PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9162025-0	1997	The Jun kinase/stress-activated protein kinase pathway functions to regulate DNA repair and inhibition of the pathway sensitizes tumor cells to cisplatin.	Cisplatin	144-153	mitogen-activated protein kinase 9	Homo sapiens	4-14	
9162025-1	1997	We have studied the role of Jun/stress-activated protein kinase (JNK/SAPK) pathway in DNA repair and cisplatin resistance in T98G glioblastoma cells.	Cisplatin	101-110	mitogen-activated protein kinase 8	Homo sapiens	65-73	
9162025-2	1997	JUN/SAPK is activated by DNA damage and phosphorylates serines 63 and 73 in the N-terminal domain of c-Jun, which is known to increase its transactivation properties.	Serine	55-62	mitogen-activated protein kinase 9	Homo sapiens	4-8	
9162025-2	1997	JUN/SAPK is activated by DNA damage and phosphorylates serines 63 and 73 in the N-terminal domain of c-Jun, which is known to increase its transactivation properties.	Serine	55-62	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	101-106	
9162025-3	1997	We show that treatment of T98G glioblastoma cells with cisplatin but not the transplatin isomer activates JNK/SAPK about 10-fold.	Cisplatin	55-64	mitogen-activated protein kinase 8	Homo sapiens	106-109	
9162025-3	1997	We show that treatment of T98G glioblastoma cells with cisplatin but not the transplatin isomer activates JNK/SAPK about 10-fold.	Cisplatin	55-64	mitogen-activated protein kinase 9	Homo sapiens	110-114	
9162025-4	1997	T98G cells, which are highly resistent to cisplatin (IC50 = 140 +/- 13 microM), modified to express a nonphosphorylatable dominant negative c-Jun (termed dnJun) exhibit decreased viability following treatment with cisplatin, but not transplatin, in proportion (rPearson = 0.98) to the level of dnJun expressed leading to a 7-fold decreased IC50.	Cisplatin	214-223	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	140-145	
9162025-5	1997	Similar effects are observed in U87 cells, PC-3 cells, and MCF-7 cells, as well as in T98G cells modified to express TAM-67, a known inhibitor of c-Jun function.	tam-67	117-123	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	146-151	
9162025-8	1997	These observations indicate that the JNK/SAPK pathway is activated by cisplatin-induced DNA damage and that this response is required for DNA repair and viability following cisplatin treatment.	Cisplatin	70-79	mitogen-activated protein kinase 8	Homo sapiens	37-40	
9162025-8	1997	These observations indicate that the JNK/SAPK pathway is activated by cisplatin-induced DNA damage and that this response is required for DNA repair and viability following cisplatin treatment.	Cisplatin	70-79	mitogen-activated protein kinase 9	Homo sapiens	41-45	
9162025-8	1997	These observations indicate that the JNK/SAPK pathway is activated by cisplatin-induced DNA damage and that this response is required for DNA repair and viability following cisplatin treatment.	Cisplatin	173-182	mitogen-activated protein kinase 8	Homo sapiens	37-40	
9162025-8	1997	These observations indicate that the JNK/SAPK pathway is activated by cisplatin-induced DNA damage and that this response is required for DNA repair and viability following cisplatin treatment.	Cisplatin	173-182	mitogen-activated protein kinase 9	Homo sapiens	41-45