PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9751485-7 1998 A23187- or thapsigargin-induced arachidonate release is prevented by a bromoenol lactone (BEL) inhibitor of a beta-cell phospholipase A2 (iPLA2), which does not require Ca2+ for catalytic activity and which is negatively modulated by and physically interacts with calmodulin by Ca2+-dependent mechanisms. Arachidonic Acid 32-44 phospholipase A2 group VI Homo sapiens 138-143 9751485-8 1998 Agents that cause Ca2+ loss from islet intracellular compartments thus induce arachidonate hydrolysis from phospholipids by a BEL-sensitive mechanism that does not require a rise in cytosolic [Ca2+], and a BEL-sensitive enzyme-like iPLA2 or a related membranous activity may participate in sensing Ca2+ compartment content. Arachidonic Acid 78-90 phospholipase A2 group VI Homo sapiens 232-237