 150-157 fibrinogen beta chain Homo sapiens 9-19 7866335-1 1994 Purified fibrinogen strongly acts as an antioxidant by inhibiting the chemiluminescent emission developed in vitro, in a cell-free system composed of luminol and hydrogen peroxide. Hydrogen Peroxide 162-179 fibrinogen beta chain Homo sapiens 9-19 7866335-6 1994 A possible correlation between the plasma level of lipid peroxides and fibrinogen was studied in different groups of patients, mostly with cardiovascular diseases and neoplasms. Lipid Peroxides 51-66 fibrinogen beta chain Homo sapiens 71-81 7866335-8 1994 In neoplasms, this correlation could not be found, in spite of the high level of fibrinogen associated with a decrease of peroxide formation, a characteristic feature of tumoral growth due to the change of fatty acids nature in the cellular membranes. Peroxides 122-130 fibrinogen beta chain Homo sapiens 81-91 7866335-8 1994 In neoplasms, this correlation could not be found, in spite of the high level of fibrinogen associated with a decrease of peroxide formation, a characteristic feature of tumoral growth due to the change of fatty acids nature in the cellular membranes. Fatty Acids 206-217 fibrinogen beta chain Homo sapiens 81-91 8071385-8 1994 The presence of air at the water-carbon interface seems to prevent the surface denaturation of fibrinogen. Water 27-32 fibrinogen beta chain Homo sapiens 95-105 8071385-8 1994 The presence of air at the water-carbon interface seems to prevent the surface denaturation of fibrinogen. Carbon 33-39 fibrinogen beta chain Homo sapiens 95-105 8071385-9 1994 The silica surface greatly denatures albumin but only slightly denatures fibrinogen. Silicon Dioxide 4-10 fibrinogen beta chain Homo sapiens 73-83 8086743-2 1994 Heparin-induced extracorporeal LDL precipitation (HELP) eliminates selectively fibrinogen, LDL cholesterol, cholesterol, triglycerides and LP(a) from the blood plasma using extracorporeal circulation. Heparin 0-7 fibrinogen beta chain Homo sapiens 79-89 7514181-6 1994 Indeed, when epinephrine was added with fibrinogen and anti-LIBS6, large platelet aggregates formed and FAK phosphorylation occurred. Epinephrine 13-24 fibrinogen beta chain Homo sapiens 40-50 7514181-10 1994 Epinephrine also promoted FAK phosphorylation and adhesive spreading of apyrase-treated platelets on a fibrinogen matrix. Epinephrine 0-11 fibrinogen beta chain Homo sapiens 103-113 8183895-4 1994 Moreover, the association of Rap2B with Triton X-100-insoluble material from platelets was totally blocked by treatment of intact platelets with monoclonal antibodies against the fibrinogen receptor glycoprotein IIb-IIIa. Octoxynol 40-52 fibrinogen beta chain Homo sapiens 179-189 8172846-6 1994 Fb was positively correlated with body mass index (r = .27 to .48, P < .001), total cholesterol (r = .13 to .17, P < .05), and low-density lipoprotein cholesterol (r = .15 to .22, P < .01) in all groups and with blood pressure, triglycerides, and cigarette smoking in white men. Cholesterol 87-98 fibrinogen beta chain Homo sapiens 0-2 8172846-6 1994 Fb was positively correlated with body mass index (r = .27 to .48, P < .001), total cholesterol (r = .13 to .17, P < .05), and low-density lipoprotein cholesterol (r = .15 to .22, P < .01) in all groups and with blood pressure, triglycerides, and cigarette smoking in white men. Triglycerides 237-250 fibrinogen beta chain Homo sapiens 0-2 8056006-0 1994 Influence of heparin on fibrinogen and D-dimer plasma levels in acute myocardial infarction treated with streptokinase. Heparin 13-20 fibrinogen beta chain Homo sapiens 24-34 8056006-1 1994 The purpose of this study was to investigate whether, to what extent, and through which mechanisms intravenous heparin, administered before and after streptokinase, affects the plasma levels of D-dimer and fibrinogen in myocardial infarction. Heparin 111-118 fibrinogen beta chain Homo sapiens 206-216 8092274-5 1994 Interaction of nonstimulated platelets with solid-phase fibrinogen was also reduced by 8-azido-ATP and ATP. Adenosine Triphosphate 95-98 fibrinogen beta chain Homo sapiens 56-66 7730877-5 1994 In men age, truncal obesity, short height and low HDL cholesterol independently predicted fibrinogen (R2 0.20) while in women obesity per se, total cholesterol, systolic blood pressure, smoking and age were predictors (R2 0.29). Cholesterol 54-65 fibrinogen beta chain Homo sapiens 90-100 7515093-2 1994 We describe a method of quantifying this receptor-ligand interaction by using flow cytometry to detect the binding of fluorescein-labeled fibrinogen to activated platelets. Fluorescein 118-129 fibrinogen beta chain Homo sapiens 138-148 7515093-3 1994 Fibrinogen conjugated with fluorescein isothiocyanate (FITC-FGN) was structurally and functionally indistinguishable from native fibrinogen when analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis, thrombin clottability, and receptor affinity studies. Fluorescein-5-isothiocyanate 27-53 fibrinogen beta chain Homo sapiens 0-10 7515093-3 1994 Fibrinogen conjugated with fluorescein isothiocyanate (FITC-FGN) was structurally and functionally indistinguishable from native fibrinogen when analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis, thrombin clottability, and receptor affinity studies. fitc-fgn 55-63 fibrinogen beta chain Homo sapiens 0-10 7515093-3 1994 Fibrinogen conjugated with fluorescein isothiocyanate (FITC-FGN) was structurally and functionally indistinguishable from native fibrinogen when analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis, thrombin clottability, and receptor affinity studies. Sodium Dodecyl Sulfate 157-179 fibrinogen beta chain Homo sapiens 0-10 7515093-3 1994 Fibrinogen conjugated with fluorescein isothiocyanate (FITC-FGN) was structurally and functionally indistinguishable from native fibrinogen when analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis, thrombin clottability, and receptor affinity studies. polyacrylamide gels 180-198 fibrinogen beta chain Homo sapiens 0-10 8091386-6 1994 Simple regression analysis detected a positive correlation between fibrinogen and age, prothrombin fragment and D-dimer, and a negative correlation between fibrinogen and HDL-cholesterol and apolipoprotein AI. Cholesterol 175-186 fibrinogen beta chain Homo sapiens 156-166 8091386-9 1994 In the 5 hyperfibrinogenemic subjects, heparin administration significantly reduced fibrinogen (625.4 +/- 211.1 vs 455.2 +/- 112.3 mg/dl, p < 0.03), prothrombin fragment (0.97 +/- 0.1 vs 0.63 +/- 0.2 nM, p < 0.002) and D-dimer (336 +/- 101.8 vs 275.2 +/- 78.5 ng/ml, p < 0.03). Heparin 39-46 fibrinogen beta chain Homo sapiens 14-24 8006045-0 1994 Interactions of plasminogen and fibrinogen with model silica glass surfaces: adsorption from plasma and enzymatic activity studies. Silicon Dioxide 54-60 fibrinogen beta chain Homo sapiens 32-42 8006045-1 1994 The adsorption of fibrinogen and plasminogen from plasma to silica glass, sulfonated silica glass, and lysine-derivatized silica glass has been investigated. Silicon Dioxide 60-66 fibrinogen beta chain Homo sapiens 18-28 8006045-2 1994 The data indicate that the sulfonated material has a high affinity for both fibrinogen and plasminogen, but that the ratio of plasminogen to fibrinogen is greater on the lysine-derivatized surface. Lysine 170-176 fibrinogen beta chain Homo sapiens 141-151 8006045-4 1994 The plasmin activity of plasminogen adsorbed to the lysine-derivatized silica glass and its sulfonated precursor was assessed by both a chromogenic substrate assay and a radioimmunoassay for the plasmin cleavage product of fibrinogen, the B beta 1-42 peptide. Lysine 52-58 fibrinogen beta chain Homo sapiens 223-233 8052959-6 1994 Factor VIIc and PAI-1 were correlated with cholesterol and triglycerides, and fibrinogen was weakly correlated with LDL-cholesterol. Cholesterol 120-131 fibrinogen beta chain Homo sapiens 78-88 8120028-7 1994 125I-Disagregin forms a specific complex with both subunits of the fibrinogen receptor, glycoproteins IIb and IIIa, in the presence of a chemical cross-linker. 125i-disagregin 0-15 fibrinogen beta chain Homo sapiens 67-77 8198250-2 1994 This study investigated whether topical glucocorticosteroid treatment influences mucosal exudation of bulk plasma (fibrinogen) and the generation of plasma-derived mediators (bradykinins) in seasonal allergic rhinitis. glucocorticosteroid 40-59 fibrinogen beta chain Homo sapiens 115-125 8084430-4 1994 STUDY DESIGN AND SUBJECTS: In this retrospective study on 139 out-patients, affected by hyperlipoproteinemia type II, the relationship between fibrinogen plasma levels and some lipid parameters, such as total cholesterol (CT), triglycerides, LDL-cholesterol, HDL-cholesterol (HDL-C), lipoprotein (a), apolipoproteins (Apo) A-I and B was evaluated. Triglycerides 227-240 fibrinogen beta chain Homo sapiens 143-153 8084430-4 1994 STUDY DESIGN AND SUBJECTS: In this retrospective study on 139 out-patients, affected by hyperlipoproteinemia type II, the relationship between fibrinogen plasma levels and some lipid parameters, such as total cholesterol (CT), triglycerides, LDL-cholesterol, HDL-cholesterol (HDL-C), lipoprotein (a), apolipoproteins (Apo) A-I and B was evaluated. Cholesterol 246-257 fibrinogen beta chain Homo sapiens 143-153 8084430-4 1994 STUDY DESIGN AND SUBJECTS: In this retrospective study on 139 out-patients, affected by hyperlipoproteinemia type II, the relationship between fibrinogen plasma levels and some lipid parameters, such as total cholesterol (CT), triglycerides, LDL-cholesterol, HDL-cholesterol (HDL-C), lipoprotein (a), apolipoproteins (Apo) A-I and B was evaluated. Cholesterol 246-257 fibrinogen beta chain Homo sapiens 143-153 8084430-5 1994 RESULTS: Fibrinogen plasma levels showed a significant inverse correlation with HDL-C (r = -0.25), HDL-C/CT (Rho = -0.22), Apo A-I (r = -0.33) serum concentration and a direct significant correlation with triglycerides serum levels (r = 0.22). Triglycerides 205-218 fibrinogen beta chain Homo sapiens 9-19 8084430-7 1994 CONCLUSION: In patients with type II hyperlipoproteinemia, the increase of fibrinogen plasma levels seems to be related to the modification of serum concentration of specific lipoprotein, such as those rich in triglycerides and those with high density. Triglycerides 210-223 fibrinogen beta chain Homo sapiens 75-85 8031988-7 1994 Adsorption of fibrinogen, in particular, was significantly reduced by the amphiphilic additives to levels similar to those obtained for Pellethane surfaces grafted with PEG 20,000. Polyurethanes 136-146 fibrinogen beta chain Homo sapiens 14-24 8031988-7 1994 Adsorption of fibrinogen, in particular, was significantly reduced by the amphiphilic additives to levels similar to those obtained for Pellethane surfaces grafted with PEG 20,000. Polyethylene Glycols 169-172 fibrinogen beta chain Homo sapiens 14-24 7519037-2 1994 With maximum ADP (10(-5) M) fibrinogen bound to 76.1 +/- 7.2% of platelets but P-selectin and CD63 antigen were expressed on 26.9 +/- 9.8% and 8.6 +/- 3.5% of platelets respectively. Adenosine Diphosphate 13-16 fibrinogen beta chain Homo sapiens 28-38 7519037-6 1994 Addition of the GPIIb-IIIa antagonist echistatin, at concentrations that totally blocked fibrinogen binding to ADP-stimulated platelets, had no effect on the expression of the granule membrane antigens. echistatin 38-48 fibrinogen beta chain Homo sapiens 89-99 7519037-6 1994 Addition of the GPIIb-IIIa antagonist echistatin, at concentrations that totally blocked fibrinogen binding to ADP-stimulated platelets, had no effect on the expression of the granule membrane antigens. Adenosine Diphosphate 111-114 fibrinogen beta chain Homo sapiens 89-99 8075176-0 1994 125I-fibrinogen: thyroid blocking with 2.5 mg potassium iodide twice daily in patients after hip surgery. Potassium Iodide 46-62 fibrinogen beta chain Homo sapiens 5-15 7998345-0 1994 [Effect of chemical modification of arginine residues of fibrinogen and its DH-fragment on the rate of hydrolysis of these proteins by plasminogen]. Arginine 36-44 fibrinogen beta chain Homo sapiens 57-67 7998345-1 1994 Plasminolysis of the fibrinogen arginine and its DH-fragment residues was sufficiently lower in contrast to that of initial proteins. Arginine 32-40 fibrinogen beta chain Homo sapiens 21-31 8117177-6 1994 Only fenofibrate decreased total triglyceride levels in type IIb, Lp(a) lipoprotein levels in patients with high baseline values, and fibrinogen. Fenofibrate 5-16 fibrinogen beta chain Homo sapiens 134-144 8117177-11 1994 However, fenofibrate exhibits a significant effect on other established risk factors, such as total triglyceride, fibrinogen, and Lp(a) lipoprotein levels, and accordingly has a broader spectrum of activity than simvastatin. Fenofibrate 9-20 fibrinogen beta chain Homo sapiens 114-124 8129189-5 1994 Picotamide induced a significant decrease of plasma viscosity, fibrinogen, and beta-thromboglobulin and an increase of amplitude of the photoplethysmographic wave. picotamide 0-10 fibrinogen beta chain Homo sapiens 63-73 8179202-6 1994 ADP and thrombin stimulated platelet adhesion in a dose-dependent manner to fibrinogen and human plasma, but not to human albumin. Adenosine Diphosphate 0-3 fibrinogen beta chain Homo sapiens 76-86 8206082-0 1994 Plasma fibrinogen in relation to serum insulin, smoking habits and adipose tissue fatty acids in healthy men. Fatty Acids 82-93 fibrinogen beta chain Homo sapiens 7-17 8206082-5 1994 The most significant difference in fibrinogen level was found among the tertiles of fasting serum insulin (F-ANOVA = 4.5; P < 0.01) with the highest plasma fibrinogen values in the third insulin tertile, whereas body mass index (BMI), waist/hip circumference ratio (WHR) and serum triglycerides were more weakly related. Triglycerides 284-297 fibrinogen beta chain Homo sapiens 35-45 8113408-6 1994 By restriction fragment length polymorphism analysis, 7 affected individuals and 14 asymptomatic individuals in these two kindreds were positive for the fibrinogen A alpha chain Val 526 gene. Valine 178-181 fibrinogen beta chain Homo sapiens 153-163 8301202-3 1994 In this study, we showed that triflavin inhibited adhesion of human hepatoma J-5 cells to extracellular matrices (fibronectin, vitronectin, fibrinogen, and collagen type I) in a dose-dependent manner. triflavin 30-39 fibrinogen beta chain Homo sapiens 140-150 8276866-0 1994 Role of interchain disulfide bonds on the assembly and secretion of human fibrinogen. Disulfides 19-28 fibrinogen beta chain Homo sapiens 74-84 8276866-1 1994 The cysteines involved in joining the 2 half-molecules of fibrinogen and also those located on either side of the alpha-helical coiled-coil region, were substituted, by site-directed mutagenesis, with serine. Cysteine 4-13 fibrinogen beta chain Homo sapiens 58-68 8276866-1 1994 The cysteines involved in joining the 2 half-molecules of fibrinogen and also those located on either side of the alpha-helical coiled-coil region, were substituted, by site-directed mutagenesis, with serine. Serine 201-207 fibrinogen beta chain Homo sapiens 58-68 8276866-8 1994 Disruption of both disulfide rings at either end of the coiled-coil region disallows assembly of half-molecules and of dimeric fibrinogen. Disulfides 19-28 fibrinogen beta chain Homo sapiens 127-137 7506054-0 1994 Epinephrine sensitizes human platelets in vivo and in vitro as studied by fibrinogen binding and P-selectin expression. Epinephrine 0-11 fibrinogen beta chain Homo sapiens 74-84 7506054-3 1994 ADP caused concentration-dependent increases in the percentage of platelets that bound fibrinogen (from 4.4 +/- 0.9% to 69.9 +/- 4.2%) and that expressed P-selectin (from 4.5 +/- 0.5% to 44.2 +/- 3.8%). Adenosine Diphosphate 0-3 fibrinogen beta chain Homo sapiens 87-97 8274476-3 1994 In contrast, platelets stimulated with 10 mumol/L ADP bound 63 734 +/- 2453 molecules of fibrinogen per platelet. Adenosine Diphosphate 50-53 fibrinogen beta chain Homo sapiens 89-99 8274476-5 1994 The increased fibrinogen binding in the presence of LDL resulted in faster aggregation with a 16% increase in single platelet disappearance and a faster optical aggregation at 5 mumol/L ADP and 1.5 g protein/L LDL. Adenosine Diphosphate 186-189 fibrinogen beta chain Homo sapiens 14-24 8274478-9 1994 Individuals in the high serum low-density lipoprotein (LDL) cholesterol tertile who also showed high plasma fibrinogen concentrations had a 6.1-fold increase in coronary risk. Cholesterol 60-71 fibrinogen beta chain Homo sapiens 108-118 8274478-10 1994 Unexpectedly, individuals with low plasma fibrinogen had a low incidence of coronary events even when serum LDL cholesterol was high. Cholesterol 112-123 fibrinogen beta chain Homo sapiens 42-52 8274478-13 1994 Thus, higher levels of plasma fibrinogen markedly increased the predictive power of high serum LDL cholesterol. Cholesterol 99-110 fibrinogen beta chain Homo sapiens 30-40 7509643-4 1994 The decrease in the fibrinogen concentration in human blood plasma caused by plasmosorption on plasminogen-Sepharose enhanced the model fibrin clot lysis by urokinase and streptokinase, however, by no more than 5-10%. Sepharose 107-116 fibrinogen beta chain Homo sapiens 20-30 8005188-5 1994 The lavage fluid levels of albumin, fibrinogen and bradykinins increased significantly after each histamine provocation. Histamine 98-107 fibrinogen beta chain Homo sapiens 36-46 8005188-6 1994 The ratio of albumin-to-fibrinogen in plasma and the lavage fluid was 24 and 56, respectively, indicating that topical histamine provocation induced a largely non-sieved flux of macromolecules across the endothelial-epithelial barriers. Histamine 119-128 fibrinogen beta chain Homo sapiens 24-34 7835384-3 1994 The fibrinogen was converted to fibrin by the addition of 0.3 part of thrombin solution, 150 NIH U/ml, containing 100 mM calcium chloride. Calcium Chloride 121-137 fibrinogen beta chain Homo sapiens 4-14 7873511-9 1994 In calibration experiments, oxide failed to adhere to slides exposed to purified albumin but adhered copiously to slides exposed to purified fibrinogen. Oxides 28-33 fibrinogen beta chain Homo sapiens 141-151 7947470-1 1994 Fibrinogen adsorbed to polymeric surfaces and then allowed to reside on the surface while it is kept in a buffer solution for a period of time (the "residence time") undergoes postadsorptive changes that decrease its SDS elutability, displaceability by plasma, polyclonal antifibrinogen binding, and ability to support platelet adhesion (summarized in Chinn et al. Sodium Dodecyl Sulfate 217-220 fibrinogen beta chain Homo sapiens 0-10 8254197-3 1994 The time course of stimulated H2O2 release from PMN plated on fibrinogen (FG) kinetically paralleled cell spreading and lactoferrin release. Hydrogen Peroxide 30-34 fibrinogen beta chain Homo sapiens 62-72 8057400-3 1994 In particular, fibrinogen was 318 +/- 10.9 mg/dL in heroin abusers, significantly higher than that of the remaining three groups; the percentage of aggregated leukocytes was 5.01 +/- 0.77 in heroin users, significantly higher than that of subjects abstaining for at least 5 months. Heroin 52-58 fibrinogen beta chain Homo sapiens 15-25 8057400-4 1994 The fibrinogen levels declined sharply with abstention and an additive effect was noted with the administration of naltrexone, but leukocyte aggregation changed more slowly, and the effect of naltrexone (if any) was weaker. Naltrexone 115-125 fibrinogen beta chain Homo sapiens 4-14 10603512-0 1994 Heparin Binding Sites Are Located in a 40-kD gamma-Chain and a 36-kD beta-Chain Fragment Isolated from Human Fibrinogen. Heparin 0-7 fibrinogen beta chain Homo sapiens 109-119 10603512-1 1994 Objective: We have previously shown that (125)I-fibrinogen binds to heparin sepharose CL-6B. Heparin 68-75 fibrinogen beta chain Homo sapiens 48-58 10603512-1 1994 Objective: We have previously shown that (125)I-fibrinogen binds to heparin sepharose CL-6B. sepharose CL 6B 76-91 fibrinogen beta chain Homo sapiens 48-58 8128455-2 1993 First, we prepared fibrinogen-coated agarose beads (fbg-beads) as a model of platelets, and subjected them to aggregometry using TSP as an inducer. Sepharose 37-44 fibrinogen beta chain Homo sapiens 19-29 8241506-2 1993 This study shows the retention of GPIIb and GPIIIa on immobilized fibrinogen after Triton X-100 (Sigma Chemical Co, St Louis, MO) lysis of adherent platelets. Octoxynol 83-95 fibrinogen beta chain Homo sapiens 66-76 8241506-7 1993 Platelet activation with Zn+2 also enhanced GPIIb and GPIIIa recovery on fibrinogen-coated surfaces over that observed with unstimulated platelets, but GPIIb and IIIa retention was EDTA sensitive. Zinc 25-29 fibrinogen beta chain Homo sapiens 73-83 8241506-8 1993 This correlated with the EDTA-reversible nature of Zn+2-activated platelet adhesion to fibrinogen-coated surfaces. Edetic Acid 25-29 fibrinogen beta chain Homo sapiens 87-97 8241506-8 1993 This correlated with the EDTA-reversible nature of Zn+2-activated platelet adhesion to fibrinogen-coated surfaces. Zinc 51-55 fibrinogen beta chain Homo sapiens 87-97 8241506-9 1993 The data (1) show that platelet adhesion to fibrinogen is accompanied by the induction of high-affinity interactions between GPIIb-IIIa and immobilized fibrinogen that are EDTA-resistant and enhanced by platelet activation with some but not all agonists, and (2) implicate these interactions in stabilizing platelet contacts with fibrinogen-coated surfaces. Edetic Acid 172-176 fibrinogen beta chain Homo sapiens 44-54 8241506-9 1993 The data (1) show that platelet adhesion to fibrinogen is accompanied by the induction of high-affinity interactions between GPIIb-IIIa and immobilized fibrinogen that are EDTA-resistant and enhanced by platelet activation with some but not all agonists, and (2) implicate these interactions in stabilizing platelet contacts with fibrinogen-coated surfaces. Edetic Acid 172-176 fibrinogen beta chain Homo sapiens 152-162 8241506-9 1993 The data (1) show that platelet adhesion to fibrinogen is accompanied by the induction of high-affinity interactions between GPIIb-IIIa and immobilized fibrinogen that are EDTA-resistant and enhanced by platelet activation with some but not all agonists, and (2) implicate these interactions in stabilizing platelet contacts with fibrinogen-coated surfaces. Edetic Acid 172-176 fibrinogen beta chain Homo sapiens 152-162 8252662-5 1993 Patients randomized to Parnaparin showed a significant decrease in the fibrinogen level (P = .035) and an improvement in both the time to 1-mm ST segment depression (P = .008) and the peak ST segment depression (P = .015). parnaparin 23-33 fibrinogen beta chain Homo sapiens 71-81 8302368-1 1993 A review of 117 research publications describes a deficiency in fatty acid transport into intracellular oxidative energy metabolism which causes increased fibrinogen synthesis and turnover into fibrin. Fatty Acids 64-74 fibrinogen beta chain Homo sapiens 155-165 8039760-4 1993 We report here the 125I-fibrinogen kinetics and FPA measurements in 19 patients with AL, 6 of them with DIC. Aluminum 85-87 fibrinogen beta chain Homo sapiens 24-34 8400260-8 1993 We conclude that the substitution gamma 337 Asn-->Lys in fibrinogen Bern I is responsible for defective polymerization of fibrin monomers and for impaired protection by calcium against plasmic degradation. Calcium 169-176 fibrinogen beta chain Homo sapiens 57-67 7888985-5 1993 Among the American Indians, plasma fibrinogen was higher in women (mean: 338 mg/dL) than in men (mean: 318 mg/dL); positively correlated (P < .05) with age, body mass index, and waist-hip ratio; and negatively correlated with serum cholesterol level. Cholesterol 235-246 fibrinogen beta chain Homo sapiens 35-45 8410097-5 1993 The association between the mean intensity of CLTPA (p = 0.030 for interaction) and VO2max (p = 0.033) and plasma fibrinogen was stronger for smokers than for non-smokers. cltpa 46-51 fibrinogen beta chain Homo sapiens 114-124 8410097-6 1993 These data indicate that a reduction of plasma fibrinogen concentration may be one mechanism through which moderate to high intensity CLTPA and high cardiorespiratory fitness reduce the risk of CHD. cltpa 134-139 fibrinogen beta chain Homo sapiens 47-57 7692141-3 1993 We determined that a heparin dose of 1 U/ml prevented clot formation in this model, but resulted in elevated plasma levels of fibrinopeptide A, the first cleavage product of fibrinogen. Heparin 21-28 fibrinogen beta chain Homo sapiens 174-184 8134906-9 1993 Monoclonal antibodies against platelet membrane GPIIb-IIIa, potent inhibitors of ADP-induced fibrinogen binding to platelets, completely inhibited adhesion. Adenosine Diphosphate 81-84 fibrinogen beta chain Homo sapiens 93-103 8251004-8 1993 [95% CI]) levels of fibrinogen from lowest to highest categories were: 3.49 (1.10 [2.99, 3.99]), 3.31 (1.52 [2.82, 3.81]), and 3.20 (2.26 [2.73, 3.67]) g/l, respectively, when age, body mass index (BMI), smoking, alcohol intake, LDL-cholesterol and estrogen use were allowed for (P = 0.021). Alcohols 213-220 fibrinogen beta chain Homo sapiens 20-30 8251004-8 1993 [95% CI]) levels of fibrinogen from lowest to highest categories were: 3.49 (1.10 [2.99, 3.99]), 3.31 (1.52 [2.82, 3.81]), and 3.20 (2.26 [2.73, 3.67]) g/l, respectively, when age, body mass index (BMI), smoking, alcohol intake, LDL-cholesterol and estrogen use were allowed for (P = 0.021). Cholesterol 233-244 fibrinogen beta chain Homo sapiens 20-30 8360253-12 1993 A rationale for co-packaging these components within the alpha-granules is that Zn(II) inhibits factor XIII activity and thereby prevents the premature cross-linking of the concentrated fibrinogen prior to platelet activation and secretion. Zinc 80-86 fibrinogen beta chain Homo sapiens 186-196 8395822-4 1993 CLA inhibited the exposure of fibrinogen receptor in a dose related manner when added either before or 3 min after thrombin stimulation. calyculin A 0-3 fibrinogen beta chain Homo sapiens 30-40 8198250-9 1994 In spite of the low pollen exposure, treatment with budesonide reduced the lavage fluid levels of both bradykinins and fibrinogen. Budesonide 52-62 fibrinogen beta chain Homo sapiens 119-129 7830855-10 1994 In the steroid-resistant patients, the only significant changes observed were decreased fibrinogen and increased protein C. Steroids 7-14 fibrinogen beta chain Homo sapiens 88-98 8280448-4 1994 With the administration of VPA without ACTH-Zn, the lowest blood Fbg levels were 232, 108 and 170 mg/dl (mean 170 mg/dl), respectively. Valproic Acid 27-30 fibrinogen beta chain Homo sapiens 65-68 8280448-9 1994 The concentration of VPA and the blood level of Fbg were found inversely correlated with a correlation coefficient of -0.22 (p < 0.01) in 150 serum samples from 91 patients with childhood epilepsy treated with VPA without ACTH-Zn. acth-zn 225-232 fibrinogen beta chain Homo sapiens 48-51 8280448-10 1994 In the three cases presented, the combination with ACTH-Zn resulted in considerably lower blood Fbg levels than those predicted from the blood VPA concentrations. acth-zn 51-58 fibrinogen beta chain Homo sapiens 96-99 8280448-11 1994 This indicates that the combination of ACTH-Zn and VPA induces a further decrease of Fbg in blood. acth-zn 39-46 fibrinogen beta chain Homo sapiens 85-88 8280448-11 1994 This indicates that the combination of ACTH-Zn and VPA induces a further decrease of Fbg in blood. Valproic Acid 51-54 fibrinogen beta chain Homo sapiens 85-88 7700842-3 1994 In this study, we show that triflavin dose-dependently inhibited adhesion of human cervical carcinoma (HeLa) cells to extracellular matrices (ECMs; i.e., fibronectin, fibrinogen, and vitronectin). triflavin 28-37 fibrinogen beta chain Homo sapiens 167-177 7938179-8 1994 n-3 FA reduce platelet aggregation, blood viscosity, plasma levels of fibrinogen, PF4 and beta-thromboglobulin and increase capillary flow and red cell membrane fluidity, but their long-term effects on cardiovascular mortality are largely unknown. Fatty Acids, Omega-3 0-6 fibrinogen beta chain Homo sapiens 70-80 8165650-2 1994 The effect of shear rate and fibrinogen concentration on adenosine diphosphate-induced aggregation of suspensions of washed human platelets in Poiseuille flow at 23 degrees C was studied using a previously described double infusion technique and resistive particle counter size analysis. Adenosine Diphosphate 57-78 fibrinogen beta chain Homo sapiens 29-39 7716823-0 1994 Inhibition of fibrinogen binding to platelets by MK-852, a new GPIIb/IIIa antagonist. MK 0852 49-55 fibrinogen beta chain Homo sapiens 14-24 7716823-1 1994 MK-852 is a newly developed low molecular weight inhibitor of fibrinogen binding to platelets. MK 0852 0-6 fibrinogen beta chain Homo sapiens 62-72 7716823-6 1994 We have used flow cytometry and FITC-labelled chicken anti-human fibrinogen antibodies to study the in vitro inhibitory effects of MK-852 on fibrinogen binding to platelets. MK 0852 131-137 fibrinogen beta chain Homo sapiens 141-151 7716823-7 1994 We show that MK-852 is a very efficient fibrinogen receptor antagonist in vitro. MK 0852 13-19 fibrinogen beta chain Homo sapiens 40-50 8553608-1 1994 Chloride-citrate-glucose solution was used in fibrinogen preparation for intravenous administration. chloride-citrate-glucose 0-24 fibrinogen beta chain Homo sapiens 46-56 8553608-2 1994 Concentrated hydrochloric acid previously used for preparation of buffers for fibrinogen has been replaced by the diluted one enabling easier and more precise buffer pH regulation and faster fibrinogen dissolution. Hydrochloric Acid 13-30 fibrinogen beta chain Homo sapiens 78-88 8553608-2 1994 Concentrated hydrochloric acid previously used for preparation of buffers for fibrinogen has been replaced by the diluted one enabling easier and more precise buffer pH regulation and faster fibrinogen dissolution. Hydrochloric Acid 13-30 fibrinogen beta chain Homo sapiens 191-201 8262952-9 1993 The 29-kDa fragment inhibited ADP-induced aggregation of platelets and binding of fibrinogen to activated platelets. Adenosine Diphosphate 30-33 fibrinogen beta chain Homo sapiens 82-92 7903170-5 1993 Sequence analysis of these aberrant peptides and isolated A alpha chains of the patient"s fibrinogen showed that Glu at position 11 of the abnormal A alpha chain had been replaced by Gly. Glutamic Acid 113-116 fibrinogen beta chain Homo sapiens 90-100 7903170-5 1993 Sequence analysis of these aberrant peptides and isolated A alpha chains of the patient"s fibrinogen showed that Glu at position 11 of the abnormal A alpha chain had been replaced by Gly. Glycine 183-186 fibrinogen beta chain Homo sapiens 90-100 7903170-6 1993 Studies using 125I-labeled thrombin showed that the binding with thrombin was evidently reduced for her fibrinogen and the aberrant fibrinopeptide A as compared with that for the normal controls, indicating that A alpha Glu-11 may be critical for the fibrinogen-thrombin interaction. Iodine-125 14-18 fibrinogen beta chain Homo sapiens 104-114 7903170-7 1993 Indeed, A alpha Glu-11 of fibrinogen has recently been proposed to stabilize the local conformation, including the beta-turn, and to form a salt bridge between its side-chain carboxyl group and the guanidino group of Arg-173 of thrombin based on crystallographic analyses using analogs of fibrinopeptide A complexed with thrombin (Stubb et al, Eur J Biochem 206:187, 1992 and Martin et al, J Biol Chem 267:7911, 1992). Glutamic Acid 16-19 fibrinogen beta chain Homo sapiens 26-36 7903170-7 1993 Indeed, A alpha Glu-11 of fibrinogen has recently been proposed to stabilize the local conformation, including the beta-turn, and to form a salt bridge between its side-chain carboxyl group and the guanidino group of Arg-173 of thrombin based on crystallographic analyses using analogs of fibrinopeptide A complexed with thrombin (Stubb et al, Eur J Biochem 206:187, 1992 and Martin et al, J Biol Chem 267:7911, 1992). Arginine 217-220 fibrinogen beta chain Homo sapiens 26-36 8266905-4 1993 Fibrinogen (overall mean +/- standard deviation = 263 +/- 57 mg/dl) was greater in women than in men and in blacks than in whites; it was associated positively with cigarette smoking, body mass index, low density lipoprotein cholesterol, triglycerides, and blood pressure, and negatively with physical activity, high density lipoprotein cholesterol, and ethanol intake. Triglycerides 238-251 fibrinogen beta chain Homo sapiens 0-10 8266905-4 1993 Fibrinogen (overall mean +/- standard deviation = 263 +/- 57 mg/dl) was greater in women than in men and in blacks than in whites; it was associated positively with cigarette smoking, body mass index, low density lipoprotein cholesterol, triglycerides, and blood pressure, and negatively with physical activity, high density lipoprotein cholesterol, and ethanol intake. Ethanol 354-361 fibrinogen beta chain Homo sapiens 0-10 8160557-4 1993 Following mesoglycan treatment we observed a statistically significant decrease in fibrinogen plasma concentration, total cholesterol and triglycerides, while HDL cholesterol was found to increase. mesoglycan 10-20 fibrinogen beta chain Homo sapiens 83-93 8303683-0 1993 Tetrafibricin: a nonpeptidic fibrinogen receptor inhibitor from Streptomyces neyagawaensis. tetrafibricin 0-13 fibrinogen beta chain Homo sapiens 29-39 8303683-3 1993 Tetrafibricin; a nonpeptidic fibrinogen inhibitor from microbial origin, showed potent antiaggregation activities on human platelet aggregation induced by either ADP, thrombin or collagen (IC50s = 5.6, 7.6 and 11 microM, respectively) in platelet rich plasma. tetrafibricin 0-13 fibrinogen beta chain Homo sapiens 29-39 8303683-9 1993 Tetrafibricin is the first nonpeptidic fibrinogen receptor inhibitor that may be valuable for the study on platelet aggregation inhibitors. tetrafibricin 0-13 fibrinogen beta chain Homo sapiens 39-49 21244912-3 1993 Tyrosine phosphorylation of several platelet proteins is regulated by fibrinogen binding to its integrin receptor and subsequent platelet aggregation, suggesting specific functions for tyrosine phosphorylation in integrin-regulated intracellular processes. Tyrosine 0-8 fibrinogen beta chain Homo sapiens 70-80 21244912-3 1993 Tyrosine phosphorylation of several platelet proteins is regulated by fibrinogen binding to its integrin receptor and subsequent platelet aggregation, suggesting specific functions for tyrosine phosphorylation in integrin-regulated intracellular processes. Tyrosine 185-193 fibrinogen beta chain Homo sapiens 70-80 8115992-9 1993 The patients had a significantly higher median percentage of circulating platelets with bound fibrinogen (p < 0.005), but fibrinogen binding was significantly lower (p < 0.02) in response to 10(-5) M ADP, compared to twelve age-matched normal controls. Adenosine Diphosphate 206-209 fibrinogen beta chain Homo sapiens 125-135 8211041-1 1993 Previous studies have demonstrated that heparin-induced extracorporeal LDL precipitation is able to reduce total cholesterol, LDL, triglycerides and plasma fibrinogen at the same time and thus improve the hemorheologic pattern. Heparin 40-47 fibrinogen beta chain Homo sapiens 156-166 8211041-3 1993 and bezafibrate, which also has a lipid- and fibrinogen-lowering potency, was applied in patients suffering from cerebral multi-infarct dementia and disturbances of the hemorheologic situation. Bezafibrate 4-15 fibrinogen beta chain Homo sapiens 45-55 8266923-2 1993 Circulating immune complexes (CIC) were the main factor in the inhibition of GPIIb/IIIa binding to fibrinogen in HIV-related ITP, whereas in non-HIV ITP, inhibition was only partially due to CIC; anti-platelet antibodies specific to GPIIIa were also shown to play a role. cic 30-33 fibrinogen beta chain Homo sapiens 99-109 8266923-6 1993 In HIV-seronegative ITP patients, the decrease or disappearance of anti-platelet antibodies directly correlated with the decreased inhibition of GPIIb/IIIa binding to fibrinogen by the 2% PEG supernatants of sera which contained anti-platelet antibodies. Polyethylene Glycols 188-191 fibrinogen beta chain Homo sapiens 167-177 8280181-3 1993 Fibrinogen was bound in significantly higher amounts (P < 0.02) to hyperlipidaemic platelets activated by ADP than to control ones (107,112 +/- 16,371 and 45,612 +/- 6495 molecules per platelet, respectively). Adenosine Diphosphate 109-112 fibrinogen beta chain Homo sapiens 0-10 8280181-5 1993 The amount of fibrinogen bound to the activated hyperlipidaemic platelets showed a positive correlation with total plasma cholesterol and LDL (r = 0.45 and 0.47, respectively) whereas a negative correlation with plasma HDL was found (r = -0.50). Cholesterol 122-133 fibrinogen beta chain Homo sapiens 14-24 8280181-6 1993 The increased expression of fibrinogen binding sites similar to that of hyperlipidaemic platelets could be produced by preincubation of normal platelets with palmitic acid. Palmitic Acid 158-171 fibrinogen beta chain Homo sapiens 28-38 8292718-9 1993 Using differential scanning calorimetry, it was observed that the two domains (D and E) of fibrinogen were modified by ioxaglate, showing the absence of specificity in the interaction between ioxaglate and a particular domain. Ioxaglic Acid 119-128 fibrinogen beta chain Homo sapiens 91-101 8280606-7 1993 Moreover, after pretreatment with the anti-fibrinogen antibody and fibrinogen, formalin-fixed platelets bound to fibrinogen saturably. Formaldehyde 79-87 fibrinogen beta chain Homo sapiens 43-53 8280606-7 1993 Moreover, after pretreatment with the anti-fibrinogen antibody and fibrinogen, formalin-fixed platelets bound to fibrinogen saturably. Formaldehyde 79-87 fibrinogen beta chain Homo sapiens 67-77 8280606-7 1993 Moreover, after pretreatment with the anti-fibrinogen antibody and fibrinogen, formalin-fixed platelets bound to fibrinogen saturably. Formaldehyde 79-87 fibrinogen beta chain Homo sapiens 67-77 8269798-4 1993 RESULTS: Fasting glucose, HbA1c, fasting and glucose-stimulated insulin, blood pressure and left ventricular mass, cholesterol, triglycerides, and fibrinogen decreased significantly after metformin treatment, whereas high-density lipoprotein cholesterol increased. Metformin 188-197 fibrinogen beta chain Homo sapiens 147-157 8224117-6 1993 A specific concentration of the antigens was found on membrane ruffles and microvilli, sites to which FITC-labeled fibrinogen also bound. Fluorescein-5-isothiocyanate 102-106 fibrinogen beta chain Homo sapiens 115-125 8228555-2 1993 Testosterone correlated positively with the major stimulator of fibrinolysis, tissue plasminogen activator activity (r = 0.30; p = 0.02) and correlated inversely with two independent coronary heart disease risk factors, plasminogen activator inhibitor activity, the major fibrinolysis inhibitor (r = -0.33; p = 0.01), and fibrinogen (r = -0.39; p = 0.004). Testosterone 0-12 fibrinogen beta chain Homo sapiens 322-332 8228555-5 1993 Testosterone was an inverse, independent predictor of fibrinogen (p = 0.002); 53% of the variance of fibrinogen could be accounted for by age and triglyceride level (positive; p = 0.001, p = 0.01), and by apolipoprotein A-I and testosterone (negative; p = 0.02, p = 0.002). Testosterone 0-12 fibrinogen beta chain Homo sapiens 54-64 8228555-5 1993 Testosterone was an inverse, independent predictor of fibrinogen (p = 0.002); 53% of the variance of fibrinogen could be accounted for by age and triglyceride level (positive; p = 0.001, p = 0.01), and by apolipoprotein A-I and testosterone (negative; p = 0.02, p = 0.002). Triglycerides 146-158 fibrinogen beta chain Homo sapiens 101-111 8228555-5 1993 Testosterone was an inverse, independent predictor of fibrinogen (p = 0.002); 53% of the variance of fibrinogen could be accounted for by age and triglyceride level (positive; p = 0.001, p = 0.01), and by apolipoprotein A-I and testosterone (negative; p = 0.02, p = 0.002). Testosterone 228-240 fibrinogen beta chain Homo sapiens 101-111 8232678-3 1993 Heparin-induced extracorporeal LDL precipitation (HELP) is a method that effectively reduces fibrinogen and lipoproteins at the same time, thus improving the hemorheologic pattern. Heparin 0-7 fibrinogen beta chain Homo sapiens 93-103 8378944-2 1993 Heparin-induced extracorporeal low density lipoprotein precipitation (HELP) is a new method that safely and effectively reduces fibrinogen and plasma lipoproteins and improves blood flow properties. Heparin 0-7 fibrinogen beta chain Homo sapiens 128-138 8373370-5 1993 In addition, the values of Km for thrombin-fibrinogen reaction were measured at different solution viscosities in order to derive the equilibrium dissociation constant, Ks, of this interaction. Potassium 169-171 fibrinogen beta chain Homo sapiens 43-53 8373370-6 1993 These experiments showed that the Ks values for thrombin-fibrinogen binding was equal to 1.8 microM at 25 degrees C. Altogether these results indicated that fibrinogen, though interacting with both the catalytic pocket and the fibrinogen recognition site on the thrombin molecule, dissociates from Michaelis complex with a rate comparable with that shown by amide substrates, which interact only with the catalytic site. Potassium 34-36 fibrinogen beta chain Homo sapiens 57-67 8373370-6 1993 These experiments showed that the Ks values for thrombin-fibrinogen binding was equal to 1.8 microM at 25 degrees C. Altogether these results indicated that fibrinogen, though interacting with both the catalytic pocket and the fibrinogen recognition site on the thrombin molecule, dissociates from Michaelis complex with a rate comparable with that shown by amide substrates, which interact only with the catalytic site. Potassium 34-36 fibrinogen beta chain Homo sapiens 157-167 8373370-6 1993 These experiments showed that the Ks values for thrombin-fibrinogen binding was equal to 1.8 microM at 25 degrees C. Altogether these results indicated that fibrinogen, though interacting with both the catalytic pocket and the fibrinogen recognition site on the thrombin molecule, dissociates from Michaelis complex with a rate comparable with that shown by amide substrates, which interact only with the catalytic site. Potassium 34-36 fibrinogen beta chain Homo sapiens 157-167 8373370-6 1993 These experiments showed that the Ks values for thrombin-fibrinogen binding was equal to 1.8 microM at 25 degrees C. Altogether these results indicated that fibrinogen, though interacting with both the catalytic pocket and the fibrinogen recognition site on the thrombin molecule, dissociates from Michaelis complex with a rate comparable with that shown by amide substrates, which interact only with the catalytic site. Amides 358-363 fibrinogen beta chain Homo sapiens 57-67 8373370-6 1993 These experiments showed that the Ks values for thrombin-fibrinogen binding was equal to 1.8 microM at 25 degrees C. Altogether these results indicated that fibrinogen, though interacting with both the catalytic pocket and the fibrinogen recognition site on the thrombin molecule, dissociates from Michaelis complex with a rate comparable with that shown by amide substrates, which interact only with the catalytic site. Amides 358-363 fibrinogen beta chain Homo sapiens 157-167 8373370-6 1993 These experiments showed that the Ks values for thrombin-fibrinogen binding was equal to 1.8 microM at 25 degrees C. Altogether these results indicated that fibrinogen, though interacting with both the catalytic pocket and the fibrinogen recognition site on the thrombin molecule, dissociates from Michaelis complex with a rate comparable with that shown by amide substrates, which interact only with the catalytic site. Amides 358-363 fibrinogen beta chain Homo sapiens 157-167 10603512-2 1994 To identify the localization of the heparin binding domain in human fibrinogen, reduced and alkylated fibrinogen was digested by limited-Staphylococcus aureus V8 protease. Heparin 36-43 fibrinogen beta chain Homo sapiens 68-78 10603512-2 1994 To identify the localization of the heparin binding domain in human fibrinogen, reduced and alkylated fibrinogen was digested by limited-Staphylococcus aureus V8 protease. Heparin 36-43 fibrinogen beta chain Homo sapiens 102-112 10603512-6 1994 Binding of (125)I-fibrinogen to heparin-sepharose CL-6B was completely inhibited by a mixture of these fragments, with an IC(50) of 3.2 microM. Heparin 32-39 fibrinogen beta chain Homo sapiens 18-28 10603512-6 1994 Binding of (125)I-fibrinogen to heparin-sepharose CL-6B was completely inhibited by a mixture of these fragments, with an IC(50) of 3.2 microM. sepharose CL 6B 40-55 fibrinogen beta chain Homo sapiens 18-28 10603512-9 1994 Conclusions: These data indicate that the domains for heparin binding may be present on both the gamma chain and the beta chain of fibrinogen, and that the domain on the gamma chain may be close to the binding domain on the carboxy terminus of the fibrinogen gamma chain to glycoprotein IIb-IIIa. Heparin 54-61 fibrinogen beta chain Homo sapiens 131-141 8396029-0 1993 ADP-stimulated fibrinogen binding is necessary for some of the inositol phospholipid changes found in ADP-stimulated platelets. Adenosine Diphosphate 0-3 fibrinogen beta chain Homo sapiens 15-25 8396029-0 1993 ADP-stimulated fibrinogen binding is necessary for some of the inositol phospholipid changes found in ADP-stimulated platelets. Phosphatidylinositols 63-84 fibrinogen beta chain Homo sapiens 15-25 8396029-0 1993 ADP-stimulated fibrinogen binding is necessary for some of the inositol phospholipid changes found in ADP-stimulated platelets. Adenosine Diphosphate 102-105 fibrinogen beta chain Homo sapiens 15-25 8396029-1 1993 ADP-stimulation of washed human platelets suspended in Tyrode/albumin solution containing Ca2+ (2 mM) and fibrinogen (0.4 mg/ml) causes extensive, reversible aggregation without appreciable secretion of granule contents. Adenosine Diphosphate 0-3 fibrinogen beta chain Homo sapiens 106-116 8396029-6 1993 These results indicate that the early decreases in PtdInsP2 and PtdInsP at 10 s are dependent on fibrinogen binding to the platelets and occur after fibrinogen binding which is activated by ADP stimulation. phosphatidylinositol 4-phosphate 51-58 fibrinogen beta chain Homo sapiens 97-107 8396029-6 1993 These results indicate that the early decreases in PtdInsP2 and PtdInsP at 10 s are dependent on fibrinogen binding to the platelets and occur after fibrinogen binding which is activated by ADP stimulation. phosphatidylinositol 4-phosphate 51-58 fibrinogen beta chain Homo sapiens 149-159 8396029-6 1993 These results indicate that the early decreases in PtdInsP2 and PtdInsP at 10 s are dependent on fibrinogen binding to the platelets and occur after fibrinogen binding which is activated by ADP stimulation. Adenosine Diphosphate 190-193 fibrinogen beta chain Homo sapiens 97-107 8396029-6 1993 These results indicate that the early decreases in PtdInsP2 and PtdInsP at 10 s are dependent on fibrinogen binding to the platelets and occur after fibrinogen binding which is activated by ADP stimulation. Adenosine Diphosphate 190-193 fibrinogen beta chain Homo sapiens 149-159 10603512-9 1994 Conclusions: These data indicate that the domains for heparin binding may be present on both the gamma chain and the beta chain of fibrinogen, and that the domain on the gamma chain may be close to the binding domain on the carboxy terminus of the fibrinogen gamma chain to glycoprotein IIb-IIIa. Heparin 54-61 fibrinogen beta chain Homo sapiens 248-258 8236124-4 1993 An experiment with ADP-activated, formaldehyde-fixed platelets shows that platelets with activated fibrinogen receptors will bind inactive platelets in the presence of fibrinogen and Ca(2+)-ions. Formaldehyde 34-46 fibrinogen beta chain Homo sapiens 99-109 8236124-4 1993 An experiment with ADP-activated, formaldehyde-fixed platelets shows that platelets with activated fibrinogen receptors will bind inactive platelets in the presence of fibrinogen and Ca(2+)-ions. Formaldehyde 34-46 fibrinogen beta chain Homo sapiens 168-178 8236126-4 1993 After 1 month of therapy, plasma fibrinogen significantly decreased by 9% and 15% in fenofibrate and bezafibrate groups respectively and increased by 19% in gemfibrozil treated patients. Fenofibrate 85-96 fibrinogen beta chain Homo sapiens 33-43 8236126-4 1993 After 1 month of therapy, plasma fibrinogen significantly decreased by 9% and 15% in fenofibrate and bezafibrate groups respectively and increased by 19% in gemfibrozil treated patients. Bezafibrate 101-112 fibrinogen beta chain Homo sapiens 33-43 8236126-4 1993 After 1 month of therapy, plasma fibrinogen significantly decreased by 9% and 15% in fenofibrate and bezafibrate groups respectively and increased by 19% in gemfibrozil treated patients. Gemfibrozil 157-168 fibrinogen beta chain Homo sapiens 33-43 8236126-7 1993 The fibrinogen lowering effect of fenofibrate and bezafibrate does not seem to be related to the hypolipidemic activity of the drugs. Fenofibrate 34-45 fibrinogen beta chain Homo sapiens 4-14 8236126-7 1993 The fibrinogen lowering effect of fenofibrate and bezafibrate does not seem to be related to the hypolipidemic activity of the drugs. Bezafibrate 50-61 fibrinogen beta chain Homo sapiens 4-14 8338001-7 1993 In both groups we determined plasma levels of total cholesterol, triglycerides, and very low-density lipoprotein (VLDL) cholesterol and found these parameters significantly higher in the group with an FG level > 394 mg/dl (p < 0.05). Cholesterol 52-63 fibrinogen beta chain Homo sapiens 201-203 8338001-7 1993 In both groups we determined plasma levels of total cholesterol, triglycerides, and very low-density lipoprotein (VLDL) cholesterol and found these parameters significantly higher in the group with an FG level > 394 mg/dl (p < 0.05). Triglycerides 65-78 fibrinogen beta chain Homo sapiens 201-203 8338001-7 1993 In both groups we determined plasma levels of total cholesterol, triglycerides, and very low-density lipoprotein (VLDL) cholesterol and found these parameters significantly higher in the group with an FG level > 394 mg/dl (p < 0.05). Cholesterol 120-131 fibrinogen beta chain Homo sapiens 201-203 8338688-3 1993 Thrombin-induced coagulation of human fibrinogen (range, 0.04 to 4 mg/ml) in the presence of CLSE (2 mg/ml phospholipids) resulted in progressive loss of surface tension-lowering properties and adsorption facilities of this surfactant preparation; the CLSE-inhibitory capacity of desAABB-fibrin surpassed that of fibrinogen by more than two orders of magnitude. Phospholipids 107-120 fibrinogen beta chain Homo sapiens 38-48 8218849-9 1993 Alcohol drinkers showed reduced platelet activity and have lower levels of fibrinogen, von Willebrand factor and white cell count. Alcohols 0-7 fibrinogen beta chain Homo sapiens 75-85 7503943-3 1993 The monoclonal antibody 3H8 also reacted with fibrinogen in Western blots and in ELISA tests. CHEMBL3355165 24-27 fibrinogen beta chain Homo sapiens 46-56 8393345-2 1993 The dependence of fibrinogen binding to thrombin in the pH range 6-10 is bell-shaped and remarkably similar to that obtained in the case of the small synthetic amide substrate tosyl-Gly-Pro-Arg-p-nitroanilide-AcOH. Amides 160-165 fibrinogen beta chain Homo sapiens 18-28 8236142-6 1993 The breakdown of fibrinogen was related to the quantity of saruplase converted to active two-chain u-PA (tcu-PA) in vivo (6 to 22% conversion). tcu-pa 105-111 fibrinogen beta chain Homo sapiens 17-27 7687438-4 1993 The delay of phosphotyrosine-specific dephosphorylation on those protein bands was observed when thrombin- or STA2-induced aggregation of normal platelets was inhibited by RGDS, an inhibitor of fibrinogen binding to GPIIb-IIIa. Phosphotyrosine 13-28 fibrinogen beta chain Homo sapiens 194-204 7687438-5 1993 These data indicate that fibrinogen binding to GPIIb-IIIa is involved in the regulation of phosphotyrosine-specific dephosphorylation on certain protein bands. Phosphotyrosine 91-106 fibrinogen beta chain Homo sapiens 25-35 8395822-0 1993 Calyculin A inhibits the exposure of fibrinogen receptor in thrombin-stimulated platelets. calyculin A 0-11 fibrinogen beta chain Homo sapiens 37-47 8395822-3 1993 We investigated the effects of CLA on the exposure of fibrinogen receptor in thrombin-stimulated platelets, using flow cytometry with a monoclonal antibody against the fibrinogen receptor of activated glycoprotein(Gp)IIb/IIIa complex (PAC-1). calyculin A 31-34 fibrinogen beta chain Homo sapiens 54-64 8360097-0 1993 Tetrafibricin, a novel fibrinogen receptor antagonist. tetrafibricin 0-13 fibrinogen beta chain Homo sapiens 23-33 8329452-4 1993 Gly-Pro-Arg, which is a known inhibitor of fibrinogen/thrombin clotting, was isolated from the bacterial collagenase hydrolysate of porcine collagen by HPLC. glycyl-prolyl-arginine 0-11 fibrinogen beta chain Homo sapiens 43-53 8401394-0 1993 Alteration of fibrinogen secondary structure by cis-diamminedichloroplatinum(II) and calcium protection. Cisplatin 48-76 fibrinogen beta chain Homo sapiens 14-24 8401394-0 1993 Alteration of fibrinogen secondary structure by cis-diamminedichloroplatinum(II) and calcium protection. Calcium 85-92 fibrinogen beta chain Homo sapiens 14-24 8401394-1 1993 The structural alteration of human fibrinogen (Fbg) by cis-diamminedichloroplatinum(II) (cis-DDP) was investigated using intrinsic fluorescence and circular dichroism (CD) spectra. Cisplatin 55-87 fibrinogen beta chain Homo sapiens 35-45 8401394-1 1993 The structural alteration of human fibrinogen (Fbg) by cis-diamminedichloroplatinum(II) (cis-DDP) was investigated using intrinsic fluorescence and circular dichroism (CD) spectra. Cisplatin 55-87 fibrinogen beta chain Homo sapiens 47-50 8401394-1 1993 The structural alteration of human fibrinogen (Fbg) by cis-diamminedichloroplatinum(II) (cis-DDP) was investigated using intrinsic fluorescence and circular dichroism (CD) spectra. Cisplatin 89-96 fibrinogen beta chain Homo sapiens 35-45 8401394-1 1993 The structural alteration of human fibrinogen (Fbg) by cis-diamminedichloroplatinum(II) (cis-DDP) was investigated using intrinsic fluorescence and circular dichroism (CD) spectra. Cisplatin 89-96 fibrinogen beta chain Homo sapiens 47-50 8401394-2 1993 In a preceding report, incubation of Fbg with cis-DDP under physiological conditions resulted in the cleavage of disulfide (S-S) bonds (N. Ohta, T. Yotsuyanagi and K. Ikeda, J. Cisplatin 46-53 fibrinogen beta chain Homo sapiens 37-40 8401394-2 1993 In a preceding report, incubation of Fbg with cis-DDP under physiological conditions resulted in the cleavage of disulfide (S-S) bonds (N. Ohta, T. Yotsuyanagi and K. Ikeda, J. Disulfides 113-122 fibrinogen beta chain Homo sapiens 37-40 8401394-2 1993 In a preceding report, incubation of Fbg with cis-DDP under physiological conditions resulted in the cleavage of disulfide (S-S) bonds (N. Ohta, T. Yotsuyanagi and K. Ikeda, J. ohta 139-143 fibrinogen beta chain Homo sapiens 37-40 8401394-4 1993 The intensity of fluorescence for cis-DDP-treated Fbg, in which 6.7 S-S bonds per mol of protein were cleaved, was reduced to 42% relative to native Fbg. Cisplatin 34-41 fibrinogen beta chain Homo sapiens 50-53 8401394-4 1993 The intensity of fluorescence for cis-DDP-treated Fbg, in which 6.7 S-S bonds per mol of protein were cleaved, was reduced to 42% relative to native Fbg. Cisplatin 34-41 fibrinogen beta chain Homo sapiens 149-152 8401394-7 1993 The results indicate that cis-DDP leads to a secondary conformational alteration of Fbg involving a structural perturbation of nearby tryptophan residue(s) through S-S bond cleavage. Cisplatin 26-33 fibrinogen beta chain Homo sapiens 84-87 8401394-7 1993 The results indicate that cis-DDP leads to a secondary conformational alteration of Fbg involving a structural perturbation of nearby tryptophan residue(s) through S-S bond cleavage. Tryptophan 134-144 fibrinogen beta chain Homo sapiens 84-87 8401394-8 1993 In a buffer containing calcium, however, the smaller fluorescence quenching and the smaller helix decline were observed in cis-DDP-treated-Fbg, even though the same level of S-S cleavage occurred. Calcium 23-30 fibrinogen beta chain Homo sapiens 139-142 8401394-8 1993 In a buffer containing calcium, however, the smaller fluorescence quenching and the smaller helix decline were observed in cis-DDP-treated-Fbg, even though the same level of S-S cleavage occurred. Cisplatin 123-130 fibrinogen beta chain Homo sapiens 139-142 8401394-9 1993 Calcium binding would protect Fbg in terms of structural alteration as well as S-S cleavage by both dithiothreitol (DTT) and cis-DDP. Calcium 0-7 fibrinogen beta chain Homo sapiens 30-33 8401394-9 1993 Calcium binding would protect Fbg in terms of structural alteration as well as S-S cleavage by both dithiothreitol (DTT) and cis-DDP. Dithiothreitol 116-119 fibrinogen beta chain Homo sapiens 30-33 8401394-9 1993 Calcium binding would protect Fbg in terms of structural alteration as well as S-S cleavage by both dithiothreitol (DTT) and cis-DDP. Cisplatin 125-132 fibrinogen beta chain Homo sapiens 30-33 7686553-3 1993 In this report, we examined whether fibrinogen binding, per se, triggers a process of tyrosine phosphorylation in the absence of exogenous agonists. Tyrosine 86-94 fibrinogen beta chain Homo sapiens 36-46 7686553-5 1993 Proteins of 50-68 KD and 140 kD became phosphorylated on tyrosine residues in a fibrinogen-dependent manner. Tyrosine 57-65 fibrinogen beta chain Homo sapiens 80-90 7686553-7 1993 Tyrosine phosphorylation of the 50-68-kD and 140-kD proteins was also observed when (a) fibrinogen binding was stimulated by agonists such as epinephrine, ADP, or thrombin instead of by anti-LIBS6; (b) fragment X, a dimeric plasmin-derived fragment of fibrinogen was used instead of fibrinogen; or (c) alpha IIb beta 3 complexes were cross-linked by antibodies, even in the absence of fibrinogen. Tyrosine 0-8 fibrinogen beta chain Homo sapiens 88-98 7686553-7 1993 Tyrosine phosphorylation of the 50-68-kD and 140-kD proteins was also observed when (a) fibrinogen binding was stimulated by agonists such as epinephrine, ADP, or thrombin instead of by anti-LIBS6; (b) fragment X, a dimeric plasmin-derived fragment of fibrinogen was used instead of fibrinogen; or (c) alpha IIb beta 3 complexes were cross-linked by antibodies, even in the absence of fibrinogen. Tyrosine 0-8 fibrinogen beta chain Homo sapiens 252-262 7686553-7 1993 Tyrosine phosphorylation of the 50-68-kD and 140-kD proteins was also observed when (a) fibrinogen binding was stimulated by agonists such as epinephrine, ADP, or thrombin instead of by anti-LIBS6; (b) fragment X, a dimeric plasmin-derived fragment of fibrinogen was used instead of fibrinogen; or (c) alpha IIb beta 3 complexes were cross-linked by antibodies, even in the absence of fibrinogen. Tyrosine 0-8 fibrinogen beta chain Homo sapiens 252-262 7686553-7 1993 Tyrosine phosphorylation of the 50-68-kD and 140-kD proteins was also observed when (a) fibrinogen binding was stimulated by agonists such as epinephrine, ADP, or thrombin instead of by anti-LIBS6; (b) fragment X, a dimeric plasmin-derived fragment of fibrinogen was used instead of fibrinogen; or (c) alpha IIb beta 3 complexes were cross-linked by antibodies, even in the absence of fibrinogen. Tyrosine 0-8 fibrinogen beta chain Homo sapiens 252-262 7686553-9 1993 Fibrinogen-dependent tyrosine phosphorylation was inhibited by cytochalasin D. These studies demonstrate that fibrinogen binding to alpha IIb beta 3 initiates a process of tyrosine phosphorylation that precedes platelet aggregation and the phosphorylation of pp125FAK. Tyrosine 21-29 fibrinogen beta chain Homo sapiens 0-10 7686553-9 1993 Fibrinogen-dependent tyrosine phosphorylation was inhibited by cytochalasin D. These studies demonstrate that fibrinogen binding to alpha IIb beta 3 initiates a process of tyrosine phosphorylation that precedes platelet aggregation and the phosphorylation of pp125FAK. Tyrosine 21-29 fibrinogen beta chain Homo sapiens 110-120 7686553-9 1993 Fibrinogen-dependent tyrosine phosphorylation was inhibited by cytochalasin D. These studies demonstrate that fibrinogen binding to alpha IIb beta 3 initiates a process of tyrosine phosphorylation that precedes platelet aggregation and the phosphorylation of pp125FAK. Tyrosine 172-180 fibrinogen beta chain Homo sapiens 0-10 8360097-2 1993 Tetrafibricin is a novel fibrinogen receptor antagonist produced by Streptomyces neyagawaensis NR0577. tetrafibricin 0-13 fibrinogen beta chain Homo sapiens 25-35 7686553-9 1993 Fibrinogen-dependent tyrosine phosphorylation was inhibited by cytochalasin D. These studies demonstrate that fibrinogen binding to alpha IIb beta 3 initiates a process of tyrosine phosphorylation that precedes platelet aggregation and the phosphorylation of pp125FAK. Tyrosine 172-180 fibrinogen beta chain Homo sapiens 110-120 8360097-5 1993 Tetrafibricin strongly inhibited the binding of fibrinogen to its receptors with an IC50 of 46 nM. tetrafibricin 0-13 fibrinogen beta chain Homo sapiens 48-58 8322384-7 1993 At 4 and 8 weeks after the initiation of ticlopidine treatment, the hematocrit value and concentration of fibrinogen were also significantly (P < .05) reduced. Ticlopidine 41-52 fibrinogen beta chain Homo sapiens 106-116 8326289-9 1993 RESULTS: In stepwise regression analysis fibrinogen concentration was found to be correlated to white blood cell count, muscle tension, heart rate, body mass index, age and serum cholesterol concentration in non-smokers, which together explained 14.9% of the variation in fibrinogen concentration. Cholesterol 179-190 fibrinogen beta chain Homo sapiens 41-51 8326289-10 1993 In smokers, platelet count, heart rate, serum triglyceride concentration, age and fasting glucose explained 22.5% of the variation in fibrinogen concentration. Triglycerides 46-58 fibrinogen beta chain Homo sapiens 134-144 8326289-10 1993 In smokers, platelet count, heart rate, serum triglyceride concentration, age and fasting glucose explained 22.5% of the variation in fibrinogen concentration. Glucose 90-97 fibrinogen beta chain Homo sapiens 134-144 8326289-11 1993 The fibrinogen concentration was inversely correlated to the psychological variables, but unrelated to the serum cortisol concentration or to factors connected with the job situation, and it was decreased in moderate alcohol consumers. Alcohols 217-224 fibrinogen beta chain Homo sapiens 4-14 8499399-1 1993 Several epidemiological studies have found that the plasma fibrinogen level is a risk factor for ischemic heart disease (IHD), similar in importance to the serum cholesterol level. Cholesterol 162-173 fibrinogen beta chain Homo sapiens 59-69 8393345-2 1993 The dependence of fibrinogen binding to thrombin in the pH range 6-10 is bell-shaped and remarkably similar to that obtained in the case of the small synthetic amide substrate tosyl-Gly-Pro-Arg-p-nitroanilide-AcOH. tosyl-gly-pro-arg-p-nitroanilide 176-208 fibrinogen beta chain Homo sapiens 18-28 8393345-2 1993 The dependence of fibrinogen binding to thrombin in the pH range 6-10 is bell-shaped and remarkably similar to that obtained in the case of the small synthetic amide substrate tosyl-Gly-Pro-Arg-p-nitroanilide-AcOH. Acetic Acid 209-213 fibrinogen beta chain Homo sapiens 18-28 7686366-6 1993 Occupancy of glycoprotein IIb-IIIa in the membranes with RGD (Arg-Gly-Asp)-containing peptides reversibly exposed neoantigenic epitopes and fibrinogen-binding sites in the receptor. Arginine 62-65 fibrinogen beta chain Homo sapiens 140-150 7686366-6 1993 Occupancy of glycoprotein IIb-IIIa in the membranes with RGD (Arg-Gly-Asp)-containing peptides reversibly exposed neoantigenic epitopes and fibrinogen-binding sites in the receptor. Glycine 66-69 fibrinogen beta chain Homo sapiens 140-150 7686366-6 1993 Occupancy of glycoprotein IIb-IIIa in the membranes with RGD (Arg-Gly-Asp)-containing peptides reversibly exposed neoantigenic epitopes and fibrinogen-binding sites in the receptor. Aspartic Acid 70-73 fibrinogen beta chain Homo sapiens 140-150 8497857-0 1993 Fibrinogen internalization by ADP-stimulated blood platelets. Adenosine Diphosphate 30-33 fibrinogen beta chain Homo sapiens 0-10 8329564-3 1993 ELS was used to study changes in the platelet electrophoretic mobility induced by platelet activation and by fibrinogen binding. N-[(2S,3S,4R)-3,4-dihydroxy-8-oxo-8-[(4-pentylphenyl)amino]-1-{[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}octan-2-yl]hexacosanamide 0-3 fibrinogen beta chain Homo sapiens 109-119 8503855-0 1993 Synthesis of oligopeptide chloromethanes to investigate extended binding regions of proteinases: application to the interaction of fibrinogen with thrombin. Methyl Chloride 26-40 fibrinogen beta chain Homo sapiens 131-141 8257936-0 1993 Recovery of fibrinogen in cryoprecipitate pasteurized in the presence of sucrose and glycine. Sucrose 73-80 fibrinogen beta chain Homo sapiens 12-22 8257936-0 1993 Recovery of fibrinogen in cryoprecipitate pasteurized in the presence of sucrose and glycine. Glycine 85-92 fibrinogen beta chain Homo sapiens 12-22 8257936-1 1993 The effect of sucrose (60% w/w) and 1 M glycine as thermal stabilizers for fibrinogen in cryoprecipitate was studied. Glycine 40-47 fibrinogen beta chain Homo sapiens 75-85 8503273-6 1993 Careful monitoring of fibrinogen is mandatory in patients receiving etoposide and prednisolone. Etoposide 68-77 fibrinogen beta chain Homo sapiens 22-32 8503273-6 1993 Careful monitoring of fibrinogen is mandatory in patients receiving etoposide and prednisolone. Prednisolone 82-94 fibrinogen beta chain Homo sapiens 22-32 8466882-8 1993 Fibrinogen correlated with age in both groups after controlling for testosterone or BMI. Testosterone 68-80 fibrinogen beta chain Homo sapiens 0-10 8499563-8 1993 The binding of r293 clone B cells to fibrinogen required Ca2+ or Mg2+. magnesium ion 65-69 fibrinogen beta chain Homo sapiens 37-47 8491059-12 1993 A highly significant correlation (p < 0.001) was found between phenazone clearance and the prothrombin time, albumin, gamma-globulin, factor V, antithrombin III, fibrinogen and total bilirubin. Antipyrine 66-75 fibrinogen beta chain Homo sapiens 165-175 8314680-2 1993 Heparin-induced Extracorporeal LDL < total cholesterol, triglycerides, fibrinogen > Precipitation (H.E.L.P.) Heparin 0-7 fibrinogen beta chain Homo sapiens 74-84 8473987-4 1993 We have attempted to observe the variations in competitive adsorption of fibrinogen and albumin onto the polyetherurethane urea (PEUU) surface in the presence of external lubricant, such as calcium stearate and silicone fluid coating. polyetherurethane urea 105-127 fibrinogen beta chain Homo sapiens 73-83 8473987-4 1993 We have attempted to observe the variations in competitive adsorption of fibrinogen and albumin onto the polyetherurethane urea (PEUU) surface in the presence of external lubricant, such as calcium stearate and silicone fluid coating. polyetherurethane urea 129-133 fibrinogen beta chain Homo sapiens 73-83 8473987-4 1993 We have attempted to observe the variations in competitive adsorption of fibrinogen and albumin onto the polyetherurethane urea (PEUU) surface in the presence of external lubricant, such as calcium stearate and silicone fluid coating. stearic acid 190-206 fibrinogen beta chain Homo sapiens 73-83 8473987-4 1993 We have attempted to observe the variations in competitive adsorption of fibrinogen and albumin onto the polyetherurethane urea (PEUU) surface in the presence of external lubricant, such as calcium stearate and silicone fluid coating. Silicones 211-219 fibrinogen beta chain Homo sapiens 73-83 8473507-6 1993 Immunoblot analysis of plasma fibrinogen demonstrated that a substantial part of the fibrinogen Dusart molecules were disulfide-linked to albumin. Disulfides 118-127 fibrinogen beta chain Homo sapiens 85-95 8473507-9 1993 These data indicate that the molecular abnormality in fibrinogen Dusart (A alpha 554 Arg-->Cys) results in defective lateral association of the fibrin fibers and disulfide-linked complex formation with albumin, and is associated with a family history of recurrent thrombosis in the affected individuals. Disulfides 162-171 fibrinogen beta chain Homo sapiens 54-64 8479809-6 1993 In a stepwise regression, ponderal index, white blood cell count, and HDL cholesterol showed an independent association with fibrinogen. Cholesterol 74-85 fibrinogen beta chain Homo sapiens 125-135 8054608-3 1993 The model of synchronization of serotonin transport via the membrane of platelets bound into a spongy net by fibrinogen molecules is discussed. Serotonin 32-41 fibrinogen beta chain Homo sapiens 109-119 8344335-3 1993 Using leucine or KIC tracers in dogs, the fractional rate of fibrinogen synthesis was 6.7% or 9.4% lower, respectively, (P < 0.02) using the 3H versus the 14C tracer. Tritium 144-146 fibrinogen beta chain Homo sapiens 61-71 8344335-3 1993 Using leucine or KIC tracers in dogs, the fractional rate of fibrinogen synthesis was 6.7% or 9.4% lower, respectively, (P < 0.02) using the 3H versus the 14C tracer. Carbon-14 158-161 fibrinogen beta chain Homo sapiens 61-71 8361040-1 1993 We previously reported a study on fibrinolysis and fibrinogenolysis that analyzed fragments of fibrin/fibrinogen degradation products (FDP) using sodium dodecyl sulfate-polyacrylamide gel electrophoresis and immunoblotting. Sodium Dodecyl Sulfate 146-168 fibrinogen beta chain Homo sapiens 51-61 8361040-1 1993 We previously reported a study on fibrinolysis and fibrinogenolysis that analyzed fragments of fibrin/fibrinogen degradation products (FDP) using sodium dodecyl sulfate-polyacrylamide gel electrophoresis and immunoblotting. polyacrylamide 169-183 fibrinogen beta chain Homo sapiens 51-61 8340464-1 1993 A high-performance immunoaffinity chromatographic (HPIAC) method for fibrinogen was developed which had several advantages over existing methodologies including increased linear range and no interference from heparin. Heparin 209-216 fibrinogen beta chain Homo sapiens 69-79 8332965-0 1993 The effect of ticlopidine upon plasma fibrinogen levels in patients undergoing suprapubic prostatectomy. Ticlopidine 14-25 fibrinogen beta chain Homo sapiens 38-48 8332965-1 1993 The mechanisms of the antithrombotic effect of the platelet aggregation inhibiting agent Ticlopidine might include a decrease of the plasma fibrinogen level. Ticlopidine 89-100 fibrinogen beta chain Homo sapiens 140-150 8332965-2 1993 The effect of ticlopidine on increased fibrinogen synthesis following trauma, such as surgery, is however not known. Ticlopidine 14-25 fibrinogen beta chain Homo sapiens 39-49 8497857-2 1993 Interaction of gel filtered, ADP-stimulated human platelets with low (0.05 mg/ml) and high (1 mg/ml) fibrinogen (Fg) was examined by transmission electron microscopy. Adenosine Diphosphate 29-32 fibrinogen beta chain Homo sapiens 101-111 8497857-2 1993 Interaction of gel filtered, ADP-stimulated human platelets with low (0.05 mg/ml) and high (1 mg/ml) fibrinogen (Fg) was examined by transmission electron microscopy. Adenosine Diphosphate 29-32 fibrinogen beta chain Homo sapiens 113-115 8497857-13 1993 These results indicate on different ultimate fates of exogenous Fg processed by the ADP-stimulated platelets. Adenosine Diphosphate 84-87 fibrinogen beta chain Homo sapiens 64-66 8434804-6 1993 Urokinase began to enhance the effect of heparin on PTT values as a result of reducing fibrinogen levels. Heparin 41-48 fibrinogen beta chain Homo sapiens 87-97 7682849-4 1993 The results show that pre-adsorption of a hydrophobic cellulose ether with a flocculation temperature < 37 degrees C, on polyurethane and polytetrafluoroethylene, decreased the adsorption of fibrinogen, fibronectin and vitronectin. Cellulose 54-63 fibrinogen beta chain Homo sapiens 194-204 7682849-4 1993 The results show that pre-adsorption of a hydrophobic cellulose ether with a flocculation temperature < 37 degrees C, on polyurethane and polytetrafluoroethylene, decreased the adsorption of fibrinogen, fibronectin and vitronectin. Polyurethanes 124-136 fibrinogen beta chain Homo sapiens 194-204 7682849-4 1993 The results show that pre-adsorption of a hydrophobic cellulose ether with a flocculation temperature < 37 degrees C, on polyurethane and polytetrafluoroethylene, decreased the adsorption of fibrinogen, fibronectin and vitronectin. Polytetrafluoroethylene 141-164 fibrinogen beta chain Homo sapiens 194-204 8384496-2 1993 Urinary PCI bound to fibrin(ogen)-Sepharose in a heparin-dependent manner at a level about 1.6-fold higher to fibrin-Sepharose than to fibrinogen-Sepharose. Sepharose 34-43 fibrinogen beta chain Homo sapiens 135-145 8384496-3 1993 Scatchard analysis of the binding between urinary PCI and fibrin(ogen)-Sepharose showed that the Kd for fibrin-Sepharose and fibrinogen-Sepharose were 4.0 nM and 5.7 nM respectively. Sepharose 71-80 fibrinogen beta chain Homo sapiens 125-135 8457644-0 1993 Incubation of monocytes with adriamycin increases secretion of hepatocyte stimulating factor for fibrinogen biosynthesis. Doxorubicin 29-39 fibrinogen beta chain Homo sapiens 97-107 8457644-1 1993 This work provides evidence that the production by monocytes of hepatocyte stimulating factor(s) for fibrinogen biosynthesis was dramatically increased when monocytes were exposed to Adriamycin. Doxorubicin 183-193 fibrinogen beta chain Homo sapiens 101-111 8457652-10 1993 These clones secreted biologically active recombinant human fibrinogen, which was purified from serum-free culture media by protamine-Sepharose chromatography. Sepharose 134-143 fibrinogen beta chain Homo sapiens 60-70 8457658-7 1993 Fibrinogen and all but low molecular weight degradation products can be specifically precipitated within electrophoregrams by heat denaturation at 47 degrees C. After washing unrelated protein away, the fibrin(ogen) derivatives can be measured by staining with Coomassie blue. Coomassie blue 261-275 fibrinogen beta chain Homo sapiens 0-10 8383563-7 1993 The NK2 selective antagonist, SR 48968, caused a dose-dependent inhibition of NKA and [beta-Ala8]NKA(4-10)-induced extravasation of fibrinogen in guinea-pig secondary bronchi and intraparenchymal airways. SR 48968 30-38 fibrinogen beta chain Homo sapiens 132-142 8383563-7 1993 The NK2 selective antagonist, SR 48968, caused a dose-dependent inhibition of NKA and [beta-Ala8]NKA(4-10)-induced extravasation of fibrinogen in guinea-pig secondary bronchi and intraparenchymal airways. beta-ala8 87-96 fibrinogen beta chain Homo sapiens 132-142 8457474-0 1993 UVB radiation exposes fibrinogen binding sites on platelets by activating protein kinase C via reactive oxygen species. Reactive Oxygen Species 95-118 fibrinogen beta chain Homo sapiens 22-32 8457474-7 1993 We conclude that exposure of platelets to UVB radiation can activate PK-C via oxygen radicals, resulting in exposure of fibrinogen binding sites and subsequent platelet aggregation. Reactive Oxygen Species 78-93 fibrinogen beta chain Homo sapiens 120-130 8427591-0 1993 The role of amino-terminal disulfide bonds in the structure and assembly of human fibrinogen. Disulfides 27-36 fibrinogen beta chain Homo sapiens 82-92 8427591-1 1993 Human fibrinogen contains two half-molecules, each composed of an alpha, beta, and gamma chain linked by disulfide bonds. Disulfides 105-114 fibrinogen beta chain Homo sapiens 6-16 8427591-4 1993 An analysis of the fibrinogen synthesized in transfected baby hamster kidney (BHK) cells employing various combinations of these mutations revealed that alpha-Cys36 and beta-Cys65 form disulfide bonds between two alpha beta gamma half-molecules, rather than within the same half-molecule; furthermore, these two disulfide bonds are sufficient to hold the two alpha beta gamma half-molecules together as intact fibrinogen. alpha-cys36 153-164 fibrinogen beta chain Homo sapiens 19-29 8427591-4 1993 An analysis of the fibrinogen synthesized in transfected baby hamster kidney (BHK) cells employing various combinations of these mutations revealed that alpha-Cys36 and beta-Cys65 form disulfide bonds between two alpha beta gamma half-molecules, rather than within the same half-molecule; furthermore, these two disulfide bonds are sufficient to hold the two alpha beta gamma half-molecules together as intact fibrinogen. alpha-cys36 153-164 fibrinogen beta chain Homo sapiens 410-420 8427591-4 1993 An analysis of the fibrinogen synthesized in transfected baby hamster kidney (BHK) cells employing various combinations of these mutations revealed that alpha-Cys36 and beta-Cys65 form disulfide bonds between two alpha beta gamma half-molecules, rather than within the same half-molecule; furthermore, these two disulfide bonds are sufficient to hold the two alpha beta gamma half-molecules together as intact fibrinogen. beta-cys65 169-179 fibrinogen beta chain Homo sapiens 19-29 8427591-4 1993 An analysis of the fibrinogen synthesized in transfected baby hamster kidney (BHK) cells employing various combinations of these mutations revealed that alpha-Cys36 and beta-Cys65 form disulfide bonds between two alpha beta gamma half-molecules, rather than within the same half-molecule; furthermore, these two disulfide bonds are sufficient to hold the two alpha beta gamma half-molecules together as intact fibrinogen. beta-cys65 169-179 fibrinogen beta chain Homo sapiens 410-420 8427591-4 1993 An analysis of the fibrinogen synthesized in transfected baby hamster kidney (BHK) cells employing various combinations of these mutations revealed that alpha-Cys36 and beta-Cys65 form disulfide bonds between two alpha beta gamma half-molecules, rather than within the same half-molecule; furthermore, these two disulfide bonds are sufficient to hold the two alpha beta gamma half-molecules together as intact fibrinogen. Disulfides 185-194 fibrinogen beta chain Homo sapiens 19-29 8427591-5 1993 Disulfide bonds formed by gamma-Cys8 and 9 were also sufficient to hold the two fibrinogen alpha beta gamma half-molecules together, while the disulfide bond between the two alpha-Cys28 residues failed to form in the absence of the disulfide bonds linking the alpha and beta chains and the two gamma chains. Disulfides 0-9 fibrinogen beta chain Homo sapiens 80-90 8427591-5 1993 Disulfide bonds formed by gamma-Cys8 and 9 were also sufficient to hold the two fibrinogen alpha beta gamma half-molecules together, while the disulfide bond between the two alpha-Cys28 residues failed to form in the absence of the disulfide bonds linking the alpha and beta chains and the two gamma chains. gamma-cys8 26-36 fibrinogen beta chain Homo sapiens 80-90 8424682-3 1993 The Km for single-chain wild-type (wt) r-tPA toward the synthetic substrate H-D-Ile-L-Pro-L-Arg-p-nitroanilide (S2288) was decreased by approximately 3-fold in the presence of a saturating concentration of human fibrinogen (Fg), along with a small (1.14-fold) increase in the kcat for this same reaction. r-tpa 39-44 fibrinogen beta chain Homo sapiens 212-222 7688529-1 1993 Methylmercuric chloride (MMC) in concentrations 0.1-10 microM reduces the amount of fibrinopeptides released from thrombin-activated human fibrinogen. methylmercuric chloride 0-23 fibrinogen beta chain Homo sapiens 139-149 7688529-1 1993 Methylmercuric chloride (MMC) in concentrations 0.1-10 microM reduces the amount of fibrinopeptides released from thrombin-activated human fibrinogen. methylmercuric chloride 25-28 fibrinogen beta chain Homo sapiens 139-149 8424460-9 1993 When fibrinogen was clotted in Dulbecco"s modified Eagle"s medium, gamma-chains were cross-linked, but alpha-chain cross-linking was strikingly inhibited, and fibroblasts migrated poorly. dulbecco"s modified eagle"s medium 31-65 fibrinogen beta chain Homo sapiens 5-15 8418764-2 1993 Plasma fibrinogen concentration appears to be an important risk factor for the development of atherosclerotic cardiovascular disease of a similar magnitude to cholesterol. Cholesterol 159-170 fibrinogen beta chain Homo sapiens 7-17 7507391-10 1993 Determination of the binding of two radiolabeled probes directed against the fibrinogen receptor, fibrinogen itself, and a monoclonal antibody (M.Ab.G10) revealed that the binding of fibrinogen to ADP-stimulated platelets was enhanced by 50% following the preincubation of platelets with 600 ng/ml CSA. Adenosine Diphosphate 197-200 fibrinogen beta chain Homo sapiens 77-87 7507391-10 1993 Determination of the binding of two radiolabeled probes directed against the fibrinogen receptor, fibrinogen itself, and a monoclonal antibody (M.Ab.G10) revealed that the binding of fibrinogen to ADP-stimulated platelets was enhanced by 50% following the preincubation of platelets with 600 ng/ml CSA. Adenosine Diphosphate 197-200 fibrinogen beta chain Homo sapiens 98-108 7507391-10 1993 Determination of the binding of two radiolabeled probes directed against the fibrinogen receptor, fibrinogen itself, and a monoclonal antibody (M.Ab.G10) revealed that the binding of fibrinogen to ADP-stimulated platelets was enhanced by 50% following the preincubation of platelets with 600 ng/ml CSA. Adenosine Diphosphate 197-200 fibrinogen beta chain Homo sapiens 98-108 8241058-0 1993 Adsorption behavior of fibrinogen to sulfonated polyethyleneoxide-grafted polyurethane surfaces. Polyethylene Glycols 48-65 fibrinogen beta chain Homo sapiens 23-33 8241058-0 1993 Adsorption behavior of fibrinogen to sulfonated polyethyleneoxide-grafted polyurethane surfaces. Polyurethanes 74-86 fibrinogen beta chain Homo sapiens 23-33 8241058-1 1993 Fibrinogen adsorptions to surface modified polyurethanes (PU, PU-PEO, and PU-PEO-SO3) were studied from plasma in vitro. Polyurethanes 43-56 fibrinogen beta chain Homo sapiens 0-10 8424682-3 1993 The Km for single-chain wild-type (wt) r-tPA toward the synthetic substrate H-D-Ile-L-Pro-L-Arg-p-nitroanilide (S2288) was decreased by approximately 3-fold in the presence of a saturating concentration of human fibrinogen (Fg), along with a small (1.14-fold) increase in the kcat for this same reaction. h-d-ile-l-pro-l-arg-p-nitroanilide 76-110 fibrinogen beta chain Homo sapiens 212-222 8241058-1 1993 Fibrinogen adsorptions to surface modified polyurethanes (PU, PU-PEO, and PU-PEO-SO3) were studied from plasma in vitro. Polyurethanes 58-60 fibrinogen beta chain Homo sapiens 0-10 8241058-1 1993 Fibrinogen adsorptions to surface modified polyurethanes (PU, PU-PEO, and PU-PEO-SO3) were studied from plasma in vitro. pu-peo 62-68 fibrinogen beta chain Homo sapiens 0-10 8241058-3 1993 In contrast, PU-PEO-SO3 showed that initial adsorption is almost same regardless of plasma concentration and adsorption time, which is due to the high affinity of surface sulfonate group to fibrinogen. pu-peo-so3 13-23 fibrinogen beta chain Homo sapiens 190-200 8424687-7 1993 Moreover, both the 33-kDa and the 40-kDa proteins inhibited fibrinogen binding (at 0.1 microM) to ADP- or thrombin-stimulated platelets with IC50 values in the same concentration range. Adenosine Diphosphate 98-101 fibrinogen beta chain Homo sapiens 60-70 8241058-3 1993 In contrast, PU-PEO-SO3 showed that initial adsorption is almost same regardless of plasma concentration and adsorption time, which is due to the high affinity of surface sulfonate group to fibrinogen. sulfonate 171-180 fibrinogen beta chain Homo sapiens 190-200 8426076-3 1993 This study examined the effect of Mn+2 on fibrinogen interactions with intact platelets. mn+2 34-38 fibrinogen beta chain Homo sapiens 42-52 8423218-0 1993 Kistrin, an integrin antagonist, blocks endocytosis of fibrinogen into guinea pig megakaryocyte and platelet alpha-granules. kistrin 0-7 fibrinogen beta chain Homo sapiens 55-65 8423218-4 1993 To test this hypothesis, we examined the effect of Kistrin, an RGD-containing protein purified from the venom of Agkistrodon rhodostoma that inhibits fibrinogen binding to human platelet receptors, on endocytosis of fibrinogen by megakaryocytes and platelets. kistrin 51-58 fibrinogen beta chain Homo sapiens 150-160 8423218-6 1993 When biotinylated fibrinogen was injected intravenously into animals receiving Kistrin, megakaryocytes failed to endocytose the labeled fibrinogen. kistrin 79-86 fibrinogen beta chain Homo sapiens 18-28 8426076-4 1993 Compared with that of control platelets in buffer containing 1 mmol/L Mg+2, fibrinogen binding to adenosine diphosphate- or thrombin-stimulated platelets decreased 23% +/- 12% and 15% +/- 9% (mean +/- SD, n = 4), respectively, after addition of 1 mmol/L Mn+2. Adenosine Diphosphate 98-119 fibrinogen beta chain Homo sapiens 76-86 8426076-6 1993 Ethylenediaminetetraacetic acid dissociated 68% +/- 8% of fibrinogen bound to ADP-treated platelets (p < 0.05) during a 60-minute incubation with fibrinogen and 1 mmol/L Mn+2, compared with 40% +/- 13% of fibrinogen bound to control platelets and 29% +/- 8% of fibrinogen bound in the presence of Ca+2 (mean +/- SD, n = 6). Edetic Acid 0-31 fibrinogen beta chain Homo sapiens 58-68 8426076-6 1993 Ethylenediaminetetraacetic acid dissociated 68% +/- 8% of fibrinogen bound to ADP-treated platelets (p < 0.05) during a 60-minute incubation with fibrinogen and 1 mmol/L Mn+2, compared with 40% +/- 13% of fibrinogen bound to control platelets and 29% +/- 8% of fibrinogen bound in the presence of Ca+2 (mean +/- SD, n = 6). Edetic Acid 0-31 fibrinogen beta chain Homo sapiens 149-159 8426076-6 1993 Ethylenediaminetetraacetic acid dissociated 68% +/- 8% of fibrinogen bound to ADP-treated platelets (p < 0.05) during a 60-minute incubation with fibrinogen and 1 mmol/L Mn+2, compared with 40% +/- 13% of fibrinogen bound to control platelets and 29% +/- 8% of fibrinogen bound in the presence of Ca+2 (mean +/- SD, n = 6). Edetic Acid 0-31 fibrinogen beta chain Homo sapiens 149-159 8426076-6 1993 Ethylenediaminetetraacetic acid dissociated 68% +/- 8% of fibrinogen bound to ADP-treated platelets (p < 0.05) during a 60-minute incubation with fibrinogen and 1 mmol/L Mn+2, compared with 40% +/- 13% of fibrinogen bound to control platelets and 29% +/- 8% of fibrinogen bound in the presence of Ca+2 (mean +/- SD, n = 6). Edetic Acid 0-31 fibrinogen beta chain Homo sapiens 149-159 8426076-6 1993 Ethylenediaminetetraacetic acid dissociated 68% +/- 8% of fibrinogen bound to ADP-treated platelets (p < 0.05) during a 60-minute incubation with fibrinogen and 1 mmol/L Mn+2, compared with 40% +/- 13% of fibrinogen bound to control platelets and 29% +/- 8% of fibrinogen bound in the presence of Ca+2 (mean +/- SD, n = 6). Adenosine Diphosphate 78-81 fibrinogen beta chain Homo sapiens 58-68 8426076-6 1993 Ethylenediaminetetraacetic acid dissociated 68% +/- 8% of fibrinogen bound to ADP-treated platelets (p < 0.05) during a 60-minute incubation with fibrinogen and 1 mmol/L Mn+2, compared with 40% +/- 13% of fibrinogen bound to control platelets and 29% +/- 8% of fibrinogen bound in the presence of Ca+2 (mean +/- SD, n = 6). Adenosine Diphosphate 78-81 fibrinogen beta chain Homo sapiens 149-159 8426076-6 1993 Ethylenediaminetetraacetic acid dissociated 68% +/- 8% of fibrinogen bound to ADP-treated platelets (p < 0.05) during a 60-minute incubation with fibrinogen and 1 mmol/L Mn+2, compared with 40% +/- 13% of fibrinogen bound to control platelets and 29% +/- 8% of fibrinogen bound in the presence of Ca+2 (mean +/- SD, n = 6). Adenosine Diphosphate 78-81 fibrinogen beta chain Homo sapiens 149-159 8426076-6 1993 Ethylenediaminetetraacetic acid dissociated 68% +/- 8% of fibrinogen bound to ADP-treated platelets (p < 0.05) during a 60-minute incubation with fibrinogen and 1 mmol/L Mn+2, compared with 40% +/- 13% of fibrinogen bound to control platelets and 29% +/- 8% of fibrinogen bound in the presence of Ca+2 (mean +/- SD, n = 6). Adenosine Diphosphate 78-81 fibrinogen beta chain Homo sapiens 149-159 8426076-7 1993 Mn+2 also diminished the stabilization of fibrinogen interaction with thrombin-stimulated platelets and inhibited the recovery of bound fibrinogen with the Triton X-100 (Union Carbide Corp., Danbury, Conn.) insoluble cytoskeleton. mn+2 0-4 fibrinogen beta chain Homo sapiens 42-52 8426076-7 1993 Mn+2 also diminished the stabilization of fibrinogen interaction with thrombin-stimulated platelets and inhibited the recovery of bound fibrinogen with the Triton X-100 (Union Carbide Corp., Danbury, Conn.) insoluble cytoskeleton. mn+2 0-4 fibrinogen beta chain Homo sapiens 136-146 8426076-7 1993 Mn+2 also diminished the stabilization of fibrinogen interaction with thrombin-stimulated platelets and inhibited the recovery of bound fibrinogen with the Triton X-100 (Union Carbide Corp., Danbury, Conn.) insoluble cytoskeleton. Octoxynol 156-168 fibrinogen beta chain Homo sapiens 136-146 8426076-8 1993 Only 31% +/- 10% of fibrinogen bound to thrombin-stimulated platelets for 60 minutes in the presence of Mn+2 associated with the cytoskeleton (p < 0.05), compared with 61% +/- 14% and 75% +/- 20% of fibrinogen bound to control platelets incubated with and without Ca+2, respectively. mn+2 104-108 fibrinogen beta chain Homo sapiens 20-30 8303598-5 1993 ADP-induced platelet aggregation, blood fibrinogen levels got reduced. Adenosine Diphosphate 0-3 fibrinogen beta chain Homo sapiens 40-50 8121125-5 1993 Fibrinogen level increased from 3.34 +/- 0.15 to 3.95 +/- 0.18 g/l, p < 0.001, and from 3.36 +/- 0.17 to 3.94 +/- 0.17 g/l p = 0.003 in aspirin and heparin groups, respectively. Aspirin 139-146 fibrinogen beta chain Homo sapiens 0-10 8121125-5 1993 Fibrinogen level increased from 3.34 +/- 0.15 to 3.95 +/- 0.18 g/l, p < 0.001, and from 3.36 +/- 0.17 to 3.94 +/- 0.17 g/l p = 0.003 in aspirin and heparin groups, respectively. Heparin 151-158 fibrinogen beta chain Homo sapiens 0-10 8333205-3 1993 By applying heparin-induced extracorporeal LDL < cholesterol, triglycerides, fibrinogen > precipitation (H.E.L.P. Heparin 12-19 fibrinogen beta chain Homo sapiens 80-90 8367976-2 1993 To evaluate the association between fibrinogen and blood sedimentation rate (BSR) 40 patients suffering from cerebral multi-infarct disease underwent a single heparin-induced extracorporeal LDL < fibrinogen > precipitation (HELP). Heparin 159-166 fibrinogen beta chain Homo sapiens 199-209 1479591-0 1992 Potent inhibitors of platelet aggregation based upon the Arg-Gly-Asp-Phe sequence of fibrinogen. Arginine 57-60 fibrinogen beta chain Homo sapiens 85-95 1479591-0 1992 Potent inhibitors of platelet aggregation based upon the Arg-Gly-Asp-Phe sequence of fibrinogen. Glycine 61-64 fibrinogen beta chain Homo sapiens 85-95 1479591-0 1992 Potent inhibitors of platelet aggregation based upon the Arg-Gly-Asp-Phe sequence of fibrinogen. Aspartic Acid 65-68 fibrinogen beta chain Homo sapiens 85-95 1479591-0 1992 Potent inhibitors of platelet aggregation based upon the Arg-Gly-Asp-Phe sequence of fibrinogen. Phenylalanine 69-72 fibrinogen beta chain Homo sapiens 85-95 1341057-0 1992 Increased phosphate content of fibrinogen in vivo correlates with alteration in fibrinogen behaviour. Phosphates 10-19 fibrinogen beta chain Homo sapiens 31-41 1341057-0 1992 Increased phosphate content of fibrinogen in vivo correlates with alteration in fibrinogen behaviour. Phosphates 10-19 fibrinogen beta chain Homo sapiens 80-90 1332957-3 1992 The consensus 15-mer oligonucleotide inhibited both fibrinogen-clotting and platelet-activation activities of plasma-derived thrombin, recombinant wild type thrombin, and mutant thrombin K154A in a sequence-specific and dose-dependent manner, whereas it did not inhibit either activity of mutant thrombin R70E. Oligonucleotides 21-36 fibrinogen beta chain Homo sapiens 52-62 1332957-6 1992 These results suggest that Arg-70 in the anion-binding exosite of thrombin is a key determinant for interaction with specific single-stranded DNA molecules, and that binding of single-stranded DNA molecules to the exosite prevents the interaction of thrombin with fibrinogen, the platelet thrombin receptor, and thrombomodulin. Arginine 27-30 fibrinogen beta chain Homo sapiens 264-274 1302622-0 1992 Tetranucleotide repeat polymorphism at the human alpha fibrinogen locus (FGA). tetranucleotide 0-15 fibrinogen beta chain Homo sapiens 55-65 1447186-1 1992 Heparin, in Langmuirian fashion, binds stoichiometrically with high affinity, Kd approximately 100 nM, to both fibrinogen and fibrin adsorbed as monomolecular films to lecithin-coated, microscopic, polystyrene-divinylbenzene beads. Heparin 0-7 fibrinogen beta chain Homo sapiens 111-121 1454798-0 1992 Fibrinogen blocks the autoactivation and thrombin-mediated activation of factor XI on dextran sulfate. Dextran Sulfate 86-101 fibrinogen beta chain Homo sapiens 0-10 1484067-0 1992 Changes in fibrinogen adsorbed to segmented polyurethanes and hydroxyethylmethacrylate-ethylmethacrylate copolymers. Polyurethanes 44-57 fibrinogen beta chain Homo sapiens 11-21 1484067-0 1992 Changes in fibrinogen adsorbed to segmented polyurethanes and hydroxyethylmethacrylate-ethylmethacrylate copolymers. hydroxyethyl methacrylate-ethyl methacrylate 62-115 fibrinogen beta chain Homo sapiens 11-21 1484067-3 1992 In this study fibrinogen adsorption to several polymers was examined to ascertain the influence of controlled changes in surface chemistry on the Vroman effect. Polymers 47-55 fibrinogen beta chain Homo sapiens 14-24 1484067-9 1992 The more hydrophobic polymers exhibited greater retention of adsorbed fibrinogen. Polymers 21-29 fibrinogen beta chain Homo sapiens 70-80 1484067-10 1992 In addition, the fraction of fibrinogen retained by polyethylene depended on the amount of fibrinogen adsorbed to the surface, being greatest when the surface loading was the least. Polyethylene 52-64 fibrinogen beta chain Homo sapiens 29-39 1484067-10 1992 In addition, the fraction of fibrinogen retained by polyethylene depended on the amount of fibrinogen adsorbed to the surface, being greatest when the surface loading was the least. Polyethylene 52-64 fibrinogen beta chain Homo sapiens 91-101 1484068-0 1992 Interactions of thermally denatured fibrinogen on polyethylene with plasma proteins and platelets. Polyethylene 50-62 fibrinogen beta chain Homo sapiens 36-46 1484068-1 1992 During the investigation of fibrin deposition onto hydrophobic polymers in contact with human blood, a model was developed in which fibrinogen was denatured and irreversibly coated onto a polyethylene surface by heating to 70 degrees C for 10 min. Polyethylene 188-200 fibrinogen beta chain Homo sapiens 132-142 1484068-2 1992 The denatured fibrinogen-polyethylene surface is resistant to fluid wall shear rates of up to 550 s-1 and the fibrinogen does not desorb in the presence of plasma proteins. Polyethylene 25-37 fibrinogen beta chain Homo sapiens 14-24 1484068-2 1992 The denatured fibrinogen-polyethylene surface is resistant to fluid wall shear rates of up to 550 s-1 and the fibrinogen does not desorb in the presence of plasma proteins. Polyethylene 25-37 fibrinogen beta chain Homo sapiens 110-120 1484068-3 1992 Compared to uncoated polyethylene, little albumin or fibrinogen adsorbs to heat-denatured fibrinogen. Polyethylene 21-33 fibrinogen beta chain Homo sapiens 90-100 1484068-4 1992 Thrombin binds to the denatured fibrinogen-coated polyethylene with low affinity and also acts on the surface-bound denatured fibrinogen and cleaves fibrinopeptide A (FPA) quantitatively. Polyethylene 50-62 fibrinogen beta chain Homo sapiens 32-42 1304901-0 1992 The synthetic peptide Gly-Pro-Arg-Pro-amide limits the plasmic digestion of fibrinogen in the same fashion as calcium ion. gly-pro-arg-pro-amide 22-43 fibrinogen beta chain Homo sapiens 76-86 1445891-1 1992 The kinetic mechanism of thrombin-fibrinogen interaction has been elucidated by steady-state measurements of synthetic substrate hydrolysis by human alpha-thrombin in the presence of human fibrinogen used as a competitive inhibitor and sucrose used as a viscogenic agent. Sucrose 236-243 fibrinogen beta chain Homo sapiens 34-44 1445891-2 1992 Sucrose greatly affects the FKm for thrombin-fibrinogen interaction, without altering the intrinsic properties of the system. Sucrose 0-7 fibrinogen beta chain Homo sapiens 45-55 1445891-3 1992 Under conditions of pH 7.5 and 0.1 M NaCl, fibrinogen behaves like a sticky substrate for thrombin, with acylation being comparable to dissociation in the temperature range 20-37 degrees C. In the same temperature range, deacylation is much faster than acylation. Sodium Chloride 37-41 fibrinogen beta chain Homo sapiens 43-53 1447740-1 1992 The tetrapeptide H-Arg-Gly-Asp-Ser-OH (1) (RGDS), representing a recognition sequence of fibrinogen for its platelet receptor GP IIb-IIIa (integrin alpha IIb beta 3), served as lead compound for the development of highly potent and selective fibrinogen receptor antagonists. h-arg-gly-asp-ser-oh ( 17-39 fibrinogen beta chain Homo sapiens 89-99 1447740-1 1992 The tetrapeptide H-Arg-Gly-Asp-Ser-OH (1) (RGDS), representing a recognition sequence of fibrinogen for its platelet receptor GP IIb-IIIa (integrin alpha IIb beta 3), served as lead compound for the development of highly potent and selective fibrinogen receptor antagonists. h-arg-gly-asp-ser-oh ( 17-39 fibrinogen beta chain Homo sapiens 242-252 1447740-3 1992 By random screening [(p-amidinobenzenesulfonamido)ethyl]-p-phenoxyacetic acid derivatives have been identified as fibrinogen receptor antagonists. [(p-amidinobenzenesulfonamido)ethyl]-p-phenoxyacetic acid 20-77 fibrinogen beta chain Homo sapiens 114-124 1289495-1 1992 Disulfide bridges in fibrinogen (Fbg) were cleaved by cis-diamminedichloroplatinum(II) (cis-DDP). Cisplatin 88-95 fibrinogen beta chain Homo sapiens 33-36 1438206-7 1992 However, isolated alpha IIb beta 3 was able to bind to an Arg-Gly-Asp-Ser affinity column, and binding of soluble fibrinogen to the patient"s platelets could be triggered by modulators of alpha IIb beta 3 conformation such as the Arg-Gly-Asp-Ser peptide and alpha-chymotrypsin. arginyl-glycyl-aspartyl-serine 230-245 fibrinogen beta chain Homo sapiens 114-124 1333636-1 1992 In plasma from healthy subjects a coupling was identified between von Willebrand factor (vWf), fibrinogen (fg), and fibronectin (fn) that was dependent of anticoagulants heparin, EDTA, and citrate. Heparin 170-177 fibrinogen beta chain Homo sapiens 95-105 1333636-1 1992 In plasma from healthy subjects a coupling was identified between von Willebrand factor (vWf), fibrinogen (fg), and fibronectin (fn) that was dependent of anticoagulants heparin, EDTA, and citrate. Edetic Acid 179-183 fibrinogen beta chain Homo sapiens 95-105 1333636-1 1992 In plasma from healthy subjects a coupling was identified between von Willebrand factor (vWf), fibrinogen (fg), and fibronectin (fn) that was dependent of anticoagulants heparin, EDTA, and citrate. Citric Acid 189-196 fibrinogen beta chain Homo sapiens 95-105 1419616-3 1992 There was an initial reduction in fibrinogen levels in all women on tamoxifen over the first year of follow-up and a marginal reduction in antithrombin III and Protein S in postmenopausal women at 6 months. Tamoxifen 68-77 fibrinogen beta chain Homo sapiens 34-44 1331349-2 1992 Preoperative hemostatic data were obtained on 42 brain tumor patients and correlated with the subsequent occurrence of venous thrombosis detected with 125I-labeled fibrinogen leg scans. Iodine-125 151-155 fibrinogen beta chain Homo sapiens 164-174 8241058-6 1993 The adsorption behavior of PU-PEO-SO3 is attributed to both effect of low binding affinity of PEO chain and high affinity of pendant sulfonate group toward fibrinogen. pu-peo-so3 27-37 fibrinogen beta chain Homo sapiens 156-166 8241058-6 1993 The adsorption behavior of PU-PEO-SO3 is attributed to both effect of low binding affinity of PEO chain and high affinity of pendant sulfonate group toward fibrinogen. sulfonate 133-142 fibrinogen beta chain Homo sapiens 156-166 8280673-9 1993 Cellulose showed very low adsorption of fibrinogen from plasma. Cellulose 0-9 fibrinogen beta chain Homo sapiens 40-50 1455400-4 1992 Analysis of fibrinogen chains on sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) in the system of Laemmli only revealed the presence of abnormal gamma-chain with an apparently higher molecular weight, the presence of which was more clearly detected with SDS-PAGE of fibrin monomer obtained by thrombin treatment. Sodium Dodecyl Sulfate 33-55 fibrinogen beta chain Homo sapiens 12-22 1455400-4 1992 Analysis of fibrinogen chains on sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) in the system of Laemmli only revealed the presence of abnormal gamma-chain with an apparently higher molecular weight, the presence of which was more clearly detected with SDS-PAGE of fibrin monomer obtained by thrombin treatment. polyacrylamide 56-70 fibrinogen beta chain Homo sapiens 12-22 1455400-4 1992 Analysis of fibrinogen chains on sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) in the system of Laemmli only revealed the presence of abnormal gamma-chain with an apparently higher molecular weight, the presence of which was more clearly detected with SDS-PAGE of fibrin monomer obtained by thrombin treatment. Sodium Dodecyl Sulfate 92-95 fibrinogen beta chain Homo sapiens 12-22 1455400-5 1992 Purified fragment D1 of fibrinogen Osaka III also seemed to contain an apparently higher molecular weight fragment D1 gamma remnant on Laemmli gels, which was digested faster than the normal control by plasmin in the presence of [ethylenebis(oxyethylenenitrilo)]tetraacetic acid (EGTA). Egtazic Acid 230-278 fibrinogen beta chain Homo sapiens 24-34 1455400-5 1992 Purified fragment D1 of fibrinogen Osaka III also seemed to contain an apparently higher molecular weight fragment D1 gamma remnant on Laemmli gels, which was digested faster than the normal control by plasmin in the presence of [ethylenebis(oxyethylenenitrilo)]tetraacetic acid (EGTA). Egtazic Acid 280-284 fibrinogen beta chain Homo sapiens 24-34 1442974-6 1992 Fibrinogen antigen was significantly increased for norethindrone plus ethinyl estradiol after 6 and 12 months and for levonorgestrel plus ethinyl estradiol after 12 months. Norethindrone 51-64 fibrinogen beta chain Homo sapiens 0-10 1442974-6 1992 Fibrinogen antigen was significantly increased for norethindrone plus ethinyl estradiol after 6 and 12 months and for levonorgestrel plus ethinyl estradiol after 12 months. Ethinyl Estradiol 70-87 fibrinogen beta chain Homo sapiens 0-10 1442974-6 1992 Fibrinogen antigen was significantly increased for norethindrone plus ethinyl estradiol after 6 and 12 months and for levonorgestrel plus ethinyl estradiol after 12 months. Levonorgestrel 118-132 fibrinogen beta chain Homo sapiens 0-10 1442974-6 1992 Fibrinogen antigen was significantly increased for norethindrone plus ethinyl estradiol after 6 and 12 months and for levonorgestrel plus ethinyl estradiol after 12 months. Ethinyl Estradiol 138-155 fibrinogen beta chain Homo sapiens 0-10 1489846-2 1992 The data presented here describe the baseline measurements of fibrinogen in 1008 apparently healthy subjects, aged 4-60 years and their relationship to age, sex, body weight, smoking, alcohol, and use of oral contraceptives. Alcohols 184-191 fibrinogen beta chain Homo sapiens 62-72 1489846-11 1992 Each cigarette smoked per day increases of the mean fibrinogen by 0.35 g/l after standardization for ponderal index and alcohol consumption. Alcohols 120-127 fibrinogen beta chain Homo sapiens 52-62 1489846-12 1992 Alcohol consumption was negatively correlated to plasma fibrinogen in subjects 30-40 years old. Alcohols 0-7 fibrinogen beta chain Homo sapiens 56-66 1489846-13 1992 In women, 1 g of alcohol per day induces a 0.008 g/l decrease in the mean fibrinogen while in men the decrease is 0.004 g/l. Alcohols 17-24 fibrinogen beta chain Homo sapiens 74-84 1385445-6 1992 These results indicate that tyrosine phosphorylation of pp125FAK is dependent on platelet aggregation mediated by fibrinogen binding to the integrin receptor GP IIb-IIIa. Tyrosine 28-36 fibrinogen beta chain Homo sapiens 114-124 1431204-4 1992 EDTA is known to induce an irreversible dissociation of the platelet membrane glycoprotein(GP)IIb-IIIa, the alpha IIb beta 3 platelet-specific intergrin, a calcium-dependent heterodimer that serves as an inducible receptor for fibrinogen and is essential for platelet aggregation. Edetic Acid 0-4 fibrinogen beta chain Homo sapiens 227-237 1431204-4 1992 EDTA is known to induce an irreversible dissociation of the platelet membrane glycoprotein(GP)IIb-IIIa, the alpha IIb beta 3 platelet-specific intergrin, a calcium-dependent heterodimer that serves as an inducible receptor for fibrinogen and is essential for platelet aggregation. Calcium 156-163 fibrinogen beta chain Homo sapiens 227-237 1289495-0 1992 Disulfide bond cleavage of human fibrinogen by cis-diamminedichloroplatinum(II). Disulfides 0-9 fibrinogen beta chain Homo sapiens 33-43 1289495-0 1992 Disulfide bond cleavage of human fibrinogen by cis-diamminedichloroplatinum(II). Cisplatin 47-75 fibrinogen beta chain Homo sapiens 33-43 1289495-1 1992 Disulfide bridges in fibrinogen (Fbg) were cleaved by cis-diamminedichloroplatinum(II) (cis-DDP). Disulfides 0-9 fibrinogen beta chain Homo sapiens 21-31 1289495-1 1992 Disulfide bridges in fibrinogen (Fbg) were cleaved by cis-diamminedichloroplatinum(II) (cis-DDP). Disulfides 0-9 fibrinogen beta chain Homo sapiens 33-36 1289495-1 1992 Disulfide bridges in fibrinogen (Fbg) were cleaved by cis-diamminedichloroplatinum(II) (cis-DDP). Cisplatin 54-86 fibrinogen beta chain Homo sapiens 21-31 1289495-1 1992 Disulfide bridges in fibrinogen (Fbg) were cleaved by cis-diamminedichloroplatinum(II) (cis-DDP). Cisplatin 54-86 fibrinogen beta chain Homo sapiens 33-36 1289495-1 1992 Disulfide bridges in fibrinogen (Fbg) were cleaved by cis-diamminedichloroplatinum(II) (cis-DDP). Cisplatin 88-95 fibrinogen beta chain Homo sapiens 21-31 1289495-4 1992 The result indicates that calcium, which has three high affinity sites on Fbg, protects disulfide bridges from the rupture. Calcium 26-33 fibrinogen beta chain Homo sapiens 74-77 1289495-4 1992 The result indicates that calcium, which has three high affinity sites on Fbg, protects disulfide bridges from the rupture. Disulfides 88-97 fibrinogen beta chain Homo sapiens 74-77 1289495-6 1992 The cis-DDP treated Fbg was shown to give a decreased fiber thickness. Cisplatin 4-11 fibrinogen beta chain Homo sapiens 20-23 1391954-0 1992 Fibrinogen Marburg: a homozygous case of dysfibrinogenemia, lacking amino acids A alpha 461-610 (Lys 461 AAA-->stop TAA). Lysine 97-100 fibrinogen beta chain Homo sapiens 0-10 1391954-7 1992 Fibrinogen Marburg contained a substantial amount of albumin linked to the fibrinogen molecule by disulfide bonds, and these fibrinogen-albumin complexes were also present in plasma. Disulfides 98-107 fibrinogen beta chain Homo sapiens 0-10 1391954-7 1992 Fibrinogen Marburg contained a substantial amount of albumin linked to the fibrinogen molecule by disulfide bonds, and these fibrinogen-albumin complexes were also present in plasma. Disulfides 98-107 fibrinogen beta chain Homo sapiens 75-85 1425083-8 1992 Fibrinogen was correlated significantly with age (P less than 0.001), cholesterol (P = 0.002), CRP (P less than 0.001), and factor VII activity (P = 0.032), but not with plasma glucose, triglycerides, HDL cholesterol, or disease duration. Cholesterol 70-81 fibrinogen beta chain Homo sapiens 0-10 1425083-8 1992 Fibrinogen was correlated significantly with age (P less than 0.001), cholesterol (P = 0.002), CRP (P less than 0.001), and factor VII activity (P = 0.032), but not with plasma glucose, triglycerides, HDL cholesterol, or disease duration. Glucose 177-184 fibrinogen beta chain Homo sapiens 0-10 1425083-8 1992 Fibrinogen was correlated significantly with age (P less than 0.001), cholesterol (P = 0.002), CRP (P less than 0.001), and factor VII activity (P = 0.032), but not with plasma glucose, triglycerides, HDL cholesterol, or disease duration. Triglycerides 186-199 fibrinogen beta chain Homo sapiens 0-10 1425083-8 1992 Fibrinogen was correlated significantly with age (P less than 0.001), cholesterol (P = 0.002), CRP (P less than 0.001), and factor VII activity (P = 0.032), but not with plasma glucose, triglycerides, HDL cholesterol, or disease duration. Cholesterol 205-216 fibrinogen beta chain Homo sapiens 0-10 1328443-3 1992 Substitution of serine for cysteine was associated with a reduction in the effectiveness of interleukin-6 in both fibrinogen secretion assays. Serine 16-22 fibrinogen beta chain Homo sapiens 114-124 1328443-3 1992 Substitution of serine for cysteine was associated with a reduction in the effectiveness of interleukin-6 in both fibrinogen secretion assays. Cysteine 27-35 fibrinogen beta chain Homo sapiens 114-124 1440530-8 1992 Fibrinogen correlated positively with fasting blood glucose (p < 0.05) and Thrombin-Antithrombin complexes with glycosylated haemoglobin (p < 0.05), whereas Factor VII was positively correlated with glycemia (p < 0.01) and glycosylated haemoglobin (p < 0.05). Glucose 52-59 fibrinogen beta chain Homo sapiens 0-10 1519672-3 1992 The current study used standardized stereology in conjunction with immunogold electron microscopy to correlate the initial morphologic changes with fibrinogen receptor localization on the surfaces of ADP-activated human platelets. Adenosine Diphosphate 200-203 fibrinogen beta chain Homo sapiens 148-158 1503326-8 1992 MEASUREMENTS: Deep vein thrombosis was diagnosed using 125I-labeled fibrinogen leg scanning and impedance plethysmography. Iodine-125 55-59 fibrinogen beta chain Homo sapiens 68-78 1355374-8 1992 Exogenous fibrinogen strongly enhanced the effects of ADP and U 46619. Adenosine Diphosphate 54-57 fibrinogen beta chain Homo sapiens 10-20 1332992-0 1992 [Low-molecular heparin complex formation with the blood coagulation proteins--thrombin and fibrinogen]. Heparin 15-22 fibrinogen beta chain Homo sapiens 91-101 1332992-1 1992 It has been found that low molecular heparin (LMH) forms complexes with fibrinogen and thrombin. Heparin 37-44 fibrinogen beta chain Homo sapiens 72-82 1332992-1 1992 It has been found that low molecular heparin (LMH) forms complexes with fibrinogen and thrombin. LMH 46-49 fibrinogen beta chain Homo sapiens 72-82 1512327-9 1992 Heparin administration was associated with a smaller reduction in fibrinogen and a smaller increase in D-dimer level during and after alteplase administration. Heparin 0-7 fibrinogen beta chain Homo sapiens 66-76 1331117-6 1992 Fibrinogen adsorption increased on oxide layer coated and hydroxyapatite coated surfaces, compared to bare tantalum. Oxides 35-40 fibrinogen beta chain Homo sapiens 0-10 1331117-6 1992 Fibrinogen adsorption increased on oxide layer coated and hydroxyapatite coated surfaces, compared to bare tantalum. Durapatite 58-72 fibrinogen beta chain Homo sapiens 0-10 1429764-1 1992 Whereas it has been commonly thought that adding polyethylene oxide PEO to a surface would diminish the capacity of the surface to cause deposition of platelets and of fibrinogen, and to activate complement C3, we present data showing exactly the opposite. Polyethylene Glycols 49-67 fibrinogen beta chain Homo sapiens 168-178 1421580-4 1992 Stimulation of these cells either by adhesion to fibrinogen or with antiserum directed against alpha IIb beta 3 results in induction of calcium oscillations, followed by tyrosine phosphorylation of at least one protein of molecular weight approximately 125 kDa. Calcium 136-143 fibrinogen beta chain Homo sapiens 49-59 1421580-4 1992 Stimulation of these cells either by adhesion to fibrinogen or with antiserum directed against alpha IIb beta 3 results in induction of calcium oscillations, followed by tyrosine phosphorylation of at least one protein of molecular weight approximately 125 kDa. Tyrosine 170-178 fibrinogen beta chain Homo sapiens 49-59 1355621-3 1992 When the cryoprecipitated pellet was resuspended in 0.5 to 2 mL of saline (total volume of saline-resuspended fibrinogen: 5 mL), the average yield of fibrinogen was 78.4 +/- 18.3 mg per mL. Sodium Chloride 91-97 fibrinogen beta chain Homo sapiens 110-120 1448785-6 1992 MT-induced responses are blocked by PGE1 or ajoene (which inhibits binding of fibrinogen to its cell surface receptor, GPIIb/IIIa). Alprostadil 36-40 fibrinogen beta chain Homo sapiens 78-88 1448785-6 1992 MT-induced responses are blocked by PGE1 or ajoene (which inhibits binding of fibrinogen to its cell surface receptor, GPIIb/IIIa). ajoene 44-50 fibrinogen beta chain Homo sapiens 78-88 1324718-1 1992 The rotational motions of human fibrinogen in solution at 20 degrees C have been examined, in the 0.2-12-microseconds time range, by measuring the laser-induced dichroism of the triplet state of an erythrosin probe covalently bonded to the protein. Erythrosine 198-208 fibrinogen beta chain Homo sapiens 32-42 1324718-5 1992 The possibility of Ca(2+)-dependent changes in the rigidity or conformation of fibrinogen was excluded by examining the submicrosecond time-resolved fluorescence depolarization of 1-methylpyrene conjugates of the protein in the presence of different calcium concentrations. 