PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 6894611-4 1981 Concomitant with heme oxygenase induction by antimony, microsomal heme and cytochrome P-450 contents decreased, the cyto-chrome P-450-dependent mixed function oxidase system was impaired, and delta-ami-nolevulinate synthase (ALAS), the rate-limiting enzyme of heme synthesis, underwent the sequential changes-initial inhibition followed by rebound induction-usually associated with the administration of transition elements such as cobalt. Heme 17-21 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 75-91