PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9621513-5 1998 A mutation at codon 918, causing the substitution of threonine for methionine in the tyrosine kinase domain of the protein, was found in germline DNAs of all four patients with MEN2B and in two of the 22 patients with sporadic MTCs; codon 918 was mutated somatically in tumor DNAs from three other sporadic cases. Threonine 53-62 ret proto-oncogene Homo sapiens 177-182