1-methylpyrene 180-194 fibrinogen beta chain Homo sapiens 79-89 1440503-3 1992 Two agents were identified, Zn2+ and phorbol myristate acetate (PMA), which support progressive decreases in bound fibrinogen expression on platelets, but fail to support the stabilization of fibrinogen binding. Zinc 28-32 fibrinogen beta chain Homo sapiens 115-125 1440503-3 1992 Two agents were identified, Zn2+ and phorbol myristate acetate (PMA), which support progressive decreases in bound fibrinogen expression on platelets, but fail to support the stabilization of fibrinogen binding. Tetradecanoylphorbol Acetate 37-62 fibrinogen beta chain Homo sapiens 115-125 1440503-3 1992 Two agents were identified, Zn2+ and phorbol myristate acetate (PMA), which support progressive decreases in bound fibrinogen expression on platelets, but fail to support the stabilization of fibrinogen binding. Tetradecanoylphorbol Acetate 64-67 fibrinogen beta chain Homo sapiens 115-125 1440503-4 1992 Sixty min after binding to platelets, approximately 80% of bound fibrinogen remained reversibly associated with Zn(2+)- or PMA-treated platelets and failed to associate with the Triton X-100 insoluble cytoskeleton. Zinc 112-114 fibrinogen beta chain Homo sapiens 65-75 1440503-4 1992 Sixty min after binding to platelets, approximately 80% of bound fibrinogen remained reversibly associated with Zn(2+)- or PMA-treated platelets and failed to associate with the Triton X-100 insoluble cytoskeleton. Tetradecanoylphorbol Acetate 123-126 fibrinogen beta chain Homo sapiens 65-75 1440503-6 1992 Over the same time course, fibrinogen binding to control platelets, stimulated with thrombin or ADP, was not only accompanied by a 70% decrease in antifibrinogen antibody binding, but also an inability of EDTA or excess exogenous fibrinogen to dissociate more than half of platelet-associated fibrinogen, as well as the progressive association of bound fibrinogen with the platelet cytoskeleton. Edetic Acid 205-209 fibrinogen beta chain Homo sapiens 27-37 1354234-2 1992 Substitution of Mn2+ for Ca2+ and Mg2+ significantly increased adhesion of human PMN to plastic well coated with fibronectin, fibrinogen, and laminin but not gelatin. Manganese(2+) 16-20 fibrinogen beta chain Homo sapiens 126-136 1354234-2 1992 Substitution of Mn2+ for Ca2+ and Mg2+ significantly increased adhesion of human PMN to plastic well coated with fibronectin, fibrinogen, and laminin but not gelatin. magnesium ion 34-38 fibrinogen beta chain Homo sapiens 126-136 1354234-4 1992 In contrast, anti-very late antigen (VLA)-5 mAb antibodies significantly reduced Mn(2+)-mediated PMN adherence to fibronectin, but not to laminin or fibrinogen, demonstrating that VLA-5-mediated PMN adherence to fibronectin, but not to fibrinogen or laminin. Manganese(2+) 81-87 fibrinogen beta chain Homo sapiens 236-246 1644841-1 1992 The platelet integrin, glycoprotein IIb-IIIa (GPIIb-IIIa), is a calcium-dependent heterodimer that binds fibrinogen, von Willebrand factor, and fibronectin after platelet activation. Calcium 64-71 fibrinogen beta chain Homo sapiens 105-115 1412224-7 1992 Thrombin, and to a less extent ADP, increased the binding of FITC-conjugated fibrinogen to normal platelets but had no significant effect on the expression of GPIIIa. Adenosine Diphosphate 31-34 fibrinogen beta chain Homo sapiens 77-87 1412224-7 1992 Thrombin, and to a less extent ADP, increased the binding of FITC-conjugated fibrinogen to normal platelets but had no significant effect on the expression of GPIIIa. Fluorescein-5-isothiocyanate 61-65 fibrinogen beta chain Homo sapiens 77-87 1412170-7 1992 We have developed a method for measuring platelet-bound fibrinogen in whole blood and platelet-rich plasma utilising fluorescein isothiocyanate (FITC)-conjugated chicken antibodies directed towards human fibrinogen. Fluorescein-5-isothiocyanate 117-143 fibrinogen beta chain Homo sapiens 56-66 1412170-7 1992 We have developed a method for measuring platelet-bound fibrinogen in whole blood and platelet-rich plasma utilising fluorescein isothiocyanate (FITC)-conjugated chicken antibodies directed towards human fibrinogen. Fluorescein-5-isothiocyanate 117-143 fibrinogen beta chain Homo sapiens 204-214 1412170-7 1992 We have developed a method for measuring platelet-bound fibrinogen in whole blood and platelet-rich plasma utilising fluorescein isothiocyanate (FITC)-conjugated chicken antibodies directed towards human fibrinogen. Fluorescein-5-isothiocyanate 145-149 fibrinogen beta chain Homo sapiens 56-66 1412170-7 1992 We have developed a method for measuring platelet-bound fibrinogen in whole blood and platelet-rich plasma utilising fluorescein isothiocyanate (FITC)-conjugated chicken antibodies directed towards human fibrinogen. Fluorescein-5-isothiocyanate 145-149 fibrinogen beta chain Homo sapiens 204-214 1639797-6 1992 Purified phosphatidic acid dose-dependently promoted a specific interaction between glycoprotein IIb-IIIa and fibrinogen which possessed many but not all of the properties of fibrinogen binding to activated platelets. Phosphatidic Acids 9-26 fibrinogen beta chain Homo sapiens 110-120 1639797-7 1992 Phosphatidic acid appeared to increase the proportion of fibrinogen binding-competent glycoprotein IIb-IIIa complexes without altering their affinity for fibrinogen. Phosphatidic Acids 0-17 fibrinogen beta chain Homo sapiens 57-67 1639797-9 1992 Lysophosphatidic acid, however, was a potent inducer of fibrinogen binding to glycoprotein IIb-IIIa. lysophosphatidic acid 0-21 fibrinogen beta chain Homo sapiens 56-66 1418078-0 1992 Fibrinogen and antithrombin III blood levels fluctuations during isoniazid or isoniazid plus rifampicin administration. Isoniazid 65-74 fibrinogen beta chain Homo sapiens 0-10 1418078-0 1992 Fibrinogen and antithrombin III blood levels fluctuations during isoniazid or isoniazid plus rifampicin administration. Isoniazid 78-87 fibrinogen beta chain Homo sapiens 0-10 1418078-0 1992 Fibrinogen and antithrombin III blood levels fluctuations during isoniazid or isoniazid plus rifampicin administration. Rifampin 93-103 fibrinogen beta chain Homo sapiens 0-10 1429753-0 1992 Polyurethanes bearing pendant amino acids: fibrinogen adsorption and coagulant properties. Polyurethanes 0-13 fibrinogen beta chain Homo sapiens 43-53 1429753-0 1992 Polyurethanes bearing pendant amino acids: fibrinogen adsorption and coagulant properties. pendant amino acids 22-41 fibrinogen beta chain Homo sapiens 43-53 1429753-6 1992 Fibrinogen adsorption from plasma, shown previously to be high on the sulfonated polyurethanes, was reduced by derivatization, due probably to the decrease in free sulfonate content. Polyurethanes 81-94 fibrinogen beta chain Homo sapiens 0-10 1429753-6 1992 Fibrinogen adsorption from plasma, shown previously to be high on the sulfonated polyurethanes, was reduced by derivatization, due probably to the decrease in free sulfonate content. sulfonate 70-79 fibrinogen beta chain Homo sapiens 0-10 1399825-1 1992 Triflavin, an Arg-Gly-Asp (RGD) containing peptide purified from Trimeresurus flavoviridis snake venom, inhibits human platelet aggregation by blocking fibrinogen binding to fibrinogen receptors associated with glycoprotein IIb/IIIa complex. triflavin 0-9 fibrinogen beta chain Homo sapiens 152-162 1399825-1 1992 Triflavin, an Arg-Gly-Asp (RGD) containing peptide purified from Trimeresurus flavoviridis snake venom, inhibits human platelet aggregation by blocking fibrinogen binding to fibrinogen receptors associated with glycoprotein IIb/IIIa complex. triflavin 0-9 fibrinogen beta chain Homo sapiens 174-184 1399825-3 1992 In vitro, triflavin dose-dependently inhibits adhesion of B16-F10 melanoma cells to extracellular matrices (ECMs; i.e., fibronectin, fibrinogen, vitronectin, and collagen type I). triflavin 10-19 fibrinogen beta chain Homo sapiens 133-143 1324718-5 1992 The possibility of Ca(2+)-dependent changes in the rigidity or conformation of fibrinogen was excluded by examining the submicrosecond time-resolved fluorescence depolarization of 1-methylpyrene conjugates of the protein in the presence of different calcium concentrations. Calcium 250-257 fibrinogen beta chain Homo sapiens 79-89 1616903-0 1992 Determinants of plasma fibrinogen: relation to body weight, waist-to-hip ratio, smoking, alcohol, age, and sex. Alcohols 89-96 fibrinogen beta chain Homo sapiens 23-33 1616903-4 1992 Fibrinogen concentrations were positively correlated (p less than or equal to 0.0001) with age, body mass index, and waist-to-hip ratio in both sexes and with cigarette smoking in men and were negatively correlated with alcohol consumption in both sexes. Alcohols 220-227 fibrinogen beta chain Homo sapiens 0-10 1616903-10 1992 This impact on the population fibrinogen level was most pronounced for age in both sexes, followed by body mass index, cigarette smoking, and alcohol consumption in women and by smoking, waist-to-hip ratio, and alcohol consumption in men. Alcohols 142-149 fibrinogen beta chain Homo sapiens 30-40 1616903-10 1992 This impact on the population fibrinogen level was most pronounced for age in both sexes, followed by body mass index, cigarette smoking, and alcohol consumption in women and by smoking, waist-to-hip ratio, and alcohol consumption in men. Alcohols 211-218 fibrinogen beta chain Homo sapiens 30-40 1634621-0 1992 Fibrinogen Lima: a homozygous dysfibrinogen with an A alpha-arginine-141 to serine substitution associated with extra N-glycosylation at A alpha-asparagine-139. Isoasparagine 139-155 fibrinogen beta chain Homo sapiens 0-10 1634621-3 1992 The point mutation created an asparagine-X-serine-type glycosylation sequence, and indeed, extra, mainly disialylated biantennary oligosaccharides have been isolated from A alpha asparagine-139 of the patient"s fibrinogen. Asparagine 30-40 fibrinogen beta chain Homo sapiens 211-221 1634621-3 1992 The point mutation created an asparagine-X-serine-type glycosylation sequence, and indeed, extra, mainly disialylated biantennary oligosaccharides have been isolated from A alpha asparagine-139 of the patient"s fibrinogen. x-serine 41-49 fibrinogen beta chain Homo sapiens 211-221 1634621-3 1992 The point mutation created an asparagine-X-serine-type glycosylation sequence, and indeed, extra, mainly disialylated biantennary oligosaccharides have been isolated from A alpha asparagine-139 of the patient"s fibrinogen. Oligosaccharides 130-146 fibrinogen beta chain Homo sapiens 211-221 1634621-3 1992 The point mutation created an asparagine-X-serine-type glycosylation sequence, and indeed, extra, mainly disialylated biantennary oligosaccharides have been isolated from A alpha asparagine-139 of the patient"s fibrinogen. Asparagine 179-189 fibrinogen beta chain Homo sapiens 211-221 1634621-4 1992 This type of glycosylation sequence is unique for human fibrinogen, because the sequences shown for normal and abnormal fibrinogens are all asparagine-X-threonine types. asparagine-x-threonine 140-162 fibrinogen beta chain Homo sapiens 56-66 1507499-1 1992 We previously analysed the fragments of fibrin/fibrinogen degradation products (FDP) by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) combined with immunoblotting. Sodium Dodecyl Sulfate 88-110 fibrinogen beta chain Homo sapiens 47-57 1507499-1 1992 We previously analysed the fragments of fibrin/fibrinogen degradation products (FDP) by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) combined with immunoblotting. polyacrylamide 111-125 fibrinogen beta chain Homo sapiens 47-57 1507499-1 1992 We previously analysed the fragments of fibrin/fibrinogen degradation products (FDP) by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) combined with immunoblotting. Sodium Dodecyl Sulfate 147-150 fibrinogen beta chain Homo sapiens 47-57 1377908-1 1992 Okadaic acid (OA), a specific inhibitor of protein phosphatases 1 and 2A, inhibited in a dose-dependent manner (5-20 nM) the induction of C-reactive protein (CRP), serum amyloid A (SAA) and fibrinogen by interleukin-6 (IL-6) plus interleukin-1 (IL-1), and of fibrinogen by IL-6 alone, in Hep 3B cells. Okadaic Acid 0-12 fibrinogen beta chain Homo sapiens 190-200 1377908-1 1992 Okadaic acid (OA), a specific inhibitor of protein phosphatases 1 and 2A, inhibited in a dose-dependent manner (5-20 nM) the induction of C-reactive protein (CRP), serum amyloid A (SAA) and fibrinogen by interleukin-6 (IL-6) plus interleukin-1 (IL-1), and of fibrinogen by IL-6 alone, in Hep 3B cells. Okadaic Acid 0-12 fibrinogen beta chain Homo sapiens 259-269 1377908-1 1992 Okadaic acid (OA), a specific inhibitor of protein phosphatases 1 and 2A, inhibited in a dose-dependent manner (5-20 nM) the induction of C-reactive protein (CRP), serum amyloid A (SAA) and fibrinogen by interleukin-6 (IL-6) plus interleukin-1 (IL-1), and of fibrinogen by IL-6 alone, in Hep 3B cells. Okadaic Acid 14-16 fibrinogen beta chain Homo sapiens 190-200 1377908-1 1992 Okadaic acid (OA), a specific inhibitor of protein phosphatases 1 and 2A, inhibited in a dose-dependent manner (5-20 nM) the induction of C-reactive protein (CRP), serum amyloid A (SAA) and fibrinogen by interleukin-6 (IL-6) plus interleukin-1 (IL-1), and of fibrinogen by IL-6 alone, in Hep 3B cells. Okadaic Acid 14-16 fibrinogen beta chain Homo sapiens 259-269 1519227-1 1992 Triflavin, an Arg-Gly-Asp (RGD)-containing peptide, purified from snake venom of Trimeresurus flavoviridis, inhibits human platelet aggregation through the blockade of fibrinogen binding to fibrinogen receptors associated with glycoprotein IIb/IIIa complex. triflavin 0-9 fibrinogen beta chain Homo sapiens 168-178 1519227-1 1992 Triflavin, an Arg-Gly-Asp (RGD)-containing peptide, purified from snake venom of Trimeresurus flavoviridis, inhibits human platelet aggregation through the blockade of fibrinogen binding to fibrinogen receptors associated with glycoprotein IIb/IIIa complex. triflavin 0-9 fibrinogen beta chain Homo sapiens 190-200 1519227-10 1992 In conclusion, we suggest the inhibitory effect of triflavin on J-5 TCIPA may be chiefly mediated by the binding of triflavin to the fibrinogen receptor associated with glycoprotein IIb/IIIa complex on platelet surface membrane. triflavin 51-60 fibrinogen beta chain Homo sapiens 133-143 1519227-10 1992 In conclusion, we suggest the inhibitory effect of triflavin on J-5 TCIPA may be chiefly mediated by the binding of triflavin to the fibrinogen receptor associated with glycoprotein IIb/IIIa complex on platelet surface membrane. triflavin 116-125 fibrinogen beta chain Homo sapiens 133-143 1519230-5 1992 Following reduction of this protein by 2-mercaptoethanol after extraction from SDS-PAGE gel, gamma-chain of fibrinogen (47 kDa) was found by immunoblotting using a monoclonal antibody recognising a 86-302 residue of the gamma-remnant of fibrinogen. Mercaptoethanol 39-56 fibrinogen beta chain Homo sapiens 108-118 1519230-5 1992 Following reduction of this protein by 2-mercaptoethanol after extraction from SDS-PAGE gel, gamma-chain of fibrinogen (47 kDa) was found by immunoblotting using a monoclonal antibody recognising a 86-302 residue of the gamma-remnant of fibrinogen. Sodium Dodecyl Sulfate 79-82 fibrinogen beta chain Homo sapiens 108-118 1385959-0 1992 Effects of niceritrol on levels of serum lipids, lipoprotein(a), and fibrinogen in patients with primary hypercholesterolemia. Niceritrol 11-21 fibrinogen beta chain Homo sapiens 69-79 1417409-2 1992 It has since been shown that Omega-3 fatty acids have a number of beneficial effects in the prevention of atherosclerosis in man: reduction of blood pressure, modifications of lipoprotein metabolism, modifications of haemostasis (increased bleeding time and reduced platelet aggregation), decreased plasma fibrinogen, modifications of the metabolism of arachidonic acid and its derivatives (decreased thromboxane and leukotriene synthesis, increased prostacyclin synthesis). Fatty Acids, Omega-3 29-48 fibrinogen beta chain Homo sapiens 306-316 1597001-0 1992 Effect of processing time and storage on fibrinogen content of EDTA plasma assayed by radial immunodiffusion. Edetic Acid 63-67 fibrinogen beta chain Homo sapiens 41-51 1440503-7 1992 Costimulation of platelets with ZnCl2 and thrombin or ZnCl2 and ADP enhanced overall fibrinogen binding but not the EDTA-resistant component, and prevented the recovery of irreversibly bound fibrinogen with the Triton X-100 insoluble cytoskeleton. zinc chloride 32-37 fibrinogen beta chain Homo sapiens 85-95 1602006-6 1992 ADP-stimulated platelets bound markedly reduced amounts of soluble fibrinogen and platelet adhesion to surface-bound fibrinogen was defective. Adenosine Diphosphate 0-3 fibrinogen beta chain Homo sapiens 67-77 1440503-7 1992 Costimulation of platelets with ZnCl2 and thrombin or ZnCl2 and ADP enhanced overall fibrinogen binding but not the EDTA-resistant component, and prevented the recovery of irreversibly bound fibrinogen with the Triton X-100 insoluble cytoskeleton. zinc chloride 32-37 fibrinogen beta chain Homo sapiens 191-201 1440503-7 1992 Costimulation of platelets with ZnCl2 and thrombin or ZnCl2 and ADP enhanced overall fibrinogen binding but not the EDTA-resistant component, and prevented the recovery of irreversibly bound fibrinogen with the Triton X-100 insoluble cytoskeleton. zinc chloride 54-59 fibrinogen beta chain Homo sapiens 85-95 1440503-7 1992 Costimulation of platelets with ZnCl2 and thrombin or ZnCl2 and ADP enhanced overall fibrinogen binding but not the EDTA-resistant component, and prevented the recovery of irreversibly bound fibrinogen with the Triton X-100 insoluble cytoskeleton. zinc chloride 54-59 fibrinogen beta chain Homo sapiens 191-201 1440503-7 1992 Costimulation of platelets with ZnCl2 and thrombin or ZnCl2 and ADP enhanced overall fibrinogen binding but not the EDTA-resistant component, and prevented the recovery of irreversibly bound fibrinogen with the Triton X-100 insoluble cytoskeleton. Adenosine Diphosphate 64-67 fibrinogen beta chain Homo sapiens 85-95 1440503-7 1992 Costimulation of platelets with ZnCl2 and thrombin or ZnCl2 and ADP enhanced overall fibrinogen binding but not the EDTA-resistant component, and prevented the recovery of irreversibly bound fibrinogen with the Triton X-100 insoluble cytoskeleton. Adenosine Diphosphate 64-67 fibrinogen beta chain Homo sapiens 191-201 1440503-7 1992 Costimulation of platelets with ZnCl2 and thrombin or ZnCl2 and ADP enhanced overall fibrinogen binding but not the EDTA-resistant component, and prevented the recovery of irreversibly bound fibrinogen with the Triton X-100 insoluble cytoskeleton. Octoxynol 211-223 fibrinogen beta chain Homo sapiens 191-201 1440503-8 1992 Costimulation of PMA- or Zn(2+)-treated platelets with low doses of A23187, however, restored the stabilization of platelet-fibrinogen interactions. Tetradecanoylphorbol Acetate 17-20 fibrinogen beta chain Homo sapiens 124-134 1440503-8 1992 Costimulation of PMA- or Zn(2+)-treated platelets with low doses of A23187, however, restored the stabilization of platelet-fibrinogen interactions. Zinc 25-31 fibrinogen beta chain Homo sapiens 124-134 1440503-8 1992 Costimulation of PMA- or Zn(2+)-treated platelets with low doses of A23187, however, restored the stabilization of platelet-fibrinogen interactions. Calcimycin 68-74 fibrinogen beta chain Homo sapiens 124-134 1527100-0 1992 Reduction of fibrinogen adsorption on PEG-coated polystyrene surfaces. Polyethylene Glycols 38-41 fibrinogen beta chain Homo sapiens 13-23 1527100-0 1992 Reduction of fibrinogen adsorption on PEG-coated polystyrene surfaces. Polystyrenes 49-60 fibrinogen beta chain Homo sapiens 13-23 1527100-5 1992 The results of protein adsorption studies showed that fibrinogen adsorption is significantly reduced by coating polystyrene with either linear or branched PEGs of 1500 to 20,000 in molecular weight. Polystyrenes 112-123 fibrinogen beta chain Homo sapiens 54-64 1527100-5 1992 The results of protein adsorption studies showed that fibrinogen adsorption is significantly reduced by coating polystyrene with either linear or branched PEGs of 1500 to 20,000 in molecular weight. Polyethylene Glycols 155-159 fibrinogen beta chain Homo sapiens 54-64 1382726-1 1992 The ability of various peptides cleaved by plasmin from human fibrinogen and fibronectin or fibrinogen- and fibronectin- related synthetic peptides to induce histamine release from mast cells and collagenase and elastase from PMN-leukocytes was examined. Peptides 23-31 fibrinogen beta chain Homo sapiens 62-72 1382726-1 1992 The ability of various peptides cleaved by plasmin from human fibrinogen and fibronectin or fibrinogen- and fibronectin- related synthetic peptides to induce histamine release from mast cells and collagenase and elastase from PMN-leukocytes was examined. Histamine 158-167 fibrinogen beta chain Homo sapiens 92-103 1597855-8 1992 G-4120 was equipotent in the platelet aggregation assay to kistrin, a highly potent inhibitor of fibrinogen-mediated platelet aggregation isolated from snake venom (IC50 = 0.15 microM). G 4120 0-6 fibrinogen beta chain Homo sapiens 97-107 1597855-8 1992 G-4120 was equipotent in the platelet aggregation assay to kistrin, a highly potent inhibitor of fibrinogen-mediated platelet aggregation isolated from snake venom (IC50 = 0.15 microM). kistrin 59-66 fibrinogen beta chain Homo sapiens 97-107 1586714-0 1992 Characterization of the gamma chain platelet binding site on fibrinogen fragment D. Glycoprotein (GP) IIb/IIIa on adenosine diphosphate (ADP)-activated human platelets interacts with specific sites on the fibrinogen molecule leading to aggregation. Adenosine Diphosphate 114-135 fibrinogen beta chain Homo sapiens 61-71 1586714-0 1992 Characterization of the gamma chain platelet binding site on fibrinogen fragment D. Glycoprotein (GP) IIb/IIIa on adenosine diphosphate (ADP)-activated human platelets interacts with specific sites on the fibrinogen molecule leading to aggregation. Adenosine Diphosphate 114-135 fibrinogen beta chain Homo sapiens 205-215 1586714-0 1992 Characterization of the gamma chain platelet binding site on fibrinogen fragment D. Glycoprotein (GP) IIb/IIIa on adenosine diphosphate (ADP)-activated human platelets interacts with specific sites on the fibrinogen molecule leading to aggregation. Adenosine Diphosphate 137-140 fibrinogen beta chain Homo sapiens 61-71 1586714-0 1992 Characterization of the gamma chain platelet binding site on fibrinogen fragment D. Glycoprotein (GP) IIb/IIIa on adenosine diphosphate (ADP)-activated human platelets interacts with specific sites on the fibrinogen molecule leading to aggregation. Adenosine Diphosphate 137-140 fibrinogen beta chain Homo sapiens 205-215 1517349-1 1992 The three proteins phosphorylase b, calmodulin and fibrinogen are adsorbed onto thioalkyl derivatives of Sepharose much more strongly than onto gels carrying the same alkyl residue coupled via a carbamate linkage. Sepharose 105-114 fibrinogen beta chain Homo sapiens 51-61 1517349-1 1992 The three proteins phosphorylase b, calmodulin and fibrinogen are adsorbed onto thioalkyl derivatives of Sepharose much more strongly than onto gels carrying the same alkyl residue coupled via a carbamate linkage. Carbamates 195-204 fibrinogen beta chain Homo sapiens 51-61 1562729-1 1992 Progressive decreases in platelet-bound fibrinogen accessibility to antibody and enzymes were recently reported to occur after adenosine diphosphate (ADP)-induced fibrinogen binding. Adenosine Diphosphate 127-148 fibrinogen beta chain Homo sapiens 40-50 1562729-1 1992 Progressive decreases in platelet-bound fibrinogen accessibility to antibody and enzymes were recently reported to occur after adenosine diphosphate (ADP)-induced fibrinogen binding. Adenosine Diphosphate 127-148 fibrinogen beta chain Homo sapiens 163-173 1562729-1 1992 Progressive decreases in platelet-bound fibrinogen accessibility to antibody and enzymes were recently reported to occur after adenosine diphosphate (ADP)-induced fibrinogen binding. Adenosine Diphosphate 150-153 fibrinogen beta chain Homo sapiens 40-50 1562729-1 1992 Progressive decreases in platelet-bound fibrinogen accessibility to antibody and enzymes were recently reported to occur after adenosine diphosphate (ADP)-induced fibrinogen binding. Adenosine Diphosphate 150-153 fibrinogen beta chain Homo sapiens 163-173 1562729-5 1992 Pretreatment of ADP-stimulated platelets with chymotrypsin largely prevented the progressive loss of platelet aggregability and the accompanying decreased recognition of bound fibrinogen by antifibrinogen F(ab")2 fragments. Adenosine Diphosphate 16-19 fibrinogen beta chain Homo sapiens 176-186 1562729-6 1992 Preincubation of platelets with cytochalasin D (30 micrograms/mL) also inhibited the decrease in platelet aggregation after exposure of ADP-treated platelets to fibrinogen over a 60-minute time course. Cytochalasin D 32-46 fibrinogen beta chain Homo sapiens 161-171 1562729-6 1992 Preincubation of platelets with cytochalasin D (30 micrograms/mL) also inhibited the decrease in platelet aggregation after exposure of ADP-treated platelets to fibrinogen over a 60-minute time course. Adenosine Diphosphate 136-139 fibrinogen beta chain Homo sapiens 161-171 1565641-0 1992 Abnormal fibrinogens IJmuiden (B beta Arg14----Cys) and Nijmegen (B beta Arg44----Cys) form disulfide-linked fibrinogen-albumin complexes. Disulfides 92-101 fibrinogen beta chain Homo sapiens 9-19 1581407-11 1992 Long-term treatment with lovastatin was associated with a significant reduction of fibrinogen levels and platelet aggregation induced by ADP in type-IIa hypercholesterolemic patients. Lovastatin 25-35 fibrinogen beta chain Homo sapiens 83-93 1604240-1 1992 Murine hepatocytes cultured in the presence of human recombinant interleukin-6 (IL-6) show increased synthesis of fibrinogen and complement component C3 by the addition of histamine. Histamine 172-181 fibrinogen beta chain Homo sapiens 114-124 1631981-3 1992 In 42 heart and lung operations, autologous fibrin tissue adhesive prepared by a new method was employed in which the fibrinogen is separated from the patient"s own plasma by precipitation with ethanol. Ethanol 194-201 fibrinogen beta chain Homo sapiens 118-128 1581297-1 1992 Fibrinogen Lille, a congenital dysfibrinogenemia, has been reported to arise from a mutation from Asp to Asn at position 7 of the A alpha chain of human fibrinogen, thereby reducing the thrombin-catalyzed rate of hydrolysis of the Arg(16)-Gly(17) peptide bond of this chain. Arginine 231-234 fibrinogen beta chain Homo sapiens 0-10 1581297-1 1992 Fibrinogen Lille, a congenital dysfibrinogenemia, has been reported to arise from a mutation from Asp to Asn at position 7 of the A alpha chain of human fibrinogen, thereby reducing the thrombin-catalyzed rate of hydrolysis of the Arg(16)-Gly(17) peptide bond of this chain. Arginine 231-234 fibrinogen beta chain Homo sapiens 34-44 1581297-1 1992 Fibrinogen Lille, a congenital dysfibrinogenemia, has been reported to arise from a mutation from Asp to Asn at position 7 of the A alpha chain of human fibrinogen, thereby reducing the thrombin-catalyzed rate of hydrolysis of the Arg(16)-Gly(17) peptide bond of this chain. Glycine 239-242 fibrinogen beta chain Homo sapiens 0-10 1581297-1 1992 Fibrinogen Lille, a congenital dysfibrinogenemia, has been reported to arise from a mutation from Asp to Asn at position 7 of the A alpha chain of human fibrinogen, thereby reducing the thrombin-catalyzed rate of hydrolysis of the Arg(16)-Gly(17) peptide bond of this chain. Glycine 239-242 fibrinogen beta chain Homo sapiens 34-44 1397477-9 1992 BZF alone led to a significant 25% decrease in plasma fibrinogen (from 415 +/- 14.3 to 312.1 +/- 18.1 SEM mg/dl, p less than 0.001). Bezafibrate 0-3 fibrinogen beta chain Homo sapiens 54-64 1560020-1 1992 The tetradecapeptide Ac-D-F-L-A-E-G-G-G-V-R-G-P-R-V-OMe, which mimics residues 7f-20f of the A alpha-chain of human fibrinogen, has been co-crystallized with bovine thrombin from ammonium sulfate solutions in space group P2(1) with unit cell dimensions of a = 83.0 A, b = 89.4 A, c = 99.3 A, and beta = 106.6 degrees. ac-d-f-l-a 21-31 fibrinogen beta chain Homo sapiens 116-126 1560020-1 1992 The tetradecapeptide Ac-D-F-L-A-E-G-G-G-V-R-G-P-R-V-OMe, which mimics residues 7f-20f of the A alpha-chain of human fibrinogen, has been co-crystallized with bovine thrombin from ammonium sulfate solutions in space group P2(1) with unit cell dimensions of a = 83.0 A, b = 89.4 A, c = 99.3 A, and beta = 106.6 degrees. g-g-v-r-g-p-r-v-ome 36-55 fibrinogen beta chain Homo sapiens 116-126 1575681-0 1992 Spiking in cytosolic calcium concentration in single fibrinogen-bound fura-2-loaded human platelets. Calcium 21-28 fibrinogen beta chain Homo sapiens 53-63 1575681-0 1992 Spiking in cytosolic calcium concentration in single fibrinogen-bound fura-2-loaded human platelets. Fura-2 70-76 fibrinogen beta chain Homo sapiens 53-63 1575681-1 1992 Fura-2-loaded human platelets were immobilized on a fibrinogen-coated surface and the cytosolic free calcium concentration ([Ca2+]i) was measured in single platelets by low-light-level video-ratio image-processing of the optical probe signal. Fura-2 0-6 fibrinogen beta chain Homo sapiens 52-62 1575681-2 1992 Some fibrinogen-bound platelets showed repetitive spiking in [Ca2+]i with a mean frequency of about 2/min, which increased to 5/min in the presence of ADP. Adenosine Diphosphate 151-154 fibrinogen beta chain Homo sapiens 5-15 1575681-4 1992 When immobilized in the presence of prostaglandin I2 and the fibrinogen antagonist Arg-Gly-Asp-Ser, the platelets adhered less firmly to fibrinogen, and in many [Ca2+]i remained low and constant. Epoprostenol 36-52 fibrinogen beta chain Homo sapiens 137-147 1575681-4 1992 When immobilized in the presence of prostaglandin I2 and the fibrinogen antagonist Arg-Gly-Asp-Ser, the platelets adhered less firmly to fibrinogen, and in many [Ca2+]i remained low and constant. arginyl-glycyl-aspartyl-serine 83-98 fibrinogen beta chain Homo sapiens 61-71 1575681-4 1992 When immobilized in the presence of prostaglandin I2 and the fibrinogen antagonist Arg-Gly-Asp-Ser, the platelets adhered less firmly to fibrinogen, and in many [Ca2+]i remained low and constant. arginyl-glycyl-aspartyl-serine 83-98 fibrinogen beta chain Homo sapiens 137-147 1602006-6 1992 ADP-stimulated platelets bound markedly reduced amounts of soluble fibrinogen and platelet adhesion to surface-bound fibrinogen was defective. Adenosine Diphosphate 0-3 fibrinogen beta chain Homo sapiens 117-127 1602006-7 1992 Normal to subnormal amounts of glycoprotein (GP) IIb-IIIa (alpha IIb beta 3) complexes, the platelet fibrinogen receptor, were revealed by SDS-PAGE, crossed immunoelectrophoresis, and antibody binding. Sodium Dodecyl Sulfate 139-142 fibrinogen beta chain Homo sapiens 101-111 1602006-14 1992 This substitution points to an essential amino acid in a region of GPIIIa involved in the binding of fibrinogen and influencing the Ca(2+)-dependent stability of the GPIIb-IIIa complex. Amino Acids, Essential 31-51 fibrinogen beta chain Homo sapiens 101-111 1568318-5 1992 We conclude that the persistence of fibrinogen in serum samples from patients treated with anticoagulants is a potential interference in Ferrozine dye-binding methods performed without prior deproteinization. Ferrozine 137-146 fibrinogen beta chain Homo sapiens 36-46 1568318-0 1992 Elimination of fibrinogen interference in a dye-binding method for iron. Iron 67-71 fibrinogen beta chain Homo sapiens 15-25 1409547-6 1992 Approximately four times greater concentration of KHRR 296-299 AAAA compared with wild-type t-PA was required to consume 50% of the fibrinogen in human plasma. khrr 50-54 fibrinogen beta chain Homo sapiens 132-142 1532403-6 1992 In concentrations equivalent to those that were induced by the highest concentrations of rt-PA evaluated, fibrinogen degradation products potentiated rather than inhibited lysis (p less than or equal to 0.05, n = 4), probably by stimulating rt-PA activity directly. rt-pa 89-94 fibrinogen beta chain Homo sapiens 106-116 1532403-6 1992 In concentrations equivalent to those that were induced by the highest concentrations of rt-PA evaluated, fibrinogen degradation products potentiated rather than inhibited lysis (p less than or equal to 0.05, n = 4), probably by stimulating rt-PA activity directly. rt-pa 241-246 fibrinogen beta chain Homo sapiens 106-116 1347551-7 1992 In a dose-dependent manner (IC50 = 2 nM), NECA inhibited the adherence of FMLP-treated PMN to fibrinogen- but not gelatin-coated plates. Adenosine-5'-(N-ethylcarboxamide) 42-46 fibrinogen beta chain Homo sapiens 94-104 1347551-9 1992 Theophylline (10 microM), an adenosine receptor antagonist, reversed the inhibition by NECA (0.3 microM) of stimulated neutrophil adherence to fibrinogen. Theophylline 0-12 fibrinogen beta chain Homo sapiens 143-153 1347551-9 1992 Theophylline (10 microM), an adenosine receptor antagonist, reversed the inhibition by NECA (0.3 microM) of stimulated neutrophil adherence to fibrinogen. Adenosine-5'-(N-ethylcarboxamide) 87-91 fibrinogen beta chain Homo sapiens 143-153 1557396-1 1992 Fragment D prepared from human fibrinogen was labeled specifically by photoactivation of the peptide [14C]Gly-Pro-Arg-N-(4-azido-2-nitrophenyl)Lys amide. [14c]gly-pro-arg-n-(4-azido-2-nitrophenyl)lys amide 101-152 fibrinogen beta chain Homo sapiens 31-41 1599758-5 1992 In control experiments it was established that the cells maintained at reduced serum concentration, or in serum-free medium without or with fibrinogen are viable even though displaying a lower metabolic rate (ATP formation and DNA synthesis). Adenosine Triphosphate 209-212 fibrinogen beta chain Homo sapiens 140-150 1412183-0 1992 Effects of long-term treatment with warfarin on fibrinogen, FPA, TAT, and D-dimer in patients with coronary artery disease. Warfarin 36-44 fibrinogen beta chain Homo sapiens 48-58 1412183-3 1992 In the warfarin treated group the fibrinogen levels were increased after 9 months, while the levels of TAT, FPA and D-dimer were decreased. Warfarin 7-15 fibrinogen beta chain Homo sapiens 34-44 1344196-5 1992 This aggregation is inhibited by PGE1 and ajoene (an inhibitor of the fibrinogen interaction with the fibrinogen receptor, GPIIb/IIIa). Alprostadil 33-37 fibrinogen beta chain Homo sapiens 70-80 1344196-5 1992 This aggregation is inhibited by PGE1 and ajoene (an inhibitor of the fibrinogen interaction with the fibrinogen receptor, GPIIb/IIIa). Alprostadil 33-37 fibrinogen beta chain Homo sapiens 102-112 1344196-5 1992 This aggregation is inhibited by PGE1 and ajoene (an inhibitor of the fibrinogen interaction with the fibrinogen receptor, GPIIb/IIIa). ajoene 42-48 fibrinogen beta chain Homo sapiens 70-80 1344196-5 1992 This aggregation is inhibited by PGE1 and ajoene (an inhibitor of the fibrinogen interaction with the fibrinogen receptor, GPIIb/IIIa). ajoene 42-48 fibrinogen beta chain Homo sapiens 102-112 1621244-4 1992 In human plasma in the absence of fibrin, the concentrations of both single chain and two-chain JMI-229 rt-PA required to induce 50% fibrinogen degradation in 2 h, were about 15-fold higher than those of Actilyse. rt-pa 104-109 fibrinogen beta chain Homo sapiens 133-143 1540556-6 1992 After 2 weeks of systemic treatment with high dose steroids in patients with GCA the plasma viscosity had returned to normal and was even lower than in controls, and the Hct and fibrinogen had reached normal levels. Steroids 51-59 fibrinogen beta chain Homo sapiens 178-188 1537998-11 1992 At 3 h, fibrinogen levels of less than 1 g/liter were demonstrated with combination therapy (regimen E) as well as with regimen C. Major clinical outcomes including death, reocclusion and reinfarction also showed a tendency to be less common with regimen C. Therefore, although accelerated dose regimens of rt-PA do not reliably yield acute coronary patency rates greater than 85%, an acute coronary patency rate of approximately 85% can be approached. rt-pa 307-312 fibrinogen beta chain Homo sapiens 8-18 1354687-9 1992 Tocopherol also significantly inhibited fibrinogen-induced aggregation of elastase-treated platelets at a concentration of 0.1 mM. Tocopherols 0-10 fibrinogen beta chain Homo sapiens 40-50 1354687-11 1992 The inhibitory effect of the platelet aggregation of tocopherol may be partially accomplished through interference with fibrinogen binding towards its receptor. Tocopherols 53-63 fibrinogen beta chain Homo sapiens 120-130 1312590-2 1992 PMN phagocytosis of rhodamine isothiocyanate-labelled P. gingivalis in the fibrinogen clot was 43 +/- 6% and in the plasma clot was 62 +/- 10%; for P. intermedia the values were 15 +/- 10% and 63 +/- 10%, respectively. rhodamine isothiocyanate 20-44 fibrinogen beta chain Homo sapiens 75-85 1737104-8 1992 Moreover, antibody accessibility to platelet-bound fibrinogen could be restored after Triton X-100 platelet lysis. Octoxynol 86-98 fibrinogen beta chain Homo sapiens 51-61 1733971-2 1992 Prolonged thrombin time was completely corrected by the addition of millimolar concentrations of calcium in a new abnormal fibrinogen, Osaka V. Analysis of lysyl endopeptidase digests of A alpha-, B beta-, or gamma-chains by high performance liquid chromatography, and the following amino acid sequence analysis of relevant peptides revealed that about 50% of the gamma-chain has a replacement of gamma-arginine 375 by glycine. Calcium 97-104 fibrinogen beta chain Homo sapiens 123-133 1739360-5 1992 Fibrinogen levels decreased 15% (0.4 g/L) in tamoxifen-treated subjects at 6 months. Tamoxifen 45-54 fibrinogen beta chain Homo sapiens 0-10 1733971-3 1992 When fibrinogen was digested with plasmin in the presence of millimolar concentration of calcium, the amount of fragment D1 was about 50% of the normal control, and the rest was further cleaved to fragment D2, D3, or D62 with an apparent Mr of 62,000. Calcium 89-96 fibrinogen beta chain Homo sapiens 5-15 1323869-3 1992 The GP IIb/IIIa complex is an adhesion receptor belonging to the integrin superfamily; it can bind five adhesive proteins containing the arginine-glycine-aspartic acid (RGD) sequence in their structure: fibrinogen (Fg), von Willebrand factor (vWf), thrombospondin (Tsp), fibronectin (Fn) and vitronectin (Vn). Aspartic Acid 154-167 fibrinogen beta chain Homo sapiens 203-213 1531588-6 1992 During digestion of fibrinogen at low plasmin concentration, up to 65% of the FpA was cleaved just subsequent to the progressive release of B beta-(1-42)-peptide, and the Arg-16-Gly-17 bond of the A alpha-chain became relatively stable towards plasmin action when present in fragment E (and possibly fragment Y). Arginine 171-174 fibrinogen beta chain Homo sapiens 20-30 1531588-6 1992 During digestion of fibrinogen at low plasmin concentration, up to 65% of the FpA was cleaved just subsequent to the progressive release of B beta-(1-42)-peptide, and the Arg-16-Gly-17 bond of the A alpha-chain became relatively stable towards plasmin action when present in fragment E (and possibly fragment Y). Glycine 178-181 fibrinogen beta chain Homo sapiens 20-30 1576094-3 1992 It is also known that prolonged administration of N-3 fatty acids, ticlopidine, fibrates, pentoxifylline, or alcohol lower plasma fibrinogen levels. Fatty Acids, Omega-3 50-65 fibrinogen beta chain Homo sapiens 130-140 1576094-3 1992 It is also known that prolonged administration of N-3 fatty acids, ticlopidine, fibrates, pentoxifylline, or alcohol lower plasma fibrinogen levels. Ticlopidine 67-78 fibrinogen beta chain Homo sapiens 130-140 1576094-3 1992 It is also known that prolonged administration of N-3 fatty acids, ticlopidine, fibrates, pentoxifylline, or alcohol lower plasma fibrinogen levels. Fibric Acids 80-88 fibrinogen beta chain Homo sapiens 130-140 1576094-3 1992 It is also known that prolonged administration of N-3 fatty acids, ticlopidine, fibrates, pentoxifylline, or alcohol lower plasma fibrinogen levels. Pentoxifylline 90-104 fibrinogen beta chain Homo sapiens 130-140 1572388-4 1992 Formaldehyde (33 microM) for 10 min at 23 degrees C attached 58 fibrinogen molecules per erythrocyte. Formaldehyde 0-12 fibrinogen beta chain Homo sapiens 64-74 1569115-0 1992 Platelet adherence and detachment with adsorbed fibrinogen: a flow study with a series of hydroxyethyl methacrylate-ethyl methacrylate copolymers using video microscopy. hydroxyethyl methacrylate-ethyl methacrylate 90-145 fibrinogen beta chain Homo sapiens 48-58 1616632-2 1992 After the cryogel was solubilized at 37 degrees C, 1:1 complex of fibrinogen and fibronectin was purified at room temperature by affinity chromatography on a gelatin-Sepharose 4B. Sepharose 166-175 fibrinogen beta chain Homo sapiens 66-76 1568519-1 1992 The aim of the double-blind, crossover, placebo-controlled study was to evaluate whether oral administration of sulodexide, a medium molecular weight glycosaminoglycan, had an effect on whole blood, plasma and serum viscosity, and/or plasma fibrinogen concentrations. glucuronyl glucosamine glycan sulfate 112-122 fibrinogen beta chain Homo sapiens 241-251 1568519-3 1992 Orally administered sulodexide had a marked effect on plasma viscosity and on plasma fibrinogen concentrations, whereas there were no effects on whole blood viscosity. glucuronyl glucosamine glycan sulfate 20-30 fibrinogen beta chain Homo sapiens 85-95 1323869-3 1992 The GP IIb/IIIa complex is an adhesion receptor belonging to the integrin superfamily; it can bind five adhesive proteins containing the arginine-glycine-aspartic acid (RGD) sequence in their structure: fibrinogen (Fg), von Willebrand factor (vWf), thrombospondin (Tsp), fibronectin (Fn) and vitronectin (Vn). Arginine 137-145 fibrinogen beta chain Homo sapiens 203-213 1323869-3 1992 The GP IIb/IIIa complex is an adhesion receptor belonging to the integrin superfamily; it can bind five adhesive proteins containing the arginine-glycine-aspartic acid (RGD) sequence in their structure: fibrinogen (Fg), von Willebrand factor (vWf), thrombospondin (Tsp), fibronectin (Fn) and vitronectin (Vn). Arginine 137-145 fibrinogen beta chain Homo sapiens 215-217 1323869-3 1992 The GP IIb/IIIa complex is an adhesion receptor belonging to the integrin superfamily; it can bind five adhesive proteins containing the arginine-glycine-aspartic acid (RGD) sequence in their structure: fibrinogen (Fg), von Willebrand factor (vWf), thrombospondin (Tsp), fibronectin (Fn) and vitronectin (Vn). Glycine 146-153 fibrinogen beta chain Homo sapiens 203-213 1323869-3 1992 The GP IIb/IIIa complex is an adhesion receptor belonging to the integrin superfamily; it can bind five adhesive proteins containing the arginine-glycine-aspartic acid (RGD) sequence in their structure: fibrinogen (Fg), von Willebrand factor (vWf), thrombospondin (Tsp), fibronectin (Fn) and vitronectin (Vn). Glycine 146-153 fibrinogen beta chain Homo sapiens 215-217 1736899-0 1992 Purification and characterization by fast-atom-bombardment mass spectrometry of the polymorphonuclear-leucocyte-elastase-generated A alpha (1-21) fragment of fibrinogen from human blood after incubation with calcium ionophore A23187. Calcium 208-215 fibrinogen beta chain Homo sapiens 158-168 1736899-0 1992 Purification and characterization by fast-atom-bombardment mass spectrometry of the polymorphonuclear-leucocyte-elastase-generated A alpha (1-21) fragment of fibrinogen from human blood after incubation with calcium ionophore A23187. Calcimycin 226-232 fibrinogen beta chain Homo sapiens 158-168 1736899-1 1992 The stimulation of human blood with a Ca2+ ionophore, A23187, leads to activation of polymorphonuclear leucocytes (PMN) with release of small amounts of catalyticaly active elastase, as demonstrated by the formation of a characteristic product, the N-terminal A alpha (1-21) peptide of the Aa subunit of fibrinogen. Calcimycin 54-60 fibrinogen beta chain Homo sapiens 304-314 1315989-2 1992 Since unfractionated heparin was reported to enhance fibrinogen binding to platelets responsible for the hyperaggregating effect of this drug, the purpose of this work was to determine whether or not heparin could also modulate platelet interaction to whole blood clot. Heparin 21-28 fibrinogen beta chain Homo sapiens 53-63 1600034-3 1992 Fibrinogen adsorption from a series of dilute plasma solutions to radio-frequency glow discharge/allylamine, measured using 125I radiolabelled baboon fibrinogen, increased with decreasing plasma dilution to a level much higher than that previously observed on polyurethanes. Allylamine 97-107 fibrinogen beta chain Homo sapiens 0-10 1600034-3 1992 Fibrinogen adsorption from a series of dilute plasma solutions to radio-frequency glow discharge/allylamine, measured using 125I radiolabelled baboon fibrinogen, increased with decreasing plasma dilution to a level much higher than that previously observed on polyurethanes. Allylamine 97-107 fibrinogen beta chain Homo sapiens 150-160 1600034-3 1992 Fibrinogen adsorption from a series of dilute plasma solutions to radio-frequency glow discharge/allylamine, measured using 125I radiolabelled baboon fibrinogen, increased with decreasing plasma dilution to a level much higher than that previously observed on polyurethanes. Polyurethanes 260-273 fibrinogen beta chain Homo sapiens 0-10 1600034-4 1992 Elutability by sodium dodecyl sulphate of fibrinogen adsorbed from dilute plasma also increased with increasing plasma concentration, but fibrinogen preadsorbed from plasma became non-elutable when surfaces were stored in buffer for 5 d before contact with sodium dodecyl sulphate. Sodium Dodecyl Sulfate 15-38 fibrinogen beta chain Homo sapiens 42-52 1600034-11 1992 The plasma preadsorption studies with fibrinogen deficient media suggested that adsorbed fibrinogen is necessary for platelet adhesion to the radio-frequency glow discharge/allylamine substrate at high protein coverage. Allylamine 173-183 fibrinogen beta chain Homo sapiens 89-99 1610956-3 1992 These polymers were shown to delay clotting times in the following ways: by direct complex formation between the polymer and thrombin; by interference with fibrin polymerization; and by complex interactions between polymer, thrombin, plasma antiproteases and fibrinogen in plasma. Polymers 6-14 fibrinogen beta chain Homo sapiens 259-269 1451594-4 1992 When platelets were stimulated with ADP, calcium ionophore A23187, or thrombin, fibrinogen binding to the platelet surface increased markedly. Adenosine Diphosphate 36-39 fibrinogen beta chain Homo sapiens 80-90 1451594-4 1992 When platelets were stimulated with ADP, calcium ionophore A23187, or thrombin, fibrinogen binding to the platelet surface increased markedly. Calcium 41-48 fibrinogen beta chain Homo sapiens 80-90 1451594-4 1992 When platelets were stimulated with ADP, calcium ionophore A23187, or thrombin, fibrinogen binding to the platelet surface increased markedly. Calcimycin 59-65 fibrinogen beta chain Homo sapiens 80-90 1543604-2 1992 The fibrinogen in the glue was prepared by ethanol precipitation of plasma separated from 88 ml of the patient"s blood. Ethanol 43-50 fibrinogen beta chain Homo sapiens 4-14 1419970-2 1992 Preadsorption of a terpolymer of acrylonitrile, poly(ethyleneoxide) methacrylate and trimethylaminoethyl chloride methacrylate leads to very efficient passivation with respect to platelet accumulation and fibrinogen adsorption. terpolymer 19-29 fibrinogen beta chain Homo sapiens 205-215 1419970-2 1992 Preadsorption of a terpolymer of acrylonitrile, poly(ethyleneoxide) methacrylate and trimethylaminoethyl chloride methacrylate leads to very efficient passivation with respect to platelet accumulation and fibrinogen adsorption. Acrylonitrile 33-46 fibrinogen beta chain Homo sapiens 205-215 1419970-2 1992 Preadsorption of a terpolymer of acrylonitrile, poly(ethyleneoxide) methacrylate and trimethylaminoethyl chloride methacrylate leads to very efficient passivation with respect to platelet accumulation and fibrinogen adsorption. poly(ethyleneoxide) methacrylate 48-80 fibrinogen beta chain Homo sapiens 205-215 1419970-2 1992 Preadsorption of a terpolymer of acrylonitrile, poly(ethyleneoxide) methacrylate and trimethylaminoethyl chloride methacrylate leads to very efficient passivation with respect to platelet accumulation and fibrinogen adsorption. trimethylaminoethyl chloride methacrylate 85-126 fibrinogen beta chain Homo sapiens 205-215 1534954-2 1992 Some papers report that the effect of heparin-mediated extracorporeal LDL less than cholesterol, LP(a), triglycerides, fibrinogen greater than precipitation (H.E.L.P.) Heparin 38-45 fibrinogen beta chain Homo sapiens 119-129 1730087-4 1992 The plasminogen-activating potential of rt-PA del(K296-G302) in the presence of CNBr-digested fibrinogen was about twofold lower than that of wild-type rt-PA. rt-pa 40-45 fibrinogen beta chain Homo sapiens 94-104 1731875-2 1992 Measurements of Km for fibrinogen carried out at pH 7.5 and 37 degrees C as a function of NaCl, NaBr, KCl, and KBr concentration, from 50 to 500 mM, show that the derivative d ln Km/d ln a +/-, where a +/- is the mean ion activity, is constant over the entire range of salt concentrations and is strictly dependent on the particular salt present in solution. Sodium Chloride 90-94 fibrinogen beta chain Homo sapiens 23-33 1731875-2 1992 Measurements of Km for fibrinogen carried out at pH 7.5 and 37 degrees C as a function of NaCl, NaBr, KCl, and KBr concentration, from 50 to 500 mM, show that the derivative d ln Km/d ln a +/-, where a +/- is the mean ion activity, is constant over the entire range of salt concentrations and is strictly dependent on the particular salt present in solution. sodium bromide 96-100 fibrinogen beta chain Homo sapiens 23-33 1731875-2 1992 Measurements of Km for fibrinogen carried out at pH 7.5 and 37 degrees C as a function of NaCl, NaBr, KCl, and KBr concentration, from 50 to 500 mM, show that the derivative d ln Km/d ln a +/-, where a +/- is the mean ion activity, is constant over the entire range of salt concentrations and is strictly dependent on the particular salt present in solution. Potassium Chloride 102-105 fibrinogen beta chain Homo sapiens 23-33 1731875-2 1992 Measurements of Km for fibrinogen carried out at pH 7.5 and 37 degrees C as a function of NaCl, NaBr, KCl, and KBr concentration, from 50 to 500 mM, show that the derivative d ln Km/d ln a +/-, where a +/- is the mean ion activity, is constant over the entire range of salt concentrations and is strictly dependent on the particular salt present in solution. Salts 269-273 fibrinogen beta chain Homo sapiens 23-33 1731875-2 1992 Measurements of Km for fibrinogen carried out at pH 7.5 and 37 degrees C as a function of NaCl, NaBr, KCl, and KBr concentration, from 50 to 500 mM, show that the derivative d ln Km/d ln a +/-, where a +/- is the mean ion activity, is constant over the entire range of salt concentrations and is strictly dependent on the particular salt present in solution. Salts 333-337 fibrinogen beta chain Homo sapiens 23-33 1731875-5 1992 The drastic difference in the salt dependence of Km between fibrinogen and the synthetic amide substrate points out that a significant role may be played by the fibrinogen recognition site in the energetics of thrombin-fibrinogen interaction. Amides 89-94 fibrinogen beta chain Homo sapiens 161-171 1731875-5 1992 The drastic difference in the salt dependence of Km between fibrinogen and the synthetic amide substrate points out that a significant role may be played by the fibrinogen recognition site in the energetics of thrombin-fibrinogen interaction. Amides 89-94 fibrinogen beta chain Homo sapiens 161-171 1385983-6 1992 Plasma fibrinogen was observed to play an important role in the adhesion of all three of these species on both the polyethylene oxide-modified and control polyethylene terephthalate materials. Polyethylene Glycols 115-133 fibrinogen beta chain Homo sapiens 7-17 1385983-6 1992 Plasma fibrinogen was observed to play an important role in the adhesion of all three of these species on both the polyethylene oxide-modified and control polyethylene terephthalate materials. Polyethylene Terephthalates 155-181 fibrinogen beta chain Homo sapiens 7-17 1420713-6 1992 Fibrinogen adsorption on the Pluronic-coated surfaces was reduced by more than 95% compared to the adsorption on control surfaces. Poloxamer 29-37 fibrinogen beta chain Homo sapiens 0-10 1420713-9 1992 The presence of 19 ethylene oxide residues in the hydrophilic poly(ethylene oxide) chains was sufficient to repel fibrinogen and platelets by the mechanism of steric repulsion. Ethylene Oxide 19-33 fibrinogen beta chain Homo sapiens 114-124 1420713-9 1992 The presence of 19 ethylene oxide residues in the hydrophilic poly(ethylene oxide) chains was sufficient to repel fibrinogen and platelets by the mechanism of steric repulsion. Polyethylene Glycols 62-82 fibrinogen beta chain Homo sapiens 114-124 1309427-1 1992 Previous studies have shown that binding sites for fibrinogen on platelets stimulated with platelet-activating factor (PAF), adenosine diphosphate or epinephrine rapidly close in the absence of fibrinogen. Adenosine Diphosphate 125-146 fibrinogen beta chain Homo sapiens 51-61 1309427-1 1992 Previous studies have shown that binding sites for fibrinogen on platelets stimulated with platelet-activating factor (PAF), adenosine diphosphate or epinephrine rapidly close in the absence of fibrinogen. Epinephrine 150-161 fibrinogen beta chain Homo sapiens 51-61 1425883-5 1992 Fibrinogen levels after bezafibrate treatment were significantly lowered, the effect being more marked in patients with hyperfibrinogenaemia. Bezafibrate 24-35 fibrinogen beta chain Homo sapiens 0-10 1577834-0 1992 Effect of sulfonation of segmented polyurethanes on the transient adsorption of fibrinogen from plasma: possible correlation with anticoagulant behavior. Polyurethanes 35-48 fibrinogen beta chain Homo sapiens 80-90 1577834-1 1992 The influence of polyurethane sulfonation on fibrinogen adsorption from plasma and on plasma coagulation has been investigated. Polyurethanes 17-29 fibrinogen beta chain Homo sapiens 45-55 1577834-10 1992 Fibrinogen adsorption from plasma to the sulfonated polyurethane surfaces was studied using radioiodine labeling. Polyurethanes 52-64 fibrinogen beta chain Homo sapiens 0-10 1577834-10 1992 Fibrinogen adsorption from plasma to the sulfonated polyurethane surfaces was studied using radioiodine labeling. Iodine-131 92-103 fibrinogen beta chain Homo sapiens 0-10 1577834-11 1992 Fibrinogen surface concentration was found to increase strongly as sulfonate content increased. sulfonate 67-76 fibrinogen beta chain Homo sapiens 0-10 1577834-12 1992 Fibrinogen adsorption behavior is quite different from that of conventional unsulfonated polyurethanes in the sense that the adsorption levels are much higher and there is little displacement of initially adsorbed fibrinogen (Vroman effect). Polyurethanes 89-102 fibrinogen beta chain Homo sapiens 0-10 1577837-14 1992 The distribution of adsorbed fibrinogen molecules indicates that surface-adsorbed fibrinogen may form a two-phase system, containing significant amounts of water. Water 156-161 fibrinogen beta chain Homo sapiens 29-39 1577837-14 1992 The distribution of adsorbed fibrinogen molecules indicates that surface-adsorbed fibrinogen may form a two-phase system, containing significant amounts of water. Water 156-161 fibrinogen beta chain Homo sapiens 82-92 1453503-2 1992 A decrease in whole blood and plasma viscosity, and reductions in hematocrit and fibrinogen were found after one course of treatment with sustained Ligustrazine. tetramethylpyrazine 148-160 fibrinogen beta chain Homo sapiens 81-91 1744509-5 1991 Studies correlating platelet fibrinogen surface expression with the presence of the glycoprotein IIb-IIIa (GPIIb-IIIa) complex showed that in the presence of ethylene glycol tetraacetic acid (EGTA) at 37 degrees C, neither the GPIIb-IIIa complex nor platelet fibrinogen was expressed on the surface of thrombin-activated platelets. glycol tetraacetic acid 167-190 fibrinogen beta chain Homo sapiens 29-39 1387746-0 1992 [The effect of arginine on hydrolysis of fibrinogen by plasmin and mini-plasmin]. Arginine 15-23 fibrinogen beta chain Homo sapiens 41-51 1387746-1 1992 The rate of plasmin or Val442-plasmin catalyzed hydrolysis of fibrinogen decreases several times as affected by arginine in high concentrations. Arginine 112-120 fibrinogen beta chain Homo sapiens 62-72 1782483-2 1991 The glue consists of a solution of concentrated human fibrinogen which is activated by the addition of bovine thrombin and calcium chloride. Calcium Chloride 123-139 fibrinogen beta chain Homo sapiens 54-64 1744509-5 1991 Studies correlating platelet fibrinogen surface expression with the presence of the glycoprotein IIb-IIIa (GPIIb-IIIa) complex showed that in the presence of ethylene glycol tetraacetic acid (EGTA) at 37 degrees C, neither the GPIIb-IIIa complex nor platelet fibrinogen was expressed on the surface of thrombin-activated platelets. Egtazic Acid 192-196 fibrinogen beta chain Homo sapiens 29-39 1744509-5 1991 Studies correlating platelet fibrinogen surface expression with the presence of the glycoprotein IIb-IIIa (GPIIb-IIIa) complex showed that in the presence of ethylene glycol tetraacetic acid (EGTA) at 37 degrees C, neither the GPIIb-IIIa complex nor platelet fibrinogen was expressed on the surface of thrombin-activated platelets. Egtazic Acid 192-196 fibrinogen beta chain Homo sapiens 259-269 1744509-6 1991 Similar experiments performed in the presence of EGTA and calcium showed proportional expression of the GPIIb-IIIa complex and platelet fibrinogen. Egtazic Acid 49-53 fibrinogen beta chain Homo sapiens 136-146 1744509-6 1991 Similar experiments performed in the presence of EGTA and calcium showed proportional expression of the GPIIb-IIIa complex and platelet fibrinogen. Calcium 58-65 fibrinogen beta chain Homo sapiens 136-146 1748719-0 1991 Clustering of erythrocytes by fibrinogen is inhibited by carnitine: evidence that sulfhydryl groups on red blood cell membranes are involved in carnitine actions. Carnitine 144-153 fibrinogen beta chain Homo sapiens 30-40 1748719-3 1991 Incubation or preincubation of red blood cell preparations with carnitine inhibits the aggregation of erythrocytes otherwise elicited by fibrinogen. Carnitine 64-73 fibrinogen beta chain Homo sapiens 137-147 1720019-0 1991 A modified Arg-Asp-Val (RDV) peptide derived during the synthesis of Arg-Glu-Asp-Val (REDV), a tetrapeptide derived from an alternatively spliced site in fibronectin, inhibits the binding of fibrinogen, fibronectin, von Willebrand factor and vitronectin to activated platelets. Arginine 11-14 fibrinogen beta chain Homo sapiens 191-201 1720019-0 1991 A modified Arg-Asp-Val (RDV) peptide derived during the synthesis of Arg-Glu-Asp-Val (REDV), a tetrapeptide derived from an alternatively spliced site in fibronectin, inhibits the binding of fibrinogen, fibronectin, von Willebrand factor and vitronectin to activated platelets. H-Asp-Val-OH 15-22 fibrinogen beta chain Homo sapiens 191-201 2070075-1 1991 The relationship between fibrinogen binding to its receptor and platelet aggregation has been investigated by comparing 125I-fibrinogen binding and aggregation velocities of gel-filtered platelets in the presence of adenosine diphosphate (ADP). Adenosine Diphosphate 216-237 fibrinogen beta chain Homo sapiens 25-35 2070075-1 1991 The relationship between fibrinogen binding to its receptor and platelet aggregation has been investigated by comparing 125I-fibrinogen binding and aggregation velocities of gel-filtered platelets in the presence of adenosine diphosphate (ADP). Adenosine Diphosphate 239-242 fibrinogen beta chain Homo sapiens 25-35 2070075-4 1991 Lowering ADP concentration increases Fmax, in agreement with the modulatory effect of ADP on fibrinogen binding to platelets. Adenosine Diphosphate 9-12 fibrinogen beta chain Homo sapiens 93-103 2070075-4 1991 Lowering ADP concentration increases Fmax, in agreement with the modulatory effect of ADP on fibrinogen binding to platelets. Adenosine Diphosphate 86-89 fibrinogen beta chain Homo sapiens 93-103 2070075-5 1991 Variations of fibrinogen in the range of physiopathologic plasma concentrations affect platelet aggregation induced by any ADP dose. Adenosine Diphosphate 123-126 fibrinogen beta chain Homo sapiens 14-24 1829631-2 1991 In concordance with this finding, supernatants from the patients" fibrin clots caused abnormal enhancement of platelet aggregation, ATP secretion, and binding of 125I-fibrinogen to platelets exposed to subthreshold concentrations of ADP or epinephrine. Adenosine Diphosphate 233-236 fibrinogen beta chain Homo sapiens 167-177 1829631-2 1991 In concordance with this finding, supernatants from the patients" fibrin clots caused abnormal enhancement of platelet aggregation, ATP secretion, and binding of 125I-fibrinogen to platelets exposed to subthreshold concentrations of ADP or epinephrine. Epinephrine 240-251 fibrinogen beta chain Homo sapiens 167-177 1829631-6 1991 Patients" plasmas, as well as purified fibrinogen, showed a prolonged thrombin time (partially corrected by 10 mM CaCl2) and an impaired release of fibrinopeptide A in response to thrombin. Calcium Chloride 114-119 fibrinogen beta chain Homo sapiens 39-49 1829631-8 1991 In addition, the patients" fibrinogen showed normal polymerization of preformed fibrin monomers, normal sialic acid content, and normal binding to ADP or epinephrine-stimulated platelets. N-Acetylneuraminic Acid 104-115 fibrinogen beta chain Homo sapiens 27-37 1829631-8 1991 In addition, the patients" fibrinogen showed normal polymerization of preformed fibrin monomers, normal sialic acid content, and normal binding to ADP or epinephrine-stimulated platelets. Adenosine Diphosphate 147-150 fibrinogen beta chain Homo sapiens 27-37 1829631-8 1991 In addition, the patients" fibrinogen showed normal polymerization of preformed fibrin monomers, normal sialic acid content, and normal binding to ADP or epinephrine-stimulated platelets. Epinephrine 154-165 fibrinogen beta chain Homo sapiens 27-37 1920072-3 1991 Studies of competitive adsorption of proteins, using I125 labelled protein from a mixture of 25 mg% albumin, 15 mg% gamma-globulin and 7.5 mg% fibrinogen indicate an increased adsorption of proteins onto the oxide layer coated surfaces compared to the bare surface. Oxides 208-213 fibrinogen beta chain Homo sapiens 143-153 1647433-4 1991 PMN adhered to fibrinogen in the presence of rTNF alpha could be further stimulated with cytochalasin B and N-formyl-methionyl-leucyl-phenylalanine (FMLP) to release azurophilic granule markers as measured by increasing MPO activity and A alpha(1-21) production over time. Cytochalasin B 89-103 fibrinogen beta chain Homo sapiens 15-25 1712876-0 1991 Role of manganese in MG-63 osteosarcoma cell attachment to fibrinogen and von Willebrand factor. Manganese 8-17 fibrinogen beta chain Homo sapiens 59-95 1880215-0 1991 Lovastatin therapy in hypercholesterolemia: effect on fibrinogen, hemorrheologic parameters, platelet activity, and red blood cell morphology. Lovastatin 0-10 fibrinogen beta chain Homo sapiens 54-64 2045762-10 1991 HCTZ exhibited marginal but significant negative effects on fibrinogen, PV and indices of RBC deformability, but not on RBC aggregation. Hydrochlorothiazide 0-4 fibrinogen beta chain Homo sapiens 60-70 2018974-1 1991 Integrin alpha IIb beta 3 (platelet GPIIb-IIIa) binds fibrinogen via recognition sequences such as Arg-Gly-Asp (RGD). Arginine 99-102 fibrinogen beta chain Homo sapiens 54-64 2018974-1 1991 Integrin alpha IIb beta 3 (platelet GPIIb-IIIa) binds fibrinogen via recognition sequences such as Arg-Gly-Asp (RGD). glycylaspartic acid 103-110 fibrinogen beta chain Homo sapiens 54-64 2035620-5 1991 Our data suggest that different methacrylate polymers induce different changes in adsorbed fibrinogen, which may interfere with its interaction with platelets, and that platelet retention in a methacrylate bead column involves interaction of the COOH-terminal end of the gamma-chain of adsorbed fibrinogen with platelet GpIIb/IIIa receptors. Methacrylates 32-44 fibrinogen beta chain Homo sapiens 91-101 2035620-5 1991 Our data suggest that different methacrylate polymers induce different changes in adsorbed fibrinogen, which may interfere with its interaction with platelets, and that platelet retention in a methacrylate bead column involves interaction of the COOH-terminal end of the gamma-chain of adsorbed fibrinogen with platelet GpIIb/IIIa receptors. Polymers 45-53 fibrinogen beta chain Homo sapiens 91-101 2049463-0 1991 Disseminated intravascular coagulation and decrease in fibrinogen levels induced by vincristine/prednisolone therapy of lymphoid blast crisis of chronic myeloid leukemia. Vincristine 84-95 fibrinogen beta chain Homo sapiens 55-65 2049463-0 1991 Disseminated intravascular coagulation and decrease in fibrinogen levels induced by vincristine/prednisolone therapy of lymphoid blast crisis of chronic myeloid leukemia. Prednisolone 96-108 fibrinogen beta chain Homo sapiens 55-65 2049463-7 1991 In these patients a well-known side effect of long-term steroid therapy, namely a decrease of fibrinogen levels, was observed within the first week of treatment. Steroids 56-63 fibrinogen beta chain Homo sapiens 94-104 2049463-9 1991 We conclude from our results that two types of disturbances in fibrinogen metabolism can be observed during vincristine/prednisolone therapy of LBC of CML: (a) a decrease of fibrinogen levels due to a steroid-mediated impairment of liver synthesis, and (b) a rapid fall in fibrinogen levels in the course of DIC, most likely induced by the release of procoagulants from deteriorating blast cells, leading to severe bleeding in selected cases. Vincristine 108-119 fibrinogen beta chain Homo sapiens 63-73 2049463-9 1991 We conclude from our results that two types of disturbances in fibrinogen metabolism can be observed during vincristine/prednisolone therapy of LBC of CML: (a) a decrease of fibrinogen levels due to a steroid-mediated impairment of liver synthesis, and (b) a rapid fall in fibrinogen levels in the course of DIC, most likely induced by the release of procoagulants from deteriorating blast cells, leading to severe bleeding in selected cases. Vincristine 108-119 fibrinogen beta chain Homo sapiens 174-184 1932138-0 1991 Cytokine production by cholesterol-loaded human peripheral monocyte-macrophages: the effect on fibrinogen mRNA levels in a hepatoma cell-line (HepG2). Cholesterol 23-34 fibrinogen beta chain Homo sapiens 95-105 1680863-8 1991 The binding of 35S-labeled entactin to the immobilized fibrinogen A alpha or B beta chain was concentration-dependent and saturable and could be inhibited by unlabeled entactin, soluble fibrinogen, anti-entactin antiserum, or anti-fibrinogen antiserum. Sulfur-35 15-18 fibrinogen beta chain Homo sapiens 55-65 1680863-8 1991 The binding of 35S-labeled entactin to the immobilized fibrinogen A alpha or B beta chain was concentration-dependent and saturable and could be inhibited by unlabeled entactin, soluble fibrinogen, anti-entactin antiserum, or anti-fibrinogen antiserum. Sulfur-35 15-18 fibrinogen beta chain Homo sapiens 186-196 1680863-8 1991 The binding of 35S-labeled entactin to the immobilized fibrinogen A alpha or B beta chain was concentration-dependent and saturable and could be inhibited by unlabeled entactin, soluble fibrinogen, anti-entactin antiserum, or anti-fibrinogen antiserum. Sulfur-35 15-18 fibrinogen beta chain Homo sapiens 186-196 1759983-4 1991 Fibrinogen (301.4 +/- 71.52 mg/dl) correlated positively with antithrombin III (r = 0.27) and leukocytes (r = 0.25), negatively with HDL-cholesterol (r = 0.18) and tended to increase with smoking. Cholesterol 137-148 fibrinogen beta chain Homo sapiens 0-10 1892842-3 1991 Recombinant fibrinogen containing the gamma" chain incorporated 35SO4 into its chains during biosynthesis, while no incorporation occurred in the protein containing the gamma chain. 35so4 64-69 fibrinogen beta chain Homo sapiens 12-22 1892842-5 1991 In addition, carboxypeptidase Y digestion of the recombinant fibrinogen containing the gamma" chain released 96% of the 35S label from the sulfated chain, and the radioactive material was identified as tyrosine O-sulfate. Sulfur-35 120-123 fibrinogen beta chain Homo sapiens 61-71 1892842-5 1991 In addition, carboxypeptidase Y digestion of the recombinant fibrinogen containing the gamma" chain released 96% of the 35S label from the sulfated chain, and the radioactive material was identified as tyrosine O-sulfate. tyrosine O-sulfate 202-220 fibrinogen beta chain Homo sapiens 61-71 1892842-6 1991 These results clarify previous findings of the sulfation of tyrosine in human fibrinogen. Tyrosine 60-68 fibrinogen beta chain Homo sapiens 78-88 1912561-2 1991 When 0.325-micron diameter beads composed of a hydrophobic polymer, polymethylmethacrylate (PMMA), were added to gel-filtered aequorin-loaded platelets suspended in media containing Ca2+, the platelets aggregated; addition of fibrinogen was not required. Polymethyl Methacrylate 68-90 fibrinogen beta chain Homo sapiens 226-236 1912561-2 1991 When 0.325-micron diameter beads composed of a hydrophobic polymer, polymethylmethacrylate (PMMA), were added to gel-filtered aequorin-loaded platelets suspended in media containing Ca2+, the platelets aggregated; addition of fibrinogen was not required. Polymethyl Methacrylate 92-96 fibrinogen beta chain Homo sapiens 226-236 1912561-5 1991 Monoclonal antibodies (MoAbs) 7E3 and M148 and the synthetic peptides RGDS and fibrinogen gamma chain fragment 400-411, all of which bind to the platelet fibrinogen receptor glycoprotein IIb-IIIa (GPIIb-IIIa) and inhibit fibrinogen binding, prevented PMMA-induced aggregation but did not inhibit the Ca2+ increase. Polymethyl Methacrylate 251-255 fibrinogen beta chain Homo sapiens 79-89 1912561-5 1991 Monoclonal antibodies (MoAbs) 7E3 and M148 and the synthetic peptides RGDS and fibrinogen gamma chain fragment 400-411, all of which bind to the platelet fibrinogen receptor glycoprotein IIb-IIIa (GPIIb-IIIa) and inhibit fibrinogen binding, prevented PMMA-induced aggregation but did not inhibit the Ca2+ increase. Polymethyl Methacrylate 251-255 fibrinogen beta chain Homo sapiens 154-164 1912561-5 1991 Monoclonal antibodies (MoAbs) 7E3 and M148 and the synthetic peptides RGDS and fibrinogen gamma chain fragment 400-411, all of which bind to the platelet fibrinogen receptor glycoprotein IIb-IIIa (GPIIb-IIIa) and inhibit fibrinogen binding, prevented PMMA-induced aggregation but did not inhibit the Ca2+ increase. Polymethyl Methacrylate 251-255 fibrinogen beta chain Homo sapiens 154-164 1912561-7 1991 We conclude that platelets interact initially with PMMA at membrane sites other than those required for fibrinogen binding, leading to activation of membrane phospholipases and PKC, an increase in cytoplasmic Ca2+, release of 5-HT, ADP, and fibrinogen from storage granules, and to platelet aggregation. Polymethyl Methacrylate 51-55 fibrinogen beta chain Homo sapiens 241-251 1912564-18 1991 This abnormal fibrinogen supports adenosine diphosphate-induced platelet aggregation in a normal manner. Adenosine Diphosphate 34-55 fibrinogen beta chain Homo sapiens 14-24 1920361-1 1991 The development of potent antithrombotic agents from the fibrinogen platelet receptor binding sequences Fg-alpha 572-575 -Arg-Gly-Asp-Ser- and Fg-gamma 400-411 -HHLGGAKQAGDV, believed to be a cryptic RGD-type sequence, is described. Arginine 122-125 fibrinogen beta chain Homo sapiens 57-67 1920361-1 1991 The development of potent antithrombotic agents from the fibrinogen platelet receptor binding sequences Fg-alpha 572-575 -Arg-Gly-Asp-Ser- and Fg-gamma 400-411 -HHLGGAKQAGDV, believed to be a cryptic RGD-type sequence, is described. Glycine 126-129 fibrinogen beta chain Homo sapiens 57-67 1920361-1 1991 The development of potent antithrombotic agents from the fibrinogen platelet receptor binding sequences Fg-alpha 572-575 -Arg-Gly-Asp-Ser- and Fg-gamma 400-411 -HHLGGAKQAGDV, believed to be a cryptic RGD-type sequence, is described. Aspartic Acid 130-133 fibrinogen beta chain Homo sapiens 57-67 1920361-1 1991 The development of potent antithrombotic agents from the fibrinogen platelet receptor binding sequences Fg-alpha 572-575 -Arg-Gly-Asp-Ser- and Fg-gamma 400-411 -HHLGGAKQAGDV, believed to be a cryptic RGD-type sequence, is described. Serine 134-137 fibrinogen beta chain Homo sapiens 57-67 1716370-0 1991 The peptide Glu-His-Ile-Pro-Ala binds fibrinogen and inhibits platelet aggregation and adhesion to fibrinogen and vitronectin. Glutamic Acid 12-15 fibrinogen beta chain Homo sapiens 38-48 1716370-0 1991 The peptide Glu-His-Ile-Pro-Ala binds fibrinogen and inhibits platelet aggregation and adhesion to fibrinogen and vitronectin. Glutamic Acid 12-15 fibrinogen beta chain Homo sapiens 99-109 1716370-0 1991 The peptide Glu-His-Ile-Pro-Ala binds fibrinogen and inhibits platelet aggregation and adhesion to fibrinogen and vitronectin. Histidine 16-19 fibrinogen beta chain Homo sapiens 38-48 1716370-0 1991 The peptide Glu-His-Ile-Pro-Ala binds fibrinogen and inhibits platelet aggregation and adhesion to fibrinogen and vitronectin. Histidine 16-19 fibrinogen beta chain Homo sapiens 99-109 1716370-0 1991 The peptide Glu-His-Ile-Pro-Ala binds fibrinogen and inhibits platelet aggregation and adhesion to fibrinogen and vitronectin. Ile-Pro-Ala 20-31 fibrinogen beta chain Homo sapiens 38-48 1716370-0 1991 The peptide Glu-His-Ile-Pro-Ala binds fibrinogen and inhibits platelet aggregation and adhesion to fibrinogen and vitronectin. Ile-Pro-Ala 20-31 fibrinogen beta chain Homo sapiens 99-109 1716370-4 1991 Unlike peptides related to Arg-Gly-Asp-Ser and His-His-Leu-Gly-Gly-Ala-Lys-Gln-Ala-Gly-Asp-Val that bind to the fibrinogen receptor, this peptide binds to fibrinogen. Arginine 27-30 fibrinogen beta chain Homo sapiens 112-122 1716370-4 1991 Unlike peptides related to Arg-Gly-Asp-Ser and His-His-Leu-Gly-Gly-Ala-Lys-Gln-Ala-Gly-Asp-Val that bind to the fibrinogen receptor, this peptide binds to fibrinogen. Glycine 31-34 fibrinogen beta chain Homo sapiens 112-122 1716370-4 1991 Unlike peptides related to Arg-Gly-Asp-Ser and His-His-Leu-Gly-Gly-Ala-Lys-Gln-Ala-Gly-Asp-Val that bind to the fibrinogen receptor, this peptide binds to fibrinogen. Aspartic Acid 35-38 fibrinogen beta chain Homo sapiens 112-122 1716370-4 1991 Unlike peptides related to Arg-Gly-Asp-Ser and His-His-Leu-Gly-Gly-Ala-Lys-Gln-Ala-Gly-Asp-Val that bind to the fibrinogen receptor, this peptide binds to fibrinogen. Histidine 47-50 fibrinogen beta chain Homo sapiens 112-122 1716370-4 1991 Unlike peptides related to Arg-Gly-Asp-Ser and His-His-Leu-Gly-Gly-Ala-Lys-Gln-Ala-Gly-Asp-Val that bind to the fibrinogen receptor, this peptide binds to fibrinogen. Histidine 47-50 fibrinogen beta chain Homo sapiens 155-165 1716370-4 1991 Unlike peptides related to Arg-Gly-Asp-Ser and His-His-Leu-Gly-Gly-Ala-Lys-Gln-Ala-Gly-Asp-Val that bind to the fibrinogen receptor, this peptide binds to fibrinogen. Histidine 51-54 fibrinogen beta chain Homo sapiens 112-122 1716370-4 1991 Unlike peptides related to Arg-Gly-Asp-Ser and His-His-Leu-Gly-Gly-Ala-Lys-Gln-Ala-Gly-Asp-Val that bind to the fibrinogen receptor, this peptide binds to fibrinogen. Histidine 51-54 fibrinogen beta chain Homo sapiens 155-165 1716370-4 1991 Unlike peptides related to Arg-Gly-Asp-Ser and His-His-Leu-Gly-Gly-Ala-Lys-Gln-Ala-Gly-Asp-Val that bind to the fibrinogen receptor, this peptide binds to fibrinogen. Leucine 55-58 fibrinogen beta chain Homo sapiens 112-122 1716370-4 1991 Unlike peptides related to Arg-Gly-Asp-Ser and His-His-Leu-Gly-Gly-Ala-Lys-Gln-Ala-Gly-Asp-Val that bind to the fibrinogen receptor, this peptide binds to fibrinogen. Leucine 55-58 fibrinogen beta chain Homo sapiens 155-165 1716370-4 1991 Unlike peptides related to Arg-Gly-Asp-Ser and His-His-Leu-Gly-Gly-Ala-Lys-Gln-Ala-Gly-Asp-Val that bind to the fibrinogen receptor, this peptide binds to fibrinogen. Glycine 59-62 fibrinogen beta chain Homo sapiens 112-122 1716370-4 1991 Unlike peptides related to Arg-Gly-Asp-Ser and His-His-Leu-Gly-Gly-Ala-Lys-Gln-Ala-Gly-Asp-Val that bind to the fibrinogen receptor, this peptide binds to fibrinogen. Glycine 59-62 fibrinogen beta chain Homo sapiens 155-165 1716370-4 1991 Unlike peptides related to Arg-Gly-Asp-Ser and His-His-Leu-Gly-Gly-Ala-Lys-Gln-Ala-Gly-Asp-Val that bind to the fibrinogen receptor, this peptide binds to fibrinogen. Glycine 59-62 fibrinogen beta chain Homo sapiens 112-122 1716370-4 1991 Unlike peptides related to Arg-Gly-Asp-Ser and His-His-Leu-Gly-Gly-Ala-Lys-Gln-Ala-Gly-Asp-Val that bind to the fibrinogen receptor, this peptide binds to fibrinogen. Glycine 59-62 fibrinogen beta chain Homo sapiens 155-165 1716370-4 1991 Unlike peptides related to Arg-Gly-Asp-Ser and His-His-Leu-Gly-Gly-Ala-Lys-Gln-Ala-Gly-Asp-Val that bind to the fibrinogen receptor, this peptide binds to fibrinogen. Lysine 71-74 fibrinogen beta chain Homo sapiens 112-122 1716370-4 1991 Unlike peptides related to Arg-Gly-Asp-Ser and His-His-Leu-Gly-Gly-Ala-Lys-Gln-Ala-Gly-Asp-Val that bind to the fibrinogen receptor, this peptide binds to fibrinogen. Lysine 71-74 fibrinogen beta chain Homo sapiens 155-165 1716370-4 1991 Unlike peptides related to Arg-Gly-Asp-Ser and His-His-Leu-Gly-Gly-Ala-Lys-Gln-Ala-Gly-Asp-Val that bind to the fibrinogen receptor, this peptide binds to fibrinogen. Alanine 67-70 fibrinogen beta chain Homo sapiens 112-122 1716370-4 1991 Unlike peptides related to Arg-Gly-Asp-Ser and His-His-Leu-Gly-Gly-Ala-Lys-Gln-Ala-Gly-Asp-Val that bind to the fibrinogen receptor, this peptide binds to fibrinogen. Alanine 67-70 fibrinogen beta chain Homo sapiens 155-165 1716370-4 1991 Unlike peptides related to Arg-Gly-Asp-Ser and His-His-Leu-Gly-Gly-Ala-Lys-Gln-Ala-Gly-Asp-Val that bind to the fibrinogen receptor, this peptide binds to fibrinogen. Glycine 59-62 fibrinogen beta chain Homo sapiens 112-122 1716370-4 1991 Unlike peptides related to Arg-Gly-Asp-Ser and His-His-Leu-Gly-Gly-Ala-Lys-Gln-Ala-Gly-Asp-Val that bind to the fibrinogen receptor, this peptide binds to fibrinogen. Glycine 59-62 fibrinogen beta chain Homo sapiens 155-165 1716370-4 1991 Unlike peptides related to Arg-Gly-Asp-Ser and His-His-Leu-Gly-Gly-Ala-Lys-Gln-Ala-Gly-Asp-Val that bind to the fibrinogen receptor, this peptide binds to fibrinogen. Aspartic Acid 87-90 fibrinogen beta chain Homo sapiens 112-122 1716370-4 1991 Unlike peptides related to Arg-Gly-Asp-Ser and His-His-Leu-Gly-Gly-Ala-Lys-Gln-Ala-Gly-Asp-Val that bind to the fibrinogen receptor, this peptide binds to fibrinogen. Valine 91-94 fibrinogen beta chain Homo sapiens 112-122 1716370-6 1991 The resulting peptide (Glu-His-Ile-Pro-Ala) has the characteristics of a fibrinogen binding site mimic: It binds fibrinogen and inhibits both the adhesion of platelets to fibrinogen and platelet aggregation. Glutamic Acid 23-26 fibrinogen beta chain Homo sapiens 73-83 1716370-6 1991 The resulting peptide (Glu-His-Ile-Pro-Ala) has the characteristics of a fibrinogen binding site mimic: It binds fibrinogen and inhibits both the adhesion of platelets to fibrinogen and platelet aggregation. Glutamic Acid 23-26 fibrinogen beta chain Homo sapiens 113-123 1716370-6 1991 The resulting peptide (Glu-His-Ile-Pro-Ala) has the characteristics of a fibrinogen binding site mimic: It binds fibrinogen and inhibits both the adhesion of platelets to fibrinogen and platelet aggregation. Glutamic Acid 23-26 fibrinogen beta chain Homo sapiens 113-123 1716370-6 1991 The resulting peptide (Glu-His-Ile-Pro-Ala) has the characteristics of a fibrinogen binding site mimic: It binds fibrinogen and inhibits both the adhesion of platelets to fibrinogen and platelet aggregation. Histidine 27-30 fibrinogen beta chain Homo sapiens 73-83 1716370-6 1991 The resulting peptide (Glu-His-Ile-Pro-Ala) has the characteristics of a fibrinogen binding site mimic: It binds fibrinogen and inhibits both the adhesion of platelets to fibrinogen and platelet aggregation. Histidine 27-30 fibrinogen beta chain Homo sapiens 113-123 1716370-6 1991 The resulting peptide (Glu-His-Ile-Pro-Ala) has the characteristics of a fibrinogen binding site mimic: It binds fibrinogen and inhibits both the adhesion of platelets to fibrinogen and platelet aggregation. Histidine 27-30 fibrinogen beta chain Homo sapiens 113-123 1716370-6 1991 The resulting peptide (Glu-His-Ile-Pro-Ala) has the characteristics of a fibrinogen binding site mimic: It binds fibrinogen and inhibits both the adhesion of platelets to fibrinogen and platelet aggregation. Proline 35-38 fibrinogen beta chain Homo sapiens 73-83 1716370-6 1991 The resulting peptide (Glu-His-Ile-Pro-Ala) has the characteristics of a fibrinogen binding site mimic: It binds fibrinogen and inhibits both the adhesion of platelets to fibrinogen and platelet aggregation. Proline 35-38 fibrinogen beta chain Homo sapiens 113-123 1716370-6 1991 The resulting peptide (Glu-His-Ile-Pro-Ala) has the characteristics of a fibrinogen binding site mimic: It binds fibrinogen and inhibits both the adhesion of platelets to fibrinogen and platelet aggregation. Proline 35-38 fibrinogen beta chain Homo sapiens 113-123 1716370-6 1991 The resulting peptide (Glu-His-Ile-Pro-Ala) has the characteristics of a fibrinogen binding site mimic: It binds fibrinogen and inhibits both the adhesion of platelets to fibrinogen and platelet aggregation. Alanine 39-42 fibrinogen beta chain Homo sapiens 73-83 1716370-6 1991 The resulting peptide (Glu-His-Ile-Pro-Ala) has the characteristics of a fibrinogen binding site mimic: It binds fibrinogen and inhibits both the adhesion of platelets to fibrinogen and platelet aggregation. Alanine 39-42 fibrinogen beta chain Homo sapiens 113-123 1716370-6 1991 The resulting peptide (Glu-His-Ile-Pro-Ala) has the characteristics of a fibrinogen binding site mimic: It binds fibrinogen and inhibits both the adhesion of platelets to fibrinogen and platelet aggregation. Alanine 39-42 fibrinogen beta chain Homo sapiens 113-123 1839461-3 1991 Activation of diabetic Pg by normal t-PA in the presence of stimulating CNBr fragments of fibrinogen exhibited a prolonged lag phase (30 to 60 minutes) until maximally stimulated plasmin formation occurred (normal, 5 to 15 minutes) and substrate inhibition at Pg concentrations more than 10 to 30 nM. Cyanogen Bromide 72-76 fibrinogen beta chain Homo sapiens 90-100 1839461-3 1991 Activation of diabetic Pg by normal t-PA in the presence of stimulating CNBr fragments of fibrinogen exhibited a prolonged lag phase (30 to 60 minutes) until maximally stimulated plasmin formation occurred (normal, 5 to 15 minutes) and substrate inhibition at Pg concentrations more than 10 to 30 nM. pg 23-25 fibrinogen beta chain Homo sapiens 90-100 1653231-6 1991 Furthermore, when platelets were stimulated by thrombin in the presence of EGTA, AP2, or the synthetic peptide RGDS, to prevent fibrinogen binding to the GPIIb-IIIa complex, open probabilities of the channel currents in these membrane vesicles were also decreased. Egtazic Acid 75-79 fibrinogen beta chain Homo sapiens 128-138 1746004-5 1991 In addition the functional significance of the binding sites was studied by evaluating the response of GFP from the two experimental groups by assessing the effects of increasing concentrations of added fibrinogen on the response to 10 microM ADP using standard light transmission aggregometry. Adenosine Diphosphate 243-246 fibrinogen beta chain Homo sapiens 203-213 1908631-2 1991 Omega-3 fatty acids increase bleeding time; decrease platelet aggregation, blood viscosity, and fibrinogen; and increase erythrocyte deformability, thus decreasing the tendency to thrombus formation. Fatty Acids, Omega-3 0-19 fibrinogen beta chain Homo sapiens 96-106 1934160-7 1991 In contrast, smokers had significantly elevated fibrinogen levels which were positively related to thiocyanate levels, indicating that plasma fibrinogen levels increase in smoking exposure. thiocyanate 99-110 fibrinogen beta chain Homo sapiens 48-58 1934160-7 1991 In contrast, smokers had significantly elevated fibrinogen levels which were positively related to thiocyanate levels, indicating that plasma fibrinogen levels increase in smoking exposure. thiocyanate 99-110 fibrinogen beta chain Homo sapiens 142-152 1889410-6 1991 The different proteolytic events were then correlated with the kinetics of the expression of active fibrinogen binding sites on platelets, as measured through the binding of 125I-labelled purified fibrinogen and to the capacity of CT-treated platelets to aggregate. Iodine-125 174-178 fibrinogen beta chain Homo sapiens 100-110 1889410-6 1991 The different proteolytic events were then correlated with the kinetics of the expression of active fibrinogen binding sites on platelets, as measured through the binding of 125I-labelled purified fibrinogen and to the capacity of CT-treated platelets to aggregate. Carbon Tetrachloride 231-233 fibrinogen beta chain Homo sapiens 100-110 1938292-1 1991 Bovine serum albumin (BSA) and porcine serum fibrinogen (FIB) were multiply labeled with gadolinium3+ by using three different ligands: DTPA dianhydride, isothio-cyanato-benzyl-DTPA (ITCB-DTPA), in which none of the five coordinating carboxylates is employed for macromolecular linkage, and isothiocyanatobenzyl-TRITA, a macrocyclic ligand. gadolinium3+ 89-101 fibrinogen beta chain Homo sapiens 45-55 1938292-1 1991 Bovine serum albumin (BSA) and porcine serum fibrinogen (FIB) were multiply labeled with gadolinium3+ by using three different ligands: DTPA dianhydride, isothio-cyanato-benzyl-DTPA (ITCB-DTPA), in which none of the five coordinating carboxylates is employed for macromolecular linkage, and isothiocyanatobenzyl-TRITA, a macrocyclic ligand. gadolinium3+ 89-101 fibrinogen beta chain Homo sapiens 57-60 1888330-6 1991 Halysin concentration-dependently inhibited the 125I-fibrinogen binding to ADP-stimulated platelets in a competitive manner (IC50 = 0.16 microM). Adenosine Diphosphate 75-78 fibrinogen beta chain Homo sapiens 53-63 1907272-4 1991 Fibrinogen, RGDF peptide, and the fibrinogen phi chain decapeptide LGGAKQAGDV inhibited the binding of AC7 to ADP-stimulated platelets. Adenosine Diphosphate 110-113 fibrinogen beta chain Homo sapiens 34-44 1907272-6 1991 Induction of AC7 binding by D33C, a monoclonal antibody recognizing the GPIIb 426-437 sequence and stimulating fibrinogen binding, indicated that the GPIIb 426-437 and the GPIIIa 109-128 sequences were both involved in a stimulation-dependent conformational modification of the receptor. d33c 28-32 fibrinogen beta chain Homo sapiens 111-121 1768762-1 1991 A congenital fibrinogen variant in a German family is described which has been identified as a substitution of His in position 16 of the A alpha-chain for Arg, manifested over three generations in heterozygous form. Histidine 111-114 fibrinogen beta chain Homo sapiens 13-23 1768762-1 1991 A congenital fibrinogen variant in a German family is described which has been identified as a substitution of His in position 16 of the A alpha-chain for Arg, manifested over three generations in heterozygous form. Arginine 155-158 fibrinogen beta chain Homo sapiens 13-23 1783488-1 1991 Tetrapeptides containing the sequence Arg-Gly-Asp (RGD) antagonize fibrinogen binding to its platelet receptor (gp IIb/IIIa, integrin alpha IIb beta 3) and inhibit platelet aggregation in vitro. arginyl-glycyl-aspartic acid 38-49 fibrinogen beta chain Homo sapiens 67-77 1859363-8 1991 Triflavin inhibited fibrinogen-induced aggregation of human elastase-treated platelets in a dose-dependent manner, indicating that it directly interferes with the binding of fibrinogen to its receptors on platelet membranes exposed by elastase treatment. triflavin 0-9 fibrinogen beta chain Homo sapiens 20-30 1859363-8 1991 Triflavin inhibited fibrinogen-induced aggregation of human elastase-treated platelets in a dose-dependent manner, indicating that it directly interferes with the binding of fibrinogen to its receptors on platelet membranes exposed by elastase treatment. triflavin 0-9 fibrinogen beta chain Homo sapiens 174-184 1859363-9 1991 Additionally, triflavin dose-dependently blocked 125I-labelled fibrinogen binding to ADP-activated platelets. triflavin 14-23 fibrinogen beta chain Homo sapiens 63-73 1859363-9 1991 Additionally, triflavin dose-dependently blocked 125I-labelled fibrinogen binding to ADP-activated platelets. Iodine-125 49-53 fibrinogen beta chain Homo sapiens 63-73 1859363-10 1991 In conclusion, triflavin inhibits platelet aggregation through the blockade of fibrinogen binding to fibrinogen receptors on platelet membranes. triflavin 15-24 fibrinogen beta chain Homo sapiens 79-89 1859363-10 1991 In conclusion, triflavin inhibits platelet aggregation through the blockade of fibrinogen binding to fibrinogen receptors on platelet membranes. triflavin 15-24 fibrinogen beta chain Homo sapiens 101-111 2071611-0 1991 A congenitally abnormal fibrinogen (Vlissingen) with a 6-base deletion in the gamma-chain gene, causing defective calcium binding and impaired fibrin polymerization. Calcium 114-121 fibrinogen beta chain Homo sapiens 24-34 2071611-13 1991 The data indicate that Asn-319 and Asp-320 are crucial for maintaining the integrity of the carboxyl-terminal polymerization sites, the protective effect of Ca2+ ions on plasmin degradation of the carboxyl terminus of the gamma-chain, and the calcium binding domain at the carboxyl terminus of fibrinogen. Asparagine 23-26 fibrinogen beta chain Homo sapiens 294-304 2071611-13 1991 The data indicate that Asn-319 and Asp-320 are crucial for maintaining the integrity of the carboxyl-terminal polymerization sites, the protective effect of Ca2+ ions on plasmin degradation of the carboxyl terminus of the gamma-chain, and the calcium binding domain at the carboxyl terminus of fibrinogen. Aspartic Acid 35-38 fibrinogen beta chain Homo sapiens 294-304 2066708-0 1991 Lovastatin therapy in heterozygous familial hypercholesterolaemic patients: effect on blood rheology and fibrinogen levels. Lovastatin 0-10 fibrinogen beta chain Homo sapiens 105-115 1896962-10 1991 MALL13 stimulation lead to a significant increase in the binding of C1q and C3 to platelets and caused the production of MP to occur more rapidly than it did the exposure of fibrinogen binding sites in the presence of complement. mall13 0-6 fibrinogen beta chain Homo sapiens 174-184 2035681-1 1991 In the presence of extracellular Ca2+, epinephrine induces a rise in cytoplasmic Ca2+ ([Ca2+]i) that is associated with fibrinogen binding to the platelet surface, platelet aggregation, and enhancement of the thrombin-stimulated [Ca2+]i rise and protein phosphorylation. Epinephrine 39-50 fibrinogen beta chain Homo sapiens 120-130 2035681-2 1991 Whether the [Ca2+]i rise induced by epinephrine results from Ca2+ entry associated with fibrinogen binding to its receptor on the platelet surface, the glycoprotein (gp) IIb-IIIa complex, is unknown. Epinephrine 36-47 fibrinogen beta chain Homo sapiens 88-98 2049463-9 1991 We conclude from our results that two types of disturbances in fibrinogen metabolism can be observed during vincristine/prednisolone therapy of LBC of CML: (a) a decrease of fibrinogen levels due to a steroid-mediated impairment of liver synthesis, and (b) a rapid fall in fibrinogen levels in the course of DIC, most likely induced by the release of procoagulants from deteriorating blast cells, leading to severe bleeding in selected cases. Vincristine 108-119 fibrinogen beta chain Homo sapiens 174-184 2049463-9 1991 We conclude from our results that two types of disturbances in fibrinogen metabolism can be observed during vincristine/prednisolone therapy of LBC of CML: (a) a decrease of fibrinogen levels due to a steroid-mediated impairment of liver synthesis, and (b) a rapid fall in fibrinogen levels in the course of DIC, most likely induced by the release of procoagulants from deteriorating blast cells, leading to severe bleeding in selected cases. Prednisolone 120-132 fibrinogen beta chain Homo sapiens 63-73 2049463-9 1991 We conclude from our results that two types of disturbances in fibrinogen metabolism can be observed during vincristine/prednisolone therapy of LBC of CML: (a) a decrease of fibrinogen levels due to a steroid-mediated impairment of liver synthesis, and (b) a rapid fall in fibrinogen levels in the course of DIC, most likely induced by the release of procoagulants from deteriorating blast cells, leading to severe bleeding in selected cases. Prednisolone 120-132 fibrinogen beta chain Homo sapiens 174-184 2049463-9 1991 We conclude from our results that two types of disturbances in fibrinogen metabolism can be observed during vincristine/prednisolone therapy of LBC of CML: (a) a decrease of fibrinogen levels due to a steroid-mediated impairment of liver synthesis, and (b) a rapid fall in fibrinogen levels in the course of DIC, most likely induced by the release of procoagulants from deteriorating blast cells, leading to severe bleeding in selected cases. Prednisolone 120-132 fibrinogen beta chain Homo sapiens 174-184 2049463-9 1991 We conclude from our results that two types of disturbances in fibrinogen metabolism can be observed during vincristine/prednisolone therapy of LBC of CML: (a) a decrease of fibrinogen levels due to a steroid-mediated impairment of liver synthesis, and (b) a rapid fall in fibrinogen levels in the course of DIC, most likely induced by the release of procoagulants from deteriorating blast cells, leading to severe bleeding in selected cases. Steroids 201-208 fibrinogen beta chain Homo sapiens 63-73 1720019-0 1991 A modified Arg-Asp-Val (RDV) peptide derived during the synthesis of Arg-Glu-Asp-Val (REDV), a tetrapeptide derived from an alternatively spliced site in fibronectin, inhibits the binding of fibrinogen, fibronectin, von Willebrand factor and vitronectin to activated platelets. Arginine 69-72 fibrinogen beta chain Homo sapiens 191-201 1720019-0 1991 A modified Arg-Asp-Val (RDV) peptide derived during the synthesis of Arg-Glu-Asp-Val (REDV), a tetrapeptide derived from an alternatively spliced site in fibronectin, inhibits the binding of fibrinogen, fibronectin, von Willebrand factor and vitronectin to activated platelets. H-Asp-Val-OH 77-84 fibrinogen beta chain Homo sapiens 191-201 1926582-0 1991 [Plasminogen activation by a tissue activator and effector properties of fibrinogen-N-terminal disulfide (N-DSK) fibrin complex]. Disulfides 95-104 fibrinogen beta chain Homo sapiens 73-83 1926582-1 1991 Fibrinogen-NDSK complex is a model of protofibril having some features of the fibrin polymer structure. Polymers 85-92 fibrinogen beta chain Homo sapiens 0-10 2057921-4 1991 In alpha 2-AP-depleted plasma 50% clot lysis in 2 h required 2-fold less rscu-PA which was associated with 3-fold more extensive fibrinogen degradation and 2-fold more rtcu-PA generation. rscu-pa 73-80 fibrinogen beta chain Homo sapiens 129-139 1903067-5 1991 When the same assay was conducted with fragment X or fragment D of fibrinogen, the kinetic constants increased 3.2 and 2.9-times, respectively, whereas no enhancement was obtained by fragment E. Neither lysine analogues nor monoclonal antibody toward domains of finger and epidermal growth factor of tPA quench the enhancement by fibrinogen. Lysine 203-209 fibrinogen beta chain Homo sapiens 67-77 2057921-6 1991 In alpha 2-AP-depleted plasma the equipotent rscu-PA concentration was 4-fold lower than in normal plasma and was associated with 3-fold more fibrinogen degradation and a similar extent of rtcu-PA generation. rscu-pa 45-52 fibrinogen beta chain Homo sapiens 142-152 2057923-2 1991 Glycyl-L-prolyl-L-arginyl-L-proline (GPRP) was used to prevent polymerization of released fibrinogen and arginyl-glycyl-aspartyl-serine (RGDS) to block the interaction of released fibrinogen, vWf or fibronectin with the glycoprotein IIb/IIIa complex. glycyl-l-prolyl-l-arginyl-l-proline 0-35 fibrinogen beta chain Homo sapiens 90-100 2057923-2 1991 Glycyl-L-prolyl-L-arginyl-L-proline (GPRP) was used to prevent polymerization of released fibrinogen and arginyl-glycyl-aspartyl-serine (RGDS) to block the interaction of released fibrinogen, vWf or fibronectin with the glycoprotein IIb/IIIa complex. glycyl-l-prolyl-l-arginyl-l-proline 0-35 fibrinogen beta chain Homo sapiens 180-190 2057923-2 1991 Glycyl-L-prolyl-L-arginyl-L-proline (GPRP) was used to prevent polymerization of released fibrinogen and arginyl-glycyl-aspartyl-serine (RGDS) to block the interaction of released fibrinogen, vWf or fibronectin with the glycoprotein IIb/IIIa complex. glycyl-prolyl-arginyl-proline 37-41 fibrinogen beta chain Homo sapiens 90-100 2057923-2 1991 Glycyl-L-prolyl-L-arginyl-L-proline (GPRP) was used to prevent polymerization of released fibrinogen and arginyl-glycyl-aspartyl-serine (RGDS) to block the interaction of released fibrinogen, vWf or fibronectin with the glycoprotein IIb/IIIa complex. glycyl-prolyl-arginyl-proline 37-41 fibrinogen beta chain Homo sapiens 180-190 2012467-8 1991 Finding coronary heart disease with very low cholesterol but elevated fibrinogen levels is consistent with fibrinogen levels being an independent risk factor for coronary heart disease. Cholesterol 45-56 fibrinogen beta chain Homo sapiens 107-117 1859515-0 1991 Decrease of fibrinogen in patients with peripheral atherosclerotic disease by ticlopidine. Ticlopidine 78-89 fibrinogen beta chain Homo sapiens 12-22 1716481-1 1991 In the present study, we systematically investigated aprotinin, epsilon-aminocaproic acid (EACA) and tranexamic acid as inhibitors of fibrinogen breakdown and of the generation of fibrinogen degradation products (FgDP). Aminocaproic Acid 64-89 fibrinogen beta chain Homo sapiens 134-144 1859515-2 1991 It is also known that ticlopidine decreases fibrinogen levels in plasma. Ticlopidine 22-33 fibrinogen beta chain Homo sapiens 44-54 1859515-3 1991 15 PAD patients treated with ticlopidine for 3 months were studied, evaluating the drug"s effect both on maximum walking distance and on fibrinogen. Ticlopidine 29-40 fibrinogen beta chain Homo sapiens 137-147 1859515-6 1991 It is proposed that ticlopidine developing the known effect in decreasing the binding of fibrinogen to platelets induces a decrease only of activated fibrinogen. Ticlopidine 20-31 fibrinogen beta chain Homo sapiens 89-99 1859515-6 1991 It is proposed that ticlopidine developing the known effect in decreasing the binding of fibrinogen to platelets induces a decrease only of activated fibrinogen. Ticlopidine 20-31 fibrinogen beta chain Homo sapiens 150-160 1861090-8 1991 The known favourable effect of Pentoxifylline on red cells and leucocyte function as well as its lowering effect on plasma fibrinogen level, may be responsible for the observed therapeutic effect of Pentoxifylline on venous leg ulcers. Pentoxifylline 199-213 fibrinogen beta chain Homo sapiens 123-133 2010539-3 1991 When blood is collected with trisodium citrate as anticoagulant, which causes a decrease in the levels of external ionized calcium ([Ca2+]o), platelet aggregation can be induced under low shear force (12 dyn/cm2) and is mediated by fibrinogen binding to the glycoprotein IIb-IIIa complex. trisodium citrate 29-46 fibrinogen beta chain Homo sapiens 232-242 2015674-2 1991 The interference seems to be caused by fibrinogen, which, in the presence of heparin, produces an almost constant increase of the measuring signal over the whole range of suitable wavelengths (550 to 700 nm). Heparin 77-84 fibrinogen beta chain Homo sapiens 39-49 2071252-0 1991 Improvement of silent myocardial ischaemia and reduction of plasma fibrinogen during nisoldipine therapy in occult coronary arterial disease. Nisoldipine 85-96 fibrinogen beta chain Homo sapiens 67-77 2071252-8 1991 A significant reduction in plasma fibrinogen was also noted at the end of the nisoldipine phase (P less than 0.001). Nisoldipine 78-89 fibrinogen beta chain Homo sapiens 34-44 1716481-1 1991 In the present study, we systematically investigated aprotinin, epsilon-aminocaproic acid (EACA) and tranexamic acid as inhibitors of fibrinogen breakdown and of the generation of fibrinogen degradation products (FgDP). Aminocaproic Acid 91-95 fibrinogen beta chain Homo sapiens 134-144 1716481-1 1991 In the present study, we systematically investigated aprotinin, epsilon-aminocaproic acid (EACA) and tranexamic acid as inhibitors of fibrinogen breakdown and of the generation of fibrinogen degradation products (FgDP). Tranexamic Acid 101-116 fibrinogen beta chain Homo sapiens 134-144 1849483-3 1991 Two forms of adsorbed fibrinogen are demonstrated on hydrophobic silicone dioxide surfaces: a trinodular about 60 nm long and a globular with about a 40 nm diameter. Silicon Dioxide 65-81 fibrinogen beta chain Homo sapiens 22-32 1649497-4 1991 A significant treatment by time interaction was found only for fibrinogen levels: at two months they were significantly higher in the estradiol group. Estradiol 134-143 fibrinogen beta chain Homo sapiens 63-73 1849483-4 1991 Polymeric networks formed after storage of the surface with adsorbed fibrinogen in PBS for 11 days are also shown. Lead 83-86 fibrinogen beta chain Homo sapiens 69-79 1998652-5 1991 In the multivariate analyses, the following variables showed an independent positive association with plasma fibrinogen level: one social variable (low social class); two psychological variables (abdominal pain index and personal/economic problems); two behavioral variables (smoking and physical inactivity during leisure time); and three physiological variables (low HDL cholesterol, low physical fitness, and high LDL cholesterol). Cholesterol 373-384 fibrinogen beta chain Homo sapiens 109-119 1998652-5 1991 In the multivariate analyses, the following variables showed an independent positive association with plasma fibrinogen level: one social variable (low social class); two psychological variables (abdominal pain index and personal/economic problems); two behavioral variables (smoking and physical inactivity during leisure time); and three physiological variables (low HDL cholesterol, low physical fitness, and high LDL cholesterol). Cholesterol 421-432 fibrinogen beta chain Homo sapiens 109-119 1998652-6 1991 The strongest independent associations with plasma fibrinogen level were found for smoking, social class, LDL cholesterol, and HDL cholesterol. Cholesterol 110-121 fibrinogen beta chain Homo sapiens 51-61 1998652-6 1991 The strongest independent associations with plasma fibrinogen level were found for smoking, social class, LDL cholesterol, and HDL cholesterol. Cholesterol 131-142 fibrinogen beta chain Homo sapiens 51-61 2002277-10 1991 This, then, provides evidence of CIC-mediated impaired GPIIb/IIIa binding to fibrinogen in hemophilia A, HIV-ITP, and SLE. cic 33-36 fibrinogen beta chain Homo sapiens 77-87 2026644-0 1991 The minimum surface fibrinogen concentration necessary for platelet activation on dimethyldichlorosilane-coated glass. dichlorodimethylsilane 82-104 fibrinogen beta chain Homo sapiens 20-30 2026644-1 1991 Albumin and fibrinogen were competitively adsorbed onto dimethyldichlorosilane-coated glass (DDS-glass) and platelet activation was examined as a function of the surface fibrinogen concentration. dichlorodimethylsilane 56-78 fibrinogen beta chain Homo sapiens 12-22 2026644-1 1991 Albumin and fibrinogen were competitively adsorbed onto dimethyldichlorosilane-coated glass (DDS-glass) and platelet activation was examined as a function of the surface fibrinogen concentration. Fumigant 93 93-96 fibrinogen beta chain Homo sapiens 12-22 2002278-1 1991 Inhibition of thrombin proteolysis of fibrinogen with D-phenylalanyl-L-propyl-L-arginine chloromethyl ketone (PPACK) results in irreversible inactivation of the thrombin catalytic site, but the PPACK-inhibited thrombin, through its exosite, retains its ability to bind to fibrinogen or fibrin. d-phenylalanyl-l-propyl-l-arginine chloromethyl ketone 54-108 fibrinogen beta chain Homo sapiens 272-282 2002278-1 1991 Inhibition of thrombin proteolysis of fibrinogen with D-phenylalanyl-L-propyl-L-arginine chloromethyl ketone (PPACK) results in irreversible inactivation of the thrombin catalytic site, but the PPACK-inhibited thrombin, through its exosite, retains its ability to bind to fibrinogen or fibrin. d-phenylalanyl-l-propyl-l-arginine chloromethyl ketone 54-108 fibrinogen beta chain Homo sapiens 38-48 1881558-4 1991 Laboratory monitoring revealed a significant decrease in platelet aggregation and an increase of fibrinogen degradation products only during picotamide treatment. picotamide 141-151 fibrinogen beta chain Homo sapiens 97-107 1899346-7 1991 Both development of EDTA-resistant fibrinogen binding and fibrinogen association with the cytoskeleton were time dependent and reached maxima 45 to 60 minutes after fibrinogen binding to stimulated platelets. Edetic Acid 20-24 fibrinogen beta chain Homo sapiens 35-45 1899346-0 1991 Time-dependent association between platelet-bound fibrinogen and the Triton X-100 insoluble cytoskeleton. Octoxynol 69-81 fibrinogen beta chain Homo sapiens 50-60 1900814-0 1991 Free radical-induced fibrinogen coagulation: modulation of neofibe formation by concentration, pH and temperature. Free Radicals 0-12 fibrinogen beta chain Homo sapiens 21-31 1899346-1 1991 Previous studies indicated a correlation between the formation of EDTA-resistant (irreversible) platelet-fibrinogen interactions and platelet cytoskeleton formation. Edetic Acid 66-70 fibrinogen beta chain Homo sapiens 105-115 1899346-2 1991 The present study explored the direct association of membrane-bound fibrinogen with the Triton X-100 (Sigma Chemical Co, St Louis, MO) insoluble cytoskeleton of aspirin-treated, gel-filtered platelets, activated but not aggregated with 20 mumol/L adenosine diphosphate (ADP) or 150 mU/mL human thrombin (THR) when bound fibrinogen had become resistant to dissociation by EDTA. Octoxynol 88-100 fibrinogen beta chain Homo sapiens 68-78 1899346-2 1991 The present study explored the direct association of membrane-bound fibrinogen with the Triton X-100 (Sigma Chemical Co, St Louis, MO) insoluble cytoskeleton of aspirin-treated, gel-filtered platelets, activated but not aggregated with 20 mumol/L adenosine diphosphate (ADP) or 150 mU/mL human thrombin (THR) when bound fibrinogen had become resistant to dissociation by EDTA. Aspirin 161-168 fibrinogen beta chain Homo sapiens 68-78 1899346-2 1991 The present study explored the direct association of membrane-bound fibrinogen with the Triton X-100 (Sigma Chemical Co, St Louis, MO) insoluble cytoskeleton of aspirin-treated, gel-filtered platelets, activated but not aggregated with 20 mumol/L adenosine diphosphate (ADP) or 150 mU/mL human thrombin (THR) when bound fibrinogen had become resistant to dissociation by EDTA. Adenosine Diphosphate 247-268 fibrinogen beta chain Homo sapiens 68-78 1899346-2 1991 The present study explored the direct association of membrane-bound fibrinogen with the Triton X-100 (Sigma Chemical Co, St Louis, MO) insoluble cytoskeleton of aspirin-treated, gel-filtered platelets, activated but not aggregated with 20 mumol/L adenosine diphosphate (ADP) or 150 mU/mL human thrombin (THR) when bound fibrinogen had become resistant to dissociation by EDTA. Adenosine Diphosphate 270-273 fibrinogen beta chain Homo sapiens 68-78 1899346-2 1991 The present study explored the direct association of membrane-bound fibrinogen with the Triton X-100 (Sigma Chemical Co, St Louis, MO) insoluble cytoskeleton of aspirin-treated, gel-filtered platelets, activated but not aggregated with 20 mumol/L adenosine diphosphate (ADP) or 150 mU/mL human thrombin (THR) when bound fibrinogen had become resistant to dissociation by EDTA. Edetic Acid 371-375 fibrinogen beta chain Homo sapiens 68-78 1899346-3 1991 Conversion of exogenous 125I-fibrinogen to fibrin was prevented by adding Gly-Pro-Arg and neutralizing THR with hirudin before initiating binding studies. glycyl-prolyl-arginine 74-85 fibrinogen beta chain Homo sapiens 29-39 1899346-4 1991 After 60 minutes at 22 degrees C, the cytoskeleton of ADP-treated platelets contained 20% +/- 12% (mean +/- SD, n = 14) of membrane-bound 125I-fibrinogen, representing 10% to 50% of EDTA-resistant fibrinogen binding. Adenosine Diphosphate 54-57 fibrinogen beta chain Homo sapiens 143-153 1899346-4 1991 After 60 minutes at 22 degrees C, the cytoskeleton of ADP-treated platelets contained 20% +/- 12% (mean +/- SD, n = 14) of membrane-bound 125I-fibrinogen, representing 10% to 50% of EDTA-resistant fibrinogen binding. Adenosine Diphosphate 54-57 fibrinogen beta chain Homo sapiens 197-207 1900814-1 1991 The reaction of fibrinogen with Cu(II) (10-100 microM) and ascorbate (0.1-2.0 mM) leads to the formation of an insoluble clot-like material, "neofibe", which is dependent on experimental conditions. cu(ii) 32-38 fibrinogen beta chain Homo sapiens 16-26 1900814-1 1991 The reaction of fibrinogen with Cu(II) (10-100 microM) and ascorbate (0.1-2.0 mM) leads to the formation of an insoluble clot-like material, "neofibe", which is dependent on experimental conditions. Ascorbic Acid 59-68 fibrinogen beta chain Homo sapiens 16-26 1900814-2 1991 The reaction is observed with human and bovine fibrinogen, in the presence of 0.1-0.3 N NaCl, is optimal at the pH range of 7.4-7.7, and has characteristics typical of a site-specific Fenton reaction. Sodium Chloride 88-92 fibrinogen beta chain Homo sapiens 47-57 1864844-5 1991 Triflavin shows about 68% identity of amino acid sequence with trigramin, which is a specific antagonist of the fibrinogen receptor associated with glycoprotein IIb/IIIa complex. triflavin 0-9 fibrinogen beta chain Homo sapiens 112-122 1900814-6 1991 The energy of activation of oxygen utilization by ascorbate and Cu(II) in the absence or presence of fibrinogen is Ea = 6.1 and 7.9 Kcal/mol, respectively. Oxygen 28-34 fibrinogen beta chain Homo sapiens 101-111 1864844-5 1991 Triflavin shows about 68% identity of amino acid sequence with trigramin, which is a specific antagonist of the fibrinogen receptor associated with glycoprotein IIb/IIIa complex. trigramin 63-72 fibrinogen beta chain Homo sapiens 112-122 1864844-9 1991 In conclusion, triflavin specifically binds to fibrinogen receptor associated with GP IIb/IIIa complex and its binding site is located at or near GP IIb/IIIa complex, overlapping with those of 7E3 and another Arg-Gly-Asp-containing polypeptide, rhodostomin. triflavin 15-24 fibrinogen beta chain Homo sapiens 47-57 1900814-6 1991 The energy of activation of oxygen utilization by ascorbate and Cu(II) in the absence or presence of fibrinogen is Ea = 6.1 and 7.9 Kcal/mol, respectively. Ascorbic Acid 50-59 fibrinogen beta chain Homo sapiens 101-111 1864844-9 1991 In conclusion, triflavin specifically binds to fibrinogen receptor associated with GP IIb/IIIa complex and its binding site is located at or near GP IIb/IIIa complex, overlapping with those of 7E3 and another Arg-Gly-Asp-containing polypeptide, rhodostomin. Glycine 213-216 fibrinogen beta chain Homo sapiens 47-57 1900814-6 1991 The energy of activation of oxygen utilization by ascorbate and Cu(II) in the absence or presence of fibrinogen is Ea = 6.1 and 7.9 Kcal/mol, respectively. cu(ii) 64-70 fibrinogen beta chain Homo sapiens 101-111 1864844-9 1991 In conclusion, triflavin specifically binds to fibrinogen receptor associated with GP IIb/IIIa complex and its binding site is located at or near GP IIb/IIIa complex, overlapping with those of 7E3 and another Arg-Gly-Asp-containing polypeptide, rhodostomin. Aspartic Acid 217-220 fibrinogen beta chain Homo sapiens 47-57 1900814-9 1991 The essential requirement for copper, ascorbate and oxygen or hydrogen peroxide, as well as the low efficiency of mannitol as a scavenger, are in accord with the most likely interpretation of these data that fibrinogen undergoes a site-specific Fenton reaction. Copper 30-36 fibrinogen beta chain Homo sapiens 208-218 1900814-9 1991 The essential requirement for copper, ascorbate and oxygen or hydrogen peroxide, as well as the low efficiency of mannitol as a scavenger, are in accord with the most likely interpretation of these data that fibrinogen undergoes a site-specific Fenton reaction. Ascorbic Acid 38-47 fibrinogen beta chain Homo sapiens 208-218 1900814-9 1991 The essential requirement for copper, ascorbate and oxygen or hydrogen peroxide, as well as the low efficiency of mannitol as a scavenger, are in accord with the most likely interpretation of these data that fibrinogen undergoes a site-specific Fenton reaction. Oxygen 52-58 fibrinogen beta chain Homo sapiens 208-218 1900814-9 1991 The essential requirement for copper, ascorbate and oxygen or hydrogen peroxide, as well as the low efficiency of mannitol as a scavenger, are in accord with the most likely interpretation of these data that fibrinogen undergoes a site-specific Fenton reaction. Hydrogen Peroxide 62-79 fibrinogen beta chain Homo sapiens 208-218 1900814-9 1991 The essential requirement for copper, ascorbate and oxygen or hydrogen peroxide, as well as the low efficiency of mannitol as a scavenger, are in accord with the most likely interpretation of these data that fibrinogen undergoes a site-specific Fenton reaction. Mannitol 114-122 fibrinogen beta chain Homo sapiens 208-218 1671533-2 1991 Previously, we identified the C terminus of the gamma chain of fibrinogen as the region of the fibrinogen molecule that contains a ligand for CD11b/CD18 (complement receptor 3) on phorbol ester-stimulated polymorphonuclear leukocytes. Phorbol Esters 180-193 fibrinogen beta chain Homo sapiens 63-73 1671533-2 1991 Previously, we identified the C terminus of the gamma chain of fibrinogen as the region of the fibrinogen molecule that contains a ligand for CD11b/CD18 (complement receptor 3) on phorbol ester-stimulated polymorphonuclear leukocytes. Phorbol Esters 180-193 fibrinogen beta chain Homo sapiens 95-105 1671533-6 1991 Stimulated neutrophils adhere to surfaces coated with the N-terminal disulfide knot fragment of fibrinogen or fibrinogen fragment E. Moreover, peptides containing the sequence Gly-Pro-Arg (which corresponds to amino acids 17-19 of the N-terminal region of the A alpha chain of fibrinogen), and monoclonal antibody LeuM5, block tumor necrosis factor-stimulated neutrophil adhesion to fibrinogen and to the N-terminal disulfide knot fragment of fibrinogen. Disulfides 69-78 fibrinogen beta chain Homo sapiens 96-106 1671533-7 1991 Thus, CD11c/CD18 on tumor necrosis factor-stimulated neutrophils functions as a fibrinogen receptor that recognizes the sequence Gly-Pro-Arg in the N-terminal domain of the A alpha chain of fibrinogen. glycyl-prolyl-arginine 129-140 fibrinogen beta chain Homo sapiens 80-90 1671533-7 1991 Thus, CD11c/CD18 on tumor necrosis factor-stimulated neutrophils functions as a fibrinogen receptor that recognizes the sequence Gly-Pro-Arg in the N-terminal domain of the A alpha chain of fibrinogen. glycyl-prolyl-arginine 129-140 fibrinogen beta chain Homo sapiens 190-200 1665672-1 1991 The interaction of ADP-stimulated human platelets with human 125I-fibrinogen as well as with pig and bovine fibrinogens was analysed. Adenosine Diphosphate 19-22 fibrinogen beta chain Homo sapiens 66-76 1827546-1 1991 The alpha-chain of human fibrinogen was found to be phosphorylated in EDTA-anticoagulated whole blood when trace amounts of (gamma-32P)ATP and 7.5 mM Mg2+ ions were added. Edetic Acid 70-74 fibrinogen beta chain Homo sapiens 25-35 1827546-1 1991 The alpha-chain of human fibrinogen was found to be phosphorylated in EDTA-anticoagulated whole blood when trace amounts of (gamma-32P)ATP and 7.5 mM Mg2+ ions were added. (gamma-32p 124-134 fibrinogen beta chain Homo sapiens 25-35 1827546-1 1991 The alpha-chain of human fibrinogen was found to be phosphorylated in EDTA-anticoagulated whole blood when trace amounts of (gamma-32P)ATP and 7.5 mM Mg2+ ions were added. Adenosine Triphosphate 135-138 fibrinogen beta chain Homo sapiens 25-35 1827546-1 1991 The alpha-chain of human fibrinogen was found to be phosphorylated in EDTA-anticoagulated whole blood when trace amounts of (gamma-32P)ATP and 7.5 mM Mg2+ ions were added. magnesium ion 150-154 fibrinogen beta chain Homo sapiens 25-35 1827546-2 1991 Fibrinogen was not phosphorylated if only the ATP was added. Adenosine Triphosphate 46-49 fibrinogen beta chain Homo sapiens 0-10 1827546-6 1991 Dephosphorylation by alkaline phosphatase removed 50% of the 32P-labelled phosphate from protein kinase A-phosphorylated fibrinogen and over 90% from the casein kinase I or II-phosphorylated fibrinogens. Phosphorus-32 61-64 fibrinogen beta chain Homo sapiens 121-131 1827546-6 1991 Dephosphorylation by alkaline phosphatase removed 50% of the 32P-labelled phosphate from protein kinase A-phosphorylated fibrinogen and over 90% from the casein kinase I or II-phosphorylated fibrinogens. Phosphates 74-83 fibrinogen beta chain Homo sapiens 121-131 2024888-3 1991 Aspirin-insensitive pathways, mediated by protein kinase C and myosin light-chain kinase, lead to a change of platelet shape, with an attendant striking increase in their surface (pseudopods) followed by exposure of receptors for fibrinogen and vWf on GPIIb-IIIa. Aspirin 0-7 fibrinogen beta chain Homo sapiens 230-240 2042443-0 1991 Ticlopidine lowers plasma fibrinogen in patients with polycythaemia rubra vera and additional thrombotic risk factors. Ticlopidine 0-11 fibrinogen beta chain Homo sapiens 26-36 2042443-6 1991 In the ticlopidine group, we recorded a significant 13.14% reduction of the mean fibrinogen level after treatment (390 +/- 63 vs. 449 +/- 97 mg/dl, p less than 0.01). Ticlopidine 7-18 fibrinogen beta chain Homo sapiens 81-91 1711800-11 1991 These data suggest two possible mechanisms to explain the fibrinogen levels: coagulation is activated, followed by an important fibrinolytic reaction elicited by the large amounts of plasminogen and tPA present in the haemothorax liquid. Tetradecanoylphorbol Acetate 199-202 fibrinogen beta chain Homo sapiens 58-68 1933520-8 1991 The only remarkable findings were: a lesser decrease of platelets number per-ECC: a lesser fibrinogen level in postoperative period with Haemaccel. Polygeline 137-146 fibrinogen beta chain Homo sapiens 91-101 15374461-0 1991 Age dependency of the sialic acid content of fibrinogen. N-Acetylneuraminic Acid 22-33 fibrinogen beta chain Homo sapiens 45-55 15374461-4 1991 The higher plasma SA is caused by increasing concentrations of glycoproteins like fibrinogen, but also by a higher content of SA/mg protein, as has been shown for fibrinogen. N-Acetylneuraminic Acid 18-20 fibrinogen beta chain Homo sapiens 82-92 15374461-4 1991 The higher plasma SA is caused by increasing concentrations of glycoproteins like fibrinogen, but also by a higher content of SA/mg protein, as has been shown for fibrinogen. N-Acetylneuraminic Acid 18-20 fibrinogen beta chain Homo sapiens 163-173 15374461-7 1991 An increased red cell aggregation with fibrinogen of healthy elderly correlated with its SA content, but SA is most probably only indicating an altered protein heterogeneity in the aged and not a causative factor that influences erythrocyte aggregation. N-Acetylneuraminic Acid 89-91 fibrinogen beta chain Homo sapiens 39-49 1846526-0 1991 Protein kinase C and cyclic AMP regulate reversible exposure of binding sites for fibrinogen on the glycoprotein IIB-IIIA complex of human platelets. Cyclic AMP 21-31 fibrinogen beta chain Homo sapiens 82-92 1846526-7 1991 We conclude that PAF, ADP and adrenaline regulate exposure of fibrinogen binding sites through a common mechanism consisting of two independent pathways, one dominated by PKC and the other by an as yet unidentified cyclic AMP-sensitive step. Platelet Activating Factor 17-20 fibrinogen beta chain Homo sapiens 62-72 1846526-7 1991 We conclude that PAF, ADP and adrenaline regulate exposure of fibrinogen binding sites through a common mechanism consisting of two independent pathways, one dominated by PKC and the other by an as yet unidentified cyclic AMP-sensitive step. Adenosine Diphosphate 22-25 fibrinogen beta chain Homo sapiens 62-72 1846526-7 1991 We conclude that PAF, ADP and adrenaline regulate exposure of fibrinogen binding sites through a common mechanism consisting of two independent pathways, one dominated by PKC and the other by an as yet unidentified cyclic AMP-sensitive step. Epinephrine 30-40 fibrinogen beta chain Homo sapiens 62-72 1846526-7 1991 We conclude that PAF, ADP and adrenaline regulate exposure of fibrinogen binding sites through a common mechanism consisting of two independent pathways, one dominated by PKC and the other by an as yet unidentified cyclic AMP-sensitive step. Cyclic AMP 215-225 fibrinogen beta chain Homo sapiens 62-72 1893830-0 1991 [The isolation of the NH2-terminal disulfide nodes of human fibrinogen and fibrin and of their constituent polypeptide chain fragments]. Disulfides 35-44 fibrinogen beta chain Homo sapiens 60-70 2004545-5 1991 The results showed that there were statistically significant reductions in plasma and whole blood viscosity and in fibrinogen levels after sulodexide, but not after placebo. glucuronyl glucosamine glycan sulfate 139-149 fibrinogen beta chain Homo sapiens 115-125 2004545-8 1991 It is suggested that the viscosity and fibrinogen reducing effect of sulodexide make it a useful form of treatment in patients with atheromatous vascular diseases of the lower limbs. glucuronyl glucosamine glycan sulfate 69-79 fibrinogen beta chain Homo sapiens 39-49 1686607-7 1991 TGase crosslinking of fibronectin, fibrinogen, and membrane cytoskeletal substrates was associated with substrate degradation and could be inhibited competitively by putrescine. Putrescine 166-176 fibrinogen beta chain Homo sapiens 35-45 2060829-1 1991 Fibrinogen is transformed into insoluble "neofibe" by reaction with up to 100 microM Cu(II) and 1.5 mM ascorbate. cu(ii) 85-91 fibrinogen beta chain Homo sapiens 0-10 2060829-1 1991 Fibrinogen is transformed into insoluble "neofibe" by reaction with up to 100 microM Cu(II) and 1.5 mM ascorbate. Ascorbic Acid 103-112 fibrinogen beta chain Homo sapiens 0-10 2050602-5 1991 In two patients, preoperative anticoagulation with either heparin or nafamostat mesilate was followed by an increase in plasma fibrinogen level from 0.7 to 5.6 g/L and a decrease in FDP from 64 to 8 micrograms/ml in one patient, and fibrinogen from 1.0 to 2.8 g/L and FDP from 40 to 5 micrograms/mL in another patient. Heparin 58-65 fibrinogen beta chain Homo sapiens 127-137 2050602-5 1991 In two patients, preoperative anticoagulation with either heparin or nafamostat mesilate was followed by an increase in plasma fibrinogen level from 0.7 to 5.6 g/L and a decrease in FDP from 64 to 8 micrograms/ml in one patient, and fibrinogen from 1.0 to 2.8 g/L and FDP from 40 to 5 micrograms/mL in another patient. Heparin 58-65 fibrinogen beta chain Homo sapiens 233-243 1938222-3 1991 Plasma fibrinogen level after haemodialysis was significantly lower after administration of heparin alone as compared with the group treated by prostacyclin-heparin infusion. Heparin 92-99 fibrinogen beta chain Homo sapiens 7-17 2050602-5 1991 In two patients, preoperative anticoagulation with either heparin or nafamostat mesilate was followed by an increase in plasma fibrinogen level from 0.7 to 5.6 g/L and a decrease in FDP from 64 to 8 micrograms/ml in one patient, and fibrinogen from 1.0 to 2.8 g/L and FDP from 40 to 5 micrograms/mL in another patient. nafamostat 69-79 fibrinogen beta chain Homo sapiens 127-137 2050602-5 1991 In two patients, preoperative anticoagulation with either heparin or nafamostat mesilate was followed by an increase in plasma fibrinogen level from 0.7 to 5.6 g/L and a decrease in FDP from 64 to 8 micrograms/ml in one patient, and fibrinogen from 1.0 to 2.8 g/L and FDP from 40 to 5 micrograms/mL in another patient. nafamostat 69-79 fibrinogen beta chain Homo sapiens 233-243 1938222-3 1991 Plasma fibrinogen level after haemodialysis was significantly lower after administration of heparin alone as compared with the group treated by prostacyclin-heparin infusion. prostacyclin-heparin 144-164 fibrinogen beta chain Homo sapiens 7-17 1987144-5 1991 Fibrinogen binding to bacterial cells occurred at 4, 22, and 37 degrees C. A functional fibrinogen-binding component (Mr, 150,000) was identified when sodium dodecyl sulfate-solubilized bacteria were fractionated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis, transferred to nitrocellulose membranes, and probed with 125I-fibrinogen. Sodium Dodecyl Sulfate 151-173 fibrinogen beta chain Homo sapiens 0-10 1786245-3 1991 With the use of antibodies it was demonstrated and confirmed that immunologically detectable plasma protein antigens appear and disappear in a time- and concentration-dependent sequence [IgG followed by fibrinogen followed by high-molecular weight kininogen (HMWK)] on silica surfaces. Silicon Dioxide 269-275 fibrinogen beta chain Homo sapiens 203-213 1854685-6 1991 The intrinsic rate of displacement of fibrinogen (due to the Vroman effect) at high shear rates was about ten times faster from glass than from polyethylene based on data taken 5 min after the experiment started. Polyethylene 144-156 fibrinogen beta chain Homo sapiens 38-48 2019612-13 1991 It is hypothesized that specific interactions occur between fibrinogen and sulfonate groups. sulfonate 75-84 fibrinogen beta chain Homo sapiens 60-70 1880691-0 1991 Interaction of poly(L-lysine-alt-terephthalic acid) microcapsules with fibrinogen. poly(N(alpha),N(epsilon)-L-lysinediylterephthaloyl) 15-51 fibrinogen beta chain Homo sapiens 71-81 1880691-1 1991 Interaction of poly(L-lysine-alt-terephthalic acid) microcapsules with fibrinogen was investigated by measuring the degree of microcapsule disintegration, fibrinogen adsorption to microcapsules, and the zeta potential of microcapsules as a function of fibrinogen concentration in phosphate buffer solutions of pH 7.4 at different ionic strengths. poly(N(alpha),N(epsilon)-L-lysinediylterephthaloyl) 15-51 fibrinogen beta chain Homo sapiens 71-81 1880691-1 1991 Interaction of poly(L-lysine-alt-terephthalic acid) microcapsules with fibrinogen was investigated by measuring the degree of microcapsule disintegration, fibrinogen adsorption to microcapsules, and the zeta potential of microcapsules as a function of fibrinogen concentration in phosphate buffer solutions of pH 7.4 at different ionic strengths. poly(N(alpha),N(epsilon)-L-lysinediylterephthaloyl) 15-51 fibrinogen beta chain Homo sapiens 155-165 1880691-1 1991 Interaction of poly(L-lysine-alt-terephthalic acid) microcapsules with fibrinogen was investigated by measuring the degree of microcapsule disintegration, fibrinogen adsorption to microcapsules, and the zeta potential of microcapsules as a function of fibrinogen concentration in phosphate buffer solutions of pH 7.4 at different ionic strengths. poly(N(alpha),N(epsilon)-L-lysinediylterephthaloyl) 15-51 fibrinogen beta chain Homo sapiens 155-165 1880691-1 1991 Interaction of poly(L-lysine-alt-terephthalic acid) microcapsules with fibrinogen was investigated by measuring the degree of microcapsule disintegration, fibrinogen adsorption to microcapsules, and the zeta potential of microcapsules as a function of fibrinogen concentration in phosphate buffer solutions of pH 7.4 at different ionic strengths. Phosphates 280-289 fibrinogen beta chain Homo sapiens 71-81 1987144-5 1991 Fibrinogen binding to bacterial cells occurred at 4, 22, and 37 degrees C. A functional fibrinogen-binding component (Mr, 150,000) was identified when sodium dodecyl sulfate-solubilized bacteria were fractionated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis, transferred to nitrocellulose membranes, and probed with 125I-fibrinogen. Sodium Dodecyl Sulfate 151-173 fibrinogen beta chain Homo sapiens 88-98 1987144-5 1991 Fibrinogen binding to bacterial cells occurred at 4, 22, and 37 degrees C. A functional fibrinogen-binding component (Mr, 150,000) was identified when sodium dodecyl sulfate-solubilized bacteria were fractionated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis, transferred to nitrocellulose membranes, and probed with 125I-fibrinogen. Sodium Dodecyl Sulfate 216-238 fibrinogen beta chain Homo sapiens 88-98 1987144-5 1991 Fibrinogen binding to bacterial cells occurred at 4, 22, and 37 degrees C. A functional fibrinogen-binding component (Mr, 150,000) was identified when sodium dodecyl sulfate-solubilized bacteria were fractionated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis, transferred to nitrocellulose membranes, and probed with 125I-fibrinogen. polyacrylamide 239-253 fibrinogen beta chain Homo sapiens 0-10 1987144-5 1991 Fibrinogen binding to bacterial cells occurred at 4, 22, and 37 degrees C. A functional fibrinogen-binding component (Mr, 150,000) was identified when sodium dodecyl sulfate-solubilized bacteria were fractionated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis, transferred to nitrocellulose membranes, and probed with 125I-fibrinogen. polyacrylamide 239-253 fibrinogen beta chain Homo sapiens 88-98 1987144-7 1991 Two major fibrinogen-degrading components (Mr, 120,000 and 150,000) have been identified by sodium dodecyl sulfate-polyacrylamide gel electrophoresis in substrate-containing gels. Sodium Dodecyl Sulfate 92-114 fibrinogen beta chain Homo sapiens 10-20 1987144-7 1991 Two major fibrinogen-degrading components (Mr, 120,000 and 150,000) have been identified by sodium dodecyl sulfate-polyacrylamide gel electrophoresis in substrate-containing gels. polyacrylamide 115-129 fibrinogen beta chain Homo sapiens 10-20 1987144-8 1991 Fibrinogen degradation by the Mr-120,000 and -150,000 proteases was enhanced by reducing agents, completely inhibited by N-alpha-p-tosyl-L-lysyl chloromethyl ketone, and partially inhibited by n-ethyl maleimide, suggesting that these enzymes are thiol-dependent proteases with trypsinlike substrate specificity. n-alpha-p-tosyl-l-lysyl chloromethyl ketone 121-164 fibrinogen beta chain Homo sapiens 0-10 1987144-8 1991 Fibrinogen degradation by the Mr-120,000 and -150,000 proteases was enhanced by reducing agents, completely inhibited by N-alpha-p-tosyl-L-lysyl chloromethyl ketone, and partially inhibited by n-ethyl maleimide, suggesting that these enzymes are thiol-dependent proteases with trypsinlike substrate specificity. Ethylmaleimide 193-210 fibrinogen beta chain Homo sapiens 0-10 1987144-9 1991 The fibrinogen-binding component could be separated from the fibrinogen-degrading components by selective solubilization of bacteria in sodium deoxycholate. Deoxycholic Acid 136-155 fibrinogen beta chain Homo sapiens 4-14 1803325-3 1991 We discuss, in this review, how ADP induces the characteristic functional responses of platelets, namely shape change, induction and exposure of the fibrinogen binding sites on the GP IIb-IIIa complex, fibrinogen binding to its receptor and platelet aggregation, and the intracellular biochemical events underlying these functions. Adenosine Diphosphate 32-35 fibrinogen beta chain Homo sapiens 149-159 1803325-3 1991 We discuss, in this review, how ADP induces the characteristic functional responses of platelets, namely shape change, induction and exposure of the fibrinogen binding sites on the GP IIb-IIIa complex, fibrinogen binding to its receptor and platelet aggregation, and the intracellular biochemical events underlying these functions. Adenosine Diphosphate 32-35 fibrinogen beta chain Homo sapiens 202-212 1948093-0 1991 Low-dose intermittent heparin therapy decreases plasma fibrinogen levels. Heparin 22-29 fibrinogen beta chain Homo sapiens 55-65 1858340-1 1991 Simple procedure was developed for production of fibrinogen concentrate from small amounts of human autogenous blood using precipitation with polyethylene glycol and ammonium sulfate. Polyethylene Glycols 142-161 fibrinogen beta chain Homo sapiens 49-59 1858340-1 1991 Simple procedure was developed for production of fibrinogen concentrate from small amounts of human autogenous blood using precipitation with polyethylene glycol and ammonium sulfate. Ammonium Sulfate 166-182 fibrinogen beta chain Homo sapiens 49-59 1858340-2 1991 Maximal yield of fibrinogen was obtained using polyethylene glycol 2,000 and 6,000 daltons at concentrations 7% and 4.5%, respectively. Polyethylene Glycols 47-66 fibrinogen beta chain Homo sapiens 17-27 1858340-4 1991 Sigma-Aminocapronic acid and contrical should be added during bloodletting as well as into blood plasma before isolation of fibrinogen to avoid possible fibrinogen proteolysis. aminocapronic acid 6-24 fibrinogen beta chain Homo sapiens 153-163 2129320-7 1990 Pravastatin, but not cholestyramine, caused a significant fall in plasma viscosity and fibrinogen, but no change was seen in whole blood rheology. Pravastatin 0-11 fibrinogen beta chain Homo sapiens 87-97 2174048-8 1990 Lysine and epsilon-aminocaproic acid could inhibit the binding of plasminogens and plasminogen derivatives with fibrin and block the enhancement effect of fibrinogen degradation products on plasminogen activation. Lysine 0-6 fibrinogen beta chain Homo sapiens 155-165 2174048-8 1990 Lysine and epsilon-aminocaproic acid could inhibit the binding of plasminogens and plasminogen derivatives with fibrin and block the enhancement effect of fibrinogen degradation products on plasminogen activation. Aminocaproic Acid 11-36 fibrinogen beta chain Homo sapiens 155-165 2172242-0 1990 Inhibition of fibrinogen binding to human platelets by S-nitroso-N-acetylcysteine. S-nitroso-N-acetylcysteine 55-81 fibrinogen beta chain Homo sapiens 14-24 2172242-2 1990 We found that SNOAC markedly inhibited the binding of fibrinogen to normal human platelets in a dose-dependent fashion and that this inhibitory effect was the result of both an increase in the apparent Kd of the platelet receptor for the fibrinogen molecule (from 6.8 x 10(-7) to 1.8 x 10(-6) M, a 2.7-fold increase) and a decrease in the total number of fibrinogen molecules bound to the platelet (from 76,200 to 38,250, a 50% decrease). S-nitroso-N-acetylcysteine 14-19 fibrinogen beta chain Homo sapiens 54-64 2172242-2 1990 We found that SNOAC markedly inhibited the binding of fibrinogen to normal human platelets in a dose-dependent fashion and that this inhibitory effect was the result of both an increase in the apparent Kd of the platelet receptor for the fibrinogen molecule (from 6.8 x 10(-7) to 1.8 x 10(-6) M, a 2.7-fold increase) and a decrease in the total number of fibrinogen molecules bound to the platelet (from 76,200 to 38,250, a 50% decrease). S-nitroso-N-acetylcysteine 14-19 fibrinogen beta chain Homo sapiens 238-248 1846014-9 1991 In contrast to the superoxide specific tests we found an inhibitory effect of fibrinogen and also serum compared to FDP-D using chemiluminescence. Superoxides 19-29 fibrinogen beta chain Homo sapiens 78-88 2077911-4 1990 Staphylococcus agglutination and ethanol tests revealed a significant increase in early PDF and other constituents of the fibrinogen pool. Ethanol 33-40 fibrinogen beta chain Homo sapiens 122-132 2261348-1 1990 Platelet fibrinogen binding in whole blood has been measured in vitro by flow cytometry using a commercially available, fluorescein isothiocyanate (FITC)-conjugated polyclonal antifibrinogen antibody. Fluorescein-5-isothiocyanate 120-146 fibrinogen beta chain Homo sapiens 9-19 2261348-1 1990 Platelet fibrinogen binding in whole blood has been measured in vitro by flow cytometry using a commercially available, fluorescein isothiocyanate (FITC)-conjugated polyclonal antifibrinogen antibody. Fluorescein-5-isothiocyanate 148-152 fibrinogen beta chain Homo sapiens 9-19 2261348-4 1990 Half-maximal fibrinogen binding occurred at about 0.4 microM ADP, and ADP-induced fibrinogen binding continued progressively during 20 min incubation with 10 microM ADP. Adenosine Diphosphate 61-64 fibrinogen beta chain Homo sapiens 13-23 2261348-4 1990 Half-maximal fibrinogen binding occurred at about 0.4 microM ADP, and ADP-induced fibrinogen binding continued progressively during 20 min incubation with 10 microM ADP. Adenosine Diphosphate 70-73 fibrinogen beta chain Homo sapiens 82-92 2261348-4 1990 Half-maximal fibrinogen binding occurred at about 0.4 microM ADP, and ADP-induced fibrinogen binding continued progressively during 20 min incubation with 10 microM ADP. Adenosine Diphosphate 70-73 fibrinogen beta chain Homo sapiens 82-92 2148136-4 1990 The percent glycosylated fibrinogen exhibited significant association with severity of hyperglycaemia when diabetic patients were divided by 2, 4, and 6 standard deviations above the mean of fasting plasma glucose of non-diabetic subjects. Glucose 206-213 fibrinogen beta chain Homo sapiens 25-35 2172242-2 1990 We found that SNOAC markedly inhibited the binding of fibrinogen to normal human platelets in a dose-dependent fashion and that this inhibitory effect was the result of both an increase in the apparent Kd of the platelet receptor for the fibrinogen molecule (from 6.8 x 10(-7) to 1.8 x 10(-6) M, a 2.7-fold increase) and a decrease in the total number of fibrinogen molecules bound to the platelet (from 76,200 to 38,250, a 50% decrease). S-nitroso-N-acetylcysteine 14-19 fibrinogen beta chain Homo sapiens 238-248 2172242-5 1990 These results describe the inhibition of platelet fibrinogen binding by an S-nitrosothiol compound, help define the biochemical mechanism by which S-nitrosothiols inhibit platelet aggregation, and lend support to the view that cyclic GMP is an important inhibitory intracellular mediator in human platelets. S-Nitrosothiols 75-89 fibrinogen beta chain Homo sapiens 50-60 2172242-5 1990 These results describe the inhibition of platelet fibrinogen binding by an S-nitrosothiol compound, help define the biochemical mechanism by which S-nitrosothiols inhibit platelet aggregation, and lend support to the view that cyclic GMP is an important inhibitory intracellular mediator in human platelets. S-Nitrosothiols 147-162 fibrinogen beta chain Homo sapiens 50-60 2275224-1 1990 In 1985, investigators reported that four months of pentoxifylline therapy resulted in a significant decrease in proteinuria (46 percent reduction) and plasma fibrinogen concentrations (18 percent reduction) in patients with diabetes. Pentoxifylline 52-66 fibrinogen beta chain Homo sapiens 159-169 2226821-3 1990 Fluorescence studies indicated changes in the tertiary structure around tryptophan residues for protein kinase A- or C-phosphorylated fibrinogens, but failed to show any such change for fibrinogen phosphorylated by either of the casein kinases. Tryptophan 72-82 fibrinogen beta chain Homo sapiens 134-144 2148136-5 1990 There were significant correlations between glycosylated fibrinogen and fasting plasma glucose (r = 0.83, p less than 0.001), glycosylated haemoglobin (r = 0.94, p less than 0.001) and glycosylated albumin (r = 0.92, p less than 0.001) for all subjects studied. Glucose 87-94 fibrinogen beta chain Homo sapiens 57-67 2148136-7 1990 It is suggested that glycosylated fibrinogen provides the clinician with earlier objective evidence of the metabolic response to therapeutic intervention, and might be regarded as a short-term (2-3 days) index of blood glucose control. Blood Glucose 213-226 fibrinogen beta chain Homo sapiens 34-44 2133225-1 1990 Inhibition of thrombin proteolysis of fibrinogen with D-phenylalanyl-L-propyl-L-arginine chloromethyl ketone (PPACK) results in irreversible inactivation of the thrombin catalytic site, but the PPACK-inhibited thrombin, through its exosite, retains its ability to bind to fibrinogen or fibrin. d-phenylalanyl-l-propyl-l-arginine chloromethyl ketone 54-108 fibrinogen beta chain Homo sapiens 272-282 2211716-4 1990 In contrast to this increased peptide binding of GPIIb/IIIa, Mn2+ reduces the binding of GPIIb/IIIa to its macromolecular RGD-containing ligands fibrinogen, fibronectin, and vitronectin. Manganese(2+) 61-65 fibrinogen beta chain Homo sapiens 145-155 2133213-0 1990 The triggering of fibrinogen receptors on mononuclear phagocytes of healthy subjects and of a thrombasthenia Glanzmann patient promotes the generation of reactive oxygen species. Reactive Oxygen Species 154-177 fibrinogen beta chain Homo sapiens 18-28 2133218-1 1990 In this work, fibrinogen evolution was analysed by testing the reactivity of fibrinogen from different species with monoclonal antibodies against human fibrinogen fragment D. One epitope concerning the fibrin polymerization site "a" and two epitopes responsible for tPA binding to fibrin were conserved in all mammalian fibrogens tested but not in crab coagulogen or pleurodella fibrinogen. Tetradecanoylphorbol Acetate 266-269 fibrinogen beta chain Homo sapiens 14-24 2133225-1 1990 Inhibition of thrombin proteolysis of fibrinogen with D-phenylalanyl-L-propyl-L-arginine chloromethyl ketone (PPACK) results in irreversible inactivation of the thrombin catalytic site, but the PPACK-inhibited thrombin, through its exosite, retains its ability to bind to fibrinogen or fibrin. d-phenylalanyl-l-propyl-l-arginine chloromethyl ketone 54-108 fibrinogen beta chain Homo sapiens 38-48 2257170-6 1990 Fibrinogen fragment D binding proteins were identified using a dithiothreitol-iodoacetamide extract of the fungus. dithiothreitol-iodoacetamide 63-91 fibrinogen beta chain Homo sapiens 0-10 2229822-2 1990 This enzyme can rapidly inactivate fibrinogen and, as a complex with heparin, may prevent coagulation that may otherwise occur when plasma enters tissues at sites of immediate reactions. Heparin 69-76 fibrinogen beta chain Homo sapiens 35-45 2283349-0 1990 Postadsorptive transitions in fibrinogen: influence of polymer properties. Polymers 55-62 fibrinogen beta chain Homo sapiens 30-40 2283349-4 1990 In this study, we have examined the effects of polymer structure and composition, chain mobility, and hydrophobicity on the postadsorptive transitions of fibrinogen. Polymers 47-54 fibrinogen beta chain Homo sapiens 154-164 2283349-5 1990 Glassy, rigid polymers showed high fibrinogen adsorption, regardless of whether the polymer was hydrophilic or hydrophobic. Polymers 14-22 fibrinogen beta chain Homo sapiens 35-45 2283349-5 1990 Glassy, rigid polymers showed high fibrinogen adsorption, regardless of whether the polymer was hydrophilic or hydrophobic. Polymers 14-21 fibrinogen beta chain Homo sapiens 35-45 2172648-11 1990 Similarly, when forskolin was added to ECs spread on vitronectin or on fibrinogen, there was a progressive but reversible disruption of actin microfilaments and diffusion of beta 3 receptors. Colforsin 16-25 fibrinogen beta chain Homo sapiens 71-81 2215252-6 1990 When all subjects were pooled for the analyses, both fibrinogen and PAI-1 levels correlated positively with glucose and insulin levels. Glucose 108-115 fibrinogen beta chain Homo sapiens 53-63 2271566-2 1990 A 38K, equine CNBr fragment that reacts with this antiserum was isolated from CNBr-digested equine fibrinogen by Sephadex G-100 gel filtration. sephadex 113-127 fibrinogen beta chain Homo sapiens 99-109 2289632-11 1990 Following the signal sequence is a region of highly conserved amino acids that participate in disulfide bond formation critical for the maintenance of tertiary structure in mammalian fibrinogen. Disulfides 94-103 fibrinogen beta chain Homo sapiens 183-193 2389702-6 1990 There was a rise in fibrinogen values throughout the range of blood sugar levels, which suggests a thrombogenic explanation for the unique diabetic effect. Blood Glucose 62-73 fibrinogen beta chain Homo sapiens 20-30 1687968-1 1991 The production of O2- in response to LPS, PAF, FMLP, TNF and PMA by human neutrophils in suspension and residing on surfaces coated with fetal calf serum (FCS), fibronectin (FN), laminin (LM), collagen types I and IV (CI and CIV), fibrinogen (FBG) or fibrin (FBN) was studied. Oxygen 18-20 fibrinogen beta chain Homo sapiens 231-241 2264020-3 1990 Two of four antibodies, named P9 and P55, strongly inhibited adenosine diphosphate (ADP)-induced aggregation of washed rat platelets and caused approximately 50% inhibition of human fibrinogen binding to ADP-stimulated rat platelets, suggesting that rat GPIIb/IIIa serves as a fibrinogen receptor in ADP-induced aggregation. Adenosine Diphosphate 204-207 fibrinogen beta chain Homo sapiens 182-192 2264020-3 1990 Two of four antibodies, named P9 and P55, strongly inhibited adenosine diphosphate (ADP)-induced aggregation of washed rat platelets and caused approximately 50% inhibition of human fibrinogen binding to ADP-stimulated rat platelets, suggesting that rat GPIIb/IIIa serves as a fibrinogen receptor in ADP-induced aggregation. Adenosine Diphosphate 204-207 fibrinogen beta chain Homo sapiens 277-287 2264020-3 1990 Two of four antibodies, named P9 and P55, strongly inhibited adenosine diphosphate (ADP)-induced aggregation of washed rat platelets and caused approximately 50% inhibition of human fibrinogen binding to ADP-stimulated rat platelets, suggesting that rat GPIIb/IIIa serves as a fibrinogen receptor in ADP-induced aggregation. Adenosine Diphosphate 204-207 fibrinogen beta chain Homo sapiens 182-192 2264020-3 1990 Two of four antibodies, named P9 and P55, strongly inhibited adenosine diphosphate (ADP)-induced aggregation of washed rat platelets and caused approximately 50% inhibition of human fibrinogen binding to ADP-stimulated rat platelets, suggesting that rat GPIIb/IIIa serves as a fibrinogen receptor in ADP-induced aggregation. Adenosine Diphosphate 204-207 fibrinogen beta chain Homo sapiens 277-287 2133226-1 1990 Pentoxifylline has been reported to induce a decrease in plasma fibrinogen level in patients with arteritis. Pentoxifylline 0-14 fibrinogen beta chain Homo sapiens 64-74 2133226-3 1990 In patients we have confirmed the decrease in plasma fibrinogen level during pentoxifylline therapy, and shown that the decrease is correlated with the improvement of the clinical symptoms, whereas no significant modification was noted in the healthy volunteers taking pentoxifylline. Pentoxifylline 77-91 fibrinogen beta chain Homo sapiens 53-63 2133226-4 1990 Therefore it is suggested that the decrease in fibrinogen induced in patients was due to an indirect mechanism, probably related to the pentoxifylline-induced decrease in TNF synthesis. Pentoxifylline 136-150 fibrinogen beta chain Homo sapiens 47-57 2223628-1 1990 Fibrinogen coupled to colloidal gold (Fgn/Au) has been used to follow GPIIb-IIIa receptors on surface-activated platelets and to evaluate the effects of the anti-actin agent, cytochalasin B (CB), on the movement of receptor-ligand complexes. Cytochalasin B 175-189 fibrinogen beta chain Homo sapiens 0-10 2147637-2 1990 Baseline characteristics of the 17 bezafibrate- and 19 placebo-treated patients were comparable in most respects with the exception of concentrations of fasting serum triglycerides and blood glucose which were lower (NS) and plasma fibrinogen which were higher (p less than 0.05), in those later treated with bezafibrate. Bezafibrate 35-46 fibrinogen beta chain Homo sapiens 232-242 2272752-0 1990 Structure of the fibrinogen binding sequence: arginylglycylaspartic acid (RGD). arginyl-glycyl-aspartic acid 46-72 fibrinogen beta chain Homo sapiens 17-27 2084223-5 1990 It may be important for the mechanism of (1----3)-beta-D-glucan induced enhancement of plasma clotting to activate factor XII, to bind with fibrinogen, and to increase the local concentration of the clotting system by steric exclusion. (1----3)-beta-d-glucan 41-63 fibrinogen beta chain Homo sapiens 140-150 2143188-6 1990 Fragments Dhem were isolated from an intermediate hementin digest of fibrinogen using anion-exchange chromatography. dhem 10-14 fibrinogen beta chain Homo sapiens 69-79 2380171-3 1990 Hirugen, the synthetic N-acetylated COOH-terminal dodecapeptide (Ac-Asn-Gly-Asp-Phe-Glu-Glu-Ile-Pro-Glu-Glu-Tyr(SO3)-Leu) of hirudin was shown in the present study to behave as a pure competitive inhibitor (Ki = 0.54 microM) of human alpha-thrombin-catalyzed release of fibrinopeptide A from human fibrinogen. Nitrogen 23-24 fibrinogen beta chain Homo sapiens 298-308 2380171-3 1990 Hirugen, the synthetic N-acetylated COOH-terminal dodecapeptide (Ac-Asn-Gly-Asp-Phe-Glu-Glu-Ile-Pro-Glu-Glu-Tyr(SO3)-Leu) of hirudin was shown in the present study to behave as a pure competitive inhibitor (Ki = 0.54 microM) of human alpha-thrombin-catalyzed release of fibrinopeptide A from human fibrinogen. ac-asn 65-71 fibrinogen beta chain Homo sapiens 298-308 2380171-3 1990 Hirugen, the synthetic N-acetylated COOH-terminal dodecapeptide (Ac-Asn-Gly-Asp-Phe-Glu-Glu-Ile-Pro-Glu-Glu-Tyr(SO3)-Leu) of hirudin was shown in the present study to behave as a pure competitive inhibitor (Ki = 0.54 microM) of human alpha-thrombin-catalyzed release of fibrinopeptide A from human fibrinogen. Phenylalanine 80-83 fibrinogen beta chain Homo sapiens 298-308 2380171-9 1990 Hirugen, an exosite-directed competitive inhibitor, blocks the interaction of alpha-thrombin with fibrinogen while leaving alpha-thrombin competent to react with AT. exosite 12-19 fibrinogen beta chain Homo sapiens 98-108 2380171-10 1990 Thus, unlike active site-directed competitive inhibitors, hirugen should act in concert with AT and heparin to reduce the amount of fibrinogen that is processed during the lifetime of alpha-thrombin in plasma. Heparin 100-107 fibrinogen beta chain Homo sapiens 132-142 2272752-1 1990 The crystal structure of a tetrahydrated form of L-arginyl-glycyl-L-aspartic acid (RGD), the consensus sequence for binding of fibrinogen to cell surface receptors, has been determined from diffractometer data. arginyl-glycyl-aspartic acid 49-81 fibrinogen beta chain Homo sapiens 127-137 2237813-0 1990 Fibrinogen-containing membrane-associated structures arising at the surfaces of ADP-stimulated blood platelets. Adenosine Diphosphate 80-83 fibrinogen beta chain Homo sapiens 0-10 2203794-5 1990 On hydrophobic polymers like polyethylene, the low amounts of adsorbed fibrinogen and HMW kininogen from plasma and concentrated plasma solutions may be due to a preferential adsorption of HDL. Polymers 15-23 fibrinogen beta chain Homo sapiens 71-81 2203794-5 1990 On hydrophobic polymers like polyethylene, the low amounts of adsorbed fibrinogen and HMW kininogen from plasma and concentrated plasma solutions may be due to a preferential adsorption of HDL. Polyethylene 29-41 fibrinogen beta chain Homo sapiens 71-81 2212394-2 1990 Presented here are the results of a randomized, double-blind, crossover controlled trail that compared the effects of dietary n-3 and n-6 fatty acid supplementation on plasma fibrinogen levels in 10 patients with hyperlipoproteinemia types IIb or IV. n-3 and n-6 fatty acid 126-148 fibrinogen beta chain Homo sapiens 175-185 2212394-6 1990 Unlike previous reports, however, n-6 polyunsaturated fatty acids were also associated with significant reductions in fibrinogen levels. n-6 polyunsaturated fatty acids 34-65 fibrinogen beta chain Homo sapiens 118-128 2143650-1 1990 The kinetics of inhibition of the amidolytic activity of plasmin on D-Val-L-Leu-L-Lys p-nitroanilide hydrochloride (S-2251) by fibrinogen and fibrin were determined. d-val-l-leu-l-lys p-nitroanilide hydrochloride 68-114 fibrinogen beta chain Homo sapiens 127-137 2143650-5 1990 Addition of 0.1 mM-6-aminohexanoic acid shifted the non-linear curve obtained in the presence of fibrinogen to a straight line as for controls, indicating that 6-aminohexanoic acid abolishes the fibrinogen-induced inhibition. Aminocaproic Acid 18-39 fibrinogen beta chain Homo sapiens 97-107 2143650-5 1990 Addition of 0.1 mM-6-aminohexanoic acid shifted the non-linear curve obtained in the presence of fibrinogen to a straight line as for controls, indicating that 6-aminohexanoic acid abolishes the fibrinogen-induced inhibition. Aminocaproic Acid 18-39 fibrinogen beta chain Homo sapiens 195-205 2143650-5 1990 Addition of 0.1 mM-6-aminohexanoic acid shifted the non-linear curve obtained in the presence of fibrinogen to a straight line as for controls, indicating that 6-aminohexanoic acid abolishes the fibrinogen-induced inhibition. Aminocaproic Acid 19-39 fibrinogen beta chain Homo sapiens 97-107 2143650-5 1990 Addition of 0.1 mM-6-aminohexanoic acid shifted the non-linear curve obtained in the presence of fibrinogen to a straight line as for controls, indicating that 6-aminohexanoic acid abolishes the fibrinogen-induced inhibition. Aminocaproic Acid 19-39 fibrinogen beta chain Homo sapiens 195-205 2375765-0 1990 The thienopyridine PCR 4099 selectively inhibits ADP-induced platelet aggregation and fibrinogen binding without modifying the membrane glycoprotein IIb-IIIa complex in rat and in man. thienopyridine 4-18 fibrinogen beta chain Homo sapiens 86-96 2375765-2 1990 It has been shown that ticlopidine induces a functional defect in the binding of fibrinogen to its platelet membrane receptor. Ticlopidine 23-34 fibrinogen beta chain Homo sapiens 81-91 2375765-10 1990 Fibrinogen binding was dramatically inhibited in rat and in man when platelets were stimulated with ADP and low concentrations of thrombin. Adenosine Diphosphate 100-103 fibrinogen beta chain Homo sapiens 0-10 2372034-6 1990 Fibrinogen increased in the luteal phase, and all samples of fibrinogen correlated positively with progesterone concentration. Progesterone 99-111 fibrinogen beta chain Homo sapiens 61-71 2389831-4 1990 The results showed treatment with ticlopidine improved the neurologic outcome (Hachinski"s Score +36%, p less than 0.03) slightly but significantly (p less than 0.001) increased the average values of the whole blood (+19%) and red cell (+17%) filterability rates and decreased fibrinogen levels (-17%). Ticlopidine 34-45 fibrinogen beta chain Homo sapiens 277-287 2252691-5 1990 Serum fibrinogen decreased by 62% (HELP) and 11% (DSA). dsa 50-53 fibrinogen beta chain Homo sapiens 6-16 2390136-3 1990 Three months of treatment with lovastatin resulted in a marked decrease in red cell aggregation and plasma viscosity, parallel to a fall in cholesterol (the following pretreatment values were monitored after a standard lipid-lowering diet; RCA-S: 7.59 +/- 1 vs. 6.65 +/- 0.9, RCA-L: 9.34 +/- 1 vs. 8.15 +/- 1 arbitrary units; PV: 1.74 vs. 1.65 mPa/s; Chol: 309.8 +/- 41 vs. 217.1 +/- 30 mg/dl; all P less than 0.01); fibrinogen however, remained unchanged throughout the treatment period (346.4 +/- 73.3 vs. 330.5 +/- 70.2 mg/dl, n.s.). Lovastatin 31-41 fibrinogen beta chain Homo sapiens 417-427 2141549-7 1990 Platelet stimulation with thrombin or ADP in the presence of fibrinogen also did not alter the number of Fc gamma binding sites or the affinity of binding. Adenosine Diphosphate 38-41 fibrinogen beta chain Homo sapiens 61-71 2379562-7 1990 Isoelectric focusing and SDS electrophoresis of reduced fibrinogen showed normal charge and size of the subunit chains. Sodium Dodecyl Sulfate 25-28 fibrinogen beta chain Homo sapiens 56-66 2365816-9 1990 In addition to FPB release, SDS-PAGE analysis of the time course of urokinase-mediated fibrinogenolysis indicates progressive proteolysis of both the A alpha- and B beta-chains of fibrinogen that occurs after FPB release is completed. Sodium Dodecyl Sulfate 28-31 fibrinogen beta chain Homo sapiens 87-97 2121564-2 1990 Cyclandelate induced a reduction in euglobulin lysis time, an increase in tissue plasminogen activator concentration and a reduction in plasminogen activator inhibitor, alpha 2-antiplasmin and immunological fibrinogen concentrations, but no changes in antithrombin III and plasminogen concentrations were observed. Cyclandelate 0-12 fibrinogen beta chain Homo sapiens 207-217 2376702-6 1990 Preincubation of platelets with high concentrations of PIA1 antibody inhibited platelet aggregation with 10 mumol/L adenosine diphosphate and blocked 125I-labeled fibrinogen platelet binding. Iodine-125 150-154 fibrinogen beta chain Homo sapiens 163-173 2402747-3 1990 Moreover the amounts of contaminating proteins such as fibronectin, factor XIII or plasminogen were negligible and the purity of the isolated fibrinogen was higher than 95% as measured by polyacrylamide gel electrophoresis. polyacrylamide 188-202 fibrinogen beta chain Homo sapiens 142-152 2402747-6 1990 Further, abnormal fibrinogen molecules, provided their complementary binding site for GlyProArg is preserved, may also be quantitatively isolated independent of any solubility differences as compared to normal fibrinogen. glycyl-prolyl-arginine 86-95 fibrinogen beta chain Homo sapiens 18-28 2402748-5 1990 However, immunoreactivity was detected when fibrin (prepared from fibrinogen) was solubilized with 8 M urea. Urea 103-107 fibrinogen beta chain Homo sapiens 66-76 2351647-7 1990 The addition of an anti-GPIIIa monoclonal antibody (mAb G10), which inhibits 125I-fibrinogen binding and platelet aggregation, completely blocked mAb F11-induced [14C]serotonin secretion and aggregation but not the binding of 125I-mAb F11 to platelets. Carbon-14 163-166 fibrinogen beta chain Homo sapiens 82-92 2396020-1 1990 We evaluated the diagnosis of thrombus and the effect of antithrombic therapy by using 67Ga-DFO-DAS-Fibrinogen (67Ga-Fbg.) Deferoxamine 92-95 fibrinogen beta chain Homo sapiens 100-110 2114170-2 1990 Several ECM protein components were as effective as fibrinogen fragments at stimulating Pg activation. pg 88-90 fibrinogen beta chain Homo sapiens 52-62 2114170-4 1990 The most effective stimulators of activation were basement membrane type IV collagen and gelatin which resulted in a 21- and 55-fold increase, respectively, in the kcat/Km of Glu-Pg (relative to a 10-fold increase observed with fibrinogen fragments). Glutamic Acid 175-178 fibrinogen beta chain Homo sapiens 228-238 2383621-0 1990 Influence of surface charge on adsorption of fibrinogen and/or albumin on a rotating disc electrode of platinum and carbon. Platinum 103-111 fibrinogen beta chain Homo sapiens 45-55 2383621-0 1990 Influence of surface charge on adsorption of fibrinogen and/or albumin on a rotating disc electrode of platinum and carbon. Carbon 116-122 fibrinogen beta chain Homo sapiens 45-55 2383621-1 1990 The adsorption of fibrinogen on to platinum and carbon and of albumin on to carbon was investigated for various changes of the surface by recording the variations of the double-layer capacitance of the electrochemical interface during adsorption, as a function of time. Platinum 35-43 fibrinogen beta chain Homo sapiens 18-28 2377005-4 1990 In this study, interactions of blood proteins (i.e. albumin and fibrinogen) with polyurethane biomaterial surfaces were investigated in an in vitro bead column test circuit using a stimulus-response technique. Polyurethanes 81-93 fibrinogen beta chain Homo sapiens 64-74 2395216-1 1990 We reported a 34-year-old female patient with refractory idiopathic thrombocytopenic purpura (ITP) in whom a subacute subdural hematoma occurred without any preceding trauma during danazol administration which resulted in a marked decrease of plasma fibrinogen level. Danazol 181-188 fibrinogen beta chain Homo sapiens 250-260 2328260-3 1990 119:219; 1986), and have demonstrated the specific binding of 125I-labeled HA to human fibrinogen (J. Biol. Iodine-125 62-66 fibrinogen beta chain Homo sapiens 87-97 2318833-6 1990 The beta-Fg gene is induced by dexamethasone and Il6 in HepG2. Dexamethasone 31-44 fibrinogen beta chain Homo sapiens 4-11 2334691-2 1990 This peptide was isolated from cyanogen bromide degraded human fibrinogen and was investigated by 1H NMR (500 MHz) spectroscopy. Cyanogen Bromide 31-47 fibrinogen beta chain Homo sapiens 63-73 2334691-2 1990 This peptide was isolated from cyanogen bromide degraded human fibrinogen and was investigated by 1H NMR (500 MHz) spectroscopy. Hydrogen 98-100 fibrinogen beta chain Homo sapiens 63-73 2192581-2 1990 Microscopic polystyrene-divinylbenzene beads coated with a mixed monomolecular film of lecithin and fibrinogen aggregate in aqueous media following exposure to thrombin or enzymes of thrombin-like activity. Amberlite XAD-2 resin 12-38 fibrinogen beta chain Homo sapiens 100-110 2190565-6 1990 Sulodexide lowered plasma viscosity and plasma fibrinogen in all patients. glucuronyl glucosamine glycan sulfate 0-10 fibrinogen beta chain Homo sapiens 47-57 2190565-10 1990 The results indicate that Sulodexide administration may be useful in long-term treatment of patients with peripheral vascular disease and a concomitant increase in plasma triglycerides and/or fibrinogen and/or viscosity. glucuronyl glucosamine glycan sulfate 26-36 fibrinogen beta chain Homo sapiens 192-202 2346725-11 1990 It also had a high binding affinity and was capable of inhibiting the binding of radiolabelled fibrinogen to the activated platelets at physiological calcium concentrations. Calcium 150-157 fibrinogen beta chain Homo sapiens 95-105 2347872-0 1990 Fibrinogen-aluminum interaction: changes with oxide layer thickness onto metal surface. Aluminum 11-19 fibrinogen beta chain Homo sapiens 0-10 2347872-0 1990 Fibrinogen-aluminum interaction: changes with oxide layer thickness onto metal surface. Oxides 46-51 fibrinogen beta chain Homo sapiens 0-10 2182759-8 1990 PAI-1 and fibrinogen levels correlated negatively with the rate of glucose disposal. Glucose 67-74 fibrinogen beta chain Homo sapiens 10-20 2373893-0 1990 [Effectiveness of fibrinogen to avoid serous fluid leakage through polytetrafluoroethylene (PTFE) tubular graft]. Polytetrafluoroethylene 67-90 fibrinogen beta chain Homo sapiens 18-28 2373893-0 1990 [Effectiveness of fibrinogen to avoid serous fluid leakage through polytetrafluoroethylene (PTFE) tubular graft]. Polytetrafluoroethylene 92-96 fibrinogen beta chain Homo sapiens 18-28 2358716-3 1990 1) After chemotherapy, the levels of fibrinogen were increased, ATIII was decreased significantly in cases in the NC.PD group compared with the PR.CR group (p less than 0.05). Palladium 117-119 fibrinogen beta chain Homo sapiens 37-47 2107563-10 1990 At 24 hours, fibrinogen levels were significantly lower in the rt-PA group than in the UK group (P = .01). rt-pa 63-68 fibrinogen beta chain Homo sapiens 13-23 2129390-5 1990 In the presence of fibrinogen, activation rates for both Lys and Glu-plasminogen were increased. Lysine 57-60 fibrinogen beta chain Homo sapiens 19-29 2185764-4 1990 Plasma fibrinogen, as the major contributing factor to plasma viscosity and red-blood-cell aggregation can limit oxygen supply and blood flow in microcirculation even in the absence of apparent coronary artery disease. Oxygen 113-119 fibrinogen beta chain Homo sapiens 7-17 2140287-0 1990 Binding of staphylococcal cell surface polysaccharide to human fibrinogen. Polysaccharides 39-53 fibrinogen beta chain Homo sapiens 63-73 2140287-1 1990 The interaction between the binding site of a polysaccharide (called compact colony forming active substance (CCFAS)), obtained from the cell surface of a strain of Staphylococcus, and human fibrinogen (HF) was investigated. Polysaccharides 46-60 fibrinogen beta chain Homo sapiens 191-201 2140287-6 1990 Binding of CCFAS (7 micrograms) with fibrinogen could be inhibited by 1.2 micrograms of B beta chain and 1.5 micrograms gamma chain at alkaline pH or 6.2 micrograms of the A alpha chain at pH 5.0. compact-colony-forming active substance 11-16 fibrinogen beta chain Homo sapiens 37-47 2407587-1 1990 ADP is known to induce platelet shape change, aggregation, and exposure of fibrinogen binding sites as well as inhibit stimulated adenylate cyclase. Adenosine Diphosphate 0-3 fibrinogen beta chain Homo sapiens 75-85 2407587-4 1990 Concomitant with incorporation of FSBA, ADP-induced shape change, aggregation, and fibrinogen binding is inhibited. Adenosine Diphosphate 40-43 fibrinogen beta chain Homo sapiens 83-93 2237813-1 1990 Ultrastructural studies of ADP-stimulated gel-filtered human platelets incubated with different concentrations of fibrinogen reveal unusual extracellular structures composed at least partly of the aggregated fibrinogen. Adenosine Diphosphate 27-30 fibrinogen beta chain Homo sapiens 114-124 2237813-1 1990 Ultrastructural studies of ADP-stimulated gel-filtered human platelets incubated with different concentrations of fibrinogen reveal unusual extracellular structures composed at least partly of the aggregated fibrinogen. Adenosine Diphosphate 27-30 fibrinogen beta chain Homo sapiens 208-218 2381963-1 1990 Human, rat and bovine fibrinogen were radioiodinated using a modified chloramine-T method under mild labelling conditions and with a satisfactory labelling efficiency. chloramine-T 70-82 fibrinogen beta chain Homo sapiens 22-32 2381963-3 1990 SDS-PAGE mobility demonstrated that the integrity of the fibrinogen molecule was not affected by the labelling procedure. Sodium Dodecyl Sulfate 0-3 fibrinogen beta chain Homo sapiens 57-67 2154836-3 1990 In the three patients who developed disseminated intravascular coagulation (DIC) after TAE, a reduction of both the platelet count and fibrinogen level occurred significantly earlier and in a more severe form than in the other patients without DIC; this reduction preceded the onset of the characteristic symptoms of DIC. tae 87-90 fibrinogen beta chain Homo sapiens 135-145 2339369-6 1990 Forty-eight hours after SK, a new fibrinogen hyperfunction, related to an increase in fibrinogen level and especially HMW synthesized fibrinogen (82 +/- 1 or 81 +/- 1%, 800,000 and 1.5 mill U SK, respectively) was observed, which was neutralized by heparin therapy (1,660 U/h with continuous infusion). Heparin 249-256 fibrinogen beta chain Homo sapiens 34-44 2154836-4 1990 Data suggested that close monitoring of platelet count and fibrinogen level is important for early detection of DIC following TAE. tae 126-129 fibrinogen beta chain Homo sapiens 59-69 2348567-0 1990 [Assay of glycated fibrinogen in plasma as an indicator of blood glucose control]. Blood Glucose 59-72 fibrinogen beta chain Homo sapiens 19-29 2348567-2 1990 This method is based on the measurement of 1-deoxy-1-morpholino-D-fructose (DMF) in the fibrinogen (Fbg) solution separated from plasma and redissolved. 