PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9830045-0	1998	Ceramide regulates the transcription of cyclooxygenase-2.	Ceramides	0-8	prostaglandin-endoperoxide synthase 2	Homo sapiens	40-56	
9830045-3	1998	We determined whether ceramide, a lipid second messenger, induced cyclooxygenase-2 (COX-2) in human mammary epithelial cells.	Ceramides	22-30	prostaglandin-endoperoxide synthase 2	Homo sapiens	66-82	
9830045-3	1998	We determined whether ceramide, a lipid second messenger, induced cyclooxygenase-2 (COX-2) in human mammary epithelial cells.	Ceramides	22-30	prostaglandin-endoperoxide synthase 2	Homo sapiens	84-89	
9830045-4	1998	Treatment of cells with neutral SMase or C2- or C6-ceramide enhanced prostaglandin E2 synthesis and increased levels of COX-2 protein and mRNA.	A(2)C	41-43	prostaglandin-endoperoxide synthase 2	Homo sapiens	120-125	
9830045-4	1998	Treatment of cells with neutral SMase or C2- or C6-ceramide enhanced prostaglandin E2 synthesis and increased levels of COX-2 protein and mRNA.	Ceramides	50-59	prostaglandin-endoperoxide synthase 2	Homo sapiens	120-125	
9830045-5	1998	Nuclear runoff assays revealed increased rates of COX-2 transcription after treatment with SMase and C2- and C6-ceramide.	Ceramides	112-120	prostaglandin-endoperoxide synthase 2	Homo sapiens	50-55	
9830045-6	1998	Transient transfections utilizing COX-2 promoter deletion constructs and COX-2 promoter constructs in which specific enhancer elements were mutagenized indicated that the effects of ceramide were mediated via a cAMP response element.	Ceramides	182-190	prostaglandin-endoperoxide synthase 2	Homo sapiens	34-39	
9830045-6	1998	Transient transfections utilizing COX-2 promoter deletion constructs and COX-2 promoter constructs in which specific enhancer elements were mutagenized indicated that the effects of ceramide were mediated via a cAMP response element.	Ceramides	182-190	prostaglandin-endoperoxide synthase 2	Homo sapiens	73-78	
9830045-6	1998	Transient transfections utilizing COX-2 promoter deletion constructs and COX-2 promoter constructs in which specific enhancer elements were mutagenized indicated that the effects of ceramide were mediated via a cAMP response element.	Cyclic AMP	211-215	prostaglandin-endoperoxide synthase 2	Homo sapiens	73-78	
9830045-7	1998	The induction of COX-2 by ceramide was inhibited by calphostin C, an inhibitor of protein kinase C. Induction of COX-2 promoter activity by SMase was blocked by overexpressing kinase-deficient Raf-1.	Ceramides	26-34	prostaglandin-endoperoxide synthase 2	Homo sapiens	17-22	
9830045-7	1998	The induction of COX-2 by ceramide was inhibited by calphostin C, an inhibitor of protein kinase C. Induction of COX-2 promoter activity by SMase was blocked by overexpressing kinase-deficient Raf-1.	Ceramides	26-34	prostaglandin-endoperoxide synthase 2	Homo sapiens	113-118	
9830045-7	1998	The induction of COX-2 by ceramide was inhibited by calphostin C, an inhibitor of protein kinase C. Induction of COX-2 promoter activity by SMase was blocked by overexpressing kinase-deficient Raf-1.	Ceramides	26-34	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	193-198	
9830045-8	1998	Triggering of the ceramide pathway also led to increases in extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38 mitogen-activated protein kinase (MAPK) activities; pharmacological inhibitors of MAPK kinase (MEK) and p38 MAPK blocked the induction of COX-2 by SMase.	Ceramides	18-26	mitogen-activated protein kinase 1	Homo sapiens	60-97	
9830045-8	1998	Triggering of the ceramide pathway also led to increases in extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38 mitogen-activated protein kinase (MAPK) activities; pharmacological inhibitors of MAPK kinase (MEK) and p38 MAPK blocked the induction of COX-2 by SMase.	Ceramides	18-26	mitogen-activated protein kinase 1	Homo sapiens	99-102	
9830045-8	1998	Triggering of the ceramide pathway also led to increases in extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38 mitogen-activated protein kinase (MAPK) activities; pharmacological inhibitors of MAPK kinase (MEK) and p38 MAPK blocked the induction of COX-2 by SMase.	Ceramides	18-26	mitogen-activated protein kinase 8	Homo sapiens	105-128	
9830045-8	1998	Triggering of the ceramide pathway also led to increases in extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38 mitogen-activated protein kinase (MAPK) activities; pharmacological inhibitors of MAPK kinase (MEK) and p38 MAPK blocked the induction of COX-2 by SMase.	Ceramides	18-26	mitogen-activated protein kinase 8	Homo sapiens	130-133	
