PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9492043-0 1998 p53 regulates insulin-like growth factor-I (IGF-I) receptor expression and IGF-I-induced tyrosine phosphorylation in an osteosarcoma cell line: interaction between p53 and Sp1. Tyrosine 89-97 tumor protein p53 Homo sapiens 0-3 9492043-5 1998 Similarly, wild-type p53 decreased IGF-I-induced tyrosine phosphorylation of IRS-1. Tyrosine 49-57 tumor protein p53 Homo sapiens 21-24 9492043-10 1998 In conclusion, p53 regulates IGF-IR expression, as reflected by a reduction in IGF-IR protein and a parallel reduction in IGF-I-induced tyrosine phosphorylation of the IGF-IR and IRS-1 in an osteosarcoma cell line. Tyrosine 136-144 tumor protein p53 Homo sapiens 15-18