1-Deoxy-1-morpholino-D-fructose 43-74 fibrinogen beta chain Homo sapiens 88-98 2403558-14 1990 Affinity chromatography of surface-labeled cell extracts on fibrinogen-Sepharose revealed a 94 +/- 2-kDa membrane protein that bound specifically to fibrinogen-Sepharose only on cells that expressed the MFR. Sepharose 71-80 fibrinogen beta chain Homo sapiens 60-70 2348567-2 1990 This method is based on the measurement of 1-deoxy-1-morpholino-D-fructose (DMF) in the fibrinogen (Fbg) solution separated from plasma and redissolved. 1-Deoxy-1-morpholino-D-fructose 43-74 fibrinogen beta chain Homo sapiens 100-103 2348567-2 1990 This method is based on the measurement of 1-deoxy-1-morpholino-D-fructose (DMF) in the fibrinogen (Fbg) solution separated from plasma and redissolved. Dimethylformamide 76-79 fibrinogen beta chain Homo sapiens 88-98 2348567-2 1990 This method is based on the measurement of 1-deoxy-1-morpholino-D-fructose (DMF) in the fibrinogen (Fbg) solution separated from plasma and redissolved. Dimethylformamide 76-79 fibrinogen beta chain Homo sapiens 100-103 2348567-7 1990 G-Fbg measured by this method correlated significantly with the amount of furosine that was a specific product by hydrolysis of glycated lysine residue. furosine 74-82 fibrinogen beta chain Homo sapiens 2-5 2348567-7 1990 G-Fbg measured by this method correlated significantly with the amount of furosine that was a specific product by hydrolysis of glycated lysine residue. Lysine 137-143 fibrinogen beta chain Homo sapiens 2-5 2348567-9 1990 The average of G-Fbg values in 78 diabetic patients (23.8 +/- 10.7 mumol DMF/g Fbg) was significantly higher than in 26 normal subjects (9.2 +/- 3.8 mumol DMF/g Fbg). Dimethylformamide 73-76 fibrinogen beta chain Homo sapiens 17-20 2348567-10 1990 The G-Fbg value correlated with blood glucose at the same time or one day earlier than 1-2 weeks or 1 month earlier. Glucose 38-45 fibrinogen beta chain Homo sapiens 6-9 2348567-11 1990 These results suggest that assay of G-Fbg by this method may be useful in monitoring short-term control of blood glucose in diabetic patients. Blood Glucose 107-120 fibrinogen beta chain Homo sapiens 38-41 2326770-11 1990 This may suggest that fibrinogen in some way interfered with the stimulating effect of fibrin on the t-PA catalyzed activation of plasminogen, the principle upon which the COA-SET FM test is based. t-pa 101-105 fibrinogen beta chain Homo sapiens 22-32 2334711-0 1990 Disulfide bond reduction in fibrinogen: calcium protection and effect on clottability. Disulfides 0-9 fibrinogen beta chain Homo sapiens 28-38 2334711-0 1990 Disulfide bond reduction in fibrinogen: calcium protection and effect on clottability. Calcium 40-47 fibrinogen beta chain Homo sapiens 28-38 2334711-1 1990 Fibrinogen contains 29 disulfide bonds. Disulfides 23-32 fibrinogen beta chain Homo sapiens 0-10 2334711-6 1990 N-Terminal analysis of thrombin-treated samples showed that thrombin cleavage occurred at the normal A alpha 16-A alpha 17 site in fibrinogen that was partially reduced in the presence of calcium. Calcium 188-195 fibrinogen beta chain Homo sapiens 131-141 2295300-3 1990 Fibrinogen elimination reduced plasma viscosity by 13-14% and clearly raised the transcutaneously measured partial pressure of oxygen by 33-50%. Oxygen 127-133 fibrinogen beta chain Homo sapiens 0-10 2403558-14 1990 Affinity chromatography of surface-labeled cell extracts on fibrinogen-Sepharose revealed a 94 +/- 2-kDa membrane protein that bound specifically to fibrinogen-Sepharose only on cells that expressed the MFR. Sepharose 71-80 fibrinogen beta chain Homo sapiens 149-159 2403558-14 1990 Affinity chromatography of surface-labeled cell extracts on fibrinogen-Sepharose revealed a 94 +/- 2-kDa membrane protein that bound specifically to fibrinogen-Sepharose only on cells that expressed the MFR. Sepharose 160-169 fibrinogen beta chain Homo sapiens 60-70 2403558-14 1990 Affinity chromatography of surface-labeled cell extracts on fibrinogen-Sepharose revealed a 94 +/- 2-kDa membrane protein that bound specifically to fibrinogen-Sepharose only on cells that expressed the MFR. Sepharose 160-169 fibrinogen beta chain Homo sapiens 149-159 2403558-16 1990 This was confirmed by cross-linking fibrinogen to surface-labeled Raji cells using the cleavable cross-linkers, ethyleneglycobis(succinimidyl succinate) and dithiobis(succinimidyl propionate). ethyleneglycobis(succinimidyl succinate 112-151 fibrinogen beta chain Homo sapiens 36-46 2403558-16 1990 This was confirmed by cross-linking fibrinogen to surface-labeled Raji cells using the cleavable cross-linkers, ethyleneglycobis(succinimidyl succinate) and dithiobis(succinimidyl propionate). dithiobis(succinimidylpropionate) 157-190 fibrinogen beta chain Homo sapiens 36-46 1966352-6 1990 Zn++ (50 microM) was required for binding of 125I-fibrinogen to neutrophils and the addition of Ca++ (2 mM) increased the binding 2-fold. Zinc 0-4 fibrinogen beta chain Homo sapiens 50-60 1966352-12 1990 These observations were consistent with a further finding that fibrinogen is a noncompetitive inhibitor of 125I-HK binding to neutrophils. 125i-hk 107-114 fibrinogen beta chain Homo sapiens 63-73 2076620-6 1990 Furthermore, plasma fibrinogen levels increased by a mean of 17.6%, a potentially adverse effect of gemfibrozil that has not been previously reported. Gemfibrozil 100-111 fibrinogen beta chain Homo sapiens 20-30 1982820-11 1990 EF BTG showed direct significant correlation (p less than 0.05) with Creatinine-MTC (r: 0.81) and EF Fibrinogen (0.68) and in the limit of significance with EF T. prot (0.57) and EF Mitogenicity (0.62). beta-2'-deoxythioguanosine 3-6 fibrinogen beta chain Homo sapiens 101-111 2132164-3 1990 Spearman"s correlations demonstrated statistically significant positive relationships in type II diabetic patients between fibrinogen levels and fasting glucose levels, serum cholesterol, glycosylated hemoglobin and urinary albumin excretion rate. Glucose 153-160 fibrinogen beta chain Homo sapiens 123-133 2132164-3 1990 Spearman"s correlations demonstrated statistically significant positive relationships in type II diabetic patients between fibrinogen levels and fasting glucose levels, serum cholesterol, glycosylated hemoglobin and urinary albumin excretion rate. Cholesterol 175-186 fibrinogen beta chain Homo sapiens 123-133 1974871-3 1990 At higher doses (approximately 1 mM), a weak inhibition of ADP- and collagen-induced aggregation was observed; at these concentrations, buflomedil inhibits granular secretion and the interaction of fibrinogen with its receptor on platelet. buflomedil 136-146 fibrinogen beta chain Homo sapiens 198-208 2086417-8 1990 As the plasma viscosity may participate in the deterioration of microcirculation in patients with giant cell arteritis, lowering the fibrinogen may possibly prevent a further decrease in visual acuity during the first few days of steroid treatment. Steroids 230-237 fibrinogen beta chain Homo sapiens 133-143 2213080-3 1990 In both sexes, multivariate analysis showed that fibrinogen was positively associated with age, smoking, total cholesterol and body mass index and negatively associated with alcohol consumption. Cholesterol 111-122 fibrinogen beta chain Homo sapiens 49-59 2149071-0 1990 Plasma gas discharge deposited fluorocarbon polymers exhibit reduced elutability of adsorbed albumin and fibrinogen. Fluorocarbons 31-43 fibrinogen beta chain Homo sapiens 105-115 2149071-0 1990 Plasma gas discharge deposited fluorocarbon polymers exhibit reduced elutability of adsorbed albumin and fibrinogen. Polymers 44-52 fibrinogen beta chain Homo sapiens 105-115 2149071-3 1990 The adsorption of fibrinogen and albumin to these fluorocarbon-coated surfaces was comparable to the adsorption of the proteins to polytetrafluoroethylene (PTFE) and PET. Fluorocarbons 50-62 fibrinogen beta chain Homo sapiens 18-28 2149071-4 1990 However, the elutability of fibrinogen and albumin from the RFGD fluorocarbon surfaces with sodium dodecyl sulfate was much lower than that from PTFE or PET. Fluorocarbons 65-77 fibrinogen beta chain Homo sapiens 28-38 2149071-4 1990 However, the elutability of fibrinogen and albumin from the RFGD fluorocarbon surfaces with sodium dodecyl sulfate was much lower than that from PTFE or PET. Sodium Dodecyl Sulfate 92-114 fibrinogen beta chain Homo sapiens 28-38 2213080-3 1990 In both sexes, multivariate analysis showed that fibrinogen was positively associated with age, smoking, total cholesterol and body mass index and negatively associated with alcohol consumption. Alcohols 174-181 fibrinogen beta chain Homo sapiens 49-59 2345158-6 1990 Pretreatment of the column with heparin reduced the loss of fibrinogen to less than 10%. Heparin 32-39 fibrinogen beta chain Homo sapiens 60-70 2319934-0 1990 Proton relaxation enhancement of albumin, immunoglobulin G, and fibrinogen labeled with Gd-DTPA. Gadolinium DTPA 88-95 fibrinogen beta chain Homo sapiens 64-74 2319934-1 1990 Bovine serum albumin, immunoglobulin G, and fibrinogen were labeled with Gd-DTPA using a bifunctional chelating agent DTPA anhydride. Gadolinium DTPA 73-80 fibrinogen beta chain Homo sapiens 44-54 2202919-1 1990 The influence of uremic serum on 125I-fibrinogen binding by normal blood platelets after induction with adenosine diphosphate was evaluated. Adenosine Diphosphate 104-125 fibrinogen beta chain Homo sapiens 38-48 2381284-0 1990 [Thrombin-fibrinogen interaction: release of fibrinopeptides and the effects of ATP]. Adenosine Triphosphate 80-83 fibrinogen beta chain Homo sapiens 10-20 2321399-8 1990 An influence of fibrinogen on fructosamine is also conceivable. Fructosamine 30-42 fibrinogen beta chain Homo sapiens 16-26 3964817-10 1985 Thymidine uptake by two continuous lymphoblastoid cell lines also is inhibited by the peptides, indicating a direct effect of the fibrinogen-derived peptides on lymphocytes. Thymidine 0-9 fibrinogen beta chain Homo sapiens 130-140 3096886-8 1986 The number of fibrinogen-binding sites per cell varies from 500 to 1,500 in different batches of bacteria, and the dissociation constant for the complex is on the order of 10(-8) M. B. gingivalis possesses cell-associated fibrinogenolytic activity that is activated by dithiothreitol and blocked by thiol protease inhibitors. Dithiothreitol 269-283 fibrinogen beta chain Homo sapiens 14-24 33973891-9 2021 Immediately following completion of FCH administration, a rapid increase in plasma fibrinogen levels to near baseline (median change from baseline -0.10 g/l) was seen in the FCH group but not in the placebo group (median change from baseline -1.29 g/l). fluorocholine 174-177 fibrinogen beta chain Homo sapiens 83-93 33774074-17 2021 Another small trial showed that supplementation with cholecalciferol, 60,000 IU/d, decreased fibrinogen levels, but did not have an effect on D-dimer, procalcitonin and CRP levels, compared to placebo. Cholecalciferol 53-68 fibrinogen beta chain Homo sapiens 93-103 33973891-12 2021 Treatment with high doses of FCH with a rapid infusion time resulted in immediate recovery to baseline levels of plasma fibrinogen and viscoelastic testing parameters. fluorocholine 29-32 fibrinogen beta chain Homo sapiens 120-130 33807403-8 2021 In addition, pterostilbene affected integrin alphaIIbbeta3-mediated outside-in signaling, such as integrin beta3, Src, and FAK phosphorylation, and reduced the number of adherent platelets and the single platelet spreading area on immobilized fibrinogen as well as thrombin-stimulated fibrin clot retraction. pterostilbene 13-26 fibrinogen beta chain Homo sapiens 243-253 33767136-8 2021 In our proof-of-concept experiment, we demonstrate the viability of the approach by detecting different concentrations of fibrinogen in phosphate-buffered saline solutions with a sensor-length (L-)-related sensitivity of S/L = 0.16 rad nM-1 mm-1. Phosphate-Buffered Saline 136-161 fibrinogen beta chain Homo sapiens 122-132 33775664-0 2021 The Relationship of Circulating Homocysteine With Fibrinogen, Blood Pressure and Other Cardiovascular Measures in African Adolescents. Homocysteine 32-44 fibrinogen beta chain Homo sapiens 50-60 33815366-10 2021 Conversely, the serine protease inhibitor 4-(2-aminoethyl)benzenesulfonyl fluoride hydrochloride (AEBSF) inhibited the direct fibrinogen cleaving actions of C. mictlantecuhtli venom, thereby revealing that the pseudo-procoagulant action is driven by kallikrein-type serine proteases. Serine 16-22 fibrinogen beta chain Homo sapiens 126-136 33815366-10 2021 Conversely, the serine protease inhibitor 4-(2-aminoethyl)benzenesulfonyl fluoride hydrochloride (AEBSF) inhibited the direct fibrinogen cleaving actions of C. mictlantecuhtli venom, thereby revealing that the pseudo-procoagulant action is driven by kallikrein-type serine proteases. 4-(2-aminoethyl)benzenesulfonylfluoride 42-96 fibrinogen beta chain Homo sapiens 126-136 33815366-10 2021 Conversely, the serine protease inhibitor 4-(2-aminoethyl)benzenesulfonyl fluoride hydrochloride (AEBSF) inhibited the direct fibrinogen cleaving actions of C. mictlantecuhtli venom, thereby revealing that the pseudo-procoagulant action is driven by kallikrein-type serine proteases. 4-(2-aminoethyl)benzenesulfonylfluoride 98-103 fibrinogen beta chain Homo sapiens 126-136 34813642-3 2021 Herein, we focus on exploring the role of ligand adsorption modes (physiosorbed citrates or chemisorbed GSH) in the regulation of conformational rearrangement of three blood proteins (serum albumin, globulin, and fibrinogen) on the surface of gold nanoparticles. Glutathione 104-107 fibrinogen beta chain Homo sapiens 213-223 33973891-9 2021 Immediately following completion of FCH administration, a rapid increase in plasma fibrinogen levels to near baseline (median change from baseline -0.10 g/l) was seen in the FCH group but not in the placebo group (median change from baseline -1.29 g/l). fluorocholine 36-39 fibrinogen beta chain Homo sapiens 83-93 34510718-9 2022 Resistance against fibrinogen absorption on zwitterionic modified PES membrane could be linked with the creation of electrostatically induced neutral zwitterionic PVP-phosphobetaine hydration layer with hydrophilic character. polyether sulfone 66-69 fibrinogen beta chain Homo sapiens 19-29 34510718-9 2022 Resistance against fibrinogen absorption on zwitterionic modified PES membrane could be linked with the creation of electrostatically induced neutral zwitterionic PVP-phosphobetaine hydration layer with hydrophilic character. Povidone 163-166 fibrinogen beta chain Homo sapiens 19-29 34510718-9 2022 Resistance against fibrinogen absorption on zwitterionic modified PES membrane could be linked with the creation of electrostatically induced neutral zwitterionic PVP-phosphobetaine hydration layer with hydrophilic character. phosphobetaine 167-181 fibrinogen beta chain Homo sapiens 19-29 34510718-12 2022 The zeta potential and surface roughness of coated membranes also played significant role in the fibrinogen adsorption on PES membranes during ultrafiltration. polyether sulfone 122-125 fibrinogen beta chain Homo sapiens 97-107 34674369-4 2022 Here we review recent evidence for production and function of multiple partially disulfide-bonded forms of plasma fibrinogen and platelet alphaIIbbeta3 integrin. Disulfides 81-90 fibrinogen beta chain Homo sapiens 114-124 34964643-2 2022 The effect of FIB on the therapeutic potency of four FDA-approved Alzheimer"s disease drugs, namely, tacrine (TAC), donepezil (DON), eserine (ESE), and huperzine (HUP), was investigated through a combination of different in vitro and in silico experiments. Tacrine 101-108 fibrinogen beta chain Homo sapiens 14-17 34964643-2 2022 The effect of FIB on the therapeutic potency of four FDA-approved Alzheimer"s disease drugs, namely, tacrine (TAC), donepezil (DON), eserine (ESE), and huperzine (HUP), was investigated through a combination of different in vitro and in silico experiments. Tacrine 110-113 fibrinogen beta chain Homo sapiens 14-17 34964643-2 2022 The effect of FIB on the therapeutic potency of four FDA-approved Alzheimer"s disease drugs, namely, tacrine (TAC), donepezil (DON), eserine (ESE), and huperzine (HUP), was investigated through a combination of different in vitro and in silico experiments. Donepezil 116-125 fibrinogen beta chain Homo sapiens 14-17 34964643-2 2022 The effect of FIB on the therapeutic potency of four FDA-approved Alzheimer"s disease drugs, namely, tacrine (TAC), donepezil (DON), eserine (ESE), and huperzine (HUP), was investigated through a combination of different in vitro and in silico experiments. Donepezil 127-130 fibrinogen beta chain Homo sapiens 14-17 34964643-2 2022 The effect of FIB on the therapeutic potency of four FDA-approved Alzheimer"s disease drugs, namely, tacrine (TAC), donepezil (DON), eserine (ESE), and huperzine (HUP), was investigated through a combination of different in vitro and in silico experiments. Physostigmine 133-140 fibrinogen beta chain Homo sapiens 14-17 34964643-2 2022 The effect of FIB on the therapeutic potency of four FDA-approved Alzheimer"s disease drugs, namely, tacrine (TAC), donepezil (DON), eserine (ESE), and huperzine (HUP), was investigated through a combination of different in vitro and in silico experiments. Physostigmine 142-145 fibrinogen beta chain Homo sapiens 14-17 34964643-2 2022 The effect of FIB on the therapeutic potency of four FDA-approved Alzheimer"s disease drugs, namely, tacrine (TAC), donepezil (DON), eserine (ESE), and huperzine (HUP), was investigated through a combination of different in vitro and in silico experiments. huperzine A 152-161 fibrinogen beta chain Homo sapiens 14-17 34964643-2 2022 The effect of FIB on the therapeutic potency of four FDA-approved Alzheimer"s disease drugs, namely, tacrine (TAC), donepezil (DON), eserine (ESE), and huperzine (HUP), was investigated through a combination of different in vitro and in silico experiments. huperzine A 163-166 fibrinogen beta chain Homo sapiens 14-17 34875515-5 2022 Human primary hepatocyte organoids and HepaRG spheroids showed more mature hepatocyte phenotype after adding fibronectin and fibrinogen to the culture system. heparg 39-45 fibrinogen beta chain Homo sapiens 125-135 34648684-0 2022 Polysaccharide-Protein Multilayers Based on Chitosan-Fibrinogen Assemblies for Cardiac Cell Engineering. Polysaccharides 0-14 fibrinogen beta chain Homo sapiens 53-63 34970417-2 2021 Methylglyoxal (MG) induces glycation of fibrinogen, resulting in structural alterations that lead to autoimmune response via the generation of neoepitopes on protein molecules. Pyruvaldehyde 0-13 fibrinogen beta chain Homo sapiens 40-50 34970417-2 2021 Methylglyoxal (MG) induces glycation of fibrinogen, resulting in structural alterations that lead to autoimmune response via the generation of neoepitopes on protein molecules. Pyruvaldehyde 15-17 fibrinogen beta chain Homo sapiens 40-50 33589702-6 2021 The geometric means of fibrinogen (g/L) across increasing quintiles of nutrient intake were 3.22, 3.22, 3.22, 3.16, and 3.19 (p-trend = 0.030) for vitamin E; 3.23, 3.22, 3.20, 3.19, and 3.19 (p-trend = 0.047) for magnesium; and 3.24, 3.22, 3.19, 3.21, and 3.19 (p-trend = 0.050) for iron. Vitamin E 147-156 fibrinogen beta chain Homo sapiens 23-33 33589702-8 2021 Although dietary intakes of vitamin E, magnesium and iron were inversely associated with fibrinogen levels, clinical implications of these findings are uncertain since these results were of very small magnitude and mostly explained by intake levels of other nutrients. Vitamin E 28-37 fibrinogen beta chain Homo sapiens 89-99 33589702-8 2021 Although dietary intakes of vitamin E, magnesium and iron were inversely associated with fibrinogen levels, clinical implications of these findings are uncertain since these results were of very small magnitude and mostly explained by intake levels of other nutrients. Iron 53-57 fibrinogen beta chain Homo sapiens 89-99 33763243-11 2020 Conclusions: In a cohort of elderly patients with UBC treated with RC, fibrinogen and mGPS appeared to be the most relevant prognostic measurements and increased the accuracy of clinicopathological preoperative models to predict major postoperative complications, disease recurrence and mortality. 1-(2-amino-2-carboxyethyl)-3-(2-carboxybenzyl)pyrimidine-2,4-dione 50-53 fibrinogen beta chain Homo sapiens 71-81 26600057-7 2015 Testosterone-metformin combination therapy decreased also total and LDL cholesterol, uric acid, hsCRP, homocysteine and fibrinogen, as well as increased plasma testosterone. Testosterone 0-12 fibrinogen beta chain Homo sapiens 120-130 26600057-7 2015 Testosterone-metformin combination therapy decreased also total and LDL cholesterol, uric acid, hsCRP, homocysteine and fibrinogen, as well as increased plasma testosterone. Metformin 13-22 fibrinogen beta chain Homo sapiens 120-130 25155500-8 2015 Multivariate logistic regression revealed that, after adjusting for potential confounders (anemia, age > 40 years, gender, and fibrinogen >382 mg/dL, total cholesterol >240 mg/dL, and BMI > 28.7 kg/m(2)), RDW >14% was the only parameter that independently increased the risk of CS. Cholesterol 162-173 fibrinogen beta chain Homo sapiens 130-140 22549098-7 2012 8-iso-PGF2alpha correlated positively with ADMA (r = 0.82), SDMA (r = 0.72), CRP (r = 0.76), fibrinogen (r = 0.57) (all, P <0.0001) and DAS28 (r = 0.44, P = 0.003). 8-epi-prostaglandin F2alpha 0-15 fibrinogen beta chain Homo sapiens 93-103 34821070-3 2022 Since the diameter of D-terminal of a fibrinogen molecule is 9 nm, four different pore sizes (2, 8, 14, and 20 nm) are rationally selected to design mesoporous silica to control the fibrinogen adsorption and modulate the subsequent fibrin formation process. mesoporous silica 149-166 fibrinogen beta chain Homo sapiens 38-48 34821070-3 2022 Since the diameter of D-terminal of a fibrinogen molecule is 9 nm, four different pore sizes (2, 8, 14, and 20 nm) are rationally selected to design mesoporous silica to control the fibrinogen adsorption and modulate the subsequent fibrin formation process. mesoporous silica 149-166 fibrinogen beta chain Homo sapiens 182-192 34945271-10 2021 Ks correlated with CLT (r = -0.28), FVIII (r = -0.30), FIX (r = -0.38), fibrinogen (r = -0.41), ALT (r = -0.25), AST (r = -0.26), GGTP (r = -0.27) and vWF antigen (r = -0.30), (all p < 0.05). Potassium 0-2 fibrinogen beta chain Homo sapiens 72-82 34943112-3 2021 The analyses of structural modifications of human fibrinogen under oxidative stress conditions (C-ELISA, SDS-PAGE and Western blot) revealed that the extracts (at a concentration of 1-5 microg/mL) considerably reduced the nitration of tyrosine residues and formation of high-molecular-weight aggregates. Sodium Dodecyl Sulfate 105-108 fibrinogen beta chain Homo sapiens 50-60 34943112-3 2021 The analyses of structural modifications of human fibrinogen under oxidative stress conditions (C-ELISA, SDS-PAGE and Western blot) revealed that the extracts (at a concentration of 1-5 microg/mL) considerably reduced the nitration of tyrosine residues and formation of high-molecular-weight aggregates. Tyrosine 235-243 fibrinogen beta chain Homo sapiens 50-60 34920728-6 2021 The stable isotope L-(ring-2H5)phenylalanine was used to measure absolute synthesis rates (ASR) of albumin and fibrinogen. l-(ring-2h5)phenylalanine 19-44 fibrinogen beta chain Homo sapiens 111-121 34886719-7 2021 When both fibrinogen and MR-proADM were included in the survival model, a doubling in fibrinogen and MR-proADM levels gave a 2.2 (95% CI 1.3-3.7) and 2.1 (95% CI 1.5-3.0) fold increased risk of dying, respectively. proadm 28-34 fibrinogen beta chain Homo sapiens 86-96 34555851-0 2021 Differential sialic acid content in adult and neonatal fibrinogen mediates differences in clot polymerization dynamics. N-Acetylneuraminic Acid 13-24 fibrinogen beta chain Homo sapiens 55-65 34555851-1 2021 Neonates possess a molecular variant of fibrinogen, known as fetal fibrinogen, characterized by increased sialic acid, a greater negative charge, and decreased activity compared to adults. N-Acetylneuraminic Acid 106-117 fibrinogen beta chain Homo sapiens 40-50 34555851-1 2021 Neonates possess a molecular variant of fibrinogen, known as fetal fibrinogen, characterized by increased sialic acid, a greater negative charge, and decreased activity compared to adults. N-Acetylneuraminic Acid 106-117 fibrinogen beta chain Homo sapiens 67-77 34555851-5 2021 We hypothesized that the increased sialic acid content of neonatal fibrinogen promotes fibrin B:b knob hole interactions and consequently influences the structure and function of the neonatal fibrin matrix. N-Acetylneuraminic Acid 35-46 fibrinogen beta chain Homo sapiens 67-77 34555851-8 2021 We determined that sialic acid content of neonatal fibrinogen is a key determinant of resulting clot properties. N-Acetylneuraminic Acid 19-30 fibrinogen beta chain Homo sapiens 51-61 34902868-5 2021 Upon conversion of fibrinogen into fibrin, the alphaC-domains switch from intra- to intermolecular interactions to form ordered alphaC polymers. Polymers 135-143 fibrinogen beta chain Homo sapiens 19-29 34886719-7 2021 When both fibrinogen and MR-proADM were included in the survival model, a doubling in fibrinogen and MR-proADM levels gave a 2.2 (95% CI 1.3-3.7) and 2.1 (95% CI 1.5-3.0) fold increased risk of dying, respectively. proadm 104-110 fibrinogen beta chain Homo sapiens 10-20 34185392-5 2021 DNA sequencing of the proband revealed a heterozygous point mutation in exon 8 of the FGB gene causing Trp Stop substitution and a polymorphic site (p.Leu92Phe). Tryptophan 103-106 fibrinogen beta chain Homo sapiens 86-89 34185392-7 2021 SDS-PAGE showed that the fibrinogen level of the proband was markedly lower than that of healthy controls. Sodium Dodecyl Sulfate 0-3 fibrinogen beta chain Homo sapiens 25-35 34637170-6 2021 Multivariate analyses revealed that increased fibrinogen, increased ferritin and decreased lymphocyte count were independent risk factors for large difference between SpO2 and SaO2 . spo2 167-171 fibrinogen beta chain Homo sapiens 46-56 34637170-6 2021 Multivariate analyses revealed that increased fibrinogen, increased ferritin and decreased lymphocyte count were independent risk factors for large difference between SpO2 and SaO2 . sao2 176-180 fibrinogen beta chain Homo sapiens 46-56 34091123-14 2021 010); AT III% was negatively predicted by the C-P classification (P = 0.000); copper levels, adjusted for C-P classification, were predicted by AT III% (P = 0.020) and fibrinogen concentrations, but not by PT% (P = 0.09). Copper 78-84 fibrinogen beta chain Homo sapiens 168-178 34091123-0 2021 Copper concentrations are prevalently associated with antithrombin III, but also with prothrombin time and fibrinogen in patients with liver cirrhosis: A cross-sectional retrospective study. Copper 0-6 fibrinogen beta chain Homo sapiens 107-117 34644005-4 2021 The zwitterionic pMPCDA coating exhibited excellent antifouling activity and resisted bacterial adhesion, fibrinogen adsorption, and platelet adhesion/activation. pmpcda 17-23 fibrinogen beta chain Homo sapiens 106-116 34840729-3 2021 Methods: A single-center retrospective study was conducted to identify the relationship between preoperative D-dimer and fibrinogen levels on SAAAD postoperative early prognosis. saaad 142-147 fibrinogen beta chain Homo sapiens 121-131 34681389-0 2021 Interaction of Carbon Dots from Grilled Spanish Mackerel with Human Serum Albumin, gamma-Globulin and Fibrinogen. Carbon 15-21 fibrinogen beta chain Homo sapiens 83-112 34783023-7 2022 Carriers of FGB rs1800790 A allele and F13 rs5985 T allele had lower Ks , prolonged CLT, and higher ETP compared with major homozygotes (all p<0.05). Potassium 69-71 fibrinogen beta chain Homo sapiens 12-15 34670087-0 2021 Influence of Divalent Metal Ions on the Precipitation of the Plasma Protein Fibrinogen. Metals 22-27 fibrinogen beta chain Homo sapiens 76-86 34670087-2 2021 Previously, we reported the self-assembly of fibrinogen nanofibers in the presence of monovalent salts and have now studied how divalent salts influence fibrinogen precipitation. divalent salts 128-142 fibrinogen beta chain Homo sapiens 153-163 34670087-3 2021 Although the secondary fibrinogen structure was significantly altered with divalent metal ions, morphological analysis revealed exclusively smooth fibrinogen precipitates. Metals 84-89 fibrinogen beta chain Homo sapiens 23-33 34670087-5 2021 Analysis of the chemical composition revealed that divalent salts were removed from smooth fibrinogen films upon rinsing while monovalent Na+ species were still present in fibrinogen fibers. divalent salts 51-65 fibrinogen beta chain Homo sapiens 91-101 34668502-0 2021 Study of the interaction of folic acid-modified gold nanorods and fibrinogen through microfluidics: implications for protein adsorption, incorporation and viability of cancer cells. Folic Acid 28-38 fibrinogen beta chain Homo sapiens 66-76 34731444-6 2022 By LOWESS analysis, a linear relationship could be assumed for CRP and fibrinogen, while a threshold effect was apparent in the relationship between TT and procalcitonin, LDH and ferritin. Testosterone 149-151 fibrinogen beta chain Homo sapiens 71-81 34684880-0 2021 Deposition of Polymer Particles with Fibrinogen Corona at Abiotic Surfaces under Flow Conditions. Polymers 14-21 fibrinogen beta chain Homo sapiens 37-47 34675546-0 2021 Early Prediction of Objective Response of Fibrinogen in a Real-World Cohort of Hepatocellular Carcinoma Cases Treated by Programmed Cell Death Receptor-1 and Lenvatinib. lenvatinib 158-168 fibrinogen beta chain Homo sapiens 42-52 34675546-1 2021 Background: This cohort study aimed to investigate the influence of fibrinogen on progression-free survival and overall survival in unresectable HCC cases treated by PD-1 and lenvatinib. lenvatinib 175-185 fibrinogen beta chain Homo sapiens 68-78 34339807-0 2021 Hypochlorite-induced oxidation of fibrinogen: Effects on its thermal denaturation and fibrin structure. Hypochlorous Acid 0-12 fibrinogen beta chain Homo sapiens 34-44 34339807-3 2021 METHODS: For the first time, by differential scanning calorimetry, dynamic and elastic light scattering and confocal laser scanning microscopy, the consequences of HOCl/-OCl-induced oxidation of fibrinogen on its thermal denaturation, molecular size distribution and fibrin clot network have been explored. Hypochlorous Acid 164-168 fibrinogen beta chain Homo sapiens 195-205 34339807-3 2021 METHODS: For the first time, by differential scanning calorimetry, dynamic and elastic light scattering and confocal laser scanning microscopy, the consequences of HOCl/-OCl-induced oxidation of fibrinogen on its thermal denaturation, molecular size distribution and fibrin clot network have been explored. ocl 170-173 fibrinogen beta chain Homo sapiens 195-205 34339807-5 2021 HOCl/-OCl-induced oxidation of fibrinogen resulted in the diminished thermal stability of regions D and E. As evidenced by elastic light scattering and confocal laser scanning microscopy, HOCl/-OCl caused the formation of abnormal fibrin with a decreased diameter of individual fibres. Hypochlorous Acid 0-4 fibrinogen beta chain Homo sapiens 31-41 34339807-5 2021 HOCl/-OCl-induced oxidation of fibrinogen resulted in the diminished thermal stability of regions D and E. As evidenced by elastic light scattering and confocal laser scanning microscopy, HOCl/-OCl caused the formation of abnormal fibrin with a decreased diameter of individual fibres. ocl 6-9 fibrinogen beta chain Homo sapiens 31-41 34339807-5 2021 HOCl/-OCl-induced oxidation of fibrinogen resulted in the diminished thermal stability of regions D and E. As evidenced by elastic light scattering and confocal laser scanning microscopy, HOCl/-OCl caused the formation of abnormal fibrin with a decreased diameter of individual fibres. Hypochlorous Acid 188-192 fibrinogen beta chain Homo sapiens 31-41 34339807-5 2021 HOCl/-OCl-induced oxidation of fibrinogen resulted in the diminished thermal stability of regions D and E. As evidenced by elastic light scattering and confocal laser scanning microscopy, HOCl/-OCl caused the formation of abnormal fibrin with a decreased diameter of individual fibres. ocl 194-197 fibrinogen beta chain Homo sapiens 31-41 34339807-8 2021 GENERAL SIGNIFICANCE: The experimental findings acquired in the current study could help to elucidate the consequences of oxidative stress in vivo on damage to the structure of fibrinogen/fibrin under the action of different ROS species. ros 225-228 fibrinogen beta chain Homo sapiens 177-187 34650023-5 2021 Fibrinogen was treated with MASP-1 followed by analysis on SDS-PAGE and the obtained cleaved fragments were identified by matrix-assisted laser desorption/ionization-time of flight/time of flight. Sodium Dodecyl Sulfate 59-62 fibrinogen beta chain Homo sapiens 0-10 34765272-0 2021 Engineered polymer nanoparticles incorporating l-amino acid groups as affinity reagents for fibrinogen. Polymers 11-18 fibrinogen beta chain Homo sapiens 92-102 34765272-1 2021 Synthetic polymer hydrogel nanoparticles (NPs) were developed to function as abiotic affinity reagents for fibrinogen. Polymers 10-17 fibrinogen beta chain Homo sapiens 107-117 34765272-4 2021 After incubating the NPs with fibrinogen, gamma-globulin, and human serum albumin (HSA) respectively, the NPs that incorporated N-acryloyl-Arg monomers (AArg@NPs) showed the strongest and most specific binding affinity to fibrinogen, when compared with gamma-globulin and HSA. n-acryloyl-arg 128-142 fibrinogen beta chain Homo sapiens 222-232 34800258-7 2021 After adjustments for baseline parameters, the decrease in pH and base excess (BE) values were associated with a decrease in fibrinogen levels (mean decrease of fibrinogen level = 14.88 mg/dL per 0.1 unit reduction of pH values and 3.6 mg/dL per 1 mmol/L reduction of BE levels) and an increase in red blood cells transfusion (2.16 units of RBC per 0.1 unit reduction of pH and 0.38 units of RBC per 1 mmol/L reduction of BE levels). Beryllium 79-81 fibrinogen beta chain Homo sapiens 125-135 34800258-7 2021 After adjustments for baseline parameters, the decrease in pH and base excess (BE) values were associated with a decrease in fibrinogen levels (mean decrease of fibrinogen level = 14.88 mg/dL per 0.1 unit reduction of pH values and 3.6 mg/dL per 1 mmol/L reduction of BE levels) and an increase in red blood cells transfusion (2.16 units of RBC per 0.1 unit reduction of pH and 0.38 units of RBC per 1 mmol/L reduction of BE levels). Beryllium 79-81 fibrinogen beta chain Homo sapiens 161-171 34532747-10 2021 The results showed that mean platelet volume, platelet distribution width, platelet aggregation rate, platelet P selectin, fibrinogen, plasminogen activator inhibitor-1 (PAI-1), thromboxane B2 (TXB2), 6-keto-prostaglandin F1alpha (6-keto-PGF1 alpha), and TXB2/6-keto-PGF1 alpha were higher in the BSS group than in the NBSS group (P<0.05 or P<0.01). nbss 319-323 fibrinogen beta chain Homo sapiens 123-133 34409492-7 2021 RESULTS: Compared with single-dose TXA, patients received three dose TXA had significantly reduced WBC counts and fibrinogen/fibrin degradation product (FDP) levels, increased albumin and fibrinogen levels, and prolonged PT on post-operative day (POD) three. Tranexamic Acid 69-72 fibrinogen beta chain Homo sapiens 114-124 34409492-7 2021 RESULTS: Compared with single-dose TXA, patients received three dose TXA had significantly reduced WBC counts and fibrinogen/fibrin degradation product (FDP) levels, increased albumin and fibrinogen levels, and prolonged PT on post-operative day (POD) three. Tranexamic Acid 69-72 fibrinogen beta chain Homo sapiens 188-198 34409492-11 2021 CONCLUSION: Three-dose TXA contribute to attenuate early post-operative systemic inflammatory response and nutritional loss, increase fibrinogen, reduce FDP levels, and prolong PT in THA patients within an ERAS pathway, which may associate with reduced early post-operative haemorrhagic tendency, thrombosis risks, and hypercoagulability. Tranexamic Acid 23-26 fibrinogen beta chain Homo sapiens 134-144 34321400-9 2021 Although lisinopril reduced systolic and diastolic blood pressure, UACR, hsCRP and fibrinogen in both study groups, these effects were stronger in group B than in group A. Lisinopril 9-19 fibrinogen beta chain Homo sapiens 83-93 34321400-11 2021 The impact of lisinopril on uric acid, hsCRP, fibrinogen, homocysteine and UACR correlated weakly with its hypotensive properties, androgen levels and insulin sensitivity. Lisinopril 14-24 fibrinogen beta chain Homo sapiens 46-56 34509666-6 2021 Basal cortisol levels correlated positively with fibrinogen (r = 0.4503; P = 0.0355) and negatively with AT activity (r = -0.4580; P = 0.0280). Hydrocortisone 6-14 fibrinogen beta chain Homo sapiens 49-59 34682825-4 2021 Therefore, the aim of this study is to examine the time course of fibrinogen level changes during tigecycline therapy in critically ill patients. Tigecycline 98-109 fibrinogen beta chain Homo sapiens 66-76 34682825-8 2021 Patients with a greater fibrinogen decrease received a higher dose, a longer treatment and more dose changes of tigecycline, respectively. Tigecycline 112-123 fibrinogen beta chain Homo sapiens 24-34 34152599-13 2021 On admission to the ICU, fibrinogen was higher in children receiving FC/PCC, namely 232mg/dL (196, 280), than in children receiving FFP (186mg/dL, 149, 224; p<0.001). Fc(alpha) receptor 69-71 fibrinogen beta chain Homo sapiens 25-35 34433211-9 2021 Further, logistics regression analysis showed an association of 25(OH)D with MCP-1, hematocrit, fibrinogen, and blood viscosity. 25(oh)d 64-71 fibrinogen beta chain Homo sapiens 96-106 34098395-10 2021 MAIN RESULTS: Fibrinogen significantly decreased the volume of blood loss (p < 0.001) and the total number of transfused packed-cell units per group (38 vs. 115 units); and compensated the decrease of HCO3 (p = 0.030), the mean arterial pressure (p < 0.001), hemoglobin O2 saturation (p = 0.001), heart rate (p < 0.001), and temperature (p < 0.001) throughout the surgery compared with the placebo. Bicarbonates 201-205 fibrinogen beta chain Homo sapiens 14-24 34098395-10 2021 MAIN RESULTS: Fibrinogen significantly decreased the volume of blood loss (p < 0.001) and the total number of transfused packed-cell units per group (38 vs. 115 units); and compensated the decrease of HCO3 (p = 0.030), the mean arterial pressure (p < 0.001), hemoglobin O2 saturation (p = 0.001), heart rate (p < 0.001), and temperature (p < 0.001) throughout the surgery compared with the placebo. Oxygen 270-272 fibrinogen beta chain Homo sapiens 14-24 34623243-5 2021 In the coagulation pathway, the change ratio of fibrinogen concentration, prothrombin time, and fibrinogen thromboelastometry-maximum clot firmness (FIBTEM-MCF) significantly correlated with HES (P < 0.001, P = 0.00131, and P < 0.001, respectively), but not with crystalloid. Helium 191-194 fibrinogen beta chain Homo sapiens 48-58 34623243-5 2021 In the coagulation pathway, the change ratio of fibrinogen concentration, prothrombin time, and fibrinogen thromboelastometry-maximum clot firmness (FIBTEM-MCF) significantly correlated with HES (P < 0.001, P = 0.00131, and P < 0.001, respectively), but not with crystalloid. Helium 191-194 fibrinogen beta chain Homo sapiens 96-106 34677453-6 2021 The sulfated polysaccharide exhibited potent anticoagulant activity in vitro and in vivo as evaluated by activated partial thromboplastin time (APTT), thrombin time, and the fibrinogen level. sulfated polysaccharide 4-27 fibrinogen beta chain Homo sapiens 174-184 34286724-5 2021 We studied the interactions of PMPC-lipids with plasma albumin, human complement protein C3 and fibrinogen using a quartz crystal microbalance with energy dissipation, and found that adsorption of albumin, C3 and fibrinogen could be suppressed by coating with PMPC-lipids. pmpc-lipids 260-271 fibrinogen beta chain Homo sapiens 213-223 34347419-5 2021 The results demonstrated nearly a 20-fold reduction in fibrinogen adsorption on zwitterionic thin films photografted on polydimethylsiloxane (PDMS) across a wide range of cross-link densities. baysilon 120-140 fibrinogen beta chain Homo sapiens 55-65 34347419-5 2021 The results demonstrated nearly a 20-fold reduction in fibrinogen adsorption on zwitterionic thin films photografted on polydimethylsiloxane (PDMS) across a wide range of cross-link densities. baysilon 142-146 fibrinogen beta chain Homo sapiens 55-65 34286724-5 2021 We studied the interactions of PMPC-lipids with plasma albumin, human complement protein C3 and fibrinogen using a quartz crystal microbalance with energy dissipation, and found that adsorption of albumin, C3 and fibrinogen could be suppressed by coating with PMPC-lipids. poly(2-methacryloyloxyethyl-phosphorylcholine) 31-36 fibrinogen beta chain Homo sapiens 96-106 34286724-5 2021 We studied the interactions of PMPC-lipids with plasma albumin, human complement protein C3 and fibrinogen using a quartz crystal microbalance with energy dissipation, and found that adsorption of albumin, C3 and fibrinogen could be suppressed by coating with PMPC-lipids. poly(2-methacryloyloxyethyl-phosphorylcholine) 31-36 fibrinogen beta chain Homo sapiens 213-223 34467402-10 2021 There were trends towards more rapid reductions in C-reactive protein, D-dimer, fibrinogen and ferritin levels in the fostamatinib group. fostamatinib 118-130 fibrinogen beta chain Homo sapiens 80-90 34286724-5 2021 We studied the interactions of PMPC-lipids with plasma albumin, human complement protein C3 and fibrinogen using a quartz crystal microbalance with energy dissipation, and found that adsorption of albumin, C3 and fibrinogen could be suppressed by coating with PMPC-lipids. pmpc-lipids 260-271 fibrinogen beta chain Homo sapiens 96-106 34476733-12 2022 CONCLUSIONS: Elevated fibrinogen and enlarged LA were independent risk factors for LAT/LASEC in NVAF patients with low CHA2DS2-VASc scores. lasec 87-92 fibrinogen beta chain Homo sapiens 22-32 34218987-8 2021 Similarly, FE induced a significant rise in TNFalpha, TF, fibrinogen, and PAI-1 (P-time<0.05); these parameters remained unchanged under LF and CE (P-time>0.05). Iron 11-13 fibrinogen beta chain Homo sapiens 58-68 34501379-9 2021 Fibrinogen increased by 83 or 107 mg.dL-1 and FibA10 by 4 or 4.5 mm after single or double dose of FC, respectively. Fc(alpha) receptor 99-101 fibrinogen beta chain Homo sapiens 0-10 34497891-0 2021 Human Fibrinogen Inhibits Amyloid Assembly of Most Phenol-Soluble Modulins from Staphylococcus aureus. Phenol 51-57 fibrinogen beta chain Homo sapiens 6-16 34447779-0 2021 Certain Associations Between Iron Biomarkers and Total and gamma" Fibrinogen and Plasma Clot Properties Are Mediated by Fibrinogen Genotypes. Iron 29-33 fibrinogen beta chain Homo sapiens 120-130 34323495-3 2021 By combining nonresonant second-harmonic light scattering with a modified Langmuir model, we show that it is possible to gain insight into the adsorption behavior of blood proteins, namely fibrinogen, human serum albumin, and transferrin, onto negatively charged polystyrene nanoparticles. Polystyrenes 263-274 fibrinogen beta chain Homo sapiens 189-199 34447779-16 2021 Conclusion: This is the first large-scale epidemiological study to relate fibrinogen concentration and functionality to markers of iron status and to take genetic factors into consideration. Iron 131-135 fibrinogen beta chain Homo sapiens 74-84 34447779-17 2021 We have detected a relationship between iron biomarkers and fibrinogen as well as clot characteristics that are influenced by the genetic make-up of an individual. Iron 40-44 fibrinogen beta chain Homo sapiens 60-70 34532445-10 2021 The mutation truncated the gamma-peptide chain and destroyed the functional structure of fibrinogen, including the gamma352Cys-gamma365Cys disulfide bond. gamma352cys 115-126 fibrinogen beta chain Homo sapiens 89-99 34532445-10 2021 The mutation truncated the gamma-peptide chain and destroyed the functional structure of fibrinogen, including the gamma352Cys-gamma365Cys disulfide bond. gamma365cys 127-138 fibrinogen beta chain Homo sapiens 89-99 34532445-10 2021 The mutation truncated the gamma-peptide chain and destroyed the functional structure of fibrinogen, including the gamma352Cys-gamma365Cys disulfide bond. Disulfides 139-148 fibrinogen beta chain Homo sapiens 89-99 34367840-14 2021 In addition, fibrinogen levels showed a positive correlation with important functional indices and prognostic markers such as BODE, ADO, and DOSE indices and a negative correlation with lung function. beta-apocarotenoid-14',13'-dioxygenase 132-135 fibrinogen beta chain Homo sapiens 13-23 34344919-2 2021 We have reported impairment of fibrin polymerization after exposure to hypochlorous acid (HOCl) and increased methionine oxidation of fibrinogen in severely injured trauma patients. Methionine 110-120 fibrinogen beta chain Homo sapiens 134-144 34344919-4 2021 However, experimental evidence explaining how HOCl oxidation impairs fibrinogen structure and function has not been demonstrated. Hypochlorous Acid 46-50 fibrinogen beta chain Homo sapiens 69-79 34344919-5 2021 We utilized polymerization studies and two dimensional-nuclear magnetic resonance spectrometry (2D-NMR) to investigate the hypothesis that HOCl oxidation alters fibrinogen conformation and T2 relaxation time of water protons in the fibrin gels. Hypochlorous Acid 139-143 fibrinogen beta chain Homo sapiens 161-171 34344919-6 2021 We have demonstrated that both HOCl oxidation of purified fibrinogen and addition of HOCl-oxidized fibrinogen to plasma fibrinogen solution disrupted lateral aggregation of protofibrils similarly to competitive inhibition of fibrin polymerization using a recombinant AalphaC fragment (AalphaC 419-502). Hypochlorous Acid 31-35 fibrinogen beta chain Homo sapiens 58-68 34344919-6 2021 We have demonstrated that both HOCl oxidation of purified fibrinogen and addition of HOCl-oxidized fibrinogen to plasma fibrinogen solution disrupted lateral aggregation of protofibrils similarly to competitive inhibition of fibrin polymerization using a recombinant AalphaC fragment (AalphaC 419-502). Hypochlorous Acid 85-89 fibrinogen beta chain Homo sapiens 99-109 34344919-6 2021 We have demonstrated that both HOCl oxidation of purified fibrinogen and addition of HOCl-oxidized fibrinogen to plasma fibrinogen solution disrupted lateral aggregation of protofibrils similarly to competitive inhibition of fibrin polymerization using a recombinant AalphaC fragment (AalphaC 419-502). Hypochlorous Acid 85-89 fibrinogen beta chain Homo sapiens 120-130 34361562-5 2021 These properties of the extracted polyphenols in interaction with the main serum proteins in the human metabolism (human serum albumin (HSA), alpha-beta-globulin (alpha-beta G) and fibrinogen (Fgn)), showed that kiwifruit was more reactive than persimmon. Polyphenols 34-45 fibrinogen beta chain Homo sapiens 181-191 34366869-7 2021 In addition, matrine-treated platelets presented significantly decreased spreading on fibrinogen or collagen and clot retraction along with reduced phosphorylation of c-Src. matrine 13-20 fibrinogen beta chain Homo sapiens 86-96 34440064-8 2021 We found some little difference in the behaviour of the three treatments on some variables: olmesartan was the most effective in reducing fibrinogen, DBP, CRP, and AIx (-13.1%, -19.3%, -21.4%, and -56.8%, respectively). olmesartan 92-102 fibrinogen beta chain Homo sapiens 138-148 34262279-7 2021 Multivariate linear regression analyses showed that an increased serum fibrinogen level (Sbeta = 0.114, p = 0.005) was associated with higher Centre for Epidemiological Studies-Depression (CES-D) scores after adjustment for age, sex, body mass index (BMI), ethnicity, education, marital status, smoking, alcohol use, exercise, perceived stress score, and cardiovascular disease (CVD). Alcohols 304-311 fibrinogen beta chain Homo sapiens 71-81 34223767-7 2021 Since this specific Fib adsorption observed only onto PGD is suppressed in the cases of a mixed solution of HSA and Fib or sequentially using HSA solution and then Fib solution, it is thought that the Vroman effect is suppressed on the PGD-modified surface. pgd 54-57 fibrinogen beta chain Homo sapiens 20-23 34223767-7 2021 Since this specific Fib adsorption observed only onto PGD is suppressed in the cases of a mixed solution of HSA and Fib or sequentially using HSA solution and then Fib solution, it is thought that the Vroman effect is suppressed on the PGD-modified surface. pgd 54-57 fibrinogen beta chain Homo sapiens 116-119 34223767-9 2021 Because of this, the nanometer scale roughness that is significantly observed only on the PGD-modified surface is thought to have an effect on the characteristic adsorption properties of Fib. pgd 90-93 fibrinogen beta chain Homo sapiens 187-190 34285470-7 2021 Pearson correlation analysis showed that the changes in platelet aggregation rates (Delta EPI and DeltaAA) of the patients in the case group after 8 weeks of exenatide treatment were positively correlated with the changes in body mass index, waist circumference, weight, blood lipids, fasting plasma glucose, haemoglobin A1c, fibrinogen, CD62p, and PAC-1 and negatively correlated with the changes in high-density lipoprotein and NO (p<0.05). Exenatide 158-167 fibrinogen beta chain Homo sapiens 326-336 34426920-0 2021 Effect of Hypochlorite- and Peroxide-Induced Oxidation of Fibrinogen on the Fibrin Structure. Hypochlorous Acid 10-22 fibrinogen beta chain Homo sapiens 58-68 34221397-19 2021 The biological findings found average of white blood cells at 12256/12082 e/mm3, lymphocytes at 761/842 e/mm3, CRP at 181/199 mg/L, ferritin at 1747/528 mug/L, and fibrinogen at 6.92/6.27 g/L for the TCZ group versus NON TCZ group. tioconazole 200-203 fibrinogen beta chain Homo sapiens 164-174 34426920-0 2021 Effect of Hypochlorite- and Peroxide-Induced Oxidation of Fibrinogen on the Fibrin Structure. Peroxides 28-36 fibrinogen beta chain Homo sapiens 58-68 34426920-1 2021 Using the methods of dynamic and elastic light scattering and confocal laser scanning microscopy, the damage in the spatial fibrin structure during peroxide- and hypochlorite-induced oxidation of fibrinogen was studied. Peroxides 148-156 fibrinogen beta chain Homo sapiens 196-206 34426920-1 2021 Using the methods of dynamic and elastic light scattering and confocal laser scanning microscopy, the damage in the spatial fibrin structure during peroxide- and hypochlorite-induced oxidation of fibrinogen was studied. Hypochlorous Acid 162-174 fibrinogen beta chain Homo sapiens 196-206 34089882-6 2021 RESULTS: The plasma levels of fibrinogen, D-dimer, ESR, and CRP were significantly lower in the AL group, with an area under the curve of 0.848, 0.669, 0.865, and 0.841, respectively. Aluminum 96-98 fibrinogen beta chain Homo sapiens 30-40 34307676-15 2021 Conclusions: In addition to the routine basic treatment of acute large-area cerebral infarction, the addition of Shenxiong glucose injection combined with edaravone injection can improve platelet aggregation and reduce inflammation by affecting P-selectin, D-dimer, and FIB. Glucose 123-130 fibrinogen beta chain Homo sapiens 270-273 34269459-10 2021 RESULTS: In vitro characteristics show that PRT-treatment leads to increased levels of hemolysis, potassium, and lactate, while there are decreased levels of glucose, FVIII, and fibrinogen after 24 h of storage. PR Toxin 44-47 fibrinogen beta chain Homo sapiens 178-188 34288440-9 2021 For monitoring the heparin anticoagulant therapy, the anti-Xa assay is suggested, because the severe acute-phase reaction (high fibrinogen and high factor VIII) shortens the aPTT. Heparin 19-26 fibrinogen beta chain Homo sapiens 128-138 34209363-10 2021 In addition, mulberroside C inhibited thromboxane A2 production, fibrinogen binding, and clot retraction. mulberroside A 13-27 fibrinogen beta chain Homo sapiens 65-75 34307676-15 2021 Conclusions: In addition to the routine basic treatment of acute large-area cerebral infarction, the addition of Shenxiong glucose injection combined with edaravone injection can improve platelet aggregation and reduce inflammation by affecting P-selectin, D-dimer, and FIB. Edaravone 155-164 fibrinogen beta chain Homo sapiens 270-273 34234486-7 2021 Serum TBA was negatively associated with glycated hemoglobin A1C, plateletcrit, fibrinogen, urine albumin-to-creatinine ratio, vibration perception thresholds, and prevalence of DPN, peripheral arterial disease, and diabetic foot ulceration after adjustment for age, sex, and body mass index (P<0.01 or P<0.05). tba 6-9 fibrinogen beta chain Homo sapiens 80-90 34162972-5 2021 Moreover, addition of CASIN to washed human platelets inhibited platelet spreading on immobilized fibrinogen. CASIN 22-27 fibrinogen beta chain Homo sapiens 98-108 34133479-10 2021 The levels of PAG and FIB in the tirofiban/ozagrel group were significantly lower than those in the tirofiban and ozagrel groups at 24h and 7 days after treatment (p<0.05). Tirofiban 33-42 fibrinogen beta chain Homo sapiens 22-25 34133479-10 2021 The levels of PAG and FIB in the tirofiban/ozagrel group were significantly lower than those in the tirofiban and ozagrel groups at 24h and 7 days after treatment (p<0.05). ozagrel 43-50 fibrinogen beta chain Homo sapiens 22-25 34081446-5 2021 The poly(n-butyl methacrylate70-co-2-(N-methylacetamido)ethyl methacrylate30) (coPAEM) coatings significantly suppressed plasma protein adsorption, denaturation degree of adsorbed fibrinogen, and platelet adhesion. poly(n-butyl methacrylate70-co-2-(n-methylacetamido)ethyl methacrylate30) 4-77 fibrinogen beta chain Homo sapiens 180-190 34133479-14 2021 CONCLUSION: The combination of tirofiban and ozagrel, as well as monotherapy with either tirofiban or ozagrel, transiently improves the neural function of patients and reduces platelet aggregation and fibrinogen formation in the first 4 weeks following a stroke event; additionally, none of these treatments increased the risk for hemorrhage in these progressive stroke patients over a 3-month period. Tirofiban 31-40 fibrinogen beta chain Homo sapiens 201-211 34081446-5 2021 The poly(n-butyl methacrylate70-co-2-(N-methylacetamido)ethyl methacrylate30) (coPAEM) coatings significantly suppressed plasma protein adsorption, denaturation degree of adsorbed fibrinogen, and platelet adhesion. copaem 79-85 fibrinogen beta chain Homo sapiens 180-190 34133479-14 2021 CONCLUSION: The combination of tirofiban and ozagrel, as well as monotherapy with either tirofiban or ozagrel, transiently improves the neural function of patients and reduces platelet aggregation and fibrinogen formation in the first 4 weeks following a stroke event; additionally, none of these treatments increased the risk for hemorrhage in these progressive stroke patients over a 3-month period. ozagrel 45-52 fibrinogen beta chain Homo sapiens 201-211 34133479-14 2021 CONCLUSION: The combination of tirofiban and ozagrel, as well as monotherapy with either tirofiban or ozagrel, transiently improves the neural function of patients and reduces platelet aggregation and fibrinogen formation in the first 4 weeks following a stroke event; additionally, none of these treatments increased the risk for hemorrhage in these progressive stroke patients over a 3-month period. Tirofiban 89-98 fibrinogen beta chain Homo sapiens 201-211 34133479-14 2021 CONCLUSION: The combination of tirofiban and ozagrel, as well as monotherapy with either tirofiban or ozagrel, transiently improves the neural function of patients and reduces platelet aggregation and fibrinogen formation in the first 4 weeks following a stroke event; additionally, none of these treatments increased the risk for hemorrhage in these progressive stroke patients over a 3-month period. ozagrel 102-109 fibrinogen beta chain Homo sapiens 201-211 34188685-10 2021 A similar improvement was achieved with only 0.7 mg/mL chitosan-silica, which highlighted the contribution of hydrophilic chitosan chains to fibrinogen crosslinking. Chitosan 55-63 fibrinogen beta chain Homo sapiens 141-151 34169424-1 2021 Recombinant batroxobin (S3101) is a thrombin-like serine protease that binds to fibrinogen or is taken up by the reticuloendothelial system. Serine 50-56 fibrinogen beta chain Homo sapiens 80-90 34073002-4 2021 We performed a combination of experiments and multi-scale molecular modeling to understand the binding of FBG in vacuum and water-solvated surfaces of LNO. lithium niobate 151-154 fibrinogen beta chain Homo sapiens 106-109 34061194-7 2021 CONCLUSIONS: Risk factors for heparin resistance include antithrombin deficiency, elevation of factor VIII or fibrinogen level, elevation in heparin-binding proteins, increased heparin clearance, sepsis, trauma, and burns. Heparin 30-37 fibrinogen beta chain Homo sapiens 110-120 34073002-3 2021 In this study, single-crystal LiNbO3 (LNO) substrates that have surface charges were used to investigate the adsorption of FBG protruding polar fragments on the positively and negatively charged LNO surfaces. lithium niobate 30-36 fibrinogen beta chain Homo sapiens 123-126 34073002-3 2021 In this study, single-crystal LiNbO3 (LNO) substrates that have surface charges were used to investigate the adsorption of FBG protruding polar fragments on the positively and negatively charged LNO surfaces. lithium niobate 38-41 fibrinogen beta chain Homo sapiens 123-126 34073002-3 2021 In this study, single-crystal LiNbO3 (LNO) substrates that have surface charges were used to investigate the adsorption of FBG protruding polar fragments on the positively and negatively charged LNO surfaces. lithium niobate 195-198 fibrinogen beta chain Homo sapiens 123-126 34073002-4 2021 We performed a combination of experiments and multi-scale molecular modeling to understand the binding of FBG in vacuum and water-solvated surfaces of LNO. Water 124-129 fibrinogen beta chain Homo sapiens 106-109 34069309-3 2021 An enzyme-linked immunosorbent assay demonstrated that synthesis of gammaY278H fibrinogen inside CHO cells and secretion into the culture media were not reduced. gammay278h 68-78 fibrinogen beta chain Homo sapiens 79-89 34061326-8 2021 Plasma fibrinogen concentration significantly correlated with HbA1c (Spearman"s correlation coefficient (r) = 0.54) and HDL cholesterol (r = - 0.67). Cholesterol 124-135 fibrinogen beta chain Homo sapiens 7-17 35123976-7 2022 RESULTS: Strong correlations and acceptable variations, using the TEa as decision limit, were found for INR, PT, TT, fibrinogen, and D-dimer between capillary and venous sampling. tea 66-69 fibrinogen beta chain Homo sapiens 117-127 35485613-7 2022 An atomic force microscope using protein- or antibody-conjugated cantilevers was used to perform nanoscopic analyses of the adsorption forces and conformational changes in fibrinogen and fibronectin adsorbed on the nanometer-scale PMEA structures. poly(2-methoxyethylacrylate) 231-235 fibrinogen beta chain Homo sapiens 172-182 34073002-5 2021 XPS measurements showed that the FBG adsorption on LNO increased with increment in solution concentration on surfaces independent of charges. lithium niobate 51-54 fibrinogen beta chain Homo sapiens 33-36 34073002-6 2021 Multi-scale molecular modeling employing Quantum Mechanics, Monte Carlo, and Molecular Mechanics addressed the phenomenon of FBG fragment bonding on LNO surfaces. lithium niobate 149-152 fibrinogen beta chain Homo sapiens 125-128 35583079-0 2022 The antimicrobial effect of calcium-doped titanium is activated by fibrinogen adsorption. Calcium 28-35 fibrinogen beta chain Homo sapiens 67-77 35583079-2 2022 Herein, we report an unexpected antimicrobial effect of calcium-doped titanium, which itself has no apparent killing effect on the growth of pathogenic bacteria (Pseudomonas aeruginosa, Pa, ATCC 27853) while presenting strong inhibition efficiency on bacterial colonization after fibrinogen adsorption onto the material. Calcium 56-63 fibrinogen beta chain Homo sapiens 280-290 35583079-3 2022 Fine X-ray photoelectron spectroscopy and Fourier-transform infrared spectroscopy analyses reported calcium-dependent shifts of the binding energy in nitrogen and oxygen involved groups and wavenumbers in the amide I and II bands of the adsorbent fibrinogen, demonstrating that locally delivered calcium can react with the carboxy-terminal regions of the Aalpha chains and influence their interaction with the N-termini of the Bbeta chains in fibrinogen. Calcium 100-107 fibrinogen beta chain Homo sapiens 247-257 35583079-2 2022 Herein, we report an unexpected antimicrobial effect of calcium-doped titanium, which itself has no apparent killing effect on the growth of pathogenic bacteria (Pseudomonas aeruginosa, Pa, ATCC 27853) while presenting strong inhibition efficiency on bacterial colonization after fibrinogen adsorption onto the material. Titanium 70-78 fibrinogen beta chain Homo sapiens 280-290 35583079-3 2022 Fine X-ray photoelectron spectroscopy and Fourier-transform infrared spectroscopy analyses reported calcium-dependent shifts of the binding energy in nitrogen and oxygen involved groups and wavenumbers in the amide I and II bands of the adsorbent fibrinogen, demonstrating that locally delivered calcium can react with the carboxy-terminal regions of the Aalpha chains and influence their interaction with the N-termini of the Bbeta chains in fibrinogen. Calcium 100-107 fibrinogen beta chain Homo sapiens 443-453 35583079-3 2022 Fine X-ray photoelectron spectroscopy and Fourier-transform infrared spectroscopy analyses reported calcium-dependent shifts of the binding energy in nitrogen and oxygen involved groups and wavenumbers in the amide I and II bands of the adsorbent fibrinogen, demonstrating that locally delivered calcium can react with the carboxy-terminal regions of the Aalpha chains and influence their interaction with the N-termini of the Bbeta chains in fibrinogen. Nitrogen 150-158 fibrinogen beta chain Homo sapiens 247-257 35583079-3 2022 Fine X-ray photoelectron spectroscopy and Fourier-transform infrared spectroscopy analyses reported calcium-dependent shifts of the binding energy in nitrogen and oxygen involved groups and wavenumbers in the amide I and II bands of the adsorbent fibrinogen, demonstrating that locally delivered calcium can react with the carboxy-terminal regions of the Aalpha chains and influence their interaction with the N-termini of the Bbeta chains in fibrinogen. Nitrogen 150-158 fibrinogen beta chain Homo sapiens 443-453 35583079-3 2022 Fine X-ray photoelectron spectroscopy and Fourier-transform infrared spectroscopy analyses reported calcium-dependent shifts of the binding energy in nitrogen and oxygen involved groups and wavenumbers in the amide I and II bands of the adsorbent fibrinogen, demonstrating that locally delivered calcium can react with the carboxy-terminal regions of the Aalpha chains and influence their interaction with the N-termini of the Bbeta chains in fibrinogen. Oxygen 163-169 fibrinogen beta chain Homo sapiens 247-257 35583079-3 2022 Fine X-ray photoelectron spectroscopy and Fourier-transform infrared spectroscopy analyses reported calcium-dependent shifts of the binding energy in nitrogen and oxygen involved groups and wavenumbers in the amide I and II bands of the adsorbent fibrinogen, demonstrating that locally delivered calcium can react with the carboxy-terminal regions of the Aalpha chains and influence their interaction with the N-termini of the Bbeta chains in fibrinogen. Amides 209-214 fibrinogen beta chain Homo sapiens 247-257 35583079-3 2022 Fine X-ray photoelectron spectroscopy and Fourier-transform infrared spectroscopy analyses reported calcium-dependent shifts of the binding energy in nitrogen and oxygen involved groups and wavenumbers in the amide I and II bands of the adsorbent fibrinogen, demonstrating that locally delivered calcium can react with the carboxy-terminal regions of the Aalpha chains and influence their interaction with the N-termini of the Bbeta chains in fibrinogen. Amides 209-214 fibrinogen beta chain Homo sapiens 443-453 35583079-3 2022 Fine X-ray photoelectron spectroscopy and Fourier-transform infrared spectroscopy analyses reported calcium-dependent shifts of the binding energy in nitrogen and oxygen involved groups and wavenumbers in the amide I and II bands of the adsorbent fibrinogen, demonstrating that locally delivered calcium can react with the carboxy-terminal regions of the Aalpha chains and influence their interaction with the N-termini of the Bbeta chains in fibrinogen. Calcium 296-303 fibrinogen beta chain Homo sapiens 247-257 35086148-10 2022 Plasma levels of fibrinogen, antithrombin, protein C and TFPI decreased, and free protein S increased in tamoxifen, but not in AI, users. Tamoxifen 105-114 fibrinogen beta chain Homo sapiens 17-27 35547600-2 2022 The present study aimed to evaluate the predictive ability of the fibrinogen-albumin ratio index (FARI) to the efficacy of neoadjuvant chemotherapy (NAC) for osteosarcoma. nac 149-152 fibrinogen beta chain Homo sapiens 66-76 35147244-6 2022 Fluorescence experiment showed that HY023016 remarkably inhibited exosite II by a loss of affinity for the gamma"-peptide of fibrinogen. HY023016 36-44 fibrinogen beta chain Homo sapiens 125-135 35514052-6 2022 RESULTS: Under low-shear, LIS preserved fibrinogen concentration in blood relative to control polymers (+40 +- 6 mg/dL vs polyvinyl chloride, p < .0001), suggesting protein adsorption was minimized. lis 26-29 fibrinogen beta chain Homo sapiens 40-50 35514052-6 2022 RESULTS: Under low-shear, LIS preserved fibrinogen concentration in blood relative to control polymers (+40 +- 6 mg/dL vs polyvinyl chloride, p < .0001), suggesting protein adsorption was minimized. Polyvinyl Chloride 122-140 fibrinogen beta chain Homo sapiens 40-50 35514052-7 2022 A fibrinogen adhesion assay demonstrated a dramatic reduction in protein adsorption under low shear (87% decrease vs polyvinyl chloride, p = .01). Polyvinyl Chloride 117-135 fibrinogen beta chain Homo sapiens 2-12 35508533-0 2022 Designing a new alginate-fibrinogen biomaterial composite hydrogel for wound healing. Alginates 16-24 fibrinogen beta chain Homo sapiens 25-35 35508533-4 2022 Biophysical characterization showed that the interaction of fibrinogen and alginate was associated with minor changes in the secondary structure of the protein. Alginates 75-83 fibrinogen beta chain Homo sapiens 60-70 35129153-8 2022 Instead, in the patients with UC, stratified with the PUCAI, there was a statistically significant difference in serum fibrinogen levels between patients with mild and moderate/severe disease (3.8 (3.2-4.5) g/L vs 5.7 (4.8-6.2) g/L, p < 0.0032).Serum homocysteine levels were lower in healthy controls than in CD (p = 0.176) and UC (p = 0.026). Homocysteine 251-263 fibrinogen beta chain Homo sapiens 119-129 35529262-2 2022 This study is aimed at investigating the efficacy of tirofiban combined with ticagrelor in AMI patients after percutaneous coronary intervention (PCI) and its effects on plasma activated partial thromboplastin time (APTT), fibrinogen (FIB), D-dimer (D-D) levels, myocardial injury markers, and inflammatory factors. Tirofiban 53-62 fibrinogen beta chain Homo sapiens 223-233 35158163-7 2022 Inhibition of mitochondrial superoxide prevented oxidative modification and proteolysis of fibrinogen, whereas inhibition of MPO attenuated only fibrinogen proteolysis. Superoxides 28-38 fibrinogen beta chain Homo sapiens 91-101 35158163-9 2022 Collectively, these findings indicate that neutrophil and monocyte mitochondrial superoxide generation can rapidly oxidize fibrinogen as a priming step for fibrinogen proteolysis and coagulopathy during inflammation. Superoxides 81-91 fibrinogen beta chain Homo sapiens 123-133 35158163-9 2022 Collectively, these findings indicate that neutrophil and monocyte mitochondrial superoxide generation can rapidly oxidize fibrinogen as a priming step for fibrinogen proteolysis and coagulopathy during inflammation. Superoxides 81-91 fibrinogen beta chain Homo sapiens 156-166 35574019-9 2022 Our study revealed that SCH changed the heamostatic balance towards hypercoagulable and hypofibrinolytic conditions accompanied by an increase in tissue fibrinogen, plasminogen activator and plasminogen activator inhibitor-1. sch 24-27 fibrinogen beta chain Homo sapiens 153-163 35529262-2 2022 This study is aimed at investigating the efficacy of tirofiban combined with ticagrelor in AMI patients after percutaneous coronary intervention (PCI) and its effects on plasma activated partial thromboplastin time (APTT), fibrinogen (FIB), D-dimer (D-D) levels, myocardial injury markers, and inflammatory factors. Tirofiban 53-62 fibrinogen beta chain Homo sapiens 235-238 35529262-2 2022 This study is aimed at investigating the efficacy of tirofiban combined with ticagrelor in AMI patients after percutaneous coronary intervention (PCI) and its effects on plasma activated partial thromboplastin time (APTT), fibrinogen (FIB), D-dimer (D-D) levels, myocardial injury markers, and inflammatory factors. Ticagrelor 77-87 fibrinogen beta chain Homo sapiens 223-233 35200041-0 2022 Fibrinogen Mediates Cadmium-induced Macrophage Activation and Serves as a Predictor of Cadmium Exposure in Chronic Obstructive Pulmonary Disease. Cadmium 20-27 fibrinogen beta chain Homo sapiens 0-10 35469231-7 2022 Furthermore, a rescue experiment confirmed miR-139-5p affected the proliferation and angiogenesis of HBMEC through FGB. mir-139-5p 43-53 fibrinogen beta chain Homo sapiens 115-118 35415272-11 2022 Serum concentrations of vitamin D were positively correlated with levels of serum calcium, lymphocytes, and neutrophils but negatively correlated with CRP, fibrinogen, and d-dimer values. Vitamin D 24-33 fibrinogen beta chain Homo sapiens 156-166 35200041-8 2022 We further showed that fibrinogen complexed with connective tissue growth factor (CTGF), which in turn promoted the synthesis of plasminogen activator inhibitor-2 (PAI-2) and fibrinogen, and inhibited fibrinolysis in Cd-treated mice. Cadmium 217-219 fibrinogen beta chain Homo sapiens 23-33 35200041-9 2022 The amounts of fibrinogen were increased in the bronchoalveolar lavage fluid (BALF) of Cd-exposed mice. Cadmium 87-89 fibrinogen beta chain Homo sapiens 15-25 35200041-10 2022 Positive correlations were observed between fibrinogen with hydroxyproline. Hydroxyproline 60-74 fibrinogen beta chain Homo sapiens 44-54 35200041-11 2022 Our data suggests that fibrinogen is involved in Cd-induced macrophage activation and increases in fibrinogen in patients with COPD may be used as a marker of Cd exposure and predict disease progression. Cadmium 49-51 fibrinogen beta chain Homo sapiens 23-33 35200041-11 2022 Our data suggests that fibrinogen is involved in Cd-induced macrophage activation and increases in fibrinogen in patients with COPD may be used as a marker of Cd exposure and predict disease progression. Cadmium 159-161 fibrinogen beta chain Homo sapiens 23-33 35200041-11 2022 Our data suggests that fibrinogen is involved in Cd-induced macrophage activation and increases in fibrinogen in patients with COPD may be used as a marker of Cd exposure and predict disease progression. Cadmium 159-161 fibrinogen beta chain Homo sapiens 99-109 35443419-11 2022 Fibrinogen was also independently associated with poor outcome (odds ratio 1.004, p = 0.038) along with initial NIHSS score and fasting blood sugar level. Sugars 142-147 fibrinogen beta chain Homo sapiens 0-10 35091759-7 2022 The blood metabolite analysis showed a stage-dependent inosine increase in COVID-19 patients, while the nucleotides ATP and ADP had positive correlations with fibrinogen and other coagulation proteins. Adenosine Triphosphate 116-119 fibrinogen beta chain Homo sapiens 159-169 35091759-7 2022 The blood metabolite analysis showed a stage-dependent inosine increase in COVID-19 patients, while the nucleotides ATP and ADP had positive correlations with fibrinogen and other coagulation proteins. Adenosine Diphosphate 124-127 fibrinogen beta chain Homo sapiens 159-169 35236191-8 2022 CONCLUSION: D-D and FIB testing can improve the thrombolysis rate, reduce the risk of bleeding, and decrease the number of angiograms and X-ray radiation dose during CDT. cdt 166-169 fibrinogen beta chain Homo sapiens 20-23 34999047-3 2022 Under in vitro conditions, MG altered the tertiary structure of fibrinogen. Pyruvaldehyde 27-29 fibrinogen beta chain Homo sapiens 64-74 35235295-6 2022 Moreover, the discontinued surface topography of the shish-kebab structure altered the surface chemistry from hydrophobic for the original poly(epsilon-caprolactone) (PCL) nanofibers to hydrophilic for the PCL nanofibers with the shish-kebab structure, which might have inhibited the activation of fibrinogen and thus improved the anticoagulant ability. polycaprolactone 139-165 fibrinogen beta chain Homo sapiens 298-308 35260173-5 2022 The contact of QDs with PTM (prothrombin), PLG (plasminogen) and FIB (fibrinogen) which are primary coagulation-related proteins in the coagulation and fibrinolysis systems formed QDs-protein conjugates through hydrogen-bonding and hydrophobic interaction. Hydrogen 211-219 fibrinogen beta chain Homo sapiens 65-68 35260173-5 2022 The contact of QDs with PTM (prothrombin), PLG (plasminogen) and FIB (fibrinogen) which are primary coagulation-related proteins in the coagulation and fibrinolysis systems formed QDs-protein conjugates through hydrogen-bonding and hydrophobic interaction. Hydrogen 211-219 fibrinogen beta chain Homo sapiens 70-80 35253142-6 2022 Treatment of platelets with cucurbitacins resulted in attenuation of platelet aggregation, secretion and fibrinogen binding following stimulation by ADP, TRAP6, collagen and CRP-XL. Cucurbitacins 28-41 fibrinogen beta chain Homo sapiens 105-115 35253142-6 2022 Treatment of platelets with cucurbitacins resulted in attenuation of platelet aggregation, secretion and fibrinogen binding following stimulation by ADP, TRAP6, collagen and CRP-XL. Adenosine Diphosphate 149-152 fibrinogen beta chain Homo sapiens 105-115 35275281-2 2022 It is a substantial component of isolated fibrinogen (fg), which spontaneously self-assembles into protofibrils progressing to fibers at sub-physiologic temperatures, a process enhanced by adsorption to hydrophobic and some metal surfaces. Metals 224-229 fibrinogen beta chain Homo sapiens 42-52 35200041-0 2022 Fibrinogen Mediates Cadmium-induced Macrophage Activation and Serves as a Predictor of Cadmium Exposure in Chronic Obstructive Pulmonary Disease. Cadmium 87-94 fibrinogen beta chain Homo sapiens 0-10 35200041-5 2022 Fibrinogen concentration also correlated positively with lung Cd load, but inversely with the predicted % of FEV1 and FEV1/FVC. Cadmium 62-64 fibrinogen beta chain Homo sapiens 0-10 35200041-6 2022 Cd enhanced the secretion of fibrinogen in a cdc2-dependent manner whereas fibrinogen further mediated Cd-induced peptidylarginine deiminase 2 (PAD2)-dependent macrophage activation. Cadmium 0-2 fibrinogen beta chain Homo sapiens 29-39 35200041-6 2022 Cd enhanced the secretion of fibrinogen in a cdc2-dependent manner whereas fibrinogen further mediated Cd-induced peptidylarginine deiminase 2 (PAD2)-dependent macrophage activation. Cadmium 103-105 fibrinogen beta chain Homo sapiens 75-85 35200041-7 2022 Using lung fibroblasts from CdCl2-treated toll-like receptor 4 (TLR4) wild type and mutant mice, we demonstrated that fibrinogen enhanced Cd-induced TLR4-dependent collagen synthesis and cytokine/chemokine production. Cadmium Chloride 28-33 fibrinogen beta chain Homo sapiens 118-128 35200041-7 2022 Using lung fibroblasts from CdCl2-treated toll-like receptor 4 (TLR4) wild type and mutant mice, we demonstrated that fibrinogen enhanced Cd-induced TLR4-dependent collagen synthesis and cytokine/chemokine production. Cadmium 138-140 fibrinogen beta chain Homo sapiens 118-128 35270411-5 2022 The efficacy of steroids was investigated in quantitative, oxygen, steroid plus erythropoietin (EPO), levodopa/carbidopa, memantine, and heparin-induced extracorporeal LDL/fibrinogen precipitation (HELP) therapies and other therapeutic modalities in qualitative synthesis. Steroids 16-24 fibrinogen beta chain Homo sapiens 172-182 35353187-8 2022 Single-factor linear regression analysis showed that TBIL and DBIL showed the R2 values were 0.221 and 0.220, and the R2 values of UIBC, FIB, and maximal lesion diameter were 0.157, 0.174, and 0.167, respectively, and those of the remaining indicators were <0.1. Bilirubin 53-57 fibrinogen beta chain Homo sapiens 137-140 35353187-8 2022 Single-factor linear regression analysis showed that TBIL and DBIL showed the R2 values were 0.221 and 0.220, and the R2 values of UIBC, FIB, and maximal lesion diameter were 0.157, 0.174, and 0.167, respectively, and those of the remaining indicators were <0.1. dbil 62-66 fibrinogen beta chain Homo sapiens 137-140 34994377-2 2022 First described in human fibrinogen, tyrosine-O-sulfation has long been associated with the modulation of protein-protein interactions in several physiological processes. Tyrosine 37-45 fibrinogen beta chain Homo sapiens 25-35 35270411-5 2022 The efficacy of steroids was investigated in quantitative, oxygen, steroid plus erythropoietin (EPO), levodopa/carbidopa, memantine, and heparin-induced extracorporeal LDL/fibrinogen precipitation (HELP) therapies and other therapeutic modalities in qualitative synthesis. Heparin 137-144 fibrinogen beta chain Homo sapiens 172-182 35132974-0 2022 Fibrinogen aptamer functionalized gold-coated iron-oxide nanoparticles for targeted imaging of thrombi. ferric oxide 46-56 fibrinogen beta chain Homo sapiens 0-10 34995330-3 2022 PURPOSE: Determine whether fibrinogen heritability (h2) is quantile-specific, and whether quantile-specific h2 could account for fibrinogen gene-environment interactions. Deuterium 108-110 fibrinogen beta chain Homo sapiens 129-139 35252131-6 2022 Currently, tissue engineering has employed several synthetic polymers to design bioactive scaffolds to mimic the native ECM, by combining biopolymers with growth factors including collagen and fibrinogen. Polymers 61-69 fibrinogen beta chain Homo sapiens 180-203 35062908-0 2022 Fibrinogen/albumin ratio as a promising predictor of platinum response and survival in ovarian clear cell carcinoma. Platinum 53-61 fibrinogen beta chain Homo sapiens 0-10 35062908-1 2022 BACKGROUND: This study aims to evaluate the role of the fibrinogen/albumin ratio (FAR) in predicting platinum resistance and survival outcomes of patients with ovarian clear cell carcinoma (OCCC). Platinum 101-109 fibrinogen beta chain Homo sapiens 56-66 2560285-1 1989 2 or 3 daily injections of unfractionated heparin reduce the risk of thrombosis in patients undergoing general surgery from about 39 to 4 to 5% (sodium-fibrinogen-test). Heparin 42-49 fibrinogen beta chain Homo sapiens 152-162 35379386-10 2022 Meta-analysis showed that patients that were vitamin D sufficient (levels >30ng/mL) had statistically significant lower levels of IL-6, CRP, ferritin, LDH, fibrinogen, and D-dimer compared to vitamin D deficient group. Vitamin D 45-54 fibrinogen beta chain Homo sapiens 156-166 2617455-1 1989 This report describes the binding of plasminogen to fibrinogen adsorbed onto polystyrene wells. Polystyrenes 77-88 fibrinogen beta chain Homo sapiens 52-62 2617455-4 1989 However, more lys- than glu-plasminogen bound when equal concentrations of either were added to immobilized fibrinogen. Lysine 14-17 fibrinogen beta chain Homo sapiens 108-118 2617455-8 1989 These studies demonstrate that immobilized fibrinogen binds both glu- and lys-plasminogen and that binding is mediated via lysine-binding regions. Lysine 123-129 fibrinogen beta chain Homo sapiens 43-53 2483162-2 1989 This is applied to the diffusion of porcine serum proteins, gamma-globulin and fibrinogen in Sepharose CL-4B. Sepharose CL 4B 93-108 fibrinogen beta chain Homo sapiens 79-89 35277037-10 2022 In descriptive findings, Mg supplementation significantly reduced plasma fibrinogen, tartrate-resistant acid phosphatase type 5, tumor necrosis factor-ligand superfamily member 13B, ST2 protein, and IL-1. Magnesium 25-27 fibrinogen beta chain Homo sapiens 73-83 2573600-1 1989 The interaction of endothelial cells with soluble or substrate-immobilized 125I-labeled fibrinogen (125I-FGN) was analyzed. Iodine-125 75-79 fibrinogen beta chain Homo sapiens 88-98 2696214-3 1989 One is diagnosing deep venous thrombosis with the 125 (131) iodine-fibrinogen uptake-test. Iodine 60-66 fibrinogen beta chain Homo sapiens 67-77 2573600-5 1989 Calcium-dependent binding was completely inhibited by unlabeled fibrinogen, partially inhibited by a monoclonal antibody (7E3) against glycoprotein IIb-IIIa, but not inhibited by fibrinogen fragments D or E, an anti-glycoprotein IIIa polyclonal antibody, or the Arg-Gly-Asp-Ser tetrapeptide. Calcium 0-7 fibrinogen beta chain Homo sapiens 64-74 2573600-6 1989 In contrast, the Arg-Gly-Asp-Ser tetrapeptide as well as the monoclonal antibody 7E3 markedly inhibited attachment of endothelial cells to substrate-immobilized fibrinogen, whereas fragment D or E did not. Serine 29-32 fibrinogen beta chain Homo sapiens 161-171 2573600-5 1989 Calcium-dependent binding was completely inhibited by unlabeled fibrinogen, partially inhibited by a monoclonal antibody (7E3) against glycoprotein IIb-IIIa, but not inhibited by fibrinogen fragments D or E, an anti-glycoprotein IIIa polyclonal antibody, or the Arg-Gly-Asp-Ser tetrapeptide. Arginine 262-265 fibrinogen beta chain Homo sapiens 64-74 2573600-5 1989 Calcium-dependent binding was completely inhibited by unlabeled fibrinogen, partially inhibited by a monoclonal antibody (7E3) against glycoprotein IIb-IIIa, but not inhibited by fibrinogen fragments D or E, an anti-glycoprotein IIIa polyclonal antibody, or the Arg-Gly-Asp-Ser tetrapeptide. Serine 274-277 fibrinogen beta chain Homo sapiens 64-74 2573600-6 1989 In contrast, the Arg-Gly-Asp-Ser tetrapeptide as well as the monoclonal antibody 7E3 markedly inhibited attachment of endothelial cells to substrate-immobilized fibrinogen, whereas fragment D or E did not. Arginine 17-20 fibrinogen beta chain Homo sapiens 161-171 2573600-6 1989 In contrast, the Arg-Gly-Asp-Ser tetrapeptide as well as the monoclonal antibody 7E3 markedly inhibited attachment of endothelial cells to substrate-immobilized fibrinogen, whereas fragment D or E did not. Glycine 21-24 fibrinogen beta chain Homo sapiens 161-171 2573600-6 1989 In contrast, the Arg-Gly-Asp-Ser tetrapeptide as well as the monoclonal antibody 7E3 markedly inhibited attachment of endothelial cells to substrate-immobilized fibrinogen, whereas fragment D or E did not. Aspartic Acid 25-28 fibrinogen beta chain Homo sapiens 161-171 2819242-2 1989 On sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) run according to the method of Laemmli, we noticed two gamma chain species in fibrinogen and its plasmic fragments D1 and D2, consisting of a normal species and an apparently lower molecular weight (mol wt) variant in respective fractions. Sodium Dodecyl Sulfate 3-25 fibrinogen beta chain Homo sapiens 150-160 2561450-5 1989 The results indicate that human fibrinogen contains tyrosine sulfate primarily within a variant form of the gamma-chain. tyrosine O-sulfate 52-68 fibrinogen beta chain Homo sapiens 32-42 2819242-2 1989 On sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) run according to the method of Laemmli, we noticed two gamma chain species in fibrinogen and its plasmic fragments D1 and D2, consisting of a normal species and an apparently lower molecular weight (mol wt) variant in respective fractions. polyacrylamide 26-40 fibrinogen beta chain Homo sapiens 150-160 2819242-2 1989 On sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) run according to the method of Laemmli, we noticed two gamma chain species in fibrinogen and its plasmic fragments D1 and D2, consisting of a normal species and an apparently lower molecular weight (mol wt) variant in respective fractions. Sodium Dodecyl Sulfate 62-65 fibrinogen beta chain Homo sapiens 150-160 2819242-7 1989 The point mutation from an aspartic acid (pK for the beta-carboxyl = 3.86) to a tyrosine (pK for the aromatic hydroxyl = 10.07) may have perturbed the folding gamma chain structure in the D domain of fibrinogen specifically required for polymerization. Aspartic Acid 27-40 fibrinogen beta chain Homo sapiens 200-210 2819242-7 1989 The point mutation from an aspartic acid (pK for the beta-carboxyl = 3.86) to a tyrosine (pK for the aromatic hydroxyl = 10.07) may have perturbed the folding gamma chain structure in the D domain of fibrinogen specifically required for polymerization. (2-benzoylethyl)trimethylammonium 53-57 fibrinogen beta chain Homo sapiens 200-210 2819242-7 1989 The point mutation from an aspartic acid (pK for the beta-carboxyl = 3.86) to a tyrosine (pK for the aromatic hydroxyl = 10.07) may have perturbed the folding gamma chain structure in the D domain of fibrinogen specifically required for polymerization. Tyrosine 80-88 fibrinogen beta chain Homo sapiens 200-210 2629467-6 1989 Also dihydrocytochalasin B inhibited the second peak of Ca2+ influx by thrombin, suggesting that the signal, which was caused by fibrinogen-binding to GPIIb/IIIa (aggregation) in thrombin-activated platelets, is transferred to the inner sites of GPIIb/IIIa complex and induces the cytoskeletal reorganization such as actin polymerization. dihydrocytochalasin B 5-26 fibrinogen beta chain Homo sapiens 129-139 2559918-0 1989 Preadsorption of polymers on glass and silica to reduce fibrinogen adsorption. Polymers 17-25 fibrinogen beta chain Homo sapiens 56-66 2559918-0 1989 Preadsorption of polymers on glass and silica to reduce fibrinogen adsorption. Silicon Dioxide 39-45 fibrinogen beta chain Homo sapiens 56-66 2559918-4 1989 This ABA type block copolymer, where A is a poly(N-acetylethyleneimine) (PAEI) sequence and B a polyethylene oxide (PEO) sequence was preadsorbed at pH 4.5 and 25 degrees C; the fibrinogen adsorption was reduced to less than 5% of the value observed on untreated solid surfaces. alisol B 23-acetate 5-8 fibrinogen beta chain Homo sapiens 178-188 2559918-4 1989 This ABA type block copolymer, where A is a poly(N-acetylethyleneimine) (PAEI) sequence and B a polyethylene oxide (PEO) sequence was preadsorbed at pH 4.5 and 25 degrees C; the fibrinogen adsorption was reduced to less than 5% of the value observed on untreated solid surfaces. copolymer 20-29 fibrinogen beta chain Homo sapiens 178-188 2559919-8 1989 The efficiency of this precoating to reduce the adsorption of fibrinogen was very high (99.2% reduction with respect to bare silica). Silicon Dioxide 125-131 fibrinogen beta chain Homo sapiens 62-72 2532267-4 1989 In patients with nephrotic syndrome EC50 ADP values were significantly correlated to serum albumin, serum cholesterol and plasma fibrinogen, however, EC50 collagen or threshold AA did not correlate to these parameters. Adenosine Diphosphate 41-44 fibrinogen beta chain Homo sapiens 129-139 2691968-3 1989 It is mediated by the binding of bifunctional molecules of fibrinogen to the plasma membrane of adjacent platelets, following stimulation of the platelets by agonists such as ADP, thrombin or collagen, with the fibrinogen serving as an intercellular glue. Adenosine Diphosphate 175-178 fibrinogen beta chain Homo sapiens 59-69 2691968-3 1989 It is mediated by the binding of bifunctional molecules of fibrinogen to the plasma membrane of adjacent platelets, following stimulation of the platelets by agonists such as ADP, thrombin or collagen, with the fibrinogen serving as an intercellular glue. Adenosine Diphosphate 175-178 fibrinogen beta chain Homo sapiens 211-221 2691968-4 1989 The platelet receptor for fibrinogen is a macromolecular complex, GPIIb-IIIa, made of two transmembrane glycoproteins, GPIIb (Mr = 142,000) and GPIIIa (Mr = 99,000), assembled into a heterodimer whose conformation depends upon the binding of calcium (Ca2+) to GPIIb. Calcium 242-249 fibrinogen beta chain Homo sapiens 26-36 2626743-8 1989 Knowing the amino acid composition and the relative proportions of these fractions, the nitrogen contents of the clots were converted to fibrinogen. Nitrogen 88-96 fibrinogen beta chain Homo sapiens 137-147 2595667-1 1989 The effect of manganese ion (Mn2+) on the aggregation of porcine pancreatic elastase-treated platelets (ETP) induced by fibrinogen (Fbg) was studied. Manganese 14-23 fibrinogen beta chain Homo sapiens 120-130 2595667-1 1989 The effect of manganese ion (Mn2+) on the aggregation of porcine pancreatic elastase-treated platelets (ETP) induced by fibrinogen (Fbg) was studied. Manganese 14-23 fibrinogen beta chain Homo sapiens 132-135 2595667-1 1989 The effect of manganese ion (Mn2+) on the aggregation of porcine pancreatic elastase-treated platelets (ETP) induced by fibrinogen (Fbg) was studied. Manganese(2+) 29-33 fibrinogen beta chain Homo sapiens 120-130 2595667-1 1989 The effect of manganese ion (Mn2+) on the aggregation of porcine pancreatic elastase-treated platelets (ETP) induced by fibrinogen (Fbg) was studied. Manganese(2+) 29-33 fibrinogen beta chain Homo sapiens 132-135 2595667-2 1989 Mn2+ enhanced the aggregation of ETP on addition of Fbg specifically and dose-dependently. Manganese(2+) 0-4 fibrinogen beta chain Homo sapiens 52-55 2595667-5 1989 Studies on the binding of 125I-Fbg to ETP showed that Mn2+ increased the Kd value of binding but did not affect the number of Fbg binding sites. Manganese(2+) 54-58 fibrinogen beta chain Homo sapiens 31-34 2595667-6 1989 These results indicate that Mn2+ specifically and dose-dependently potentiated Fbg-induced aggregation of ETP and that this effect of Mn2+ may be due to an increase in the affinity of binding of Fbg to the glycoprotein IIb-IIIa complex on the membranes of ETP. Manganese(2+) 28-32 fibrinogen beta chain Homo sapiens 79-82 2595667-6 1989 These results indicate that Mn2+ specifically and dose-dependently potentiated Fbg-induced aggregation of ETP and that this effect of Mn2+ may be due to an increase in the affinity of binding of Fbg to the glycoprotein IIb-IIIa complex on the membranes of ETP. Manganese(2+) 28-32 fibrinogen beta chain Homo sapiens 195-198 2595667-6 1989 These results indicate that Mn2+ specifically and dose-dependently potentiated Fbg-induced aggregation of ETP and that this effect of Mn2+ may be due to an increase in the affinity of binding of Fbg to the glycoprotein IIb-IIIa complex on the membranes of ETP. Manganese(2+) 134-138 fibrinogen beta chain Homo sapiens 79-82 2595667-6 1989 These results indicate that Mn2+ specifically and dose-dependently potentiated Fbg-induced aggregation of ETP and that this effect of Mn2+ may be due to an increase in the affinity of binding of Fbg to the glycoprotein IIb-IIIa complex on the membranes of ETP. Manganese(2+) 134-138 fibrinogen beta chain Homo sapiens 195-198 2595667-6 1989 These results indicate that Mn2+ specifically and dose-dependently potentiated Fbg-induced aggregation of ETP and that this effect of Mn2+ may be due to an increase in the affinity of binding of Fbg to the glycoprotein IIb-IIIa complex on the membranes of ETP. etp 106-109 fibrinogen beta chain Homo sapiens 79-82 2595667-6 1989 These results indicate that Mn2+ specifically and dose-dependently potentiated Fbg-induced aggregation of ETP and that this effect of Mn2+ may be due to an increase in the affinity of binding of Fbg to the glycoprotein IIb-IIIa complex on the membranes of ETP. etp 106-109 fibrinogen beta chain Homo sapiens 195-198 2478231-8 1989 High concentrations (0.5 to 1 mmol/L) of synthetic peptide gamma 57.5 405-416 only weakly inhibited ADP-induced platelet aggregation supported by either fibrinogen gamma 50 or gamma 57.5. Adenosine Diphosphate 100-103 fibrinogen beta chain Homo sapiens 153-163 2478231-9 1989 Binding of fibrinogen gamma 50 (IC50 = 780 mumol/L) or gamma 57.5 (IC50 = 650 mumol/L) to ADP-stimulated platelets was weakly inhibited, and MoAb L2B failed to inhibit fibrinogen gamma 57.5 binding. Adenosine Diphosphate 90-93 fibrinogen beta chain Homo sapiens 11-21 2508793-0 1989 Activation of protein kinase C in platelets by epinephrine and A23187: correlation with fibrinogen binding. Epinephrine 47-58 fibrinogen beta chain Homo sapiens 88-98 2508793-0 1989 Activation of protein kinase C in platelets by epinephrine and A23187: correlation with fibrinogen binding. Calcimycin 63-69 fibrinogen beta chain Homo sapiens 88-98 2508793-5 1989 Subaggregating concentrations of A23187 alone released platelet fibrinogen and increased platelet membrane binding of [3H]-phorbol dibutyrate, but these were not enhanced by epinephrine. Calcimycin 33-39 fibrinogen beta chain Homo sapiens 64-74 2508793-7 1989 Thus, epinephrine and A23187 together activate PKC by a mechanism that does not require phospholipase C or enhanced binding of PKC to the plasma membrane; PKC activation in turn is correlated with enhanced platelet fibrinogen binding and aggregation. Epinephrine 6-17 fibrinogen beta chain Homo sapiens 215-225 2508793-7 1989 Thus, epinephrine and A23187 together activate PKC by a mechanism that does not require phospholipase C or enhanced binding of PKC to the plasma membrane; PKC activation in turn is correlated with enhanced platelet fibrinogen binding and aggregation. Calcimycin 22-28 fibrinogen beta chain Homo sapiens 215-225 2622536-1 1989 Fibrinogen level is an independent predisposing factor for coronary heart disease and has a prognostic significance comparable with that of cigarette smoking, serum cholesterol level and hypertension. Cholesterol 165-176 fibrinogen beta chain Homo sapiens 0-10 2556779-8 1989 Ticlopidine, by inhibiting fibrinogen binding to the complex, is a potent antiaggregation agent. Ticlopidine 0-11 fibrinogen beta chain Homo sapiens 27-37 2617471-0 1989 Fibrinogen Baltimore IV: congenital dysfibrinogenemia with a gamma 275 (Arg----Cys) substitution. Arginine 72-75 fibrinogen beta chain Homo sapiens 0-10 2617471-0 1989 Fibrinogen Baltimore IV: congenital dysfibrinogenemia with a gamma 275 (Arg----Cys) substitution. Cysteine 79-82 fibrinogen beta chain Homo sapiens 0-10 2617471-1 1989 The major functional characteristics of fibrinogen Baltimore IV include delayed fibrin monomer polymerization which is not corrected by the addition of calcium, inhibition of normal plasma coagulation upon mixing, and a biphasic polymerization profile in which the abnormal fibrin monomers appear to polymerize at about 2% of the normal rate (Ebert & Bell, Thromb. Adenosine Monophosphate 350-353 fibrinogen beta chain Homo sapiens 40-50 2617471-4 1989 We now report the detection of an abnormal peptide in a comparative peptide map from a cyanogen bromide digest of fibrinogen Baltimore IV. Cyanogen Bromide 87-103 fibrinogen beta chain Homo sapiens 114-124 2605181-5 1989 Elemental analysis indicates a redistribution of Zn(II) from the fibrinogen to the albumin compartment, and the resultant fibrin clots are less turbid. Zinc 49-55 fibrinogen beta chain Homo sapiens 65-75 2629450-8 1989 The present study indicates that low-calorie, low-salt diet decreases plasma fibrinogen levels and improves whole blood filterability in elderly obese women with hypertension. Salts 50-54 fibrinogen beta chain Homo sapiens 77-87 2688760-1 1989 It is clear that the control of plasma fibrinogen levels is complex, involving not only many environmental factors such as alcohol intake, smoking habit, age, obesity and the acute phase response, but also genetic factors as shown by the association of the Bcl I RFLP of the beta-fibrinogen gene with plasma fibrinogen levels. Alcohols 123-130 fibrinogen beta chain Homo sapiens 39-49 2511148-1 1989 Evidence from studies in carcinoma patients who received intravenous glucose or glucose-lipid solutions preoperatively indicates that fibrinogen, alpha-II-macroglobulin, and coeruloplasmin serum levels remain unchanged. Glucose 69-76 fibrinogen beta chain Homo sapiens 134-144 2511148-1 1989 Evidence from studies in carcinoma patients who received intravenous glucose or glucose-lipid solutions preoperatively indicates that fibrinogen, alpha-II-macroglobulin, and coeruloplasmin serum levels remain unchanged. Glucose 80-87 fibrinogen beta chain Homo sapiens 134-144 2477426-8 1989 At 4 h after therapy, fibrinogen decreased 33% for rt-PA plus Iloprost compared with a 52% for rt-PA alone (p = 0.001). rt-pa 51-56 fibrinogen beta chain Homo sapiens 22-32 2477426-8 1989 At 4 h after therapy, fibrinogen decreased 33% for rt-PA plus Iloprost compared with a 52% for rt-PA alone (p = 0.001). Iloprost 62-70 fibrinogen beta chain Homo sapiens 22-32 2477426-9 1989 Fibrinogen degradation products increased 60% more for rt-PA alone than for rt-PA plus Ilprost. rt-pa 55-60 fibrinogen beta chain Homo sapiens 0-10 2477426-9 1989 Fibrinogen degradation products increased 60% more for rt-PA alone than for rt-PA plus Ilprost. rt-pa 76-81 fibrinogen beta chain Homo sapiens 0-10 2794059-4 1989 [15N]Glycine enrichment in both plasma fibronectin and fibrinogen was also quantified. 15n 1-4 fibrinogen beta chain Homo sapiens 55-65 2794059-4 1989 [15N]Glycine enrichment in both plasma fibronectin and fibrinogen was also quantified. Glycine 5-12 fibrinogen beta chain Homo sapiens 55-65 2806479-7 1989 Fibrinogen was a cofactor in the reaction as gel-filtered platelets were unreactive to heparin but addition of fibrinogen restored their reactivity. Heparin 87-94 fibrinogen beta chain Homo sapiens 0-10 2475731-7 1989 In addition to the commercial products, the self-made fibrinogen glues, especially the PEG glue, were also strong enough for otolaryngological use. Polyethylene Glycols 87-90 fibrinogen beta chain Homo sapiens 54-64 2527238-4 1989 Antibodies raised against a synthetic peptide WTVPTA (Trp-Thr-Val-Pro-Thr-Ala) deduced from the cloned rat FN RGDS domain block ADP-mediated platelet aggregation; this block can be overcome by additional fibrinogen. Nectofibrin Hexapeptide (rat) 54-77 fibrinogen beta chain Homo sapiens 204-214 2527238-4 1989 Antibodies raised against a synthetic peptide WTVPTA (Trp-Thr-Val-Pro-Thr-Ala) deduced from the cloned rat FN RGDS domain block ADP-mediated platelet aggregation; this block can be overcome by additional fibrinogen. Adenosine Diphosphate 128-131 fibrinogen beta chain Homo sapiens 204-214 2526667-8 1989 In contrast, dissociation of platelet-bound fibrinogen by chymotrypsin was less affected by time after equilibrium fibrinogen binding, and minimal changes in antifibrinogen antibody recognition and plasmin-induced dissociation of fibrinogen bound to stimulated but glutaraldehyde-fixed platelets were observed. Glutaral 265-279 fibrinogen beta chain Homo sapiens 44-54 2526667-9 1989 The data suggest that ADP-induced fibrinogen binding to fresh platelets is accompanied by progressive rearrangements of fibrinogen on the platelet surface. Adenosine Diphosphate 22-25 fibrinogen beta chain Homo sapiens 34-44 2526667-9 1989 The data suggest that ADP-induced fibrinogen binding to fresh platelets is accompanied by progressive rearrangements of fibrinogen on the platelet surface. Adenosine Diphosphate 22-25 fibrinogen beta chain Homo sapiens 120-130 2765399-0 1989 Association of fibrinogen with human platelets pretreated with chymotrypsin or aggregated with ADP or thrombin: an immunocytochemical study. Adenosine Diphosphate 95-98 fibrinogen beta chain Homo sapiens 15-25 2765399-5 1989 ADP-induced aggregation was associated with pseudopod formation and fibrinogen binding; granule contents were not released and aggregation and fibrinogen binding were reversible. Adenosine Diphosphate 0-3 fibrinogen beta chain Homo sapiens 68-78 2765399-5 1989 ADP-induced aggregation was associated with pseudopod formation and fibrinogen binding; granule contents were not released and aggregation and fibrinogen binding were reversible. Adenosine Diphosphate 0-3 fibrinogen beta chain Homo sapiens 143-153 2765399-7 1989 Fibrinogen-induced aggregation/agglutination of chymotrypsin-treated platelets was similar to ADP-induced aggregation in that fibrinogen binding was required and granule contents were not released; it differed from ADP-induced aggregation in that pseudopod formation did not occur and the aggregates were irreversible. Adenosine Diphosphate 215-218 fibrinogen beta chain Homo sapiens 0-10 2507434-5 1989 Fibrinogen showed a significant positive correlation (r = 0.2766; P less than 0.01) with progesterone, so the rise in fibrinogen in the luteal phase could be a progesterone effect. Progesterone 89-101 fibrinogen beta chain Homo sapiens 0-10 2507434-5 1989 Fibrinogen showed a significant positive correlation (r = 0.2766; P less than 0.01) with progesterone, so the rise in fibrinogen in the luteal phase could be a progesterone effect. Progesterone 89-101 fibrinogen beta chain Homo sapiens 118-128 2507434-5 1989 Fibrinogen showed a significant positive correlation (r = 0.2766; P less than 0.01) with progesterone, so the rise in fibrinogen in the luteal phase could be a progesterone effect. Progesterone 160-172 fibrinogen beta chain Homo sapiens 0-10 2507434-5 1989 Fibrinogen showed a significant positive correlation (r = 0.2766; P less than 0.01) with progesterone, so the rise in fibrinogen in the luteal phase could be a progesterone effect. Progesterone 160-172 fibrinogen beta chain Homo sapiens 118-128 2738072-9 1989 Affinity chromatography of various fibrinogen derivatives on a fibrin-Celite column showed that only part of the bound fragment DD was displaced by arginine, whereas fragments D1 and E1 were completely eluted under the same conditions. Arginine 148-156 fibrinogen beta chain Homo sapiens 35-45 2549051-0 1989 Fibrinogen sialic acid residues are low affinity calcium-binding sites that influence fibrin assembly. N-Acetylneuraminic Acid 11-22 fibrinogen beta chain Homo sapiens 0-10 2549051-0 1989 Fibrinogen sialic acid residues are low affinity calcium-binding sites that influence fibrin assembly. Calcium 49-56 fibrinogen beta chain Homo sapiens 0-10 2549051-1 1989 Calcium ions occupy low (n congruent to 10; Kd congruent to 1 mM) and high (n = 3; Kd congruent to 1 microM) affinity sites on fibrinogen and facilitate fibrin monomer polymerization. Calcium 0-7 fibrinogen beta chain Homo sapiens 127-137 2549051-4 1989 In this study, we show that removal of fibrinogen sialic acid residues results in loss of low affinity Ca2+-binding sites. N-Acetylneuraminic Acid 50-61 fibrinogen beta chain Homo sapiens 39-49 2549051-7 1989 These observations suggest that the high affinity fibrinogen D-domain Ca2+-binding sites may play a role in the tertiary structure of the D-domain, whereas, sialic acid residues are low affinity sites whose occupancy by Ca2+ at physiological calcium concentration facilitates fibrin polymerization. N-Acetylneuraminic Acid 157-168 fibrinogen beta chain Homo sapiens 50-60 2613766-10 1989 Migration over intact FGN was almost totally blocked by 230 microM-Arg-Gly-Asp-Ser (RGDS), a peptide known to interact with integrin-type receptors. Arginine 67-70 fibrinogen beta chain Homo sapiens 22-25 2613766-10 1989 Migration over intact FGN was almost totally blocked by 230 microM-Arg-Gly-Asp-Ser (RGDS), a peptide known to interact with integrin-type receptors. Glycine 71-74 fibrinogen beta chain Homo sapiens 22-25 2613766-10 1989 Migration over intact FGN was almost totally blocked by 230 microM-Arg-Gly-Asp-Ser (RGDS), a peptide known to interact with integrin-type receptors. Aspartic Acid 75-78 fibrinogen beta chain Homo sapiens 22-25 2613766-10 1989 Migration over intact FGN was almost totally blocked by 230 microM-Arg-Gly-Asp-Ser (RGDS), a peptide known to interact with integrin-type receptors. Serine 79-82 fibrinogen beta chain Homo sapiens 22-25 2588959-3 1989 This congenital dysfibrinogenemia with an A alpha arginine (Arg) to histidine (His) substitution was tentatively designated as fibrinogen Sapporo. alpha arginine 44-58 fibrinogen beta chain Homo sapiens 19-29 2588959-3 1989 This congenital dysfibrinogenemia with an A alpha arginine (Arg) to histidine (His) substitution was tentatively designated as fibrinogen Sapporo. Arginine 60-63 fibrinogen beta chain Homo sapiens 19-29 2588960-3 1989 In 29 patients and 7 control subjects, turnover of intravenously injected 125I-labeled fibrinogen was studied. Iodine-125 74-78 fibrinogen beta chain Homo sapiens 87-97 2588960-7 1989 injected 125I-labeled fibrinogen was significantly accelerated, and the catabolic flux(j3x) of fibrinogen calculated according to a two-compartment model was significantly higher in patients than in controls. Iodine-125 9-13 fibrinogen beta chain Homo sapiens 22-32 2588960-8 1989 Significant relationships were observed between T1/2 of 125I-labeled fibrinogen and the following: plasma levels of vWF: Ag both before and after the venous occlusion, PA activities after the occlusion, PA antigen before the occlusion, and the net decrease in PA activities and the net increase in PA antigen as a result of the occlusion. Protactinium 168-170 fibrinogen beta chain Homo sapiens 69-79 2588960-8 1989 Significant relationships were observed between T1/2 of 125I-labeled fibrinogen and the following: plasma levels of vWF: Ag both before and after the venous occlusion, PA activities after the occlusion, PA antigen before the occlusion, and the net decrease in PA activities and the net increase in PA antigen as a result of the occlusion. Protactinium 203-205 fibrinogen beta chain Homo sapiens 69-79 2588960-8 1989 Significant relationships were observed between T1/2 of 125I-labeled fibrinogen and the following: plasma levels of vWF: Ag both before and after the venous occlusion, PA activities after the occlusion, PA antigen before the occlusion, and the net decrease in PA activities and the net increase in PA antigen as a result of the occlusion. Protactinium 203-205 fibrinogen beta chain Homo sapiens 69-79 2588960-8 1989 Significant relationships were observed between T1/2 of 125I-labeled fibrinogen and the following: plasma levels of vWF: Ag both before and after the venous occlusion, PA activities after the occlusion, PA antigen before the occlusion, and the net decrease in PA activities and the net increase in PA antigen as a result of the occlusion. Protactinium 203-205 fibrinogen beta chain Homo sapiens 69-79 2588960-9 1989 Significant relationships were also observed between j3x of fibrinogen and the following: plasma levels of vWF: Ag both before and after the venous occlusion, vWF: RCo after the occlusion, PA activities after the occlusion, PA antigen before the occlusion, and the net decrease in PA activities resulting from the occlusion. Protactinium 189-191 fibrinogen beta chain Homo sapiens 60-70 2588960-9 1989 Significant relationships were also observed between j3x of fibrinogen and the following: plasma levels of vWF: Ag both before and after the venous occlusion, vWF: RCo after the occlusion, PA activities after the occlusion, PA antigen before the occlusion, and the net decrease in PA activities resulting from the occlusion. Protactinium 224-226 fibrinogen beta chain Homo sapiens 60-70 2588960-9 1989 Significant relationships were also observed between j3x of fibrinogen and the following: plasma levels of vWF: Ag both before and after the venous occlusion, vWF: RCo after the occlusion, PA activities after the occlusion, PA antigen before the occlusion, and the net decrease in PA activities resulting from the occlusion. Protactinium 224-226 fibrinogen beta chain Homo sapiens 60-70 2775232-1 1989 Glycoprotein IIb (GPIIb), one of the two molecular components of the inducible receptor for fibrinogen on the platelet surface, is formed from two subunits, GPIIb alpha (114 kDa) and GPIIb beta (22.5 kDa), joined by a single disulphide bond. disulphide 225-235 fibrinogen beta chain Homo sapiens 92-102 2544585-6 1989 Thrombin derivatives (bovine (pyridoxal phosphate)4-thrombin and human thrombin Quick I), which bind fibrinogen with much reduced affinity, are shown to also interact with thrombomodulin with greatly reduced affinity. Phosphates 40-49 fibrinogen beta chain Homo sapiens 101-111 2553127-0 1989 [Adsorption of fibrinogen on silicon oxide with controlled hydrophobic/hydrophilic properties]. Silicon Dioxide 29-42 fibrinogen beta chain Homo sapiens 15-25 2553127-1 1989 The amount of fibrinogen irreversibly adsorbed on silicon dioxide does not exceed 3.6 pmol/cm2 and depends on the protein concentration, solution pH and surface hydrophobic/hydrophilic properties. Silicon Dioxide 50-65 fibrinogen beta chain Homo sapiens 14-24 2765407-0 1989 Heterogeneity of fibrinogen receptor expression on platelets activated in normal plasma with ADP: analysis by flow cytometry. Adenosine Diphosphate 93-96 fibrinogen beta chain Homo sapiens 17-27 2765407-1 1989 Fibrinogen receptor expression of platelets activated in normal plasma by ADP was measured by flow cytometry after labelling bound fibrinogen with fluorescein-conjugated antifibrinogen antibody. Adenosine Diphosphate 74-77 fibrinogen beta chain Homo sapiens 0-10 2765407-1 1989 Fibrinogen receptor expression of platelets activated in normal plasma by ADP was measured by flow cytometry after labelling bound fibrinogen with fluorescein-conjugated antifibrinogen antibody. Fluorescein 147-158 fibrinogen beta chain Homo sapiens 0-10 2765407-1 1989 Fibrinogen receptor expression of platelets activated in normal plasma by ADP was measured by flow cytometry after labelling bound fibrinogen with fluorescein-conjugated antifibrinogen antibody. Fluorescein 147-158 fibrinogen beta chain Homo sapiens 131-141 2765407-2 1989 The platelet response to ADP was heterogeneous both with respect to number of platelets binding fibrinogen and the amount of fibrinogen bound per platelet. Adenosine Diphosphate 25-28 fibrinogen beta chain Homo sapiens 96-106 2765407-2 1989 The platelet response to ADP was heterogeneous both with respect to number of platelets binding fibrinogen and the amount of fibrinogen bound per platelet. Adenosine Diphosphate 25-28 fibrinogen beta chain Homo sapiens 125-135 2765407-3 1989 The proportion of platelets showing positive antifibrinogen antibody binding increased with increasing ADP concentration; however, even at 10(-3) M ADP, usually about one-fifth of the platelets failed to demonstrate bound fibrinogen. Adenosine Diphosphate 103-106 fibrinogen beta chain Homo sapiens 49-59 2765407-5 1989 The relative fluorescence intensity of individual platelets also increased as ADP concentration was increased, indicating that the average number of fibrinogen molecules bound was also related to agonist concentration. Adenosine Diphosphate 78-81 fibrinogen beta chain Homo sapiens 149-159 2765407-7 1989 This study demonstrates that platelet response to ADP in native plasma is heterogeneous in both the proportion of platelets activated and in the number of available fibrinogen receptors per platelet. Adenosine Diphosphate 50-53 fibrinogen beta chain Homo sapiens 165-175 2526132-5 1989 Zn++ (50 microM) was required for binding of 125I-fibrinogen to neutrophils at 4 degrees C and the addition of Ca++ (2 mM) increased the binding twofold. Zinc 0-4 fibrinogen beta chain Homo sapiens 50-60 2526132-14 1989 Fibrinogen binding to ADP-stimulated platelets was increased twofold by Zn++ (50 microM) and was inhibited by HMWK. Adenosine Diphosphate 22-25 fibrinogen beta chain Homo sapiens 0-10 2526132-14 1989 Fibrinogen binding to ADP-stimulated platelets was increased twofold by Zn++ (50 microM) and was inhibited by HMWK. Zinc 72-76 fibrinogen beta chain Homo sapiens 0-10 2746495-0 1989 Aspirin acetylates fibrinogen and enhances fibrinolysis. Aspirin 0-7 fibrinogen beta chain Homo sapiens 19-29 2738154-5 1989 These subfractions also exhibited decreased (12-50% of normal controls, fibrinogen 30-590 nM, n = 5) ADP-induced aggregation support of gel-sieved platelets, a decrease not demonstrable by whole phi SB, by fibrinogen from the homozygous proband, or by enrichment of the latter with normal soluble fibrin. Adenosine Diphosphate 101-104 fibrinogen beta chain Homo sapiens 72-82 2738154-5 1989 These subfractions also exhibited decreased (12-50% of normal controls, fibrinogen 30-590 nM, n = 5) ADP-induced aggregation support of gel-sieved platelets, a decrease not demonstrable by whole phi SB, by fibrinogen from the homozygous proband, or by enrichment of the latter with normal soluble fibrin. Adenosine Diphosphate 101-104 fibrinogen beta chain Homo sapiens 206-216 2508258-5 1989 After 90 min, in plasma samples containing anti-rt-PA-IgG to inhibit in vitro effects, fibrinogen was decreased to 54%, plasminogen to 52%, alpha 2-antiplasmin to 25%, alpha 2-macroglobulin to 90% and antithrombin III to 85% of initial values. Hydrocortisone 48-50 fibrinogen beta chain Homo sapiens 87-97 2545197-1 1989 Binding of ADP to platelets enhances the binding of fibrinogen to Gp IIb-IIIa, the specific platelet receptor for adhesive proteins. Adenosine Diphosphate 11-14 fibrinogen beta chain Homo sapiens 52-62 2545197-2 1989 The linkage between ADP and fibrinogen binding is indirect since ADP does not bind to the same receptor as fibrinogen. Adenosine Diphosphate 20-23 fibrinogen beta chain Homo sapiens 28-38 2545197-2 1989 The linkage between ADP and fibrinogen binding is indirect since ADP does not bind to the same receptor as fibrinogen. Adenosine Diphosphate 65-68 fibrinogen beta chain Homo sapiens 28-38 2545197-3 1989 We have recently proposed that a third component, once affected by ADP binding, induces a conformational transition of the fibrinogen receptor from the low to the high affinity state, which is responsible for platelet aggregation [De Cristofaro, R., Landolfi, R., Castagnola, M., De Candia, E., Di Cera, E., & Wyman, J. Adenosine Diphosphate 67-70 fibrinogen beta chain Homo sapiens 123-133 2545197-3 1989 We have recently proposed that a third component, once affected by ADP binding, induces a conformational transition of the fibrinogen receptor from the low to the high affinity state, which is responsible for platelet aggregation [De Cristofaro, R., Landolfi, R., Castagnola, M., De Candia, E., Di Cera, E., & Wyman, J. Adenosine Monophosphate 309-312 fibrinogen beta chain Homo sapiens 123-133 2545197-10 1989 Inhibition of the antiport by pharmacological agents such as amiloride, or else by decreasing extracellular Na+, results in a marked decrease of fibrinogen binding to platelets. Amiloride 61-70 fibrinogen beta chain Homo sapiens 145-155 2799757-0 1989 Expression of fibrinogen receptors in platelets of migraine patients--correlation with platelet GPIIb content and plasma cholesterol. Cholesterol 121-132 fibrinogen beta chain Homo sapiens 14-24 2799757-3 1989 The receptor capacity for fibrinogen in platelets activated by ADP was significantly higher (p less than 0.01) in migraine patients (52,505 +/- 4,925) than in controls (33,881 +/- 3,965). Adenosine Diphosphate 63-66 fibrinogen beta chain Homo sapiens 26-36 2799757-5 1989 There was a high correlation between the number of fibrinogen receptors exposed by ADP and the total amount of platelet GPIIb both in migraine patients (R = 0.69, p less than 0.01) and controls (R = 0.62 p less than 0.01), as well as plasma cholesterol in the case of migraine patients (R = 0.82, p less than 0.001). Cholesterol 241-252 fibrinogen beta chain Homo sapiens 51-61 2731478-0 1989 [Effect of fenofibrate on fibrinogen concentration and blood viscosity. Fenofibrate 11-22 fibrinogen beta chain Homo sapiens 26-36 2731478-2 1989 The effect of fenofibrate (a clofibrate derivative) on fibrinogen concentration, blood viscosity and myocardial microcirculation was examined in 35 patients with coronary heart disease (n = 27) or hypertension (n = 8). Fenofibrate 14-25 fibrinogen beta chain Homo sapiens 55-65 2508258-5 1989 After 90 min, in plasma samples containing anti-rt-PA-IgG to inhibit in vitro effects, fibrinogen was decreased to 54%, plasminogen to 52%, alpha 2-antiplasmin to 25%, alpha 2-macroglobulin to 90% and antithrombin III to 85% of initial values. Protactinium 51-53 fibrinogen beta chain Homo sapiens 87-97 2773809-3 1989 We have used an immunogold-surface replica technique to study the distribution of GPIIb-IIIa and bound fibrinogen over broad expanses of surface membranes in unstimulated and ADP-activated human platelets. Adenosine Diphosphate 175-178 fibrinogen beta chain Homo sapiens 103-113 2773809-5 1989 To ascertain whether the receptors clustered prior to ligand binding or as a consequence thereof, we studied the surface distribution of GPIIb-IIIa after stimulation with ADP, which causes activation of the fibrinogen receptor function of GPIIb-IIIa without inducing the secretion of fibrinogen. Adenosine Diphosphate 171-174 fibrinogen beta chain Homo sapiens 207-217 2773809-5 1989 To ascertain whether the receptors clustered prior to ligand binding or as a consequence thereof, we studied the surface distribution of GPIIb-IIIa after stimulation with ADP, which causes activation of the fibrinogen receptor function of GPIIb-IIIa without inducing the secretion of fibrinogen. Adenosine Diphosphate 171-174 fibrinogen beta chain Homo sapiens 284-294 2773809-8 1989 Clustering was also induced by the addition of the GPIIb-IIIa binding domains of fibrinogen--namely, the tetrapeptide Arg-Gly-Asp-Ser on the alpha-chain or the gamma-chain decapeptide gamma 402-411. Arginine 118-121 fibrinogen beta chain Homo sapiens 81-91 2773809-8 1989 Clustering was also induced by the addition of the GPIIb-IIIa binding domains of fibrinogen--namely, the tetrapeptide Arg-Gly-Asp-Ser on the alpha-chain or the gamma-chain decapeptide gamma 402-411. Glycine 122-125 fibrinogen beta chain Homo sapiens 81-91 2773809-8 1989 Clustering was also induced by the addition of the GPIIb-IIIa binding domains of fibrinogen--namely, the tetrapeptide Arg-Gly-Asp-Ser on the alpha-chain or the gamma-chain decapeptide gamma 402-411. Aspartic Acid 126-129 fibrinogen beta chain Homo sapiens 81-91 2773809-8 1989 Clustering was also induced by the addition of the GPIIb-IIIa binding domains of fibrinogen--namely, the tetrapeptide Arg-Gly-Asp-Ser on the alpha-chain or the gamma-chain decapeptide gamma 402-411. Serine 130-133 fibrinogen beta chain Homo sapiens 81-91 2738096-6 1989 The results indicate that: (a) both RGDX and gamma-chain peptides inhibit the binding of fibrinogen to platelets and endothelial cells; (b) a marked influence of the residue at the COOH- and NH2-terminal positions of each peptide set can be demonstrated on the two types; and (c) RGDX and gamma peptides have differential effects on platelets and endothelial cells with respect to fine structural requirements. Carbonic Acid 181-185 fibrinogen beta chain Homo sapiens 89-99 2543293-1 1989 5"-p-Fluorosulfonylbenzoyl adenosine (FSBA), a nucleotide analog of ADP, has been shown to inhibit ADP-induced shape change, aggregation and exposure of fibrinogen binding sites concomitant with covalent modification of a single surface membrane polypeptide of Mr 100,000 (aggregin). 