PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
8187833-0	1994	Phorbol ester TPA rapidly prevents activation of p34cdc2 histone H1 kinase and concomitantly the transition from G2 phase to mitosis in synchronized HeLa cells.	Tetradecanoylphorbol Acetate	14-17	cyclin dependent kinase 1	Homo sapiens	49-56	
8187833-4	1994	Treatment of HeLa cells (synchronized around the G2-M transition) with TPA (10(-7) M) has now been shown to induce an overall decrease of the histone H1 kinase activity associated with anti-p34cdc2 immunoprecipitates after about 20 to 30 min.	Tetradecanoylphorbol Acetate	71-74	cyclin dependent kinase 1	Homo sapiens	190-197	
8187833-8	1994	However, p34cdc2 from cultures treated with TPA was more intensely stained by anti-phosphotyrosine antibodies than that of control cells, indicating that TPA treatment probably prevented the tyrosine dephosphorylation required for expression of the histone H1 kinase activity of the complex.	Tetradecanoylphorbol Acetate	44-47	cyclin dependent kinase 1	Homo sapiens	9-16	
8187833-8	1994	However, p34cdc2 from cultures treated with TPA was more intensely stained by anti-phosphotyrosine antibodies than that of control cells, indicating that TPA treatment probably prevented the tyrosine dephosphorylation required for expression of the histone H1 kinase activity of the complex.	Tetradecanoylphorbol Acetate	154-157	cyclin dependent kinase 1	Homo sapiens	9-16	
8187833-9	1994	The results indicate that TPA treatment of HeLa cultures rapidly stops the G2-M transition because it very rapidly prevents the p34cdc2/Cyclin B complex in G2 cells from developing histone H1 kinase activity.	Tetradecanoylphorbol Acetate	26-29	cyclin dependent kinase 1	Homo sapiens	128-135