PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9443857-0	1998	Ethosuximide is primarily metabolized by CYP3A when incubated with isolated rat liver microsomes.	Ethosuximide	0-12	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	41-46	
9443857-1	1998	The cytochrome P450 (CYP) subfamily responsible for ethosuximide metabolism was investigated by HPLC assay of ethosuximide incubations with isolated rat liver microsomes from control rats and from rats treated with inducing agents to enrich hepatic microsomes in selected CYP isoforms.	Ethosuximide	52-64	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	4-19	
9443857-1	1998	The cytochrome P450 (CYP) subfamily responsible for ethosuximide metabolism was investigated by HPLC assay of ethosuximide incubations with isolated rat liver microsomes from control rats and from rats treated with inducing agents to enrich hepatic microsomes in selected CYP isoforms.	Ethosuximide	52-64	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	21-24	
9443857-1	1998	The cytochrome P450 (CYP) subfamily responsible for ethosuximide metabolism was investigated by HPLC assay of ethosuximide incubations with isolated rat liver microsomes from control rats and from rats treated with inducing agents to enrich hepatic microsomes in selected CYP isoforms.	Ethosuximide	52-64	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	272-275	
9443857-1	1998	The cytochrome P450 (CYP) subfamily responsible for ethosuximide metabolism was investigated by HPLC assay of ethosuximide incubations with isolated rat liver microsomes from control rats and from rats treated with inducing agents to enrich hepatic microsomes in selected CYP isoforms.	Ethosuximide	110-122	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	4-19	
9443857-1	1998	The cytochrome P450 (CYP) subfamily responsible for ethosuximide metabolism was investigated by HPLC assay of ethosuximide incubations with isolated rat liver microsomes from control rats and from rats treated with inducing agents to enrich hepatic microsomes in selected CYP isoforms.	Ethosuximide	110-122	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	21-24	
9443857-6	1998	Sixty-minute incubations with all microsome groups exhibited significantly (p<0.05) higher metabolite formation rates (nmol/nmol CYP/min) for CTZ (11.8x control) and PB (9.6x control) microsomes vs. all other groups.	Clotrimazole	145-148	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	132-135	
9443857-7	1998	Antibody inhibition experiments demonstrated ethosuximide metabolite levels for PB microsomes were not affected by CYP2B1 antibodies, whereas CYP3A2 antibodies reduced metabolite levels for both PB and CTZ microsomes by over 80%.	Phenobarbital	195-197	cytochrome P450, family 3, subfamily a, polypeptide 2	Rattus norvegicus	142-148	
9443857-7	1998	Antibody inhibition experiments demonstrated ethosuximide metabolite levels for PB microsomes were not affected by CYP2B1 antibodies, whereas CYP3A2 antibodies reduced metabolite levels for both PB and CTZ microsomes by over 80%.	Clotrimazole	202-205	cytochrome P450, family 3, subfamily a, polypeptide 2	Rattus norvegicus	142-148	
9443857-8	1998	These results indicate CYP3A is primarily responsible for ethosuximide metabolism in rats.	Ethosuximide	58-70	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	23-28