PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
20946875-6	2010	Both interactions are mediated by the SH3 domains of ITSN1 and proline-rich motifs of protein partners.	Proline	63-70	intersectin 1	Homo sapiens	53-58
19166927-3	2009	The interaction is mediated by the SH3A domain of ITSN1 and the third or fourth proline-rich blocks of Ruk/CIN85, and does not depend on epidermal growth factor stimulation, suggesting a constitutive association of ITSN1 with Ruk/CIN85.	Proline	80-87	intersectin 1	Homo sapiens	215-220
11381094-5	2001	These interactions occur via two NPF motifs in the proline-rich domain of stonin 2 and Eps15 homology domains of Eps15, Eps15R, and intersectin 1.	Proline	51-58	intersectin 1	Homo sapiens	132-145
17405881-5	2007	ITSN-1 knockdown acts as a proapoptotic signal that causes mitochondrial outer membrane permeabilization, dissipation of the mitochondrial membrane potential, and generation of reactive oxygen species.	Reactive Oxygen Species	177-200	intersectin 1	Homo sapiens	0-6
12686614-0	2003	Intersectin 1L guanine nucleotide exchange activity is regulated by adjacent src homology 3 domains that are also involved in endocytosis.	Guanine Nucleotides	15-33	intersectin 1	Homo sapiens	0-13
32780150-0	2021	ITSN1 regulates SAM68 solubility through SH3 domain interactions with SAM68 proline-rich motifs.	Proline	76-83	intersectin 1	Homo sapiens	0-5
3011536-1	1986	Its N epsilon-acetylated lysine derivative.	Lysine	25-31	intersectin 1	Homo sapiens	0-5
32780150-2	2021	We found that intersectin 1 (ITSN1), a multidomain scaffold protein harboring five soluble SH3 domains, interacts with SAM68 proline-rich motifs (PRMs) surrounded by self-adhesive low complexity domains.	Proline	125-132	intersectin 1	Homo sapiens	14-27
32780150-2	2021	We found that intersectin 1 (ITSN1), a multidomain scaffold protein harboring five soluble SH3 domains, interacts with SAM68 proline-rich motifs (PRMs) surrounded by self-adhesive low complexity domains.	Proline	125-132	intersectin 1	Homo sapiens	29-34
32780150-4	2021	In HeLa cells, the interaction between the first ITSN1 SH3 domain (SH3A) and P0, the N-terminal PRM of SAM68, induces the dissociation of SNBs.	snbs	138-142	intersectin 1	Homo sapiens	49-54
31663854-4	2019	In the present work, we uncover a mechanism mediating an increased SV clustering through the interaction of VGLUT1 second proline-rich domain, endophilinA1 and intersectin1.	isoleucyl-prolyl-proline	122-129	intersectin 1	Homo sapiens	160-172
33248053-0	2021	Atractylodis macrocephalae polysaccharides protect against DSS-induced intestinal injury through a novel lncRNA ITSN1-OT1.	atractylodis macrocephalae polysaccharides	0-42	intersectin 1	Homo sapiens	112-117
33248053-0	2021	Atractylodis macrocephalae polysaccharides protect against DSS-induced intestinal injury through a novel lncRNA ITSN1-OT1.	Dextran Sulfate	59-62	intersectin 1	Homo sapiens	112-117
33248053-7	2021	Mechanistically, we identified a novel lncRNA ITSN1-OT1, which was induced by RAMPtp during DSS stimulation.	ramptp	78-84	intersectin 1	Homo sapiens	46-51
33248053-7	2021	Mechanistically, we identified a novel lncRNA ITSN1-OT1, which was induced by RAMPtp during DSS stimulation.	Dextran Sulfate	92-95	intersectin 1	Homo sapiens	46-51
31940485-4	2020	Here we show that the endocytic scaffold protein intersectin 1 clears release sites by direct SH3 domain-mediated association with a non-canonical proline-rich segment of synaptobrevin assembled into the SNARE complex for neuroexocytosis.	Proline	147-154	intersectin 1	Homo sapiens	49-62
32535200-7	2020	We showed that the SH3-binding polyproline motif recognized by IRSp53 in SHIP2 is different from the regions targeted by other PRR binding partners i.e., CIN85, ITSN or even Mena a common interactor of both SHIP2 and IRSp53.	polyproline	31-42	intersectin 1	Homo sapiens	161-165
