PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9316423-3	1997	Administration of alpha-difluoromethylornithine (DFMO), a specific inhibitor of polyamine synthesis, for 4 or 6 days not only almost completely depleted total (whole) cellular and nuclear polyamines but also significantly decreased expression of the protooncogenes c-myc and c-jun in IEC-6 cells.	Eflornithine	18-47	MYC proto-oncogene, bHLH transcription factor	Rattus norvegicus	265-270	
9316423-3	1997	Administration of alpha-difluoromethylornithine (DFMO), a specific inhibitor of polyamine synthesis, for 4 or 6 days not only almost completely depleted total (whole) cellular and nuclear polyamines but also significantly decreased expression of the protooncogenes c-myc and c-jun in IEC-6 cells.	Eflornithine	49-53	MYC proto-oncogene, bHLH transcription factor	Rattus norvegicus	265-270	
9316423-4	1997	Using nuclear run-on transcription assay, we demonstrated that the basal rate of transcription of c-myc was decreased by 55% at 4 days and by 60% at 6 days in the DFMO-treated cells.	Eflornithine	163-167	MYC proto-oncogene, bHLH transcription factor	Rattus norvegicus	98-103	
9316423-8	1997	Furthermore, direct administration of spermidine to isolated nuclei from polyamine-deficient (caused by DFMO) cells resulted in a 2- to 2.5-fold increase in c-myc and c-jun transcription.	Eflornithine	104-108	MYC proto-oncogene, bHLH transcription factor	Rattus norvegicus	157-162