PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7947390-0 1994 Retroviral vector-mediated overexpression of the RII beta subunit of the cAMP-dependent protein kinase induces differentiation in human leukemia cells and reverts the transformed phenotype of mouse fibroblasts. 8-chloro-cyclic adenosine monophosphate 73-77 protein kinase cAMP-dependent type II regulatory subunit beta Homo sapiens 49-57 7947390-1 1994 We have recently shown, using antisense strategy, that the RII beta regulatory subunit of cAMP-dependent protein kinase is essential for cAMP-induced growth inhibition and differentiation of HL-60 human leukemia cells. 8-chloro-cyclic adenosine monophosphate 90-94 protein kinase cAMP-dependent type II regulatory subunit beta Homo sapiens 59-67 7947390-1 1994 We have recently shown, using antisense strategy, that the RII beta regulatory subunit of cAMP-dependent protein kinase is essential for cAMP-induced growth inhibition and differentiation of HL-60 human leukemia cells. 8-chloro-cyclic adenosine monophosphate 137-141 protein kinase cAMP-dependent type II regulatory subunit beta Homo sapiens 59-67 7947390-8 1994 The MT-RII beta-infected cells exhibited an increased sensitivity toward treatment with cAMP analogues, such as 8-Cl-cAMP and N6-benzyl-cAMP, as compared with the parental noninfected cells. 8-chloro-cyclic adenosine monophosphate 88-92 protein kinase cAMP-dependent type II regulatory subunit beta Homo sapiens 7-15 7947390-8 1994 The MT-RII beta-infected cells exhibited an increased sensitivity toward treatment with cAMP analogues, such as 8-Cl-cAMP and N6-benzyl-cAMP, as compared with the parental noninfected cells. 8-chloro-cyclic adenosine monophosphate 112-121 protein kinase cAMP-dependent type II regulatory subunit beta Homo sapiens 7-15 7947390-10 1994 These results suggest that the RII beta cAMP receptor, by binding to its ligand, cAMP, acts as a tumor suppressor protein exerting growth inhibition, differentiation, and reverse transformation. 8-chloro-cyclic adenosine monophosphate 40-44 protein kinase cAMP-dependent type II regulatory subunit beta Homo sapiens 31-39