25783631-7	2015	In this study, we investigated the expression pattern and distribution of intersectin1-L in patients with refractory epilepsy, in a rat model of pilocarpine-induced epilepsy, and in a rat model of amygdala-kindled epilepsy by immunohistochemistry, immunofluorescence, and Western blotting.	Pilocarpine	145-156	intersectin 1	Homo sapiens	74-86
28600358-6	2017	Mechanistically, we uncover novel direct interactions between endogenous GPR124 and the Rho guanine nucleotide exchange factors Elmo/Dock and intersectin (ITSN).	Guanine Nucleotides	92-110	intersectin 1	Homo sapiens	142-153
28600358-6	2017	Mechanistically, we uncover novel direct interactions between endogenous GPR124 and the Rho guanine nucleotide exchange factors Elmo/Dock and intersectin (ITSN).	Guanine Nucleotides	92-110	intersectin 1	Homo sapiens	155-159
30540523-4	2019	We have identified the long isoform of intersectin-1 (ITSN-1), a guanine nucleotide exchange factor for Cdc42, as a novel Golgi component and an interaction partner of GCC88 responsible for mediating the actin-dependent dispersal of the Golgi ribbon.	Guanine Nucleotides	65-83	intersectin 1	Homo sapiens	39-52
30540523-4	2019	We have identified the long isoform of intersectin-1 (ITSN-1), a guanine nucleotide exchange factor for Cdc42, as a novel Golgi component and an interaction partner of GCC88 responsible for mediating the actin-dependent dispersal of the Golgi ribbon.	Guanine Nucleotides	65-83	intersectin 1	Homo sapiens	54-60
29773874-7	2018	Furthermore, we discover ITSN1 and ITSN2 as podocytic guanine nucleotide exchange factors for Cdc42.	Guanine Nucleotides	54-72	intersectin 1	Homo sapiens	25-30
24216759-7	2014	In addition, disruption of ITSN1 binding to Spry2 through point mutation of the Pro-rich ITSN1 binding site in Spry2 resulted in decreased Shp2-Spry2 interaction and enhanced Spry2 tyrosine phosphorylation.	Tyrosine	181-189	intersectin 1	Homo sapiens	27-32
24216759-7	2014	In addition, disruption of ITSN1 binding to Spry2 through point mutation of the Pro-rich ITSN1 binding site in Spry2 resulted in decreased Shp2-Spry2 interaction and enhanced Spry2 tyrosine phosphorylation.	Tyrosine	181-189	intersectin 1	Homo sapiens	89-94
22975684-7	2013	The Shb adaptor interacts simultaneously with the phosphorylated tyrosines of LMP2A and the SH3 domains of ITSN1 and mediates indirect interaction of ITSN1 to LMP2A.	Tyrosine	65-74	intersectin 1	Homo sapiens	107-112
23893408-9	2013	Our findings identify a novel GrB-EH(ITSN)-dependent pathogenic p38(MAPK)/Elk-1 signaling pathway involved in the poorly understood process of PL formation in severe PAH.	pl	143-145	intersectin 1	Homo sapiens	37-41
23274495-2	2013	ITSN-2L possesses a carboxy-terminal extension encoding a Dbl homology domain (DH), a pleckstrin homology domain (PH) and a C2 domain, suggesting that it could act as a guanine nucleotide exchange factor for Rho-like GTPases.	Guanine Nucleotides	169-187	intersectin 1	Homo sapiens	0-4
23284167-9	2013	Thus, ZCL278 is a small molecule that specifically targets Cdc42-ITSN interaction and inhibits Cdc42-mediated cellular processes, thus providing a powerful tool for research of Cdc42 subclass of Rho GTPases in human pathogenesis, such as those of cancer and neurological disorders.	ZCL278	6-12	intersectin 1	Homo sapiens	65-69
23936226-0	2013	Adaptor proteins intersectin 1 and 2 bind similar proline-rich ligands but are differentially recognized by SH2 domain-containing proteins.	Proline	50-57	intersectin 1	Homo sapiens	17-28
22975684-7	2013	The Shb adaptor interacts simultaneously with the phosphorylated tyrosines of LMP2A and the SH3 domains of ITSN1 and mediates indirect interaction of ITSN1 to LMP2A.	Tyrosine	65-74	intersectin 1	Homo sapiens	150-155