PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9582014-0	1998	In B16 melanoma cells, the inhibition of melanogenesis by TPA results from PKC activation and diminution of microphthalmia binding to the M-box of the tyrosinase promoter.	Tetradecanoylphorbol Acetate	58-61	tyrosinase	Mus musculus	151-161	
9582014-4	1998	Further, the inhibition of melanogenesis by TPA results from a decrease of the tyrosinase promoter transcriptional activity and this effect is mimicked by over-expression of a constitutively active form of PKC alpha.	Tetradecanoylphorbol Acetate	44-47	tyrosinase	Mus musculus	79-89	
9582014-6	1998	Additional experiments were undertaken to elucidate the mechanism by which TPA inhibits the tyrosinase gene transcription.	Tetradecanoylphorbol Acetate	75-78	tyrosinase	Mus musculus	92-102	
9582014-7	1998	Deletions and mutation in the tyrosinase promoter showed that TPA acts on a M-box which is involved in tissue-specific expression and regulation by cAMP of the tyrosinase gene.	Tetradecanoylphorbol Acetate	62-65	tyrosinase	Mus musculus	30-40	
9582014-7	1998	Deletions and mutation in the tyrosinase promoter showed that TPA acts on a M-box which is involved in tissue-specific expression and regulation by cAMP of the tyrosinase gene.	Tetradecanoylphorbol Acetate	62-65	tyrosinase	Mus musculus	160-170	
9582014-9	1998	Since microphthalmia, strongly stimulates the transcriptional activity of the promoter we propose that TPA, through PKC activation, decreases microphthalmia binding to the M-box of the tyrosinase promoter, thereby leading to a reduced tyrosinase expression and melanogenesis inhibition.	Tetradecanoylphorbol Acetate	103-106	tyrosinase	Mus musculus	185-195	
9582014-9	1998	Since microphthalmia, strongly stimulates the transcriptional activity of the promoter we propose that TPA, through PKC activation, decreases microphthalmia binding to the M-box of the tyrosinase promoter, thereby leading to a reduced tyrosinase expression and melanogenesis inhibition.	Tetradecanoylphorbol Acetate	103-106	tyrosinase	Mus musculus	235-245