PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7490793-1 1995 This study aimed to assess the possibility of a direct effect of betel-nut alkaloids arecoline and arecaidine on cell proliferation and interleukin-6 (IL-6) production by cultured fibroblasts from human normal gingiva, buccal mucosa and oral submucous fibrosis (OSF) buccal mucosa in vitro. Arecoline 85-94 interleukin 6 Homo sapiens 136-149 7490793-9 1995 However, two of six individuals" normal buccal mucosa fibroblasts significantly released less IL-6, and some cases of OSF and healthy gingiva exhibited slightly higher levels of IL-6 when cells were exposed to arecoline or arecaidine in cultures. Arecoline 210-219 interleukin 6 Homo sapiens 178-182 7490793-10 1995 Such findings suggests that arecoline and arecaidine can enhance cell proliferation and affect fibroblasts to synthesize IL-6. Arecoline 28-37 interleukin 6 Homo sapiens 121-125