PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
8554977-0	1996	Cisplatin and taxol activate different signal pathways regulating cellular injury-induced expression of GADD153.	Cisplatin	0-9	DNA damage inducible transcript 3	Homo sapiens	104-111	
8554977-0	1996	Cisplatin and taxol activate different signal pathways regulating cellular injury-induced expression of GADD153.	Paclitaxel	14-19	DNA damage inducible transcript 3	Homo sapiens	104-111	
8554977-4	1996	Activation of the GADD153 promoter coupled to the luciferase gene and transfected into human ovarian carcinoma 2008 cells correlated well with the increase in endogenous GADD153 mRNA after treatment with taxol but not after treatment with cDDP.	Paclitaxel	204-209	DNA damage inducible transcript 3	Homo sapiens	18-25	
8554977-4	1996	Activation of the GADD153 promoter coupled to the luciferase gene and transfected into human ovarian carcinoma 2008 cells correlated well with the increase in endogenous GADD153 mRNA after treatment with taxol but not after treatment with cDDP.	Paclitaxel	204-209	DNA damage inducible transcript 3	Homo sapiens	170-177	
8554977-5	1996	Following treatment with cDDP, the increase in endogenous GADD153 mRNA was 10-fold greater than the increase in GADD153 promoter activity.	Cisplatin	25-29	DNA damage inducible transcript 3	Homo sapiens	58-65	
8554977-5	1996	Following treatment with cDDP, the increase in endogenous GADD153 mRNA was 10-fold greater than the increase in GADD153 promoter activity.	Cisplatin	25-29	DNA damage inducible transcript 3	Homo sapiens	112-119	
8554977-6	1996	Likewise, at equitoxic levels of exposure (IC80), cDDP produced a 5-fold greater increase in endogenous GADD153 mRNA than taxol.	Cisplatin	50-54	DNA damage inducible transcript 3	Homo sapiens	104-111	
8554977-7	1996	The tyrosine kinase inhibitor tyrophostin B46 had no significant effect on the ability of taxol to activate the GADD153 promoter, but inhibited activation of the GADD153 promoter by cDDP in a concentration-dependent manner.	tyrophostin b46	30-45	DNA damage inducible transcript 3	Homo sapiens	162-169	
8554977-7	1996	The tyrosine kinase inhibitor tyrophostin B46 had no significant effect on the ability of taxol to activate the GADD153 promoter, but inhibited activation of the GADD153 promoter by cDDP in a concentration-dependent manner.	Cisplatin	182-186	DNA damage inducible transcript 3	Homo sapiens	162-169	
8554977-9	1996	We conclude that (1) taxol and cDDP activate GADD153 promoter activity through different mechanisms; (2) the signal transduction pathway mediating induction by cDDP involves a tyrosine kinase inhibitable by tyrphostin B46; and (3) that inhibition of this signal transduction pathway by tyrphostin synergistically enhances cDDP toxicity.	Paclitaxel	21-26	DNA damage inducible transcript 3	Homo sapiens	45-52	
8554977-9	1996	We conclude that (1) taxol and cDDP activate GADD153 promoter activity through different mechanisms; (2) the signal transduction pathway mediating induction by cDDP involves a tyrosine kinase inhibitable by tyrphostin B46; and (3) that inhibition of this signal transduction pathway by tyrphostin synergistically enhances cDDP toxicity.	Cisplatin	31-35	DNA damage inducible transcript 3	Homo sapiens	45-52	
8554977-9	1996	We conclude that (1) taxol and cDDP activate GADD153 promoter activity through different mechanisms; (2) the signal transduction pathway mediating induction by cDDP involves a tyrosine kinase inhibitable by tyrphostin B46; and (3) that inhibition of this signal transduction pathway by tyrphostin synergistically enhances cDDP toxicity.	Cisplatin	160-164	DNA damage inducible transcript 3	Homo sapiens	45-52	
8554977-9	1996	We conclude that (1) taxol and cDDP activate GADD153 promoter activity through different mechanisms; (2) the signal transduction pathway mediating induction by cDDP involves a tyrosine kinase inhibitable by tyrphostin B46; and (3) that inhibition of this signal transduction pathway by tyrphostin synergistically enhances cDDP toxicity.	alpha-cyano-(3,4-dihydroxy)-N-(3-phenylpropyl)cinnamide	207-221	DNA damage inducible transcript 3	Homo sapiens	45-52	
8554977-9	1996	We conclude that (1) taxol and cDDP activate GADD153 promoter activity through different mechanisms; (2) the signal transduction pathway mediating induction by cDDP involves a tyrosine kinase inhibitable by tyrphostin B46; and (3) that inhibition of this signal transduction pathway by tyrphostin synergistically enhances cDDP toxicity.	Tyrphostins	207-217	DNA damage inducible transcript 3	Homo sapiens	45-52	
8554977-9	1996	We conclude that (1) taxol and cDDP activate GADD153 promoter activity through different mechanisms; (2) the signal transduction pathway mediating induction by cDDP involves a tyrosine kinase inhibitable by tyrphostin B46; and (3) that inhibition of this signal transduction pathway by tyrphostin synergistically enhances cDDP toxicity.	Cisplatin	160-164	DNA damage inducible transcript 3	Homo sapiens	45-52