PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9488042-1	1998	In a previous study, we demonstrated that bufalin caused apoptosis in human leukemia U937 cells by the anomalous activation of mitogen-activated protein kinase (MAPK) via a signaling pathway that included Ras, Raf-1 and MAPK kinase-1.	bufalin	42-49	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	210-215	
9488042-2	1998	We report here the effect of bufalin on c-Jun N-terminal protein kinase (JNK), a member of the MAPK family, and on the signaling pathway downstream of MAPKs in U937 cells.	bufalin	29-36	mitogen-activated protein kinase 8	Homo sapiens	40-71	
9488042-2	1998	We report here the effect of bufalin on c-Jun N-terminal protein kinase (JNK), a member of the MAPK family, and on the signaling pathway downstream of MAPKs in U937 cells.	bufalin	29-36	mitogen-activated protein kinase 8	Homo sapiens	73-76	
9488042-3	1998	When U937 cells were treated with 10(-8) M bufalin, the activity of JNK1 was markedly elevated 3 h after the start of treatment and remained so for 9 h. This activation of JNK and the induction of apoptosis by bufalin were suppressed by expression of antisense mRNA for MAPK kinase-1.	bufalin	43-50	mitogen-activated protein kinase 8	Homo sapiens	68-72	
9488042-3	1998	When U937 cells were treated with 10(-8) M bufalin, the activity of JNK1 was markedly elevated 3 h after the start of treatment and remained so for 9 h. This activation of JNK and the induction of apoptosis by bufalin were suppressed by expression of antisense mRNA for MAPK kinase-1.	bufalin	43-50	mitogen-activated protein kinase 8	Homo sapiens	68-71	
9488042-3	1998	When U937 cells were treated with 10(-8) M bufalin, the activity of JNK1 was markedly elevated 3 h after the start of treatment and remained so for 9 h. This activation of JNK and the induction of apoptosis by bufalin were suppressed by expression of antisense mRNA for MAPK kinase-1.	bufalin	210-217	mitogen-activated protein kinase 8	Homo sapiens	68-72	
9488042-3	1998	When U937 cells were treated with 10(-8) M bufalin, the activity of JNK1 was markedly elevated 3 h after the start of treatment and remained so for 9 h. This activation of JNK and the induction of apoptosis by bufalin were suppressed by expression of antisense mRNA for MAPK kinase-1.	bufalin	210-217	mitogen-activated protein kinase 8	Homo sapiens	68-71	
9488042-4	1998	c-Jun was translocated from the cytoplasm to the nucleus after treatment of U937 cells with bufalin.	bufalin	92-99	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	0-5	
9488042-6	1998	Both curcumin (1,7-bis[4-hydroxy-3-methoxy-phenyl]-1,6-heptadiene-3,5-dione), an inhibitor of the biosynthesis of AP-1, and the expression of dominant negative c-Jun inhibited the activation of AP-1 and the induction of apoptosis by bufalin.	Curcumin	5-13	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	160-165	
9488042-8	1998	These results suggest that the activation of AP-1 via a MAPK cascade that includes JNK is required for the induction of apoptosis by bufalin in U937 cells.	bufalin	133-140	mitogen-activated protein kinase 8	Homo sapiens	83-86