PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9714324-1 1998 The effect of down-regulation of folylpoly-gamma-glutamate synthetase (FPGS) activity on intracellular reduced folate accumulation and cellular proliferation was examined, using an inducible antisense expression system in the human T-lymphoblastic leukemia cell line CCRF-CEM. Folic Acid 111-117 folylpolyglutamate synthase Homo sapiens 33-69 9714324-1 1998 The effect of down-regulation of folylpoly-gamma-glutamate synthetase (FPGS) activity on intracellular reduced folate accumulation and cellular proliferation was examined, using an inducible antisense expression system in the human T-lymphoblastic leukemia cell line CCRF-CEM. Folic Acid 111-117 folylpolyglutamate synthase Homo sapiens 71-75 9714324-2 1998 FPGS catalyzes the addition of gamma-glutamyl residues to natural folates and classical antifolates, which results in their enhanced cellular retention and increased cytotoxicity. Folic Acid 66-73 folylpolyglutamate synthase Homo sapiens 0-4 9714324-6 1998 This inducible expression system was used to demonstrate that lower FPGS activity can lead to substantially lower intracellular folate content, which coincides with suppression of thymidylate synthesis and inhibition of cellular proliferation. Folic Acid 128-134 folylpolyglutamate synthase Homo sapiens 68-72