PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35594380-7 2022 Gain- and loss-of-function studies of PDE4D in cardiomyocytes implicated that inhibition of insulin-induced PDE4D protected cardiac hypertrophy by preserving miR-1 expression in cardiomyocytes through promoting cAMP-CREB-Sirt1 signaling-induced SERCA2a expression. Cyclic AMP 211-215 cAMP responsive element binding protein 1 Mus musculus 216-220