PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
35090865-1	2022	The aim of this study was to investigate the contributions of multiple transport mechanisms to the intestinal absorption of metformin, focusing on OCT3, PMAT, THTR2, SERT and OCTN2.	Metformin	124-133	solute carrier family 19 member 3	Homo sapiens	159-164	
35090865-3	2022	Uptake studies with MDCKII cells expressing OCT3, PMAT, THTR2 or SERT confirmed that metformin is a substrate of these transporters.	Metformin	85-94	solute carrier family 19 member 3	Homo sapiens	56-61	
35090865-5	2022	7-Cyclopentyl inhibited OCT3- and THTR2-mediated uptake of metformin.	Metformin	59-68	solute carrier family 19 member 3	Homo sapiens	34-39	
35090865-6	2022	AG835, thiamine and paroxetine specifically inhibited PMAT-, THTR2- and SERT-mediated uptake of metformin, respectively.	Metformin	96-105	solute carrier family 19 member 3	Homo sapiens	61-66	
35090865-7	2022	Using these inhibitors, the relative contributions of OCT3, PMAT, THTR2, SERT, OCTN2 and others to the intestinal permeation of metformin across Caco-2 cells were estimated to be 9.77%, 9.68%, 22.2%, 1.52%, 0% and 0.66%, respectively.	Metformin	128-137	solute carrier family 19 member 3	Homo sapiens	66-71	
35090865-8	2022	Concentration-dependent analysis of metformin uptake by Caco-2 cells revealed nonlinear kinetics with the similar Km(app) value to the value for THTR2.	Metformin	36-45	solute carrier family 19 member 3	Homo sapiens	145-150	
35090865-10	2022	The present study indicated that THTR2 is the major determinant of the nonlinear absorption of metformin, although multiple transport mechanisms contribute to its intestinal absorption.	Metformin	95-104	solute carrier family 19 member 3	Homo sapiens	33-38