PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9362518-0	1997	Fas induces cytoplasmic apoptotic responses and activation of the MKK7-JNK/SAPK and MKK6-p38 pathways independent of CPP32-like proteases.	ammonium ferrous sulfate	0-3	mitogen-activated protein kinase kinase 7	Homo sapiens	66-70	
9362518-0	1997	Fas induces cytoplasmic apoptotic responses and activation of the MKK7-JNK/SAPK and MKK6-p38 pathways independent of CPP32-like proteases.	ammonium ferrous sulfate	0-3	mitogen-activated protein kinase 8	Homo sapiens	71-74	
9362518-0	1997	Fas induces cytoplasmic apoptotic responses and activation of the MKK7-JNK/SAPK and MKK6-p38 pathways independent of CPP32-like proteases.	ammonium ferrous sulfate	0-3	mitogen-activated protein kinase kinase 6	Homo sapiens	84-88	
9362518-0	1997	Fas induces cytoplasmic apoptotic responses and activation of the MKK7-JNK/SAPK and MKK6-p38 pathways independent of CPP32-like proteases.	ammonium ferrous sulfate	0-3	mitogen-activated protein kinase 14	Homo sapiens	89-92	
9362518-0	1997	Fas induces cytoplasmic apoptotic responses and activation of the MKK7-JNK/SAPK and MKK6-p38 pathways independent of CPP32-like proteases.	ammonium ferrous sulfate	0-3	caspase 3	Homo sapiens	117-122	
9362518-3	1997	It was recently reported that two subfamily members of the mitogen-activated protein kinase superfamily, JNK/SAPK and p38, are activated during Fas-induced apoptosis.	ammonium ferrous sulfate	144-147	mitogen-activated protein kinase 8	Homo sapiens	105-108	
9362518-3	1997	It was recently reported that two subfamily members of the mitogen-activated protein kinase superfamily, JNK/SAPK and p38, are activated during Fas-induced apoptosis.	ammonium ferrous sulfate	144-147	mitogen-activated protein kinase 14	Homo sapiens	118-121	
9362518-4	1997	Here, we have shown that MKK7, but not SEK1/ MKK4, is activated by Fas as an activator for JNK/ SAPK and that MKK6 is a major activator for p38 in Fas signaling.	ammonium ferrous sulfate	67-70	mitogen-activated protein kinase kinase 7	Homo sapiens	25-29	
9362518-4	1997	Here, we have shown that MKK7, but not SEK1/ MKK4, is activated by Fas as an activator for JNK/ SAPK and that MKK6 is a major activator for p38 in Fas signaling.	ammonium ferrous sulfate	67-70	mitogen-activated protein kinase 8	Homo sapiens	91-94	
9362518-4	1997	Here, we have shown that MKK7, but not SEK1/ MKK4, is activated by Fas as an activator for JNK/ SAPK and that MKK6 is a major activator for p38 in Fas signaling.	ammonium ferrous sulfate	147-150	mitogen-activated protein kinase kinase 7	Homo sapiens	25-29	
9362518-4	1997	Here, we have shown that MKK7, but not SEK1/ MKK4, is activated by Fas as an activator for JNK/ SAPK and that MKK6 is a major activator for p38 in Fas signaling.	ammonium ferrous sulfate	147-150	mitogen-activated protein kinase kinase 6	Homo sapiens	110-114	
9362518-4	1997	Here, we have shown that MKK7, but not SEK1/ MKK4, is activated by Fas as an activator for JNK/ SAPK and that MKK6 is a major activator for p38 in Fas signaling.	ammonium ferrous sulfate	147-150	mitogen-activated protein kinase 14	Homo sapiens	140-143	
9362518-5	1997	Then, to dissect various cellular responses induced by Fas, we used several peptide inhibitors for ICE family proteases in Fas-treated Jurkat cells and KB cells.	ammonium ferrous sulfate	55-58	caspase 1	Homo sapiens	99-102	
9362518-6	1997	While Z-VAD-FK which inhibited almost all the Fas-induced cellular responses blocked the activation of JNK/SAPK and p38, Ac-DEVD-CHO and Z-DEVD-FK, specific inhibitors for CPP32-like proteases, which inhibited the Fas-induced chromatin condensation and DNA fragmentation did not block the activation of JNK/SAPK and p38.	z-vad-fk	6-14	mitogen-activated protein kinase 8	Homo sapiens	103-106	
