PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34934478-0 2021 The fatty acid site is coupled to functional motifs in the SARS-CoV-2 spike protein and modulates spike allosteric behaviour. Fatty Acids 4-14 surface glycoprotein Severe acute respiratory syndrome coronavirus 2 70-75 34934478-0 2021 The fatty acid site is coupled to functional motifs in the SARS-CoV-2 spike protein and modulates spike allosteric behaviour. Fatty Acids 4-14 surface glycoprotein Severe acute respiratory syndrome coronavirus 2 98-103 34934478-2 2021 Recently, a fatty acid binding site was identified in the spike (Toelzer et al. Fatty Acids 12-22 surface glycoprotein Severe acute respiratory syndrome coronavirus 2 58-63 34934478-5 2021 Here, dynamical-nonequilibrium molecular dynamics simulations reveal that this fatty acid site is coupled to functionally relevant regions of the spike, some of them far from the fatty acid binding pocket. Fatty Acids 79-89 surface glycoprotein Severe acute respiratory syndrome coronavirus 2 146-151 34934478-5 2021 Here, dynamical-nonequilibrium molecular dynamics simulations reveal that this fatty acid site is coupled to functionally relevant regions of the spike, some of them far from the fatty acid binding pocket. Fatty Acids 179-189 surface glycoprotein Severe acute respiratory syndrome coronavirus 2 146-151 34934478-6 2021 Removal of a ligand from the fatty acid binding site significantly affects the dynamics of distant, functionally important regions of the spike, including the receptor-binding motif, furin cleavage site and fusion-peptide-adjacent regions. Fatty Acids 29-39 surface glycoprotein Severe acute respiratory syndrome coronavirus 2 138-143