5'-(4-fluorosulfonylbenzoyl)adenosine 0-36 fibrinogen beta chain Homo sapiens 153-163 2543293-1 1989 5"-p-Fluorosulfonylbenzoyl adenosine (FSBA), a nucleotide analog of ADP, has been shown to inhibit ADP-induced shape change, aggregation and exposure of fibrinogen binding sites concomitant with covalent modification of a single surface membrane polypeptide of Mr 100,000 (aggregin). 5'-(4-fluorosulfonylbenzoyl)adenosine 38-42 fibrinogen beta chain Homo sapiens 153-163 2543293-1 1989 5"-p-Fluorosulfonylbenzoyl adenosine (FSBA), a nucleotide analog of ADP, has been shown to inhibit ADP-induced shape change, aggregation and exposure of fibrinogen binding sites concomitant with covalent modification of a single surface membrane polypeptide of Mr 100,000 (aggregin). Adenosine Diphosphate 68-71 fibrinogen beta chain Homo sapiens 153-163 2543293-1 1989 5"-p-Fluorosulfonylbenzoyl adenosine (FSBA), a nucleotide analog of ADP, has been shown to inhibit ADP-induced shape change, aggregation and exposure of fibrinogen binding sites concomitant with covalent modification of a single surface membrane polypeptide of Mr 100,000 (aggregin). Adenosine Diphosphate 99-102 fibrinogen beta chain Homo sapiens 153-163 2543293-4 1989 In contrast, incubation of [3H]FSBA-labeled intact platelets with a higher concentration of thrombin (0.2 U/ml) resulted in cleavage of radiolabeled aggregin, aggregation, and exposure of fibrinogen binding sites. Tritium 28-30 fibrinogen beta chain Homo sapiens 188-198 2757189-1 1989 Irradiation of fibrinogen with visible light for 30 s in the presence of 1-1000 microM fluorescein was found to crosslink fibrinogen both inter- and intramolecularly. Fluorescein 87-98 fibrinogen beta chain Homo sapiens 15-25 2767848-8 1989 Clofibrate apparently reduced fibrinogen levels, which might account for its specially good effect in preventing HA in smokers. Clofibrate 0-10 fibrinogen beta chain Homo sapiens 30-40 2757189-1 1989 Irradiation of fibrinogen with visible light for 30 s in the presence of 1-1000 microM fluorescein was found to crosslink fibrinogen both inter- and intramolecularly. Fluorescein 87-98 fibrinogen beta chain Homo sapiens 122-132 2469495-3 1989 TM83 dose-dependently inhibited both thrombin-induced aggregation and fibrinogen binding to activated platelets. tm83 0-4 fibrinogen beta chain Homo sapiens 70-80 2773059-0 1989 [Ultrastructural changes of platelets during ADP- stimulated aggregation (in the presence of fibrinogen)]. Adenosine Diphosphate 45-48 fibrinogen beta chain Homo sapiens 93-103 2496144-0 1989 A gamma methionine-310 to threonine substitution and consequent N-glycosylation at gamma asparagine-308 identified in a congenital dysfibrinogenemia associated with posttraumatic bleeding, fibrinogen Asahi. Nitrogen 64-65 fibrinogen beta chain Homo sapiens 134-144 2496144-0 1989 A gamma methionine-310 to threonine substitution and consequent N-glycosylation at gamma asparagine-308 identified in a congenital dysfibrinogenemia associated with posttraumatic bleeding, fibrinogen Asahi. gamma asparagine 83-99 fibrinogen beta chain Homo sapiens 134-144 2769977-3 1989 Measurement of FITC-labelled fibrinogen antibody against the fibrinogen combined with platelet glycoprotein GP IIb/IIIa complex using flow cytometry showed an apparently increased positive rate 76.2% for the platelet of the patient, compared with that of 31.9% for the control. Fluorescein-5-isothiocyanate 15-19 fibrinogen beta chain Homo sapiens 29-39 2749596-5 1989 The presence of 5 mM CaCl2 masked the effect of MB in both purified and plasma systems and lowered the threshold for MB-induced purified fibrinogen precipitation to 800 micrograms/ml. Calcium Chloride 21-26 fibrinogen beta chain Homo sapiens 137-147 2526391-2 1989 When equimolar amounts of Glu-plg and SK were mixed with fibrinogen or fibrin, Glu-plg was converted faster to plasmin suggesting that Glu-plg molecule in the complex was converted to plasmin. Glutamic Acid 26-29 fibrinogen beta chain Homo sapiens 57-67 2742818-1 1989 We have previously shown that the alpha chain of human fibrinogen interacts directly with ADP-activated human platelets [Hawiger, J., Timmons, S., Kloczewiak, M., Strong, D. D., & Doolittle, R. F. (1982) Proc. Adenosine Diphosphate 90-93 fibrinogen beta chain Homo sapiens 55-65 2742818-1 1989 We have previously shown that the alpha chain of human fibrinogen interacts directly with ADP-activated human platelets [Hawiger, J., Timmons, S., Kloczewiak, M., Strong, D. D., & Doolittle, R. F. (1982) Proc. Adenosine Monophosphate 179-182 fibrinogen beta chain Homo sapiens 55-65 2742818-7 1989 They encompass residues 92-147 and 518-584, which inhibit 125I-fibrinogen binding to ADP-stimulated platelets. Adenosine Diphosphate 85-88 fibrinogen beta chain Homo sapiens 63-73 2742818-10 1989 The synthetic peptide RGDF, corresponding to residues alpha 95-98, inhibited the binding of 125I-fibrinogen to ADP-treated platelets (IC50 = 2 microM). Adenosine Diphosphate 111-114 fibrinogen beta chain Homo sapiens 97-107 2769977-3 1989 Measurement of FITC-labelled fibrinogen antibody against the fibrinogen combined with platelet glycoprotein GP IIb/IIIa complex using flow cytometry showed an apparently increased positive rate 76.2% for the platelet of the patient, compared with that of 31.9% for the control. Fluorescein-5-isothiocyanate 15-19 fibrinogen beta chain Homo sapiens 61-71 2923917-0 1989 The influence of calcium ions on fibrinogen conformation. Calcium 17-24 fibrinogen beta chain Homo sapiens 33-43 2923917-2 1989 The results obtained suggest that fibrinogen is a flexible molecule and its conformation is influenced by the concentration of calcium ions. Calcium 127-134 fibrinogen beta chain Homo sapiens 34-44 2923917-3 1989 These effects are mediated through binding to the low-affinity calcium binding sites of fibrinogen. Calcium 63-70 fibrinogen beta chain Homo sapiens 88-98 2741416-2 1989 The modified LDL (LDL-F) isolated from plasmin digested fibrin by means of gel permeation chromatography on Sepharose 6B, were associated with fibrinogen and fibronectin degradation products. sepharose 6b 108-120 fibrinogen beta chain Homo sapiens 143-153 2539213-4 1989 At 1 n mol/L alpha-thrombin or 25 nmol/L gamma-thrombin, platelet fibrinogen was expressed on the surface of the cells notwithstanding the presence of AP-2, a monoclonal antibody to the glycoprotein (GP) IIb-IIIa complex, or the synthetic peptides Arg-Gly-Asp-Ser and gamma 400-411, all substances that prevented the binding of plasma fibrinogen to platelets. Peptides 239-247 fibrinogen beta chain Homo sapiens 66-76 2539213-4 1989 At 1 n mol/L alpha-thrombin or 25 nmol/L gamma-thrombin, platelet fibrinogen was expressed on the surface of the cells notwithstanding the presence of AP-2, a monoclonal antibody to the glycoprotein (GP) IIb-IIIa complex, or the synthetic peptides Arg-Gly-Asp-Ser and gamma 400-411, all substances that prevented the binding of plasma fibrinogen to platelets. arginyl-glycyl-aspartyl-serine 248-263 fibrinogen beta chain Homo sapiens 66-76 2660319-10 1989 A significant increase of fibrinogen was seen, as was a decrease of clotting time in the combined prothrombin test in patients receiving concomitant OAC. SDZ 33-243 149-152 fibrinogen beta chain Homo sapiens 26-36 2742153-5 1989 However, the elution of large sodium dodecyl sulfate-protein complexes and other elongated macromolecules (fibrinogen, tropomyosin) was systematically retarded while polyethylene glycol and polyethylene glycol detergents eluted earlier than water-soluble, globular protein as a function of R eta. Sodium Dodecyl Sulfate 30-52 fibrinogen beta chain Homo sapiens 107-117 2713997-6 1989 Likewise, the isoelectrofocussing of purified non-reduced patient"s fibrinogen in agarose gel showed an abnormal distribution in its focussed bands, especially in a group which focussed in a pI-interval between 5.20-5.85. Sepharose 82-89 fibrinogen beta chain Homo sapiens 68-78 2742153-5 1989 However, the elution of large sodium dodecyl sulfate-protein complexes and other elongated macromolecules (fibrinogen, tropomyosin) was systematically retarded while polyethylene glycol and polyethylene glycol detergents eluted earlier than water-soluble, globular protein as a function of R eta. Water 241-246 fibrinogen beta chain Homo sapiens 107-117 2492737-5 1989 Fifteen minutes after drug infusion, plasma fibrinogen levels decreased to 89% of preinfusion value in nt-PA alone, to 84% in nt-PA plus heparin, and to less than 5% in nt-PA plus batroxobin. nt-pa 103-108 fibrinogen beta chain Homo sapiens 44-54 2537118-0 1989 Fibrinogen-endothelial cell interaction in vitro: a pathway mediated by an Arg-Gly-Asp recognition specificity. Arginine 75-78 fibrinogen beta chain Homo sapiens 0-10 2537118-0 1989 Fibrinogen-endothelial cell interaction in vitro: a pathway mediated by an Arg-Gly-Asp recognition specificity. Glycine 79-82 fibrinogen beta chain Homo sapiens 0-10 2537118-0 1989 Fibrinogen-endothelial cell interaction in vitro: a pathway mediated by an Arg-Gly-Asp recognition specificity. Aspartic Acid 83-86 fibrinogen beta chain Homo sapiens 0-10 2537118-2 1989 In the present study, we have investigated whether the FG-EC interaction is mediated by an Arg-Gly-Asp (RGD) recognition specificity and whether EC membrane proteins related to platelet GPIIb-IIIa are involved. arginyl-glycyl-aspartic acid 91-102 fibrinogen beta chain Homo sapiens 55-57 2537118-8 1989 A series of synthetic RGD-containing peptides inhibited FG binding to EC and FG-induced EC migration. Peptides 37-45 fibrinogen beta chain Homo sapiens 56-58 2537118-8 1989 A series of synthetic RGD-containing peptides inhibited FG binding to EC and FG-induced EC migration. Peptides 37-45 fibrinogen beta chain Homo sapiens 77-79 2783860-2 1989 Complex gangliosides were observed to inhibit the adhesion of thrombin-activated platelets to substrates of fibronectin, von Willebrand factor, and fibrinogen. Gangliosides 8-20 fibrinogen beta chain Homo sapiens 148-158 2492737-5 1989 Fifteen minutes after drug infusion, plasma fibrinogen levels decreased to 89% of preinfusion value in nt-PA alone, to 84% in nt-PA plus heparin, and to less than 5% in nt-PA plus batroxobin. nt-pa 126-131 fibrinogen beta chain Homo sapiens 44-54 2492737-5 1989 Fifteen minutes after drug infusion, plasma fibrinogen levels decreased to 89% of preinfusion value in nt-PA alone, to 84% in nt-PA plus heparin, and to less than 5% in nt-PA plus batroxobin. Heparin 137-144 fibrinogen beta chain Homo sapiens 44-54 2492737-5 1989 Fifteen minutes after drug infusion, plasma fibrinogen levels decreased to 89% of preinfusion value in nt-PA alone, to 84% in nt-PA plus heparin, and to less than 5% in nt-PA plus batroxobin. nt-pa 126-131 fibrinogen beta chain Homo sapiens 44-54 2914364-1 1989 In this assay we measure the turbidity produced by precipitation of plasma fibrinogen with a reagent composed of ammonium sulfate, EDTA, and guanidine hydrochloride. Ammonium Sulfate 113-129 fibrinogen beta chain Homo sapiens 75-85 2914364-1 1989 In this assay we measure the turbidity produced by precipitation of plasma fibrinogen with a reagent composed of ammonium sulfate, EDTA, and guanidine hydrochloride. Edetic Acid 131-135 fibrinogen beta chain Homo sapiens 75-85 2499459-0 1989 Improved haemorheology associated with a reduction in plasma fibrinogen and LDL in patients being treated by heparin-induced extracorporeal LDL precipitation (HELP). Heparin 109-116 fibrinogen beta chain Homo sapiens 61-71 2914364-1 1989 In this assay we measure the turbidity produced by precipitation of plasma fibrinogen with a reagent composed of ammonium sulfate, EDTA, and guanidine hydrochloride. Guanidine 141-164 fibrinogen beta chain Homo sapiens 75-85 2708407-6 1989 For each of the four surfaces, glass, siliconized glass, collagen-coated glass and polyethylene, the adsorption of fibrinogen as a function of dilution is the same in whole blood as in plasma. Polyethylene 83-95 fibrinogen beta chain Homo sapiens 115-125 2499459-1 1989 Heparin-induced Extracorporeal LDL-Precipitation (HELP) is an effective procedure for the elimination of both plasma LDL and fibrinogen. Heparin 0-7 fibrinogen beta chain Homo sapiens 125-135 2748698-5 1989 The integrity and the characteristic differences in molecular mass of rat and human fibrinogen chains were demonstrated by means of SDS-PAGE. Sodium Dodecyl Sulfate 132-135 fibrinogen beta chain Homo sapiens 84-94 2741653-5 1989 The 5-day-stored platelets stimulated with the combination of ADP and epinephrine scarcely bound fibrinogen, but did bind NNKY1-32. Adenosine Diphosphate 62-65 fibrinogen beta chain Homo sapiens 97-107 2741653-5 1989 The 5-day-stored platelets stimulated with the combination of ADP and epinephrine scarcely bound fibrinogen, but did bind NNKY1-32. Epinephrine 70-81 fibrinogen beta chain Homo sapiens 97-107 2741653-6 1989 On stimulation with collagen and epinephrine, a large amount of fibrinogen bound to the surface membrane of 3- and 5-day-stored platelets, and the binding of NNKY1-32 also increased, reaching the same level seen in stored platelets stimulated with ADP and epinephrine. Epinephrine 33-44 fibrinogen beta chain Homo sapiens 64-74 2741653-6 1989 On stimulation with collagen and epinephrine, a large amount of fibrinogen bound to the surface membrane of 3- and 5-day-stored platelets, and the binding of NNKY1-32 also increased, reaching the same level seen in stored platelets stimulated with ADP and epinephrine. Adenosine Diphosphate 248-251 fibrinogen beta chain Homo sapiens 64-74 2741653-6 1989 On stimulation with collagen and epinephrine, a large amount of fibrinogen bound to the surface membrane of 3- and 5-day-stored platelets, and the binding of NNKY1-32 also increased, reaching the same level seen in stored platelets stimulated with ADP and epinephrine. Epinephrine 256-267 fibrinogen beta chain Homo sapiens 64-74 2909518-1 1989 The binding of fibrinogen to its platelet receptor, the glycoprotein IIb-IIIa complex, is mediated, in part, by an Arg-Gly-Asp (RGD) sequence within the fibrinogen A alpha chain. arginyl-glycyl-aspartic acid 115-126 fibrinogen beta chain Homo sapiens 15-25 2508417-7 1989 In the other parameters tested there were no significant changes except for a slight increase in plasma fibrinogen in cycle 1 in the gestodene group. Gestodene 133-142 fibrinogen beta chain Homo sapiens 104-114 2643421-6 1989 In fibrous and advanced plaques, fibrinogen/fibrin I, fibrin II, and fibrin(ogen) degradation products were detected in areas of loose connective tissue, in thrombus, and around cholesterol crystals. Cholesterol 178-189 fibrinogen beta chain Homo sapiens 33-43 2535942-0 1989 Epinephrine induces platelet fibrinogen receptor expression, fibrinogen binding, and aggregation in whole blood in the absence of other excitatory agonists. Epinephrine 0-11 fibrinogen beta chain Homo sapiens 29-39 2535942-0 1989 Epinephrine induces platelet fibrinogen receptor expression, fibrinogen binding, and aggregation in whole blood in the absence of other excitatory agonists. Epinephrine 0-11 fibrinogen beta chain Homo sapiens 61-71 2535942-13 1989 We conclude that epinephrine itself can induce fibrinogen receptor exposure, fibrinogen binding, and aggregation. Epinephrine 17-28 fibrinogen beta chain Homo sapiens 47-57 2535942-13 1989 We conclude that epinephrine itself can induce fibrinogen receptor exposure, fibrinogen binding, and aggregation. Epinephrine 17-28 fibrinogen beta chain Homo sapiens 77-87 2476159-0 1989 The molecular-mass dependence of dextran sulfate enhancement of inactivation of thrombin and fibrinogen and on factor Xa neutralization by antithrombin III. Dextran Sulfate 33-48 fibrinogen beta chain Homo sapiens 93-103 2476159-4 1989 Their interactions were also confirmed in three-component systems, in which the interactions of DS with thrombin and fibrinogen were measured by the displaced binding by FTC-heparin, and DS-enhanced proteolysis by chymotrypsin, respectively. Dextran Sulfate 96-98 fibrinogen beta chain Homo sapiens 117-127 2476159-4 1989 Their interactions were also confirmed in three-component systems, in which the interactions of DS with thrombin and fibrinogen were measured by the displaced binding by FTC-heparin, and DS-enhanced proteolysis by chymotrypsin, respectively. fluoresceinylthiocarbamyl-heparin 170-181 fibrinogen beta chain Homo sapiens 117-127 2909518-1 1989 The binding of fibrinogen to its platelet receptor, the glycoprotein IIb-IIIa complex, is mediated, in part, by an Arg-Gly-Asp (RGD) sequence within the fibrinogen A alpha chain. arginyl-glycyl-aspartic acid 115-126 fibrinogen beta chain Homo sapiens 153-163 2909518-6 1989 H-CDR3 contained a sequence, Arg-Tyr-Asp (RYD), that, if present in the proper conformation, might behave like the RGD sequence in fibrinogen. arginyl-tyrosyl-aspartic acid 29-40 fibrinogen beta chain Homo sapiens 131-141 2744931-4 1989 Plasma fibrinogen concentrations were elevated in 34 percent of patients; the values did not relate to excess weight and they correlated negatively (P less than 0.04) with increasing serum triglycerides and grades of liver fat content. Triglycerides 189-202 fibrinogen beta chain Homo sapiens 7-17 2668067-2 1989 Pretreatment of some proteins (albumin, immunoglobulin G, elastin and fibrinogen) with hypochlorite or with the MPO-H2O2-Cl- system increased their susceptibility to proteolysis by trypsin, chymotrypsin or elastase. Hydrogen Peroxide 116-120 fibrinogen beta chain Homo sapiens 70-80 2484687-4 1989 SIN-1A acts as an early step of platelet activation by inhibiting calcium influx and phospholipase activity, which leads to inhibition of thromboxane formation and fibrinogen binding. Calcium 66-73 fibrinogen beta chain Homo sapiens 164-174 2641400-6 1989 In a group of 24 patients first dialyzed using dialyzers only once and then after 4 months" dialyzing with dialyzers used at least 6 times and again after 4 months" of further dialyzing using a dialyzer only once, remarkable changes of the concentration of urea, creatinine, hydrogen carbonates, fibrinogen, the hematocrit indicator, the amount of hemoglobulin, the number of hematocytes, blood platelets and the weights of the patients in blood serum were not observed. Urea 257-261 fibrinogen beta chain Homo sapiens 296-306 2738036-4 1989 Upon sodium dodecyl sulfate-polyacrylamide gel electrophoresis under reducing conditions, fibrinogen Nagoya showed the presence of an extra protein band with an apparent molecular weight of 49,500 in addition to the normal three subunit chains. Sodium Dodecyl Sulfate 5-27 fibrinogen beta chain Homo sapiens 90-100 2738036-4 1989 Upon sodium dodecyl sulfate-polyacrylamide gel electrophoresis under reducing conditions, fibrinogen Nagoya showed the presence of an extra protein band with an apparent molecular weight of 49,500 in addition to the normal three subunit chains. polyacrylamide 28-42 fibrinogen beta chain Homo sapiens 90-100 2738036-5 1989 Amino acid sequence analysis of a peptide isolated from a lysyl endopeptidase digest of one of the CNBr fragments derived from fibrinogen Nagoya indicated that Gln-329 in the gamma-chain had been replaced by Arg. Glutamine 160-163 fibrinogen beta chain Homo sapiens 127-137 2738036-5 1989 Amino acid sequence analysis of a peptide isolated from a lysyl endopeptidase digest of one of the CNBr fragments derived from fibrinogen Nagoya indicated that Gln-329 in the gamma-chain had been replaced by Arg. Arginine 208-211 fibrinogen beta chain Homo sapiens 127-137 2709690-3 1989 During treatment with Acyclovir the bleeding situation was controlled by fibrinogen replacement. Acyclovir 22-31 fibrinogen beta chain Homo sapiens 73-83 2616355-2 1989 PFb was determined by means of passive haemagglutination reaction of human group 0, Rh minus blood cells enveloped by fibrinogen cleared chromatographically. 2,3,4,5,6-Pentafluorobenzyl alcohol 0-3 fibrinogen beta chain Homo sapiens 118-128 2616355-3 1989 PFb were directed against fragments D of fibrinogen (immunoblotting method). 2,3,4,5,6-Pentafluorobenzyl alcohol 0-3 fibrinogen beta chain Homo sapiens 41-51 2616355-8 1989 The results of the examination confirm a hypothesis about the importance of antigenic neodeterminants revealing as a result of proteolytic fibrinogen degradation (fragments D) in inducing PFb. 2,3,4,5,6-Pentafluorobenzyl alcohol 188-191 fibrinogen beta chain Homo sapiens 139-149 2654312-4 1989 Pentoxifylline given in patients with vascular disease or in those with high risk of thrombosis (diabetes, arteritis) induces a significant decrease in plasma fibrinogen level. Pentoxifylline 0-14 fibrinogen beta chain Homo sapiens 159-169 2654312-5 1989 Furthermore, in patients with arteritis, the decrease in fibrinogen level after pentoxifylline is correlated with the improvement in the walking distance. Pentoxifylline 80-94 fibrinogen beta chain Homo sapiens 57-67 2654312-6 1989 Several hypotheses may be taken into account to explain the decrease in fibrinogen induced by pentoxifylline. Pentoxifylline 94-108 fibrinogen beta chain Homo sapiens 72-82 2654312-7 1989 The hypothesis based upon a decrease of fibrinogen synthesis seems very fascinating since pentoxifylline, inducing a decrease in Interleukin 1 activity on leukocytes, might be responsible also for a decrease in interleukin 1 activity as fibrinogen stimulating factor. Pentoxifylline 90-104 fibrinogen beta chain Homo sapiens 40-50 2654312-7 1989 The hypothesis based upon a decrease of fibrinogen synthesis seems very fascinating since pentoxifylline, inducing a decrease in Interleukin 1 activity on leukocytes, might be responsible also for a decrease in interleukin 1 activity as fibrinogen stimulating factor. Pentoxifylline 90-104 fibrinogen beta chain Homo sapiens 237-247 2922698-4 1989 Whole blood anticoagulated by heparin, EDTA or sodium citrate, contained dephosphorylating activity against 32P-labeled fibrinogen, although there were significant differences in activity among the three anticoagulants. Heparin 30-37 fibrinogen beta chain Homo sapiens 120-130 2506696-2 1989 Addition of heparin to cryoprecipitate extract at acid pH precipitated fibrinogen and fibronectin. Heparin 12-19 fibrinogen beta chain Homo sapiens 71-81 2718441-2 1989 Inclusion of heparin, miscleron, complamin in the complex treatment was accompanied by a distinct reduction of the concentration of sterol-fibrinogen complexes, normalization of the ratio of polar sterols. Heparin 13-20 fibrinogen beta chain Homo sapiens 139-149 2718441-2 1989 Inclusion of heparin, miscleron, complamin in the complex treatment was accompanied by a distinct reduction of the concentration of sterol-fibrinogen complexes, normalization of the ratio of polar sterols. Xanthinol Niacinate 33-42 fibrinogen beta chain Homo sapiens 139-149 2718441-3 1989 The employment of miscleron and heparin furthered a reduction of the load of sterols on fibrinogen. Heparin 32-39 fibrinogen beta chain Homo sapiens 88-98 2922698-4 1989 Whole blood anticoagulated by heparin, EDTA or sodium citrate, contained dephosphorylating activity against 32P-labeled fibrinogen, although there were significant differences in activity among the three anticoagulants. Edetic Acid 39-43 fibrinogen beta chain Homo sapiens 120-130 2922698-4 1989 Whole blood anticoagulated by heparin, EDTA or sodium citrate, contained dephosphorylating activity against 32P-labeled fibrinogen, although there were significant differences in activity among the three anticoagulants. Sodium Citrate 47-61 fibrinogen beta chain Homo sapiens 120-130 2922698-4 1989 Whole blood anticoagulated by heparin, EDTA or sodium citrate, contained dephosphorylating activity against 32P-labeled fibrinogen, although there were significant differences in activity among the three anticoagulants. Phosphorus-32 108-111 fibrinogen beta chain Homo sapiens 120-130 3196365-4 1988 Fibrinogen, fibronectin, and type IV collagen were identified by immunofluorescence in both MTX-treated patients and controls. Methotrexate 92-95 fibrinogen beta chain Homo sapiens 0-10 3222783-12 1988 2D electrophoresis disclosed substantial deviations in the patterns obtained with DIC-plasma, SK-plasma and with fibrinogen purified by beta-alanine-precipitation from that observed with normal plasma. beta-Alanine 136-148 fibrinogen beta chain Homo sapiens 113-123 2903652-8 1988 It is likely that celiprolol"s effect in reducing fibrinogen levels may minimize the increase in blood viscosity associated with the hypertensive state, whereas its effects on fibrinogen may herald a reduction in hypertensive complications such as thrombosis or retinal "cotton wool exudates." Celiprolol 18-28 fibrinogen beta chain Homo sapiens 50-60 2903654-4 1988 Celiprolol is known to exert a beneficial effect on the atheroprotective components of the risk factors for coronary heart disease, such as cholesterol triglyceride, and fibrinogen. Celiprolol 0-10 fibrinogen beta chain Homo sapiens 170-180 3076782-4 1988 The results showed no change in haemorheological determinants in the placebo-treated group but a significant reduction in whole-blood viscosity, in haematocrit, in fibrinogen and fibrinogen/albumin ratio was observed in the bezafibrate treated patients. Bezafibrate 224-235 fibrinogen beta chain Homo sapiens 164-174 3076782-4 1988 The results showed no change in haemorheological determinants in the placebo-treated group but a significant reduction in whole-blood viscosity, in haematocrit, in fibrinogen and fibrinogen/albumin ratio was observed in the bezafibrate treated patients. Bezafibrate 224-235 fibrinogen beta chain Homo sapiens 179-189 3049127-1 1988 Trigramin, a cysteine-rich, RGD-containing peptide isolated from the venom of the Trimeresurus gramineus snake, inhibited the adhesion of human melanoma cells to fibronectin and fibrinogen. trigramin 0-9 fibrinogen beta chain Homo sapiens 178-188 2466071-3 1988 The restoration of euthyroidism either by antithyroid drug or by radioiodine caused a significant decrease of fibrinogen and B beta 15-42. Iodine-131 65-76 fibrinogen beta chain Homo sapiens 110-120 2467438-0 1988 [Structural properties and lipid-binding characteristics of plasma fibrinogen and gamma-globulins in vitamin D-deficient rickets]. Vitamin D 101-110 fibrinogen beta chain Homo sapiens 67-77 3202191-8 1988 Epinephrine potentiates the action of all types of aggregating agents on aggregation, secretion, intracellular Ca2+ levels, membrane fluidity, fibrinogen binding, or protein phosphorylation. Epinephrine 0-11 fibrinogen beta chain Homo sapiens 143-153 3217916-5 1988 Degraded fibrinogen molecules whose A alpha chains all terminated before A alpha #540-554 were isolated from purified fibrinogen preparations by immunoaffinity chromatography on F-102 Sepharose. Sepharose 184-193 fibrinogen beta chain Homo sapiens 9-19 3217923-0 1988 Isolation of fibrinogen A alpha-chain by affinity chromatography on concanavalin A-sepharose. Sepharose 83-92 fibrinogen beta chain Homo sapiens 13-23 3217923-2 1988 A mixture of the three constituent polypeptide chains of human fibrinogen was applied onto a column of concanavalin A-Sepharose. Sepharose 118-127 fibrinogen beta chain Homo sapiens 63-73 2460346-0 1988 Anti-(Arg-Gly-Asp-Ser) antibody and its interaction with fibronectin, fibrinogen and platelets. Arginine 6-9 fibrinogen beta chain Homo sapiens 70-80 2460346-0 1988 Anti-(Arg-Gly-Asp-Ser) antibody and its interaction with fibronectin, fibrinogen and platelets. Glycine 10-13 fibrinogen beta chain Homo sapiens 70-80 2460346-0 1988 Anti-(Arg-Gly-Asp-Ser) antibody and its interaction with fibronectin, fibrinogen and platelets. Aspartic Acid 14-17 fibrinogen beta chain Homo sapiens 70-80 2460346-0 1988 Anti-(Arg-Gly-Asp-Ser) antibody and its interaction with fibronectin, fibrinogen and platelets. Serine 18-21 fibrinogen beta chain Homo sapiens 70-80 3170575-8 1988 These results suggest that carbohydrate constitutively affects the behavior of deglycosylated fibrinogens by 1) contributing a repulsive force that promotes fibrinogen solubility and limits fibrin assembly and 2) sensitizing fibrin to conditions that influence assembly and clot structure. Carbohydrates 27-39 fibrinogen beta chain Homo sapiens 94-104 3417681-5 1988 A lysine residue to thrombin was essential for its binding to fibrinogen. Lysine 2-8 fibrinogen beta chain Homo sapiens 62-72 3417645-2 1988 The platelet membrane glycoprotein IIb-IIIa complex (GPIIb-IIIa) recognizes peptides containing the amino acid sequence Arg-Gly-Asp, a sequence present at two locations in the alpha chain of fibrinogen. Peptides 76-84 fibrinogen beta chain Homo sapiens 191-201 3417645-2 1988 The platelet membrane glycoprotein IIb-IIIa complex (GPIIb-IIIa) recognizes peptides containing the amino acid sequence Arg-Gly-Asp, a sequence present at two locations in the alpha chain of fibrinogen. Arginine 120-123 fibrinogen beta chain Homo sapiens 191-201 3417645-2 1988 The platelet membrane glycoprotein IIb-IIIa complex (GPIIb-IIIa) recognizes peptides containing the amino acid sequence Arg-Gly-Asp, a sequence present at two locations in the alpha chain of fibrinogen. Glycine 124-127 fibrinogen beta chain Homo sapiens 191-201 3417645-2 1988 The platelet membrane glycoprotein IIb-IIIa complex (GPIIb-IIIa) recognizes peptides containing the amino acid sequence Arg-Gly-Asp, a sequence present at two locations in the alpha chain of fibrinogen. Aspartic Acid 128-131 fibrinogen beta chain Homo sapiens 191-201 3417645-4 1988 We found that the alpha chain tetrapeptide, Arg-Gly-Asp-Ser (RGDS), and the gamma chain peptide, Leu-Gly-Gly-Ala-Lys-Gln-Ala-Gly-Asp-Val (LGGAKQAG-DV), each inhibited fibrinogen binding to ADP-stimulated platelets with Ki values of 15.6 +/- 2.7 and 46.2 +/- 8.2 microM, respectively. Leucine 97-100 fibrinogen beta chain Homo sapiens 167-177 3177369-4 1988 Treatment with epsilon-aminocaproic acid to inhibit fibrinolysis and cryoprecipitate to replenish his deficient circulating fibrinogen interrupted the cycle of his systemic coagulopathy and enabled us to transfuse him to a normal hematocrit. Aminocaproic Acid 15-40 fibrinogen beta chain Homo sapiens 124-134 3053211-3 1988 Fibrinogen mimicked these effects of fibrinopeptide A. P-bromophenacyl bromide (100 microM), mepacrine (10 microM), indomethacin (10 microM) and dazoxiben (10 microM) inhibited human platelet aggregation induced by fibrinopeptide A and fibrinogen. dazoxiben 145-154 fibrinogen beta chain Homo sapiens 0-10 3191112-3 1988 At least two well-defined sequences in fibrinogen, Arg-Gly-Asp sequence of A alpha 95-97 and A alpha 572-574 and gamma 400-411, have been shown to interact with glycoprotein IIb-IIIa. Arginine 51-54 fibrinogen beta chain Homo sapiens 39-49 3191112-3 1988 At least two well-defined sequences in fibrinogen, Arg-Gly-Asp sequence of A alpha 95-97 and A alpha 572-574 and gamma 400-411, have been shown to interact with glycoprotein IIb-IIIa. Glycine 55-58 fibrinogen beta chain Homo sapiens 39-49 3191112-3 1988 At least two well-defined sequences in fibrinogen, Arg-Gly-Asp sequence of A alpha 95-97 and A alpha 572-574 and gamma 400-411, have been shown to interact with glycoprotein IIb-IIIa. Aspartic Acid 59-62 fibrinogen beta chain Homo sapiens 39-49 3191112-9 1988 When fibrinogen is chromatographed on a column of agarose-bound B beta 15-42, a cation-dependent retention of fibrinogen on the peptide column was observed, and fibrinogen was eluted from the column by B beta 15-42 but not by B beta 1-14. Sepharose 50-57 fibrinogen beta chain Homo sapiens 5-15 3191112-9 1988 When fibrinogen is chromatographed on a column of agarose-bound B beta 15-42, a cation-dependent retention of fibrinogen on the peptide column was observed, and fibrinogen was eluted from the column by B beta 15-42 but not by B beta 1-14. Sepharose 50-57 fibrinogen beta chain Homo sapiens 110-120 3191112-9 1988 When fibrinogen is chromatographed on a column of agarose-bound B beta 15-42, a cation-dependent retention of fibrinogen on the peptide column was observed, and fibrinogen was eluted from the column by B beta 15-42 but not by B beta 1-14. Sepharose 50-57 fibrinogen beta chain Homo sapiens 110-120 2847919-7 1988 Reversion to the differentiated phenotype in C2-Rev7 (Rev7), selected by growth in glucose-free media, results in the re-expression of many liver-specific functions including the fibrinogen genes. Glucose 83-90 fibrinogen beta chain Homo sapiens 179-189 3062907-0 1988 [Liver function parameters and fibrinogen in intra-arterial and intravenous PGE1 infusion]. Alprostadil 76-80 fibrinogen beta chain Homo sapiens 31-41 2844695-0 1988 Correlation between expression of blood platelet receptors for fibrinogen and plasma cholesterol in migraine patients. Cholesterol 85-96 fibrinogen beta chain Homo sapiens 63-73 3170691-3 1988 A reversed-phase high-performance liquid chromatographic method was developed to isolate the subunits: fibrinogen was reduced with dithioerythritol and alkylated with iodoacetamide. Dithioerythritol 131-147 fibrinogen beta chain Homo sapiens 103-113 3170691-3 1988 A reversed-phase high-performance liquid chromatographic method was developed to isolate the subunits: fibrinogen was reduced with dithioerythritol and alkylated with iodoacetamide. Iodoacetamide 167-180 fibrinogen beta chain Homo sapiens 103-113 2973150-7 1988 In the presence of fibrinogen, washed platelets were aggregated by SJAMP but formaldehyde-fixed platelets were not. Formaldehyde 77-89 fibrinogen beta chain Homo sapiens 19-29 3401284-0 1988 Effect of short-term treatment with bezafibrate on plasma fibrinogen, fibrinopeptide A, platelet activation and blood filterability in atherosclerotic hyperfibrinogenemic patients. Bezafibrate 36-47 fibrinogen beta chain Homo sapiens 58-68 3401284-1 1988 The effect of bezafibrate (BZF) on plasma fibrinogen levels has been studied in 62 patients with atherosclerotic vasculopathy and hyperfibrinogenemia (643 +/- 15 (SEM) mg/dl). Bezafibrate 27-30 fibrinogen beta chain Homo sapiens 42-52 3401284-2 1988 In a preliminary study, 15-30 days of BZF therapy (400-600 mg/day) normalized fibrinogen values in 16 subjects were compared to 16 controls. Bezafibrate 38-41 fibrinogen beta chain Homo sapiens 78-88 3283247-5 1988 Adsorption of serum albumin or cellulose ether polymers to the microtitre plates followed by incubation with whole blood, showed that adsorbed albumin but not the cellulose ether was exchanged by fibrinogen at the surface. cellulose ether polymers 31-55 fibrinogen beta chain Homo sapiens 196-206 3283247-5 1988 Adsorption of serum albumin or cellulose ether polymers to the microtitre plates followed by incubation with whole blood, showed that adsorbed albumin but not the cellulose ether was exchanged by fibrinogen at the surface. cellulose ether 31-46 fibrinogen beta chain Homo sapiens 196-206 2454192-2 1988 In the presence of 10(-6) M dexamethasone beta-fibrinogen mRNA levels increased 6-fold after addition of recombinant human IL 6 (rhIL 6). Dexamethasone 28-41 fibrinogen beta chain Homo sapiens 42-57 2454192-6 1988 Whereas the induction of beta-fibrinogen mRNA was potentiated by dexamethasone, the synthetic glucocorticoid analog was an absolute requirement for the stimulation of alpha 1-acid glycoprotein mRNA. Dexamethasone 65-78 fibrinogen beta chain Homo sapiens 25-40 2455358-3 1988 A good correlation between precipitable (sulphite) and functional (clotting rate) fibrinogen levels was observed in plasma collected on citrate before therapy (r = 0.76) and in samples collected after 3 hours on either aprotinin (r = 0.87) or PPACK (r = 0.82). Citric Acid 136-143 fibrinogen beta chain Homo sapiens 82-92 2455358-4 1988 Precipitable fibrinogen levels were approximately 10% higher than functional level, in baseline samples collected on citrate alone and approximately 20% higher in 3 hour samples collected on either PPACK or aprotinin. Citric Acid 117-124 fibrinogen beta chain Homo sapiens 13-23 3388301-4 1988 Although no fibrinogen was detected on human platelets either before or after treatment with ADP, fibrinogen was expressed on the surface of rabbit platelets after stimulation with ADP. Adenosine Diphosphate 181-184 fibrinogen beta chain Homo sapiens 98-108 2452608-0 1988 Anti-inflammatory drugs modulate histamine release from mast cells induced by fibrinogen degradation products. Histamine 33-42 fibrinogen beta chain Homo sapiens 78-88 2452608-1 1988 The products resulting from proteolytic degradation of human fibrinogen (FDP) were found to induce the release of histamine from rat peritoneal mast cells. Histamine 114-123 fibrinogen beta chain Homo sapiens 61-71 3232130-0 1988 Long-term effects of ticlopidine on fibrinogen and haemorheology in patients with peripheral arterial disease. Ticlopidine 21-32 fibrinogen beta chain Homo sapiens 36-46 3232130-4 1988 Consistently lower values of fibrinogen, haematocrit and whole blood viscosity at high and low shear rate levels were found in the ticlopidine group; the intergroup differences were statistically significant at most but not all follow-up examinations. Ticlopidine 131-142 fibrinogen beta chain Homo sapiens 29-39 3178847-5 1988 Antibodies to surface-bound Fg were able to induce luminol-dependent chemiluminescence, indicating that Fg binding sites have receptor function. Luminol 51-58 fibrinogen beta chain Homo sapiens 28-30 3178847-5 1988 Antibodies to surface-bound Fg were able to induce luminol-dependent chemiluminescence, indicating that Fg binding sites have receptor function. Luminol 51-58 fibrinogen beta chain Homo sapiens 104-106 2902077-5 1988 Hepatic transglutaminase activity, as well as binding and cross-linking of fibrinogen and fibronectin, were maximally supported by Ca2+, partially supported by Mn2+ and Sr2+, and markedly decreased by Mg2+ and Ba2+. strontium cation 169-173 fibrinogen beta chain Homo sapiens 75-85 3242546-6 1988 In addition, evidence is presented for the first time that plasma fibrinogen possesses (GlcNAc beta 1----4Man beta) residues (bisecting GlcNAc) and O-glycosidically bound carbohydrate units. 2-acetamido-2-deoxy-4-O-(beta-2-acetamid-2-deoxyglucopyranosyl)glucopyranose 88-94 fibrinogen beta chain Homo sapiens 66-76 3242546-6 1988 In addition, evidence is presented for the first time that plasma fibrinogen possesses (GlcNAc beta 1----4Man beta) residues (bisecting GlcNAc) and O-glycosidically bound carbohydrate units. 2-acetamido-2-deoxy-4-O-(beta-2-acetamid-2-deoxyglucopyranosyl)glucopyranose 136-142 fibrinogen beta chain Homo sapiens 66-76 3242546-6 1988 In addition, evidence is presented for the first time that plasma fibrinogen possesses (GlcNAc beta 1----4Man beta) residues (bisecting GlcNAc) and O-glycosidically bound carbohydrate units. Carbohydrates 171-183 fibrinogen beta chain Homo sapiens 66-76 2971042-5 1988 This unique cystine structure at the mutation site has not been reported heretofore in any abnormal protein including fibrinogen. Cystine 12-19 fibrinogen beta chain Homo sapiens 118-128 3417645-4 1988 We found that the alpha chain tetrapeptide, Arg-Gly-Asp-Ser (RGDS), and the gamma chain peptide, Leu-Gly-Gly-Ala-Lys-Gln-Ala-Gly-Asp-Val (LGGAKQAG-DV), each inhibited fibrinogen binding to ADP-stimulated platelets with Ki values of 15.6 +/- 2.7 and 46.2 +/- 8.2 microM, respectively. Alanine 109-112 fibrinogen beta chain Homo sapiens 167-177 3417645-4 1988 We found that the alpha chain tetrapeptide, Arg-Gly-Asp-Ser (RGDS), and the gamma chain peptide, Leu-Gly-Gly-Ala-Lys-Gln-Ala-Gly-Asp-Val (LGGAKQAG-DV), each inhibited fibrinogen binding to ADP-stimulated platelets with Ki values of 15.6 +/- 2.7 and 46.2 +/- 8.2 microM, respectively. Lysine 113-116 fibrinogen beta chain Homo sapiens 167-177 3417645-4 1988 We found that the alpha chain tetrapeptide, Arg-Gly-Asp-Ser (RGDS), and the gamma chain peptide, Leu-Gly-Gly-Ala-Lys-Gln-Ala-Gly-Asp-Val (LGGAKQAG-DV), each inhibited fibrinogen binding to ADP-stimulated platelets with Ki values of 15.6 +/- 2.7 and 46.2 +/- 8.2 microM, respectively. Glutamine 117-120 fibrinogen beta chain Homo sapiens 167-177 3417645-4 1988 We found that the alpha chain tetrapeptide, Arg-Gly-Asp-Ser (RGDS), and the gamma chain peptide, Leu-Gly-Gly-Ala-Lys-Gln-Ala-Gly-Asp-Val (LGGAKQAG-DV), each inhibited fibrinogen binding to ADP-stimulated platelets with Ki values of 15.6 +/- 2.7 and 46.2 +/- 8.2 microM, respectively. alanyl-glycyl-aspartyl-valine 121-136 fibrinogen beta chain Homo sapiens 167-177 2843248-0 1988 The role of fibrinogen A alpha chains in ADP-induced platelet aggregation in the presence of fibrinogen molecules containing gamma" chains. Adenosine Diphosphate 41-44 fibrinogen beta chain Homo sapiens 12-22 2843248-2 1988 In this study, we compared the contribution to adenosine diphosphate (ADP)-induced platelet aggregation of the A alpha chains in Fgn molecules containing predominantly (fraction 1-2) or exclusively (peak 1 Fgn) gammaA chains with that of molecules containing approximately 50% gamma" chains (peak 2 Fgn). Adenosine Diphosphate 47-68 fibrinogen beta chain Homo sapiens 129-132 2843248-2 1988 In this study, we compared the contribution to adenosine diphosphate (ADP)-induced platelet aggregation of the A alpha chains in Fgn molecules containing predominantly (fraction 1-2) or exclusively (peak 1 Fgn) gammaA chains with that of molecules containing approximately 50% gamma" chains (peak 2 Fgn). Adenosine Diphosphate 70-73 fibrinogen beta chain Homo sapiens 129-132 2843248-3 1988 Using washed human platelets, we confirmed that the number of peak 2 Fgn molecules binding to platelets in the presence of ADP was about half the number of peak 1 Fgn molecules (18,962 +/- 2,298 v 44,366 +/- 16,096 molecules per platelet), and that isolated S-carboxymethylated (SCM) gammaA chains supported ADP-induced platelet aggregation nearly as well as peak 1 Fgn. Adenosine Diphosphate 123-126 fibrinogen beta chain Homo sapiens 69-72 2843248-3 1988 Using washed human platelets, we confirmed that the number of peak 2 Fgn molecules binding to platelets in the presence of ADP was about half the number of peak 1 Fgn molecules (18,962 +/- 2,298 v 44,366 +/- 16,096 molecules per platelet), and that isolated S-carboxymethylated (SCM) gammaA chains supported ADP-induced platelet aggregation nearly as well as peak 1 Fgn. Adenosine Diphosphate 308-311 fibrinogen beta chain Homo sapiens 69-72 3136953-12 1988 Fibrinogen levels decreased to 65 +/- 21% of baseline at 90 minutes of rt-PA infusion. rt-pa 71-76 fibrinogen beta chain Homo sapiens 0-10 3136953-13 1988 During the rt-PA maintenance infusion, fibrinogen fell slightly from 63 +/- 26 to 57 +/- 28% (p = 0.18). rt-pa 11-16 fibrinogen beta chain Homo sapiens 39-49 3187957-9 1988 These results indicate that fibrinogen and GPIIb/IIIa are important for shear-induced platelet aggregation and that the induction of fibrinogen receptor on GPIIb/IIIa may partially depend upon thromboxane A2 synthesis in platelets. Thromboxane A2 193-207 fibrinogen beta chain Homo sapiens 133-143 2455569-4 1988 The binding of 125I-fibrinogen to platelets occurred in a PMA2 concentration-dependent manner and was blocked by EDTA or an anti-glycoprotein (GP)IIb-IIIa monoclonal antibody. Edetic Acid 113-117 fibrinogen beta chain Homo sapiens 20-30 2455569-6 1988 The role of secreted ADP and thromboxane in fibrinogen-binding and subsequent platelet aggregation was studied using creatine phosphate/creatine phosphokinase (CP/CPK) and aspirin. Adenosine Diphosphate 21-24 fibrinogen beta chain Homo sapiens 44-54 2455569-6 1988 The role of secreted ADP and thromboxane in fibrinogen-binding and subsequent platelet aggregation was studied using creatine phosphate/creatine phosphokinase (CP/CPK) and aspirin. Thromboxanes 29-40 fibrinogen beta chain Homo sapiens 44-54 2455569-7 1988 CP/CPK or aspirin alone reduced fibrinogen binding to 20% to 30%; however, this binding was sufficient to support full platelet aggregation. Aspirin 10-17 fibrinogen beta chain Homo sapiens 32-42 2455569-8 1988 Combined treatment with CP/CPK and aspirin abolished fibrinogen binding and aggregation. Aspirin 35-42 fibrinogen beta chain Homo sapiens 53-63 2455569-9 1988 These results demonstrate that the binding of IgG molecules to the CD9 antigen exposes fibrinogen receptors through both secreted ADP and thromboxane and that either one of both can expose the receptors to an extent sufficient to aggregate platelets. Adenosine Diphosphate 130-133 fibrinogen beta chain Homo sapiens 87-97 2455569-9 1988 These results demonstrate that the binding of IgG molecules to the CD9 antigen exposes fibrinogen receptors through both secreted ADP and thromboxane and that either one of both can expose the receptors to an extent sufficient to aggregate platelets. Thromboxanes 138-149 fibrinogen beta chain Homo sapiens 87-97 2455207-2 1988 By increasing the ammonium sulfate concentration 100% during fibrinogen precipitation, the bonding power of two glued 1-cm2 pieces of human dura almost doubled. Ammonium Sulfate 18-34 fibrinogen beta chain Homo sapiens 61-71 3166991-3 1988 The previous suggestion that there is a hairpin loop involving residues Gly(12) to Val(15) in the A alpha chain of human fibrinogen is supported by the slow backbone NH exchange rates of Gly(14) and Val(15), by an unusually small NH chemical shift of Val(15), and by strong sequential NOE"s involving this region in F10. Glycine 72-75 fibrinogen beta chain Homo sapiens 121-131 3166991-3 1988 The previous suggestion that there is a hairpin loop involving residues Gly(12) to Val(15) in the A alpha chain of human fibrinogen is supported by the slow backbone NH exchange rates of Gly(14) and Val(15), by an unusually small NH chemical shift of Val(15), and by strong sequential NOE"s involving this region in F10. Valine 83-86 fibrinogen beta chain Homo sapiens 121-131 3166991-3 1988 The previous suggestion that there is a hairpin loop involving residues Gly(12) to Val(15) in the A alpha chain of human fibrinogen is supported by the slow backbone NH exchange rates of Gly(14) and Val(15), by an unusually small NH chemical shift of Val(15), and by strong sequential NOE"s involving this region in F10. Valine 199-202 fibrinogen beta chain Homo sapiens 121-131 3366765-7 1988 Electrophoretic light scattering and the binding of type IV collagen by fibrinogen-Sepharose further establish the interaction between type IV collagen and fibrinogen. Sepharose 83-92 fibrinogen beta chain Homo sapiens 72-82 3366765-7 1988 Electrophoretic light scattering and the binding of type IV collagen by fibrinogen-Sepharose further establish the interaction between type IV collagen and fibrinogen. Sepharose 83-92 fibrinogen beta chain Homo sapiens 156-166 3371358-0 1988 Polymerization and gelation of fibrinogen in D2O. Deuterium Oxide 45-48 fibrinogen beta chain Homo sapiens 31-41 3371358-1 1988 The solution properties of fibrinogen and the thrombin-induced activation and gelation of fibrinogen in 95% D2O at pH 7.4 were compared to those in H2O under similar conditions. Deuterium Oxide 108-111 fibrinogen beta chain Homo sapiens 90-100 3371358-4 1988 From turbidity measurements at 450 nm it is obvious that fibrinogen is soluble in a slightly more narrow range of NaCl concentration and that the fibrin gels have a higher degree of lateral aggregation in D2O than in H2O. Sodium Chloride 114-118 fibrinogen beta chain Homo sapiens 57-67 3371358-4 1988 From turbidity measurements at 450 nm it is obvious that fibrinogen is soluble in a slightly more narrow range of NaCl concentration and that the fibrin gels have a higher degree of lateral aggregation in D2O than in H2O. Deuterium Oxide 205-208 fibrinogen beta chain Homo sapiens 57-67 3371358-4 1988 From turbidity measurements at 450 nm it is obvious that fibrinogen is soluble in a slightly more narrow range of NaCl concentration and that the fibrin gels have a higher degree of lateral aggregation in D2O than in H2O. Water 217-220 fibrinogen beta chain Homo sapiens 57-67 3371358-5 1988 The variation of fibrinogen concentration, thrombin concentration, pH and ionic a strength have a similar dependence on the final gel structure and clotting time in D2O and H2O. Deuterium Oxide 165-168 fibrinogen beta chain Homo sapiens 17-27 3371358-5 1988 The variation of fibrinogen concentration, thrombin concentration, pH and ionic a strength have a similar dependence on the final gel structure and clotting time in D2O and H2O. Water 173-176 fibrinogen beta chain Homo sapiens 17-27 3371358-8 1988 When fibrinogen solutions in 95% D2O were incubated at 20 mM CaCl2, a slow gelation of fibrinogen was observed, which was found to be induced by trace amounts of factor XIII. Deuterium Oxide 33-36 fibrinogen beta chain Homo sapiens 5-15 3371358-8 1988 When fibrinogen solutions in 95% D2O were incubated at 20 mM CaCl2, a slow gelation of fibrinogen was observed, which was found to be induced by trace amounts of factor XIII. Deuterium Oxide 33-36 fibrinogen beta chain Homo sapiens 87-97 3371358-8 1988 When fibrinogen solutions in 95% D2O were incubated at 20 mM CaCl2, a slow gelation of fibrinogen was observed, which was found to be induced by trace amounts of factor XIII. Calcium Chloride 61-66 fibrinogen beta chain Homo sapiens 5-15 3371358-8 1988 When fibrinogen solutions in 95% D2O were incubated at 20 mM CaCl2, a slow gelation of fibrinogen was observed, which was found to be induced by trace amounts of factor XIII. Calcium Chloride 61-66 fibrinogen beta chain Homo sapiens 87-97 3371358-10 1988 The differences in solubility for fibrinogen, kinetics for the enzyme reaction and optical properties for the fibrin gels in D2O and H2O may be explained by differences in electrostatic interactions, hydrogen bonding and hydration of fibrinogen in these two media. Deuterium Oxide 125-128 fibrinogen beta chain Homo sapiens 34-44 3371358-10 1988 The differences in solubility for fibrinogen, kinetics for the enzyme reaction and optical properties for the fibrin gels in D2O and H2O may be explained by differences in electrostatic interactions, hydrogen bonding and hydration of fibrinogen in these two media. Deuterium Oxide 125-128 fibrinogen beta chain Homo sapiens 234-244 3371358-10 1988 The differences in solubility for fibrinogen, kinetics for the enzyme reaction and optical properties for the fibrin gels in D2O and H2O may be explained by differences in electrostatic interactions, hydrogen bonding and hydration of fibrinogen in these two media. Water 133-136 fibrinogen beta chain Homo sapiens 234-244 2467438-2 1988 Content of cholesterol and its esters, developing complexes with fibrinogen, was found to increase simultaneously with a decrease in the phospholipids, containing in the protein fraction, under conditions of the disease. Cholesterol 11-22 fibrinogen beta chain Homo sapiens 65-75 2467438-2 1988 Content of cholesterol and its esters, developing complexes with fibrinogen, was found to increase simultaneously with a decrease in the phospholipids, containing in the protein fraction, under conditions of the disease. Esters 31-37 fibrinogen beta chain Homo sapiens 65-75 2833330-1 1988 Lack of requirement for fibrinogen during adenosine diphosphate-induced responses and enhanced fibrinogen binding in a medium with low calcium levels. Calcium 135-142 fibrinogen beta chain Homo sapiens 95-105 2833330-2 1988 The association of fibrinogen with washed human platelets was examined by immunocytochemistry during aggregation induced by adenosine diphosphate (ADP) and during deaggregation. Adenosine Diphosphate 124-145 fibrinogen beta chain Homo sapiens 19-29 2833330-6 1988 In the medium with 2 mmol/L Ca2+, ADP caused extensive aggregation of normal platelets in the presence of fibrinogen (0.4 mg/mL), and gold particles were evident between the adherent platelets and on the platelet surface; when the platelets deaggregated, gold was no longer present on the surface. Adenosine Diphosphate 34-37 fibrinogen beta chain Homo sapiens 106-116 2833330-7 1988 In a medium without added Ca2+, ADP caused extensive aggregation in the presence of fibrinogen, and large numbers of gold particles were on the platelet surface and even more between adherent platelets. Adenosine Diphosphate 32-35 fibrinogen beta chain Homo sapiens 84-94 2897211-0 1988 Ligation of fibrinogen by factor XIIIa with dithiothreitol: mechanical properties of ligated fibrinogen gels. Dithiothreitol 44-58 fibrinogen beta chain Homo sapiens 12-22 2897211-0 1988 Ligation of fibrinogen by factor XIIIa with dithiothreitol: mechanical properties of ligated fibrinogen gels. Dithiothreitol 44-58 fibrinogen beta chain Homo sapiens 93-103 2965606-8 1988 Furthermore, when normal plasma was first subjected to extensive contact activation by dextran sulfate, during which the HK was extensively degraded to components smaller than the light chain (as assessed by Western blotting), we observed greatly reduced displacement of fibrinogen. Dextran Sulfate 87-102 fibrinogen beta chain Homo sapiens 271-281 3343546-0 1988 Evidence of increased association of fibrinogen with platelets caused by sodium citrate. Sodium Citrate 73-87 fibrinogen beta chain Homo sapiens 37-47 3388294-1 1988 In a medium containing 1 mM extracellular Ca2+ (Ca2+o), the prior addition of 0.5 microM adrenaline to quin 2-loaded human platelets increased both the rate and amplitude of the rise in cytosolic free Ca2+ (Ca2+i) in response to sub-threshold concentrations of thrombin and PAF and these effects were not prevented by blocking either fibrinogen binding and aggregation or cyclo-oxygenase. ca2+o 48-53 fibrinogen beta chain Homo sapiens 334-344 3388294-1 1988 In a medium containing 1 mM extracellular Ca2+ (Ca2+o), the prior addition of 0.5 microM adrenaline to quin 2-loaded human platelets increased both the rate and amplitude of the rise in cytosolic free Ca2+ (Ca2+i) in response to sub-threshold concentrations of thrombin and PAF and these effects were not prevented by blocking either fibrinogen binding and aggregation or cyclo-oxygenase. Epinephrine 89-99 fibrinogen beta chain Homo sapiens 334-344 3388294-1 1988 In a medium containing 1 mM extracellular Ca2+ (Ca2+o), the prior addition of 0.5 microM adrenaline to quin 2-loaded human platelets increased both the rate and amplitude of the rise in cytosolic free Ca2+ (Ca2+i) in response to sub-threshold concentrations of thrombin and PAF and these effects were not prevented by blocking either fibrinogen binding and aggregation or cyclo-oxygenase. Quin2 103-109 fibrinogen beta chain Homo sapiens 334-344 3388301-0 1988 Expression of fibrinogen on the surface of ADP-stimulated platelets: comparison of human and rabbit platelets. Adenosine Diphosphate 43-46 fibrinogen beta chain Homo sapiens 14-24 3388301-1 1988 Fibrinogen is a cofactor in the aggregation of human platelets and must be added to suspensions of washed human platelets for extensive aggregation to occur in response to ADP. Adenosine Diphosphate 172-175 fibrinogen beta chain Homo sapiens 0-10 3281588-1 1988 Previous studies from our laboratories showed that 5"-p-fluorosulfonylbenzoyl adenosine (FSBA) inhibits ADP-induced platelet shape change, aggregation, and exposure of fibrinogen sites while covalently binding to 100-kDa platelet membrane protein (aggregin) on the intact platelet. 5'-(4-fluorosulfonylbenzoyl)adenosine 51-87 fibrinogen beta chain Homo sapiens 168-178 3281588-1 1988 Previous studies from our laboratories showed that 5"-p-fluorosulfonylbenzoyl adenosine (FSBA) inhibits ADP-induced platelet shape change, aggregation, and exposure of fibrinogen sites while covalently binding to 100-kDa platelet membrane protein (aggregin) on the intact platelet. 5'-(4-fluorosulfonylbenzoyl)adenosine 89-93 fibrinogen beta chain Homo sapiens 168-178 3281588-1 1988 Previous studies from our laboratories showed that 5"-p-fluorosulfonylbenzoyl adenosine (FSBA) inhibits ADP-induced platelet shape change, aggregation, and exposure of fibrinogen sites while covalently binding to 100-kDa platelet membrane protein (aggregin) on the intact platelet. Adenosine Diphosphate 104-107 fibrinogen beta chain Homo sapiens 168-178 3135634-5 1988 Results of fibrinogen measurements during infusion of rt-PA were dependent on the method of assay. rt-pa 54-59 fibrinogen beta chain Homo sapiens 11-21 3400084-4 1988 The isolation and separation of fibrinogen material on SDS-PAGE indicates a limited degradation of the parent fibrinogen molecule (340 kD). Sodium Dodecyl Sulfate 55-58 fibrinogen beta chain Homo sapiens 32-42 3378041-4 1988 Chromatography of the isolated chains of fibrinogen E showed that the alpha(Gly17-Lys78) peptide region itself contains a strong binding site for PMSF-thrombin-Sepharose. Phenylmethylsulfonyl Fluoride 146-150 fibrinogen beta chain Homo sapiens 41-51 3378041-4 1988 Chromatography of the isolated chains of fibrinogen E showed that the alpha(Gly17-Lys78) peptide region itself contains a strong binding site for PMSF-thrombin-Sepharose. Sepharose 160-169 fibrinogen beta chain Homo sapiens 41-51 3128351-10 1988 Following addition of 2% sucrose before freeze drying, Factor VIII, total protein and fibrinogen remain virtually stable (less than 15% loss) during heating of the material to 60, 64 or 68 degrees C for 24 to 72 h without changes of protein spectrum following heating. Sucrose 25-32 fibrinogen beta chain Homo sapiens 86-96 3370289-0 1988 Adsorption of fibrinogen on to polystyrene latex coated with the non-ionic surfactant, poloxamer 338. Polystyrenes 31-42 fibrinogen beta chain Homo sapiens 14-24 3370289-1 1988 We have measured the isothermal adsorption of 125I-fibrinogen on to polystyrene latex (PSL), which was prepared without surfactants, and on to PSL with an adsorbed coat of poloxamer 338 (an A-B-A block copolymer where A is poly(oxyethylene) and B is poly(oxypropylene]. Polystyrenes 68-79 fibrinogen beta chain Homo sapiens 51-61 3343546-2 1988 Because citrate has been reported to affect platelet function, we examined the involvement of citrate on the platelet-fibrinogen interactions. Citric Acid 94-101 fibrinogen beta chain Homo sapiens 118-128 3343546-3 1988 More iodine 125-labeled fibrinogen was bound on washed platelets from citrate-anticoagulated blood (CP) than on washed platelets from non-anticoagulated blood (PNB) obtained by the rapid gel filtration of native blood from the same donor. Iodine-125 5-15 fibrinogen beta chain Homo sapiens 24-34 3343546-3 1988 More iodine 125-labeled fibrinogen was bound on washed platelets from citrate-anticoagulated blood (CP) than on washed platelets from non-anticoagulated blood (PNB) obtained by the rapid gel filtration of native blood from the same donor. Citric Acid 70-77 fibrinogen beta chain Homo sapiens 24-34 3343546-5 1988 When blood from one donor was collected into 10 mmol/L and 20 mmol/L citrate, increased binding of 125I-fibrinogen was observed on platelets exposed to 20 mmol/L citrate. Citric Acid 69-76 fibrinogen beta chain Homo sapiens 104-114 3343546-5 1988 When blood from one donor was collected into 10 mmol/L and 20 mmol/L citrate, increased binding of 125I-fibrinogen was observed on platelets exposed to 20 mmol/L citrate. Citric Acid 162-169 fibrinogen beta chain Homo sapiens 104-114 3343546-6 1988 Exposure of PNB to varying citrate concentrations showed enhanced fibrinogen binding with increasing citrate concentrations; differences in the Kd values between non-citrate-treated PNB and citrate-treated PNB were apparent at about 7.5 mmol/L of citrate. 4-nitrobiphenyl 12-15 fibrinogen beta chain Homo sapiens 66-76 3343546-6 1988 Exposure of PNB to varying citrate concentrations showed enhanced fibrinogen binding with increasing citrate concentrations; differences in the Kd values between non-citrate-treated PNB and citrate-treated PNB were apparent at about 7.5 mmol/L of citrate. Citric Acid 27-34 fibrinogen beta chain Homo sapiens 66-76 3343546-6 1988 Exposure of PNB to varying citrate concentrations showed enhanced fibrinogen binding with increasing citrate concentrations; differences in the Kd values between non-citrate-treated PNB and citrate-treated PNB were apparent at about 7.5 mmol/L of citrate. Citric Acid 101-108 fibrinogen beta chain Homo sapiens 66-76 3343546-6 1988 Exposure of PNB to varying citrate concentrations showed enhanced fibrinogen binding with increasing citrate concentrations; differences in the Kd values between non-citrate-treated PNB and citrate-treated PNB were apparent at about 7.5 mmol/L of citrate. Citric Acid 101-108 fibrinogen beta chain Homo sapiens 66-76 3343546-6 1988 Exposure of PNB to varying citrate concentrations showed enhanced fibrinogen binding with increasing citrate concentrations; differences in the Kd values between non-citrate-treated PNB and citrate-treated PNB were apparent at about 7.5 mmol/L of citrate. Citric Acid 101-108 fibrinogen beta chain Homo sapiens 66-76 3343546-6 1988 Exposure of PNB to varying citrate concentrations showed enhanced fibrinogen binding with increasing citrate concentrations; differences in the Kd values between non-citrate-treated PNB and citrate-treated PNB were apparent at about 7.5 mmol/L of citrate. Citric Acid 101-108 fibrinogen beta chain Homo sapiens 66-76 3343546-7 1988 The effects of citrate in increasing the association of fibrinogen with platelets were not caused by variations in the pH; although fibrinogen binding was diminished at low pH of the citrate used, more binding was observed in the presence of citrate than with buffer of the same pH. Citric Acid 15-22 fibrinogen beta chain Homo sapiens 56-66 3343546-7 1988 The effects of citrate in increasing the association of fibrinogen with platelets were not caused by variations in the pH; although fibrinogen binding was diminished at low pH of the citrate used, more binding was observed in the presence of citrate than with buffer of the same pH. Citric Acid 183-190 fibrinogen beta chain Homo sapiens 132-142 3343546-7 1988 The effects of citrate in increasing the association of fibrinogen with platelets were not caused by variations in the pH; although fibrinogen binding was diminished at low pH of the citrate used, more binding was observed in the presence of citrate than with buffer of the same pH. Citric Acid 183-190 fibrinogen beta chain Homo sapiens 132-142 3343546-8 1988 The effects of citrate appear to be on the platelet fibrinogen receptor because nonspecific binding was not affected by the citrate. Citric Acid 15-22 fibrinogen beta chain Homo sapiens 52-62 3343546-9 1988 Inasmuch as no carbon 14-labeled citric acid binding to platelets was observed, citrate may affect the platelet-fibrinogen interactions without binding to the platelets. Citric Acid 80-87 fibrinogen beta chain Homo sapiens 112-122 3343546-10 1988 We conclude that platelet exposure to citrate increases the fibrinogen binding and may lead to the appearance of curved Scatchard plots. Citric Acid 38-45 fibrinogen beta chain Homo sapiens 60-70 3394172-1 1988 Interaction of plasminogen K 1-3 and K 4 fragments containing lysine binding sites with fibrinogen and its fragments has been investigated. Lysine 62-68 fibrinogen beta chain Homo sapiens 88-98 3376054-2 1988 To this purpose a covalent conjugate of vector antibodies to fibrinogen with monoclonal non-inhibiting antibody to urokinase was obtained using cross-linking agent disuccinimidilsuberate. disuccinimidilsuberate 164-186 fibrinogen beta chain Homo sapiens 61-71 3394172-0 1988 [Binding of K 1-3 and K 4 fragments of plasminogen containing lysine-binding sites with fibrinogen and its fragments]. Lysine 62-68 fibrinogen beta chain Homo sapiens 88-98 3394172-5 1988 The results obtained indicate that lysine binding sites located at plasminogen K 1-3 and K 4 fragments correspond to different fibrinogen molecule centres. Lysine 35-41 fibrinogen beta chain Homo sapiens 127-137 3394172-6 1988 The centre complementary to K 4 fragment lysine binding sites could be located at the fibrinogen alpha C domain. Lysine 41-47 fibrinogen beta chain Homo sapiens 86-96 3123091-6 1988 Fibrinogen levels dropped to 48% of baseline after 50 mg and to 36% of baseline after 100 mg rt-PA. rt-pa 93-98 fibrinogen beta chain Homo sapiens 0-10 2449493-3 1988 In contrast to most protein Ag, fibrinogen (Mr 340,000) did not need to be processed by an APC, inasmuch as intact fibrinogen was presented by both pre-fixed and chloroquine-treated macrophages. Chloroquine 162-173 fibrinogen beta chain Homo sapiens 115-125 3337908-2 1988 Purified fibrinogen analyzed on sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) under the reduced condition in the system of Laemmli contained two protein bands in the gamma-chain region (molecular weight, 50,500 as compared with 50,000 for the normal), both with normal crosslinking ability. Sodium Dodecyl Sulfate 32-54 fibrinogen beta chain Homo sapiens 9-19 3337908-2 1988 Purified fibrinogen analyzed on sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) under the reduced condition in the system of Laemmli contained two protein bands in the gamma-chain region (molecular weight, 50,500 as compared with 50,000 for the normal), both with normal crosslinking ability. polyacrylamide 55-69 fibrinogen beta chain Homo sapiens 9-19 3337908-2 1988 Purified fibrinogen analyzed on sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) under the reduced condition in the system of Laemmli contained two protein bands in the gamma-chain region (molecular weight, 50,500 as compared with 50,000 for the normal), both with normal crosslinking ability. Sodium Dodecyl Sulfate 91-94 fibrinogen beta chain Homo sapiens 9-19 2827786-0 1988 Fibrin protofibril and fibrinogen binding to ADP-stimulated platelets: evidence for a common mechanism. Adenosine Diphosphate 45-48 fibrinogen beta chain Homo sapiens 23-33 3365374-1 1988 Kinetic analysis of the release of fibrinopeptides by thrombin and of the calcium uptake upon clotting at high fibrinogen concentrations. Calcium 74-81 fibrinogen beta chain Homo sapiens 111-121 3342530-0 1988 Improved biuret method for determination of fibrinogen. Biuret 9-15 fibrinogen beta chain Homo sapiens 44-54 2461016-3 1988 In general surgery low-dose heparin (LDH) is more effective in preventing isotopic deep-vein thrombosis diagnosed by the radioactive fibrinogen test, but in orthopaedic surgery dextran is superior to heparin. Heparin 28-35 fibrinogen beta chain Homo sapiens 133-143 3258162-4 1988 Fibrinogen-C1q binding was shown to decrease as a function of increasing salt concentrations, indicating either the presence of charged amino acids in the binding sites or an ionic strength induced conformational dependency of the binding. Salts 73-77 fibrinogen beta chain Homo sapiens 0-10 3345288-2 1988 RCA depends on the concentrations of red cells and plasma proteins with a high molecular weight and a large and asymmetrical spatial structure such as fibrinogen, immunoglobulin M and alpha 2-macroglobulin. RCA II 0-3 fibrinogen beta chain Homo sapiens 151-161 2827786-3 1988 Fibrin protofibrils bound to ADP-activated platelets in a time- and concentration-dependent process which was effectively blocked by excess unlabelled fibrinogen, i.e., the binding was specific and appeared to involve a common receptor. Adenosine Diphosphate 29-32 fibrinogen beta chain Homo sapiens 151-161 2827787-1 1988 The molecular basis of platelet-fibrin interactions has been investigated by using synthetic peptides as potential inhibitors of fibrin protofibril and fibrinogen binding to ADP-stimulated platelets, adhesion of fibrin fibers to the platelet surface, and platelet-mediated clot retraction. Adenosine Diphosphate 174-177 fibrinogen beta chain Homo sapiens 152-162 2827787-2 1988 Synthetic peptides of sequence RGDS and HHLGGAKQAGDV, corresponding to regions of the fibrinogen alpha- and gamma-chains previously identified as platelet recognition sites, inhibited the binding of radiolabelled soluble fibrin oligomers to ADP-stimulated platelets with IC50 values of 10 and 40 microM, respectively. Adenosine Diphosphate 241-244 fibrinogen beta chain Homo sapiens 86-96 3334894-1 1988 Fibrinogen is a cofactor in the aggregation of human platelets, and is required for ADP-induced aggregation of washed platelets; however, exogenous fibrinogen is not required for ADP-induced aggregation of washed platelets from rabbits or rats. Adenosine Diphosphate 84-87 fibrinogen beta chain Homo sapiens 0-10 3334894-2 1988 Because with human platelets the cell adhesion peptide, Arg-Gly-Asp-Ser (RGDS), inhibits aggregation and the binding of 125I-fibrinogen to ADP-stimulated platelets, its effects on rabbit and rat platelets were studied to investigate the differences in the fibrinogen requirements of platelets from the three species. arginyl-glycyl-aspartyl-serine 56-71 fibrinogen beta chain Homo sapiens 125-135 3334894-2 1988 Because with human platelets the cell adhesion peptide, Arg-Gly-Asp-Ser (RGDS), inhibits aggregation and the binding of 125I-fibrinogen to ADP-stimulated platelets, its effects on rabbit and rat platelets were studied to investigate the differences in the fibrinogen requirements of platelets from the three species. Adenosine Diphosphate 139-142 fibrinogen beta chain Homo sapiens 125-135 3334894-4 1988 RGDS inhibited the binding of 125I-fibrinogen to ADP-stimulated human platelets by 80% to 90%, but by only 15% to 27% in the case of rabbit or rat platelets. Adenosine Diphosphate 49-52 fibrinogen beta chain Homo sapiens 35-45 3345288-8 1988 Multiple regression analysis showed that the increase in RCA could be mainly attributed to the raised fibrinogen concentration. RCA II 57-60 fibrinogen beta chain Homo sapiens 102-112 3391213-0 1988 Positive imaging of venous thrombi and thromboemboli with Ga-67 DFO-DAS-fibrinogen. Gallium-67 58-63 fibrinogen beta chain Homo sapiens 72-82 3391213-0 1988 Positive imaging of venous thrombi and thromboemboli with Ga-67 DFO-DAS-fibrinogen. Deferoxamine 64-67 fibrinogen beta chain Homo sapiens 72-82 3391213-1 1988 A newly developed thrombus imaging agent, 67Ga-DFO-DAS-fibrinogen (67Ga-fibrinogen), was used for 22 studies in 20 cases of suspected deep venous thrombosis. Deferoxamine 47-50 fibrinogen beta chain Homo sapiens 55-65 3391213-5 1988 67Ga-fibrinogen can be made available simply by adding 67Ga solution to a vial containing fibrinogen-DAS-DFO conjugate. Deferoxamine 105-108 fibrinogen beta chain Homo sapiens 5-15 3224634-4 1988 A method using ethanol precipitation is described for preparing a concentrated fibrinogen solution from plasma separated from small amounts of blood. Ethanol 15-22 fibrinogen beta chain Homo sapiens 79-89 3391213-5 1988 67Ga-fibrinogen can be made available simply by adding 67Ga solution to a vial containing fibrinogen-DAS-DFO conjugate. Deferoxamine 105-108 fibrinogen beta chain Homo sapiens 90-100 3224634-6 1988 The recovery is compared with the recovery obtained by separating the fibrinogen with ammonium sulfate precipitation and with cryoprecipitation. Ammonium Sulfate 86-102 fibrinogen beta chain Homo sapiens 70-80 2466737-6 1988 The vitronectin receptor is involved in the adhesion of endothelial cells to Arg-Gly-Asp-containing immobilized proteins such as vitronectin, fibrinogen, and von Willebrand factor. Arginine 77-80 fibrinogen beta chain Homo sapiens 142-152 2466737-6 1988 The vitronectin receptor is involved in the adhesion of endothelial cells to Arg-Gly-Asp-containing immobilized proteins such as vitronectin, fibrinogen, and von Willebrand factor. Glycine 81-84 fibrinogen beta chain Homo sapiens 142-152 3127307-1 1988 The activation of Glu1-plasminogen (Glu-Pg) by streptokinase (SK), urokinase (UK) and tissue plasminogen activator (tPA) is under rigorous control by molecules such as epsilon-aminocaproic acid (EACA), fibrinogen (Fg), fibrin (Fn) and, as we have recently discovered, anions. Glutamic Acid 18-21 fibrinogen beta chain Homo sapiens 202-212 3127307-1 1988 The activation of Glu1-plasminogen (Glu-Pg) by streptokinase (SK), urokinase (UK) and tissue plasminogen activator (tPA) is under rigorous control by molecules such as epsilon-aminocaproic acid (EACA), fibrinogen (Fg), fibrin (Fn) and, as we have recently discovered, anions. Glutamic Acid 18-21 fibrinogen beta chain Homo sapiens 214-216 3053360-1 1988 It has been found that cationic protein breakdown product--3H-L-arginine labelled peptide fraction--interacts with fibrinogen in the presence of thrombin. Tritium 59-61 fibrinogen beta chain Homo sapiens 115-125 2466737-6 1988 The vitronectin receptor is involved in the adhesion of endothelial cells to Arg-Gly-Asp-containing immobilized proteins such as vitronectin, fibrinogen, and von Willebrand factor. Aspartic Acid 85-88 fibrinogen beta chain Homo sapiens 142-152 3053360-1 1988 It has been found that cationic protein breakdown product--3H-L-arginine labelled peptide fraction--interacts with fibrinogen in the presence of thrombin. Arginine 62-72 fibrinogen beta chain Homo sapiens 115-125 3127307-1 1988 The activation of Glu1-plasminogen (Glu-Pg) by streptokinase (SK), urokinase (UK) and tissue plasminogen activator (tPA) is under rigorous control by molecules such as epsilon-aminocaproic acid (EACA), fibrinogen (Fg), fibrin (Fn) and, as we have recently discovered, anions. Aminocaproic Acid 168-193 fibrinogen beta chain Homo sapiens 202-212 3127307-1 1988 The activation of Glu1-plasminogen (Glu-Pg) by streptokinase (SK), urokinase (UK) and tissue plasminogen activator (tPA) is under rigorous control by molecules such as epsilon-aminocaproic acid (EACA), fibrinogen (Fg), fibrin (Fn) and, as we have recently discovered, anions. Aminocaproic Acid 168-193 fibrinogen beta chain Homo sapiens 214-216 2840370-1 1988 We describe in the present paper the results of the influence of normal and low-molecular-weight heparin on the interaction of human fibrinogen and thrombocytes in human whole blood cotting ex vivo. Heparin 97-104 fibrinogen beta chain Homo sapiens 133-143 3127307-3 1988 In the case of activation by SK, a species of activator complex, composed of Glu-Pg and SK, can be identified that is inhibited by anions, such as Cl-, and stimulated by Fg and Fn. glu-pg 77-83 fibrinogen beta chain Homo sapiens 170-172 2840370-3 1988 The data show that low-molecular-weight heparin inhibits plasma thrombin generation in vivo for longer than normal heparin and it affects the fibrinogen platelet binding less. Heparin 40-47 fibrinogen beta chain Homo sapiens 142-152 3410360-5 1988 Effectiveness of the enhancement of the hydrolysis of S-2251 was in the order of fibrin greater than fibrinogen greater than E greater than D. It could be concluded that a complex of SK, Lys-PLG and potentiating agent is a better enzyme, thus activator, than a complex of SK and Lys-PLG. valyl-leucyl-lysine 4-nitroanilide 54-60 fibrinogen beta chain Homo sapiens 101-111 3439801-0 1987 Subinhibitory concentrations of tetracycline alter fibrinogen binding by Bacteroides intermedius. Tetracycline 32-44 fibrinogen beta chain Homo sapiens 51-61 3338818-2 1988 By contrast, inclusion of the tetrapeptide fibrinogen antagonist, Arg-Gly-Asp-Ser(RGDS), inhibited both intermediate and near-maximal, but not threshold, levels of platelet activation stimulated by AggCRP. arginyl-glycyl-aspartyl-serine 66-81 fibrinogen beta chain Homo sapiens 43-53 2826623-3 1988 Fibrinogen binding to human, gel-filtered platelets was assessed by using intact fibrinogen and a plasmic fibrinogen degradation product (8D-50) lacking intact alpha chains and resembling an intermediate fragment X. Irreversibly bound fibrinogen was defined as fibrinogen that remained associated with thrombin-stimulated platelets in the presence of 10 mmol/L ethylenediaminetetraacetic acid (EDTA) or excess unlabeled fibrinogen. Edetic Acid 361-392 fibrinogen beta chain Homo sapiens 0-10 2826623-3 1988 Fibrinogen binding to human, gel-filtered platelets was assessed by using intact fibrinogen and a plasmic fibrinogen degradation product (8D-50) lacking intact alpha chains and resembling an intermediate fragment X. Irreversibly bound fibrinogen was defined as fibrinogen that remained associated with thrombin-stimulated platelets in the presence of 10 mmol/L ethylenediaminetetraacetic acid (EDTA) or excess unlabeled fibrinogen. Edetic Acid 394-398 fibrinogen beta chain Homo sapiens 0-10 3126348-7 1988 At the end of the rt-PA infusion the circulating fibrinogen level was 61 +/- 35% of the starting value, as measured by a coagulation-rate assay, and 69 +/- 25% as measured by sodium sulphite precipitation. rt-pa 18-23 fibrinogen beta chain Homo sapiens 49-59 3126348-9 1988 In the rt-PA group only 4.5% of the fibrinogen was measured as incoagulable fibrinogen degradation products, compared with 30% in the streptokinase group. rt-pa 7-12 fibrinogen beta chain Homo sapiens 36-46 3126348-9 1988 In the rt-PA group only 4.5% of the fibrinogen was measured as incoagulable fibrinogen degradation products, compared with 30% in the streptokinase group. rt-pa 7-12 fibrinogen beta chain Homo sapiens 76-86 3126349-4 1988 In the rt-PA group the circulating fibrinogen level at the end of the catheterisation was 52 +/- 29% (mean +/- SD) of the starting value. rt-pa 7-12 fibrinogen beta chain Homo sapiens 35-45 3216814-3 1988 In addition, the effect of galactose and calcium ions on the PC activity of these strains in experiments employing human fibrinogen permitted the recognition of these groups of S. aureus strains. Galactose 27-36 fibrinogen beta chain Homo sapiens 121-131 3216814-3 1988 In addition, the effect of galactose and calcium ions on the PC activity of these strains in experiments employing human fibrinogen permitted the recognition of these groups of S. aureus strains. Calcium 41-48 fibrinogen beta chain Homo sapiens 121-131 2447074-0 1987 Biosynthetic and functional properties of an Arg-Gly-Asp-directed receptor involved in human melanoma cell attachment to vitronectin, fibrinogen, and von Willebrand factor. Arginine 45-48 fibrinogen beta chain Homo sapiens 134-144 2447074-6 1987 In addition, a monoclonal antibody, LM609 generated to a functional site on the intact receptor, is capable of preventing M21 cell attachment to vitronectin, von Willebrand factor, fibrinogen, and the Arg-Gly-Asp peptide but not to fibronectin. lm609 36-41 fibrinogen beta chain Homo sapiens 181-191 3124940-5 1987 Following deflazacort treatment, significant rises compared with initial values were seen in erythrocyte sedimentation rate (ESR), plasma fibrinogen, serum alkaline phosphatase, and general pain and tenderness. deflazacort 10-21 fibrinogen beta chain Homo sapiens 138-148 3124940-8 1987 Again, significant rises were seen in ESR, plasma fibrinogen, and serum alkaline phosphatase following the lowest dose of deflazacort, whereas no changes were seen following the higher doses of deflazacort or prednisone. deflazacort 122-133 fibrinogen beta chain Homo sapiens 50-60 2855633-5 1988 Several approaches were used to show that human fibrinogen specifically binds to hyaluronic acid. Hyaluronic Acid 81-96 fibrinogen beta chain Homo sapiens 48-58 3073204-5 1988 Quantitative analysis of the binding carried out with 125I-labelled human fibrinogen on 33 species belonging to different groups (opportunistic fungi, strictly saprophytic or phytopathogenic fungi and dermatophytes or related species) clearly demonstrated that among all the fungi tested, only the pathogenic aspergilli significantly bound fibrinogen. Iodine-125 54-58 fibrinogen beta chain Homo sapiens 74-84 3439801-6 1987 We examined the effect of growth in subinhibitory levels (sub-MICs) of tetracycline on fibrinogen binding by these bacteria and found concentration-dependent inhibition of fibrinogen binding by bacteria grown in the presence of tetracycline over the range of tetracycline concentrations from 1/64 to 1/8 the MIC. Tetracycline 71-83 fibrinogen beta chain Homo sapiens 87-97 3439801-6 1987 We examined the effect of growth in subinhibitory levels (sub-MICs) of tetracycline on fibrinogen binding by these bacteria and found concentration-dependent inhibition of fibrinogen binding by bacteria grown in the presence of tetracycline over the range of tetracycline concentrations from 1/64 to 1/8 the MIC. Tetracycline 71-83 fibrinogen beta chain Homo sapiens 172-182 3439801-6 1987 We examined the effect of growth in subinhibitory levels (sub-MICs) of tetracycline on fibrinogen binding by these bacteria and found concentration-dependent inhibition of fibrinogen binding by bacteria grown in the presence of tetracycline over the range of tetracycline concentrations from 1/64 to 1/8 the MIC. Tetracycline 228-240 fibrinogen beta chain Homo sapiens 87-97 3439801-6 1987 We examined the effect of growth in subinhibitory levels (sub-MICs) of tetracycline on fibrinogen binding by these bacteria and found concentration-dependent inhibition of fibrinogen binding by bacteria grown in the presence of tetracycline over the range of tetracycline concentrations from 1/64 to 1/8 the MIC. Tetracycline 228-240 fibrinogen beta chain Homo sapiens 172-182 3439801-6 1987 We examined the effect of growth in subinhibitory levels (sub-MICs) of tetracycline on fibrinogen binding by these bacteria and found concentration-dependent inhibition of fibrinogen binding by bacteria grown in the presence of tetracycline over the range of tetracycline concentrations from 1/64 to 1/8 the MIC. Tetracycline 228-240 fibrinogen beta chain Homo sapiens 87-97 3439801-6 1987 We examined the effect of growth in subinhibitory levels (sub-MICs) of tetracycline on fibrinogen binding by these bacteria and found concentration-dependent inhibition of fibrinogen binding by bacteria grown in the presence of tetracycline over the range of tetracycline concentrations from 1/64 to 1/8 the MIC. Tetracycline 228-240 fibrinogen beta chain Homo sapiens 172-182 3439801-7 1987 Analysis of the binding data suggests that bacteria grown in the presence of sub-MICs of tetracycline bind fewer fibrinogen molecules per cell than do bacteria grown in the absence of the drug. Tetracycline 89-101 fibrinogen beta chain Homo sapiens 113-123 3439801-8 1987 If fibrinogen-mediated adherence is important in the establishment B. intermedius in periodontal lesions and lesions of acute necrotizing ulcerative gingivitis, then tetracycline may be effective in disrupting establishment of these organisms at concentrations well below those required to achieve a bacteriostatic effect. Tetracycline 166-178 fibrinogen beta chain Homo sapiens 3-13 2822169-5 1987 Thus, in the plasma environment, in the presence of fibrinogen, vWF becomes associated with the platelet surface subsequent to stimulation with ADP or ristocetin. Adenosine Diphosphate 144-147 fibrinogen beta chain Homo sapiens 52-62 3448322-0 1987 [Evaluation of in vivo stability of Ga-67 labeled human fibrinogen; analysis of plasma radioactivity using rats]. Gallium 36-38 fibrinogen beta chain Homo sapiens 56-66 3667609-6 1987 Treatment of platelets with aspirin, incubation in the presence of creatine phosphate/creatine phosphokinase, or omission of Ca2+ and fibrinogen do not affect toxin-mediated phospholipase C activation. Aspirin 28-35 fibrinogen beta chain Homo sapiens 67-144 2822171-8 1987 Ristocetin-induced binding of vWf was inhibited by 6D1, and ADP-induced binding of fibrinogen was inhibited by LJ-CP8. Adenosine Diphosphate 60-63 fibrinogen beta chain Homo sapiens 83-93 2822169-5 1987 Thus, in the plasma environment, in the presence of fibrinogen, vWF becomes associated with the platelet surface subsequent to stimulation with ADP or ristocetin. Ristocetin 151-161 fibrinogen beta chain Homo sapiens 52-62 2822171-8 1987 Ristocetin-induced binding of vWf was inhibited by 6D1, and ADP-induced binding of fibrinogen was inhibited by LJ-CP8. lj-cp8 111-117 fibrinogen beta chain Homo sapiens 83-93 2822171-3 1987 We have developed an indirect, flow cytometry assay that uses fluorescein-labeled antibodies to detect vWf and fibrinogen on platelets. Fluorescein 62-73 fibrinogen beta chain Homo sapiens 111-121 3124289-2 1987 As observed for many proteins, glucose has been shown to bind non enzymatically to fibrinogen and to fibrin. Glucose 31-38 fibrinogen beta chain Homo sapiens 83-93 3124289-3 1987 The in vitro degree of glycosylation depends upon the concentration of glucose added to fibrinogen and also on the incubation period. Glucose 71-78 fibrinogen beta chain Homo sapiens 88-98 3433274-1 1987 Increased serum fibrinogen degradation product (FDP) in liver cirrhosis and hepatic carcinoma as measured by latex agglutination was analyzed by means of SDS-polyacrylamide gel electrophoresis followed by immunoblotting with anti-fibrinogen antibody. Sodium Dodecyl Sulfate 154-157 fibrinogen beta chain Homo sapiens 16-26 3433274-1 1987 Increased serum fibrinogen degradation product (FDP) in liver cirrhosis and hepatic carcinoma as measured by latex agglutination was analyzed by means of SDS-polyacrylamide gel electrophoresis followed by immunoblotting with anti-fibrinogen antibody. polyacrylamide 158-172 fibrinogen beta chain Homo sapiens 16-26 2448890-4 1987 D-Phe-Pro-Arg-CH2Cl (PPACK) enabled correct assays of fibrinogen and fibrinolytic parameters but interfered with coagulometric assays dependent on endogenous thrombin generation. phenylalanyl-prolyl-arginine methyl chloride 0-19 fibrinogen beta chain Homo sapiens 54-64 3433274-4 1987 By using the SDS-gel electrophoresis after disulfide bond reduction, seven serum samples from these 14 patients, who were shown to have no plasmic digest in serum, were found to contain unclottable fibrinogen retained in sera, while the remaining seven samples were revealed to have fibrin monomer in their sera. Sodium Dodecyl Sulfate 13-16 fibrinogen beta chain Homo sapiens 198-208 3433389-3 1987 At the same time the content of phospholipids which form complexes wit fibrinogen gets two times lower. Phospholipids 32-45 fibrinogen beta chain Homo sapiens 71-81 3122725-0 1987 The interaction of streptokinase.plasminogen activator complex, tissue-type plasminogen activator, urokinase and their acylated derivatives with fibrin and cyanogen bromide digest of fibrinogen. Cyanogen Bromide 156-172 fibrinogen beta chain Homo sapiens 183-193 3314587-2 1987 Fibrinogen is sensitive both to proteolysis by contaminants which may constitute as little as 0.2% of the enzyme protein and to denaturation by 1,10-o-phenanthroline, the only substance known to inhibit the proteolysis. 1,10-phenanthroline 144-165 fibrinogen beta chain Homo sapiens 0-10 3314587-7 1987 Using this "protease-free" enzyme at up to a 1:20 molar ratio, fibrinogen that is completely deglycosylated and native has been generated in order to determine the role of the carbohydrate moieties in its function. Carbohydrates 176-188 fibrinogen beta chain Homo sapiens 63-73 2961366-7 1987 Human fibrinogen cross-linked with glutaraldehyde usually reached a 250 times higher reactivity toward the staphylococcal clumping receptor, depending on the condition of the cross-linking reaction. Glutaral 35-49 fibrinogen beta chain Homo sapiens 6-16 3427134-2 1987 The optimal conditions for this binding were elaborated, and the quantitative parameters of Lys-plasminogen binding to fibrinogen-Sepharose were determined. Sepharose 130-139 fibrinogen beta chain Homo sapiens 119-129 3427134-3 1987 It was found that the interaction of Lys-plasminogen with fibrinogen- and fibrin-Sepharose is provided for by the lysine-binding sites of the proenzyme molecule. Lysine 114-120 fibrinogen beta chain Homo sapiens 58-68 3427134-4 1987 After partial hydrolysis of fibrinogen by plasmin, the amount of adsorbed plasminogen increases and the type of binding changes; part of the proenzyme molecules bind in the presence of 0.003 M 6-aminohexanoic acid, i.e., when lysine-binding sites appear to be blocked. Aminocaproic Acid 193-213 fibrinogen beta chain Homo sapiens 28-38 3427134-4 1987 After partial hydrolysis of fibrinogen by plasmin, the amount of adsorbed plasminogen increases and the type of binding changes; part of the proenzyme molecules bind in the presence of 0.003 M 6-aminohexanoic acid, i.e., when lysine-binding sites appear to be blocked. Lysine 226-232 fibrinogen beta chain Homo sapiens 28-38 3427134-8 1987 These sites are complementary for both lysine-and arginine-binding sites of the plasminogen molecule and are localized in the peripheral domains of the fibrinogen molecule. Lysine 39-45 fibrinogen beta chain Homo sapiens 152-162 3427134-8 1987 These sites are complementary for both lysine-and arginine-binding sites of the plasminogen molecule and are localized in the peripheral domains of the fibrinogen molecule. Arginine 50-58 fibrinogen beta chain Homo sapiens 152-162 2447894-1 1987 A specific antibody population against human fibrinogen was isolated from a rabbit antiserum by affinity chromatography on fibrinogen-bound Sepharose gel. Sepharose 140-149 fibrinogen beta chain Homo sapiens 45-55 2443781-2 1987 Autologous fibrinogen, derived by polyethylene glycol precipitation from the blood of an individual patient would avoid this risk, and has been shown to be relatively safe to the ear in animal studies. Polyethylene Glycols 34-53 fibrinogen beta chain Homo sapiens 11-21 2443781-5 1987 When 10% polyethylene glycol was used to precipitate the fibrinogen, the concentrate contained, on the average, 31.8 mg of fibrinogen/ml. Polyethylene Glycols 9-28 fibrinogen beta chain Homo sapiens 57-67 2443781-5 1987 When 10% polyethylene glycol was used to precipitate the fibrinogen, the concentrate contained, on the average, 31.8 mg of fibrinogen/ml. Polyethylene Glycols 9-28 fibrinogen beta chain Homo sapiens 123-133 2443781-7 1987 Increasing the polyethylene glycol concentration in the precipitation process to as high as 15% resulted in an increased yield as high as 91%, but the protein in the final product was only 42.5% fibrinogen. Polyethylene Glycols 15-34 fibrinogen beta chain Homo sapiens 195-205 2443781-8 1987 Polyacrylamide gel electrophoresis confirmed that the predominant protein in the 10% polyethylene glycol precipitate was fibrinogen. polyacrylamide 0-14 fibrinogen beta chain Homo sapiens 121-131 2443781-8 1987 Polyacrylamide gel electrophoresis confirmed that the predominant protein in the 10% polyethylene glycol precipitate was fibrinogen. Polyethylene Glycols 85-104 fibrinogen beta chain Homo sapiens 121-131 3477999-2 1987 The [32P]phosphate incorporated varied between 0.5 and 1 mol of phosphate per mole of fibrinogen. Phosphorus-32 5-8 fibrinogen beta chain Homo sapiens 86-96 3477999-2 1987 The [32P]phosphate incorporated varied between 0.5 and 1 mol of phosphate per mole of fibrinogen. Phosphates 9-18 fibrinogen beta chain Homo sapiens 86-96 2447894-1 1987 A specific antibody population against human fibrinogen was isolated from a rabbit antiserum by affinity chromatography on fibrinogen-bound Sepharose gel. Sepharose 140-149 fibrinogen beta chain Homo sapiens 123-133 3497679-3 1987 In the low calcium medium, either vWf or fibrinogen supported biphasic aggregation in response to ADP, with thromboxane formation and release of granule contents. Calcium 11-18 fibrinogen beta chain Homo sapiens 41-51 3497679-3 1987 In the low calcium medium, either vWf or fibrinogen supported biphasic aggregation in response to ADP, with thromboxane formation and release of granule contents. Adenosine Diphosphate 98-101 fibrinogen beta chain Homo sapiens 41-51 3497679-0 1987 Effect of calcium ion concentration on the ability of fibrinogen and von Willebrand factor to support the ADP-induced aggregation of human platelets. Calcium 10-17 fibrinogen beta chain Homo sapiens 54-64 3497679-0 1987 Effect of calcium ion concentration on the ability of fibrinogen and von Willebrand factor to support the ADP-induced aggregation of human platelets. Adenosine Diphosphate 106-109 fibrinogen beta chain Homo sapiens 54-64 3497679-3 1987 In the low calcium medium, either vWf or fibrinogen supported biphasic aggregation in response to ADP, with thromboxane formation and release of granule contents. Thromboxanes 108-119 fibrinogen beta chain Homo sapiens 41-51 3620698-6 1987 Platelets were aggregated with adenosine diphosphate (ADP) in the presence of fibrinogen, agglutinated with polylysine, or after pretreatment with chymotrypsin, aggregated with fibrinogen. Adenosine Diphosphate 54-57 fibrinogen beta chain Homo sapiens 78-88 3438488-4 1987 These results suggested that 67Ga-DFO-DAS-fibrinogen might be a promising agent for thrombus imaging. Deferoxamine 34-37 fibrinogen beta chain Homo sapiens 42-52 3663917-1 1987 The interaction of serum low density lipoproteins (LDL) with fibrinogen, fibronectin and fibrinogen-fibronectin complex immobilized on polystyrene was studied. Polystyrenes 135-146 fibrinogen beta chain Homo sapiens 89-99 3438486-0 1987 Clinical applications of Ga-67 DFO-DAS-fibrinogen. Gallium 25-27 fibrinogen beta chain Homo sapiens 39-49 3438486-0 1987 Clinical applications of Ga-67 DFO-DAS-fibrinogen. Deferoxamine 31-34 fibrinogen beta chain Homo sapiens 39-49 3438486-1 1987 As a result of our preliminary study which confirmed the safety and promising clinical usefulness of 67Ga-DFO-DAS-fibrinogen, scintigrams were taken on seven patients with suspected thrombosis. Deferoxamine 106-109 fibrinogen beta chain Homo sapiens 114-124 3438487-0 1987 Study report--clinical application of Ga-67 DFO-DAS-fibrinogen. Deferoxamine 44-47 fibrinogen beta chain Homo sapiens 52-62 3438487-3 1987 Thrombus imagings were obtained 6-96 hours after intravenous administration of 2 mCi of 67Ga-DFO-DAS-fibrinogen (67Ga-fibrinogen). Deferoxamine 93-96 fibrinogen beta chain Homo sapiens 101-111 3438488-0 1987 Clinical use of Ga-67 DFO-DAS-fibrinogen. Gallium 16-18 fibrinogen beta chain Homo sapiens 30-40 3438488-0 1987 Clinical use of Ga-67 DFO-DAS-fibrinogen. Deferoxamine 22-25 fibrinogen beta chain Homo sapiens 30-40 3438488-1 1987 The clinical usefulness of 67Ga-DFO-DAS-fibrinogen, a newly developed thrombus imaging agent, was evaluated. Deferoxamine 32-35 fibrinogen beta chain Homo sapiens 40-50 3438488-2 1987 Fifteen cases were given 2 mCi of 67Ga-DFO-DAS-fibrinogen and images were obtained up to 96 hours after injection. Deferoxamine 39-42 fibrinogen beta chain Homo sapiens 47-57 3438483-0 1987 Arterial and venous thrombus imaging using Ga-67 DFO-DAS-fibrinogen: its clinical applicability. Deferoxamine 49-52 fibrinogen beta chain Homo sapiens 57-67 3438483-1 1987 The purpose of this study was the clinical application of 67Ga-DFO-DAS-fibrinogen 67Ga-fibrinogen in normal volunteers and patients with arterial or venous therombus, or bypass graft. Deferoxamine 63-66 fibrinogen beta chain Homo sapiens 71-81 3438483-1 1987 The purpose of this study was the clinical application of 67Ga-DFO-DAS-fibrinogen 67Ga-fibrinogen in normal volunteers and patients with arterial or venous therombus, or bypass graft. Deferoxamine 63-66 fibrinogen beta chain Homo sapiens 87-97 3438483-2 1987 DFO-DAS-fibrinogen was available as a lyophilized product and easily labeled by simple mixing with 67Ga-fibrinogen solution (2 mCi/2 ml). Deferoxamine 0-3 fibrinogen beta chain Homo sapiens 8-18 3438483-2 1987 DFO-DAS-fibrinogen was available as a lyophilized product and easily labeled by simple mixing with 67Ga-fibrinogen solution (2 mCi/2 ml). Deferoxamine 0-3 fibrinogen beta chain Homo sapiens 104-114 3438488-3 1987 Abnormal accumulation of 67Ga-DFO-DAS-fibrinogen was imaged in seven cases with either venous or arterial thrombi, and no side effects were noted. Deferoxamine 30-33 fibrinogen beta chain Homo sapiens 38-48 3118890-7 1987 Whereas cLUK significantly decreased plasma levels of alpha 2-antiplasmin, plasminogen and fibrinogen, cPUK caused only a marginal decrease in alpha 2-antiplasmin and left the plasminogen and fibrinogen levels unchanged. cluk 8-12 fibrinogen beta chain Homo sapiens 91-101 3620475-0 1987 Fibrinogen-sepharose interaction with prothrombin, prethrombin 1, prethrombin 2 and thrombin. Sepharose 11-20 fibrinogen beta chain Homo sapiens 0-10 3620475-1 1987 Binding of prothrombin, prethrombin 1, prethrombin 2 and thrombin to fibrinogen-Sepharose was studied. Sepharose 80-89 fibrinogen beta chain Homo sapiens 69-79 3620475-2 1987 Thrombin and prethrombin 2 bound to fibrinogen-Sepharose, while prethrombin 1 and prothrombin did not. Sepharose 47-56 fibrinogen beta chain Homo sapiens 36-46 3620475-4 1987 The affinity of thrombin and prethrombin 2 to fibrinogen-Sepharose depended on ionic strength and reached a maximum at 50 mm concentration. Sepharose 57-66 fibrinogen beta chain Homo sapiens 46-56 2822029-1 1987 Stimulation of human or rabbit platelets with thrombin in the presence of fibrinogen caused a large decrease, compared with unstimulated controls, in the amount of phosphatidylinositol 4,5-bisphosphate (PIP2) that could be extracted with acidified chloroform/methanol (60% at 60 s). Phosphatidylinositol 4,5-Diphosphate 164-201 fibrinogen beta chain Homo sapiens 74-84 2822029-1 1987 Stimulation of human or rabbit platelets with thrombin in the presence of fibrinogen caused a large decrease, compared with unstimulated controls, in the amount of phosphatidylinositol 4,5-bisphosphate (PIP2) that could be extracted with acidified chloroform/methanol (60% at 60 s). Phosphatidylinositol 4,5-Diphosphate 203-207 fibrinogen beta chain Homo sapiens 74-84 2822029-1 1987 Stimulation of human or rabbit platelets with thrombin in the presence of fibrinogen caused a large decrease, compared with unstimulated controls, in the amount of phosphatidylinositol 4,5-bisphosphate (PIP2) that could be extracted with acidified chloroform/methanol (60% at 60 s). Chloroform 248-258 fibrinogen beta chain Homo sapiens 74-84 2822029-1 1987 Stimulation of human or rabbit platelets with thrombin in the presence of fibrinogen caused a large decrease, compared with unstimulated controls, in the amount of phosphatidylinositol 4,5-bisphosphate (PIP2) that could be extracted with acidified chloroform/methanol (60% at 60 s). Methanol 259-267 fibrinogen beta chain Homo sapiens 74-84 3111577-9 1987 After infusion of DDAVP, results indicated that, despite baseline results, SLE patients were able to respond to stimulation and the increase in PA activity produced a decrease in plasma fibrinogen levels. Deamino Arginine Vasopressin 18-23 fibrinogen beta chain Homo sapiens 186-196 2822029-2 1987 In contrast, stimulation in the absence of added fibrinogen increased the amount of PIP2. Phosphatidylinositol 4,5-Diphosphate 84-88 fibrinogen beta chain Homo sapiens 49-59 2822029-6 1987 Thus, when platelets are stimulated with thrombin in the presence of fibrinogen, an association of polymerizing fibrin with the stimulated platelets occurs that leads to decreased extractability of PIP2. Phosphatidylinositol 4,5-Diphosphate 198-202 fibrinogen beta chain Homo sapiens 69-79 3607287-0 1987 ADP-induced platelet aggregation depends on the conformation or availability of the terminal gamma chain sequence of fibrinogen. Adenosine Diphosphate 0-3 fibrinogen beta chain Homo sapiens 117-127 3607287-4 1987 Aggregation of ADP-stimulated normal platelets was defective with fibrinogen Paris I and markedly depressed with the gamma Paris I chain. Adenosine Diphosphate 15-18 fibrinogen beta chain Homo sapiens 66-76 3607287-9 1987 These observations demonstrate that the gamma chain platelet recognition site in the fibrinogen molecule is necessary but not alone sufficient to support normal ADP-induced platelet aggregation. Adenosine Diphosphate 161-164 fibrinogen beta chain Homo sapiens 85-95 3666059-1 1987 Nonenzymatic glycation of fibrinogen is species independent and depends only on the glucose concentration in the incubation mixture under selected in vitro conditions. Glucose 84-91 fibrinogen beta chain Homo sapiens 26-36 3036276-1 1987 Human fibrinogen has an Arg-Gly-Asp-Ser (RGDS) sequence at residues 572-575 of its A alpha-chain. Arginine 24-27 fibrinogen beta chain Homo sapiens 6-16 3629559-1 1987 The CNBr-split N-terminal disulphide knot of the fibrinogen molecule (N-DSK) binds to ADP-stimulated gel-filtered platelets and immunoprecipitated fibrinogen receptor. disulphide 26-36 fibrinogen beta chain Homo sapiens 49-59 3629559-1 1987 The CNBr-split N-terminal disulphide knot of the fibrinogen molecule (N-DSK) binds to ADP-stimulated gel-filtered platelets and immunoprecipitated fibrinogen receptor. disulphide 26-36 fibrinogen beta chain Homo sapiens 147-157 3629559-1 1987 The CNBr-split N-terminal disulphide knot of the fibrinogen molecule (N-DSK) binds to ADP-stimulated gel-filtered platelets and immunoprecipitated fibrinogen receptor. Adenosine Diphosphate 86-89 fibrinogen beta chain Homo sapiens 49-59 3629559-2 1987 To investigate which part of the N-DSK molecule that is involved in this binding, the glycoprotein IIb-IIIa complex (the fibrinogen receptor) was immunoprecipitated in crossed immunoelectrophoresis of Triton X-100 extracts of platelets against rabbit antibodies to whole platelet proteins. Octoxynol 201-213 fibrinogen beta chain Homo sapiens 121-131 2958957-2 1987 Brief plasmin digestion of human fibrinogen, followed by ammonium sulfate fractionation and column chromatography, yielded a highly clottable fragment X-like preparation. Ammonium Sulfate 57-73 fibrinogen beta chain Homo sapiens 33-43 3036276-1 1987 Human fibrinogen has an Arg-Gly-Asp-Ser (RGDS) sequence at residues 572-575 of its A alpha-chain. Glycine 28-31 fibrinogen beta chain Homo sapiens 6-16 3036276-1 1987 Human fibrinogen has an Arg-Gly-Asp-Ser (RGDS) sequence at residues 572-575 of its A alpha-chain. Aspartic Acid 32-35 fibrinogen beta chain Homo sapiens 6-16 3036276-1 1987 Human fibrinogen has an Arg-Gly-Asp-Ser (RGDS) sequence at residues 572-575 of its A alpha-chain. Serine 36-39 fibrinogen beta chain Homo sapiens 6-16 3678711-8 1987 Therefore we believe to be prudent to delay the infusion of heparin for 12-18 hours after SK administration, when fibrinogen levels are beginning to increase. Heparin 60-67 fibrinogen beta chain Homo sapiens 114-124 2439238-6 1987 Analytical-recovery studies indicated that only fibrinogen and antithrombin III concentrations were altered (by 120% and 75%, respectively) during aspiration of the follicle into saline. Sodium Chloride 179-185 fibrinogen beta chain Homo sapiens 48-58 3667568-6 1987 These results indicate that the half-cystine at position 16 in the abnormal A alpha chain forms an intramolecular disulfide bridge with the same residue in the other abnormal A alpha chain and that fibrinogen Kawaguchi is a homo dimer composed of two identical abnormal halves. Cysteine 32-44 fibrinogen beta chain Homo sapiens 198-208 3660346-3 1987 Since the phosphorylated sites are located near the cross-linking sites in the A alpha-chain of fibrinogen, it is likely that the introduction of charged phosphate groups in this region prevent the lateral growth of the fibrin fibres. Phosphates 154-163 fibrinogen beta chain Homo sapiens 96-106 3117964-8 1987 Experiments with gel-filtered platelets suggested that GBS-induced platelet aggregation required both fibrinogen and heat-resistant (56 degrees C, 30 min) serum factors. gbs 55-58 fibrinogen beta chain Homo sapiens 102-112 3607284-6 1987 When the pool of GP IIb/IIIa molecules exposed on the surface of unstimulated platelets was reacted with the monoclonal antibody LJ-CP3 to block ADP-induced fibrinogen binding and platelet aggregation, stimulation with thrombin or PMA still induced substantial binding of antibody and fibrinogen, and aggregation ensued. Adenosine Diphosphate 145-148 fibrinogen beta chain Homo sapiens 157-167 3568326-2 1987 The formation of factor XIIIa-catalyzed fibrin polymers during clotting of plasma and purified fibrinogen in vivo was followed by a sodium dodecyl sulfate agarose gel technique, and an increase in both amount and size of gamma-chain cross-linked polymers was demonstrated before visible clot formation. Sodium Dodecyl Sulfate 132-154 fibrinogen beta chain Homo sapiens 95-105 3568326-2 1987 The formation of factor XIIIa-catalyzed fibrin polymers during clotting of plasma and purified fibrinogen in vivo was followed by a sodium dodecyl sulfate agarose gel technique, and an increase in both amount and size of gamma-chain cross-linked polymers was demonstrated before visible clot formation. Sepharose 155-162 fibrinogen beta chain Homo sapiens 95-105 3568326-2 1987 The formation of factor XIIIa-catalyzed fibrin polymers during clotting of plasma and purified fibrinogen in vivo was followed by a sodium dodecyl sulfate agarose gel technique, and an increase in both amount and size of gamma-chain cross-linked polymers was demonstrated before visible clot formation. Polymers 47-55 fibrinogen beta chain Homo sapiens 95-105 3584243-7 1987 To determine whether the receptors clustered before ligand binding, or as a consequence thereof, we studied the surface distribution of GPIIb-IIIa after stimulation with ADP, which causes activation of the fibrinogen receptor function of GPIIb-IIIa without inducing the release of fibrinogen. Adenosine Diphosphate 170-173 fibrinogen beta chain Homo sapiens 206-216 3584243-10 1987 Clustering was also induced by the addition of the GPIIb-IIIa-binding domains of fibrinogen, namely the tetrapeptide Arg-Gly-Asp-Ser on the alpha-chain or the gamma-chain decapeptide gamma 402-411. Arginine 117-120 fibrinogen beta chain Homo sapiens 81-91 3584243-10 1987 Clustering was also induced by the addition of the GPIIb-IIIa-binding domains of fibrinogen, namely the tetrapeptide Arg-Gly-Asp-Ser on the alpha-chain or the gamma-chain decapeptide gamma 402-411. Glycine 121-124 fibrinogen beta chain Homo sapiens 81-91 3584243-10 1987 Clustering was also induced by the addition of the GPIIb-IIIa-binding domains of fibrinogen, namely the tetrapeptide Arg-Gly-Asp-Ser on the alpha-chain or the gamma-chain decapeptide gamma 402-411. Aspartic Acid 125-128 fibrinogen beta chain Homo sapiens 81-91 3584243-10 1987 Clustering was also induced by the addition of the GPIIb-IIIa-binding domains of fibrinogen, namely the tetrapeptide Arg-Gly-Asp-Ser on the alpha-chain or the gamma-chain decapeptide gamma 402-411. Serine 129-132 fibrinogen beta chain Homo sapiens 81-91 3616571-10 1987 These studies suggest that epinephrine- and ADP-induced platelet aggregation occurs via the exposure of fibrinogen receptors on shape-changed platelets. Epinephrine 27-38 fibrinogen beta chain Homo sapiens 104-114 3616571-10 1987 These studies suggest that epinephrine- and ADP-induced platelet aggregation occurs via the exposure of fibrinogen receptors on shape-changed platelets. Adenosine Diphosphate 44-47 fibrinogen beta chain Homo sapiens 104-114 3603434-1 1987 Human fibrinogen is phosphorylated in vivo to an equal extent at two positions, one at Ser 3 located on fibrinopeptide A, the other at Ser 345 of the A alpha-chain. Serine 87-90 fibrinogen beta chain Homo sapiens 6-16 2958955-1 1987 The abnormal fibrinogen Haifa is characterized by the fact that calcium present during enzymatic digestion by plasmin does not protect the Haifa D gamma chain against further plasmin attack as it does in normal molecules. Calcium 64-71 fibrinogen beta chain Homo sapiens 13-23 3603434-1 1987 Human fibrinogen is phosphorylated in vivo to an equal extent at two positions, one at Ser 3 located on fibrinopeptide A, the other at Ser 345 of the A alpha-chain. Serine 135-138 fibrinogen beta chain Homo sapiens 6-16 3603436-2 1987 Fibrinogen binding sites were exposed by stimulating platelets with ADP or with chymotrypsin. Adenosine Diphosphate 68-71 fibrinogen beta chain Homo sapiens 0-10 3603436-4 1987 The Km values for fibrinogen mediated aggregation of ADP-stimulated platelets obtained from control and diabetic donors were 1.39 +/- 0.13 X 10(-7)M and 1.44 +/- 0.13 X 10(-7)M; the Vmax values (expressed in arbitrary light transmission units) were 87.8 +/- 3.14 and 92.8 +/- 4.5 (mean +/- S.E.M.). Adenosine Diphosphate 53-56 fibrinogen beta chain Homo sapiens 18-28 3106345-0 1987 Fibrinogen lysine residue A alpha 157 plays a crucial role in the fibrin-induced acceleration of plasminogen activation, catalyzed by tissue-type plasminogen activator. Lysine 11-17 fibrinogen beta chain Homo sapiens 0-10 3593791-1 1987 Copolymerization of fibrinogen with desAB- and desA-fibrin NH2-terminal disulfide knots (tN-DSK and rN-DSK, respectively) caused by interdomain D-E-binding was compared. Disulfides 72-81 fibrinogen beta chain Homo sapiens 20-30 3106345-3 1987 We found that the peptides with sequences identical with A alpha 148-161 and A alpha 149-161 of human fibrinogen accelerate the plasminogen activation by t-PA, whereas the corresponding peptides in which lysine residues A alpha 157 had been replaced by valine or arginine had no accelerating capacity. Lysine 204-210 fibrinogen beta chain Homo sapiens 102-112 3106345-3 1987 We found that the peptides with sequences identical with A alpha 148-161 and A alpha 149-161 of human fibrinogen accelerate the plasminogen activation by t-PA, whereas the corresponding peptides in which lysine residues A alpha 157 had been replaced by valine or arginine had no accelerating capacity. Valine 253-259 fibrinogen beta chain Homo sapiens 102-112 3106345-3 1987 We found that the peptides with sequences identical with A alpha 148-161 and A alpha 149-161 of human fibrinogen accelerate the plasminogen activation by t-PA, whereas the corresponding peptides in which lysine residues A alpha 157 had been replaced by valine or arginine had no accelerating capacity. Arginine 263-271 fibrinogen beta chain Homo sapiens 102-112 3620452-6 1987 A delay in the onset of aggregation was also shown in calcium-lacking buffers by use of either reaggregating fibrin or fibrinogen aggregated with low (0.01-0.05 unit/mL) thrombin concentrations. Calcium 54-61 fibrinogen beta chain Homo sapiens 119-129 3037720-2 1987 Fully formed fibrinogen is a six chain, disulfide-linked, dimeric molecule with a molecular weight of 340kDa. Disulfides 40-49 fibrinogen beta chain Homo sapiens 13-23 3037720-6 1987 In this study the endogenous levels of fibrinogen and its precursors are measured by two different methods; pulse and steady-state labelling with L-35 S-methionine and immunoblotting. l-35 s-methionine 146-163 fibrinogen beta chain Homo sapiens 39-49 3593791-2 1987 It was shown that only tN-DSK effectively produces with fibrinogen soluble and insoluble forms of the copolymer characterized by a constant stoichiometry which, in turn, reflects its regular structure. copolymer 102-111 fibrinogen beta chain Homo sapiens 56-66 3593791-6 1987 It is concluded that the formation of the regular polymer structure during fibrinogen and fibrin N-DSK complex formation requires the participation of two types of complementary centers, namely: D1-E1 and D2-E2. Polymers 50-57 fibrinogen beta chain Homo sapiens 75-85 2950941-3 1987 The samples were treated with cyanogen bromide (CNBr), and the total amount of fibrinogen and fibrin-derived protein was determined as NDSK, the NH2-terminal disulfide knot of fibrinogen. Disulfides 158-167 fibrinogen beta chain Homo sapiens 79-89 3548842-1 1987 The platelet membrane glycoproteins IIb (GpIIb) and GpIIIa form calcium-dependent heterodimers containing binding sites for fibrinogen, von Willebrand factor, and fibronectin. Calcium 64-71 fibrinogen beta chain Homo sapiens 124-134 3580304-8 1987 Fibrinogen Sheffield and Paris VI were identified as A alpha Arg 16----His substitutions and fibrinogens London VI and Madrid II were found to be heterozygous for an unknown substitution preventing thrombin cleavage at A alpha Arg 16. Arginine 61-64 fibrinogen beta chain Homo sapiens 0-10 3590112-0 1987 Purification of human plasma fibrinogen by chromatography on protamine-agarose. protamine-agarose 61-78 fibrinogen beta chain Homo sapiens 29-39 3590112-1 1987 A study was performed to investigate if protamine covalently attached to CNBr-activated agarose is a useful tool for the purification of fibrinogen from human plasma samples. Sepharose 88-95 fibrinogen beta chain Homo sapiens 137-147 3590112-4 1987 6.5 mg of fibrinogen were adsorbed to 1.0 ml of protamine-agarose. protamine-agarose 48-65 fibrinogen beta chain Homo sapiens 10-20 3593282-5 1987 Also, the elution profile of phenylmethane-sulphonyl fluoride-inhibited thrombin from fibrinogen-Sepharose was identical with that of active thrombin from fibrin-monomer-Sepharose. Phenylmethylsulfonyl Fluoride 29-61 fibrinogen beta chain Homo sapiens 86-96 3593282-5 1987 Also, the elution profile of phenylmethane-sulphonyl fluoride-inhibited thrombin from fibrinogen-Sepharose was identical with that of active thrombin from fibrin-monomer-Sepharose. Sepharose 97-106 fibrinogen beta chain Homo sapiens 86-96 3035741-1 1987 We have investigated the binding of fluorescein isothiocyanate (FITC)-labeled fibrinogen to platelets using a fluorescence spectrophotometer and a flow cytometer. Fluorescein-5-isothiocyanate 36-62 fibrinogen beta chain Homo sapiens 78-88 3035741-1 1987 We have investigated the binding of fluorescein isothiocyanate (FITC)-labeled fibrinogen to platelets using a fluorescence spectrophotometer and a flow cytometer. Fluorescein-5-isothiocyanate 64-68 fibrinogen beta chain Homo sapiens 78-88 3035741-2 1987 The amount of fibrinogen bound by stimulation of adenosine diphosphate (ADP) and 5-hydroxytryptamine (5HT) increased in a dose-dependent manner. Adenosine Diphosphate 49-70 fibrinogen beta chain Homo sapiens 14-24 3035741-2 1987 The amount of fibrinogen bound by stimulation of adenosine diphosphate (ADP) and 5-hydroxytryptamine (5HT) increased in a dose-dependent manner. Adenosine Diphosphate 72-75 fibrinogen beta chain Homo sapiens 14-24 3035741-2 1987 The amount of fibrinogen bound by stimulation of adenosine diphosphate (ADP) and 5-hydroxytryptamine (5HT) increased in a dose-dependent manner. Serotonin 81-100 fibrinogen beta chain Homo sapiens 14-24 3035741-2 1987 The amount of fibrinogen bound by stimulation of adenosine diphosphate (ADP) and 5-hydroxytryptamine (5HT) increased in a dose-dependent manner. Serotonin 102-105 fibrinogen beta chain Homo sapiens 14-24 3035741-4 1987 Fibrinogen could bind to platelets in response to ADP, regardless of whether they were desensitized by 5HT, and vice versa. Adenosine Diphosphate 50-53 fibrinogen beta chain Homo sapiens 0-10 3300723-4 1987 Prefixation of C. albicans with formaldehyde decreased binding of fibrinogen, and pretreatment with mercaptoethanol and pronase abolished it. Formaldehyde 32-44 fibrinogen beta chain Homo sapiens 66-76 2954261-4 1987 The abnormal fibrinogen polymerized in the presence of calcium and can be further cross-linked by factor XIIIa. Calcium 55-62 fibrinogen beta chain Homo sapiens 13-23 2954261-10 1987 Sialic acid content was markedly decreased in fibrinogen Barcelona. N-Acetylneuraminic Acid 0-11 fibrinogen beta chain Homo sapiens 46-56 3576729-3 1987 Highly molecular aggregates of fibrinogen are found to be produced mainly due to hydrogen bonds. Hydrogen 81-89 fibrinogen beta chain Homo sapiens 31-41 2827552-3 1987 At least one receptor mechanism for fibrinogen and for vWF is controlled by ADP that is secreted through the known pathways of platelet activation and counterbalanced by cyclic AMP. Adenosine Diphosphate 76-79 fibrinogen beta chain Homo sapiens 36-46 2827552-3 1987 At least one receptor mechanism for fibrinogen and for vWF is controlled by ADP that is secreted through the known pathways of platelet activation and counterbalanced by cyclic AMP. Cyclic AMP 170-180 fibrinogen beta chain Homo sapiens 36-46 3101598-1 1987 Phosphorylation of human fibrinogen in vitro by incubation with [gamma-32P]ATP and protein kinase C purified from pig spleen, led to incorporation of [32P]phosphate at serine residues located in the A alpha-chain. [gamma-32p]atp 64-78 fibrinogen beta chain Homo sapiens 25-35 3101598-1 1987 Phosphorylation of human fibrinogen in vitro by incubation with [gamma-32P]ATP and protein kinase C purified from pig spleen, led to incorporation of [32P]phosphate at serine residues located in the A alpha-chain. Phosphorus-32 71-74 fibrinogen beta chain Homo sapiens 25-35 3101598-1 1987 Phosphorylation of human fibrinogen in vitro by incubation with [gamma-32P]ATP and protein kinase C purified from pig spleen, led to incorporation of [32P]phosphate at serine residues located in the A alpha-chain. Phosphates 155-164 fibrinogen beta chain Homo sapiens 25-35 3101598-1 1987 Phosphorylation of human fibrinogen in vitro by incubation with [gamma-32P]ATP and protein kinase C purified from pig spleen, led to incorporation of [32P]phosphate at serine residues located in the A alpha-chain. Serine 168-174 fibrinogen beta chain Homo sapiens 25-35 3101598-2 1987 In order to identify the residues that were phosphorylated, the A alpha-chain of fibrinogen was isolated and subjected to consecutive cleavage by cyanogen bromide, trypsin, and chymotrypsin. Cyanogen Bromide 146-162 fibrinogen beta chain Homo sapiens 81-91 3101598-6 1987 This region also contains lysine residues participating in the cross-linking of fibrin and, possibly, a site involved in the binding of fibrinogen to receptors on platelets. Lysine 26-32 fibrinogen beta chain Homo sapiens 136-146 2890169-0 1987 Fibrinogen and liver function parameters during PGE1-therapy. Alprostadil 48-52 fibrinogen beta chain Homo sapiens 0-10 3111087-3 1987 Contaminating fibrinogen was precipitated by the addition of 2.8 M glycine buffer at 30 degrees C. The fibrinogen precipitate was removed by filtration using a layer of glass beads. Glycine 67-74 fibrinogen beta chain Homo sapiens 14-24 3101672-0 1986 Platelet-activating factor (PAF-acether) induces high- and low-affinity binding of fibrinogen to human platelets via independent mechanisms. Platelet Activating Factor 28-39 fibrinogen beta chain Homo sapiens 83-93 3101672-11 1986 The amounts of thromboxane A2 and secreted ADP, however, are sufficient for initiating high- and low-affinity fibrinogen binding via mutually independent mechanisms. Adenosine Diphosphate 43-46 fibrinogen beta chain Homo sapiens 110-120 3779100-0 1986 Expression of fibrinogen receptors during activation and subsequent desensitization of human platelets by epinephrine. Epinephrine 106-117 fibrinogen beta chain Homo sapiens 14-24 3779100-4 1986 The current studies were designed to examine the effect of occupancy of platelet alpha 2-adrenergic receptors by epinephrine on the expression of fibrinogen receptors and on the aggregation of platelets. Epinephrine 113-124 fibrinogen beta chain Homo sapiens 146-156 3779100-5 1986 The ability of epinephrine to induce the expression of fibrinogen receptors was studied under two different conditions: acute stimulation (less than 1 min) and prolonged stimulation (50 to 90 min), the latter of which is associated with a reduction or "desensitization" of the platelet aggregation response. Epinephrine 15-26 fibrinogen beta chain Homo sapiens 55-65 3779100-7 1986 Epinephrine caused an immediate increase in PAC-1 and fibrinogen binding that was dependent on occupancy of the alpha 2-receptor by epinephrine and on the presence of extracellular free Ca (KCa = 30 mumol/L). Epinephrine 0-11 fibrinogen beta chain Homo sapiens 54-64 3779100-7 1986 Epinephrine caused an immediate increase in PAC-1 and fibrinogen binding that was dependent on occupancy of the alpha 2-receptor by epinephrine and on the presence of extracellular free Ca (KCa = 30 mumol/L). Epinephrine 132-143 fibrinogen beta chain Homo sapiens 54-64 3779100-15 1986 Ca-dependent reactions subsequent to fibrinogen binding may be necessary for maximal platelet aggregation and are impaired when platelets become desensitized to epinephrine. Epinephrine 161-172 fibrinogen beta chain Homo sapiens 37-47 3024170-3 1986 Epinephrine evokes (i) an increased turnover of ester-linked arachidonic acid in aspirin treated platelets that is inhibited by ONO-RS-082, EDTA, yohimbine, or the absence of fibrinogen and (ii) a rapid cytoplasmic alkalinization that is inhibited partially by blockage of cyclooxygenase activity and completely by A2A9 or EIPA. Esters 48-53 fibrinogen beta chain Homo sapiens 175-185 3024170-3 1986 Epinephrine evokes (i) an increased turnover of ester-linked arachidonic acid in aspirin treated platelets that is inhibited by ONO-RS-082, EDTA, yohimbine, or the absence of fibrinogen and (ii) a rapid cytoplasmic alkalinization that is inhibited partially by blockage of cyclooxygenase activity and completely by A2A9 or EIPA. Epinephrine 0-11 fibrinogen beta chain Homo sapiens 175-185 3024170-5 1986 We propose that epinephrine, in promoting exposure of glycoprotein IIb/IIIa sites for fibrinogen binding, leads to a cytoplasmic alkalinization, which, in conjunction with local shifts in Ca2+, promotes low-level activation of phospholipase A. Epinephrine 16-27 fibrinogen beta chain Homo sapiens 86-96 3810563-3 1986 All fragments tested except for E derived from fibrinogen (Efg) and Degta bound specifically to the platelets and inhibited ADP-induced aggregation in the presence of fibrinogen. degta 68-73 fibrinogen beta chain Homo sapiens 167-177 3810563-3 1986 All fragments tested except for E derived from fibrinogen (Efg) and Degta bound specifically to the platelets and inhibited ADP-induced aggregation in the presence of fibrinogen. Adenosine Diphosphate 124-127 fibrinogen beta chain Homo sapiens 47-57 2877981-4 1986 The resulting alpha 2PI fibrinogen A alpha chain complex was separated and subjected to two cycles of Edman degradation using phenyl isothiocyanate for the first cycle and dimethylaminoazobenzene-isothiocyanate for the second cycle. edman 102-107 fibrinogen beta chain Homo sapiens 24-34 2877981-4 1986 The resulting alpha 2PI fibrinogen A alpha chain complex was separated and subjected to two cycles of Edman degradation using phenyl isothiocyanate for the first cycle and dimethylaminoazobenzene-isothiocyanate for the second cycle. phenylisothiocyanate 126-147 fibrinogen beta chain Homo sapiens 24-34 2877981-4 1986 The resulting alpha 2PI fibrinogen A alpha chain complex was separated and subjected to two cycles of Edman degradation using phenyl isothiocyanate for the first cycle and dimethylaminoazobenzene-isothiocyanate for the second cycle. dimethylaminoazobenzene isothiocyanate 172-210 fibrinogen beta chain Homo sapiens 24-34 2877981-8 1986 The peptide contains a single lysine at position 303, indicating that Lys-303 of fibrinogen A alpha chain is the lysine residue that forms a cross-link with Gln-2 of alpha 2PI. Lysine 30-36 fibrinogen beta chain Homo sapiens 81-91 2877981-8 1986 The peptide contains a single lysine at position 303, indicating that Lys-303 of fibrinogen A alpha chain is the lysine residue that forms a cross-link with Gln-2 of alpha 2PI. Lysine 70-73 fibrinogen beta chain Homo sapiens 81-91 2877981-8 1986 The peptide contains a single lysine at position 303, indicating that Lys-303 of fibrinogen A alpha chain is the lysine residue that forms a cross-link with Gln-2 of alpha 2PI. Lysine 113-119 fibrinogen beta chain Homo sapiens 81-91 2877981-8 1986 The peptide contains a single lysine at position 303, indicating that Lys-303 of fibrinogen A alpha chain is the lysine residue that forms a cross-link with Gln-2 of alpha 2PI. Glutamine 157-160 fibrinogen beta chain Homo sapiens 81-91 3778045-3 1986 Heparin solutions (100 U/mL, US Pharmacopoela) used to prevent the formation of clots within the HC appeared to cause, to a significant degree, spuriously elevated levels of fibrin degradation products (FDP), decreased levels of fibrinogen (FBG), and prolongations of the prothrombin time (PT) and activated partial thromboplastin time (PTT) in the first 10 mL of HC blood. Heparin 0-7 fibrinogen beta chain Homo sapiens 229-239 3536934-6 1986 Materials, which induced strong in vitro platelet activation, e.g. low density polyethylene and polyvinylchloride, demonstrated high concentrations of fibrinogen and platelets on the surface when tested under ex vivo conditions. density 71-78 fibrinogen beta chain Homo sapiens 151-161 3536934-6 1986 Materials, which induced strong in vitro platelet activation, e.g. low density polyethylene and polyvinylchloride, demonstrated high concentrations of fibrinogen and platelets on the surface when tested under ex vivo conditions. Polyethylene 79-91 fibrinogen beta chain Homo sapiens 151-161 3536934-6 1986 Materials, which induced strong in vitro platelet activation, e.g. low density polyethylene and polyvinylchloride, demonstrated high concentrations of fibrinogen and platelets on the surface when tested under ex vivo conditions. Polyvinyl Chloride 96-113 fibrinogen beta chain Homo sapiens 151-161 3536934-7 1986 Polydimethylsiloxane and polyetherurethane, which induced slight in vitro platelet factor 4 release, absorbed significantly lower concentrations of fibrinogen and platelets from human native blood. baysilon 0-20 fibrinogen beta chain Homo sapiens 148-158 3536934-7 1986 Polydimethylsiloxane and polyetherurethane, which induced slight in vitro platelet factor 4 release, absorbed significantly lower concentrations of fibrinogen and platelets from human native blood. polyetherurethane 25-42 fibrinogen beta chain Homo sapiens 148-158 3772299-1 1986 Human monocytes potentiate the ADP-stimulated aggregation of autologous platelets through a fourfold increased binding of 125I-fibrinogen to the platelet surface. Adenosine Diphosphate 31-34 fibrinogen beta chain Homo sapiens 127-137 3593464-3 1987 When investigated while abstaining from nicotine for 8 weeks, chronic cigarette smokers show a gradual normalization of blood and plasma viscosities, haematocrit, blood cell filterability, plasma fibrinogen levels as well as total white cell count. Nicotine 40-48 fibrinogen beta chain Homo sapiens 196-206 3814824-1 1987 The alpha chain 572-574 Arg-Gly-Asp sequence of fibrinogen appears to play only a minor role in platelet aggregation based on the ability of fibrinogen preparations lacking alpha chain carboxyterminal segments to support platelet aggregation, but synthetic Arg-Gly-Asp-Ser (RGDS) peptides are capable of inhibiting platelet aggregation and fibrinogen binding. Arginine 24-27 fibrinogen beta chain Homo sapiens 48-58 3814824-1 1987 The alpha chain 572-574 Arg-Gly-Asp sequence of fibrinogen appears to play only a minor role in platelet aggregation based on the ability of fibrinogen preparations lacking alpha chain carboxyterminal segments to support platelet aggregation, but synthetic Arg-Gly-Asp-Ser (RGDS) peptides are capable of inhibiting platelet aggregation and fibrinogen binding. Glycine 28-31 fibrinogen beta chain Homo sapiens 48-58 3814824-1 1987 The alpha chain 572-574 Arg-Gly-Asp sequence of fibrinogen appears to play only a minor role in platelet aggregation based on the ability of fibrinogen preparations lacking alpha chain carboxyterminal segments to support platelet aggregation, but synthetic Arg-Gly-Asp-Ser (RGDS) peptides are capable of inhibiting platelet aggregation and fibrinogen binding. Aspartic Acid 32-35 fibrinogen beta chain Homo sapiens 48-58 3814824-1 1987 The alpha chain 572-574 Arg-Gly-Asp sequence of fibrinogen appears to play only a minor role in platelet aggregation based on the ability of fibrinogen preparations lacking alpha chain carboxyterminal segments to support platelet aggregation, but synthetic Arg-Gly-Asp-Ser (RGDS) peptides are capable of inhibiting platelet aggregation and fibrinogen binding. Arginine 257-260 fibrinogen beta chain Homo sapiens 48-58 3814824-1 1987 The alpha chain 572-574 Arg-Gly-Asp sequence of fibrinogen appears to play only a minor role in platelet aggregation based on the ability of fibrinogen preparations lacking alpha chain carboxyterminal segments to support platelet aggregation, but synthetic Arg-Gly-Asp-Ser (RGDS) peptides are capable of inhibiting platelet aggregation and fibrinogen binding. Glycine 261-264 fibrinogen beta chain Homo sapiens 48-58 3814824-1 1987 The alpha chain 572-574 Arg-Gly-Asp sequence of fibrinogen appears to play only a minor role in platelet aggregation based on the ability of fibrinogen preparations lacking alpha chain carboxyterminal segments to support platelet aggregation, but synthetic Arg-Gly-Asp-Ser (RGDS) peptides are capable of inhibiting platelet aggregation and fibrinogen binding. Aspartic Acid 265-268 fibrinogen beta chain Homo sapiens 48-58 3814824-1 1987 The alpha chain 572-574 Arg-Gly-Asp sequence of fibrinogen appears to play only a minor role in platelet aggregation based on the ability of fibrinogen preparations lacking alpha chain carboxyterminal segments to support platelet aggregation, but synthetic Arg-Gly-Asp-Ser (RGDS) peptides are capable of inhibiting platelet aggregation and fibrinogen binding. Serine 269-272 fibrinogen beta chain Homo sapiens 48-58 3469204-2 1987 The peptide was designed to be triple helical and to contain the sequence Arg-Gly-Asp, which has been implicated as the cell attachment site of fibronectin, vitronectin, fibrinogen, and von Willebrand factor, and is also present in type I collagen. Arginine 74-77 fibrinogen beta chain Homo sapiens 170-180 3469204-2 1987 The peptide was designed to be triple helical and to contain the sequence Arg-Gly-Asp, which has been implicated as the cell attachment site of fibronectin, vitronectin, fibrinogen, and von Willebrand factor, and is also present in type I collagen. Glycine 78-81 fibrinogen beta chain Homo sapiens 170-180 3469204-2 1987 The peptide was designed to be triple helical and to contain the sequence Arg-Gly-Asp, which has been implicated as the cell attachment site of fibronectin, vitronectin, fibrinogen, and von Willebrand factor, and is also present in type I collagen. Aspartic Acid 82-85 fibrinogen beta chain Homo sapiens 170-180 3558447-2 1987 Adsorption of chemically radiolabeled [14C] collagen from binary mixtures with albumin or fibrinogen was studied on the solution/air and solution/polyethylene interfaces and revealed the preferential adsorption of albumin. Carbon-14 39-42 fibrinogen beta chain Homo sapiens 90-100 3558447-2 1987 Adsorption of chemically radiolabeled [14C] collagen from binary mixtures with albumin or fibrinogen was studied on the solution/air and solution/polyethylene interfaces and revealed the preferential adsorption of albumin. Polyethylene 146-158 fibrinogen beta chain Homo sapiens 90-100 3558447-4 1987 Desorption experiments clearly show that more irreversibly adsorbed collagen was found on polyethylene surfaces when adsorption was performed from collagen-fibrinogen than from collagen-albumin solutions. Polyethylene 90-102 fibrinogen beta chain Homo sapiens 156-166 3309160-7 1987 Inhibition experiments using C. albicans dialysed culture filtrate, C. albicans mannan, chitin, sugars or amino sugars were done by preabsorbing the fibrinogen with each of the above mentioned compounds. Amino Sugars 106-118 fibrinogen beta chain Homo sapiens 149-159 3589609-2 1987 The theory was confirmed from the experiments which employed antifibrinogen gold markers to label fibrinogen molecules adsorbed on the polyethylene surface. Polyethylene 135-147 fibrinogen beta chain Homo sapiens 65-75 3589609-8 1987 The staining of fibrinogen molecules adsorbed on the polyethylene surface at three different temperatures shows a temperature dependence which is in close agreement with the theory. Polyethylene 53-65 fibrinogen beta chain Homo sapiens 16-26 2879842-7 1987 Examination of thrombospondin cross-linkage in the presence of other protein substrates (fibronectin, collagen, fibrinogen, and von Willebrand factor) for factor XIIIa, resulted in reduced thrombospondin polymer formation. thrombospondin polymer 189-211 fibrinogen beta chain Homo sapiens 102-167 3567249-3 1987 When the fibrinogen D2-site was blocked by tetrapeptide Gly-His-Arg-Pro, the key structure of the E2-site, the inhibitory activity of fibrinogen diminished. glycylhistidine 56-63 fibrinogen beta chain Homo sapiens 9-19 3567249-3 1987 When the fibrinogen D2-site was blocked by tetrapeptide Gly-His-Arg-Pro, the key structure of the E2-site, the inhibitory activity of fibrinogen diminished. glycylhistidine 56-63 fibrinogen beta chain Homo sapiens 134-144 3567249-3 1987 When the fibrinogen D2-site was blocked by tetrapeptide Gly-His-Arg-Pro, the key structure of the E2-site, the inhibitory activity of fibrinogen diminished. arginylproline 64-71 fibrinogen beta chain Homo sapiens 9-19 3567249-3 1987 When the fibrinogen D2-site was blocked by tetrapeptide Gly-His-Arg-Pro, the key structure of the E2-site, the inhibitory activity of fibrinogen diminished. arginylproline 64-71 fibrinogen beta chain Homo sapiens 134-144 3567249-5 1987 The concentration dependence of the tetrapeptide Gly-His-Arg-Pro-induced inactivation of fibrinogen and the effects of temperature and Ca2+ on the tetrapeptide interaction with fibrinogen were investigated. glycylhistidine 49-56 fibrinogen beta chain Homo sapiens 89-99 3567249-5 1987 The concentration dependence of the tetrapeptide Gly-His-Arg-Pro-induced inactivation of fibrinogen and the effects of temperature and Ca2+ on the tetrapeptide interaction with fibrinogen were investigated. arginylproline 57-64 fibrinogen beta chain Homo sapiens 89-99 2434508-1 1987 The inhibitory effect of heparin and antithrombin III (AT) on the interaction of fibrinogen and thrombin was investigated in preference to studies on heparinizing devices. Heparin 25-32 fibrinogen beta chain Homo sapiens 81-91 2434508-7 1987 The reaction of heparin with fibrinogen and thrombin in the presence of AT was well-explained by assuming a Freundlich-type adsorption of heparin analogous with the reaction of heparin with fibrinogen. Heparin 16-23 fibrinogen beta chain Homo sapiens 29-39 2434508-7 1987 The reaction of heparin with fibrinogen and thrombin in the presence of AT was well-explained by assuming a Freundlich-type adsorption of heparin analogous with the reaction of heparin with fibrinogen. Heparin 16-23 fibrinogen beta chain Homo sapiens 190-200 2434508-7 1987 The reaction of heparin with fibrinogen and thrombin in the presence of AT was well-explained by assuming a Freundlich-type adsorption of heparin analogous with the reaction of heparin with fibrinogen. Heparin 138-145 fibrinogen beta chain Homo sapiens 29-39 2434508-7 1987 The reaction of heparin with fibrinogen and thrombin in the presence of AT was well-explained by assuming a Freundlich-type adsorption of heparin analogous with the reaction of heparin with fibrinogen. Heparin 138-145 fibrinogen beta chain Homo sapiens 190-200 2470071-1 1987 The degradation rate of poly(L-lactide) microcapsules in an aqueous medium was accelerated by the addition of albumin, gamma-globulins, and fibrinogen. poly(lactide) 24-39 fibrinogen beta chain Homo sapiens 119-150 3596359-4 1987 On the other hand, the infusion of vitamin C to the fibrinogen blood cells system dramatically inhibits the fibrinogen surface binding. Ascorbic Acid 35-44 fibrinogen beta chain Homo sapiens 52-62 3596359-4 1987 On the other hand, the infusion of vitamin C to the fibrinogen blood cells system dramatically inhibits the fibrinogen surface binding. Ascorbic Acid 35-44 fibrinogen beta chain Homo sapiens 108-118 3805107-7 1987 The results indicate that the ACT and PTT after giving heparin depended on HNA rather than the patients" weight, and are related to the fibrinogen concentration. Heparin 55-62 fibrinogen beta chain Homo sapiens 136-146 3587694-0 1987 [Blood fibrinogen as a prognostic index in ulcer therapy with ranitidine]. Ranitidine 62-72 fibrinogen beta chain Homo sapiens 7-17 3563970-8 1986 The same peptide was also isolated following cyanogen bromide treatment of the intact fibrinogen Perugia. Cyanogen Bromide 45-61 fibrinogen beta chain Homo sapiens 86-96 2821151-0 1986 A randomised controlled trial to investigate the effect of a high fibre diet on blood pressure and plasma fibrinogen. fibre 66-71 fibrinogen beta chain Homo sapiens 106-116 3800991-0 1986 The molecular basis of the antiplatelet action of ajoene: direct interaction with the fibrinogen receptor. ajoene 50-56 fibrinogen beta chain Homo sapiens 86-96 3800991-1 1986 Ajoene, the major antiplatelet compound derived from garlic inhibits the fibrinogen-supported aggregation of washed human platelets (ID50 = 13 microM) and, inhibits binding of 125I-fibrinogen to ADP-stimulated platelets (ID50 = 0.8 microM). ajoene 0-6 fibrinogen beta chain Homo sapiens 73-83 3800991-1 1986 Ajoene, the major antiplatelet compound derived from garlic inhibits the fibrinogen-supported aggregation of washed human platelets (ID50 = 13 microM) and, inhibits binding of 125I-fibrinogen to ADP-stimulated platelets (ID50 = 0.8 microM). ajoene 0-6 fibrinogen beta chain Homo sapiens 181-191 3800991-1 1986 Ajoene, the major antiplatelet compound derived from garlic inhibits the fibrinogen-supported aggregation of washed human platelets (ID50 = 13 microM) and, inhibits binding of 125I-fibrinogen to ADP-stimulated platelets (ID50 = 0.8 microM). Adenosine Diphosphate 195-198 fibrinogen beta chain Homo sapiens 181-191 3800991-3 1986 Furthermore, fibrinogen-induced aggregation of chymotrypsin-treated platelets is also inhibited by ajoene in a dose-dependent manner (ID50 = 2.3 microM). ajoene 99-105 fibrinogen beta chain Homo sapiens 13-23 3800991-6 1986 These results indicate that the antiaggregatory effect of ajoene is causally related to its direct interaction with the putative fibrinogen receptor. ajoene 58-64 fibrinogen beta chain Homo sapiens 129-139 3593880-3 1987 Two fluorescent derivatives of human fibrinogen have been synthesized, by the covalent bonding of 1-dimethylaminoaphthalene-5-sulphonyl and methylpyrene chromophores, to investigate the internal molecular dynamics of the protein in solution. 