PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9430725-0	1998	Molecular mechanisms of c-Jun N-terminal kinase-mediated apoptosis induced by anticarcinogenic isothiocyanates.	Isothiocyanates	95-110	mitogen-activated protein kinase 8	Homo sapiens	24-47	
9430725-2	1998	Here, we report that phenylmethyl isocyacyanate (PMITC) and phenylethyl isothiocyanate (PEITC) induced sustained c-Jun N-terminal kinase (JNK) activation in a dose-dependent manner.	phenylmethyl isocyacyanate	21-47	mitogen-activated protein kinase 8	Homo sapiens	113-136	
9430725-2	1998	Here, we report that phenylmethyl isocyacyanate (PMITC) and phenylethyl isothiocyanate (PEITC) induced sustained c-Jun N-terminal kinase (JNK) activation in a dose-dependent manner.	phenylmethyl isocyacyanate	21-47	mitogen-activated protein kinase 8	Homo sapiens	138-141	
9430725-2	1998	Here, we report that phenylmethyl isocyacyanate (PMITC) and phenylethyl isothiocyanate (PEITC) induced sustained c-Jun N-terminal kinase (JNK) activation in a dose-dependent manner.	pmitc	49-54	mitogen-activated protein kinase 8	Homo sapiens	113-136	
9430725-2	1998	Here, we report that phenylmethyl isocyacyanate (PMITC) and phenylethyl isothiocyanate (PEITC) induced sustained c-Jun N-terminal kinase (JNK) activation in a dose-dependent manner.	pmitc	49-54	mitogen-activated protein kinase 8	Homo sapiens	138-141	
9430725-2	1998	Here, we report that phenylmethyl isocyacyanate (PMITC) and phenylethyl isothiocyanate (PEITC) induced sustained c-Jun N-terminal kinase (JNK) activation in a dose-dependent manner.	phenethyl isothiocyanate	60-86	mitogen-activated protein kinase 8	Homo sapiens	113-136	
9430725-2	1998	Here, we report that phenylmethyl isocyacyanate (PMITC) and phenylethyl isothiocyanate (PEITC) induced sustained c-Jun N-terminal kinase (JNK) activation in a dose-dependent manner.	phenethyl isothiocyanate	60-86	mitogen-activated protein kinase 8	Homo sapiens	138-141	
9430725-2	1998	Here, we report that phenylmethyl isocyacyanate (PMITC) and phenylethyl isothiocyanate (PEITC) induced sustained c-Jun N-terminal kinase (JNK) activation in a dose-dependent manner.	phenethyl isothiocyanate	88-93	mitogen-activated protein kinase 8	Homo sapiens	113-136	
9430725-2	1998	Here, we report that phenylmethyl isocyacyanate (PMITC) and phenylethyl isothiocyanate (PEITC) induced sustained c-Jun N-terminal kinase (JNK) activation in a dose-dependent manner.	phenethyl isothiocyanate	88-93	mitogen-activated protein kinase 8	Homo sapiens	138-141	
9430725-3	1998	The sustained JNK activation caused by isothiocyanates was associated with apoptosis induction in various cell types.	Isothiocyanates	39-54	mitogen-activated protein kinase 8	Homo sapiens	14-17	
9430725-4	1998	An inhibitor of the caspase/interleukin-1 beta-converting enzyme blocked isothiocyanate-induced apoptosis without inhibiting the JNK activation, which suggests that JNK activation by isothiocyanates is an event that is independent or upstream of the activation of caspase/interleukin-1 beta-converting enzyme proteases.	isothiocyanic acid	73-87	mitogen-activated protein kinase 8	Homo sapiens	165-168	
9430725-4	1998	An inhibitor of the caspase/interleukin-1 beta-converting enzyme blocked isothiocyanate-induced apoptosis without inhibiting the JNK activation, which suggests that JNK activation by isothiocyanates is an event that is independent or upstream of the activation of caspase/interleukin-1 beta-converting enzyme proteases.	Isothiocyanates	183-198	mitogen-activated protein kinase 8	Homo sapiens	165-168	
9430725-5	1998	PEITC-induced apoptosis was suppressed by interfering with the JNK pathway with a dominant-negative mutant of JNK1 or MEKK1 (JNK1(APF) and MEKK1 (KR), respectively), implying that the JNK pathway is required for apoptotic signaling.	phenethyl isothiocyanate	0-5	mitogen-activated protein kinase 8	Homo sapiens	63-66	
9430725-5	1998	PEITC-induced apoptosis was suppressed by interfering with the JNK pathway with a dominant-negative mutant of JNK1 or MEKK1 (JNK1(APF) and MEKK1 (KR), respectively), implying that the JNK pathway is required for apoptotic signaling.	phenethyl isothiocyanate	0-5	mitogen-activated protein kinase 8	Homo sapiens	110-114	
9430725-5	1998	PEITC-induced apoptosis was suppressed by interfering with the JNK pathway with a dominant-negative mutant of JNK1 or MEKK1 (JNK1(APF) and MEKK1 (KR), respectively), implying that the JNK pathway is required for apoptotic signaling.	phenethyl isothiocyanate	0-5	mitogen-activated protein kinase kinase kinase 1	Homo sapiens	118-123	
9430725-5	1998	PEITC-induced apoptosis was suppressed by interfering with the JNK pathway with a dominant-negative mutant of JNK1 or MEKK1 (JNK1(APF) and MEKK1 (KR), respectively), implying that the JNK pathway is required for apoptotic signaling.	phenethyl isothiocyanate	0-5	mitogen-activated protein kinase 8	Homo sapiens	125-134	
9430725-5	1998	PEITC-induced apoptosis was suppressed by interfering with the JNK pathway with a dominant-negative mutant of JNK1 or MEKK1 (JNK1(APF) and MEKK1 (KR), respectively), implying that the JNK pathway is required for apoptotic signaling.	phenethyl isothiocyanate	0-5	mitogen-activated protein kinase kinase kinase 1	Homo sapiens	139-144	
9430725-5	1998	PEITC-induced apoptosis was suppressed by interfering with the JNK pathway with a dominant-negative mutant of JNK1 or MEKK1 (JNK1(APF) and MEKK1 (KR), respectively), implying that the JNK pathway is required for apoptotic signaling.	phenethyl isothiocyanate	0-5	mitogen-activated protein kinase 8	Homo sapiens	110-113	
9430725-6	1998	Isothiocyanate-induced JNK activation was blocked by the antioxidants 2-mercaptoethanol and N-acetyl-L-cysteine, suggesting that the death signaling was triggered by oxidative stress.	isothiocyanic acid	0-14	mitogen-activated protein kinase 8	Homo sapiens	23-26	
9430725-6	1998	Isothiocyanate-induced JNK activation was blocked by the antioxidants 2-mercaptoethanol and N-acetyl-L-cysteine, suggesting that the death signaling was triggered by oxidative stress.	Mercaptoethanol	70-87	mitogen-activated protein kinase 8	Homo sapiens	23-26	
9430725-6	1998	Isothiocyanate-induced JNK activation was blocked by the antioxidants 2-mercaptoethanol and N-acetyl-L-cysteine, suggesting that the death signaling was triggered by oxidative stress.	Acetylcysteine	92-111	mitogen-activated protein kinase 8	Homo sapiens	23-26