PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8183246-0 1994 Kinetics of inhibition by tyrphostins of the tyrosine kinase activity of the epidermal growth factor receptor and analysis by a new computer program. Tyrphostins 26-37 epidermal growth factor receptor Homo sapiens 77-109 8183246-1 1994 The kinetics of inhibition of the epidermal growth factor (EGF) receptor (EGFR) tyrosine kinase (TK) activity by erbstatin, tyrphostins, and lavendustin derivatives were studied in a system that employs poly(Glu6Ala3Tyr) (GAT) and ATP as substrates, after preactivation with EGF. Tyrphostins 124-135 epidermal growth factor receptor Homo sapiens 34-72 8183246-7 1994 Various possible modes of binding at the EGFR-TK active center for the tyrphostins studied are proposed and the significance of the present findings, as well as the interpretations of computer analyses of kinetic data, is discussed. Tyrphostins 71-82 epidermal growth factor receptor Homo sapiens 41-45