PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34864562-0 2022 Protegrin-1 inhibits porcine ovarian granulosa cell apoptosis from H2O2-induced oxidative stress via the PERK/eIF2alpha/CHOP signaling pathway in vitro. Hydrogen Peroxide 67-71 eukaryotic translation initiation factor 2A Homo sapiens 110-119 34864562-8 2022 Using Western blot analysis, it was found that PG-1 decreased the phosphorylation of RNA-like endoplasmic reticulum kinase (PERK) and the alpha-subunit of eukaryotic initiation factor 2 (eIF2alpha) as well as the protein expression level of CCAAT enhancer-binding protein homologous protein (CHOP), all of which were increased by H2O2. Hydrogen Peroxide 330-334 eukaryotic translation initiation factor 2A Homo sapiens 187-196 34864562-9 2022 Moreover, inhibitors against PERK and phospho-eIF2alpha both suppressed the H2O2-induced granulosa cells apoptosis and enhanced the anti-apoptosis effect of PG-1. Hydrogen Peroxide 76-80 eukaryotic translation initiation factor 2A Homo sapiens 46-55