1-dimethylaminoaphthalene-5-sulphonyl and methylpyrene 98-152 fibrinogen beta chain Homo sapiens 37-47 3593881-6 1987 This rigid and highly hydrated structure (4 g water/g protein) accommodates the latest nodular models obtained from electron microscopy, explains the singular hydrodynamics of fibrinogen and, apparently, it would perform the two main functions of the protein in haemostasis, blood coagulation and platelet aggregation, more efficiently than the flexible molecule. Water 46-51 fibrinogen beta chain Homo sapiens 176-186 3771533-12 1986 125I-fibrinogen bound to the associated complex (not the dissociated complex), to the Ca2+-reassociated complex, and to the neuraminidase-reassociated complex which had been dissociated with EGTA. Egtazic Acid 191-195 fibrinogen beta chain Homo sapiens 5-15 3760194-2 1986 After stimulation with ADP (10 microM) or thrombin (1 U/ml), platelet-free suspensions of human monocytes bind 125I-fibrinogen with two different affinities in a specific and Ca2+-dependent reaction with saturation at 5.80-7.35 X 10(-7) M of added protein. Adenosine Diphosphate 23-26 fibrinogen beta chain Homo sapiens 116-126 2944746-10 1986 260, 4133-4138] have shown that a tetrapeptide, Arg-Gly-Asp-Ser, inhibited the binding of fibrinogen, fibronectin, and von Willebrand factor (vWf) to stimulated platelets and that fibrinogen competes with vWf and fibronectin for binding. Arginine 48-51 fibrinogen beta chain Homo sapiens 90-100 3762281-4 1986 We found that fibrinogen precipitation using the ammonium sulfate method produced the highest concentration. Ammonium Sulfate 49-65 fibrinogen beta chain Homo sapiens 14-24 3745204-0 1986 Human fibrinogen specifically binds hyaluronic acid. Hyaluronic Acid 36-51 fibrinogen beta chain Homo sapiens 6-16 3745204-3 1986 Purified human fibrinogen specifically bound to HA-Sepharose to a greater extent (greater than 5-fold) than did alpha 1-acid glycoprotein, DNaseI, ovalbumin, haptoglobin, or lysozyme. Hyaluronic Acid 48-50 fibrinogen beta chain Homo sapiens 15-25 3745204-3 1986 Purified human fibrinogen specifically bound to HA-Sepharose to a greater extent (greater than 5-fold) than did alpha 1-acid glycoprotein, DNaseI, ovalbumin, haptoglobin, or lysozyme. Sepharose 51-60 fibrinogen beta chain Homo sapiens 15-25 3745204-5 1986 Treatment of HA-Sepharose containing bound 125I-fibrinogen with ovine testicular hyaluronidase released 44% of the 125I radioactivity, indicating that fibrinogen was specifically bound to HA. Sepharose 16-25 fibrinogen beta chain Homo sapiens 48-58 3745204-5 1986 Treatment of HA-Sepharose containing bound 125I-fibrinogen with ovine testicular hyaluronidase released 44% of the 125I radioactivity, indicating that fibrinogen was specifically bound to HA. Sepharose 16-25 fibrinogen beta chain Homo sapiens 151-161 3745204-6 1986 Moreover, 125I-fibrinogen bound to HA-Sepharose could be displaced by free HA but not by either of the monosaccharide components of this polymer, glucuronic acid, or N-acetylglucosamine. Sepharose 38-47 fibrinogen beta chain Homo sapiens 15-25 3745204-7 1986 Chondroitin sulfate and polygalacturonic acid competed only weakly for bound 125I-fibrinogen. Chondroitin Sulfates 0-19 fibrinogen beta chain Homo sapiens 82-92 3745204-10 1986 Small HA oligosaccharides (Mr = 3900) were only 50% as effective as larger HA (Mr = 8 X 10(5)) in eluting bound 125I-fibrinogen from HA-Sepharose. Oligosaccharides 9-25 fibrinogen beta chain Homo sapiens 117-127 3745204-10 1986 Small HA oligosaccharides (Mr = 3900) were only 50% as effective as larger HA (Mr = 8 X 10(5)) in eluting bound 125I-fibrinogen from HA-Sepharose. Sepharose 136-145 fibrinogen beta chain Homo sapiens 117-127 3745204-11 1986 The optimal oligosaccharide size for displacement of bound 125I-fibrinogen was greater than or equal to 200 monosaccharides. Oligosaccharides 12-27 fibrinogen beta chain Homo sapiens 64-74 3745204-11 1986 The optimal oligosaccharide size for displacement of bound 125I-fibrinogen was greater than or equal to 200 monosaccharides. Monosaccharides 108-123 fibrinogen beta chain Homo sapiens 64-74 3745204-12 1986 Additionally, the amount of 125I-fibrinogen bound to HA-Sepharose was directly related to the size of the HA-amine linked to the affinity support. Sepharose 56-65 fibrinogen beta chain Homo sapiens 33-43 3745204-12 1986 Additionally, the amount of 125I-fibrinogen bound to HA-Sepharose was directly related to the size of the HA-amine linked to the affinity support. ha-amine 106-114 fibrinogen beta chain Homo sapiens 33-43 3745204-13 1986 The affinity constant for fibrinogen binding to 125I-HA (approximately 150 monosaccharides) is estimated to be at least 2 X 10(7) M-1. Monosaccharides 75-90 fibrinogen beta chain Homo sapiens 26-36 3800968-0 1986 PAF-acether (1-O-hexadecyl/octadecyl-2-acetyl-sn-glycero-3-phosphocholine)-induced fibrinogen binding to platelets depends on metabolic energy. Platelet Activating Factor 0-11 fibrinogen beta chain Homo sapiens 83-93 3800968-0 1986 PAF-acether (1-O-hexadecyl/octadecyl-2-acetyl-sn-glycero-3-phosphocholine)-induced fibrinogen binding to platelets depends on metabolic energy. 1-o-hexadecyl/octadecyl-2-acetyl-sn-glycero-3-phosphocholine 13-73 fibrinogen beta chain Homo sapiens 83-93 3800968-1 1986 A combination of CN- and 2-deoxy-D-glucose decreases the binding of fibrinogen to platelets stimulated with PAF-acether (1-O-hexadecyl/octadecyl-2-acetyl-sn-glycero-3-phosphocholine). cn- and 17-24 fibrinogen beta chain Homo sapiens 68-78 3800968-1 1986 A combination of CN- and 2-deoxy-D-glucose decreases the binding of fibrinogen to platelets stimulated with PAF-acether (1-O-hexadecyl/octadecyl-2-acetyl-sn-glycero-3-phosphocholine). Deoxyglucose 25-42 fibrinogen beta chain Homo sapiens 68-78 3800968-1 1986 A combination of CN- and 2-deoxy-D-glucose decreases the binding of fibrinogen to platelets stimulated with PAF-acether (1-O-hexadecyl/octadecyl-2-acetyl-sn-glycero-3-phosphocholine). Platelet Activating Factor 108-119 fibrinogen beta chain Homo sapiens 68-78 3800968-1 1986 A combination of CN- and 2-deoxy-D-glucose decreases the binding of fibrinogen to platelets stimulated with PAF-acether (1-O-hexadecyl/octadecyl-2-acetyl-sn-glycero-3-phosphocholine). 1-o-hexadecyl/octadecyl-2-acetyl-sn-glycero-3-phosphocholine 121-181 fibrinogen beta chain Homo sapiens 68-78 2944746-10 1986 260, 4133-4138] have shown that a tetrapeptide, Arg-Gly-Asp-Ser, inhibited the binding of fibrinogen, fibronectin, and von Willebrand factor (vWf) to stimulated platelets and that fibrinogen competes with vWf and fibronectin for binding. Arginine 48-51 fibrinogen beta chain Homo sapiens 180-190 2944746-10 1986 260, 4133-4138] have shown that a tetrapeptide, Arg-Gly-Asp-Ser, inhibited the binding of fibrinogen, fibronectin, and von Willebrand factor (vWf) to stimulated platelets and that fibrinogen competes with vWf and fibronectin for binding. Gly-Asp-Ser 52-63 fibrinogen beta chain Homo sapiens 90-100 2944746-10 1986 260, 4133-4138] have shown that a tetrapeptide, Arg-Gly-Asp-Ser, inhibited the binding of fibrinogen, fibronectin, and von Willebrand factor (vWf) to stimulated platelets and that fibrinogen competes with vWf and fibronectin for binding. Gly-Asp-Ser 52-63 fibrinogen beta chain Homo sapiens 180-190 3778998-5 1986 The incorporation of PEGME resulted in a substantial reduction in fibrinogen adsorption as compared to the model network (PPG + PGPMS only), but the expected concomitant decrease in platelet adhesion was not observed. monomethoxypolyethylene glycol 21-26 fibrinogen beta chain Homo sapiens 66-76 3778998-0 1986 Fibrinogen adsorption and platelet adhesion at the surface of modified polypropylene glycol/polysiloxane networks. polypropylene glycol 71-91 fibrinogen beta chain Homo sapiens 0-10 3778998-0 1986 Fibrinogen adsorption and platelet adhesion at the surface of modified polypropylene glycol/polysiloxane networks. Siloxanes 92-104 fibrinogen beta chain Homo sapiens 0-10 3778998-2 1986 This study examines the role of fibrinogen in platelet adhesion at the surface of crosslinked polypropylene glycol (PPG)/polyglycidoxy propyl methyl siloxane (PGPMS) networks which contain polyethylene glycol monomethyl ether (PEGME) chains. polypropylene glycol 94-114 fibrinogen beta chain Homo sapiens 32-42 3015954-0 1986 Kinetics of platelet-activating factor 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine-induced fibrinogen binding to human platelets. o-alkyl-2-acetyl-sn-glycero-3-phosphocholine 41-85 fibrinogen beta chain Homo sapiens 94-104 3778998-2 1986 This study examines the role of fibrinogen in platelet adhesion at the surface of crosslinked polypropylene glycol (PPG)/polyglycidoxy propyl methyl siloxane (PGPMS) networks which contain polyethylene glycol monomethyl ether (PEGME) chains. polypropylene glycol 116-119 fibrinogen beta chain Homo sapiens 32-42 3778998-2 1986 This study examines the role of fibrinogen in platelet adhesion at the surface of crosslinked polypropylene glycol (PPG)/polyglycidoxy propyl methyl siloxane (PGPMS) networks which contain polyethylene glycol monomethyl ether (PEGME) chains. polyglycidoxy propyl methyl siloxane 121-157 fibrinogen beta chain Homo sapiens 32-42 3742050-2 1986 Purified fibrinogen analyzed on SDS-polyacrylamide gel electrophoresis under the reduced condition contained an abnormal protein band with an apparent molecular weight of 48,000 compared with the gamma chain with a molecular weight of 50,000. Sodium Dodecyl Sulfate 32-35 fibrinogen beta chain Homo sapiens 9-19 3742050-2 1986 Purified fibrinogen analyzed on SDS-polyacrylamide gel electrophoresis under the reduced condition contained an abnormal protein band with an apparent molecular weight of 48,000 compared with the gamma chain with a molecular weight of 50,000. polyacrylamide 36-50 fibrinogen beta chain Homo sapiens 9-19 3018111-2 1986 Correction by arachidonic acid of the impaired exposure of fibrinogen receptors by adenosine diphosphate or collagen. Arachidonic Acid 14-30 fibrinogen beta chain Homo sapiens 59-69 3018111-2 1986 Correction by arachidonic acid of the impaired exposure of fibrinogen receptors by adenosine diphosphate or collagen. Adenosine Diphosphate 83-104 fibrinogen beta chain Homo sapiens 59-69 3018111-8 1986 Therefore, we investigated the binding of iodine 125-labeled fibrinogen to uremic platelets exposed to ADP, collagen, or arachidonic acid as single agents and as pairs. Iodine 42-48 fibrinogen beta chain Homo sapiens 61-71 3018111-8 1986 Therefore, we investigated the binding of iodine 125-labeled fibrinogen to uremic platelets exposed to ADP, collagen, or arachidonic acid as single agents and as pairs. Adenosine Diphosphate 103-106 fibrinogen beta chain Homo sapiens 61-71 3018111-8 1986 Therefore, we investigated the binding of iodine 125-labeled fibrinogen to uremic platelets exposed to ADP, collagen, or arachidonic acid as single agents and as pairs. Arachidonic Acid 121-137 fibrinogen beta chain Homo sapiens 61-71 3018111-9 1986 When aggregation and binding were studied in response to ADP, collagen, or the combination of ADP with collagen, uremic platelets had reduced aggregation and bound abnormally low amounts of fibrinogen. Adenosine Diphosphate 94-97 fibrinogen beta chain Homo sapiens 190-200 3018111-10 1986 In contrast, platelets from patients with uremia bound as much 125I-fibrinogen and aggregated as well as controls when ADP or collagen were used in combination with low concentrations of arachidonic acid. Adenosine Diphosphate 119-122 fibrinogen beta chain Homo sapiens 68-78 3018111-10 1986 In contrast, platelets from patients with uremia bound as much 125I-fibrinogen and aggregated as well as controls when ADP or collagen were used in combination with low concentrations of arachidonic acid. Arachidonic Acid 187-203 fibrinogen beta chain Homo sapiens 68-78 3018111-12 1986 We conclude that uremia impairs the exposure of fibrinogen receptors on platelets in response to ADP or collagen without affecting the glycoprotein IIb-IIa complex quantitatively. Adenosine Diphosphate 97-100 fibrinogen beta chain Homo sapiens 48-58 3018111-13 1986 Correction by arachidonic acid of the impaired aggregation and exposure of fibrinogen receptors by ADP or collagen suggests that abnormal release of endogenous arachidonic acid plays a role in the dysfunction of platelets in uremia. Arachidonic Acid 14-30 fibrinogen beta chain Homo sapiens 75-85 3018111-13 1986 Correction by arachidonic acid of the impaired aggregation and exposure of fibrinogen receptors by ADP or collagen suggests that abnormal release of endogenous arachidonic acid plays a role in the dysfunction of platelets in uremia. Adenosine Diphosphate 99-102 fibrinogen beta chain Homo sapiens 75-85 3018111-13 1986 Correction by arachidonic acid of the impaired aggregation and exposure of fibrinogen receptors by ADP or collagen suggests that abnormal release of endogenous arachidonic acid plays a role in the dysfunction of platelets in uremia. Arachidonic Acid 160-176 fibrinogen beta chain Homo sapiens 75-85 3018735-3 1986 The mitogenic fibrinogen receptor is not recognized by antibodies specific for the platelet fibrinogen receptor or is not competitively blocked by synthetic peptides containing the Arg-Gly-Asp sequence, which is common to fibronectin, fibrinogen, vitronectin, and other cell-attachment proteins. Glycine 185-188 fibrinogen beta chain Homo sapiens 14-24 3018735-3 1986 The mitogenic fibrinogen receptor is not recognized by antibodies specific for the platelet fibrinogen receptor or is not competitively blocked by synthetic peptides containing the Arg-Gly-Asp sequence, which is common to fibronectin, fibrinogen, vitronectin, and other cell-attachment proteins. Aspartic Acid 189-192 fibrinogen beta chain Homo sapiens 14-24 3015954-1 1986 Platelet-activating factor 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF-acether) triggers exposure of fibrinogen binding sites on platelets via binding to specific receptors. o-alkyl-2-acetyl-sn-glycero-3-phosphocholine 29-73 fibrinogen beta chain Homo sapiens 109-119 3015954-1 1986 Platelet-activating factor 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF-acether) triggers exposure of fibrinogen binding sites on platelets via binding to specific receptors. Platelet Activating Factor 75-86 fibrinogen beta chain Homo sapiens 109-119 3015954-2 1986 Comparison of [3H]PAF-acether binding with 125I-fibrinogen binding shows that the rate with which PAF-acether binds to a number of receptors and not the degree of receptor occupancy determines how much fibrinogen binds. Platelet Activating Factor 98-109 fibrinogen beta chain Homo sapiens 202-212 3015954-8 1986 At 500 nM PAF-acether, this disappearance is exponential in nature and shows the same characteristics after 5-15 min incubation with fibrinogen as after 60 min. Platelet Activating Factor 10-21 fibrinogen beta chain Homo sapiens 133-143 3015954-10 1986 At 0.5 nM PAF-acether, the same characteristics are found after 60 min incubation with fibrinogen, but shorter incubation times reveal an ongoing binding site exposure that interferes with the disappearance process. Platelet Activating Factor 10-21 fibrinogen beta chain Homo sapiens 87-97 3743572-6 1986 Binding was specific for fibrinogen, was not observed with thrombasthenic platelets and was dependent upon the presence of extracellular calcium. Calcium 137-144 fibrinogen beta chain Homo sapiens 25-35 3095944-5 1986 Mean fibrinogen levels at the end of the infusions of 40 mg or 60 mg rt-PA over 90 min, measured in thawed plasma samples collected on citrate/aprotinin, decreased to 74% and 57% of the preinfusion values respectively. rt-pa 69-74 fibrinogen beta chain Homo sapiens 5-15 3095944-5 1986 Mean fibrinogen levels at the end of the infusions of 40 mg or 60 mg rt-PA over 90 min, measured in thawed plasma samples collected on citrate/aprotinin, decreased to 74% and 57% of the preinfusion values respectively. Citric Acid 135-142 fibrinogen beta chain Homo sapiens 5-15 3089297-8 1986 The increased protein phosphorylation and phosphatidic acid accumulation and the faster binding of PAF-acether to its receptors which accompany the better aggregation responses at 22 degrees C suggest that these processes are involved in the regulation of exposure of fibrinogen binding sites. Phosphatidic Acids 42-59 fibrinogen beta chain Homo sapiens 268-278 3015284-3 1986 Complete inhibition of ADP-induced aggregation was achieved five minutes after platelet exposure to 0.10 to 0.25 mmol/L of DB when fibrinogen binding was reduced by 50%. Adenosine Diphosphate 23-26 fibrinogen beta chain Homo sapiens 131-141 3728455-5 1986 Radioimmunoassay for FPA indicates that thrombin activation of fibrinogen is decreased by Zn(II), with 50% inhibition of FPA release observed at 35 microM Zn(II). Zinc 90-92 fibrinogen beta chain Homo sapiens 63-73 3728455-5 1986 Radioimmunoassay for FPA indicates that thrombin activation of fibrinogen is decreased by Zn(II), with 50% inhibition of FPA release observed at 35 microM Zn(II). Zinc 155-157 fibrinogen beta chain Homo sapiens 63-73 3015284-3 1986 Complete inhibition of ADP-induced aggregation was achieved five minutes after platelet exposure to 0.10 to 0.25 mmol/L of DB when fibrinogen binding was reduced by 50%. Dibucaine 123-125 fibrinogen beta chain Homo sapiens 131-141 3015284-4 1986 At higher concentrations of DB (approximately 1 mmol/L), ADP-induced fibrinogen binding was completely blocked. Dibucaine 28-30 fibrinogen beta chain Homo sapiens 69-79 3015284-4 1986 At higher concentrations of DB (approximately 1 mmol/L), ADP-induced fibrinogen binding was completely blocked. Adenosine Diphosphate 57-60 fibrinogen beta chain Homo sapiens 69-79 3015284-7 1986 Fibrinogen binding to chymotrypsin-treated platelets could not be completely inhibited even at high DB concentrations (1 mmol/L). Dibucaine 100-102 fibrinogen beta chain Homo sapiens 0-10 3730606-1 1986 Platelet activation by polymer surfaces is thought to require preliminary adsorption of fibrinogen and perhaps changes in fibrinogen conformation. Polymers 23-30 fibrinogen beta chain Homo sapiens 88-98 3730606-1 1986 Platelet activation by polymer surfaces is thought to require preliminary adsorption of fibrinogen and perhaps changes in fibrinogen conformation. Polymers 23-30 fibrinogen beta chain Homo sapiens 122-132 3015284-11 1986 Thus, exposure of platelets to DB results in membrane-related alterations that may contribute to inhibition of platelet cohesion: Decreased fibrinogen receptor exposure by traditional agonists and diminished accessibility of the GPIIb-IIIa complex to extracellular ligands correlate with DB-induced inhibition of platelet aggregation; and increased calcium uptake and exchange across the platelet membrane likely leads to activation of the calcium-dependent protease(s) which was previously shown to correlate with DB-induced inhibition of ristocetin-induced platelet agglutination. Dibucaine 31-33 fibrinogen beta chain Homo sapiens 140-150 3730606-5 1986 Tests of platelet retention and fibrinogen binding to four polyalkyl acrylates and to three unrelated polymers (polystyrene, polymethyl methacrylate, and a polyether polyurethane) indicated that platelet retention correlated positively with both total fibrinogen binding and with the amount of antibody-recognizable fibrinogen bound. Polymers 102-110 fibrinogen beta chain Homo sapiens 32-42 3730606-3 1986 For polyalkyl methacrylates with 1 to 4 carbon side chains, platelet reactivity varied directly with increasing length of the alkyl side chain and with the quantity of bound fibrinogen recognizable by antifibrinogen antibody but not with the total quantity of fibrinogen adsorbed. polyalkyl methacrylates 4-27 fibrinogen beta chain Homo sapiens 174-184 3730606-3 1986 For polyalkyl methacrylates with 1 to 4 carbon side chains, platelet reactivity varied directly with increasing length of the alkyl side chain and with the quantity of bound fibrinogen recognizable by antifibrinogen antibody but not with the total quantity of fibrinogen adsorbed. polyalkyl methacrylates 4-27 fibrinogen beta chain Homo sapiens 205-215 3730606-5 1986 Tests of platelet retention and fibrinogen binding to four polyalkyl acrylates and to three unrelated polymers (polystyrene, polymethyl methacrylate, and a polyether polyurethane) indicated that platelet retention correlated positively with both total fibrinogen binding and with the amount of antibody-recognizable fibrinogen bound. polyalkyl acrylates 59-78 fibrinogen beta chain Homo sapiens 32-42 3730607-6 1986 Fibrinogen complexes crosslinked with dimethylsuberimidate or Factor XIII neither aggregated gel-filtered platelets nor inhibited platelet aggregation by ADP and fibrinogen, probably because of inaccessibility of lysine residues in the D (terminal) domain of fibrinogen, which are thought to be required for platelet binding. Dimethyl Suberimidate 38-58 fibrinogen beta chain Homo sapiens 0-10 3016716-2 1986 The concentration of each peptide that inhibits 50% of 125I-labeled fibrinogen binding to thrombin-stimulated platelets (IC50) was then determined. Iodine-125 55-59 fibrinogen beta chain Homo sapiens 68-78 3016716-1 1986 We have constructed synthetic peptides modeled on the sequences of (i) Arg-Gly-Asp, present in fibrinogen, fibronectin, and von Willebrand factor, and of (ii) the fibrinogen gamma chain (gamma 400-411) His-His-Leu-Gly-Gly-Ala-Lys-Gln-Ala-Gly-Asp-Val. Aspartic Acid 79-82 fibrinogen beta chain Homo sapiens 95-105 3738860-1 1986 When human citrated plasma is dialysed against a phosphate buffer containing Ca++, citrate anions are removed, thrombin is generated and soluble fibrinogen derivatives (fibrin monomers and/or soluble fibrin polymers) are formed. Citric Acid 11-18 fibrinogen beta chain Homo sapiens 145-155 2941443-2 1986 Platelet membrane glycoproteins (GP) IIb and IIIa constitute a receptor for fibrinogen that, together with fibrinogen and calcium, is largely responsible for mediating the formation of the primary hemostatic plug. Calcium 122-129 fibrinogen beta chain Homo sapiens 76-86 2437513-1 1986 A simple method of concentrating a patient"s own fibrinogen for use with a thrombin/calcium solution--to produce a coagulum-type tissue glue for otologic surgery--is presented. Calcium 84-91 fibrinogen beta chain Homo sapiens 49-59 3739028-0 1986 [Mechanism of functioning of specific sites of interdomain D-E binding of fibrin molecules: interaction of fibrinogen with the N-terminal disulfide node of fibrin]. Disulfides 138-147 fibrinogen beta chain Homo sapiens 107-117 3708159-7 1986 An abnormal peptide was isolated after cyanogen bromide cleavage of intact fibrinogen Milano l. This fragment spans from position gamma 311 to gamma 336. Cyanogen Bromide 39-55 fibrinogen beta chain Homo sapiens 75-85 3087353-3 1986 Chondroitin sulphate E was observed to prolong the thrombin clotting time of fibrinogen in the absence of antithrombin III and heparin cofactor II. chondroitin sulphate e 0-22 fibrinogen beta chain Homo sapiens 77-87 3715811-0 1986 Binding properties on Sepharose insolubilized fibrinogen and fibrin, of various species of fibrinogen and fibrin solubilized in plasma. Sepharose 22-31 fibrinogen beta chain Homo sapiens 46-56 3715811-0 1986 Binding properties on Sepharose insolubilized fibrinogen and fibrin, of various species of fibrinogen and fibrin solubilized in plasma. Sepharose 22-31 fibrinogen beta chain Homo sapiens 91-101 3715811-6 1986 Sepharose insolubilized fibrinogen favoured the adsorption of soluble fibrins as compared to fibrinogen in solution; the adsorption of soluble des-AA fibrin was similar to that of soluble des-AABB fibrin. Sepharose 0-9 fibrinogen beta chain Homo sapiens 24-34 3083893-2 1986 A linear correlation (P less than .001) was found between the extent of fibrinogen breakdown and the amount of fibrin (0 to 32 mg/kg) injected just prior to the IV infusion of rt-PA at a rate of 10 micrograms/kg/min for 60 minutes. rt-pa 176-181 fibrinogen beta chain Homo sapiens 72-82 3012818-4 1986 Established ADP-induced aggregation was reversed by bimane, and fibrinogen binding to ADP-stimulated platelets was inhibited, an effect mainly due to decreased number of binding sites. Adenosine Diphosphate 12-15 fibrinogen beta chain Homo sapiens 64-74 3697510-0 1986 Fibrinopeptide A and the phosphate content of fibrinogen in venous thromboembolism and disseminated intravascular coagulation. Phosphates 25-34 fibrinogen beta chain Homo sapiens 46-56 3697510-8 1986 Phosphorus in fibrinogen did not correlate with fibrinogen degradation products or fibrinogen levels and became normal on adequate anticoagulation. Phosphorus 0-10 fibrinogen beta chain Homo sapiens 14-24 3697510-9 1986 Therefore, blood-clotting activation may lead to a high phosphate content of fibrinogen and of free FPA in plasma. Phosphates 56-65 fibrinogen beta chain Homo sapiens 77-87 3012818-4 1986 Established ADP-induced aggregation was reversed by bimane, and fibrinogen binding to ADP-stimulated platelets was inhibited, an effect mainly due to decreased number of binding sites. Adenosine Diphosphate 86-89 fibrinogen beta chain Homo sapiens 64-74 3010580-2 1986 Previous studies suggested a role for prostaglandins and/or thromboxane A2 in the exposure of fibrinogen receptors on platelets. Prostaglandins 38-52 fibrinogen beta chain Homo sapiens 94-104 2938632-9 1986 In order to study the effect of polymerization, this has been inhibited by the synthetic polymerization site analogue Gly-Pro-Arg-Pro, by fibrinogen fragment D1 or by prior methylene blue-dependent photooxidation of the fibrinogen used. Methylene Blue 173-187 fibrinogen beta chain Homo sapiens 220-230 2938632-10 1986 Inhibition of polymerization by Gly-Pro-Arg-Pro reduces plasmin generation to the low rate observed in the presence of fibrinogen. glycyl-prolyl-arginine 32-43 fibrinogen beta chain Homo sapiens 119-129 3711192-1 1986 The competitive adsorption of human serum albumin (HSA), human immuno-gamma-globulin (HIgG) and human fibrinogen (HFb) onto polystyrene (PS) at 20 degrees C and a pH of 7.35 (phosphate-buffered saline) was studied. Polystyrenes 124-135 fibrinogen beta chain Homo sapiens 102-112 3010580-4 1986 The present study compares fibrinogen binding to hyperaggregable platelets from diabetic patients and to normal platelets when prostaglandin/thromboxane formation is suppressed by aspirin. prostaglandin/thromboxane 127-152 fibrinogen beta chain Homo sapiens 27-37 3010580-4 1986 The present study compares fibrinogen binding to hyperaggregable platelets from diabetic patients and to normal platelets when prostaglandin/thromboxane formation is suppressed by aspirin. Aspirin 180-187 fibrinogen beta chain Homo sapiens 27-37 3010580-9 1986 We conclude that increased fibrinogen binding and hyperaggregability of platelets from non-retinopathic diabetics is related to their capacity to form more prostaglandin endoperoxides/thromboxane than normal platelets. Prostaglandin Endoperoxides 156-183 fibrinogen beta chain Homo sapiens 27-37 3010580-9 1986 We conclude that increased fibrinogen binding and hyperaggregability of platelets from non-retinopathic diabetics is related to their capacity to form more prostaglandin endoperoxides/thromboxane than normal platelets. Thromboxanes 184-195 fibrinogen beta chain Homo sapiens 27-37 3008579-1 1986 Stimulation of intact platelets by ADP results in a shape change followed by aggregation in the presence of fibrinogen. Adenosine Diphosphate 35-38 fibrinogen beta chain Homo sapiens 108-118 3963947-6 1986 We conclude that bleeding is related to the anticoagulant effects of fibrinogen degradation products interacting with heparin, and may be largely independent of hypofibrinogenemia. Heparin 118-125 fibrinogen beta chain Homo sapiens 69-79 3720040-0 1986 Heparin effect on plasma fibrinogen in the thrombophilic syndrome. Heparin 0-7 fibrinogen beta chain Homo sapiens 25-35 3008579-5 1986 On the other hand, the aggregation of chymotrypsin-treated platelets by fibrinogen was not dependent on the presence of ADP and could not be blocked by forskolin, prostaglandin E1, or prostacyclin, even though the levels of cyclic AMP (cAMP) formed in chymotrypsin-treated platelets were comparable to levels that completely inhibited the ADP-induced aggregation of intact platelets. Alprostadil 163-179 fibrinogen beta chain Homo sapiens 72-82 3008579-5 1986 On the other hand, the aggregation of chymotrypsin-treated platelets by fibrinogen was not dependent on the presence of ADP and could not be blocked by forskolin, prostaglandin E1, or prostacyclin, even though the levels of cyclic AMP (cAMP) formed in chymotrypsin-treated platelets were comparable to levels that completely inhibited the ADP-induced aggregation of intact platelets. Cyclic AMP 224-234 fibrinogen beta chain Homo sapiens 72-82 3008579-5 1986 On the other hand, the aggregation of chymotrypsin-treated platelets by fibrinogen was not dependent on the presence of ADP and could not be blocked by forskolin, prostaglandin E1, or prostacyclin, even though the levels of cyclic AMP (cAMP) formed in chymotrypsin-treated platelets were comparable to levels that completely inhibited the ADP-induced aggregation of intact platelets. Cyclic AMP 236-240 fibrinogen beta chain Homo sapiens 72-82 3008579-5 1986 On the other hand, the aggregation of chymotrypsin-treated platelets by fibrinogen was not dependent on the presence of ADP and could not be blocked by forskolin, prostaglandin E1, or prostacyclin, even though the levels of cyclic AMP (cAMP) formed in chymotrypsin-treated platelets were comparable to levels that completely inhibited the ADP-induced aggregation of intact platelets. Adenosine Diphosphate 339-342 fibrinogen beta chain Homo sapiens 72-82 3013157-1 1986 Casein kinase 2 from rat liver cytosol phosphorylated human fibrinogen in a reaction that was not stimulated by Ca2+ or cyclic AMP, but was markedly inhibited by heparin, and proceeded at a similar rate when either ATP or GTP was used as phosphate donor. Heparin 162-169 fibrinogen beta chain Homo sapiens 60-70 2420006-2 1986 The binding of both of these proteins to platelets is inhibited by synthetic peptides containing the sequence Arg-Gly-Asp, which corresponds to the cell adhesion site in fibronectin and is also present in the alpha chain of fibrinogen. Peptides 77-85 fibrinogen beta chain Homo sapiens 224-234 2420006-2 1986 The binding of both of these proteins to platelets is inhibited by synthetic peptides containing the sequence Arg-Gly-Asp, which corresponds to the cell adhesion site in fibronectin and is also present in the alpha chain of fibrinogen. Arginine 110-113 fibrinogen beta chain Homo sapiens 224-234 2420006-2 1986 The binding of both of these proteins to platelets is inhibited by synthetic peptides containing the sequence Arg-Gly-Asp, which corresponds to the cell adhesion site in fibronectin and is also present in the alpha chain of fibrinogen. Glycine 114-117 fibrinogen beta chain Homo sapiens 224-234 2420006-2 1986 The binding of both of these proteins to platelets is inhibited by synthetic peptides containing the sequence Arg-Gly-Asp, which corresponds to the cell adhesion site in fibronectin and is also present in the alpha chain of fibrinogen. Aspartic Acid 118-121 fibrinogen beta chain Homo sapiens 224-234 3514210-1 1986 Analysis by electrophoresis in sodium dodecyl sulphate/polyacrylamide gels co-polymerized with fibrinogen. Sodium Dodecyl Sulfate 31-54 fibrinogen beta chain Homo sapiens 95-105 3514210-1 1986 Analysis by electrophoresis in sodium dodecyl sulphate/polyacrylamide gels co-polymerized with fibrinogen. polyacrylamide 55-69 fibrinogen beta chain Homo sapiens 95-105 3956500-4 1986 At any fibrin concentration, 125I-fibrin sedimented faster than 131I-fibrinogen through 5-30% (w/v) sucrose gradients. Sucrose 100-107 fibrinogen beta chain Homo sapiens 69-79 3081373-0 1986 Plasminogen-binding site of the thermostable region of fibrinogen fragment D. Affinity chromatography of plasminogen and its proteolytic fragments on immobilized fibrinogen TSD fragment has shown that the latter contains a plasminogen-binding site which is complementary to the lysine-binding site(s) of plasminogen molecule 1-3 kringle structures. Lysine 278-284 fibrinogen beta chain Homo sapiens 55-65 3013157-1 1986 Casein kinase 2 from rat liver cytosol phosphorylated human fibrinogen in a reaction that was not stimulated by Ca2+ or cyclic AMP, but was markedly inhibited by heparin, and proceeded at a similar rate when either ATP or GTP was used as phosphate donor. Adenosine Triphosphate 215-218 fibrinogen beta chain Homo sapiens 60-70 3013157-1 1986 Casein kinase 2 from rat liver cytosol phosphorylated human fibrinogen in a reaction that was not stimulated by Ca2+ or cyclic AMP, but was markedly inhibited by heparin, and proceeded at a similar rate when either ATP or GTP was used as phosphate donor. Guanosine Triphosphate 222-225 fibrinogen beta chain Homo sapiens 60-70 3954674-4 1986 In response to ADP, collagen, or thrombin, FH platelets bound about twice as much 125I-fibrinogen as controls. Adenosine Diphosphate 15-18 fibrinogen beta chain Homo sapiens 87-97 3013157-1 1986 Casein kinase 2 from rat liver cytosol phosphorylated human fibrinogen in a reaction that was not stimulated by Ca2+ or cyclic AMP, but was markedly inhibited by heparin, and proceeded at a similar rate when either ATP or GTP was used as phosphate donor. Phosphates 238-247 fibrinogen beta chain Homo sapiens 60-70 3013157-2 1986 Analysis of casein kinase 2 by glycerol-density-gradient centrifugation showed that the activities towards fibrinogen, casein, phosvitin, high-mobility-group protein 14 and glycogen synthase coincided. Glycerol 31-39 fibrinogen beta chain Homo sapiens 107-117 3013157-3 1986 Maximal incorporation into fibrinogen by casein kinase 2 averaged 1 mol of phosphate/mol of protein substrate, most of it in the alpha-chain, although some phosphorylation of the beta-chain was also detected. Phosphates 75-84 fibrinogen beta chain Homo sapiens 27-37 3080261-10 1986 Administration of rt-PA resulted in a significant decline in fibrinogen and plasminogen while amounts of fibrin(ogen) degradation products rose. rt-pa 18-23 fibrinogen beta chain Homo sapiens 61-71 3005363-3 1986 Binding of radiolabeled fibrinogen to elastase-treated platelets was specific, saturable, and showed a single class of 48,400 +/- 9,697 fibrinogen-binding sites per platelet with a dissociation constant of 6.30 +/- 1.48 X 10(-7) M. ATP, apyrase, and the stimulators of platelet adenylate cyclase forskolin, prostaglandin E1, prostacyclin, and N6, 2"-O-dibutyryl cyclic AMP did not inhibit the fibrinogen-induced aggregation of elastase-treated platelets. Adenosine Triphosphate 232-235 fibrinogen beta chain Homo sapiens 24-34 3005363-3 1986 Binding of radiolabeled fibrinogen to elastase-treated platelets was specific, saturable, and showed a single class of 48,400 +/- 9,697 fibrinogen-binding sites per platelet with a dissociation constant of 6.30 +/- 1.48 X 10(-7) M. ATP, apyrase, and the stimulators of platelet adenylate cyclase forskolin, prostaglandin E1, prostacyclin, and N6, 2"-O-dibutyryl cyclic AMP did not inhibit the fibrinogen-induced aggregation of elastase-treated platelets. Colforsin 296-305 fibrinogen beta chain Homo sapiens 24-34 3005363-3 1986 Binding of radiolabeled fibrinogen to elastase-treated platelets was specific, saturable, and showed a single class of 48,400 +/- 9,697 fibrinogen-binding sites per platelet with a dissociation constant of 6.30 +/- 1.48 X 10(-7) M. ATP, apyrase, and the stimulators of platelet adenylate cyclase forskolin, prostaglandin E1, prostacyclin, and N6, 2"-O-dibutyryl cyclic AMP did not inhibit the fibrinogen-induced aggregation of elastase-treated platelets. Alprostadil 307-323 fibrinogen beta chain Homo sapiens 24-34 3005363-3 1986 Binding of radiolabeled fibrinogen to elastase-treated platelets was specific, saturable, and showed a single class of 48,400 +/- 9,697 fibrinogen-binding sites per platelet with a dissociation constant of 6.30 +/- 1.48 X 10(-7) M. ATP, apyrase, and the stimulators of platelet adenylate cyclase forskolin, prostaglandin E1, prostacyclin, and N6, 2"-O-dibutyryl cyclic AMP did not inhibit the fibrinogen-induced aggregation of elastase-treated platelets. Epoprostenol 325-337 fibrinogen beta chain Homo sapiens 24-34 3005363-3 1986 Binding of radiolabeled fibrinogen to elastase-treated platelets was specific, saturable, and showed a single class of 48,400 +/- 9,697 fibrinogen-binding sites per platelet with a dissociation constant of 6.30 +/- 1.48 X 10(-7) M. ATP, apyrase, and the stimulators of platelet adenylate cyclase forskolin, prostaglandin E1, prostacyclin, and N6, 2"-O-dibutyryl cyclic AMP did not inhibit the fibrinogen-induced aggregation of elastase-treated platelets. Bucladesine 343-372 fibrinogen beta chain Homo sapiens 24-34 3005363-4 1986 EDTA completely blocked the initiation of aggregation and reversed the fibrinogen-induced aggregation of elastase-treated platelets. Edetic Acid 0-4 fibrinogen beta chain Homo sapiens 71-81 3509954-0 1986 [Effect of peptides--structural analogs of NH2-terminal sites of fibrin alpha- and beta-chains--on specific binding of the NH2-terminal disulfide bond of fibrin with fibrinogen]. Disulfides 136-145 fibrinogen beta chain Homo sapiens 166-176 3705201-3 1986 A shape of the concentration dependence curve of the inhibitory effect of tetrapeptide Gly-Pro-Arg-Pro on the polymerization of both fibrin types is similar to the previously found curve for fibrinogen and its fragments--specific inhibitors of polymerization. glycyl-prolyl-arginyl-proline 87-102 fibrinogen beta chain Homo sapiens 191-201 3942829-5 1986 The latter fibrinogen was 50% less effective than F gamma 50 in supporting ADP-induced platelet aggregation at concentrations of .01 to 2 mg/mL. Adenosine Diphosphate 75-78 fibrinogen beta chain Homo sapiens 11-21 3943666-6 1986 However, while aspirin (an inhibitor of thromboxane synthesis) reduced the abnormally high fibrinogen binding of platelets from nonretinopathic patients to normal control levels, it did not normalize the high fibrinogen binding of platelets from retinopathic diabetic patients. Aspirin 15-22 fibrinogen beta chain Homo sapiens 91-101 3943666-7 1986 The combination of aspirin plus apyrase (an ADP scavenger) almost suppressed fibrinogen binding and aggregation of platelets from normal or nonretinopathic diabetic subjects, whereas it had a somewhat lesser effect on binding and aggregation of platelets from retinopathic subjects. Aspirin 19-26 fibrinogen beta chain Homo sapiens 77-87 3456154-0 1986 Distinctive role of histidine-16 of the B beta chain of fibrinogen in the end-to-end association of fibrin. Histidine 20-29 fibrinogen beta chain Homo sapiens 56-66 3456154-2 1986 The fibrin fragment des-AB N-DSK, which contains the binding sites termed A and B, lost the ability to bind to the site termed a in fibrinogen-Sepharose upon the oxidation of histidine-16 in the B beta chain of fibrinogen [Shimizu, A., Saito, Y., Matsushima, A. Sepharose 143-152 fibrinogen beta chain Homo sapiens 132-142 3456154-2 1986 The fibrin fragment des-AB N-DSK, which contains the binding sites termed A and B, lost the ability to bind to the site termed a in fibrinogen-Sepharose upon the oxidation of histidine-16 in the B beta chain of fibrinogen [Shimizu, A., Saito, Y., Matsushima, A. Sepharose 143-152 fibrinogen beta chain Homo sapiens 211-221 3456154-2 1986 The fibrin fragment des-AB N-DSK, which contains the binding sites termed A and B, lost the ability to bind to the site termed a in fibrinogen-Sepharose upon the oxidation of histidine-16 in the B beta chain of fibrinogen [Shimizu, A., Saito, Y., Matsushima, A. histidine-16 175-187 fibrinogen beta chain Homo sapiens 132-142 3456154-2 1986 The fibrin fragment des-AB N-DSK, which contains the binding sites termed A and B, lost the ability to bind to the site termed a in fibrinogen-Sepharose upon the oxidation of histidine-16 in the B beta chain of fibrinogen [Shimizu, A., Saito, Y., Matsushima, A. histidine-16 175-187 fibrinogen beta chain Homo sapiens 211-221 3456154-7 1986 Some of the fragments, which became unable to bind to fibrinogen-Sepharose due to the destruction of site A, however, retained the ability to bind to D-dimer-Sepharose, which contains both sites a and b. Sepharose 65-74 fibrinogen beta chain Homo sapiens 54-64 2433859-2 1986 Fab fragments prepared from anti FgD antisera were the most efficient inhibitors of thrombin-catalysed conversion of fibrinogen to fibrin; polymerization of fibrin monomers as detected spectrophotometrically was abolished at 2:1 molar ratio of anti FgD Fab fragments to fibra monomer. fibra 270-275 fibrinogen beta chain Homo sapiens 117-127 3456154-8 1986 This shows that histidine-16 of the B beta chain of fibrinogen is essential for site A but may not be essential for site B. Histidine 16-25 fibrinogen beta chain Homo sapiens 52-62 3010440-3 1986 Fibrinogen Oslo I acted more efficiently in ADP-induced platelet aggregation, and bound to gel-filtered platelets with a higher affinity constant than did normal fibrinogen. Adenosine Diphosphate 44-47 fibrinogen beta chain Homo sapiens 0-10 2418738-4 1986 The fibrinogen and factor XIII component of the adhesive was isolated by polyethylene glycol precipitation from human plasma within a few hours, and was used either immediately or frozen for use up to 3 weeks later. Polyethylene Glycols 73-92 fibrinogen beta chain Homo sapiens 4-14 3531894-0 1986 The effect of fibrinogen-methotrexate derivatives on HeLa cell growth. Methotrexate 25-37 fibrinogen beta chain Homo sapiens 14-24 3594000-5 1986 The enzyme hydrolyzes the alpha-chain of fibrinogen, has amidase activity on L-arginine-p-nitroanilide and L-arginine-7-amido-4-methyl-coumarin amino terminal blocked peptides and presents esterolytic activity on N-alpha-tosyl-L-arginine-methylester. l-arginine-p-nitroanilide 77-102 fibrinogen beta chain Homo sapiens 41-51 3594000-5 1986 The enzyme hydrolyzes the alpha-chain of fibrinogen, has amidase activity on L-arginine-p-nitroanilide and L-arginine-7-amido-4-methyl-coumarin amino terminal blocked peptides and presents esterolytic activity on N-alpha-tosyl-L-arginine-methylester. l-arginine-7-amido-4-methyl-coumarin 107-143 fibrinogen beta chain Homo sapiens 41-51 3779115-3 1986 Binding assays were performed on PBMC using 125I-labeled fibrinogen complexed with rabbit IgG (or as a control F(ab")2) anti-human fibrinogen. Iodine-125 44-48 fibrinogen beta chain Homo sapiens 57-67 2935559-3 1986 In addition, the paraprotein inhibited adhesion to glass microbeads, fibrin clot retraction, and binding of radiolabeled fibrinogen or von Willebrand factor to platelets exposed to thrombin or arachidonic acid without affecting intraplatelet levels of cAMP. Arachidonic Acid 193-209 fibrinogen beta chain Homo sapiens 121-131 2935559-3 1986 In addition, the paraprotein inhibited adhesion to glass microbeads, fibrin clot retraction, and binding of radiolabeled fibrinogen or von Willebrand factor to platelets exposed to thrombin or arachidonic acid without affecting intraplatelet levels of cAMP. Cyclic AMP 252-256 fibrinogen beta chain Homo sapiens 121-131 3531894-1 1986 Proteolytic cleavage of bovine fibrinogen with covalently bound methotrexate (MTX) was studied using four different proteolytic enzymes--trypsin, chymotrypsin, pepsin, and cathepsin D and the interaction of the modified fibrinogen (or fibrin) with HeLa cells was investigated. Methotrexate 78-81 fibrinogen beta chain Homo sapiens 31-41 3531894-1 1986 Proteolytic cleavage of bovine fibrinogen with covalently bound methotrexate (MTX) was studied using four different proteolytic enzymes--trypsin, chymotrypsin, pepsin, and cathepsin D and the interaction of the modified fibrinogen (or fibrin) with HeLa cells was investigated. Methotrexate 64-76 fibrinogen beta chain Homo sapiens 31-41 3834177-0 1985 [Localization of thrombi using the Ga-67-DFO-DAS fibrinogen]. Deferoxamine 41-44 fibrinogen beta chain Homo sapiens 49-59 3798336-5 1986 Fibrinogen (FG) is another main component of the heparin precipitate. Heparin 49-56 fibrinogen beta chain Homo sapiens 0-10 3798336-5 1986 Fibrinogen (FG) is another main component of the heparin precipitate. Heparin 49-56 fibrinogen beta chain Homo sapiens 12-14 3798336-6 1986 To determine the functional activity of plasma FN in sepsis and other pathological conditions, a study was made of the ability of FN and FG to go into the precipitate formed in blood plasma in the cold after its incubation with heparin. Heparin 228-235 fibrinogen beta chain Homo sapiens 137-139 3798336-7 1986 Unlike normal subjects in whom over 80% of FN on the average and about 20% of FG went into the heparin precipitate, in patients with hemoblastoses and aplastic anemia complicated by sepsis, less than 40% of FN on the average and about 7% of FG went into the precipitate. Heparin 95-102 fibrinogen beta chain Homo sapiens 78-80 3798336-10 1986 In uncomplicated hemoblastoses, cryoglobulinemia and cryofibrinogenemia and in immunocomplex pathology, the consumption of FN and FG during heparin precipitate formation did not significantly differ from the control. Heparin 140-147 fibrinogen beta chain Homo sapiens 130-132 3496699-0 1986 von Willebrand factor can substitute for plasma fibrinogen in ADP-induced platelet aggregation. Adenosine Diphosphate 62-65 fibrinogen beta chain Homo sapiens 48-58 3083587-1 1986 Fibrinogen attackability by digestive proteinases rises insignificantly after thermodenaturation and does not change after exposure to the denaturation action of urea. Urea 162-166 fibrinogen beta chain Homo sapiens 0-10 2868545-0 1985 Factor XIII catalyzed formation of fibrinogen-fibronectin oligomers--a thiol enhanced process. Sulfhydryl Compounds 71-76 fibrinogen beta chain Homo sapiens 35-45 2998483-0 1985 Lysine binding to activated human platelets and its similarity to fibrinogen binding. Lysine 0-6 fibrinogen beta chain Homo sapiens 66-76 2998483-2 1985 Fibrinogen binding is essential for platelet aggregation and several amines have been shown to inhibit this binding. Amines 69-75 fibrinogen beta chain Homo sapiens 0-10 2998483-3 1985 The present study compares the binding properties of 125I-fibrinogen and [3H]lysine with platelets activated by the Ca2+ ionophore A23187. Calcimycin 131-137 fibrinogen beta chain Homo sapiens 58-68 4093900-4 1985 In men with high cholesterol or high systolic blood pressure levels the incidence of heart attacks was respectively six times and 12 times greater in those with high plasma fibrinogen levels than in those with low fibrinogen levels. Cholesterol 17-28 fibrinogen beta chain Homo sapiens 173-183 4093900-4 1985 In men with high cholesterol or high systolic blood pressure levels the incidence of heart attacks was respectively six times and 12 times greater in those with high plasma fibrinogen levels than in those with low fibrinogen levels. Cholesterol 17-28 fibrinogen beta chain Homo sapiens 214-224 4093900-5 1985 In multivariate models plasma fibrinogen was a highly significant and independent explanatory variable, at least as important as serum cholesterol, blood pressure or cigarette smoking. Cholesterol 135-146 fibrinogen beta chain Homo sapiens 30-40 3877935-0 1985 The effect of Arg-Gly-Asp-containing peptides on fibrinogen and von Willebrand factor binding to platelets. Arginine 14-17 fibrinogen beta chain Homo sapiens 49-59 3877935-4 1985 Gly-Arg-Gly-Asp-Ser-Pro was used as a prototype peptide, and this hexapeptide inhibited fibrinogen binding to ADP and thrombin-stimulated platelets in the 10-200 microM range. glycyl-arginyl-glycyl-aspartyl-seryl-proline 0-23 fibrinogen beta chain Homo sapiens 88-98 3877935-4 1985 Gly-Arg-Gly-Asp-Ser-Pro was used as a prototype peptide, and this hexapeptide inhibited fibrinogen binding to ADP and thrombin-stimulated platelets in the 10-200 microM range. Adenosine Diphosphate 110-113 fibrinogen beta chain Homo sapiens 88-98 2937452-0 1986 Localization of segments essential for polymerization and for calcium binding in the gamma-chain of human fibrinogen. Calcium 62-69 fibrinogen beta chain Homo sapiens 106-116 2935535-3 1985 The fibrinogen was eluted sequentially, first by 1 M Tris and then by SDS. Tromethamine 53-57 fibrinogen beta chain Homo sapiens 4-14 2935535-3 1985 The fibrinogen was eluted sequentially, first by 1 M Tris and then by SDS. Sodium Dodecyl Sulfate 70-73 fibrinogen beta chain Homo sapiens 4-14 2935535-4 1985 The initially eluted fibrinogen showed considerable degradation (SDS polyacrylamide gel electrophoresis) while the later fractions were less degraded. Sodium Dodecyl Sulfate 65-68 fibrinogen beta chain Homo sapiens 21-31 2935535-4 1985 The initially eluted fibrinogen showed considerable degradation (SDS polyacrylamide gel electrophoresis) while the later fractions were less degraded. polyacrylamide 69-83 fibrinogen beta chain Homo sapiens 21-31 2935535-5 1985 Fibrinogen purified by chromatography on either DEAE-cellulose or Sepharose-lysine to remove plasminogen was less degraded. DEAE-Cellulose 48-62 fibrinogen beta chain Homo sapiens 0-10 2935535-5 1985 Fibrinogen purified by chromatography on either DEAE-cellulose or Sepharose-lysine to remove plasminogen was less degraded. sepharose-lysine 66-82 fibrinogen beta chain Homo sapiens 0-10 4057083-7 1985 Fibrinogen levels were measured by a clotting rate assay and by sodium sulfite precipitation. sodium sulfite 64-78 fibrinogen beta chain Homo sapiens 0-10 4057083-11 1985 Fibrinogen assays with the sodium sulfite method showed a much less extensive decrease of fibrinogen. sodium sulfite 27-41 fibrinogen beta chain Homo sapiens 0-10 4057083-11 1985 Fibrinogen assays with the sodium sulfite method showed a much less extensive decrease of fibrinogen. sodium sulfite 27-41 fibrinogen beta chain Homo sapiens 90-100 2932434-2 1985 This part of the molecule is retained on the gamma chain of fragment D (FgD) when fibrinogen is digested by plasmin in the presence of calcium to produce the fragment D-fragment E (FgD X FgE) complex but is lost if FgD is prepared in the absence of calcium. Calcium 135-142 fibrinogen beta chain Homo sapiens 82-92 2932434-2 1985 This part of the molecule is retained on the gamma chain of fragment D (FgD) when fibrinogen is digested by plasmin in the presence of calcium to produce the fragment D-fragment E (FgD X FgE) complex but is lost if FgD is prepared in the absence of calcium. Calcium 249-256 fibrinogen beta chain Homo sapiens 82-92 3937259-4 1985 When stimulated by arachidonic acid, the platelets released AT III antigen together with immunoreactive fibrinogen. Arachidonic Acid 19-35 fibrinogen beta chain Homo sapiens 104-114 3937270-2 1985 In a preceding paper the baseline data in the Munster Arteriosclerosis Study (PROCAM study) of the levels of fibrinogen, factor VIIc and factor VIIIc were described, and their correlation of age, body weight, smoking, alcohol, pill-using and menopause discussed. Alcohols 218-225 fibrinogen beta chain Homo sapiens 109-119 4082678-2 1985 Within the glycolysation reactions of the glucose with albumins it is especially being referred to the connection with haemoglobin, fibrinogen, albumin, kristallin, myelin, the membrane proteins and apoproteins and it is shortly being reported on the clinical effects. Glucose 42-49 fibrinogen beta chain Homo sapiens 132-142 2995350-4 1985 Moreover, the amino acid sequence Arg-Gly-Asp-Ser, corresponding to the cell attachment site of fibronectin, is located near the carboxyl-terminal region of the alpha-chain of fibrinogen. Arginine 34-37 fibrinogen beta chain Homo sapiens 176-186 2995350-4 1985 Moreover, the amino acid sequence Arg-Gly-Asp-Ser, corresponding to the cell attachment site of fibronectin, is located near the carboxyl-terminal region of the alpha-chain of fibrinogen. Glycine 38-41 fibrinogen beta chain Homo sapiens 176-186 2995350-4 1985 Moreover, the amino acid sequence Arg-Gly-Asp-Ser, corresponding to the cell attachment site of fibronectin, is located near the carboxyl-terminal region of the alpha-chain of fibrinogen. Aspartic Acid 42-45 fibrinogen beta chain Homo sapiens 176-186 2995350-4 1985 Moreover, the amino acid sequence Arg-Gly-Asp-Ser, corresponding to the cell attachment site of fibronectin, is located near the carboxyl-terminal region of the alpha-chain of fibrinogen. Serine 46-49 fibrinogen beta chain Homo sapiens 176-186 2995350-8 1985 Arg-Gly-Asp-Ser, but not Arg-Gly-Tyr-Ser-Leu-Gly, also inhibited fibrinogen binding to ADP-stimulated platelets. arginyl-glycyl-aspartyl-serine 0-15 fibrinogen beta chain Homo sapiens 65-75 2995350-8 1985 Arg-Gly-Asp-Ser, but not Arg-Gly-Tyr-Ser-Leu-Gly, also inhibited fibrinogen binding to ADP-stimulated platelets. Adenosine Diphosphate 87-90 fibrinogen beta chain Homo sapiens 65-75 2995350-9 1985 This inhibition was competitive with a Ki of approximately equal to 25 microM but was incomplete even at higher tetrapeptide concentrations, indicating that Arg-Gly-Asp-Ser is a partial competitive inhibitor of fibrinogen binding. arginyl-glycyl-aspartyl-serine 157-172 fibrinogen beta chain Homo sapiens 211-221 3930491-10 1985 TSP binding to fibrinogen-Sepharose occurred in the presence of EDTA, indicating that calcium and magnesium ions are not required for interaction of TSP with fibrinogen. Sepharose 26-35 fibrinogen beta chain Homo sapiens 15-25 4052633-7 1985 In the presence of calcium, fibrinogen at concentrations from 0 to 12 mumol/L reduced the rate of inhibition in a competitive manner, giving an apparent Kd for fibrinogen of 6.0 mumol/L. Calcium 19-26 fibrinogen beta chain Homo sapiens 28-38 4052633-7 1985 In the presence of calcium, fibrinogen at concentrations from 0 to 12 mumol/L reduced the rate of inhibition in a competitive manner, giving an apparent Kd for fibrinogen of 6.0 mumol/L. Calcium 19-26 fibrinogen beta chain Homo sapiens 160-170 2994782-4 1985 Upon thrombin or A23187 stimulation, TSP, fibrinogen, and GPIIb-IIIa colocalized on the platelet membrane and the canalicular system as well as on pseudopodia and between adherent platelets. Calcimycin 17-23 fibrinogen beta chain Homo sapiens 42-52 3876125-6 1985 Peptides containing the arg-gly-asp-ser sequence were also capable of inhibiting the adhesion of platelets to fibrinogen and von Willebrand factor substrates. Arginine 24-27 fibrinogen beta chain Homo sapiens 110-120 3876125-6 1985 Peptides containing the arg-gly-asp-ser sequence were also capable of inhibiting the adhesion of platelets to fibrinogen and von Willebrand factor substrates. Glycine 28-31 fibrinogen beta chain Homo sapiens 110-120 3876125-6 1985 Peptides containing the arg-gly-asp-ser sequence were also capable of inhibiting the adhesion of platelets to fibrinogen and von Willebrand factor substrates. Aspartic Acid 32-35 fibrinogen beta chain Homo sapiens 110-120 3876125-6 1985 Peptides containing the arg-gly-asp-ser sequence were also capable of inhibiting the adhesion of platelets to fibrinogen and von Willebrand factor substrates. Serine 36-39 fibrinogen beta chain Homo sapiens 110-120 3930491-11 1985 The binding of TSP to fibrinogen-Sepharose was quantitatively blocked by pretreatment with an antibody to the cyanogen bromide cleavage fragment composed of residues 241-476 of the carboxyl-terminal end of the alpha chain of fibrinogen. Sepharose 33-42 fibrinogen beta chain Homo sapiens 22-32 3930491-11 1985 The binding of TSP to fibrinogen-Sepharose was quantitatively blocked by pretreatment with an antibody to the cyanogen bromide cleavage fragment composed of residues 241-476 of the carboxyl-terminal end of the alpha chain of fibrinogen. Sepharose 33-42 fibrinogen beta chain Homo sapiens 225-235 3930491-11 1985 The binding of TSP to fibrinogen-Sepharose was quantitatively blocked by pretreatment with an antibody to the cyanogen bromide cleavage fragment composed of residues 241-476 of the carboxyl-terminal end of the alpha chain of fibrinogen. Cyanogen Bromide 110-126 fibrinogen beta chain Homo sapiens 22-32 3930491-11 1985 The binding of TSP to fibrinogen-Sepharose was quantitatively blocked by pretreatment with an antibody to the cyanogen bromide cleavage fragment composed of residues 241-476 of the carboxyl-terminal end of the alpha chain of fibrinogen. Cyanogen Bromide 110-126 fibrinogen beta chain Homo sapiens 225-235 3930491-13 1985 Excess fibrinogen (30 mg/ml) added to platelet extract quantitatively inhibited binding of TSP to fibrinogen-Sepharose. Sepharose 109-118 fibrinogen beta chain Homo sapiens 7-17 3930491-13 1985 Excess fibrinogen (30 mg/ml) added to platelet extract quantitatively inhibited binding of TSP to fibrinogen-Sepharose. Sepharose 109-118 fibrinogen beta chain Homo sapiens 98-108 4041619-2 1985 Fibrinogen was separated from other released proteins by chromatography on diethylaminoethanol (DEAE)-cellulose using a continuous pH and ionic strength gradient. diethylaminoethanol (deae)-cellulose 75-111 fibrinogen beta chain Homo sapiens 0-10 4041619-3 1985 Purified platelet fibrinogen, greater than 98% homogeneous by immunoelectrophoresis and sodium-dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), consisted of intact A alpha, B beta and gamma A chains, but not gamma" chains, and was 95% to 96% clottable. Sodium Dodecyl Sulfate 88-110 fibrinogen beta chain Homo sapiens 18-28 4041619-3 1985 Purified platelet fibrinogen, greater than 98% homogeneous by immunoelectrophoresis and sodium-dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), consisted of intact A alpha, B beta and gamma A chains, but not gamma" chains, and was 95% to 96% clottable. polyacrylamide 111-125 fibrinogen beta chain Homo sapiens 18-28 2998916-8 1985 In Crohn"s disease patients, copper serum concentration was increased and correlated positively to fibrinogen and C-reactive protein concentrations, erythrocyte sedimentation rate and thrombocytosis, and negatively to hematocrit. Copper 29-35 fibrinogen beta chain Homo sapiens 99-109 3902901-3 1985 Human fibrinogen induced platelet aggregation in 65% of platelet rich plasma samples and enhanced submaximal platelet aggregation induced by heparin or by several conventional agonists in all samples. Heparin 141-148 fibrinogen beta chain Homo sapiens 6-16 3902901-5 1985 Fibrinogen induced aggregation was associated with the release of the vasoconstrictor, thromboxane A2. Thromboxane A2 87-101 fibrinogen beta chain Homo sapiens 0-10 3161948-3 1985 Fibrinogen treated with tryptase together with heparin lost all detectable clotting activity by 4 hr at 37 degrees C, whereas fibrinogen treated with tryptase alone resulted in destruction of only 80% of fibrinogen clotting equivalents after 16 hr. Heparin 47-54 fibrinogen beta chain Homo sapiens 0-10 3161948-4 1985 Tryptase alone was observed to cleave only the alpha-chains of fibrinogen by electrophoresis of tryptase-treated, denatured, and reduced fibrinogen in polyacrylamide gradient gels. polyacrylamide 151-165 fibrinogen beta chain Homo sapiens 63-73 3161948-5 1985 Tryptase together with heparin cleaved first the alpha-chain and then the beta-chain, the latter cleavage corresponding to complete loss of fibrinogen clotting activity by 4 hr. Heparin 23-30 fibrinogen beta chain Homo sapiens 140-150 3161948-12 1985 by SDS polyacrylamide gel electrophoresis of unreduced fibrinogen is not appreciably altered by prior treatment with tryptase, even though cleavage of alpha-and beta-chains is revealed after reduction. Sodium Dodecyl Sulfate 3-6 fibrinogen beta chain Homo sapiens 55-65 3161948-12 1985 by SDS polyacrylamide gel electrophoresis of unreduced fibrinogen is not appreciably altered by prior treatment with tryptase, even though cleavage of alpha-and beta-chains is revealed after reduction. polyacrylamide 7-21 fibrinogen beta chain Homo sapiens 55-65 4089822-0 1985 Fibrinogen coagulation without thrombin: reaction with vitamin C and copper(II). Ascorbic Acid 55-64 fibrinogen beta chain Homo sapiens 0-10 4089822-0 1985 Fibrinogen coagulation without thrombin: reaction with vitamin C and copper(II). cupric ion 69-79 fibrinogen beta chain Homo sapiens 0-10 4089822-2 1985 The addition of vitamin C (0.1-1 mM) to a solution of fibrinogen (1 mg/ml) and Cu(II) (20-150 microM) results in protein coming out of solution. Ascorbic Acid 16-25 fibrinogen beta chain Homo sapiens 54-64 4089822-6 1985 Isoelectric focusing and SDS-electrophoretic comparison of native fibrinogen with neofibe reveal molecular modifications of the starting protein. Sodium Dodecyl Sulfate 25-28 fibrinogen beta chain Homo sapiens 66-76 2993278-4 1985 We examined the effects of leupeptin and antipain, two calcium-activated protease inhibitors, on the expression of platelet fibrinogen receptors. leupeptin 27-36 fibrinogen beta chain Homo sapiens 124-134 2993278-5 1985 These inhibitors abolished thrombin and ADP-induced fibrinogen binding. Adenosine Diphosphate 40-43 fibrinogen beta chain Homo sapiens 52-62 2993278-7 1985 Leupeptin and antipain also inhibited fibrinogen-independent thrombin-stimulated release of serotonin. Serotonin 92-101 fibrinogen beta chain Homo sapiens 38-48 2993285-7 1985 125I-Fibrinogen binding was inhibited by amino sugars, the GP IIb and/or IIIa monoclonal antibody 10E5, and the decapeptide from the carboxyl terminus of the fibrinogen gamma chain. Amino Sugars 41-53 fibrinogen beta chain Homo sapiens 5-15 4029510-7 1985 In type I diabetic patients with vascular complications, hyperglycemia induced by an oral glucose challenge was accompanied by elevation of plasma FPA and acceleration of fibrinogen disappearance. Glucose 90-97 fibrinogen beta chain Homo sapiens 171-181 4043093-0 1985 Fibrinogen distribution on surfaces and in organelles of ADP stimulated human blood platelets. Adenosine Diphosphate 57-60 fibrinogen beta chain Homo sapiens 0-10 4043093-1 1985 The fibrinogen distribution in platelet organelles after ADP-stimulation was investigated with anti-human fibrinogen using protein A-gold applied to serial sections. Adenosine Diphosphate 57-60 fibrinogen beta chain Homo sapiens 4-14 4043093-2 1985 Fibrinogen was detected in the so-called alpha-granules of platelets and also in granule protrusions which were observed after ADP-stimulation. Adenosine Diphosphate 127-130 fibrinogen beta chain Homo sapiens 0-10 4030100-1 1985 Immunochemically identical components were isolated from water-soluble phases of five Staphylococcus aureus strains by affinity chromatography on fibrinogen-linked Sepharose 4B. Sepharose 164-173 fibrinogen beta chain Homo sapiens 146-156 4077019-5 1985 The total content of sialic acid in purified abnormal fibrinogen was markedly increased as compared to that in purified normal fibrinogen. N-Acetylneuraminic Acid 21-32 fibrinogen beta chain Homo sapiens 54-64 4077019-8 1985 It was reported by Harvey (1978) that an abnormal fibrinogen in liver diseases was similar to the fetal fibrinogen in the content of sialic acid and prolongation of thrombin time. N-Acetylneuraminic Acid 133-144 fibrinogen beta chain Homo sapiens 50-60 4077019-8 1985 It was reported by Harvey (1978) that an abnormal fibrinogen in liver diseases was similar to the fetal fibrinogen in the content of sialic acid and prolongation of thrombin time. N-Acetylneuraminic Acid 133-144 fibrinogen beta chain Homo sapiens 104-114 3936222-0 1985 A rapid method for isolation of fibrinogen from human plasma by precipitation with polyethylene glycol 6,000. polyethylene glycol 6 83-104 fibrinogen beta chain Homo sapiens 32-42 3160702-0 1985 Localization of a fibrinogen calcium binding site between gamma-subunit positions 311 and 336 by terbium fluorescence. Calcium 29-36 fibrinogen beta chain Homo sapiens 18-28 3160702-0 1985 Localization of a fibrinogen calcium binding site between gamma-subunit positions 311 and 336 by terbium fluorescence. Terbium 97-104 fibrinogen beta chain Homo sapiens 18-28 3160702-3 1985 Terbium (Tb3+) competitively inhibited 45Ca2+ binding to fibrinogen during equilibrium dialysis, accelerated fibrin polymerization, and limited fibrinogen fragment D digestion by plasmin. Terbium 0-7 fibrinogen beta chain Homo sapiens 57-67 3160702-3 1985 Terbium (Tb3+) competitively inhibited 45Ca2+ binding to fibrinogen during equilibrium dialysis, accelerated fibrin polymerization, and limited fibrinogen fragment D digestion by plasmin. Terbium 0-7 fibrinogen beta chain Homo sapiens 144-154 3160702-3 1985 Terbium (Tb3+) competitively inhibited 45Ca2+ binding to fibrinogen during equilibrium dialysis, accelerated fibrin polymerization, and limited fibrinogen fragment D digestion by plasmin. tb3+ 9-13 fibrinogen beta chain Homo sapiens 57-67 3160702-3 1985 Terbium (Tb3+) competitively inhibited 45Ca2+ binding to fibrinogen during equilibrium dialysis, accelerated fibrin polymerization, and limited fibrinogen fragment D digestion by plasmin. tb3+ 9-13 fibrinogen beta chain Homo sapiens 144-154 3160702-4 1985 The intrinsic fluorescence of Ca2+-depleted fibrinogen was maximally enhanced by Ca2+ and Tb3+, but not by Mg2+, at about 3 mol of cation/mol of fibrinogen. tb3+ 90-94 fibrinogen beta chain Homo sapiens 44-54 3160702-4 1985 The intrinsic fluorescence of Ca2+-depleted fibrinogen was maximally enhanced by Ca2+ and Tb3+, but not by Mg2+, at about 3 mol of cation/mol of fibrinogen. magnesium ion 107-111 fibrinogen beta chain Homo sapiens 44-54 3160702-5 1985 Protein-bound Tb3+ fluorescence at 545 nm was maximally enhanced by resonance energy transfer from tryptophan (excitation at 290 nm) at about 2 mol of Tb3+mol of fibrinogen and about 1 mol of Tb3+/mol of plasmic fragment D94 (Mr 94,000). tb3+ 14-18 fibrinogen beta chain Homo sapiens 162-172 3160702-5 1985 Protein-bound Tb3+ fluorescence at 545 nm was maximally enhanced by resonance energy transfer from tryptophan (excitation at 290 nm) at about 2 mol of Tb3+mol of fibrinogen and about 1 mol of Tb3+/mol of plasmic fragment D94 (Mr 94,000). Tryptophan 99-109 fibrinogen beta chain Homo sapiens 162-172 3161453-1 1985 Human, dog, and rabbit fibrinogen served as substrates for calcium-activated, phospholipid-dependent protein kinase, cAMP-dependent protein kinase, casein kinase TS, and casein kinase S. The chains of phosphorylated fibrinogen were separated by polyacrylamide gel electrophoresis and the phosphorylation patterns, obtained on autoradiography of the gels, were found to be characteristic for each of the four protein kinases. Calcium 59-66 fibrinogen beta chain Homo sapiens 23-33 3161453-1 1985 Human, dog, and rabbit fibrinogen served as substrates for calcium-activated, phospholipid-dependent protein kinase, cAMP-dependent protein kinase, casein kinase TS, and casein kinase S. The chains of phosphorylated fibrinogen were separated by polyacrylamide gel electrophoresis and the phosphorylation patterns, obtained on autoradiography of the gels, were found to be characteristic for each of the four protein kinases. Cyclic AMP 117-121 fibrinogen beta chain Homo sapiens 23-33 3161453-1 1985 Human, dog, and rabbit fibrinogen served as substrates for calcium-activated, phospholipid-dependent protein kinase, cAMP-dependent protein kinase, casein kinase TS, and casein kinase S. The chains of phosphorylated fibrinogen were separated by polyacrylamide gel electrophoresis and the phosphorylation patterns, obtained on autoradiography of the gels, were found to be characteristic for each of the four protein kinases. polyacrylamide 245-259 fibrinogen beta chain Homo sapiens 23-33 4049325-0 1985 Evidence that changes in fibrinogen quality during acute phase reactions are of major importance for the amount of heparin precipitable fraction (HPF). Heparin 115-122 fibrinogen beta chain Homo sapiens 25-35 3875376-5 1985 Inhibitory antibodies were effective in the same dose range for all four proteins and also inhibited binding of fibrinogen, fibronectin, and von Willebrand factor to receptors fixed in an induced state (thrombin-stimulated platelets fixed with paraformaldehyde). paraform 244-260 fibrinogen beta chain Homo sapiens 112-122 2861869-2 1985 Fibrin polymers derived from des A fibrinogen and des A,B fibrinogen increased sixfold the rate of thrombin-catalyzed factor XIIIa formation in the presence of EDTA. Edetic Acid 160-164 fibrinogen beta chain Homo sapiens 35-45 2861869-2 1985 Fibrin polymers derived from des A fibrinogen and des A,B fibrinogen increased sixfold the rate of thrombin-catalyzed factor XIIIa formation in the presence of EDTA. Edetic Acid 160-164 fibrinogen beta chain Homo sapiens 58-68 2861869-3 1985 Calcium chloride accelerated factor XIIIa formation 14-fold in the presence of des A,B fibrinogen without increasing the rate of thrombin formation. Calcium Chloride 0-16 fibrinogen beta chain Homo sapiens 87-97 2861869-6 1985 Glycyl-L-prolyl-L-arginyl-L-proline (gly-pro-arg-pro), a fibrin polymerization inhibitor, inhibited des A and des A,B fibrinogen from enhancing thrombin-catalyzed factor XIIIa formation. glycyl-l-prolyl-l-arginyl-l-proline 0-35 fibrinogen beta chain Homo sapiens 118-128 2861869-6 1985 Glycyl-L-prolyl-L-arginyl-L-proline (gly-pro-arg-pro), a fibrin polymerization inhibitor, inhibited des A and des A,B fibrinogen from enhancing thrombin-catalyzed factor XIIIa formation. glycyl-prolyl-arginyl-proline 37-52 fibrinogen beta chain Homo sapiens 118-128 4052020-14 1985 Our results therefore demonstrate that platelet fibrinogen expresses the heterozygous A alpha 16His phenotype. 16his 94-99 fibrinogen beta chain Homo sapiens 48-58 4049326-1 1985 DesAA-fibrin Sepharose was produced by treating fibrinogen-Sepharose with batroxobin. Sepharose 13-22 fibrinogen beta chain Homo sapiens 48-58 4049326-1 1985 DesAA-fibrin Sepharose was produced by treating fibrinogen-Sepharose with batroxobin. Sepharose 59-68 fibrinogen beta chain Homo sapiens 48-58 4049326-3 1985 After 2 hours at 37 degrees C, the Sepharose beads were separated by centrifugation and non-crosslinked fibrinogen was removed by twice times washing with guanidinium chloride, pH 4.1. Guanidine 155-175 fibrinogen beta chain Homo sapiens 104-114 2991399-0 1985 Ca+2 mobilization and fibrinogen binding of platelets refractory to adenosine diphosphate stimulation. Adenosine Diphosphate 68-89 fibrinogen beta chain Homo sapiens 22-32 2991399-1 1985 The mechanism of adenosine diphosphate (ADP)-induced refractoriness was explored with iodine 125-labeled fibrinogen and the fluorescent Ca+2 indicator quin-2-tetraacetoxymethyl ester (quin-2). Adenosine Diphosphate 17-38 fibrinogen beta chain Homo sapiens 105-115 2991399-1 1985 The mechanism of adenosine diphosphate (ADP)-induced refractoriness was explored with iodine 125-labeled fibrinogen and the fluorescent Ca+2 indicator quin-2-tetraacetoxymethyl ester (quin-2). Adenosine Diphosphate 40-43 fibrinogen beta chain Homo sapiens 105-115 2991399-10 1985 Restimulation of platelets with epinephrine also increased fibrinogen receptor exposure and restored the ability of platelets to aggregate, but was accompanied by barely detectable changes in quin-2 fluorescence similar to those observed with epinephrine-treated control platelets. Epinephrine 32-43 fibrinogen beta chain Homo sapiens 59-69 2991399-11 1985 Platelets incubated for 30 minutes with ADP and 125I-fibrinogen also showed an initial rise in quin-2 fluorescence, which returned to baseline levels during incubation, but the amount of platelet-bound fibrinogen, normal at the onset, remained quantitatively unchanged. Adenosine Diphosphate 40-43 fibrinogen beta chain Homo sapiens 202-212 2991399-11 1985 Platelets incubated for 30 minutes with ADP and 125I-fibrinogen also showed an initial rise in quin-2 fluorescence, which returned to baseline levels during incubation, but the amount of platelet-bound fibrinogen, normal at the onset, remained quantitatively unchanged. Quin2 95-101 fibrinogen beta chain Homo sapiens 53-63 3874235-4 1985 Of interest in this comparison is that both hFPA and hFPB are amino terminal peptides on the A and B chain of fibrinogen, respectively, and are readily cleaved by thrombin during fibrin formation and by other trypsin-like enzymes, leaving a carboxyl terminal Arg. Arginine 259-262 fibrinogen beta chain Homo sapiens 110-120 2996170-2 1985 SS inhibited dose-responsively ADP-induced aggregation in the presence of fibrinogen and Ca2+. Adenosine Diphosphate 31-34 fibrinogen beta chain Homo sapiens 74-84 3850647-6 1985 A stimulating effect of fibrinogen fragments could also be shown for the cleavage of the low molecular weight paranitroanilide substrate H-D-Pro-Phe-Arg-pNA by kallikrein; in that system the kcat for substrate cleavage by kallikrein increased from 200 s-1 to 280 s-1, while the Km value remained unchanged. paranitroanilide 110-126 fibrinogen beta chain Homo sapiens 24-34 3850647-6 1985 A stimulating effect of fibrinogen fragments could also be shown for the cleavage of the low molecular weight paranitroanilide substrate H-D-Pro-Phe-Arg-pNA by kallikrein; in that system the kcat for substrate cleavage by kallikrein increased from 200 s-1 to 280 s-1, while the Km value remained unchanged. H-D-Pro-Phe-Arg 137-152 fibrinogen beta chain Homo sapiens 24-34 4016157-1 1985 The time-course of ADP-triggered aggregation of human blood platelets has been followed by sensitive right-angle light scattering intensity measurements as a function of the platelet and fibrinogen concentrations. Adenosine Diphosphate 19-22 fibrinogen beta chain Homo sapiens 187-197 3161501-1 1985 A covalent conjugate between the plasminogen activator urokinase and polyclonal rabbit anti-human fibrinogen has been formed using the heterobifunctional coupling reagent N-succinimidyl 3-(2-pyridyldithio) propionate. N-succinimidyl 3-(2-pyridyldithio)propionate 171-216 fibrinogen beta chain Homo sapiens 98-108 3929831-3 1985 When clotting is effected by thrombin in the presence of calcium, the endotherm for the D nodules of fibrinogen broadens significantly and then becomes narrow again, while increasing in size. Calcium 57-64 fibrinogen beta chain Homo sapiens 101-111 4005267-8 1985 These studies suggest a specific but weak interaction of the solubilizing fibrinogen with the soluble fibrin polymers as demonstrated by a rapid exchange of both macromolecules. Polymers 109-117 fibrinogen beta chain Homo sapiens 74-84 2991335-2 1985 To investigate this mechanism, our previously described murine monoclonal antibody (10E5) and a new monoclonal antibody (7E3), both of which block the binding of fibrinogen to platelets and bind to GPIIb and/or GPIIIa, were radiolabeled and their rates of binding to native and ADP-activated platelets were studied. Adenosine Diphosphate 278-281 fibrinogen beta chain Homo sapiens 162-172 2411030-5 1985 Following infusion of HES and albumin, plasma fibrinogen and antithrombin-III levels fell slightly due to plasma volume expansion and hemodilution. Hydroxyethyl Starch Derivatives 22-25 fibrinogen beta chain Homo sapiens 46-56 2930939-8 1985 Thromboxane A2 is a known inducer of platelet aggregation probably through the exposure of platelet fibrinogen receptors. Thromboxane A2 0-14 fibrinogen beta chain Homo sapiens 100-110 4035652-2 1985 The precipitate was subjected to sodium dodecyl sulfate polyacrylamide gel electrophoresis, confirming that fibrinogen was a major component. Sodium Dodecyl Sulfate 33-55 fibrinogen beta chain Homo sapiens 108-118 4049780-6 1985 Urokinase coupling to fibrinogen via aliphatic diamine "spacer group" increases the affinity of the modified enzyme derivative to thrombus material. Diamines 47-54 fibrinogen beta chain Homo sapiens 22-32 3997886-8 1985 Most of the incorporation of 125I-thrombospondin occurred during fibrin polymerization as judged by parallel studies of the incorporation of 125I-fibrinogen. 125i-thrombospondin 29-48 fibrinogen beta chain Homo sapiens 146-156 4040660-0 1985 Species specificity in the acceleration of tissue-type plasminogen activator-mediated activation of plasminogens, by fibrinogen cyanogen bromide fragments. Cyanogen Bromide 128-144 fibrinogen beta chain Homo sapiens 117-127 4035652-2 1985 The precipitate was subjected to sodium dodecyl sulfate polyacrylamide gel electrophoresis, confirming that fibrinogen was a major component. polyacrylamide 56-70 fibrinogen beta chain Homo sapiens 108-118 4035652-4 1985 The amount of fibrinogen precipitation was strongly dependent on H3 concentration. HS 3 65-67 fibrinogen beta chain Homo sapiens 14-24 4035652-6 1985 Fibrinogen subjected to gelatin-Sepharose chromatography or dialysis against 3.3M urea reacted equivalently with H3. Sepharose 32-41 fibrinogen beta chain Homo sapiens 0-10 4035652-6 1985 Fibrinogen subjected to gelatin-Sepharose chromatography or dialysis against 3.3M urea reacted equivalently with H3. Urea 82-86 fibrinogen beta chain Homo sapiens 0-10 4035652-6 1985 Fibrinogen subjected to gelatin-Sepharose chromatography or dialysis against 3.3M urea reacted equivalently with H3. HS 3 113-115 fibrinogen beta chain Homo sapiens 0-10 4035652-10 1985 Of the fibrinogen degradation products, only fragment X precipitated significantly when incubated with H3. HS 3 103-105 fibrinogen beta chain Homo sapiens 7-17 4035652-13 1985 Fragment D inhibited the precipitation of fibrinogen by H3 or protamine. HS 3 56-58 fibrinogen beta chain Homo sapiens 42-52 3895289-2 1985 The rate of positive 125I-fibrinogen accumulations after typical ascending phlebography was significantly less (9/40 = 23%) with iopamidol compared with ioxithalamate (16/40 = 40%). Iopamidol 129-138 fibrinogen beta chain Homo sapiens 26-36 2859508-4 1985 Haemostatic tests in cyclosporin-treated and azathioprine-treated patients and normal subjects (10 in each group) showed increased concentrations of factor VIII C, fibrinogen, antithrombin III, and protein C in the cyclosporin-treated patients. Cyclosporine 21-32 fibrinogen beta chain Homo sapiens 164-174 2859508-4 1985 Haemostatic tests in cyclosporin-treated and azathioprine-treated patients and normal subjects (10 in each group) showed increased concentrations of factor VIII C, fibrinogen, antithrombin III, and protein C in the cyclosporin-treated patients. Azathioprine 45-57 fibrinogen beta chain Homo sapiens 164-174 3158213-1 1985 The progressive stabilization of fibrinogen binding to ADP-treated platelets has been well described, but the nature of this interaction remains obscure. Adenosine Diphosphate 55-58 fibrinogen beta chain Homo sapiens 33-43 3158213-2 1985 In the present study, irreversibly bound fibrinogen was defined as that fraction of bound iodinated fibrinogen that failed to dissociate from stimulated human gel-filtered platelets within 10 min of adding 10 mM ethylenediaminetetraacetic acid. Edetic Acid 212-243 fibrinogen beta chain Homo sapiens 41-51 3158213-3 1985 It represented 16 +/- 11% (mean +/- SD, n = 10) of fibrinogen bound to ADP-treated platelets after 1 min and 52 +/- 11% of fibrinogen bound to these platelets after 60 min. Adenosine Diphosphate 71-74 fibrinogen beta chain Homo sapiens 51-61 3158213-5 1985 Irreversible fibrinogen binding was significantly reduced at 4 degrees C (27 +/- 9%, mean +/- SD, n = 6) if platelets were preincubated (30 min, 25 degrees C) with 30 micrograms/ml cytochalasin B or D (18 +/- 8%) or stimulated with chymotrypsin (0.5 mg/2-3 X 10(8) platelets) (31 +/- 8%). Cytochalasins 181-193 fibrinogen beta chain Homo sapiens 13-23 3158213-6 1985 Formation of irreversible platelet-fibrinogen interactions correlated with the incorporation of actin and actin-binding protein into the Triton X-100-insoluble platelet cytoskeleton and the ability of platelets to retract fibrin clots. Octoxynol 137-149 fibrinogen beta chain Homo sapiens 35-45 3158281-1 1985 Calcium limits the plasmic proteolysis of fibrinogen fragment D by binding to a specific site on the carboxy-terminal segment of the D gamma chain. Calcium 0-7 fibrinogen beta chain Homo sapiens 42-52 3158281-2 1985 Employing sodium dodecyl sulfate-polyacrylamide gel electrophoresis to visualize plasmic fragments, Sr2+, Ba2+, and Mn2+ were found to have an equivalent capacity to limit the degradation of fibrinogen fragment D (Mr 94,000). Sodium Dodecyl Sulfate 10-32 fibrinogen beta chain Homo sapiens 191-201 3158281-2 1985 Employing sodium dodecyl sulfate-polyacrylamide gel electrophoresis to visualize plasmic fragments, Sr2+, Ba2+, and Mn2+ were found to have an equivalent capacity to limit the degradation of fibrinogen fragment D (Mr 94,000). strontium cation 100-104 fibrinogen beta chain Homo sapiens 191-201 3158281-2 1985 Employing sodium dodecyl sulfate-polyacrylamide gel electrophoresis to visualize plasmic fragments, Sr2+, Ba2+, and Mn2+ were found to have an equivalent capacity to limit the degradation of fibrinogen fragment D (Mr 94,000). N-methyl-valyl-amiclenomycin 106-110 fibrinogen beta chain Homo sapiens 191-201 3158281-2 1985 Employing sodium dodecyl sulfate-polyacrylamide gel electrophoresis to visualize plasmic fragments, Sr2+, Ba2+, and Mn2+ were found to have an equivalent capacity to limit the degradation of fibrinogen fragment D (Mr 94,000). Manganese(2+) 116-120 fibrinogen beta chain Homo sapiens 191-201 2408362-3 1985 Results of in vivo studies were as follows: following infusion of 1 liter of 6 percent HES into healthy subjects, fibrinogen and antithrombin-III concentrations fell slightly due to plasma volume expansion and consequent dilution. Hydroxyethyl Starch Derivatives 87-90 fibrinogen beta chain Homo sapiens 114-124 4024044-1 1985 The attachment of urokinase to fibrinogen via a "spacer" of aliphatic diamine increases the affinity of the modified enzyme to the fibrin clot. aliphatic diamine 60-77 fibrinogen beta chain Homo sapiens 31-41 4012675-3 1985 The results, which were highly consistent between different individuals, showed that fibrinogen increases aggregability as measured by the ADP ED50, the dose of adenosine diphosphate at which aggregation proceeds at half its maximum velocity. Adenosine Diphosphate 161-182 fibrinogen beta chain Homo sapiens 85-95 4024537-1 1985 Trimethylsilyl heparin formed a complex with fibrinogen, caused anticoagulation and antipolymerization effects on fibrin-monomer as well as exhibited nonenzymatic fibrinolytic activity towards unstabilized fibrin. trimethylsilyl heparin 0-22 fibrinogen beta chain Homo sapiens 45-55 3886645-1 1985 Effect on the interaction of fibrinogen with thrombin from diethyl pyrocarbonate-modified prothrombin. Diethyl Pyrocarbonate 59-80 fibrinogen beta chain Homo sapiens 29-39 3886645-3 1985 Diethyl pyrocarbonate inactivated the potential fibrinogen-clotting activity of prothrombin with a second-order rate constant of 70 M-1 min-1 at pH 6.0 and 25 degrees C. The difference spectrum of the modified protein had a maximum absorption at 240 nm which is characteristic of N-carbethoxyhistidine. Diethyl Pyrocarbonate 0-21 fibrinogen beta chain Homo sapiens 48-58 3886645-3 1985 Diethyl pyrocarbonate inactivated the potential fibrinogen-clotting activity of prothrombin with a second-order rate constant of 70 M-1 min-1 at pH 6.0 and 25 degrees C. The difference spectrum of the modified protein had a maximum absorption at 240 nm which is characteristic of N-carbethoxyhistidine. N-carbethoxyhistidine 280-301 fibrinogen beta chain Homo sapiens 48-58 3886645-5 1985 Addition of hydroxylamine to ethoxyformylated prothrombin reversed the loss of fibrinogen-clotting activity. Hydroxylamine 12-25 fibrinogen beta chain Homo sapiens 79-89 3886645-8 1985 Statistical analysis of residual enzyme activity and extent of modification indicates that among 7 histidyl residues modified per molecule, there is 1 essential histidine (not in the active site) involved in the potential fibrinogen-clotting activity of prothrombin. Histidine 161-170 fibrinogen beta chain Homo sapiens 222-232 2858711-7 1985 At the end of the rt-PA infusion the circulating fibrinogen level was 61 +/- 35% of the starting value, as measured by a coagulation-rate assay, and 69 +/- 25% as measured by sodium sulphite precipitation. rt-pa 18-23 fibrinogen beta chain Homo sapiens 49-59 2858711-9 1985 In the rt-PA group only 4.5% of the fibrinogen was measured as incoagulable fibrinogen degradation products, compared with 30% in the streptokinase group. rt-pa 7-12 fibrinogen beta chain Homo sapiens 36-46 2858711-9 1985 In the rt-PA group only 4.5% of the fibrinogen was measured as incoagulable fibrinogen degradation products, compared with 30% in the streptokinase group. rt-pa 7-12 fibrinogen beta chain Homo sapiens 76-86 3985042-3 1985 This report describes the clinical course of a patient who at the time of diagnosis of nonmetastatic renal cell carcinoma had dysfibrinogenemia characterized by prolongation of the thrombin and Reptilase times and increased sialic acid content of the purified fibrinogen. N-Acetylneuraminic Acid 224-235 fibrinogen beta chain Homo sapiens 129-139 2579690-3 1985 Thrombin-induced secretion in Tyrode-Ca2+ was followed by both anti-TSP and anti-fib binding, with large clusters of gold particles observed on the platelet surface. tyrode 30-36 fibrinogen beta chain Homo sapiens 81-84 2579690-7 1985 Platelets activated with ADP in the presence of added fib, and subsequently incubated with anti-fib IgG, showed small particle clusters over the whole platelet surface. Adenosine Diphosphate 25-28 fibrinogen beta chain Homo sapiens 54-57 2409213-4 1985 In the case of the digoxin determination, using the Enzymun-Test Digoxin, it is possible to abolish interference by fibrinogen by thermal coagulation (plasma is heated at 56 degrees C for 30 min) and removal of the fibrinogen. Digoxin 19-26 fibrinogen beta chain Homo sapiens 116-126 2409213-4 1985 In the case of the digoxin determination, using the Enzymun-Test Digoxin, it is possible to abolish interference by fibrinogen by thermal coagulation (plasma is heated at 56 degrees C for 30 min) and removal of the fibrinogen. Digoxin 19-26 fibrinogen beta chain Homo sapiens 215-225 2409213-4 1985 In the case of the digoxin determination, using the Enzymun-Test Digoxin, it is possible to abolish interference by fibrinogen by thermal coagulation (plasma is heated at 56 degrees C for 30 min) and removal of the fibrinogen. Digoxin 65-72 fibrinogen beta chain Homo sapiens 116-126 2409213-4 1985 In the case of the digoxin determination, using the Enzymun-Test Digoxin, it is possible to abolish interference by fibrinogen by thermal coagulation (plasma is heated at 56 degrees C for 30 min) and removal of the fibrinogen. Digoxin 65-72 fibrinogen beta chain Homo sapiens 215-225 2409213-5 1985 Alternatively, addition of urea to the antigen-antibody reaction mixture decreases the interference caused by fibrinogen. Urea 27-31 fibrinogen beta chain Homo sapiens 110-120 2984300-7 1985 Prostaglandin E1 (0.3 mumol/L) in the perfusion circuit preserved the ability of platelets to react with fibrinogen. Alprostadil 0-16 fibrinogen beta chain Homo sapiens 105-115 3981309-4 1985 Our data suggest that a sudden fall in erythrocyte sedimentation rate or in platelet and fibrinogen levels may mark the start of this complication and may be an indication for rapid steroid therapy. Steroids 182-189 fibrinogen beta chain Homo sapiens 89-99 2409715-13 1985 Ethanol partially diminished the binding of immunoglobulin G, fibrinogen, fibronectin and alpha 2-macroglobulin. Ethanol 0-7 fibrinogen beta chain Homo sapiens 62-72 3156054-0 1985 C-terminal lysine residues of fibrinogen fragments essential for binding to plasminogen. Lysine 11-17 fibrinogen beta chain Homo sapiens 30-40 3156054-1 1985 Experiments involving affinity chromatography on immobilized plasminogen columns and the concomitant use of plasmin and carboxypeptidase B indicate that the COOH-terminal lysine residues formed by plasmin-catalyzed cleavage of fibrinogen are essential for the high-affinity binding of the resulting cleavage products to plasminogen. Lysine 171-177 fibrinogen beta chain Homo sapiens 227-237 3983914-0 1985 FXIII induced gelation of human fibrinogen--an alternative thiol enhanced, thrombin independent pathway. Sulfhydryl Compounds 59-64 fibrinogen beta chain Homo sapiens 32-42 3983914-1 1985 Factor XIII induced gelation of human fibrinogen in the presence of calcium ions. Calcium 68-75 fibrinogen beta chain Homo sapiens 38-48 3983914-10 1985 We also observed that the clotting of fibrinogen by thrombin was perturbed by DTT. Dithiothreitol 78-81 fibrinogen beta chain Homo sapiens 38-48 3983914-11 1985 Preincubation of fibrinogen with calcium ions prevented this effect of DTT. Calcium 33-40 fibrinogen beta chain Homo sapiens 17-27 3983914-11 1985 Preincubation of fibrinogen with calcium ions prevented this effect of DTT. Dithiothreitol 71-74 fibrinogen beta chain Homo sapiens 17-27 3992511-4 1985 The fibrinogen concentration in the suspending medium of rabbit platelets was 2.5 +/- 0.9 micrograms/10(9) platelets, and upon stimulation with 9 microM ADP it increased to 10.7 +/- 2.9 micrograms/10(9) platelets. Adenosine Diphosphate 153-156 fibrinogen beta chain Homo sapiens 4-14 3992511-6 1985 The presence of prostaglandin E1 reduced the fibrinogen concentration to approximately 1 micrograms/10(9) platelets and prevented aggregation and loss of fibrinogen when the platelets were stimulated with ADP. Alprostadil 16-32 fibrinogen beta chain Homo sapiens 45-55 3992511-6 1985 The presence of prostaglandin E1 reduced the fibrinogen concentration to approximately 1 micrograms/10(9) platelets and prevented aggregation and loss of fibrinogen when the platelets were stimulated with ADP. Alprostadil 16-32 fibrinogen beta chain Homo sapiens 154-164 3992511-6 1985 The presence of prostaglandin E1 reduced the fibrinogen concentration to approximately 1 micrograms/10(9) platelets and prevented aggregation and loss of fibrinogen when the platelets were stimulated with ADP. Adenosine Diphosphate 205-208 fibrinogen beta chain Homo sapiens 154-164 3992511-7 1985 With human platelets, the extracellular concentrations of fibrinogen and beta-thromboglobulin, expressed as percentages of the amount in the platelets, were similar, and the increase in fibrinogen concentration upon ADP stimulation (approximately 2%) was much lower than with rabbit platelets. Adenosine Diphosphate 216-219 fibrinogen beta chain Homo sapiens 186-196 3992511-8 1985 We conclude that rabbit platelets may release fibrinogen from their alpha-granules when stimulated with ADP, and that a portion of the released fibrinogen becomes available to support aggregation. Adenosine Diphosphate 104-107 fibrinogen beta chain Homo sapiens 46-56 3994730-4 1985 Fibrinogen and fetuin showed inhibitory effects on catalysis of ascorbate oxidation, whereas transferrin, citric acid, or other related substances exhibited no effect. Ascorbic Acid 64-73 fibrinogen beta chain Homo sapiens 0-10 3882374-4 1985 Protein blot analysis of lysates of cells carrying p166.9 demonstrates the IPTG-dependent synthesis of polypeptides which cross react with antisera to the A alpha-chain of human fibrinogen. Isopropyl Thiogalactoside 75-79 fibrinogen beta chain Homo sapiens 178-188 3920098-2 1985 In non-diabetic subjects, 0.95 +/- 0.17 mol glucose was bound per mol fibrinogen, whereas in the diabetic subjects 1.33 +/- 0.21 mol glucose was bound per mol fibrinogen (mean +/- SD, p less than 0.001). Glucose 44-51 fibrinogen beta chain Homo sapiens 70-80 4024044-5 1985 Fibrinogen modified with diamines does not lose the ability to be co-polymerized in the three-dimensional fibrin clot under the action of thrombin and acquires increased stability towards proteolytic degradation. Diamines 25-33 fibrinogen beta chain Homo sapiens 0-10 2981130-12 1985 The combined data suggest that the glycoprotein IIb-IIIa complex of platelets from diabetic subjects is similar to that of platelets from normal subjects and that the increased fibrinogen binding and aggregation of platelets from diabetic subjects in response to ADP or collagen is mediated by increased formation of prostaglandin endoperoxide or thromboxane A2, or both. Prostaglandin Endoperoxides 317-343 fibrinogen beta chain Homo sapiens 177-187 3156146-2 1985 We found the following: ticlopidine significantly (P less than 0.001) prolonged the skin bleeding time and impaired the binding of radiolabeled fibrinogen and von Willebrand Factor, the clot retraction and the aggregation of platelets in response to ADP, epinephrine, thrombin, ionophore A23187, collagen, or arachidonic acid. Ticlopidine 24-35 fibrinogen beta chain Homo sapiens 144-154 2865502-4 1985 In the rt-PA group the circulating fibrinogen level at the end of the catheterisation was 52 +/- 29% (mean +/- SD) of the starting value. rt-pa 7-12 fibrinogen beta chain Homo sapiens 35-45 2944348-5 1985 However, at high concentration of heparin, plasmin inactivation by antithrombin III is accelerated even in the presence of fibrinogen or fibrin. Heparin 34-41 fibrinogen beta chain Homo sapiens 123-133 4096744-0 1985 Effects of ticlopidine on blood fibrinogen and blood viscosity in peripheral atherosclerotic disease. Ticlopidine 11-22 fibrinogen beta chain Homo sapiens 32-42 4096744-5 1985 The fibrinogen levels resulted significantly lowered during 90 days of treatment with ticlopidine, while that was not evident in the nicotinate group. Ticlopidine 86-97 fibrinogen beta chain Homo sapiens 4-14 4096744-9 1985 A direct or indirect action of ticlopidine on plasma fibrinogen is suggested. Ticlopidine 31-42 fibrinogen beta chain Homo sapiens 53-63 2981130-0 1985 Increased binding of fibrinogen to platelets in diabetes: the role of prostaglandins and thromboxane. Thromboxanes 89-100 fibrinogen beta chain Homo sapiens 21-31 2981130-1 1985 Previous studies suggested a role for prostaglandins or thromboxane A2, or both in the exposure of fibrinogen receptors on normal platelets in response to several aggregating agents. Prostaglandins 38-52 fibrinogen beta chain Homo sapiens 99-109 2981130-1 1985 Previous studies suggested a role for prostaglandins or thromboxane A2, or both in the exposure of fibrinogen receptors on normal platelets in response to several aggregating agents. Thromboxane A2 56-70 fibrinogen beta chain Homo sapiens 99-109 2981130-3 1985 We compared fibrinogen binding to platelets from diabetic subjects with binding to platelets from normal subjects and determined whether aspirin (which inhibits the formation of prostaglandins and thromboxane) would inhibit the binding of fibrinogen to platelets from diabetic subjects and whether this correlated with its effects on platelet aggregation. Aspirin 137-144 fibrinogen beta chain Homo sapiens 239-249 2981130-6 1985 Binding of 125I-fibrinogen following stimulation of platelets by ADP or collagen was greater in diabetic (because more binding sites were exposed) than in normal subjects. Adenosine Diphosphate 65-68 fibrinogen beta chain Homo sapiens 16-26 2981130-12 1985 The combined data suggest that the glycoprotein IIb-IIIa complex of platelets from diabetic subjects is similar to that of platelets from normal subjects and that the increased fibrinogen binding and aggregation of platelets from diabetic subjects in response to ADP or collagen is mediated by increased formation of prostaglandin endoperoxide or thromboxane A2, or both. Adenosine Diphosphate 263-266 fibrinogen beta chain Homo sapiens 177-187 2416650-0 1985 Unreliability in the estimation of the molecular weight of fibrinogen degradation products (FDPs) by polyacrylamide/sodium dodecyl sulphate electrophoresis (SDS/PAGE). Sodium Dodecyl Sulfate 157-160 fibrinogen beta chain Homo sapiens 59-69 2581874-2 1985 Fibrinogen was isolated from plasmas by affinity chromatography at fibrin monomer Sepharose and characterized by SDS-PAGE. Sepharose 82-91 fibrinogen beta chain Homo sapiens 0-10 2981130-12 1985 The combined data suggest that the glycoprotein IIb-IIIa complex of platelets from diabetic subjects is similar to that of platelets from normal subjects and that the increased fibrinogen binding and aggregation of platelets from diabetic subjects in response to ADP or collagen is mediated by increased formation of prostaglandin endoperoxide or thromboxane A2, or both. Thromboxane A2 347-361 fibrinogen beta chain Homo sapiens 177-187 2581874-2 1985 Fibrinogen was isolated from plasmas by affinity chromatography at fibrin monomer Sepharose and characterized by SDS-PAGE. Sodium Dodecyl Sulfate 113-116 fibrinogen beta chain Homo sapiens 0-10 3884410-2 1985 Compared with the fifteen control patients (treated with placebo), the fifteen patients treated with Sulodexide showed a significant decrease in blood triglycerides and fibrinogen as well as a significantly increased HDL-cholesterol, and positive instrumental changes: at the end of treatment Peak and Rest Flow values--and consequently also Winsor"s index--were significantly increased only in patients treated with Sulodexide. glucuronyl glucosamine glycan sulfate 101-111 fibrinogen beta chain Homo sapiens 169-179 4077872-8 1985 For example, on carbon, individual fibrinogen molecules retain their trinodular structure and adsorb randomly until a monolayer forms. Carbon 16-22 fibrinogen beta chain Homo sapiens 35-45 4077872-9 1985 On polystyrene, the individual fibrinogen molecules appear as globules and a network forms before complete coverage occurs. Polystyrenes 3-14 fibrinogen beta chain Homo sapiens 31-41 3883367-3 1985 Results indicated preservation of platelets, leukocytes and fibrinogen levels, together with shortened activated partial thromboplastin times and fewer fibrinogen degradation products post-bypass in PGI2-treated animals. Epoprostenol 199-203 fibrinogen beta chain Homo sapiens 152-162 4011126-3 1985 Calcium dobesilate was found to reduce whole-blood viscosity in a statistically significant manner which was accompanied by a diminution of the albumin/globulin ratio and a significant reduction of fibrinogen and cholesterol levels. Calcium Dobesilate 0-18 fibrinogen beta chain Homo sapiens 198-208 3983897-1 1985 Fibrinogen was purified from fresh citrated human plasma by precipitation with beta-alanine in the presence of citrate and protease inhibitors. Citric Acid 35-42 fibrinogen beta chain Homo sapiens 0-10 3983897-1 1985 Fibrinogen was purified from fresh citrated human plasma by precipitation with beta-alanine in the presence of citrate and protease inhibitors. beta-Alanine 79-91 fibrinogen beta chain Homo sapiens 0-10 3976012-0 1985 [Complexes of the N-terminal disulfide branch point of fibrin with fibrinogen]. Disulfides 29-38 fibrinogen beta chain Homo sapiens 67-77 3976012-1 1985 Investigation of fibrin N-terminal disulphide knot (N-DSK) binding with fibrinogen (F) showed, that the F-N-DSK-complex represents growing polymer structure which is soluble at early polymerization stage and forms a solid phase during the further growth. disulphide 35-45 fibrinogen beta chain Homo sapiens 72-82 3976012-1 1985 Investigation of fibrin N-terminal disulphide knot (N-DSK) binding with fibrinogen (F) showed, that the F-N-DSK-complex represents growing polymer structure which is soluble at early polymerization stage and forms a solid phase during the further growth. Polymers 139-146 fibrinogen beta chain Homo sapiens 72-82 6437459-0 1984 Effects of variant gamma chains and sialic acid content of fibrinogen upon its interactions with ADP-stimulated human and rabbit platelets. N-Acetylneuraminic Acid 36-47 fibrinogen beta chain Homo sapiens 59-69 6437459-0 1984 Effects of variant gamma chains and sialic acid content of fibrinogen upon its interactions with ADP-stimulated human and rabbit platelets. Adenosine Diphosphate 97-100 fibrinogen beta chain Homo sapiens 59-69 6437459-1 1984 When platelets are stimulated with adenosine diphosphate (ADP), fibrinogen binds to receptors on the platelet membrane, and the platelets aggregate. Adenosine Diphosphate 35-56 fibrinogen beta chain Homo sapiens 64-74 6437459-1 1984 When platelets are stimulated with adenosine diphosphate (ADP), fibrinogen binds to receptors on the platelet membrane, and the platelets aggregate. Adenosine Diphosphate 58-61 fibrinogen beta chain Homo sapiens 64-74 6437459-3 1984 Normal human fibrinogen, which consists of three pairs of disulfide-bonded peptide chains, (A alpha, B beta, gamma)2, is heterogeneous with respect to sialic acid content and also contains a small proportion of molecules with a variant gamma chain (designated gamma"), elongated by a peptide extension at the COOH-terminus of the normal gamma chain. Disulfides 58-67 fibrinogen beta chain Homo sapiens 13-23 6437459-3 1984 Normal human fibrinogen, which consists of three pairs of disulfide-bonded peptide chains, (A alpha, B beta, gamma)2, is heterogeneous with respect to sialic acid content and also contains a small proportion of molecules with a variant gamma chain (designated gamma"), elongated by a peptide extension at the COOH-terminus of the normal gamma chain. N-Acetylneuraminic Acid 151-162 fibrinogen beta chain Homo sapiens 13-23 6437459-6 1984 In binding and aggregation experiments, we detected no significant differences between the reactions of the first two fractions, but ADP-stimulated platelets bound only 50% as much of 125I-fibrinogen from the fraction with the gamma" chains and also aggregated less extensively in the presence of this fraction. Adenosine Diphosphate 133-136 fibrinogen beta chain Homo sapiens 189-199 6437459-7 1984 We conclude that the sialic acid content of fibrinogen does not significantly affect its interactions with platelets, but the elongated gamma" chains bind less effectively to ADP-stimulated platelets, and thus reduce the ability of fibrinogen to support aggregation. N-Acetylneuraminic Acid 21-32 fibrinogen beta chain Homo sapiens 44-54 6437459-7 1984 We conclude that the sialic acid content of fibrinogen does not significantly affect its interactions with platelets, but the elongated gamma" chains bind less effectively to ADP-stimulated platelets, and thus reduce the ability of fibrinogen to support aggregation. Adenosine Diphosphate 175-178 fibrinogen beta chain Homo sapiens 232-242 6441307-0 1984 Specific fibrinogen quantitation by electroimmunodiffusion in agarose gel containing heparin. Sepharose 62-69 fibrinogen beta chain Homo sapiens 9-19 6441307-0 1984 Specific fibrinogen quantitation by electroimmunodiffusion in agarose gel containing heparin. Heparin 85-92 fibrinogen beta chain Homo sapiens 9-19 6441307-1 1984 In the determination of plasma fibrinogen by electroimmunodiffusion, commercial sodium heparin, previously included in the agarose gel, by interacting with fibrinogen molecules, enhances their anodic mobility more strongly than after carbamylation with potassium cyanate. Heparin 80-94 fibrinogen beta chain Homo sapiens 31-41 6441307-1 1984 In the determination of plasma fibrinogen by electroimmunodiffusion, commercial sodium heparin, previously included in the agarose gel, by interacting with fibrinogen molecules, enhances their anodic mobility more strongly than after carbamylation with potassium cyanate. Heparin 80-94 fibrinogen beta chain Homo sapiens 156-166 6441307-1 1984 In the determination of plasma fibrinogen by electroimmunodiffusion, commercial sodium heparin, previously included in the agarose gel, by interacting with fibrinogen molecules, enhances their anodic mobility more strongly than after carbamylation with potassium cyanate. Sepharose 123-130 fibrinogen beta chain Homo sapiens 156-166 2416650-0 1985 Unreliability in the estimation of the molecular weight of fibrinogen degradation products (FDPs) by polyacrylamide/sodium dodecyl sulphate electrophoresis (SDS/PAGE). polyacrylamide 101-115 fibrinogen beta chain Homo sapiens 59-69 2416650-0 1985 Unreliability in the estimation of the molecular weight of fibrinogen degradation products (FDPs) by polyacrylamide/sodium dodecyl sulphate electrophoresis (SDS/PAGE). Sodium Dodecyl Sulfate 116-139 fibrinogen beta chain Homo sapiens 59-69 6529554-1 1984 Sialylated biantennary glycopeptides from human fibrinogen were analyzed with fast atom bombardment mass spectrometry. Glycopeptides 23-36 fibrinogen beta chain Homo sapiens 48-58 6388898-7 1984 Levels of circulating fibrinogen decreased after treatment with rt-PA by an average of only 8% of baseline values. rt-pa 64-69 fibrinogen beta chain Homo sapiens 22-32 6210119-1 1984 The authors have modified alpha-chymotrypsin covalently bound via aldehyde dextran with polyclonal antibodies to fibrinogen. aldehyde dextran 66-82 fibrinogen beta chain Homo sapiens 113-123 6236859-1 1984 Two monoclonal antibodies--one that blocks ristocetin-induced platelet binding of von Willebrand factor to glycoprotein Ib and one that blocks adenosine diphosphate-induced binding of fibrinogen to the glycoprotein IIb/IIIa complex--were used to assess the binding site(s) for von Willebrand factor when platelets are stimulated with thrombin or adenosine diphosphate (ADP). Adenosine Diphosphate 143-164 fibrinogen beta chain Homo sapiens 184-194 6383458-9 1984 Haematin induced binding of fibrinogen to platelets, and failed to aggregate thrombasthenic platelets. Hemin 0-8 fibrinogen beta chain Homo sapiens 28-38 6383458-10 1984 These findings indicate that haematin may induce platelet aggregation by promoting influx of divalent cations in association with increased fibrinogen binding and release of adenine nucleotides. Hemin 29-37 fibrinogen beta chain Homo sapiens 140-150 6495268-2 1984 125I-fibrinogen binding during ADP-induced aggregation, and release of amine storage granule contents were also inhibited. Adenosine Diphosphate 31-34 fibrinogen beta chain Homo sapiens 5-15 6238619-3 1984 Phosphorylation of Ser-3 of the A alpha chain appears to increase the rate of release of the corresponding phosphorylated peptide A from fibrinogen, due to enhanced binding of thrombin (lower value of the Michaelis-Menten constant KM). Serine 19-22 fibrinogen beta chain Homo sapiens 137-147 6088505-2 1984 Hep-G2 cells, incubated with L-[35S]methionine, incorporate radioactivity into fibrinogen and several fibrinogen-related compounds. L-Methionine-35S 29-46 fibrinogen beta chain Homo sapiens 79-89 6088505-2 1984 Hep-G2 cells, incubated with L-[35S]methionine, incorporate radioactivity into fibrinogen and several fibrinogen-related compounds. L-Methionine-35S 29-46 fibrinogen beta chain Homo sapiens 102-112 6088505-9 1984 Later other A alpha and gamma chains are added by ordered disulfide interaction, leading to the eventual formation of dimeric fibrinogen. Disulfides 58-67 fibrinogen beta chain Homo sapiens 126-136 6749207-5 1984 The relation between fibrinogen and infarction, and between fibrinogen and stroke, became weaker when blood pressure, serum cholesterol, and smoking habits were taken into account, but was still significant for stroke. Cholesterol 124-135 fibrinogen beta chain Homo sapiens 21-31 6495268-5 1984 Fibrinogen-induced aggregation of chymotrypsin-treated platelets was blocked by the amino sugars. Amino Sugars 84-96 fibrinogen beta chain Homo sapiens 0-10 6749207-5 1984 The relation between fibrinogen and infarction, and between fibrinogen and stroke, became weaker when blood pressure, serum cholesterol, and smoking habits were taken into account, but was still significant for stroke. Cholesterol 124-135 fibrinogen beta chain Homo sapiens 60-70 6495268-8 1984 One of the effects of the amino sugars, however, is interference with the binding of fibrinogen to platelets. Amino Sugars 26-38 fibrinogen beta chain Homo sapiens 85-95 6435279-3 1984 By addition of glycine buffer to a final concentration of 2.0 M at 26 degrees C, the bulk of fibrinogen was precipitated while factor VIII remained in solution. Glycine 15-22 fibrinogen beta chain Homo sapiens 93-103 6088225-0 1984 Platelet aggregation: its relation with ADP-induced fibrinogen binding to platelets and ADP-related membrane enzyme activities. Adenosine Diphosphate 40-43 fibrinogen beta chain Homo sapiens 52-62 6088225-3 1984 In the present study, experiments were conducted with washed human platelets to examine if a relationship existed between platelet aggregation, fibrinogen binding and the enzymatic degradation of ADP. Adenosine Diphosphate 196-199 fibrinogen beta chain Homo sapiens 144-154 6088225-4 1984 With 12 different platelet suspensions, a good correlation (P less than 0.01) was found between the extent of platelet aggregation and the amount of 125I-fibrinogen bound to platelets after ADP stimulation. Adenosine Diphosphate 190-193 fibrinogen beta chain Homo sapiens 154-164 6088225-6 1984 The binding of fibrinogen to platelets was inhibited in parallel with aggregation when ADP stimulation was impaired by the enzymatic degradation of ADP by the system creatine phosphate/creatine phosphokinase, or by the use of specific antagonists, such as ATP and AMP. Adenosine Diphosphate 87-90 fibrinogen beta chain Homo sapiens 15-25 6088225-6 1984 The binding of fibrinogen to platelets was inhibited in parallel with aggregation when ADP stimulation was impaired by the enzymatic degradation of ADP by the system creatine phosphate/creatine phosphokinase, or by the use of specific antagonists, such as ATP and AMP. Adenosine Diphosphate 148-151 fibrinogen beta chain Homo sapiens 15-25 6088225-6 1984 The binding of fibrinogen to platelets was inhibited in parallel with aggregation when ADP stimulation was impaired by the enzymatic degradation of ADP by the system creatine phosphate/creatine phosphokinase, or by the use of specific antagonists, such as ATP and AMP. Adenosine Triphosphate 256-259 fibrinogen beta chain Homo sapiens 15-25 6088225-6 1984 The binding of fibrinogen to platelets was inhibited in parallel with aggregation when ADP stimulation was impaired by the enzymatic degradation of ADP by the system creatine phosphate/creatine phosphokinase, or by the use of specific antagonists, such as ATP and AMP. Adenosine Monophosphate 264-267 fibrinogen beta chain Homo sapiens 15-25 6088225-8 1984 This effect occurred at lower concentrations of ATP or AMP than those required to inhibit ADP-induced platelet aggregation and fibrinogen binding. Adenosine Triphosphate 48-51 fibrinogen beta chain Homo sapiens 127-137 6088225-8 1984 This effect occurred at lower concentrations of ATP or AMP than those required to inhibit ADP-induced platelet aggregation and fibrinogen binding. Adenosine Monophosphate 55-58 fibrinogen beta chain Homo sapiens 127-137 6088225-9 1984 Our results demonstrate that ATP and AMP may be used as specific antagonists of the ADP-induced fibrinogen binding to platelets. Adenosine Triphosphate 29-32 fibrinogen beta chain Homo sapiens 96-106 6088225-9 1984 Our results demonstrate that ATP and AMP may be used as specific antagonists of the ADP-induced fibrinogen binding to platelets. Adenosine Monophosphate 37-40 fibrinogen beta chain Homo sapiens 96-106 6088225-9 1984 Our results demonstrate that ATP and AMP may be used as specific antagonists of the ADP-induced fibrinogen binding to platelets. Adenosine Diphosphate 84-87 fibrinogen beta chain Homo sapiens 96-106 6087354-8 1984 Conversely, unlabeled vWF inhibited ADP-induced binding of 125I-labeled fibrinogen (60 micrograms/ml) with an IC50 of 16 micrograms/ml. Adenosine Diphosphate 36-39 fibrinogen beta chain Homo sapiens 72-82 6087354-8 1984 Conversely, unlabeled vWF inhibited ADP-induced binding of 125I-labeled fibrinogen (60 micrograms/ml) with an IC50 of 16 micrograms/ml. Iodine-125 59-63 fibrinogen beta chain Homo sapiens 72-82 6087354-7 1984 Human fibrinogen inhibited in a competitive manner the ADP-induced binding of 125I-labeled vWF (9 micrograms/ml) with an IC50 of 25 micrograms/ml. Adenosine Diphosphate 55-58 fibrinogen beta chain Homo sapiens 6-16 6087354-7 1984 Human fibrinogen inhibited in a competitive manner the ADP-induced binding of 125I-labeled vWF (9 micrograms/ml) with an IC50 of 25 micrograms/ml. Iodine-125 78-82 fibrinogen beta chain Homo sapiens 6-16 6087354-9 1984 A synthetic dodecapeptide (Mr, 1188), analogous with the specific platelet receptor recognition site of human fibrinogen gamma chain (gamma 400-411), inhibited binding of both 125I-labeled vWF and 125I-labeled fibrinogen to ADP-treated platelets, whereas it was without effect on binding of 125I-labeled vWF to ristocetin-treated platelets. Adenosine Diphosphate 224-227 fibrinogen beta chain Homo sapiens 110-120 6087354-9 1984 A synthetic dodecapeptide (Mr, 1188), analogous with the specific platelet receptor recognition site of human fibrinogen gamma chain (gamma 400-411), inhibited binding of both 125I-labeled vWF and 125I-labeled fibrinogen to ADP-treated platelets, whereas it was without effect on binding of 125I-labeled vWF to ristocetin-treated platelets. Ristocetin 311-321 fibrinogen beta chain Homo sapiens 110-120 6087354-10 1984 These data indicate that vWF and fibrinogen have a common receptor mechanism for their interaction with human platelets that is dependent on ADP occupancy of its binding sites and is recognized by the sequence of 12 amino acid residues at the carboxyl terminus of the human fibrinogen gamma chain. Adenosine Diphosphate 141-144 fibrinogen beta chain Homo sapiens 33-43 6238443-2 1984 On digestion with leukocyte elastase, in the presence of calcium ions, the anticoagulant potency of fibrinogen digests first increases, then decreases sharply, and in late stages increases again. Calcium 57-64 fibrinogen beta chain Homo sapiens 100-110 6379981-0 1984 A survey of surface hemorheological experiments on the inhibition of fibrinogenin formation employing surface layers of fibrinogen systems with heparins and other substances. Heparin 144-152 fibrinogen beta chain Homo sapiens 69-79 6379981-4 1984 In subsequent studies of the viscoelasticity of surface layers of highly purified fibrinogen (97-100% clottability) of human and bovine origin, we found, with some heparins, marked lowering of surface viscous moduli (eta"s) and of surface elastic moduli (Gs). Heparin 164-172 fibrinogen beta chain Homo sapiens 82-92 6379981-8 1984 Calcium heparin and Ca2+ alone always increased eta"s and Gs, when added to the fibrinogen system. calcium heparin 0-15 fibrinogen beta chain Homo sapiens 80-90 6379981-10 1984 Preparations of fibrinogen in dog plasma, to which sodium heparin was added, resulted in a decrease of tau values. Heparin 51-65 fibrinogen beta chain Homo sapiens 16-26 6238443-5 1984 This is confirmed with pure fragments: X-like fragments (purified from elastase digests of fibrinogen of different stages by ammonium sulphate precipitation and ion-exchange chromatography) give an increase and decrease in anticlotting activity which correlates very well with that of the potency of the digest from which they are purified. Ammonium Sulfate 125-142 fibrinogen beta chain Homo sapiens 91-101 6474412-1 1984 An assay for thrombin is presented wherein thrombin-catalyzed hydrolysis at Arg-A alpha-16 to release fibrinopeptide A (FPA) from fibrinogen is measured using high-performance liquid chromatography (HPLC). Arginine 76-79 fibrinogen beta chain Homo sapiens 130-140 6437004-1 1984 Early work on the purification of factor VIII using polyethylene glycol (PEG) indicated that other polymers might also be used to precipitate factor VIII leaving fibrinogen in solution. Polymers 99-107 fibrinogen beta chain Homo sapiens 162-172 6742738-6 1984 The clearance of radioactive fibrinogen/thrombin clots from the subcutaneous tissues of the rat was found to be delayed if the rats were given epsilon amino caproic acid but it could not be increased with stanozolol. Aminocaproic Acid 143-169 fibrinogen beta chain Homo sapiens 29-39 6733424-0 1984 Deep venous insufficiency after postoperative thrombosis diagnosed with 125I-labelled fibrinogen uptake test. Iodine-125 72-76 fibrinogen beta chain Homo sapiens 86-96 6470402-0 1984 Fourier Transform Infrared Reflection Absorption Spectroscopy (FT-IRAS) of fibrinogen adsorbed on metal and metal oxide surfaces. Metals 98-103 fibrinogen beta chain Homo sapiens 75-85 6470402-3 1984 Fibrinogen spontaneously adsorbed from solution onto gold, titanium and aluminum was used as model systems. Aluminum 72-80 fibrinogen beta chain Homo sapiens 0-10 6470402-5 1984 The amide I bands of fibrinogen adsorbed on the metal surfaces shift towards higher frequencies (ca. Amides 4-9 fibrinogen beta chain Homo sapiens 21-31 6544771-4 1984 Qualitative tests show that prothrombin adsorbed to polyvinylchloride can be activated by Taipan snake venom to generate thrombin that clots fibrinogen. Polyvinyl Chloride 52-69 fibrinogen beta chain Homo sapiens 141-151 6722179-5 1984 We conclude that the electric charge in the neighbourhood of the carbohydrate in both chains, B beta and gamma plays an important role in the attraction between monomeric fibrin and fibrinogen-monomeric fibrin. Carbohydrates 65-77 fibrinogen beta chain Homo sapiens 182-192 6733283-1 1984 We recently described a monoclonal antibody, 10E5 , that completely blocks adenosine diphosphate (ADP) induced fibrinogen binding to platelets and aggregation induced by ADP, epinephrine, and thrombin. Adenosine Diphosphate 75-96 fibrinogen beta chain Homo sapiens 111-121 6733283-1 1984 We recently described a monoclonal antibody, 10E5 , that completely blocks adenosine diphosphate (ADP) induced fibrinogen binding to platelets and aggregation induced by ADP, epinephrine, and thrombin. Adenosine Diphosphate 98-101 fibrinogen beta chain Homo sapiens 111-121 6733283-1 1984 We recently described a monoclonal antibody, 10E5 , that completely blocks adenosine diphosphate (ADP) induced fibrinogen binding to platelets and aggregation induced by ADP, epinephrine, and thrombin. Adenosine Diphosphate 170-173 fibrinogen beta chain Homo sapiens 111-121 6733283-1 1984 We recently described a monoclonal antibody, 10E5 , that completely blocks adenosine diphosphate (ADP) induced fibrinogen binding to platelets and aggregation induced by ADP, epinephrine, and thrombin. Epinephrine 175-186 fibrinogen beta chain Homo sapiens 111-121 6733283-9 1984 These data suggest that the fibrinogen receptor on chymotrypsin-treated platelets is identical to that on ADP-treated platelets and that this receptor is either near to, or on, the glycoprotein IIb/IIIa complex. Adenosine Diphosphate 106-109 fibrinogen beta chain Homo sapiens 28-38 6205441-0 1984 An abnormal fibrinogen (Copenhagen II) with increased sialic acid content associated with thrombotic tendency and normal liver function. N-Acetylneuraminic Acid 54-65 fibrinogen beta chain Homo sapiens 12-22 6205441-1 1984 An increased sialic acid content of the fibrinogen molecule is found in foetal fibrinogen and as an acquired disorder in hepatic disease. N-Acetylneuraminic Acid 13-24 fibrinogen beta chain Homo sapiens 40-50 6205441-1 1984 An increased sialic acid content of the fibrinogen molecule is found in foetal fibrinogen and as an acquired disorder in hepatic disease. N-Acetylneuraminic Acid 13-24 fibrinogen beta chain Homo sapiens 79-89 6205441-3 1984 The purified fibrinogen had a significantly increased content of sialic acid, an abnormal fibrin monomer polymerization, and a changed mobility in crossed affinity-immunoelectrophoresis using immobilized helix pomatia lectin. N-Acetylneuraminic Acid 65-76 fibrinogen beta chain Homo sapiens 13-23 6205441-5 1984 The occurrence of a thrombotic tendency and an increased fibrinogen sialic acid content without signs of liver disease may represent a new variant of congenital dysfibrinogenaemia. N-Acetylneuraminic Acid 68-79 fibrinogen beta chain Homo sapiens 57-67 6327361-0 1984 The in vitro stability in human plasma of two different technetium-99m-fibrinogen compounds. Technetium 56-66 fibrinogen beta chain Homo sapiens 71-81 6327361-0 1984 The in vitro stability in human plasma of two different technetium-99m-fibrinogen compounds. 1-[6-(2-hydroxypropan-2-yl)pyridin-2-yl]-6-{[4-(morpholin-4-yl)phenyl]amino}-2-(prop-2-en-1-yl)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one 67-70 fibrinogen beta chain Homo sapiens 71-81 6326566-0 1984 Effect of epinephrine on fibrinogen receptor exposure by aspirin-treated platelets and platelets from concentrates in response to ADP and thrombin. Epinephrine 10-21 fibrinogen beta chain Homo sapiens 25-35 6326566-0 1984 Effect of epinephrine on fibrinogen receptor exposure by aspirin-treated platelets and platelets from concentrates in response to ADP and thrombin. Aspirin 57-64 fibrinogen beta chain Homo sapiens 25-35 6326566-2 1984 Recently epinephrine was reported to induce maximal aggregation of aspirin-treated platelets when combined with ADP or thrombin, and to increase fibrinogen binding of non-aspirin treated platelets stimulated with low doses of ADP. Epinephrine 9-20 fibrinogen beta chain Homo sapiens 145-155 6326566-2 1984 Recently epinephrine was reported to induce maximal aggregation of aspirin-treated platelets when combined with ADP or thrombin, and to increase fibrinogen binding of non-aspirin treated platelets stimulated with low doses of ADP. Adenosine Diphosphate 226-229 fibrinogen beta chain Homo sapiens 145-155 6326566-3 1984 The present study extends these observations to correlate fibrinogen binding in response to various combinations of ADP, epinephrine, and thrombin with platelet aggregation and 14C-serotonin release using aspirin-treated platelets as well as platelets from stored concentrates. Adenosine Diphosphate 116-119 fibrinogen beta chain Homo sapiens 58-68 6326566-3 1984 The present study extends these observations to correlate fibrinogen binding in response to various combinations of ADP, epinephrine, and thrombin with platelet aggregation and 14C-serotonin release using aspirin-treated platelets as well as platelets from stored concentrates. Epinephrine 121-132 fibrinogen beta chain Homo sapiens 58-68 6326566-3 1984 The present study extends these observations to correlate fibrinogen binding in response to various combinations of ADP, epinephrine, and thrombin with platelet aggregation and 14C-serotonin release using aspirin-treated platelets as well as platelets from stored concentrates. Carbon-14 177-180 fibrinogen beta chain Homo sapiens 58-68 6326566-3 1984 The present study extends these observations to correlate fibrinogen binding in response to various combinations of ADP, epinephrine, and thrombin with platelet aggregation and 14C-serotonin release using aspirin-treated platelets as well as platelets from stored concentrates. Serotonin 181-190 fibrinogen beta chain Homo sapiens 58-68 6326566-3 1984 The present study extends these observations to correlate fibrinogen binding in response to various combinations of ADP, epinephrine, and thrombin with platelet aggregation and 14C-serotonin release using aspirin-treated platelets as well as platelets from stored concentrates. Aspirin 205-212 fibrinogen beta chain Homo sapiens 58-68 6326566-4 1984 When fresh platelets were stimulated with epinephrine (5 microM) together with either ADP (10 microM) or thrombin (150 mU/ml), fibrinogen binding increased by 180% compared to binding observed in response to ADP or thrombin alone. Epinephrine 42-53 fibrinogen beta chain Homo sapiens 127-137 6326566-4 1984 When fresh platelets were stimulated with epinephrine (5 microM) together with either ADP (10 microM) or thrombin (150 mU/ml), fibrinogen binding increased by 180% compared to binding observed in response to ADP or thrombin alone. Adenosine Diphosphate 86-89 fibrinogen beta chain Homo sapiens 127-137 6326566-6 1984 While both ADP and epinephrine potentiated the aggregation and fibrinogen binding of stored platelets in response to high doses of thrombin (150 mU/ml), maximal aggregation was achieved only with thrombin (150 mU/ml) and epinephrine (5 microM) in combination. Adenosine Diphosphate 11-14 fibrinogen beta chain Homo sapiens 63-73 6326566-6 1984 While both ADP and epinephrine potentiated the aggregation and fibrinogen binding of stored platelets in response to high doses of thrombin (150 mU/ml), maximal aggregation was achieved only with thrombin (150 mU/ml) and epinephrine (5 microM) in combination. Epinephrine 19-30 fibrinogen beta chain Homo sapiens 63-73 6736083-3 1984 The labeled antifibrinogen IgG was shown to react specifically with fibrinogen adsorbed and immobilized (by glutaraldehyde) on Cuprophane. Glutaral 108-122 fibrinogen beta chain Homo sapiens 16-26 6736083-3 1984 The labeled antifibrinogen IgG was shown to react specifically with fibrinogen adsorbed and immobilized (by glutaraldehyde) on Cuprophane. cuprammonium cellulose 127-137 fibrinogen beta chain Homo sapiens 16-26 6736083-5 1984 The presence of blood cells such as platelets and granulocytes with fibrinogen on Cuprophane reduced only slightly the uptake of 125I- antifibrinogen -IgG. cuprammonium cellulose 82-92 fibrinogen beta chain Homo sapiens 68-78 6736083-5 1984 The presence of blood cells such as platelets and granulocytes with fibrinogen on Cuprophane reduced only slightly the uptake of 125I- antifibrinogen -IgG. Iodine-125 129-133 fibrinogen beta chain Homo sapiens 68-78 6736083-6 1984 The examination of fibrinogen-fibrin deposition on clinically used Cuprophane by this technique and by autoradiography of the same material following 125I- antifibrinogen -IgG conjugation indicated that the deposition of fibrinogen was heavy and heterogeneous. cuprammonium cellulose 67-77 fibrinogen beta chain Homo sapiens 19-29 6723060-0 1984 Isolation of human fibrinogen using nitroblue tetrazolium (NBT). Nitroblue Tetrazolium 36-57 fibrinogen beta chain Homo sapiens 19-29 6723060-0 1984 Isolation of human fibrinogen using nitroblue tetrazolium (NBT). Nitroblue Tetrazolium 59-62 fibrinogen beta chain Homo sapiens 19-29 6705791-6 1984 Aggregation and adenine nucleotide secretion induced by 1-O-alkylAcGEPC can be observed in the absence of added fibrinogen, but addition of fibrinogen causes a very marked shift to the left in the dose/response curves for aggregation and Ca2+ uptake induced by 1-O-alkylAcGEPC. 