PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
8490103-3	1993	In the present study, the role of protein kinase C (PKC) in the production of TNF alpha was investigated in human peripheral blood monocytes stimulated with either LPS or zymosan.	Zymosan	171-178	proline rich transmembrane protein 2	Homo sapiens	34-50	
8490103-3	1993	In the present study, the role of protein kinase C (PKC) in the production of TNF alpha was investigated in human peripheral blood monocytes stimulated with either LPS or zymosan.	Zymosan	171-178	proline rich transmembrane protein 2	Homo sapiens	52-55	
8490103-5	1993	The results indicate that inhibition of PKC diminished LPS- or zymosan- induced TNF alpha production in a concentration-dependent manner.	Zymosan	63-70	proline rich transmembrane protein 2	Homo sapiens	40-43	
8490103-8	1993	LPS and zymosan also induced an increase in membrane associated PKC activity in human monocytes, which could be inhibited by pretreatment of the cells with calphostin C. Finally, western blot analysis with PKC isoform-specific antibodies demonstrates that the alpha and xi are the predominent isoforms expressed in human monocytes.	Zymosan	8-15	proline rich transmembrane protein 2	Homo sapiens	64-67	
8490103-8	1993	LPS and zymosan also induced an increase in membrane associated PKC activity in human monocytes, which could be inhibited by pretreatment of the cells with calphostin C. Finally, western blot analysis with PKC isoform-specific antibodies demonstrates that the alpha and xi are the predominent isoforms expressed in human monocytes.	Zymosan	8-15	proline rich transmembrane protein 2	Homo sapiens	206-209	
8490103-9	1993	These data strongly suggest that an initial step in TNF alpha production by human monocytes challenged with physiological stimulants, such as LPS and zymosan, involves a PKC-dependent mechanism.	Zymosan	150-157	proline rich transmembrane protein 2	Homo sapiens	170-173