PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9786905-7 1998 We also demonstrated that JNK activation does not require ceramide generation since in MCF7 cells transfected with a dominant-negative derivative of FADD (FADD-DN), which are resistant to the cytotoxic action of TNF, TNF induced JNK activation in the absence of ceramide generation. Ceramides 262-270 mitogen-activated protein kinase 8 Homo sapiens 26-29 9786905-7 1998 We also demonstrated that JNK activation does not require ceramide generation since in MCF7 cells transfected with a dominant-negative derivative of FADD (FADD-DN), which are resistant to the cytotoxic action of TNF, TNF induced JNK activation in the absence of ceramide generation. Ceramides 262-270 Fas associated via death domain Homo sapiens 149-153 9786905-7 1998 We also demonstrated that JNK activation does not require ceramide generation since in MCF7 cells transfected with a dominant-negative derivative of FADD (FADD-DN), which are resistant to the cytotoxic action of TNF, TNF induced JNK activation in the absence of ceramide generation. Ceramides 262-270 Fas associated via death domain Homo sapiens 155-162 9786905-8 1998 Furthermore, our data indicate that exogenous permeable synthetic ceramide C-6 induced the killing of MCF7 cells transfected with MKK4 dominant-negative cDNA. ceramide c-6 66-78 mitogen-activated protein kinase kinase 4 Homo sapiens 130-134