1-o-alkylacgepc 56-71 fibrinogen beta chain Homo sapiens 112-122 6705791-6 1984 Aggregation and adenine nucleotide secretion induced by 1-O-alkylAcGEPC can be observed in the absence of added fibrinogen, but addition of fibrinogen causes a very marked shift to the left in the dose/response curves for aggregation and Ca2+ uptake induced by 1-O-alkylAcGEPC. 1-o-alkylacgepc 261-276 fibrinogen beta chain Homo sapiens 140-150 6705791-9 1984 Adrenaline induces Ca2+ uptake only into stirred human platelets in the presence of added fibrinogen. Epinephrine 0-10 fibrinogen beta chain Homo sapiens 90-100 6421970-5 1984 Studies of the mechanism by which iron prevents a normal plasma coagulation revealed that the proenzymes of the coagulation cascade and fibrinogen were not damaged by iron. Iron 34-38 fibrinogen beta chain Homo sapiens 136-146 6421970-7 1984 Instead, thrombin was markedly inhibited by iron in its clotting effect on fibrinogen and, specifically, in its fibrinopeptide A-generating capacity, the inhibitory effect being reversible upon iron removal by EDTA chelation and gel filtration. Iron 44-48 fibrinogen beta chain Homo sapiens 75-85 6719396-1 1984 By quantitative phosphorus determination on the single chains of human fibrinogen it is demonstrated that the covalently bound phosphorus of adult and fetal fibrinogen is exclusively located in the A alpha chain. Phosphorus 16-26 fibrinogen beta chain Homo sapiens 71-81 6719396-1 1984 By quantitative phosphorus determination on the single chains of human fibrinogen it is demonstrated that the covalently bound phosphorus of adult and fetal fibrinogen is exclusively located in the A alpha chain. Phosphorus 16-26 fibrinogen beta chain Homo sapiens 157-167 6719396-1 1984 By quantitative phosphorus determination on the single chains of human fibrinogen it is demonstrated that the covalently bound phosphorus of adult and fetal fibrinogen is exclusively located in the A alpha chain. Phosphorus 127-137 fibrinogen beta chain Homo sapiens 71-81 6719396-1 1984 By quantitative phosphorus determination on the single chains of human fibrinogen it is demonstrated that the covalently bound phosphorus of adult and fetal fibrinogen is exclusively located in the A alpha chain. Phosphorus 127-137 fibrinogen beta chain Homo sapiens 157-167 6719396-2 1984 The A alpha-chain of fetal fibrinogen contains about twice as much phosphorus as the adult A alpha-chain in the well known position of Ser 3 of fibrino-peptide A as well as in a hitherto unknown second position on the A alpha-chain. Phosphorus 67-77 fibrinogen beta chain Homo sapiens 27-37 6719396-3 1984 By consecutive cleavage of the A alpha-chains of fetal and adult fibrinogen with cyanogen bromide, trypsin, and chymotrypsin, separation of the resulting peptide mixtures and analysis for phosphorylated amino acids, this second phosphorylation site could be traced to Ser 345 of the A alpha-chain. Cyanogen Bromide 81-97 fibrinogen beta chain Homo sapiens 65-75 6719396-4 1984 There is only one sequence homology between the two now known in vivo phosphorylation sites of human fibrinogen, namely that the second amino acid to the carboxyl side of the phosphorylated Ser is Glu. Serine 190-193 fibrinogen beta chain Homo sapiens 101-111 6719396-4 1984 There is only one sequence homology between the two now known in vivo phosphorylation sites of human fibrinogen, namely that the second amino acid to the carboxyl side of the phosphorylated Ser is Glu. Glutamic Acid 197-200 fibrinogen beta chain Homo sapiens 101-111 6230229-3 1984 We have used a photoactivable bifunctional reagent, N-succinimidyl-6-(4"-azido-2"-nitrophenylamino)hexanoate, SANAH, to derivatize 125I-labeled-fibrinogen (125I-Fg) and crosslink it to ADP-stimulated platelets. N-succinimidyl-6-(4'-azido-2'-nitrophenylamino)hexanoate 52-108 fibrinogen beta chain Homo sapiens 144-154 6230229-3 1984 We have used a photoactivable bifunctional reagent, N-succinimidyl-6-(4"-azido-2"-nitrophenylamino)hexanoate, SANAH, to derivatize 125I-labeled-fibrinogen (125I-Fg) and crosslink it to ADP-stimulated platelets. sanah 110-115 fibrinogen beta chain Homo sapiens 144-154 6229546-6 1984 The presence of fibrinogen, beta TG, and PF4 in corresponding large intracellular vacuoles and along the platelet plasma membrane after thrombin stimulation was demonstrated by immunocytochemical techniques in saponin-permeabilized and nonpermeabilized platelets. Saponins 210-217 fibrinogen beta chain Homo sapiens 16-26 6085852-1 1984 Fluorescamine-labelled human fibrinogen was degraded with trypsin. Fluorescamine 0-13 fibrinogen beta chain Homo sapiens 29-39 6592941-0 1984 Ex vivo effects of ticlopidine on human platelets: inhibition of fibrinogen binding by a mechanism independent of thromboxane formation. Ticlopidine 19-30 fibrinogen beta chain Homo sapiens 65-75 6197944-5 1984 Coagulation variables were similar, but prothrombin and partial thromboplastin times were higher 12 hours postoperatively and fibrinogen level was lower 7 days postoperatively in the patients receiving HES. Hydroxyethyl Starch Derivatives 202-205 fibrinogen beta chain Homo sapiens 126-136 6689949-1 1984 Accelerated fibrinogen disappearance in diabetic patients is reversible with normalization of blood glucose. Blood Glucose 94-107 fibrinogen beta chain Homo sapiens 12-22 6100105-2 1984 We found that antisera raised in rabbits against membranes prepared from human intact, chymotrypsin- or pronase-treated platelets inhibited the fibrinogen-induced aggregations of ADP-stimulated intact platelets, chymotrypsin-treated platelets and pronase-treated platelets. Adenosine Diphosphate 179-182 fibrinogen beta chain Homo sapiens 144-154 6100105-3 1984 These antisera also blocked the binding of 125I-fibrinogen to ADP-stimulated intact, chymotrypsin-treated, and pronase-treated platelets. Adenosine Diphosphate 62-65 fibrinogen beta chain Homo sapiens 48-58 6100105-10 1984 It is proposed that the 66 000 Mr protein may be the fibrinogen binding domain of GPIII which becomes permanently exposed on the surface of chymotrypsin and pronase-treated platelets following proteolysis and which becomes exposed upon stimulation of intact platelets by agents such as ADP. Adenosine Diphosphate 286-289 fibrinogen beta chain Homo sapiens 53-63 6323960-1 1984 Adenosine diphosphate (ADP) is known to induce platelet shape change, aggregation and fibrinogen binding, followed by secretion. Adenosine Diphosphate 0-21 fibrinogen beta chain Homo sapiens 86-96 6323960-1 1984 Adenosine diphosphate (ADP) is known to induce platelet shape change, aggregation and fibrinogen binding, followed by secretion. Adenosine Diphosphate 23-26 fibrinogen beta chain Homo sapiens 86-96 6323960-4 1984 FSBA (5"-p-fluorosulfonylbenzoyl adenosine) covalently modifies a single protein in intact platelets with Mr = 100 000 and concomitantly inhibits platelet shape change, aggregation and fibrinogen binding. 5'-(4-fluorosulfonylbenzoyl)adenosine 6-42 fibrinogen beta chain Homo sapiens 185-195 6323960-9 1984 The ability of FSBA to inhibit platelet aggregation and fibrinogen binding by prostaglandin H2 derivatives and epinephrine suggest that ADP is involved in these processes. Prostaglandin H2 78-94 fibrinogen beta chain Homo sapiens 56-66 6323960-9 1984 The ability of FSBA to inhibit platelet aggregation and fibrinogen binding by prostaglandin H2 derivatives and epinephrine suggest that ADP is involved in these processes. Adenosine Diphosphate 136-139 fibrinogen beta chain Homo sapiens 56-66 6512326-5 1984 While placing her on replacement and adjunctive therapies the laboratory tests were performed serially, which permitted a close follow-up observation of the subsequent progress of DIC with the detection of lowered platelet counts and fibrinogen levels as administration of Heparin resulted in an increase in the amount of bleeding, FOY, 800mg/day, was instituted and following this treatment the DIC disappeared. Heparin 273-280 fibrinogen beta chain Homo sapiens 234-244 6430306-0 1984 Fibrinogen degradation products influence PGI2 synthesis by cultured porcine aortic endothelial and smooth muscle cells. Epoprostenol 42-46 fibrinogen beta chain Homo sapiens 0-10 6430306-4 1984 PGI2 synthesis by cultured smooth muscle cells incubated with fibrinogen degradation products (FDPs) for 24 h decreased. Epoprostenol 0-4 fibrinogen beta chain Homo sapiens 62-72 6430888-1 1984 Human plasma fibrinogen rapidly incorporated stoichiometric amounts of [32P]-phosphate when incubated with [32P]ATP and calcium-activated, phospholipid-dependent protein kinase purified from pig spleen. Phosphorus-32 72-77 fibrinogen beta chain Homo sapiens 13-23 6430888-1 1984 Human plasma fibrinogen rapidly incorporated stoichiometric amounts of [32P]-phosphate when incubated with [32P]ATP and calcium-activated, phospholipid-dependent protein kinase purified from pig spleen. Phosphates 77-86 fibrinogen beta chain Homo sapiens 13-23 6430888-1 1984 Human plasma fibrinogen rapidly incorporated stoichiometric amounts of [32P]-phosphate when incubated with [32P]ATP and calcium-activated, phospholipid-dependent protein kinase purified from pig spleen. Phosphorus-32 72-75 fibrinogen beta chain Homo sapiens 13-23 6430888-1 1984 Human plasma fibrinogen rapidly incorporated stoichiometric amounts of [32P]-phosphate when incubated with [32P]ATP and calcium-activated, phospholipid-dependent protein kinase purified from pig spleen. Adenosine Triphosphate 112-115 fibrinogen beta chain Homo sapiens 13-23 6430888-2 1984 Half-maximal fibrinogen kinase activity was attained at less than 0.1 mM calcium acetate. calcium acetate 73-88 fibrinogen beta chain Homo sapiens 13-23 6430888-5 1984 The alpha-chain of fibrinogen, which is reported to contain endogenous phosphate (Blomback, B., Blomback, M., Edman, P., & Hessel, B. Phosphates 71-80 fibrinogen beta chain Homo sapiens 19-29 6430888-7 1984 The apparent Km value for the phosphorylation reaction (0.3-0.6 microM fibrinogen) was comparable with the Km values reported for the hitherto most effective substrate proteins for protein kinase C. Up to 5 mol phosphate per mol fibrinogen could be incorporated, indicating at least three phosphorylatable sites per half molecule. Phosphates 211-220 fibrinogen beta chain Homo sapiens 71-81 6729777-4 1984 Treatment of plasma with neuraminidase largely abolished the inhibitory effect of excess citrate, and the thrombin times and clot opacity of asialofibrinogen were less affected by citrate than native fibrinogen. Citric Acid 180-187 fibrinogen beta chain Homo sapiens 147-157 6729777-5 1984 In addition, the effects of citrate on the clotting of purified, calcium-free fibrinogen from cirrhotic patients correlated with the sialic acid content. Citric Acid 28-35 fibrinogen beta chain Homo sapiens 78-88 6729777-5 1984 In addition, the effects of citrate on the clotting of purified, calcium-free fibrinogen from cirrhotic patients correlated with the sialic acid content. Calcium 65-72 fibrinogen beta chain Homo sapiens 78-88 6729777-5 1984 In addition, the effects of citrate on the clotting of purified, calcium-free fibrinogen from cirrhotic patients correlated with the sialic acid content. N-Acetylneuraminic Acid 133-144 fibrinogen beta chain Homo sapiens 78-88 6729777-6 1984 It is concluded that binding of citrate ions to fibrinogen renders the molecule acutely more sensitive to elevations in the sialic acid content, and that a simple plasma clot opacity test in the presence of excess citrate may be a useful aid in the differential diagnosis of liver disease. Citric Acid 32-39 fibrinogen beta chain Homo sapiens 48-58 6729777-6 1984 It is concluded that binding of citrate ions to fibrinogen renders the molecule acutely more sensitive to elevations in the sialic acid content, and that a simple plasma clot opacity test in the presence of excess citrate may be a useful aid in the differential diagnosis of liver disease. N-Acetylneuraminic Acid 124-135 fibrinogen beta chain Homo sapiens 48-58 6377566-3 1984 The enzyme so purified readily degraded fibrin, fibrinogen, elastin and -Val type synthetic peptide substrates, such as Suc-L-Ala-L-Tyr-L-Leu-L-Val-pNA and Suc-L-Tyr-L-Leu-L-Val-pNA. Suc-L-Ala-L-Tyr-L-Leu-L-Val-pNA 120-151 fibrinogen beta chain Homo sapiens 48-58 6377566-3 1984 The enzyme so purified readily degraded fibrin, fibrinogen, elastin and -Val type synthetic peptide substrates, such as Suc-L-Ala-L-Tyr-L-Leu-L-Val-pNA and Suc-L-Tyr-L-Leu-L-Val-pNA. Suc-L-Tyr-L-Leu-L-Val-pNA 156-181 fibrinogen beta chain Homo sapiens 48-58 6740546-1 1984 Fixed platelets, bearing covalently bound fibrinogen, were previously shown to participate passively in aggregation induced by thrombin or A23187. Calcimycin 139-145 fibrinogen beta chain Homo sapiens 42-52 6740548-2 1984 Both tracers originated from a common pool of beta-alanine precipitated fibrinogen. beta-Alanine 46-58 fibrinogen beta chain Homo sapiens 72-82 6740550-3 1984 Reexamination of the ability of hemoglobin to inhibit the adsorption of 125I fibrinogen to polyethylene revealed that the inhibition was strongly dependent on the fibrinogen concentration. Polyethylene 91-103 fibrinogen beta chain Homo sapiens 77-87 6740550-3 1984 Reexamination of the ability of hemoglobin to inhibit the adsorption of 125I fibrinogen to polyethylene revealed that the inhibition was strongly dependent on the fibrinogen concentration. Polyethylene 91-103 fibrinogen beta chain Homo sapiens 163-173 6711637-2 1984 Iodine 125-labeled fibrinogen leg counting, to diagnose deep venous thrombosis, was performed daily. Iodine 0-6 fibrinogen beta chain Homo sapiens 19-29 6711637-9 1984 Two patients with no evidence of deep venous thrombosis on prospective 125I-labeled fibrinogen leg counting developed pulmonary emboli, including one fatal pulmonary embolus that was found at autopsy to have arisen from the internal iliac veins. Iodine-125 71-75 fibrinogen beta chain Homo sapiens 84-94 6324004-6 1984 To test this hypothesis, we have examined ADP- and thrombin-supported 125I-vWF binding to platelets in the plasma of severe vWD patients, and report here that it is inhibited by fibrinogen. Adenosine Diphosphate 42-45 fibrinogen beta chain Homo sapiens 178-188 6324004-7 1984 Thus, in addition to its role in coagulation and platelet aggregation, fibrinogen influences the binding of vWF to thrombin- and ADP-stimulated platelets. Adenosine Diphosphate 129-132 fibrinogen beta chain Homo sapiens 71-81 6326808-2 1984 Binding of fibrinogen to human platelets depends on the interaction of the gamma-chain carboxy-terminal segment with specific receptors exposed by different agonists such as ADP, epinephrine, and thrombin. Adenosine Diphosphate 174-177 fibrinogen beta chain Homo sapiens 11-21 6326808-2 1984 Binding of fibrinogen to human platelets depends on the interaction of the gamma-chain carboxy-terminal segment with specific receptors exposed by different agonists such as ADP, epinephrine, and thrombin. Epinephrine 179-190 fibrinogen beta chain Homo sapiens 11-21 6326808-4 1984 Both pentadecapeptide (gamma 397-411) and dodecapeptide (gamma 400-411) inhibited binding of 125I-fibrinogen to ADP-treated platelets, with the concentration causing 50% inhibition (IC50) being 28 microM. Adenosine Diphosphate 112-115 fibrinogen beta chain Homo sapiens 98-108 6712666-1 1984 Purified platelet thrombospondin binds to immobilized fibrinogen if both Ca++ and Mg++ are present. Magnesium 82-86 fibrinogen beta chain Homo sapiens 54-64 6712666-3 1984 When such digests are subjected to affinity chromatography on immobilized fibrinogen, only the fragments with Mr of 120,000 and 140,000 are specifically bound and subsequently eluted by the addition of EDTA to the column buffer. Edetic Acid 202-206 fibrinogen beta chain Homo sapiens 74-84 6712666-4 1984 Examination by SDS-PAGE under both reducing and nonreducing conditions reveals that the fibrinogen-binding domain is derived from the region of the thrombospondin molecule containing the interchain disulfide bonds. Sodium Dodecyl Sulfate 15-18 fibrinogen beta chain Homo sapiens 88-98 6712666-4 1984 Examination by SDS-PAGE under both reducing and nonreducing conditions reveals that the fibrinogen-binding domain is derived from the region of the thrombospondin molecule containing the interchain disulfide bonds. Disulfides 198-207 fibrinogen beta chain Homo sapiens 88-98 6712666-5 1984 The requirement for Ca++ and Mg++ for optimal binding to fibrinogen is also manifest by the Mr 120,000/140,000 thermolytic fragments. Magnesium 29-33 fibrinogen beta chain Homo sapiens 57-67 6698031-2 1984 Highly purified human fibrinogen was labelled with radioactive iodine and its interaction with cultured human embryo lung fibroblasts (MRC5) was examined. radioactive iodine 51-69 fibrinogen beta chain Homo sapiens 22-32 6698031-3 1984 The cell monolayer was incubated at 37 degrees C with 125I-fibrinogen in phosphate/saline buffer containing 1 mM Ca2+ and 1 mM Mg2+. Phosphates 73-82 fibrinogen beta chain Homo sapiens 59-69 6696949-2 1984 Plasma fibrinogen was separated by ion exchange chromatography on DEAE-Sephacel into three populations of molecules, each with a unique gamma-chain composition. deae-sephacel 66-79 fibrinogen beta chain Homo sapiens 7-17 6232725-2 1984 showed that over 1 mM dithiothreitol (DTT) aggregates blood platelets in the presence of fibrinogen; aggregation is not inhibited by prostaglandin E1. Dithiothreitol 22-36 fibrinogen beta chain Homo sapiens 89-99 6232725-2 1984 showed that over 1 mM dithiothreitol (DTT) aggregates blood platelets in the presence of fibrinogen; aggregation is not inhibited by prostaglandin E1. Dithiothreitol 38-41 fibrinogen beta chain Homo sapiens 89-99 6232725-6 1984 Platelets stimulated with DTT bound 125I-labeled fibrinogen. Dithiothreitol 26-29 fibrinogen beta chain Homo sapiens 49-59 6232725-7 1984 Thus DTT appears to "expose" the fibrinogen receptors. Dithiothreitol 5-8 fibrinogen beta chain Homo sapiens 33-43 6719392-2 1984 Fibrinogen was prepared from a lysate of normal human platelets by ethanol precipitation and by antifibrinogen immunoaffinity chromatography. Ethanol 67-74 fibrinogen beta chain Homo sapiens 0-10 6731953-5 1984 Sensitive and specific tests are the assays for fibrinogen-fibrin degradation products (FDP) and soluble complexes (SC) using the haemagglutination test or the ethanol test. Ethanol 160-167 fibrinogen beta chain Homo sapiens 48-58 6704329-4 1984 Isoelectric focussing (IEF) of the reduced patient"s fibrinogen in urea/polyacrylamide gel revealed minor components with higher isoelectric points (pI) than present in normal fibrinogen or fibrin. Urea 67-71 fibrinogen beta chain Homo sapiens 53-63 6704329-4 1984 Isoelectric focussing (IEF) of the reduced patient"s fibrinogen in urea/polyacrylamide gel revealed minor components with higher isoelectric points (pI) than present in normal fibrinogen or fibrin. polyacrylamide 72-86 fibrinogen beta chain Homo sapiens 53-63 6698629-3 1984 The modified fibrinogen is then labeled with [111In]acetate, with an average yield of 90 +/- 3%. [111in]acetate 45-59 fibrinogen beta chain Homo sapiens 13-23 6531574-0 1984 [Detection of venous thrombosis of the legs by the iodine 125-labeled fibrinogen test in thoracic surgery. Iodine-125 51-61 fibrinogen beta chain Homo sapiens 70-80 6531574-2 1984 The tracing of venous thromboses of the lower limbs by means of iodine 125 marked fibrinogen is possible in thoracic surgery thanks to the calibration of the apparatus on the femoral surface in cases of left thoracotomy or sternotomy. Iodine 64-70 fibrinogen beta chain Homo sapiens 82-92 6523367-2 1984 At the same time the patients demonstrate high concentration of sterols bound by fibrinogen, a considerable lowering of cholesterol content in high density lipoproteins having an antiiatrogenic action. Sterols 64-71 fibrinogen beta chain Homo sapiens 81-91 6523367-2 1984 At the same time the patients demonstrate high concentration of sterols bound by fibrinogen, a considerable lowering of cholesterol content in high density lipoproteins having an antiiatrogenic action. Cholesterol 120-131 fibrinogen beta chain Homo sapiens 81-91 6320488-1 1983 Platelets deprived of calcium and incubated at 37 degrees C for 10 min lose their ability to bind fibrinogen or aggregate with ADP when adequate concentrations of calcium are restored. Calcium 22-29 fibrinogen beta chain Homo sapiens 98-108 6607549-0 1984 Does qualitatively altered fibrinogen contribute to the increased heparin precipitable fraction (HPF) in acute myocardial infarction (AMI)? Heparin 66-73 fibrinogen beta chain Homo sapiens 27-37 6320488-2 1983 Since the calcium complex of glycoproteins (GP) IIb and IIIa is the presumed receptor for fibrinogen, it seemed appropriate to examine the behavior of these glycoproteins in incubated nonaggregable platelets. Calcium 10-17 fibrinogen beta chain Homo sapiens 90-100 6318767-2 1983 Maximal incorporation averaged 4 mol of phosphate per mol of fibrinogen, most of it in the largest CNBr-fragment of the alpha-chain. Phosphates 40-49 fibrinogen beta chain Homo sapiens 61-71 6661434-4 1983 Furthermore, the time course of release, in relation to that of fibrinopeptide A, suggested that some des-A-fibrinogen species (e.g., alpha 2B beta 2 gamma 2) may be the true activator for promoting the cleavage of the Arg-36 peptide bonds in the a subunits of factor XIII. Arginine 219-222 fibrinogen beta chain Homo sapiens 108-118 6315695-1 1983 Hep-G2 cells, pulse-labeled with L-[35S]methionine, incorporate radioactivity within 2 min into precursor forms of fibrinogen and into fibrinogen. L-Methionine-35S 33-50 fibrinogen beta chain Homo sapiens 115-125 6315695-1 1983 Hep-G2 cells, pulse-labeled with L-[35S]methionine, incorporate radioactivity within 2 min into precursor forms of fibrinogen and into fibrinogen. L-Methionine-35S 33-50 fibrinogen beta chain Homo sapiens 135-145 6358210-3 1983 A binding defect of Thrombin Quick toward fibrinogen is indicated by an increased KI when fibrinogen is present as a competitive inhibitor in the hydrolysis of tosyl-Gly-Pro-Arg-p-nitroanilide. tosyl-gly-pro-arg-p-nitroanilide 160-192 fibrinogen beta chain Homo sapiens 42-52 6315695-4 1983 Following a pulse-chase incubation with L-[35S]methionine, the radioactive composition of newly secreted fibrinogen also reflects the fact that there is a large intracellular pool of gamma chains. L-Methionine-35S 40-57 fibrinogen beta chain Homo sapiens 105-115 6358210-3 1983 A binding defect of Thrombin Quick toward fibrinogen is indicated by an increased KI when fibrinogen is present as a competitive inhibitor in the hydrolysis of tosyl-Gly-Pro-Arg-p-nitroanilide. tosyl-gly-pro-arg-p-nitroanilide 160-192 fibrinogen beta chain Homo sapiens 90-100 6658718-4 1983 However, the phosphorus content of cord fibrinogen was 3-4 times higher than that of adult fibrinogen. Phosphorus 13-23 fibrinogen beta chain Homo sapiens 40-50 6656769-3 1983 Also, and mot importantly, cross-reactivity was observed with fibrinogen-free ethanol extracts of plasma obtained from patients known to contain high levels of fibrinogen or fibrin degradation products. Ethanol 78-85 fibrinogen beta chain Homo sapiens 62-72 6656769-3 1983 Also, and mot importantly, cross-reactivity was observed with fibrinogen-free ethanol extracts of plasma obtained from patients known to contain high levels of fibrinogen or fibrin degradation products. Ethanol 78-85 fibrinogen beta chain Homo sapiens 160-170 6658718-5 1983 The accelerating effect of calcium on the thrombin clotting time was more pronounced for newborn cord plasma and for purified cord fibrinogen preparations as compared with adult fibrinogen. Calcium 27-34 fibrinogen beta chain Homo sapiens 131-141 6658718-5 1983 The accelerating effect of calcium on the thrombin clotting time was more pronounced for newborn cord plasma and for purified cord fibrinogen preparations as compared with adult fibrinogen. Calcium 27-34 fibrinogen beta chain Homo sapiens 178-188 6417869-7 1983 Twenty parts of fibrinogen to one part of 10 per cent calcium chloride provided the shortest generation time and the greatest tensile strength in each of the experiments, and is used exclusively by the authors at present. Calcium Chloride 54-70 fibrinogen beta chain Homo sapiens 16-26 6658718-6 1983 This might be explained by the higher phosphorus content of the cord fibrinogen molecule. Phosphorus 38-48 fibrinogen beta chain Homo sapiens 69-79 6672296-0 1983 [Measurement of fibrinogen in heparinized plasma using Polybrene]. Hexadimethrine Bromide 55-64 fibrinogen beta chain Homo sapiens 16-26 6648427-5 1983 It is therefore concluded that fibrinogen Bern II undergoes substitution of arginine in position 16 of the A alpha-chain by histidine. Arginine 76-84 fibrinogen beta chain Homo sapiens 31-41 6648427-5 1983 It is therefore concluded that fibrinogen Bern II undergoes substitution of arginine in position 16 of the A alpha-chain by histidine. Histidine 124-133 fibrinogen beta chain Homo sapiens 31-41 6640056-2 1983 The adhesion force between a reference surface (glass) and different polymers (polyurethanes and cellulose derivatives) was found to be dependent on the immersion time of polymers in electrolyte and on the formation of adsorption layers of serum albumin and fibrinogen. Polymers 69-77 fibrinogen beta chain Homo sapiens 258-268 6640056-2 1983 The adhesion force between a reference surface (glass) and different polymers (polyurethanes and cellulose derivatives) was found to be dependent on the immersion time of polymers in electrolyte and on the formation of adsorption layers of serum albumin and fibrinogen. Polyurethanes 79-92 fibrinogen beta chain Homo sapiens 258-268 6640056-2 1983 The adhesion force between a reference surface (glass) and different polymers (polyurethanes and cellulose derivatives) was found to be dependent on the immersion time of polymers in electrolyte and on the formation of adsorption layers of serum albumin and fibrinogen. Cellulose 97-106 fibrinogen beta chain Homo sapiens 258-268 6618271-4 1983 The increased fibrinogen deposition is abolished by treatment with low dose heparin. Heparin 76-83 fibrinogen beta chain Homo sapiens 14-24 6309797-2 1983 Fibrinogen binding to platelet plasma membranes, which is a prerequisite for platelet aggregation, was determined by incubating 125I-labeled fibrinogen with isolated membranes and measuring the amount of radioactivity sedimenting with the membranes through 15% sucrose. Iodine-125 128-132 fibrinogen beta chain Homo sapiens 0-10 6309797-5 1983 The data in the present study suggest that there are two divalent cation binding sites that must be occupied for fibrinogen to bind: one site is specific for calcium and is saturated at 10(-6) M Ca2+; the other site is less specific and is saturated at a 10(-3) M concentration of either Ca2+ or Mg2+. Calcium 158-165 fibrinogen beta chain Homo sapiens 113-123 6411843-4 1983 Hematin in a final concentration of 0.01 mg/ml inhibited the clotting of bovine fibrinogen (1.3 to 2.6 mg/ml) by bovine thrombin (0.12 U/ml) and inhibited the hydrolysis of a synthetic substrate by human thrombin. Hemin 0-7 fibrinogen beta chain Homo sapiens 80-90 6626500-3 1983 The Michaelis-Menten parameters for the hydrolysis of the Arg-Gly bond in F-8 by thrombin were determined to be Kcat = 31 X 10(-11) M [(NIH unit/L) s]-1 and KM = 310 X 10(-6) M. Comparison of these values with those determined previously for native fibrinogen and for a series of similar synthetic peptides, together with information about the amino acid sequences of this portion of the A alpha chain of abnormal fibrinogens, suggests an important role for Asp at position P10. Arginine 58-61 fibrinogen beta chain Homo sapiens 249-259 6626500-3 1983 The Michaelis-Menten parameters for the hydrolysis of the Arg-Gly bond in F-8 by thrombin were determined to be Kcat = 31 X 10(-11) M [(NIH unit/L) s]-1 and KM = 310 X 10(-6) M. Comparison of these values with those determined previously for native fibrinogen and for a series of similar synthetic peptides, together with information about the amino acid sequences of this portion of the A alpha chain of abnormal fibrinogens, suggests an important role for Asp at position P10. Glycine 62-65 fibrinogen beta chain Homo sapiens 249-259 6504946-4 1984 The results showed that in the hydroxychloroquine-treated group the transoperative increase in fibrinogen was associated with a reduction in plasma viscosity compared with an increase in the control group. Hydroxychloroquine 31-49 fibrinogen beta chain Homo sapiens 95-105 6224505-4 1983 In functional assays these two antibodies could specifically inhibit ADP and collagen induced aggregation of platelets and release of ATP, retard platelet aggregation and ATP release induced by epinephrine, and inhibit ADP induced platelet fibrinogen binding. Adenosine Diphosphate 69-72 fibrinogen beta chain Homo sapiens 240-250 6224505-4 1983 In functional assays these two antibodies could specifically inhibit ADP and collagen induced aggregation of platelets and release of ATP, retard platelet aggregation and ATP release induced by epinephrine, and inhibit ADP induced platelet fibrinogen binding. Adenosine Diphosphate 219-222 fibrinogen beta chain Homo sapiens 240-250 6636032-1 1983 Fibrinogen plays an integral part in ADP-induced platelet aggregation. Adenosine Diphosphate 37-40 fibrinogen beta chain Homo sapiens 0-10 6636032-6 1983 These fibrinogen fractions equally promoted ADP-induced platelet aggregation. Adenosine Diphosphate 44-47 fibrinogen beta chain Homo sapiens 6-16 6309797-2 1983 Fibrinogen binding to platelet plasma membranes, which is a prerequisite for platelet aggregation, was determined by incubating 125I-labeled fibrinogen with isolated membranes and measuring the amount of radioactivity sedimenting with the membranes through 15% sucrose. Iodine-125 128-132 fibrinogen beta chain Homo sapiens 141-151 6309797-2 1983 Fibrinogen binding to platelet plasma membranes, which is a prerequisite for platelet aggregation, was determined by incubating 125I-labeled fibrinogen with isolated membranes and measuring the amount of radioactivity sedimenting with the membranes through 15% sucrose. Sucrose 261-268 fibrinogen beta chain Homo sapiens 0-10 6309797-5 1983 The data in the present study suggest that there are two divalent cation binding sites that must be occupied for fibrinogen to bind: one site is specific for calcium and is saturated at 10(-6) M Ca2+; the other site is less specific and is saturated at a 10(-3) M concentration of either Ca2+ or Mg2+. magnesium ion 296-300 fibrinogen beta chain Homo sapiens 113-123 6309797-7 1983 These data indicate that the cytoplasm is a potential source for the requirement of 10(-6) M Ca2+, and that changes in the intracellular concentration of Ca2+ may cause the expression of fibrinogen receptors during ADP-induced platelet activation. Adenosine Diphosphate 215-218 fibrinogen beta chain Homo sapiens 187-197 6347123-3 1983 We found no significant difference in the incidence of thromboembolism between the two groups but a higher incidence of abnormal fibrinogen uptake test results in patients given heparin alone. Heparin 178-185 fibrinogen beta chain Homo sapiens 129-139 20217997-1 1983 Most plasma fibrinogen molecules, when analyzed by Na Dod SO4 polyacrylamide gel electrophoresis migrate in three major positions, designated bands I, II, and III, respectively. na dod so4 51-61 fibrinogen beta chain Homo sapiens 12-22 20217997-1 1983 Most plasma fibrinogen molecules, when analyzed by Na Dod SO4 polyacrylamide gel electrophoresis migrate in three major positions, designated bands I, II, and III, respectively. polyacrylamide 62-76 fibrinogen beta chain Homo sapiens 12-22 20217998-0 1983 Fibrinogen interaction with human platelets: effect of other coagulation factors, prostaglandins and platelet inhibitors. Prostaglandins 82-96 fibrinogen beta chain Homo sapiens 0-10 20218004-1 1983 Isoelectric focussing (IEF) in 6M urea/4% polyacrylamide gel of reduced human fibrinogen and the fibrins formed by reptilase and thrombin gave a complex multibanded pattern. Urea 34-38 fibrinogen beta chain Homo sapiens 78-88 20218004-1 1983 Isoelectric focussing (IEF) in 6M urea/4% polyacrylamide gel of reduced human fibrinogen and the fibrins formed by reptilase and thrombin gave a complex multibanded pattern. polyacrylamide 42-56 fibrinogen beta chain Homo sapiens 78-88 6636042-0 1983 Comparative study of the iodination of tyrosines in the amino terminal domain of fibrinogen and in N-DSK and fibrin-N-DSK. Tyrosine 39-48 fibrinogen beta chain Homo sapiens 81-91 6636042-1 1983 Lactoperoxidase catalyzed iodination has been used to probe for differences in surface orientation of tyrosine residues in the amino-terminal disulfide knot (N-DSK) domain of fibrinogen, in N-DSK and in Fb-N-DSK prepared from fibrin. Tyrosine 102-110 fibrinogen beta chain Homo sapiens 175-185 6636042-1 1983 Lactoperoxidase catalyzed iodination has been used to probe for differences in surface orientation of tyrosine residues in the amino-terminal disulfide knot (N-DSK) domain of fibrinogen, in N-DSK and in Fb-N-DSK prepared from fibrin. Disulfides 142-151 fibrinogen beta chain Homo sapiens 175-185 6863272-4 1983 Photooxidation of the activated NH2-terminal disulfide knot, which is derived from fibrin and contains the NH2-terminal binding domain, reduced the ability of this fragment to bind to fibrinogen-Sepharose conjugate. Disulfides 45-54 fibrinogen beta chain Homo sapiens 184-194 6863272-4 1983 Photooxidation of the activated NH2-terminal disulfide knot, which is derived from fibrin and contains the NH2-terminal binding domain, reduced the ability of this fragment to bind to fibrinogen-Sepharose conjugate. Sepharose 195-204 fibrinogen beta chain Homo sapiens 184-194 6629526-3 1983 In vitro studies with 125I-labeled human fibrinogen or immunoglobulin G (IgG) showed that the adsorption of fibrinogen or IgG was greater on polyacrylonitrile than on Cuprophane. Iodine-125 22-26 fibrinogen beta chain Homo sapiens 41-51 6629526-3 1983 In vitro studies with 125I-labeled human fibrinogen or immunoglobulin G (IgG) showed that the adsorption of fibrinogen or IgG was greater on polyacrylonitrile than on Cuprophane. Iodine-125 22-26 fibrinogen beta chain Homo sapiens 108-118 6629526-3 1983 In vitro studies with 125I-labeled human fibrinogen or immunoglobulin G (IgG) showed that the adsorption of fibrinogen or IgG was greater on polyacrylonitrile than on Cuprophane. polyacrylonitrile 141-158 fibrinogen beta chain Homo sapiens 108-118 6629526-3 1983 In vitro studies with 125I-labeled human fibrinogen or immunoglobulin G (IgG) showed that the adsorption of fibrinogen or IgG was greater on polyacrylonitrile than on Cuprophane. cuprammonium cellulose 167-177 fibrinogen beta chain Homo sapiens 108-118 6629526-4 1983 Further studies on the reactivity of fibrinogen adsorbed on polyacrylonitrile surface indicated that the absorbed fibrinogen: (a) was not desorbed readily from the surface, (b) was not appreciably displaced by other plasma proteins such as albumin, IgG, and fibrinogen, (c) was not readily accessible for reaction with 125I-antifibrinogen-IgG, and (d) did not promote the adhesion of 51Cr-labeled platelets. polyacrylonitrile 60-77 fibrinogen beta chain Homo sapiens 37-47 6629526-4 1983 Further studies on the reactivity of fibrinogen adsorbed on polyacrylonitrile surface indicated that the absorbed fibrinogen: (a) was not desorbed readily from the surface, (b) was not appreciably displaced by other plasma proteins such as albumin, IgG, and fibrinogen, (c) was not readily accessible for reaction with 125I-antifibrinogen-IgG, and (d) did not promote the adhesion of 51Cr-labeled platelets. polyacrylonitrile 60-77 fibrinogen beta chain Homo sapiens 114-124 6629526-4 1983 Further studies on the reactivity of fibrinogen adsorbed on polyacrylonitrile surface indicated that the absorbed fibrinogen: (a) was not desorbed readily from the surface, (b) was not appreciably displaced by other plasma proteins such as albumin, IgG, and fibrinogen, (c) was not readily accessible for reaction with 125I-antifibrinogen-IgG, and (d) did not promote the adhesion of 51Cr-labeled platelets. polyacrylonitrile 60-77 fibrinogen beta chain Homo sapiens 114-124 6629526-4 1983 Further studies on the reactivity of fibrinogen adsorbed on polyacrylonitrile surface indicated that the absorbed fibrinogen: (a) was not desorbed readily from the surface, (b) was not appreciably displaced by other plasma proteins such as albumin, IgG, and fibrinogen, (c) was not readily accessible for reaction with 125I-antifibrinogen-IgG, and (d) did not promote the adhesion of 51Cr-labeled platelets. Chromium-51 384-388 fibrinogen beta chain Homo sapiens 114-124 6629526-4 1983 Further studies on the reactivity of fibrinogen adsorbed on polyacrylonitrile surface indicated that the absorbed fibrinogen: (a) was not desorbed readily from the surface, (b) was not appreciably displaced by other plasma proteins such as albumin, IgG, and fibrinogen, (c) was not readily accessible for reaction with 125I-antifibrinogen-IgG, and (d) did not promote the adhesion of 51Cr-labeled platelets. Chromium-51 384-388 fibrinogen beta chain Homo sapiens 114-124 6629526-6 1983 On the other hand, fibrinogen and IgG augmented greatly the platelet adhesion to Cuprophane and IgG enhanced the granulocyte adhesion moderately. cuprammonium cellulose 81-91 fibrinogen beta chain Homo sapiens 19-29 6629526-7 1983 These data indicate that fibrinogen and IgG, though at high concentration on polyacrylonitrile, may adsorb in a biologically inactive form. polyacrylonitrile 77-94 fibrinogen beta chain Homo sapiens 25-35 6612696-0 1983 Thrombin clotting time and fibrinogen concentration in patients treated with coumadin. Warfarin 77-85 fibrinogen beta chain Homo sapiens 27-37 6612699-1 1983 Human fibrinogen has three calcium-binding sites. Calcium 27-34 fibrinogen beta chain Homo sapiens 6-16 6612699-3 1983 In order to investigate the possible localization of the third binding site in the central domain of fibrinogen, the amino-terminal disulphide knots (NDSK) of human fibrinogen and fibrin were prepared by cyanogen bromide degradation. disulphide 132-142 fibrinogen beta chain Homo sapiens 101-111 6612699-3 1983 In order to investigate the possible localization of the third binding site in the central domain of fibrinogen, the amino-terminal disulphide knots (NDSK) of human fibrinogen and fibrin were prepared by cyanogen bromide degradation. disulphide 132-142 fibrinogen beta chain Homo sapiens 165-175 6623990-0 1983 [Effect of phosphatidyl serine on conversion of fibrinogen to fibrin]. Phosphatidylserines 11-30 fibrinogen beta chain Homo sapiens 48-58 6623990-1 1983 Phosphatidyl serine inhibited the conversion of fibrinogen into fibrin, catalyzed by thrombin, following the pattern of coupling inhibition. Phosphatidylserines 0-19 fibrinogen beta chain Homo sapiens 48-58 6623990-3 1983 Administration of phosphatidyl serine into animal circulation led to a decrease in fibrinogen consumption, provoked by simultaneous injection of thrombin. Phosphatidylserines 18-37 fibrinogen beta chain Homo sapiens 83-93 6410532-4 1983 Although EDTA deaggregated chymotrypsin-treated platelets aggregated by fibrinogen in a medium containing a physiological concentration of Ca2+, EDTA did not deaggregate these platelets if they were in a medium without calcium in which the release reaction occurs. Edetic Acid 9-13 fibrinogen beta chain Homo sapiens 72-82 6410532-6 1983 More fibrinogen associated with platelets in the medium without calcium than in the calcium-containing medium. Calcium 64-71 fibrinogen beta chain Homo sapiens 5-15 6410532-7 1983 In both media, EDTA displaced approximately half of the fibrinogen indicating that deaggregation is not solely dependent on dissociation of fibrinogen from its receptors. Edetic Acid 15-19 fibrinogen beta chain Homo sapiens 56-66 6307105-1 1983 In summary: Incubation of platelets with ADP or proteolytic enzymes (chymotrypsin or pronase) results in an exposure of two classes of specific binding sites on platelet surface: low and high affinity fibrinogen receptors. Adenosine Diphosphate 41-44 fibrinogen beta chain Homo sapiens 201-211 6307106-1 1983 Fibrinogen participates in platelet aggregation induced by ADP and this participation is receptor mediated. Adenosine Diphosphate 59-62 fibrinogen beta chain Homo sapiens 0-10 6575678-0 1983 The plasma fibrinogen fraction with elevated sialic acid content and elongated gamma chains. N-Acetylneuraminic Acid 45-56 fibrinogen beta chain Homo sapiens 11-21 6409903-5 1983 The amino acid replacement ArgA alpha 16 leads to His present in fibrinogen Petoskey was shown to result in a 160-fold decrease in the specificity constant for hydrolysis at A alpha 16 and concomitant release of FPA. fpa 212-215 fibrinogen beta chain Homo sapiens 65-75 6849976-5 1983 In the first technique, molecular exclusion on Sephacryl S-200 superfine was utilized to examine the interaction of radiolabeled fragments with fibrinogen. sephacryl s-200 superfine 47-72 fibrinogen beta chain Homo sapiens 144-154 6849976-6 1983 In the second series of studies, fibrinogen-Sepharose was prepared and the binding of degradation products directly determined. Sepharose 44-53 fibrinogen beta chain Homo sapiens 33-43 6301579-0 1983 Exposure of fibrinogen receptors on fresh and stored platelets by ADP and epinephrine as single agents and as a pair. Adenosine Diphosphate 66-69 fibrinogen beta chain Homo sapiens 12-22 6301579-0 1983 Exposure of fibrinogen receptors on fresh and stored platelets by ADP and epinephrine as single agents and as a pair. Epinephrine 74-85 fibrinogen beta chain Homo sapiens 12-22 6301579-3 1983 Following stimulation with 10 microM ADP or 20 microM epinephrine, platelet suspensions from fresh concentrates bound 125I-fibrinogen in a reaction that reached completion within 30 min. Adenosine Diphosphate 37-40 fibrinogen beta chain Homo sapiens 123-133 6301579-3 1983 Following stimulation with 10 microM ADP or 20 microM epinephrine, platelet suspensions from fresh concentrates bound 125I-fibrinogen in a reaction that reached completion within 30 min. Epinephrine 54-65 fibrinogen beta chain Homo sapiens 123-133 6301579-4 1983 Significantly less binding occurred in suspensions from platelet concentrates that had been stored for 5 days at 22 degrees C. When stimulated by ADP and epinephrine as a pair (2 microM each), binding of fibrinogen to platelets was complete within 10-15 min and was not significantly decreased in suspensions from stored concentrates. Adenosine Diphosphate 146-149 fibrinogen beta chain Homo sapiens 204-214 6301579-4 1983 Significantly less binding occurred in suspensions from platelet concentrates that had been stored for 5 days at 22 degrees C. When stimulated by ADP and epinephrine as a pair (2 microM each), binding of fibrinogen to platelets was complete within 10-15 min and was not significantly decreased in suspensions from stored concentrates. Epinephrine 154-165 fibrinogen beta chain Homo sapiens 204-214 6301579-8 1983 We conclude that storage for 5 days at 22 degrees C impairs the exposure of fibrinogen receptors on platelets in response to ADP or epinephrine when used as single agents, without affecting the glycoprotein IIb-IIIa complex quantitatively. Adenosine Diphosphate 125-128 fibrinogen beta chain Homo sapiens 76-86 6301579-8 1983 We conclude that storage for 5 days at 22 degrees C impairs the exposure of fibrinogen receptors on platelets in response to ADP or epinephrine when used as single agents, without affecting the glycoprotein IIb-IIIa complex quantitatively. Epinephrine 132-143 fibrinogen beta chain Homo sapiens 76-86 6886584-4 1983 Fibrinogen concentrations determined chemically were significantly associated with age, smoking habit, body mass index, alcohol consumption, and intake of cereal fibre (24.2% variance). Alcohols 120-127 fibrinogen beta chain Homo sapiens 0-10 6862345-8 1983 Thus the improved effectiveness of heparin/dihydroergotamine in prevention of deep vein thrombosis which has been shown in the fibrinogen test cannot be explained by an effect onto the coagulation parameters studied. Heparin 35-42 fibrinogen beta chain Homo sapiens 127-137 6862345-8 1983 Thus the improved effectiveness of heparin/dihydroergotamine in prevention of deep vein thrombosis which has been shown in the fibrinogen test cannot be explained by an effect onto the coagulation parameters studied. Dihydroergotamine 43-60 fibrinogen beta chain Homo sapiens 127-137 6849832-0 1983 Fibrinogen Manchester: identification of an abnormal fibrinopeptide A with a C-terminal arginine leads to histidine substitution. Arginine 88-96 fibrinogen beta chain Homo sapiens 0-10 6849832-0 1983 Fibrinogen Manchester: identification of an abnormal fibrinopeptide A with a C-terminal arginine leads to histidine substitution. Histidine 106-115 fibrinogen beta chain Homo sapiens 0-10 6851280-0 1983 Heparin effect on plasma fibrinogen in the thrombophilic syndrome. Heparin 0-7 fibrinogen beta chain Homo sapiens 25-35 6851280-3 1983 Statistically significant results proved that heparin reduces the plasma fibrinogen progressively over a treatment period of 6 weeks. Heparin 46-53 fibrinogen beta chain Homo sapiens 73-83 6404305-1 1983 Three different gamma chains have been identified in fibrinogen isolated from normal human plasma with apparent molecular weights of 50000 (gamma 50), 55000 (gamma 55) and 57500 (gamma 57.5), as shown by SDS-polyacrylamide gel electrophoresis. Sodium Dodecyl Sulfate 204-207 fibrinogen beta chain Homo sapiens 53-63 6404305-1 1983 Three different gamma chains have been identified in fibrinogen isolated from normal human plasma with apparent molecular weights of 50000 (gamma 50), 55000 (gamma 55) and 57500 (gamma 57.5), as shown by SDS-polyacrylamide gel electrophoresis. polyacrylamide 208-222 fibrinogen beta chain Homo sapiens 53-63 6860649-0 1983 Dimeric half-molecules of human fibrinogen are joined through disulfide bonds in an antiparallel orientation. Disulfides 62-71 fibrinogen beta chain Homo sapiens 32-42 6868007-0 1983 Isolation o human fibrinogen of high purity and in high yield using polyethylene glycol 1000. polyethylene glycol 1000 68-92 fibrinogen beta chain Homo sapiens 18-28 6868007-1 1983 Fibrinogen was isolated from human plasma using a polyethylene glycol 1000 fractionation procedure that eliminates problems of denaturation, degradation and contamination encountered with other procedures (1). Polyethylene Glycols 50-69 fibrinogen beta chain Homo sapiens 0-10 6132131-1 1983 18 patients with severe hypertriglyceridaemia (mean fasting plasma triglyceride 5.7 mmol/l) had significantly higher concentrations of plasma fibrinogen and clotting factor Xc than did a normolipidaemic comparison group. Triglycerides 67-79 fibrinogen beta chain Homo sapiens 142-152 6219709-0 1983 The role of the lysine binding sites of human plasmin in the hydrolysis of human fibrinogen. Lysine 16-22 fibrinogen beta chain Homo sapiens 81-91 6219709-1 1983 The importance of the lysine binding sites of human plasmin for its ability to digest human fibrinogen has been assessed by analyzing the nature and rate of the products formed in the presence of epsilon-aminocaproic acid. Lysine 22-28 fibrinogen beta chain Homo sapiens 92-102 6219709-1 1983 The importance of the lysine binding sites of human plasmin for its ability to digest human fibrinogen has been assessed by analyzing the nature and rate of the products formed in the presence of epsilon-aminocaproic acid. Aminocaproic Acid 196-221 fibrinogen beta chain Homo sapiens 92-102 6219709-3 1983 The presence of epsilon-aminocaproic acid, at concentrations ranging from 0.5-5.0 mM, results in progressively stronger inhibition of the digestion of fibrinogen and in appearance of fibrinogen degradation products Y, D and E, for both Lys77-plasmin, and Val442-plasmin, showing the importance of lysine binding regions in this property. Aminocaproic Acid 16-41 fibrinogen beta chain Homo sapiens 151-161 6219709-3 1983 The presence of epsilon-aminocaproic acid, at concentrations ranging from 0.5-5.0 mM, results in progressively stronger inhibition of the digestion of fibrinogen and in appearance of fibrinogen degradation products Y, D and E, for both Lys77-plasmin, and Val442-plasmin, showing the importance of lysine binding regions in this property. Aminocaproic Acid 16-41 fibrinogen beta chain Homo sapiens 183-193 6219709-3 1983 The presence of epsilon-aminocaproic acid, at concentrations ranging from 0.5-5.0 mM, results in progressively stronger inhibition of the digestion of fibrinogen and in appearance of fibrinogen degradation products Y, D and E, for both Lys77-plasmin, and Val442-plasmin, showing the importance of lysine binding regions in this property. Lysine 297-303 fibrinogen beta chain Homo sapiens 183-193 6830792-2 1983 The degree of fluorescence anisotropy of diphenylhexatriene, anilinonaphthalene sulfonate (ANS) and fluorescamine increased significantly when fibrinogen reacted with its membrane receptors. Diphenylhexatriene 41-59 fibrinogen beta chain Homo sapiens 143-153 6830792-2 1983 The degree of fluorescence anisotropy of diphenylhexatriene, anilinonaphthalene sulfonate (ANS) and fluorescamine increased significantly when fibrinogen reacted with its membrane receptors. Anilino Naphthalenesulfonates 61-89 fibrinogen beta chain Homo sapiens 143-153 6830792-2 1983 The degree of fluorescence anisotropy of diphenylhexatriene, anilinonaphthalene sulfonate (ANS) and fluorescamine increased significantly when fibrinogen reacted with its membrane receptors. Anilino Naphthalenesulfonates 91-94 fibrinogen beta chain Homo sapiens 143-153 6830792-2 1983 The degree of fluorescence anisotropy of diphenylhexatriene, anilinonaphthalene sulfonate (ANS) and fluorescamine increased significantly when fibrinogen reacted with its membrane receptors. Fluorescamine 100-113 fibrinogen beta chain Homo sapiens 143-153 6222507-7 1983 Aggregation and secretion were enhanced by fibrinogen (optimal concentration 0.3-0.7 g.1(-1)), required Ca2+ or Mg2+ but were inhibited when Mg2+ or Ca2+ were present at a concentration of 2 mM or more. magnesium ion 112-116 fibrinogen beta chain Homo sapiens 43-53 6302680-4 1983 A2A9 was also a competitive inhibitor of fibrinogen binding to ADP-stimulated platelets. Adenosine Diphosphate 63-66 fibrinogen beta chain Homo sapiens 41-51 6302680-9 1983 In order to identify the platelet fibrinogen receptor, A2A9 immobilized on agarose was used for affinity chromatography. Sepharose 75-82 fibrinogen beta chain Homo sapiens 34-44 6654191-6 1983 A significant decrease in the AT-III level (p less than 0.01) and a significant increase (p less than 0.01) in the fibrinogen level were observed after heparin-dipyridamole treatment of patients suspected of IUGR. Heparin 152-159 fibrinogen beta chain Homo sapiens 115-125 6654191-6 1983 A significant decrease in the AT-III level (p less than 0.01) and a significant increase (p less than 0.01) in the fibrinogen level were observed after heparin-dipyridamole treatment of patients suspected of IUGR. Dipyridamole 160-172 fibrinogen beta chain Homo sapiens 115-125 6881359-7 1983 The rate of rouleaux formation in autologous plasma increased by (1) lowering the shear rates (1.9 less than or equal to gamma less than or equal to 15 s-1),2) increasing the hematocrit (up to 0.6%), 3) adding human fibrinogen (up to 600 mg/dl) or gamma-globulin, and 4) increasing pH. rouleaux 12-20 fibrinogen beta chain Homo sapiens 216-226 6857599-0 1983 Influence of fibrinogen fragments on human lymphocyte thymidine uptake. Thymidine 54-63 fibrinogen beta chain Homo sapiens 13-23 6403626-6 1983 111In associated with fibrinogen, IgM, and haptoglobin was over-estimated in some experiments due to binding of 111In-labeled C3 to the antigen-antibody precipitates. Indium-111 0-5 fibrinogen beta chain Homo sapiens 22-32 6827176-0 1983 Binding of fibrinogen to ADP-treated platelets. Adenosine Diphosphate 25-28 fibrinogen beta chain Homo sapiens 11-21 6827176-4 1983 We found that fibrinogen derivatives, isolated from plasma or obtained after limited plasmin digestion, that lacked approximately 13,000 to 46,000 MW peptides from the carboxyterminal of their A alpha chains (I-6, I-9, I-9D88) displayed undiminished capacity to support ADP-induced platelet aggregation and to bind to gel-filtered platelets. Adenosine Diphosphate 270-273 fibrinogen beta chain Homo sapiens 14-24 6827176-11 1983 Its binding to ADP-treated platelets was quantitatively similar to that of intact fibrinogen but its Scatchard plot was linear, with loss of low-affinity binding. Adenosine Diphosphate 15-18 fibrinogen beta chain Homo sapiens 82-92 6865038-0 1983 [Determination of fibrinogen subfractions by glycine method and SDS disc electrophoresis]. Glycine 45-52 fibrinogen beta chain Homo sapiens 18-28 6681716-2 1983 However, when fibrin and fibrinogen are digested with cyanogen bromide, both digests potentiate the t-PA-mediated plasminogen activation equally well. Cyanogen Bromide 54-70 fibrinogen beta chain Homo sapiens 25-35 6845271-4 1983 Using opacity ratio, syneresis, permeation and electron microscopy it was found that subcellular platelet material extracted into NaCl is able to influence fibrin network structure of clots made from purified fibrinogen as well as platelet-poor plasma. Sodium Chloride 130-134 fibrinogen beta chain Homo sapiens 209-219 6845272-1 1983 Heterogeneity in human fibrinogen was examined using an improved two-dimensional isoelectric focusing-SDS polyacrylamide gel electrophoretic procedure. Sodium Dodecyl Sulfate 102-105 fibrinogen beta chain Homo sapiens 23-33 6845272-1 1983 Heterogeneity in human fibrinogen was examined using an improved two-dimensional isoelectric focusing-SDS polyacrylamide gel electrophoretic procedure. polyacrylamide 106-120 fibrinogen beta chain Homo sapiens 23-33 6642541-0 1983 Solubility of buffalo fibrinogen in concentrated ammonium sulphate solution. Ammonium Sulfate 49-66 fibrinogen beta chain Homo sapiens 22-32 6189236-2 1983 Unfractionated heparin increased the binding of fibrinogen on ADP-treated platelets. Heparin 15-22 fibrinogen beta chain Homo sapiens 48-58 6189236-2 1983 Unfractionated heparin increased the binding of fibrinogen on ADP-treated platelets. Adenosine Diphosphate 62-65 fibrinogen beta chain Homo sapiens 48-58 6189236-6 1983 On the contrary, pentosane polysulfate, a sulfated polysaccharide (of low molecular weight) significantly increased the binding of fibrinogen (p less than 0.01). Pentosan Sulfuric Polyester 17-38 fibrinogen beta chain Homo sapiens 131-141 6189236-6 1983 On the contrary, pentosane polysulfate, a sulfated polysaccharide (of low molecular weight) significantly increased the binding of fibrinogen (p less than 0.01). Polysaccharides 51-65 fibrinogen beta chain Homo sapiens 131-141 6824684-7 1983 In citrate-containing plasma, the fibrinogen clotting was significantly delayed by an equimolar concentration of fragment D. In barium sulfate-adsorbed oxalated plasma, containing 2.5 mM Ca2+, the same amount of fragment D hardly affected fibrin polymerization. Citric Acid 3-10 fibrinogen beta chain Homo sapiens 34-44 6824684-7 1983 In citrate-containing plasma, the fibrinogen clotting was significantly delayed by an equimolar concentration of fragment D. In barium sulfate-adsorbed oxalated plasma, containing 2.5 mM Ca2+, the same amount of fragment D hardly affected fibrin polymerization. Barium Sulfate 128-142 fibrinogen beta chain Homo sapiens 34-44 6838953-6 1983 It was found that immobilized heparin forms complexes with fibrinogen, thrombin and plasmin that produce lytic action on unstabilized fibrin. Heparin 30-37 fibrinogen beta chain Homo sapiens 59-69 6216929-0 1983 Exposure of platelet fibrinogen-binding sites by collagen, arachidonic acid, and ADP: inhibition by a monoclonal antibody to the glycoprotein IIb-IIIa complex. Arachidonic Acid 59-75 fibrinogen beta chain Homo sapiens 21-31 6216929-0 1983 Exposure of platelet fibrinogen-binding sites by collagen, arachidonic acid, and ADP: inhibition by a monoclonal antibody to the glycoprotein IIb-IIIa complex. Adenosine Diphosphate 81-84 fibrinogen beta chain Homo sapiens 21-31 6216929-1 1983 Following stimulation with adenosine diphosphate (ADP), collagen, or arachidonic acid, unstirred human platelet suspensions bind 125I-fibrinogen in a reaction that reaches completion within 30 min. Adenosine Diphosphate 27-48 fibrinogen beta chain Homo sapiens 134-144 6216929-1 1983 Following stimulation with adenosine diphosphate (ADP), collagen, or arachidonic acid, unstirred human platelet suspensions bind 125I-fibrinogen in a reaction that reaches completion within 30 min. Adenosine Diphosphate 50-53 fibrinogen beta chain Homo sapiens 134-144 6216929-1 1983 Following stimulation with adenosine diphosphate (ADP), collagen, or arachidonic acid, unstirred human platelet suspensions bind 125I-fibrinogen in a reaction that reaches completion within 30 min. Arachidonic Acid 69-85 fibrinogen beta chain Homo sapiens 134-144 6216929-3 1983 At a concentration of apyrase that inhibited ADP-induced fibrinogen binding by greater than 85%, fibrinogen binding induced by collagen and arachidonic acid was only partially affected. Adenosine Diphosphate 45-48 fibrinogen beta chain Homo sapiens 57-67 6216929-3 1983 At a concentration of apyrase that inhibited ADP-induced fibrinogen binding by greater than 85%, fibrinogen binding induced by collagen and arachidonic acid was only partially affected. Arachidonic Acid 140-156 fibrinogen beta chain Homo sapiens 97-107 6216929-4 1983 This suggests that fibrinogen binding induced by collagen or arachidonic acid does not require released ADP. Arachidonic Acid 61-77 fibrinogen beta chain Homo sapiens 19-29 6216929-10 1983 These data demonstrate that collagen and arachidonic acid can expose fibrinogen binding sites independently of released ADP; and that the glycoprotein IIb-IIIa complex is involved in secretion, aggregation, and fibrinogen binding, but not in thromboxane synthesis occurring in response to collagen, arachidonic acid, or ADP. Arachidonic Acid 41-57 fibrinogen beta chain Homo sapiens 69-79 6851436-5 1983 Fibrinogen levels were found to be significantly higher in male smokers than male non-smokers, and in women were inversely correlated with alcohol consumption; despite this the ESR did not differ in smokers and non-smokers, nor was it related to alcohol intake. Alcohols 139-146 fibrinogen beta chain Homo sapiens 0-10 6851436-5 1983 Fibrinogen levels were found to be significantly higher in male smokers than male non-smokers, and in women were inversely correlated with alcohol consumption; despite this the ESR did not differ in smokers and non-smokers, nor was it related to alcohol intake. Alcohols 246-253 fibrinogen beta chain Homo sapiens 0-10 6222507-7 1983 Aggregation and secretion were enhanced by fibrinogen (optimal concentration 0.3-0.7 g.1(-1)), required Ca2+ or Mg2+ but were inhibited when Mg2+ or Ca2+ were present at a concentration of 2 mM or more. magnesium ion 141-145 fibrinogen beta chain Homo sapiens 43-53 6646049-1 1983 Binding of 125I-labelled fibrinogen from humans, bovines, equines, canines and ovines by streptococci of serological groups A, B, C and G was determined quantitatively. Iodine-125 11-15 fibrinogen beta chain Homo sapiens 25-35 6310117-2 1983 The degree of fluorescent anisotropy of DPH, ANS and fluorescamine increased significantly when fibrinogen reacted with its membrane receptors. Phenytoin 40-43 fibrinogen beta chain Homo sapiens 96-106 6310117-2 1983 The degree of fluorescent anisotropy of DPH, ANS and fluorescamine increased significantly when fibrinogen reacted with its membrane receptors. 1-anilino-8-naphthalenesulfonate 45-48 fibrinogen beta chain Homo sapiens 96-106 6310117-2 1983 The degree of fluorescent anisotropy of DPH, ANS and fluorescamine increased significantly when fibrinogen reacted with its membrane receptors. Fluorescamine 53-66 fibrinogen beta chain Homo sapiens 96-106 6310117-9 1983 In contrast to fibrinogen, calcium ions caused an increase of the fluorescence intensity resulting from the more efficient binding of ANS to the platelet membranes. 1-anilino-8-naphthalenesulfonate 134-137 fibrinogen beta chain Homo sapiens 15-25 6673224-6 1983 Freezing front measurements with albumin (BSA or HSA), immunoglobulin G (IgG), and fibrinogen adsorbed onto one and the same substrate material, octyl-sepharose beads, indicate that the hydrophobicity of the protein coated sepharose increased in the following order: BSA less than HSA less than IgG less than Fibrinogen. octyl-sepharose CL-4B 145-160 fibrinogen beta chain Homo sapiens 83-93 6579719-9 1983 The presence of fibrinogen is essential for platelet aggregation induced by adenosine diphosphate and for the observed changes in platelet surface charge. Adenosine Diphosphate 76-97 fibrinogen beta chain Homo sapiens 16-26 6223426-1 1983 A high-sensitive method is developed for determining the degree of plasmin-catalyzed fibrinogen hydrolysis by the released amino groups stained with trinitrobenzene sulphoacid. trinitrobenzene sulphoacid 149-175 fibrinogen beta chain Homo sapiens 85-95 6197788-2 1983 In both conditions blood viscosity, plasma viscosity, and plasma fibrinogen levels were significantly higher in those patients with capillary non-perfusion and/or new vessels on fluorescein angiography, compared to those patients without these complications. Fluorescein 178-189 fibrinogen beta chain Homo sapiens 65-75 7150660-0 1982 Human fibrinogen gel formed by the action of a cell surface polysaccharide obtained from a Staphylococcus. Polysaccharides 60-74 fibrinogen beta chain Homo sapiens 6-16 6294072-0 1982 Evidence that changes in platelet cyclic AMP levels regulate the fibrinogen receptor on human platelets. Cyclic AMP 34-44 fibrinogen beta chain Homo sapiens 65-75 6294072-2 1982 Since prostaglandin I2 (PGI2), a potent activator of platelet adenylate cyclase, prevents mobilization of the fibrinogen receptor by aggregating agents, we investigated the relationship between platelet cAMP levels and fibrinogen receptor status in thrombin-stimulated human platelets. Epoprostenol 6-22 fibrinogen beta chain Homo sapiens 110-120 6294072-2 1982 Since prostaglandin I2 (PGI2), a potent activator of platelet adenylate cyclase, prevents mobilization of the fibrinogen receptor by aggregating agents, we investigated the relationship between platelet cAMP levels and fibrinogen receptor status in thrombin-stimulated human platelets. Epoprostenol 24-28 fibrinogen beta chain Homo sapiens 110-120 6294072-3 1982 A dose-dependent rise in platelet cAMP in response to two adenylate cyclase agonists, PGI2 and forskolin, correlated with progressive inhibition of fibrinogen binding. Cyclic AMP 34-38 fibrinogen beta chain Homo sapiens 148-158 6294072-3 1982 A dose-dependent rise in platelet cAMP in response to two adenylate cyclase agonists, PGI2 and forskolin, correlated with progressive inhibition of fibrinogen binding. Epoprostenol 86-90 fibrinogen beta chain Homo sapiens 148-158 6294072-3 1982 A dose-dependent rise in platelet cAMP in response to two adenylate cyclase agonists, PGI2 and forskolin, correlated with progressive inhibition of fibrinogen binding. Colforsin 95-104 fibrinogen beta chain Homo sapiens 148-158 6294072-5 1982 The phosphodiesterase inhibitor, 1-methyl-3-isobutylxanthine, in the presence of a subthreshold concentration of PGI2 also raised cAMP and inhibited fibrinogen binding. 1-Methyl-3-isobutylxanthine 33-60 fibrinogen beta chain Homo sapiens 149-159 6294072-5 1982 The phosphodiesterase inhibitor, 1-methyl-3-isobutylxanthine, in the presence of a subthreshold concentration of PGI2 also raised cAMP and inhibited fibrinogen binding. Epoprostenol 113-117 fibrinogen beta chain Homo sapiens 149-159 6294072-6 1982 In contrast, the effects of PGI2 on both cAMP and fibrinogen binding were markedly attenuated by 9-(tetrahydro-2-furyl) adenine, an adenylate cyclase inhibitor. Epoprostenol 28-32 fibrinogen beta chain Homo sapiens 50-60 6294072-6 1982 In contrast, the effects of PGI2 on both cAMP and fibrinogen binding were markedly attenuated by 9-(tetrahydro-2-furyl) adenine, an adenylate cyclase inhibitor. 9-(tetrahydro-2-furyl)-adenine 97-127 fibrinogen beta chain Homo sapiens 50-60 6294072-7 1982 These results indicate that the inhibition of fibrinogen binding by PgI2 is linked to its effect on cAMP levels and suggest that elevation of platelet cAMP levels from any cause prevents exposure of the fibrinogen receptor. Epoprostenol 68-72 fibrinogen beta chain Homo sapiens 46-56 6294072-7 1982 These results indicate that the inhibition of fibrinogen binding by PgI2 is linked to its effect on cAMP levels and suggest that elevation of platelet cAMP levels from any cause prevents exposure of the fibrinogen receptor. Epoprostenol 68-72 fibrinogen beta chain Homo sapiens 203-213 6294072-7 1982 These results indicate that the inhibition of fibrinogen binding by PgI2 is linked to its effect on cAMP levels and suggest that elevation of platelet cAMP levels from any cause prevents exposure of the fibrinogen receptor. Cyclic AMP 100-104 fibrinogen beta chain Homo sapiens 46-56 6294072-7 1982 These results indicate that the inhibition of fibrinogen binding by PgI2 is linked to its effect on cAMP levels and suggest that elevation of platelet cAMP levels from any cause prevents exposure of the fibrinogen receptor. Cyclic AMP 151-155 fibrinogen beta chain Homo sapiens 46-56 6294072-7 1982 These results indicate that the inhibition of fibrinogen binding by PgI2 is linked to its effect on cAMP levels and suggest that elevation of platelet cAMP levels from any cause prevents exposure of the fibrinogen receptor. Cyclic AMP 151-155 fibrinogen beta chain Homo sapiens 203-213 7131084-0 1982 Technetium-99m labeling of antibodies to cardiac myosin Fab and to human fibrinogen. Technetium-99 0-13 fibrinogen beta chain Homo sapiens 73-83 7131084-1 1982 We have developed a method of labeling biologically active labile macromolecules, such as human fibrinogen (HF) and anticardiac-myosin Fab (AM-Fab), with Tc-99m at neutral pH. tc-99 154-159 fibrinogen beta chain Homo sapiens 96-106 7131084-3 1982 Complexes of diethylene triamine pentaacetic acid with macromolecules such as human fibrinogen (D-HF) and anticardiac-myosin Fab (D-AM-Fab) were labeled and utilized in in vitro and in vivo studies. Pentetic Acid 13-49 fibrinogen beta chain Homo sapiens 84-94 7150549-8 1982 182, 227] has demonstrated the importance of Phe-Leu at positions P9-P8 of the A alpha chain of fibrinogen for the thrombin-fibrinogen interaction. Phenylalanine 45-48 fibrinogen beta chain Homo sapiens 96-106 7150549-8 1982 182, 227] has demonstrated the importance of Phe-Leu at positions P9-P8 of the A alpha chain of fibrinogen for the thrombin-fibrinogen interaction. Phenylalanine 45-48 fibrinogen beta chain Homo sapiens 124-134 7150549-8 1982 182, 227] has demonstrated the importance of Phe-Leu at positions P9-P8 of the A alpha chain of fibrinogen for the thrombin-fibrinogen interaction. Leucine 49-52 fibrinogen beta chain Homo sapiens 96-106 7150549-8 1982 182, 227] has demonstrated the importance of Phe-Leu at positions P9-P8 of the A alpha chain of fibrinogen for the thrombin-fibrinogen interaction. Leucine 49-52 fibrinogen beta chain Homo sapiens 124-134 7150549-9 1982 This work demonstrates that the presence of Leu (P8) alone is insufficient to account for the enhanced hydrolysis rates and that the presence of Phe (P9) is essential for normal action of thrombin on the A alpha chain of fibrinogen. Phenylalanine 145-148 fibrinogen beta chain Homo sapiens 221-231 6182968-5 1982 Intravenous administration of dextran, although effective, was expensive, and leg scanning with iodine-125-labelled fibrinogen was extremely expensive. Iodine-125 96-106 fibrinogen beta chain Homo sapiens 116-126 6216917-0 1982 Anticoagulant and calcium-binding properties of high molecular weight derivatives of human fibrinogen (plasmin fragments Y). Calcium 18-25 fibrinogen beta chain Homo sapiens 91-101 6216917-1 1982 The present study was undertaken as a step to delineate further the localization of the calcium-binding sites in fibrinogen and to assess the anticlotting properties of fibrinogen degradation products. Calcium 88-95 fibrinogen beta chain Homo sapiens 113-123 7126865-6 1982 Fibrinogen in high concentrations affects the assay, probably by interfering with the interactions of 125I-a with antibody. 125i-a 102-108 fibrinogen beta chain Homo sapiens 0-10 6812617-0 1982 Polyvinylpyrrolidone as a precipitating agent for active VIII and fibrinogen. Povidone 0-20 fibrinogen beta chain Homo sapiens 66-76 6754619-7 1982 Adherence of 3H-labeled streptococci to fibrinogen-treated, virus-infected cell cultures showed saturation kinetics and could be blocked with monospecific antibodies against fibrinogen. Tritium 13-15 fibrinogen beta chain Homo sapiens 40-50 6754619-7 1982 Adherence of 3H-labeled streptococci to fibrinogen-treated, virus-infected cell cultures showed saturation kinetics and could be blocked with monospecific antibodies against fibrinogen. Tritium 13-15 fibrinogen beta chain Homo sapiens 174-184 6294903-1 1982 Human fibrinogen was labeled with 99m-Technetium. Technetium 34-48 fibrinogen beta chain Homo sapiens 6-16 6294903-3 1982 Before adding the fibrinogen, the citric acid was always neutralized with sodium hydrogen carbonate. Citric Acid 34-45 fibrinogen beta chain Homo sapiens 18-28 6294903-3 1982 Before adding the fibrinogen, the citric acid was always neutralized with sodium hydrogen carbonate. Sodium Bicarbonate 74-99 fibrinogen beta chain Homo sapiens 18-28 7150660-1 1982 An alkali-stable polysaccharide (called compact-colony forming active substance; substance 1) obtained from the cell surface of a strain of Staphylococcus epidermidis caused gel formation of human fibrinogen, with no release of fibrinopeptides. Polysaccharides 17-31 fibrinogen beta chain Homo sapiens 197-207 6294903-4 1982 The influences on the quantity of fibrinogen bound 99m-Tc of the relative concentrations of Sn(II), fibrinogen and sodium hydrogen carbonate, of the reaction time and temperature were tested by thin-layer chromatography. sn(ii) 92-98 fibrinogen beta chain Homo sapiens 34-44 6294903-4 1982 The influences on the quantity of fibrinogen bound 99m-Tc of the relative concentrations of Sn(II), fibrinogen and sodium hydrogen carbonate, of the reaction time and temperature were tested by thin-layer chromatography. Sodium Bicarbonate 115-140 fibrinogen beta chain Homo sapiens 34-44 6294903-5 1982 The reaction temperature of 28 degrees C showed an optimum of fibrinogen bound 99m-Tc for the reaction time from 1 and 2 hours. Technetium 79-85 fibrinogen beta chain Homo sapiens 62-72 7150660-3 1982 Heparin and galactose prevented gel formation of fibrinogen with substance 1. Heparin 0-7 fibrinogen beta chain Homo sapiens 49-59 6294903-8 1982 At values higher than 34 times of the fibrinogen concentration a decrease of the quantity of bound 99m-Tc was observed. Technetium 99-105 fibrinogen beta chain Homo sapiens 38-48 7150660-3 1982 Heparin and galactose prevented gel formation of fibrinogen with substance 1. Galactose 12-21 fibrinogen beta chain Homo sapiens 49-59 6294903-9 1982 The concentrations of sodium hydrogen carbonate showed no influence on the quantity of fibrinogen bound 99m-Tc but on the clottability of fibrinogen, the pH of the solution must be approximately 7.5. Sodium Bicarbonate 22-47 fibrinogen beta chain Homo sapiens 138-148 6294903-11 1982 Controls of these results by column chromatography showed a binding of 81.08 +/- 1.47 % of 99m-Tc to fibrinogen. Technetium 91-97 fibrinogen beta chain Homo sapiens 101-111 6129716-1 1982 The trimethyl oxonium ion specifically modified the free carboxyl groups of fibrinogen. trimethyloxonium 4-21 fibrinogen beta chain Homo sapiens 76-86 6288701-5 1982 Fibrinogen was digested with plasmin in the presence of 5 mM calcium and fragment D and E of Mr 100,000 and 50,000, respectively, were isolated. Calcium 61-68 fibrinogen beta chain Homo sapiens 0-10 6129716-3 1982 The extent of methylation of fibrinogen was evaluated by methoxyl determination at each step of the polymerization process. 7-methoxy-6-(2'-methoxy-3'-hydroxy-3'-methyl butyl) 57-65 fibrinogen beta chain Homo sapiens 29-39 6129716-6 1982 The sites of methylation were ascertained by chromatographic analysis which resulted in the identification of beta-methyl aspartic acid and gamma-methyl glutamic acid derivatives of the fibrinogen. beta-methyl aspartic acid 110-135 fibrinogen beta chain Homo sapiens 186-196 6129716-6 1982 The sites of methylation were ascertained by chromatographic analysis which resulted in the identification of beta-methyl aspartic acid and gamma-methyl glutamic acid derivatives of the fibrinogen. gamma-methyl glutamic acid 140-166 fibrinogen beta chain Homo sapiens 186-196 6129716-8 1982 Based on this experimental data, it was formulated that the methylation of fibrinogen involved the esterification of the carboxyl groups of aspartic and glutamic acid with the resultant reduction of negative repulsion between the fibrinogen molecules and thereby culminated in the polymerization of the modified fibrinogen. aspartic 140-148 fibrinogen beta chain Homo sapiens 75-85 6129716-8 1982 Based on this experimental data, it was formulated that the methylation of fibrinogen involved the esterification of the carboxyl groups of aspartic and glutamic acid with the resultant reduction of negative repulsion between the fibrinogen molecules and thereby culminated in the polymerization of the modified fibrinogen. aspartic 140-148 fibrinogen beta chain Homo sapiens 230-240 6129716-8 1982 Based on this experimental data, it was formulated that the methylation of fibrinogen involved the esterification of the carboxyl groups of aspartic and glutamic acid with the resultant reduction of negative repulsion between the fibrinogen molecules and thereby culminated in the polymerization of the modified fibrinogen. aspartic 140-148 fibrinogen beta chain Homo sapiens 230-240 6129716-8 1982 Based on this experimental data, it was formulated that the methylation of fibrinogen involved the esterification of the carboxyl groups of aspartic and glutamic acid with the resultant reduction of negative repulsion between the fibrinogen molecules and thereby culminated in the polymerization of the modified fibrinogen. Glutamic Acid 153-166 fibrinogen beta chain Homo sapiens 75-85 6129716-8 1982 Based on this experimental data, it was formulated that the methylation of fibrinogen involved the esterification of the carboxyl groups of aspartic and glutamic acid with the resultant reduction of negative repulsion between the fibrinogen molecules and thereby culminated in the polymerization of the modified fibrinogen. Glutamic Acid 153-166 fibrinogen beta chain Homo sapiens 230-240 6129716-8 1982 Based on this experimental data, it was formulated that the methylation of fibrinogen involved the esterification of the carboxyl groups of aspartic and glutamic acid with the resultant reduction of negative repulsion between the fibrinogen molecules and thereby culminated in the polymerization of the modified fibrinogen. Glutamic Acid 153-166 fibrinogen beta chain Homo sapiens 230-240 7138883-0 1982 A fibrinogen fragment D (D intermediate) with calcium binding but without anticlotting properties. Calcium 46-53 fibrinogen beta chain Homo sapiens 2-12 6288146-1 1982 Previous analysis of fibrinogen binding to human aspirin-treated gel-filtered platelets yielded upwardly concave Scatchard plots. Aspirin 49-56 fibrinogen beta chain Homo sapiens 21-31 7138883-1 1982 Plasmin digestion of fibrinogen in the presence of Ca2+ or of EGTA leads to the formation of two sets of fragments, designated Dcate and D EGTA, respectively. Egtazic Acid 62-66 fibrinogen beta chain Homo sapiens 21-31 7138883-1 1982 Plasmin digestion of fibrinogen in the presence of Ca2+ or of EGTA leads to the formation of two sets of fragments, designated Dcate and D EGTA, respectively. dcate 127-132 fibrinogen beta chain Homo sapiens 21-31 7138883-1 1982 Plasmin digestion of fibrinogen in the presence of Ca2+ or of EGTA leads to the formation of two sets of fragments, designated Dcate and D EGTA, respectively. Egtazic Acid 139-143 fibrinogen beta chain Homo sapiens 21-31 6890955-5 1982 SK-potentiator showed a similar mobility to that of fibrinogen on both SDS-polyacrylamide gel and agarose gel electrophoresis, and cross-reacted with anti-fibrinogen antiserum. Sodium Dodecyl Sulfate 71-74 fibrinogen beta chain Homo sapiens 52-62 6890955-5 1982 SK-potentiator showed a similar mobility to that of fibrinogen on both SDS-polyacrylamide gel and agarose gel electrophoresis, and cross-reacted with anti-fibrinogen antiserum. polyacrylamide 75-89 fibrinogen beta chain Homo sapiens 52-62 6890955-8 1982 In the presence of 2-mercaptoethanol, it showed two major bands with molecular weights of 53,000 and 48,000, respectively, which corresponded to the B beta chain and gamma chain of fibrinogen. Mercaptoethanol 19-36 fibrinogen beta chain Homo sapiens 181-191 6890955-5 1982 SK-potentiator showed a similar mobility to that of fibrinogen on both SDS-polyacrylamide gel and agarose gel electrophoresis, and cross-reacted with anti-fibrinogen antiserum. Sepharose 98-105 fibrinogen beta chain Homo sapiens 52-62 7157227-0 1982 Altered mobility of fibrinogen gamma chains and gamma dimer in discontinuous SDS-polyacrylamide electrophoresis. Sodium Dodecyl Sulfate 77-80 fibrinogen beta chain Homo sapiens 20-30 6959118-6 1982 Fibrinogen also was found to increase the plating efficiency and colony size when human bone marrow cells were cultured in semisolid medium containing serum. semisolid medium 123-139 fibrinogen beta chain Homo sapiens 0-10 7157227-0 1982 Altered mobility of fibrinogen gamma chains and gamma dimer in discontinuous SDS-polyacrylamide electrophoresis. polyacrylamide 81-95 fibrinogen beta chain Homo sapiens 20-30 7135341-0 1982 The intrinsic fluorescence of human fibrinogen and its fragments D and E. The tryptophan fluorescence of fibrinogen and its final degradation products--fragment D and E--were compared. Tryptophan 78-88 fibrinogen beta chain Homo sapiens 105-115 6217586-7 1982 The presence of Ala, in addition to Gly and Tyr in the fibrin clot and its supernatant, showed that a part of fibrinogen molecules was not clotted, i.e. either copolymerised with fibrin or remaining in solutions. Alanine 16-19 fibrinogen beta chain Homo sapiens 110-120 6213638-2 1982 The formation of the fibrinogen-thrombospondin complex was specific, saturable, and partially inhibited by mannosamine, glucosamine, and arginine. mannosamine 107-118 fibrinogen beta chain Homo sapiens 21-31 6213638-2 1982 The formation of the fibrinogen-thrombospondin complex was specific, saturable, and partially inhibited by mannosamine, glucosamine, and arginine. Glucosamine 120-131 fibrinogen beta chain Homo sapiens 21-31 6213638-2 1982 The formation of the fibrinogen-thrombospondin complex was specific, saturable, and partially inhibited by mannosamine, glucosamine, and arginine. Arginine 137-145 fibrinogen beta chain Homo sapiens 21-31 7146823-5 1982 No significant changes of blood coagulation picture were observed after vitamin K administration, while calcium-heparin treatment showed an increase in prothrombin time, fibrinogen, platelet count, plasminogen, alpha 2-antiplasmin, a decrease in fibrin(ogen) degradation products and a shortened activated partial thromboplastin time. calcium heparin 104-119 fibrinogen beta chain Homo sapiens 170-180 7107587-0 1982 Carbohydrate structure of human fibrinogen. Carbohydrates 0-12 fibrinogen beta chain Homo sapiens 32-42 7135341-3 1982 Our studies showed that tryptophan residues of core fragments D and E are much more exposed to quenching effects of acrylamide and ions than intact fibrinogen, which may be caused by conformational changes occurring over the domains during plasmin digestion of fibrinogen molecule. Tryptophan 24-34 fibrinogen beta chain Homo sapiens 261-271 7107587-2 1982 The carbohydrate composition of fibrinogen and constituent S-carboxymethylated chains was determined. Carbohydrates 4-16 fibrinogen beta chain Homo sapiens 32-42 7135341-3 1982 Our studies showed that tryptophan residues of core fragments D and E are much more exposed to quenching effects of acrylamide and ions than intact fibrinogen, which may be caused by conformational changes occurring over the domains during plasmin digestion of fibrinogen molecule. Acrylamide 116-126 fibrinogen beta chain Homo sapiens 261-271 7107587-12 1982 Affinity chromatography of the glycopeptides on concanavalin A-Sepharose also showed that the glycopeptides from fibrinogen are greater than 95% biantennary oligosaccharide chains. Glycopeptides 31-44 fibrinogen beta chain Homo sapiens 113-123 7107587-12 1982 Affinity chromatography of the glycopeptides on concanavalin A-Sepharose also showed that the glycopeptides from fibrinogen are greater than 95% biantennary oligosaccharide chains. Sepharose 63-72 fibrinogen beta chain Homo sapiens 113-123 7147211-2 1982 The removal, with time, of sialic acid residues from human fibrinogen by neuraminidase, can be explained, as a result of a mathematical analysis, by the summation of two first order reactions with clearly different rate constants. N-Acetylneuraminic Acid 27-38 fibrinogen beta chain Homo sapiens 59-69 7107587-12 1982 Affinity chromatography of the glycopeptides on concanavalin A-Sepharose also showed that the glycopeptides from fibrinogen are greater than 95% biantennary oligosaccharide chains. Glycopeptides 94-107 fibrinogen beta chain Homo sapiens 113-123 7107587-12 1982 Affinity chromatography of the glycopeptides on concanavalin A-Sepharose also showed that the glycopeptides from fibrinogen are greater than 95% biantennary oligosaccharide chains. Oligosaccharides 157-172 fibrinogen beta chain Homo sapiens 113-123 7107587-13 1982 Based on carbohydrate composition, 1H-NMR spectroscopy, sequential exoglycosidase digestion, and gas chromatography-mass spectrometry of derived partially methylated alditol acetates, we propose that fibrinogen contains four oligosaccharide chains of the structure shown below. Carbohydrates 9-21 fibrinogen beta chain Homo sapiens 200-210 7107587-13 1982 Based on carbohydrate composition, 1H-NMR spectroscopy, sequential exoglycosidase digestion, and gas chromatography-mass spectrometry of derived partially methylated alditol acetates, we propose that fibrinogen contains four oligosaccharide chains of the structure shown below. alditol acetates 166-182 fibrinogen beta chain Homo sapiens 200-210 7107587-13 1982 Based on carbohydrate composition, 1H-NMR spectroscopy, sequential exoglycosidase digestion, and gas chromatography-mass spectrometry of derived partially methylated alditol acetates, we propose that fibrinogen contains four oligosaccharide chains of the structure shown below. Oligosaccharides 225-240 fibrinogen beta chain Homo sapiens 200-210 7147211-3 1982 Quantitative studies on the bound sialic acid to isolated fibrinogen chains, after reduction and alkylation of the partially desialylated fibrinogen, show that the fast reaction takes place with the sialic acid bound to the B beta chains. N-Acetylneuraminic Acid 34-45 fibrinogen beta chain Homo sapiens 58-68 7147211-3 1982 Quantitative studies on the bound sialic acid to isolated fibrinogen chains, after reduction and alkylation of the partially desialylated fibrinogen, show that the fast reaction takes place with the sialic acid bound to the B beta chains. N-Acetylneuraminic Acid 34-45 fibrinogen beta chain Homo sapiens 138-148 7147211-3 1982 Quantitative studies on the bound sialic acid to isolated fibrinogen chains, after reduction and alkylation of the partially desialylated fibrinogen, show that the fast reaction takes place with the sialic acid bound to the B beta chains. N-Acetylneuraminic Acid 199-210 fibrinogen beta chain Homo sapiens 58-68 6185106-3 1982 After initial contradictory results, the extrafraction was determined to be fibrinogen, present because of the slow release of heparin contained in the catheter, so that electrophoresis was performed on plasma instead of on serum. Heparin 127-134 fibrinogen beta chain Homo sapiens 76-86 6806381-0 1982 Identification of the physiologically active state of the mycobacterial glycolipid trehalose 6,6"-dimycolate and the role of fibrinogen in the biologic activities of trehalose 6,6"-dimycolate monolayers. Cord Factors 166-191 fibrinogen beta chain Homo sapiens 125-135 7135350-6 1982 Binding strength for immobilized heparin is decreased in the array fibrinogen congruent to thrombin much greater than plasmin greater than serum albumin. Heparin 33-40 fibrinogen beta chain Homo sapiens 67-77 7135350-7 1982 Complexes of immobilized heparin with fibrinogen, thrombin and plasmin display lytic action towards unstabilized fibrin. Heparin 25-32 fibrinogen beta chain Homo sapiens 38-48 6282365-0 1982 Induction of human platelet fibrinogen receptors by epinephrine in the absence of released ADP. Epinephrine 52-63 fibrinogen beta chain Homo sapiens 28-38 6282365-1 1982 The ability of epinephrine to expose platelet fibrinogen receptors independent of released ADP was assessed using aspirin-treated, gel-filtered platelets. Epinephrine 15-26 fibrinogen beta chain Homo sapiens 46-56 6282365-2 1982 Similar to ADP-induced aggregation, platelet aggregation in response to epinephrine was accompanied by fibrinogen binding. Epinephrine 72-83 fibrinogen beta chain Homo sapiens 103-113 6282365-3 1982 Ten micromolar epinephrine induced a maximum number of platelet fibrinogen receptors in the absence of significant 14C-serotonin release. Epinephrine 15-26 fibrinogen beta chain Homo sapiens 64-74 6282365-4 1982 As indicated by Scatchard analysis, receptors exposed by both epinephrine and ADP had similar affinities for fibrinogen, but epinephrine induced approximately 30% fewer receptors than did ADP. Adenosine Diphosphate 78-81 fibrinogen beta chain Homo sapiens 109-119 6282365-4 1982 As indicated by Scatchard analysis, receptors exposed by both epinephrine and ADP had similar affinities for fibrinogen, but epinephrine induced approximately 30% fewer receptors than did ADP. Epinephrine 62-73 fibrinogen beta chain Homo sapiens 109-119 6282365-6 1982 Studies using phentolamine, a specific alpha-adrenergic antagonist, apyrase, or creatine phosphate/creatine kinase indicate that the exposure of platelet fibrinogen receptors by epinephrine was specific for platelet alpha-adrenergic receptor stimulation and was not the result of released ADP. Phentolamine 14-26 fibrinogen beta chain Homo sapiens 154-164 6282365-6 1982 Studies using phentolamine, a specific alpha-adrenergic antagonist, apyrase, or creatine phosphate/creatine kinase indicate that the exposure of platelet fibrinogen receptors by epinephrine was specific for platelet alpha-adrenergic receptor stimulation and was not the result of released ADP. Epinephrine 178-189 fibrinogen beta chain Homo sapiens 154-164 6282365-6 1982 Studies using phentolamine, a specific alpha-adrenergic antagonist, apyrase, or creatine phosphate/creatine kinase indicate that the exposure of platelet fibrinogen receptors by epinephrine was specific for platelet alpha-adrenergic receptor stimulation and was not the result of released ADP. Adenosine Diphosphate 289-292 fibrinogen beta chain Homo sapiens 154-164 7173813-1 1982 Sodium dodecyl sulfate-polyacrylamide gel electrophoresis utilizing a large pore gel showed that human fibrinogen (Fbg) in plasma resolved into 3 components which were tentatively designated as high molecular weight Fbg (HMW), low molecular weight Fbg1 (LMW1) and low molecular weight Fbg2 (LMW2) in order of their electrophoretic mobilities. Sodium Dodecyl Sulfate 0-22 fibrinogen beta chain Homo sapiens 103-113 7173813-1 1982 Sodium dodecyl sulfate-polyacrylamide gel electrophoresis utilizing a large pore gel showed that human fibrinogen (Fbg) in plasma resolved into 3 components which were tentatively designated as high molecular weight Fbg (HMW), low molecular weight Fbg1 (LMW1) and low molecular weight Fbg2 (LMW2) in order of their electrophoretic mobilities. Sodium Dodecyl Sulfate 0-22 fibrinogen beta chain Homo sapiens 115-118 7173813-1 1982 Sodium dodecyl sulfate-polyacrylamide gel electrophoresis utilizing a large pore gel showed that human fibrinogen (Fbg) in plasma resolved into 3 components which were tentatively designated as high molecular weight Fbg (HMW), low molecular weight Fbg1 (LMW1) and low molecular weight Fbg2 (LMW2) in order of their electrophoretic mobilities. polyacrylamide 23-37 fibrinogen beta chain Homo sapiens 103-113 7086532-0 1982 Evaluation of the viability of In-111-labeled DTPA coupled to fibrinogen. Indium-111 31-37 fibrinogen beta chain Homo sapiens 62-72 6214865-0 1982 Fractionation of plasmic fibrinogen digest on lysine-agarose. Lysine 46-52 fibrinogen beta chain Homo sapiens 25-35 6214865-0 1982 Fractionation of plasmic fibrinogen digest on lysine-agarose. Sepharose 53-60 fibrinogen beta chain Homo sapiens 25-35 7076665-4 1982 125I-platelet and plasma Factor XIII specifically bound to human fibrinogen covalently coupled to either carboxylated latex or acrylonitrile beads but not to fetuin- or albumin-coated beads. Latex 118-123 fibrinogen beta chain Homo sapiens 65-75 7076665-4 1982 125I-platelet and plasma Factor XIII specifically bound to human fibrinogen covalently coupled to either carboxylated latex or acrylonitrile beads but not to fetuin- or albumin-coated beads. Acrylonitrile 127-140 fibrinogen beta chain Homo sapiens 65-75 7073911-10 1982 Fibrinogen measured by both methods had positive and statistically significant associations with serum total cholesterol, but no associations with serum total triglycerides, smoking, or alcohol consumption. Cholesterol 109-120 fibrinogen beta chain Homo sapiens 0-10 7093524-5 1982 This finding is thought to reflect heparin suppression of thrombin activity on fibrinogen. Heparin 35-42 fibrinogen beta chain Homo sapiens 79-89 6288458-0 1982 Phosphorylation of human fibrinogen in vitro with calcium-activated phospholipid-dependent protein kinase and [32P]ATP. Phosphorus-32 111-114 fibrinogen beta chain Homo sapiens 25-35 6288458-0 1982 Phosphorylation of human fibrinogen in vitro with calcium-activated phospholipid-dependent protein kinase and [32P]ATP. Adenosine Triphosphate 115-118 fibrinogen beta chain Homo sapiens 25-35 7118871-0 1982 Comparative studies on the structures of the carbohydrate moieties of human fibrinogen and abnormal fibrinogen Nagoya. Carbohydrates 45-57 fibrinogen beta chain Homo sapiens 76-86 7118871-0 1982 Comparative studies on the structures of the carbohydrate moieties of human fibrinogen and abnormal fibrinogen Nagoya. Carbohydrates 45-57 fibrinogen beta chain Homo sapiens 100-110 7118871-1 1982 Human fibrinogen contains four asparagine-linked sugar chains in one molecule. Asparagine 31-41 fibrinogen beta chain Homo sapiens 6-16 7118871-1 1982 Human fibrinogen contains four asparagine-linked sugar chains in one molecule. Sugars 49-54 fibrinogen beta chain Homo sapiens 6-16 6954514-0 1982 Inhibition of fibrinogen binding to human platelets by the tetrapeptide glycyl-L-prolyl-L-arginyl-L-proline. glycyl-l-prolyl-l-arginyl-l-proline 72-107 fibrinogen beta chain Homo sapiens 14-24 6954514-2 1982 In the present study, we demonstrate that the tetrapeptide glycyl-L-prolyl-L-arginyl-L-proline inhibits the interaction of fibrinogen with its platelet receptor. glycyl-l-prolyl-l-arginyl-l-proline 59-94 fibrinogen beta chain Homo sapiens 123-133 6954514-5 1982 The inhibition was dependent upon fibrinogen concentration and occurred in the presence of calcium or magnesium. Calcium 91-98 fibrinogen beta chain Homo sapiens 34-44 6954514-5 1982 The inhibition was dependent upon fibrinogen concentration and occurred in the presence of calcium or magnesium. Magnesium 102-111 fibrinogen beta chain Homo sapiens 34-44 6954514-8 1982 Fibrinogen-dependent aggregation of washed platelets by ADP was abolished by a 30-fold molar excess of the peptide. Adenosine Diphosphate 56-59 fibrinogen beta chain Homo sapiens 0-10 6954514-14 1982 A peptide corresponding to the natural sequence, glycyl-L-prolyl-L-arginyl-L-valyl-L-valine, was also capable of inhibiting fibrinogen binding to the platelet. glycyl-l-prolyl-l-arginyl-l-valyl-l-valine 49-91 fibrinogen beta chain Homo sapiens 124-134 7147211-3 1982 Quantitative studies on the bound sialic acid to isolated fibrinogen chains, after reduction and alkylation of the partially desialylated fibrinogen, show that the fast reaction takes place with the sialic acid bound to the B beta chains. N-Acetylneuraminic Acid 199-210 fibrinogen beta chain Homo sapiens 138-148 7147211-5 1982 Coagulation with thrombin of desialylated fibrinogen shows that the aggregation rate increases linearly as the amount of sialic acid residues decreases, regardless of their location in the fibrinogen molecule. N-Acetylneuraminic Acid 121-132 fibrinogen beta chain Homo sapiens 42-52 7066337-0 1982 Potential role of the A alpha chain in the binding of calcium to human fibrinogen. Calcium 54-61 fibrinogen beta chain Homo sapiens 71-81 6802165-0 1982 Polyvinylpyrrolidone (PVP): a new precipitating agent for human and bovine factor VIII and fibrinogen. Povidone 0-20 fibrinogen beta chain Homo sapiens 91-101 6802165-0 1982 Polyvinylpyrrolidone (PVP): a new precipitating agent for human and bovine factor VIII and fibrinogen. Povidone 22-25 fibrinogen beta chain Homo sapiens 91-101 7083646-8 1982 We found that heparin also decreased fibrinogen, hematocrit, serum alpha 2 globulin, and number of platelets. Heparin 14-21 fibrinogen beta chain Homo sapiens 37-47 6281794-6 1982 Monospecific antibody fragments against the gamma chain inhibited binding of 125I-labeled fibrinogen to the human platelet receptor and blocked aggregation of platelets induced by ADP in the presence of fibrinogen or gamma-chain multimers. Iodine-125 77-81 fibrinogen beta chain Homo sapiens 90-100 6281794-6 1982 Monospecific antibody fragments against the gamma chain inhibited binding of 125I-labeled fibrinogen to the human platelet receptor and blocked aggregation of platelets induced by ADP in the presence of fibrinogen or gamma-chain multimers. Adenosine Diphosphate 180-183 fibrinogen beta chain Homo sapiens 90-100 6281794-6 1982 Monospecific antibody fragments against the gamma chain inhibited binding of 125I-labeled fibrinogen to the human platelet receptor and blocked aggregation of platelets induced by ADP in the presence of fibrinogen or gamma-chain multimers. Adenosine Diphosphate 180-183 fibrinogen beta chain Homo sapiens 203-213 7071802-0 1982 Sialic acid dependent polypeptide chain heterogeneity of human fibrinogen demonstrated by two-dimensional electrophoresis. N-Acetylneuraminic Acid 0-11 fibrinogen beta chain Homo sapiens 63-73 7071802-6 1982 It is concluded that enzymatic removal of sialic acid partially reduced the heterogeneity of the gamma- and B beta-polypeptide chains of human fibrinogen, but additional sources producing charge heterogeneity must be sought. N-Acetylneuraminic Acid 42-53 fibrinogen beta chain Homo sapiens 143-153 7056710-0 1982 A subfraction of human fibrinogen with high sialic acid content and elongated gamma chains. N-Acetylneuraminic Acid 44-55 fibrinogen beta chain Homo sapiens 23-33 7056710-1 1982 Fibrinogen isolated from normal human single donor or pool plasma was fractionated by DEAE-cellulose chromatography. DEAE-Cellulose 86-100 fibrinogen beta chain Homo sapiens 0-10 7056710-3 1982 The most acidic fraction comprising 22% of the whole fibrinogen pool was prominent by two special features: 1) its sialic acid content was significantly higher than that of bulk fibrinogen, namely 8 mol of sialic acid/mol of fibrinogen versus 6 mol in bulk fibrinogen. N-Acetylneuraminic Acid 115-126 fibrinogen beta chain Homo sapiens 53-63 7064136-6 1982 Ethanol precipitation allows for fibrinogen removal and a near quantitative recovery of both added B beta 15-42 peptide as well as of the endogenous blood peptide(s) containing the B beta 15-42 sequence. Ethanol 0-7 fibrinogen beta chain Homo sapiens 33-43 6895702-7 1982 The clotting activity of thrombin on fibrinogen was partially inhibited by the amines while its esterolytic activity remained unaltered. Amines 79-85 fibrinogen beta chain Homo sapiens 37-47 6460044-3 1982 The formation of this GPIIb-GPIIIa fibrinogen complex is calcium dependent, fibrinogen specific, saturable, and inhibited by specific amino sugars and amino acids. Calcium 57-64 fibrinogen beta chain Homo sapiens 35-45 6460044-3 1982 The formation of this GPIIb-GPIIIa fibrinogen complex is calcium dependent, fibrinogen specific, saturable, and inhibited by specific amino sugars and amino acids. Calcium 57-64 fibrinogen beta chain Homo sapiens 76-86 6460044-3 1982 The formation of this GPIIb-GPIIIa fibrinogen complex is calcium dependent, fibrinogen specific, saturable, and inhibited by specific amino sugars and amino acids. Amino Sugars 134-146 fibrinogen beta chain Homo sapiens 35-45 6460044-3 1982 The formation of this GPIIb-GPIIIa fibrinogen complex is calcium dependent, fibrinogen specific, saturable, and inhibited by specific amino sugars and amino acids. Amino Sugars 134-146 fibrinogen beta chain Homo sapiens 76-86 7082649-2 1982 Factor XIIIa has been employed to enzymatically incorporate 1-6 mol of dansylcadaverine/mol of fibrinogen into a specific glutamine residue near the carboxy terminus of the gamma chain and up to two sites on the alpha chain. Glutamine 122-131 fibrinogen beta chain Homo sapiens 95-105 7055572-1 1982 Fibrinogen absorbed to zinc chelate columns at pH 7.8 and was eluted sharply with a pK of 5.8 indicative of the involvement of a histidine residue. Histidine 129-138 fibrinogen beta chain Homo sapiens 0-10 6181636-0 1982 [Isolation of an alpha-globulin from rabbit serum responsible for a cobalt(II) ion-induced change in conformation of fibrinogen]. Cobalt(2+) 68-78 fibrinogen beta chain Homo sapiens 117-127 6181636-1 1982 A change in conformation of fibrinogen, caused by cobaltous ions after parenteral application or incubation of plasma, is dependent on the presence of species specific plasma proteins. cobaltous 50-59 fibrinogen beta chain Homo sapiens 28-38 6274453-1 1982 Fibrinogen binds to specific receptors on human washed platelets and these sites are induced by adenosine diphosphate (ADP). Adenosine Diphosphate 96-117 fibrinogen beta chain Homo sapiens 0-10 6274453-1 1982 Fibrinogen binds to specific receptors on human washed platelets and these sites are induced by adenosine diphosphate (ADP). Adenosine Diphosphate 119-122 fibrinogen beta chain Homo sapiens 0-10 6274453-4 1982 In either citrated or heparinized PRP, association of fibrinogen with platelets was demonstrable and was dependent on ADP dose. Adenosine Diphosphate 118-121 fibrinogen beta chain Homo sapiens 54-64 6274453-11 1982 These results are similar to those obtained with washed platelets and establish that the previously defined steps in ADP-induced binding of fibrinogen to platelets occur in plasma, namely receptor induction by ADP, initial reversible binding, and irreversible binding. Adenosine Diphosphate 117-120 fibrinogen beta chain Homo sapiens 140-150 6274453-11 1982 These results are similar to those obtained with washed platelets and establish that the previously defined steps in ADP-induced binding of fibrinogen to platelets occur in plasma, namely receptor induction by ADP, initial reversible binding, and irreversible binding. Adenosine Diphosphate 210-213 fibrinogen beta chain Homo sapiens 140-150 6290353-0 1982 Fibrinogen-bound sialic acid levels in the dysfibrinogenaemia of liver disease. N-Acetylneuraminic Acid 17-28 fibrinogen beta chain Homo sapiens 0-10 6290353-1 1982 Fibrinogen-bound sialic acid levels were determined in 75 normal controls and 80 patients with liver disease. N-Acetylneuraminic Acid 17-28 fibrinogen beta chain Homo sapiens 0-10 7129234-1 1982 Fibrinogen-bound sialic acid was determined in a large series of normal adult, full-term pre-term cord blood samples. N-Acetylneuraminic Acid 17-28 fibrinogen beta chain Homo sapiens 0-10 7129234-2 1982 Sialic acid was significantly higher in the full-term cord fibrinogen than controls, and higher in premature than term samples. N-Acetylneuraminic Acid 0-11 fibrinogen beta chain Homo sapiens 59-69 7129234-5 1982 It is concluded that fetal fibrinogen is characterised by an elevated sialic acid content, and that the degree of hypersialation is a function of gestational age. N-Acetylneuraminic Acid 70-81 fibrinogen beta chain Homo sapiens 27-37 7077179-0 1982 [The detection of deep venous thrombosis by fibrinogen labelled with iodine 125. Iodine-125 69-79 fibrinogen beta chain Homo sapiens 44-54 6460338-4 1981 Treatment with sulphinpyrazone resulted in lengthening of both platelet and fibrinogen survival, a rise in ATIII but no change in the beta tg or PF4 concentrations. Sulfinpyrazone 15-30 fibrinogen beta chain Homo sapiens 76-86 7332108-2 1981 But by using human fibrinogen labeled with radioactive iodine (125I), despite its limitations in detecting thrombi proximal to the femoral veins, we were able to demonstrate those which were still at the subclinical stage of the disease process apart from overt cases of deep vein thrombosis (DVT). radioactive iodine 43-61 fibrinogen beta chain Homo sapiens 19-29 7332108-2 1981 But by using human fibrinogen labeled with radioactive iodine (125I), despite its limitations in detecting thrombi proximal to the femoral veins, we were able to demonstrate those which were still at the subclinical stage of the disease process apart from overt cases of deep vein thrombosis (DVT). Iodine-125 63-67 fibrinogen beta chain Homo sapiens 19-29 7295738-0 1981 The release of carbohydrate moieties from human fibrinogen by almond glycopeptidase without alteration in fibrinogen clottability. Carbohydrates 15-27 fibrinogen beta chain Homo sapiens 48-58 7295738-2 1981 40% of the total neutral sugars was removed from the desialylated fibrinogen. Sugars 25-31 fibrinogen beta chain Homo sapiens 66-76 7295738-6 1981 The results suggest that the carbohydrate moiety of fibrinogen is not involved in the clotting mechanism. Carbohydrates 29-41 fibrinogen beta chain Homo sapiens 52-62 7295738-7 1981 Oligosaccharide was detected in the glyopeptidase digest of desialylated fibrinogen by thin-layer chromatography (TLC), and was found to be identical with those released quantitatively from the peptic digests of beta- and gamma-polypeptide chains. Oligosaccharides 0-15 fibrinogen beta chain Homo sapiens 73-83 7272509-0 1981 ADP and epinephrine-induced release of platelet fibrinogen. Epinephrine 8-19 fibrinogen beta chain Homo sapiens 48-58 7272509-3 1981 With addition of ADP or epinephrine, biphasic aggregation was seen, with release of platelet fibrinogen, beta-thromboglobulin, and platelet factor 4. Adenosine Diphosphate 17-20 fibrinogen beta chain Homo sapiens 93-103 7272509-3 1981 With addition of ADP or epinephrine, biphasic aggregation was seen, with release of platelet fibrinogen, beta-thromboglobulin, and platelet factor 4. Epinephrine 24-35 fibrinogen beta chain Homo sapiens 93-103 7272509-7 1981 The ability of gel-filtered platelets to undergo ADP- and epinephrine-induced aggregation and release in the absence of exogenous fibrinogen suggests that released platelet fibrinogen may be able to fulfill the requirement for fibrinogen in ADP- and epinephrine-induced platelet aggregation and release. Adenosine Diphosphate 49-52 fibrinogen beta chain Homo sapiens 173-183 7272509-7 1981 The ability of gel-filtered platelets to undergo ADP- and epinephrine-induced aggregation and release in the absence of exogenous fibrinogen suggests that released platelet fibrinogen may be able to fulfill the requirement for fibrinogen in ADP- and epinephrine-induced platelet aggregation and release. Adenosine Diphosphate 49-52 fibrinogen beta chain Homo sapiens 173-183 7272509-7 1981 The ability of gel-filtered platelets to undergo ADP- and epinephrine-induced aggregation and release in the absence of exogenous fibrinogen suggests that released platelet fibrinogen may be able to fulfill the requirement for fibrinogen in ADP- and epinephrine-induced platelet aggregation and release. Epinephrine 58-69 fibrinogen beta chain Homo sapiens 173-183 7272509-7 1981 The ability of gel-filtered platelets to undergo ADP- and epinephrine-induced aggregation and release in the absence of exogenous fibrinogen suggests that released platelet fibrinogen may be able to fulfill the requirement for fibrinogen in ADP- and epinephrine-induced platelet aggregation and release. Epinephrine 58-69 fibrinogen beta chain Homo sapiens 173-183 7272509-7 1981 The ability of gel-filtered platelets to undergo ADP- and epinephrine-induced aggregation and release in the absence of exogenous fibrinogen suggests that released platelet fibrinogen may be able to fulfill the requirement for fibrinogen in ADP- and epinephrine-induced platelet aggregation and release. Adenosine Diphosphate 241-244 fibrinogen beta chain Homo sapiens 173-183 7272509-7 1981 The ability of gel-filtered platelets to undergo ADP- and epinephrine-induced aggregation and release in the absence of exogenous fibrinogen suggests that released platelet fibrinogen may be able to fulfill the requirement for fibrinogen in ADP- and epinephrine-induced platelet aggregation and release. Adenosine Diphosphate 241-244 fibrinogen beta chain Homo sapiens 173-183 7272509-7 1981 The ability of gel-filtered platelets to undergo ADP- and epinephrine-induced aggregation and release in the absence of exogenous fibrinogen suggests that released platelet fibrinogen may be able to fulfill the requirement for fibrinogen in ADP- and epinephrine-induced platelet aggregation and release. Epinephrine 250-261 fibrinogen beta chain Homo sapiens 173-183 7272509-7 1981 The ability of gel-filtered platelets to undergo ADP- and epinephrine-induced aggregation and release in the absence of exogenous fibrinogen suggests that released platelet fibrinogen may be able to fulfill the requirement for fibrinogen in ADP- and epinephrine-induced platelet aggregation and release. Epinephrine 250-261 fibrinogen beta chain Homo sapiens 173-183 6797089-0 1981 The in vitro effect of ticlopidine on fibrinogen and factor VIII binding to human platelets. Ticlopidine 23-34 fibrinogen beta chain Homo sapiens 38-48 6797089-4 1981 125I-fibrinogen binding was measured in suspensions of freshly-washed normal platelets stimulated by 10 microM ADP or 10 microM adrenaline. Adenosine Diphosphate 111-114 fibrinogen beta chain Homo sapiens 5-15 6797089-4 1981 125I-fibrinogen binding was measured in suspensions of freshly-washed normal platelets stimulated by 10 microM ADP or 10 microM adrenaline. Epinephrine 128-138 fibrinogen beta chain Homo sapiens 5-15 6797089-6 1981 Ticlopidine at final concentrations of 200, 100, 50 and 25 microM inhibited both ADP and adrenaline-induced fibrinogen binding in a dose-dependent manner. Ticlopidine 0-11 fibrinogen beta chain Homo sapiens 108-118 6797089-6 1981 Ticlopidine at final concentrations of 200, 100, 50 and 25 microM inhibited both ADP and adrenaline-induced fibrinogen binding in a dose-dependent manner. Epinephrine 89-99 fibrinogen beta chain Homo sapiens 108-118 6797089-7 1981 The mean % inhibition of ADP-induced fibrinogen binding was 82, 73, 42 and 32 respectively. Adenosine Diphosphate 25-28 fibrinogen beta chain Homo sapiens 37-47 6797089-8 1981 The mean % inhibition of adrenaline-induced fibrinogen binding was 86, 82, 60 and 35 respectively. Epinephrine 25-35 fibrinogen beta chain Homo sapiens 44-54 6797089-10 1981 These results suggest that ticlopidine either inhibits platelet activation and consequently fibrinogen binding, or inhibits the binding directly, presumably by having an effect on the specific configuration of the platelet membrane required for normal fibrinogen binding. Ticlopidine 27-38 fibrinogen beta chain Homo sapiens 92-102 6797089-10 1981 These results suggest that ticlopidine either inhibits platelet activation and consequently fibrinogen binding, or inhibits the binding directly, presumably by having an effect on the specific configuration of the platelet membrane required for normal fibrinogen binding. Ticlopidine 27-38 fibrinogen beta chain Homo sapiens 252-262 7314054-1 1981 The properties of human fibrinogen labeled with 125-Iodine using Iodogen (1, 3, 4, 6-tetrachloro-3 alpha, 6 alpha-diphenylglycoluril) as an oxidizing agent were compared with those of an iodine monochloride labeled counterpart. Iodine-125 48-58 fibrinogen beta chain Homo sapiens 24-34 7314054-4 1981 It is concluded that human fibrinogen labeled with radioiodine using the Iodogen technique is suitable for studies in vitro and in vivo. Iodine-131 51-62 fibrinogen beta chain Homo sapiens 27-37 6978209-2 1981 The difference in 125I-Clq binding was due to the presence of fibrinogen in plasma. 125i-clq 18-26 fibrinogen beta chain Homo sapiens 62-72 6978209-3 1981 It was shown that complex formation between fibrinogen and 125I-Clq occurs and that this complex precipitates in the presence of polyethylene glycol, leading to the false positive results in the ClqBA. 125i-clq 59-67 fibrinogen beta chain Homo sapiens 44-54 7117668-0 1982 Inhibition of thrombin cleavage of fibrinogen by polyestradiol phosphate; interaction with the crucial arginine residues in fibrinogen required for enzymic cleavage. polyestradiol phosphate 49-72 fibrinogen beta chain Homo sapiens 35-45 7117668-0 1982 Inhibition of thrombin cleavage of fibrinogen by polyestradiol phosphate; interaction with the crucial arginine residues in fibrinogen required for enzymic cleavage. polyestradiol phosphate 49-72 fibrinogen beta chain Homo sapiens 124-134 7117668-0 1982 Inhibition of thrombin cleavage of fibrinogen by polyestradiol phosphate; interaction with the crucial arginine residues in fibrinogen required for enzymic cleavage. Arginine 103-111 fibrinogen beta chain Homo sapiens 35-45 7117668-0 1982 Inhibition of thrombin cleavage of fibrinogen by polyestradiol phosphate; interaction with the crucial arginine residues in fibrinogen required for enzymic cleavage. Arginine 103-111 fibrinogen beta chain Homo sapiens 124-134 7289572-0 1981 [Blood fibrinogen during 7-day water immersion and short-term space flight]. Water 31-36 fibrinogen beta chain Homo sapiens 7-17 6789679-3 1981 Of the coagulation parameters, the fibrinogen level increased significantly from an initial value of 248 +/- 11.7 mg/dl (mean +/- SEM) to 353 +/- 32.2 mg/dl after hMG treatment (P less than 0.05), with a significant positive correlation between estrogen and fibrinogen levels (r = +0.762). Menotropins 163-166 fibrinogen beta chain Homo sapiens 35-45 6789679-3 1981 Of the coagulation parameters, the fibrinogen level increased significantly from an initial value of 248 +/- 11.7 mg/dl (mean +/- SEM) to 353 +/- 32.2 mg/dl after hMG treatment (P less than 0.05), with a significant positive correlation between estrogen and fibrinogen levels (r = +0.762). Menotropins 163-166 fibrinogen beta chain Homo sapiens 258-268 6265056-5 1981 Patient fibrinogen purified with 2.1 M glycine migrated normally on immunoelectrophoresis and 7.5% polyacrylamide-SDS gel electrophoresis. Glycine 39-46 fibrinogen beta chain Homo sapiens 8-18 7061918-9 1982 The administration of heparin to cirrhotic patients improved the survival of fibrinogen but not of platelets. Heparin 22-29 fibrinogen beta chain Homo sapiens 77-87 6456216-1 1981 Influence of calcium on the generation of fibrinogen degradation products with anticlotting properties. Calcium 13-20 fibrinogen beta chain Homo sapiens 42-52 6456216-2 1981 Degradation of human fibrinogen by elastase-like proteinase, chymotrypsin-like proteinase and plasmin, was done in the presence and absence of calcium ions, respectively. Calcium 143-150 fibrinogen beta chain Homo sapiens 21-31 6456216-7 1981 The fibrinogen fragments obtained in the presence of calcium are different in their molecular weights and anticoagulant activities compared to those obtained in the absence of calcium ions. Calcium 53-60 fibrinogen beta chain Homo sapiens 4-14 6456216-7 1981 The fibrinogen fragments obtained in the presence of calcium are different in their molecular weights and anticoagulant activities compared to those obtained in the absence of calcium ions. Calcium 176-183 fibrinogen beta chain Homo sapiens 4-14 6456216-8 1981 This effect of calcium is most striking during fibrinogen cleavage by chymotrypsin-like proteinase. Calcium 15-22 fibrinogen beta chain Homo sapiens 47-57 6978209-3 1981 It was shown that complex formation between fibrinogen and 125I-Clq occurs and that this complex precipitates in the presence of polyethylene glycol, leading to the false positive results in the ClqBA. Polyethylene Glycols 129-148 fibrinogen beta chain Homo sapiens 44-54 6785097-2 1981 131-iodine labelled fibrinogen and 125-iodine labelled plasminogen were injected intravenously and the plasma clearance of the two proteins measured simultaneously over a period of 8 days. Iodine-131 0-10 fibrinogen beta chain Homo sapiens 20-30 7281105-5 1981 Mepacrine inhibited ADP-induced platelet aggregation by inhibiting the association of fibrinogen with platelets during aggregation. Quinacrine 0-9 fibrinogen beta chain Homo sapiens 86-96 7281105-5 1981 Mepacrine inhibited ADP-induced platelet aggregation by inhibiting the association of fibrinogen with platelets during aggregation. Adenosine Diphosphate 20-23 fibrinogen beta chain Homo sapiens 86-96 7281105-6 1981 The effect of mepacrine on fibrinogen binding could be considerably decreased by washing the platelets but the inhibition of 14C loss persisted. Quinacrine 14-23 fibrinogen beta chain Homo sapiens 27-37 7281105-8 1981 Thus, mepacrine has two effects; 1. it inhibits phospholipases, 2. it inhibits fibrinogen binding. Quinacrine 6-15 fibrinogen beta chain Homo sapiens 79-89 6910459-0 1981 [Monitoring of post-operative prevention of thrombosis by low dosage heparin with the radioactive iodine fibrinogen test (author"s transl)]. Heparin 69-76 fibrinogen beta chain Homo sapiens 105-115 6910459-0 1981 [Monitoring of post-operative prevention of thrombosis by low dosage heparin with the radioactive iodine fibrinogen test (author"s transl)]. radioactive iodine 86-104 fibrinogen beta chain Homo sapiens 105-115 6910459-5 1981 Because of the early occurrence of silent signs of deep vein thrombosis in the radioactive iodine fibrinogen test the onset of the subcutaneous heparin prophylaxis of thrombosis was shifted from the post-operative period to the pre-operative administration. Heparin 144-151 fibrinogen beta chain Homo sapiens 98-108 7348274-4 1981 Previous studies have indicated differences in the affinity of various proteins for a given polymer, and differences in the affinity of fibrinogen for a series of polymers varying in hydrophilicity. Polymers 163-171 fibrinogen beta chain Homo sapiens 136-146 7209542-1 1981 The affinity of the amino terminal tetrapeptide of the beta chain of fibrin, Gly-His-Arg-Pro, for fibrinogen dramatically increases in the presence of 2 millimolar calcium ion. Histidine 81-84 fibrinogen beta chain Homo sapiens 98-108 7209542-1 1981 The affinity of the amino terminal tetrapeptide of the beta chain of fibrin, Gly-His-Arg-Pro, for fibrinogen dramatically increases in the presence of 2 millimolar calcium ion. Arginine 85-88 fibrinogen beta chain Homo sapiens 98-108 7209542-1 1981 The affinity of the amino terminal tetrapeptide of the beta chain of fibrin, Gly-His-Arg-Pro, for fibrinogen dramatically increases in the presence of 2 millimolar calcium ion. Proline 89-92 fibrinogen beta chain Homo sapiens 98-108 7209542-1 1981 The affinity of the amino terminal tetrapeptide of the beta chain of fibrin, Gly-His-Arg-Pro, for fibrinogen dramatically increases in the presence of 2 millimolar calcium ion. Calcium 164-171 fibrinogen beta chain Homo sapiens 98-108 6458117-0 1981 Human fibrinogen binds EDTA and citrate. Edetic Acid 23-27 fibrinogen beta chain Homo sapiens 6-16 6458117-0 1981 Human fibrinogen binds EDTA and citrate. Citric Acid 32-39 fibrinogen beta chain Homo sapiens 6-16 6452172-2 1981 The previously described protective effect of calcium ions on the gamma-chain carboxy-terminals of fibrinogen against attack has been confirmed by working at high plasmin concentrations and/or in the presence of 2 M urea. Calcium 46-53 fibrinogen beta chain Homo sapiens 99-109 7209542-0 1981 Influence of calcium ion on the binding of fibrin amino terminal peptides to fibrinogen. Calcium 13-20 fibrinogen beta chain Homo sapiens 77-87 7209542-1 1981 The affinity of the amino terminal tetrapeptide of the beta chain of fibrin, Gly-His-Arg-Pro, for fibrinogen dramatically increases in the presence of 2 millimolar calcium ion. Glycine 77-80 fibrinogen beta chain Homo sapiens 98-108 6781433-4 1981 Low dose heparin (0,15 to 0,20 ml x 2/day by subcutaneous injection) led to normalisation of the fibrinogen levels, increased the platelet count and reversed the consumptive coagulopathy. Heparin 9-16 fibrinogen beta chain Homo sapiens 97-107 7297771-3 1981 The most striking abnormality of coagulation described in diabetes mellitus is a decrement in fibrinogen survival that is rapidly reversible with correction of hyperglycemia or the administration of heparin but not with aspirin and dipyridamole administration, suggesting a hypercoagulable state. Heparin 199-206 fibrinogen beta chain Homo sapiens 94-104 7274778-1 1981 Glucose, when incubated with fibrinogen, binds covalently to that protein. Glucose 0-7 fibrinogen beta chain Homo sapiens 29-39 7027278-2 1981 Blood fibrinogen levels are increased and the endogenous fibrinolytic activity decreased by conditions or factors which raise plasma free fatty acid levels. Fatty Acids, Nonesterified 133-148 fibrinogen beta chain Homo sapiens 6-16 7336352-0 1981 [Quantitative and qualitative composition of sterol from fibrinogen and erythrocyte membranes in kidney diseases]. Sterols 45-51 fibrinogen beta chain Homo sapiens 57-67 7350149-0 1980 Interaction of fibrinogen with its platelet receptor as part of a multistep reaction in ADP-induced platelet aggregation. Adenosine Diphosphate 88-91 fibrinogen beta chain Homo sapiens 15-25 7386774-0 1980 [Changes in the fibrinogen level and the risk of defibrination after the intra-amniotic instillation of a saline solution used for abortion purposes]. Sodium Chloride 106-112 fibrinogen beta chain Homo sapiens 16-26 6165239-10 1980 His unreduced purified fibrinogen had normal migration on polyacrylamide slab gels. polyacrylamide 58-72 fibrinogen beta chain Homo sapiens 23-33 6165239-11 1980 Also, the migration in gel slabs of A alpha, B beta and gamma-polypeptide chains, produced by mercaptoethanol reduction of purified patient fibrinogen, was similar to reduced normal fibrinogen. Mercaptoethanol 94-109 fibrinogen beta chain Homo sapiens 140-150 7435500-5 1980 When a physiologic level of human fibrinogen was added to the CA platelets in autologous plasma or to the washed platelets in balanced saline, the times to aggregation were significantly shortened (P < 0.05) and restored to rates comparable to those of normal platelets in whole plasma. balanced saline 126-141 fibrinogen beta chain Homo sapiens 34-44 7212396-0 1980 [Interference of fibrinogen in the determination of plasma urea by the o-phthalaldehyde method]. Urea 59-63 fibrinogen beta chain Homo sapiens 17-27 7212396-0 1980 [Interference of fibrinogen in the determination of plasma urea by the o-phthalaldehyde method]. o-Phthalaldehyde 71-87 fibrinogen beta chain Homo sapiens 17-27 7224247-0 1980 Adsorption of human fibrinogen and human serum albumin onto polyethylene. Polyethylene 60-72 fibrinogen beta chain Homo sapiens 20-30 6162435-3 1980 Nine subjects with asymptomatic hyperlipidemia, hyperfibrinogenemia and exercise ST segment depressions were treated with clofibrate in order to lower plasma fibrinogen and serum lipids. Clofibrate 122-132 fibrinogen beta chain Homo sapiens 53-63 7362845-0 1980 Interaction of polyamines with proteins of human plasma: a preferential aggregation of fibrinogen and fibronectin (cold insoluble globulin). Polyamines 15-25 fibrinogen beta chain Homo sapiens 87-97 7362845-3 1980 The results indicate that fibrinogen and fibronectin have anionic groups which react with polyamines and which are essential for the solubility of these proteins. Polyamines 90-100 fibrinogen beta chain Homo sapiens 26-36 7378042-2 1980 The fibrin polymers formed in solution during the earliest phase of the fibrinogen-fibrin conversion are shown to be stable soluble molecules at pH7.4 and 0.15m- or 0.3m-NaCl. Sodium Chloride 170-174 fibrinogen beta chain Homo sapiens 72-82 7378042-13 1980 This mechanism accounts for the clinical observations of stable fibrinogen-derived polymers in the plasma from patients undergoing thrombotic processes. Polymers 83-91 fibrinogen beta chain Homo sapiens 64-74 7350935-1 1980 Using ellipsometry, anodized tantalum interference color, and Coomassie blue staining in conjunction with immunologic identification of proteins adsorbed at interfaces, we have previously found that fibrinogen is the main constituent deposited by plasma onto many man-made surfaces. Coomassie blue 62-76 fibrinogen beta chain Homo sapiens 199-209 6155267-5 1980 In patients with the lowest fibrinogen T/2 and platelet count, heparin infusion therapy returned the fibrinogen half-life to normal range. Heparin 63-70 fibrinogen beta chain Homo sapiens 28-38 6155267-5 1980 In patients with the lowest fibrinogen T/2 and platelet count, heparin infusion therapy returned the fibrinogen half-life to normal range. Heparin 63-70 fibrinogen beta chain Homo sapiens 101-111 6264421-2 1980 Preliminary data (accumulation of 125I-labelled fibrinogen in two and morphology of the graft in two other patients) showed that depression of graft function in cytomegaly is not necessarily due to rejection. Iodine-125 34-38 fibrinogen beta chain Homo sapiens 48-58 6781049-0 1980 Fibrinogen: a rapid electroimmunoassay method on cellulose acetate. acetylcellulose 49-66 fibrinogen beta chain Homo sapiens 0-10 6792695-3 1980 Highly purified fibrinogen used as detector reagent instead of plasma was sufficient to elicit a precipitation zone similar to that of the DP reaction. dp 139-141 fibrinogen beta chain Homo sapiens 16-26 540036-1 1979 Fibrinogen-fibrin-related antigen (FR antigen) was isolated from as little as 1 ml of human plasma by immuno-affinity chromatography with agarose-bound antibody to human fibrinogen. Sepharose 138-145 fibrinogen beta chain Homo sapiens 0-10 540036-1 1979 Fibrinogen-fibrin-related antigen (FR antigen) was isolated from as little as 1 ml of human plasma by immuno-affinity chromatography with agarose-bound antibody to human fibrinogen. Sepharose 138-145 fibrinogen beta chain Homo sapiens 170-180 540036-3 1979 Thrombin cleavage of the A- and B-peptides from fibrinogen in vitro was monitored by the appearance of N-terminal glycine, and an increase in glycine was shown in the FR antigen of patients with disseminated intravascular coagulation. Glycine 114-121 fibrinogen beta chain Homo sapiens 48-58 540036-3 1979 Thrombin cleavage of the A- and B-peptides from fibrinogen in vitro was monitored by the appearance of N-terminal glycine, and an increase in glycine was shown in the FR antigen of patients with disseminated intravascular coagulation. Glycine 142-149 fibrinogen beta chain Homo sapiens 48-58 518844-2 1979 The largest fragment produced by complete cyanogen bromide digestion of the alpha chain of human fibrinogen contains 236 residues and has a calculated molecular weight of 23,949. Cyanogen Bromide 42-58 fibrinogen beta chain Homo sapiens 97-107 497123-0 1979 Electron microscopy of metal-shadowed fibrinogen molecules deposited at different concentrations. Metals 23-28 fibrinogen beta chain Homo sapiens 38-48 497404-0 1979 Comparison of fibrinogen association with normal and thrombasthenic platelets on exposure to ADP or chymotrypsin. Adenosine Diphosphate 93-96 fibrinogen beta chain Homo sapiens 14-24 500818-0 1979 Sequence of fibrinogen proteolysis and platelet release after intrauterine infusion of hypertonic saline. intrauterine 62-74 fibrinogen beta chain Homo sapiens 12-22 500818-8 1979 The data indicate that immediately after intrauterine hypertonic saline infusion thrombin is formed that cleaves FPA from fibrinogen to produce fibrin I and releases betaTG and PF4 from platelets. Sodium Chloride 65-71 fibrinogen beta chain Homo sapiens 122-132 574143-1 1979 The role of fibrinogen as a cofactor for platelet aggregation was examined by measuring the binding of 125I-labeled human fibrinogen to gel-filtered human platelets both before and after platelet stimulation by ADP and epinephrine. Iodine-125 103-107 fibrinogen beta chain Homo sapiens 122-132 574143-2 1979 Platelet stimulation by ADP resulted in the rapid, reversible binding of fibrinogen to receptors on the platelet surface. Adenosine Diphosphate 24-27 fibrinogen beta chain Homo sapiens 73-83 574143-3 1979 Fibrinogen binding increased as the concentration of ADP was increased from 0.1 to 2 microM, reaching a plateau at higher ADP concentrations. Adenosine Diphosphate 53-56 fibrinogen beta chain Homo sapiens 0-10 574143-3 1979 Fibrinogen binding increased as the concentration of ADP was increased from 0.1 to 2 microM, reaching a plateau at higher ADP concentrations. Adenosine Diphosphate 122-125 fibrinogen beta chain Homo sapiens 0-10 574143-7 1979 These fibrinogen binding parameters were essentially the same whether ADP or epinephrine was the platelet-stimulating agent. Adenosine Diphosphate 70-73 fibrinogen beta chain Homo sapiens 6-16 574143-8 1979 Thus, these studies demonstrate that platelet stimulation by ADP and epinephrine exposes a limited number of fibrinogen receptors on the platelet surface. Adenosine Diphosphate 61-64 fibrinogen beta chain Homo sapiens 109-119 574143-8 1979 Thus, these studies demonstrate that platelet stimulation by ADP and epinephrine exposes a limited number of fibrinogen receptors on the platelet surface. Epinephrine 69-80 fibrinogen beta chain Homo sapiens 109-119 41337-4 1979 Furthermore, thrombin adsorbed onto behenic acid was active in the sense that it coagulated fibrinogen. behenic acid 36-48 fibrinogen beta chain Homo sapiens 92-102 505412-2 1979 The fibrinogen is characterized by (1) abnormal side-to-side and end-to-end polymerization, (2) abnormal fibrinopeptide release, (3) a delayed gamma-gamma dimerization of the non cross-linked fibrin, (4) a pH optimum of 7--7.8, and (5) a deviation from normal amino acid composition with regard to lysine, aspartic acid, glutamic acid and serine. Lysine 298-304 fibrinogen beta chain Homo sapiens 4-14 505412-2 1979 The fibrinogen is characterized by (1) abnormal side-to-side and end-to-end polymerization, (2) abnormal fibrinopeptide release, (3) a delayed gamma-gamma dimerization of the non cross-linked fibrin, (4) a pH optimum of 7--7.8, and (5) a deviation from normal amino acid composition with regard to lysine, aspartic acid, glutamic acid and serine. Aspartic Acid 306-319 fibrinogen beta chain Homo sapiens 4-14 505412-2 1979 The fibrinogen is characterized by (1) abnormal side-to-side and end-to-end polymerization, (2) abnormal fibrinopeptide release, (3) a delayed gamma-gamma dimerization of the non cross-linked fibrin, (4) a pH optimum of 7--7.8, and (5) a deviation from normal amino acid composition with regard to lysine, aspartic acid, glutamic acid and serine. Glutamic Acid 321-334 fibrinogen beta chain Homo sapiens 4-14 505412-2 1979 The fibrinogen is characterized by (1) abnormal side-to-side and end-to-end polymerization, (2) abnormal fibrinopeptide release, (3) a delayed gamma-gamma dimerization of the non cross-linked fibrin, (4) a pH optimum of 7--7.8, and (5) a deviation from normal amino acid composition with regard to lysine, aspartic acid, glutamic acid and serine. Serine 339-345 fibrinogen beta chain Homo sapiens 4-14 11496383-0 1979 [Evaluation of bone scintigraphy with pyrophosphate and fibrinogen labeled with technetium 99m in rheumatoid arthritis and other arthropathies]. Technetium-99 80-93 fibrinogen beta chain Homo sapiens 56-66 476620-1 1979 Previous work in our laboratory has indicated that free fatty acids stimulate synthesis of fibrinogen by the liver. Fatty Acids, Nonesterified 51-67 fibrinogen beta chain Homo sapiens 91-101 476620-2 1979 The effect of the hypolipidemic agent clofibrate on hyperfibrinogenemia associated with tumors was evaluated by monitoring clofibrate-induced changes in plasma fibrinogen concentration and biosynthesis of the protein in Buffalo rats implanted with a localized, nonmetastasizing neoplasm derived from a tumorigenic hepatoma cell line (HTC4). Clofibrate 38-48 fibrinogen beta chain Homo sapiens 57-67 476620-5 1979 Treatment with clofibrate in doses which normalized the plasma free fatty acid/albumin ratio also prevented the tumor-associated rise in plasma fibrinogen. Clofibrate 15-25 fibrinogen beta chain Homo sapiens 144-154 476620-5 1979 Treatment with clofibrate in doses which normalized the plasma free fatty acid/albumin ratio also prevented the tumor-associated rise in plasma fibrinogen. Fatty Acids, Nonesterified 63-78 fibrinogen beta chain Homo sapiens 144-154 476620-6 1979 Rates of fibrinogen synthesis were lowered significantly in clofibrate-treated animals. Clofibrate 60-70 fibrinogen beta chain Homo sapiens 9-19 476620-9 1979 Thus, treatment with clofibrate or other hypolipidemic agents should be evaluated in cancer patients with elevated plasma fibrinogen levels and their attendant complications. Clofibrate 21-31 fibrinogen beta chain Homo sapiens 122-132 482913-0 1979 [Importance of the sialic acid moiety for the heterogeneity in human fibrinogen]. N-Acetylneuraminic Acid 19-30 fibrinogen beta chain Homo sapiens 69-79 482913-5 1979 The difference in sialic acid content of the gamma- and B beta-chain variants of human fibrinogen therefore explains on part of the polypeptide chain heterogeneity. N-Acetylneuraminic Acid 18-29 fibrinogen beta chain Homo sapiens 87-97 6453618-0 1981 Anticoagulant and calcium-binding properties of high molecular weight derivatives of human fibrinogen, produced by plasmin (fragments X). Calcium 18-25 fibrinogen beta chain Homo sapiens 91-101 7245128-1 1981 From the coagulocytes (amoebocytes) coagulogen (fibrinogen) was isolated, and purified on Sephacryl S-200. sephacryl S 200 90-105 fibrinogen beta chain Homo sapiens 48-58 6161550-11 1981 Of the different methods used to detect deep venous thrombosis, iodine-125 fibrinogen scanning was superior to both impedance plethysmography and venous Doppler ultrasound. Iodine 64-70 fibrinogen beta chain Homo sapiens 75-85 7213792-3 1981 When a solution of fibrinogen containing fluorescein and 3H-labeled tryptophan was illuminated with visible light, radioactive labeling of fibrinogen occurred in proportion to the illumination time. Fluorescein 41-52 fibrinogen beta chain Homo sapiens 19-29 7213792-3 1981 When a solution of fibrinogen containing fluorescein and 3H-labeled tryptophan was illuminated with visible light, radioactive labeling of fibrinogen occurred in proportion to the illumination time. Fluorescein 41-52 fibrinogen beta chain Homo sapiens 139-149 7213792-3 1981 When a solution of fibrinogen containing fluorescein and 3H-labeled tryptophan was illuminated with visible light, radioactive labeling of fibrinogen occurred in proportion to the illumination time. Tritium 57-59 fibrinogen beta chain Homo sapiens 19-29 7213792-3 1981 When a solution of fibrinogen containing fluorescein and 3H-labeled tryptophan was illuminated with visible light, radioactive labeling of fibrinogen occurred in proportion to the illumination time. Tritium 57-59 fibrinogen beta chain Homo sapiens 139-149 7213792-3 1981 When a solution of fibrinogen containing fluorescein and 3H-labeled tryptophan was illuminated with visible light, radioactive labeling of fibrinogen occurred in proportion to the illumination time. Tryptophan 68-78 fibrinogen beta chain Homo sapiens 19-29 7213792-3 1981 When a solution of fibrinogen containing fluorescein and 3H-labeled tryptophan was illuminated with visible light, radioactive labeling of fibrinogen occurred in proportion to the illumination time. Tryptophan 68-78 fibrinogen beta chain Homo sapiens 139-149 7459607-7 1981 Treatment of 10 patients with stanozolol, a stimulator of fibrinolysis, reduced the plasma fibrinogen and increased the haematocrit did not change the whole blood viscosity. Stanozolol 30-40 fibrinogen beta chain Homo sapiens 91-101 7016738-7 1981 Adsorption of fibrinogen was accomplished using a 0.05 M phosphate/0.2 M NaCl/0.02% NaN3/pH 7.0 buffer system followed by elution with 0.05 M PO4/1 M NaCl/0.02% NaN3 to remove non specifically bound components. Phosphates 57-66 fibrinogen beta chain Homo sapiens 14-24 7016738-7 1981 Adsorption of fibrinogen was accomplished using a 0.05 M phosphate/0.2 M NaCl/0.02% NaN3/pH 7.0 buffer system followed by elution with 0.05 M PO4/1 M NaCl/0.02% NaN3 to remove non specifically bound components. Sodium Chloride 73-77 fibrinogen beta chain Homo sapiens 14-24 7016738-7 1981 Adsorption of fibrinogen was accomplished using a 0.05 M phosphate/0.2 M NaCl/0.02% NaN3/pH 7.0 buffer system followed by elution with 0.05 M PO4/1 M NaCl/0.02% NaN3 to remove non specifically bound components. Sodium Azide 84-88 fibrinogen beta chain Homo sapiens 14-24 7016738-7 1981 Adsorption of fibrinogen was accomplished using a 0.05 M phosphate/0.2 M NaCl/0.02% NaN3/pH 7.0 buffer system followed by elution with 0.05 M PO4/1 M NaCl/0.02% NaN3 to remove non specifically bound components. po4 142-145 fibrinogen beta chain Homo sapiens 14-24 7016738-7 1981 Adsorption of fibrinogen was accomplished using a 0.05 M phosphate/0.2 M NaCl/0.02% NaN3/pH 7.0 buffer system followed by elution with 0.05 M PO4/1 M NaCl/0.02% NaN3 to remove non specifically bound components. Sodium Chloride 150-154 fibrinogen beta chain Homo sapiens 14-24 7016738-7 1981 Adsorption of fibrinogen was accomplished using a 0.05 M phosphate/0.2 M NaCl/0.02% NaN3/pH 7.0 buffer system followed by elution with 0.05 M PO4/1 M NaCl/0.02% NaN3 to remove non specifically bound components. Sodium Azide 161-165 fibrinogen beta chain Homo sapiens 14-24 7040863-3 1981 Biogenic glue consists of fibrinogen, factor XIII, and thrombin, which form a fibrin clot in the presence of calcium. Calcium 109-116 fibrinogen beta chain Homo sapiens 26-36 6941244-6 1981 Fragments from antibodies raised against a cyanogen bromide fragment of fibrinogen alpha chains (residues 241-476) also led to exclusive derivatization of the terminal domains, although in these cases the additional material was often separated discretely from the terminal sphere by a gap. Cyanogen Bromide 43-59 fibrinogen beta chain Homo sapiens 72-82 7466316-1 1981 During routine investigation of plasma proteins by agarose gel electrophoresis, a double fibrinogen band was found in a 79-year-old woman without previous history or clinical symptoms of bleeding tendency. Sepharose 51-58 fibrinogen beta chain Homo sapiens 89-99 6253495-0 1980 Induction of the fibrinogen receptor on human platelets by epinephrine and the combination of epinephrine and ADP. Epinephrine 59-70 fibrinogen beta chain Homo sapiens 17-27 6253495-0 1980 Induction of the fibrinogen receptor on human platelets by epinephrine and the combination of epinephrine and ADP. Epinephrine 94-105 fibrinogen beta chain Homo sapiens 17-27 6253495-0 1980 Induction of the fibrinogen receptor on human platelets by epinephrine and the combination of epinephrine and ADP. Adenosine Diphosphate 110-113 fibrinogen beta chain Homo sapiens 17-27 6253495-1 1980 The capacity of epinephrine alone and the combination of low dose epinephrine and ADP to support the binding of fibrinogen to washed human platelets has been examined, 125I-Fibrinogen was bound to epinephrine-stimulated platelets, but 90 min were required to achieve maximal binding at 22 degrees C in contrast to 20 to 30 min with ADP. Epinephrine 16-27 fibrinogen beta chain Homo sapiens 112-122 6253495-1 1980 The capacity of epinephrine alone and the combination of low dose epinephrine and ADP to support the binding of fibrinogen to washed human platelets has been examined, 125I-Fibrinogen was bound to epinephrine-stimulated platelets, but 90 min were required to achieve maximal binding at 22 degrees C in contrast to 20 to 30 min with ADP. Epinephrine 66-77 fibrinogen beta chain Homo sapiens 112-122 6253495-1 1980 The capacity of epinephrine alone and the combination of low dose epinephrine and ADP to support the binding of fibrinogen to washed human platelets has been examined, 125I-Fibrinogen was bound to epinephrine-stimulated platelets, but 90 min were required to achieve maximal binding at 22 degrees C in contrast to 20 to 30 min with ADP. Adenosine Diphosphate 82-85 fibrinogen beta chain Homo sapiens 112-122 6253495-1 1980 The capacity of epinephrine alone and the combination of low dose epinephrine and ADP to support the binding of fibrinogen to washed human platelets has been examined, 125I-Fibrinogen was bound to epinephrine-stimulated platelets, but 90 min were required to achieve maximal binding at 22 degrees C in contrast to 20 to 30 min with ADP. Epinephrine 66-77 fibrinogen beta chain Homo sapiens 112-122 6253495-2 1980 The overall rate of interaction appeared to reflect the slow binding of fibrinogen to epinephrine-stimulated platelets as opposed to the rate of stimulation of the cell. Epinephrine 86-97 fibrinogen beta chain Homo sapiens 72-82 6253495-4 1980 Fibrinogen binding was maximally supported by 20 to 30 microM epinephrine. Epinephrine 62-73 fibrinogen beta chain Homo sapiens 0-10 6253495-5 1980 The combination of low dose epinephrine (5 microM) and low dose ADP (0.5 microM), which acted synergistically to induce platelet aggregation, supported the rapid (10 min) binding of fibrinogen to platelets. Epinephrine 28-39 fibrinogen beta chain Homo sapiens 182-192 6253495-5 1980 The combination of low dose epinephrine (5 microM) and low dose ADP (0.5 microM), which acted synergistically to induce platelet aggregation, supported the rapid (10 min) binding of fibrinogen to platelets. Adenosine Diphosphate 64-67 fibrinogen beta chain Homo sapiens 182-192 6253495-6 1980 With 4 microM epinephrine, more fibrinogen bound per platelet at all ADP doses than with ADP alone. Epinephrine 14-25 fibrinogen beta chain Homo sapiens 32-42 6253495-6 1980 With 4 microM epinephrine, more fibrinogen bound per platelet at all ADP doses than with ADP alone. Adenosine Diphosphate 69-72 fibrinogen beta chain Homo sapiens 32-42 6253495-8 1980 The number of molecules bound per cell was stimulus-dependent, with 30 microM epinephrine inducing the binding of fewer fibrinogen molecules per cell (mean = 20,400) than 10 microM ADP (mean = 35,900) or the combination of 5 microM epinephrine + 0.5 microM ADP (mean = 43,600). Epinephrine 78-89 fibrinogen beta chain Homo sapiens 120-130 6253495-8 1980 The number of molecules bound per cell was stimulus-dependent, with 30 microM epinephrine inducing the binding of fewer fibrinogen molecules per cell (mean = 20,400) than 10 microM ADP (mean = 35,900) or the combination of 5 microM epinephrine + 0.5 microM ADP (mean = 43,600). Epinephrine 232-243 fibrinogen beta chain Homo sapiens 120-130 6253495-8 1980 The number of molecules bound per cell was stimulus-dependent, with 30 microM epinephrine inducing the binding of fewer fibrinogen molecules per cell (mean = 20,400) than 10 microM ADP (mean = 35,900) or the combination of 5 microM epinephrine + 0.5 microM ADP (mean = 43,600). Adenosine Diphosphate 257-260 fibrinogen beta chain Homo sapiens 120-130 6253495-9 1980 The participation of endogenous ADP in fibrinogen binding to epinephrine-stimulated platelets was suggested since enzymes which remove ADP, apyrase, and creatine phosphate/creatine phosphokinase, and the ADP analogue, 2-chloroadenosine, completely inhibited the binding of fibrinogen to the platelet. Adenosine Diphosphate 32-35 fibrinogen beta chain Homo sapiens 39-49 6253495-9 1980 The participation of endogenous ADP in fibrinogen binding to epinephrine-stimulated platelets was suggested since enzymes which remove ADP, apyrase, and creatine phosphate/creatine phosphokinase, and the ADP analogue, 2-chloroadenosine, completely inhibited the binding of fibrinogen to the platelet. Adenosine Diphosphate 32-35 fibrinogen beta chain Homo sapiens 273-283 6253495-9 1980 The participation of endogenous ADP in fibrinogen binding to epinephrine-stimulated platelets was suggested since enzymes which remove ADP, apyrase, and creatine phosphate/creatine phosphokinase, and the ADP analogue, 2-chloroadenosine, completely inhibited the binding of fibrinogen to the platelet. Epinephrine 61-72 fibrinogen beta chain Homo sapiens 39-49 6253495-9 1980 The participation of endogenous ADP in fibrinogen binding to epinephrine-stimulated platelets was suggested since enzymes which remove ADP, apyrase, and creatine phosphate/creatine phosphokinase, and the ADP analogue, 2-chloroadenosine, completely inhibited the binding of fibrinogen to the platelet. Epinephrine 61-72 fibrinogen beta chain Homo sapiens 273-283 6253495-9 1980 The participation of endogenous ADP in fibrinogen binding to epinephrine-stimulated platelets was suggested since enzymes which remove ADP, apyrase, and creatine phosphate/creatine phosphokinase, and the ADP analogue, 2-chloroadenosine, completely inhibited the binding of fibrinogen to the platelet. Adenosine Diphosphate 135-138 fibrinogen beta chain Homo sapiens 39-49 6253495-9 1980 The participation of endogenous ADP in fibrinogen binding to epinephrine-stimulated platelets was suggested since enzymes which remove ADP, apyrase, and creatine phosphate/creatine phosphokinase, and the ADP analogue, 2-chloroadenosine, completely inhibited the binding of fibrinogen to the platelet. 