PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
8205621-1	1994	T lymphocyte activation and interleukin-2 (IL-2) production require at least two signals, generated by phorbol ester (TPA) and Ca2+ ionophore or costimulation of the T cell receptor (TCR) and the CD28 auxiliary receptor.	Phorbol Esters	103-116	interleukin 2	Homo sapiens	28-41	
8205621-1	1994	T lymphocyte activation and interleukin-2 (IL-2) production require at least two signals, generated by phorbol ester (TPA) and Ca2+ ionophore or costimulation of the T cell receptor (TCR) and the CD28 auxiliary receptor.	Phorbol Esters	103-116	interleukin 2	Homo sapiens	43-47	
8205621-1	1994	T lymphocyte activation and interleukin-2 (IL-2) production require at least two signals, generated by phorbol ester (TPA) and Ca2+ ionophore or costimulation of the T cell receptor (TCR) and the CD28 auxiliary receptor.	Tetradecanoylphorbol Acetate	118-121	interleukin 2	Homo sapiens	28-41	
8205621-1	1994	T lymphocyte activation and interleukin-2 (IL-2) production require at least two signals, generated by phorbol ester (TPA) and Ca2+ ionophore or costimulation of the T cell receptor (TCR) and the CD28 auxiliary receptor.	Tetradecanoylphorbol Acetate	118-121	interleukin 2	Homo sapiens	43-47	
8205621-1	1994	T lymphocyte activation and interleukin-2 (IL-2) production require at least two signals, generated by phorbol ester (TPA) and Ca2+ ionophore or costimulation of the T cell receptor (TCR) and the CD28 auxiliary receptor.	Tetradecanoylphorbol Acetate	118-121	CD28 molecule	Homo sapiens	196-200	
8205621-3	1994	Full activation of the MAP kinases that phosphorylate the Jun activation domain, JNK1 and JNK2, required costimulation of T cells with either TPA and Ca2+ ionophore or antibodies to TCR and CD28.	Tetradecanoylphorbol Acetate	142-145	mitogen-activated protein kinase 8	Homo sapiens	81-85	
8205621-3	1994	Full activation of the MAP kinases that phosphorylate the Jun activation domain, JNK1 and JNK2, required costimulation of T cells with either TPA and Ca2+ ionophore or antibodies to TCR and CD28.	Tetradecanoylphorbol Acetate	142-145	mitogen-activated protein kinase 9	Homo sapiens	90-94	
8205621-5	1994	Similar to its effect on IL-2 induction, cyclosporin A (CsA) inhibited the synergistic activation of JNK, and a competitive inhibitor of Jun phosphorylation by JNK inhibited IL-2 promoter activation.	Cyclosporine	56-59	mitogen-activated protein kinase 8	Homo sapiens	101-104	
8205621-6	1994	By contrast, the MAP kinases ERK1 and ERK2 were fully activated by TPA or TCR stimulation and were not affected by Ca2+, CD28, or CsA.	Tetradecanoylphorbol Acetate	67-70	mitogen-activated protein kinase 3	Homo sapiens	29-33	
8205621-6	1994	By contrast, the MAP kinases ERK1 and ERK2 were fully activated by TPA or TCR stimulation and were not affected by Ca2+, CD28, or CsA.	Tetradecanoylphorbol Acetate	67-70	mitogen-activated protein kinase 1	Homo sapiens	38-42