9362518-6	1997	While Z-VAD-FK which inhibited almost all the Fas-induced cellular responses blocked the activation of JNK/SAPK and p38, Ac-DEVD-CHO and Z-DEVD-FK, specific inhibitors for CPP32-like proteases, which inhibited the Fas-induced chromatin condensation and DNA fragmentation did not block the activation of JNK/SAPK and p38.	z-vad-fk	6-14	mitogen-activated protein kinase 14	Homo sapiens	116-119	
9362518-6	1997	While Z-VAD-FK which inhibited almost all the Fas-induced cellular responses blocked the activation of JNK/SAPK and p38, Ac-DEVD-CHO and Z-DEVD-FK, specific inhibitors for CPP32-like proteases, which inhibited the Fas-induced chromatin condensation and DNA fragmentation did not block the activation of JNK/SAPK and p38.	z-vad-fk	6-14	caspase 3	Homo sapiens	172-177	
9362518-6	1997	While Z-VAD-FK which inhibited almost all the Fas-induced cellular responses blocked the activation of JNK/SAPK and p38, Ac-DEVD-CHO and Z-DEVD-FK, specific inhibitors for CPP32-like proteases, which inhibited the Fas-induced chromatin condensation and DNA fragmentation did not block the activation of JNK/SAPK and p38.	z-vad-fk	6-14	mitogen-activated protein kinase 8	Homo sapiens	303-306	
9362518-6	1997	While Z-VAD-FK which inhibited almost all the Fas-induced cellular responses blocked the activation of JNK/SAPK and p38, Ac-DEVD-CHO and Z-DEVD-FK, specific inhibitors for CPP32-like proteases, which inhibited the Fas-induced chromatin condensation and DNA fragmentation did not block the activation of JNK/SAPK and p38.	z-vad-fk	6-14	mitogen-activated protein kinase 14	Homo sapiens	316-319	
9362518-6	1997	While Z-VAD-FK which inhibited almost all the Fas-induced cellular responses blocked the activation of JNK/SAPK and p38, Ac-DEVD-CHO and Z-DEVD-FK, specific inhibitors for CPP32-like proteases, which inhibited the Fas-induced chromatin condensation and DNA fragmentation did not block the activation of JNK/SAPK and p38.	ammonium ferrous sulfate	46-49	mitogen-activated protein kinase 8	Homo sapiens	103-106	
9362518-6	1997	While Z-VAD-FK which inhibited almost all the Fas-induced cellular responses blocked the activation of JNK/SAPK and p38, Ac-DEVD-CHO and Z-DEVD-FK, specific inhibitors for CPP32-like proteases, which inhibited the Fas-induced chromatin condensation and DNA fragmentation did not block the activation of JNK/SAPK and p38.	ammonium ferrous sulfate	46-49	mitogen-activated protein kinase 14	Homo sapiens	116-119	
9362518-6	1997	While Z-VAD-FK which inhibited almost all the Fas-induced cellular responses blocked the activation of JNK/SAPK and p38, Ac-DEVD-CHO and Z-DEVD-FK, specific inhibitors for CPP32-like proteases, which inhibited the Fas-induced chromatin condensation and DNA fragmentation did not block the activation of JNK/SAPK and p38.	ammonium ferrous sulfate	46-49	caspase 3	Homo sapiens	172-177	
9362518-6	1997	While Z-VAD-FK which inhibited almost all the Fas-induced cellular responses blocked the activation of JNK/SAPK and p38, Ac-DEVD-CHO and Z-DEVD-FK, specific inhibitors for CPP32-like proteases, which inhibited the Fas-induced chromatin condensation and DNA fragmentation did not block the activation of JNK/SAPK and p38.	ammonium ferrous sulfate	46-49	mitogen-activated protein kinase 8	Homo sapiens	303-306	
9362518-6	1997	While Z-VAD-FK which inhibited almost all the Fas-induced cellular responses blocked the activation of JNK/SAPK and p38, Ac-DEVD-CHO and Z-DEVD-FK, specific inhibitors for CPP32-like proteases, which inhibited the Fas-induced chromatin condensation and DNA fragmentation did not block the activation of JNK/SAPK and p38.	ammonium ferrous sulfate	46-49	mitogen-activated protein kinase 14	Homo sapiens	316-319	
