PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
8865369-0	1996	Trimethadione N-demethylation by rat liver CYP2E1 in vitro.	Trimethadione	0-13	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	43-49	
8865369-1	1996	Trimethadione (TMO) is a model drug utilized for estimation of hepatic metabolism in clinical studies, and it was reported that TMO N-demethylase activity was inhibited by CYP2E1 inhibitors and substrates in rat in vivo.	Trimethadione	0-13	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	172-178	
8865369-1	1996	Trimethadione (TMO) is a model drug utilized for estimation of hepatic metabolism in clinical studies, and it was reported that TMO N-demethylase activity was inhibited by CYP2E1 inhibitors and substrates in rat in vivo.	Trimethadione	15-18	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	172-178	
8865369-2	1996	This study was performed to investigate the involvement of the CYP2E1 subfamily on TMO N-demethylation in vitro and to clarify these inhibitory mechanisms.	tmo n	83-88	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	63-69	
8865369-12	1996	These results indicate that the CYP2E1 subfamily is the major enzyme involved in TMO N-demethylation in rat in vitro although the CYP3A2 is also involved in this transformation.	Nitrogen	85-86	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	32-38	
8865369-12	1996	These results indicate that the CYP2E1 subfamily is the major enzyme involved in TMO N-demethylation in rat in vitro although the CYP3A2 is also involved in this transformation.	Nitrogen	85-86	cytochrome P450, family 3, subfamily a, polypeptide 2	Rattus norvegicus	130-136