9830045-8	1998	Triggering of the ceramide pathway also led to increases in extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38 mitogen-activated protein kinase (MAPK) activities; pharmacological inhibitors of MAPK kinase (MEK) and p38 MAPK blocked the induction of COX-2 by SMase.	Ceramides	18-26	mitogen-activated protein kinase 14	Homo sapiens	140-176	
9830045-8	1998	Triggering of the ceramide pathway also led to increases in extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38 mitogen-activated protein kinase (MAPK) activities; pharmacological inhibitors of MAPK kinase (MEK) and p38 MAPK blocked the induction of COX-2 by SMase.	Ceramides	18-26	mitogen-activated protein kinase 3	Homo sapiens	178-182	
9830045-8	1998	Triggering of the ceramide pathway also led to increases in extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38 mitogen-activated protein kinase (MAPK) activities; pharmacological inhibitors of MAPK kinase (MEK) and p38 MAPK blocked the induction of COX-2 by SMase.	Ceramides	18-26	mitogen-activated protein kinase 3	Homo sapiens	226-230	
9830045-8	1998	Triggering of the ceramide pathway also led to increases in extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38 mitogen-activated protein kinase (MAPK) activities; pharmacological inhibitors of MAPK kinase (MEK) and p38 MAPK blocked the induction of COX-2 by SMase.	Ceramides	18-26	mitogen-activated protein kinase kinase 7	Homo sapiens	239-242	
9830045-8	1998	Triggering of the ceramide pathway also led to increases in extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38 mitogen-activated protein kinase (MAPK) activities; pharmacological inhibitors of MAPK kinase (MEK) and p38 MAPK blocked the induction of COX-2 by SMase.	Ceramides	18-26	mitogen-activated protein kinase 1	Homo sapiens	140-143	
9830045-8	1998	Triggering of the ceramide pathway also led to increases in extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38 mitogen-activated protein kinase (MAPK) activities; pharmacological inhibitors of MAPK kinase (MEK) and p38 MAPK blocked the induction of COX-2 by SMase.	Ceramides	18-26	prostaglandin-endoperoxide synthase 2	Homo sapiens	282-287	
9830045-11	1998	A dominant negative for c-Jun inhibited the activation of COX-2 promoter activity by ceramide.	Ceramides	85-93	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	24-29	
9830045-11	1998	A dominant negative for c-Jun inhibited the activation of COX-2 promoter activity by ceramide.	Ceramides	85-93	prostaglandin-endoperoxide synthase 2	Homo sapiens	58-63	
9830045-12	1998	Thus, in response to ceramide, increased MAPK signaling activates c-Jun, which, in turn, induces COX-2 gene expression via the cAMP response element in the COX-2 promoter.	Ceramides	21-29	mitogen-activated protein kinase 3	Homo sapiens	41-45	
9830045-12	1998	Thus, in response to ceramide, increased MAPK signaling activates c-Jun, which, in turn, induces COX-2 gene expression via the cAMP response element in the COX-2 promoter.	Ceramides	21-29	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	66-71	
9830045-12	1998	Thus, in response to ceramide, increased MAPK signaling activates c-Jun, which, in turn, induces COX-2 gene expression via the cAMP response element in the COX-2 promoter.	Ceramides	21-29	prostaglandin-endoperoxide synthase 2	Homo sapiens	97-102	
9830045-12	1998	Thus, in response to ceramide, increased MAPK signaling activates c-Jun, which, in turn, induces COX-2 gene expression via the cAMP response element in the COX-2 promoter.	Ceramides	21-29	prostaglandin-endoperoxide synthase 2	Homo sapiens	156-161	
9830045-12	1998	Thus, in response to ceramide, increased MAPK signaling activates c-Jun, which, in turn, induces COX-2 gene expression via the cAMP response element in the COX-2 promoter.	Cyclic AMP	127-131	mitogen-activated protein kinase 3	Homo sapiens	41-45	
9830045-12	1998	Thus, in response to ceramide, increased MAPK signaling activates c-Jun, which, in turn, induces COX-2 gene expression via the cAMP response element in the COX-2 promoter.	Cyclic AMP	127-131	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	66-71	
9830045-12	1998	Thus, in response to ceramide, increased MAPK signaling activates c-Jun, which, in turn, induces COX-2 gene expression via the cAMP response element in the COX-2 promoter.	Cyclic AMP	127-131	prostaglandin-endoperoxide synthase 2	Homo sapiens	97-102	
9830045-12	1998	Thus, in response to ceramide, increased MAPK signaling activates c-Jun, which, in turn, induces COX-2 gene expression via the cAMP response element in the COX-2 promoter.	Cyclic AMP	127-131	prostaglandin-endoperoxide synthase 2	Homo sapiens	156-161