PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9041054-0 1997 Regulation of interleukin-6 secretion from mononuclear blood cells by extracellular calcium. Calcium 84-91 interleukin 6 Homo sapiens 14-27 9041054-3 1997 We recently reported that the calcium concentration in plasma affects IL-6 secretion from mononuclear blood cells. Calcium 30-37 interleukin 6 Homo sapiens 70-74 9041054-4 1997 To investigate the underlying mechanism, we have studied the effect of calcium on IL-6 formation in mononuclear blood cells ex vivo and in vitro. Calcium 71-78 interleukin 6 Homo sapiens 82-86 9041054-8 1997 IL-6 secretion ex vivo from mononuclear blood cells drawn 4 h after calcium intake was increased 185% as compared with IL-6 secretion from cells drawn just before calcium intake. Calcium 68-75 interleukin 6 Homo sapiens 0-4 9041054-8 1997 IL-6 secretion ex vivo from mononuclear blood cells drawn 4 h after calcium intake was increased 185% as compared with IL-6 secretion from cells drawn just before calcium intake. Calcium 163-170 interleukin 6 Homo sapiens 0-4 9041054-10 1997 In vitro studies revealed that stimulation of isolated mononuclear blood cells with physiological concentrations of calcium dose-dependently increased IL-6 secretion with an estimated EC50 at 1.2 mM Ca2+. Calcium 116-123 interleukin 6 Homo sapiens 151-155 9041054-12 1997 These observations demonstrate that the plasma calcium concentration affects IL-6 secretion from mononuclear blood cells. Calcium 47-54 interleukin 6 Homo sapiens 77-81