PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7728897-0 1995 Characterization of hepatic microsomal cytochrome P-450 from rats treated with methylsulphonyl metabolites of polychlorinated biphenyl congeners. diphenyl 126-134 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 39-55 7728897-4 1995 Major PB-inducible forms, CYP2B1, CYP2B2, CYP3A2 and CYP2C6 were induced with four PCBs (342 mumol/kg) and their 3-MeSO2 metabolites (0.5-10 mumol/kg), indicating that 3-MeSO2 metabolites were strong PB-type inducers of hepatic drug-metabolizing enzymes. Polychlorinated Biphenyls 83-87 cytochrome P450, family 2, subfamily b, polypeptide 1 Rattus norvegicus 26-32 7728897-4 1995 Major PB-inducible forms, CYP2B1, CYP2B2, CYP3A2 and CYP2C6 were induced with four PCBs (342 mumol/kg) and their 3-MeSO2 metabolites (0.5-10 mumol/kg), indicating that 3-MeSO2 metabolites were strong PB-type inducers of hepatic drug-metabolizing enzymes. Polychlorinated Biphenyls 83-87 cytochrome P450, family 2, subfamily b, polypeptide 2 Rattus norvegicus 34-40 7728897-4 1995 Major PB-inducible forms, CYP2B1, CYP2B2, CYP3A2 and CYP2C6 were induced with four PCBs (342 mumol/kg) and their 3-MeSO2 metabolites (0.5-10 mumol/kg), indicating that 3-MeSO2 metabolites were strong PB-type inducers of hepatic drug-metabolizing enzymes. Polychlorinated Biphenyls 83-87 cytochrome P450, family 3, subfamily a, polypeptide 2 Rattus norvegicus 42-48 7728897-4 1995 Major PB-inducible forms, CYP2B1, CYP2B2, CYP3A2 and CYP2C6 were induced with four PCBs (342 mumol/kg) and their 3-MeSO2 metabolites (0.5-10 mumol/kg), indicating that 3-MeSO2 metabolites were strong PB-type inducers of hepatic drug-metabolizing enzymes. Polychlorinated Biphenyls 83-87 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 Rattus norvegicus 53-59 7728897-4 1995 Major PB-inducible forms, CYP2B1, CYP2B2, CYP3A2 and CYP2C6 were induced with four PCBs (342 mumol/kg) and their 3-MeSO2 metabolites (0.5-10 mumol/kg), indicating that 3-MeSO2 metabolites were strong PB-type inducers of hepatic drug-metabolizing enzymes. 3-meso2 113-120 cytochrome P450, family 2, subfamily b, polypeptide 2 Rattus norvegicus 34-40 7728897-4 1995 Major PB-inducible forms, CYP2B1, CYP2B2, CYP3A2 and CYP2C6 were induced with four PCBs (342 mumol/kg) and their 3-MeSO2 metabolites (0.5-10 mumol/kg), indicating that 3-MeSO2 metabolites were strong PB-type inducers of hepatic drug-metabolizing enzymes. 3-meso2 113-120 cytochrome P450, family 3, subfamily a, polypeptide 2 Rattus norvegicus 42-48 7728897-6 1995 On the other hand, four PB-inducible forms of cytochrome P-450 were not induced with the 4-MeSO2 isomers. Phenobarbital 24-26 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 46-62 7728897-7 1995 The relation between liver concentrations of the corresponding 3-MeSO2 derivatives and induction of four PB-inducible forms of cytochrome P-450 after administration of four PCBs and their 3-MeSO2 derivatives further confirmed that the 3-MeSO2 metabolites played an important role in the induction which parent PCB congeners caused on the hepatic drug-metabolizing enzyme system. 3-meso2 63-70 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 127-143 7728897-7 1995 The relation between liver concentrations of the corresponding 3-MeSO2 derivatives and induction of four PB-inducible forms of cytochrome P-450 after administration of four PCBs and their 3-MeSO2 derivatives further confirmed that the 3-MeSO2 metabolites played an important role in the induction which parent PCB congeners caused on the hepatic drug-metabolizing enzyme system. 3-meso2 63-70 pyruvate carboxylase Rattus norvegicus 173-176 7728897-7 1995 The relation between liver concentrations of the corresponding 3-MeSO2 derivatives and induction of four PB-inducible forms of cytochrome P-450 after administration of four PCBs and their 3-MeSO2 derivatives further confirmed that the 3-MeSO2 metabolites played an important role in the induction which parent PCB congeners caused on the hepatic drug-metabolizing enzyme system. Phenobarbital 105-107 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 127-143 7728897-7 1995 The relation between liver concentrations of the corresponding 3-MeSO2 derivatives and induction of four PB-inducible forms of cytochrome P-450 after administration of four PCBs and their 3-MeSO2 derivatives further confirmed that the 3-MeSO2 metabolites played an important role in the induction which parent PCB congeners caused on the hepatic drug-metabolizing enzyme system. Phenobarbital 105-107 pyruvate carboxylase Rattus norvegicus 173-176 7728897-7 1995 The relation between liver concentrations of the corresponding 3-MeSO2 derivatives and induction of four PB-inducible forms of cytochrome P-450 after administration of four PCBs and their 3-MeSO2 derivatives further confirmed that the 3-MeSO2 metabolites played an important role in the induction which parent PCB congeners caused on the hepatic drug-metabolizing enzyme system. Polychlorinated Biphenyls 173-177 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 127-143 7728897-7 1995 The relation between liver concentrations of the corresponding 3-MeSO2 derivatives and induction of four PB-inducible forms of cytochrome P-450 after administration of four PCBs and their 3-MeSO2 derivatives further confirmed that the 3-MeSO2 metabolites played an important role in the induction which parent PCB congeners caused on the hepatic drug-metabolizing enzyme system. 3-meso2 188-195 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 127-143 7728897-7 1995 The relation between liver concentrations of the corresponding 3-MeSO2 derivatives and induction of four PB-inducible forms of cytochrome P-450 after administration of four PCBs and their 3-MeSO2 derivatives further confirmed that the 3-MeSO2 metabolites played an important role in the induction which parent PCB congeners caused on the hepatic drug-metabolizing enzyme system. 3-meso2 188-195 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 127-143