PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
8626428-0	1996	SOS phosphorylation and disassociation of the Grb2-SOS complex by the ERK and JNK signaling pathways.	sulfur monoxide	0-3	growth factor receptor bound protein 2	Homo sapiens	46-50	
8626428-0	1996	SOS phosphorylation and disassociation of the Grb2-SOS complex by the ERK and JNK signaling pathways.	sulfur monoxide	0-3	mitogen-activated protein kinase 1	Homo sapiens	70-73	
8626428-0	1996	SOS phosphorylation and disassociation of the Grb2-SOS complex by the ERK and JNK signaling pathways.	sulfur monoxide	0-3	mitogen-activated protein kinase 8	Homo sapiens	78-81	
8626428-0	1996	SOS phosphorylation and disassociation of the Grb2-SOS complex by the ERK and JNK signaling pathways.	sulfur monoxide	51-54	growth factor receptor bound protein 2	Homo sapiens	46-50	
8626428-0	1996	SOS phosphorylation and disassociation of the Grb2-SOS complex by the ERK and JNK signaling pathways.	sulfur monoxide	51-54	mitogen-activated protein kinase 1	Homo sapiens	70-73	
8626428-0	1996	SOS phosphorylation and disassociation of the Grb2-SOS complex by the ERK and JNK signaling pathways.	sulfur monoxide	51-54	mitogen-activated protein kinase 8	Homo sapiens	78-81	
8626428-2	1996	SOS also lies in an insulin-stimulated feedback pathway in which the serine/threonine phosphorylation of SOS results in disassociation of the Grb2-SOS complex thereby limiting the extent of Ras activation.	Serine	69-75	insulin	Homo sapiens	20-27	
8626428-2	1996	SOS also lies in an insulin-stimulated feedback pathway in which the serine/threonine phosphorylation of SOS results in disassociation of the Grb2-SOS complex thereby limiting the extent of Ras activation.	Serine	69-75	growth factor receptor bound protein 2	Homo sapiens	142-146	
8626428-2	1996	SOS also lies in an insulin-stimulated feedback pathway in which the serine/threonine phosphorylation of SOS results in disassociation of the Grb2-SOS complex thereby limiting the extent of Ras activation.	Threonine	76-85	insulin	Homo sapiens	20-27	
8626428-2	1996	SOS also lies in an insulin-stimulated feedback pathway in which the serine/threonine phosphorylation of SOS results in disassociation of the Grb2-SOS complex thereby limiting the extent of Ras activation.	Threonine	76-85	growth factor receptor bound protein 2	Homo sapiens	142-146	
8626428-2	1996	SOS also lies in an insulin-stimulated feedback pathway in which the serine/threonine phosphorylation of SOS results in disassociation of the Grb2-SOS complex thereby limiting the extent of Ras activation.	sulfur monoxide	0-3	insulin	Homo sapiens	20-27	
8626428-2	1996	SOS also lies in an insulin-stimulated feedback pathway in which the serine/threonine phosphorylation of SOS results in disassociation of the Grb2-SOS complex thereby limiting the extent of Ras activation.	sulfur monoxide	0-3	growth factor receptor bound protein 2	Homo sapiens	142-146	
8626428-3	1996	To examine the relative role of the mitogen-activated protein kinases in the feedback phosphorylation of SOS we determined the signaling specificity of insulin, osmotic shock, and anisomycin to activate the ERK (extracellular-signal regulated kinase) and JNK (c-Jun kinase) pathways.	Anisomycin	180-190	mitogen-activated protein kinase 1	Homo sapiens	207-210	
8626428-3	1996	To examine the relative role of the mitogen-activated protein kinases in the feedback phosphorylation of SOS we determined the signaling specificity of insulin, osmotic shock, and anisomycin to activate the ERK (extracellular-signal regulated kinase) and JNK (c-Jun kinase) pathways.	Anisomycin	180-190	mitogen-activated protein kinase 1	Homo sapiens	212-249	
