PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9321399-0 1997 Activation of CD95 (APO-1/Fas) signaling by ceramide mediates cancer therapy-induced apoptosis. Ceramides 44-52 Fas cell surface death receptor Homo sapiens 14-18 9321399-0 1997 Activation of CD95 (APO-1/Fas) signaling by ceramide mediates cancer therapy-induced apoptosis. Ceramides 44-52 Fas cell surface death receptor Homo sapiens 20-25 9321399-1 1997 We report here that anticancer drugs such as doxorubicin lead to induction of the CD95 (APO-1/Fas) system of apoptosis and the cellular stress pathway which includes JNK/SAPKs. Doxorubicin 45-56 Fas cell surface death receptor Homo sapiens 82-86 9321399-1 1997 We report here that anticancer drugs such as doxorubicin lead to induction of the CD95 (APO-1/Fas) system of apoptosis and the cellular stress pathway which includes JNK/SAPKs. Doxorubicin 45-56 Fas cell surface death receptor Homo sapiens 88-93 9321399-1 1997 We report here that anticancer drugs such as doxorubicin lead to induction of the CD95 (APO-1/Fas) system of apoptosis and the cellular stress pathway which includes JNK/SAPKs. Doxorubicin 45-56 mitogen-activated protein kinase 8 Homo sapiens 166-169 9321399-2 1997 Ceramide, which accumulates in response to different types of cellular stress such as chemo- and radiotherapy, strongly induced expression of CD95-L, cleavage of caspases and apoptosis. Ceramides 0-8 Fas ligand Homo sapiens 142-148 9321399-3 1997 Antisense CD95-L as well as dominant-negative FADD inhibited ceramide- and cellular stress-induced apoptosis. Ceramides 61-69 Fas ligand Homo sapiens 10-16 9321399-3 1997 Antisense CD95-L as well as dominant-negative FADD inhibited ceramide- and cellular stress-induced apoptosis. Ceramides 61-69 Fas associated via death domain Homo sapiens 46-50 9321399-5 1997 In contrast, JNK/SAPK activity was still inducible by doxorubicin in the NPA cells, suggesting that activation of JNK/SAPKs alone is not sufficient for induction of the CD95 system and apoptosis. Doxorubicin 54-65 mitogen-activated protein kinase 8 Homo sapiens 13-21 9321399-5 1997 In contrast, JNK/SAPK activity was still inducible by doxorubicin in the NPA cells, suggesting that activation of JNK/SAPKs alone is not sufficient for induction of the CD95 system and apoptosis. Doxorubicin 54-65 mitogen-activated protein kinase 8 Homo sapiens 13-16 9321399-6 1997 CD95-L expression and apoptosis in NPA fibroblasts were restorable by exogenously added ceramide. Ceramides 88-96 Fas cell surface death receptor Homo sapiens 0-4 9321399-8 1997 These data demonstrate that ceramide links cellular stress responses induced by gamma-irradiation or anticancer drugs to the CD95 pathway of apoptosis. Ceramides 28-36 Fas cell surface death receptor Homo sapiens 125-129