PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
8968370-0	1996	Enhanced inhibition of microsomal cytochrome P450 3A2 in rat liver during diltiazem biotransformation.	Diltiazem	74-83	cytochrome P450, family 3, subfamily a, polypeptide 2	Rattus norvegicus	34-53	
8968370-4	1996	The principal finding to emerge was that the N-demethylated metabolite of DTZ was a more potent competitive inhibitor than DTZ of CYP3A2-dependent testosterone 6 beta-hydroxylation.	Nitrogen	45-46	cytochrome P450, family 3, subfamily a, polypeptide 2	Rattus norvegicus	130-136	
8968370-4	1996	The principal finding to emerge was that the N-demethylated metabolite of DTZ was a more potent competitive inhibitor than DTZ of CYP3A2-dependent testosterone 6 beta-hydroxylation.	Diltiazem	74-77	cytochrome P450, family 3, subfamily a, polypeptide 2	Rattus norvegicus	130-136	
8968370-4	1996	The principal finding to emerge was that the N-demethylated metabolite of DTZ was a more potent competitive inhibitor than DTZ of CYP3A2-dependent testosterone 6 beta-hydroxylation.	Diltiazem	123-126	cytochrome P450, family 3, subfamily a, polypeptide 2	Rattus norvegicus	130-136	
8968370-5	1996	This P450 appeared to be the preferred target for inhibition, because the observed K/K(m) ratio for inhibition of CYP3A2-dependent steroid hydroxylation was approximately 4- and 100-fold lower than those for CYP2C11 and CYP2A1-dependent pathways, respectively.	Steroids	131-138	cytochrome P450, family 3, subfamily a, polypeptide 2	Rattus norvegicus	114-120	
8968370-5	1996	This P450 appeared to be the preferred target for inhibition, because the observed K/K(m) ratio for inhibition of CYP3A2-dependent steroid hydroxylation was approximately 4- and 100-fold lower than those for CYP2C11 and CYP2A1-dependent pathways, respectively.	Steroids	131-138	cytochrome P450, subfamily 2, polypeptide 11	Rattus norvegicus	208-215	
8968370-5	1996	This P450 appeared to be the preferred target for inhibition, because the observed K/K(m) ratio for inhibition of CYP3A2-dependent steroid hydroxylation was approximately 4- and 100-fold lower than those for CYP2C11 and CYP2A1-dependent pathways, respectively.	Steroids	131-138	cytochrome P450, family 2, subfamily a, polypeptide 1	Rattus norvegicus	220-226	
8968370-9	1996	Considered together, the findings of the present study establish that N-desmethyl-DTZ is a preferential inhibitor of CYP3A2 in rat hepatic microsomes, with greater potency than the parent drug.	N-monodemethyldiltiazem	70-85	cytochrome P450, family 3, subfamily a, polypeptide 2	Rattus norvegicus	117-123