PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9090707-1	1997	PURPOSE: To study the signal transduction mechanisms of tamoxifen via the activation of MAPKs, JNK and ERK in order to understand its regulation of gene expression.	Tamoxifen	56-65	mitogen-activated protein kinase 8	Homo sapiens	95-98	
9090707-1	1997	PURPOSE: To study the signal transduction mechanisms of tamoxifen via the activation of MAPKs, JNK and ERK in order to understand its regulation of gene expression.	Tamoxifen	56-65	mitogen-activated protein kinase 1	Homo sapiens	103-106	
9090707-2	1997	METHODS: The effects of tamoxifen (TAM) on the activation of serine/threonine mitogen-activated protein kinase (MAPK, p42/ERK2) and the stress-activated protein kinases (p46 SAPK or c-Jun N-terminal kinase, JNK1) were evaluated using a human cervical epitheloid carcinoma HeLa cell line.	Tamoxifen	24-33	mitogen-activated protein kinase 1	Homo sapiens	112-116	
9090707-2	1997	METHODS: The effects of tamoxifen (TAM) on the activation of serine/threonine mitogen-activated protein kinase (MAPK, p42/ERK2) and the stress-activated protein kinases (p46 SAPK or c-Jun N-terminal kinase, JNK1) were evaluated using a human cervical epitheloid carcinoma HeLa cell line.	Tamoxifen	24-33	cyclin dependent kinase 20	Homo sapiens	118-121	
9090707-2	1997	METHODS: The effects of tamoxifen (TAM) on the activation of serine/threonine mitogen-activated protein kinase (MAPK, p42/ERK2) and the stress-activated protein kinases (p46 SAPK or c-Jun N-terminal kinase, JNK1) were evaluated using a human cervical epitheloid carcinoma HeLa cell line.	Tamoxifen	35-38	mitogen-activated protein kinase 1	Homo sapiens	112-116	
9090707-2	1997	METHODS: The effects of tamoxifen (TAM) on the activation of serine/threonine mitogen-activated protein kinase (MAPK, p42/ERK2) and the stress-activated protein kinases (p46 SAPK or c-Jun N-terminal kinase, JNK1) were evaluated using a human cervical epitheloid carcinoma HeLa cell line.	Tamoxifen	35-38	cyclin dependent kinase 20	Homo sapiens	118-121	
9090707-2	1997	METHODS: The effects of tamoxifen (TAM) on the activation of serine/threonine mitogen-activated protein kinase (MAPK, p42/ERK2) and the stress-activated protein kinases (p46 SAPK or c-Jun N-terminal kinase, JNK1) were evaluated using a human cervical epitheloid carcinoma HeLa cell line.	Tamoxifen	35-38	mitogen-activated protein kinase 1	Homo sapiens	122-126	
9090707-3	1997	RESULTS: TAM activated both JNK1 and ERK2 activities in a time- and dose-dependent manner in HeLa cells.	Tamoxifen	9-12	mitogen-activated protein kinase 8	Homo sapiens	28-32	
9090707-3	1997	RESULTS: TAM activated both JNK1 and ERK2 activities in a time- and dose-dependent manner in HeLa cells.	Tamoxifen	9-12	mitogen-activated protein kinase 1	Homo sapiens	37-41	
9090707-4	1997	The activation of JNK1 was enhanced when the cells were pretreated with prooxidant H2O2.	Hydrogen Peroxide	83-87	mitogen-activated protein kinase 8	Homo sapiens	18-22	
9090707-5	1997	CONCLUSIONS: These studies show that TAM activates the signal transduction kinases, JNK1 and ERK2, which may play important roles in the regulation of gene expression by TAM.	Tamoxifen	37-40	mitogen-activated protein kinase 8	Homo sapiens	84-88	
9090707-5	1997	CONCLUSIONS: These studies show that TAM activates the signal transduction kinases, JNK1 and ERK2, which may play important roles in the regulation of gene expression by TAM.	Tamoxifen	37-40	mitogen-activated protein kinase 1	Homo sapiens	93-97	
9090707-5	1997	CONCLUSIONS: These studies show that TAM activates the signal transduction kinases, JNK1 and ERK2, which may play important roles in the regulation of gene expression by TAM.	Tamoxifen	170-173	mitogen-activated protein kinase 8	Homo sapiens	84-88	
9090707-5	1997	CONCLUSIONS: These studies show that TAM activates the signal transduction kinases, JNK1 and ERK2, which may play important roles in the regulation of gene expression by TAM.	Tamoxifen	170-173	mitogen-activated protein kinase 1	Homo sapiens	93-97