PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7521210-0 1994 Potentiation of progesterone receptor-mediated transcription by the immunosuppressant FK506. Tacrolimus 86-91 progesterone receptor Homo sapiens 16-37 7521210-1 1994 The nontransformed steroid receptors contain several non-steroid binding proteins, such as hsp90, hsp70, and p59. Steroids 19-26 heat shock protein 90 alpha family class A member 1 Homo sapiens 91-96 7521210-1 1994 The nontransformed steroid receptors contain several non-steroid binding proteins, such as hsp90, hsp70, and p59. Steroids 19-26 heat shock protein family A (Hsp70) member 4 Homo sapiens 98-103 7521210-1 1994 The nontransformed steroid receptors contain several non-steroid binding proteins, such as hsp90, hsp70, and p59. Steroids 19-26 HLA complex P5B Homo sapiens 109-112 7521210-7 1994 To gain insight into the mechanism of FK506"s regulation of PR action, we questioned whether calcineurin is involved, because it has been shown that FK506 is a specific inhibitor of calcineurin, a Ca(2+)- and calmodulin-regulated phosphatase, through the formation of an FKBP12-FK506-calcineurin-calmodulin complex. Tacrolimus 149-154 FKBP prolyl isomerase 1A pseudogene 1 Homo sapiens 271-277 7521210-7 1994 To gain insight into the mechanism of FK506"s regulation of PR action, we questioned whether calcineurin is involved, because it has been shown that FK506 is a specific inhibitor of calcineurin, a Ca(2+)- and calmodulin-regulated phosphatase, through the formation of an FKBP12-FK506-calcineurin-calmodulin complex. Tacrolimus 149-154 FKBP prolyl isomerase 1A pseudogene 1 Homo sapiens 271-277 7521210-8 1994 We found that 15-O-desmethyl-FK520, an FK506 analogue which is an excellent ligand of FKBP12, but a poor inhibitor of calcineurin, failed to induce the same effect as FK506. 15-O-desmethyl-FK 520 14-34 FKBP prolyl isomerase 1A pseudogene 1 Homo sapiens 86-92 7521210-10 1994 Furthermore, immunoblot analysis showed that both FK506 and calmidazolium potentiated the effect of progesterone in decreasing the mobility of hPR-B upon sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE). Tacrolimus 50-55 RB transcriptional corepressor 1 Homo sapiens 143-148 7521210-10 1994 Furthermore, immunoblot analysis showed that both FK506 and calmidazolium potentiated the effect of progesterone in decreasing the mobility of hPR-B upon sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE). calmidazolium 60-73 RB transcriptional corepressor 1 Homo sapiens 143-148 7521210-10 1994 Furthermore, immunoblot analysis showed that both FK506 and calmidazolium potentiated the effect of progesterone in decreasing the mobility of hPR-B upon sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE). Progesterone 100-112 RB transcriptional corepressor 1 Homo sapiens 143-148 7521210-10 1994 Furthermore, immunoblot analysis showed that both FK506 and calmidazolium potentiated the effect of progesterone in decreasing the mobility of hPR-B upon sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE). Sodium Dodecyl Sulfate 154-176 RB transcriptional corepressor 1 Homo sapiens 143-148 7521210-10 1994 Furthermore, immunoblot analysis showed that both FK506 and calmidazolium potentiated the effect of progesterone in decreasing the mobility of hPR-B upon sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE). polyacrylamide 177-191 RB transcriptional corepressor 1 Homo sapiens 143-148 7521210-10 1994 Furthermore, immunoblot analysis showed that both FK506 and calmidazolium potentiated the effect of progesterone in decreasing the mobility of hPR-B upon sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE). Sodium Dodecyl Sulfate 213-216 RB transcriptional corepressor 1 Homo sapiens 143-148 7521210-11 1994 This suggests that FK506 and calmidazolium may cooperate with progesterone in increasing the level of hPR-B phosphorylation. Tacrolimus 19-24 RB transcriptional corepressor 1 Homo sapiens 102-107 7521210-11 1994 This suggests that FK506 and calmidazolium may cooperate with progesterone in increasing the level of hPR-B phosphorylation. calmidazolium 29-42 RB transcriptional corepressor 1 Homo sapiens 102-107 7521210-11 1994 This suggests that FK506 and calmidazolium may cooperate with progesterone in increasing the level of hPR-B phosphorylation. Progesterone 62-74 RB transcriptional corepressor 1 Homo sapiens 102-107