PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9778049-3	1998	Herein we show that RA-induced LCL accumulation in the G0/G1 phases correlated with the loss of the catalytic activity of all three G1-associated CDKs (CDK2, CDK4 and CDK6) and with increased levels of underphosphorylated pRb and, in some LCLs, p130.	Tretinoin	20-22	cyclin dependent kinase 4	Homo sapiens	158-162	
9778049-6	1998	p27Kip-1 may also contribute to the inhibition of CDK4 kinase activity, as the amount of CDK4-associated p27Kip-1 was increased by 50% after RA exposure.	Tretinoin	141-143	cyclin dependent kinase 4	Homo sapiens	50-54	
9778049-6	1998	p27Kip-1 may also contribute to the inhibition of CDK4 kinase activity, as the amount of CDK4-associated p27Kip-1 was increased by 50% after RA exposure.	Tretinoin	141-143	cyclin dependent kinase 4	Homo sapiens	89-93	
9778049-9	1998	Overall, these results demonstrate that RA treatment of EBV-immortalized B lymphocytes is associated with multiple effects on G1 regulatory proteins, including p27Kip1 up-regulation, decreased levels of cyclins D2, D3 and A, and inhibition of CDK2, CDK4 and CDK6 activity, which ultimately result in reduced pRb phosphorylation and G0/G1 growth arrest.	Tretinoin	40-42	cyclin dependent kinase 4	Homo sapiens	249-253