8626428-3	1996	To examine the relative role of the mitogen-activated protein kinases in the feedback phosphorylation of SOS we determined the signaling specificity of insulin, osmotic shock, and anisomycin to activate the ERK (extracellular-signal regulated kinase) and JNK (c-Jun kinase) pathways.	Anisomycin	180-190	mitogen-activated protein kinase 8	Homo sapiens	255-258	
8626428-3	1996	To examine the relative role of the mitogen-activated protein kinases in the feedback phosphorylation of SOS we determined the signaling specificity of insulin, osmotic shock, and anisomycin to activate the ERK (extracellular-signal regulated kinase) and JNK (c-Jun kinase) pathways.	Anisomycin	180-190	mitogen-activated protein kinase 8	Homo sapiens	260-272	
8626428-4	1996	In Chinese hamster ovary cells expressing the human insulin receptor and murine 3T3L1 adipocytes, insulin specifically activated ERK with no significant effect on JNK, whereas anisomycin specifically activated JNK but was unable to activate ERK.	Anisomycin	176-186	insulin	Homo sapiens	52-59	
8626428-4	1996	In Chinese hamster ovary cells expressing the human insulin receptor and murine 3T3L1 adipocytes, insulin specifically activated ERK with no significant effect on JNK, whereas anisomycin specifically activated JNK but was unable to activate ERK.	Anisomycin	176-186	mitogen-activated protein kinase 8	Mus musculus	210-213	
8626428-6	1996	Insulin and osmotic shock, but not anisomycin, resulted in SOS phosphorylation and disassociation of the Grb2-SOS complex, demonstrating that the JNK pathway was not involved in the insulin-stimulated feedback uncoupling of the Grb2- SOS complex.	sulfur monoxide	59-62	insulin	Homo sapiens	0-7	
8626428-6	1996	Insulin and osmotic shock, but not anisomycin, resulted in SOS phosphorylation and disassociation of the Grb2-SOS complex, demonstrating that the JNK pathway was not involved in the insulin-stimulated feedback uncoupling of the Grb2- SOS complex.	sulfur monoxide	110-113	insulin	Homo sapiens	0-7	
8626428-6	1996	Insulin and osmotic shock, but not anisomycin, resulted in SOS phosphorylation and disassociation of the Grb2-SOS complex, demonstrating that the JNK pathway was not involved in the insulin-stimulated feedback uncoupling of the Grb2- SOS complex.	sulfur monoxide	110-113	growth factor receptor bound protein 2	Homo sapiens	105-109	
8626428-6	1996	Insulin and osmotic shock, but not anisomycin, resulted in SOS phosphorylation and disassociation of the Grb2-SOS complex, demonstrating that the JNK pathway was not involved in the insulin-stimulated feedback uncoupling of the Grb2- SOS complex.	sulfur monoxide	110-113	insulin	Homo sapiens	0-7	
8626428-6	1996	Insulin and osmotic shock, but not anisomycin, resulted in SOS phosphorylation and disassociation of the Grb2-SOS complex, demonstrating that the JNK pathway was not involved in the insulin-stimulated feedback uncoupling of the Grb2- SOS complex.	sulfur monoxide	110-113	growth factor receptor bound protein 2	Homo sapiens	105-109	
8626428-7	1996	Both the insulin and osmotic shock-induced activation of ERK was prevented by treatment of cells with the specific MEK inhibitor (PD98059).	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	130-137	insulin	Homo sapiens	9-16	
8626428-7	1996	Both the insulin and osmotic shock-induced activation of ERK was prevented by treatment of cells with the specific MEK inhibitor (PD98059).	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	130-137	mitogen-activated protein kinase 1	Homo sapiens	57-60	
8626428-7	1996	Both the insulin and osmotic shock-induced activation of ERK was prevented by treatment of cells with the specific MEK inhibitor (PD98059).	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	130-137	mitogen-activated protein kinase kinase 7	Homo sapiens	115-118