PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
8760145-2	1996	In this study, we tested the hypothesis that ROS are directly involved in the induction of the mitochondrial antioxidant manganese superoxide dismutase (MnSOD) and mediate the induction of MnSOD by tumor necrosis factor-alpha (TNF-alpha).	Reactive Oxygen Species	45-48	superoxide dismutase 2	Homo sapiens	153-158	
8760145-2	1996	In this study, we tested the hypothesis that ROS are directly involved in the induction of the mitochondrial antioxidant manganese superoxide dismutase (MnSOD) and mediate the induction of MnSOD by tumor necrosis factor-alpha (TNF-alpha).	Reactive Oxygen Species	45-48	superoxide dismutase 2	Homo sapiens	189-194	
8760145-3	1996	Pretreatment of human pulmonary adenocarcinoma cells H441 with the antioxidants N-acetyl-L-cysteine (NAC) and nordihydroguaiaretic acid (NDGA) blocked MnSOD induction by TNF-alpha, implicating ROS as a signaling agent in this pathway.	Reactive Oxygen Species	193-196	superoxide dismutase 2	Homo sapiens	151-156	
8760145-4	1996	Treatment of H441 cells with the exogenous oxidants hydrogen peroxide (H2O2) and diamide increased MnSOD mRNA, supporting the hypothesis that ROS directly affect expression of MnSOD.	Reactive Oxygen Species	142-145	superoxide dismutase 2	Homo sapiens	99-104	
8760145-4	1996	Treatment of H441 cells with the exogenous oxidants hydrogen peroxide (H2O2) and diamide increased MnSOD mRNA, supporting the hypothesis that ROS directly affect expression of MnSOD.	Reactive Oxygen Species	142-145	superoxide dismutase 2	Homo sapiens	176-181	
8760145-10	1996	We conclude that ROS directly alter MnSOD expression and are involved in the induction of MnSOD by TNF-alpha.	Reactive Oxygen Species	17-20	superoxide dismutase 2	Homo sapiens	36-41	
8760145-10	1996	We conclude that ROS directly alter MnSOD expression and are involved in the induction of MnSOD by TNF-alpha.	Reactive Oxygen Species	17-20	superoxide dismutase 2	Homo sapiens	90-95