9362518-6	1997	While Z-VAD-FK which inhibited almost all the Fas-induced cellular responses blocked the activation of JNK/SAPK and p38, Ac-DEVD-CHO and Z-DEVD-FK, specific inhibitors for CPP32-like proteases, which inhibited the Fas-induced chromatin condensation and DNA fragmentation did not block the activation of JNK/SAPK and p38.	acetyl-aspartyl-glutamyl-valyl-aspartal	121-132	caspase 3	Homo sapiens	172-177	
9362518-6	1997	While Z-VAD-FK which inhibited almost all the Fas-induced cellular responses blocked the activation of JNK/SAPK and p38, Ac-DEVD-CHO and Z-DEVD-FK, specific inhibitors for CPP32-like proteases, which inhibited the Fas-induced chromatin condensation and DNA fragmentation did not block the activation of JNK/SAPK and p38.	acetyl-aspartyl-glutamyl-valyl-aspartal	121-132	mitogen-activated protein kinase 8	Homo sapiens	303-306	
9362518-6	1997	While Z-VAD-FK which inhibited almost all the Fas-induced cellular responses blocked the activation of JNK/SAPK and p38, Ac-DEVD-CHO and Z-DEVD-FK, specific inhibitors for CPP32-like proteases, which inhibited the Fas-induced chromatin condensation and DNA fragmentation did not block the activation of JNK/SAPK and p38.	acetyl-aspartyl-glutamyl-valyl-aspartal	121-132	mitogen-activated protein kinase 14	Homo sapiens	316-319	
9362518-6	1997	While Z-VAD-FK which inhibited almost all the Fas-induced cellular responses blocked the activation of JNK/SAPK and p38, Ac-DEVD-CHO and Z-DEVD-FK, specific inhibitors for CPP32-like proteases, which inhibited the Fas-induced chromatin condensation and DNA fragmentation did not block the activation of JNK/SAPK and p38.	z-devd-fk	137-146	caspase 3	Homo sapiens	172-177	
9362518-6	1997	While Z-VAD-FK which inhibited almost all the Fas-induced cellular responses blocked the activation of JNK/SAPK and p38, Ac-DEVD-CHO and Z-DEVD-FK, specific inhibitors for CPP32-like proteases, which inhibited the Fas-induced chromatin condensation and DNA fragmentation did not block the activation of JNK/SAPK and p38.	ammonium ferrous sulfate	214-217	mitogen-activated protein kinase 8	Homo sapiens	103-106	
9362518-6	1997	While Z-VAD-FK which inhibited almost all the Fas-induced cellular responses blocked the activation of JNK/SAPK and p38, Ac-DEVD-CHO and Z-DEVD-FK, specific inhibitors for CPP32-like proteases, which inhibited the Fas-induced chromatin condensation and DNA fragmentation did not block the activation of JNK/SAPK and p38.	ammonium ferrous sulfate	214-217	caspase 3	Homo sapiens	172-177	
9362518-8	1997	These results suggest that the Fas-induced activation of the JNK/SAPK and p38 signaling pathways does not require CPP32-like proteases and that CPP32-like proteases, although essential for apoptotic nuclear events (such as chromatin condensation and DNA fragmentation), are not required for other apoptotic events in the cytoplasm or the cell death itself.	ammonium ferrous sulfate	31-34	mitogen-activated protein kinase 8	Homo sapiens	61-64	
9362518-8	1997	These results suggest that the Fas-induced activation of the JNK/SAPK and p38 signaling pathways does not require CPP32-like proteases and that CPP32-like proteases, although essential for apoptotic nuclear events (such as chromatin condensation and DNA fragmentation), are not required for other apoptotic events in the cytoplasm or the cell death itself.	ammonium ferrous sulfate	31-34	mitogen-activated protein kinase 14	Homo sapiens	74-77