PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
8311930-4	1993	RESULTS: HMC were found to specifically bind [125I]IL-1 with an apparent Kd of 2 x 10(-10) M. Incubation of HMC with IL-1 or TNF caused a time-dependent and dose-dependent accumulation of cAMP, as well as a significant potentiation of forskolin-promoted cAMP production.	Cyclic AMP	188-192	interleukin 1 alpha	Homo sapiens	117-121	
8311930-4	1993	RESULTS: HMC were found to specifically bind [125I]IL-1 with an apparent Kd of 2 x 10(-10) M. Incubation of HMC with IL-1 or TNF caused a time-dependent and dose-dependent accumulation of cAMP, as well as a significant potentiation of forskolin-promoted cAMP production.	Cyclic AMP	254-258	interleukin 1 alpha	Homo sapiens	117-121	
8311930-7	1993	CONCLUSIONS: It is suggested that IL-1 and TNF may activate one or more isoforms of the catalytic component of adenylyl cyclase, raising intracellular cAMP.	Cyclic AMP	151-155	interleukin 1 alpha	Homo sapiens	34-38