PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9398733-0 1997 Dose-dependent effects of recombinant human interleukin-6 on glucose regulation. Glucose 61-68 interleukin 6 Homo sapiens 44-57 9398733-2 1997 To examine the effects of interleukin 6 (IL-6), the main circulating cytokine, on glucose metabolism in man, we performed dose-response studies of recombinant human IL-6 in normal volunteers. Glucose 82-89 interleukin 6 Homo sapiens 41-45 9398733-8 1997 By 60 min after the 3 higher IL-6 doses, however, the decline in fasting blood glucose was arrested, and glucose levels increased in a dose-dependent fashion. Glucose 79-86 interleukin 6 Homo sapiens 29-33 9398733-8 1997 By 60 min after the 3 higher IL-6 doses, however, the decline in fasting blood glucose was arrested, and glucose levels increased in a dose-dependent fashion. Glucose 105-112 interleukin 6 Homo sapiens 29-33 9398733-11 1997 In conclusion, sc IL-6 administration induced dose-dependent increases in fasting blood glucose, probably by stimulating glucagon release and other counteregulatory hormones and/or by inducing peripheral resistance to insulin action. Glucose 88-95 interleukin 6 Homo sapiens 18-22