PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
7514637-0	1994	Zymosan-induced IL-8 release from human neutrophils involves activation via the CD11b/CD18 receptor and endogenous platelet-activating factor as an autocrine modulator.	Zymosan	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	16-20	
7514637-0	1994	Zymosan-induced IL-8 release from human neutrophils involves activation via the CD11b/CD18 receptor and endogenous platelet-activating factor as an autocrine modulator.	Zymosan	0-7	integrin subunit alpha M	Homo sapiens	80-85	
7514637-0	1994	Zymosan-induced IL-8 release from human neutrophils involves activation via the CD11b/CD18 receptor and endogenous platelet-activating factor as an autocrine modulator.	Zymosan	0-7	integrin subunit beta 2	Homo sapiens	86-90	
7514637-0	1994	Zymosan-induced IL-8 release from human neutrophils involves activation via the CD11b/CD18 receptor and endogenous platelet-activating factor as an autocrine modulator.	Zymosan	0-7	PCNA clamp associated factor	Homo sapiens	115-141	
7514637-1	1994	We have investigated mechanisms that regulate the generation of IL-8 by human neutrophils on contact with zymosan particles in vitro.	Zymosan	106-113	C-X-C motif chemokine ligand 8	Homo sapiens	64-68	
7514637-2	1994	Zymosan stimulated IL-8 production, which increased with increasing particle numbers and was abolished by the protein synthesis inhibitor cycloheximide.	Zymosan	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	19-23	
7514637-2	1994	Zymosan stimulated IL-8 production, which increased with increasing particle numbers and was abolished by the protein synthesis inhibitor cycloheximide.	Cycloheximide	138-151	C-X-C motif chemokine ligand 8	Homo sapiens	19-23	
7514637-3	1994	IL-8 was detectable in culture supernatant at 8 h reaching a maximum at 24 h. In all further experiments IL-8 was measured at 24 h. mAbs to neutrophil CD18 (60.3 and 6.5E) caused a marked suppression of IL-8 generation, but only if added up to 2 h after zymosan stimulation.	Zymosan	254-261	C-X-C motif chemokine ligand 8	Homo sapiens	0-4	
7514637-3	1994	IL-8 was detectable in culture supernatant at 8 h reaching a maximum at 24 h. In all further experiments IL-8 was measured at 24 h. mAbs to neutrophil CD18 (60.3 and 6.5E) caused a marked suppression of IL-8 generation, but only if added up to 2 h after zymosan stimulation.	Zymosan	254-261	integrin subunit beta 2	Homo sapiens	151-155	
7514637-4	1994	An anti-CD11b mAb (KIM 225) substantially inhibited zymosan-induced IL-8 release.	Zymosan	52-59	integrin subunit alpha M	Homo sapiens	8-13	
7514637-4	1994	An anti-CD11b mAb (KIM 225) substantially inhibited zymosan-induced IL-8 release.	Zymosan	52-59	C-X-C motif chemokine ligand 8	Homo sapiens	68-72	
7514637-6	1994	Two selective platelet-activating factor (PAF) receptor antagonists, WEB 2086 and UK 74505, produced a profound suppression of IL-8 generation, when added within 30 min to 1 h of zymosan stimulation.	Zymosan	179-186	platelet activating factor receptor	Homo sapiens	14-55	
7514637-6	1994	Two selective platelet-activating factor (PAF) receptor antagonists, WEB 2086 and UK 74505, produced a profound suppression of IL-8 generation, when added within 30 min to 1 h of zymosan stimulation.	Zymosan	179-186	C-X-C motif chemokine ligand 8	Homo sapiens	127-131	
7514637-8	1994	FMLP, PAF, and a stable PAF agonist did not stimulate significant IL-8 production, however, a calcium ionophore (A23187) did induce IL-8 release and this was suppressed by UK 74505.	Calcium	94-101	C-X-C motif chemokine ligand 8	Homo sapiens	132-136	
7514637-8	1994	FMLP, PAF, and a stable PAF agonist did not stimulate significant IL-8 production, however, a calcium ionophore (A23187) did induce IL-8 release and this was suppressed by UK 74505.	Calcimycin	113-119	C-X-C motif chemokine ligand 8	Homo sapiens	132-136	
7514637-9	1994	We conclude that zymosan-induced IL-8 generation involves stimulation of the neutrophil via a CD11b/CD18 receptor resulting in beta 2-integrin mediated activation of signal transduction mechanisms that leads to cytokine synthesis.	Zymosan	17-24	C-X-C motif chemokine ligand 8	Homo sapiens	33-37	
7514637-9	1994	We conclude that zymosan-induced IL-8 generation involves stimulation of the neutrophil via a CD11b/CD18 receptor resulting in beta 2-integrin mediated activation of signal transduction mechanisms that leads to cytokine synthesis.	Zymosan	17-24	integrin subunit alpha M	Homo sapiens	94-99	
7514637-9	1994	We conclude that zymosan-induced IL-8 generation involves stimulation of the neutrophil via a CD11b/CD18 receptor resulting in beta 2-integrin mediated activation of signal transduction mechanisms that leads to cytokine synthesis.	Zymosan	17-24	integrin subunit beta 2	Homo sapiens	100-104