2-Chloroadenosine 218-235 fibrinogen beta chain Homo sapiens 39-49 6936572-4 1980 The laboratory findings in this case are commented upon, and particular emphasis is made on the measurement of coagulation factors II, V, VII-X, and VIII, the study of fibrin formation and fibrinolysis, and the changes in these parameters brought about by therapy with heparin, coagulation factors (fibrinogen, platelets), and cytostatic drugs. Heparin 269-276 fibrinogen beta chain Homo sapiens 299-309 7209886-0 1980 Identical behavior of fibrinogen and asialo-fibrinogen in reactions with platelets during ADP-induced aggregation. Adenosine Diphosphate 90-93 fibrinogen beta chain Homo sapiens 22-32 7209886-0 1980 Identical behavior of fibrinogen and asialo-fibrinogen in reactions with platelets during ADP-induced aggregation. Adenosine Diphosphate 90-93 fibrinogen beta chain Homo sapiens 44-54 6255944-0 1980 Phosphorylation of human fibrinogen in vitro with cyclic 3",5"-AMP-stimulated protein kinase and (32P)ATP. cyclic 3" 50-59 fibrinogen beta chain Homo sapiens 25-35 6255944-0 1980 Phosphorylation of human fibrinogen in vitro with cyclic 3",5"-AMP-stimulated protein kinase and (32P)ATP. Phosphorus-32 98-101 fibrinogen beta chain Homo sapiens 25-35 6255944-0 1980 Phosphorylation of human fibrinogen in vitro with cyclic 3",5"-AMP-stimulated protein kinase and (32P)ATP. Adenosine Triphosphate 102-105 fibrinogen beta chain Homo sapiens 25-35 7470571-1 1980 Polymerization was accomplished in the fibrinogen system by methylation with diazomethane, thionyl chloride and dimethyl sulphate. Diazomethane 77-89 fibrinogen beta chain Homo sapiens 39-49 7470571-1 1980 Polymerization was accomplished in the fibrinogen system by methylation with diazomethane, thionyl chloride and dimethyl sulphate. thionyl chloride 91-107 fibrinogen beta chain Homo sapiens 39-49 7470571-1 1980 Polymerization was accomplished in the fibrinogen system by methylation with diazomethane, thionyl chloride and dimethyl sulphate. dimethyl sulfate 112-129 fibrinogen beta chain Homo sapiens 39-49 7470571-3 1980 When fibrinogen was methylated with a very narrow range group-specific methylating agent, like dimethyl sulphate, the polymerization process was accelerated and proceeded with a reduction in the extent of modification of that obtained with the other methylating reagents utilized in these experiments. dimethyl sulfate 95-112 fibrinogen beta chain Homo sapiens 5-15 7470571-4 1980 Chromatographic analysis revealed that diazomethane and thionyl chloride induced both O-methylation and N-methylation, as well as esterification of the carboxylate groups of aspartic and glutamic acid in fibrinogen. Diazomethane 39-51 fibrinogen beta chain Homo sapiens 204-214 7470571-4 1980 Chromatographic analysis revealed that diazomethane and thionyl chloride induced both O-methylation and N-methylation, as well as esterification of the carboxylate groups of aspartic and glutamic acid in fibrinogen. thionyl chloride 56-72 fibrinogen beta chain Homo sapiens 204-214 7470571-4 1980 Chromatographic analysis revealed that diazomethane and thionyl chloride induced both O-methylation and N-methylation, as well as esterification of the carboxylate groups of aspartic and glutamic acid in fibrinogen. carboxylate 152-163 fibrinogen beta chain Homo sapiens 204-214 7470571-4 1980 Chromatographic analysis revealed that diazomethane and thionyl chloride induced both O-methylation and N-methylation, as well as esterification of the carboxylate groups of aspartic and glutamic acid in fibrinogen. Glutamic Acid 187-200 fibrinogen beta chain Homo sapiens 204-214 7466752-0 1980 Effect of fibrinogen on ADP-induced platelet aggregation. Adenosine Diphosphate 24-27 fibrinogen beta chain Homo sapiens 10-20 6933547-1 1980 Two types of normal human plasma fibrinogen--peak 1 and peak 2--are distinquishable by DEAE-cellulose gradient elution chromatography. DEAE-Cellulose 87-101 fibrinogen beta chain Homo sapiens 33-43 6160642-0 1980 Enhancement of plasminogen activation and hydrolysis of purified fibrinogen and fibrin by dextran 70. Dextrans 90-100 fibrinogen beta chain Homo sapiens 65-75 7400952-0 1980 Effect of sodium bicarbonate on in vitro conversion of fibrinogen to fibrin. Sodium Bicarbonate 10-28 fibrinogen beta chain Homo sapiens 55-65 7400952-1 1980 The effect of sodium bicarbonate on the conversion of fibrinogen to fibrin clot was investigated using fresh human whole blood and pure human fibrinogen. Sodium Bicarbonate 14-32 fibrinogen beta chain Homo sapiens 54-64 7391026-1 1980 Human fibrinogen was treated with thrombin in the presence of fibrinoligase and calcium ion at pH 8.5, ionic strength 0.45, and the ensuring polymerization was interrupted at various time intervals (t) both before and after the clotting time (tc) by solubilization with a solution of sodium dodecyl sulfate and urea. Calcium 80-87 fibrinogen beta chain Homo sapiens 6-16 7426889-0 1980 A method for determination of the depth of thrombi after injection of fibrinogen labelled with iodine 125. Iodine 95-101 fibrinogen beta chain Homo sapiens 70-80 7213845-0 1980 [Nature of fibrinogen B-soluble fibrin monomer complexes precipitable by ethanol and 2-naphthol]. Ethanol 73-80 fibrinogen beta chain Homo sapiens 11-21 7213845-0 1980 [Nature of fibrinogen B-soluble fibrin monomer complexes precipitable by ethanol and 2-naphthol]. 2-naphthol 85-95 fibrinogen beta chain Homo sapiens 11-21 7213845-1 1980 The molecular composition of fibrinogen B, which is formed after addition of 2-naphthol solution in ethanol to pathological blood plasma was studied. 2-naphthol 77-87 fibrinogen beta chain Homo sapiens 29-39 7213845-1 1980 The molecular composition of fibrinogen B, which is formed after addition of 2-naphthol solution in ethanol to pathological blood plasma was studied. Ethanol 100-107 fibrinogen beta chain Homo sapiens 29-39 7414556-0 1980 A simple technique for purification of fibrinogen from plasma by affinity chromatography on ristocetin-agarose. ristocetin-agarose 92-110 fibrinogen beta chain Homo sapiens 39-49 6767512-3 1980 Binding of 125iodine-labeled fibrinogen to human gel-filtered platelts was maximal at 1 min, and the receptors were saturated when the fibrinogen concentration in the suspending medium approached 0.8 mg/ml. Iodine-125 11-20 fibrinogen beta chain Homo sapiens 135-145 6767512-1 1980 Fibrinogen is essential for aggregating platelets with adenosine diphosphate (ADP) and was recently shown to bind to platelets stimulated with ADP. Adenosine Diphosphate 55-76 fibrinogen beta chain Homo sapiens 0-10 6767512-1 1980 Fibrinogen is essential for aggregating platelets with adenosine diphosphate (ADP) and was recently shown to bind to platelets stimulated with ADP. Adenosine Diphosphate 78-81 fibrinogen beta chain Homo sapiens 0-10 6767512-1 1980 Fibrinogen is essential for aggregating platelets with adenosine diphosphate (ADP) and was recently shown to bind to platelets stimulated with ADP. Adenosine Diphosphate 143-146 fibrinogen beta chain Homo sapiens 0-10 6767512-3 1980 Binding of 125iodine-labeled fibrinogen to human gel-filtered platelts was maximal at 1 min, and the receptors were saturated when the fibrinogen concentration in the suspending medium approached 0.8 mg/ml. Iodine-125 11-20 fibrinogen beta chain Homo sapiens 29-39 6767512-7 1980 Fibrinogen binding was also virtually absent with platelets that had been incubated with EDTA for 8 min at 37 degrees C and pH 7.8. Edetic Acid 89-93 fibrinogen beta chain Homo sapiens 0-10 6767512-9 1980 Thus, ADP-induced binding of fibrinogen correlates with platelet aggregability. Adenosine Diphosphate 6-9 fibrinogen beta chain Homo sapiens 29-39 6997706-1 1980 Plasma fibrinogen is elevated in various stressful states and conditions in which active mobilization of free fatty acids (FFA) occurs. Fatty Acids, Nonesterified 105-121 fibrinogen beta chain Homo sapiens 7-17 6997706-1 1980 Plasma fibrinogen is elevated in various stressful states and conditions in which active mobilization of free fatty acids (FFA) occurs. Fatty Acids, Nonesterified 123-126 fibrinogen beta chain Homo sapiens 7-17 6769127-1 1980 Antibodies to the disulfide knot fragment of bovine fibrinogen have been used to locate the site of this fragment within the intact fibrinogen molecule. Disulfides 18-27 fibrinogen beta chain Homo sapiens 52-62 6769127-1 1980 Antibodies to the disulfide knot fragment of bovine fibrinogen have been used to locate the site of this fragment within the intact fibrinogen molecule. Disulfides 18-27 fibrinogen beta chain Homo sapiens 132-142 6769127-3 1980 Electron micrographs of reaction mixtures of bovine fibrinogen and antibodies against the disulfide knot fragment showed pairs of fibrinogen molecules crosslinked by antibody molecules as well as higher order antibody-fibrinogen complexes. Disulfides 90-99 fibrinogen beta chain Homo sapiens 52-62 6769127-3 1980 Electron micrographs of reaction mixtures of bovine fibrinogen and antibodies against the disulfide knot fragment showed pairs of fibrinogen molecules crosslinked by antibody molecules as well as higher order antibody-fibrinogen complexes. Disulfides 90-99 fibrinogen beta chain Homo sapiens 130-140 6769127-3 1980 Electron micrographs of reaction mixtures of bovine fibrinogen and antibodies against the disulfide knot fragment showed pairs of fibrinogen molecules crosslinked by antibody molecules as well as higher order antibody-fibrinogen complexes. Disulfides 90-99 fibrinogen beta chain Homo sapiens 130-140 6769127-4 1980 From an electron microscopic investigation of the crosslinked material, we conclude that the disulfide knot lies within the central nodule of the trinodular fibrinogen molecule. Disulfides 93-102 fibrinogen beta chain Homo sapiens 157-167 7470554-0 1980 The polymerization of fibrinogen under the influence of diazomethane modification. Diazomethane 56-68 fibrinogen beta chain Homo sapiens 22-32 7470554-1 1980 To study the effect of the acidic amino acid residues on the physiological polymerization and clot formation of fibrinogen, the fibrinogen system was polymerized by interaction with diazomethane, a specific group reagent which modifies the carboxylic acid residues via the process of methylation. Diazomethane 182-194 fibrinogen beta chain Homo sapiens 112-122 7470554-1 1980 To study the effect of the acidic amino acid residues on the physiological polymerization and clot formation of fibrinogen, the fibrinogen system was polymerized by interaction with diazomethane, a specific group reagent which modifies the carboxylic acid residues via the process of methylation. Diazomethane 182-194 fibrinogen beta chain Homo sapiens 128-138 7470554-1 1980 To study the effect of the acidic amino acid residues on the physiological polymerization and clot formation of fibrinogen, the fibrinogen system was polymerized by interaction with diazomethane, a specific group reagent which modifies the carboxylic acid residues via the process of methylation. Carboxylic Acids 240-255 fibrinogen beta chain Homo sapiens 112-122 7470554-1 1980 To study the effect of the acidic amino acid residues on the physiological polymerization and clot formation of fibrinogen, the fibrinogen system was polymerized by interaction with diazomethane, a specific group reagent which modifies the carboxylic acid residues via the process of methylation. Carboxylic Acids 240-255 fibrinogen beta chain Homo sapiens 128-138 7470554-2 1980 The extent of methylation of fibrinogen by diazomethane was estimated by methoxyl determination on the modified fibrinogen. Diazomethane 43-55 fibrinogen beta chain Homo sapiens 29-39 7470554-2 1980 The extent of methylation of fibrinogen by diazomethane was estimated by methoxyl determination on the modified fibrinogen. Diazomethane 43-55 fibrinogen beta chain Homo sapiens 112-122 7470554-2 1980 The extent of methylation of fibrinogen by diazomethane was estimated by methoxyl determination on the modified fibrinogen. 7-methoxy-6-(2'-methoxy-3'-hydroxy-3'-methyl butyl) 73-81 fibrinogen beta chain Homo sapiens 29-39 7470554-2 1980 The extent of methylation of fibrinogen by diazomethane was estimated by methoxyl determination on the modified fibrinogen. 7-methoxy-6-(2'-methoxy-3'-hydroxy-3'-methyl butyl) 73-81 fibrinogen beta chain Homo sapiens 112-122 7470554-6 1980 These results are interpreted in terms of methylation of carboxylic acid groups in fibrinogen by diazomethane providing a reduction of both negative charge and intermolecular repulsion, thereby enabling the modified fibrinogen molecules to polymerize. Carboxylic Acids 57-72 fibrinogen beta chain Homo sapiens 83-93 7470554-6 1980 These results are interpreted in terms of methylation of carboxylic acid groups in fibrinogen by diazomethane providing a reduction of both negative charge and intermolecular repulsion, thereby enabling the modified fibrinogen molecules to polymerize. Carboxylic Acids 57-72 fibrinogen beta chain Homo sapiens 216-226 7470554-6 1980 These results are interpreted in terms of methylation of carboxylic acid groups in fibrinogen by diazomethane providing a reduction of both negative charge and intermolecular repulsion, thereby enabling the modified fibrinogen molecules to polymerize. Diazomethane 97-109 fibrinogen beta chain Homo sapiens 83-93 7470554-6 1980 These results are interpreted in terms of methylation of carboxylic acid groups in fibrinogen by diazomethane providing a reduction of both negative charge and intermolecular repulsion, thereby enabling the modified fibrinogen molecules to polymerize. Diazomethane 97-109 fibrinogen beta chain Homo sapiens 216-226 6769460-2 1980 Fibrinogen purified from the patient"s plasma by precipitation with beta-alanine also gave a prolonged thrombin time and this confirmed the presence of a dysfibrinogenaemia. beta-Alanine 68-80 fibrinogen beta chain Homo sapiens 0-10 7404479-0 1980 Relationship of ADP-induced fibrinogen binding to platelet shape change and aggregation elucidated by use of colchicine and cytochalasin B. Adenosine Diphosphate 16-19 fibrinogen beta chain Homo sapiens 28-38 7404479-0 1980 Relationship of ADP-induced fibrinogen binding to platelet shape change and aggregation elucidated by use of colchicine and cytochalasin B. Colchicine 109-119 fibrinogen beta chain Homo sapiens 28-38 7404479-0 1980 Relationship of ADP-induced fibrinogen binding to platelet shape change and aggregation elucidated by use of colchicine and cytochalasin B. Cytochalasin B 124-138 fibrinogen beta chain Homo sapiens 28-38 7404479-1 1980 ADP causes human, aspirin-treated, gel-filtered platelets to change from their native discoid shape to spiny spheres with pseudopods, bind 125I-labeled fibrinogen, and aggregate if shaken with sufficient fibrinogen. Adenosine Diphosphate 0-3 fibrinogen beta chain Homo sapiens 152-162 7404479-1 1980 ADP causes human, aspirin-treated, gel-filtered platelets to change from their native discoid shape to spiny spheres with pseudopods, bind 125I-labeled fibrinogen, and aggregate if shaken with sufficient fibrinogen. Adenosine Diphosphate 0-3 fibrinogen beta chain Homo sapiens 204-214 7404479-1 1980 ADP causes human, aspirin-treated, gel-filtered platelets to change from their native discoid shape to spiny spheres with pseudopods, bind 125I-labeled fibrinogen, and aggregate if shaken with sufficient fibrinogen. Aspirin 18-25 fibrinogen beta chain Homo sapiens 152-162 7404479-1 1980 ADP causes human, aspirin-treated, gel-filtered platelets to change from their native discoid shape to spiny spheres with pseudopods, bind 125I-labeled fibrinogen, and aggregate if shaken with sufficient fibrinogen. Aspirin 18-25 fibrinogen beta chain Homo sapiens 204-214 7404479-1 1980 ADP causes human, aspirin-treated, gel-filtered platelets to change from their native discoid shape to spiny spheres with pseudopods, bind 125I-labeled fibrinogen, and aggregate if shaken with sufficient fibrinogen. Iodine-125 139-143 fibrinogen beta chain Homo sapiens 152-162 7404479-2 1980 After destruction of the added ADP with the enzyme apyrase, the platelets revert to a disc shape and lose much of their bound fibrinogen. Adenosine Diphosphate 31-34 fibrinogen beta chain Homo sapiens 126-136 7404479-6 1980 Thus, these findings support earlier studies with thrombasthenic and EDTA-treated platelets and with normal platelets at low pH, or in the presence of EDTA to indicate that fibrinogen binding is associated with aggregability but not with platelet shape. Edetic Acid 69-73 fibrinogen beta chain Homo sapiens 173-183 7404479-6 1980 Thus, these findings support earlier studies with thrombasthenic and EDTA-treated platelets and with normal platelets at low pH, or in the presence of EDTA to indicate that fibrinogen binding is associated with aggregability but not with platelet shape. Edetic Acid 151-155 fibrinogen beta chain Homo sapiens 173-183 6985716-0 1980 Prostacyclin inhibits mobilisation of fibrinogen-binding sites on human ADP- and thrombin-treated platelets. Epoprostenol 0-12 fibrinogen beta chain Homo sapiens 38-48 6985716-5 1980 Intact plasma fibrinogen is required for the aggregation of platelets induced by ADP, and endogenous platelet fibrinogen influences thrombin-induced aggregation. Adenosine Diphosphate 81-84 fibrinogen beta chain Homo sapiens 14-24 6985716-6 1980 We have therefore studied the effect of prostacyclin on the interaction of fibrinogen with human platelets. Epoprostenol 40-52 fibrinogen beta chain Homo sapiens 75-85 6452172-2 1981 The previously described protective effect of calcium ions on the gamma-chain carboxy-terminals of fibrinogen against attack has been confirmed by working at high plasmin concentrations and/or in the presence of 2 M urea. Urea 216-220 fibrinogen beta chain Homo sapiens 99-109 479159-8 1979 The distribution of iodine as mono- and diiodotyrosine in N-DSK and Ho1-DSK reflected the percentage (83 and 17, respectively) found in iodinated fibrinogen from which these fragments were prepared. Iodine 20-26 fibrinogen beta chain Homo sapiens 146-156 6985716-7 1980 We now report that prostacyclin inhibits the mobilisation of specific binding sites ("receptors") for fibrinogen on human platelets and that this effect parallels the inhibition of ADP- or thrombin-induced aggregation. Epoprostenol 19-31 fibrinogen beta chain Homo sapiens 102-112 6985716-8 1980 The inhibitory effect of prostacyclin may limit the extent of platelet-fibrinogen interaction in vivo and in extracorporeal circulation. Epoprostenol 25-37 fibrinogen beta chain Homo sapiens 71-81 381698-1 1979 Nine patients treated with valproic acid had low plasma fibrinogen concentration and other liver function abnormalities. Valproic Acid 27-40 fibrinogen beta chain Homo sapiens 56-66 484913-2 1979 Reduction in plasma fibrinogen was associated with a sustained reduction in plasma and blood viscosity, and a sustained increase in nutritional skin blood flow, measured by a Xenon-133 clearance technique (P less than 0.001). Xenon 175-180 fibrinogen beta chain Homo sapiens 20-30 499635-4 1979 Patients treated with a sulphonylurea (n = 81) had the highest mean log plasma fibrinogen concentration and this was significantly higher than in patients treated with insulin (n = 76; p less than 0.01), biguanides (n = 28; p less than 0.01) or sulphonyluera plus biguanides (n = 38; p less than 0.05). Sulfonylurea Compounds 24-37 fibrinogen beta chain Homo sapiens 79-89 499635-5 1979 The biganide treated group had the lowest mean log plasma fibrinogen concentrations. biganide 4-12 fibrinogen beta chain Homo sapiens 58-68 499635-8 1979 Twenty-two maturity onset diabetics treated with a sulphonylurea and followed prospectively showed a significant increase in plasma fibrinogen after five months (p less than 0.0001), while a control diet treated group showed no alteration in plasma fibrinogen. Sulfonylurea Compounds 51-64 fibrinogen beta chain Homo sapiens 132-142 509787-2 1979 Mean fibrin deposition within the dialyzers, measured as gram X 10(-3) of clottable fibrinogen, was significantly less during sulphinpyrazone treatment (2.5) than during the control period (5.3). Sulfinpyrazone 126-141 fibrinogen beta chain Homo sapiens 84-94 509787-4 1979 The results indicate that sulphinpyrazone reduces fibrin formation within artificial kidneys and, since the reduction in deposition of fibrin alone is insufficient to explain the higher plasma fibrinogen levels during treatment with sulphinpyrazone, suggests that this therapy reduces fibrinogen consumption within the patient during hemodialysis. Sulfinpyrazone 26-41 fibrinogen beta chain Homo sapiens 193-203 509787-4 1979 The results indicate that sulphinpyrazone reduces fibrin formation within artificial kidneys and, since the reduction in deposition of fibrin alone is insufficient to explain the higher plasma fibrinogen levels during treatment with sulphinpyrazone, suggests that this therapy reduces fibrinogen consumption within the patient during hemodialysis. Sulfinpyrazone 26-41 fibrinogen beta chain Homo sapiens 285-295 509787-4 1979 The results indicate that sulphinpyrazone reduces fibrin formation within artificial kidneys and, since the reduction in deposition of fibrin alone is insufficient to explain the higher plasma fibrinogen levels during treatment with sulphinpyrazone, suggests that this therapy reduces fibrinogen consumption within the patient during hemodialysis. Sulfinpyrazone 233-248 fibrinogen beta chain Homo sapiens 193-203 509787-4 1979 The results indicate that sulphinpyrazone reduces fibrin formation within artificial kidneys and, since the reduction in deposition of fibrin alone is insufficient to explain the higher plasma fibrinogen levels during treatment with sulphinpyrazone, suggests that this therapy reduces fibrinogen consumption within the patient during hemodialysis. Sulfinpyrazone 233-248 fibrinogen beta chain Homo sapiens 285-295 574098-5 1979 However, clofibrate and combined therapy significantly decreased total and low density lipoprotein cholesterol, total and very low density lipoprotein triglyceride and fibrinogen. Clofibrate 9-19 fibrinogen beta chain Homo sapiens 168-178 542025-7 1979 By injecting 131I-human fibrinogen intravenously, we observed a small reduction in clottability (maximum of 10%) in lymph both from the RD and TD. Iodine-131 13-17 fibrinogen beta chain Homo sapiens 24-34 159511-2 1979 Agarose gel filtration of these samples revealed the presence of fibrinogen derivatives both larger and smaller than the parent molecule. Sepharose 0-7 fibrinogen beta chain Homo sapiens 65-75 505375-4 1979 polyacrylamide gel and had a molecular weight similar to the A alpha-chain of human fibrinogen. polyacrylamide 0-14 fibrinogen beta chain Homo sapiens 84-94 505378-3 1979 The sedimentation rate of washed human red cells suspended in saline, was found to be directly proportional to the concentration of added purified human fibrinogen, down to 250 mg%, below which there was no difference from saline controls. Sodium Chloride 62-68 fibrinogen beta chain Homo sapiens 153-163 111639-7 1979 Pretreatment with heparin prevents the consumption of fibrinogen and antithrombin III but does not prevent the increase in fibrin split products which was observed. Heparin 18-25 fibrinogen beta chain Homo sapiens 54-64 478136-0 1979 Purification of fibrinogen and the separation of its degradation products in the presence of calcium ions [proceedings]. Calcium 93-100 fibrinogen beta chain Homo sapiens 16-26 228684-16 1979 The plasma fibrinogen levels and the erythrocyte sedimentation rates were reduced during treatment with both niceritrol and clofibrate. Niceritrol 109-119 fibrinogen beta chain Homo sapiens 11-21 478137-0 1979 Cross-linking of fibrinogen with dimethyl suberimidate [proceedings]. Dimethyl Suberimidate 33-54 fibrinogen beta chain Homo sapiens 17-27 228684-16 1979 The plasma fibrinogen levels and the erythrocyte sedimentation rates were reduced during treatment with both niceritrol and clofibrate. Clofibrate 124-134 fibrinogen beta chain Homo sapiens 11-21 158526-2 1979 The cyanogen bromide fragment, N-DSK, containing the NH2-terminal portions of the three chains of fibrinogen, was found to exist in dimeric and polymeric forms. Cyanogen Bromide 4-20 fibrinogen beta chain Homo sapiens 98-108 465525-0 1979 The binding of calcium to fibrinogen: influence on the clotting process. Calcium 15-22 fibrinogen beta chain Homo sapiens 26-36 462354-6 1979 The fall in fibrinogen was so low in some patients that the routine administration of a conventional dosage of heparin could be dangerous. Heparin 111-118 fibrinogen beta chain Homo sapiens 12-22 313396-4 1979 The amount of grafted protein, determined by the ninhydrin method, reveals that, at least, plasma proteins such as serum albumin and fibrinogen are grafted to the film surface in a monomolecular layer without undergoing a marked denaturation. Ninhydrin 49-58 fibrinogen beta chain Homo sapiens 133-143 157166-0 1979 On the specific interaction between the lysine-binding sites in plasmin and complementary sites in alpha2-antiplasmin and in fibrinogen. Lysine 40-46 fibrinogen beta chain Homo sapiens 125-135 157166-5 1979 Fibrinogen, fibrinogen digested with plasmin, purified fragment E and purified fragment D interfere with the reaction between plasmin and alpha2-antiplasmin by competing with alpha2-antiplasmin for the lysine-binding site(s) in the plasmin A-chain. Lysine 202-208 fibrinogen beta chain Homo sapiens 0-10 157166-5 1979 Fibrinogen, fibrinogen digested with plasmin, purified fragment E and purified fragment D interfere with the reaction between plasmin and alpha2-antiplasmin by competing with alpha2-antiplasmin for the lysine-binding site(s) in the plasmin A-chain. Lysine 202-208 fibrinogen beta chain Homo sapiens 12-22 157166-7 1979 Thus the fibrinogen molecule contains several complementary sites to the lysine-binding sites located both in its NH2-terminal and COOH-terminal regions; these sites are to a large extent. Lysine 73-79 fibrinogen beta chain Homo sapiens 9-19 444675-4 1979 Fibrinogen depleted of fibronectin (less than 2 microgram/mg) supported ADP-induced aggregation as effectively as fibrinogen contaminated with this protein, thus reinforcing the generally held view that fibrinogen itself is the necessary protein cofactor in this reaction. Adenosine Diphosphate 72-75 fibrinogen beta chain Homo sapiens 0-10 444675-4 1979 Fibrinogen depleted of fibronectin (less than 2 microgram/mg) supported ADP-induced aggregation as effectively as fibrinogen contaminated with this protein, thus reinforcing the generally held view that fibrinogen itself is the necessary protein cofactor in this reaction. Adenosine Diphosphate 72-75 fibrinogen beta chain Homo sapiens 203-213 30781910-2 1979 The gel-chromatography of the beta-alanine precipitate of human plasma and of purified fibrinogen shows the presence of different classes of fibrinogen complexes. beta-Alanine 30-42 fibrinogen beta chain Homo sapiens 141-151 483243-3 1979 Furthermore, even in the absence of activated factor XIII, fibrinogen and fibrin incorporated cinnamic acid. cinnamic acid 94-107 fibrinogen beta chain Homo sapiens 59-69 380614-8 1979 In all patients, clofibrate therapy was associated with a significant 19-23% reduction in plasma fibrinogen. Clofibrate 17-27 fibrinogen beta chain Homo sapiens 97-107 483243-4 1979 Thus, as well as reacting with the functional thiol group of factor XIII, the thiocholine ester of cinnamic acid is incorporated non-specifically throughout the fibrinogen and fibrin subunit chains. thiocholine ester 78-95 fibrinogen beta chain Homo sapiens 161-171 483243-4 1979 Thus, as well as reacting with the functional thiol group of factor XIII, the thiocholine ester of cinnamic acid is incorporated non-specifically throughout the fibrinogen and fibrin subunit chains. cinnamic acid 99-112 fibrinogen beta chain Homo sapiens 161-171 572134-6 1979 The turbidimetric ammonium sulfate and sodium sulfite precipitation methods correlated less well with the reference method, and in particular, the sodium sulfite technic gave high apparent fibrinogen levels with jaundiced plasmas. sodium sulfite 147-161 fibrinogen beta chain Homo sapiens 189-199 223026-7 1979 Fibrinogen on IgA myeloma protein increases the lactate production, but not the oxygen consumption. Lactic Acid 48-55 fibrinogen beta chain Homo sapiens 0-10 468466-5 1979 An application of the method is demonstrated by measuring the increase in amino-terminal glycine in fibrinogen following the proteolytic action of thrombin. Glycine 89-96 fibrinogen beta chain Homo sapiens 100-110 473117-4 1979 PMMA sequence of the copolymer played the leading role in fibrinogen, immunoglobulins, transferrin and albumin adsorption. Polymethyl Methacrylate 0-4 fibrinogen beta chain Homo sapiens 58-68 473117-4 1979 PMMA sequence of the copolymer played the leading role in fibrinogen, immunoglobulins, transferrin and albumin adsorption. copolymer 21-30 fibrinogen beta chain Homo sapiens 58-68 473117-5 1979 These proteins adsorbed on the copolymer, showed different competitive desorption pattern in the presence of whole plasma: fibrinogen presented the highest degree of affinity for the copolymer. copolymer 31-40 fibrinogen beta chain Homo sapiens 123-133 473117-5 1979 These proteins adsorbed on the copolymer, showed different competitive desorption pattern in the presence of whole plasma: fibrinogen presented the highest degree of affinity for the copolymer. copolymer 183-192 fibrinogen beta chain Homo sapiens 123-133 162473-5 1979 Results in diabetics after surgery, etc., will also be presented, and (3) in a prospective study of newly-diagnosed, mostly maturity-onset type diabetics, an increase in plasma fibrinogen (thrombin coagulation of plasma, controlled against normals) was observed during the first 3 yr, largely due to males treated with sulfonylureas; decreases in platelet count and in prothrombin concentration were also statistically significant. Sulfonylurea Compounds 319-332 fibrinogen beta chain Homo sapiens 177-187 472639-4 1979 Blood fibrinogen concentrations were significantly lowered by clofibrate therapy and only slightly influenced by Na isobutyrate. Clofibrate 62-72 fibrinogen beta chain Homo sapiens 6-16 429103-0 1979 H and 13C nuclear magnetic resonance spectra of some peptides with fibrinogen-like reactivity. 13c 6-9 fibrinogen beta chain Homo sapiens 67-77 429103-4 1979 It is proposed that this feature (in which Phe could be situated near Val and near the Arg-Gly bond of the A alpha chain in the three-dimensional structure of fibrinogen) may be especially advantageous for binding to the enzyme. Phenylalanine 43-46 fibrinogen beta chain Homo sapiens 159-169 429103-4 1979 It is proposed that this feature (in which Phe could be situated near Val and near the Arg-Gly bond of the A alpha chain in the three-dimensional structure of fibrinogen) may be especially advantageous for binding to the enzyme. Valine 70-73 fibrinogen beta chain Homo sapiens 159-169 429103-4 1979 It is proposed that this feature (in which Phe could be situated near Val and near the Arg-Gly bond of the A alpha chain in the three-dimensional structure of fibrinogen) may be especially advantageous for binding to the enzyme. Arginine 87-90 fibrinogen beta chain Homo sapiens 159-169 429103-4 1979 It is proposed that this feature (in which Phe could be situated near Val and near the Arg-Gly bond of the A alpha chain in the three-dimensional structure of fibrinogen) may be especially advantageous for binding to the enzyme. Glycine 91-94 fibrinogen beta chain Homo sapiens 159-169 421898-0 1979 Calcium-binding properties of human fibrin(ogen) and degradation products. Calcium 0-7 fibrinogen beta chain Homo sapiens 36-48 429567-8 1979 Fibrinogen survival gave a better correlation with serial glucose measurements than with correction of hemoglobin A(Ic) levels indicating that the reduced fibrinogen survival noted in diabetics is a rapidly reversible phenomenon. Glucose 58-65 fibrinogen beta chain Homo sapiens 0-10 429567-8 1979 Fibrinogen survival gave a better correlation with serial glucose measurements than with correction of hemoglobin A(Ic) levels indicating that the reduced fibrinogen survival noted in diabetics is a rapidly reversible phenomenon. Glucose 58-65 fibrinogen beta chain Homo sapiens 155-165 429567-11 1979 Heparin infusion during hyperglycemia normalized the fibrinogen kinetics of hyperglycemic diabetic patients, suggesting that reduced fibrinogen survival during hyperglycemia is secondary to an effect on thrombin or one of its antagonists. Heparin 0-7 fibrinogen beta chain Homo sapiens 53-63 429567-11 1979 Heparin infusion during hyperglycemia normalized the fibrinogen kinetics of hyperglycemic diabetic patients, suggesting that reduced fibrinogen survival during hyperglycemia is secondary to an effect on thrombin or one of its antagonists. Heparin 0-7 fibrinogen beta chain Homo sapiens 133-143 420779-1 1979 The beta chain of human fibrinogen contains 461 amino acid residues, 15 of which are methionines. Methionine 85-96 fibrinogen beta chain Homo sapiens 24-34 420998-10 1979 Plasma fibrinogen concentrations increase with age and obesity, are higher in smokers than non-smokers, and fall with alcohol consumption. Alcohols 118-125 fibrinogen beta chain Homo sapiens 7-17 420779-5 1979 The arrangement of the cyanogen bromide peptides was deduced by the use of overlap fragments obtained from the tryptic digestion of modified and unmodified beta-chains and from digestions with staphylococcal protease, as well as by considerations involving the plasmic digestion products of fibrinogen. Cyanogen Bromide 23-39 fibrinogen beta chain Homo sapiens 291-301 433647-2 1979 A post-phlebographic accumulation of 125I-fibrinogen was found in 6 patients examined with meglumine-metrizoate indicating a post-phlebographic thrombosis. methylglucamine metrizoate 91-111 fibrinogen beta chain Homo sapiens 42-52 549504-0 1979 Effect of air nuclei on the adsorption of fibrinogen to silicone rubber. Silicones 56-64 fibrinogen beta chain Homo sapiens 42-52 738701-0 1978 Disulfide bridges in the middle part of human fibrinogen. Disulfides 0-9 fibrinogen beta chain Homo sapiens 46-56 89992-1 1979 Examinations performed by means of the agargel-electrophoresis, immunoelectrophoresis, discelectrophoresis, and chromatography on gel in human plasma and preparations of fibrinogen revealed that fibrinogen will form complexes with 18 examined dyes of different chemical structure, from a total amounting to 46. agargel 39-46 fibrinogen beta chain Homo sapiens 195-205 422251-7 1979 These rather poor results are not surprising if one considers that NBT is only taken up by granulocytes as macrocomplex containing heparin or fibrinogen. Nitroblue Tetrazolium 67-70 fibrinogen beta chain Homo sapiens 142-152 738701-1 1978 Human fibrinogen contains 29 disulfide bridges per molecule. Disulfides 29-38 fibrinogen beta chain Homo sapiens 6-16 738701-3 1978 When fibrinogen is cleaved by cyanogen bromide five disulfide-containing fragments are formed. Cyanogen Bromide 30-46 fibrinogen beta chain Homo sapiens 5-15 738701-3 1978 When fibrinogen is cleaved by cyanogen bromide five disulfide-containing fragments are formed. Disulfides 52-61 fibrinogen beta chain Homo sapiens 5-15 713434-0 1978 [The influence of tinofedrine on fibrinogen and platelet aggregation in patients with recent cerebral infarction (author"s transl)]. tinofedrine 18-29 fibrinogen beta chain Homo sapiens 33-43 730118-1 1978 Preliminary note on a disulfide-containing internal peptide of the alpha-chain, obtained by plasmic digestion of fibrinogen. Disulfides 22-31 fibrinogen beta chain Homo sapiens 113-123 738797-0 1978 The effect of radiolabeling of human fibrinogen on its adsorption behaviour on a polystyrene surface. Polystyrenes 81-92 fibrinogen beta chain Homo sapiens 37-47 738797-1 1978 Human fibrinogen (HFB) was labeled with different radioactive labels (Technetium -99m and iodine -125) in various ways. Technetium 70-80 fibrinogen beta chain Homo sapiens 6-16 738797-1 1978 Human fibrinogen (HFB) was labeled with different radioactive labels (Technetium -99m and iodine -125) in various ways. Iodine 90-96 fibrinogen beta chain Homo sapiens 6-16 748725-0 1978 The relationship between cutaneous blood flow and rate of incorporation of 125I-labelled fibrinogen into a cutaneous vein thrombus. Iodine-125 75-79 fibrinogen beta chain Homo sapiens 89-99 104402-3 1978 It was confirmed that during pregnancy there is an elevation of the fibrinogen degradation products (FDP) levels with a proportional increase in the numbers of positive protamine sulfate and ethanol tests. Ethanol 191-198 fibrinogen beta chain Homo sapiens 68-78 104402-4 1978 The proportion of positive protamine sulfate and ethanol tests reaches a maximum in the expulsion of the placenta coinciding with the presence of soluble complexes heavier than fibrinogen as detected by polyacrylamide gel electrophoresis and by column chromatography. Ethanol 49-56 fibrinogen beta chain Homo sapiens 177-187 104402-4 1978 The proportion of positive protamine sulfate and ethanol tests reaches a maximum in the expulsion of the placenta coinciding with the presence of soluble complexes heavier than fibrinogen as detected by polyacrylamide gel electrophoresis and by column chromatography. polyacrylamide 203-217 fibrinogen beta chain Homo sapiens 177-187 722804-3 1978 The section of kappa-casein which contains the chymosin-sensitive bond has a counterpart not only in the gamma but also in the Bbeta-chain of fibrinogen. bbeta 127-132 fibrinogen beta chain Homo sapiens 142-152 707435-1 1978 The ristocetin precipitation test was designed as a simplified test to detect fibrin monomers and fibrinogen/fibrin degradation products (FPD/fdp). Ristocetin 4-14 fibrinogen beta chain Homo sapiens 98-108 687825-2 1978 With this technique the effect of calcium on the three distinguishable phases of clot formation, (1) proteolysis of fibrinogen, (2) fibrinogen-fibrin monomer complex formation, and (3) fibrin monomer polymerization, were investigated. Calcium 34-41 fibrinogen beta chain Homo sapiens 116-126 687825-2 1978 With this technique the effect of calcium on the three distinguishable phases of clot formation, (1) proteolysis of fibrinogen, (2) fibrinogen-fibrin monomer complex formation, and (3) fibrin monomer polymerization, were investigated. Calcium 34-41 fibrinogen beta chain Homo sapiens 132-142 687825-5 1978 These data show that calcium decreases the time required for fibrin formation from fibrinogen by markedly accelerating the phase of fibrin monomer polymerization. Calcium 21-28 fibrinogen beta chain Homo sapiens 83-93 746526-0 1978 Interaction of fibrinogen with fluorescein isothiocyanate. Fluorescein-5-isothiocyanate 31-57 fibrinogen beta chain Homo sapiens 15-25 101250-0 1978 Functional consequences of tryptophan modification in human fibrinogen. Tryptophan 27-37 fibrinogen beta chain Homo sapiens 60-70 101250-1 1978 When human fibrinogen was modified with H2O2, inter- and intra-molecular cross-links of fibrinogen were formed, accompanied with oxidation of tryptophan, methionine and tyrosine residues. Hydrogen Peroxide 40-44 fibrinogen beta chain Homo sapiens 11-21 101250-1 1978 When human fibrinogen was modified with H2O2, inter- and intra-molecular cross-links of fibrinogen were formed, accompanied with oxidation of tryptophan, methionine and tyrosine residues. Hydrogen Peroxide 40-44 fibrinogen beta chain Homo sapiens 88-98 101250-1 1978 When human fibrinogen was modified with H2O2, inter- and intra-molecular cross-links of fibrinogen were formed, accompanied with oxidation of tryptophan, methionine and tyrosine residues. Tryptophan 142-152 fibrinogen beta chain Homo sapiens 11-21 101250-1 1978 When human fibrinogen was modified with H2O2, inter- and intra-molecular cross-links of fibrinogen were formed, accompanied with oxidation of tryptophan, methionine and tyrosine residues. Tryptophan 142-152 fibrinogen beta chain Homo sapiens 88-98 101250-1 1978 When human fibrinogen was modified with H2O2, inter- and intra-molecular cross-links of fibrinogen were formed, accompanied with oxidation of tryptophan, methionine and tyrosine residues. Methionine 154-164 fibrinogen beta chain Homo sapiens 11-21 101250-1 1978 When human fibrinogen was modified with H2O2, inter- and intra-molecular cross-links of fibrinogen were formed, accompanied with oxidation of tryptophan, methionine and tyrosine residues. Methionine 154-164 fibrinogen beta chain Homo sapiens 88-98 101250-1 1978 When human fibrinogen was modified with H2O2, inter- and intra-molecular cross-links of fibrinogen were formed, accompanied with oxidation of tryptophan, methionine and tyrosine residues. Tyrosine 169-177 fibrinogen beta chain Homo sapiens 11-21 101250-1 1978 When human fibrinogen was modified with H2O2, inter- and intra-molecular cross-links of fibrinogen were formed, accompanied with oxidation of tryptophan, methionine and tyrosine residues. Tyrosine 169-177 fibrinogen beta chain Homo sapiens 88-98 101250-4 1978 Modification of tryptophan residues in fibrinogen was also performed with 2-hydroxy-5-nitrobenzyl bromide. Tryptophan 16-26 fibrinogen beta chain Homo sapiens 39-49 101250-4 1978 Modification of tryptophan residues in fibrinogen was also performed with 2-hydroxy-5-nitrobenzyl bromide. 2-Hydroxy-5-nitrobenzyl Bromide 74-105 fibrinogen beta chain Homo sapiens 39-49 702523-9 1978 Addition of a crude preparation of fibrinogen in physiological amounts to isotonic saline and human serum albumin restores the cell water lifetime to a value similar to that observed in plasma. Sodium Chloride 83-89 fibrinogen beta chain Homo sapiens 35-45 702523-9 1978 Addition of a crude preparation of fibrinogen in physiological amounts to isotonic saline and human serum albumin restores the cell water lifetime to a value similar to that observed in plasma. Water 132-137 fibrinogen beta chain Homo sapiens 35-45 98988-0 1978 131I-labeled fibrinogen in the diagnosis of deep vein thrombosis of the lower extremities. Iodine-131 0-4 fibrinogen beta chain Homo sapiens 13-23 98988-1 1978 Autologous 131I-labeled fibrinogen was administered to 17 patients during 19 episodes of suspected lower extremity deep vein thrombosis in an attempt to assess its diagnostic accuracy. Iodine-131 11-15 fibrinogen beta chain Homo sapiens 24-34 711985-0 1978 [Complex formation reaction between heparin and fibrinogen in normal subjects and in disease]. Heparin 36-43 fibrinogen beta chain Homo sapiens 48-58 681830-5 1978 The surface saturation concentration (ng/cm2) for albumin, fibrinogen, or IgG were all found to be more on PVC (a hydrophobic surface) than on Cuprophane (a hydrophilic surface). cuprammonium cellulose 143-153 fibrinogen beta chain Homo sapiens 59-69 681999-1 1978 By the use of 125I-labeled fibrinogen test, the incidence of postoperative deep vein thrombosis (DVT) and the effectiveness of prophylactic low-dose heparin treatment were investigated in 110 patients who underwent elective neurosurgical procedures. Iodine-125 14-18 fibrinogen beta chain Homo sapiens 27-37 279911-2 1978 Fibrinogen modulates both Ca2+-dependent steps in the complex process of zymogen activation, involving the heterologous dissociation of subunits of the thrombin-modified zymogen (Factor XIII") species : formula: (see text) and the unmasking of iodoacetamide titratable sites during generation of transamidating activity : formula: (see text). Iodoacetamide 244-257 fibrinogen beta chain Homo sapiens 0-10 160095-0 1979 The ability of fibrinogen fragments to support ADP-induced platelet aggregation. Adenosine Diphosphate 47-50 fibrinogen beta chain Homo sapiens 15-25 673830-7 1978 Thus, in the polysulphate group, heparin has the highest affinity for antithrombin III, liquoid for fibrinogen and dextran sulphate for beta 2-glycoprotein I. polysulphate 13-25 fibrinogen beta chain Homo sapiens 100-110 673830-7 1978 Thus, in the polysulphate group, heparin has the highest affinity for antithrombin III, liquoid for fibrinogen and dextran sulphate for beta 2-glycoprotein I. Heparin 33-40 fibrinogen beta chain Homo sapiens 100-110 637713-1 1978 Eighty-six patients undergoing elective splenectomy have been investigated preoperatively and postoperatively by serial platelet counts and leg scanning using iodine 125-labeled fibrinogen. Iodine-125 159-169 fibrinogen beta chain Homo sapiens 178-188 646831-4 1978 The mean fibrinogen half-life of 8 patients given intravenous heparin increased to within one standard deviation of normal, a finding that suggested that the fibrinogen molecule in these patients was capable of normal survival. Heparin 62-69 fibrinogen beta chain Homo sapiens 9-19 646831-4 1978 The mean fibrinogen half-life of 8 patients given intravenous heparin increased to within one standard deviation of normal, a finding that suggested that the fibrinogen molecule in these patients was capable of normal survival. Heparin 62-69 fibrinogen beta chain Homo sapiens 158-168 148750-0 1978 Stabilization of the plasmin digestion products of fibrinogen and fibrin by calcium ions. Calcium 76-83 fibrinogen beta chain Homo sapiens 51-61 479159-1 1979 A study of those tyrosines in fibrinogen which are surface-oriented and which may be involved in polymerization has been investigated using as a probe iodination catalyzed by lactoperoxidase. Tyrosine 17-26 fibrinogen beta chain Homo sapiens 30-40 741431-0 1978 Calcium binding to human fibrinogen - localization of two calcium specific sites. Calcium 0-7 fibrinogen beta chain Homo sapiens 25-35 741431-0 1978 Calcium binding to human fibrinogen - localization of two calcium specific sites. Calcium 58-65 fibrinogen beta chain Homo sapiens 25-35 741445-0 1978 The arrangement of disulfide bonds in fragment D from human fibrinogen. Disulfides 19-28 fibrinogen beta chain Homo sapiens 60-70 706495-3 1978 Finding concerning the interaction of the platelets with fibrinogen connected to sepharose plead for the fact that a change of conformation in the molecule of fibrinogen precedes the specific platelet reaction. Sepharose 81-90 fibrinogen beta chain Homo sapiens 57-67 706495-3 1978 Finding concerning the interaction of the platelets with fibrinogen connected to sepharose plead for the fact that a change of conformation in the molecule of fibrinogen precedes the specific platelet reaction. Sepharose 81-90 fibrinogen beta chain Homo sapiens 159-169 364763-5 1978 ICI 55,897, an analogue of clofibrate, also normalized the HTCT and the fibrinogen and had no adverse effect on the anti-thrombin levels. Clofibrate 27-37 fibrinogen beta chain Homo sapiens 72-82 207986-6 1978 The carbohydrate content of the abnormal fibrinogen was increased, and this change was related to the abnormal fibrinogen function. Carbohydrates 4-16 fibrinogen beta chain Homo sapiens 41-51 207986-6 1978 The carbohydrate content of the abnormal fibrinogen was increased, and this change was related to the abnormal fibrinogen function. Carbohydrates 4-16 fibrinogen beta chain Homo sapiens 111-121 207986-7 1978 Enzymatic cleavage of sialic acid from the abnormal fibrinogen restored fibrinogen function to normal. N-Acetylneuraminic Acid 22-33 fibrinogen beta chain Homo sapiens 52-62 207986-7 1978 Enzymatic cleavage of sialic acid from the abnormal fibrinogen restored fibrinogen function to normal. N-Acetylneuraminic Acid 22-33 fibrinogen beta chain Homo sapiens 72-82 27377-0 1978 Interaction of an alkali stable polysaccharide from cell surface of Staphylococci with human fibrinogen. Polysaccharides 32-46 fibrinogen beta chain Homo sapiens 93-103 277910-4 1978 The peptide glycyl-L-prolyl-L-arginyl-L-proline binds to fibrinogen and to fragment D, in both cases with an association constant of approximately 5 x 10(4); it does not bind to fragment E. The number of binding sites is two for fibrinogen and one for fragment D. The tripeptide glycyl-L-prolyl-L-arginine binds less tightly and is less than half as effective in preventing polymerization. glycyl-l-prolyl-l-arginyl-l-proline 12-47 fibrinogen beta chain Homo sapiens 57-67 277910-4 1978 The peptide glycyl-L-prolyl-L-arginyl-L-proline binds to fibrinogen and to fragment D, in both cases with an association constant of approximately 5 x 10(4); it does not bind to fragment E. The number of binding sites is two for fibrinogen and one for fragment D. The tripeptide glycyl-L-prolyl-L-arginine binds less tightly and is less than half as effective in preventing polymerization. glycyl-l-prolyl-l-arginyl-l-proline 12-47 fibrinogen beta chain Homo sapiens 229-239 277910-8 1978 The last-named corresponds to the serine/arginine amino acid replacement previously reported for a defective human fibrinogen. Serine 34-40 fibrinogen beta chain Homo sapiens 115-125 277910-8 1978 The last-named corresponds to the serine/arginine amino acid replacement previously reported for a defective human fibrinogen. arginine amino acid 41-60 fibrinogen beta chain Homo sapiens 115-125 150669-2 1978 The activity of the formed enzyme was determined quantitatively from the splitting of protamin sulphate, fibrin and fibrinogen. protamin sulphate 86-103 fibrinogen beta chain Homo sapiens 116-126 685250-0 1978 [Determination of the sterol content in fibrinogen as a method of diagnosing the progression of arteriosclerosis]. Sterols 22-28 fibrinogen beta chain Homo sapiens 40-50 705685-1 1978 High molecular weight fibrinogen derivatives were precipitated from 3 ml of plasma by 0.88 M ammonium sulphate. Ammonium Sulfate 93-110 fibrinogen beta chain Homo sapiens 22-32 78084-0 1978 Fibrinogen depletion with sodium valproate. Valproic Acid 26-42 fibrinogen beta chain Homo sapiens 0-10 291382-18 1978 Amino termini of the fibrinogen moiety of cryofibrinogen were found to consist of alanine, tyrosine, and a small quantity of aspartic acid, consistent with the NH2 terminal moiety composition of normal fibrinogen but not of soluble fibrin monomer complex. Alanine 82-89 fibrinogen beta chain Homo sapiens 21-31 291382-18 1978 Amino termini of the fibrinogen moiety of cryofibrinogen were found to consist of alanine, tyrosine, and a small quantity of aspartic acid, consistent with the NH2 terminal moiety composition of normal fibrinogen but not of soluble fibrin monomer complex. Tyrosine 91-99 fibrinogen beta chain Homo sapiens 21-31 291382-18 1978 Amino termini of the fibrinogen moiety of cryofibrinogen were found to consist of alanine, tyrosine, and a small quantity of aspartic acid, consistent with the NH2 terminal moiety composition of normal fibrinogen but not of soluble fibrin monomer complex. lysyl aspartic acid 125-138 fibrinogen beta chain Homo sapiens 21-31 291382-18 1978 Amino termini of the fibrinogen moiety of cryofibrinogen were found to consist of alanine, tyrosine, and a small quantity of aspartic acid, consistent with the NH2 terminal moiety composition of normal fibrinogen but not of soluble fibrin monomer complex. Ammonia 160-163 fibrinogen beta chain Homo sapiens 21-31 665769-6 1978 The major findings were: i) the 15N enrichment of the tissue-free amino acids in malignant tissue was greater than and proportional to that in the corresponding normal tissue (P less than 0.02); ii) tumor protein synthesis rates were greater and proportional to the corresponding intestinal tissue rates (P less than 0.05); iii) the fibrinogen synthesis rate was greater than the liver protein synthesis rate (P less than 0.01), but there was no correlation between them. 15n 32-35 fibrinogen beta chain Homo sapiens 333-343 79230-1 1978 An assay of human antiplasmins has been developed utilizing radial diffusion of plasma from wells cut in plasmin-enriched, fibrinogen-agarose plates. Sepharose 134-141 fibrinogen beta chain Homo sapiens 123-133 638885-3 1978 Exercise on a treadmill induced similar changes in both groups, but during the use of Demulen the levels of fibrinogen and plasminogen were higher, antithrombin level was lower, and the recalcified clotting and dilute whole blood lysis times were shorter in group 2 than in the corresponding samples obtained from the nonpill users. SC-11800 EE 86-93 fibrinogen beta chain Homo sapiens 108-118 750207-1 1978 A new method allowing the labelling of fibrinogen with 99mTcO4- is described. Sodium Pertechnetate Tc 99m 55-62 fibrinogen beta chain Homo sapiens 39-49 750207-5 1978 The labeling yield varied from 91.68% plus or minus 6.05% to 95.18% plus or minus 2.13% according to the method of control used: the precipitation of fibrinogen by (NH4)2SO4 25% or thin-layer chromatography with methylethylketone as solvent. Ammonium Sulfate 164-173 fibrinogen beta chain Homo sapiens 150-160 273904-1 1978 The beta chain of human fibrinogen is composed of 452 +/- 5 amino acid residues, 14 of which are methionines. Methionine 97-108 fibrinogen beta chain Homo sapiens 24-34 273904-4 1978 Most of the other cyanogen bromide fragments can be aligned by homology with the alpha and/or gamma chains from human fibrinogen, although the positioning of a few of the smallest peptides is still ambiguous. Cyanogen Bromide 18-34 fibrinogen beta chain Homo sapiens 118-128 638197-0 1978 Four states of tyrosine residues in the fibrinogen molecule. Tyrosine 15-23 fibrinogen beta chain Homo sapiens 40-50 638197-1 1978 The ionization of tyrosine residues in fibrinogen was studied by a spectrophotometric method. Tyrosine 18-26 fibrinogen beta chain Homo sapiens 39-49 638197-2 1978 The total of 100 tyrosine residues in the fibrinogen molecule was classified into four states: (1) 28 tyrosine residues with pK 10.1 (m = 1.0). Tyrosine 17-25 fibrinogen beta chain Homo sapiens 42-52 638197-2 1978 The total of 100 tyrosine residues in the fibrinogen molecule was classified into four states: (1) 28 tyrosine residues with pK 10.1 (m = 1.0). Tyrosine 102-110 fibrinogen beta chain Homo sapiens 42-52 638197-4 1978 When fibrinogen was treated with 4 M guanidine . Guanidine 37-46 fibrinogen beta chain Homo sapiens 5-15 638197-6 1978 The ionization characteristics of tyrosine residues in plasmin-digested fibrinogen were similar to those of fibrinogen, while in CNBr-treated fibrinogen they were fairly different. Tyrosine 34-42 fibrinogen beta chain Homo sapiens 72-82 638954-1 1978 Fibrinogen half-life was determined in 30 patients with active or inactive malignancies by monitoring survival of administered 125I-labeled autologous fibrinogen. Iodine-125 127-131 fibrinogen beta chain Homo sapiens 0-10 638954-1 1978 Fibrinogen half-life was determined in 30 patients with active or inactive malignancies by monitoring survival of administered 125I-labeled autologous fibrinogen. Iodine-125 127-131 fibrinogen beta chain Homo sapiens 151-161 77274-4 1978 Fibrinogen is shown to form substantial coherent films on isooctane and methylene iodide, suggesting considerable unfolding and lateral association. 2,2,4-trimethylpentane 58-67 fibrinogen beta chain Homo sapiens 0-10 77274-4 1978 Fibrinogen is shown to form substantial coherent films on isooctane and methylene iodide, suggesting considerable unfolding and lateral association. methylene iodide 72-88 fibrinogen beta chain Homo sapiens 0-10 624734-0 1978 Separation of both the Bbeta- and the gamma-polypeptide chains of human fibrinogen into two main types which differ in sialic acid content. N-Acetylneuraminic Acid 119-130 fibrinogen beta chain Homo sapiens 72-82 624734-1 1978 The gamma- and Bbeta-polypeptide chains of purified human fibrinogen have each been resolved into two major species: gammaL and gammaR and BbetaL and BbetaR. bbetal 139-145 fibrinogen beta chain Homo sapiens 58-68 624734-8 1978 A larger ratio of L/R in the gamma and Bbeta chains of dysfibrinogenemia fibrinogen "Zurich II" than in those of normal fibrinogen explains the higher content of sialic acid measured in the native Zurich II fibrinogen molecule. N-Acetylneuraminic Acid 162-173 fibrinogen beta chain Homo sapiens 58-68 624734-8 1978 A larger ratio of L/R in the gamma and Bbeta chains of dysfibrinogenemia fibrinogen "Zurich II" than in those of normal fibrinogen explains the higher content of sialic acid measured in the native Zurich II fibrinogen molecule. N-Acetylneuraminic Acid 162-173 fibrinogen beta chain Homo sapiens 73-83 624734-8 1978 A larger ratio of L/R in the gamma and Bbeta chains of dysfibrinogenemia fibrinogen "Zurich II" than in those of normal fibrinogen explains the higher content of sialic acid measured in the native Zurich II fibrinogen molecule. N-Acetylneuraminic Acid 162-173 fibrinogen beta chain Homo sapiens 73-83 620051-0 1978 Photooxidation of fibrinogen in the presence of methylene blue and its effect on polymerization. Methylene Blue 48-62 fibrinogen beta chain Homo sapiens 18-28 74666-2 1978 Immediately after 1 mCi 123I-labelled fibrinogen had been given intravenously, the cervical region was examined with a gamma camera and again after 4 h and 20 h. In the control case there was little difference in activity between the left and right carotid regions. Iodine-123 24-28 fibrinogen beta chain Homo sapiens 38-48 620051-1 1978 Human fibrinogen was illuminated in the presence of methylene blue. Methylene Blue 52-66 fibrinogen beta chain Homo sapiens 6-16 620051-4 1978 It was shown that illumination of photooxidized fibrinogen and photooxidized fragment N-DSK caused the modification of histidine residues. Histidine 119-128 fibrinogen beta chain Homo sapiens 48-58 620051-9 1978 Photooxidized fibrinogen has affinity for thrombin-activated fibrinogen-Sepharose and thrombin-activated fragment N-DSK-Sepharose. Sepharose 72-81 fibrinogen beta chain Homo sapiens 14-24 620051-9 1978 Photooxidized fibrinogen has affinity for thrombin-activated fibrinogen-Sepharose and thrombin-activated fragment N-DSK-Sepharose. Sepharose 72-81 fibrinogen beta chain Homo sapiens 61-71 620051-9 1978 Photooxidized fibrinogen has affinity for thrombin-activated fibrinogen-Sepharose and thrombin-activated fragment N-DSK-Sepharose. Sepharose 120-129 fibrinogen beta chain Homo sapiens 14-24 620051-10 1978 When the former conjugate is illuminated in the presence of methylene blue its affinity for fibrinogen is decreased. Methylene Blue 60-74 fibrinogen beta chain Homo sapiens 92-102 645687-7 1978 Fibrinogen was more commonly seen in patients with CG (5/5 cases) than in those with CAG (3/11 cases). cg 51-53 fibrinogen beta chain Homo sapiens 0-10 147811-1 1978 The incubation of human fibrinogen with plasmin gives rise to an early degradation product with a molecular weight of 63,000, calculated by polyacrylamide-gel electrophoresis sodium dodecyl sulfate (PAGE-SDS); this product is resistant to the action of the plasmin for short incubation times and represents 1 +/- 0.2% of the original quantity of fibrinogen. polyacrylamide 140-154 fibrinogen beta chain Homo sapiens 24-34 147811-1 1978 The incubation of human fibrinogen with plasmin gives rise to an early degradation product with a molecular weight of 63,000, calculated by polyacrylamide-gel electrophoresis sodium dodecyl sulfate (PAGE-SDS); this product is resistant to the action of the plasmin for short incubation times and represents 1 +/- 0.2% of the original quantity of fibrinogen. Sodium Dodecyl Sulfate 175-197 fibrinogen beta chain Homo sapiens 24-34 147811-1 1978 The incubation of human fibrinogen with plasmin gives rise to an early degradation product with a molecular weight of 63,000, calculated by polyacrylamide-gel electrophoresis sodium dodecyl sulfate (PAGE-SDS); this product is resistant to the action of the plasmin for short incubation times and represents 1 +/- 0.2% of the original quantity of fibrinogen. page-sds 199-207 fibrinogen beta chain Homo sapiens 24-34 147811-5 1978 As the 63,000 MW fragment has a reaction against fibrinogen fragment D antiserum and also contains PAS positive material, according to Pepper and co-workers, it can be taken to arise from the HOOC-terminal region of fibrinogen. Aminosalicylic Acid 99-102 fibrinogen beta chain Homo sapiens 216-226 658786-3 1978 Addition of human fibrinogen to the Tyrode-suspending buffer was required for ADP and epinephrine, but was not necessary for trypsin or collagen. tyrode 36-42 fibrinogen beta chain Homo sapiens 18-28 33082-2 1978 When serial fibrinogen levels fell below 100 mg% and the prothrombin time was significantly prolonged, intravenously injected heparin corrected hypofibrinogenemia. Heparin 126-133 fibrinogen beta chain Homo sapiens 12-22 658786-3 1978 Addition of human fibrinogen to the Tyrode-suspending buffer was required for ADP and epinephrine, but was not necessary for trypsin or collagen. Adenosine Diphosphate 78-81 fibrinogen beta chain Homo sapiens 18-28 658786-3 1978 Addition of human fibrinogen to the Tyrode-suspending buffer was required for ADP and epinephrine, but was not necessary for trypsin or collagen. Epinephrine 86-97 fibrinogen beta chain Homo sapiens 18-28 339827-3 1977 A decrease in the fibrinogen level was found in the mastitis patients treated with semi-synthetic penicillins and cephaloridin. Penicillins 98-109 fibrinogen beta chain Homo sapiens 18-28 627728-1 1978 Analysis of the zymosan (Z)-induced human platelet response with washed platelets, fresh agammaglobulinemic plasma, and purified human IgG has identified a previously unrecognized role of IgG in this reaction, in addition to the previously reported requirements for C and fibrinogen. Zymosan 16-23 fibrinogen beta chain Homo sapiens 272-282 146273-1 1977 The molecular weights of derivatives obtained from chemical and enzymatic degradation of fibrinogen and fibrin support a model in which the two halves of the fibrinogen molecule are covalently linked by a set of disulfide bonds at the amino-terminal region. Disulfides 212-221 fibrinogen beta chain Homo sapiens 89-99 146273-1 1977 The molecular weights of derivatives obtained from chemical and enzymatic degradation of fibrinogen and fibrin support a model in which the two halves of the fibrinogen molecule are covalently linked by a set of disulfide bonds at the amino-terminal region. Disulfides 212-221 fibrinogen beta chain Homo sapiens 158-168 339827-3 1977 A decrease in the fibrinogen level was found in the mastitis patients treated with semi-synthetic penicillins and cephaloridin. Cephaloridine 114-126 fibrinogen beta chain Homo sapiens 18-28 929373-3 1977 We have utilized autologous 125I-labelled fibrinogen to assess fibrinogen half-life in normal subjects and in patients with clotting complications before and after the administration of anticoagulants. Iodine-125 28-32 fibrinogen beta chain Homo sapiens 42-52 599832-1 1977 Using 125I-labelled fibrinogen the metabolism of this protein was studied in 29 patients with II-III stage congestive circulatory insufficiency due to ischemic heart disease and rheumatic heart diseases. Iodine-125 6-10 fibrinogen beta chain Homo sapiens 20-30 929373-3 1977 We have utilized autologous 125I-labelled fibrinogen to assess fibrinogen half-life in normal subjects and in patients with clotting complications before and after the administration of anticoagulants. Iodine-125 28-32 fibrinogen beta chain Homo sapiens 63-73 602311-0 1977 [Occurrence and behavior of fibrin fibrinogen degradation products in concentrates of factor VIII, cryoprecipitate and dextran precipitate during long-term preservation]. Dextrans 119-126 fibrinogen beta chain Homo sapiens 35-45 908137-1 1977 A fast and simple fibrinogen determination is presented, based on the ammonium sulfate precipitation of fibrinogen. Ammonium Sulfate 70-86 fibrinogen beta chain Homo sapiens 18-28 144599-0 1977 Stability of the disulfide bonds of fibrinogen and identification of specific subsets of surface-oriented histidine residue highly susceptible to alkylation. Disulfides 17-26 fibrinogen beta chain Homo sapiens 36-46 908137-1 1977 A fast and simple fibrinogen determination is presented, based on the ammonium sulfate precipitation of fibrinogen. Ammonium Sulfate 70-86 fibrinogen beta chain Homo sapiens 104-114 19499-0 1977 Interactions among heparin, cold-insoluble globulin, and fibrinogen in formation of the heparin-precipitable fraction of plasma. Heparin 88-95 fibrinogen beta chain Homo sapiens 57-67 924364-0 1977 Complex formation of crosslinked fibrin oligomers with agarose-coupled fibrinogen and fibrin. Sepharose 55-62 fibrinogen beta chain Homo sapiens 71-81 924364-4 1977 These fractions were subjected to affinity chromatography on agarose-coupled fibrinogen and fibrin. Sepharose 61-68 fibrinogen beta chain Homo sapiens 77-87 561325-8 1977 Fibrinogen showed a tendency to increase gradually after the administration of t-AMCHA, and this increase of fibrinogen would be one of the alarming signs of the development of ischemic complications. Tranexamic Acid 79-86 fibrinogen beta chain Homo sapiens 0-10 561325-8 1977 Fibrinogen showed a tendency to increase gradually after the administration of t-AMCHA, and this increase of fibrinogen would be one of the alarming signs of the development of ischemic complications. Tranexamic Acid 79-86 fibrinogen beta chain Homo sapiens 109-119 69596-2 1977 It was possible to provide objective data by means of the 125I-fibrinogen test for accelerated regression of thrombi following treatment with organo-heparinoid. organo-heparinoid 142-159 fibrinogen beta chain Homo sapiens 63-73 68091-1 1977 Correlation of plasma fibrinogen chromatographic findings with 125I-labeled fibrinogen scan findings. Iodine-125 63-67 fibrinogen beta chain Homo sapiens 22-32 68091-1 1977 Correlation of plasma fibrinogen chromatographic findings with 125I-labeled fibrinogen scan findings. Iodine-125 63-67 fibrinogen beta chain Homo sapiens 76-86 560684-0 1977 Influence of fibrinogen degradation products on the action of amphetamine in the central nervous system. Amphetamine 62-73 fibrinogen beta chain Homo sapiens 13-23 560684-1 1977 Fibrinogen degradation products (FDP) in a dose dependent manner potentiated the action of amphetamine in the tests for locomotor activity (Knoll"s motimeter) and stereotypy. Amphetamine 91-102 fibrinogen beta chain Homo sapiens 0-10 139916-8 1977 The overlap with key cyanogen bromide fragments has also allowed us to propose an order for the first 198 residues of the fibrinogen alpha chain. Cyanogen Bromide 21-37 fibrinogen beta chain Homo sapiens 122-132 851527-2 1977 Fully cross-linked human fibrin was digested with cyanogen bromide and the resulting fragments were characterized and compared with the fragments produced upon cyanogen bromide treatment of fibrinogen alpha chains. Cyanogen Bromide 160-176 fibrinogen beta chain Homo sapiens 190-200 851527-5 1977 The identified sequences corresponded to two cyanogen bromide fragments previously found in alpha chains isolated from fibrinogen, one of which has a molecular weight of about 30 000 and the other 6000. Cyanogen Bromide 45-61 fibrinogen beta chain Homo sapiens 119-129 916354-2 1977 This fraction, although seemed to resemble macromolecular FDP (fibrinogen degradation product) derived from stabilized fibrin, has many features not shared with the latter: 1) This fraction is sensitive to sodium dodecylsulfate (SDS) treatment. Sodium Dodecyl Sulfate 206-227 fibrinogen beta chain Homo sapiens 63-73 916354-2 1977 This fraction, although seemed to resemble macromolecular FDP (fibrinogen degradation product) derived from stabilized fibrin, has many features not shared with the latter: 1) This fraction is sensitive to sodium dodecylsulfate (SDS) treatment. Sodium Dodecyl Sulfate 229-232 fibrinogen beta chain Homo sapiens 63-73 653643-0 1978 Lithium inhibition of ristocetin-induced fibrinogen precipitation. Lithium 0-7 fibrinogen beta chain Homo sapiens 41-51 653643-0 1978 Lithium inhibition of ristocetin-induced fibrinogen precipitation. Ristocetin 22-32 fibrinogen beta chain Homo sapiens 41-51 580505-2 1978 Autologous I-125-labeled fibrinogen (I-125-fibrinogen) was used as a tracer. Iodine-125 11-16 fibrinogen beta chain Homo sapiens 25-35 20154-0 1977 The binding of calcium to fibrinogen: some structural features. Calcium 15-22 fibrinogen beta chain Homo sapiens 26-36 20154-1 1977 Experiments are described which suggest that structural features are related to the existence of three high affinity calcium-binding sites in the fibrinogen molecule. Calcium 117-124 fibrinogen beta chain Homo sapiens 146-156 20154-4 1977 At pH 5.0 calcium-free fibrinogen is slightly acid-denatured. Calcium 10-17 fibrinogen beta chain Homo sapiens 23-33 20154-9 1977 Resistance to proteolysis by plasmin is observed when calcium is bound to fibrinogen. Calcium 54-61 fibrinogen beta chain Homo sapiens 74-84 20154-12 1977 And that the calcium divalent cation stabilizes a more compact structure of the fibrinogen molecule. Calcium 13-20 fibrinogen beta chain Homo sapiens 80-90 890918-3 1977 The initial velocity of ammonia production is directly proportional to the fibrinogen concentration in plasma. Ammonia 24-31 fibrinogen beta chain Homo sapiens 75-85 890918-5 1977 A maximum of 6.4 +/- 1.5 (SD) molecules of ammonia are produced per molecule of fibrinogen. Ammonia 43-50 fibrinogen beta chain Homo sapiens 80-90 888974-0 1977 Inhibition of fibrin-platelet interactions by fibrinogen-degradation fragment D. Homogenized fibrin induced platelet aggregation and the release of serotonin from human platelets. Serotonin 148-157 fibrinogen beta chain Homo sapiens 46-56 142315-0 1977 Protective effect of calcium in the plasmin degradation of fibrinogen and fibrin fragments D. Calcium 21-28 fibrinogen beta chain Homo sapiens 59-69 326134-2 1977 This is probably due to an interaction of heparin and serum proteins, together with either fibrinogen or polyethylene glycol. Heparin 42-49 fibrinogen beta chain Homo sapiens 91-101 327607-1 1977 We have shown previously that washed human platelets resuspended in Tyrode solution containing albumin and apyrase maintain their disc shape and their ability to aggregate upon the addition of low concentration of ADP, providing fibrinogen is added to the suspending medium. tyrode 68-74 fibrinogen beta chain Homo sapiens 229-239 327607-1 1977 We have shown previously that washed human platelets resuspended in Tyrode solution containing albumin and apyrase maintain their disc shape and their ability to aggregate upon the addition of low concentration of ADP, providing fibrinogen is added to the suspending medium. Adenosine Diphosphate 214-217 fibrinogen beta chain Homo sapiens 229-239 577627-6 1977 Thyroidectomy and thyroxine-injection markedly altered fibrinogen metabolism: thyroid hormone accelerated fibrinogen catabolism but also stimulated synthesis. Thyroxine 18-27 fibrinogen beta chain Homo sapiens 55-65 577627-6 1977 Thyroidectomy and thyroxine-injection markedly altered fibrinogen metabolism: thyroid hormone accelerated fibrinogen catabolism but also stimulated synthesis. Thyroxine 18-27 fibrinogen beta chain Homo sapiens 106-116 577627-8 1977 The interstitial/plasma fibrinogen ratio decreased in thyroxine-treated, and increased in thyroidectomized animals. Thyroxine 54-63 fibrinogen beta chain Homo sapiens 24-34 856391-2 1977 After six months" treatment with stanozolol their mean dilute blood clot lysis time and plasma fibrinogen fell significantly and the mean fibrin plate lysis area increased. Stanozolol 33-43 fibrinogen beta chain Homo sapiens 95-105 843621-0 1977 Significance of the intact polypeptide chains of human fibrinogen in ADP-induced platelet aggregation. Adenosine Diphosphate 69-72 fibrinogen beta chain Homo sapiens 55-65 843621-1 1977 The presence of human fibrinogen in suspensions of washed human platelets is a requirement for ADP-induced platelet aggregation. Adenosine Diphosphate 95-98 fibrinogen beta chain Homo sapiens 22-32 843621-3 1977 The high solubility fraction of Kabi fibrinogen, fragment X (stage 1) and framgent X (stage 2), are two, eight, and ten times, respectively, less potent in promoting ADP-induced platelet aggregation, as compared with intact fibrinogen. Adenosine Diphosphate 166-169 fibrinogen beta chain Homo sapiens 37-47 843621-5 1977 SDS polyacrylamide gel electrophoresis of nonreduced and reduced fibrinogen and its derivatives indicates that the intact fibrinogen molecule is essential for ADP-induced platelet aggregation. Sodium Dodecyl Sulfate 0-3 fibrinogen beta chain Homo sapiens 65-75 843621-5 1977 SDS polyacrylamide gel electrophoresis of nonreduced and reduced fibrinogen and its derivatives indicates that the intact fibrinogen molecule is essential for ADP-induced platelet aggregation. Sodium Dodecyl Sulfate 0-3 fibrinogen beta chain Homo sapiens 122-132 843621-5 1977 SDS polyacrylamide gel electrophoresis of nonreduced and reduced fibrinogen and its derivatives indicates that the intact fibrinogen molecule is essential for ADP-induced platelet aggregation. polyacrylamide 4-18 fibrinogen beta chain Homo sapiens 65-75 843621-5 1977 SDS polyacrylamide gel electrophoresis of nonreduced and reduced fibrinogen and its derivatives indicates that the intact fibrinogen molecule is essential for ADP-induced platelet aggregation. polyacrylamide 4-18 fibrinogen beta chain Homo sapiens 122-132 843621-5 1977 SDS polyacrylamide gel electrophoresis of nonreduced and reduced fibrinogen and its derivatives indicates that the intact fibrinogen molecule is essential for ADP-induced platelet aggregation. Adenosine Diphosphate 159-162 fibrinogen beta chain Homo sapiens 65-75 843621-5 1977 SDS polyacrylamide gel electrophoresis of nonreduced and reduced fibrinogen and its derivatives indicates that the intact fibrinogen molecule is essential for ADP-induced platelet aggregation. Adenosine Diphosphate 159-162 fibrinogen beta chain Homo sapiens 122-132 843621-6 1977 It is suggested that the carboxy-terminal part of the Aalpha chain and possibly also the amino-terminal part of the Bbeta chain are required for the platelet aggregation-promoting function of fibrinogen. bbeta 116-121 fibrinogen beta chain Homo sapiens 192-202 905334-4 1977 Fibrinogen labelled with iodine 131 however permits an exact control of what is happening at the site of the sclerosant injection. Iodine 25-31 fibrinogen beta chain Homo sapiens 0-10 861306-1 1977 It is found by means of different methods (the administration of 35S-heparin, the determination of fibrinolytic activity of blood plasma fractions containing fibrinogen degradation products and fibrinogen--heparin complex, spectral analysis of fibrinogen--heparin complex etc. Heparin 206-213 fibrinogen beta chain Homo sapiens 194-204 861306-1 1977 It is found by means of different methods (the administration of 35S-heparin, the determination of fibrinolytic activity of blood plasma fractions containing fibrinogen degradation products and fibrinogen--heparin complex, spectral analysis of fibrinogen--heparin complex etc. Heparin 206-213 fibrinogen beta chain Homo sapiens 194-204 870006-1 1977 A mica adsorption technique was used to prepare fibrinogen and early fibrin polymers for examination in the transmission electron microscope. mica 2-6 fibrinogen beta chain Homo sapiens 48-58 140169-0 1977 Interactions between segmented polyurethane surfaces and the plasma protein fibrinogen. Polyurethanes 31-43 fibrinogen beta chain Homo sapiens 76-86 140169-3 1977 Adsorption, and possible conformational changes of fibrinogen, were found to be more substantial on polymer surfaces having a higher content of polyether segments. Polymers 100-107 fibrinogen beta chain Homo sapiens 51-61 140169-3 1977 Adsorption, and possible conformational changes of fibrinogen, were found to be more substantial on polymer surfaces having a higher content of polyether segments. polyether 144-153 fibrinogen beta chain Homo sapiens 51-61 14416-2 1977 The influence of the pH on the separation of high molecular weight derivatives obtained by a limited action of thrombin on fibrinogen was studied by agarose gel chromatography. Sepharose 149-156 fibrinogen beta chain Homo sapiens 123-133 138448-3 1977 The clots dissolved gradually within 2 days (fibrin from sodium p-chloromercuribenzoate-treated fibrinogen) to 15 days (fibrin from factor XIII-enriched fibrinogen). 4-hydroxymercuribenzoate 57-87 fibrinogen beta chain Homo sapiens 96-106 839676-5 1977 Users of Ovulen (0.1 mg mestranol, 1 mg ethynodiol diacetate) in addition to the rise of SFMC levels exhibited elevated fibrinogen levels in plasma. Mestranol 24-33 fibrinogen beta chain Homo sapiens 120-130 839676-5 1977 Users of Ovulen (0.1 mg mestranol, 1 mg ethynodiol diacetate) in addition to the rise of SFMC levels exhibited elevated fibrinogen levels in plasma. Ethynodiol Diacetate 40-60 fibrinogen beta chain Homo sapiens 120-130 833473-1 1977 The role of sialic acid in the functional and metabolic properties of purified human fibrinogen was investigated. N-Acetylneuraminic Acid 12-23 fibrinogen beta chain Homo sapiens 85-95 833473-2 1977 Fibrinogen treated with Vibrio cholerae neuraminidase released 90 percent of its sialic acid without evidence of proteolysis, as indicated by the presence of intace A alpha, B beta, and gamma chains on sodium dodecylsulfate (SDS)-polyacrylamide gels of the reduced asialoprotein. N-Acetylneuraminic Acid 81-92 fibrinogen beta chain Homo sapiens 0-10 833473-2 1977 Fibrinogen treated with Vibrio cholerae neuraminidase released 90 percent of its sialic acid without evidence of proteolysis, as indicated by the presence of intace A alpha, B beta, and gamma chains on sodium dodecylsulfate (SDS)-polyacrylamide gels of the reduced asialoprotein. Sodium Dodecyl Sulfate 202-223 fibrinogen beta chain Homo sapiens 0-10 833473-2 1977 Fibrinogen treated with Vibrio cholerae neuraminidase released 90 percent of its sialic acid without evidence of proteolysis, as indicated by the presence of intace A alpha, B beta, and gamma chains on sodium dodecylsulfate (SDS)-polyacrylamide gels of the reduced asialoprotein. Sodium Dodecyl Sulfate 225-228 fibrinogen beta chain Homo sapiens 0-10 833473-2 1977 Fibrinogen treated with Vibrio cholerae neuraminidase released 90 percent of its sialic acid without evidence of proteolysis, as indicated by the presence of intace A alpha, B beta, and gamma chains on sodium dodecylsulfate (SDS)-polyacrylamide gels of the reduced asialoprotein. polyacrylamide 230-244 fibrinogen beta chain Homo sapiens 0-10 409019-7 1977 CR was more frequent in patients with a very low blast cell count and a fibrinogen level higher than 100 mg/100 ml. Chromium 0-2 fibrinogen beta chain Homo sapiens 72-82 104706-0 1977 Influence of NA2-EDTA and some compounds used for dissolution of fibrin clots on the physiochemical properties of fibrinogen and fibrin. Edetic Acid 13-21 fibrinogen beta chain Homo sapiens 114-124 617779-2 1977 Incorporation of fibrin in thrombi may be detected by usine 125I-labelled fibrinogen. usine 125i 54-64 fibrinogen beta chain Homo sapiens 74-84 617780-1 1977 Affinity chromatographic studies using insolubilized fibrinogen (fibrinogen-agarose) revealed that fibrin monomer present in plasma is selectively adsorbed to fibrinogen-agarose and may be quantitatively estimated following desorption. Sepharose 76-83 fibrinogen beta chain Homo sapiens 53-63 617780-1 1977 Affinity chromatographic studies using insolubilized fibrinogen (fibrinogen-agarose) revealed that fibrin monomer present in plasma is selectively adsorbed to fibrinogen-agarose and may be quantitatively estimated following desorption. Sepharose 76-83 fibrinogen beta chain Homo sapiens 65-75 617780-1 1977 Affinity chromatographic studies using insolubilized fibrinogen (fibrinogen-agarose) revealed that fibrin monomer present in plasma is selectively adsorbed to fibrinogen-agarose and may be quantitatively estimated following desorption. Sepharose 76-83 fibrinogen beta chain Homo sapiens 65-75 617780-1 1977 Affinity chromatographic studies using insolubilized fibrinogen (fibrinogen-agarose) revealed that fibrin monomer present in plasma is selectively adsorbed to fibrinogen-agarose and may be quantitatively estimated following desorption. Sepharose 170-177 fibrinogen beta chain Homo sapiens 65-75 617780-1 1977 Affinity chromatographic studies using insolubilized fibrinogen (fibrinogen-agarose) revealed that fibrin monomer present in plasma is selectively adsorbed to fibrinogen-agarose and may be quantitatively estimated following desorption. Sepharose 170-177 fibrinogen beta chain Homo sapiens 65-75 617780-4 1977 Standard conditions for the procedure were evaluated using 3H-labelled fibrinogen and fibrin monomer. Tritium 59-61 fibrinogen beta chain Homo sapiens 71-81 869991-4 1977 Treatment of platelets with PGE1 (100 microng/ml) markedly inhibits (greater than 80%) the release of platelet fibrinogen induced by thrombin. Alprostadil 28-32 fibrinogen beta chain Homo sapiens 111-121 148961-2 1977 In order to elucidate the mechanism of fibrinogen kinetic abnormalities different drugs, including heparin, prednisone, ticlopidin, aspirin and indomethacin were administered in 68 patients and their effects evaluated by change in the 311I fibrinogen disappearance rate. Heparin 99-106 fibrinogen beta chain Homo sapiens 39-49 148961-2 1977 In order to elucidate the mechanism of fibrinogen kinetic abnormalities different drugs, including heparin, prednisone, ticlopidin, aspirin and indomethacin were administered in 68 patients and their effects evaluated by change in the 311I fibrinogen disappearance rate. Prednisone 108-118 fibrinogen beta chain Homo sapiens 39-49 148961-2 1977 In order to elucidate the mechanism of fibrinogen kinetic abnormalities different drugs, including heparin, prednisone, ticlopidin, aspirin and indomethacin were administered in 68 patients and their effects evaluated by change in the 311I fibrinogen disappearance rate. Ticlopidine 120-130 fibrinogen beta chain Homo sapiens 39-49 148961-2 1977 In order to elucidate the mechanism of fibrinogen kinetic abnormalities different drugs, including heparin, prednisone, ticlopidin, aspirin and indomethacin were administered in 68 patients and their effects evaluated by change in the 311I fibrinogen disappearance rate. Indomethacin 144-156 fibrinogen beta chain Homo sapiens 39-49 321184-2 1977 The volunteers taking the oxpenifylline showed a significant increase in their fibrinolytic activity, as assessed by the dilute blood clot lysis time and fibrin plate lysis area, and a significant reduction in their plasma fibrinogen levels. oxpenifylline 26-39 fibrinogen beta chain Homo sapiens 223-233 321184-4 1977 These findings suggest that oxpentifylline may be valuable in the treatment of small vessel occlusive disease associated with lowered fibrinolytic activity and raised fibrinogen levels. Pentoxifylline 28-42 fibrinogen beta chain Homo sapiens 167-177 18381-2 1977 When exposed to acetic acid at room temperature, fibrinogen precipitated almost immediately and quantitatively. Acetic Acid 16-27 fibrinogen beta chain Homo sapiens 49-59 18381-3 1977 Subsequent dialysis for 72 h against 0.3 M NaCl, pH 7.4, caused resolution of fibrinogen to a varying degree, the amount depending on the time of exposure. Sodium Chloride 43-47 fibrinogen beta chain Homo sapiens 78-88 18381-5 1977 Fibrinogen exposed to 1 M NaBr, pH 5.2, at room temperature for 1 h showed a slightly shortened thrombin clotting time and a broadened chromatographic profile. sodium bromide 26-30 fibrinogen beta chain Homo sapiens 0-10 18381-7 1977 Similar findings were obtained with fibrinogen exposed to 5 M urea, pH 7.4. Urea 62-66 fibrinogen beta chain Homo sapiens 36-46 615088-1 1977 The metabolism and in vivo kinetics of fibrinogen labelled with radioactive iodine was studied in children with cyanotic congenital heart disease. Iodine 76-82 fibrinogen beta chain Homo sapiens 39-49 615088-4 1977 The shortened fibrinogen half-life together with the correcting effect of anticoagulation with heparin indicated that fibrinogen was consumed by chronic disseminated intravascular coagulation. Heparin 95-102 fibrinogen beta chain Homo sapiens 118-128 914081-0 1977 Preparation of fibrin monomers from human fibrinogen in urea, using soluble or insolubilized thrombin. Urea 56-60 fibrinogen beta chain Homo sapiens 42-52 929119-1 1977 In this study, 131I-labeled human plasma fibrinogen (200 muCi) was injected intravenously into 21 patients with rheumatoid arthritis and 10 control patients without rheumatic diseases. Iodine-131 15-19 fibrinogen beta chain Homo sapiens 41-51 1020408-1 1976 The influence of stanozolol Stromba and phenformin Dibotin (Winthrop) and complamin (Wulfing) on transformation of 131J-fibrinogen administered intravenously was examined in 39 patients with arteriosclerosis obliterans. Stanozolol 17-27 fibrinogen beta chain Homo sapiens 120-130 1020408-1 1976 The influence of stanozolol Stromba and phenformin Dibotin (Winthrop) and complamin (Wulfing) on transformation of 131J-fibrinogen administered intravenously was examined in 39 patients with arteriosclerosis obliterans. Xanthinol Niacinate 74-83 fibrinogen beta chain Homo sapiens 120-130 1020408-6 1976 But in patients who received complamin in spite of significant decrease of the plasma fibrinogen (g%), the fibrinogen degradation was not different from the value obtained in the group. Xanthinol Niacinate 29-38 fibrinogen beta chain Homo sapiens 86-96 1020408-6 1976 But in patients who received complamin in spite of significant decrease of the plasma fibrinogen (g%), the fibrinogen degradation was not different from the value obtained in the group. Xanthinol Niacinate 29-38 fibrinogen beta chain Homo sapiens 107-117 1036567-1 1976 Use of 125I-labeled fibrinogen in patients with acute myocardial infarction. Iodine-125 7-11 fibrinogen beta chain Homo sapiens 20-30 1036567-2 1976 Fibrinogen labeled with iodine 125 was used to detect deep vein thrombosis (DVT) in 35 patients during their course and convalescence from acute myocardial infarction. Iodine 24-30 fibrinogen beta chain Homo sapiens 0-10 998569-5 1976 The high fibrinogen level in cancer patients was related to increased concentrations of HMW and LMW fractions, whereas in the vascular-disease patients it was due exclusively to increased concentrations of LMW and LMW" fibrinogen. 2-(4-Amino-N-ethylanilino)ethanol 96-99 fibrinogen beta chain Homo sapiens 9-19 999000-0 1976 Infrared spectrophotometric observations of the adsorption of fibrinogen from solution at optically transparent carbon film electrode surfaces. Carbon 112-118 fibrinogen beta chain Homo sapiens 62-72 1008913-0 1976 Influence of Etofibrate on plasma fibrinogen and plasminogen concentrations in patients with different forms of primary hyperlipoproteinemia. etofibrate 13-23 fibrinogen beta chain Homo sapiens 34-44 1008913-1 1976 The effect of Etofibrate, a chemical compound of the two antihyperlipidemic agents Clofibrate and nicotinic acid, on elevated plasma fibrinogen and plasminogen concentrations was investigated in a 6 months" survey in 25 patients with different types of primary hyperlipidemia. etofibrate 14-24 fibrinogen beta chain Homo sapiens 133-143 1008913-1 1976 The effect of Etofibrate, a chemical compound of the two antihyperlipidemic agents Clofibrate and nicotinic acid, on elevated plasma fibrinogen and plasminogen concentrations was investigated in a 6 months" survey in 25 patients with different types of primary hyperlipidemia. Clofibrate 83-93 fibrinogen beta chain Homo sapiens 133-143 1008913-1 1976 The effect of Etofibrate, a chemical compound of the two antihyperlipidemic agents Clofibrate and nicotinic acid, on elevated plasma fibrinogen and plasminogen concentrations was investigated in a 6 months" survey in 25 patients with different types of primary hyperlipidemia. Niacin 98-112 fibrinogen beta chain Homo sapiens 133-143 1008913-3 1976 The fibrinogen-lowering effect of Etofibrate was not related to the pretreatment levels but nearly equal in all cases. etofibrate 34-44 fibrinogen beta chain Homo sapiens 4-14 996834-0 1976 Isolation of residual fibrinogen from a supernatant of plasma precipitated with 2.1 M glycine. Glycine 86-93 fibrinogen beta chain Homo sapiens 22-32 971436-7 1976 Concanavalin A inhibited the ADP-induced aggregation of platelets suspended in plasma or in a salts solution supplemented with calcium and fibrinogen, although the inhibitory effect was more conspicuous in the latter case. Adenosine Diphosphate 29-32 fibrinogen beta chain Homo sapiens 139-149 19499-1 1977 Fibrinogen and the cold-insoluble globulin of plasma (CIg) are the main protein components of the heparin-precipitable fraction of normal plasma. Heparin 98-105 fibrinogen beta chain Homo sapiens 0-10 19499-3 1977 Heparin formed a cold-precipitable complex with purified CIg or with mixtures of CIg and fibrinogen but not with purified fibrinogen alone. Heparin 0-7 fibrinogen beta chain Homo sapiens 89-99 19499-5 1977 Fibrinogen reduced the threshold for heparin-induced CIg cryoprecipitation and, by coprecipitating with heparin and CIg, increased the amount of precipitate that formed. Heparin 37-44 fibrinogen beta chain Homo sapiens 0-10 19499-5 1977 Fibrinogen reduced the threshold for heparin-induced CIg cryoprecipitation and, by coprecipitating with heparin and CIg, increased the amount of precipitate that formed. Heparin 104-111 fibrinogen beta chain Homo sapiens 0-10 19499-6 1977 In contrast to the heparin-precipitable fraction of normal plasma which contained both fibrinogen and CIg, that from a patient with congenital afibrinogenemia contained CIg but lacked fibrinogen. Heparin 19-26 fibrinogen beta chain Homo sapiens 87-97 19499-9 1977 Fibrinogen, as assessed by chromatographic experiments with heparin-Sepharose columns, had a considerably lower binding affinity for heparin than did CIg, suggesting that it participates in precipitate formation mainly, if not entirely, by virtue of its affinity for CIg. Heparin 60-67 fibrinogen beta chain Homo sapiens 0-10 19499-9 1977 Fibrinogen, as assessed by chromatographic experiments with heparin-Sepharose columns, had a considerably lower binding affinity for heparin than did CIg, suggesting that it participates in precipitate formation mainly, if not entirely, by virtue of its affinity for CIg. Sepharose 68-77 fibrinogen beta chain Homo sapiens 0-10 19499-9 1977 Fibrinogen, as assessed by chromatographic experiments with heparin-Sepharose columns, had a considerably lower binding affinity for heparin than did CIg, suggesting that it participates in precipitate formation mainly, if not entirely, by virtue of its affinity for CIg. Heparin 133-140 fibrinogen beta chain Homo sapiens 0-10 19499-10 1977 The region of the fibrinogen molecule accounting for its precipitation with CIg appears to be localized in the carboxy-terminal segment of the Aalpha-chain; fibrinogen subfractions lacking this region failed to augment cryoprecipitation of heparin-CIg mixtures and, even though such species were present in normal plasma, they failed to coprecipitate in the heparin-induced complex. Heparin 240-247 fibrinogen beta chain Homo sapiens 18-28 19499-10 1977 The region of the fibrinogen molecule accounting for its precipitation with CIg appears to be localized in the carboxy-terminal segment of the Aalpha-chain; fibrinogen subfractions lacking this region failed to augment cryoprecipitation of heparin-CIg mixtures and, even though such species were present in normal plasma, they failed to coprecipitate in the heparin-induced complex. Heparin 358-365 fibrinogen beta chain Homo sapiens 18-28 183820-7 1976 The plasma proteins albumin and fibrinogen were also found to differentially affect the lipid hydrocarbon C-H stretch Raman nodes. lipid hydrocarbon c 88-107 fibrinogen beta chain Homo sapiens 32-42 982348-0 1976 Adsorption of glass and polyethylene from solutions of fibrinogen and albumin. Polyethylene 24-36 fibrinogen beta chain Homo sapiens 55-65 1036803-2 1976 Eight groups of fibrinogen derivatives could be separated by gel filtration through 6% agarose in large columns, four with an elution volume smaller and four groups with an elution volume larger than that of fibrinogen. Sepharose 87-94 fibrinogen beta chain Homo sapiens 16-26 952908-8 1976 Human fibrinogen and bovin serum albumin were found to increase the I2890/I2850 dimyristoyl phosphatidylcholine Raman intensity ratio while decreasing the I2850/I2930 dimyristoyl phosphatidylcholine Raman intensity ratio indicating that the lipid underwent a conformational change and that the hydrocarbon chain environment was more polar in the presence of albumin or fibrinogen. Phosphatidylcholines 92-111 fibrinogen beta chain Homo sapiens 6-16 952908-8 1976 Human fibrinogen and bovin serum albumin were found to increase the I2890/I2850 dimyristoyl phosphatidylcholine Raman intensity ratio while decreasing the I2850/I2930 dimyristoyl phosphatidylcholine Raman intensity ratio indicating that the lipid underwent a conformational change and that the hydrocarbon chain environment was more polar in the presence of albumin or fibrinogen. Phosphatidylcholines 179-198 fibrinogen beta chain Homo sapiens 6-16 952908-8 1976 Human fibrinogen and bovin serum albumin were found to increase the I2890/I2850 dimyristoyl phosphatidylcholine Raman intensity ratio while decreasing the I2850/I2930 dimyristoyl phosphatidylcholine Raman intensity ratio indicating that the lipid underwent a conformational change and that the hydrocarbon chain environment was more polar in the presence of albumin or fibrinogen. Hydrocarbons 294-305 fibrinogen beta chain Homo sapiens 6-16 10637-1 1976 The reactivity of fibrinogen crosslinking sites with thrombin-free, preactivated factor XIII (F. XIIIa) was investigated under different conditions such as increased ionic strength, presence of urea, protamine sulfate (PS) or of varying concentrations of monodansylcadaverine (MDC). Urea 194-198 fibrinogen beta chain Homo sapiens 18-28 10637-1 1976 The reactivity of fibrinogen crosslinking sites with thrombin-free, preactivated factor XIII (F. XIIIa) was investigated under different conditions such as increased ionic strength, presence of urea, protamine sulfate (PS) or of varying concentrations of monodansylcadaverine (MDC). monodansylcadaverine 255-275 fibrinogen beta chain Homo sapiens 18-28 861306-0 1977 [Presence of an active fibrinogen--heparin complex in the total blood plasma fraction of plasma fibrinogen degradation products]. Heparin 35-42 fibrinogen beta chain Homo sapiens 23-33 861306-0 1977 [Presence of an active fibrinogen--heparin complex in the total blood plasma fraction of plasma fibrinogen degradation products]. Heparin 35-42 fibrinogen beta chain Homo sapiens 96-106 989976-1 1976 Characteristic changes induced by dextran during the conversion of fibrinogen to fibrin have previously been shown to be associated with profound alterations in morphology of fibrin. Dextrans 34-41 fibrinogen beta chain Homo sapiens 67-77 934880-2 1976 The authors studied the metabolism of fibrinogen labelled with iodine 125 in 57 cirrhotic patients and 25 controls. Iodine 63-69 fibrinogen beta chain Homo sapiens 38-48 1269136-2 1976 Fibrinogen is isolated from plasma by a rapid salting-out method with ammonium sulfate and is iodinated with chloramine T. Ammonium Sulfate 70-86 fibrinogen beta chain Homo sapiens 0-10 1269136-2 1976 Fibrinogen is isolated from plasma by a rapid salting-out method with ammonium sulfate and is iodinated with chloramine T. chloramine-T 109-121 fibrinogen beta chain Homo sapiens 0-10 781183-1 1976 Bovine serum albumin, gelatin, fibrinogen and pepsin impaired the attachment of a marine pseudomonad to polystyrene Petri dishes, apparently through adsorption on the dish surface. Polystyrenes 104-115 fibrinogen beta chain Homo sapiens 31-41 939805-0 1976 A rapidly produced 125I labelled autologous fibrinogen: in vitro properties and preliminary metabolic studies in man. Iodine-125 19-23 fibrinogen beta chain Homo sapiens 44-54 939805-1 1976 The properties of fibrinogen extracted by a precipitation method using glycine at ambient temperatures near neutral pH are described. Glycine 71-78 fibrinogen beta chain Homo sapiens 18-28 960050-0 1976 A simplified method for isolation of the S-carboxymethyl derivative chains of normal fibrinogen and fibrinogen Cleveland and I. Sulfur 41-42 fibrinogen beta chain Homo sapiens 85-95 960050-0 1976 A simplified method for isolation of the S-carboxymethyl derivative chains of normal fibrinogen and fibrinogen Cleveland and I. Sulfur 41-42 fibrinogen beta chain Homo sapiens 100-110 960050-0 1976 A simplified method for isolation of the S-carboxymethyl derivative chains of normal fibrinogen and fibrinogen Cleveland and I. carboxymethyl-coenzyme A 43-56 fibrinogen beta chain Homo sapiens 85-95 960051-0 1976 Fibrinogen structure after spraying on mica: assessing the electron microscopic basis for a trinodular model. mica 39-43 fibrinogen beta chain Homo sapiens 0-10 997524-1 1976 Based on the frequency of subclinical, postoperative thrombosis which we detected using radio-iodine-tagged fibrinogen (125I-fibrinogen) in 2 comparable test groups of 100 female patients each, we were able to compare the effectiveness of Aescin (Reparil) to the untreated group. Iodine 94-100 fibrinogen beta chain Homo sapiens 108-118 1266716-3 1976 Seven patients had been given 125I-and five patients 131I-labeled fibrinogen. Iodine-131 53-57 fibrinogen beta chain Homo sapiens 66-76 58987-6 1976 Albumin adsorption onto phthalate-contaminated surfaces is less than on cleansed surfaces while adsorption of gamma-globulin and fibrinogen is greater on phthalate-contaminated surfaces. phthalic acid 154-163 fibrinogen beta chain Homo sapiens 129-139 936108-0 1976 Disulfide bridges in nh2 -terminal part of human fibrinogen. Disulfides 0-9 fibrinogen beta chain Homo sapiens 49-59 989632-1 1976 Treatment of fibrinogen with maleic acid anhydride renders fibrinogen unclottable depending on the degree of modification of the molecule. Maleic Anhydrides 29-50 fibrinogen beta chain Homo sapiens 13-23 989632-1 1976 Treatment of fibrinogen with maleic acid anhydride renders fibrinogen unclottable depending on the degree of modification of the molecule. Maleic Anhydrides 29-50 fibrinogen beta chain Homo sapiens 59-69 1255254-0 1976 Circulation clearance rate of radioiodine during fibrinogen uptake tests. Iodine-131 30-41 fibrinogen beta chain Homo sapiens 49-59 1030755-0 1976 [Circulation time of 125I-labeled fibrinogen in patients with ischemic heart disease with different types of hyperlipoproteinemia]. Iodine-125 21-25 fibrinogen beta chain Homo sapiens 34-44 815259-3 1976 Fibrinogen Fragment E and fibrin Fragment E migrated as single bands with identical mobilities on sodium dodecyl sulfate-polyacrylamide gel electrophoresis or on polyacrylamide gel electrophoresis at pH 3.2 or pH 8.6. Sodium Dodecyl Sulfate 98-120 fibrinogen beta chain Homo sapiens 0-10 815259-3 1976 Fibrinogen Fragment E and fibrin Fragment E migrated as single bands with identical mobilities on sodium dodecyl sulfate-polyacrylamide gel electrophoresis or on polyacrylamide gel electrophoresis at pH 3.2 or pH 8.6. polyacrylamide 121-135 fibrinogen beta chain Homo sapiens 0-10 815259-3 1976 Fibrinogen Fragment E and fibrin Fragment E migrated as single bands with identical mobilities on sodium dodecyl sulfate-polyacrylamide gel electrophoresis or on polyacrylamide gel electrophoresis at pH 3.2 or pH 8.6. polyacrylamide 162-176 fibrinogen beta chain Homo sapiens 0-10 943180-2 1976 These fragments were the three-chain, NH2-terminal disulfide knot (N-DSK) produced by CNBr cleavage of fibrinogen, the reduced, carboxymethyl Aalpha chain portion of the N-DSK, and fragment E produced by plasmin digestion of fibrinogen. Disulfides 51-60 fibrinogen beta chain Homo sapiens 103-113 943180-2 1976 These fragments were the three-chain, NH2-terminal disulfide knot (N-DSK) produced by CNBr cleavage of fibrinogen, the reduced, carboxymethyl Aalpha chain portion of the N-DSK, and fragment E produced by plasmin digestion of fibrinogen. Disulfides 51-60 fibrinogen beta chain Homo sapiens 225-235 820599-0 1976 Fibrinogen survival with 75-seleniomethionine in acute myeloblastic leukemia during polychemotherapy. 