PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9044846-0	1997	Increased gadd153 messenger RNA level is associated with apoptosis in human leukemic cells treated with etoposide.	Etoposide	104-113	DNA damage inducible transcript 3	Homo sapiens	10-17	
9044846-4	1997	We have investigated the relationships between gadd153 gene expression and apoptosis induction in four human leukemic cell lines with different sensitivities to apoptosis induced by etoposide (VP-16), a topoisomerase II inhibitor.	Etoposide	182-191	DNA damage inducible transcript 3	Homo sapiens	47-54	
9044846-4	1997	We have investigated the relationships between gadd153 gene expression and apoptosis induction in four human leukemic cell lines with different sensitivities to apoptosis induced by etoposide (VP-16), a topoisomerase II inhibitor.	Etoposide	182-191	host cell factor C1	Homo sapiens	193-198	
9044846-11	1997	Both gadd153 mRNA level increase and internucleosomal DNA fragmentation were inhibited by N-tosyl-L-phenylalanine chloromethylketone, a serine threonine protease inhibitor, N-acetyl-leucyl-leucyl-norleucinal, an inhibitor of calpain, N-acetylcysteine, an inhibitor of oxidative metabolism, and overexpression of Bcl-2.	Tosylphenylalanyl Chloromethyl Ketone	90-132	DNA damage inducible transcript 3	Homo sapiens	5-12	
9044846-11	1997	Both gadd153 mRNA level increase and internucleosomal DNA fragmentation were inhibited by N-tosyl-L-phenylalanine chloromethylketone, a serine threonine protease inhibitor, N-acetyl-leucyl-leucyl-norleucinal, an inhibitor of calpain, N-acetylcysteine, an inhibitor of oxidative metabolism, and overexpression of Bcl-2.	Tosylphenylalanyl Chloromethyl Ketone	90-132	BCL2 apoptosis regulator	Homo sapiens	312-317	
9044846-11	1997	Both gadd153 mRNA level increase and internucleosomal DNA fragmentation were inhibited by N-tosyl-L-phenylalanine chloromethylketone, a serine threonine protease inhibitor, N-acetyl-leucyl-leucyl-norleucinal, an inhibitor of calpain, N-acetylcysteine, an inhibitor of oxidative metabolism, and overexpression of Bcl-2.	Acetylcysteine	234-250	DNA damage inducible transcript 3	Homo sapiens	5-12	
9044846-13	1997	These results indicate that gadd153 gene expression increase occurs downstream of events sensitive to N-tosyl-L-phenylalanine chloromethylketone, calpain inhibitor I, and Bcl-2 and upstream of interleukin 1beta-converting enzyme-related proteases activation in leukemic cells in which treatment with VP-16 induces rapid apoptosis.	Tosylphenylalanyl Chloromethyl Ketone	102-144	DNA damage inducible transcript 3	Homo sapiens	28-35