PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8572176-8 1995 Treatment with alpha-difluoromethylornithine (DFMO), a specific inhibitor of ODC, not only completely depleted intracellular polyamines but also significantly prevented the increased expression of c-myc in cells exposed to gastrin. Eflornithine 15-44 MYC proto-oncogene, bHLH transcription factor Rattus norvegicus 197-202 8572176-8 1995 Treatment with alpha-difluoromethylornithine (DFMO), a specific inhibitor of ODC, not only completely depleted intracellular polyamines but also significantly prevented the increased expression of c-myc in cells exposed to gastrin. Eflornithine 46-50 MYC proto-oncogene, bHLH transcription factor Rattus norvegicus 197-202 8572176-9 1995 These results show that 1) gastrin stimulates both polyamine biosynthesis and the expression of the c-myc protooncogene, and 2) depletion of intracellular polyamines by DFMO significantly prevented the increased expression of c-myc by gastrin. Eflornithine 169-173 MYC proto-oncogene, bHLH transcription factor Rattus norvegicus 100-105 8572176-9 1995 These results show that 1) gastrin stimulates both polyamine biosynthesis and the expression of the c-myc protooncogene, and 2) depletion of intracellular polyamines by DFMO significantly prevented the increased expression of c-myc by gastrin. Eflornithine 169-173 MYC proto-oncogene, bHLH transcription factor Rattus norvegicus 226-231