75-seleniomethionine 25-45 fibrinogen beta chain Homo sapiens 0-10 1265709-0 1976 125I labeling of fibrinogen by the Chloramine-T-method without protein denaturation. chloramine-T 35-47 fibrinogen beta chain Homo sapiens 17-27 1061997-3 1976 Heparin infusion was twice accompanied by normalization of the fibrinogen level, but had to be stopped because of severe bleeding. Heparin 0-7 fibrinogen beta chain Homo sapiens 63-73 1253452-0 1976 The sulphite precipitation method for fibrinogen measurement; its use on small samples in the presence of fibrinogen degradation products. Sulfites 4-12 fibrinogen beta chain Homo sapiens 38-48 1253452-0 1976 The sulphite precipitation method for fibrinogen measurement; its use on small samples in the presence of fibrinogen degradation products. Sulfites 4-12 fibrinogen beta chain Homo sapiens 106-116 1253452-1 1976 A technique based on precipitation by sodium sulphite (Na2SO3) has been developed for measuring the fibrinogen concentration of small (100 mul) samples. sodium sulfite 38-53 fibrinogen beta chain Homo sapiens 100-110 1253452-1 1976 A technique based on precipitation by sodium sulphite (Na2SO3) has been developed for measuring the fibrinogen concentration of small (100 mul) samples. sodium sulfite 55-61 fibrinogen beta chain Homo sapiens 100-110 1253452-3 1976 Measurements made with the sulphite technique on fibrinogen solutions on plasma samples were not significantly different from those obtained with the thrombin-clotting method. Sulfites 27-35 fibrinogen beta chain Homo sapiens 49-59 1257034-0 1976 [The half-life of iodine 131-labelled fibrinogen in cancer patients. Iodine 18-24 fibrinogen beta chain Homo sapiens 38-48 1257034-7 1976 Heparine (15000 U/24h) restores the 1/2 T of fibrinogen to normal in 95 p. cent of cases. Heparin 0-8 fibrinogen beta chain Homo sapiens 45-55 1449-2 1976 The hydrolysis of all the proteins except fibrinogen and elastin was increased by addition of urea. Urea 94-98 fibrinogen beta chain Homo sapiens 42-52 59505-4 1976 In the early purpuric lesions from 6 patients with Schonlein-Henoch syndrome and from a patient with diseeminated vascular coagulation from acute allergic reaction to phenylbutazone, deposits of fibrinogen occurred mainly in the vessel walls. Phenylbutazone 167-181 fibrinogen beta chain Homo sapiens 195-205 1247285-1 1976 Three plasma fibrinogen methods are presented based on (1) clottable protein assay by Biuret reagent, (2) measurement of clot absorbance and (3) thrombin time. Biuret 86-92 fibrinogen beta chain Homo sapiens 13-23 1001743-0 1976 Effect of steric exclusion by dextran on the conversion of fibrinogen into fibrin. Dextrans 30-37 fibrinogen beta chain Homo sapiens 59-69 64398-1 1976 Description of a micromethod for determining heat fibrinogen where 0.06 to 0.08 ml of citrate plasma are only required. Citric Acid 86-93 fibrinogen beta chain Homo sapiens 50-60 950175-0 1976 Further studies of the interaction between ristocetin and fibrinogen. Ristocetin 43-53 fibrinogen beta chain Homo sapiens 58-68 950175-1 1976 Fibrinogen (FG) precipitation by ristocetin is enhanced by lowering the temperature to 4 degrees C. The precipitate has similar properties to an acquired cryofibrinogen being resolubilised on rewarming to 37 degrees C, and the process of precipitation and resolubilsation can be repeated indefinitely by lowering and raising the temperature. Ristocetin 33-43 fibrinogen beta chain Homo sapiens 0-10 950175-1 1976 Fibrinogen (FG) precipitation by ristocetin is enhanced by lowering the temperature to 4 degrees C. The precipitate has similar properties to an acquired cryofibrinogen being resolubilised on rewarming to 37 degrees C, and the process of precipitation and resolubilsation can be repeated indefinitely by lowering and raising the temperature. Ristocetin 33-43 fibrinogen beta chain Homo sapiens 12-14 966050-0 1976 Preparation and use of high specific activity 123I-labeled fibrinogen for deep veins thrombi imaging. Iodine-123 46-50 fibrinogen beta chain Homo sapiens 59-69 10637-1 1976 The reactivity of fibrinogen crosslinking sites with thrombin-free, preactivated factor XIII (F. XIIIa) was investigated under different conditions such as increased ionic strength, presence of urea, protamine sulfate (PS) or of varying concentrations of monodansylcadaverine (MDC). monodansylcadaverine 277-280 fibrinogen beta chain Homo sapiens 18-28 10637-3 1976 According to our results, rates of crosslinking of, and of MDC incorporation into, both gamma- and alpha-chains of fibrinogen were low under physiological conditions; they were not significantly influenced by the presence of either 1.0 M NaCl or 1.0 M urea. Urea 252-256 fibrinogen beta chain Homo sapiens 115-125 827734-2 1976 The method used is based upon the preferential adsorption of fibrinogen by barium sulfate at acid pH. Barium Sulfate 75-89 fibrinogen beta chain Homo sapiens 61-71 1004391-0 1976 [Clinical value and technics of diagnosis of deep vein thrombosis of the lower extremities by means of radioactive iodine-labeled fibrinogen]. radioactive iodine 103-121 fibrinogen beta chain Homo sapiens 130-140 827734-3 1976 After redissolution of the specific precipitate and dissociation of the antigen-antibody complexes at pH 2.4, the fibrinogen is removed by adsorption on barium sulfate, while the antibody protein stays in solution. Barium Sulfate 153-167 fibrinogen beta chain Homo sapiens 114-124 1251137-3 1976 Also at normal or high fibrinogen levels, a positive ethanol gelation test was more frequently associated with low thrombocyte counts, low factor V and Normotest/Thrombotest discrepancy than was a negative test. Ethanol 53-60 fibrinogen beta chain Homo sapiens 23-33 948779-0 1976 [Platelet and fibrinogen survival assay by SeM (selenium-methionine) (author"s transl)]. Selenomethionine 48-67 fibrinogen beta chain Homo sapiens 14-24 1258156-0 1976 [Anticlotting activity of fragment D from fibrinogen and fibrin and its dependence on calcium presence when fragments are obtained from fibrinogen]. Calcium 86-93 fibrinogen beta chain Homo sapiens 136-146 139704-0 1976 [Change in fibrinogen and enzymatic and nonenzymatic fibrinolytic activity of blood in patients with low-degree rheumatic heart disease under the effect of treatment with acetylsalicylic acid]. Aspirin 171-191 fibrinogen beta chain Homo sapiens 11-21 951840-6 1976 Fibrinogen, albumin and IgG were readily identified when adsorbed from a single protein solution onto teflon or silicone rubber. Silicones 112-120 fibrinogen beta chain Homo sapiens 0-10 951841-0 1976 Adsorption of albumin and fibrinogen to polyethylene in presence of red cells. Polyethylene 40-52 fibrinogen beta chain Homo sapiens 26-36 951870-10 1976 The 25 degrees C adsorption isotherms of fibrinogen obtained for both the glass and LTI-carbon powder adsorbents are not amenable to Langmuir type analysis but indicate multilayer sorption with a possible change in binding mechanism after the completion of the first sorbed monolayer. Carbon 88-94 fibrinogen beta chain Homo sapiens 41-51 1258156-1 1976 The CaCl2 concentration of about 10(-4) M slightly reduces the proteolytic fibrinogen degradation and greatly increases the anticlotting activity in the arising fragments D. With a rise in the CaCl2 concentration to 10(-2) M a subsequent limitation of proteolysis occurs, but less active fragments D are formed. Calcium Chloride 4-9 fibrinogen beta chain Homo sapiens 75-85 1258166-6 1976 An increase in the solution of the second class addition (glycol, glycerol, polyethylenglycol, glucose, surcrose) was followed by a decrease of tau, that indicates to an increase of trypophanyl availability, Such an interaction of additions with protein is typical of papain and fibrinogen. Glycols 58-64 fibrinogen beta chain Homo sapiens 279-289 1258166-6 1976 An increase in the solution of the second class addition (glycol, glycerol, polyethylenglycol, glucose, surcrose) was followed by a decrease of tau, that indicates to an increase of trypophanyl availability, Such an interaction of additions with protein is typical of papain and fibrinogen. polyethylenglycol 76-93 fibrinogen beta chain Homo sapiens 279-289 1258166-6 1976 An increase in the solution of the second class addition (glycol, glycerol, polyethylenglycol, glucose, surcrose) was followed by a decrease of tau, that indicates to an increase of trypophanyl availability, Such an interaction of additions with protein is typical of papain and fibrinogen. trypophanyl 182-193 fibrinogen beta chain Homo sapiens 279-289 1258166-6 1976 An increase in the solution of the second class addition (glycol, glycerol, polyethylenglycol, glucose, surcrose) was followed by a decrease of tau, that indicates to an increase of trypophanyl availability, Such an interaction of additions with protein is typical of papain and fibrinogen. surcrose 104-112 fibrinogen beta chain Homo sapiens 279-289 1215973-4 1975 125I-fibrinogen half-life was 2.1 days under aspirin and 1.9 days under combined aspirin/heparin therapy. Aspirin 45-52 fibrinogen beta chain Homo sapiens 5-15 1215973-4 1975 125I-fibrinogen half-life was 2.1 days under aspirin and 1.9 days under combined aspirin/heparin therapy. Aspirin 81-88 fibrinogen beta chain Homo sapiens 5-15 1215973-4 1975 125I-fibrinogen half-life was 2.1 days under aspirin and 1.9 days under combined aspirin/heparin therapy. Heparin 89-96 fibrinogen beta chain Homo sapiens 5-15 1191684-0 1975 The separation of S-carboxymethylated human fibrinogen chains with a single carboxymethyl-cellulose chromatography. Carboxymethylcellulose Sodium 76-99 fibrinogen beta chain Homo sapiens 44-54 1191680-5 1975 N-Acetylimidazole inhibited the activity towards fibrinogen, N-alphrosine-p-nitrophenyl ester to varying degrees. N-acetylimidazole 0-17 fibrinogen beta chain Homo sapiens 49-59 812201-0 1975 Cross-linking of human fibrinogen with glutaraldehyde and tetranitromethane. Glutaral 39-53 fibrinogen beta chain Homo sapiens 23-33 1239098-0 1975 The clot-forming ability of fibrinogen in solutions containing glucose and sorbitol. Glucose 63-70 fibrinogen beta chain Homo sapiens 28-38 812201-0 1975 Cross-linking of human fibrinogen with glutaraldehyde and tetranitromethane. Tetranitromethane 58-75 fibrinogen beta chain Homo sapiens 23-33 1239098-0 1975 The clot-forming ability of fibrinogen in solutions containing glucose and sorbitol. Sorbitol 75-83 fibrinogen beta chain Homo sapiens 28-38 1198460-0 1975 Proceedings: Role of trisodium citrate in the unclottability by thrombin of fibrinogen Metz. trisodium citrate 21-38 fibrinogen beta chain Homo sapiens 76-86 1198487-0 1975 Proceedings: Inhibition of ristocetin-induced platelet aggregation (RIPA) by Haemaccel and fibrinogen. Ristocetin 27-37 fibrinogen beta chain Homo sapiens 91-101 2590-1 1975 Carboxyl groups of native human fibrinogen were modified with glycine methyl ester and 1-ethyl-3(3-dimethylaminopropyl)carbodiimide. glycine methyl ester 62-82 fibrinogen beta chain Homo sapiens 32-42 2590-1 1975 Carboxyl groups of native human fibrinogen were modified with glycine methyl ester and 1-ethyl-3(3-dimethylaminopropyl)carbodiimide. Ethyldimethylaminopropyl Carbodiimide 87-131 fibrinogen beta chain Homo sapiens 32-42 1195668-5 1975 A specific role of the virus in this toxic syndrome can be demonstrated when heparin is employed to circumvent intravascular coagulation and fibrinogen loss. Heparin 77-84 fibrinogen beta chain Homo sapiens 141-151 1192601-1 1975 Polyacrylamide (PA) gel electrophoresis in sodium dodecyl sulphate (SDS) has been shown to distinguish between the major components in the plasmin induced lysates of purified crosslinked fibrin and fibrinogen. polyacrylamide 0-14 fibrinogen beta chain Homo sapiens 198-208 1192601-1 1975 Polyacrylamide (PA) gel electrophoresis in sodium dodecyl sulphate (SDS) has been shown to distinguish between the major components in the plasmin induced lysates of purified crosslinked fibrin and fibrinogen. polyacrylamide 16-18 fibrinogen beta chain Homo sapiens 198-208 1192601-1 1975 Polyacrylamide (PA) gel electrophoresis in sodium dodecyl sulphate (SDS) has been shown to distinguish between the major components in the plasmin induced lysates of purified crosslinked fibrin and fibrinogen. Sodium Dodecyl Sulfate 68-71 fibrinogen beta chain Homo sapiens 198-208 128845-0 1975 Enhanced anticlotting activity of fragments D formed during plasmin hydrolysis of fibrinogen in the presence of calcium chloride. Calcium Chloride 112-128 fibrinogen beta chain Homo sapiens 82-92 1209562-0 1975 Amino-terminal analysis of human fibrinogen treated with estrogenic steroids: failure to support a thrombin-mimetic proteolytic effect. Steroids 68-76 fibrinogen beta chain Homo sapiens 33-43 126094-1 1975 125I-fibrinogen, adsorbed to polystyrene tubes at low ionic strength and treated with thrombin, serves as a substrate for a rapid, convenient, and sensitive test tube assay for plasmin and activators and inhibitors of this enzyme. Polystyrenes 29-40 fibrinogen beta chain Homo sapiens 5-15 1176815-5 1975 SDS gel electrophoresis was utilized to show qualitatively that decreases in maximum clot elasticity, at constant fibrinogen concentration, are directly related to a decrease in Factor XIII-mediated intermolecular crosslinking. Sodium Dodecyl Sulfate 0-3 fibrinogen beta chain Homo sapiens 114-124 240516-4 1975 The amount of tyrosine liberated from the fibrinogen is measured and is related to activity. Tyrosine 14-22 fibrinogen beta chain Homo sapiens 42-52 1183792-5 1975 The number of cases of deep thrombophlebitis diagnosed by the I-125-Fibrinogen test was significantly less in the group receiving Heparin than in the group receiving Sintrom. Heparin 130-137 fibrinogen beta chain Homo sapiens 68-78 1183792-5 1975 The number of cases of deep thrombophlebitis diagnosed by the I-125-Fibrinogen test was significantly less in the group receiving Heparin than in the group receiving Sintrom. Acenocoumarol 166-173 fibrinogen beta chain Homo sapiens 68-78 1198062-0 1975 A positive ethanol gelation test associated with high plasma fibrinogen concentration - evidence for soluble fibrin. Ethanol 11-18 fibrinogen beta chain Homo sapiens 61-71 1198062-2 1975 By infusion of large amounts of human fibrinogen into rabbits, the ethanol gelation test turned positive at various plasma concentrations of fibrinogen, depending on the fibrinogen preparation used, and on individual differences among the animals. Ethanol 67-74 fibrinogen beta chain Homo sapiens 38-48 1198062-2 1975 By infusion of large amounts of human fibrinogen into rabbits, the ethanol gelation test turned positive at various plasma concentrations of fibrinogen, depending on the fibrinogen preparation used, and on individual differences among the animals. Ethanol 67-74 fibrinogen beta chain Homo sapiens 141-151 1198062-2 1975 By infusion of large amounts of human fibrinogen into rabbits, the ethanol gelation test turned positive at various plasma concentrations of fibrinogen, depending on the fibrinogen preparation used, and on individual differences among the animals. Ethanol 67-74 fibrinogen beta chain Homo sapiens 141-151 1198062-3 1975 After incubation of the fibrinogen preparation in the cold the precipitated material gave a positive ethanol gelation test at lower fibrinogen concentration whereas the ethanol gelation test remained negative in the supernatant at a higher fibrinogen level than that of the starting material. Ethanol 101-108 fibrinogen beta chain Homo sapiens 24-34 51664-2 1975 One hundred surgical patients were studied, and clinical examination and the iodine-125-labelled fibrinogen test used to assess the results. Iodine-125 77-87 fibrinogen beta chain Homo sapiens 97-107 1211467-4 1975 Addition of ADP to the platelet-fibrinogen mixture prior to BM enzyme resulted in stimulation of clot retraction that could be dissociated from the release of platelet constituents. Adenosine Diphosphate 12-15 fibrinogen beta chain Homo sapiens 32-42 1188318-0 1975 The amount of fibrin necessary to give a positive ethanol gelation test at various fibrinogen levels. Ethanol 50-57 fibrinogen beta chain Homo sapiens 83-93 1098506-1 1975 131I-labeled autologous fibrinogen was used to detect acute renal allograft rejection in the early postoperative period. Iodine-131 0-4 fibrinogen beta chain Homo sapiens 24-34 1149401-0 1975 Determination of platelet and fibrinogen half-life with [75Se]selenomethionine: studies in normal and in diabetic subjects. Selenomethionine 62-78 fibrinogen beta chain Homo sapiens 30-40 1088133-0 1976 A study of plasma fibrinogen level and plasma fibrinolytic activity in normal & abnormal pregnancy. Adenosine Monophosphate 79-82 fibrinogen beta chain Homo sapiens 18-28 126081-1 1975 Implications for the disulfide structure of fibrinogen. Disulfides 21-30 fibrinogen beta chain Homo sapiens 44-54 126081-8 1975 The data are compatible with a fibrinogen molecule in which the two halves are linked by a single locus of disulfide bonds at the amino terminus and with the asymmetric hypothesis of plasmic degradation to Fragments X, Y, D and E. Disulfides 107-116 fibrinogen beta chain Homo sapiens 31-41 125279-12 1975 248, 5806-5820); its NH2-terminal residue being Ala-63 of the gamma chain of fibrinogen. Alanine 48-51 fibrinogen beta chain Homo sapiens 77-87 125108-3 1975 A method is presented for detection of cross-linking acceptor sites on fibrinogen chains, using monodansyl-cadaverine labeling in the presence of activated fibrin stabilizing factor, and polyacrylamide electrophoresis in the presence of sodium dodecyl sulfate. monodansylcadaverine 96-117 fibrinogen beta chain Homo sapiens 71-81 125108-3 1975 A method is presented for detection of cross-linking acceptor sites on fibrinogen chains, using monodansyl-cadaverine labeling in the presence of activated fibrin stabilizing factor, and polyacrylamide electrophoresis in the presence of sodium dodecyl sulfate. Sodium Dodecyl Sulfate 237-259 fibrinogen beta chain Homo sapiens 71-81 125109-2 1975 Molecular model of the plasmin-resistant disulfide knot in monomeric fragment D. A mixture of fragments D, derived from fibrinogen by plasmic degradation, was S-reduced and carboxymethylated. Disulfides 41-50 fibrinogen beta chain Homo sapiens 120-130 1149268-1 1975 Methods for plasma fibrinogen based on thrombin time are technically simple, rapid, and sensitive, although "false low" results may occur due to heparin interference. Heparin 145-152 fibrinogen beta chain Homo sapiens 19-29 1147442-0 1975 Fibrinogen survival in cirrhosis: improvement by "low dose" heparin. Heparin 60-67 fibrinogen beta chain Homo sapiens 0-10 1147442-1 1975 The effect of "low dose" heparin therapy on fibrinogen survival in patients with cirrhosis was studied in six patients. Heparin 25-32 fibrinogen beta chain Homo sapiens 44-54 1147442-3 1975 Average fibrinogen half-life before heparin therapy was 52 hours and after 3000 units of intravenous heparin every 6 hours was 101.8 hours. Heparin 36-43 fibrinogen beta chain Homo sapiens 8-18 1147442-5 1975 In every instance fibrinogen survival was improved by heparin administration. Heparin 54-61 fibrinogen beta chain Homo sapiens 18-28 1147442-6 1975 These data indicate that "low dose" heparin improves fibrinogen survival in cirrhosis and suggest that disseminated intravascular coagulation is a primary process in the defibrination syndrome associated with cirrhosis. Heparin 36-43 fibrinogen beta chain Homo sapiens 53-63 1213264-3 1975 Fibrinogen and SFMC were precipitated from plasma by precipitation with beta-alanine. beta-Alanine 72-84 fibrinogen beta chain Homo sapiens 0-10 240916-2 1975 Fibrinogen containing 25, 50, and 100 atoms of iodine per molecule is prepared by an electrolytic procedure and is compared with conventional radiolabeled fibrinogen (less than 0.5 iodine atom per molecule) prepared by the iodine monochloride method. Iodine 47-53 fibrinogen beta chain Homo sapiens 0-10 1213264-4 1975 Gel filtration (4% agarose) of the redissolved precipitate resulted in a separation of SFMC and fibrinogen. Sepharose 19-26 fibrinogen beta chain Homo sapiens 96-106 1178516-0 1975 [99MTechnetium-fibrinogen labeling using electrolytic zircuronium release]. zircuronium 54-65 fibrinogen beta chain Homo sapiens 15-25 1216756-5 1975 But the fraction enriched in the ethanolamine phosphatides inhibited more distinctly the reaction between thrombin and fibrinogen. ethanolamine phosphatides 33-58 fibrinogen beta chain Homo sapiens 119-129 1178516-1 1975 An electrolytic method for labelling fibrinogen with zirconium as a reductant for 99mTc is presented. Zirconium 53-62 fibrinogen beta chain Homo sapiens 37-47 50744-6 1975 Although fibrinogen is required for ADP-induced primary aggregation, it does not support secondary aggregation and release, provided that it has no clot-promoting activity. Adenosine Diphosphate 36-39 fibrinogen beta chain Homo sapiens 9-19 806590-2 1975 Although human and bovine fibrinogen demonstrated three nonidentical polypeptide chains by sodium dodecyl sulfate gel separations and by CM-cellulose separations, rat fibrinogen Aalpha and Bbeta chains exhibited identical molecular weight sizes as well as identical charges. Cellulose 140-149 fibrinogen beta chain Homo sapiens 26-36 806590-4 1975 The gamma chain of rat fibrinogen was also shown to be quite distinct from the gamma chains of human and bovine fibrinogen in its elevated content of cysteinyl and methionyl residues. lysyl-cysteinyl-cysteinyl-arginyl-cysteinyl-lysine 150-159 fibrinogen beta chain Homo sapiens 23-33 806590-4 1975 The gamma chain of rat fibrinogen was also shown to be quite distinct from the gamma chains of human and bovine fibrinogen in its elevated content of cysteinyl and methionyl residues. methionyl 164-173 fibrinogen beta chain Homo sapiens 23-33 1138629-1 1975 Ankle systolic pressure measurements in 67 patients with intermittent claudication treated with Clofibrate for an average period of 11 months and 32 untreated patients suggest that 1) patients with a raised initial plasma fibrinogen concentration have more severe disease than those with low initial plasma fibrinogen concentration and 2) the response to treatment with Clofibrate is significantly better in those with a raised plasma fibrinogen concentration. Clofibrate 96-106 fibrinogen beta chain Homo sapiens 222-232 1138629-3 1975 There was also a significant decrease in mean plasma fibrinogen levels in the treated patients and it is suggested that the hypofibrinogenemic effect of Clofibrate may be responsible for the benefit of this drug in patients with vascular disease. Clofibrate 153-163 fibrinogen beta chain Homo sapiens 53-63 1133167-1 1975 The subunit structure of fibrinogen Baltimore and fibrin formed from this inherited dysfibrinogenemia was analyzed by polyacrylamide gel electrophoresis in sodium dodecyl sulfate. polyacrylamide 118-132 fibrinogen beta chain Homo sapiens 25-35 1169259-1 1975 Monovalent goat antibody fragments (Fab) that were monospecific for human fibrinogen were isolated by affinity chromatography on fibrinogen-Sepharose and used as a direct probe for the involvement of fibrinogen in platelet aggregation and the release reaction. Sepharose 140-149 fibrinogen beta chain Homo sapiens 129-139 1169259-1 1975 Monovalent goat antibody fragments (Fab) that were monospecific for human fibrinogen were isolated by affinity chromatography on fibrinogen-Sepharose and used as a direct probe for the involvement of fibrinogen in platelet aggregation and the release reaction. Sepharose 140-149 fibrinogen beta chain Homo sapiens 129-139 1215178-1 1975 In emergency traumatology, the iodine 125 labelled fibrinogen test is useful in the early detection of phlebitis in patients in whom the routine use of heparin is not possible--fractures of the cervical spine, severe cranial trauma, elderly subjects. Iodine 31-37 fibrinogen beta chain Homo sapiens 51-61 1215178-1 1975 In emergency traumatology, the iodine 125 labelled fibrinogen test is useful in the early detection of phlebitis in patients in whom the routine use of heparin is not possible--fractures of the cervical spine, severe cranial trauma, elderly subjects. Heparin 152-159 fibrinogen beta chain Homo sapiens 51-61 237576-3 1975 In an acid medium the fibrinogen molecule twice (in the pH range of 5--3 and 3--2) undergoes structural rearrangement. acid medium 6-17 fibrinogen beta chain Homo sapiens 22-32 1133167-1 1975 The subunit structure of fibrinogen Baltimore and fibrin formed from this inherited dysfibrinogenemia was analyzed by polyacrylamide gel electrophoresis in sodium dodecyl sulfate. Sodium Dodecyl Sulfate 156-178 fibrinogen beta chain Homo sapiens 25-35 1133167-8 1975 If clotting was carried out with calcium concentrations twice that required for normal clots or at pH 6.4, fibrin from fibrinogen Baltimore was completely cross-linked. Calcium 33-40 fibrinogen beta chain Homo sapiens 119-129 1120188-0 1975 Some factors affecting fibrinogen precipitation by ristocetin: ultrastructure of precipitates. Ristocetin 51-61 fibrinogen beta chain Homo sapiens 23-33 124474-3 1975 The dissociation constant of the FL-STI complex was determined to be 7 times 10-9 M. The average concentration of profibrinolysin in normal human citrated plasma was found to be 8 times 10-7 M. From the decrease of fibrinogen with time in the urokinase-treated plasma, the free fibrinolysin was calculated. fl-sti 33-39 fibrinogen beta chain Homo sapiens 215-225 1120188-1 1975 Fibrinogen in aqueous solution is precipitated by the antibiotic ristocetin. Ristocetin 65-75 fibrinogen beta chain Homo sapiens 0-10 1120188-4 1975 Ristocetin-precipitated fibrinogen takes the form of fibrils or clumps, composed of irregularly spaced, structure-less particles. Ristocetin 0-10 fibrinogen beta chain Homo sapiens 24-34 1120188-5 1975 The addition of ristocetin to washed platelets suspended in fibrinogen-containing media produces fibrinogen clumps in both the media and in the surface cannalicular system of the platelets. Ristocetin 16-26 fibrinogen beta chain Homo sapiens 60-70 1120188-5 1975 The addition of ristocetin to washed platelets suspended in fibrinogen-containing media produces fibrinogen clumps in both the media and in the surface cannalicular system of the platelets. Ristocetin 16-26 fibrinogen beta chain Homo sapiens 97-107 1120188-7 1975 The role of the latter is confirmed by the observation that the addition of ristocetin to inert latex particles suspended in fibrinogen solution produces typical aggregation curves. Ristocetin 76-86 fibrinogen beta chain Homo sapiens 125-135 1194984-4 1975 Technetium-99m-fibrinogen is stable in human plasma or in 1% buffered human serum albumin. Technetium 0-10 fibrinogen beta chain Homo sapiens 15-25 1194993-3 1975 Fibrinogen is isolated in two salting-out steps at a 1:4 dilution of plasma and 22.5% saturated ammonium sulfate. Ammonium Sulfate 96-112 fibrinogen beta chain Homo sapiens 0-10 1194995-3 1975 Separation of the desired product is achieved simply and efficiently using high-speed liquid chromatography or, in the case of fibrinogen, by ammonium sulfate precipitation. Ammonium Sulfate 142-158 fibrinogen beta chain Homo sapiens 127-137 124585-0 1975 Amino acid sequence of the carboxy-terminal cyanogen bromide peptide of the human fibrinogen beta-chain: homology with the corresponding gamma-chain peptide and presence in fragment D. The carboxy-terminal cyanogen bromide fragment of the human fibrinogen beta-chain has been isolated and its structure determined. Cyanogen Bromide 44-60 fibrinogen beta chain Homo sapiens 82-103 124585-0 1975 Amino acid sequence of the carboxy-terminal cyanogen bromide peptide of the human fibrinogen beta-chain: homology with the corresponding gamma-chain peptide and presence in fragment D. The carboxy-terminal cyanogen bromide fragment of the human fibrinogen beta-chain has been isolated and its structure determined. carboxy phosphate 27-34 fibrinogen beta chain Homo sapiens 82-103 124585-0 1975 Amino acid sequence of the carboxy-terminal cyanogen bromide peptide of the human fibrinogen beta-chain: homology with the corresponding gamma-chain peptide and presence in fragment D. The carboxy-terminal cyanogen bromide fragment of the human fibrinogen beta-chain has been isolated and its structure determined. terminal 35-43 fibrinogen beta chain Homo sapiens 82-103 124585-0 1975 Amino acid sequence of the carboxy-terminal cyanogen bromide peptide of the human fibrinogen beta-chain: homology with the corresponding gamma-chain peptide and presence in fragment D. The carboxy-terminal cyanogen bromide fragment of the human fibrinogen beta-chain has been isolated and its structure determined. Cyanogen Bromide 206-222 fibrinogen beta chain Homo sapiens 82-103 124585-0 1975 Amino acid sequence of the carboxy-terminal cyanogen bromide peptide of the human fibrinogen beta-chain: homology with the corresponding gamma-chain peptide and presence in fragment D. The carboxy-terminal cyanogen bromide fragment of the human fibrinogen beta-chain has been isolated and its structure determined. Cyanogen Bromide 206-222 fibrinogen beta chain Homo sapiens 245-266 49088-0 1975 Immunochemistry of the thrombin-altered NH2-terminal disulfide knot of human fibrinogen. Disulfides 53-62 fibrinogen beta chain Homo sapiens 77-87 236294-3 1975 In the interaction of fibrinogen with the cationic detergent, stearyltrimethyl-ammonium chloride, approximately 160 molecules of detergent were found to bind to one molecule of fibrinogen. stearyltrimethylammonium 62-96 fibrinogen beta chain Homo sapiens 22-32 236294-3 1975 In the interaction of fibrinogen with the cationic detergent, stearyltrimethyl-ammonium chloride, approximately 160 molecules of detergent were found to bind to one molecule of fibrinogen. stearyltrimethylammonium 62-96 fibrinogen beta chain Homo sapiens 177-187 236294-4 1975 In distilled water, the fibrinogen-stearyltrimethylammonium complex (FG-STA(Cl)) remained soluble in the presence of thrombin [ED 3.4.21.5] although the same peptides were released as those released from fibrinogen. Water 13-18 fibrinogen beta chain Homo sapiens 24-34 236294-4 1975 In distilled water, the fibrinogen-stearyltrimethylammonium complex (FG-STA(Cl)) remained soluble in the presence of thrombin [ED 3.4.21.5] although the same peptides were released as those released from fibrinogen. stearyltrimethylammonium 35-59 fibrinogen beta chain Homo sapiens 24-34 53064-2 1975 The area of thrombin inactivation is subsequently observed by the coagulation of fibrinogen in a separate agarose gel layer poured over the thrombin gel. Sepharose 106-113 fibrinogen beta chain Homo sapiens 81-91 1138426-6 1975 The fibrinogen level was increased in the first month of oral contraceptive use in the three groups but after several months of use the pattern of change seen in the first month was repeated with the lower estrogen compounds, but in the group using the preparation with 100 mu-g Mestranol, the fibrinogen level returned to that of the control month. Mestranol 279-288 fibrinogen beta chain Homo sapiens 4-14 810399-1 1975 Human fibrinogen was adsorbed on thrombin-activated fibrinogen which had been immobilized by covalent coupling with Sepharose-6B (Fibrin-Sepharose). sepharose-6b 116-128 fibrinogen beta chain Homo sapiens 6-16 810399-1 1975 Human fibrinogen was adsorbed on thrombin-activated fibrinogen which had been immobilized by covalent coupling with Sepharose-6B (Fibrin-Sepharose). sepharose-6b 116-128 fibrinogen beta chain Homo sapiens 52-62 810399-1 1975 Human fibrinogen was adsorbed on thrombin-activated fibrinogen which had been immobilized by covalent coupling with Sepharose-6B (Fibrin-Sepharose). Sepharose 116-125 fibrinogen beta chain Homo sapiens 6-16 810399-1 1975 Human fibrinogen was adsorbed on thrombin-activated fibrinogen which had been immobilized by covalent coupling with Sepharose-6B (Fibrin-Sepharose). Sepharose 116-125 fibrinogen beta chain Homo sapiens 52-62 810399-8 1975 In subsequent fractions, fibrinogen was associated with another protein which, in dodecylsulfate gel electrophoresis, migrated with a rate similar to that of the gamma-chains. dodecyl sulfate 82-96 fibrinogen beta chain Homo sapiens 25-35 1173027-1 1975 It has been shown that a variety of synthetic organic anions which induce fibrinolytic activity in human plasma in vitro and which in addition inhibit collagen-induced aggregation of human platelets, also exert to various degrees an inhibition of dextran, fibrinogen and gelatin induced aggregation of human erythrocytes and of the pathologically accelerated erythrocyte sedimentation rate. Dextrans 247-254 fibrinogen beta chain Homo sapiens 256-266 1114483-0 1975 Estrogen induced appearance of N-terminal glycine from chromatographically purified fibrinogen. Glycine 42-49 fibrinogen beta chain Homo sapiens 84-94 1233188-5 1975 On the other hand, the fibrinogen radioactivity was increased in 4 patients (12%) of the Calciparin group. calcium heparin 89-99 fibrinogen beta chain Homo sapiens 23-33 1061481-0 1975 The use of 125I-labelled fibrinogen for determination of fibrin trapping in the lungs in patients developing the microembolism syndrome. Iodine-125 11-15 fibrinogen beta chain Homo sapiens 25-35 1090209-1 1975 Fibrinogen content was determined for each of 50 units of citrate-dextrose-phosphate (CPD)-preserved whole blood, packed red blood cells reconstituted with 250 ml. citrate-dextrose-phosphate 58-84 fibrinogen beta chain Homo sapiens 0-10 1225326-6 1975 Heparin treatment was successful: haemorrhages stopped already 24 hours later, while an increase of fibrinogen concentration and number of platelets in blood proceeded at slower rate. Heparin 0-7 fibrinogen beta chain Homo sapiens 100-110 51701-3 1975 The second, detectable with anti-membrane antiserum after absorption with fibrinogen remained with the fibrinogen-like antigen during isoelectric precipitation at pH 4.7, electrophoresis at pH 8.6 and chromatography on DEAE cellulose. DEAE-Cellulose 219-233 fibrinogen beta chain Homo sapiens 74-84 51701-3 1975 The second, detectable with anti-membrane antiserum after absorption with fibrinogen remained with the fibrinogen-like antigen during isoelectric precipitation at pH 4.7, electrophoresis at pH 8.6 and chromatography on DEAE cellulose. DEAE-Cellulose 219-233 fibrinogen beta chain Homo sapiens 103-113 54319-0 1975 Bovine fibrinogen-induced 14C-serotonin and other compounds release from human blood platelets. Carbon-14 26-29 fibrinogen beta chain Homo sapiens 7-17 54319-0 1975 Bovine fibrinogen-induced 14C-serotonin and other compounds release from human blood platelets. Serotonin 30-39 fibrinogen beta chain Homo sapiens 7-17 54319-1 1975 Bovine fibrinogen can aggregate human blood platelets by a direct mechanism (first wave) and also indirectly by releasing endogenous ADP (second wave). Adenosine Diphosphate 133-136 fibrinogen beta chain Homo sapiens 7-17 54319-5 1975 The changes induced by bovine fibrinogen thus follows the same pattern as the irreversible phase of aggregation, linked to release as induced by ADP. Adenosine Diphosphate 145-148 fibrinogen beta chain Homo sapiens 30-40 1090656-4 1975 Classic delayed hypersensitivity (DH) reactions to Old Tuberculin and to the azobenzenearsonate hapten were characterized by a progressive increase in the fibrinogen (125-I-HF) content which exceeded that of the albumin tracer (131-I-HSA) and paralleled the development of induration and erythema. p-Azobenzenearsonate 77-95 fibrinogen beta chain Homo sapiens 155-165 1119113-1 1975 An effect of increase in fibrinolytic activity of adrenaline-heparin (ADH) complex was studied under its incubation in a mixture with pure fibrinogen on unstablized plates of fibrin in presence of xi-aminocapronic acid, By means of spectrophotometry in UV-light an increase in lytic activity of the incubated mixture of adrenaline-heparin complex with fibrinogen was shown to be due to formation of a secondary complex, which included adrenaline, heparin and fibrinogen. adrenaline-heparin 50-68 fibrinogen beta chain Homo sapiens 139-149 1119113-1 1975 An effect of increase in fibrinolytic activity of adrenaline-heparin (ADH) complex was studied under its incubation in a mixture with pure fibrinogen on unstablized plates of fibrin in presence of xi-aminocapronic acid, By means of spectrophotometry in UV-light an increase in lytic activity of the incubated mixture of adrenaline-heparin complex with fibrinogen was shown to be due to formation of a secondary complex, which included adrenaline, heparin and fibrinogen. adrenaline-heparin 50-68 fibrinogen beta chain Homo sapiens 352-362 4462754-0 1974 The solubility of fibrinogen in solutions containing dextrans of various molecular weights. Dextrans 53-61 fibrinogen beta chain Homo sapiens 18-28 4462754-1 1974 The effect of dextrans of various molecular weights on the solubility of fibrinogen was investigated. Dextrans 14-22 fibrinogen beta chain Homo sapiens 73-83 1119113-1 1975 An effect of increase in fibrinolytic activity of adrenaline-heparin (ADH) complex was studied under its incubation in a mixture with pure fibrinogen on unstablized plates of fibrin in presence of xi-aminocapronic acid, By means of spectrophotometry in UV-light an increase in lytic activity of the incubated mixture of adrenaline-heparin complex with fibrinogen was shown to be due to formation of a secondary complex, which included adrenaline, heparin and fibrinogen. adrenaline-heparin 50-68 fibrinogen beta chain Homo sapiens 352-362 1119113-1 1975 An effect of increase in fibrinolytic activity of adrenaline-heparin (ADH) complex was studied under its incubation in a mixture with pure fibrinogen on unstablized plates of fibrin in presence of xi-aminocapronic acid, By means of spectrophotometry in UV-light an increase in lytic activity of the incubated mixture of adrenaline-heparin complex with fibrinogen was shown to be due to formation of a secondary complex, which included adrenaline, heparin and fibrinogen. adh 70-73 fibrinogen beta chain Homo sapiens 139-149 1119113-1 1975 An effect of increase in fibrinolytic activity of adrenaline-heparin (ADH) complex was studied under its incubation in a mixture with pure fibrinogen on unstablized plates of fibrin in presence of xi-aminocapronic acid, By means of spectrophotometry in UV-light an increase in lytic activity of the incubated mixture of adrenaline-heparin complex with fibrinogen was shown to be due to formation of a secondary complex, which included adrenaline, heparin and fibrinogen. adh 70-73 fibrinogen beta chain Homo sapiens 352-362 1119113-1 1975 An effect of increase in fibrinolytic activity of adrenaline-heparin (ADH) complex was studied under its incubation in a mixture with pure fibrinogen on unstablized plates of fibrin in presence of xi-aminocapronic acid, By means of spectrophotometry in UV-light an increase in lytic activity of the incubated mixture of adrenaline-heparin complex with fibrinogen was shown to be due to formation of a secondary complex, which included adrenaline, heparin and fibrinogen. adh 70-73 fibrinogen beta chain Homo sapiens 352-362 1119113-1 1975 An effect of increase in fibrinolytic activity of adrenaline-heparin (ADH) complex was studied under its incubation in a mixture with pure fibrinogen on unstablized plates of fibrin in presence of xi-aminocapronic acid, By means of spectrophotometry in UV-light an increase in lytic activity of the incubated mixture of adrenaline-heparin complex with fibrinogen was shown to be due to formation of a secondary complex, which included adrenaline, heparin and fibrinogen. Epinephrine 50-60 fibrinogen beta chain Homo sapiens 139-149 1119113-1 1975 An effect of increase in fibrinolytic activity of adrenaline-heparin (ADH) complex was studied under its incubation in a mixture with pure fibrinogen on unstablized plates of fibrin in presence of xi-aminocapronic acid, By means of spectrophotometry in UV-light an increase in lytic activity of the incubated mixture of adrenaline-heparin complex with fibrinogen was shown to be due to formation of a secondary complex, which included adrenaline, heparin and fibrinogen. Epinephrine 50-60 fibrinogen beta chain Homo sapiens 352-362 1119113-1 1975 An effect of increase in fibrinolytic activity of adrenaline-heparin (ADH) complex was studied under its incubation in a mixture with pure fibrinogen on unstablized plates of fibrin in presence of xi-aminocapronic acid, By means of spectrophotometry in UV-light an increase in lytic activity of the incubated mixture of adrenaline-heparin complex with fibrinogen was shown to be due to formation of a secondary complex, which included adrenaline, heparin and fibrinogen. Epinephrine 50-60 fibrinogen beta chain Homo sapiens 352-362 1119113-1 1975 An effect of increase in fibrinolytic activity of adrenaline-heparin (ADH) complex was studied under its incubation in a mixture with pure fibrinogen on unstablized plates of fibrin in presence of xi-aminocapronic acid, By means of spectrophotometry in UV-light an increase in lytic activity of the incubated mixture of adrenaline-heparin complex with fibrinogen was shown to be due to formation of a secondary complex, which included adrenaline, heparin and fibrinogen. Heparin 61-68 fibrinogen beta chain Homo sapiens 139-149 4610046-0 1974 Requirement for complement components and fibrinogen in the zymosan-induced release reaction of human blood platelets. Zymosan 60-67 fibrinogen beta chain Homo sapiens 42-52 1119113-1 1975 An effect of increase in fibrinolytic activity of adrenaline-heparin (ADH) complex was studied under its incubation in a mixture with pure fibrinogen on unstablized plates of fibrin in presence of xi-aminocapronic acid, By means of spectrophotometry in UV-light an increase in lytic activity of the incubated mixture of adrenaline-heparin complex with fibrinogen was shown to be due to formation of a secondary complex, which included adrenaline, heparin and fibrinogen. Heparin 61-68 fibrinogen beta chain Homo sapiens 352-362 1119113-1 1975 An effect of increase in fibrinolytic activity of adrenaline-heparin (ADH) complex was studied under its incubation in a mixture with pure fibrinogen on unstablized plates of fibrin in presence of xi-aminocapronic acid, By means of spectrophotometry in UV-light an increase in lytic activity of the incubated mixture of adrenaline-heparin complex with fibrinogen was shown to be due to formation of a secondary complex, which included adrenaline, heparin and fibrinogen. Heparin 61-68 fibrinogen beta chain Homo sapiens 352-362 1119113-2 1975 After intravenous administration of a mixture of ADH complex with fibrinogen, containing products of interaction of adrenaline, heparin and fibrinogen, not only an increase in non-enzymic fibrinolytic activity of plasma occurred, but also an increase in duration of an effect of adrenaline--heparin--fibrinogen complex was observed in vivo as compared with the equivalent dose of the ADH complex adh 49-52 fibrinogen beta chain Homo sapiens 66-76 1119113-2 1975 After intravenous administration of a mixture of ADH complex with fibrinogen, containing products of interaction of adrenaline, heparin and fibrinogen, not only an increase in non-enzymic fibrinolytic activity of plasma occurred, but also an increase in duration of an effect of adrenaline--heparin--fibrinogen complex was observed in vivo as compared with the equivalent dose of the ADH complex adh 49-52 fibrinogen beta chain Homo sapiens 140-150 1119113-2 1975 After intravenous administration of a mixture of ADH complex with fibrinogen, containing products of interaction of adrenaline, heparin and fibrinogen, not only an increase in non-enzymic fibrinolytic activity of plasma occurred, but also an increase in duration of an effect of adrenaline--heparin--fibrinogen complex was observed in vivo as compared with the equivalent dose of the ADH complex adh 49-52 fibrinogen beta chain Homo sapiens 140-150 1119113-2 1975 After intravenous administration of a mixture of ADH complex with fibrinogen, containing products of interaction of adrenaline, heparin and fibrinogen, not only an increase in non-enzymic fibrinolytic activity of plasma occurred, but also an increase in duration of an effect of adrenaline--heparin--fibrinogen complex was observed in vivo as compared with the equivalent dose of the ADH complex Epinephrine 116-126 fibrinogen beta chain Homo sapiens 66-76 4458424-0 1974 Hyperthyroidism induced by potassium iodide given in the course of 125I-fibrinogen test. Potassium Iodide 27-43 fibrinogen beta chain Homo sapiens 72-82 1119113-2 1975 After intravenous administration of a mixture of ADH complex with fibrinogen, containing products of interaction of adrenaline, heparin and fibrinogen, not only an increase in non-enzymic fibrinolytic activity of plasma occurred, but also an increase in duration of an effect of adrenaline--heparin--fibrinogen complex was observed in vivo as compared with the equivalent dose of the ADH complex adh 384-387 fibrinogen beta chain Homo sapiens 66-76 4458424-1 1974 Hyperthyroidism developed in three patients during the administration of potassium iodide given for the purpose of blocking the thyroid uptake of radioactive iodine liberated in the course of the 125I-fibrinogen test. Potassium Iodide 73-89 fibrinogen beta chain Homo sapiens 201-211 4458424-1 1974 Hyperthyroidism developed in three patients during the administration of potassium iodide given for the purpose of blocking the thyroid uptake of radioactive iodine liberated in the course of the 125I-fibrinogen test. radioactive iodine 146-164 fibrinogen beta chain Homo sapiens 201-211 4458424-5 1974 It is suggested that for the performance of the 125I-fibrinogen test potassium iodide need not be given to the elderly and should be given in a dose of 30 mg daily for two weeks to younger patients. Potassium Iodide 69-85 fibrinogen beta chain Homo sapiens 53-63 1119113-2 1975 After intravenous administration of a mixture of ADH complex with fibrinogen, containing products of interaction of adrenaline, heparin and fibrinogen, not only an increase in non-enzymic fibrinolytic activity of plasma occurred, but also an increase in duration of an effect of adrenaline--heparin--fibrinogen complex was observed in vivo as compared with the equivalent dose of the ADH complex adh 384-387 fibrinogen beta chain Homo sapiens 140-150 1119113-2 1975 After intravenous administration of a mixture of ADH complex with fibrinogen, containing products of interaction of adrenaline, heparin and fibrinogen, not only an increase in non-enzymic fibrinolytic activity of plasma occurred, but also an increase in duration of an effect of adrenaline--heparin--fibrinogen complex was observed in vivo as compared with the equivalent dose of the ADH complex adh 384-387 fibrinogen beta chain Homo sapiens 140-150 4278309-0 1974 The distribution of carbohydrate in the plasmin resistant core fragments (D,E) of human fibrinogen. Carbohydrates 20-32 fibrinogen beta chain Homo sapiens 88-98 4853767-1 1974 In a series of patients given hydroxychloroquine sulphate by mouth before and after major surgery the incidence of deep venous thrombosis in the legs, as assessed by iodine-125-tagged fibrinogen scanning and venography, was reduced to 5% compared with an incidence of 16% in a similar untreated group of patients. Hydroxychloroquine 30-57 fibrinogen beta chain Homo sapiens 184-194 4472114-0 1974 Fibrin degradation products and the 125I-labeled fibrinogen test in patients with myocardial infarction. Iodine-125 36-40 fibrinogen beta chain Homo sapiens 49-59 4216122-0 1974 Characterization of the venoms of various Bothrops species by immunoelectrophoresis and reaction with fibrinogen agarose. Sepharose 113-120 fibrinogen beta chain Homo sapiens 102-112 4821857-0 1974 Effect of cyanate on clottability of fibrinogen. Cyanates 10-17 fibrinogen beta chain Homo sapiens 37-47 4844064-0 1974 Characterization of fibrinogen and fibrin degradation products by isoelectric focusing in polyacrylamide gel. polyacrylamide 90-104 fibrinogen beta chain Homo sapiens 20-30 4858454-0 1974 Polyethylene glycol 6,000 enhancement of the clotting of fibrinogen solutions in visual and mechanical assays. polyethylene glycol 6 0-21 fibrinogen beta chain Homo sapiens 57-67 4856883-6 1974 The abnormally long thrombin time of fibrinogen Cleveland II was partially corrected by addition of calcium ions. Calcium 100-107 fibrinogen beta chain Homo sapiens 37-47 4856883-7 1974 Fibrinogen Cleveland II was indistinguishable from normal fibrinogen by immunoelectrophoresis, DEAE-cellulose column chromatography, or polyacrylamide gel electrophoresis of reduced fibrinogen in sodium dodecyl sulfate. Sodium Dodecyl Sulfate 196-218 fibrinogen beta chain Homo sapiens 0-10 4856883-7 1974 Fibrinogen Cleveland II was indistinguishable from normal fibrinogen by immunoelectrophoresis, DEAE-cellulose column chromatography, or polyacrylamide gel electrophoresis of reduced fibrinogen in sodium dodecyl sulfate. Sodium Dodecyl Sulfate 196-218 fibrinogen beta chain Homo sapiens 182-192 4839054-0 1974 The solubility of fibrinogen in dilute salt solutions. Salts 39-43 fibrinogen beta chain Homo sapiens 18-28 4427304-1 1974 Preliminary trial of iodine 131 labelled fibrinogen (author"s transl)]. Iodine-131 21-31 fibrinogen beta chain Homo sapiens 41-51 4807801-0 1973 Dissociation of fibrinogen and fibrin peptide chains by partial cleavage of disulfide bonds. Disulfides 76-85 fibrinogen beta chain Homo sapiens 16-26 4761825-0 1973 The determination of optimum glycine concentration for the perparation of human fibrinogen at ambient temperatures. Glycine 29-36 fibrinogen beta chain Homo sapiens 80-90 4712046-0 1973 [Plasma fibrinogen levels in prolonged administration of various doses of hydrocortisone]. Hydrocortisone 74-88 fibrinogen beta chain Homo sapiens 8-18 4266974-0 1973 Characterisation of large fragments rich in disulphide bridges from CNBr-treated products of exhaustive proteolysis of fibrinogen by plasmin. disulphide 44-54 fibrinogen beta chain Homo sapiens 119-129 4266974-0 1973 Characterisation of large fragments rich in disulphide bridges from CNBr-treated products of exhaustive proteolysis of fibrinogen by plasmin. Cyanogen Bromide 68-72 fibrinogen beta chain Homo sapiens 119-129 4216114-0 1973 [Identification and preparation of high-molecular derivatives of fibrinogen from human plasma by means of PAA-gel electrophoresis and agarose-gel chromatography]. Sepharose 134-141 fibrinogen beta chain Homo sapiens 65-75 4773419-0 1973 [Effect of epsilon-aminocaproic acid on the accumulation of labeled fibrinogen I-131 in the transplantable tumor IMP-1]. Aminocaproic Acid 11-36 fibrinogen beta chain Homo sapiens 68-78 4675597-0 1972 [Malignant tumor scintigraphy using 131-I-labelled fibrinogen]. Iodine-131 36-41 fibrinogen beta chain Homo sapiens 51-61 5065312-0 1972 Influence of organically bound phosphorus in foetal and adult fibrinogen on the kinetics of the interaction between thrombin and fibrinogen. Phosphorus 31-41 fibrinogen beta chain Homo sapiens 62-72 5065312-0 1972 Influence of organically bound phosphorus in foetal and adult fibrinogen on the kinetics of the interaction between thrombin and fibrinogen. Phosphorus 31-41 fibrinogen beta chain Homo sapiens 129-139 5046146-8 1972 Dextran was found to act indirectly on the erythrocyte flexibility by reducing the plasma fibrinogen concentration. Dextrans 0-7 fibrinogen beta chain Homo sapiens 90-100 5012319-1 1972 I. Clevage of fibrinogen with cyanogen bromide. Cyanogen Bromide 30-46 fibrinogen beta chain Homo sapiens 14-24 236294-4 1975 In distilled water, the fibrinogen-stearyltrimethylammonium complex (FG-STA(Cl)) remained soluble in the presence of thrombin [ED 3.4.21.5] although the same peptides were released as those released from fibrinogen. stearyltrimethylammonium 35-59 fibrinogen beta chain Homo sapiens 204-214 805129-1 1975 Stearyltrimethylammonium chloride was used to isolate human fibrinogen, and purified protein was obtained by removing the detergent bound to it. stearyltrimethylammonium 0-33 fibrinogen beta chain Homo sapiens 60-70 11344575-4 1974 The thrombin time of plasma or purified fibrinogen was prolonged and only partially corrected by the addition of calcium. Calcium 113-120 fibrinogen beta chain Homo sapiens 40-50 11344575-8 1974 Acrylamide gel electrophoresis of mixtures of [121I]normal and [125I]abnormal fibrinogens revealed a slight increase in the anodal mobility of fibrinogen Philadelphia. Acrylamide 0-10 fibrinogen beta chain Homo sapiens 78-88 4202821-0 1973 Identification of a large fragment after limited cyanogen bromide cleavage of fibrinogen. Cyanogen Bromide 49-65 fibrinogen beta chain Homo sapiens 78-88 4719177-0 1973 A study of intravascular coagulation in immune complex glomerulonephritis by use of 131-I-labelled fibrinogen and 125I-labelled antigen. Iodine-131 84-89 fibrinogen beta chain Homo sapiens 99-109 4710254-0 1973 Copper ion binding and heparin interactions of human fibrinogen. Copper 0-6 fibrinogen beta chain Homo sapiens 53-63 4740135-0 1973 [Metabolism of fibrinogen following administration of brain phospholipids in combination with an antifibrinolytic agent (AMCHA)]. Phospholipids 60-73 fibrinogen beta chain Homo sapiens 15-25 4780710-0 1973 [Formation of a fibrinogen-heparin complex in the presence of interaction of an adrenaline-heparin complex with fibrinogen in vitro and in vivo]. Heparin 27-34 fibrinogen beta chain Homo sapiens 16-26 4780710-0 1973 [Formation of a fibrinogen-heparin complex in the presence of interaction of an adrenaline-heparin complex with fibrinogen in vitro and in vivo]. Heparin 27-34 fibrinogen beta chain Homo sapiens 112-122 4780710-0 1973 [Formation of a fibrinogen-heparin complex in the presence of interaction of an adrenaline-heparin complex with fibrinogen in vitro and in vivo]. Epinephrine 80-90 fibrinogen beta chain Homo sapiens 16-26 4780710-0 1973 [Formation of a fibrinogen-heparin complex in the presence of interaction of an adrenaline-heparin complex with fibrinogen in vitro and in vivo]. Epinephrine 80-90 fibrinogen beta chain Homo sapiens 112-122 4780710-0 1973 [Formation of a fibrinogen-heparin complex in the presence of interaction of an adrenaline-heparin complex with fibrinogen in vitro and in vivo]. Heparin 91-98 fibrinogen beta chain Homo sapiens 16-26 4780710-0 1973 [Formation of a fibrinogen-heparin complex in the presence of interaction of an adrenaline-heparin complex with fibrinogen in vitro and in vivo]. Heparin 91-98 fibrinogen beta chain Homo sapiens 112-122 11946783-0 1972 Amino acid sequence of the carboxy-terminal cyanogen bromide fragment from bovine and human fibrinogen gamma-chains. Cyanogen Bromide 44-60 fibrinogen beta chain Homo sapiens 92-102 5054252-4 1972 Thus, fibrinogen was not an essential factor for the interaction, though it may facilitate the rate of clumping produced by polybrene or polylysine. Hexadimethrine Bromide 124-133 fibrinogen beta chain Homo sapiens 6-16 5054252-4 1972 Thus, fibrinogen was not an essential factor for the interaction, though it may facilitate the rate of clumping produced by polybrene or polylysine. Polylysine 137-147 fibrinogen beta chain Homo sapiens 6-16 5040753-0 1972 Effect of heparin on radio fibrinogen catabolism in renal disease. Heparin 10-17 fibrinogen beta chain Homo sapiens 27-37 5032097-0 1972 Platelet and fibrinogen kinetics with ( 75 Se)selenomethionine in thrombocytopenic states. Selenomethionine 46-62 fibrinogen beta chain Homo sapiens 13-23 5022796-0 1972 Effect of 4-aminomethylcyclohexanecarboxylic acid on fibrinogen turnover. Tranexamic Acid 10-49 fibrinogen beta chain Homo sapiens 53-63 4622105-7 1972 In contrast to fibrinogen St. Louis, the most similar other fibrinogen variant (fibrinogen Zurich) was found to be heterogeneous by several criteria and to have reduced hexose content. Hexoses 169-175 fibrinogen beta chain Homo sapiens 60-70 4622105-7 1972 In contrast to fibrinogen St. Louis, the most similar other fibrinogen variant (fibrinogen Zurich) was found to be heterogeneous by several criteria and to have reduced hexose content. Hexoses 169-175 fibrinogen beta chain Homo sapiens 60-70 5010760-0 1972 [Effect of vitamin A on the level of seromucoid and fibrinogen and the activity of muramidase in the serum of patients with bronchial asthma]. Vitamin A 11-20 fibrinogen beta chain Homo sapiens 52-62 4500669-0 1972 Platelet and fibrinogen kinetics with ( 75 Se)-selenomethionine in patients with myeloproliferative disorders. ( 75 se)-selenomethionine 38-63 fibrinogen beta chain Homo sapiens 13-23 5009823-0 1972 Molecular weight analysis of fibrinogen and fibrin chains by an improved sodium dodecyl sulfate gel electrophoresis method. Sodium Dodecyl Sulfate 73-95 fibrinogen beta chain Homo sapiens 29-39 5096509-4 1971 The addition of 0.03 NIH U/ml of thrombin to normal human plasma resulted in a two to threefold increase in the incorporation of GEE-(14)C into the fibrinogen. glycine ethyl ester 129-132 fibrinogen beta chain Homo sapiens 148-158 5118165-0 1971 Fibrinogen assay during heparin therapy of disseminated intravascular coagulation. Heparin 24-31 fibrinogen beta chain Homo sapiens 0-10 11452384-2 1971 The C-terminal ends of bovine fibrinogen and fibrin were identified as proline and valine, in the molar ratio of approximately 1:2. Proline 71-78 fibrinogen beta chain Homo sapiens 30-40 11452384-2 1971 The C-terminal ends of bovine fibrinogen and fibrin were identified as proline and valine, in the molar ratio of approximately 1:2. Valine 83-89 fibrinogen beta chain Homo sapiens 30-40 11452384-4 1971 On hydrazinolysis after selective tritium labelling of fibrinogen, radioactive C-terminal valine was also identified. Tritium 34-41 fibrinogen beta chain Homo sapiens 55-65 11452384-4 1971 On hydrazinolysis after selective tritium labelling of fibrinogen, radioactive C-terminal valine was also identified. Valine 90-96 fibrinogen beta chain Homo sapiens 55-65 5564392-12 1971 Formation of fibrinogen degradation products was monitored by SDS-polyacrylamide gel electrophoresis of the corresponding fibrins after reduction of disulfide bonds (a method capable of distinguishing alpha-, beta- and gamma-chains). Sodium Dodecyl Sulfate 62-65 fibrinogen beta chain Homo sapiens 13-23 11452384-9 1971 It should be noted that hydrophobic amino acids, like isoleucine, valine and proline, are mainly located in the C-terminal ends of all three chain peptides in the fibrinogen molecule. Isoleucine 54-64 fibrinogen beta chain Homo sapiens 163-173 11452384-9 1971 It should be noted that hydrophobic amino acids, like isoleucine, valine and proline, are mainly located in the C-terminal ends of all three chain peptides in the fibrinogen molecule. Valine 66-72 fibrinogen beta chain Homo sapiens 163-173 11452384-9 1971 It should be noted that hydrophobic amino acids, like isoleucine, valine and proline, are mainly located in the C-terminal ends of all three chain peptides in the fibrinogen molecule. Proline 77-84 fibrinogen beta chain Homo sapiens 163-173 5564392-12 1971 Formation of fibrinogen degradation products was monitored by SDS-polyacrylamide gel electrophoresis of the corresponding fibrins after reduction of disulfide bonds (a method capable of distinguishing alpha-, beta- and gamma-chains). polyacrylamide 66-80 fibrinogen beta chain Homo sapiens 13-23 5564392-12 1971 Formation of fibrinogen degradation products was monitored by SDS-polyacrylamide gel electrophoresis of the corresponding fibrins after reduction of disulfide bonds (a method capable of distinguishing alpha-, beta- and gamma-chains). Disulfides 149-158 fibrinogen beta chain Homo sapiens 13-23 5564395-5 1971 The morphologic appearance of fibrin strands formed from fibrinogen Baltimore by thrombin at pH 7.4 was abnormal when examined by phase contrast or electron microscopy, but those formed by thrombin at pH 6.4 or by thrombin and calcium chloride were similar to, though less compact, than normal fibrin. Calcium Chloride 227-243 fibrinogen beta chain Homo sapiens 57-67 4327023-1 1971 I. Competetive adsorption of fibrinogen and heparin on mica. mica 55-59 fibrinogen beta chain Homo sapiens 29-39 5163179-1 1971 The metabolism of human fibrinogen labeled with radioactive iodine was studied in 50 patients with documented cirrhosis of the liver and in 35 healthy control subjects. radioactive iodine 48-66 fibrinogen beta chain Homo sapiens 24-34 5090065-1 1971 The formation of human fibrin from fibrinogen has been examined by polyacrylamide gel electrophoresis in sodium dodecyl sulfate, a method which separates a mixture of proteins on the basis of differences in molecular weight. polyacrylamide 67-81 fibrinogen beta chain Homo sapiens 35-45 5109508-0 1971 Fibrinogen turnover during the treatment with xantinol nicotinate. Xanthinol Niacinate 46-65 fibrinogen beta chain Homo sapiens 0-10 5090065-1 1971 The formation of human fibrin from fibrinogen has been examined by polyacrylamide gel electrophoresis in sodium dodecyl sulfate, a method which separates a mixture of proteins on the basis of differences in molecular weight. Sodium Dodecyl Sulfate 105-127 fibrinogen beta chain Homo sapiens 35-45 5090065-6 1971 This method depends upon the use of urea-treated fibrinogen, which is completely devoid of fibrin-stabilizing factor, but which forms the usual cross-linked subunits after conversion to fibrin by thrombin in the presence of fibrin-stabilizing factor. Urea 36-40 fibrinogen beta chain Homo sapiens 49-59 5093906-0 1971 [Phosphate and hexose content of fetal fibrinogen]. Phosphates 1-10 fibrinogen beta chain Homo sapiens 39-49 5093906-0 1971 [Phosphate and hexose content of fetal fibrinogen]. Hexoses 15-21 fibrinogen beta chain Homo sapiens 39-49 5314853-2 1971 Thrombin clottable fibrinogen estimates in the presence of epsilon amino caproic acid, fibrinogen and fibrin degradation products. Aminocaproic Acid 59-85 fibrinogen beta chain Homo sapiens 19-29 5280988-0 1971 Fibrinogen survival with [75Se]Selenomethionine during L-asparaginase therapy. Selenomethionine 31-47 fibrinogen beta chain Homo sapiens 0-10 5099019-0 1971 The isolation of fibrinogen with mercury complexes and their interaction. Mercury 33-40 fibrinogen beta chain Homo sapiens 17-27 11945713-0 1971 Preparation and isolation of the S-carboxymethyl derivative chains of human fibrinogen. carboxymethyl-coenzyme A 35-48 fibrinogen beta chain Homo sapiens 76-86 4931704-0 1971 [Rapid preparation of human fibrinogen labelled with iodine 125]. Iodine 53-59 fibrinogen beta chain Homo sapiens 28-38 4252126-0 1971 Difference in conformation of fibrinogen degradation products as revealed by hydrogen exchange and spectropolarimetry. Hydrogen 77-85 fibrinogen beta chain Homo sapiens 30-40 4257050-0 1971 [Use of a polyacrylamide gel gradient for the separation of fibrinogen degradation products. polyacrylamide 10-24 fibrinogen beta chain Homo sapiens 60-70 4258201-0 1971 The identification of fibrinogen derivatives in plasma and serum by agarose gel filtration. Sepharose 68-75 fibrinogen beta chain Homo sapiens 22-32 4258205-0 1971 A possible relation between the location of D and E fragments and of the N-terminal disulphide knots in fibrinogen molecule. disulphide 84-94 fibrinogen beta chain Homo sapiens 104-114 5503940-0 1970 Demonstration of a plasmatic cofactor different from fibrinogen necessary for platelet release by ADP and adrenaline. Adenosine Diphosphate 98-101 fibrinogen beta chain Homo sapiens 53-63 5503940-0 1970 Demonstration of a plasmatic cofactor different from fibrinogen necessary for platelet release by ADP and adrenaline. Epinephrine 106-116 fibrinogen beta chain Homo sapiens 53-63 4322244-0 1970 [Changes in the carbohydrate composition of fibrinogen in cases of acquired dysfibrinogenemia]. Carbohydrates 16-28 fibrinogen beta chain Homo sapiens 44-54 5456799-7 1970 This delayed regeneration time was not influenced by an excess of antivenene, but rapid regeneration to pretreatment values of plasma fibrinogen was immediately initiated by stimulating fibrinogen synthesis with subcutaneous turpentine. Turpentine 225-235 fibrinogen beta chain Homo sapiens 134-144 5456799-7 1970 This delayed regeneration time was not influenced by an excess of antivenene, but rapid regeneration to pretreatment values of plasma fibrinogen was immediately initiated by stimulating fibrinogen synthesis with subcutaneous turpentine. Turpentine 225-235 fibrinogen beta chain Homo sapiens 186-196 4248004-0 1970 Heterogeneity of human fibrinogen: possible relation to proteolysis by thrombin and plasmin as studies by SDS-polyacrylamide gel electrophoresis. Sodium Dodecyl Sulfate 106-109 fibrinogen beta chain Homo sapiens 23-33 4248004-0 1970 Heterogeneity of human fibrinogen: possible relation to proteolysis by thrombin and plasmin as studies by SDS-polyacrylamide gel electrophoresis. polyacrylamide 110-124 fibrinogen beta chain Homo sapiens 23-33 5534016-0 1970 [Studies on thromboplastin activity, fibrinolysis and uptake of radioactive iodine-labeled fibrinogen in various experimental tumors]. Iodine 76-82 fibrinogen beta chain Homo sapiens 91-101 5421053-0 1970 Adsorption of fibrinogen on modified polytetrafluoroethylene surfaces. Polytetrafluoroethylene 37-60 fibrinogen beta chain Homo sapiens 14-24 4246192-4 1970 Both the serum cholesterol and the plasma fibrinogen were related to the level of serum albumin, and those patients with high fibrinogen levels were also those with poor plasma fibrinolytic activator and those showing a steady deterioration. Cholesterol 15-26 fibrinogen beta chain Homo sapiens 126-136 11947453-1 1970 N-Terminal amino acid sequence analysis by Edman"s phenylisothiocyanate method on intact human fibrinogen revealed the first seven amino acids of the gamma-chain: H-Tyr-Val-Ala-Thr-Arg-Asp-Asn-. edman 43-48 fibrinogen beta chain Homo sapiens 95-105 11947453-1 1970 N-Terminal amino acid sequence analysis by Edman"s phenylisothiocyanate method on intact human fibrinogen revealed the first seven amino acids of the gamma-chain: H-Tyr-Val-Ala-Thr-Arg-Asp-Asn-. phenylisothiocyanate 51-71 fibrinogen beta chain Homo sapiens 95-105 4985342-0 1970 [Role of calcium in the structure of fibrinogen]. Calcium 9-16 fibrinogen beta chain Homo sapiens 37-47 5201592-0 1970 [Biological half-life of fibrinogen labelled with radioactive iodine I-131 in coronary disease]. Iodine-131 62-74 fibrinogen beta chain Homo sapiens 25-35 4189821-0 1970 Acrylamide gel electrophoresis of the S-sulfo derivatives of fibrinogen. Acrylamide 0-10 fibrinogen beta chain Homo sapiens 61-71 4189821-0 1970 Acrylamide gel electrophoresis of the S-sulfo derivatives of fibrinogen. Parathion 40-45 fibrinogen beta chain Homo sapiens 61-71 4244783-0 1970 The rotatory relaxation of fibrinogen in mucopolysaccharide solution detected by fluorescence-depolarization. Glycosaminoglycans 41-59 fibrinogen beta chain Homo sapiens 27-37 5412611-0 1970 Study of electrolytic labeling of fibrinogen with 131-iodine by Sephadex G-10 gel filtration. Iodine-131 50-60 fibrinogen beta chain Homo sapiens 34-44 5412611-0 1970 Study of electrolytic labeling of fibrinogen with 131-iodine by Sephadex G-10 gel filtration. sephadex 64-77 fibrinogen beta chain Homo sapiens 34-44 4243528-0 1969 Distribution of carbohydrate among the polypeptide chains and plasmin digest products of human fibrinogen. Carbohydrates 16-28 fibrinogen beta chain Homo sapiens 95-105 5358372-0 1969 [Fibrinolytic activity and fibrinogen level in children with rheumatic fever treated or not treated with prednisone]. Prednisone 105-115 fibrinogen beta chain Homo sapiens 27-37 5822576-1 1969 Chromatographic, ultracentrifugal, and related studies of the fibrinogen of a patient with a congenital disorder of fibrinogen (fibrinogen "Baltimore" have provided evidence of structural differences from normal.Diethylaminoethyl-cellulose (DEAE-cellulose) gradient elution chromatography demonstrated two major peaks in the elution pattern of fibrinogen Baltimore as was the case for normal fibrinogen. diethylaminoethyl-cellulose 212-239 fibrinogen beta chain Homo sapiens 62-72 5822576-1 1969 Chromatographic, ultracentrifugal, and related studies of the fibrinogen of a patient with a congenital disorder of fibrinogen (fibrinogen "Baltimore" have provided evidence of structural differences from normal.Diethylaminoethyl-cellulose (DEAE-cellulose) gradient elution chromatography demonstrated two major peaks in the elution pattern of fibrinogen Baltimore as was the case for normal fibrinogen. diethylaminoethyl-cellulose 212-239 fibrinogen beta chain Homo sapiens 116-126 5822576-1 1969 Chromatographic, ultracentrifugal, and related studies of the fibrinogen of a patient with a congenital disorder of fibrinogen (fibrinogen "Baltimore" have provided evidence of structural differences from normal.Diethylaminoethyl-cellulose (DEAE-cellulose) gradient elution chromatography demonstrated two major peaks in the elution pattern of fibrinogen Baltimore as was the case for normal fibrinogen. diethylaminoethyl-cellulose 212-239 fibrinogen beta chain Homo sapiens 116-126 5822576-1 1969 Chromatographic, ultracentrifugal, and related studies of the fibrinogen of a patient with a congenital disorder of fibrinogen (fibrinogen "Baltimore" have provided evidence of structural differences from normal.Diethylaminoethyl-cellulose (DEAE-cellulose) gradient elution chromatography demonstrated two major peaks in the elution pattern of fibrinogen Baltimore as was the case for normal fibrinogen. diethylaminoethyl-cellulose 212-239 fibrinogen beta chain Homo sapiens 116-126 5822576-1 1969 Chromatographic, ultracentrifugal, and related studies of the fibrinogen of a patient with a congenital disorder of fibrinogen (fibrinogen "Baltimore" have provided evidence of structural differences from normal.Diethylaminoethyl-cellulose (DEAE-cellulose) gradient elution chromatography demonstrated two major peaks in the elution pattern of fibrinogen Baltimore as was the case for normal fibrinogen. diethylaminoethyl-cellulose 212-239 fibrinogen beta chain Homo sapiens 116-126 5822576-1 1969 Chromatographic, ultracentrifugal, and related studies of the fibrinogen of a patient with a congenital disorder of fibrinogen (fibrinogen "Baltimore" have provided evidence of structural differences from normal.Diethylaminoethyl-cellulose (DEAE-cellulose) gradient elution chromatography demonstrated two major peaks in the elution pattern of fibrinogen Baltimore as was the case for normal fibrinogen. DEAE-Cellulose 241-255 fibrinogen beta chain Homo sapiens 116-126 4254313-0 1971 Acrylamide gel electrophoresis of fibrinogen and fibrin degradation products. Acrylamide 0-10 fibrinogen beta chain Homo sapiens 34-44 5772101-2 1969 Turnover rates of fibrinogen in burned patients labelled with [35S] methionine. Sulfur-35 63-66 fibrinogen beta chain Homo sapiens 18-28 5772101-2 1969 Turnover rates of fibrinogen in burned patients labelled with [35S] methionine. Methionine 68-78 fibrinogen beta chain Homo sapiens 18-28 5304832-0 1969 Effects of triiodothyronine-induced hypermetabolism on factor 8 and fibrinogen in man. Triiodothyronine 11-27 fibrinogen beta chain Homo sapiens 68-78 5304832-6 1969 Triiodothyronine-induced hypermetabolism increased the incorporation of selenomethionine-(75)Se into plasma fibrinogen. Triiodothyronine 0-16 fibrinogen beta chain Homo sapiens 108-118 5304832-6 1969 Triiodothyronine-induced hypermetabolism increased the incorporation of selenomethionine-(75)Se into plasma fibrinogen. Selenomethionine 72-88 fibrinogen beta chain Homo sapiens 108-118 5304832-6 1969 Triiodothyronine-induced hypermetabolism increased the incorporation of selenomethionine-(75)Se into plasma fibrinogen. Selenium 93-95 fibrinogen beta chain Homo sapiens 108-118 4974308-8 1969 The plasma fibrinogen migrated normally on paper and cellulose acetate electrophoresis, but on immunoelectrophoresis it displayed a faster mobility than normal fibrinogen. acetylcellulose 53-70 fibrinogen beta chain Homo sapiens 11-21 4974308-19 1969 Determination of the amino acid composition revealed a decreased content of lysine, glucosamine, and galactosamine in abnormal fibrinogen. Lysine 76-82 fibrinogen beta chain Homo sapiens 127-137 4974308-19 1969 Determination of the amino acid composition revealed a decreased content of lysine, glucosamine, and galactosamine in abnormal fibrinogen. Glucosamine 84-95 fibrinogen beta chain Homo sapiens 127-137 4974308-19 1969 Determination of the amino acid composition revealed a decreased content of lysine, glucosamine, and galactosamine in abnormal fibrinogen. Galactosamine 101-114 fibrinogen beta chain Homo sapiens 127-137 4974308-20 1969 Total carbohydrates, protein-bound hexoses, sialic acid, and hexosamine were decreased in the abnormal fibrinogen. Carbohydrates 6-19 fibrinogen beta chain Homo sapiens 103-113 4974308-20 1969 Total carbohydrates, protein-bound hexoses, sialic acid, and hexosamine were decreased in the abnormal fibrinogen. N-Acetylneuraminic Acid 44-55 fibrinogen beta chain Homo sapiens 103-113 4974308-20 1969 Total carbohydrates, protein-bound hexoses, sialic acid, and hexosamine were decreased in the abnormal fibrinogen. Hexosamines 61-71 fibrinogen beta chain Homo sapiens 103-113 4974308-22 1969 It is believed that the substitution of a strongly basic amino acid with a neutral hydroxy acid may result in considerable conformational changes in the N-terminal disulfide knot of fibrinogen which might affect the "active site" for polymerization. Amino Acids, Basic 51-67 fibrinogen beta chain Homo sapiens 182-192 4974308-22 1969 It is believed that the substitution of a strongly basic amino acid with a neutral hydroxy acid may result in considerable conformational changes in the N-terminal disulfide knot of fibrinogen which might affect the "active site" for polymerization. Hydroxy Acids 83-95 fibrinogen beta chain Homo sapiens 182-192 4974308-22 1969 It is believed that the substitution of a strongly basic amino acid with a neutral hydroxy acid may result in considerable conformational changes in the N-terminal disulfide knot of fibrinogen which might affect the "active site" for polymerization. Disulfides 164-173 fibrinogen beta chain Homo sapiens 182-192 4974308-23 1969 The lower carbohydrate content observed in "Fibrinogen Detroit" may have been the result of a change in primary and tertiary structure of the protein. Carbohydrates 10-22 fibrinogen beta chain Homo sapiens 44-54 5754842-4 1968 Another product prepared by digestion of fibrinogen with urokinase-activated plasminogen has been shown to possess the ability to enhance ADP-induced platelet aggregation. Adenosine Diphosphate 138-141 fibrinogen beta chain Homo sapiens 41-51 5665360-0 1968 [The use of fibrinogen labeled with I-131 in the diagnosis of thrombosis and atherosclerosis]. Iodine-131 36-41 fibrinogen beta chain Homo sapiens 12-22 5642099-0 1968 Control of fibrinogen biosynthesis: the role of free fatty acid. Fatty Acids, Nonesterified 48-63 fibrinogen beta chain Homo sapiens 11-21 5620201-0 1967 [Effect of cortisoe desoxycorticosterone and insulin on fibrinogen formation function of the liver in its toxic lesions]. cortisoe desoxycorticosterone 11-40 fibrinogen beta chain Homo sapiens 56-66 6021455-2 1967 Changes in fibrinogen concentration during and after cardiopulmonary bypass with particular reference to the effect of heparin neutralization on fibrinogen. Heparin 119-126 fibrinogen beta chain Homo sapiens 145-155 4231625-0 1967 [Study of the effect of ADP and thrombin on fibrinogen, the stabilising factor of fibrin and thrombosthenine in human blood platelets]. Adenosine Diphosphate 24-27 fibrinogen beta chain Homo sapiens 44-54 5996672-0 1966 Action of water-insoluble trypsin derivatives on fibrinogen clottability. Water 10-15 fibrinogen beta chain Homo sapiens 49-59 4162298-0 1966 125-I-labelled fibrinogen in cerebral malaria. Iodine-125 0-5 fibrinogen beta chain Homo sapiens 15-25 5977518-0 1966 [The diagnosis of thromboembolism processes using radioactive iodine-labeled fibrinogen and radioactive-labeled macroaggregates of albumin]. Iodine 62-68 fibrinogen beta chain Homo sapiens 77-87 5980541-0 1966 Influence of pH, pCO2 and pO2 on erythrocytic adsorption of fibrinogen. pco2 17-21 fibrinogen beta chain Homo sapiens 60-70 5980541-0 1966 Influence of pH, pCO2 and pO2 on erythrocytic adsorption of fibrinogen. PO-2 26-29 fibrinogen beta chain Homo sapiens 60-70 4181975-0 1966 [Change in the fibrinogen concentration in the blood following an intravenous injection of thrombin to dicoumarin-fed animals]. Dicumarol 103-113 fibrinogen beta chain Homo sapiens 15-25 14331671-0 1965 THE EFFECT OF ATROMID AND ATROMID-S ON PLASMA FIBRINOGEN AND PLASMINOGEN LEVELS. Clofibrate 14-21 fibrinogen beta chain Homo sapiens 46-56 14331671-0 1965 THE EFFECT OF ATROMID AND ATROMID-S ON PLASMA FIBRINOGEN AND PLASMINOGEN LEVELS. Clofibrate 26-35 fibrinogen beta chain Homo sapiens 46-56 5829184-0 1965 Effects of water-insoluble trypsin derivatives on fibrinogen. Water 11-16 fibrinogen beta chain Homo sapiens 50-60 5320281-0 1965 [Structure and role of the glucide fractions of fibrinogen]. glucide 27-34 fibrinogen beta chain Homo sapiens 48-58 5060578-1 1972 A ferritin-conjugated anti-fibrin/fibrinogen was localized by means of light and electron microscopy in artificial in vitro thrombi formed in the presence of the labeled antibody, and in preformed ADP-induced platelet aggregates. Adenosine Diphosphate 197-200 fibrinogen beta chain Homo sapiens 34-44 5775128-0 1969 In vivo transformation between fibrinogens of varying ethanol solubilities: a pathway of fibrinogen catabolism. Ethanol 54-61 fibrinogen beta chain Homo sapiens 31-41 5816627-2 1969 Plasma heparin resistance in relation to plasma fibrinogen and serum proteins]. Heparin 7-14 fibrinogen beta chain Homo sapiens 48-58 5810400-0 1969 [Variations in fibrinolytic activity and fibrinogen caused by xanthinol nicotinate in cases of diabetes mellitus with peripheral vascular lesions]. Xanthinol Niacinate 62-82 fibrinogen beta chain Homo sapiens 41-51 5788791-0 1969 The influence of beta-propiolactone on the coagulability of human fibrinogen. Propiolactone 17-35 fibrinogen beta chain Homo sapiens 66-76 5668263-0 1968 [Studies on the relationship between serum cholesterol and plasma fibrinogen]. Cholesterol 43-54 fibrinogen beta chain Homo sapiens 66-76 4296305-0 1968 N-terminal disulphide knot of human fibrinogen. disulphide 11-21 fibrinogen beta chain Homo sapiens 36-46 6059855-0 1967 The relationship between dextran precipitable fibrinogen and 170H corticosteroid levels in psychotic subjects. Dextrans 25-32 fibrinogen beta chain Homo sapiens 46-56 6024287-1 1967 Comparative study with 131-I-labeled antibody to human fibrinogen and neohydrin-203Hg. Iodine-131 23-28 fibrinogen beta chain Homo sapiens 55-65 6024295-0 1967 131-I-labeled antibodies to human fibrinogen. Iodine-131 0-5 fibrinogen beta chain Homo sapiens 34-44 6017979-0 1967 Fibrinogen from human plasma: preparation by precipitation with heavy-metal coordination complex. Metals 70-75 fibrinogen beta chain Homo sapiens 0-10 6017979-1 1967 Potassium tetrathiocyanato-(S)mercurate II [K(2)Hg(SCN)(4)] is used in a mild and rapid procedure for the isolation of human fibrinogen from fresh plasma. potassium tetrathiocyanato-(s)mercurate 0-39 fibrinogen beta chain Homo sapiens 125-135 6029930-1 1967 I. Helical content and the role of the tyrosine moiety in the fibrinogen molecule. Tyrosine 39-47 fibrinogen beta chain Homo sapiens 62-72 5955363-0 1966 Studies with iodine-131-labeled antibody to human fibrinogen for diagnosis and therapy of tumors. Iodine 13-19 fibrinogen beta chain Homo sapiens 50-60 5923078-0 1966 Effect of hematoporphyrin and light on human fibrinogen. Hematoporphyrins 10-25 fibrinogen beta chain Homo sapiens 45-55 5936177-0 1966 Turnover of 131-I-labelled fibrinogen in man. Iodine-131 12-17 fibrinogen beta chain Homo sapiens 27-37 5941205-0 1966 Study of carbohydrate release during the clotting of fibrinogen. Carbohydrates 9-21 fibrinogen beta chain Homo sapiens 53-63 4168947-0 1966 [Quantitative determination of fibrinogen in blood plasma by agar gel electrophoresis]. Agar 61-65 fibrinogen beta chain Homo sapiens 31-41 5862426-0 1965 Molecular weight of human fibrinogen derived from phosphorus determinations. Phosphorus 50-60 fibrinogen beta chain Homo sapiens 26-36 5862426-4 1965 The ;cold insoluble residue" obtained during fibrinogen preparation has a higher phosphorus content than the purified fibrinogen. Phosphorus 81-91 fibrinogen beta chain Homo sapiens 45-55 5862426-6 1965 Evidence showed that adsorption of phospholipids or phosphorus-containing fibrinopeptides on purified fibrinogen or fibrin was unlikely. Phosphorus 52-62 fibrinogen beta chain Homo sapiens 102-112 5862426-10 1965 On the basis of phosphorus determinations the average molecular weight of human fibrinogen cannot be less than 342000 (304000-383000) for a group of ten donors, and 265000 for two other persons, assuming 1 phosphorus atom/molecule and incomplete splitting of the phosphorus-containing fibrinopeptide. Phosphorus 16-26 fibrinogen beta chain Homo sapiens 80-90 5862426-10 1965 On the basis of phosphorus determinations the average molecular weight of human fibrinogen cannot be less than 342000 (304000-383000) for a group of ten donors, and 265000 for two other persons, assuming 1 phosphorus atom/molecule and incomplete splitting of the phosphorus-containing fibrinopeptide. Phosphorus 206-216 fibrinogen beta chain Homo sapiens 80-90 5862426-10 1965 On the basis of phosphorus determinations the average molecular weight of human fibrinogen cannot be less than 342000 (304000-383000) for a group of ten donors, and 265000 for two other persons, assuming 1 phosphorus atom/molecule and incomplete splitting of the phosphorus-containing fibrinopeptide. Phosphorus 206-216 fibrinogen beta chain Homo sapiens 80-90 5862426-13 1965 Fibrinolysis was a possible cause of lower phosphorus contents found in isolated fibrinogen and fibrin from a donor who showed apprehension during blood collection and in a fibrinogen preparation that had been submitted to prolonged dialysis. Phosphorus 43-53 fibrinogen beta chain Homo sapiens 81-91 5862426-13 1965 Fibrinolysis was a possible cause of lower phosphorus contents found in isolated fibrinogen and fibrin from a donor who showed apprehension during blood collection and in a fibrinogen preparation that had been submitted to prolonged dialysis. Phosphorus 43-53 fibrinogen beta chain Homo sapiens 173-183 14325871-0 1965 LIMITATIONS OF FIBRINOGEN-POLYMYXIN MEDIUM IN DETECTING COAGULASE-POSITIVE STAPHYLOCOCCI IN RAW MILK. polymyxin medium 26-42 fibrinogen beta chain Homo sapiens 15-25 14325871-1 1965 A fibrinogen-polymyxin medium and Staphylococcus Medium 110 were used in the isolation of coagulase-positive staphylococci in raw milk. polymyxin medium 13-29 fibrinogen beta chain Homo sapiens 2-12 14325871-3 1965 A significantly greater number of coagulase-positive staphylococci were identified by the tube test than were revealed by halo formation on fibrinogen-polymyxin medium. polymyxin medium 151-167 fibrinogen beta chain Homo sapiens 140-150 14312437-0 1965 [LOCALIZATION OF THE GLUCIDE CHAINS IN THE FIBRINOGEN MOLECULE]. glucide 21-28 fibrinogen beta chain Homo sapiens 43-53 14275603-0 1965 RUPTURE OF FIBRINOGEN DISULFIDE BONDS BY CYSTEINE. Disulfides 22-31 fibrinogen beta chain Homo sapiens 11-21 5822576-1 1969 Chromatographic, ultracentrifugal, and related studies of the fibrinogen of a patient with a congenital disorder of fibrinogen (fibrinogen "Baltimore" have provided evidence of structural differences from normal.Diethylaminoethyl-cellulose (DEAE-cellulose) gradient elution chromatography demonstrated two major peaks in the elution pattern of fibrinogen Baltimore as was the case for normal fibrinogen. DEAE-Cellulose 241-255 fibrinogen beta chain Homo sapiens 116-126 14275603-0 1965 RUPTURE OF FIBRINOGEN DISULFIDE BONDS BY CYSTEINE. Cysteine 41-49 fibrinogen beta chain Homo sapiens 11-21 5822576-1 1969 Chromatographic, ultracentrifugal, and related studies of the fibrinogen of a patient with a congenital disorder of fibrinogen (fibrinogen "Baltimore" have provided evidence of structural differences from normal.Diethylaminoethyl-cellulose (DEAE-cellulose) gradient elution chromatography demonstrated two major peaks in the elution pattern of fibrinogen Baltimore as was the case for normal fibrinogen. DEAE-Cellulose 241-255 fibrinogen beta chain Homo sapiens 116-126 5822576-1 1969 Chromatographic, ultracentrifugal, and related studies of the fibrinogen of a patient with a congenital disorder of fibrinogen (fibrinogen "Baltimore" have provided evidence of structural differences from normal.Diethylaminoethyl-cellulose (DEAE-cellulose) gradient elution chromatography demonstrated two major peaks in the elution pattern of fibrinogen Baltimore as was the case for normal fibrinogen. DEAE-Cellulose 241-255 fibrinogen beta chain Homo sapiens 116-126 5862557-0 1965 Influence of fibrinogen on the aggregation of washed human blood platelets induced by adenosine diphosphate, thrombin, collagen, and adrenaline. Adenosine Diphosphate 86-107 fibrinogen beta chain Homo sapiens 13-23 14249121-0 1964 INHIBITION OF THE FIBRINOGEN-PLASMIN REACTION BY OMEGA-AMINOCARBOXYLIC ACIDS AND ALKYLAMINES. omega-aminocarboxylic acids 49-76 fibrinogen beta chain Homo sapiens 18-28 14294199-0 1965 [LABELLING OF FIBRINOGEN BY A METHOD USING CHLORAMINE T]. chloramine-T 43-55 fibrinogen beta chain Homo sapiens 14-24 14254709-0 1964 EFFECT OF FIBRINOGEN ON THE AGGREGATION OF PLATELETS BY ADENOSINE DIPHOSPHATE. Adenosine Diphosphate 56-77 fibrinogen beta chain Homo sapiens 10-20 14249121-0 1964 INHIBITION OF THE FIBRINOGEN-PLASMIN REACTION BY OMEGA-AMINOCARBOXYLIC ACIDS AND ALKYLAMINES. alkylamines 81-92 fibrinogen beta chain Homo sapiens 18-28 14191721-0 1964 TURNOVER AND DISTRIBUTION OF 131-IODINE-LABELLED HUMAN FIBRINOGEN. Iodine 33-39 fibrinogen beta chain Homo sapiens 55-65 14283831-0 1964 [METHODOLOGY FOR THE DEMONSTRATION OF MEDIAN SUPRA-UMBILICAL NEOPLASMS WITH I-131-LABELLED FIBRINOGEN]. Iodine-131 76-81 fibrinogen beta chain Homo sapiens 91-101 14187489-0 1964 PLASMA-FIBRINOGEN LEVELS AFTER LONG-TERM WARFARIN THERAPY. Warfarin 41-49 fibrinogen beta chain Homo sapiens 7-17 14224636-0 1964 TOXICITY OF HEPARINOIDS, WITH SPECIAL REFERENCE TO THE PRECIPITATION OF FIBRINOGEN. Heparinoids 12-23 fibrinogen beta chain Homo sapiens 72-82 14298739-0 1964 [EFFECT OF CALCIUM, IONIC STRENGTH AND TEMPERATURE ON THE ENZYMATIC PHASE OF FIBRINOGEN CONVERSION TO FIBRIN]. Calcium 11-18 fibrinogen beta chain Homo sapiens 77-87 14073163-0 1963 THE PREPARATION AND SOME PROPERTIES OF FIBRINOGEN PRECIPITATED FROM HUMAN PLASMA BY GLYCINE. Glycine 84-91 fibrinogen beta chain Homo sapiens 39-49 14154008-0 1964 [PERMEABILITY OF ISCHEMIC HEPATIC TISSUE TO I-131 LABELED FIBRINOGEN]. Iodine-131 44-49 fibrinogen beta chain Homo sapiens 58-68 14173732-0 1964 [SPLITTING DISULFIDE FIBRINOGEN BONDS WITH CYSTEINE]. Disulfides 11-20 fibrinogen beta chain Homo sapiens 21-31 14173732-0 1964 [SPLITTING DISULFIDE FIBRINOGEN BONDS WITH CYSTEINE]. Cysteine 43-51 fibrinogen beta chain Homo sapiens 21-31 14119619-0 1963 [LABELING OF FIBRINOGEN WITH IODINE-131 BY AN ELECTROLYTIC METHOD. Iodine-131 30-40 fibrinogen beta chain Homo sapiens 14-24 14080969-0 1963 [DETERMINATION OF BLOOD PLASMA FIBRINOGEN BY THE AGAR ELECTROPHORESIS METHOD]. Agar 49-53 fibrinogen beta chain Homo sapiens 31-41 14131109-0 1963 PARTICIPATION OF THE COAGULATION MECHANISM IN TUMOR LOCALIZATION OF I-131-LABELLED FIBRINOGEN. Iodine-131 68-73 fibrinogen beta chain Homo sapiens 83-93 13980541-0 1963 The precipitation of fibrinogen by heparin at pH 4.8. Heparin 35-42 fibrinogen beta chain Homo sapiens 21-31 13971745-0 1963 On the occurrence of phosphorus in fibrinogen. Phosphorus 21-31 fibrinogen beta chain Homo sapiens 35-45 13928162-0 1963 Sialic acid in fibrinogen and "vulcanization" of the fibrin clot. N-Acetylneuraminic Acid 0-11 fibrinogen beta chain Homo sapiens 15-25 13935150-0 1963 [The structure and role of the sugar moiety of fibrinogen and fibrin: On the bonding of sugar compounds]. Sugars 31-36 fibrinogen beta chain Homo sapiens 47-57 14011475-2 1963 Fibrinogen content of the blood plasma in several childhood diseases and during administration of adrenal cortex steroids]. Steroids 113-121 fibrinogen beta chain Homo sapiens 0-10 13935150-0 1963 [The structure and role of the sugar moiety of fibrinogen and fibrin: On the bonding of sugar compounds]. Sugars 88-93 fibrinogen beta chain Homo sapiens 47-57 13978519-0 1963 Preparation of purified I-131 labeled antisera to human fibrinogen. Iodine-131 24-29 fibrinogen beta chain Homo sapiens 56-66 14104118-0 1963 [POLAROGRAPHIC CONTROL OF SELECTIVE OXIDATION OF FIBRINOGEN BY PERIODIC ACID]. Periodic Acid 63-76 fibrinogen beta chain Homo sapiens 49-59 14065618-0 1963 EARLY DETECTION OF DEEP VENOUS THROMBOSIS URING IODINE-131 TAGGED FIBRINOGEN. Iodine 48-54 fibrinogen beta chain Homo sapiens 66-76 14045801-0 1963 [THE TURNOVER OF PLASMA FIBRINOGEN STUDIED BY I-131-LABELED FIBRINOGEN]. Iodine-131 46-51 fibrinogen beta chain Homo sapiens 24-34 14045801-0 1963 [THE TURNOVER OF PLASMA FIBRINOGEN STUDIED BY I-131-LABELED FIBRINOGEN]. Iodine-131 46-51 fibrinogen beta chain Homo sapiens 60-70 13887961-0 1962 Enzymatic activities associated with clotting of fibrinogen by staphylocoagulase and coagulase-reacting factor and their inhibition by disopropylfluophosphate. disopropylfluophosphate 135-158 fibrinogen beta chain Homo sapiens 49-59 13887961-2 1962 Enzymatic activities associated with clotting of fibrinogen by staphylocoagulase and coagulase-reacting factor and their inhibition by diisopropylfluorophosphate. Isoflurophate 135-161 fibrinogen beta chain Homo sapiens 49-59 13919689-0 1961 [Effect of heparin and protamine on fibrinogen precipitation]. Heparin 11-18 fibrinogen beta chain Homo sapiens 36-46 13707068-0 1961 Estimation of plasma fibrinogen, using sodium sulfite fractionation. sodium sulfite 39-53 fibrinogen beta chain Homo sapiens 21-31 13706166-0 1960 The effect of EDTA on human fibrinogen and its significance for the coagulation of fibrinogen with thrombin. Edetic Acid 14-18 fibrinogen beta chain Homo sapiens 28-38 13706166-0 1960 The effect of EDTA on human fibrinogen and its significance for the coagulation of fibrinogen with thrombin. Edetic Acid 14-18 fibrinogen beta chain Homo sapiens 83-93 13850331-0 1960 Precipitation of human fibrinogen with heparin. Heparin 39-46 fibrinogen beta chain Homo sapiens 23-33 14441863-0 1959 Interaction of fibrinogen with dextran sulfate. Dextran Sulfate 31-46 fibrinogen beta chain Homo sapiens 15-25 14441863-1 1959 Interactions of fibrinogen with dextran sulfate, dextran, and carboxymethyl cellulose were investigated by turbidity measurement, chemical analysis, and electrophoresis. Dextran Sulfate 32-47 fibrinogen beta chain Homo sapiens 16-26 14441863-1 1959 Interactions of fibrinogen with dextran sulfate, dextran, and carboxymethyl cellulose were investigated by turbidity measurement, chemical analysis, and electrophoresis. Dextrans 32-39 fibrinogen beta chain Homo sapiens 16-26 14441863-1 1959 Interactions of fibrinogen with dextran sulfate, dextran, and carboxymethyl cellulose were investigated by turbidity measurement, chemical analysis, and electrophoresis. Carboxymethylcellulose Sodium 62-85 fibrinogen beta chain Homo sapiens 16-26 13634659-0 1959 [Immunochemical study of human fibrinogen & its derivatives]. Adenosine Monophosphate 43-46 fibrinogen beta chain Homo sapiens 31-41 14294804-4 1965 Fibrinogen-tellurite-glycine plates were very useful for the isolation of staphylococci from milk in the presence of other microorganisms and for the simultaneous identification of coagulase positive strains. Glycine 21-28 fibrinogen beta chain Homo sapiens 0-10 24546816-0 1962 Research directed toward the use of I-131 labeled fibrinogen and antibody to fibrin in the localization and treatment of tumors. Iodine-131 36-41 fibrinogen beta chain Homo sapiens 50-60 13895378-0 1962 [Differences in the effect of Thrombocid on the serum and fibrinogen, determined with differential blood sedimentation]. Pentosan Sulfuric Polyester 30-40 fibrinogen beta chain Homo sapiens 58-68 13984284-2 1962 Contribution to the study of the influence of dextran on fibrinogen]. Dextrans 46-53 fibrinogen beta chain Homo sapiens 57-67 13707067-0 1961 Estimation of plasma fibrinogen using sodium sulfite fractionation. sodium sulfite 38-52 fibrinogen beta chain Homo sapiens 21-31 14433991-0 1960 The interaction of dextran with serum albumin, gamma globulin, and fibrinogen. Dextrans 19-26 fibrinogen beta chain Homo sapiens 47-77 14433991-1 1960 The interaction between dextran and serum albumin, gamma globulin, and fibrinogen can be studied by an electrophoretic method, which depends on obtaining electrophoretic patterns, first of each protein, then of dextran, and finally of mixtures of each protein with dextran. Dextrans 24-31 fibrinogen beta chain Homo sapiens 51-81 14433991-1 1960 The interaction between dextran and serum albumin, gamma globulin, and fibrinogen can be studied by an electrophoretic method, which depends on obtaining electrophoretic patterns, first of each protein, then of dextran, and finally of mixtures of each protein with dextran. Dextrans 211-218 fibrinogen beta chain Homo sapiens 51-81 14433991-1 1960 The interaction between dextran and serum albumin, gamma globulin, and fibrinogen can be studied by an electrophoretic method, which depends on obtaining electrophoretic patterns, first of each protein, then of dextran, and finally of mixtures of each protein with dextran. Dextrans 211-218 fibrinogen beta chain Homo sapiens 51-81 14433991-6 1960 The method shows that a mixture of dextran and fibrinogen gives only one slowly moving spike (pH 6.6 to 8.6), the area under which is the sum of the areas under the dextran and the fibrinogen spikes taken separately. Dextrans 35-42 fibrinogen beta chain Homo sapiens 181-191 14433991-6 1960 The method shows that a mixture of dextran and fibrinogen gives only one slowly moving spike (pH 6.6 to 8.6), the area under which is the sum of the areas under the dextran and the fibrinogen spikes taken separately. Dextrans 165-172 fibrinogen beta chain Homo sapiens 47-57 14065809-0 1963 EARLY DETECTION OF DEEP VENOUS THROMBOSIS DURING IODINE-131 TAGGED FIBRINOGEN. Iodine 50-56 fibrinogen beta chain Homo sapiens 68-78 13607764-0 1958 [Qualitative changes in fibrinogen in pathological conditions; the carbohydrate content of fibrinogen; preliminary note]. Carbohydrates 67-79 fibrinogen beta chain Homo sapiens 91-101 13541068-0 1958 [Synthesis of fibrinogen in a case of congenital afibrogenemia studied by means of S35 labeled thio-amino acids]. thio-amino acids 95-111 fibrinogen beta chain Homo sapiens 14-24 13616521-0 1958 [The fibrinogen molecule & its contents. Adenosine Monophosphate 26-29 fibrinogen beta chain Homo sapiens 5-15 13583123-0 1958 Action of serotonin on conversion of fibrinogen to fibrin. Serotonin 10-19 fibrinogen beta chain Homo sapiens 37-47 13554687-2 1958 Relation between the blood concentration of a labile component of fibrinogen & the velocity of erythrocyte sedimentation]. Adenosine Monophosphate 78-81 fibrinogen beta chain Homo sapiens 66-76 13488575-0 1957 [Study of fibrinogen precipitation by heparin at low temperatures]. Heparin 38-45 fibrinogen beta chain Homo sapiens 10-20 13527544-2 1958 The reactions of total plasma fibrinogen & its labile fractions to low temperatures & salt effects in various pathological conditions]. Adenosine Monophosphate 42-45 fibrinogen beta chain Homo sapiens 30-40 13527544-2 1958 The reactions of total plasma fibrinogen & its labile fractions to low temperatures & salt effects in various pathological conditions]. Adenosine Monophosphate 89-92 fibrinogen beta chain Homo sapiens 30-40 13527544-2 1958 The reactions of total plasma fibrinogen & its labile fractions to low temperatures & salt effects in various pathological conditions]. Salts 94-98 fibrinogen beta chain Homo sapiens 30-40 13595293-0 1958 [Variations of fibrinogen content around birth in healthy & toxemic women]. Adenosine Monophosphate 59-62 fibrinogen beta chain Homo sapiens 15-25 13466665-0 1957 [Immunochemical studies on the presence of fibrinogen in washed human platelet extracts & in various leukocyte extracts]. Adenosine Monophosphate 89-92 fibrinogen beta chain Homo sapiens 43-53 13418505-0 1957 [Determination of prothrombin time (Quick test) and plasma fibrinogen in pulmonary tuberculosis treated with pyrazinamide]. Pyrazinamide 109-121 fibrinogen beta chain Homo sapiens 59-69 13259907-0 1955 [Behavior of hematic fibrinogen during treatment with marcoumar and with marcoumar and vitamin K; clinical and experimental aspects]. Phenprocoumon 54-63 fibrinogen beta chain Homo sapiens 21-31 14385379-0 1955 Effect of synthetic basic polyamino acids on the clotting of fibrinogen and on fibrinolysis. Tolonium Chloride 20-25 fibrinogen beta chain Homo sapiens 61-71 13259907-0 1955 [Behavior of hematic fibrinogen during treatment with marcoumar and with marcoumar and vitamin K; clinical and experimental aspects]. Vitamin K 87-96 fibrinogen beta chain Homo sapiens 21-31 14385379-0 1955 Effect of synthetic basic polyamino acids on the clotting of fibrinogen and on fibrinolysis. polyamino acids 26-41 fibrinogen beta chain Homo sapiens 61-71 14351141-0 1955 The action of poly-lysine on the conversion of fibrinogen into fibrin by coagulase thrombin. Polylysine 14-25 fibrinogen beta chain Homo sapiens 47-57 14353885-0 1955 The effect of phosphorylated hesperidin on the polymerization of fibrinogen as studied by light scattering. Hesperidin 29-39 fibrinogen beta chain Homo sapiens 65-75 14387730-0 1955 The effect of thrombin on the polysaccharide of fibrinogen; a preliminary note. Polysaccharides 30-44 fibrinogen beta chain Homo sapiens 48-58 13237261-0 1954 Fibrinogen preservation in serum after heparin. Heparin 39-46 fibrinogen beta chain Homo sapiens 0-10 14364996-0 1954 [Effect of actinomycetin on fibrinogen and fibrin]. actinomycetin 11-24 fibrinogen beta chain Homo sapiens 28-38 13174525-0 1954 Photometric microdetermination of plasma fibrinogen with a thrombin-ninhydrin procedure. thrombin-ninhydrin 59-77 fibrinogen beta chain Homo sapiens 41-51 13092990-0 1953 The determination of plasma fibrinogen by turbidity with ammonium sulfate. Ammonium Sulfate 57-73 fibrinogen beta chain Homo sapiens 28-38 13130687-0 1954 The accelerating effect of calcium and other cations on the conversion of fibrinogen to fibrin. Calcium 27-34 fibrinogen beta chain Homo sapiens 74-84 13031627-2 1953 Influence of pH, ionic strength and hexamethylene glycol concentration on the polymerization of fibrinogen. hexamethylene glycol 36-56 fibrinogen beta chain Homo sapiens 96-106 13081612-0 1953 On the polysaccharide of fibrinogen and fibrin. Polysaccharides 7-21 fibrinogen beta chain Homo sapiens 25-35 13091884-0 1953 [Polysaccharide of fibrinogen and fibrin]. Polysaccharides 1-15 fibrinogen beta chain Homo sapiens 19-29 13128694-0 1953 [The carbohydrate group in fibrinogen]. Carbohydrates 5-17 fibrinogen beta chain Homo sapiens 27-37 12984520-0 1952 Plasma fibrinogen and the sedimentation rate in rheumatoid arthritis, and their response to the administration of cortisone and adrenocorticotropic hormone (ACTH); interim report. Cortisone 114-123 fibrinogen beta chain Homo sapiens 7-17 14846749-2 1951 The relation of fibrinogen concentration to the beta naphthol reaction of plasma. 2-naphthol 48-61 fibrinogen beta chain Homo sapiens 16-26 14947852-0 1952 Interaction of dextran and fibrinogen. Dextrans 15-22 fibrinogen beta chain Homo sapiens 27-37 14938434-0 1952 Plasma fibrinogen and the sedimentation rate in rheumatoid arthritis, and their response to the administration of cortisone and adrenocorticotropic hormone (ACTH). Cortisone 114-123 fibrinogen beta chain Homo sapiens 7-17 14911983-0 1951 Solubility of bovin fibrinogen in ethanol-water mixtures. Ethanol 34-41 fibrinogen beta chain Homo sapiens 20-30 14911983-0 1951 Solubility of bovin fibrinogen in ethanol-water mixtures. Water 42-47 fibrinogen beta chain Homo sapiens 20-30 14834645-0 1951 [The effect of certain antagonists of fibrinogen insolubilization by thrombine, before and after heating of the plasma]. thrombine 69-78 fibrinogen beta chain Homo sapiens 38-48 14830360-0 1951 [The effect, in the presence and absence of ionized calcium, of certain antagonists of the thrombin conversion of fibrinogen]. Calcium 52-59 fibrinogen beta chain Homo sapiens 114-124 14900980-0 1951 Influence of dextran on the conversion of fibrinogen to fibrin. Dextrans 13-20 fibrinogen beta chain Homo sapiens 42-52 18129500-0 1949 Influence of serum proteins and calcium ions upon the velocity of the reaction thrombin fibrinogen; second phase of blood coagulation. Calcium 32-39 fibrinogen beta chain Homo sapiens 88-98 15442967-0 1950 [Determination of proteins, albumin, globulin and diagnostic determination of fibrinogen in the blood based upon the ring formation in overlaying of serum on nitric acid]. Nitric Acid 158-169 fibrinogen beta chain Homo sapiens 78-88 18894930-0 1948 The mechanism of the clotting of fibrinogen with formaldehyde and quinone; interactions between formaldehyde and thrombin. quinone 66-73 fibrinogen beta chain Homo sapiens 33-43 18856441-0 1948 Influence of polyhydric alcohols on the clotting of fibrinogen. Glycerol 13-32 fibrinogen beta chain Homo sapiens 52-62 18894930-0 1948 The mechanism of the clotting of fibrinogen with formaldehyde and quinone; interactions between formaldehyde and thrombin. Formaldehyde 96-108 fibrinogen beta chain Homo sapiens 33-43 20265832-0 1947 The plasmatic cofactor of thromboplastin; its adsorption, with prothrombin and fibrinogen, by alumina and tricalcium phosphate gels. Aluminum Oxide 94-101 fibrinogen beta chain Homo sapiens 79-89 18894925-0 1948 The effect of bile salts on fibrinogen and its clotting. Bile Acids and Salts 14-24 fibrinogen beta chain Homo sapiens 28-38 18894930-0 1948 The mechanism of the clotting of fibrinogen with formaldehyde and quinone; interactions between formaldehyde and thrombin. Formaldehyde 49-61 fibrinogen beta chain Homo sapiens 33-43 20265832-0 1947 The plasmatic cofactor of thromboplastin; its adsorption, with prothrombin and fibrinogen, by alumina and tricalcium phosphate gels. tricalcium phosphate 106-126 fibrinogen beta chain Homo sapiens 79-89 21013792-0 1946 Effect of salicylate on plasma fibrinogen and sedimentation rate in rheumatic and non-rheumatic patients. Salicylates 10-20 fibrinogen beta chain Homo sapiens 31-41 19873444-6 1945 The combination of thrombin with fibrinogen most probably takes place by hydrogen bonds. Hydrogen 73-81 fibrinogen beta chain Homo sapiens 33-43 19873443-2 1945 THE RESULTS OF THE STUDY OF THE INHIBITING EFFECT OF NEUTRAL SALTS UPON THE CLOTTING TENDENCY OF FIBRINOGEN BY THROMBIN MAY BE SUMMARISED AS FOLLOWS: Salts like NaCl and KCl inhibit only weakly. Sodium Chloride 161-165 fibrinogen beta chain Homo sapiens 97-107 19873443-2 1945 THE RESULTS OF THE STUDY OF THE INHIBITING EFFECT OF NEUTRAL SALTS UPON THE CLOTTING TENDENCY OF FIBRINOGEN BY THROMBIN MAY BE SUMMARISED AS FOLLOWS: Salts like NaCl and KCl inhibit only weakly. Potassium Chloride 170-173 fibrinogen beta chain Homo sapiens 97-107 19873444-5 1945 The primary reaction, the formation of profibrin by combination of thrombin and fibrinogen, is inhibited by urea but not by neutral salts. Urea 108-112 fibrinogen beta chain Homo sapiens 80-90 16560501-0 1942 Lysis of Precipitated Fibrinogen in Agar Medium by Staphylococci. Agar 36-40 fibrinogen beta chain Homo sapiens 22-32 19870699-1 1937 The bleeding tendency in acute chloroform intoxication is due to deficiency in both plasma fibrinogen and plasma prothrombin. Chloroform 31-41 fibrinogen beta chain Homo sapiens 91-101 19872889-1 1935 ON THE CONSTANCY OF THE HYDROGEN ION CONCENTRATION DURING THE COAGULATION OF FIBRINOGEN BY THROMBIN. Hydrogen 24-32 fibrinogen beta chain Homo sapiens 77-87 19872865-6 1935 Calcium, a platelet factor, and a plasma factor (prothrombin) interact to form thrombin, and this then acts upon fibrinogen to form fibrin. Calcium 0-7 fibrinogen beta chain Homo sapiens 113-123 16742973-0 1921 The Action of Sodium Hydroxide upon Coagulation of Fibrinogen. Sodium Hydroxide 14-30 fibrinogen beta chain Homo sapiens 51-61 33714824-9 2021 The concentration of fibrinogen increased after exposure to quartz diorite, while it decreased after exposures to rhomb porphyry and lactose. quartz diorite 60-74 fibrinogen beta chain Homo sapiens 21-31 33714824-9 2021 The concentration of fibrinogen increased after exposure to quartz diorite, while it decreased after exposures to rhomb porphyry and lactose. Lactose 133-140 fibrinogen beta chain Homo sapiens 21-31 33714824-10 2021 Type of material was a statistically significant explanatory variable for the concentration of fibrinogen, with the most significant increase occurring 24 h post-exposure to quartz diorite. quartz diorite 174-188 fibrinogen beta chain Homo sapiens 95-105 13612170-0 1958 A method of preparing fibrinogen tagged with radioactive iodine. Iodine 57-63 fibrinogen beta chain Homo sapiens 22-32 16742020-0 1906 On the Influence of Calcium Salts upon the Heat-Coagulation of Fibrinogen and other Proteids. calcium salts 20-33 fibrinogen beta chain Homo sapiens 63-73 33422688-7 2021 RESULTS: Under bortezomib, VASP phosphorylation was less inducible and nitric oxide-induced inhibition of fibrinogen binding was slightly reduced. Bortezomib 15-25 fibrinogen beta chain Homo sapiens 106-116 33422688-7 2021 RESULTS: Under bortezomib, VASP phosphorylation was less inducible and nitric oxide-induced inhibition of fibrinogen binding was slightly reduced. Nitric Oxide 71-83 fibrinogen beta chain Homo sapiens 106-116 33422688-9 2021 Induced expression of activated fibrinogen receptors and fibrinogen binding were not significantly influenced by incubation with bortezomib for 24 h. Aggregation values with threshold agonist concentrations were increased under bortezomib. Bortezomib 228-238 fibrinogen beta chain Homo sapiens 32-42 34059762-13 2021 NLR and FIB showed high specificity, which may be a valuable tool for the diagnosis of TBAD. tbad 87-91 fibrinogen beta chain Homo sapiens 8-11 33755208-6 2021 STUDY DESIGN AND METHODS: Hemostatic adjunct study products were psoralen-treated PR-cryoprecipitated fibrinogen complex (PR-Cryo FC), cryoprecipitate (Cryo), and fibrinogen concentrates (FibCon). Ficusin 65-73 fibrinogen beta chain Homo sapiens 102-112 33831568-13 2021 Here, using proteomic analyses we showed that the osteogenic properties of 80-200 microm BCP particles embedded in a blood clot is associated with a higher expression of fibrinogen. hydroxyapatite-beta tricalcium phosphate 89-92 fibrinogen beta chain Homo sapiens 170-180 33831568-14 2021 Fibrinogen upregulates the Myd88- and NF-kappaB-dependent TLR4 pathway in blood cells and, BCP-induced TLR4 activation is mediated by the LBP and CD14 proteins. hydroxyapatite-beta tricalcium phosphate 91-94 fibrinogen beta chain Homo sapiens 0-10 33998409-10 2021 Results Patients after CHVD treated with warfarin had higher values of international normalized ratio (INR) and activated partial thromboplastin time (aPPT) and lower values of prothrombin index (PTI), fibrinogen (p<0.001 for all), hemoglobin (p=0.0016), and hematocrit (p=0,0032) than patients after CB treated with antiplatelet drugs. Warfarin 44-52 fibrinogen beta chain Homo sapiens 205-215 33752184-4 2021 Both pSBMA and pCBMA brushes coatings were found to greatly reduce adsorption of bovine serum albumin (BSA) and fibrinogen (Fib) onto the TNTs, showing excellent protein resistance. sulfobetaine methacrylate polymer 5-10 fibrinogen beta chain Homo sapiens 112-122 33752184-4 2021 Both pSBMA and pCBMA brushes coatings were found to greatly reduce adsorption of bovine serum albumin (BSA) and fibrinogen (Fib) onto the TNTs, showing excellent protein resistance. sulfobetaine methacrylate polymer 5-10 fibrinogen beta chain Homo sapiens 124-127 33752184-4 2021 Both pSBMA and pCBMA brushes coatings were found to greatly reduce adsorption of bovine serum albumin (BSA) and fibrinogen (Fib) onto the TNTs, showing excellent protein resistance. polycarboxybetaine methacrylate 15-20 fibrinogen beta chain Homo sapiens 112-122 33752184-4 2021 Both pSBMA and pCBMA brushes coatings were found to greatly reduce adsorption of bovine serum albumin (BSA) and fibrinogen (Fib) onto the TNTs, showing excellent protein resistance. polycarboxybetaine methacrylate 15-20 fibrinogen beta chain Homo sapiens 124-127 33752184-6 2021 The conformation of the protein adsorbed to the substrates was analyzed at the molecular level by Fourier-transform infrared reflection absorption spectroscopy, which revealed that the BSA adsorbed on the polyzwitterion-modified TNTs adopted significantly different secondary structures from that on the virgin TNTs, whereas the conformation of the adsorbed Fib remained basically the same. tnts 229-233 fibrinogen beta chain Homo sapiens 358-361 33582167-9 2021 In preeclampsia patients, serum 4-Hydroxyglutamate was negatively correlated with PT and APTT, positively correlated with Fib content (p < 0.001); serum miR-149-5p was dramatically positively correlated with PT and APTT, negatively correlated with Fib content (p < 0.001). 4-hydroxyglutamate 32-50 fibrinogen beta chain Homo sapiens 122-125 33582167-9 2021 In preeclampsia patients, serum 4-Hydroxyglutamate was negatively correlated with PT and APTT, positively correlated with Fib content (p < 0.001); serum miR-149-5p was dramatically positively correlated with PT and APTT, negatively correlated with Fib content (p < 0.001). -149-5p 156-163 fibrinogen beta chain Homo sapiens 248-251 32920751-0 2021 Dynamic changes in fibrinogen and D-dimer levels in COVID-19 patients on nafamostat mesylate. nafamostat 73-92 fibrinogen beta chain Homo sapiens 19-29 33440293-0 2021 Hypochlorite-induced aggregation of fibrinogen underlies a novel antioxidant role in blood plasma. Hypochlorous Acid 0-12 fibrinogen beta chain Homo sapiens 36-46 33440293-3 2021 In the present study, we show that the biological oxidant hypochlorite promotes the formation of soluble high molecular weight fibrinogen assemblies >=40 x 106 Da, that do not accumulate when fibrinogen is induced to aggregate by other stresses such as heating or hydroxyl-mediated damage in vitro. Hypochlorous Acid 58-70 fibrinogen beta chain Homo sapiens 127-137 33440293-3 2021 In the present study, we show that the biological oxidant hypochlorite promotes the formation of soluble high molecular weight fibrinogen assemblies >=40 x 106 Da, that do not accumulate when fibrinogen is induced to aggregate by other stresses such as heating or hydroxyl-mediated damage in vitro. Hypochlorous Acid 58-70 fibrinogen beta chain Homo sapiens 192-202 33440293-3 2021 In the present study, we show that the biological oxidant hypochlorite promotes the formation of soluble high molecular weight fibrinogen assemblies >=40 x 106 Da, that do not accumulate when fibrinogen is induced to aggregate by other stresses such as heating or hydroxyl-mediated damage in vitro. Hydroxyl Radical 264-272 fibrinogen beta chain Homo sapiens 127-137 33440293-4 2021 Hypochlorite-modified fibrinogen is stable at 37 C as assessed by precipitation assays, and has reduced susceptibility to iron-induced (hydroxyl-mediated) precipitation compared to native fibrinogen. Hypochlorous Acid 0-12 fibrinogen beta chain Homo sapiens 22-32 33440293-4 2021 Hypochlorite-modified fibrinogen is stable at 37 C as assessed by precipitation assays, and has reduced susceptibility to iron-induced (hydroxyl-mediated) precipitation compared to native fibrinogen. Iron 123-127 fibrinogen beta chain Homo sapiens 22-32 33440293-5 2021 In contrast to hypochlorite-modified albumin, which is known to be immunostimulatory, hypochlorite-modified fibrinogen does not induce RAW 264.7 (macrophage-like) cells or EOC 13.31 (microglia-like) cells to produce reactive oxygen species or induce cell death. Hypochlorous Acid 86-98 fibrinogen beta chain Homo sapiens 108-118 33440293-6 2021 Furthermore, depletion of fibrinogen from human blood plasma increases the immunostimulatory property of blood plasma after it is supplemented with hypochlorite in situ. Hypochlorous Acid 148-160 fibrinogen beta chain Homo sapiens 26-36 33440293-7 2021 We propose that reaction of hypochlorite with fibrinogen in blood plasma potentially reduces the accumulation of other hypochlorite-modified species such as immunostimulatory hypochlorite-modified albumin. Hypochlorous Acid 28-40 fibrinogen beta chain Homo sapiens 46-56 33440293-7 2021 We propose that reaction of hypochlorite with fibrinogen in blood plasma potentially reduces the accumulation of other hypochlorite-modified species such as immunostimulatory hypochlorite-modified albumin. Hypochlorous Acid 119-131 fibrinogen beta chain Homo sapiens 46-56 33440293-7 2021 We propose that reaction of hypochlorite with fibrinogen in blood plasma potentially reduces the accumulation of other hypochlorite-modified species such as immunostimulatory hypochlorite-modified albumin. Hypochlorous Acid 119-131 fibrinogen beta chain Homo sapiens 46-56 33788001-7 2021 The vitamin D-deficient group had a significantly higher age and fibrinogen levels while also having a lower lymphocyte count compared to the insufficient and normal groups. Vitamin D 4-13 fibrinogen beta chain Homo sapiens 65-75 33788001-8 2021 The 25 OH vitamin D level was correlated positively with the lymphocyte count (r = 0.375, p = <0.001), and negatively with age (r = -0.496, p = <0.001), CRP (r = -0.309, p = 0.002) and fibrinogen levels (r = -0.381, p = <0.001). Vitamin D 10-19 fibrinogen beta chain Homo sapiens 185-195 33788001-9 2021 In a logistic regression analysis, vitamin D deficiency, D-dimer, and fibrinogen levels on admission were independent predictors of severe clinical course.Conclusion: This study revealed an association between vitamin D deficiency and clinical severity, in addition to inflammation markers in pediatric COVID-19 cases. Vitamin D 210-219 fibrinogen beta chain Homo sapiens 70-80 33980202-9 2021 After adjusted for other clinicopathological factors in the multivariate logistic regression model, low Fib status was strongly associated with pCR to NAC (OR = 3.038, 95% CI 1.667-5.537, P < 0.001). nac 151-154 fibrinogen beta chain Homo sapiens 104-107 33980202-11 2021 CONCLUSIONS: This study demonstrates that low pre-treatment plasma Fib (Fib < 3.435 g/L) is an independent predictive factor for pCR to NAC in breast cancer patients. nac 136-139 fibrinogen beta chain Homo sapiens 67-70 33980202-11 2021 CONCLUSIONS: This study demonstrates that low pre-treatment plasma Fib (Fib < 3.435 g/L) is an independent predictive factor for pCR to NAC in breast cancer patients. nac 136-139 fibrinogen beta chain Homo sapiens 72-75 33980202-12 2021 Moreover, T3-featured breast cancer patients with lower Fib level exhibit better RFS outcomes after NAC compared with high Fib status. nac 100-103 fibrinogen beta chain Homo sapiens 56-59 33187794-0 2021 Dual effects of fibrinogen decoration on the tuning of silica nanoparticles-induced autophagic response: The implication of sedimentation and internalization. Silicon Dioxide 55-61 fibrinogen beta chain Homo sapiens 16-26 33187794-3 2021 Here, we showed that fibrinogen (Fg), but not albumin (BSA) or hemoglobin (Hb), decoration on the surface of silica nanoparticles (SiO2 NPs) ameliorate their pro-autophagic activity in non-phagocytic cells. Silicon Dioxide 109-115 fibrinogen beta chain Homo sapiens 21-31 33187794-3 2021 Here, we showed that fibrinogen (Fg), but not albumin (BSA) or hemoglobin (Hb), decoration on the surface of silica nanoparticles (SiO2 NPs) ameliorate their pro-autophagic activity in non-phagocytic cells. Silicon Dioxide 131-135 fibrinogen beta chain Homo sapiens 21-31 33918684-4 2021 The results revealed that the tested analytes at in vivo relevant levels (1-5 microg/mL) considerably reduced the structural changes in the fibrinogen molecule under the oxidative stress conditions induced by peroxynitrite. Peroxynitrous Acid 209-222 fibrinogen beta chain Homo sapiens 140-150 33918684-7 2021 The study indicated that low molecular weight polyphenols were crucial for the protective activity of the extracts toward fibrinogen and other human plasma components. Polyphenols 46-57 fibrinogen beta chain Homo sapiens 122-132 33752337-0 2021 Fibrinogen, collagen, and transferrin adsorption to poly(3,4-ethylenedioxythiophene)-xylorhamno-uronic glycan composite conducting polymer biomaterials for wound healing applications. poly(3,4-ethylenedioxythiophene)-xylorhamno-uronic glycan 52-109 fibrinogen beta chain Homo sapiens 0-10 33752337-0 2021 Fibrinogen, collagen, and transferrin adsorption to poly(3,4-ethylenedioxythiophene)-xylorhamno-uronic glycan composite conducting polymer biomaterials for wound healing applications. Polymers 131-138 fibrinogen beta chain Homo sapiens 0-10 33826536-8 2021 In groups B and C, atorvastatin use was also associated with a decrease in uric acid, fibrinogen and homocysteine concentrations and with an increase in 25-hydroxyvitamin D levels. Atorvastatin 19-31 fibrinogen beta chain Homo sapiens 86-96 33694259-11 2021 Our results implicate fibrinogen in GBM as a mediator of the invasive properties of BTICs, and as a target for therapy to reduce BTIC tumorigenecity. btics 84-89 fibrinogen beta chain Homo sapiens 22-32 33395250-3 2021 In this proof-of-concept study, we sought to prepare a fibrin-targeting magnetic resonance imaging contrast agent, using a Gd(III)-loaded fibrinogen aptamer (FA) chelate conjugate (Gd(III)-NOTA-FA) (NOTA = 1,4,7-triazacyclononane-1,4,7-triacetic acid), to endow the ability to specifically accumulate at the location of blood clots, thereby enhancing contrast capabilities. (iii)-nota-fa 183-196 fibrinogen beta chain Homo sapiens 138-148 33352490-1 2021 An excellent blood-compatible polymer, poly(2-methoxyethyl acrylate) (PMEA), exhibits nanometer-scale phase-separated structures at the interface with water or phosphate-buffered saline (PBS), and fibrinogen adsorption is suppressed, especially on the water-rich region. Polymers 30-37 fibrinogen beta chain Homo sapiens 197-207 33352490-1 2021 An excellent blood-compatible polymer, poly(2-methoxyethyl acrylate) (PMEA), exhibits nanometer-scale phase-separated structures at the interface with water or phosphate-buffered saline (PBS), and fibrinogen adsorption is suppressed, especially on the water-rich region. poly(2-methoxyethylacrylate) 39-68 fibrinogen beta chain Homo sapiens 197-207 33352490-1 2021 An excellent blood-compatible polymer, poly(2-methoxyethyl acrylate) (PMEA), exhibits nanometer-scale phase-separated structures at the interface with water or phosphate-buffered saline (PBS), and fibrinogen adsorption is suppressed, especially on the water-rich region. poly(2-methoxyethylacrylate) 70-74 fibrinogen beta chain Homo sapiens 197-207 33360080-10 2021 Additionally, fibrinogen adsorption and platelet adhesion were effectively suppressed based on the characteristics of the phosphorylcholine unit. Phosphorylcholine 122-139 fibrinogen beta chain Homo sapiens 14-24 33548450-0 2021 Identification and relative quantification of 3-nitrotyrosine residues in fibrinogen nitrated in vitro and fibrinogen from ischemic stroke patient plasma using LC-MS/MS. 3-nitrotyrosine 46-61 fibrinogen beta chain Homo sapiens 74-84 33548450-3 2021 Fibrinogen is one of the most abundant plasma proteins; it plays a role in the hemostatic system, mediating clot formation, which can be affected by nitrotyrosine formation. 3-nitrotyrosine 149-162 fibrinogen beta chain Homo sapiens 0-10 33548450-4 2021 We hypothesized that nitration of fibrinogen by ONOOH and ONOOCO2- radical products could be one of the early events of the ischemic stroke, and protein-bound 3-nitrotyrosine could be a potential biomarker for diagnosis and/or prognosis of this condition. onooh 48-53 fibrinogen beta chain Homo sapiens 34-44 33548450-4 2021 We hypothesized that nitration of fibrinogen by ONOOH and ONOOCO2- radical products could be one of the early events of the ischemic stroke, and protein-bound 3-nitrotyrosine could be a potential biomarker for diagnosis and/or prognosis of this condition. onooco2- radical 58-74 fibrinogen beta chain Homo sapiens 34-44 33548450-7 2021 Twenty different 3-nitrotyrosine residues were identified on fibrinogen nitrated in vitro, varying with the peroxynitrite: fibrinogen molar ratio used. 3-nitrotyrosine 17-32 fibrinogen beta chain Homo sapiens 61-71 33548450-7 2021 Twenty different 3-nitrotyrosine residues were identified on fibrinogen nitrated in vitro, varying with the peroxynitrite: fibrinogen molar ratio used. 3-nitrotyrosine 17-32 fibrinogen beta chain Homo sapiens 123-133 33548450-12 2021 Different tyrosine nitration patterns were also observed in fibrinogen modified in vitro and in vivo, suggesting differences in the nitration process in these situations. Tyrosine 10-18 fibrinogen beta chain Homo sapiens 60-70 33548450-13 2021 This is the first study showing a putative association between the nitration profile of specific tyrosine residues in human fibrinogen and ischemic stroke. Tyrosine 97-105 fibrinogen beta chain Homo sapiens 124-134 33411219-6 2021 Thrombin is a serine protease capable of cleaving multiple substrates, including protease activated receptors (PARs), fibrinogen, and protein C. Cleavage of all three of these substrates represent pathways through which thrombin activity may exert immuno-regulatory effects and regulate permeability of the BBB during MS and EAE. Serine 14-20 fibrinogen beta chain Homo sapiens 118-128 33837899-9 2021 Fibrinogen is an independent predictor of resistance to heparin and should be considered before thromboprophylaxis. Heparin 56-63 fibrinogen beta chain Homo sapiens 0-10 33834609-6 2021 PGI2 significantly reduced fibrinogen binding and prevented the majority of PS exposure, but did not significantly reduce CD62P, CD154 or CD63 leading to the generation of four novel subpopulations, CD62Phi /PSlo /fblo (64%), CD62Phi /PSlo /fbhi (22%), CD62Phi /PShi /fblo (3%), and CD62Plo /PSlo /fblo (12%). Epoprostenol 0-4 fibrinogen beta chain Homo sapiens 27-37 33578732-6 2021 The structure-function correlations determined by combining modeling/docking strategies with quantitative in vitro assays revealed spatial overlap of the FA12 binding site with the binding sites of two FXIII substrates, fibrinogen and alpha2AP, while FA2 binding sites only overlap those of fibrinogen. fa12 154-158 fibrinogen beta chain Homo sapiens 220-230 33578732-6 2021 The structure-function correlations determined by combining modeling/docking strategies with quantitative in vitro assays revealed spatial overlap of the FA12 binding site with the binding sites of two FXIII substrates, fibrinogen and alpha2AP, while FA2 binding sites only overlap those of fibrinogen. fa12 154-158 fibrinogen beta chain Homo sapiens 291-301 33557943-7 2021 The agonists-stimulated Dab2-pSer24 was attenuated by pretreatment of platelets with the RGDS peptide which inhibits integrin outside-in signaling by competitive binding of integrin alphaIIb with fibrinogen. pser24 29-35 fibrinogen beta chain Homo sapiens 196-206 33503095-0 2021 Single-particle fibrinogen detection using platelet membrane-coated fluorescent polystyrene nanoparticles. Polystyrenes 80-91 fibrinogen beta chain Homo sapiens 16-26 33503095-3 2021 Herein, we demonstrate a new color-coded single-particle detection (SPD) method for fibrinogen detection by using platelet membrane-coated fluorescent polystyrene nanoparticles (PNPs) as the probes. Polystyrenes 151-162 fibrinogen beta chain Homo sapiens 84-94 33544272-5 2021 Interestingly, loss of GA-5 signal in sub-meningeal white matter was strongly associated with vascular disruption as defined by extravascular fibrinogen leak and by glio-vascular uncoupling, as defined by dissociation of AQP4-positive astrocyte endfeet and CD31-positive blood vessels. Gallium 23-25 fibrinogen beta chain Homo sapiens 142-152 33276061-0 2021 Thermal shift assay to probe melting of thrombin, fibrinogen, fibrin monomer, and fibrin: Gly-Pro-Arg-Pro induces a fibrin monomer-like state in fibrinogen. glycyl-prolyl-arginyl-proline 90-105 fibrinogen beta chain Homo sapiens 145-155 33276061-4 2021 RESULTS: Large increases in Tm indicated that calcium led to protein stabilization (0 vs. 2 mM Ca2+) for fibrinogen (54.0 vs. 62.3 C) and fibrin (62.3 vs. 72.2 C). Calcium 46-53 fibrinogen beta chain Homo sapiens 105-115 32696349-6 2021 In group 2, atorvastatin exerted also a more potent impact on hsCRP, fibrinogen and homocysteine. Atorvastatin 12-24 fibrinogen beta chain Homo sapiens 69-79 33307284-1 2021 Acetylsalicylic acid (ASA) and type 2 diabetes mellitus (T2DM) affect fibrin clot properties through fibrinogen acetylation or glycation. Aspirin 0-20 fibrinogen beta chain Homo sapiens 101-111 33307284-1 2021 Acetylsalicylic acid (ASA) and type 2 diabetes mellitus (T2DM) affect fibrin clot properties through fibrinogen acetylation or glycation. Aspirin 22-25 fibrinogen beta chain Homo sapiens 101-111 33307284-2 2021 We aimed to identify glycation and acetylation sites on fibrinogen in plasma fibrin clot of T2DM patients with respect to effects of ASA and fibrin clot properties. Aspirin 133-136 fibrinogen beta chain Homo sapiens 56-66 33526243-3 2021 There are limited data on the effect of dabigatran on some fibrinogen measurements and on D-dimer assays, both important components in the laboratory assessment of disseminated intravascular coagulation (DIC). Dabigatran 40-50 fibrinogen beta chain Homo sapiens 59-69 33526243-11 2021 Like the routine coagulation assays, there is a dabigatran concentration dependent effect on the accuracy of fibrinogen and D-dimer assays. Dabigatran 48-58 fibrinogen beta chain Homo sapiens 109-119 33526243-12 2021 Falsely low fibrinogen results due to dabigatran may confound the assessment of DIC and diagnostic laboratories need to evaluate the performance of their own reagents. Dabigatran 38-48 fibrinogen beta chain Homo sapiens 12-22 33828014-5 2021 Monitoring of the fibrinogen levels, especially during the first course of steroid therapy, would be useful for early diagnosis. Steroids 75-82 fibrinogen beta chain Homo sapiens 18-28 33075564-3 2021 METHOD: Fibrinogen level was measured in dextran sulphate sodium (DSS)-induced colitis and patients with ulcerative colitis. dextran sulphate sodium 41-64 fibrinogen beta chain Homo sapiens 8-18 33075564-3 2021 METHOD: Fibrinogen level was measured in dextran sulphate sodium (DSS)-induced colitis and patients with ulcerative colitis. dss 66-69 fibrinogen beta chain Homo sapiens 8-18 33075564-6 2021 RESULTS: Through Tandem Mass Tag (TMT)-based quantitative proteomics, fibrinogen (Fg) was found to be upregulated in the colon of DSS-treated mice, which was consistent with increased Fg level in colon sample of patients with ulcerative colitis. dss 130-133 fibrinogen beta chain Homo sapiens 70-80 33245842-0 2021 Afibrinogenemia caused by a novel homozygous missense mutation, FGB p.Cys241Tyr, in a male patient with recurrent intracranial bleeding: case report and review of literature. cys241tyr 70-79 fibrinogen beta chain Homo sapiens 64-67 33245842-5 2021 RESULT: Molecular analysis revealed a novel homozygous missense mutation in FGB exon 5, p.Cys241 Tyr, that was named "Fibrinogen Krakow V". Tyrosine 97-100 fibrinogen beta chain Homo sapiens 76-79 33245842-5 2021 RESULT: Molecular analysis revealed a novel homozygous missense mutation in FGB exon 5, p.Cys241 Tyr, that was named "Fibrinogen Krakow V". Tyrosine 97-100 fibrinogen beta chain Homo sapiens 118-128 33255056-2 2021 The arginine-glycine-aspartic acid (RGD) sequence is present in several ECM proteins, such as fibronectin, collagen type I, fibrinogen, laminin, vitronectin, and osteopontin. arginine-glycine 4-20 fibrinogen beta chain Homo sapiens 124-134 33255056-2 2021 The arginine-glycine-aspartic acid (RGD) sequence is present in several ECM proteins, such as fibronectin, collagen type I, fibrinogen, laminin, vitronectin, and osteopontin. Aspartic Acid 21-34 fibrinogen beta chain Homo sapiens 124-134 32777331-2 2021 TBA - also named HD1, a 15-mer G-quadruplex (G4)-forming oligonucleotide - is the best characterized thrombin binding aptamer, able to specifically recognize the protein exosite I, thus inhibiting the conversion of soluble fibrinogen into insoluble fibrin strands. Oligonucleotides 57-72 fibrinogen beta chain Homo sapiens 223-233 33536895-8 2020 Results: Gender, NIHSS, and FIB showed significant differences among the vitamin D groups (P < 0.001 ~ P = 0.002). Vitamin D 73-82 fibrinogen beta chain Homo sapiens 28-31 33536895-11 2020 Conclusions: The female gender, severity of stroke using NIHSS and FIB were risk factors for vitamin D deficiency in our incident stroke patients. Vitamin D 93-102 fibrinogen beta chain Homo sapiens 67-70 33536895-13 2020 Besides, under higher FIB circumstance, the increasing NIHSS score was more related to the vitamin D deficiency. Vitamin D 91-100 fibrinogen beta chain Homo sapiens 22-25 33360096-4 2021 The increase in diffusion time between free and fibrinogen-bound FITC-labelled FcRn was assumed as the binding indicator. Fluorescein-5-isothiocyanate 65-69 fibrinogen beta chain Homo sapiens 48-58 32809062-10 2021 Postpartum tranexamic acid oral dosage should be discussed when fibrinogen levels are decreasing and D-Dimers are increasing. Tranexamic Acid 11-26 fibrinogen beta chain Homo sapiens 64-74 33196514-12 2021 Despite decreased fibrinogen levels after on-pump CABG with tranexamic acid, fibrin clot susceptibility to lysis is impaired, as reflected by prolonged CLT. Tranexamic Acid 60-75 fibrinogen beta chain Homo sapiens 18-28 33001565-6 2021 METHODS: We characterized effects of plasminogen, tissue plasminogen activator, fibrinogen, and alpha2 -antiplasmin on PG in vitro. pg 119-121 fibrinogen beta chain Homo sapiens 80-90 33376233-12 2020 To the best of our knowledge, this is the first case report of spontaneous systemic bleeding due to valproic acid-induced thrombocytopenia in the setting of normal fibrinogen levels. Valproic Acid 100-113 fibrinogen beta chain Homo sapiens 164-174 32827201-10 2020 Targeting PI and fibrinogen, by reducing metabolic variables such as glucose, cholesterol and IL-6, has a profibrinolytic effect in obesity. Glucose 69-76 fibrinogen beta chain Homo sapiens 17-27 32827201-10 2020 Targeting PI and fibrinogen, by reducing metabolic variables such as glucose, cholesterol and IL-6, has a profibrinolytic effect in obesity. Cholesterol 78-89 fibrinogen beta chain Homo sapiens 17-27 32228225-5 2020 Identified mutations were confirmed by Sanger sequencing.Results: We have identified a novel heterozygous FGB c.560_561delTG (p.Val187GlufsTer2) frameshift deletion and a novel heterozygous FGA c.190T > G (p.Cys64Gly) missense mutations in a Chinese patient with CFD.Conclusion: This is the first report of digenic variants causing CFD, and these findings may improve understanding of the genetic architecture of CFD. cys64gly 208-216 fibrinogen beta chain Homo sapiens 106-109 32860258-7 2020 Compared with before treatment, fibrinogen (FIB) significantly decreased after tigecycline was used while prothrombin time (PT), activated partial thromboplastin time (APTT) and thrombin time (TT) significantly increased (all P < .001). Tigecycline 79-90 fibrinogen beta chain Homo sapiens 32-42 32860258-7 2020 Compared with before treatment, fibrinogen (FIB) significantly decreased after tigecycline was used while prothrombin time (PT), activated partial thromboplastin time (APTT) and thrombin time (TT) significantly increased (all P < .001). Tigecycline 79-90 fibrinogen beta chain Homo sapiens 44-47 32812374-4 2020 PEO-SA modified PUs are evaluated for their mechanical properties, water-driven surface restructuring, and adhesion resistance against a human fibrinogen (HF) solution as well as whole human blood. peo-sa 0-6 fibrinogen beta chain Homo sapiens 143-153 33291690-4 2020 The blood clotting protein, fibrinogen, and the protease inhibitor, alpha2-macroglobulin, exist in multiple disulfide-bonded or covalent states in the circulation. Disulfides 108-117 fibrinogen beta chain Homo sapiens 28-38 32919662-5 2020 The in situ SR-muCT showed that fibrinogen adsorption and membrane fouling were intense on PES membrane surface. polyether sulfone 91-94 fibrinogen beta chain Homo sapiens 32-42 32919662-8 2020 The spectral features indicate that PES-ZW surface has a lower adsorption affinity for fibrinogen than that for the PES surface. polyether sulfone 36-39 fibrinogen beta chain Homo sapiens 87-97 32919662-11 2020 Docking studies thus suggest that the membrane"s sulfone functional groups play an essential key role during the fibrinogen interaction and adsorption. Sulfones 49-56 fibrinogen beta chain Homo sapiens 113-123 32919662-13 2020 This study"s results emphasize that even though a neutral charge of synthesized novel zwitterion PES, which enhances biocompatibility, the sulfone group still significantly affected the interactions with fibrinogen. Sulfones 139-146 fibrinogen beta chain Homo sapiens 204-214 33292263-0 2020 The association of alcohol with circulating total fibrinogen and plasma clot density is mediated by fibrinogen and FXIII genotypes. Alcohols 19-26 fibrinogen beta chain Homo sapiens 50-60 33292263-0 2020 The association of alcohol with circulating total fibrinogen and plasma clot density is mediated by fibrinogen and FXIII genotypes. Alcohols 19-26 fibrinogen beta chain Homo sapiens 100-110 33292263-5 2020 RESULTS: Alcohol intake and its markers correlated negatively with fibrinogen and clot lysis time (CLT) as well as with most of the clot properties. Alcohols 9-16 fibrinogen beta chain Homo sapiens 67-77 33292263-6 2020 Percentage gamma" fibrinogen correlated positively with AST and negatively with alcohol intake. Alcohols 80-87 fibrinogen beta chain Homo sapiens 18-28 33292263-7 2020 We then stratified for alcohol intake and found inverse associations between gamma" fibrinogen and both %CDT and GGT-CDT in consumers, but the positive association with AST remained only in abstainers. Alcohols 23-30 fibrinogen beta chain Homo sapiens 84-94 33292263-7 2020 We then stratified for alcohol intake and found inverse associations between gamma" fibrinogen and both %CDT and GGT-CDT in consumers, but the positive association with AST remained only in abstainers. 1,5,9-cyclododecatriene 105-108 fibrinogen beta chain Homo sapiens 84-94 33292263-7 2020 We then stratified for alcohol intake and found inverse associations between gamma" fibrinogen and both %CDT and GGT-CDT in consumers, but the positive association with AST remained only in abstainers. 1,5,9-cyclododecatriene 117-120 fibrinogen beta chain Homo sapiens 84-94 33292263-8 2020 Alcohol intake and its markers modulated the influence of fibrinogen SNPs on total fibrinogen concentrations and the fibrinogen SNPs as well as an FXIII SNP on clot density (all p < 0.004). Alcohols 0-7 fibrinogen beta chain Homo sapiens 58-68 33292263-8 2020 Alcohol intake and its markers modulated the influence of fibrinogen SNPs on total fibrinogen concentrations and the fibrinogen SNPs as well as an FXIII SNP on clot density (all p < 0.004). Alcohols 0-7 fibrinogen beta chain Homo sapiens 83-93 33292263-8 2020 Alcohol intake and its markers modulated the influence of fibrinogen SNPs on total fibrinogen concentrations and the fibrinogen SNPs as well as an FXIII SNP on clot density (all p < 0.004). Alcohols 0-7 fibrinogen beta chain Homo sapiens 83-93 33244022-1 2020 In this study, we investigated how carbonylation of fibrinogen by acrolein modified its indispensable function to enhance fibrinolysis after being converted to fibrin and contributed to generating a fibrinolysis-resistant fibrin clot. Acrolein 66-74 fibrinogen beta chain Homo sapiens 52-62 33244022-2 2020 Acrolein-treated fibrinogen was subjected to tissue plasminogen activator-induced fibrinolysis assay and the effect of lysine residue carbonylation in fibrinogen on fibrinolysis was analyzed. Acrolein 0-8 fibrinogen beta chain Homo sapiens 17-27 33244022-2 2020 Acrolein-treated fibrinogen was subjected to tissue plasminogen activator-induced fibrinolysis assay and the effect of lysine residue carbonylation in fibrinogen on fibrinolysis was analyzed. Lysine 119-125 fibrinogen beta chain Homo sapiens 151-161 33244022-3 2020 The acrolein-treated fibrinogen-derived fibrin clot appeared more resistant to fibrinolysis and the N-acetyl 3-formyl-3,4-dehydropiperidino (FDP)-Lysine levels in the lysed solution were positively correlated with the duration of clot lysis. Acrolein 4-12 fibrinogen beta chain Homo sapiens 21-31 33244022-3 2020 The acrolein-treated fibrinogen-derived fibrin clot appeared more resistant to fibrinolysis and the N-acetyl 3-formyl-3,4-dehydropiperidino (FDP)-Lysine levels in the lysed solution were positively correlated with the duration of clot lysis. n-acetyl 3-formyl-3,4-dehydropiperidino 100-139 fibrinogen beta chain Homo sapiens 21-31 33244022-3 2020 The acrolein-treated fibrinogen-derived fibrin clot appeared more resistant to fibrinolysis and the N-acetyl 3-formyl-3,4-dehydropiperidino (FDP)-Lysine levels in the lysed solution were positively correlated with the duration of clot lysis. fdp 141-144 fibrinogen beta chain Homo sapiens 21-31 33244022-3 2020 The acrolein-treated fibrinogen-derived fibrin clot appeared more resistant to fibrinolysis and the N-acetyl 3-formyl-3,4-dehydropiperidino (FDP)-Lysine levels in the lysed solution were positively correlated with the duration of clot lysis. Lysine 146-152 fibrinogen beta chain Homo sapiens 21-31 33244022-6 2020 These results suggest that fibrinogen carbonylation by acrolein to generate N-acetyl FDP-Lysine resulted in the generation of fibrinolysis-resistant fibrin by attenuating the C-terminal lysine-dependent activation of the Glu1-plasminogen. Acrolein 55-63 fibrinogen beta chain Homo sapiens 27-37 33244022-6 2020 These results suggest that fibrinogen carbonylation by acrolein to generate N-acetyl FDP-Lysine resulted in the generation of fibrinolysis-resistant fibrin by attenuating the C-terminal lysine-dependent activation of the Glu1-plasminogen. n-acetyl fdp-lysine 76-95 fibrinogen beta chain Homo sapiens 27-37 33244022-6 2020 These results suggest that fibrinogen carbonylation by acrolein to generate N-acetyl FDP-Lysine resulted in the generation of fibrinolysis-resistant fibrin by attenuating the C-terminal lysine-dependent activation of the Glu1-plasminogen. Lysine 186-192 fibrinogen beta chain Homo sapiens 27-37 33238433-8 2020 Platelet fibrinogen binding was dose-dependently induced by the C-terminal thrombospondin-1 peptide RFYVVMWK, Eap or NaSCN-treated IgG, but diminished in the presence of plasmin. sodium thiocyanate 117-122 fibrinogen beta chain Homo sapiens 9-19 33284518-0 2021 Anti-Platelet Effect Induced by Iron Oxide Nanoparticles: Correlation with Conformational Change in Fibrinogen. ferric oxide 32-42 fibrinogen beta chain Homo sapiens 100-110 33244162-5 2020 Water-soluble fibrinogen, following cleavage by thrombin, self-polymerize to form water-insoluble fibrin. Water 0-5 fibrinogen beta chain Homo sapiens 14-24 33244162-5 2020 Water-soluble fibrinogen, following cleavage by thrombin, self-polymerize to form water-insoluble fibrin. Water 82-87 fibrinogen beta chain Homo sapiens 14-24 33228181-1 2020 In this work, one of the most prevalent polypharmacology drug-drug interaction events that occurs between two widely used beta-blocker drugs-i.e., acebutolol and propranolol-with the most abundant blood plasma fibrinogen protein was evaluated. Acebutolol 147-157 fibrinogen beta chain Homo sapiens 210-220 33228181-1 2020 In this work, one of the most prevalent polypharmacology drug-drug interaction events that occurs between two widely used beta-blocker drugs-i.e., acebutolol and propranolol-with the most abundant blood plasma fibrinogen protein was evaluated. Propranolol 162-173 fibrinogen beta chain Homo sapiens 210-220 32653381-0 2020 Mapping the underlying mechanisms of fibrinogen benzothiazole drug interactions using computational and experimental approaches. benzothiazole 48-61 fibrinogen beta chain Homo sapiens 37-47 33184146-14 2022 Fibrinogen levels significantly decreased with cholecalciferol supplementation (intergroup difference 0.70 ng/ml; P=0.007) unlike other inflammatory biomarkers. Cholecalciferol 47-62 fibrinogen beta chain Homo sapiens 0-10 33184146-15 2022 CONCLUSION: Greater proportion of vitamin D-deficient individuals with SARS-CoV-2 infection turned SARS-CoV-2 RNA negative with a significant decrease in fibrinogen on high-dose cholecalciferol supplementation. Vitamin D 34-43 fibrinogen beta chain Homo sapiens 154-164 33184146-15 2022 CONCLUSION: Greater proportion of vitamin D-deficient individuals with SARS-CoV-2 infection turned SARS-CoV-2 RNA negative with a significant decrease in fibrinogen on high-dose cholecalciferol supplementation. Cholecalciferol 178-193 fibrinogen beta chain Homo sapiens 154-164 32472302-0 2020 Autoantibodies against a novel citrullinated fibrinogen peptide related to smoking status, disease activity and therapeutic response to methotrexate in cuban patients with early rheumatoid arthritis. Methotrexate 136-148 fibrinogen beta chain Homo sapiens 45-55 32772348-5 2020 Addition of fibrinogen restored in vitro thrombus formation in the presence of antiplatelet drugs and heparin. Heparin 102-109 fibrinogen beta chain Homo sapiens 12-22 33122656-2 2020 Here, we test this assumption by quantifying the redox state of disulfide bonds in the blood clotting protein fibrinogen. Disulfides 64-73 fibrinogen beta chain Homo sapiens 110-120 33122656-3 2020 The disulfide status of fibrinogen from healthy human donor plasma and cultured human hepatocytes are measured using differential cysteine alkylation and mass spectrometry. Disulfides 4-13 fibrinogen beta chain Homo sapiens 24-34 33122656-3 2020 The disulfide status of fibrinogen from healthy human donor plasma and cultured human hepatocytes are measured using differential cysteine alkylation and mass spectrometry. Cysteine 130-138 fibrinogen beta chain Homo sapiens 24-34 33122656-4 2020 This analysis identifies 13 disulfide bonds that are 10-50% reduced, indicating that fibrinogen is produced in multiple disulfide-bonded or covalent states. Disulfides 28-37 fibrinogen beta chain Homo sapiens 85-95 33122656-4 2020 This analysis identifies 13 disulfide bonds that are 10-50% reduced, indicating that fibrinogen is produced in multiple disulfide-bonded or covalent states. Disulfides 120-129 fibrinogen beta chain Homo sapiens 85-95 33120753-5 2020 The decrease in fibrinogen occurred within 3 to 7 days of tigecycline treatment. Tigecycline 58-69 fibrinogen beta chain Homo sapiens 16-26 33120753-9 2020 OUTCOMES: The fibrinogen level normalized within 5 days after the withdrawal of tigecycline. Tigecycline 80-91 fibrinogen beta chain Homo sapiens 14-24 32986054-5 2020 In this study, we report on maghemite nanoparticles functionalized with citrate-, dextran- and polyethylene glycol coatings and their interaction with the clotting protein fibrinogen. ferric oxide 28-37 fibrinogen beta chain Homo sapiens 172-182 32986054-5 2020 In this study, we report on maghemite nanoparticles functionalized with citrate-, dextran- and polyethylene glycol coatings and their interaction with the clotting protein fibrinogen. Citric Acid 72-79 fibrinogen beta chain Homo sapiens 172-182 32986054-5 2020 In this study, we report on maghemite nanoparticles functionalized with citrate-, dextran- and polyethylene glycol coatings and their interaction with the clotting protein fibrinogen. Dextrans 82-89 fibrinogen beta chain Homo sapiens 172-182 32986054-5 2020 In this study, we report on maghemite nanoparticles functionalized with citrate-, dextran- and polyethylene glycol coatings and their interaction with the clotting protein fibrinogen. Polyethylene Glycols 95-114 fibrinogen beta chain Homo sapiens 172-182 32986054-8 2020 In addition, bioconjugates of fibrinogen with dextran- and citrate-coated NPs interact with integrin-containing lipid bilayer, especially upon treatment with divalent ions, whereas PEG-coating reveals minor interaction. Dextrans 46-53 fibrinogen beta chain Homo sapiens 30-40 32986054-8 2020 In addition, bioconjugates of fibrinogen with dextran- and citrate-coated NPs interact with integrin-containing lipid bilayer, especially upon treatment with divalent ions, whereas PEG-coating reveals minor interaction. Citric Acid 59-66 fibrinogen beta chain Homo sapiens 30-40 32986054-8 2020 In addition, bioconjugates of fibrinogen with dextran- and citrate-coated NPs interact with integrin-containing lipid bilayer, especially upon treatment with divalent ions, whereas PEG-coating reveals minor interaction. Polyethylene Glycols 181-184 fibrinogen beta chain Homo sapiens 30-40 32693110-10 2020 Neutrophil adherent to fibrinogen, but not to polylysine, were able to produce ROS upon lipopolysaccharide challenge and ROS production was completely suppressed upon inhibition of Pyk2. ros 79-82 fibrinogen beta chain Homo sapiens 23-33 32693110-10 2020 Neutrophil adherent to fibrinogen, but not to polylysine, were able to produce ROS upon lipopolysaccharide challenge and ROS production was completely suppressed upon inhibition of Pyk2. ros 121-124 fibrinogen beta chain Homo sapiens 23-33 32693110-11 2020 By contrast PMA-induced ROS production by neutrophil adherent to either fibrinogen or polylysine was independent from Pyk2. Tetradecanoylphorbol Acetate 12-15 fibrinogen beta chain Homo sapiens 72-82 32693110-11 2020 By contrast PMA-induced ROS production by neutrophil adherent to either fibrinogen or polylysine was independent from Pyk2. ros 24-27 fibrinogen beta chain Homo sapiens 72-82 33245651-6 2020 The penetration of CO2 into the sample leads to changes in the parameters of PTT and APPT, as well as to decrease the protein C and fibrinogen level under certain conditions. Carbon Dioxide 19-22 fibrinogen beta chain Homo sapiens 132-142 33564369-1 2020 Objective: To study the serum levels of fibrinogen and d-dimer in patients with obstructive sleep apnea (OSA) and its correlation with apnea hypopnea index (AHI), oxygen desaturation index (ODI), minimal oxygen saturation and arousal index. Oxygen 163-169 fibrinogen beta chain Homo sapiens 40-50 33564369-1 2020 Objective: To study the serum levels of fibrinogen and d-dimer in patients with obstructive sleep apnea (OSA) and its correlation with apnea hypopnea index (AHI), oxygen desaturation index (ODI), minimal oxygen saturation and arousal index. Oxygen 204-210 fibrinogen beta chain Homo sapiens 40-50 33564369-5 2020 Serum fibrinogen co-related positively with AHI (r=0.6381, p=0.0011) and ODI (r=0.7434, p=0.0000), negatively with minimal oxygen saturation (r=-0.4461, p=0.0329). Oxygen 123-129 fibrinogen beta chain Homo sapiens 6-16 32803122-7 2020 Results In contrast to room temperature, ADP-induced aggregation was maintained under cold storage for 6 days, associated with elevated activation markers like fibrinogen binding or CD62P expression. Adenosine Diphosphate 42-45 fibrinogen beta chain Homo sapiens 161-171 32784866-5 2020 The distribution of glycans on individual chains was also affected, with the gamma chain, responsible for physiological functions of fibrinogen (such as coagulation and platelet aggregation), being most prone to these alterations. Polysaccharides 20-27 fibrinogen beta chain Homo sapiens 133-143 32784866-7 2020 Consequently, investigation of fibrinogen glycans can offer better insight into fibrinogen-related complications observed in ESRD-PD patients and, additionally, contribute to prognosis, choice of personalised therapy, determination of peritoneal membrane damage, and the length of utilization of peritoneum for dialysis. Polysaccharides 42-49 fibrinogen beta chain Homo sapiens 31-41 32688091-2 2020 The hypothesis behind this work was that fibrinogen (Fg) and magnesium (Mg) biomaterials, used in combination (FgMg) could act synergistically to modulate macrophage activation, promoting a pro-regenerative phenotype. Magnesium 72-74 fibrinogen beta chain Homo sapiens 41-51 32688091-2 2020 The hypothesis behind this work was that fibrinogen (Fg) and magnesium (Mg) biomaterials, used in combination (FgMg) could act synergistically to modulate macrophage activation, promoting a pro-regenerative phenotype. fgmg 111-115 fibrinogen beta chain Homo sapiens 41-51 32688091-2 2020 The hypothesis behind this work was that fibrinogen (Fg) and magnesium (Mg) biomaterials, used in combination (FgMg) could act synergistically to modulate macrophage activation, promoting a pro-regenerative phenotype. fgmg 111-115 fibrinogen beta chain Homo sapiens 53-55 32656942-6 2020 Subsequently, a polycaprolactone (PCL)-reinforced porcine blood-derived fibrinogen scaffold (isolated using the same protocol as cord blood fibrinogen) was used to develop a rolled-sheet graft which employed topographical and biochemical guidance cues to promote elastogenesis and cellular orientation. polycaprolactone 16-32 fibrinogen beta chain Homo sapiens 72-82 32656942-6 2020 Subsequently, a polycaprolactone (PCL)-reinforced porcine blood-derived fibrinogen scaffold (isolated using the same protocol as cord blood fibrinogen) was used to develop a rolled-sheet graft which employed topographical and biochemical guidance cues to promote elastogenesis and cellular orientation. polycaprolactone 34-37 fibrinogen beta chain Homo sapiens 72-82 32838617-4 2021 Thrombin/fibrinogen-induced exosome and microvesicle generation was inhibited by miR-223-3p transfection, and this effect was reversed with a RISC inhibitor. mir-223-3p 81-91 fibrinogen beta chain Homo sapiens 9-19 32772827-0 2021 An in vitro approach to unveil the structural alterations in d-ribose induced glycated fibrinogen. Ribose 61-69 fibrinogen beta chain Homo sapiens 87-97 32772827-5 2021 Therefore, it was designed as an in vitro study to elucidate d-ribose mediated glycative damage suffered by fibrinogen protein at secondary and tertiary structure level. Ribose 61-69 fibrinogen beta chain Homo sapiens 108-118 32772827-9 2021 Structural alterations, increased ketoamines, protein carbonyls and HMF contents were reported in d-ribose glycated fibrinogen against their native analogues. ketoamines 34-44 fibrinogen beta chain Homo sapiens 116-126 32772827-9 2021 Structural alterations, increased ketoamines, protein carbonyls and HMF contents were reported in d-ribose glycated fibrinogen against their native analogues. Ribose 98-106 fibrinogen beta chain Homo sapiens 116-126 32772827-11 2021 Thus, we can conclude that under diabetes induced hyperglycemic state in physiological systems, d-ribose induced fibrinogen glycation might play a crucial role in the onset of micro- and macro-vascular complications, thereby worsen the diabetes associated secondary disorders. Ribose 96-104 fibrinogen beta chain Homo sapiens 113-123