PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8554977-9 1996 We conclude that (1) taxol and cDDP activate GADD153 promoter activity through different mechanisms; (2) the signal transduction pathway mediating induction by cDDP involves a tyrosine kinase inhibitable by tyrphostin B46; and (3) that inhibition of this signal transduction pathway by tyrphostin synergistically enhances cDDP toxicity. Tyrphostins 207-217 DNA damage inducible transcript 3 Homo sapiens 45-52