PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8395533-0 1993 Interleukin-3 inhibits cycloheximide induction of C-jun mRNA in human monocytes: possible role for a serine/threonine phosphatase. Cycloheximide 23-36 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 50-55 8395533-1 1993 Cycloheximide is a strong inducer of the c-jun protooncogene mRNA at concentrations (< or = 50 ng/ml) that do not inhibit protein synthesis in human monocytes. Cycloheximide 0-13 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 41-46 8395533-3 1993 The pluripotent colony stimulating factor interleukin-3 (IL-3) (10 ng/ml) is also a modest inducer of the c-jun gene in these cells; however, in combination with cycloheximide, IL-3 dramatically reduces the c-jun induction below levels induced by cycloheximide alone. Cycloheximide 247-260 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 106-111 8395533-5 1993 Preincubation of monocytes with 12.5 nM okadaic acid (a potent inhibitor of protein phosphatases 1 and 2A) and cycloheximide prior to addition of IL-3 restored the level of c-jun induction to that mediated by cycloheximide alone. Cycloheximide 111-124 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 173-178 8395533-5 1993 Preincubation of monocytes with 12.5 nM okadaic acid (a potent inhibitor of protein phosphatases 1 and 2A) and cycloheximide prior to addition of IL-3 restored the level of c-jun induction to that mediated by cycloheximide alone. Cycloheximide 209-222 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 173-178 8395533-7 1993 These observations suggest that activation of protein serine/threonine phosphatase(s) underlies the ability of IL-3 to inhibit cycloheximide induction of c-jun in monocytes. Cycloheximide 127-140 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 154-159