PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34771624-0	2021	Analysis of NIS Plasma Membrane Interactors Discloses Key Regulation by a SRC/RAC1/PAK1/PIP5K/EZRIN Pathway with Potential Implications for Radioiodine Re-Sensitization Therapy in Thyroid Cancer.	Iodine-131	140-151	solute carrier family 5 member 5	Homo sapiens	12-15	
34771624-1	2021	The functional expression of the sodium-iodide symporter (NIS) at the membrane of differentiated thyroid cancer (DTC) cells is the cornerstone for the use of radioiodine (RAI) therapy in these malignancies.	Iodine-131	158-169	solute carrier family 5 member 5	Homo sapiens	58-61	
34771624-1	2021	The functional expression of the sodium-iodide symporter (NIS) at the membrane of differentiated thyroid cancer (DTC) cells is the cornerstone for the use of radioiodine (RAI) therapy in these malignancies.	Iodine-131	171-174	solute carrier family 5 member 5	Homo sapiens	58-61	
34771624-4	2021	However, there are many RAI-refractory DTCs in which the NIS mRNA and protein levels are relatively abundant but only reduced levels of iodide uptake are detected, suggesting a posttranslational failure in the delivery of NIS to the plasma membrane (PM), or an impaired residency at the PM.	Iodine-131	24-27	solute carrier family 5 member 5	Homo sapiens	57-60	
34771624-10	2021	Besides providing novel insights into the regulation of NIS localization and function at the PM of TC cells, our results open new venues for therapeutic intervention in TC, namely the possibility of modulating abnormal SRC signaling in refractory TC from a proliferative/invasive effect to the re-sensitization of these tumors to RAI therapy by inducing NIS retention at the PM.	Iodine-131	330-333	solute carrier family 5 member 5	Homo sapiens	56-59	
34771624-10	2021	Besides providing novel insights into the regulation of NIS localization and function at the PM of TC cells, our results open new venues for therapeutic intervention in TC, namely the possibility of modulating abnormal SRC signaling in refractory TC from a proliferative/invasive effect to the re-sensitization of these tumors to RAI therapy by inducing NIS retention at the PM.	Iodine-131	330-333	solute carrier family 5 member 5	Homo sapiens	354-357