PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34874108-4 2022 TiO2 NPs induced neuronal apoptosis through upregulation of the expression of caspase-8 and -9 that was further confirmed by increasing caspases-3 and -8 proteins in the hippocampus, cerebral cortex, and cerebellum. titanium dioxide 0-4 caspase 8 Rattus norvegicus 78-94 34874108-4 2022 TiO2 NPs induced neuronal apoptosis through upregulation of the expression of caspase-8 and -9 that was further confirmed by increasing caspases-3 and -8 proteins in the hippocampus, cerebral cortex, and cerebellum. titanium dioxide 0-4 caspase 3 Rattus norvegicus 136-153 34874108-5 2022 The expression of the immediate-early gene BDNF was increased in response to TiO2 NPs, while that of Arc was reduced. titanium dioxide 77-81 brain-derived neurotrophic factor Rattus norvegicus 43-47 34874108-6 2022 Chitosan significantly attenuated the TiO2 NPs-induced neurotoxicity regarding AChE, serotonin, MDA, GSH, GPx, GST, IL-6, caspases-8, -9, and -3. Chitosan 0-8 acetylcholinesterase Rattus norvegicus 79-83 34874108-6 2022 Chitosan significantly attenuated the TiO2 NPs-induced neurotoxicity regarding AChE, serotonin, MDA, GSH, GPx, GST, IL-6, caspases-8, -9, and -3. Chitosan 0-8 interleukin 6 Rattus norvegicus 116-120 34874108-6 2022 Chitosan significantly attenuated the TiO2 NPs-induced neurotoxicity regarding AChE, serotonin, MDA, GSH, GPx, GST, IL-6, caspases-8, -9, and -3. Chitosan 0-8 caspase 8 Rattus norvegicus 122-144 34874108-6 2022 Chitosan significantly attenuated the TiO2 NPs-induced neurotoxicity regarding AChE, serotonin, MDA, GSH, GPx, GST, IL-6, caspases-8, -9, and -3. titanium dioxide 38-42 acetylcholinesterase Rattus norvegicus 79-83 34874108-6 2022 Chitosan significantly attenuated the TiO2 NPs-induced neurotoxicity regarding AChE, serotonin, MDA, GSH, GPx, GST, IL-6, caspases-8, -9, and -3. titanium dioxide 38-42 interleukin 6 Rattus norvegicus 116-120 34874108-7 2022 Chitosan inhibited the expression of Arc and alleviated the effect of TiO2 NPs on BDNF expression. Chitosan 0-8 nucleolar protein 3 Rattus norvegicus 37-40 34874108-7 2022 Chitosan inhibited the expression of Arc and alleviated the effect of TiO2 NPs on BDNF expression. Chitosan 0-8 brain-derived neurotrophic factor Rattus norvegicus 82-86 34874108-7 2022 Chitosan inhibited the expression of Arc and alleviated the effect of TiO2 NPs on BDNF expression. titanium dioxide 70-74 brain-derived neurotrophic factor Rattus norvegicus 82-86