PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9266970-0	1997	Dexamethasone induces apoptosis of multiple myeloma cells in a JNK/SAP kinase independent mechanism.	Dexamethasone	0-13	mitogen-activated protein kinase 8	Homo sapiens	63-66	
9266970-0	1997	Dexamethasone induces apoptosis of multiple myeloma cells in a JNK/SAP kinase independent mechanism.	Dexamethasone	0-13	amyloid P component, serum	Homo sapiens	67-70	
9266970-5	1997	Moreover, Dex-induced apoptosis is associated with a significant decrease in the activities of mitogen activated protein kinase (MAPK) and p70S6K, whereas IR-treatment does not alter the activity of these kinases.	Dexamethasone	10-13	ribosomal protein S6 kinase B1	Homo sapiens	139-145	
9266970-7	1997	Finally, interleukin-6 (IL-6) inhibits Dex-induced apoptosis, downregulation of MAP and p70S6K growth kinases and PARP cleavage; in contrast, IL-6 does not inhibit IR-induced apoptosis, activation of SAPK/JNK, and PARP cleavage.	Dexamethasone	39-42	interleukin 6	Homo sapiens	9-22	
9266970-7	1997	Finally, interleukin-6 (IL-6) inhibits Dex-induced apoptosis, downregulation of MAP and p70S6K growth kinases and PARP cleavage; in contrast, IL-6 does not inhibit IR-induced apoptosis, activation of SAPK/JNK, and PARP cleavage.	Dexamethasone	39-42	interleukin 6	Homo sapiens	24-28	
9266970-8	1997	Taken together, our findings suggest that SAPK/JNK activation is not required for apoptosis in MM cells, and that there are at least two distinct apoptotic signaling pathways: (i) SAPK/JNK-associated, which is induced by IR and unaffected by IL-6; and (ii) SAPK/JNK-independent, which is induced by Dex, associated with downregulation of MAPK and p70S6K and inhibited by IL-6.	Dexamethasone	299-302	mitogen-activated protein kinase 8	Homo sapiens	185-188	
9266970-8	1997	Taken together, our findings suggest that SAPK/JNK activation is not required for apoptosis in MM cells, and that there are at least two distinct apoptotic signaling pathways: (i) SAPK/JNK-associated, which is induced by IR and unaffected by IL-6; and (ii) SAPK/JNK-independent, which is induced by Dex, associated with downregulation of MAPK and p70S6K and inhibited by IL-6.	Dexamethasone	299-302	mitogen-activated protein kinase 8	Homo sapiens	185-188