PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9578548-11 1998 The acyl-enzyme inhibitor hydroxyl is properly positioned for nucleophilic attack on the ester carbonyl and therefore relactonization; furthermore, the higher resolution structure of alpha-thrombin/GR133487 shows this hydroxyl to be effectively superimposable with the recently proposed deacylating water for peptide substrate hydrolysis [Wilmouth, R. C., et al. Esters 89-94 coagulation factor II, thrombin Homo sapiens 189-197